WO2004082570A3 - Diagnostics and therapeutics for diseases associated with dopamine receptor d2 (drd2) - Google Patents

Diagnostics and therapeutics for diseases associated with dopamine receptor d2 (drd2) Download PDF

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Publication number
WO2004082570A3
WO2004082570A3 PCT/EP2004/002184 EP2004002184W WO2004082570A3 WO 2004082570 A3 WO2004082570 A3 WO 2004082570A3 EP 2004002184 W EP2004002184 W EP 2004002184W WO 2004082570 A3 WO2004082570 A3 WO 2004082570A3
Authority
WO
WIPO (PCT)
Prior art keywords
disorders
drd2
therapeutics
diagnostics
diseases associated
Prior art date
Application number
PCT/EP2004/002184
Other languages
French (fr)
Other versions
WO2004082570A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Holger Summer
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Holger Summer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Holger Summer filed Critical Bayer Healthcare Ag
Publication of WO2004082570A2 publication Critical patent/WO2004082570A2/en
Publication of WO2004082570A3 publication Critical patent/WO2004082570A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/9413—Dopamine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a human DRD2 which is associated with the endocrine system and hormone disorders, neurological disorders, respiratory diseases, cancer disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of endocrine system and hormone disorders, neurological disorders, respiratory diseases, cancer disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of DRD2 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2004/002184 2003-03-17 2004-03-04 Diagnostics and therapeutics for diseases associated with dopamine receptor d2 (drd2) WO2004082570A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03005469 2003-03-17
EP03005469.6 2003-03-17

Publications (2)

Publication Number Publication Date
WO2004082570A2 WO2004082570A2 (en) 2004-09-30
WO2004082570A3 true WO2004082570A3 (en) 2005-01-27

Family

ID=33016823

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/002184 WO2004082570A2 (en) 2003-03-17 2004-03-04 Diagnostics and therapeutics for diseases associated with dopamine receptor d2 (drd2)

Country Status (1)

Country Link
WO (1) WO2004082570A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017009841A (en) 2015-01-30 2018-02-09 Oncoceutics Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy.
NZ745425A (en) 2016-01-29 2023-03-31 Oncoceutics Inc G protein-coupled receptor (gpcr) modulation by imipridones
US10172862B2 (en) 2017-01-30 2019-01-08 Oncoceutics, Inc. Imipridones for gliomas
KR102128251B1 (en) * 2019-05-27 2020-06-30 사회복지법인 삼성생명공익재단 Biomarker Composition for Diagnosing Colorectal Cancer Specifically Binding to Arginine-methylated Dopamine Receptor D2
CN115068612B (en) * 2021-08-18 2023-05-23 四川大学华西第二医院 Application of DRD2 inhibitor in preparation of medicines for treating liver fibrosis-related diseases

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991005040A1 (en) * 1989-09-27 1991-04-18 The United States Of America, Represented By The Secretary, United States Department Of Commerce Cloned genes for human dopamine d2 receptors and cell lines expressing same
WO1996034094A1 (en) * 1995-04-26 1996-10-31 Inserm (Institut National De La Sante Et De La Recherche Medicale) Non-human transgenic animal with modified d2 receptor expression
WO1999066935A1 (en) * 1998-06-20 1999-12-29 Medical Research Council Male contraceptive comprising a prolactin inhibitor and a sex steroid
US20010005724A1 (en) * 1996-12-18 2001-06-28 Cross Dee L. Method for promoting ovulation, parturition, and lactation in mammals
WO2001072741A2 (en) * 2000-03-28 2001-10-04 Knoll Gmbh N-benzodioxanylmethyl-1-piperidyl-methylamine compounds for the treatment of central nervous system disorders
WO2002020491A1 (en) * 2000-09-05 2002-03-14 Merck Patent Gmbh Arylpiperazine derivatives and their use as psychotropic agents
US20020123096A1 (en) * 1988-11-18 2002-09-05 Oregon Health Sciences University. Dopamine receptors and genes
WO2003012143A1 (en) * 2001-07-16 2003-02-13 Price Foundation Limited Genes and snps associated with eating disorders

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020123096A1 (en) * 1988-11-18 2002-09-05 Oregon Health Sciences University. Dopamine receptors and genes
WO1991005040A1 (en) * 1989-09-27 1991-04-18 The United States Of America, Represented By The Secretary, United States Department Of Commerce Cloned genes for human dopamine d2 receptors and cell lines expressing same
WO1996034094A1 (en) * 1995-04-26 1996-10-31 Inserm (Institut National De La Sante Et De La Recherche Medicale) Non-human transgenic animal with modified d2 receptor expression
US20010005724A1 (en) * 1996-12-18 2001-06-28 Cross Dee L. Method for promoting ovulation, parturition, and lactation in mammals
WO1999066935A1 (en) * 1998-06-20 1999-12-29 Medical Research Council Male contraceptive comprising a prolactin inhibitor and a sex steroid
WO2001072741A2 (en) * 2000-03-28 2001-10-04 Knoll Gmbh N-benzodioxanylmethyl-1-piperidyl-methylamine compounds for the treatment of central nervous system disorders
WO2002020491A1 (en) * 2000-09-05 2002-03-14 Merck Patent Gmbh Arylpiperazine derivatives and their use as psychotropic agents
WO2003012143A1 (en) * 2001-07-16 2003-02-13 Price Foundation Limited Genes and snps associated with eating disorders

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1998, BROWNELL J: "Quinagolide in hyperprolactinaemia", XP002289640, Database accession no. EMB-1998093760 *
LAHTI R A ET AL: "DOPAMINE D-2 RECEPTOR BINDING PROPERTIES OF TRITIATED U-86170 A DOPAMINE RECEPTOR AGONIST", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 202, no. 2, 1991, pages 289 - 291, XP002289638, ISSN: 0014-2999 *
MORO MAKOTO ET AL: "Effects of dopamine D2 receptor agonists in a pituitary transplantation-induced hyperprolactinaemima/anovulation model in rats", CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol. 28, no. 8, August 2001 (2001-08-01), pages 651 - 658, XP002289639, ISSN: 0305-1870 *
REVIEWS IN CONTEMPORARY PHARMACOTHERAPY 1998 UNITED KINGDOM, vol. 9, no. 1, 1998, pages 1 - 75, ISSN: 0954-8602 *

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Publication number Publication date
WO2004082570A2 (en) 2004-09-30

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