WO2007026041A3 - Compuestos 1,4 antraquinonicos, su procedimiento de obtencion y su aplicacion como antiumorales. - Google Patents

Compuestos 1,4 antraquinonicos, su procedimiento de obtencion y su aplicacion como antiumorales. Download PDF

Info

Publication number
WO2007026041A3
WO2007026041A3 PCT/ES2006/000499 ES2006000499W WO2007026041A3 WO 2007026041 A3 WO2007026041 A3 WO 2007026041A3 ES 2006000499 W ES2006000499 W ES 2006000499W WO 2007026041 A3 WO2007026041 A3 WO 2007026041A3
Authority
WO
WIPO (PCT)
Prior art keywords
sus
quinónicos
antitumorales
obtención
aplicaciones
Prior art date
Application number
PCT/ES2006/000499
Other languages
English (en)
French (fr)
Other versions
WO2007026041A2 (es
Inventor
Orden Maria Teresa Molina
Sun Honghao
Chamudis Sandra Taliansky
Moya Amancio Carnero
Rodriguez Fernando Blanco
Ocana Maria Victoria Moneo
Original Assignee
Consejo Superior Investigacion
Ct Nac De Investigaciones Onco
Orden Maria Teresa Molina
Sun Honghao
Chamudis Sandra Taliansky
Moya Amancio Carnero
Rodriguez Fernando Blanco
Ocana Maria Victoria Moneo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior Investigacion, Ct Nac De Investigaciones Onco, Orden Maria Teresa Molina, Sun Honghao, Chamudis Sandra Taliansky, Moya Amancio Carnero, Rodriguez Fernando Blanco, Ocana Maria Victoria Moneo filed Critical Consejo Superior Investigacion
Publication of WO2007026041A2 publication Critical patent/WO2007026041A2/es
Publication of WO2007026041A3 publication Critical patent/WO2007026041A3/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/24—Quinones containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C07C205/46—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group the carbon skeleton containing carbon atoms of quinone rings
    • C07C205/47—Anthraquinones containing nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
    • C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
    • C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
    • C07C225/34—Amino anthraquinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/16—Quinones the quinoid structure being part of a condensed ring system containing three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/16—Quinones the quinoid structure being part of a condensed ring system containing three rings
    • C07C50/18—Anthraquinones, i.e. C14H8O2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/16—Quinones the quinoid structure being part of a condensed ring system containing three rings
    • C07C50/20—Quinones the quinoid structure being part of a condensed ring system containing three rings with unsaturation outside the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/34—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Abstract

La presente invención describe unos compuestos derivados 1,4- dioxaantracénicós, principalmente 1, 4-antraquinónicos, de formula I como inhibidores del crecimiento de células tumorales, asi como a procedimientos utiles para su preparación, composiciones farmaceuticas que los contienen y sus aplicaciones clinicas como antitumoral y antiparasitario.
PCT/ES2006/000499 2005-09-02 2006-09-01 Compuestos 1,4 antraquinonicos, su procedimiento de obtencion y su aplicacion como antiumorales. WO2007026041A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP200502145 2005-09-02
ES200502145A ES2268990B1 (es) 2005-09-02 2005-09-02 Compuestos quinonicos antitumorales y sus derivados, procedimiento de obtencion y sus aplicaciones.

Publications (2)

Publication Number Publication Date
WO2007026041A2 WO2007026041A2 (es) 2007-03-08
WO2007026041A3 true WO2007026041A3 (es) 2007-05-03

Family

ID=37809234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2006/000499 WO2007026041A2 (es) 2005-09-02 2006-09-01 Compuestos 1,4 antraquinonicos, su procedimiento de obtencion y su aplicacion como antiumorales.

Country Status (2)

Country Link
ES (1) ES2268990B1 (es)
WO (1) WO2007026041A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113372263B (zh) * 2021-05-21 2022-04-19 温州医科大学 一种2-氯-3-胺基萘醌化合物的制备方法
CN113292503B (zh) * 2021-05-22 2022-05-13 台州市第一人民医院 一种2-溴-3-胺基萘醌化合物的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006107451A2 (en) * 2005-02-23 2006-10-12 Univ Emory Honokiol derivatives for the treatment of proliferative disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006107451A2 (en) * 2005-02-23 2006-10-12 Univ Emory Honokiol derivatives for the treatment of proliferative disorders

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BARRANCO E. ET AL.: "Dynthesis, electrochemical properties and effect of substituents on p-extended TCNQ and DCNQI systems", SYNTHETIC METALS, vol. 56, no. 1, 1993, pages 1717 - 1720, XP003011123 *
BEDWORTH P.V. ET AL.: "The synthesisi of a symmetrically substituted alfa-octa(isopentoxy)anthralocyanine", CHEM. COMMUN., 1997, pages 1353 - 1354, XP003011125 *
DEFOIN A. ET AL.: "Epoxy ketols from monoreduction with hydrides of 2,3-epoxy-1,4-anthraquinone and its meso-diphenyl derivative. Related chlorohydrins", BULLETIN OF THE SOCIETÉ CHIMIQUE DE FRANCE, vol. 3-4, no. 2, 1979, pages 110 - 118 *
HAMZAH A.S. ET AL.: "New Anthraquinones from the Roots of Hedyotis dichotoma", J. NAT PROD., vol. 60, 1997, pages 36 - 37, XP003011126 *
HUA D.H. ET AL.: "Synthesis and in vitro antitumor activity of substituted anthracene-1,4-diones", TETRAHEDRON, vol. 60, no. 45, 2004, pages 10155 - 10163, XP004587536 *
JIMENEZ P. ET AL.: "Thermochemistry of 9-hydroxy-1,4-anthraquinone and 9-methoxy-1,4-anthraquinone", JOURNAL OF CHEMICAL THERMODYNAMICS, vol. 34, no. 7, 2002, pages 1117 - 1126, XP003011124 *
KALLMAYER H.J. ET AL.: "Reaction of 1,4-naphtoquinone and 1,4-anthraquinone with N.N-sialkylhydrazines", PHARMAZIE, vol. 50, no. 7, 1995, pages 506 - 507 *
MARUMO S. ET AL.: "The structure of cervicarcin", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 86, no. 20, 1964, pages 4507 - 4508, XP003011122 *
WANG, YANG ET AL.: "Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor", ANTI-CANCER DRUGS, vol. 16, no. 9, October 2005 (2005-10-01), pages 953 - 967 *

Also Published As

Publication number Publication date
ES2268990A1 (es) 2007-03-16
ES2268990B1 (es) 2008-04-01
WO2007026041A2 (es) 2007-03-08

Similar Documents

Publication Publication Date Title
MX2010003155A (es) Derivados de ciclopropil aril amida y uso de los mismos.
MX2010003156A (es) Derivados de aril amida substituida con tetrazol y usos de los mismos.
WO2004074244A3 (en) Pyrimidine compounds
WO2005070884A3 (en) Heterocyclic compounds useful as growth hormone secretagogues
WO2008079787A8 (en) Glucokinase activators
MY152283A (en) Polo-like kinase inhibitirs
TW200801003A (en) Novel compounds
WO2009146218A3 (en) Compounds including an anti-inflammatory pharmacore and methods of use
MXPA05012025A (es) Imidazo y tiazolopiridinas como inhibidores de cinasa jak3.
HK1113790A1 (en) Selurampanel
TN2011000245A1 (en) Organic compounds
WO2006120208A8 (en) Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
WO2007104034A3 (en) Glucokinase activators
WO2008116107A3 (en) Piperazine derivatives as glucokinase activators
MY148634A (en) Pyridazinone derivatives
IL185611A0 (en) Novel imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same
TW200738659A (en) Novel compounds
MX2009007713A (es) Derivados de piridazina, procedimientos para su preparacion y su uso como fungicidas.
PT1877367E (pt) Derivados do acetileno
TW200714598A (en) Urea derivatives, methods for their manufacture, and uses therefor
DE602004024213D1 (en) Aminopropanolderivate
UA96759C2 (en) 2-ARYLINDOLE DERIVATIVES AS mPGES-I INHIBITORS
WO2007083060A3 (fr) Derives de chalcone a activite antimitotique
WO2009105969A8 (zh) 埃坡霉素类似物、其药物组合物、用途及其制备方法
WO2008104473A3 (en) Pyrazolopyriidine derivatives and their use as kinase inhibitors

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06807941

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 06807941

Country of ref document: EP

Kind code of ref document: A2