WO2006032044A2 - Microfluidic devices - Google Patents
Microfluidic devices Download PDFInfo
- Publication number
- WO2006032044A2 WO2006032044A2 PCT/US2005/033347 US2005033347W WO2006032044A2 WO 2006032044 A2 WO2006032044 A2 WO 2006032044A2 US 2005033347 W US2005033347 W US 2005033347W WO 2006032044 A2 WO2006032044 A2 WO 2006032044A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sample
- microchip
- target analyte
- beads
- nucleic acid
- Prior art date
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
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- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- G01N27/44791—Microapparatus
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- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B01L2300/0627—Sensor or part of a sensor is integrated
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- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/629—Detection means characterised by use of a special device being a microfluidic device
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- Electrochemistry (AREA)
- Pathology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Fluid Mechanics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micromachines (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2005800359117A CN101073002B (en) | 2004-09-15 | 2005-09-15 | Microfluidic devices |
JP2007532553A JP2008513022A (en) | 2004-09-15 | 2005-09-15 | Microfluidic device |
EP05808441A EP1794581A2 (en) | 2004-09-15 | 2005-09-15 | Microfluidic devices |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60997004P | 2004-09-15 | 2004-09-15 | |
US60/609,970 | 2004-09-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006032044A2 true WO2006032044A2 (en) | 2006-03-23 |
WO2006032044A3 WO2006032044A3 (en) | 2007-01-25 |
Family
ID=35541939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/033347 WO2006032044A2 (en) | 2004-09-15 | 2005-09-15 | Microfluidic devices |
Country Status (6)
Country | Link |
---|---|
US (4) | US20070248958A1 (en) |
EP (2) | EP2261650A3 (en) |
JP (2) | JP2008513022A (en) |
KR (1) | KR101214780B1 (en) |
CN (2) | CN102759466A (en) |
WO (1) | WO2006032044A2 (en) |
Cited By (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2434205A (en) * | 2006-01-17 | 2007-07-18 | Siemens Ag | Module for preparing a biological sample, biochip-assembly and use of the module |
JP2008128907A (en) * | 2006-11-22 | 2008-06-05 | Fujifilm Corp | Micro channel chip |
EP1979079A2 (en) * | 2006-02-03 | 2008-10-15 | Microchip Biotechnologies, Inc. | Microfluidic devices |
EP2059584A2 (en) * | 2006-08-24 | 2009-05-20 | Microfluidic Systems Inc. | An integrated airborne substance collection and detection system |
EP2026074A3 (en) * | 2007-07-31 | 2009-07-01 | Samsung Electronics Co., Ltd. | Centrifugal force-based microfluidic device for nucleic acid detection and microfluidic system including the same |
WO2009108260A2 (en) | 2008-01-22 | 2009-09-03 | Microchip Biotechnologies, Inc. | Universal sample preparation system and use in an integrated analysis system |
WO2009136232A1 (en) * | 2008-05-05 | 2009-11-12 | Korkut Celal Vata | Automated, high band resolution electrophoretic system for digital visualization and method of use |
WO2010091400A3 (en) * | 2009-02-09 | 2010-10-14 | Frederic Zenhausern | Improvements in and relating to microfluidic devices for processing a sample |
EP2276570A1 (en) * | 2008-04-10 | 2011-01-26 | Valtion Teknillinen Tutkimuskeskus | Microfluidic chip devices and their use |
EP2388500A1 (en) * | 2010-05-18 | 2011-11-23 | Samsung Electronics Co., Ltd. | Microvalve device and method of manufacturing the same |
WO2011112746A3 (en) * | 2010-03-09 | 2012-01-12 | Netbio, Inc. | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
US8388908B2 (en) | 2009-06-02 | 2013-03-05 | Integenx Inc. | Fluidic devices with diaphragm valves |
EP2567211A2 (en) * | 2010-05-05 | 2013-03-13 | Beckman Coulter Biomedical, LLC | Diagnostic system and components |
US8425861B2 (en) | 2007-04-04 | 2013-04-23 | Netbio, Inc. | Methods for rapid multiplexed amplification of target nucleic acids |
US8431390B2 (en) | 2004-09-15 | 2013-04-30 | Integenx Inc. | Systems of sample processing having a macro-micro interface |
EP2604343A1 (en) * | 2011-12-15 | 2013-06-19 | Samsung Electronics Co., Ltd | Microfluidic device and method of manufacturing the same |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
KR101306341B1 (en) * | 2006-09-05 | 2013-09-09 | 삼성전자주식회사 | Centrifugal force-based microfluidic device for nucleic acid extraction from biological sample and microfluidic system comprising the microfluidic system |
KR101307859B1 (en) | 2007-07-19 | 2013-09-12 | 삼성전자주식회사 | Bio-chemical analyzer and method for controlling inside temperatures thereof |
CN103331186A (en) * | 2009-07-07 | 2013-10-02 | 索尼公司 | Microfluidic device |
US8557518B2 (en) | 2007-02-05 | 2013-10-15 | Integenx Inc. | Microfluidic and nanofluidic devices, systems, and applications |
US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
US8585916B2 (en) | 2008-01-24 | 2013-11-19 | Sandia Corporation | Micropores and methods of making and using thereof |
CN103627806A (en) * | 2013-12-03 | 2014-03-12 | 武汉大学 | Method for developing SSR marks based on magnetic field controllable micro-fluidic chip |
US8672532B2 (en) | 2008-12-31 | 2014-03-18 | Integenx Inc. | Microfluidic methods |
US8720036B2 (en) | 2010-03-09 | 2014-05-13 | Netbio, Inc. | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
US8763642B2 (en) | 2010-08-20 | 2014-07-01 | Integenx Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
US8841116B2 (en) * | 2006-10-25 | 2014-09-23 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated DNA analysis system using same |
US9040288B2 (en) | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US9057046B2 (en) | 2005-09-26 | 2015-06-16 | Rapid Micro Biosystems, Inc. | Cassette containing growth medium |
US9080207B2 (en) | 2006-03-24 | 2015-07-14 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US9090462B2 (en) | 2001-09-06 | 2015-07-28 | Rapid Micro Biosystems, Inc. | Rapid detection of replicating cells |
US9121058B2 (en) | 2010-08-20 | 2015-09-01 | Integenx Inc. | Linear valve arrays |
WO2015128259A1 (en) * | 2014-02-28 | 2015-09-03 | Ge Healthcare Uk Limited | Improvements in and relating to processed biological sample storage |
US9267618B2 (en) | 2010-05-18 | 2016-02-23 | Samsung Electronics Co., Ltd. | Microvalve device and method of manufacturing the same |
US9550985B2 (en) | 2009-06-15 | 2017-01-24 | Netbio, Inc. | Methods for forensic DNA quantitation |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
US9644623B2 (en) | 2002-12-30 | 2017-05-09 | The Regents Of The University Of California | Fluid control structures in microfluidic devices |
US9643180B2 (en) | 2008-09-24 | 2017-05-09 | First Light Biosciences, Inc. | Method for detecting analytes |
US9670528B2 (en) | 2003-07-31 | 2017-06-06 | Handylab, Inc. | Processing particle-containing samples |
US9677121B2 (en) | 2001-03-28 | 2017-06-13 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US9745546B2 (en) | 2011-11-07 | 2017-08-29 | Rapid Micro Biosystems, Inc. | Cassette for sterility testing |
US9765389B2 (en) | 2011-04-15 | 2017-09-19 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US9802199B2 (en) | 2006-03-24 | 2017-10-31 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US9815057B2 (en) | 2006-11-14 | 2017-11-14 | Handylab, Inc. | Microfluidic cartridge and method of making same |
US9994839B2 (en) | 2013-01-16 | 2018-06-12 | The Regents Of The University Of California | Microfluidic devices to extract, concentrate and isolate molecules |
US10001496B2 (en) | 2007-01-29 | 2018-06-19 | Gearbox, Llc | Systems for allergen detection |
US10065185B2 (en) | 2007-07-13 | 2018-09-04 | Handylab, Inc. | Microfluidic cartridge |
US10071376B2 (en) | 2007-07-13 | 2018-09-11 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10076754B2 (en) | 2011-09-30 | 2018-09-18 | Becton, Dickinson And Company | Unitized reagent strip |
USD831843S1 (en) | 2011-09-30 | 2018-10-23 | Becton, Dickinson And Company | Single piece reagent holder |
US10179910B2 (en) | 2007-07-13 | 2019-01-15 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US10210410B2 (en) | 2014-10-22 | 2019-02-19 | Integenx Inc. | Systems and methods for biometric data collections |
US10213783B2 (en) | 2015-07-17 | 2019-02-26 | Delta Electronics, Inc. | Nucleic acid extracting device |
US10234474B2 (en) | 2007-07-13 | 2019-03-19 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US10296720B2 (en) | 2005-11-30 | 2019-05-21 | Gearbox Llc | Computational systems and methods related to nutraceuticals |
US10364456B2 (en) | 2004-05-03 | 2019-07-30 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US10407707B2 (en) | 2012-04-16 | 2019-09-10 | Rapid Micro Biosystems, Inc. | Cell culturing device |
US10571935B2 (en) | 2001-03-28 | 2020-02-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US10590410B2 (en) | 2007-07-13 | 2020-03-17 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US10648975B2 (en) | 2017-07-03 | 2020-05-12 | Lansion Biotechnology Co., Ltd. | Single channel chemiluminescent micro-fluidic chip and detection method thereof |
US10822644B2 (en) | 2012-02-03 | 2020-11-03 | Becton, Dickinson And Company | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US10961561B2 (en) | 2014-05-21 | 2021-03-30 | IntegenX, Inc. | Fluidic cartridge with valve mechanism |
EP3842134A1 (en) * | 2019-12-10 | 2021-06-30 | Industrial Technology Research Institute | Nucleic acid extracting device |
US20210276012A1 (en) * | 2018-07-10 | 2021-09-09 | Tdk Corporation | Device and method for detecting nucleic acids by isothermal amplification technique |
US11207681B2 (en) | 2015-07-17 | 2021-12-28 | Delta Electronics, Inc. | Method for extracting nucleic acid and extraction cassette thereof |
WO2022029299A3 (en) * | 2020-08-06 | 2022-04-07 | Thermo Fisher Scientific Geneart Gmbh | Laboratory equipment, corresponding uses and methods |
US11453906B2 (en) | 2011-11-04 | 2022-09-27 | Handylab, Inc. | Multiplexed diagnostic detection apparatus and methods |
US11491482B2 (en) | 2015-07-17 | 2022-11-08 | Delta Electronics, Inc. | Method for extracting nucleic acid and extraction cassette thereof |
US11733258B2 (en) | 2019-12-10 | 2023-08-22 | Industrial Technology Research Institute | Nucleic acid extracting device |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
Families Citing this family (203)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2290731A1 (en) | 1999-11-26 | 2001-05-26 | D. Jed Harrison | Apparatus and method for trapping bead based reagents within microfluidic analysis system |
US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US20030108664A1 (en) * | 2001-10-05 | 2003-06-12 | Kodas Toivo T. | Methods and compositions for the formation of recessed electrical features on a substrate |
US20030217923A1 (en) * | 2002-05-24 | 2003-11-27 | Harrison D. Jed | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
GB0508531D0 (en) | 2005-04-27 | 2005-06-01 | Smith & Nephew | Sai with ultrasound |
US7799553B2 (en) * | 2004-06-01 | 2010-09-21 | The Regents Of The University Of California | Microfabricated integrated DNA analysis system |
US8053214B2 (en) * | 2004-09-09 | 2011-11-08 | Microfluidic Systems, Inc. | Apparatus and method of extracting and optically analyzing an analyte from a fluid-based sample |
WO2006029387A1 (en) * | 2004-09-09 | 2006-03-16 | Microfluidic Systems Inc. | A handheld and portable microfluidic device to automatically prepare nucleic acids for analysis |
GB0421529D0 (en) | 2004-09-28 | 2004-10-27 | Landegren Gene Technology Ab | Microfluidic structure |
US7635594B2 (en) | 2005-05-09 | 2009-12-22 | Theranos, Inc. | Point-of-care fluidic systems and uses thereof |
US7727473B2 (en) | 2005-10-19 | 2010-06-01 | Progentech Limited | Cassette for sample preparation |
US7754148B2 (en) | 2006-12-27 | 2010-07-13 | Progentech Limited | Instrument for cassette for sample preparation |
FR2896315B1 (en) * | 2005-11-08 | 2010-09-17 | Cit Alcatel | AMPLIFIER OPTICAL FIBER |
US7827042B2 (en) | 2005-11-30 | 2010-11-02 | The Invention Science Fund I, Inc | Methods and systems related to transmission of nutraceutical associated information |
US8068991B2 (en) | 2005-11-30 | 2011-11-29 | The Invention Science Fund I, Llc | Systems and methods for transmitting pathogen related information and responding |
US7974856B2 (en) | 2005-11-30 | 2011-07-05 | The Invention Science Fund I, Llc | Computational systems and methods related to nutraceuticals |
US8340944B2 (en) | 2005-11-30 | 2012-12-25 | The Invention Science Fund I, Llc | Computational and/or control systems and methods related to nutraceutical agent selection and dosing |
US7927787B2 (en) | 2006-06-28 | 2011-04-19 | The Invention Science Fund I, Llc | Methods and systems for analysis of nutraceutical associated components |
US8000981B2 (en) | 2005-11-30 | 2011-08-16 | The Invention Science Fund I, Llc | Methods and systems related to receiving nutraceutical associated information |
US8297028B2 (en) | 2006-06-14 | 2012-10-30 | The Invention Science Fund I, Llc | Individualized pharmaceutical selection and packaging |
US7749365B2 (en) | 2006-02-01 | 2010-07-06 | IntegenX, Inc. | Optimized sample injection structures in microfluidic separations |
US7766033B2 (en) | 2006-03-22 | 2010-08-03 | The Regents Of The University Of California | Multiplexed latching valves for microfluidic devices and processors |
US8617903B2 (en) | 2007-01-29 | 2013-12-31 | The Invention Science Fund I, Llc | Methods for allergen detection |
US8153064B2 (en) | 2007-03-22 | 2012-04-10 | Doebler Ii Robert W | Systems and devices for isothermal biochemical reactions and/or analysis |
FR2917095B1 (en) * | 2007-06-07 | 2009-07-17 | Biomerieux Sa | DEVICE FOR LYING MICROORGANISMS PRESENT IN AN ENVIRONMENTAL OR CLINICAL SAMPLE AND EXTRACTING NUCLEIC ACIDS FROM SAID MICROORGANISMS FOR ANALYSIS. |
KR100970481B1 (en) * | 2008-11-06 | 2010-07-16 | 삼성전자주식회사 | Microfluidic structure and method for producing same |
CN101970111B (en) | 2007-06-21 | 2013-09-11 | 简·探针公司 | Instrument and receptacles for performing processes |
US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
WO2009015296A1 (en) | 2007-07-24 | 2009-01-29 | The Regents Of The University Of California | Microfabricated dropley generator |
KR101335727B1 (en) * | 2007-08-22 | 2013-12-04 | 삼성전자주식회사 | Centrifugal force-based disk type microfluidic device for blood chemistry analysis |
CA2934220C (en) | 2007-10-02 | 2019-11-05 | Theranos, Inc. | Modular point-of-care devices and uses thereof |
KR101465961B1 (en) * | 2007-10-09 | 2014-12-01 | 삼성전자주식회사 | A method and a device for detecting DNAs, etc. |
JP5523327B2 (en) | 2007-10-12 | 2014-06-18 | レオニックス,インコーポレイテッド | Integrated microfluidic device and method |
US20090176312A1 (en) * | 2007-12-04 | 2009-07-09 | Selinfreund Richard H | Biological and chemical test media and system |
WO2009089466A2 (en) | 2008-01-09 | 2009-07-16 | Keck Graduate Institute | System, apparatus and method for material preparation and/or handling |
EP2087934A1 (en) * | 2008-02-07 | 2009-08-12 | Qiagen GmbH | Method and device for processing a sample automatically |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
US8871441B2 (en) * | 2008-08-21 | 2014-10-28 | Novozymes A/S | Microfluidic device screening method |
WO2010025302A2 (en) * | 2008-08-27 | 2010-03-04 | Life Technologies Corporation | Apparatus for and method of processing biological samples |
US8133451B2 (en) * | 2008-08-28 | 2012-03-13 | Microfluidic Systems, Inc. | Sample preparation apparatus |
US8962258B2 (en) * | 2008-08-29 | 2015-02-24 | Korea Advanced Institute Of Science And Technology | Apparatus and method for multiple immunoassays on a chip |
US9000353B2 (en) | 2010-06-22 | 2015-04-07 | President And Fellows Of Harvard College | Light absorption and filtering properties of vertically oriented semiconductor nano wires |
US9406709B2 (en) | 2010-06-22 | 2016-08-02 | President And Fellows Of Harvard College | Methods for fabricating and using nanowires |
US8384007B2 (en) | 2009-10-07 | 2013-02-26 | Zena Technologies, Inc. | Nano wire based passive pixel image sensor |
US8269985B2 (en) | 2009-05-26 | 2012-09-18 | Zena Technologies, Inc. | Determination of optimal diameters for nanowires |
US8735797B2 (en) | 2009-12-08 | 2014-05-27 | Zena Technologies, Inc. | Nanowire photo-detector grown on a back-side illuminated image sensor |
US8274039B2 (en) | 2008-11-13 | 2012-09-25 | Zena Technologies, Inc. | Vertical waveguides with various functionality on integrated circuits |
US8299472B2 (en) | 2009-12-08 | 2012-10-30 | Young-June Yu | Active pixel sensor with nanowire structured photodetectors |
US8835831B2 (en) | 2010-06-22 | 2014-09-16 | Zena Technologies, Inc. | Polarized light detecting device and fabrication methods of the same |
US8546742B2 (en) | 2009-06-04 | 2013-10-01 | Zena Technologies, Inc. | Array of nanowires in a single cavity with anti-reflective coating on substrate |
US9478685B2 (en) | 2014-06-23 | 2016-10-25 | Zena Technologies, Inc. | Vertical pillar structured infrared detector and fabrication method for the same |
US8507840B2 (en) | 2010-12-21 | 2013-08-13 | Zena Technologies, Inc. | Vertically structured passive pixel arrays and methods for fabricating the same |
US8889455B2 (en) | 2009-12-08 | 2014-11-18 | Zena Technologies, Inc. | Manufacturing nanowire photo-detector grown on a back-side illuminated image sensor |
US8866065B2 (en) | 2010-12-13 | 2014-10-21 | Zena Technologies, Inc. | Nanowire arrays comprising fluorescent nanowires |
US9515218B2 (en) | 2008-09-04 | 2016-12-06 | Zena Technologies, Inc. | Vertical pillar structured photovoltaic devices with mirrors and optical claddings |
US9082673B2 (en) | 2009-10-05 | 2015-07-14 | Zena Technologies, Inc. | Passivated upstanding nanostructures and methods of making the same |
US8890271B2 (en) | 2010-06-30 | 2014-11-18 | Zena Technologies, Inc. | Silicon nitride light pipes for image sensors |
US8791470B2 (en) | 2009-10-05 | 2014-07-29 | Zena Technologies, Inc. | Nano structured LEDs |
US9343490B2 (en) | 2013-08-09 | 2016-05-17 | Zena Technologies, Inc. | Nanowire structured color filter arrays and fabrication method of the same |
US8229255B2 (en) | 2008-09-04 | 2012-07-24 | Zena Technologies, Inc. | Optical waveguides in image sensors |
US9299866B2 (en) | 2010-12-30 | 2016-03-29 | Zena Technologies, Inc. | Nanowire array based solar energy harvesting device |
US8748799B2 (en) | 2010-12-14 | 2014-06-10 | Zena Technologies, Inc. | Full color single pixel including doublet or quadruplet si nanowires for image sensors |
US8519379B2 (en) | 2009-12-08 | 2013-08-27 | Zena Technologies, Inc. | Nanowire structured photodiode with a surrounding epitaxially grown P or N layer |
US20100112588A1 (en) * | 2008-11-04 | 2010-05-06 | Caerus Molecular Diagnostics, Inc. | Methods for sanger sequencing using particle associated clonal amplicons and highly parallel electrophoretic size-based separation |
WO2010074265A1 (en) | 2008-12-25 | 2010-07-01 | ユニバーサル・バイオ・リサーチ株式会社 | Method for pretreating specimen and method for assaying biological substance |
EP2394152B1 (en) | 2009-02-03 | 2019-05-01 | ANDE Corporation | Nucleic acid purification |
EP2421651A4 (en) * | 2009-04-21 | 2013-06-12 | Advandx Inc | Multiplex analysis of cells, particles, and other analytes |
US20110130560A1 (en) * | 2009-05-29 | 2011-06-02 | Bio-Rad Laboratories, Inc. | Sonication cartridge for nucleic acid extraction |
AU2010257118B2 (en) | 2009-06-04 | 2014-08-28 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for DNA analysis |
KR20120031218A (en) | 2009-06-05 | 2012-03-30 | 인터젠엑스 인크. | Universal sample preparation system and use in an integrated analysis system |
US9260475B2 (en) * | 2009-06-26 | 2016-02-16 | Claremont Biosolutions Llc | Capture and elution of bio-analytes via beads that are used to disrupt specimens |
JP2011030522A (en) * | 2009-08-04 | 2011-02-17 | Aida Engineering Ltd | Microfluid device |
US20110091873A1 (en) * | 2009-10-21 | 2011-04-21 | Microfluidic Systems, Inc. | Integrated sample preparation and amplification for nucleic acid detection from biological samples |
US20110143378A1 (en) * | 2009-11-12 | 2011-06-16 | CyVek LLC. | Microfluidic method and apparatus for high performance biological assays |
US9759718B2 (en) * | 2009-11-23 | 2017-09-12 | Cyvek, Inc. | PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use |
US10065403B2 (en) | 2009-11-23 | 2018-09-04 | Cyvek, Inc. | Microfluidic assay assemblies and methods of manufacture |
US9500645B2 (en) | 2009-11-23 | 2016-11-22 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
US9700889B2 (en) | 2009-11-23 | 2017-07-11 | Cyvek, Inc. | Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results |
US9651568B2 (en) | 2009-11-23 | 2017-05-16 | Cyvek, Inc. | Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays |
US9855735B2 (en) | 2009-11-23 | 2018-01-02 | Cyvek, Inc. | Portable microfluidic assay devices and methods of manufacture and use |
CN102713621B (en) | 2009-11-23 | 2016-10-19 | 西维克公司 | For the method and apparatus implementing chemical examination |
US9321051B2 (en) * | 2009-12-22 | 2016-04-26 | Samsung Electronics Co., Ltd. | Microfluidic device and method of manufacturing the same |
BR112012021202B1 (en) | 2010-02-23 | 2020-06-09 | Genturadx Usa Inc | apparatus and methods for integrated sample preparation, reaction and detection |
US20110262989A1 (en) | 2010-04-21 | 2011-10-27 | Nanomr, Inc. | Isolating a target analyte from a body fluid |
US8841104B2 (en) | 2010-04-21 | 2014-09-23 | Nanomr, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
US9476812B2 (en) | 2010-04-21 | 2016-10-25 | Dna Electronics, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
US9568428B2 (en) | 2010-05-05 | 2017-02-14 | Beckman Coulter Biomedical, Llc | Diagnostic instrument and flow process |
US8648760B2 (en) * | 2010-06-22 | 2014-02-11 | Harris Corporation | Continuous dipole antenna |
US8798950B2 (en) | 2010-08-20 | 2014-08-05 | Bio-Rad Laboratories, Inc. | System and method for ultrasonic transducer control |
CA2814720C (en) | 2010-10-15 | 2016-12-13 | Lockheed Martin Corporation | Micro fluidic optic design |
US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
US8941062B2 (en) * | 2010-11-16 | 2015-01-27 | 1087 Systems, Inc. | System for identifying and sorting living cells |
US20120225475A1 (en) | 2010-11-16 | 2012-09-06 | 1087 Systems, Inc. | Cytometry system with quantum cascade laser source, acoustic detector, and micro-fluidic cell handling system configured for inspection of individual cells |
US8663974B2 (en) | 2010-12-23 | 2014-03-04 | Claremont Biosolutions Llc | Compositions and methods for capture and elution of biological materials via particulates |
AU2012220825B2 (en) * | 2011-02-21 | 2015-12-17 | Rheonix, Inc. | Microfluidic device-based nucleic acid purification method |
US8718948B2 (en) | 2011-02-24 | 2014-05-06 | Gen-Probe Incorporated | Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector |
CN106552682B (en) | 2011-03-22 | 2020-06-19 | 西维克公司 | Microfluidic device and methods of manufacture and use |
CN104023834B (en) | 2011-05-04 | 2016-09-28 | 卢米耐克斯公司 | The apparatus and method for prepared for integrated sample, react and detect |
CN106995780B (en) * | 2011-05-05 | 2019-11-22 | 安派科生物医学科技有限公司 | Tumour cell detector |
WO2013019714A1 (en) | 2011-07-29 | 2013-02-07 | The Trustees Of Columbia University In The City Of New York | Mems affinity sensor for continuous monitoring of analytes |
CN102360010B (en) * | 2011-08-05 | 2014-01-01 | 上海交通大学 | Integrated microfluidic chip for capture of cancer cells in whole blood |
US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
US8894946B2 (en) | 2011-10-21 | 2014-11-25 | Integenx Inc. | Sample preparation, processing and analysis systems |
US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
WO2013096528A1 (en) * | 2011-12-20 | 2013-06-27 | Siemens Healthcare Diagnostics Inc. | Coated substrates for high energy capture phase binding and methods of production and use thereof |
WO2013112877A1 (en) | 2012-01-25 | 2013-08-01 | Tasso, Inc. | Handheld device for drawing, collecting, and analyzing bodily fluid |
US9289763B2 (en) | 2012-07-23 | 2016-03-22 | Tasso, Inc. | Methods, systems, and devices relating to open microfluidic channels |
US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
EP2822689B1 (en) | 2012-03-08 | 2023-07-26 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
CN102784672A (en) * | 2012-08-13 | 2012-11-21 | 苏州汶颢芯片科技有限公司 | Centrifugal micro-fluidic chip for detecting nitrate and nitrite and preparation method of centrifugal micro-fluidic chip |
CN102784671A (en) * | 2012-08-13 | 2012-11-21 | 苏州汶颢芯片科技有限公司 | Centrifugal micro-fluidic chip for detecting pesticide residue and preparation method thereof |
CN102784674A (en) * | 2012-08-13 | 2012-11-21 | 苏州汶颢芯片科技有限公司 | Centrifugal micro-fluidic chip for detecting chromium ion form in water body and preparation method of centrifugal micro-fluidic chip |
CN104583386A (en) * | 2012-08-20 | 2015-04-29 | 泰尔茂比司特公司 | Concentrating components of fluid circulated through cell growth chamber |
GB201217344D0 (en) * | 2012-09-28 | 2012-11-14 | Ibm | Microfluidic surface processing systems with self- regulated distance-to surface control |
EP3427830B1 (en) | 2012-10-24 | 2021-06-23 | Genmark Diagnostics Inc. | Integrated multiplex target analysis |
EP2927671A4 (en) * | 2012-11-30 | 2015-11-11 | Panasonic Ip Man Co Ltd | Sample-holding carrier and fluorescence detection device using same |
US9599610B2 (en) | 2012-12-19 | 2017-03-21 | Dnae Group Holdings Limited | Target capture system |
US9804069B2 (en) | 2012-12-19 | 2017-10-31 | Dnae Group Holdings Limited | Methods for degrading nucleic acid |
EP2935613B1 (en) * | 2012-12-19 | 2020-05-27 | DNAE Group Holdings Limited | Target capture system |
US9551704B2 (en) | 2012-12-19 | 2017-01-24 | Dna Electronics, Inc. | Target detection |
US10000557B2 (en) | 2012-12-19 | 2018-06-19 | Dnae Group Holdings Limited | Methods for raising antibodies |
US9995742B2 (en) | 2012-12-19 | 2018-06-12 | Dnae Group Holdings Limited | Sample entry |
US9434940B2 (en) | 2012-12-19 | 2016-09-06 | Dna Electronics, Inc. | Methods for universal target capture |
WO2014100686A1 (en) * | 2012-12-20 | 2014-06-26 | University Of Notre Dame Du Lac | Non-aqueous microchip electrophoresis for characterization of lipid biomarkers |
IL297030B2 (en) | 2013-03-11 | 2024-03-01 | Cue Health Inc | A method of actuating fluid flow within a microfluidic cartridge |
US10545161B2 (en) | 2013-03-11 | 2020-01-28 | Cue Health Inc. | Systems and methods for detection and quantification of analytes |
US9623409B2 (en) | 2013-03-11 | 2017-04-18 | Cue Inc. | Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes |
US9222623B2 (en) | 2013-03-15 | 2015-12-29 | Genmark Diagnostics, Inc. | Devices and methods for manipulating deformable fluid vessels |
MX368673B (en) | 2013-03-15 | 2019-10-10 | Theranos Ip Co Llc | Devices, systems and methods for sample preparation. |
US9359632B2 (en) | 2013-03-15 | 2016-06-07 | Theranos, Inc. | Devices, systems and methods for sample preparation |
SE537452C2 (en) * | 2013-04-02 | 2015-05-05 | Btg Instr Ab | Sampling and analysis device |
US8961904B2 (en) | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
WO2015045666A1 (en) * | 2013-09-25 | 2015-04-02 | 国立大学法人東京大学 | Fluid device, exosome analysis method, biomolecule analysis method, and biomolecule detection method |
US9498778B2 (en) * | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
WO2015073999A1 (en) | 2013-11-18 | 2015-05-21 | Integenx Inc. | Cartridges and instruments for sample analysis |
GB201401584D0 (en) * | 2014-01-29 | 2014-03-19 | Bg Res Ltd | Intelligent detection of biological entities |
US20170022546A1 (en) * | 2014-03-10 | 2017-01-26 | Rashid Bashir | Detection and quantification of methylation in dna |
DE102014205728B3 (en) * | 2014-03-27 | 2015-03-05 | Robert Bosch Gmbh | A chip laboratory cartridge for a microfluidic system for analyzing a sample of biological material, a microfluidic system for analyzing a sample of biological material, and a method and apparatus for analyzing a sample of biological material |
EP3132073B1 (en) * | 2014-04-14 | 2021-06-30 | SRI International | Portable nucleic acid analysis system and high-performance microfluidic electroactive polymer actuators |
USD745423S1 (en) | 2014-05-12 | 2015-12-15 | Cue Inc. | Automated analyzer test cartridge and sample collection device for analyte detection |
EP3145625B1 (en) * | 2014-05-21 | 2023-07-05 | Unchained Labs | Systems and methods for exchange of buffer solutions |
WO2016019388A1 (en) | 2014-08-01 | 2016-02-04 | Tasso, Inc. | Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids |
WO2016022696A1 (en) | 2014-08-05 | 2016-02-11 | The Trustees Of Columbia University In The City Of New York | Method of isolating aptamers for minimal residual disease detection |
US10196678B2 (en) | 2014-10-06 | 2019-02-05 | ALVEO Technologies Inc. | System and method for detection of nucleic acids |
US10627358B2 (en) | 2014-10-06 | 2020-04-21 | Alveo Technologies, Inc. | Method for detection of analytes |
US9506908B2 (en) | 2014-10-06 | 2016-11-29 | Alveo Technologies, Inc. | System for detection of analytes |
US9921182B2 (en) | 2014-10-06 | 2018-03-20 | ALVEO Technologies Inc. | System and method for detection of mercury |
US10352899B2 (en) | 2014-10-06 | 2019-07-16 | ALVEO Technologies Inc. | System and method for detection of silver |
EP3209410A4 (en) | 2014-10-22 | 2018-05-02 | IntegenX Inc. | Systems and methods for sample preparation, processing and analysis |
CA2968851A1 (en) | 2014-11-25 | 2016-06-02 | Quest Diagnostics Investments Incorporated | Amplification and detection of nucleic acids in a biological sample |
DE102015202667A1 (en) * | 2015-02-13 | 2016-08-18 | Postnova Analytics Gmbh | Device for field flow fractionation |
JP2018509615A (en) | 2015-02-19 | 2018-04-05 | プレミアム ジェネティクス (ユーケー) リミテッド | Scanning infrared measurement system |
EP3072595A1 (en) * | 2015-03-24 | 2016-09-28 | European Molecular Biology Laboratory | Microfluidic sorting device |
US9632066B2 (en) | 2015-04-09 | 2017-04-25 | Ut-Battelle, Llc | Open port sampling interface |
US10060838B2 (en) * | 2015-04-09 | 2018-08-28 | Ut-Battelle, Llc | Capture probe |
US11164661B2 (en) | 2015-04-10 | 2021-11-02 | University Of Washington | Integrated system for nucleic acid-based storage and retrieval of digital data using keys |
EP3307885B1 (en) | 2015-06-15 | 2020-10-21 | Cepheid | Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge |
US10233491B2 (en) | 2015-06-19 | 2019-03-19 | IntegenX, Inc. | Valved cartridge and system |
CN117310193A (en) | 2015-07-17 | 2023-12-29 | 克忧健康公司 | Systems and methods for enhanced detection and analyte quantification |
US10228367B2 (en) | 2015-12-01 | 2019-03-12 | ProteinSimple | Segmented multi-use automated assay cartridge |
CN109068979B (en) | 2015-12-21 | 2021-08-20 | 塔索公司 | Devices, systems, and methods for actuation and retraction in fluid collection |
SG10201911933TA (en) * | 2016-01-05 | 2020-02-27 | Nippon Sheet Glass Company Limited | Reaction treatment device, reaction treatment container, and reaction treatment method |
JP6614328B2 (en) * | 2016-02-22 | 2019-12-04 | 日本電気株式会社 | Microchip |
EP3436193A1 (en) * | 2016-03-28 | 2019-02-06 | Nanoimmunotech, S.L. | Microfluidics for analyte detection based on the light to heat conversion properties of metal nanoparticles |
CN109477801B (en) | 2016-07-01 | 2021-08-20 | 哈希朗格有限公司 | Microfluidic process water analyzer |
CN106198363B (en) * | 2016-09-13 | 2020-08-07 | 江苏卓微生物科技有限公司 | Flow cytometry detection chip |
KR102461735B1 (en) | 2016-09-23 | 2022-11-01 | 알베오 테크놀로지스 인크. | Methods and compositions for detecting analytes |
WO2018057996A1 (en) * | 2016-09-23 | 2018-03-29 | ArcherDX, Inc. | Fluidic system and related methods |
US10514117B2 (en) * | 2016-10-05 | 2019-12-24 | Waters Technologies Corporation | Fluidic fitting with integral face seal |
KR102479432B1 (en) * | 2016-12-12 | 2022-12-20 | 세페이드 | Integrated purification and measurement of DNA methylation and simultaneous measurement of mutations and/or mRNA expression levels in an automated reaction cartridge |
US20210072255A1 (en) | 2016-12-16 | 2021-03-11 | The Brigham And Women's Hospital, Inc. | System and method for protein corona sensor array for early detection of diseases |
US11237161B2 (en) | 2017-01-25 | 2022-02-01 | Cue Health Inc. | Systems and methods for enhanced detection and quantification of analytes |
CN110402394B (en) | 2017-03-01 | 2024-04-26 | 豪夫迈·罗氏有限公司 | Systems and methods for classifying biological samples regarding the presence of analytes |
WO2018170156A1 (en) * | 2017-03-15 | 2018-09-20 | President And Fellows Of Harvard College | Universal approach for decoupling sensitivity and dynamic range of a sensor |
US10934596B2 (en) | 2017-04-21 | 2021-03-02 | Uchicago Argonne, Llc | Automated microbial detection and quantification |
CN107225006B (en) | 2017-07-03 | 2018-04-03 | 南京岚煜生物科技有限公司 | More flux micro-fluidic chips based on the flowing of active control liquid |
KR101912942B1 (en) | 2017-07-24 | 2018-10-30 | 한국과학기술원 | Device for automatic discrimination of gene |
KR101941787B1 (en) * | 2017-11-13 | 2019-04-12 | 고려대학교 산학협력단 | Extracting apparatus for extracting target substance |
KR102245674B1 (en) * | 2017-11-17 | 2021-04-27 | 주식회사 엘지화학 | A Micro device for Solid Phase Extraction |
WO2019147525A1 (en) | 2018-01-26 | 2019-08-01 | Advanced Electrofluidic Systems, Llc | Method and apparatus for isolating and detecting biological and other particles |
US11125657B2 (en) | 2018-01-30 | 2021-09-21 | Ut-Battelle, Llc | Sampling probe |
BR112020023607A2 (en) | 2018-05-23 | 2021-02-17 | Abs Global, Inc. | systems and methods for focusing particles on microchannels |
CN108865654A (en) * | 2018-06-29 | 2018-11-23 | 苏州百源基因技术有限公司 | A kind of cell sorting device and method for separating |
EP3775834A4 (en) | 2018-07-09 | 2021-03-17 | Hewlett-Packard Development Company, L.P. | Analyte capturing devices with fluidic ejection devices |
CN111657965B (en) | 2018-09-14 | 2024-03-22 | 塔索公司 | Body fluid collection device and related methods |
AU2019362031A1 (en) * | 2018-10-19 | 2021-04-08 | Translate Bio, Inc. | Pumpless encapsulation of messenger RNA |
KR102594366B1 (en) | 2018-11-07 | 2023-10-27 | 시어 인코퍼레이티드 | Compositions, methods and systems for protein corona analysis and their uses |
US11298701B2 (en) | 2018-11-26 | 2022-04-12 | King Instrumentation Technologies | Microtiter plate mixing control system |
CN109622086B (en) * | 2019-01-31 | 2021-10-15 | 河南科技大学 | Microfluidic chip with preset magnetic beads, manufacturing method and microfluidic detection device |
CA3128022A1 (en) * | 2019-01-31 | 2020-08-06 | Samplix Aps | A microfluidic device and a method for provision of emulsion droplets |
CN113784618B (en) | 2019-04-18 | 2023-12-22 | 艾步思国际有限责任公司 | System and process for continuous addition of cryoprotectant |
US11383211B2 (en) * | 2019-04-29 | 2022-07-12 | Tokyo Electron Limited | Point-of-use dynamic concentration delivery system with high flow and high uniformity |
CN117169534A (en) | 2019-08-05 | 2023-12-05 | 禧尔公司 | Systems and methods for sample preparation, data generation, and protein crown analysis |
US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
US20230381778A1 (en) * | 2020-09-25 | 2023-11-30 | University Of Florida Research Foundation, Inc. | Devices, systems, and methods related to nucleic acid isolation |
CN114018787B (en) * | 2021-10-23 | 2023-10-20 | 广州市艾贝泰生物科技有限公司 | Particle detection unit, mixing system and mixing method |
CN116338162B (en) * | 2023-03-21 | 2024-01-12 | 江苏三联生物工程股份有限公司 | Sample application liquid, protein chip prepared by using sample application liquid and preparation method of protein chip |
CN116679043B (en) * | 2023-08-03 | 2023-11-03 | 天津大学 | Robot suitable for magnetophoresis analysis platform, preparation method and magnetophoresis analysis platform |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000060362A1 (en) * | 1999-04-08 | 2000-10-12 | Chung Chang Young | Apparatus for fast preparation and analysis of nucleic acids |
US20040053290A1 (en) * | 2000-01-11 | 2004-03-18 | Terbrueggen Robert Henry | Devices and methods for biochip multiplexing |
US20040086872A1 (en) * | 2002-10-31 | 2004-05-06 | Childers Winthrop D. | Microfluidic system for analysis of nucleic acids |
US20040151629A1 (en) * | 2003-01-31 | 2004-08-05 | Grant Pease | Microfluidic device with thin-film electronic devices |
Family Cites Families (344)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3190310A (en) | 1960-12-16 | 1965-06-22 | American Radiator & Standard | Gang valve arrangement |
US3352643A (en) | 1964-09-02 | 1967-11-14 | Hitachi Ltd | Liquid chromatography and chromatographs |
US3433257A (en) * | 1966-02-01 | 1969-03-18 | Ibm | Diaphragm type fluid logic latch |
US3568692A (en) * | 1967-11-27 | 1971-03-09 | Bowles Eng Corp | Optical machining process |
US3610274A (en) | 1969-10-08 | 1971-10-05 | Brown & Sharpe Mfg | Fluid logic circuit |
US4113665A (en) | 1977-02-03 | 1978-09-12 | Ameron, Inc. | Coatings prepared from trialkoxysilanes |
US4558845A (en) | 1982-09-22 | 1985-12-17 | Hunkapiller Michael W | Zero dead volume valve |
US4703913A (en) | 1982-09-22 | 1987-11-03 | California Institute Of Technology | Diaphragm valve |
US4963498A (en) * | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
GB8523166D0 (en) | 1985-09-19 | 1985-10-23 | Yarsley Technical Centre Ltd | Scratch resistant coatings |
US5085757A (en) * | 1987-11-25 | 1992-02-04 | Northeastern University | Integrated temperature control/alignment system for high performance capillary electrophoretic apparatus |
US5523231A (en) | 1990-02-13 | 1996-06-04 | Amersham International Plc | Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules |
US6176962B1 (en) * | 1990-02-28 | 2001-01-23 | Aclara Biosciences, Inc. | Methods for fabricating enclosed microchannel structures |
US5750015A (en) | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields |
US5935401A (en) * | 1996-09-18 | 1999-08-10 | Aclara Biosciences | Surface modified electrophoretic chambers |
US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
US5387505A (en) * | 1990-05-04 | 1995-02-07 | Eastman Kodak Company | Preparation and isolation of single-stranded biotinylated nucleic acids by heat avidin-biotin cleavage |
SE470347B (en) | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Microstructure for fluid flow systems and process for manufacturing such a system |
EP0459241B1 (en) | 1990-05-29 | 1994-10-26 | Waters Investments Limited | Process and apparatus for effecting capillary electrophoresis |
US5364759B2 (en) | 1991-01-31 | 1999-07-20 | Baylor College Medicine | Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats |
US5304487A (en) | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
US5726026A (en) * | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
US5637469A (en) | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
US5587128A (en) | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices |
DE69319427T2 (en) | 1992-05-01 | 1998-12-10 | Univ Pennsylvania | ANALYSIS OF MEASURING THE FLOW RESISTANCE |
US5275645A (en) * | 1992-11-24 | 1994-01-04 | Ameron, Inc. | Polysiloxane coating |
US5482836A (en) * | 1993-01-14 | 1996-01-09 | The Regents Of The University Of California | DNA purification by triplex-affinity capture and affinity capture electrophoresis |
EP0620432B1 (en) | 1993-04-15 | 2004-08-25 | Zeptosens AG | Method for controlling sample introduction in microcolumn separation techniques and sampling device |
US5482845A (en) | 1993-09-24 | 1996-01-09 | The Trustees Of Columbia University In The City Of New York | Method for construction of normalized cDNA libraries |
US5776748A (en) * | 1993-10-04 | 1998-07-07 | President And Fellows Of Harvard College | Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor |
US5453163A (en) | 1993-10-29 | 1995-09-26 | Yan; Chao | Electrokinetic packing of capillary columns |
US6129828A (en) | 1996-09-06 | 2000-10-10 | Nanogen, Inc. | Apparatus and methods for active biological sample preparation |
US6358385B1 (en) * | 1993-12-17 | 2002-03-19 | The Perkin-Elmer Corporation | Polymers for separation of biomolecules by capillary electrophoresis |
US5639428A (en) | 1994-07-19 | 1997-06-17 | Becton Dickinson And Company | Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay |
US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
US5705628A (en) * | 1994-09-20 | 1998-01-06 | Whitehead Institute For Biomedical Research | DNA purification and isolation using magnetic particles |
WO1998053300A2 (en) | 1997-05-23 | 1998-11-26 | Lynx Therapeutics, Inc. | System and apparaus for sequential processing of analytes |
US5571410A (en) | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
JP3220158B2 (en) * | 1994-11-14 | 2001-10-22 | トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | Mesoscale sample pretreatment devices and systems for analyte determination and processing |
US5775371A (en) | 1995-03-08 | 1998-07-07 | Abbott Laboratories | Valve control |
US5741462A (en) * | 1995-04-25 | 1998-04-21 | Irori | Remotely programmable matrices with memories |
US5856174A (en) * | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US6168948B1 (en) * | 1995-06-29 | 2001-01-02 | Affymetrix, Inc. | Miniaturized genetic analysis systems and methods |
US5872010A (en) * | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
US20020068357A1 (en) * | 1995-09-28 | 2002-06-06 | Mathies Richard A. | Miniaturized integrated nucleic acid processing and analysis device and method |
US5705813A (en) * | 1995-11-01 | 1998-01-06 | Hewlett-Packard Company | Integrated planar liquid handling system for maldi-TOF MS |
EP0779512B1 (en) | 1995-12-14 | 2001-10-31 | Hewlett-Packard Company, A Delaware Corporation | Column for capillary chromatographic separations |
US5863502A (en) * | 1996-01-24 | 1999-01-26 | Sarnoff Corporation | Parallel reaction cassette and associated devices |
US5948684A (en) * | 1997-03-31 | 1999-09-07 | University Of Washington | Simultaneous analyte determination and reference balancing in reference T-sensor devices |
US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
US5942443A (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US5994064A (en) | 1996-04-24 | 1999-11-30 | Identigene, Inc. | Simple and complex tandem repeats with DNA typing method |
US6387707B1 (en) * | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
AU3570797A (en) | 1996-06-14 | 1998-01-07 | University Of Washington | Absorption-enhanced differential extraction device |
BR9710054A (en) | 1996-06-28 | 2000-01-11 | Caliper Techn Corp | Apparatus for separating test compounds for an effect on a biochemical system and for detecting a effect of a test compound on a biochemical system, procedures for determining whether a sample contains a compound capable of affecting a biochemical system, for separating a plurality of test compounds for an effect on a biochemical system and uses of a microfluidic system and a test substrate. |
US6074827A (en) * | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
US6136212A (en) | 1996-08-12 | 2000-10-24 | The Regents Of The University Of Michigan | Polymer-based micromachining for microfluidic devices |
US6110343A (en) | 1996-10-04 | 2000-08-29 | Lockheed Martin Energy Research Corporation | Material transport method and apparatus |
WO1998022625A1 (en) * | 1996-11-20 | 1998-05-28 | The Regents Of The University Of Michigan | Microfabricated isothermal nucleic acid amplification devices and methods |
US6306588B1 (en) * | 1997-02-07 | 2001-10-23 | Invitrogen Corporation | Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof |
US6117634A (en) * | 1997-03-05 | 2000-09-12 | The Reagents Of The University Of Michigan | Nucleic acid sequencing and mapping |
WO1998045684A1 (en) * | 1997-04-04 | 1998-10-15 | Biosite Diagnostics, Inc. | Methods for concentrating ligands using magnetic particles |
US6235471B1 (en) | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
US6872527B2 (en) * | 1997-04-16 | 2005-03-29 | Xtrana, Inc. | Nucleic acid archiving |
US6632619B1 (en) | 1997-05-16 | 2003-10-14 | The Governors Of The University Of Alberta | Microfluidic system and methods of use |
EP0981408B1 (en) | 1997-05-16 | 2004-04-21 | Alberta Research Council | Microfluidic system and methods of use |
US5900130A (en) | 1997-06-18 | 1999-05-04 | Alcara Biosciences, Inc. | Method for sample injection in microchannel device |
GB9713597D0 (en) | 1997-06-28 | 1997-09-03 | Sec Dep Of The Home Department | Improvements in and relating to forensic identification |
US6073482A (en) | 1997-07-21 | 2000-06-13 | Ysi Incorporated | Fluid flow module |
US6190616B1 (en) * | 1997-09-11 | 2001-02-20 | Molecular Dynamics, Inc. | Capillary valve, connector, and router |
WO1999014368A2 (en) * | 1997-09-15 | 1999-03-25 | Whitehead Institute For Biomedical Research | Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device |
US6007775A (en) | 1997-09-26 | 1999-12-28 | University Of Washington | Multiple analyte diffusion based chemical sensor |
US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
AU1517999A (en) | 1997-10-15 | 1999-05-03 | Aclara Biosciences, Inc. | Laminate microstructure device and method for making same |
US6120985A (en) | 1997-10-31 | 2000-09-19 | Bbi Bioseq, Inc. | Pressure-enhanced extraction and purification |
US5860594A (en) * | 1997-12-19 | 1999-01-19 | Carrier Corporation | Method and apparatus for changing operational modes of a transport refrigeration system |
ES2309022T3 (en) * | 1997-12-24 | 2008-12-16 | Cepheid | DEVICE AND PROCEDURE FOR LISIS. |
US6200814B1 (en) | 1998-01-20 | 2001-03-13 | Biacore Ab | Method and device for laminar flow on a sensing surface |
US6167910B1 (en) | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
US6685809B1 (en) * | 1999-02-04 | 2004-02-03 | Ut-Battelle, Llc | Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels |
US6251343B1 (en) | 1998-02-24 | 2001-06-26 | Caliper Technologies Corp. | Microfluidic devices and systems incorporating cover layers |
WO1999046591A2 (en) | 1998-03-10 | 1999-09-16 | Strategic Diagnostics, Inc. | Integrated assay device and methods of production and use |
US6979424B2 (en) * | 1998-03-17 | 2005-12-27 | Cepheid | Integrated sample analysis device |
US6534262B1 (en) * | 1998-05-14 | 2003-03-18 | Whitehead Institute For Biomedical Research | Solid phase technique for selectively isolating nucleic acids |
US6627446B1 (en) | 1998-07-02 | 2003-09-30 | Amersham Biosciences (Sv) Corp | Robotic microchannel bioanalytical instrument |
US6787111B2 (en) | 1998-07-02 | 2004-09-07 | Amersham Biosciences (Sv) Corp. | Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis |
US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
US6387234B1 (en) | 1998-08-31 | 2002-05-14 | Iowa State University Research Foundation, Inc. | Integrated multiplexed capillary electrophoresis system |
US6103199A (en) | 1998-09-15 | 2000-08-15 | Aclara Biosciences, Inc. | Capillary electroflow apparatus and method |
US6572830B1 (en) * | 1998-10-09 | 2003-06-03 | Motorola, Inc. | Integrated multilayered microfludic devices and methods for making the same |
GB9900298D0 (en) | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
US6475364B1 (en) * | 1999-02-02 | 2002-11-05 | Caliper Technologies Corp. | Methods, devices and systems for characterizing proteins |
CA2359901A1 (en) * | 1999-02-16 | 2000-08-24 | Pe Corporation (Ny) | Bead dispensing system |
ATE508200T1 (en) | 1999-02-23 | 2011-05-15 | Caliper Life Sciences Inc | SEQUENCING THROUGH INCORPORATION |
WO2000050870A1 (en) * | 1999-02-26 | 2000-08-31 | Mosaic Technologies | Biochemical purification devices with immobilized capture probes and their uses |
EP1411340A3 (en) * | 1999-02-26 | 2004-05-19 | EXACT Sciences Corporation | Biochemical purification devices with immobilized capture probes and their uses |
US6319476B1 (en) | 1999-03-02 | 2001-11-20 | Perseptive Biosystems, Inc. | Microfluidic connector |
US7150994B2 (en) * | 1999-03-03 | 2006-12-19 | Symyx Technologies, Inc. | Parallel flow process optimization reactor |
US6048100A (en) * | 1999-03-10 | 2000-04-11 | Industrial Label Corp. | Resealable closure for a bag |
US6994986B2 (en) * | 1999-03-17 | 2006-02-07 | The Board Of Trustees Of The Leland Stanford University | In vitro synthesis of polypeptides by optimizing amino acid metabolism |
JP3746658B2 (en) | 1999-04-12 | 2006-02-15 | 株式会社日立製作所 | Method and apparatus for producing probe array using fine particles |
US6322683B1 (en) | 1999-04-14 | 2001-11-27 | Caliper Technologies Corp. | Alignment of multicomponent microfabricated structures |
US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
NZ516278A (en) | 1999-06-22 | 2004-03-26 | Invitrogen Corp | Improved primers and methods for the detection and discrimination of nucleic acids |
KR100865105B1 (en) | 1999-06-28 | 2008-10-24 | 캘리포니아 인스티튜트 오브 테크놀로지 | Microfabricated elastomeric valve and pump systems |
US6929030B2 (en) | 1999-06-28 | 2005-08-16 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US6899137B2 (en) | 1999-06-28 | 2005-05-31 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US6818395B1 (en) * | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US6533914B1 (en) * | 1999-07-08 | 2003-03-18 | Shaorong Liu | Microfabricated injector and capillary array assembly for high-resolution and high throughput separation |
JP2003505059A (en) * | 1999-07-28 | 2003-02-12 | ジェンセット | Integration of biochemical protocols in continuous flow microfluidic devices |
US6977145B2 (en) * | 1999-07-28 | 2005-12-20 | Serono Genetics Institute S.A. | Method for carrying out a biochemical protocol in continuous flow in a microreactor |
US6423536B1 (en) | 1999-08-02 | 2002-07-23 | Molecular Dynamics, Inc. | Low volume chemical and biochemical reaction system |
US6524456B1 (en) * | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
US6824663B1 (en) | 1999-08-27 | 2004-11-30 | Aclara Biosciences, Inc. | Efficient compound distribution in microfluidic devices |
US6846626B1 (en) | 1999-09-01 | 2005-01-25 | Genome Technologies, Llc | Method for amplifying sequences from unknown DNA |
US20020151089A1 (en) * | 1999-09-15 | 2002-10-17 | Chapman William H. | Separating components of biological samples |
US6623945B1 (en) * | 1999-09-16 | 2003-09-23 | Motorola, Inc. | System and method for microwave cell lysing of small samples |
EP1218543A2 (en) | 1999-09-29 | 2002-07-03 | Solexa Ltd. | Polynucleotide sequencing |
WO2002037096A1 (en) | 1999-10-01 | 2002-05-10 | University Of California | Microfabricated liquid sample loading system |
JP3896739B2 (en) * | 1999-10-29 | 2007-03-22 | 株式会社日立製作所 | Capillary electrophoresis device |
WO2001032930A1 (en) | 1999-11-04 | 2001-05-10 | California Institute Of Technology | Methods and apparatuses for analyzing polynucleotide sequences |
US6705345B1 (en) * | 1999-11-08 | 2004-03-16 | The Trustees Of Boston University | Micro valve arrays for fluid flow control |
US6120184A (en) | 1999-11-17 | 2000-09-19 | Stone Container Corporation | Bag apparatus with reclosable pour spout |
US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
CA2290731A1 (en) | 1999-11-26 | 2001-05-26 | D. Jed Harrison | Apparatus and method for trapping bead based reagents within microfluidic analysis system |
WO2001055454A1 (en) * | 2000-01-28 | 2001-08-02 | Althea Technologies, Inc. | Methods for analysis of gene expression |
SE0000300D0 (en) * | 2000-01-30 | 2000-01-30 | Amersham Pharm Biotech Ab | Microfluidic assembly, covering method for the manufacture of the assembly and the use of the assembly |
US6807490B1 (en) | 2000-02-15 | 2004-10-19 | Mark W. Perlin | Method for DNA mixture analysis |
CA2400159A1 (en) | 2000-02-23 | 2001-08-30 | Zyomyx, Inc. | Chips having elevated sample surfaces |
EP1268696A4 (en) | 2000-02-28 | 2005-01-26 | Adsil Lc | Silane-based, coating compositions, coated articles obtained therefrom and methods of using same |
EP1269171B1 (en) | 2000-03-07 | 2006-05-31 | Northeastern University | Parallel array of independent thermostats for column separations |
WO2001072335A2 (en) * | 2000-03-28 | 2001-10-04 | Queen's University At Kingston | Methods for effecting neuroprotection using a potassium channel modulator |
US7279146B2 (en) * | 2003-04-17 | 2007-10-09 | Fluidigm Corporation | Crystal growth devices and systems, and methods for using same |
SE0001768D0 (en) | 2000-05-12 | 2000-05-12 | Helen Andersson | Microfluidic flow cell for manipulation of particles |
US6531282B1 (en) * | 2000-05-30 | 2003-03-11 | Oligotrail, Llc | Multiplex amplification and analysis of selected STR loci |
US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
WO2002001081A2 (en) | 2000-06-23 | 2002-01-03 | Micronics, Inc. | Valve for use in microfluidic structures |
US6885982B2 (en) * | 2000-06-27 | 2005-04-26 | Fluidigm Corporation | Object oriented microfluidic design method and system |
AU2001273057A1 (en) | 2000-06-27 | 2002-01-08 | Fluidigm Corporation | A microfluidic design automation method and system |
US6734401B2 (en) * | 2000-06-28 | 2004-05-11 | 3M Innovative Properties Company | Enhanced sample processing devices, systems and methods |
US6531041B1 (en) * | 2000-07-20 | 2003-03-11 | Symyx Technologies, Inc. | Multiplexed capillary electrophoresis system with rotatable photodetector |
US7004184B2 (en) * | 2000-07-24 | 2006-02-28 | The Reagents Of The University Of Michigan | Compositions and methods for liquid metering in microchannels |
US20020048534A1 (en) | 2000-08-24 | 2002-04-25 | David Storek | Sample preparing arrangement and a method relating to such an arrangement |
EP1978110B1 (en) | 2000-09-06 | 2010-05-26 | Transnetyx, Inc. | Computer-based method and system for screening genomic DNA |
EP2299256A3 (en) * | 2000-09-15 | 2012-10-10 | California Institute Of Technology | Microfabricated crossflow devices and methods |
EP1322936A2 (en) | 2000-10-03 | 2003-07-02 | California Institute Of Technology | Microfluidic devices and methods of use |
US7097809B2 (en) | 2000-10-03 | 2006-08-29 | California Institute Of Technology | Combinatorial synthesis system |
US6782746B1 (en) | 2000-10-24 | 2004-08-31 | Sandia National Laboratories | Mobile monolithic polymer elements for flow control in microfluidic devices |
DE60001177T2 (en) | 2000-10-25 | 2003-10-23 | Bruker Biospin Gmbh | LC-NMR system containing a device for capturing at least one component of a chromatography flow |
CA2427669A1 (en) | 2000-11-03 | 2002-06-06 | Clinical Micro Sensors, Inc. | Devices and methods for biochip multiplexing |
CA2361980A1 (en) * | 2000-11-13 | 2002-05-13 | Arkmount Systems Inc. | Heat sealing and cutting mechanism and container forming apparatus incorporating the same |
EP1345698A4 (en) | 2000-11-16 | 2006-05-17 | Fluidigm Corp | Microfluidic devices for introducing and dispensing fluids from microfluidic systems |
US6521188B1 (en) * | 2000-11-22 | 2003-02-18 | Industrial Technology Research Institute | Microfluidic actuator |
US6527003B1 (en) * | 2000-11-22 | 2003-03-04 | Industrial Technology Research | Micro valve actuator |
GB0028647D0 (en) | 2000-11-24 | 2001-01-10 | Nextgen Sciences Ltd | Apparatus for chemical assays |
SE0004351D0 (en) | 2000-11-27 | 2000-11-27 | Helen Andersson | System and method for time-controlled liquid handling for reactions and processes in a microfluidic flow cell system |
US20020123538A1 (en) | 2000-12-29 | 2002-09-05 | Peiguang Zhou | Hot-melt adhesive based on blend of amorphous and crystalline polymers for multilayer bonding |
US6767194B2 (en) | 2001-01-08 | 2004-07-27 | President And Fellows Of Harvard College | Valves and pumps for microfluidic systems and method for making microfluidic systems |
US20020098097A1 (en) * | 2001-01-22 | 2002-07-25 | Angad Singh | Magnetically-actuated micropump |
WO2002072264A1 (en) * | 2001-03-09 | 2002-09-19 | Biomicro Systems, Inc. | Method and system for microfluidic interfacing to arrays |
US6852287B2 (en) * | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US20020159920A1 (en) | 2001-04-03 | 2002-10-31 | Weigl Bernhard H. | Multiple redundant microfluidic structures cross reference to related applications |
ATE500051T1 (en) * | 2001-04-06 | 2011-03-15 | Fluidigm Corp | POLYMER SURFACE MODIFICATION |
US6752922B2 (en) | 2001-04-06 | 2004-06-22 | Fluidigm Corporation | Microfluidic chromatography |
US6802342B2 (en) | 2001-04-06 | 2004-10-12 | Fluidigm Corporation | Microfabricated fluidic circuit elements and applications |
US6960437B2 (en) * | 2001-04-06 | 2005-11-01 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
AU2002359234B2 (en) | 2001-04-25 | 2007-11-15 | Cornell Research Foundation, Inc. | Devices and methods for pharmacokinetic-based cell culture system |
US7318912B2 (en) * | 2001-06-07 | 2008-01-15 | Nanostream, Inc. | Microfluidic systems and methods for combining discrete fluid volumes |
JP2002370200A (en) | 2001-06-12 | 2002-12-24 | Kawamura Inst Of Chem Res | Method of manufacturing miniature valve mechanism |
US6629820B2 (en) | 2001-06-26 | 2003-10-07 | Micralyne Inc. | Microfluidic flow control device |
GB0119959D0 (en) * | 2001-08-16 | 2001-10-10 | Sec Dep Of The Home Department | Improvements in and relating to analysis |
US20040013536A1 (en) * | 2001-08-31 | 2004-01-22 | Hower Robert W | Micro-fluidic pump |
US20030095897A1 (en) * | 2001-08-31 | 2003-05-22 | Grate Jay W. | Flow-controlled magnetic particle manipulation |
JP2003074462A (en) * | 2001-09-03 | 2003-03-12 | Fukuoka Institute Of Technology | Magnetic fluid pump |
JP3685119B2 (en) * | 2001-10-18 | 2005-08-17 | 株式会社日立製作所 | Biomolecule recovery method |
JP4381670B2 (en) | 2001-10-30 | 2009-12-09 | 株式会社日立製作所 | Reactor |
WO2003040395A2 (en) * | 2001-11-07 | 2003-05-15 | Applera Corporation | Universal nucleotides for nucleic acid analysis |
JP4355210B2 (en) * | 2001-11-30 | 2009-10-28 | フルイディグム コーポレイション | Microfluidic device and method of using microfluidic device |
US7691333B2 (en) | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
US6864480B2 (en) * | 2001-12-19 | 2005-03-08 | Sau Lan Tang Staats | Interface members and holders for microfluidic array devices |
US6532997B1 (en) * | 2001-12-28 | 2003-03-18 | 3M Innovative Properties Company | Sample processing device with integral electrophoresis channels |
EP1468116A2 (en) * | 2002-01-16 | 2004-10-20 | Dynal Biotech ASA | Method for isolating nucleic acids and protein from a single sample |
US6581441B1 (en) | 2002-02-01 | 2003-06-24 | Perseptive Biosystems, Inc. | Capillary column chromatography process and system |
WO2003068402A1 (en) | 2002-02-13 | 2003-08-21 | Nanostream, Inc. | Microfluidic separation column devices and fabrication methods |
US6685442B2 (en) * | 2002-02-20 | 2004-02-03 | Sandia National Laboratories | Actuator device utilizing a conductive polymer gel |
AU2003218114B2 (en) * | 2002-03-11 | 2008-09-18 | Athenix Corporation | Integrated system for high throughput capture of genetic diversity |
WO2003085379A2 (en) | 2002-04-01 | 2003-10-16 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US7312085B2 (en) | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
EP2302389B1 (en) | 2002-05-09 | 2018-01-24 | The University of Chicago | Device and method for pressure-driven plug transport and reaction |
US20030217923A1 (en) * | 2002-05-24 | 2003-11-27 | Harrison D. Jed | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
US7215640B2 (en) * | 2002-07-11 | 2007-05-08 | Hitachi, Ltd. | Method and apparatus for path configuration in networks |
KR100490898B1 (en) * | 2002-07-12 | 2005-05-24 | 한국전자통신연구원 | Pointer Generation Apparatus and Method for Structured Data Transfer in AAL1 |
US20040101444A1 (en) | 2002-07-15 | 2004-05-27 | Xeotron Corporation | Apparatus and method for fluid delivery to a hybridization station |
US6786708B2 (en) | 2002-07-18 | 2004-09-07 | The Regents Of The University Of Michigan | Laminated devices and methods of making same |
US20040018611A1 (en) * | 2002-07-23 | 2004-01-29 | Ward Michael Dennis | Microfluidic devices for high gradient magnetic separation |
WO2004011681A1 (en) | 2002-07-26 | 2004-02-05 | Applera Corporation | Microfluidic device including purification column with excess diluent, and method |
US7198759B2 (en) * | 2002-07-26 | 2007-04-03 | Applera Corporation | Microfluidic devices, methods, and systems |
ATE358533T1 (en) * | 2002-08-02 | 2007-04-15 | Ge Healthcare Sv Corp | INTEGRATED MICROCHIP DESIGN |
US7244961B2 (en) | 2002-08-02 | 2007-07-17 | Silicon Valley Scientific | Integrated system with modular microfluidic components |
US20040038385A1 (en) * | 2002-08-26 | 2004-02-26 | Langlois Richard G. | System for autonomous monitoring of bioagents |
US20040197845A1 (en) | 2002-08-30 | 2004-10-07 | Arjang Hassibi | Methods and apparatus for pathogen detection, identification and/or quantification |
US7605002B2 (en) | 2002-09-06 | 2009-10-20 | Epigem Limited | Modular microfluidic system |
US7157228B2 (en) * | 2002-09-09 | 2007-01-02 | Bioarray Solutions Ltd. | Genetic analysis and authentication |
JP3725109B2 (en) * | 2002-09-19 | 2005-12-07 | 財団法人生産技術研究奨励会 | Microfluidic device |
TW590982B (en) * | 2002-09-27 | 2004-06-11 | Agnitio Science & Technology I | Micro-fluid driving device |
JP5695287B2 (en) * | 2002-10-02 | 2015-04-01 | カリフォルニア インスティテュート オブ テクノロジー | Nucleic acid analysis of microfluids |
US7217542B2 (en) | 2002-10-31 | 2007-05-15 | Hewlett-Packard Development Company, L.P. | Microfluidic system for analyzing nucleic acids |
JP2004180594A (en) | 2002-12-04 | 2004-07-02 | Shimadzu Corp | Cell-culturing device |
AU2003298938A1 (en) | 2002-12-05 | 2004-06-30 | Protasis Corporation | Configurable microfluidic substrate assembly |
WO2004055646A2 (en) | 2002-12-13 | 2004-07-01 | Gene Codes Forensics, Inc. | Method for profiling and identifying persons by using data samples |
US20050266582A1 (en) | 2002-12-16 | 2005-12-01 | Modlin Douglas N | Microfluidic system with integrated permeable membrane |
JP2006512092A (en) | 2002-12-30 | 2006-04-13 | ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア | Method and apparatus for pathogen detection and analysis |
US7049558B2 (en) | 2003-01-27 | 2006-05-23 | Arcturas Bioscience, Inc. | Apparatus and method for heating microfluidic volumes and moving fluids |
US7575865B2 (en) | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
DE602004024034D1 (en) | 2003-01-29 | 2009-12-24 | 454 Corp | NUCLEIC ACID AMPLIFICATION BASED ON KINGGEL EMULSION |
WO2004067162A2 (en) | 2003-01-30 | 2004-08-12 | Ciphergen Biosystems Inc. | Apparatus for microfluidic processing and reading of biochip arrays |
JP4119275B2 (en) | 2003-02-18 | 2008-07-16 | 忠弘 大見 | Diaphragm valve for vacuum exhaust system |
US7476363B2 (en) | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
US7745116B2 (en) | 2003-04-08 | 2010-06-29 | Pacific Biosciences Of California, Inc. | Composition and method for nucleic acid sequencing |
WO2004098757A2 (en) | 2003-05-06 | 2004-11-18 | New Jersey Institute Of Technology | Microfluidic mixing using flow pulsing |
FR2855076B1 (en) | 2003-05-21 | 2006-09-08 | Inst Curie | MICROFLUIDIC DEVICE |
US7063304B2 (en) | 2003-07-11 | 2006-06-20 | Entegris, Inc. | Extended stroke valve and diaphragm |
US7943393B2 (en) * | 2003-07-14 | 2011-05-17 | Phynexus, Inc. | Method and device for extracting an analyte |
US7267510B2 (en) * | 2003-07-29 | 2007-09-11 | Cable Lock, Inc. | Foundation pile having a spiral ridge |
US7357898B2 (en) * | 2003-07-31 | 2008-04-15 | Agency For Science, Technology And Research | Microfluidics packages and methods of using same |
US20050047967A1 (en) * | 2003-09-03 | 2005-03-03 | Industrial Technology Research Institute | Microfluidic component providing multi-directional fluid movement |
WO2005030995A1 (en) | 2003-09-23 | 2005-04-07 | University Of Missouri | Methods of synthesizing polynucleotides using thermostable enzymes |
TW200702660A (en) | 2003-11-21 | 2007-01-16 | Ebara Corp | Microfluidic treatment method and device |
US7939249B2 (en) * | 2003-12-24 | 2011-05-10 | 3M Innovative Properties Company | Methods for nucleic acid isolation and kits using a microfluidic device and concentration step |
DE602005020249D1 (en) | 2004-02-02 | 2010-05-12 | Silicon Valley Scient Inc | INTEGRATED SYSTEM WITH MODULAR MICROFLUIDIC COMPONENTS |
US8043849B2 (en) * | 2004-02-24 | 2011-10-25 | Thermal Gradient | Thermal cycling device |
CN1942222B (en) | 2004-03-05 | 2011-08-31 | 麦克罗斯塔克公司 | Selective bonding for forming a microvalve |
US7077175B2 (en) | 2004-04-09 | 2006-07-18 | Hongfeng Yin | Particle packing of microdevice |
CA2994321C (en) | 2004-05-03 | 2023-08-08 | Handylab, Inc. | A microfluidic device and methods for processing polynucleotide-containing samples |
JP4683538B2 (en) | 2004-05-06 | 2011-05-18 | セイコーインスツル株式会社 | Analysis system and analysis method including microchip for analysis |
JP3952036B2 (en) | 2004-05-13 | 2007-08-01 | コニカミノルタセンシング株式会社 | Microfluidic device, test solution test method and test system |
JP4372616B2 (en) | 2004-05-28 | 2009-11-25 | アイダエンジニアリング株式会社 | Microvalve, micropump and microchip incorporating them |
US7799553B2 (en) | 2004-06-01 | 2010-09-21 | The Regents Of The University Of California | Microfabricated integrated DNA analysis system |
US20050272144A1 (en) | 2004-06-08 | 2005-12-08 | Konica Minolta Medical & Graphic, Inc. | Micro-reactor for improving efficiency of liquid mixing and reaction |
US20060057209A1 (en) * | 2004-09-16 | 2006-03-16 | Predicant Biosciences, Inc. | Methods, compositions and devices, including microfluidic devices, comprising coated hydrophobic surfaces |
US7585663B2 (en) | 2004-08-26 | 2009-09-08 | Applied Biosystems, Llc | Thermal device, system, and method, for fluid processing device |
EP2261650A3 (en) | 2004-09-15 | 2011-07-06 | IntegenX Inc. | Microfluidic devices |
JP2006090386A (en) | 2004-09-22 | 2006-04-06 | Kitz Sct:Kk | Diaphragm valve |
GB0421529D0 (en) | 2004-09-28 | 2004-10-27 | Landegren Gene Technology Ab | Microfluidic structure |
US7832429B2 (en) * | 2004-10-13 | 2010-11-16 | Rheonix, Inc. | Microfluidic pump and valve structures and fabrication methods |
WO2006044458A2 (en) | 2004-10-13 | 2006-04-27 | University Of Virginia Patent Foundation | Electrostatic actuation for management of flow |
WO2006054689A1 (en) * | 2004-11-22 | 2006-05-26 | Nissui Pharmaceutical Co., Ltd. | Microchip |
KR100634525B1 (en) | 2004-11-23 | 2006-10-16 | 삼성전자주식회사 | Microfluidic device comprising a microchannel disposed of a plurality of electromagnets, method for mixing a sample and method for lysis cells using the same |
WO2006071470A2 (en) | 2004-12-03 | 2006-07-06 | California Institute Of Technology | Microfluidic devices with chemical reaction circuits |
US8883487B2 (en) | 2004-12-23 | 2014-11-11 | Abbott Point Of Care Inc. | Molecular diagnostics system and methods |
US20060163143A1 (en) | 2005-01-26 | 2006-07-27 | Chirica Gabriela S | Microliter scale solid phase extraction devices |
CA2496481A1 (en) | 2005-02-08 | 2006-08-09 | Mds Inc., Doing Business Through It's Mds Sciex Division | Method and apparatus for sample deposition |
JP3921233B2 (en) | 2005-02-10 | 2007-05-30 | 松下電器産業株式会社 | Fluid chip, fluid movement control method using the same, and chemical reaction device |
US20070017812A1 (en) * | 2005-03-30 | 2007-01-25 | Luc Bousse | Optimized Sample Injection Structures in Microfluidic Separations |
US20070015179A1 (en) * | 2005-04-26 | 2007-01-18 | Trustees Of Boston University | Plastic microfluidic chip and methods for isolation of nucleic acids from biological samples |
US20060263789A1 (en) | 2005-05-19 | 2006-11-23 | Robert Kincaid | Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using |
US8206974B2 (en) | 2005-05-19 | 2012-06-26 | Netbio, Inc. | Ruggedized apparatus for analysis of nucleic acid and proteins |
US7316766B2 (en) | 2005-05-27 | 2008-01-08 | Taidoc Technology Corporation | Electrochemical biosensor strip |
WO2007002579A2 (en) | 2005-06-23 | 2007-01-04 | Bioveris Corporation | Assay cartridges and methods for point of care instruments |
US7817273B2 (en) | 2005-06-30 | 2010-10-19 | Life Technologies Corporation | Two-dimensional spectral imaging system |
US20070031865A1 (en) * | 2005-07-07 | 2007-02-08 | David Willoughby | Novel Process for Construction of a DNA Library |
US7428848B2 (en) | 2005-08-09 | 2008-09-30 | Cfd Research Corporation | Electrostatic sampler and method |
US20070184463A1 (en) | 2005-09-30 | 2007-08-09 | Caliper Life Sciences, Inc. | Microfluidic device for purifying a biological component using magnetic beads |
US7709544B2 (en) | 2005-10-25 | 2010-05-04 | Massachusetts Institute Of Technology | Microstructure synthesis by flow lithography and polymerization |
US20080311585A1 (en) | 2005-11-02 | 2008-12-18 | Affymetrix, Inc. | System and method for multiplex liquid handling |
US20070113908A1 (en) | 2005-11-18 | 2007-05-24 | The Ohio State University And Bioloc, Inc. | Valve for microfluidic chips |
US20070122819A1 (en) * | 2005-11-25 | 2007-05-31 | Industrial Technology Research Institute | Analyte assay structure in microfluidic chip for quantitative analysis and method for using the same |
US20080179255A1 (en) | 2007-01-29 | 2008-07-31 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Fluidic devices |
US7763453B2 (en) | 2005-11-30 | 2010-07-27 | Micronics, Inc. | Microfluidic mixing and analytic apparatus |
JP4593451B2 (en) | 2005-12-05 | 2010-12-08 | セイコーインスツル株式会社 | Microreactor system and liquid feeding method |
CN101004423B (en) | 2006-01-19 | 2011-12-28 | 博奥生物有限公司 | Card, kit system in use for analyzing sample of liquid |
US7976795B2 (en) | 2006-01-19 | 2011-07-12 | Rheonix, Inc. | Microfluidic systems |
US7749365B2 (en) | 2006-02-01 | 2010-07-06 | IntegenX, Inc. | Optimized sample injection structures in microfluidic separations |
JP5063616B2 (en) | 2006-02-03 | 2012-10-31 | インテジェニックス インコーポレイテッド | Microfluidic device |
WO2007106579A2 (en) | 2006-03-15 | 2007-09-20 | Micronics, Inc. | Integrated nucleic acid assays |
US7766033B2 (en) | 2006-03-22 | 2010-08-03 | The Regents Of The University Of California | Multiplexed latching valves for microfluidic devices and processors |
US9063132B2 (en) * | 2006-03-29 | 2015-06-23 | Inverness Medical Switzerland Gmbh | Assay device and method |
KR100785010B1 (en) | 2006-04-06 | 2007-12-11 | 삼성전자주식회사 | Method and apparatus for the purification of nucleic acids on hydrophilic surface of solid support using hydrogen bonding |
EP2530168B1 (en) * | 2006-05-11 | 2015-09-16 | Raindance Technologies, Inc. | Microfluidic Devices |
WO2007136840A2 (en) * | 2006-05-20 | 2007-11-29 | Codon Devices, Inc. | Nucleic acid library design and assembly |
US8296088B2 (en) | 2006-06-02 | 2012-10-23 | Luminex Corporation | Systems and methods for performing measurements of one or more materials |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
AU2007265628B2 (en) | 2006-06-23 | 2012-12-06 | Perkinelmer Health Sciences, Inc. | Methods and devices for microfluidic point-of-care immunoassays |
US7629124B2 (en) * | 2006-06-30 | 2009-12-08 | Canon U.S. Life Sciences, Inc. | Real-time PCR in micro-channels |
AU2007278425B2 (en) | 2006-07-28 | 2011-11-17 | Qiagen Gmbh | Device for processing samples |
WO2008024319A2 (en) | 2006-08-20 | 2008-02-28 | Codon Devices, Inc. | Microfluidic devices for nucleic acid assembly |
US20080131327A1 (en) | 2006-09-28 | 2008-06-05 | California Institute Of Technology | System and method for interfacing with a microfluidic chip |
WO2008052138A2 (en) * | 2006-10-25 | 2008-05-02 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated dna analysis system using same |
US20080242560A1 (en) | 2006-11-21 | 2008-10-02 | Gunderson Kevin L | Methods for generating amplified nucleic acid arrays |
CA2672315A1 (en) | 2006-12-14 | 2008-06-26 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes using large scale fet arrays |
EP2121983A2 (en) | 2007-02-02 | 2009-11-25 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
WO2008115626A2 (en) | 2007-02-05 | 2008-09-25 | Microchip Biotechnologies, Inc. | Microfluidic and nanofluidic devices, systems, and applications |
US8877518B2 (en) | 2007-02-06 | 2014-11-04 | The Trustees Of The University Of Pennsylvania | Multiplexed nanoscale electrochemical sensors for multi-analyte detection |
WO2011084703A2 (en) | 2009-12-21 | 2011-07-14 | Advanced Liquid Logic, Inc. | Enzyme assays on a droplet actuator |
US8037903B2 (en) | 2007-04-04 | 2011-10-18 | Micropoint Bioscience, Inc. | Micromachined electrowetting microfluidic valve |
CA2682734C (en) | 2007-04-04 | 2017-11-07 | Network Biosystems, Inc. | Plastic microfluidic separation and detection platforms |
US8702976B2 (en) | 2007-04-18 | 2014-04-22 | Ondavia, Inc. | Hand-held microfluidic testing device |
ATE554859T1 (en) | 2007-05-24 | 2012-05-15 | Univ California | INTEGRATED FLUIDIC DEVICES WITH MAGNETIC SORTING |
US20100111770A1 (en) | 2007-06-07 | 2010-05-06 | Samsung Electronics Co., Ltd. | Microfluidic Chip and Method of Fabricating The Same |
ATE555836T1 (en) | 2007-06-29 | 2012-05-15 | Harvard College | DENSITY-BASED MATERIAL SEPARATION PROCESS, MONITORING SOLID-ASSISTED REACTIONS AND MEASUREMENT OF THE DENSITY OF SMALL LIQUID VOLUME AND SOLIDS |
JPWO2009008236A1 (en) | 2007-07-10 | 2010-09-02 | コニカミノルタエムジー株式会社 | Micro inspection chip liquid mixing method and inspection apparatus |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
WO2009015296A1 (en) | 2007-07-24 | 2009-01-29 | The Regents Of The University Of California | Microfabricated dropley generator |
DE102007035721B4 (en) | 2007-07-30 | 2019-02-07 | Robert Bosch Gmbh | Microvalve, method of manufacturing a microvalve and micropump |
WO2009020435A1 (en) | 2007-08-07 | 2009-02-12 | Agency For Science, Technology And Research | Integrated microfluidic device for gene synthesis |
GB2464433B (en) | 2007-08-23 | 2012-06-20 | Cynvenio Biosystems Llc | Trapping magnetic sorting system for target species |
US7892770B2 (en) * | 2007-08-24 | 2011-02-22 | Van Andel Research Institute | Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods |
EP2214823A1 (en) * | 2007-11-26 | 2010-08-11 | Atonomics A/S | Integrated separation and detection cartridge with means and method for increasing signal to noise ratio |
EP2234916A4 (en) | 2008-01-22 | 2016-08-10 | Integenx Inc | Universal sample preparation system and use in an integrated analysis system |
WO2009117611A2 (en) | 2008-03-19 | 2009-09-24 | Cynvenio Biosystems, Llc | Trapping magnetic cell sorting system |
EP2271919A1 (en) | 2008-04-16 | 2011-01-12 | Cynvenio Biosystems, Inc. | Magnetic separation system with pre and post processing modules |
US7867713B2 (en) * | 2008-04-21 | 2011-01-11 | Lawrence Livermore National Security, Llc | Polymerase chain reaction system using magnetic beads for analyzing a sample that includes nucleic acid |
US20090269504A1 (en) | 2008-04-24 | 2009-10-29 | Momentive Performance Materials Inc. | Flexible hardcoats and substrates coated therewith |
KR100960066B1 (en) | 2008-05-14 | 2010-05-31 | 삼성전자주식회사 | Microfluidic device containing lyophilized reagent therein and analysing method using the same |
US8323568B2 (en) | 2008-06-13 | 2012-12-04 | Honeywell International Inc. | Magnetic bead assisted sample conditioning system |
US8092761B2 (en) | 2008-06-20 | 2012-01-10 | Silverbrook Research Pty Ltd | Mechanically-actuated microfluidic diaphragm valve |
US7976789B2 (en) | 2008-07-22 | 2011-07-12 | The Board Of Trustees Of The University Of Illinois | Microfluidic device for preparing mixtures |
US8617488B2 (en) | 2008-08-07 | 2013-12-31 | Fluidigm Corporation | Microfluidic mixing and reaction systems for high efficiency screening |
CN102159726A (en) | 2008-09-05 | 2011-08-17 | 生命科技公司 | Methods and systems for nucleic acid sequencing validation, calibration and normalization |
RU2500478C2 (en) | 2008-10-06 | 2013-12-10 | Конинклейке Филипс Электроникс Н.В. | Micro fluid device |
JP2012504956A (en) | 2008-10-10 | 2012-03-01 | セントレ ナショナル デ ラ レシェルシェ サイエンティフィーク−ディーエーイー | Cell sorting device |
US9422409B2 (en) | 2008-10-10 | 2016-08-23 | Massachusetts Institute Of Technology | Method of hydrolytically stable bonding of elastomers to substrates |
WO2010054000A1 (en) | 2008-11-04 | 2010-05-14 | Richard Joseph | Methods, flow cells and systems for single cell analysis |
CN102341691A (en) * | 2008-12-31 | 2012-02-01 | 尹特根埃克斯有限公司 | Instrument with microfluidic chip |
EP2394152B1 (en) * | 2009-02-03 | 2019-05-01 | ANDE Corporation | Nucleic acid purification |
WO2010091406A2 (en) | 2009-02-09 | 2010-08-12 | Forensic Science Service Limited | Improvements in and relating to devices |
CN102362183B (en) | 2009-03-23 | 2014-11-05 | 皇家飞利浦电子股份有限公司 | Manipulation of magnetic particles in a biological sample |
US20100243916A1 (en) | 2009-03-30 | 2010-09-30 | Lockheed Martin Corporation | Modular optical diagnostic platform for chemical and biological target diagnosis and detection |
WO2010129937A2 (en) * | 2009-05-08 | 2010-11-11 | Life Technologies Corporation | Methods for detecting genetic variations in dna samples |
GB2473868A (en) | 2009-09-28 | 2011-03-30 | Invitrogen Dynal As | Apparatus and method of automated processing of biological samples |
EP2438154A1 (en) | 2009-06-02 | 2012-04-11 | Integenx Inc. | Fluidic devices with diaphragm valves |
AU2010257118B2 (en) | 2009-06-04 | 2014-08-28 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for DNA analysis |
KR20120031218A (en) | 2009-06-05 | 2012-03-30 | 인터젠엑스 인크. | Universal sample preparation system and use in an integrated analysis system |
WO2011003941A1 (en) | 2009-07-07 | 2011-01-13 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Device for detection of biological agents |
US20120164036A1 (en) | 2009-07-21 | 2012-06-28 | Seth Stern | Microfluidic devices and uses thereof |
US8551787B2 (en) | 2009-07-23 | 2013-10-08 | Fluidigm Corporation | Microfluidic devices and methods for binary mixing |
GB2472236A (en) | 2009-07-29 | 2011-02-02 | Iti Scotland Ltd | Apparatus for analysing microfluidic devices |
JP2013505018A (en) | 2009-09-21 | 2013-02-14 | アコーニ バイオシステムズ | Magnetic melting method and apparatus |
TWI421495B (en) | 2009-10-30 | 2014-01-01 | Univ Nat Cheng Kung | Microfluidic chip |
US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
DK2539472T3 (en) | 2010-02-26 | 2015-08-24 | Hennessy Lori | QUICK PCR FOR STR GENOTYPE DETERMINATION |
US20110240127A1 (en) | 2010-04-02 | 2011-10-06 | Integenx Inc. | Fluidic Article Fabricated In One Piece |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
WO2012097233A1 (en) | 2011-01-14 | 2012-07-19 | Integenx Inc. | Valves with hydraulic actuation system |
-
2005
- 2005-09-15 EP EP10011511A patent/EP2261650A3/en not_active Withdrawn
- 2005-09-15 US US11/229,065 patent/US20070248958A1/en not_active Abandoned
- 2005-09-15 WO PCT/US2005/033347 patent/WO2006032044A2/en active Application Filing
- 2005-09-15 CN CN2012102281091A patent/CN102759466A/en active Pending
- 2005-09-15 JP JP2007532553A patent/JP2008513022A/en not_active Withdrawn
- 2005-09-15 KR KR1020077008423A patent/KR101214780B1/en not_active IP Right Cessation
- 2005-09-15 CN CN2005800359117A patent/CN101073002B/en active Active
- 2005-09-15 EP EP05808441A patent/EP1794581A2/en not_active Withdrawn
-
2009
- 2009-10-23 US US12/605,217 patent/US8431340B2/en active Active
-
2011
- 2011-11-02 US US13/287,398 patent/US8431390B2/en active Active
-
2012
- 2012-02-06 US US13/367,326 patent/US8551714B2/en active Active
- 2012-07-02 JP JP2012148699A patent/JP2012189615A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000060362A1 (en) * | 1999-04-08 | 2000-10-12 | Chung Chang Young | Apparatus for fast preparation and analysis of nucleic acids |
US20040053290A1 (en) * | 2000-01-11 | 2004-03-18 | Terbrueggen Robert Henry | Devices and methods for biochip multiplexing |
US20040086872A1 (en) * | 2002-10-31 | 2004-05-06 | Childers Winthrop D. | Microfluidic system for analysis of nucleic acids |
US20040151629A1 (en) * | 2003-01-31 | 2004-08-05 | Grant Pease | Microfluidic device with thin-film electronic devices |
Cited By (157)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9677121B2 (en) | 2001-03-28 | 2017-06-13 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US10351901B2 (en) | 2001-03-28 | 2019-07-16 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US10619191B2 (en) | 2001-03-28 | 2020-04-14 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US10571935B2 (en) | 2001-03-28 | 2020-02-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US9290382B2 (en) | 2001-09-06 | 2016-03-22 | Rapid Micro Biosystems | Rapid detection of replicating cells |
US11499176B2 (en) | 2001-09-06 | 2022-11-15 | Rapid Micro Biosystems, Inc. | Rapid detection of replicating cells |
US9090462B2 (en) | 2001-09-06 | 2015-07-28 | Rapid Micro Biosystems, Inc. | Rapid detection of replicating cells |
US10000788B2 (en) | 2001-09-06 | 2018-06-19 | First Light Biosciences, Inc. | Rapid and sensitive detection of molecules |
US9651039B2 (en) | 2002-12-30 | 2017-05-16 | The Regents Of The University Of California | Fluid control structures in microfluidic devices |
US9644623B2 (en) | 2002-12-30 | 2017-05-09 | The Regents Of The University Of California | Fluid control structures in microfluidic devices |
US9670528B2 (en) | 2003-07-31 | 2017-06-06 | Handylab, Inc. | Processing particle-containing samples |
US11078523B2 (en) | 2003-07-31 | 2021-08-03 | Handylab, Inc. | Processing particle-containing samples |
US10731201B2 (en) | 2003-07-31 | 2020-08-04 | Handylab, Inc. | Processing particle-containing samples |
US10865437B2 (en) | 2003-07-31 | 2020-12-15 | Handylab, Inc. | Processing particle-containing samples |
US10364456B2 (en) | 2004-05-03 | 2019-07-30 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US10443088B1 (en) | 2004-05-03 | 2019-10-15 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US10604788B2 (en) | 2004-05-03 | 2020-03-31 | Handylab, Inc. | System for processing polynucleotide-containing samples |
US11441171B2 (en) | 2004-05-03 | 2022-09-13 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US10494663B1 (en) | 2004-05-03 | 2019-12-03 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US8476063B2 (en) | 2004-09-15 | 2013-07-02 | Integenx Inc. | Microfluidic devices |
US8551714B2 (en) | 2004-09-15 | 2013-10-08 | Integenx Inc. | Microfluidic devices |
US8431390B2 (en) | 2004-09-15 | 2013-04-30 | Integenx Inc. | Systems of sample processing having a macro-micro interface |
US8431340B2 (en) | 2004-09-15 | 2013-04-30 | Integenx Inc. | Methods for processing and analyzing nucleic acid samples |
US9752185B2 (en) | 2004-09-15 | 2017-09-05 | Integenx Inc. | Microfluidic devices |
US9057046B2 (en) | 2005-09-26 | 2015-06-16 | Rapid Micro Biosystems, Inc. | Cassette containing growth medium |
US10296720B2 (en) | 2005-11-30 | 2019-05-21 | Gearbox Llc | Computational systems and methods related to nutraceuticals |
US8771609B2 (en) | 2006-01-17 | 2014-07-08 | Siemens Aktiengesellschaft | Module for processing a biological sample, biochip kit, and use of the module |
GB2434205B (en) * | 2006-01-17 | 2011-04-20 | Siemens Ag | Module for preparing a biological sample, biochip-assembly and use of the module |
GB2434205A (en) * | 2006-01-17 | 2007-07-18 | Siemens Ag | Module for preparing a biological sample, biochip-assembly and use of the module |
EP1979079A4 (en) * | 2006-02-03 | 2012-11-28 | Integenx Inc | Microfluidic devices |
EP1979079A2 (en) * | 2006-02-03 | 2008-10-15 | Microchip Biotechnologies, Inc. | Microfluidic devices |
US10913061B2 (en) | 2006-03-24 | 2021-02-09 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US11085069B2 (en) | 2006-03-24 | 2021-08-10 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11141734B2 (en) | 2006-03-24 | 2021-10-12 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10695764B2 (en) | 2006-03-24 | 2020-06-30 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US11959126B2 (en) | 2006-03-24 | 2024-04-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US9080207B2 (en) | 2006-03-24 | 2015-07-14 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11142785B2 (en) | 2006-03-24 | 2021-10-12 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US10799862B2 (en) | 2006-03-24 | 2020-10-13 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US10821436B2 (en) | 2006-03-24 | 2020-11-03 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10821446B1 (en) | 2006-03-24 | 2020-11-03 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10843188B2 (en) | 2006-03-24 | 2020-11-24 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US10857535B2 (en) | 2006-03-24 | 2020-12-08 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US9040288B2 (en) | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US11666903B2 (en) | 2006-03-24 | 2023-06-06 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US9802199B2 (en) | 2006-03-24 | 2017-10-31 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
JP2010501176A (en) * | 2006-08-24 | 2010-01-21 | マイクロフルイディク システムズ インコーポレイテッド | Integrated detection device |
EP2059584A4 (en) * | 2006-08-24 | 2013-12-11 | Microfluidic Systems Inc | An integrated airborne substance collection and detection system |
EP2059584A2 (en) * | 2006-08-24 | 2009-05-20 | Microfluidic Systems Inc. | An integrated airborne substance collection and detection system |
KR101306341B1 (en) * | 2006-09-05 | 2013-09-09 | 삼성전자주식회사 | Centrifugal force-based microfluidic device for nucleic acid extraction from biological sample and microfluidic system comprising the microfluidic system |
US8841116B2 (en) * | 2006-10-25 | 2014-09-23 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated DNA analysis system using same |
US9815057B2 (en) | 2006-11-14 | 2017-11-14 | Handylab, Inc. | Microfluidic cartridge and method of making same |
US10710069B2 (en) | 2006-11-14 | 2020-07-14 | Handylab, Inc. | Microfluidic valve and method of making same |
JP2008128907A (en) * | 2006-11-22 | 2008-06-05 | Fujifilm Corp | Micro channel chip |
US10001496B2 (en) | 2007-01-29 | 2018-06-19 | Gearbox, Llc | Systems for allergen detection |
US8557518B2 (en) | 2007-02-05 | 2013-10-15 | Integenx Inc. | Microfluidic and nanofluidic devices, systems, and applications |
EP3677905A1 (en) * | 2007-04-04 | 2020-07-08 | ANDE Corporation | Integrated nucleic acid analysis |
US9494519B2 (en) | 2007-04-04 | 2016-11-15 | Netbio, Inc. | Methods for rapid multiplexed amplification of target nucleic acids |
US8425861B2 (en) | 2007-04-04 | 2013-04-23 | Netbio, Inc. | Methods for rapid multiplexed amplification of target nucleic acids |
US10065185B2 (en) | 2007-07-13 | 2018-09-04 | Handylab, Inc. | Microfluidic cartridge |
US11266987B2 (en) | 2007-07-13 | 2022-03-08 | Handylab, Inc. | Microfluidic cartridge |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
US10875022B2 (en) | 2007-07-13 | 2020-12-29 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US11060082B2 (en) | 2007-07-13 | 2021-07-13 | Handy Lab, Inc. | Polynucleotide capture materials, and systems using same |
US10234474B2 (en) | 2007-07-13 | 2019-03-19 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US10844368B2 (en) | 2007-07-13 | 2020-11-24 | Handylab, Inc. | Diagnostic apparatus to extract nucleic acids including a magnetic assembly and a heater assembly |
US11466263B2 (en) | 2007-07-13 | 2022-10-11 | Handylab, Inc. | Diagnostic apparatus to extract nucleic acids including a magnetic assembly and a heater assembly |
US10179910B2 (en) | 2007-07-13 | 2019-01-15 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US10717085B2 (en) | 2007-07-13 | 2020-07-21 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10139012B2 (en) | 2007-07-13 | 2018-11-27 | Handylab, Inc. | Integrated heater and magnetic separator |
US11549959B2 (en) | 2007-07-13 | 2023-01-10 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US10632466B1 (en) | 2007-07-13 | 2020-04-28 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10625262B2 (en) | 2007-07-13 | 2020-04-21 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10625261B2 (en) | 2007-07-13 | 2020-04-21 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10071376B2 (en) | 2007-07-13 | 2018-09-11 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10590410B2 (en) | 2007-07-13 | 2020-03-17 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US11254927B2 (en) | 2007-07-13 | 2022-02-22 | Handylab, Inc. | Polynucleotide capture materials, and systems using same |
KR101307859B1 (en) | 2007-07-19 | 2013-09-12 | 삼성전자주식회사 | Bio-chemical analyzer and method for controlling inside temperatures thereof |
EP2026074A3 (en) * | 2007-07-31 | 2009-07-01 | Samsung Electronics Co., Ltd. | Centrifugal force-based microfluidic device for nucleic acid detection and microfluidic system including the same |
EP2375256A1 (en) * | 2007-07-31 | 2011-10-12 | Samsung Electronics Co., Ltd. | Centrifugal Force-Based Microfluidic Device for Nucleic Acid Detection and Microfluidic System Including the Same |
WO2009108260A2 (en) | 2008-01-22 | 2009-09-03 | Microchip Biotechnologies, Inc. | Universal sample preparation system and use in an integrated analysis system |
US8748165B2 (en) | 2008-01-22 | 2014-06-10 | Integenx Inc. | Methods for generating short tandem repeat (STR) profiles |
US8585916B2 (en) | 2008-01-24 | 2013-11-19 | Sandia Corporation | Micropores and methods of making and using thereof |
US8815177B2 (en) | 2008-01-24 | 2014-08-26 | Sandia Corporation | Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap |
US9404913B2 (en) | 2008-01-24 | 2016-08-02 | Sandia Corporation | Micropores and methods of making and using thereof |
CN102083533B (en) * | 2008-04-10 | 2014-11-12 | 芬兰技术研究中心 | Microfluidic chip devices and their use |
CN102083533A (en) * | 2008-04-10 | 2011-06-01 | 芬兰技术研究中心 | Microfluidic chip devices and their use |
EP2276570A1 (en) * | 2008-04-10 | 2011-01-26 | Valtion Teknillinen Tutkimuskeskus | Microfluidic chip devices and their use |
EP2276570A4 (en) * | 2008-04-10 | 2012-03-28 | Valtion Teknillinen | Microfluidic chip devices and their use |
US8895292B2 (en) | 2008-04-10 | 2014-11-25 | Valtion Teknillinen Tutkimuskeskus | Microfluidic chip devices and their use |
WO2009136232A1 (en) * | 2008-05-05 | 2009-11-12 | Korkut Celal Vata | Automated, high band resolution electrophoretic system for digital visualization and method of use |
US10384203B2 (en) | 2008-09-24 | 2019-08-20 | First Light Biosciences, Inc. | Kits and devices for detecting analytes |
US11865534B2 (en) | 2008-09-24 | 2024-01-09 | First Light Diagnostics, Inc. | Imaging analyzer for testing analytes |
US11583853B2 (en) | 2008-09-24 | 2023-02-21 | First Light Diagnostics, Inc. | Kits and devices for detecting analytes |
US9643180B2 (en) | 2008-09-24 | 2017-05-09 | First Light Biosciences, Inc. | Method for detecting analytes |
US8672532B2 (en) | 2008-12-31 | 2014-03-18 | Integenx Inc. | Microfluidic methods |
US8640555B2 (en) | 2009-02-09 | 2014-02-04 | Bioaccel | Performance |
EP2393596B1 (en) * | 2009-02-09 | 2016-09-28 | Whitespace Enterprise Corporation | Microfluidic devices and methods of providing a storable sample |
EP2393596A2 (en) * | 2009-02-09 | 2011-12-14 | Forensic Science Service Ltd | Improvements in and relating to components |
WO2010091410A3 (en) * | 2009-02-09 | 2010-12-16 | Forensic Science Service Limited | Improvements in and relating to microfluidic devices for processing a sample |
WO2010091406A3 (en) * | 2009-02-09 | 2010-11-18 | Forensic Science Service Limited | Improvements in and relating to microfluidic devices for processing a sample |
WO2010091400A3 (en) * | 2009-02-09 | 2010-10-14 | Frederic Zenhausern | Improvements in and relating to microfluidic devices for processing a sample |
US8388908B2 (en) | 2009-06-02 | 2013-03-05 | Integenx Inc. | Fluidic devices with diaphragm valves |
US10538804B2 (en) | 2009-06-15 | 2020-01-21 | Ande Corporation | Methods for forensic DNA quantitation |
US11441173B2 (en) | 2009-06-15 | 2022-09-13 | Ande Corporation | Optical instruments and systems for forensic DNA quantitation |
US9550985B2 (en) | 2009-06-15 | 2017-01-24 | Netbio, Inc. | Methods for forensic DNA quantitation |
CN103331186A (en) * | 2009-07-07 | 2013-10-02 | 索尼公司 | Microfluidic device |
US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
CN103097883A (en) * | 2010-03-09 | 2013-05-08 | 网络百奥有限公司 | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
US9314795B2 (en) | 2010-03-09 | 2016-04-19 | Netbio Inc. | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
US10821445B2 (en) | 2010-03-09 | 2020-11-03 | Ande Corporation | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
US9354199B2 (en) | 2010-03-09 | 2016-05-31 | Netbio, Inc. | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
US11612894B2 (en) | 2010-03-09 | 2023-03-28 | Ande Corporation | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
US11612893B2 (en) | 2010-03-09 | 2023-03-28 | Ande Corporation | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
WO2011112746A3 (en) * | 2010-03-09 | 2012-01-12 | Netbio, Inc. | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
US8720036B2 (en) | 2010-03-09 | 2014-05-13 | Netbio, Inc. | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
US11067110B2 (en) | 2010-05-05 | 2021-07-20 | Beckman Coulter, Inc. | Device coupling for a motor |
EP2567211A2 (en) * | 2010-05-05 | 2013-03-13 | Beckman Coulter Biomedical, LLC | Diagnostic system and components |
EP2567211A4 (en) * | 2010-05-05 | 2015-04-01 | Beckman Coulter Biomedical Llc | Diagnostic system and components |
US9267618B2 (en) | 2010-05-18 | 2016-02-23 | Samsung Electronics Co., Ltd. | Microvalve device and method of manufacturing the same |
EP2388500A1 (en) * | 2010-05-18 | 2011-11-23 | Samsung Electronics Co., Ltd. | Microvalve device and method of manufacturing the same |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
US9731266B2 (en) | 2010-08-20 | 2017-08-15 | Integenx Inc. | Linear valve arrays |
US9121058B2 (en) | 2010-08-20 | 2015-09-01 | Integenx Inc. | Linear valve arrays |
US8763642B2 (en) | 2010-08-20 | 2014-07-01 | Integenx Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
US11788127B2 (en) | 2011-04-15 | 2023-10-17 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US10781482B2 (en) | 2011-04-15 | 2020-09-22 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US9765389B2 (en) | 2011-04-15 | 2017-09-19 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
USD905269S1 (en) | 2011-09-30 | 2020-12-15 | Becton, Dickinson And Company | Single piece reagent holder |
US10076754B2 (en) | 2011-09-30 | 2018-09-18 | Becton, Dickinson And Company | Unitized reagent strip |
USD831843S1 (en) | 2011-09-30 | 2018-10-23 | Becton, Dickinson And Company | Single piece reagent holder |
US11453906B2 (en) | 2011-11-04 | 2022-09-27 | Handylab, Inc. | Multiplexed diagnostic detection apparatus and methods |
US11788046B2 (en) | 2011-11-07 | 2023-10-17 | Rapid Micro Biosystems, Inc. | Cassette for sterility testing |
US9745546B2 (en) | 2011-11-07 | 2017-08-29 | Rapid Micro Biosystems, Inc. | Cassette for sterility testing |
US10801004B2 (en) | 2011-11-07 | 2020-10-13 | Rapid Micro Biosystems, Inc. | Cassette for sterility testing |
EP2604343A1 (en) * | 2011-12-15 | 2013-06-19 | Samsung Electronics Co., Ltd | Microfluidic device and method of manufacturing the same |
US10822644B2 (en) | 2012-02-03 | 2020-11-03 | Becton, Dickinson And Company | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
US10407707B2 (en) | 2012-04-16 | 2019-09-10 | Rapid Micro Biosystems, Inc. | Cell culturing device |
US11643677B2 (en) | 2012-04-16 | 2023-05-09 | Rapid Micro Biosystems, Inc. | Cell culturing device |
US9994839B2 (en) | 2013-01-16 | 2018-06-12 | The Regents Of The University Of California | Microfluidic devices to extract, concentrate and isolate molecules |
CN103627806A (en) * | 2013-12-03 | 2014-03-12 | 武汉大学 | Method for developing SSR marks based on magnetic field controllable micro-fluidic chip |
US10392651B2 (en) | 2014-02-28 | 2019-08-27 | Ge Healthcare Uk Limited | Processed biological sample storage |
WO2015128259A1 (en) * | 2014-02-28 | 2015-09-03 | Ge Healthcare Uk Limited | Improvements in and relating to processed biological sample storage |
US11891650B2 (en) | 2014-05-21 | 2024-02-06 | IntegenX, Inc. | Fluid cartridge with valve mechanism |
US10961561B2 (en) | 2014-05-21 | 2021-03-30 | IntegenX, Inc. | Fluidic cartridge with valve mechanism |
US11482052B2 (en) | 2014-10-22 | 2022-10-25 | IntegenX, Inc. | Systems and methods for biometric data collections |
US10210410B2 (en) | 2014-10-22 | 2019-02-19 | Integenx Inc. | Systems and methods for biometric data collections |
US10213783B2 (en) | 2015-07-17 | 2019-02-26 | Delta Electronics, Inc. | Nucleic acid extracting device |
US11491482B2 (en) | 2015-07-17 | 2022-11-08 | Delta Electronics, Inc. | Method for extracting nucleic acid and extraction cassette thereof |
US11207681B2 (en) | 2015-07-17 | 2021-12-28 | Delta Electronics, Inc. | Method for extracting nucleic acid and extraction cassette thereof |
US10648975B2 (en) | 2017-07-03 | 2020-05-12 | Lansion Biotechnology Co., Ltd. | Single channel chemiluminescent micro-fluidic chip and detection method thereof |
US20210276012A1 (en) * | 2018-07-10 | 2021-09-09 | Tdk Corporation | Device and method for detecting nucleic acids by isothermal amplification technique |
US11733258B2 (en) | 2019-12-10 | 2023-08-22 | Industrial Technology Research Institute | Nucleic acid extracting device |
EP3842134A1 (en) * | 2019-12-10 | 2021-06-30 | Industrial Technology Research Institute | Nucleic acid extracting device |
WO2022029299A3 (en) * | 2020-08-06 | 2022-04-07 | Thermo Fisher Scientific Geneart Gmbh | Laboratory equipment, corresponding uses and methods |
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CN101073002B (en) | 2012-08-08 |
JP2008513022A (en) | 2008-05-01 |
US20100068723A1 (en) | 2010-03-18 |
US20120088249A1 (en) | 2012-04-12 |
US20070248958A1 (en) | 2007-10-25 |
US8431390B2 (en) | 2013-04-30 |
JP2012189615A (en) | 2012-10-04 |
US20130029338A1 (en) | 2013-01-31 |
US8431340B2 (en) | 2013-04-30 |
KR101214780B1 (en) | 2012-12-21 |
KR20070063542A (en) | 2007-06-19 |
US8551714B2 (en) | 2013-10-08 |
EP1794581A2 (en) | 2007-06-13 |
EP2261650A2 (en) | 2010-12-15 |
CN101073002A (en) | 2007-11-14 |
EP2261650A3 (en) | 2011-07-06 |
CN102759466A (en) | 2012-10-31 |
WO2006032044A3 (en) | 2007-01-25 |
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