WO2004046118A3 - 2-4-(di-phenyl-amino)-pyrimidine derivatives useful for treating hyper-proliferative disorders - Google Patents

2-4-(di-phenyl-amino)-pyrimidine derivatives useful for treating hyper-proliferative disorders Download PDF

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Publication number
WO2004046118A3
WO2004046118A3 PCT/US2003/014294 US0314294W WO2004046118A3 WO 2004046118 A3 WO2004046118 A3 WO 2004046118A3 US 0314294 W US0314294 W US 0314294W WO 2004046118 A3 WO2004046118 A3 WO 2004046118A3
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WO
WIPO (PCT)
Prior art keywords
amino
phenyl
proliferative disorders
pyrimidine derivatives
derivatives useful
Prior art date
Application number
PCT/US2003/014294
Other languages
French (fr)
Other versions
WO2004046118A2 (en
Inventor
Jill E Wood
Donald Bierer
Brian Bear
Catherine Brennan
Brent Chandler
Gang Chen
Yuanwei Chen
Julie Dixon
Wenlang Fu
Leatte Guernon
Donglei Liu
Andrea Mcclure
Karl Miranda
Dhanapalan Nagarathnam
Robert Sibley
Michael Turner
Sharad Verma
Chunguang Wang
Lin Yi
Jin Zhao
Qingming Zhu
Original Assignee
Bayer Pharmaceuticals Corp
Jill E Wood
Donald Bierer
Brian Bear
Catherine Brennan
Brent Chandler
Gang Chen
Yuanwei Chen
Julie Dixon
Wenlang Fu
Leatte Guernon
Donglei Liu
Andrea Mcclure
Karl Miranda
Dhanapalan Nagarathnam
Robert Sibley
Michael Turner
Sharad Verma
Chunguang Wang
Lin Yi
Jin Zhao
Qingming Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bayer Pharmaceuticals Corp, Jill E Wood, Donald Bierer, Brian Bear, Catherine Brennan, Brent Chandler, Gang Chen, Yuanwei Chen, Julie Dixon, Wenlang Fu, Leatte Guernon, Donglei Liu, Andrea Mcclure, Karl Miranda, Dhanapalan Nagarathnam, Robert Sibley, Michael Turner, Sharad Verma, Chunguang Wang, Lin Yi, Jin Zhao, Qingming Zhu filed Critical Bayer Pharmaceuticals Corp
Priority to AU2003299474A priority Critical patent/AU2003299474A1/en
Publication of WO2004046118A2 publication Critical patent/WO2004046118A2/en
Publication of WO2004046118A3 publication Critical patent/WO2004046118A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a 2-4-(diphenyl-amino)-pyrimidinyl compound of Formula I useful for treating hyper-proliferative disorders.
PCT/US2003/014294 2002-05-06 2003-05-06 2-4-(di-phenyl-amino)-pyrimidine derivatives useful for treating hyper-proliferative disorders WO2004046118A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003299474A AU2003299474A1 (en) 2002-05-06 2003-05-06 2-4-(di-phenyl-amino)-pyrimidine derivatives useful for treating hyper-proliferative disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37832902P 2002-05-06 2002-05-06
US60/378,329 2002-05-06

Publications (2)

Publication Number Publication Date
WO2004046118A2 WO2004046118A2 (en) 2004-06-03
WO2004046118A3 true WO2004046118A3 (en) 2004-08-12

Family

ID=29420382

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2003/013604 WO2003095448A1 (en) 2002-05-06 2003-05-02 Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders
PCT/US2003/014294 WO2004046118A2 (en) 2002-05-06 2003-05-06 2-4-(di-phenyl-amino)-pyrimidine derivatives useful for treating hyper-proliferative disorders

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2003/013604 WO2003095448A1 (en) 2002-05-06 2003-05-02 Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders

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AU (2) AU2003231231A1 (en)
WO (2) WO2003095448A1 (en)

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US8604042B2 (en) 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
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US9012462B2 (en) 2008-05-21 2015-04-21 Ariad Pharmaceuticals, Inc. Phosphorous derivatives as kinase inhibitors
US9248190B2 (en) 2005-06-08 2016-02-02 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
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US9346765B2 (en) 2002-02-01 2016-05-24 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds and their uses
US8835430B2 (en) 2002-02-01 2014-09-16 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds and their uses
US8557806B2 (en) 2002-07-29 2013-10-15 Rigel Pharmaceuticals, Inc. Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
US8476263B2 (en) 2005-01-19 2013-07-02 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
US8785437B2 (en) 2005-01-19 2014-07-22 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
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