WO2006106544A3 - Use of nothobranchius furzeri as a model system for the characterization of drugs that control ageing - Google Patents

Use of nothobranchius furzeri as a model system for the characterization of drugs that control ageing Download PDF

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Publication number
WO2006106544A3
WO2006106544A3 PCT/IT2005/000753 IT2005000753W WO2006106544A3 WO 2006106544 A3 WO2006106544 A3 WO 2006106544A3 IT 2005000753 W IT2005000753 W IT 2005000753W WO 2006106544 A3 WO2006106544 A3 WO 2006106544A3
Authority
WO
WIPO (PCT)
Prior art keywords
characterization
drugs
model system
ageing
control ageing
Prior art date
Application number
PCT/IT2005/000753
Other languages
French (fr)
Other versions
WO2006106544A2 (en
Inventor
Alessandro Cellerino
Original Assignee
Lay Line Genomics Spa
Alessandro Cellerino
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lay Line Genomics Spa, Alessandro Cellerino filed Critical Lay Line Genomics Spa
Priority to EP05823575A priority Critical patent/EP1871427A2/en
Publication of WO2006106544A2 publication Critical patent/WO2006106544A2/en
Publication of WO2006106544A3 publication Critical patent/WO2006106544A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to the use of fish belonging to the family of Cyprinodontids (common name: killifish) as an animal model to study ageing-related diseases. The present invention further relates to a method for the characterization and identification of active substances which can modulate the onset of pathologies related to ageing.
PCT/IT2005/000753 2005-04-07 2005-12-22 Use of nothobranchius furzeri as a model system for the characterization of drugs that control ageing WO2006106544A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05823575A EP1871427A2 (en) 2005-04-07 2005-12-22 Use of nothobranchius furzeri as a model system for the characterization of drugs that control ageing

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2005A000169 2005-04-07
IT000169A ITRM20050169A1 (en) 2005-04-07 2005-04-07 USE OF NOTHOBRANCHIUS FURZERI AS A MODEL SYSTEM FOR THE CHARACTERIZATION OF GENES AND MEDICINES THAT CONTROL AGING.

Publications (2)

Publication Number Publication Date
WO2006106544A2 WO2006106544A2 (en) 2006-10-12
WO2006106544A3 true WO2006106544A3 (en) 2007-05-18

Family

ID=36579492

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/IT2005/000753 WO2006106544A2 (en) 2005-04-07 2005-12-22 Use of nothobranchius furzeri as a model system for the characterization of drugs that control ageing
PCT/IT2006/000238 WO2006106558A2 (en) 2005-04-07 2006-04-07 Use of nothobranchius furzeri as a model system for the characterisation of genes that control ageing

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/IT2006/000238 WO2006106558A2 (en) 2005-04-07 2006-04-07 Use of nothobranchius furzeri as a model system for the characterisation of genes that control ageing

Country Status (3)

Country Link
EP (1) EP1871427A2 (en)
IT (1) ITRM20050169A1 (en)
WO (2) WO2006106544A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001148A1 (en) * 1997-07-02 1999-01-14 Laboratorio Italiano Biochimico Farmaceutico Lisapharma S.P.A. Pharmaceutical composition containing polyphenols from grapes, in particular resveratrol, and yeast extracts
WO1999042606A1 (en) * 1998-02-23 1999-08-26 Phylonix Pharmaceuticals, Inc. Methods of screening agents for activity using teleosts
WO2002013598A2 (en) * 2000-08-17 2002-02-21 U.S. Army Medical Research And Materiel Command Fish hatching method and apparatus
WO2005098428A2 (en) * 2004-04-07 2005-10-20 Marinus Pharmaceuticals, Inc. Method and system for screening compounds for muscular and/or neurological activity in animals

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2416186A1 (en) * 2000-07-31 2002-02-07 Regents Of The University Of Minnesota Inhibition of gene expression using polynucleotide analogues
US6943025B2 (en) * 2001-01-10 2005-09-13 Children's Medical Center Corporation Method for identifying genes involved in cell proliferation
US20020174447A1 (en) * 2001-01-23 2002-11-21 Greenspan Ralph J. Method for functional mapping of an alzheimer's disease gene network and for identifying therapeutic agents for the treatment of alzheimer's disease
US20050155087A1 (en) * 2001-12-17 2005-07-14 Zon Leonard I. Method of screening compounds
EP1546702A2 (en) * 2002-09-11 2005-06-29 Dana-Farber Cancer Institute Transgenic cancer models in fish
GB0301977D0 (en) * 2003-01-28 2003-02-26 Daniolabs Ltd Method for creating a model amenable to high-throughput screening
AU2003901269A0 (en) * 2003-03-19 2003-04-03 Victor Chang Cardiac Research Institute Limited Model for muscular dystrophy
CA2555965A1 (en) * 2004-02-03 2005-08-18 Hybrid Biosciences Pty Ltd Method of identifying genes which promote hybrid vigour and hybrid debility and uses thereof
GB2413847A (en) * 2004-04-26 2005-11-09 Daniolabs Ltd Bone disease models

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001148A1 (en) * 1997-07-02 1999-01-14 Laboratorio Italiano Biochimico Farmaceutico Lisapharma S.P.A. Pharmaceutical composition containing polyphenols from grapes, in particular resveratrol, and yeast extracts
WO1999042606A1 (en) * 1998-02-23 1999-08-26 Phylonix Pharmaceuticals, Inc. Methods of screening agents for activity using teleosts
WO2002013598A2 (en) * 2000-08-17 2002-02-21 U.S. Army Medical Research And Materiel Command Fish hatching method and apparatus
WO2005098428A2 (en) * 2004-04-07 2005-10-20 Marinus Pharmaceuticals, Inc. Method and system for screening compounds for muscular and/or neurological activity in animals

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
GENADE T. ET AL: "Annual fishes of the genus Nothobranchius as a model system for aging research", AGING CELL, vol. 4, July 2005 (2005-07-01), pages 223 - 233, XP008072177, ISSN: 1474-9718 *
JAILLON O. ET AL: "Genome duplication in the teleost fish tetraodon nigroviridis reveals the early vertebrate proto-karyotype", NATURE, vol. 431, October 2004 (2004-10-01), pages 946 - 957, XP008040820 *
KISHI S. ET AL: "The zebrafish as a vertebrate model of functional aging and very gradual senescence", EXPERIMENTAL GERONTOLOGY, vol. 38, 2003, pages 777 - 786, XP008072169, ISSN: 0531-5565 *
KISHI S.: "Functional aging and gradual senescence in zebrafish", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1019, 2004, pages 521 - 526, XP008072168, ISSN: 0077-8923 *
MARZA E. ET AL: "Developmental expression and nutritional regulation of a zebrafish gene homologous to mammalian microsomal triglyceride transfer protein large subunit", DEVELOPMENTAL DYNAMICS, vol. 232, 2005, pages 506 - 518, XP008072212 *
NAKAMUTA M. ET AL: "Mouse microsomal triglyceride transfer protein large subunit: cDNA cloning, tissue-specific expression, and chromosomal localization", GENOMICS, vol. 33, 1996, pages 313 - 316, XP008072210 *
PATNAIK: "Ageing in fishes", GERONTOLOGY, vol. 40, 1994, pages 113 - 132, XP008072174 *
SWAIN H A ET AL: "Effects of dizocilpine (MK-801) on circling behavior, swimming activity, and place preference in zebrafish (Danio rerio)", NEUROTOXICOLOGY AND TERATOLOGY, PERGAMON, ELMSFORD, NY, US, vol. 26, no. 6, November 2004 (2004-11-01), pages 725 - 729, XP004580162, ISSN: 0892-0362 *
TERZIBASI E. ET AL: "The short-lived fish Nothobranchius furzeri as a new model system for aging studies", EXPERIMENTAL GERONTOLOGY, 2006, pages 1 - 9, XP002410022 *
VALDESALICI S. ET AL: "Extremely short lifespan in the annual fish Nothobranchius furzeri", PROC R SOC LOND B, vol. 270, no. Suppl, 2003, pages S189 - S191, XP008072214 *

Also Published As

Publication number Publication date
WO2006106558A3 (en) 2007-03-15
EP1871427A2 (en) 2008-01-02
ITRM20050169A1 (en) 2006-10-08
WO2006106544A2 (en) 2006-10-12
WO2006106558A2 (en) 2006-10-12

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