WO2005055837A1 - Apparatus for pressing a blood vessel - Google Patents

Apparatus for pressing a blood vessel Download PDF

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Publication number
WO2005055837A1
WO2005055837A1 PCT/KR2004/003275 KR2004003275W WO2005055837A1 WO 2005055837 A1 WO2005055837 A1 WO 2005055837A1 KR 2004003275 W KR2004003275 W KR 2004003275W WO 2005055837 A1 WO2005055837 A1 WO 2005055837A1
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WO
WIPO (PCT)
Prior art keywords
tube
penefration
pins
blood vessel
tissue
Prior art date
Application number
PCT/KR2004/003275
Other languages
French (fr)
Inventor
Hyun-Chul Rhim
Eui-Duck Jin
Young-Sun Kim
Original Assignee
Hyun-Chul Rhim
Eui-Duck Jin
Young-Sun Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyun-Chul Rhim, Eui-Duck Jin, Young-Sun Kim filed Critical Hyun-Chul Rhim
Publication of WO2005055837A1 publication Critical patent/WO2005055837A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/132Tourniquets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12009Implements for ligaturing other than by clamps or clips, e.g. using a loop with a slip knot

Definitions

  • surgical operations are procedures in which skin, mucosa, and/or other tissues are sheared, incised, or manipulated using medical equipment to cure diseases.
  • the surgical operations are mainly divided into invasive operation and noninvasive operation.
  • Invasive operations includes laparotomy in which the abdomen is incised, and is disadvantageous in that patient recovery time after the operation is long, the probability of sequelae or complications is increased, and pain felt by the patient after the operation is increased.
  • invasive operations require general anesthesia. Accordingly, noninvasive operations, which do not require general anesthesia, reduce damages to muscles, nerves, arthroses, and bones, and shorten the patent recovery time after the operation, are increasingly performed.
  • a blood vessel is occasionally pressed to block blood flow.
  • One method for eliminating a tumor is hyperthermia, in which cancer tissue is killed by increasing the temperature of the tumor.
  • the hyperthermia is disadvantageous in that blood flowing around the cancer tissue is cooled, thereby causing a difficulty in having sufficient therapeutic efficiency.
  • an apparatus for pressing a blood vessel comprising: a hand lever; a penetration tube, one end of which is connected to the hand lever and the other end of which is sha ⁇ ened so as to be inserted into a tissue of the human body; pins made of an elastic material, movably installed in the penetration tube, having arc shapes protruded from the other end of the penetration tube in the direction perpendicular to an inserted direction of the penetration tube under the condition that the penetration tube is inserted into the tissue, and serving to press the blood vessel by pulling or pushing the blood vessel for blocking blood flow; and an actuator moved in the same direction of the longitudinal direction of the penetration tube for inserting the pins into the penetration tube or protruding the pins from the penetration tube.
  • the apparatus may ftirther comprise a holder installed such that the holder is movable along the outer surface of the penetration tube, and contacting a skin of the tissue and fixed to the outer surface of the penetration tube for maintaining the pressed state of the blood vessel in the case that the pins pull the blood vessel to press the blood vessel.
  • the apparatus may further comprise electrodes installed in the penetration tube such that the electrodes are moved by the actuator, having arc shapes protruded from the other end of the penefration tube in the direction pe ⁇ endicular to the inserted direction of the penetration tube when the penetration tube presses the blood vessel, and serving to heat a lesion portion of the tissue; and a power unit for supplying high-frequency power to the electrodes.
  • the pins may be made of a shape memory alloy, such as a nickel- titanium (Ni-Ti) alloy, and be coated with an insulating material, such as Teflon.
  • the apparatus of the present invention presses the blood vessel using the penefration tube without incising the tissue of the human body, thereby being capable of blocking blood flow. Accordingly, in the case that a lesion portion of a tumor is treated by hyperthermia, the apparatus maximizes therapeutic efficiency.
  • FIG. 1 is a schematic side view of an apparatus for pressing a blood vessel in accordance with a first preferred embodiment of the present invention
  • FIG.2 is a schematic front view of the apparatus shown in FIG. 1
  • FIG. 3 is a schematic side view of the apparatus shown in FIG. 1 in a state in which pins are protruded
  • FIG.4 is a schematic front view of the apparatus shown in FIG. 3
  • FIG. 5 is a schematic view of the apparatus shown in FIG. 3, which is fixed to a tissue of the human body;
  • FIG. 1 is a schematic side view of an apparatus for pressing a blood vessel in accordance with a first preferred embodiment of the present invention
  • FIG.2 is a schematic front view of the apparatus shown in FIG. 1
  • FIG. 3 is a schematic side view of the apparatus shown in FIG. 1 in a state in which pins are protruded
  • FIG.4 is a schematic front view of the apparatus shown in FIG. 3
  • FIG. 5 is a schematic view of the apparatus shown in FIG. 3, which is
  • FIG. 6 is a schematic side view of an apparatus for pressing a blood vessel in accordance with a second preferred embodiment of the present invention
  • FIG.7 is a schematic front view of the apparatus shown in FIG. 6
  • FIG. 8 is a schematic rear view of the apparatus shown in FIG.6
  • FIG. 9 is a schematic side view of the apparatus shown in FIG. 6 in a state in which pins and electrodes are protruded
  • FIG. 10 is a schematic front view of the apparatus shown in FIG. 6.
  • FIG. 1 is a schematic side view of an apparatus for pressing a blood vessel in accordance with a first preferred embodiment of the present invention
  • FIG. 2 is a schematic front view of the apparatus shown in FIG. 1.
  • FIG. 3 is a schematic side view of the apparatus shown in FIG. 1 in a state in which pins are protruded
  • FIG.4 is a schematic front view of the apparatus shown in FIG.3.
  • FIG. 5 is a schematic view of the apparatus shown in FIG. 3, which is fixed to a tissue of the human body.
  • the apparatus 100 for pressing a blood vessel in accordance with the first preferred embodiment of the present invention comprises a hand lever 110, a penefration tube 120, one end of which is connected to the hand lever 110 and the other end of which is sha ⁇ ened so as to be inserted into a tissue 10 of the human body, pins 130 made of an elastic material, movably installed in the penefration tube 120, having arc shapes protruded from the other end of the penefration tube 120 in the direction pe ⁇ endicular to an inserted direction of the penetration tube 120 under the condition that the penefration tube 120 is inserted into the tissue 10 of the human body, and serving to press a blood vessel 20 of the tissue 10 by pulling or pushing the blood vessel 20 for blocking blood flow, an actuator 150 moved in the same direction of the longitudinal direction of the penefration tube 120 for inserting the pins 130 into the penefration tube 120 or protruding the pins 130 from the penefration tube 120, and a holder 160 installed such that the holder 160 is
  • the hand lever 110 is made of a plastic or metal material, and has a hollowed cylindrical structure so as to be conveniently gripped. Although not shown in the drawings, preferably, one end of the hand lever 110 is opened by a cap.
  • the penefration tube 120 is made of a stainless steel (SUS) material, and has an elongated narrow tubular shape. One end of the penefration tube 120 is connected to the hand lever 120. The other end of the penefration tube 120 is slantingly sha ⁇ ened so that the other end of the penetration tube 120 is easily inserted into the tissue 10 of the human body.
  • the proper length of the penetration tube 120 is one selected from the group consisting of 17.5cm, 25.0cm, and 30.0cm, but is not limited thereto.
  • the substantial length of the penetration tube 120 depends on selection of surgical methods, such as the insertion into an abdominal cavity and the penetration of a skin, the position of the blood vessel 20 to be pressed by the penefration tube 120, the distance from the skin to the blood vessel 20, and the accessibility to the blood vessel 20.
  • the penefration tube 120 has a diameter sufficient to contain a plurality of the pins 130, which will be described later.
  • a scale is drawn on the outer surface of the penefration tube 120. Through the scale of the penefration tube 120, a user can check the length of the penefration tube 120, which is inserted into the tissue 10 of the human body.
  • the surface of the penefration tube 120 is coated with an insulating material.
  • the apparatus 100 is used together with a high-frequency treating apparatus using a high frequency wave for heating a lesion portion.
  • the surface of the penefration tube 120 is coated with the insulating material, thereby preventing the penefration tube 120 of the apparatus of the present invention and an electrode of the high- frequency treating apparatus from being electrically connected.
  • various substances may be used as the insulating material, preferably, Teflon is used as the insulating material. Teflon has excellent insulating capacity, abrasion resistance and chemical resistance, thereby being capable of long tenn use.
  • the pins 130 serve to press the blood vessel 20 in the tissue 10 of the human body, thereby blocking the blood flow.
  • the pins 130 are installed in the penefration tube 120 such that the pins 130 are movable along the penefration tube 120. As shown in FIG. 3, the pins 130 are protruded from the other end of the penefration tube 120 under the condition that the penefration tube 120 is inserted into the tissue 10 of the human body. In the case that the pins 130 are located in the penetration tube 120, the pins 130 have rectilinear shapes due to the shape of the penefration tube 120, and in the case that the pins 130 are protruded from the other end of the penefration tube 120, the pins 130 have arc shapes in the direction pe ⁇ endicular to the direction of the penefration tube 120 inserted into the tissue 10 of the human body.
  • the pins 130 are made of a shape memory alloy having an arc shape.
  • the inner surface of the penetration tube 120 serves as a guide, thereby maintaining the rectilinear shapes of the pins 130.
  • the pins 130 are protruded from the other end of the penefration tube 120, the pins 130 are returned to their original shapes, i.e., the arc shapes, in the direction pe ⁇ endicular to the inserted direction of the penefration tube 120.
  • the pins 130 are made of the shape memory alloy containing one selected from the group consisting of a nickel-titanium (Ni-Ti) alloy, as it is called 'nitinol', a nickel-titanium- copper (Ni-Ti-Cu) alloy, a nickel-titanium-cobalt (Ni-Ti-Co) alloy, and a copper-zinc- aluminum (Cu-Zn-Al) alloy.
  • the shape memory alloy utilizes the same phenomenon as martensite transformation, which is a kind of phase transformation in a solid state of metal. All of alloys, which exhibit the thermoelastic martensite transformation, have a shape memory property.
  • the shape memory alloy may utilize the same phenomenon as austenite transformation, which is a kind of phase transformation in a solid state of metal.
  • austenite transformation which is a kind of phase transformation in a solid state of metal.
  • the shape memory alloys have an allowable strength (kgtfm ⁇ ) of 196 (Ni-Ti alloy), 294 (Ni-Ti-Co alloy), and 68-98 (Ni-Ti-Cu alloy), and an elastic modulus (kgffi ⁇ ) of 7,845-9,800 (Ni-Ti alloy), 9,800-13,730 (Ni-Ti- Co alloy), and 0-4,900 (Ni-Ti-Cu alloy), according to kinds of the alloys.
  • the shape memory alloys have an allowable strength (kgffimrf) of 390-785 (Ni-Ti alloy), 490-980 (Ni-Ti-Co alloy), and 390-785 (Ni-Ti- Cu alloy), and an elastic modulus (kgfflmrf) of 17,650-21,575 (Ni-Ti alloy), 25,500-28,440 (Ni-Ti-Co alloy), and 19,615-27,460 (Ni-Ti-Cu alloy), according to lands of the alloys.
  • the protruded length of the pins 130 is 3cm.
  • the pins 130 must have enough strength to withstand force applied to block the blood flow of the blood vessel 20.
  • the number of the pins 130 may be various, but is preferably four.
  • the pins 130 are coated with an insulating material.
  • the apparatus 100 is used together with a high-frequency treating apparatus using a high frequency wave for heating a lesion portion. Since the pins 130 are coated with the insulating material, the pins 130 of the apparatus of the present invention inserted into the tissue 10 of the human body and the electrode of the high- frequency treating apparatus are prevented from being electrically connected.
  • various materials may be used as the insulating material, preferably, Teflon is used as the insulating material.
  • the hand lever 110 is pushed in the inserted direction of the penefration tube 120 so that the pins 130 press the blood vessel 20.
  • the pins 130 are disposed such that the pins 130 are radially spaced from one another by the same interval with respect to the penefration tube 120.
  • the hand lever 110 is pulled in the direction opposite to the inserted direction of the penefration tube 120 so that the pins 130 press the blood vessel 20.
  • the number of the pins 130 is one, or in the case that the number of the pins 130 is several, the pins 130 turn in the same direction.
  • the pins 130 are radially spaced from one another by the same interval, when the hand lever 110 is pulled in the direction opposite to the inserted direction of the penetration tube 120, the arc-shaped pins 130 damage tissues distant from the blood vessel 20 as well as tissues around the blood vessel 20.
  • one pin 130 may be provided or plural pins turning in the same direction may be provided, thereby minimizing damage to healthy tissues distant from the blood vessel 20.
  • the above two methods are selectively used in consideration of positions of the tissue 10 and the blood vessel 20 of the human body.
  • the actuator 150 is inserted into the hand lever 110 through the opened end of the hand laver 110 having a hollowed cylindrical structure, and rectilinearly reciprocates along the inserted direction of the penefration tube 120. That is, the actuator 150 performs piston movement inside the hand lever 110.
  • the actuator 150 is divided into one portion, which is inserted into the hand lever 110, and the other portion, which is protruded from the hand lever 110. The moving distance of the actuator 150 is limited by an inner space of the hand lever 110.
  • the portion of the actuator 150 which is protruded from the hand lever 110, has a structure having an oval-shaped section, the long radius of which is larger than the radius of the hand lever 110 so that the protruded portion of the actuator 150 is easily gripped by a surgeon's hand. Accordingly, the actuator 150 easily performs the piston movement. Since the actuator 150 is connected to the pins 130, the actuator 150 is inserted into or protruded from the penetration tube 120 according to the rectilinear reciprocation. Accordingly, the size of the inner space of the hand lever 110 is adjusted, thereby controlling the protruded length of the pins 130.
  • the holder 160 is installed on the outer surface of the penefration tube 120 such that the holder 160 slides along the outer surface of the penefration tube 120.
  • the holder 160 contacts the skin of the tissue 10 of the human body and is fixed to the outer surface of the penetration tube 120, thus allowing the blood vessel 20 to maintain the pressed state. Since the holder 160 fixes the apparatus 100 as well as maintains the pressed state of the blood vessel 20, a surgeon's hand, which has fixed the apparatus 100, becomes free. Accordingly, the surgeon can perform an operation using both hands. Thereby, the surgeon can perform the operation using both hands, thus being capable of more precisely perforating the operation and perforating another operation. With the apparatus 100 of the present invention, the surgeon presses the blood vessel 20 to block the blood flow without incising the tissue 10 of a patient. FIG.
  • FIG. 6 is a schematic side view of an apparatus for pressing a blood vessel in accordance with a second preferred embodiment of the present invention
  • FIG. 7 is a schematic front view ofthe apparatus shown in FIG. 6
  • FIG. 8 is a schematic rear view ofthe apparatus shown in FIG.6
  • FIG. 9 is a schematic side view ofthe apparatus shown in FIG. 6 in a state in which pins and electrodes are protruded
  • FIG. 10 is a schematic front view of the apparatus shown in FIG.6.
  • the apparatus 200 for pressing a blood vessel in accordance with the second preferred embodiment ofthe present invention comprises a hand lever 210, a penefration tube 220, one end of which is connected to the hand lever 210 and the other end of which is sha ⁇ ened so as to be inserted into a tissue 10 of the human body, pins 230 made of an elastic material, movably installed in the penefration tube 220, having arc shapes protruded from the other end of the penetration tube 220 in the direction pe ⁇ endicular to an inserted direction ofthe penefration tube 220 under the condition that the penefration tube 220 is inserted into the tissue 10 ofthe human body, and serving to press a blood vessel 20 ofthe tissue 10 by pulling or pushing the blood vessel 20 for blocking blood flow, elecfrodes 240 installed in the penefration tube 220 movably together with the pins 230, having arc shapes protruded from the other end of the penetration tube 220 in the direction pe ⁇ endicular to the inserted direction of
  • parts ofthe apparatus 200 in accordance with the second embodiment are substantially the same as those of he apparatus 100 in accordance with the first embodiment except for the elecfrodes 240, the actuator 250, and the power unit 270.
  • the pins 230 ofthe apparatus 200 ofthe second embodiment are coated with an insulating material. Since the pins 230 are coated with the insulating material, the pins 230 and the elecfrodes 240 are prevented from being electrically connected.
  • Teflon is used as the insulating material.
  • the elecfrodes 240 serve to heat the lesion portion of the tissue 10 of the human body, are movably installed in the penefration tube 220 simultaneously with or independently from the pins 230, and are protruded from the other end of the penetration tube 220 under the condition that the penetration tube 220 is inserted into the tissue of the human body.
  • the inner surface of the penetration tube 220 serves as a guide, thereby maintaining the rectilinear shapes ofthe electrodes 240.
  • the electrodes 240 are protruded from the other end of the penefration tube 220, the electrodes 240 are returned to their original shapes, i.e., the arc shapes, in the direction pe ⁇ endicular to the inserted direction of the penetration tube 220.
  • the elecfrodes 240 are made ofthe shape memory alloy containing one selected from the group consisting of a nickel-titanium (Ni-Ti) alloy, a nickel-titanium-copper (Ni-Ti-Cu) alloy, a nickel-titanium-cobalt (Ni-Ti-Co) alloy, and a copper-zinc-aluminum (Cu-Zn-Al) alloy.
  • the material or property ofthe elecfrodes 240 are the same as those ofthe pins 130 ofthe apparatus 100 ofthe first embodiment, and a detailed description thereof will thus be omitted.
  • the protruded length ofthe electrodes 240 may be various according to the position or size ofthe lesion portion, and, preferably, is longer than the protruded length ofthe pins 230.
  • the number ofthe elecfrodes 240 may be various, and, preferably, is two.
  • the electrodes 240 in the drawings are made of a shape memory alloy having an arc shape, the elecfrodes 240 may be made of metal having a rectilinear shape.
  • a sensor for measuring temperature may be provided on one end ofthe elecfrodes 240. The sensor detects the temperature ofthe lesion portion ofthe tissue 10 heated by the electrodes 240.
  • the power unit 270 supplies power to the elecfrodes 240 for heating the lesion portion ofthe tissue 10.
  • a high-frequency wave is mainly used as the power ofthe power unit 270.
  • a microwave or a laser may be used as the power ofthe power unit 270.
  • the actuator 250 ofthe apparatus 200 ofthe second embodiment is similar to the actuator 150 ofthe apparatus 100 ofthe first embodiment, but differs from the actuator 150 ofthe apparatus 100 ofthe first embodiment in that a power connection unit 280 connected to the elecfrodes 240 and the power unit 270 is provided on the end of the actuator 250 protruded from the hand lever 210.
  • the power connection unit 280 is connected to the power unit 270 through a cable extended from the power unit 270.
  • the actuator 250 has an integrated structure.
  • the actuator 250 includes one portion connected to the pins 230 for protruding the pins 230 from the penetration tube 220 or inserting the pins 230 into the penetration tube 220, and the other portion connected to the elecfrodes 240 for protruding the elecfrodes 240 from the penetration tube 220 or inserting the electrodes 240 into the penefration tube 220.
  • the power connection unit 280 is connected to the portion ofthe actuator 250 connected to the electrodes 240.
  • the apparatus 200 of the second embodiment simultaneously comprises the pins 230 for pressing the blood vessel 20 to block the blood flow, and the electrodes 240 for heating the lesion portion ofthe tissue 10. Accordingly, the apparatus 200 can heat larger dimensions ofthe lesion portion ofthe tissue 10 at a higher temperature using the electrodes
  • the exothennic therapy varies permeability or fluidity of a cellular membrane (or a nuclear membrane), divides lysosome of cytoplasm for causing discharge of digestive enzyme, thermally damages protein influencing cellular respiration and synthesis of DNA or RNA, and stimulates the immune system.
  • High-frequency alternating current generated due to hindrance of a high-frequency wave, flows from the elecfrodes 240 to a target tissue of a cell. Since ions are apt to comply with the change ofthe direction ofthe alternating current, agitation of ions occurs in an end cell tissue region close to the elecfrodes 240. Since the agitation ofthe ions generates heat due to friction, the tissue 10 around the elecfrodes 240 rather than the electrodes 240 is a main factor for generating heat. The generation of heat by the tissue 10 occurs when the current passes through electrical resistance supplied from the tissue 10. Here, the higher the resistance is, the higher the heat is.
  • the present invention provides an apparatus, which presses a blood vessel to block blood flow using a penefration tube and pins without incising a tissue of a patient. Further, the apparatus of the present invention heats a lesion portion of the tissue using elecfrodes, thereby treating the lesion portion. Since the blood flow ofthe blood vessel is blocked, the apparatus ofthe present invention increases heating effects when the lesion portion ofthe tissue is heated, and needs not incise the tissue, thereby assisting recovery of patient' s health after operation.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
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  • Surgical Instruments (AREA)

Abstract

Disclosed is an apparatus for pressing a blood vessel to block blood flow. A penetration tube, which is inserted into a tissue of the human body, is connected to a hand lever. Pins made of an elastic material, having arc shapes protruded from the penetration tube under the condition that the penetration tube is inserted into the tissue, are installed in the penetration tube. An actuator is connected to the hand lever, and causes the pins to be inserted into or protruded from the penetration tube. Accordingly, the apparatus presses the blood vessel to block the blood flow without incising a patient’s tissue. The apparatus blocks the blood flow, thereby increasing heating effects when the apparatus heats a lesion portion of the tissue. Further, the apparatus need not incise the tissue, thereby assisting recovery of patient’s health after operation.

Description

APPARATUS FOR PRESSING A BLOOD VESSEL BACKGROUND OF THE INVENTION Field of the Invention
The present invention relates to an apparatus for pressing a blood vessel, which is used in a surgical operation, and more particularly to an apparatus for pressing a blood vessel to block blood flow, thereby providing convenience in a surgical operation.
Description of the Related Art
As well known to those skilled in the art, surgical operations are procedures in which skin, mucosa, and/or other tissues are sheared, incised, or manipulated using medical equipment to cure diseases. The surgical operations are mainly divided into invasive operation and noninvasive operation. Invasive operations includes laparotomy in which the abdomen is incised, and is disadvantageous in that patient recovery time after the operation is long, the probability of sequelae or complications is increased, and pain felt by the patient after the operation is increased. Further, invasive operations require general anesthesia. Accordingly, noninvasive operations, which do not require general anesthesia, reduce damages to muscles, nerves, arthroses, and bones, and shorten the patent recovery time after the operation, are increasingly performed. In order to prevent internal bleeding during the noninvasive operation or increase effects of the noninvasive operation, a blood vessel is occasionally pressed to block blood flow. One method for eliminating a tumor is hyperthermia, in which cancer tissue is killed by increasing the temperature of the tumor. However, the hyperthermia is disadvantageous in that blood flowing around the cancer tissue is cooled, thereby causing a difficulty in having sufficient therapeutic efficiency..
SUMMARY OF THE INVENTION
Therefore, the present invention has been made in view of the above problems, and it is an object of the present invention to provide an apparatus for pressing a blood vessel to block blood flow in a noninvasive surgical operation, thereby increasing therapeutic efficiency. In accordance with the present invention, the above and other objects can be accomplished by the provision of an apparatus for pressing a blood vessel comprising: a hand lever; a penetration tube, one end of which is connected to the hand lever and the other end of which is shaφened so as to be inserted into a tissue of the human body; pins made of an elastic material, movably installed in the penetration tube, having arc shapes protruded from the other end of the penetration tube in the direction perpendicular to an inserted direction of the penetration tube under the condition that the penetration tube is inserted into the tissue, and serving to press the blood vessel by pulling or pushing the blood vessel for blocking blood flow; and an actuator moved in the same direction of the longitudinal direction of the penetration tube for inserting the pins into the penetration tube or protruding the pins from the penetration tube. Preferably, the apparatus may ftirther comprise a holder installed such that the holder is movable along the outer surface of the penetration tube, and contacting a skin of the tissue and fixed to the outer surface of the penetration tube for maintaining the pressed state of the blood vessel in the case that the pins pull the blood vessel to press the blood vessel. More preferably, the apparatus may further comprise electrodes installed in the penetration tube such that the electrodes are moved by the actuator, having arc shapes protruded from the other end of the penefration tube in the direction peφendicular to the inserted direction of the penetration tube when the penetration tube presses the blood vessel, and serving to heat a lesion portion of the tissue; and a power unit for supplying high-frequency power to the electrodes. Preferably, the pins may be made of a shape memory alloy, such as a nickel- titanium (Ni-Ti) alloy, and be coated with an insulating material, such as Teflon. The apparatus of the present invention presses the blood vessel using the penefration tube without incising the tissue of the human body, thereby being capable of blocking blood flow. Accordingly, in the case that a lesion portion of a tumor is treated by hyperthermia, the apparatus maximizes therapeutic efficiency.
BRIEF DESCRIPTION OF THE DRAWINGS
The above and other objects, features and other advantages of the present invention will be more clearly understood from the following detailed description taken in conjunction with the accompanying drawings, in which: FIG. 1 is a schematic side view of an apparatus for pressing a blood vessel in accordance with a first preferred embodiment of the present invention; FIG.2 is a schematic front view of the apparatus shown in FIG. 1 ; FIG. 3 is a schematic side view of the apparatus shown in FIG. 1 in a state in which pins are protruded; FIG.4 is a schematic front view of the apparatus shown in FIG. 3; FIG. 5 is a schematic view of the apparatus shown in FIG. 3, which is fixed to a tissue of the human body; FIG. 6 is a schematic side view of an apparatus for pressing a blood vessel in accordance with a second preferred embodiment of the present invention; FIG.7 is a schematic front view of the apparatus shown in FIG. 6; FIG. 8 is a schematic rear view of the apparatus shown in FIG.6; FIG. 9 is a schematic side view of the apparatus shown in FIG. 6 in a state in which pins and electrodes are protruded; and FIG. 10 is a schematic front view of the apparatus shown in FIG. 6.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
Now, preferred embodiments of the present invention will be described in detail with reference to the annexed drawings. FIG. 1 is a schematic side view of an apparatus for pressing a blood vessel in accordance with a first preferred embodiment of the present invention, and FIG. 2 is a schematic front view of the apparatus shown in FIG. 1. FIG. 3 is a schematic side view of the apparatus shown in FIG. 1 in a state in which pins are protruded, and FIG.4 is a schematic front view of the apparatus shown in FIG.3. FIG. 5 is a schematic view of the apparatus shown in FIG. 3, which is fixed to a tissue of the human body. With reference to FIGS. 1 to 5, the apparatus 100 for pressing a blood vessel in accordance with the first preferred embodiment of the present invention comprises a hand lever 110, a penefration tube 120, one end of which is connected to the hand lever 110 and the other end of which is shaφened so as to be inserted into a tissue 10 of the human body, pins 130 made of an elastic material, movably installed in the penefration tube 120, having arc shapes protruded from the other end of the penefration tube 120 in the direction peφendicular to an inserted direction of the penetration tube 120 under the condition that the penefration tube 120 is inserted into the tissue 10 of the human body, and serving to press a blood vessel 20 of the tissue 10 by pulling or pushing the blood vessel 20 for blocking blood flow, an actuator 150 moved in the same direction of the longitudinal direction of the penefration tube 120 for inserting the pins 130 into the penefration tube 120 or protruding the pins 130 from the penefration tube 120, and a holder 160 installed such that the holder 160 is movable along the outer surface of the penetration tube 120, and contacting a skin of the tissue 10 and fixed to the outer surface of the penetration tube 120 for maintaining the pressed state of the blood vessel 20 in the case that the pins 130 pull the blood vessel 20. The hand lever 110 is made of a plastic or metal material, and has a hollowed cylindrical structure so as to be conveniently gripped. Although not shown in the drawings, preferably, one end of the hand lever 110 is opened by a cap. The penefration tube 120 is made of a stainless steel (SUS) material, and has an elongated narrow tubular shape. One end of the penefration tube 120 is connected to the hand lever 120. The other end of the penefration tube 120 is slantingly shaφened so that the other end of the penetration tube 120 is easily inserted into the tissue 10 of the human body. The proper length of the penetration tube 120 is one selected from the group consisting of 17.5cm, 25.0cm, and 30.0cm, but is not limited thereto. The substantial length of the penetration tube 120 depends on selection of surgical methods, such as the insertion into an abdominal cavity and the penetration of a skin, the position of the blood vessel 20 to be pressed by the penefration tube 120, the distance from the skin to the blood vessel 20, and the accessibility to the blood vessel 20. The penefration tube 120 has a diameter sufficient to contain a plurality of the pins 130, which will be described later. A scale is drawn on the outer surface of the penefration tube 120. Through the scale of the penefration tube 120, a user can check the length of the penefration tube 120, which is inserted into the tissue 10 of the human body. Preferably, the surface of the penefration tube 120 is coated with an insulating material. Generally, the apparatus 100 is used together with a high-frequency treating apparatus using a high frequency wave for heating a lesion portion. The surface of the penefration tube 120 is coated with the insulating material, thereby preventing the penefration tube 120 of the apparatus of the present invention and an electrode of the high- frequency treating apparatus from being electrically connected. Although various substances may be used as the insulating material, preferably, Teflon is used as the insulating material. Teflon has excellent insulating capacity, abrasion resistance and chemical resistance, thereby being capable of long tenn use. The pins 130 serve to press the blood vessel 20 in the tissue 10 of the human body, thereby blocking the blood flow. The pins 130 are installed in the penefration tube 120 such that the pins 130 are movable along the penefration tube 120. As shown in FIG. 3, the pins 130 are protruded from the other end of the penefration tube 120 under the condition that the penefration tube 120 is inserted into the tissue 10 of the human body. In the case that the pins 130 are located in the penetration tube 120, the pins 130 have rectilinear shapes due to the shape of the penefration tube 120, and in the case that the pins 130 are protruded from the other end of the penefration tube 120, the pins 130 have arc shapes in the direction peφendicular to the direction of the penefration tube 120 inserted into the tissue 10 of the human body. In order to foπn the above-varied shapes, the pins 130 are made of a shape memory alloy having an arc shape. In the case that the pins 130, which is made of a shape memory alloy, are located in the penefration tube 120, the inner surface of the penetration tube 120 serves as a guide, thereby maintaining the rectilinear shapes of the pins 130. However, in the case that the pins 130 are protruded from the other end of the penefration tube 120, the pins 130 are returned to their original shapes, i.e., the arc shapes, in the direction peφendicular to the inserted direction of the penefration tube 120. The pins 130 are made of the shape memory alloy containing one selected from the group consisting of a nickel-titanium (Ni-Ti) alloy, as it is called 'nitinol', a nickel-titanium- copper (Ni-Ti-Cu) alloy, a nickel-titanium-cobalt (Ni-Ti-Co) alloy, and a copper-zinc- aluminum (Cu-Zn-Al) alloy. The shape memory alloy utilizes the same phenomenon as martensite transformation, which is a kind of phase transformation in a solid state of metal. All of alloys, which exhibit the thermoelastic martensite transformation, have a shape memory property. Further, the shape memory alloy may utilize the same phenomenon as austenite transformation, which is a kind of phase transformation in a solid state of metal. In case of the martensite transformation, the shape memory alloys have an allowable strength (kgtfmπ ) of 196 (Ni-Ti alloy), 294 (Ni-Ti-Co alloy), and 68-98 (Ni-Ti-Cu alloy), and an elastic modulus (kgffiππ ) of 7,845-9,800 (Ni-Ti alloy), 9,800-13,730 (Ni-Ti- Co alloy), and 0-4,900 (Ni-Ti-Cu alloy), according to kinds of the alloys. In case of the austenite transformation, the shape memory alloys have an allowable strength (kgffimrf) of 390-785 (Ni-Ti alloy), 490-980 (Ni-Ti-Co alloy), and 390-785 (Ni-Ti- Cu alloy), and an elastic modulus (kgfflmrf) of 17,650-21,575 (Ni-Ti alloy), 25,500-28,440 (Ni-Ti-Co alloy), and 19,615-27,460 (Ni-Ti-Cu alloy), according to lands of the alloys. Preferably, the protruded length of the pins 130 is 3cm. The pins 130 must have enough strength to withstand force applied to block the blood flow of the blood vessel 20. The number of the pins 130 may be various, but is preferably four. In the same manner as the penefration tube 120, the pins 130 are coated with an insulating material. In most cases, the apparatus 100 is used together with a high-frequency treating apparatus using a high frequency wave for heating a lesion portion. Since the pins 130 are coated with the insulating material, the pins 130 of the apparatus of the present invention inserted into the tissue 10 of the human body and the electrode of the high- frequency treating apparatus are prevented from being electrically connected. Although various materials may be used as the insulating material, preferably, Teflon is used as the insulating material. The pins 130 protruded from the other end of the penetration tube 120 press the blood vessel 20 in the tissue 10 of the human body, thereby blocking the blood flow. There are several methods for pressing the blood vessel 20 by means of the pins 130. As one method, the hand lever 110 is pushed in the inserted direction of the penefration tube 120 so that the pins 130 press the blood vessel 20. In this method, as shown in the drawings, the pins 130 are disposed such that the pins 130 are radially spaced from one another by the same interval with respect to the penefration tube 120. Further, as another method, as shown in FIG. 5, the hand lever 110 is pulled in the direction opposite to the inserted direction of the penefration tube 120 so that the pins 130 press the blood vessel 20. In this method, preferably, the number of the pins 130 is one, or in the case that the number of the pins 130 is several, the pins 130 turn in the same direction. In the case that the pins 130 are radially spaced from one another by the same interval, when the hand lever 110 is pulled in the direction opposite to the inserted direction of the penetration tube 120, the arc-shaped pins 130 damage tissues distant from the blood vessel 20 as well as tissues around the blood vessel 20. Accordingly, one pin 130 may be provided or plural pins turning in the same direction may be provided, thereby minimizing damage to healthy tissues distant from the blood vessel 20. Preferably, the above two methods are selectively used in consideration of positions of the tissue 10 and the blood vessel 20 of the human body. The actuator 150 is inserted into the hand lever 110 through the opened end of the hand laver 110 having a hollowed cylindrical structure, and rectilinearly reciprocates along the inserted direction of the penefration tube 120. That is, the actuator 150 performs piston movement inside the hand lever 110. The actuator 150 is divided into one portion, which is inserted into the hand lever 110, and the other portion, which is protruded from the hand lever 110. The moving distance of the actuator 150 is limited by an inner space of the hand lever 110. The portion of the actuator 150, which is protruded from the hand lever 110, has a structure having an oval-shaped section, the long radius of which is larger than the radius of the hand lever 110 so that the protruded portion of the actuator 150 is easily gripped by a surgeon's hand. Accordingly, the actuator 150 easily performs the piston movement. Since the actuator 150 is connected to the pins 130, the actuator 150 is inserted into or protruded from the penetration tube 120 according to the rectilinear reciprocation. Accordingly, the size of the inner space of the hand lever 110 is adjusted, thereby controlling the protruded length of the pins 130. The holder 160 is installed on the outer surface of the penefration tube 120 such that the holder 160 slides along the outer surface of the penefration tube 120. In the case that the pins 130 pull the blood vessel 20 to press the blood vessel 20, the holder 160 contacts the skin of the tissue 10 of the human body and is fixed to the outer surface of the penetration tube 120, thus allowing the blood vessel 20 to maintain the pressed state. Since the holder 160 fixes the apparatus 100 as well as maintains the pressed state of the blood vessel 20, a surgeon's hand, which has fixed the apparatus 100, becomes free. Accordingly, the surgeon can perform an operation using both hands. Thereby, the surgeon can perform the operation using both hands, thus being capable of more precisely perforating the operation and perforating another operation. With the apparatus 100 of the present invention, the surgeon presses the blood vessel 20 to block the blood flow without incising the tissue 10 of a patient. FIG. 6 is a schematic side view of an apparatus for pressing a blood vessel in accordance with a second preferred embodiment of the present invention, FIG. 7 is a schematic front view ofthe apparatus shown in FIG. 6, and FIG. 8 is a schematic rear view ofthe apparatus shown in FIG.6. FIG. 9 is a schematic side view ofthe apparatus shown in FIG. 6 in a state in which pins and electrodes are protruded, and FIG. 10 is a schematic front view of the apparatus shown in FIG.6. With reference to FIGS. 6 to 10, the apparatus 200 for pressing a blood vessel in accordance with the second preferred embodiment ofthe present invention comprises a hand lever 210, a penefration tube 220, one end of which is connected to the hand lever 210 and the other end of which is shaφened so as to be inserted into a tissue 10 of the human body, pins 230 made of an elastic material, movably installed in the penefration tube 220, having arc shapes protruded from the other end of the penetration tube 220 in the direction peφendicular to an inserted direction ofthe penefration tube 220 under the condition that the penefration tube 220 is inserted into the tissue 10 ofthe human body, and serving to press a blood vessel 20 ofthe tissue 10 by pulling or pushing the blood vessel 20 for blocking blood flow, elecfrodes 240 installed in the penefration tube 220 movably together with the pins 230, having arc shapes protruded from the other end of the penetration tube 220 in the direction peφendicular to the inserted direction of the penefration tube 220, and serving to heat a lesion portion ofthe tissue 10 when the pins 230 press the blood vessel 20, an actuator 250 moved in the same direction ofthe longitudinal direction ofthe penetration tube 220 for inserting the pins 230 and the electrodes 240 into the penefration tube 220 or protruding the pins 230 and the elecfrodes 240 from the penetration tube 220, a holder 260 installed such that the holder 260 is movable along the outer surface of the penefration tube 220, and contacting a skin ofthe tissue 10 of the human body and fixed to the outer surface ofthe penefration tube 220 for maintaining the pressed state ofthe blood vessel 20 in the case that the pins 230 pull the blood vessel 20 to press the blood vessel 20, and a power unit 270 for supplying high-frequency power to the elecfrodes 240. With reference to FIGS. 6 to 10, parts ofthe apparatus 200 in accordance with the second embodiment are substantially the same as those of he apparatus 100 in accordance with the first embodiment except for the elecfrodes 240, the actuator 250, and the power unit 270. Thus, a detailed description of the parts of the apparatus 200 other than the elecfrodes 240, the actuator 250, and the power unit 270 will be omitted because it is considered to be unnecessary. In the same manner as the pins 130 ofthe apparatus 100 ofthe first embodiment, the pins 230 ofthe apparatus 200 ofthe second embodiment are coated with an insulating material. Since the pins 230 are coated with the insulating material, the pins 230 and the elecfrodes 240 are prevented from being electrically connected. Further, in the same manner as the pins 130 ofthe apparatus 100 ofthe first embodiment, preferably, Teflon is used as the insulating material. The elecfrodes 240 serve to heat the lesion portion of the tissue 10 of the human body, are movably installed in the penefration tube 220 simultaneously with or independently from the pins 230, and are protruded from the other end of the penetration tube 220 under the condition that the penetration tube 220 is inserted into the tissue of the human body. In the same manner as the pins 230, in the case that the electrodes 240 are located in the penefration tube 220, the electrodes 240 have rectilinear shapes, and in the case that the elecfrodes 240 are protruded from the other end of the penefration tube 220, the electrodes 240 have arc shapes to the direction peφendicular to the inserted direction ofthe penefration tube 220. In order to form the above-varied shapes, in the same manner as the pins 230, the elecfrodes 240 are made of a shape memory alloy having an arc shape. In the case that the elecfrodes 240 are located in the penefration tube 220, the inner surface of the penetration tube 220 serves as a guide, thereby maintaining the rectilinear shapes ofthe electrodes 240. However, in the case that the electrodes 240 are protruded from the other end of the penefration tube 220, the electrodes 240 are returned to their original shapes, i.e., the arc shapes, in the direction peφendicular to the inserted direction of the penetration tube 220. The elecfrodes 240 are made ofthe shape memory alloy containing one selected from the group consisting of a nickel-titanium (Ni-Ti) alloy, a nickel-titanium-copper (Ni-Ti-Cu) alloy, a nickel-titanium-cobalt (Ni-Ti-Co) alloy, and a copper-zinc-aluminum (Cu-Zn-Al) alloy. The material or property ofthe elecfrodes 240 are the same as those ofthe pins 130 ofthe apparatus 100 ofthe first embodiment, and a detailed description thereof will thus be omitted. The protruded length ofthe electrodes 240 may be various according to the position or size ofthe lesion portion, and, preferably, is longer than the protruded length ofthe pins 230. The number ofthe elecfrodes 240 may be various, and, preferably, is two. Although the electrodes 240 in the drawings are made of a shape memory alloy having an arc shape, the elecfrodes 240 may be made of metal having a rectilinear shape. Although not shown in the drawings, a sensor for measuring temperature may be provided on one end ofthe elecfrodes 240. The sensor detects the temperature ofthe lesion portion ofthe tissue 10 heated by the electrodes 240. The power unit 270 supplies power to the elecfrodes 240 for heating the lesion portion ofthe tissue 10. A high-frequency wave is mainly used as the power ofthe power unit 270. Alternately, a microwave or a laser may be used as the power ofthe power unit 270. The actuator 250 ofthe apparatus 200 ofthe second embodiment is similar to the actuator 150 ofthe apparatus 100 ofthe first embodiment, but differs from the actuator 150 ofthe apparatus 100 ofthe first embodiment in that a power connection unit 280 connected to the elecfrodes 240 and the power unit 270 is provided on the end of the actuator 250 protruded from the hand lever 210. The power connection unit 280 is connected to the power unit 270 through a cable extended from the power unit 270. hi the case that the pins 230 and the elecfrodes 240 are simultaneously protruded from the penefration tube 220, the actuator 250 has an integrated structure. In the case that the pins 230 and the electrodes 240 are independently protruded from the penefration tube 220, the actuator 250 includes one portion connected to the pins 230 for protruding the pins 230 from the penetration tube 220 or inserting the pins 230 into the penetration tube 220, and the other portion connected to the elecfrodes 240 for protruding the elecfrodes 240 from the penetration tube 220 or inserting the electrodes 240 into the penefration tube 220. hi this case, the power connection unit 280 is connected to the portion ofthe actuator 250 connected to the electrodes 240. The apparatus 200 of the second embodiment simultaneously comprises the pins 230 for pressing the blood vessel 20 to block the blood flow, and the electrodes 240 for heating the lesion portion ofthe tissue 10. Accordingly, the apparatus 200 can heat larger dimensions ofthe lesion portion ofthe tissue 10 at a higher temperature using the electrodes
240 under the condition that the blood flow ofthe blood vessel 20 is blocked by the pins 230. The increase of the temperature of the lesion portion of the tissue 10, such as a tumor, assists elimination of a cancer tissue. An exothermic therapy for cancer tissues has several effects. That is, the exothennic therapy varies permeability or fluidity of a cellular membrane (or a nuclear membrane), divides lysosome of cytoplasm for causing discharge of digestive enzyme, thermally damages protein influencing cellular respiration and synthesis of DNA or RNA, and stimulates the immune system. Now, a heat-emitting process ofthe elecfrodes 240 will be described, as follows.
High-frequency alternating current, generated due to hindrance of a high-frequency wave, flows from the elecfrodes 240 to a target tissue of a cell. Since ions are apt to comply with the change ofthe direction ofthe alternating current, agitation of ions occurs in an end cell tissue region close to the elecfrodes 240. Since the agitation ofthe ions generates heat due to friction, the tissue 10 around the elecfrodes 240 rather than the electrodes 240 is a main factor for generating heat. The generation of heat by the tissue 10 occurs when the current passes through electrical resistance supplied from the tissue 10. Here, the higher the resistance is, the higher the heat is. Since the current is spread radially from the ends of the elecfrodes 240, current density is highest at the ends of the elecfrodes 240, and is then gradually decreased away from the ends of the elecfrodes 240. Accordingly, the heating effect is highest at the elecfrodes 240, and is then gradually decreased away from the elecfrodes 240. As apparent from the above description, the present invention provides an apparatus, which presses a blood vessel to block blood flow using a penefration tube and pins without incising a tissue of a patient. Further, the apparatus of the present invention heats a lesion portion of the tissue using elecfrodes, thereby treating the lesion portion. Since the blood flow ofthe blood vessel is blocked, the apparatus ofthe present invention increases heating effects when the lesion portion ofthe tissue is heated, and needs not incise the tissue, thereby assisting recovery of patient' s health after operation.
Although the preferred embodiments of the present invention have been disclosed for illustrative puφoses, those skilled in the art will appreciate that various modifications, additions and substitutions are possible, without departing from the scope and spirit of the invention as disclosed in the accompanying claims.

Claims

WHAT IS CLAIMED IS:
1. An apparatus for pressing a blood vessel comprising: a hand lever; a penefration tube, one end of which is connected to the hand lever and the other end of which is shaφened so as to be inserted into a tissue ofthe human body; pins made of an elastic material, movably installed in the penefration tube, having arc shapes protruded from the other end ofthe penefration tube in the direction peφendicular to an inserted direction ofthe penefration tube under the condition that the penetration tube is inserted into the tissue, and serving to press the blood vessel by pulling or pushing the blood vessel for blocking blood flow; and an actuator moved in the same direction of the longitudinal direction of the penetration tube for inserting the pins into the penefration tube or protruding the pins from the penetration tube.
2. The apparatus as set forth in claim 1, further comprising a holder installed such that the holder is movable along the outer surface of the penefration tube, and contacting a skin of the tissue and fixed to the outer surface of the penefration tube for maintaining the pressed state ofthe blood vessel in the case that the pins pull the blood vessel to press the blood vessel.
3. The apparatus as set forth in claim 1 , wherein the pins are made of a shape memory alloy.
4. The apparatus as set forth in claim 3, wherein the shape memory alloy is one selected from the group consisting of a nickel-titanium (Ni-Ti) alloy, a nickel-titanium- copper (Ni-Ti-Cu) alloy, a nickel-titanium-cobalt (Ni-Ti-Co) alloy, and a copper-zinc- aluminum (Cu-Zn-Al) alloy.
5. The apparatus as set forth in claim 1, further comprising: electrodes installed in the penefration tube such that the elecfrodes are moved by the actuator, having arc shapes protruded from the other end of the penefration tube in the direction peφendicular to the inserted direction ofthe penefration tube when the penetration tube presses the blood vessel, and serving to heat a lesion portion of the tissue; and a power unit for supplying high-frequency power to the elecfrodes.
6. The apparatus as set forth in claim 5, wherein the pins are coated with an insulating material.
7. The apparatus as set forth in claim 6, wherein the insulating material is
Teflon.
PCT/KR2004/003275 2003-12-15 2004-12-14 Apparatus for pressing a blood vessel WO2005055837A1 (en)

Applications Claiming Priority (2)

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KR1020030091129A KR100624161B1 (en) 2003-12-15 2003-12-15 Apparatus for pressing a blood vessel

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
WO2022175946A1 (en) * 2021-02-17 2022-08-25 Dreamedic Ltd. Blood vessel compression systems

Citations (2)

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WO1995019148A1 (en) * 1994-01-18 1995-07-20 Endovascular, Inc. Apparatus and method for venous ligation
WO2003053259A2 (en) * 2000-12-29 2003-07-03 Afx, Inc. A tissue ablation apparatus with a sliding ablation instrument and method

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO1995019148A1 (en) * 1994-01-18 1995-07-20 Endovascular, Inc. Apparatus and method for venous ligation
WO2003053259A2 (en) * 2000-12-29 2003-07-03 Afx, Inc. A tissue ablation apparatus with a sliding ablation instrument and method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022175946A1 (en) * 2021-02-17 2022-08-25 Dreamedic Ltd. Blood vessel compression systems

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