WO2006095173A3 - Medical uses of 39-desmethoxyrapamycin and analogues thereof - Google Patents

Medical uses of 39-desmethoxyrapamycin and analogues thereof Download PDF

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Publication number
WO2006095173A3
WO2006095173A3 PCT/GB2006/000834 GB2006000834W WO2006095173A3 WO 2006095173 A3 WO2006095173 A3 WO 2006095173A3 GB 2006000834 W GB2006000834 W GB 2006000834W WO 2006095173 A3 WO2006095173 A3 WO 2006095173A3
Authority
WO
WIPO (PCT)
Prior art keywords
desmethoxyrapamycin
analogues
medical uses
medical
relates
Prior art date
Application number
PCT/GB2006/000834
Other languages
French (fr)
Other versions
WO2006095173A2 (en
Inventor
Rose Mary Sheridan
Mingqiang Zhang
Matthew Alan Gregory
Original Assignee
Biotica Tech Ltd
Rose Mary Sheridan
Mingqiang Zhang
Matthew Alan Gregory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0504995.2A external-priority patent/GB0504995D0/en
Priority claimed from GB0522829A external-priority patent/GB0522829D0/en
Priority to NZ561647A priority Critical patent/NZ561647A/en
Priority to EP06710048A priority patent/EP1896018A2/en
Priority to US11/908,367 priority patent/US20100061994A1/en
Priority to MX2007011132A priority patent/MX2007011132A/en
Application filed by Biotica Tech Ltd, Rose Mary Sheridan, Mingqiang Zhang, Matthew Alan Gregory filed Critical Biotica Tech Ltd
Priority to JP2008500265A priority patent/JP2008534442A/en
Priority to AU2006221774A priority patent/AU2006221774A1/en
Priority to BRPI0608726-4A priority patent/BRPI0608726A2/en
Priority to CA002599547A priority patent/CA2599547A1/en
Publication of WO2006095173A2 publication Critical patent/WO2006095173A2/en
Publication of WO2006095173A3 publication Critical patent/WO2006095173A3/en
Priority to IL185548A priority patent/IL185548A0/en
Priority to NO20074661A priority patent/NO20074661L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention relates to medical uses of 39-desmethoxyrapamycin analogues.
PCT/GB2006/000834 2005-03-11 2006-03-10 Medical uses of 39-desmethoxyrapamycin and analogues thereof WO2006095173A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CA002599547A CA2599547A1 (en) 2005-03-11 2006-03-10 Medical uses of 39-desmethoxyrapamycin and analogues thereof
BRPI0608726-4A BRPI0608726A2 (en) 2005-03-11 2006-03-10 use of a 39-demethoxy pyramycin analog or a pharmaceutically acceptable salt thereof, and, pharmaceutical composition
EP06710048A EP1896018A2 (en) 2005-03-11 2006-03-10 Medical uses of 39-desmethoxyrapamycin and analogues thereof
US11/908,367 US20100061994A1 (en) 2005-03-11 2006-03-10 Medical uses of 39-desmethoxyrapamycin and analogues thereof
MX2007011132A MX2007011132A (en) 2005-03-11 2006-03-10 Medical uses of 39-desmethoxyrapamycin and analogues thereof.
NZ561647A NZ561647A (en) 2005-03-11 2006-03-10 Medical uses of 39-desmethoxyrapamycin and analogues thereof
JP2008500265A JP2008534442A (en) 2005-03-11 2006-03-10 Uses of compounds
AU2006221774A AU2006221774A1 (en) 2005-03-11 2006-03-10 Medical uses of 39-desmethoxyrapamycin and analogues thereof
IL185548A IL185548A0 (en) 2005-03-11 2007-08-27 Medical uses of 39-desmethoxyrapamycin and analogues thereof
NO20074661A NO20074661L (en) 2005-03-11 2007-09-13 Use of a compound

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB0504995.2A GB0504995D0 (en) 2005-03-11 2005-03-11 Use of a compound
GB0504995.2 2005-03-11
US11/097,605 US7183289B2 (en) 2005-03-11 2005-04-01 39-desmethoxyrapamycin, compositions and methods of use thereof
US11/097,605 2005-04-01
GB0522829A GB0522829D0 (en) 2005-11-09 2005-11-09 Use of a compound
GB0522829.1 2005-11-09

Publications (2)

Publication Number Publication Date
WO2006095173A2 WO2006095173A2 (en) 2006-09-14
WO2006095173A3 true WO2006095173A3 (en) 2007-01-11

Family

ID=36659697

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/000834 WO2006095173A2 (en) 2005-03-11 2006-03-10 Medical uses of 39-desmethoxyrapamycin and analogues thereof

Country Status (6)

Country Link
EP (1) EP1896018A2 (en)
KR (1) KR20070116868A (en)
AU (1) AU2006221774A1 (en)
CA (1) CA2599547A1 (en)
NO (1) NO20074661L (en)
WO (1) WO2006095173A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0504995D0 (en) * 2005-03-11 2005-04-20 Biotica Tech Ltd Use of a compound
GB0504994D0 (en) 2005-03-11 2005-04-20 Biotica Tech Ltd Novel compounds
WO2017040341A1 (en) * 2015-08-28 2017-03-09 Buck Institute For Research On Aging RAPAMYCIN ANALOGS SHOWING IMPROVED mTORC1 SPECIFICITY
CN111760015A (en) * 2020-01-21 2020-10-13 中南大学 Application of micafungin in preparation of neuroprotective drugs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206018A (en) * 1978-11-03 1993-04-27 Ayerst, Mckenna & Harrison, Inc. Use of rapamycin in treatment of tumors
WO2004007709A2 (en) * 2002-07-16 2004-01-22 Biotica Technology Limited Production of polyketides
WO2006016167A2 (en) * 2004-08-11 2006-02-16 Biotica Technology Limited 17-desmethylrapamycin and analogues thereof, methods for their roduction and their use as immunosupressants, anticancer agents, antifungal agents, etc.

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023262A (en) 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
US5221670A (en) 1990-09-19 1993-06-22 American Home Products Corporation Rapamycin esters
US5138051A (en) 1991-08-07 1992-08-11 American Home Products Corporation Rapamycin analogs as immunosuppressants and antifungals
EP0586512A1 (en) 1991-05-31 1994-03-16 Pfizer Inc. Use of rapamycin prodrugs as immunosuppressant agents
ZA935112B (en) 1992-07-17 1994-02-08 Smithkline Beecham Corp Rapamycin derivatives
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5373014A (en) 1993-10-08 1994-12-13 American Home Products Corporation Rapamycin oximes
US5391730A (en) 1993-10-08 1995-02-21 American Home Products Corporation Phosphorylcarbamates of rapamycin and oxime derivatives thereof
US5378836A (en) 1993-10-08 1995-01-03 American Home Products Corporation Rapamycin oximes and hydrazones
NZ277498A (en) 1993-12-17 1998-03-25 Novartis Ag Rapamycin derivatives
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5563145A (en) 1994-12-07 1996-10-08 American Home Products Corporation Rapamycin 42-oximes and hydroxylamines
CN1124276C (en) 1995-06-09 2003-10-15 诺瓦蒂斯有限公司 Rapamycin derivatives
US5780462A (en) 1995-12-27 1998-07-14 American Home Products Corporation Water soluble rapamycin esters
AU730781B2 (en) 1996-07-30 2001-03-15 Novartis Ag Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin A and 40-0-(2-hydroxiethyl)-rapamycin
US6015815A (en) 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
GB0504994D0 (en) * 2005-03-11 2005-04-20 Biotica Tech Ltd Novel compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206018A (en) * 1978-11-03 1993-04-27 Ayerst, Mckenna & Harrison, Inc. Use of rapamycin in treatment of tumors
WO2004007709A2 (en) * 2002-07-16 2004-01-22 Biotica Technology Limited Production of polyketides
WO2006016167A2 (en) * 2004-08-11 2006-02-16 Biotica Technology Limited 17-desmethylrapamycin and analogues thereof, methods for their roduction and their use as immunosupressants, anticancer agents, antifungal agents, etc.

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GREGORY M A ET AL: "566 Novel mTOR inhibitors with improved pharmacological properties over rapamycin", EUROPEAN JOURNAL OF CANCER. SUPPLEMENT, PERGAMON, OXFORD, GB, vol. 2, no. 8, September 2004 (2004-09-01), pages 172, XP004640010, ISSN: 1359-6349 *
GREGORY MATTHEW A ET AL: "Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis.", ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH) 25 JUL 2005, vol. 44, no. 30, 25 July 2005 (2005-07-25), pages 4757 - 4760, XP009069971, ISSN: 0570-0833 *
HAMILTON G S ET AL: "NEUROIMMUNOPHILIN LIGANDS AS NOVEL THERAPEUTICS FOR THE TREATMENT OF DEGENERATIVE DISORDERS OF THE NERVOUS SYSTEM", CURRENT PHARMACEUTICAL DESIGN, BENTHAM SCIENCE PUBLISHERS, SCHIPHOL, NL, vol. 3, no. 4, 1997, pages 405 - 428, XP000980342, ISSN: 1381-6128 *
LOWDEN PHILIP A S ET AL: "New rapamycin derivatives by precursor-directed biosynthesis.", CHEMBIOCHEM : A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY. 2 APR 2004, vol. 5, no. 4, 2 April 2004 (2004-04-02), pages 535 - 538, XP002391986, ISSN: 1439-4227 *
See also references of EP1896018A2 *

Also Published As

Publication number Publication date
CA2599547A1 (en) 2006-09-14
EP1896018A2 (en) 2008-03-12
WO2006095173A2 (en) 2006-09-14
AU2006221774A1 (en) 2006-09-14
KR20070116868A (en) 2007-12-11
NO20074661L (en) 2007-10-30

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