WO2004016753A3 - Antibodies that immunospecifically bind to trail receptors - Google Patents

Antibodies that immunospecifically bind to trail receptors Download PDF

Info

Publication number
WO2004016753A3
WO2004016753A3 PCT/US2003/025457 US0325457W WO2004016753A3 WO 2004016753 A3 WO2004016753 A3 WO 2004016753A3 US 0325457 W US0325457 W US 0325457W WO 2004016753 A3 WO2004016753 A3 WO 2004016753A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
immunospecifically bind
relates
methods
trail receptors
Prior art date
Application number
PCT/US2003/025457
Other languages
French (fr)
Other versions
WO2004016753A2 (en
Inventor
Theodora Salcedo
Steven M Ruben
Craig A Rosen
Vivian A Albert
Original Assignee
Human Genome Sciences Inc
Theodora Salcedo
Steven M Ruben
Craig A Rosen
Vivian A Albert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc, Theodora Salcedo, Steven M Ruben, Craig A Rosen, Vivian A Albert filed Critical Human Genome Sciences Inc
Priority to EP03788476A priority Critical patent/EP1534336A4/en
Priority to AU2003259835A priority patent/AU2003259835A1/en
Priority to CA2494372A priority patent/CA2494372C/en
Publication of WO2004016753A2 publication Critical patent/WO2004016753A2/en
Publication of WO2004016753A3 publication Critical patent/WO2004016753A3/en
Priority to US10/986,047 priority patent/US7348003B2/en
Priority to US10/986,349 priority patent/US20050214209A1/en
Priority to US10/986,046 priority patent/US20050129616A1/en
Priority to US10/986,376 priority patent/US20050214210A1/en
Priority to US11/391,384 priority patent/US7361341B2/en
Priority to US12/016,372 priority patent/US20090226429A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
PCT/US2003/025457 2001-05-25 2003-08-15 Antibodies that immunospecifically bind to trail receptors WO2004016753A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP03788476A EP1534336A4 (en) 2002-08-15 2003-08-15 Antibodies that immunospecifically bind to trail receptors
AU2003259835A AU2003259835A1 (en) 2002-08-15 2003-08-15 Antibodies that immunospecifically bind to trail receptors
CA2494372A CA2494372C (en) 2002-08-15 2003-08-15 Antibodies that immunospecifically bind to trail receptors
US10/986,047 US7348003B2 (en) 2001-05-25 2004-11-12 Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US10/986,349 US20050214209A1 (en) 2001-05-25 2004-11-12 Antibodies that immunospecifically bind to TRAIL receptors
US10/986,046 US20050129616A1 (en) 2001-05-25 2004-11-12 Antibodies that immunospecifically bind to TRAIL receptors
US10/986,376 US20050214210A1 (en) 2001-05-25 2004-11-12 Antibodies that immunospecifically bind to TRAIL receptors
US11/391,384 US7361341B2 (en) 2001-05-25 2006-03-29 Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
US12/016,372 US20090226429A1 (en) 2001-05-25 2008-01-18 Antibodies That Immunospecifically Bind to TRAIL Receptors

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US40338202P 2002-08-15 2002-08-15
US60/403,382 2002-08-15
US42573002P 2002-11-13 2002-11-13
US60/425,730 2002-11-13
US46805003P 2003-05-06 2003-05-06
US60/468,050 2003-05-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/139,785 Continuation-In-Part US7064189B2 (en) 2001-05-25 2002-05-07 Antibodies that immunospecifically bind to trail receptors

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US10/986,376 Continuation-In-Part US20050214210A1 (en) 2001-05-25 2004-11-12 Antibodies that immunospecifically bind to TRAIL receptors
US10/986,349 Continuation-In-Part US20050214209A1 (en) 2001-05-25 2004-11-12 Antibodies that immunospecifically bind to TRAIL receptors
US10/986,047 Continuation-In-Part US7348003B2 (en) 2001-05-25 2004-11-12 Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US10/986,046 Continuation-In-Part US20050129616A1 (en) 2001-05-25 2004-11-12 Antibodies that immunospecifically bind to TRAIL receptors
US11/391,384 Continuation-In-Part US7361341B2 (en) 2001-05-25 2006-03-29 Methods of treating cancer using antibodies that immunospecifically bind to trail receptors

Publications (2)

Publication Number Publication Date
WO2004016753A2 WO2004016753A2 (en) 2004-02-26
WO2004016753A3 true WO2004016753A3 (en) 2004-06-17

Family

ID=31892094

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/025457 WO2004016753A2 (en) 2001-05-25 2003-08-15 Antibodies that immunospecifically bind to trail receptors

Country Status (4)

Country Link
EP (1) EP1534336A4 (en)
AU (1) AU2003259835A1 (en)
CA (1) CA2494372C (en)
WO (1) WO2004016753A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9238064B2 (en) 2008-03-03 2016-01-19 University Of Miami Allogeneic cancer cell-based immunotherapy

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005046732A2 (en) * 2003-11-04 2005-05-26 THE UNITED SATES OF AMERICA as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES, NIH Methods and compositions for the inhibition of hiv-1 replication
BRPI0417517A (en) * 2003-12-11 2007-03-06 Schering Ag method for improving efficacy of therapeutic radiolabelled drugs
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
PE20140196A1 (en) 2007-08-09 2014-03-19 Boehringer Ingelheim Int ANTI-CD37 ANTIBODIES
JP2015517511A (en) * 2012-05-16 2015-06-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Combined use of CD37 antibody and ICE (ifosfamide, carboplatin, etoposide)
SI2970473T1 (en) 2013-03-14 2017-10-30 Bristol-Myers Squibb Company Combination of dr5 agonist and anti-pd-1 antagonist and methods of use
UA124972C2 (en) 2016-07-29 2021-12-22 Янссен Фармацевтика Нв Methods of treating prostate cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030190685A1 (en) * 2001-05-25 2003-10-09 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1053256T3 (en) * 1998-01-26 2011-10-03 Genentech Inc Antibodies to Death Receptor 4 (DR4) and Applications thereof
DK1303293T3 (en) * 2000-07-27 2009-03-30 Genentech Inc Sequential administration of CPT-11 and APO-2L polypeptide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030190685A1 (en) * 2001-05-25 2003-10-09 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1534336A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9238064B2 (en) 2008-03-03 2016-01-19 University Of Miami Allogeneic cancer cell-based immunotherapy

Also Published As

Publication number Publication date
AU2003259835A1 (en) 2004-03-03
EP1534336A4 (en) 2005-12-14
EP1534336A2 (en) 2005-06-01
CA2494372C (en) 2013-05-28
WO2004016753A2 (en) 2004-02-26
CA2494372A1 (en) 2004-02-26
AU2003259835A8 (en) 2004-03-03

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