WO2007092740A3 - Method and system for the amplification of nuclear magnetic resonance imaging - Google Patents

Method and system for the amplification of nuclear magnetic resonance imaging Download PDF

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Publication number
WO2007092740A3
WO2007092740A3 PCT/US2007/061483 US2007061483W WO2007092740A3 WO 2007092740 A3 WO2007092740 A3 WO 2007092740A3 US 2007061483 W US2007061483 W US 2007061483W WO 2007092740 A3 WO2007092740 A3 WO 2007092740A3
Authority
WO
WIPO (PCT)
Prior art keywords
contrast
mri
feedback
amplification
magnetic resonance
Prior art date
Application number
PCT/US2007/061483
Other languages
French (fr)
Other versions
WO2007092740A2 (en
Inventor
Yung-Ya Lin
Susie Y Huang
Original Assignee
Univ California
Yung-Ya Lin
Susie Y Huang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Yung-Ya Lin, Susie Y Huang filed Critical Univ California
Publication of WO2007092740A2 publication Critical patent/WO2007092740A2/en
Publication of WO2007092740A3 publication Critical patent/WO2007092740A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/565—Correction of image distortions, e.g. due to magnetic field inhomogeneities
    • G01R33/56563—Correction of image distortions, e.g. due to magnetic field inhomogeneities caused by a distortion of the main magnetic field B0, e.g. temporal variation of the magnitude or spatial inhomogeneity of B0
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/36—Electrical details, e.g. matching or coupling of the coil to the receiver

Landscapes

  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

A method and system to enhance MRI contrast based on nonlinear feedback fields induced by the spin of the imaged molecules are provided. It is shown that while contrast in magnetic resonance imaging (MRI) is often limited by the dependence of the magnetization on MR parameters that may not vary significantly throughout the sample, through use of the inventive system, changes in the distribution of an initially unstable magnetization configuration act back on the spins through the feedback fields to amplify contrast. Demonstrations of avalanching amplification of MRI contrast due to small differences in spin density or resonance frequency under the feedback interactions of the distant dipolar field and/or radiation damping in phantoms and in vitro human brain tissue are also provided. These demonstrations show up to 20 times improved contrast in epileptogenic lesions and malignant brain tumors, tissues with minimal contrast differences in routine MRI, which suggests that feedback-based contrast enhancement may lead to improved lesion characterization, among other potential biomedical applications.
PCT/US2007/061483 2006-02-07 2007-02-01 Method and system for the amplification of nuclear magnetic resonance imaging WO2007092740A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77128306P 2006-02-07 2006-02-07
US60/771,283 2006-02-07

Publications (2)

Publication Number Publication Date
WO2007092740A2 WO2007092740A2 (en) 2007-08-16
WO2007092740A3 true WO2007092740A3 (en) 2008-01-17

Family

ID=38345878

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/061483 WO2007092740A2 (en) 2006-02-07 2007-02-01 Method and system for the amplification of nuclear magnetic resonance imaging

Country Status (1)

Country Link
WO (1) WO2007092740A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101609132A (en) * 2008-06-19 2009-12-23 西门子公司 Determine that the control high frequency sends the method and the magnetic resonance equipment of the pulse train of coil

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012230778A1 (en) * 2011-03-23 2013-10-10 Millikelvin Technologies Llc Improved techniques, systems and machine readable programs for magnetic resonance
JP2015528719A (en) * 2012-07-02 2015-10-01 ミリケルヴィン テクノロジーズ エルエルシーＭｉｌｌｉｋｅｌｖｉｎ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ Improved techniques, systems and machine readable programs for magnetic resonance

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910460A (en) * 1988-12-05 1990-03-20 University Of Medicine & Dentistry Of New Jersey Method and apparatus for mapping eddy currents in magnetic resonance imaging
US20010037063A1 (en) * 2000-03-29 2001-11-01 Albert Mitchell S. Low-field MRI
US6477398B1 (en) * 1997-11-13 2002-11-05 Randell L. Mills Resonant magnetic susceptibility imaging (ReMSI)
US20030219385A1 (en) * 2002-03-07 2003-11-27 Eric Ahrens Contrast agents for magnetic resonance imaging and methods related thereto
US20040010191A1 (en) * 2000-08-11 2004-01-15 Yumiko Yatsui Magnetic resonance imaging device and method
US20040142496A1 (en) * 2001-04-23 2004-07-22 Nicholson Jeremy Kirk Methods for analysis of spectral data and their applications: atherosclerosis/coronary heart disease
US20050008572A1 (en) * 2003-04-29 2005-01-13 Ales Prokop Nanoparticular tumor targeting and therapy

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910460A (en) * 1988-12-05 1990-03-20 University Of Medicine & Dentistry Of New Jersey Method and apparatus for mapping eddy currents in magnetic resonance imaging
US6477398B1 (en) * 1997-11-13 2002-11-05 Randell L. Mills Resonant magnetic susceptibility imaging (ReMSI)
US20010037063A1 (en) * 2000-03-29 2001-11-01 Albert Mitchell S. Low-field MRI
US20040010191A1 (en) * 2000-08-11 2004-01-15 Yumiko Yatsui Magnetic resonance imaging device and method
US20040142496A1 (en) * 2001-04-23 2004-07-22 Nicholson Jeremy Kirk Methods for analysis of spectral data and their applications: atherosclerosis/coronary heart disease
US20030219385A1 (en) * 2002-03-07 2003-11-27 Eric Ahrens Contrast agents for magnetic resonance imaging and methods related thereto
US20050008572A1 (en) * 2003-04-29 2005-01-13 Ales Prokop Nanoparticular tumor targeting and therapy

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101609132A (en) * 2008-06-19 2009-12-23 西门子公司 Determine that the control high frequency sends the method and the magnetic resonance equipment of the pulse train of coil
CN101609132B (en) * 2008-06-19 2013-08-21 西门子公司 Magnetic resonance apparatus and method for determining a pulse sequence to control an RF radiating coil

Also Published As

Publication number Publication date
WO2007092740A2 (en) 2007-08-16

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