WO2004035534A3 - Novel compounds having a dopaminergic and/or serotoninergic activity - Google Patents

Novel compounds having a dopaminergic and/or serotoninergic activity Download PDF

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Publication number
WO2004035534A3
WO2004035534A3 PCT/EP2003/011348 EP0311348W WO2004035534A3 WO 2004035534 A3 WO2004035534 A3 WO 2004035534A3 EP 0311348 W EP0311348 W EP 0311348W WO 2004035534 A3 WO2004035534 A3 WO 2004035534A3
Authority
WO
WIPO (PCT)
Prior art keywords
dopaminergic
novel compounds
serotoninergic activity
serotoninergic
activity
Prior art date
Application number
PCT/EP2003/011348
Other languages
German (de)
French (fr)
Other versions
WO2004035534A2 (en
Inventor
Vukic Soskic
Original Assignee
Proteosys Ag
Vukic Soskic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteosys Ag, Vukic Soskic filed Critical Proteosys Ag
Priority to AU2003293616A priority Critical patent/AU2003293616A1/en
Publication of WO2004035534A2 publication Critical patent/WO2004035534A2/en
Publication of WO2004035534A3 publication Critical patent/WO2004035534A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to novel compounds of 4-[2-(4-arylpiperazin-1-yl)-ethoxy]benzo-1,2-diamine I, to the derivatives thereof in the form of benzoimidazole-2-thiones, benzoimidazoles and benzotriazoles, to the use of the pharmacologically acceptable salts thereof as dopaminergic and serotoninergic agents, and to a method for producing said compounds.
PCT/EP2003/011348 2002-10-15 2003-10-14 Novel compounds having a dopaminergic and/or serotoninergic activity WO2004035534A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003293616A AU2003293616A1 (en) 2002-10-15 2003-10-14 Novel compounds having a dopaminergic and/or serotoninergic activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10248925A DE10248925A1 (en) 2002-10-15 2002-10-15 New compounds with dopaminergic and / or serotonergic activity
DE10248925.4 2002-10-15

Publications (2)

Publication Number Publication Date
WO2004035534A2 WO2004035534A2 (en) 2004-04-29
WO2004035534A3 true WO2004035534A3 (en) 2004-06-17

Family

ID=32049491

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/011348 WO2004035534A2 (en) 2002-10-15 2003-10-14 Novel compounds having a dopaminergic and/or serotoninergic activity

Country Status (3)

Country Link
AU (1) AU2003293616A1 (en)
DE (1) DE10248925A1 (en)
WO (1) WO2004035534A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1988077A4 (en) * 2006-02-23 2009-09-02 Shionogi & Co Nirogenous heterocyclic derivatives substituted with cyclic groups
US8420680B2 (en) * 2007-06-29 2013-04-16 Emory University NMDA receptor antagonists for neuroprotection
JPWO2009025265A1 (en) * 2007-08-21 2010-11-25 塩野義製薬株式会社 Piperazine derivatives
EP2296658A4 (en) * 2008-05-09 2014-01-15 Univ Emory Nmda receptor antagonists for the treatment of neuropsychiatric disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS579769A (en) * 1980-06-23 1982-01-19 Otsuka Pharmaceut Co Ltd 2-benzimidazolinone derivative
US5948775A (en) * 1997-03-19 1999-09-07 American Home Products Corporation 2- or 3-(substitutedaminoalkoxyphenyl)quinazolin-4-ones
WO2004022534A1 (en) * 2002-09-09 2004-03-18 Nps Allelix Corp. Arylglycine derivatives for use as glycine transport inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0694535A1 (en) * 1994-04-29 1996-01-31 Eli Lilly And Company Non-peptidyl tachykinin receptor antagonists
JP4745547B2 (en) * 2000-07-14 2011-08-10 富山化学工業株式会社 Novel benzimidazole derivatives or salts thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS579769A (en) * 1980-06-23 1982-01-19 Otsuka Pharmaceut Co Ltd 2-benzimidazolinone derivative
US5948775A (en) * 1997-03-19 1999-09-07 American Home Products Corporation 2- or 3-(substitutedaminoalkoxyphenyl)quinazolin-4-ones
WO2004022534A1 (en) * 2002-09-09 2004-03-18 Nps Allelix Corp. Arylglycine derivatives for use as glycine transport inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DUKIC S ET AL: "SYNTHESIS OF SEVERAL SUBSITUTED PHENYLPIPERAZINES BEHAVING AS MIXED D2/5HT1A LIGANDS", JOURNAL OF PHARMACY AND PHARMACOLOGY, LONDON, GB, vol. 49, no. 10, 1997, pages 1036 - 1041, XP001095638, ISSN: 0022-3573 *
PATENT ABSTRACTS OF JAPAN *
ROGLIC G ET AL: "INVESTIGATION OF MIXED D2/5-HT1A ACTIVITY OF N-HETEROARYLMETHYL-N-PHENYL-PIPERAZINES, N-HETEROARYLETHYL-N-PHENYLPI PERAZINES AND N-HETEROARYLPROPYL-N-PHENYLPIPERAZINES", PHARMAZIE, VEB VERLAG VOLK UND GESUNDHEIT. BERLIN, DD, vol. 56, no. 10, October 2001 (2001-10-01), pages 803 - 807, XP001179245, ISSN: 0031-7144 *

Also Published As

Publication number Publication date
AU2003293616A1 (en) 2004-05-04
DE10248925A1 (en) 2004-04-29
AU2003293616A8 (en) 2004-05-04
WO2004035534A2 (en) 2004-04-29

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