WO2006076025A3 - Immune cell biosensors and methods of using same - Google Patents

Immune cell biosensors and methods of using same Download PDF

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Publication number
WO2006076025A3
WO2006076025A3 PCT/US2005/017136 US2005017136W WO2006076025A3 WO 2006076025 A3 WO2006076025 A3 WO 2006076025A3 US 2005017136 W US2005017136 W US 2005017136W WO 2006076025 A3 WO2006076025 A3 WO 2006076025A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
same
immune cell
cell biosensors
detecting
Prior art date
Application number
PCT/US2005/017136
Other languages
French (fr)
Other versions
WO2006076025A2 (en
WO2006076025A9 (en
Inventor
Milton G Smith
Keith D Crawford
Original Assignee
Amaox Inc
Milton G Smith
Keith D Crawford
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amaox Inc, Milton G Smith, Keith D Crawford filed Critical Amaox Inc
Priority to JP2007513472A priority Critical patent/JP2007536939A/en
Publication of WO2006076025A2 publication Critical patent/WO2006076025A2/en
Publication of WO2006076025A3 publication Critical patent/WO2006076025A3/en
Publication of WO2006076025A9 publication Critical patent/WO2006076025A9/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The present invention relates to immunological cells that are useful in detecting changes in physiological states, which provide for methods of diagnosing diseases or monitoring the course of patient therapy. Also provided are arrays of antigen presenting cell-specific markers for detecting changes in physiological states, and methods of detecting such changes.
PCT/US2005/017136 2004-05-14 2005-05-16 Immune cell biosensors and methods of using same WO2006076025A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007513472A JP2007536939A (en) 2004-05-14 2005-05-16 Immune cell biosensor and method of use thereof

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US57164204P 2004-05-14 2004-05-14
US60/571,642 2004-05-14
US57626004P 2004-06-02 2004-06-02
US60/576,260 2004-06-02
US58654604P 2004-07-09 2004-07-09
US60/586,546 2004-07-09
US61245404P 2004-09-23 2004-09-23
US60/612,454 2004-09-23
US61373304P 2004-09-28 2004-09-28
US60/613,733 2004-09-28
US61492404P 2004-09-29 2004-09-29
US60/614,924 2004-09-29

Publications (3)

Publication Number Publication Date
WO2006076025A2 WO2006076025A2 (en) 2006-07-20
WO2006076025A3 true WO2006076025A3 (en) 2006-12-21
WO2006076025A9 WO2006076025A9 (en) 2007-02-22

Family

ID=36571913

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/017136 WO2006076025A2 (en) 2004-05-14 2005-05-16 Immune cell biosensors and methods of using same

Country Status (2)

Country Link
JP (1) JP2007536939A (en)
WO (1) WO2006076025A2 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040219565A1 (en) 2002-10-21 2004-11-04 Sakari Kauppinen Oligonucleotides useful for detecting and analyzing nucleic acids of interest
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8691510B2 (en) 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
GB2497007B (en) 2008-11-07 2013-08-07 Sequenta Inc Methods of monitoring disease conditions by analysis of the full repertoire of the V-D junction or D-J junction sequences of an individual
WO2010083456A1 (en) 2009-01-15 2010-07-22 Imdaptive Inc. Adaptive immunity profiling and methods for generation of monoclonal antibodies
SG176691A1 (en) 2009-06-25 2012-01-30 Hutchinson Fred Cancer Res Method of measuring adaptive immunity
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
EP2768982A4 (en) 2011-10-21 2015-06-03 Adaptive Biotechnologies Corp Quantification of adaptive immune cell genomes in a complex mixture of cells
AU2012347460B2 (en) 2011-12-09 2017-05-25 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
JP6302847B2 (en) 2012-03-05 2018-03-28 アダプティヴ バイオテクノロジーズ コーポレーション Determination of paired immunoreceptor chains from frequency matched subunits
KR101621643B1 (en) 2012-05-08 2016-05-16 어댑티브 바이오테크놀로지스 코포레이션 Compositions and method for measuring and calibrating amplification bias in multiplexed pcr reactions
JP6449160B2 (en) 2012-10-01 2019-01-09 アダプティブ バイオテクノロジーズ コーポレイション Cross-reference of applications related to immune competence assessment by adaptive immune receptor diversity and clonal characterization
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
EP3114240B1 (en) 2014-03-05 2019-07-24 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
ES2777529T3 (en) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Quantification of adaptive immune cell genomes in a complex mixture of cells
EP3715455A1 (en) 2014-10-29 2020-09-30 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
CA2968543C (en) 2014-11-25 2024-04-02 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
ES2858306T3 (en) 2015-02-24 2021-09-30 Adaptive Biotechnologies Corp Method for determining HLA status by sequencing the immune repertoire
EP3277294B1 (en) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092118A1 (en) * 2001-05-11 2002-11-21 Yale University Global analysis of protein activities using proteome chips
US20040018513A1 (en) * 2002-03-22 2004-01-29 Downing James R Classification and prognosis prediction of acute lymphoblastic leukemia by gene expression profiling
WO2004035819A2 (en) * 2002-10-21 2004-04-29 Exiqon A/S Oligonucleotide analogues for detecting and analyzing nucleic acids
US20040143403A1 (en) * 2002-11-14 2004-07-22 Brandon Richard Bruce Status determination
US20040197930A1 (en) * 2003-03-25 2004-10-07 Ron Rosenfeld Proteomic analysis of biological fluids

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092118A1 (en) * 2001-05-11 2002-11-21 Yale University Global analysis of protein activities using proteome chips
US20040018513A1 (en) * 2002-03-22 2004-01-29 Downing James R Classification and prognosis prediction of acute lymphoblastic leukemia by gene expression profiling
WO2004035819A2 (en) * 2002-10-21 2004-04-29 Exiqon A/S Oligonucleotide analogues for detecting and analyzing nucleic acids
US20040143403A1 (en) * 2002-11-14 2004-07-22 Brandon Richard Bruce Status determination
US20040197930A1 (en) * 2003-03-25 2004-10-07 Ron Rosenfeld Proteomic analysis of biological fluids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ROMERO R ET AL: "PROTEOMIC PROFILING OF PREMATURE LABOR: A METHOD TO IDENTIFY CLINICAL BIOMARKERS AND MECHANISMS OF DISEASE", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 189, no. 6, SUPPL, September 2003 (2003-09-01), pages S63,ABSTRNO20, XP008038129, ISSN: 0002-9378 *

Also Published As

Publication number Publication date
WO2006076025A2 (en) 2006-07-20
JP2007536939A (en) 2007-12-20
WO2006076025A9 (en) 2007-02-22

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