WO2006066950A3 - Tricyclic aminoalcohols, methods for producing the same and their use as anti-inflammatory agents - Google Patents

Tricyclic aminoalcohols, methods for producing the same and their use as anti-inflammatory agents Download PDF

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Publication number
WO2006066950A3
WO2006066950A3 PCT/EP2005/013943 EP2005013943W WO2006066950A3 WO 2006066950 A3 WO2006066950 A3 WO 2006066950A3 EP 2005013943 W EP2005013943 W EP 2005013943W WO 2006066950 A3 WO2006066950 A3 WO 2006066950A3
Authority
WO
WIPO (PCT)
Prior art keywords
aminoalcohols
tricyclic
producing
methods
same
Prior art date
Application number
PCT/EP2005/013943
Other languages
German (de)
French (fr)
Other versions
WO2006066950A2 (en
Inventor
Markus Berger
Norbert Schmees
Heike Schaecke
Stefan Baeurle
Hartmut Rehwinkel
Anne Mengel
Konrad Krolikiewicz
Danja Grossbach
David Voigtlaender
Original Assignee
Schering Ag
Markus Berger
Norbert Schmees
Heike Schaecke
Stefan Baeurle
Hartmut Rehwinkel
Anne Mengel
Konrad Krolikiewicz
Danja Grossbach
David Voigtlaender
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Markus Berger, Norbert Schmees, Heike Schaecke, Stefan Baeurle, Hartmut Rehwinkel, Anne Mengel, Konrad Krolikiewicz, Danja Grossbach, David Voigtlaender filed Critical Schering Ag
Priority to MX2007007420A priority Critical patent/MX2007007420A/en
Priority to BRPI0519710-4A priority patent/BRPI0519710A2/en
Priority to CA002586973A priority patent/CA2586973A1/en
Priority to JP2007547379A priority patent/JP2008524300A/en
Priority to AU2005318354A priority patent/AU2005318354A1/en
Publication of WO2006066950A2 publication Critical patent/WO2006066950A2/en
Publication of WO2006066950A3 publication Critical patent/WO2006066950A3/en
Priority to IL183060A priority patent/IL183060A0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The invention relates to the tricyclic aminoalcohols of general formula (I), to methods for producing the same and to their use as anti-inflammatory agents.
PCT/EP2005/013943 2004-12-22 2005-12-20 Tricyclic aminoalcohols, methods for producing the same and their use as anti-inflammatory agents WO2006066950A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
MX2007007420A MX2007007420A (en) 2004-12-22 2005-12-20 Tricyclic aminoalcohols, methods for producing the same and their use as anti-inflammatory agents.
BRPI0519710-4A BRPI0519710A2 (en) 2004-12-22 2005-12-20 tricyclic amino alcohols, process for their preparation and use as an anti-inflammatory
CA002586973A CA2586973A1 (en) 2004-12-22 2005-12-20 Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs
JP2007547379A JP2008524300A (en) 2004-12-22 2005-12-20 Tricyclic amino alcohols, methods for their synthesis and their use as anti-inflammatory drugs
AU2005318354A AU2005318354A1 (en) 2004-12-22 2005-12-20 Tricyclic aminoalcohols, methods for producing the same and their use as anti-inflammatory agents
IL183060A IL183060A0 (en) 2004-12-22 2007-05-08 Tricyclic aminoalcohols, methods for producing the same and their use as anti-inflammatory agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004063227.8 2004-12-22
DE102004063227A DE102004063227A1 (en) 2004-12-22 2004-12-22 Tricylic amino alcohols, process for their preparation and their use as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
WO2006066950A2 WO2006066950A2 (en) 2006-06-29
WO2006066950A3 true WO2006066950A3 (en) 2006-08-17

Family

ID=36250953

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/013943 WO2006066950A2 (en) 2004-12-22 2005-12-20 Tricyclic aminoalcohols, methods for producing the same and their use as anti-inflammatory agents

Country Status (14)

Country Link
JP (1) JP2008524300A (en)
KR (1) KR20070089948A (en)
CN (1) CN101087780A (en)
AR (1) AR055016A1 (en)
AU (1) AU2005318354A1 (en)
BR (1) BRPI0519710A2 (en)
CA (1) CA2586973A1 (en)
DE (1) DE102004063227A1 (en)
GT (1) GT200500385A (en)
IL (1) IL183060A0 (en)
MX (1) MX2007007420A (en)
PA (1) PA8657801A1 (en)
PE (1) PE20061197A1 (en)
WO (1) WO2006066950A2 (en)

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PL1670458T3 (en) 2003-10-08 2007-05-31 Bayer Schering Pharma Ag 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiphlogistics
US7638515B2 (en) 2003-10-08 2009-12-29 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US7662821B2 (en) 2003-10-08 2010-02-16 Bayer Schering Pharma Ag Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US20080153859A1 (en) 2004-04-05 2008-06-26 Hartmut Rehwinkel Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US7402596B2 (en) 2005-03-24 2008-07-22 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
EP1834948A1 (en) 2006-03-15 2007-09-19 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiinflammatory drugs
TWI464148B (en) 2006-03-16 2014-12-11 Evotec Us Inc Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
EP1917963A1 (en) * 2006-10-31 2008-05-07 Bayer Schering Pharma Aktiengesellschaft Cyclic phenyl-substituted indazols, a process for their production and their use as anti-inflammatory agents
EP2072509A1 (en) 2007-12-18 2009-06-24 Bayer Schering Pharma Aktiengesellschaft 1-Aryl-1H-quinoline-2-ones: process for their production and their use as anti-inflammatory agents
EP2812324B1 (en) 2012-02-08 2021-09-01 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
EP3490607A4 (en) 2016-07-29 2020-04-08 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
CN116514761A (en) 2016-07-29 2023-08-01 赛诺维信制药公司 Compounds, compositions and uses thereof
SG11202000669VA (en) 2017-08-02 2020-02-27 Sunovion Pharmaceuticals Inc Isochroman compounds and uses thereof
KR20210139376A (en) 2019-03-14 2021-11-22 선오비온 파마슈티컬스 인코포레이티드 Salts of isochromanyl compounds, and crystalline forms thereof, methods of preparation, therapeutic uses and pharmaceutical compositions
KR102462991B1 (en) * 2020-11-02 2022-11-04 한국해양과학기술원 Compound from a Antarctic-Derived Fungal Strains Acremonium sp. SF-7394 and Composition for Anti-Inflammation, Anticancer or Anti-Diabetes Comprising the Same

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WO2003082827A1 (en) * 2002-04-02 2003-10-09 Schering Aktiengesellschaft Quinoline and isoquinoline derivatives, method for the production thereof and use thereof as anti-inflammatory agents
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WO2003082280A1 (en) * 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
WO2003082827A1 (en) * 2002-04-02 2003-10-09 Schering Aktiengesellschaft Quinoline and isoquinoline derivatives, method for the production thereof and use thereof as anti-inflammatory agents
WO2005034939A1 (en) * 2003-10-08 2005-04-21 Schering Aktiengesellschaft 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiphlogistics
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Also Published As

Publication number Publication date
PE20061197A1 (en) 2006-12-07
AU2005318354A1 (en) 2006-06-29
KR20070089948A (en) 2007-09-04
DE102004063227A1 (en) 2006-07-06
JP2008524300A (en) 2008-07-10
MX2007007420A (en) 2007-07-17
CA2586973A1 (en) 2006-06-29
IL183060A0 (en) 2007-09-20
CN101087780A (en) 2007-12-12
GT200500385A (en) 2006-08-03
WO2006066950A2 (en) 2006-06-29
PA8657801A1 (en) 2006-12-07
AR055016A1 (en) 2007-08-01
BRPI0519710A2 (en) 2009-03-10

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