WO2007136614A3 - Assays and methods for the diagnosis and progression of alzheimer's disease using a multi-analyte marker panel - Google Patents
Assays and methods for the diagnosis and progression of alzheimer's disease using a multi-analyte marker panel Download PDFInfo
- Publication number
- WO2007136614A3 WO2007136614A3 PCT/US2007/011594 US2007011594W WO2007136614A3 WO 2007136614 A3 WO2007136614 A3 WO 2007136614A3 US 2007011594 W US2007011594 W US 2007011594W WO 2007136614 A3 WO2007136614 A3 WO 2007136614A3
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- WO
- WIPO (PCT)
- Prior art keywords
- disease
- alzheimer
- progression
- assays
- diagnosis
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Urology & Nephrology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Data Mining & Analysis (AREA)
- Databases & Information Systems (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Primary Health Care (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The present invention provides a novel and sensitive means of monitoring Alzheimer's disease. The method consists of the construction of statistically relevant multi-analyte panels, through the use of shrunken centroids (SC), simulated annealing algorithm (SAA) and genetic algorithm (GA) within the framework of linear discriminant analysis (LDA) or through the use of random forest (RF) analysis of individual biomarkers, to more accurately and objectively assess the status of an individual for the purposes of disease classification and predicting cognitive endpoints such as MMSE, CAMCOG, or Learning Memory, a subscore of CAMCOG.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80196206P | 2006-05-19 | 2006-05-19 | |
US60/801,962 | 2006-05-19 | ||
US90039607P | 2007-02-09 | 2007-02-09 | |
US60/900,396 | 2007-02-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007136614A2 WO2007136614A2 (en) | 2007-11-29 |
WO2007136614A3 true WO2007136614A3 (en) | 2008-10-30 |
Family
ID=38723795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/011594 WO2007136614A2 (en) | 2006-05-19 | 2007-05-15 | Assays and methods for the diagnosis and progression of alzheimer's disease using a multi-analyte marker panel |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007136614A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ628281A (en) * | 2008-12-09 | 2016-05-27 | Stephanie Fryar Williams | Biomarkers for the diagnosis and/or prediction of susceptibility to mental and neurodegenerative disorders |
WO2011005893A2 (en) * | 2009-07-07 | 2011-01-13 | Abbott Laboratories | Biomarkers and methods for detecting alzheimer's disease |
WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
CN103827671B (en) * | 2011-05-03 | 2017-05-03 | 联邦科学与工业研究组织 | Method for detection of a neurological disease |
CN106202984B (en) * | 2016-08-26 | 2018-09-04 | 赵毅 | It is a kind of based on multilayer complex network to the screening technique of tumour miRNA marker |
CN108256423B (en) * | 2017-12-07 | 2021-11-16 | 广东技术师范大学 | Alzheimer disease feature extraction method and system based on overall correlation coefficient |
CN108256422B (en) * | 2017-12-07 | 2021-11-09 | 广东技术师范大学 | Alzheimer disease classification method, system and device based on Gaussian process classification |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5601985A (en) * | 1991-08-14 | 1997-02-11 | Trustees Of The Univ. Of Pennsylvania | Method of detecting abnormally phosphorylated tau(τ) |
US6465195B2 (en) * | 1999-12-30 | 2002-10-15 | Washington University | Predictive diagnostic for Alzheimer's disease |
US20050244890A1 (en) * | 2003-11-07 | 2005-11-03 | Davies Huw A | Biomarkers for Alzheimer's disease |
US20050256397A1 (en) * | 2002-03-20 | 2005-11-17 | Mony De Leon | Csf biomarker dilution factor corrections by mri imaging and algorithm |
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2007
- 2007-05-15 WO PCT/US2007/011594 patent/WO2007136614A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5601985A (en) * | 1991-08-14 | 1997-02-11 | Trustees Of The Univ. Of Pennsylvania | Method of detecting abnormally phosphorylated tau(τ) |
US6465195B2 (en) * | 1999-12-30 | 2002-10-15 | Washington University | Predictive diagnostic for Alzheimer's disease |
US20050256397A1 (en) * | 2002-03-20 | 2005-11-17 | Mony De Leon | Csf biomarker dilution factor corrections by mri imaging and algorithm |
US20050244890A1 (en) * | 2003-11-07 | 2005-11-03 | Davies Huw A | Biomarkers for Alzheimer's disease |
Also Published As
Publication number | Publication date |
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WO2007136614A2 (en) | 2007-11-29 |
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