WO2007114447A1 - Dispositif d'injection de liquide médical - Google Patents

Dispositif d'injection de liquide médical Download PDF

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Publication number
WO2007114447A1
WO2007114447A1 PCT/JP2007/057494 JP2007057494W WO2007114447A1 WO 2007114447 A1 WO2007114447 A1 WO 2007114447A1 JP 2007057494 W JP2007057494 W JP 2007057494W WO 2007114447 A1 WO2007114447 A1 WO 2007114447A1
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WO
WIPO (PCT)
Prior art keywords
injection
graph
chemical
pressure
time
Prior art date
Application number
PCT/JP2007/057494
Other languages
English (en)
Japanese (ja)
Inventor
Shigeru Nemoto
Original Assignee
Nemoto Kyorindo Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nemoto Kyorindo Co., Ltd. filed Critical Nemoto Kyorindo Co., Ltd.
Priority to JP2008508704A priority Critical patent/JPWO2007114447A1/ja
Publication of WO2007114447A1 publication Critical patent/WO2007114447A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546—Front-loading type injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/18—General characteristics of the apparatus with alarm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/281—Means for the use of in vitro contrast agents

Definitions

  • the present invention relates to a chemical injection device for injecting a chemical into a subject, and in particular, a CT (Computed Tomography) scanner or an MRI (Magnetic Magnetic).
  • a CT Computer Tomography
  • MRI Magnetic Magnetic
  • Such a chemical solution injection device has, for example, a piston drive mechanism including a drive motor and a slider mechanism, and a chemical solution syringe is detachably attached thereto.
  • the chemical syringe includes a cylinder member and a piston member that is slidably inserted into the slider member.
  • the cylinder member is filled with a chemical solution such as contrast medium or physiological saline.
  • the chemical injection device pushes the cylinder member into the piston member by the piston drive mechanism, thereby using the chemical syringe syringe.
  • a contrast medium is injected into the subject.
  • the liquid injection apparatus applies the contrast medium according to the input numerical values. Inject the subject. Since the contrast level of the subject changes due to the injection of the contrast agent, a good fluoroscopic image is taken by the fluoroscopic imaging device.
  • a contrast agent syringe filled with a contrast agent and a physiological saline syringe filled with physiological saline are mounted in parallel as a chemical solution syringe. It is.
  • the contrast syringe and the saline syringe are usually connected to the subject by a single bifurcated extension tube.
  • the chemical solution injection device receives the input data.
  • a contrast medium is injected into the subject and then physiological saline is also injected automatically.
  • the contrast agent can be boosted with physiological saline to reduce the consumption of the contrast agent, and the artifact can be reduced with the physiological saline.
  • the detected pressure rapidly decreases. Also, if the extension tube bends during the test injection, the detected pressure rises rapidly. Since the chemical injection device displays the pressure of the chemical to be injected in real time, the operator can judge the occurrence of abnormality by monitoring the pressure.
  • the test injection for confirming the connection state of the extension tube is performed by injection of a contrast medium in a chemical liquid injection apparatus in which only a contrast medium syringe is mounted, and the contrast medium syringe and the physiological saline syringe are connected.
  • the chemical injection device is usually implemented by injection of physiological saline.
  • test injection for confirming the time required for the contrast medium to reach the affected area is also executed.
  • contrast medium is injected at the same rate as normal injection, and the time required from the start of injection until the contrast medium reaches the affected area is measured.
  • an injection head to which a chemical solution syringe is attached;
  • the injection control unit in which display and input operations are executed is configured separately. Therefore, the injection head can be freely arranged in the vicinity of the subject, and the injection control unit can be arranged in the vicinity of the imaging control device of the fluoroscopic imaging device. [0012] In particular, when the fluoroscopic imaging apparatus is an MRI apparatus, the injection control unit with a built-in microcomputer cannot be arranged in the vicinity of the fluoroscopic imaging unit of the MRI apparatus. A structure that can be arranged separately from the control unit is useful.
  • the present applicant has a structure in which the injection head and the injection control unit are separated, and the test injection input operation and display are executed by the injection head, and the formal injection input operation and display are performed.
  • has been filed by inventing a chemical solution injection device that improves the workability of test injection and formal injection by executing the injection control unit see, for example, Patent Document 1).
  • Patent Document 1 Japanese Patent Application No. 2003-368859 (WO2005 / 039675A1)
  • the chemical injection device as described above displays the pressure of the chemical to be injected in real time, the operator can determine whether there is an abnormality by monitoring the pressure. However, in other words, if the operator does not monitor the pressure displayed by the chemical injection device, the occurrence of an abnormality will not be determined, and the burden on the operator is heavy and the detection of the occurrence of the abnormality may be delayed.
  • a predetermined allowable range is set for the chemical injection device with respect to the test injection pressure, and the chemical injection device detects an abnormality when the detected pressure deviates from the allowable range. it can.
  • the force that needs to be confirmed when the detected pressure changes suddenly while satisfying the allowable range, etc.
  • the chemical injection device as described above, the allowable range is satisfied even if the pressure changes suddenly. If so, the occurrence of an abnormality is not detected.
  • the present invention has been made in view of the above-described problems, and even when the pressure of the test injection is suddenly changed within a predetermined range or when the change pattern of the pressure is changed.
  • An object of the present invention is to provide a chemical liquid injector capable of detecting abnormal occurrences satisfactorily.
  • the chemical injection device of the present invention is a chemical liquid syringe force in which a piston member is slidably inserted into a cylinder member.
  • the chemical injection device is a piston drive mechanism, pressure detection means, graph generation means, graph storage means, graph comparison means, abnormality detection means, and warning notification means.
  • the piston drive mechanism pushes the piston member into the cylinder member.
  • the pressure detection means detects the pressure of the chemical solution injected into the subject.
  • the graph generating means generates the pressure detected during execution of the test injection in real time as a time graph.
  • the graph storage means stores a reference graph corresponding to the pressure when the test injection is properly executed.
  • the graph comparison means compares the shape of the time graph with the shape of the reference graph in real time.
  • the abnormality detection means detects the occurrence of an abnormality if the shape of the time-dependent graph is not similar to the shape of the reference graph.
  • the time-lapse graph and the reference graph are compared by the existing image recognition technology, and if the reference graph and the time-lapse graph are not similar, the occurrence of abnormality is detected. Therefore, the occurrence of an abnormality is detected even when the pressure of the test injection changes rapidly within a predetermined range or when the pressure change pattern is changed.
  • the various means referred to in the present invention may be formed so as to realize their functions!
  • dedicated hardware that exhibits a predetermined function, and a predetermined function provided by a computer program.
  • the various constituent elements referred to in the present invention are not necessarily required to be individually independent, but a plurality of constituent elements are formed as one member, and one constituent element includes a plurality of constituent elements. It is possible to be formed of members, a certain component is a part of another component, a part of a certain component overlaps a part of another component, etc. Brief description of the drawings
  • FIG. 1 is a schematic diagram showing a logical structure of a chemical liquid injector according to an embodiment of the present invention.
  • FIG. 2 is a block diagram showing a physical structure of a chemical solution injection system.
  • FIG. 3 is a perspective view showing an appearance of a chemical liquid injection system.
  • ⁇ 4 It is a perspective view showing the appearance of the chemical liquid injector.
  • ⁇ 5 A perspective view showing a state in which a chemical syringe is attached to the injection head of the chemical injection device.
  • ⁇ 6 A schematic cross-sectional view showing the internal structure of the injection head.
  • FIG. 7 is a diagram showing an example of a display screen of a sub touch panel that serves as both a sub operation panel and a sub display panel.
  • FIG. 8 is a diagram showing a state in which a schematic image of a body section and a blank condition screen are displayed on a main touch panel that serves as both a main operation panel and a main display panel.
  • FIG. 9 is a diagram showing a display screen of the main touch panel in a state where the body classification is selected.
  • FIG. 10 is a diagram showing a display screen of the main touch panel in a state in which an imaging region is selected and a condition image is displayed.
  • FIG. 11 is a flowchart showing an early part of the processing operation of the chemical injection device.
  • FIG. 12 is a flowchart showing the middle part of the processing operation of the chemical injection device.
  • FIG. 13 is a flowchart showing an end portion of the processing operation of the chemical liquid injector.
  • FIG. 14 is a flowchart showing a processing operation of an MRI apparatus which is a fluoroscopic imaging apparatus. Explanation of symbols
  • a chemical injection system 1000 includes a chemical injection device 100, a chemical syringe 200, and an MRI apparatus 300 that is a fluoroscopic imaging device. As will be described later, a contrast medium or the like is injected into the subject (not shown) as a drug solution.
  • the MRI apparatus 300 includes a fluoroscopic imaging unit 301 and an imaging control unit 302.
  • the fluoroscopic imaging unit 301 and the imaging control unit 302 are connected to each other through a communication network 303.
  • the fluoroscopic imaging unit 301 captures a fluoroscopic image from the subject, and the imaging control unit 302 controls the operation of the fluoroscopic imaging unit 301.
  • the chemical syringe 200 has a cylinder member 210 and a piston member 220 as shown in FIG.
  • the piston member 220 is slidably inserted into the cylinder member 210.
  • the cylinder member 210 has a cylindrical main body 211, and a conduit 212 is formed on the closed end face of the main body 211.
  • the end face of the main body 211 of the cylinder member 210 is opened, and the piston member 220 is inserted into the main body 211 from this opening.
  • a cylinder flange 213 is formed on the outer periphery of the cylinder member 210, and a piston flange 221 is formed on the outer periphery of the piston member 220.
  • the chemical injection device 100 of the present embodiment includes an injection control unit 101, and an injection head 110 that is an injection device body configured separately from the injection control unit 101. Yes.
  • Injection control unit 101 and injection head 110 are wire-connected with communication cable 102.
  • the injection head 110 drives the chemical solution syringe 200 to be attached to inject the chemical solution into the subject.
  • the injection control unit 101 controls the operation of the injection head 110.
  • the injection control unit 101 has a computer unit 120 built therein.
  • the computer unit 120 is also connected to the imaging control unit 302 of the MRI apparatus 300 through a communication network 304 by wire.
  • the injection control unit 101 includes a main operation panel 103, a main touch panel 104 that combines the operation unit and the main display panel, a speaker unit 105, and the like arranged on the front surface of the main body housing 106.
  • a separate controller unit 107 is wired with a connection cable 108.
  • the injection head 110 is attached to the upper end of the caster stand 111 via the movable arm 112. As shown in FIG. 5, the injection head 110 has a head main body 113, and a semicylindrical groove-shaped concave portion 114 that holds the chemical syringe 200 is formed on the upper surface of the head main body 113. ing.
  • a cylinder holding mechanism 116 that holds the cylinder flange 213 of the chemical liquid syringe 200 is formed in the front part of the recess 114.
  • a piston drive mechanism 130 that holds and slides the piston flange 221 is disposed behind the recess 114.
  • the cylinder holding mechanism 116 has a concave groove formed in the inner surface of the concave portion 114, and the cylinder flange 213 is engaged with the concave groove.
  • the two concave portions 114 of the injection head 110 are individually provided with a contrast medium syringe 200C filled with a contrast medium as a chemical solution and a physiological saline syringe 200P filled with a physiological saline solution as a chemical liquid! It is attached to.
  • the piston drive mechanism 130 is disposed corresponding to each recess 114.
  • the two recesses 114 and the two piston drive mechanisms 130 constitute a contrast medium injection mechanism 130C for injecting a contrast medium into a subject and a physiological saline injection mechanism 130P for injecting physiological saline.
  • the piston drive mechanism 130 has a slide rod 131 that is elongated in the front-rear direction as a slider member.
  • the slide rod 131 is supported by the head body 113 so as to be slidable in the front-rear direction in a state in which the slide rod 131 cannot rotate about the axis.
  • a piston pressing member 132 is formed in the body at the front end of the slide rod 131.
  • a pair of engaging claws 133 are attached to the piston pressing member 132 so as to be freely opened and closed.
  • a threaded hole 134 is formed in the slide rod 131 such that the center force on the rear surface is also directed forward.
  • a male screw 136 that engages with the screw hole 134 is formed on a screw shaft 137 that is a rotating member.
  • the screw shaft 137 is rotatably supported on the head body 113 by a radial bearing 138, and is supported by the thrust bearing 139 in the axial direction in a rotatable state. More specifically, an annular flange portion 141 is formed near the rear end of the screw shaft 137, and an annular thrust bearing 139 is in contact with the rear surface of the flange portion 141.
  • a load cell 142 having the same shape is in contact with the rear surface of the thrust bearing 139 as a pressure detection element.
  • the load cell 142 is a force fixed to the head main body 113.
  • the thrust bearing 139 is supported by the head main body 113 so as to be slightly displaceable in the front-rear direction.
  • the piston drive mechanism 130 has an ultrasonic motor 143 as a drive motor, and the ultrasonic motor 143 includes a belt mechanism 144 and a screw shaft 137 as shown in FIG. It is connected to. More specifically, a belt wheel 145 is attached to the rear end of the screw shaft 137, and a belt wheel is also attached to the rotor member of the ultrasonic motor 143 (not shown). An endless belt 146 is stretched around these belt wheels 145.
  • each part of the injection head 110 is formed of a nonmagnetic material, and a portion that cannot be formed of a nonmagnetic material is shielded.
  • the ultrasonic motor 143 has phosphor bronze alloy (Cu + Sn + P), titanium alloy ( ⁇ -6 ⁇ ⁇ 4V), magnesium alloy (Mg + Al + Zn), It is made of non-magnetic metal such as.
  • the load cell 142, the screw, the shaft 137, etc. are made of non-magnetic metal.
  • the belt mechanism 144 and the head body 113 are made of non-magnetic grease.
  • the main operation panel 103, the load cell 142, and the like are connected to the computer unit 120, and each part is integrated and controlled in accordance with the computer program installed in the computer unit 120 force. To do. Because of this, injection control The computer unit 120 controls the operation of the piston drive mechanism 130 of the injection head 110 in response to input operations of the main operation panel 103, main touch panel 104, and controller unit 107 of the unit 101, and various data related to this control are stored in the computer. The unit 120 is displayed on the main touch panel 104.
  • a sub-touch panel 118 serving as both a sub-operation panel and a sub-display panel is attached to the side of the injection head 110!
  • the computer unit 120 also controls the operation of the piston drive mechanism 130 of the injection head 110 and displays various data related to this control on the sub-touch panel 118 even when the sub-touch panel 118 is input.
  • the force sub-touch panel 118 which will be described in detail later, has a smaller screen size and fewer pixels than the main touch panel 104, the amount of data that can be displayed is small. For this reason, all of the various data that need to be displayed is displayed on the main touch panel 104. Only a part is displayed on the sub touch panel 118.
  • the computer unit 120 includes a CPU (Central Processing Unit) 121, a ROM (Read Only Memory) 122, a RAM (Rando m
  • a dedicated computer program is mounted on an information storage medium such as the ROM 122 by firmware or the like, and the CPU 121 executes various processing operations corresponding to the computer program.
  • the chemical injection device 100 of this embodiment stores various data of formal injection on the main touch panel 104.
  • the input operation is performed and displayed on the main touch panel 104, and various data of the test injection are input on the sub touch panel 118 and displayed on the sub touch panel 118.
  • the control data of the piston drive mechanism 130 specially designed for confirming the connection state of the extension tube 230 is registered as various types of test injection data.
  • the test touch start command is input to the sub touch panel 118. Then, the operation of the ultrasonic motor 143 of the physiological saline injection mechanism 130P is controlled corresponding to the test injection control data.
  • the chemical injection device 100 of the present embodiment is configured such that the computer unit 120 operates in response to the computer program and the control data for the test injection, so that the pressure detection means 151, the graph generation means 152, the graph storage Means 153, graph display means 154, graph comparison means 156, abnormality detection means 157, warning notification means 158, drive control means 159, input operation means 161, graph registration means 162, etc.
  • Each of these means uses hardware such as the load cell 142 and the sub-touch panel 104 as a part if necessary, but basically the CPU 121 performs predetermined data processing corresponding to the computer program in the ROM 122. It corresponds to the function to execute.
  • the pressure detection means 151 detects the pressure of the chemical solution injected into the subject from the detection pressure of the load cell 142.
  • the graph generating means 152 generates the pressure detected during the test injection in real time as a time graph.
  • the graph storage means 153 corresponds to a storage area of the RAM 123 constructed so that the CPU 121 can recognize, and stores a reference graph corresponding to the pressure when the test injection is properly executed.
  • the graph display means 154 displays the stored reference graph on the sub-touch panel 118 and also displays the generated time-lapse graph in real time.
  • the graph comparison means 156 compares the shape of the time-lapse graph with the shape of the reference graph in real time using an existing image recognition technique or the like.
  • the abnormality detection means 157 detects the occurrence of an abnormality if the shape of the time graph and the reference graph are not similar.
  • the warning notification unit 158 displays that the abnormality has occurred on the main touch panel 104 and the sub touch panel 118 and outputs the sound from the speaker unit 105 as a sound. Will issue a warning.
  • the drive control means 159 controls the operation of the piston drive mechanism 130 corresponding to the reference graph when the test injection is executed, and forcibly stops the piston drive mechanism 130 when an abnormality is detected by the abnormality detection means 157.
  • the input operation unit 161 sets the abnormality detection unit 157 in a state in which an abnormality has been detected in response to a predetermined input operation to the sub-touch panel 118.
  • the graph registration means 162 is a sub-touch By a predetermined input operation on the panel 118, the time graph is registered in the graph storage means 153 as a reference graph.
  • the various means of the chemical solution injection device 100 as described above are forces realized by using hardware such as the main touch panel 104 as necessary.
  • the main body is a computer program stored in an information storage medium such as the ROM 122. This is realized by the function of the CPU 121, which is hardware, corresponding to the above.
  • Such a computer program stores, for example, a reference graph corresponding to the pressure when the test injection is properly executed in the RAM 123, and the piston corresponding to the reference graph when the test injection is executed.
  • Control the operation of the drive mechanism 130 detect the pressure of the chemical injected into the subject during the test injection from the detection pressure of the load cell 142, generate the detected pressure in real time as a graph over time, subtouch panel Display the reference graph in 118 and display the time graph in real time, compare the shape of the time graph with the shape of the reference graph in real time using existing image recognition technology, etc., and the shape of the time graph and the reference graph are similar Otherwise, the occurrence of an abnormality will be detected and the corresponding input operation to the sub touch panel 118 will be supported.
  • the main touch panel 104 and sub touch panel 118 display and the sound of the speaker unit 105 will give a warning, and if an abnormality is detected, the piston will drive.
  • processing operations such as forcibly stopping the mechanism 130 and registering a time-dependent graph as a reference graph by a predetermined input operation to the sub-touch panel 118, it is stored in an information storage medium such as the RAM 123. Stored.
  • the injection head 110 of the liquid injector 100 is arranged in the vicinity of the fluoroscopic imaging unit 301 of the MRI apparatus 300 as shown in FIG.
  • the injection control unit 101 is disposed at a predetermined position away from the fluoroscopic imaging unit 301.
  • Step Sl the operator moves from the vicinity of the injection head 110 to the vicinity of the injection control unit 101, and activates the chemical injection device 100 by an input operation on the main operation panel 103 or the like. Then, as shown in FIG. 8 and FIG. 11, a schematic image of a plurality of body sections is displayed on the upper part of the main touch panel 104 corresponding to the human body shape, and the injection rate of the medicinal solution is displayed below it. A horizontally long condition screen with the vertical axis and injection time on the horizontal axis is displayed (Step Sl).
  • step S2 when one of the schematic images of the plurality of body sections displayed on the main touch panel 104 is selected by the operator touching with a finger (step S2), the selection is performed as shown in FIG. Only the schematic image of the selected body section is brightened and the other schematic images are darkened, and the schematic image of the scanner mechanism is displayed above the schematic image of the selected body section.
  • a schematic image of a plurality of imaging regions related to the selected body segment is read and displayed at the bottom (steps S3 and S4), one of which is manually performed by the operator.
  • step S5 When selected by touching (step S5), as shown in FIG. 10, only one selected schematic image is brightened and the other schematic images are darkened.
  • step S7 When an imaging region is selected as described above, in the chemical injection device 100 of the present embodiment, it is confirmed whether or not a plurality of types of chemical syringes 200 are registered in the RAM 123 corresponding to the imaging region (step If a plurality of types of liquid syringes 200 are registered, product names and capacities that are identification data are listed in the main touch panel 104 and the sub touch panel 118 (step S7).
  • the display data of the selected chemical syringe 200 is erased, and the display data of only the selected chemical syringe 200 is expanded, so that the operator confirms the selection result of the chemical syringe 200 with certainty. can do.
  • the liquid injector 100 of the present embodiment stores the liquid syringe 200 that was used last time, and the liquid syringe 200 that was used last time is displayed by blinking or inversion when displayed as a list. The operator can easily execute the selection operation when the chemical syringe 200 to be used is the same as the previous one.
  • the selection operation of the chemical syringe 200 can also be performed on the sub-touch panel 118 of the injection head 110, the contrast medium syringe 200C and the physiological saline syringe 200P that are actually attached to the injection head 110 are installed. It is also possible to execute the selection operation with the sub touch panel 118 while confirming.
  • step S6 If only the contrast medium syringe 200C and the physiological saline syringe 200P force type are registered corresponding to the imaging site (step S6), the various types of data of the drug syringe 200 are automatically read out.
  • the product name, capacity, etc. are enlarged and displayed on the main touch panel 104 and the sub touch panel 118 (step S9).
  • the previous injection conditions for the formal injection correspond to the imaging region and the chemical syringe 200. It is confirmed whether it is registered in RAMI 23 (step S 10), registered !, na! /, And the default injection conditions are read (step Sl l). The injection condition is read (step S12).
  • the contrast agent and the physiological saline are sequentially used in the formal injection.
  • the injection conditions of contrast medium and physiological saline are registered so that this injection is executed. Since the injection time and the injection rate are set as data for the injection conditions read out in this way, the injection time and the injection speed are multiplied to calculate the injection volume for each injection condition (step S13).
  • a condition image in which the injection speed and the injection volume are given as text data in a width corresponding to the injection time is generated for each injection condition (step S14), and as shown in FIG.
  • the image is displayed and output on the condition screen at a vertical position corresponding to the injection speed and a horizontal position corresponding to the injection time (step S17).
  • the condition image is also generated for the injection condition force of the contrast medium and the physiological saline as described above.
  • the condition image is displayed and output in green and blue, and sequentially in the horizontal direction. Are displayed and output.
  • it is determined for each injection condition whether the injection speed exceeds the upper limit speed (step S15) .If the injection speed exceeds, the condition image flashes in red and a speed warning is issued. Is output (step S16).
  • the chemical injection device 100 of the present embodiment can change the injection conditions displayed on the main touch panel 104 as described above by operating the main touch panel 104 as desired. Yes (Steps S18, S19).
  • the injection speed of the injection condition can be increased or decreased by bringing the finger into contact with the center of the condition image displayed on the main touch panel 104 and sliding the contacted finger up or down on the condition image. .
  • the injection time and the injection volume of the injection conditions can be increased or decreased by bringing a finger into contact with at least one of the left and right ends of the displayed condition image and sliding the contacted finger to the left or right.
  • an operation image of the numeric keypad is displayed there (not shown). The rate and volume of injection can be increased or decreased.
  • step S18 when the injection condition for formal injection is input by the condition image displayed on the main touch panel 104 (step S18), this is stored as the current injection condition (step S12). A condition image is generated in real time corresponding to the condition (steps 313 to 319).
  • the injection conditions for formal injection are determined as described above.
  • the force registered in the RAM 123 as the reference graph is confirmed as the time chart of the test injection (step S20).
  • the time graph is registered, in this case, the default graph corresponding to the imaging region and the chemical syringe 200 is read, and the reference graph is read and displayed on the sub touch panel 118 (step S23). ). On the other hand, if a time-dependent graph is registered corresponding to the imaging region and the chemical syringe 200, the time-dependent graph is read and displayed as a reference graph on the sub-touch panel 118 (step S21).
  • the sub-touch panel 118 “executes test injection with user settings.
  • the default reference graph and the time graph registered as the reference graph are displayed along with guidance messages such as “YZN”. For this reason, the operator can also select and operate the power to use the registered time graph or the default reference graph on the sub touch panel 118 (step S22).
  • step S24 initial setting and test injection are performed (step S25 ⁇ ).
  • the computer unit 120 acquires electrical resistance as an electrical signal from the load cell 142 without operating the ultrasonic motor 143 of the physiological saline injection mechanism 130P and the design injection mechanism 130C (step S25).
  • the initial setting is executed assuming that the electric resistance indicates a pressure of “0” V (step S26).
  • the computer unit 120 executes test injection by operating the ultrasonic motor 143 only for the physiological saline injection mechanism 130P corresponding to the reference graph (step S27).
  • the screw shaft 137 connected by the ultrasonic motor 143 and the belt mechanism 144 is rotationally driven.
  • the screw shaft 137 is driven by the load cell 142 fixed to the head body 113. Since it is supported in the axial direction through the thrust bearing 139, the slide rod 131 connected to the screw shaft 137 by the screw mechanism is slid. Accordingly, the piston member 220 is pushed into the cylinder member 210 by the slide rod 131, and the chemical solution is injected from the cylinder member 210 to the subject.
  • the pressure acting on the slide rod 131 that presses the piston member 220 also acts on the screw shaft 137, so that the pressure acting on the screw shaft 137 acts on the load cell 142 via the thrust bearing 139.
  • the computer unit 120 obtains the pressure detected by the load cell 142 during the execution of the chemical solution injection as described above (step S28), and the initial value of the chemical solution set by the syringe selection is obtained.
  • the viscosity corresponds to the inner diameter of the cylinder member 210 and the like, and the pushing pressure of the piston member 220 is converted into the chemical injection pressure (step S29).
  • the operator can easily confirm the injection pressure of the chemical solution that does not need to analogize the injection pressure of the chemical solution from the pressure acting on the piston member 220. it can.
  • the various data necessary to convert the pressure of the piston member 220 into the injection pressure of the chemical solution is set just by selecting and operating the chemical syringe 200 listed as described above (Step S8, S9), no complicated data input is required for the operator.
  • this injection pressure force time graph is generated in real time and displayed on the sub-touch panel 118 (step S30), the operator can actually carry out the chemical solution injected in the test. It can be easily confirmed in real time whether the injection pressure of the gas corresponds to the reference graph.
  • the upper limit pressure of the test injection is also set by default corresponding to the imaging site and the chemical syringe 200, so that the injection pressure is increased during the test injection. Whether or not the upper limit pressure is exceeded is constantly monitored (step S31). If the injection pressure exceeds the upper limit pressure, an abnormality is output from the main touch panel 104 and sub touch panel 118 display and the audio output of the speaker unit 105 (step S35), and the physiological saline injection mechanism 130P is activated. Is forcibly stopped (step S36). For this reason, the operator can quickly and reliably recognize that an abnormal pressure has occurred in the test injection, and automatically prevent the test injection from continuing while the abnormal pressure is generated.
  • the chemical injection device 100 of the present embodiment corresponds to the physiological saline injection mechanism corresponding to the reference graph. Since the test injection is executed by driving 130P, if the test injection is executed normally, the shape of the graph over time is similar to the shape of the reference graph. Therefore, for example, the computer unit 120 compares the shape of the graph over time with the shape of the reference graph in real time using the existing image recognition technology (step S32), and an abnormality occurs when the shapes of both graphs are similar. Is detected.
  • the time-lapse graph rapidly decreases in a short time.
  • the time graph is originally higher than the reference graph, the occurrence of an abnormality may not be detected from the difference from the pressure of the reference graph even if the pressure of the time graph decreases.
  • the occurrence of an abnormality is detected if the shape of the reference graph and the shape of the time-dependent graph are not similar, and thus the occurrence of an abnormality is detected even if the pressure difference is not sufficient as described above can do.
  • a sufficient pressure difference is generated between the reference graph and the time-lapse graph, it is determined that the shapes are not similar, and thus an abnormality is detected.
  • a recognition technique used in OCR (Optical Character Reader) or the like can be used as a technique for determining the similarity in shape between the reference graph and the time-dependent graph.
  • test injection pressure can also be adjusted in real time (step S27). Since the manually operated time graph is not compared with the reference graph (step S33), the test injection may be performed in a state where the time graph is not similar to the reference graph according to the operator's request. it can.
  • the time-lapse dull is displayed in real time together with the reference graph as described above, so that the occurrence of abnormality is determined by the operator's judgment on the sub touch panel. It is also possible to perform an input operation on the button 118 (step S34). Even in that case, since the operation of the physiological saline injection mechanism 130P is forcibly stopped (step S36), the time graph determined to be abnormal by the operator is not registered as the reference graph.
  • step S36 when the test injection is interrupted due to the occurrence of an abnormality (step S36), as shown in FIG. 11, the state force operation with the selected imaging region can be resumed. (Step S6) The test injection can be resumed quickly without the need for unnecessary input operations.
  • step S37 the above-described test injection operation is repeated (steps S27 to S37) until the completion of the injection is detected for the force such as the working distance of the physiological saline injection mechanism 130P (step S37).
  • step S37 the operation of the physiological saline injection mechanism 130P is stopped (step S38).
  • a guidance message such as “Do you want to register this injection graph as a reference graph for the next and subsequent times? YZN” is displayed with the reference graph and time graph displayed. Is done. Therefore, when the operator determines that the time graph of the current test injection is registered more appropriately than the current reference graph, the operator manually operates “Y” (step S39).
  • step S40 since the current time graph is registered as the reference graph (step S40), the time graph in which the next force is also registered can be used as the reference graph (steps S20 to S23). Therefore, a time-lapse graph that has been confirmed to be similar to the current reference graph without exceeding the upper limit pressure (steps S31 and S33) can be registered as a new reference graph as desired by the operator (step S40). ).
  • Step S32 Even when a time graph that is not similar to the reference graph is generated manually by the operator (step S32), the time graph can be registered as a new reference graph as desired by the operator. (Step S40). In particular, even if the test injection is manually operated as desired by the operator, the injection pressure is limited to a range that does not exceed the upper limit pressure (step S31), so the test injection is executed at an abnormal pressure. (Step S 36) Dangerous time graphs may not be registered as reference graphs! /.
  • the time-lapse graph registered as the reference graph is registered corresponding to the imaging region and the chemical syringe 200, and if the imaging region and the chemical syringe 200 are selected and operated as described above (Steps S1 to S8). ), The corresponding reference graph is automatically read out (steps S20 to S23), so that the reference graph corresponding to the imaging region and the drug solution syringe 200 can be easily registered and read out.
  • step S41 to S41 the chemical injection device 100 of the present embodiment is in a state in which formal injection can be executed.
  • the operator also moves the vicinity force of the injection head 110 to the vicinity of the injection control unit 101, and inputs a start operation of formal injection to the main touch panel 104.
  • the chemical injection device 100 that has detected this step S41) transmits a work start to the MRI apparatus 300 (step S44).
  • the MRI apparatus 300 that has received the work start from the chemical injection device 100 in this way (step T2) returns the work start to the chemical injection device 100 and executes the imaging operation ( Step ⁇ 8). For this reason, in the chemical injection system 1000 of this embodiment, the imaging of the MRI apparatus 300 follows the chemical injection of the chemical injection apparatus 100.
  • the chemical injection device 100 is in a state where preparation for normal injection is completed (steps S41 to S43), and as shown in FIG.
  • the start of imaging is input (step Tl)
  • the MRI 300 The liquid injection of the liquid injection device 100 follows (steps T4, T6 ⁇ , S42, S47 ⁇ ).
  • step S48 when the chemical injection device 100 performs a series of chemical injection operations (from step S48), the injection start force is also measured for the elapsed time (step S48), and the elapsed time
  • step S49 The contrast medium injection mechanism 130C and the physiological saline injection mechanism 130P are sequentially controlled in real time in accordance with the read injection conditions (step S49).
  • the computer unit 120 obtains the pressure detected by the load cell 142 (step S50), and injects the piston pressure corresponding to the initial viscosity of the chemical solution corresponding to the inner diameter of the cylinder member 210, etc. (Step S51) and confirms that this injection pressure is normal (step S52).
  • the chemical injection device 100 and the MRI device 300 of the present embodiment detect the occurrence of abnormality in the above-mentioned ready state (steps S43, T3), or detect the occurrence of abnormality during operation execution. (Steps S52 and T9), the occurrence of the abnormality is output (Steps S55 and T16), and the operation is stopped (Steps S58 and T18).
  • Steps S54, T15 since the occurrence of the abnormality is also transmitted to the other side (Steps S54, T15), the other side that has received this (Steps T10, S44) also outputs an abnormality occurrence (Steps T16, S46). Also, since one operation stop is also sent to the other (steps S56, T17), the other operation that received this (steps T13, S53) executes the operation stop (steps T18, S57).
  • step S58, Tl l Even when an operation stop is input to one side (step S58, Tl l), the operation stop is executed (step S57, T18) and also sent to the other (step S56). ⁇ ) 17) Even if the other side receives this (step T13, S60), the operation is stopped (step T18, S57) 0
  • step S61 and T14 When the operation completion is detected on one side (steps S61 and T14), the operation end is executed (steps S62 and T19), and the operation end is transmitted to the other side (steps 61). flop S63, T20), the other at even (step Tl 2 which has received this, S59), stops the operation (step T18, S57) 0
  • the drug solution injection of the drug solution injection device 100 and the imaging of the MRI device 300 are automatically linked, so that the contrast agent and the physiological saline are separated. It is possible to take a fluoroscopic image of a subject who is injected in order at an appropriate timing at an appropriate timing.
  • the piston drive mechanism 130 is supported by the head main body 113 so as to be displaceable, and the port cell 142 for detecting the pressure acting on the piston drive mechanism 130 is the head main body 113. It is fixed to. For this reason, since the load cell 142 is arranged in the movable part of the piston drive mechanism 130, the structure is simple and the productivity and reliability are good.
  • the present invention is not limited to the above embodiment, and various modifications are allowed without departing from the scope of the present invention.
  • the chemical injection device 100 having the contrast medium injection mechanism 130C and the physiological saline injection mechanism 130P is exemplified to inject the contrast medium and the physiological saline.
  • a chemical solution injection device (not shown) for injecting only the agent can also be implemented.
  • the chemical injection device 100 having the contrast medium injection mechanism 130C and the physiological saline injection mechanism 130P performs the test injection with the physiological saline.
  • a test injection with a contrast agent.
  • the control data of the piston drive mechanism 130 specialized for confirming the time required for the contrast medium to reach the affected part where the fluoroscopic image is taken is registered in the computer unit 120 as various data of the test injection.
  • the operation of the piston drive mechanism 130 can be controlled in accordance with the control data.
  • the main touch panel 104 and the sub touch panel 118 execute the input operation and display of formal injection and test injection.
  • the chemical injection device 100 is connected online to the host computer of the manufacturer of the chemical syringe 200, and various data are online to the chemical injection device 100 each time a new chemical syringe 200 is shipped. It is also possible to provide it with (not shown).
  • the pressure of the piston member 220 is converted into the injection pressure of the chemical liquid based on various data of the chemical liquid syringe 200.
  • a load cell inside the cylinder member 210 or the extension tube 230 (not shown), it is possible to directly detect the injection pressure of the chemical solution.
  • At least one chemical syringe 200 is registered for each imaging region, and when there are a plurality of registered chemical syringes 200, a list is displayed and an operator performs a selection operation. did. However, only one chemical syringe 200 is registered for each imaging region, and syringe data can be automatically read when an imaging region is selected.
  • the MRI apparatus 300 is used as the fluoroscopic imaging apparatus, and the liquid injector 100 injects the MR contrast agent.
  • a CT scanner or PET device is used as a fluoroscopic imaging device, and a contrast medium for that is injected by a chemical injection device. Is also possible.
  • each of these various means can be formed as unique hardware, and a part thereof can be stored as software in the RAM 123 or the like and a part can be formed as nodeware.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Selon l'invention, un système de création de graphique (152) produit une pression d'injection à détecter au cours de l'exécution d'une injection d'essai sous la forme d'un graphique d'évolution au cours du temps en temps réel. Un graphique de référence correspondant à la pression d'injection à l'instant où l'injection d'essai est convenablement exécutée, est enregistré dans un système de mémoire de graphiques (153). La forme du graphique de référence et la forme du graphique d'évolution au cours du temps sont comparées en temps réel par un système de comparaison de graphiques (156). Si les formes de ces deux graphiques ne sont pas similaires, une occurrence d'anomalie est détectée par un système de détection d'anomalie (157).
PCT/JP2007/057494 2006-04-06 2007-04-03 Dispositif d'injection de liquide médical WO2007114447A1 (fr)

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008126854A1 (fr) * 2007-04-10 2008-10-23 Nemoto Kyorindo Co., Ltd. Dispositif d'injection de liquide chimique
WO2010014654A1 (fr) * 2008-07-29 2010-02-04 Mallinckrodt Inc. Cassette à seringues multiples
WO2010119919A1 (fr) * 2009-04-15 2010-10-21 株式会社根本杏林堂 Distributeur de solution chimique
JP2011502702A (ja) * 2007-11-19 2011-01-27 マリンクロッド・インコーポレイテッド 圧力監視を用いた開存性チェックを有するパワーインゼクタ
JP2013025098A (ja) * 2011-07-21 2013-02-04 Icst:Kk 注射器練習装置
JP2017109122A (ja) * 2011-02-01 2017-06-22 株式会社根本杏林堂 薬液注入装置
JP2022512141A (ja) * 2018-12-10 2022-02-02 フェッター ファルマ－フェルティグング ゲーエムベーハー ウント コンパニー カーゲー 力測定アセンブリ、このような力測定アセンブリを備えた力測定装置およびこのような力測定アセンブリを用いた方法
JP2022512142A (ja) * 2018-12-10 2022-02-02 フェッター ファルマ－フェルティグング ゲーエムベーハー ウント コンパニー カーゲー 力測定装置に試験装置ホルダを取り付けるための取付けアセンブリ、このような取付けアセンブリを備えた力測定装置、試験装置ホルダおよび力測定装置のためのスライダ部材
US11369723B2 (en) * 2017-05-16 2022-06-28 Fresenius Medical Care Deutschland Gmbh Peritoneal dialysis machine

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JP2004298550A (ja) * 2003-04-01 2004-10-28 Nemoto Kyorindo:Kk 薬液注入システム
WO2005039675A1 (fr) * 2003-10-29 2005-05-06 Nemoto Kyorindo Co., Ltd Dispositif de perfusion de liquide medicinal
WO2005084732A1 (fr) * 2004-03-03 2005-09-15 Nemoto Kyorindo Co., Ltd. Systeme d'injection de solution medicale

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Publication number Priority date Publication date Assignee Title
JP2004298550A (ja) * 2003-04-01 2004-10-28 Nemoto Kyorindo:Kk 薬液注入システム
WO2005039675A1 (fr) * 2003-10-29 2005-05-06 Nemoto Kyorindo Co., Ltd Dispositif de perfusion de liquide medicinal
WO2005084732A1 (fr) * 2004-03-03 2005-09-15 Nemoto Kyorindo Co., Ltd. Systeme d'injection de solution medicale

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008126854A1 (fr) * 2007-04-10 2008-10-23 Nemoto Kyorindo Co., Ltd. Dispositif d'injection de liquide chimique
JP2011502702A (ja) * 2007-11-19 2011-01-27 マリンクロッド・インコーポレイテッド 圧力監視を用いた開存性チェックを有するパワーインゼクタ
WO2010014654A1 (fr) * 2008-07-29 2010-02-04 Mallinckrodt Inc. Cassette à seringues multiples
WO2010119919A1 (fr) * 2009-04-15 2010-10-21 株式会社根本杏林堂 Distributeur de solution chimique
JP2017109122A (ja) * 2011-02-01 2017-06-22 株式会社根本杏林堂 薬液注入装置
JP2021090794A (ja) * 2011-02-01 2021-06-17 株式会社根本杏林堂 薬液注入装置
US20140127661A1 (en) * 2011-07-21 2014-05-08 Icst Corporation Syringe operation practice device
JP2013025098A (ja) * 2011-07-21 2013-02-04 Icst:Kk 注射器練習装置
US11369723B2 (en) * 2017-05-16 2022-06-28 Fresenius Medical Care Deutschland Gmbh Peritoneal dialysis machine
JP2022512141A (ja) * 2018-12-10 2022-02-02 フェッター ファルマ－フェルティグング ゲーエムベーハー ウント コンパニー カーゲー 力測定アセンブリ、このような力測定アセンブリを備えた力測定装置およびこのような力測定アセンブリを用いた方法
JP2022512142A (ja) * 2018-12-10 2022-02-02 フェッター ファルマ－フェルティグング ゲーエムベーハー ウント コンパニー カーゲー 力測定装置に試験装置ホルダを取り付けるための取付けアセンブリ、このような取付けアセンブリを備えた力測定装置、試験装置ホルダおよび力測定装置のためのスライダ部材
JP7439090B2 (ja) 2018-12-10 2024-02-27 フェッター ファルマ－フェルティグング ゲーエムベーハー ウント コンパニー カーゲー 力測定装置に試験装置ホルダを取り付けるための取付けアセンブリ、このような取付けアセンブリを備えた力測定装置、試験装置ホルダおよび力測定装置のためのスライダ部材
JP7439089B2 (ja) 2018-12-10 2024-02-27 フェッター ファルマ－フェルティグング ゲーエムベーハー ウント コンパニー カーゲー 力測定アセンブリ、このような力測定アセンブリを備えた力測定装置およびこのような力測定アセンブリを用いた方法

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