WO2006083911A3 - Method and apparatus for phase contrast quadrature interferometric detection of an immunoassay - Google Patents
Method and apparatus for phase contrast quadrature interferometric detection of an immunoassay Download PDFInfo
- Publication number
- WO2006083911A3 WO2006083911A3 PCT/US2006/003470 US2006003470W WO2006083911A3 WO 2006083911 A3 WO2006083911 A3 WO 2006083911A3 US 2006003470 W US2006003470 W US 2006003470W WO 2006083911 A3 WO2006083911 A3 WO 2006083911A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- region
- phase contrast
- immunoassay
- target analyte
- quadrature
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
A phase contrast quadrature interferometric method and apparatus for determining the presence or absence of a target analyte in a sample, comprising using a laser beam having a wavelength h and a waist w, to probe at least a portion of a substrate having a reflecting surface that has been exposed to the sample. The reflecting surface includes at least a first region having a layer of recognition molecules specific to the target analyte and a second region that does not include a layer of recognition molecules specific to the target analyte. The method further comprises measuring a time dependent intensity on a photodetector of a substantiall only first quadrature at one of a pair of quadrature angles, of a reflected diffraction signal of the probe beam while probing the first region and the second region.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007553367A JP2008529013A (en) | 2005-02-01 | 2006-02-01 | Method and apparatus for quadrature phase difference interference detection of an immunoassay |
EP06720028A EP1856692A4 (en) | 2005-02-01 | 2006-02-01 | Method and apparatus for phase contrast quadrature interferometric detection of an immunoassay |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64907005P | 2005-02-01 | 2005-02-01 | |
US60/649,070 | 2005-02-01 | ||
US75517705P | 2005-12-30 | 2005-12-30 | |
US60/755,177 | 2005-12-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006083911A2 WO2006083911A2 (en) | 2006-08-10 |
WO2006083911A3 true WO2006083911A3 (en) | 2007-10-11 |
Family
ID=36777851
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/003470 WO2006083911A2 (en) | 2005-02-01 | 2006-02-01 | Method and apparatus for phase contrast quadrature interferometric detection of an immunoassay |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1856692A4 (en) |
JP (1) | JP2008529013A (en) |
WO (1) | WO2006083911A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5361268B2 (en) * | 2008-07-18 | 2013-12-04 | 株式会社ミツトヨ | Oblique incidence interferometer |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4741620A (en) * | 1982-10-08 | 1988-05-03 | National Research Development Corporation | Irradiative probe system |
USRE33581E (en) * | 1984-06-25 | 1991-04-30 | Immunoassay using optical interference detection | |
US5581345A (en) * | 1990-12-03 | 1996-12-03 | Nikon Corporation | Confocal laser scanning mode interference contrast microscope, and method of measuring minute step height and apparatus with said microscope |
US20030026735A1 (en) * | 2001-06-22 | 2003-02-06 | Nolte David D. | Bio-optical compact disk system |
-
2006
- 2006-02-01 WO PCT/US2006/003470 patent/WO2006083911A2/en active Application Filing
- 2006-02-01 EP EP06720028A patent/EP1856692A4/en not_active Withdrawn
- 2006-02-01 JP JP2007553367A patent/JP2008529013A/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4741620A (en) * | 1982-10-08 | 1988-05-03 | National Research Development Corporation | Irradiative probe system |
USRE33581E (en) * | 1984-06-25 | 1991-04-30 | Immunoassay using optical interference detection | |
US5581345A (en) * | 1990-12-03 | 1996-12-03 | Nikon Corporation | Confocal laser scanning mode interference contrast microscope, and method of measuring minute step height and apparatus with said microscope |
US20030026735A1 (en) * | 2001-06-22 | 2003-02-06 | Nolte David D. | Bio-optical compact disk system |
Non-Patent Citations (2)
Title |
---|
See also references of EP1856692A4 * |
VARMA ET AL.: "High-speed label-free detection by spinning-disk mirror-inferometry", BIOSENSORS AND BIOELECTRONICS, vol. 19, 2004, pages 1371 - 1376, XP003016970 * |
Also Published As
Publication number | Publication date |
---|---|
WO2006083911A2 (en) | 2006-08-10 |
EP1856692A2 (en) | 2007-11-21 |
EP1856692A4 (en) | 2009-12-09 |
JP2008529013A (en) | 2008-07-31 |
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