WO2004002999A2 - Modified 2' and 3' -nucleoside produgs for treating flaviridae infections - Google Patents
Modified 2' and 3' -nucleoside produgs for treating flaviridae infections Download PDFInfo
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- WO2004002999A2 WO2004002999A2 PCT/IB2003/003246 IB0303246W WO2004002999A2 WO 2004002999 A2 WO2004002999 A2 WO 2004002999A2 IB 0303246 W IB0303246 W IB 0303246W WO 2004002999 A2 WO2004002999 A2 WO 2004002999A2
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- 0 C*(C(*=C)=SC(C)=*1)C1=O Chemical compound C*(C(*=C)=SC(C)=*1)C1=O 0.000 description 15
- UZHKJZZQGXMAKP-UHFFFAOYSA-N C[n]1c(N)c(C(N)=O)nc1 Chemical compound C[n]1c(N)c(C(N)=O)nc1 UZHKJZZQGXMAKP-UHFFFAOYSA-N 0.000 description 1
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Definitions
- This invention is in the area of pharmaceutical chemistry, and is in particular, a 2' and/or 3' prodrug of 6-modified, V, 2', 3' or 4'-branched pyrimidine nucleoside or 8- modif ⁇ ed, 1', 2', 3' or 4 '-branched purine nucleoside for the treatment of a Flaviviridae infection, such as a hepatitis C virus infection.
- a Flaviviridae infection such as a hepatitis C virus infection.
- the Flaviviridae family of viruses comprises at least three distinct genera: pestiviruses, which cause disease in cattle and pigs; flaviviruses, which are the primary cause of diseases such as dengue fever and yellow fever; and hepaciviruses, whose sole member is HCV.
- the flavivirus genus includes more than 68 members separated into groups on the basis of serological relatedness (Calisher et al., J. Gen. Virol, 1993, 70, 37-
- Flaviviruses of global concern that are associated with human disease include the dengue hemorrhagic fever viruses (DHF), yellow fever virus, shock syndrome and Japanese encephalitis virus (Halstead, S.
- the pestivirus genus includes bovine viral diarrhea virus (BVDV), classical swine fever virus (CSFV, also called hog cholera virus) and border disease virus (BDV) of sheep (Moennig, V. et al. Adv. Vir. Res. 1992, 41, 53-98). Pestivirus infections of domesticated livestock (cattle, pigs and sheep) cause significant economic losses worldwide. BVDV causes mucosal disease in cattle and is of significant economic importance to the livestock industry (Meyers, G. and Thiel, H.-J., Advances in Virus Research, 1996, 47, 53-118; Moennig V., et al, Adv. Vir. Res. 1992, 41, 53-98). Human pestiviruses have not been as extensively characterized as the animal pestiviruses. However, serological surveys indicate considerable pestivirus exposure in humans.
- BVDV bovine viral diarrhea virus
- CSFV classical swine fever virus
- BDV border disease virus
- Pestiviruses and hepaciviruses are closely related virus groups within the Flaviviridae family.
- Other closely related viruses in this family include the GB virus A, GB virus A-like agents, GB virus-B and GB virus-C (also called hepatitis G virus, HGV).
- the hepacivirus group (hepatitis C virus; HCV) consists of a number of closely related but genotypically distinguishable viruses that infect humans. There are approximately 6 HCV genotypes and more than 50 subtypes.
- bovine viral diarrhea virus Due to the similarities between pestiviruses and hepaciviruses, combined with the poor ability of hepaciviruses to grow efficiently in cell culture, bovine viral diarrhea virus (BVDV) is often used as a sunogate to study the HCV virus.
- BVDV bovine viral diarrhea virus
- RNA viruses possess a single large open reading frame (ORF) encoding all the viral proteins necessary for virus replication. These proteins are expressed as a polyprotein that is co- and post-translationally processed by both cellular and virus-encoded proteinases to yield the mature viral proteins.
- the viral proteins responsible for the replication of the viral genome RNA are located within approximately the carboxy-terminal. Two-thirds of the ORF are termed nonstructural (NS) proteins.
- NS nonstructural
- the mature nonstructural (NS) proteins in sequential order from the amino-terminus of the nonstructural protein coding region to the carboxy-terminus of the ORF, consist of p7, NS2 5 NS3, NS4A, NS4B, NS5A, and NS5B.
- the NS proteins of pestiviruses and hepaciviruses share sequence domains that are characteristic of specific protein functions.
- the NS3 proteins of viruses in both groups possess amino acid sequence motifs characteristic of serine proteinases and of helicases (Gorbalenya et al. (1988) Nature 333:22; Bazan and Fletterick (1989) Virology 111 -.631-639; Gorbalenya et al. (1989) Nucleic Acid Res. 17.3889-3897).
- the NS5B proteins of pestiviruses and hepaciviruses have the motifs characteristic of RNA- directed RNA polymerases (Koonin, EN. and Dolja, VN. (1993) Crit. Rev. Biochem.
- RNA-directed RNA polymerases activity (Behrens et al.(1996) EMBO J. 15:12-22;
- HCV hepatitis C virus
- HCV Hepatitis B Virus
- HCV is an enveloped virus containing a positive-sense single-stranded RNA genome of approximately 9.4kb.
- the viral genome consists of a 5' untranslated region (UTR), a long open reading frame encoding a polyprotein precursor of approximately 3011 amino acids, and a short 3' UTR.
- the 5' UTR is the most highly conserved part of the HCV genome and is important for the initiation and control of polyprotein translation.
- Translation of the HCV genome is initiated by a cap-independent mechanism known as internal ribosome entry. This mechanism involves the binding of ribosomes to an RNA sequence known as the internal ribosome entry site (IRES).
- IRES internal ribosome entry site
- Viral structural proteins include a nucleocapsid core protein (C) and two envelope glycoproteins, El and E2.
- HCV also encodes two proteinases, a zinc-dependent metalloproteinase encoded by the NS2-NS3 region and a serine proteinase encoded in the NS3 region. These proteinases are required for cleavage of specific regions of the precursor polyprotein into mature peptides.
- the carboxyl half of nonstructural protein 5, NS5B contains the RNA- dependent RNA polymerase.
- the function of the remaining nonstructural proteins, NS4A and NS4B, and that of NS5A remain unknown.
- IFNs Interferons
- Flaviviridae including HCV, treatments, using interferon-based therapies.
- U.S. Patent No. 5,980,884 to Blatt et al. discloses methods for retreatment of patients afflicted with HCV using consensus interferon.
- U.S. Patent No. 5,980,884 to Blatt et al. discloses methods for retreatment of patients afflicted with HCV using consensus interferon.
- U.S. Patent No. 5,980,884 to Blatt et al. discloses methods for retreatment of patients afflicted with HCV using consensus interferon.
- Patent No. 5,942,223 to Bazer et al. discloses an anti-HCV therapy using ovine or bovine interferon-tau.
- U.S. Patent No. 5,928,636 to Alber et al. discloses the combination therapy of interleukin- 12 and interferon alpha for the treatment of infectious diseases including HCV.
- U.S. Patent No. 5,849,696 to Chretien et al. discloses the use of thymosins, alone or in combination with interferon, for treating HCV.
- U.S. Patent No. 5,830,455 to Valtuena et al. discloses a combination HCV therapy employing interferon and a free radical scavenger.
- 5,738,845 to Imakawa discloses the use of human interferon tau proteins for treating HCV.
- Other interferon-based treatments for HCV are disclosed in U.S. Patent No. 5,676,942 to Testa et al, U.S. Patent No. 5,372,808 to Blatt et al, and U.S. Patent No. 5,849,696.
- a number of patents also disclose pegylated forms of interferon, such as, U.S.
- Interferon alpha-2a and interferon alpha-2b are cunently approved as monotherapy for the treatment of HCV.
- ROFERON®-A (Roche) is the recombinant form of interferon alpha-2a.
- PEGASYS® (Roche) is the pegylated (i.e. polyethylene glycol modified) form of interferon alpha-2a.
- INTRON®A (Schering Corporation) is the recombinant form of Interferon alpha-2b
- PEG-INTRON® Schering Corporation
- Other forms of interferon alpha, as well as interferon beta, gamma, tau and omega are currently in clinical development for the treatment of HCV.
- INFERGEN interferon alphacon-1 by InterMune
- OMNIFERON natural interferon
- ALBUFERON Human Genome Sciences
- REBIF interferon beta- la
- Ares-Serono Omega Interferon by BioMedicine
- Oral Interferon Alpha by Amarillo Biosciences
- interferon gamma interferon tau
- interferon gamma- lb by InterMune
- Ribavirin (l- ⁇ -D-ribofuranosyl-l-l,2,4-triazole-3-carboxamide) is a synthetic, non- interferon-inducing, broad spectrum antiviral nucleoside analog sold under the trade name, Virazole (The Merck Index, 11th edition, Editor: Budavari, S., Merck & Co., Inc., Rahway, NJ, pl304, 1989). United States Patent No. 3,798,209 and RE29,835 disclose and claim ribavirin. Ribavirin is structurally similar to guanosine, and has in vitro activity against several DNA and RNA viruses including Flaviviridae (Gary L. Davis. Gastroenterology 118:S104-S114, 2000).
- Ribavirin reduces serum amino transferase levels to normal in 40% of patients, but it does not lower serum levels of HCV-RNA (Gary L. Davis. Gastroenterology 118:S104-
- ribavirin alone is not effective in reducing viral RNA levels. Additionally, ribavirin has significant toxicity and is known to induce anemia.
- Ribavirin is not approved fro monotherapy against HCV. It has been approved in combination with interferon alpha-2a or interferon alpha-2b for the treatment of HCV.
- the current standard of care for chronic hepatitis C is combination therapy with an alpha interferon and ribavirin.
- the combination of interferon and ribavirin for the treatment of HCV infection has been reported to be effective in the treatment of interferon naive patients (Battaglia, A.M. et al, Ann. Pharmacother. 34:487-494, 2000), as well as for treatment of patients when histological disease is present (Berenguer, M. et al. Antivir. Ther. 3(Suppl. 3): 125-136, 1998).
- PEGASYS® pegylated interferon alpha-2a
- COPEGUS® ribavirin
- PCT Publication Nos. WO 99/59621, WO 00/37110, WO 01/81359, WO 02/32414 and WO 03/024461 by Schering Corporation disclose the use of pegylated interferon alpha and ribavirin combination therapy for the treatment of HCV.
- PCT Publication Nos. WO 99/15194, WO 99/64016, and WO 00/24355 by Hoffmann-La Roche Inc also disclose the use of pegylated interferon alpha and ribavirin combination therapy for the treatment of HCV.
- HCV-derived enzymes such as protease, helicase, and polymerase inhibitors
- Drugs that inhibit other steps in HCV replication are also in development, for example, drugs that block production of HCV antigens from the RNA (IRES inhibitors), drugs that prevent the normal processing of HCV proteins (inhibitors of glycosylation), drugs that block entry of HCV into cells (by blocking its receptor) and nonspecific cytoprotective agents that block cell injury caused by the virus infection.
- ribozymes which are enzymes that break down specific viral RNA molecules
- antisense oligonucleotides which are small complementary segments of DNA that bind to viral RNA and inhibit viral replication
- Substrate-based NS3 protease inhibitors (Attwood et al, Antiviral peptide derivatives, PCT WO 98/22496, 1998; Attwood et al, Antiviral Chemistry and Chemotherapy 1999, 10, 259-273; Attwood et al, Preparation and use of amino acid derivatives as anti-viral agents, German Patent Pub. DE 19914474; Tung et al.
- Inhibitors of serine proteases particularly hepatitis C virus NS3 protease, PCT WO 98/17679), including alphaketoamides and hydrazinoureas, and inhibitors that terminate in an electrophile such as a boronic acid or phosphonate (Llinas-Brunet et al, Hepatitis C inhibitor peptide analogues, PCT WO 99/07734) are being investigated.
- Non-substrate-based NS3 protease inhibitors such as 2,4,6-trihydroxy-3-nitro- benzamide derivatives (Sudo K. et al, Biochemical and Biophysical Research Communications, 1997, 238, 643-647; Sudo K. et al. Antiviral Chemistry and Chemotherapy, 1998, 9, 186), including RD3-4082 and RD3-4078, the former substituted on the amide with a 14 carbon chain and the latter processing a /r ⁇ r ⁇ -phenoxyphenyl group are also being investigated.
- Sch 68631 a phenanthrenequinone
- HCV protease inhibitor Chom M. et al, Tetrahedron Letters 37:7229-7232, 1996.
- Sch 351633 isolated from the fungus Penicillium griseofulvum, was identified as a protease inhibitor (Chu M. et al, Bioorganic and Medicinal Chemistry Letters 9:1949-1952).
- Nanomolar potency against the HCV NS3 protease enzyme has been achieved by the design of selective inhibitors based on the macromolecule eglin c.
- Eglin c isolated from leech, is a potent inhibitor of several serine proteases such as S. griseus proteases A and B, ⁇ - chymotrypsin, chymase and subtilisin. Qasim M.A. et al, Biochemistry 36:1598-1607,
- U.S. patents disclose protease inhibitors for the treatment of HCV.
- U.S. Patent No. 6,004,933 to Spruce et al. discloses a class of cysteine protease inhibitors for inhibiting HCV endopeptidase 2.
- U.S. Patent No. 5,990,276 to Zhang et al. discloses synthetic inhibitors of hepatitis C virus NS3 protease. The inhibitor is a subsequence of a substrate of the NS3 protease or a substrate of the NS4A cofactor.
- restriction enzymes to treat HCV is disclosed in U.S. Patent No. 5,538,865 to Reyes et al.
- HCV inhibitor tripeptides are disclosed in US Patent Nos. 6,534,523, 6,410,531, and
- Diaryl peptides as NS3 serine protease inhibitors of HCV are disclosed in WO 02/48172 to Schering Corporation.
- Imidazoleidinones as NS3 serine protease inhibitors of HCV are disclosed in WO 02/08198 to Schering Corporation and WO 02/48157 to Bristol Myers Squibb.
- Squibb also disclose HCV protease inhibitors.
- Helicase inhibitors for example Diana G.D. et al, Compounds, compositions and methods for treatment of hepatitis C, U.S. Pat. No. 5,633,358; Diana G.D. et al, Piper idine derivatives, pharmaceutical compositions thereof and their use in the treatment of hepatitis C, PCT WO 97/36554;
- S-ODN Antisense phosphorothioate oligodeoxynucleotides (S-ODN) complementary to sequence stretches in the 5' non-coding region (NCR) of the virus (Alt M. et al,
- nucleotides 326-348 comprising the 3' end of the NCR and nucleotides 371-388 located in the core coding region of the HCV RNA
- Alt M. et al Archives of Virology, 1997, 142, 589-599; Galderisi U. et al, Journal of Cellular Physiology, 1999, 181, 251-257
- Inhibitors of IRES-dependent translation Ikeda N et al. , Agent for the prevention and treatment of hepatitis C, Japanese Patent Pub. JP-08268890; Kai Y. et al. Prevention and treatment of viral diseases, Japanese Patent Pub. JP-10101591);
- Ribozymes such as nuclease-resistant ribozymes (Maccjak, D. J. et al, Hepatology 1999, 30, abstract 995) and those disclosed in U.S. Patent No. 6,043,077 to Barber et al, and U.S. Patent Nos. 5,869,253 and 5,610,054 to
- Idenix Pharmaceuticals discloses the use of branched nucleosides in the treatment of flaviviruses (including HCV) and pestiviruses in International Publication Nos. WO
- hepatitis C infection and flaviviruses and pestiviruses
- a method for the treatment of hepatitis C infection (and flaviviruses and pestiviruses) in humans and other host animals is disclosed in the Idenix publications that includes administering an effective amount of a biologically active 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleosides or a pharmaceutically acceptable salt or derivative thereof, administered either alone or in combination with another antiviral agent, optionally in a pharmaceutically acceptable canier.
- Patent No. 6,034,134 to Gold et al alkyl lipids (U.S. Pat. No. 5,922,757 to Chojkier et al), vitamin E and other antioxidants (U.S. Pat. No. 5,922,757 to Chojkier et al), squalene, amantadine, bile acids (U.S. Pat. No. 5,846,964 to Ozeki et al), N-(phosphonoacetyl)-L- aspartic acid, (U.S. Pat. No. 5,830,905 to Diana et al), benzenedicarboxamides (U.S. Pat. No. 5,633,388 to Diana et al), polyadenylic acid derivatives (U.S. Pat. No. 5,496,546 to
- RNA replication inhibitors (VP50406) by ViroPharma/Wyeth, therapeutic vaccine by Intercell, therapeutic vaccine by Epimmune/Genencor, IRES inhibitor by Anadys, ANA 245 and ANA 246 by Anadys, immunotherapy (Therapore) by Avant, protease inhibitor by Corvas/SChering, helicase inhibitor by Vertex, fusion inhibitor by Trimeris, T cell therapy by CellExSys, polymerase inhibitor by Biocryst, targeted RNA chemistry by PTC Therapeutics, Dication by Immtech, Int., protease inhibitor by Agouron, protease inhibitor by Chiron/Medivir, anti
- Nucleoside prodrugs have been previously described for the treatment of other forms of hepatitis.
- WO 00/09531 (filed August 10, 1999) and WO 01/96353 (filed June 15, 2001) to Idenix Pharmaceuticals discloses 2'-deoxy- ⁇ -L-nucleosides and their 3 '-prodrugs for the treatment of HBV.
- U.S. Patent No. 4,957,924 to Beauchamp discloses various therapeutic esters of acyclovir. In light of the fact that HCV infection has reached epidemic levels worldwide, and has tragic effects on the infected patient, there remains a strong need to provide new effective pharmaceutical agents to treat hepatitis C that have low toxicity to the host.
- 2' and 3'-prodrugs of 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleosides, or their pharmaceutically acceptable salts or pharmaceutically acceptable formulations containing these compounds are useful in the prevention and treatment of Flaviviridae infections and other related conditions such as anti- Flaviviridae antibody positive and Flaviviridae - positive conditions, chronic liver inflammation caused by HCV, cinhosis, acute hepatitis, fulminant hepatitis, chronic persistent hepatitis, and fatigue.
- These compounds or formulations can also be used prophylactically to prevent or retard the progression of clinical illness in individuals who are anti-Flaviviridae antibody or Flaviviridae-antigen positive or who have been exposed to a Flaviviridae.
- a method for the treatment of a Flaviviridae viral infection in a host, including a human includes administering an effective amount of a 2' or 3'- prodrug of a biologically active 1', , 3' or 4 '-branched ⁇ -D or ⁇ -L nucleoside or a pharmaceutically acceptable salt thereof, administered either alone or in combination or alternation with another anti-Flaviviridae agent, optionally in a pharmaceutically acceptable canier.
- 2 '-prodrug refers to a 1', 2', 3' or 4 '-branched ⁇ -D or ⁇ -L nucleoside that has a biologically cleavable moiety at the 2 '-position, including, but not limited to acyl, and in one embodiment, a natural or synthetic D or L amino acid, preferably an L-amino acid.
- 3 '-prodrug refers to a 1', 2', 3' or 4 '-branched ⁇ -D or ⁇ -L nucleoside that has a biologically cleavable moiety at the 3 '-position, including, but not limited to acyl, and in one embodiment, a natural or synthetic D or L amino acid, preferably an L-amino acid.
- Pharmaceutically acceptable salts include tosylate, methanesulfonate, acetate, citrate, malonate, tartarate, succinate, benzoate, ascorbate, ⁇ -ketoglutarate, and ⁇ - glycerophosphate, formate, fumarate, propionate, glycolate, lactate, pyruvate, oxalate, maleate, salicyate, sulfate, sulfonate, nitrate, bicarbonate, hydrobromate, hydrobromide, hydroiodide, carbonate, and phosphoric acid salts.
- a particularly preferred embodiment is the mono or dihydrochloride salt.
- the 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside includes biologically cleavable moieties at the 2' and/or 5' positions.
- Prefened moieties are natural or synthetic D or L amino acid esters, including D or L-valyl, though preferably L-amino acid esters, such as L-valyl, and alkyl esters including acetyl.
- this invention specifically includes 2'-D or L-amino acid ester and 2',5'-D or L-diamino acid ester, preferably L-amino acid ester, of V, 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleosides with any desired purine or pyrimidine base, wherein the parent drug optionally has an EC 50 of less than 15 micromolar, and even more preferably less than 10 micromolar; 2 '-(alkyl or aryl) ester or 2',5'-di(alkyl or aryl) ester of 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleosides with any desired purine or pyrimidine base, wherein the parent drug optionally has an EC 50 of less than 10 or 15 micromolar; and prodrugs of 2',5'-diesters of 1', 2', 3' or 4'-branched ⁇ - D or ⁇
- prodrugs falling within the invention are 2',5'-L-divaline ester of ⁇ -D-2',6-dimethyl-cytidine (dival-2',6-diMe-L-dC); 2',5'-L-divaline ester of ⁇ -D- 2',6-dimethyl-thymidine; 2',5'-L-divaline ester of ⁇ -D-2',8-dirnethyl-adenosine; 2',5'-L- divaline ester of ⁇ -D-2',8-dimethyl-guanosine; 2',5'-L-divaline ester of ⁇ -D-2',6-dimethyl- 5-fluoro-cytidine; 2',5'-L-divaline ester of ⁇ -D-2',6-dimethyl-uridine; 2',5'-diacetyl ester of ⁇ -D-2',6-dimethyl
- the 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside 3'- prodrug includes biologically cleavable moieties at the 3' and/or 5' positions.
- Preferred moieties are natural or synthetic D or L amino acid esters, such as valyl, though preferably L-amino acids, such as L-valyl, and alkyl esters including acetyl.
- this invention specifically includes 3 '-L-amino acid ester and 3',5'-L-diamino acid ester of 1', 2', 3' or 4'- branched ⁇ -D or ⁇ -L nucleosides with any desired purine or pyrimidine base, wherein the parent drug optionally has an EC 50 of less than 15 micromolar, and even more preferably less than 10 micromolar; 3'-(alkyl or aryl) ester or 3',5'-L-di(alkyl or aryl) ester of 1', 2', 3' or 4 '-branched ⁇ -D or ⁇ -L nucleosides with any desired purine or pyrimidine base, wherein the parent drug optionally has an EC 5 o of less than 10 or 15 micromolar; and prodrugs of
- 3 ',5 '-diesters of V, 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleosides wherein (i) the 3' ester is a natural or synthetic D or L amino acid ester and the 5 '-ester is an alkyl or aryl ester; (ii) both esters are natural or synthetic D or L-amino acid esters; (iii) both esters are independently alkyl or aryl esters; and (iv) the 3' ester is independently an alkyl or aryl ester and the 5 '-ester is a natural or synthetic D or L-amino acid ester, wherein the parent drug optionally has an EC50 of less than 10 or 15 micromolar.
- prodrugs falling within the invention are 3'-L-valine ester of ⁇ -D-2',6- dimethyl-cytidine; 3'-L-valine ester of ⁇ -D-2',6-dimethyl-thymidine; 3 '-L- valine ester of ⁇ - D-2',8-dimethyl-adenosine; 3'-L-valine ester of ⁇ -D-2',8-dimethyl-guanosine; 3'-L-valine ester of ⁇ -D-2',6-dimethyl-5-fluorocytidine; 3'-L-valine ester of ⁇ -D-2',6-dimethyl-uridine; 3'-acetyl ester of ⁇ -D-2',6-dimethyl-cytidine; 3'-acetyl ester of ⁇ -D-2',6-dimethyl- thymidine; 3'-acetyl ester of ⁇ -D-2',8
- prodrugs falling within the invention are 3',5'-L-divaline ester of ⁇ -D-2',6-dimethyl-cytidine (dival-2',6-diMe-L-dC); 3',5'-L-divaline ester of ⁇ -D-
- the prodrug of V, 2', 3' or 4 '-branched ⁇ -D or ⁇ -L nucleoside includes biologically cleavable moieties at the 2', 3' and/or 5' positions.
- Prefened moieties are natural or synthetic D or L amino acid esters, including D or L-valyl, though preferably L-amino acid esters, such as L-valyl, and alkyl esters including acetyl.
- this invention specifically includes 2',3'-L or D-diamino acid ester and 2',3',5'- L or D-triamino acid ester of 1', 2', 3' or 4 '-branched ⁇ -D or ⁇ -L nucleosides, prefenably L-amino acid, with any desired purine or pyrimidine base, wherein the parent drug optionally has an EC50 of less than 15 micromolar, and even more preferably less than 10 micromolar; 2',3'-di(alkyl or aryl) ester or 2',3',5'-L-tri(alkyl or aryl) ester of 1', 2', 3' or
- 2',3',5'- triesters of 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleosides wherein (i) all three esters are amino acid esters; (ii) all three esters are independently alkyl or aryl esters; (iii) the 2' ester is an amino acid ester, the 3' ester is an amino acid ester and the 5 '-ester is an alkyl or aryl ester; (iv) the 2' ester is an amino acid ester, the 3' ester is an alkyl or aryl ester and the 5'- ester is an alkyl or aryl ester; (v) the 2' ester is an alkyl or aryl ester, the 3' ester is an alkyl or aryl ester and the 5 '-ester is an amino acid ester; (vi) the 2' ester is an alkyl or aryl ester, the 3' ester is an
- prodrugs falling within the invention include 2',3'-L-divaline ester of ⁇ -D-2',6-dimethyl-cytidine (dival-2',6-diMe-L-dC); 2',3'-L-divaline ester of ⁇ -D-2',6- dimethyl-thymidine; 2',3'-L-divaline ester of ⁇ -D-2',8-dimethyl-adenosine; 2',3'-L-divaline ester of ⁇ -D-2',8-dimethyl-guanosine; 2',3'-L-divaline ester of ⁇ -D-2',6-dimethyl-5-fluoro- cytidine; 2',3'-L-divaline ester of ⁇ -D-2',6-dimethyl-uridine; 2',3 '-diacetyl ester of ⁇ -D-D-
- prodrugs falling within the invention include 2',3',5'-L- trivaline ester of ⁇ -D-2',6-dimethyl-cytidine (trival-2',6-diMe-L-dC); 2',3',5'-L-trivaline ester of ⁇ -D-2',6-dimethyl-thymidine; 2',3',5'-L-trivaline ester of ⁇ -D-2',8-dimethyl- adenosine; 2',3',5'-L-trivaline ester of ⁇ -D-2',8-dimethyl-guanosine; 2',3',5'-L-trivaline ester of ⁇ -D-2',6-dimethyl-5-fluoro-cytidine; 2',3',5'-L-trivaline ester of ⁇ -D-2',6- dimethyl-uridine; 2',3',5'-triacet
- a compound of Formula (I) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (I):
- R 1 , R 2 and R 3 are independently H, phosphate (including mono-, di- or triphosphate and a stabilized phosphate); straight chained, branched or cyclic alkyl (including lower alkyl); acyl (including lower acyl); CO-alkyl, CO-aryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO- substituted aryl, sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl and benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl given herein; alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, a lipid, including a phospholipid; an amino acid; and amino acid residue, a carbohydrate; a peptide; cholesterol; or other pharmaceutically acceptable leaving group
- R 1 , R 2 and/or R 3 may be a pharmaceutically acceptable leaving group which is capable of providing a compound wherein R 1 , R 2 and/or
- R 3 is independently H or phosphate (including mono-, di- or triphosphate), for example when administered in vivo.
- a compound of Formula (II) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (II):
- a compound of Formula (III), (IV) or (V), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric, or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (III), (IV) or (V):
- Base is selected from the group consisting of
- R 1 , R 2 R 3 ' R 4 , and R 5 are as defined above; each W 1 , W 2 , W 3 and W 4 is independently N, CH, CF, CI, CBr, CCl, CCN, CCH 3 , CCF 3 ,
- each W* is independently O, S, NH or NR 4 ;
- X is O, S, SO 2 , CH 2 , CH 2 OH, CHF, CF 2 , C(Y 3 ) 2 , CHCN, C(CN) 2 , CHR 4 or C(R 4 ) 2 ;
- X* is CH, CF, CY 3 or CR 4 ;
- X 2 is H, straight chained, branched or cyclic optionally substituted alkyl, CH 3 , CF 3 , C(Y 3 ) 3 , 2-Br-ethyl, CH 2 F, CH 2 C1, CH 2 CF 3 , CF 2 CF 3 , C(Y 3 ) 2 C(Y 3 ) 3 , CH 2 OH, optionally substituted alkenyl, optionally substituted alkynyl, COOH, COOR 4 , COO-alkyl, COO-aryl, CO- Oalkoxyalkyl, CONH 2 , CONHR 4 , CON(R 4 ) 2 , chloro, bromo, fluoro, iodo, CN, N 3 , OH,
- each X 3 is independently a straight chained, branched or cyclic optionally substituted alkyl (including lower alkyl), CH 3 , CH 2 CN, CH 2 N 3 , CH 2 NH 2 , CH 2 NHCH 3 , CH 2 N(CH 3 ) 2 , CH 2 OH, halogenated alkyl (including halogenated lower alkyl), CF 3 , C(Y 3 ) 3 , 2-Br-ethyl, CH 2 F, CH 2 C1, CH 2 CF 3 , CF 2 CF 3 , C(Y 3 ) 2 C(Y 3 ) 3 , optionally substituted alkenyl, haloalkenyl,
- Y 1 is hydrogen, bromo, chloro, fluoro, iodo, CN, OH, OR 4 , NH 2 , NHR 4 , NR 4 R 5 , SH or SR 4 ; each Y 2 is independently O, S, NH or NR 4 ; each Y 3 is independently H, F, Cl, Br or I; wherein for Base (B), W 4 cannot be CH if W 1 , W 2 and W 3 are N; wherein for Base (E), (F), (K), (L), (W) and (X), W 4 cannot be CH if W 1 is N; each R 6 is independently an optionally substituted alkyl (including lower alkyl), CH 3 ,
- CH 2 CN CH 2 N 3 , CH 2 NH 2 , CH 2 NHCH 3 , CH 2 N(CH 3 ) 2 , CH 2 OH, halogenated alkyl (including halogenated lower alkyl), CF 3 , C(Y 3 ) 3 , 2-Br-ethyl, CH 2 F, CH 2 C1, CH 2 CF 3 ,
- a compound of Formula (VI) or (VII), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or (VII):
- R 8 in Formula (VI) is -OH or -NH 2 only when X is carbon; and wherein; each R 8 and R 11 is independently hydrogen, an optionally substituted alkyl (including lower alkyl), CH 3 , CH 2 CN, CH 2 N 3 , CH 2 NH 2 , CH 2 NHCH 3 , CH 2 N(CH 3 ) 2 , CH 2 OH, halogenated alkyl (including halogenated lower alkyl), CF 3 , C(Y 3 ) 3 , 2-Br-ethyl, CH 2 F, CH 2 C1, CH 2 CF 3 , CF 2 CF 3 , C(Y 3 ) 2 C(Y 3 ) 3 , optionally substituted alkenyl, haloalkenyl, Br-vinyl, optionally substituted alkynyl, haloalkynyl, -CH 2 C(O)OH, -CH 2 C(O)OR 4
- a compound of Formula (VIII), (IX) or (X), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VIII), (DQ or (X):
- each R 12 is independently a substituted alkyl (including lower alkyl), CH 2 CN, CH 2 N 3 , CH 2 NH 2 , CH 2 NHCH 3 , CH 2 N(CH 3 ) 2 , CH 2 OH, halogenated alkyl (including halogenated lower alkyl), CF 3 , C(Y 3 ) 3 , 2-Br-ethyl, CH 2 F, CH 2 C1, CH 2 CF 3 , CF 2 CF 3 , C(Y 3 ) 2 C(Y 3 ) 3 , substituted alkenyl, haloalkenyl
- a compound of Formula (XI) or (XII), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (XI) or (XII):
- Base Base*, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 12 , R 13 , Y, Y 1 , Y 2 , Y 3 , W * , W 1 , W 2 , W 3 , W 4 , X, X*, X 1 ,
- X 2 , and X 3 are as defined above; wherein, in one embodiment, R 8 in Formula (XI) is -OH or -NH 2 only when X is carbon; and wherein; 2004/002999
- each R 8 and R 11 is independently hydrogen, an optionally substituted alkyl (including lower alkyl), CH 3 , CH 2 CN, CH 2 N 3 , CH 2 NH 2 , CH 2 NHCH 3 , CH 2 N(CH 3 ) 2 , CH 2 OH, halogenated alkyl (including halogenated lower alkyl), CF 3 , C(Y 3 ) 3 , 2-Br-ethyl, CH 2 F, CH 2 C1, CH 2 CF 3 , CF 2 CF 3 , C(Y 3 ) 2 C(Y 3 ) 3 , optionally substituted alkenyl, haloalkenyl, Br-vinyl, optionally substituted alkynyl, haloalkynyl, -CH 2 C(0)OH, -CH 2 C(O)OR 4 , -CH 2 C(0)0(lower alkyl),
- R 8 and R 13 , R 9 and R 13 , R 9 and R 11 or R 10 and R 12 can come together to form a bridged compound selected from the group consisting of optionally substituted carbocycle (preferably a 3-7 membered carbocyclic ring) or optionally substituted heterocycle (preferably a 3-7 membered heterocyclic ring having one or more O, S and/or N); or alternatively, R 12 and R 13 or R 9 and R 10 can come together to form a spiro compound selected from the group consisting of optionally substituted carbocycle (preferably a 3-7 membered carbocyclic ring) or optionally substituted heterocycle (preferably
- a compound of Formula (XI) or (XII), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (XI) or (XII):
- R 3 is selected from the group consisting of H; mono-, di-, and tri-phosphate or a stabilized phosphate prodrug; acyl; a sulfonate ester; optionally substituted alkyl sulfonyl; optionally substituted arylsulfonyl; a lipid; an amino acid; a carbohydrate; a peptide; cholesterol; and a pharmaceutically acceptable leaving group which when administered in vivo is capable of providing a compound wherein R 3 is independently H, or mono-, di- or triphosphate; X" is selected from the group consisting of one or more O, S, SO, S0 2 , N, NH, NR and CH 2 wherein any of the aforementioned may be optionally substituted and may be variably positioned so as to form a 3-7 membered ring;
- R is H, alkyl or acyl
- B indicates a spiro compound selected from the group consisting of optionally substituted carbocycle (preferably a 3-7 membered carbocyclic ring) or optionally substituted heterocycle (preferably a 3-7 membered heterocyclic ring having one or more O, S and/or
- Base is selected from the group consisting of:
- each R', R", R'" and R" are independently selected from the group consisting of
- H OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH 2 , NH-alkyl, N-dialkyl, NH-acyl, N-aryl, N-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-acyl, S-aryl, S- cycloalkyl, S-aralkyl, F, Cl, Br, I, CN, COOH, CONH* C0 2 -alkyl, CONH-alkyl, CON-dialkyl, OH, CF 3 , CH 2 OH, (CH 2 ) m OH, (CH 2
- T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* or N;
- Q and Q 2 independently are N or C-R;
- Q 3; Q 4 , Q 5 and Q 6 independently are N or CH; and tautomeric forms thereof.
- a compound of Formula (XV), (XVI) or (XVII), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (XV), (XVI) or (XVII):
- R is H, alkyl or acyl; and R', R", R'", R"", and R 3 and Base are as defined for Formula (XIII).
- At most one of G and E can further be hydrogen.
- a compound of Formula (XVIII) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a
- a compound of Formula (XIX), (XX), (XXI) (XXII) or (XXIII) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (XIX), (XX), (XXI) (XXII) or (XXIII):
- A is selected from the group consisting of optionally substituted lower alkyl, cycloalkyl, alkenyl, alkynyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3, CF 2 CF 3 , CH 2 CO 2 R, (CH 2 ) m COOH, (CH 2 ) m COOR, (CH 2 ) m CO- NH* (CH 2 ) m CONR* and (CH 2 ) m CONHR;
- Y is selected from the group consisting of H, optionally substituted lower alkyl, cycloalkyl, alkenyl, alkynyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3, CF 2 CF 3 , CH 2 CO 2 R, (CH 2 ) m COOH, (CH 2 ) m COOR, (CH 2 ) m CONH* (CH 2 ) m CONR 2 , and (CH 2 ) m CONHR;
- X is selected from the group consisting of -OH, optionally substituted alkyl, cycloalkyl, alkenyl, alkynyl, -O-alkyl, -O-alkenyl, -O-alkynyl, -O-aryl, -O-aralkyl, -O-cycloal
- R is H, alkyl or acyl
- R 3 is selected from the group consisting of H; mono-, di-, and tri-phosphate or a stabilized phosphate prodrug; substituted or unsubstituted alkyl; acyl; a sulfonate ester; optionally substituted alkyl sulfonyl; optionally substituted arylsulfonyl; a lipid; an amino acid; a carbohydrate; a peptide; cholesterol; and a pharmaceutically acceptable leaving group which when administered in vivo is capable of providing a compound wherein R 3 is independently H, or mono-, di- or triphosphate; and Base is a non-natural base selected from the group of:
- each R', R", R'" and R"" is independently selected from the group consisting of H, OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH 2 , NH-alkyl, N-dialkyl,
- W is C-R" orN; T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* orN;
- Qi and Q 2 independently are N or C-R"";
- Q 3 , Q 4 , Q 5 and Q 6 independently are N or CH; with the proviso that in bases (g) and (i), R', R"" are not H, OH, or NH 2 ; and Q,
- T, V, Q* Q5 and Q 6 are not N.
- the amino acid residue is of the formula C(0)C(R ⁇ )(R 12 )(NR 13 R 14 ), wherein:
- R 11 is the side chain of an amino acid and wherein, as in proline, R 11 can optionally be attached to R 13 to form a ring structure; or alternatively, R n is an alkyl, aryl, heteroaryl or heterocyclic moiety;
- R 12 is hydrogen, alkyl (including lower alkyl) or aryl
- R 13 and R 14 are independently hydrogen, acyl (including an acyl derivative attached to R 11 ) or alkyl (including but not limited to methyl, ethyl, propyl, and cyclopropyl).
- at least one of R 2 and R 3 is an amino acid residue, and is preferably L-valinyl.
- the ⁇ -D- and ⁇ -L-nucleosides of this invention may inhibit Flaviviridae polymerase activity.
- Nucleosides can be screened for their ability to inhibit Flaviviridae polymerase activity in vitro according to screening methods set forth more particularly herein. One can readily determine the spectrum of activity by evaluating the compound in the assays described herein or with another confirmatory assay.
- the efficacy of the anti-Flaviviridae compound is measured according to the concentration of compound necessary to reduce the plaque number of the virus in vitro, according to methods set forth more particularly herein, by 50% (i.e. the compound's ECso).
- the parent of the prodrug compound exhibits an EC 50 of less than 25, 15, 10, 5, or 1 micromolar.
- the compound exhibits an EC50 of less than 15 or 10 micromolar, when measured according to the polymerase assay described in Fenari et al, Jnl of Vir., 73:1649-1654, 1999; Ishii et al, Hepatology, 29:1227-1235,1999; Lohmann et al, Jnl. of Bio. Chem., 274:10807-10815, 1999; or Yamashita et al, Jnl. of Bio. Chem., 273:15479-15486, 1998.
- combination and/or alternation therapy are provided.
- an effective dosage of two or more agents are administered together, whereas during alternation therapy an effective dosage of each agent is administered serially.
- the dosages will depend on absorption, inactivation, and excretion rates of the drug as well as other factors known to those of skill in the art. It is to be noted that dosage values will also vary with the severity of the condition to be alleviated. It is to be further understood that for any particular subject, specific dosage regimens and schedules should be adjusted over time according to the individual need and the professional judgment of the person administering or supervising the administration of the compositions.
- the invention provides combinations of at least two of the herein described prodrugs.
- the invention further provides at least one of the described 2' and 3'-prodrugs in combination or alternation with a second nucleoside that exhibits activity against a Flaviviridae, including but not limited to a parent drug of any of the prodrugs defined herein, i.e.
- the 2' or 3'-prodrugs can be administered in combination or alternation with other anti-Flaviviridae agent exhibits an EC 5 0 of less than 10 or 15 micromolar, or their prodrugs or pharmaceutically acceptable salts.
- Nonlimiting examples of antiviral agents that can be used in combination with the compounds disclosed herein include: 1) an interferon and/or ribavirin; (2) Substrate-based NS3 protease inhibitors;. (3) Non-substrate-based inhibitors; (4) Thiazolidine derivatives; (5) Thiazolidines and benzanilides; (6) A phenan-threnequinone; (7) NS3 inhibitors; (8) HCV helicase inhibitors; (9) polymerase inhibitors, including RNA-dependent RNA- polymerase inhibitors; (10) Antisense oligodeoxynucleotides; (11) Inhibitors of IRES- dependent translation; (12) Nuclease-resistant ribozymes; and (13) other compounds that exhibit activity against a flaviviridae.
- the invention further includes administering the prodrug in combination or alternation with an immune modulator or other pharmaceutically active modifer of viral replication, including a biological material such as a protein, peptide, oligonucleotide, or gamma globulin, including but not limited to interfereon, interleukin, or an antisense oligonucleotides to genes which express or regulate Flaviviridae replication.
- an immune modulator or other pharmaceutically active modifer of viral replication including a biological material such as a protein, peptide, oligonucleotide, or gamma globulin, including but not limited to interfereon, interleukin, or an antisense oligonucleotides to genes which express or regulate Flaviviridae replication.
- the invention further includes administering the prodrug in combination or alternation with an immune modulator or other pharmaceutically active modifer of viral replication, including a biological material such as a protein, peptide, oligonucleotide, or gamma globulin, including but not limited to interfereon, interleukin, or an antisense oligonucleotides to genes which express or regulate Flaviviridae replication.
- an immune modulator or other pharmaceutically active modifer of viral replication including a biological material such as a protein, peptide, oligonucleotide, or gamma globulin, including but not limited to interfereon, interleukin, or an antisense oligonucleotides to genes which express or regulate Flaviviridae replication.
- an immune modulator or other pharmaceutically active modifer of viral replication including a biological material such as a protein, peptide, oligonucleotide, or gamma globulin, including but not limited to interfere
- compositions comprising a compound of Formula (XIII) - (XXIII), or its pharmaceutically acceptable salt or prodrug thereof, together with a pharmaceutically acceptable canier or dileuent;
- compositions comprising a compound of Formula (XIII) - (XXIII), or its pharmaceutically acceptable salt or prodrug thereof, with one or more other effective antiviral agent, optionally with a pharmaceutically acceptable canier or dileuent;
- pharmaceutical compositions for the treatment of a Flaviviridae infection in a host comprising a compound of Formula (I) - (XXIII), or its pharmaceutically acceptable salt or prodrug thereof, together with a pharmaceutically acceptable canier or dileuent;
- compositions for the treatment of a Flaviviridae infection in a host comprising a compound of Formula (I) - (XXIII), or its pharmaceutically acceptable salt or prodrug thereof, with one or more other effective antiviral agent, optionally with a pharmaceutically acceptable carrier or dileuent;
- (j) uses for a compound of Formula (I) - (XXIII), or its pharmaceutically acceptable salt or prodrug thereof, optionally with a pharmaceutically acceptable canier or dileuent, in the manufacture of a medicament for the treatment of a Flaviviridae infection in a host; and (k) uses for a compound of Formula (I) - (XXIII), or its pharmaceutically acceptable salt or prodrug thereof, with one or more other effective antiviral agent, optionally with a pharmaceutically acceptable canier or dileuent, in the manufacture of a medicament for the treatment of a Flaviviridae infection in a host.
- the parent nucleoside compound of any of the 2'- or 3'- prodrugs are provided for the treatment of a Flaviviridae infection and in particular a hepatitis C infection.
- Figure 1 provides the structure of various non-limiting examples of nucleosides of the present invention, as well as other known nucleosides, in particular FIAU and ribavirin.
- Figure 2 provides a non-limiting example of the steps involved in esterification of the V, 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside to obtain a 2'-prodrug.
- the same general procedure can be used to obtain the 3 '-prodrug by selectively protecting the 2' and 5 '-hydroxyl groups or protecting the 2', 3' and 5 '-hydroxyl groups and selectively deprotecting the 3 ' -hydroxyl.
- Figure 3 provides a non-limiting example of the steps involved in esterification of the 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside to obtain a 3 '-prodrug.
- Figure 4 provides a non-limiting example of the steps involved in esterification of the 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside to obtain a 2',3 '-prodrug.
- the invention as disclosed herein is a compound, a method and composition for the treatment of a Flaviviridae infection in humans and other host animals.
- the method includes the administration of an effective anti-Flaviviridae treatment amount of a 2' and/or 3 '-prodrug of a 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside as described herein or a pharmaceutically acceptable salt, derivative or prodrug thereof, optionally in a pharmaceutically acceptable canier.
- the compounds of this invention either possesses antiviral (i.e., anti-HCV) activity, or are metabolized to a compound that exhibits such activity.
- HCV is a member of the Flaviviridae family.
- the Flaviviridae has been placed in a new monotypic genus, hepacivirus. Therefore, in one embodiment, the Flaviviridae is HCV. In an alternate embodiment, the Flaviviridae is a flavivirus or pestivirus.
- the 2' and/or 3 '-prodrugs of a 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside are acyl derivates of a secondary or tertiary alcohol alpha to a secondary or tertiary carbon. Due to the steric hindrance of these prodrugs over the 5 '-prodrugs, an acyl derivative of a primary alcohol, these prodrugs differentially modulate the biological properties of the molecule in vivo.
- the 2' and/or 3'-prodrugs of a V, , 3' or 4'- branched ⁇ -D or ⁇ -L nucleoside can provide a drug with increased half-life and improved pharmacokinetic profile.
- the 2' or 3 '-prodrug in a preferred embodiment is a cleavable acyl group, and most particularly, an amino acid moiety, prepared from any naturally occurring and synthetic ⁇ , ⁇ ⁇ or ⁇ amino acid, including but is not limited to, glycine, alanine, valine, leucine, isoleucine, methionine, phenylalanine, tryptophan, proline, serine, threonine, cysteine, tyrosine, asparagine, glutamine, aspartate, glutamate, lysine, arginine and histidine.
- the amino acid is in the L-configuration.
- the amino acid can be a derivative of alanyl, valinyl, leucinyl, isoleuccinyl, prolinyl, phenylalaninyl, tryptophanyl, methioninyl, glycinyl, serinyl, threoninyl, cysteinyl, tyrosinyl, asparaginyl, glutaminyl, aspartoyl, glutaroyl, lysinyl, argininyl, histidinyl, ⁇ -alanyl, ⁇ -valinyl 5 ⁇ - leucinyl, ⁇ -isoleuccinyl, ⁇ -prolinyl, ⁇ -phenylalaninyl, ⁇ -tryptophanyl, ⁇ -methioninyl, ⁇ - glycinyl, ⁇ -serinyl, ⁇ -threoninyl, ⁇ -cysteiny
- the oral bio-availability of 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside as the neutral base and the HCl salt is low in rodents and non-human primates. It has been discovered that there is significant competition of V, , 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside with other nucleosides or nucleoside analogs for absorption, or transport, from the gastrointestinal tract and competition of other nucleosides or nucleoside analogs for the absorption with 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside.
- 2' and 3 '-prodrugs of 1', 2 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside were obtained with higher oral bioavailability than the parent molecule and a reduced effect on the bioavailability of other nucleosides or nucleoside analogs used in combination.
- the 2', 3', and/or 5'-mono, di or frivaline ester of a 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside have higher oral bioavailability than the parent 1', 2', 3' or 4 '-branched ⁇ -D or ⁇ -L nucleoside and reduced interaction with other nucleosides or nucleoside analogs when used in combination as compared to V, 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside.
- the 2', 3', and/or 5'-mono, di or trivaline ester of a 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside can be converted to the parent V, 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside through de-esterification in the gastrointestinal mucosa, blood or liver.
- the 2', 3', and/or 5'-mono, di or trivaline ester of a 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside can be converted to the parent V, 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside through de-esterification in the gastrointestinal mucosa, blood or liver.
- 3', and/or 5 '-mono, di or trivaline ester of a 1', 2', 3' or 4 '-branched ⁇ -D or ⁇ -L nucleoside can be actively transported from the gastrointestinal lumen after oral delivery into the bloodstream by an amino acid transporter function in the mucosa of the gastrointestinal tract. This accounts for the increase in oral bioavailability compared to the parent 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside that is transported primarily by a nucleoside transporter function.
- the present invention includes the following features:
- compositions comprising a 2' and/or 3 '-prodrug of a 1', 2', 3' or 4'- branched ⁇ -D or ⁇ -L nucleoside or a pharmaceutically acceptable salt thereof together with one or more other effective anti-HCV agents, optionally in a pharmaceutically acceptable canier or diluent;
- compositions comprising a 2' and/or 3'-prodrug of a 1', 2', 3' or 4'- branched ⁇ -D or ⁇ -L nucleoside or a pharmaceutically acceptable salt thereof together with the parent of a different a V, 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside, optionally in a pharmaceutically acceptable carrier or diluent;
- a method for the treatment and/or prophylaxis of a host infected with Flaviviridae that includes the administration of an effective amount of a 2' and/or 3 '-prodrug of a 1', 2', 3' or 4 '-branched ⁇ -D or ⁇ -L nucleoside, its pharmaceutically acceptable salt or composition in combination and/or alternation with one or more effective anti- HCV agent;
- (k) a method for the treatment and/or prophylaxis of a host infected with Flaviviridae that includes the administration of an effective amount of a 2' and/or 3 '-prodrug of a ⁇ -D-2'-methyl-cytidine, or its pharmaceutically acceptable salt or composition thereof; (1) a method for the treatment and/or prophylaxis of a host infected with Flaviviridae that includes the administration of an effective amount of the 2'-valyl or acetyl ester of ⁇ -D-2'-methyl-cytidine, or its pharmaceutically acceptable salt or composition thereof; (m) use of a 2' and/or 3'-prodrug of a 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside, and pharmaceutically acceptable salts and compositions thereof for the treatment and/or prophylaxis of a Flaviviridae infection in a host; (n) use of a 2' and
- Flaviviridae infection in a host (o) use of a 2' and/or 3'-prodrug of a V, 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside, or its pharmaceutically acceptable salt or composition with the parent of a different a 1 ', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside for the treatment and/or prophylaxis of a Flaviviridae infection in a host; (p) use of a 2' and/or 3 '-prodrug of a ⁇ -D-2 '-methyl-cytidine, or its pharmaceutically acceptable salt or composition thereof for the treatment and/or prophylaxis of a
- Flaviviridae infection in a host (q) use of the 3'-valyl or acetyl ester of ⁇ -D-2 '-methyl-cytidine, or its pharmaceutically acceptable salt or composition thereof for the treatment and/or prophylaxis of a
- Flaviviridae infection in a host (r) use of a 2' and/or 3'-prodrug of a V, 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleoside, and pharmaceutically acceptable salts and compositions thereof in the manufacture of a medicament for treatment and/or prophylaxis of a Flaviviridae infection;
- Flaviviridae included within the scope of this invention are discussed generally in Fields Virology, Editors: Fields, B. N., Knipe, D. M., and Howley, P. M., Lippincott-Raven Publishers, Philadelphia, PA, Chapter 31, 1996.
- the Flaviviridae is HCV.
- the Flaviviridae is a flavivirus or pestivirus. Specific flaviviruses include, without limitation:
- Pestiviruses included within the scope of this invention are discussed generally in Fields Virology, Editors: Fields, B. N., Knipe, D. M., and Howley, P. M., Lippincott-Raven Publishers, Philadelphia, PA, Chapter 33, 1996.
- Specific pestiviruses include, without limitation: bovine viral dianhea virus (“BVDV”), classical swine fever virus (“CSFV,” also called hog cholera virus), and border disease virus (“BDV”).
- BVDV bovine viral dianhea virus
- CSFV classical swine fever virus
- BDV border disease virus
- a compound of Formula (I), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (I):
- R 1 , R 2 and R 3 are independently H, phosphate (including mono-, di- or triphosphate and a stabilized phosphate); straight chained, branched or cyclic alkyl (including lower alkyl); acyl (including lower acyl); CO-alkyl, CO-aryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO- substituted aryl, sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl and benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl given herein; alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, a lipid, including a phospholipid; an amino acid; and amino acid residue, a carbohydrate; a peptide; cholesterol; or other pharmaceutically acceptable leaving group
- Y 1 is hydrogen, bromo, chloro, fluoro, iodo, CN, OH, OR 4 , NH* NHR 4 , NR 4 R 5 , SH or SR 4 ;
- X 1 is a straight chained, branched or cyclic optionally substituted alkyl, CH 3 , CF 3 , C(Y 3 ) 3 , 2-Br-ethyl, CH 2 F, CH 2 C1, CH 2 CF 3 , CF 2 CF 3 , C(Y 3 ) 2 C(Y 3 ) 3 , CH 2 OH, optionally substituted alkenyl, optionally substituted alkynyl, COOH, COOR 4 , COO-alkyl, COO-aryl, CO- Oalkoxyalkyl, CONH* CONHR 4 , CON(R 4 )* chloro, bromo, fluoro, iodo, CN, N 3s OH,
- X 2 is H, straight chained, branched or cyclic optionally substituted alkyl, CH 3 , CF 3 , C(Y 3 ) 3 , 2-Br-ethyl, CH 2 F, CH 2 C1, CH 2 CF 3 , CF 2 CF 3 , C(Y 3 ) 2 C(Y 3 ) 3 , CH 2 OH, optionally substituted alkenyl, optionally substituted alkynyl, COOH, COOR 4 , COO-alkyl, COO-aryl, CO- Oalkoxyalkyl, CONH* CONHR 4 , CON(R 4 )* chloro, bromo, fluoro, iodo, CN, N 3 , OH,
- each Y 3 is independently H, F, Cl, Br or I; each R 4 and R 5 is independently hydrogen, acyl (including lower acyl), alkyl (including but not limited to methyl, ethyl, propyl and cyclopropyl), lower alkyl, alkenyl, alkynyl or cycloalkyl.
- a compound of Formula (I) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (I) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof, wherein:
- R 1 is H or phosphate (preferably H);
- R 2 and R 3 are independently H, phosphate, acyl or an amino acid residue, wherein at least one of R 2 and R 3 is acyl or an amino acid residue;
- X 1 is CH 3 , CF 3 or CH 2 CH 3 ;
- X 2 is H orNH 2 ;
- Y is hydrogen, bromo, chloro, fluoro, iodo, NH or OH.
- a compound of Formula (II) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (II):
- a compound of Formula (II), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (II) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof, wherein: R 1 is H or phosphate (preferably H);
- R 2 and R 3 are independently H, phosphate, acyl or an amino acid residue, wherein at least one of R 2 and R 3 is acyl or an amino acid residue;
- X 1 is CH 3 , CF 3 or CH 2 CH 3 ; 2004/002
- X 2 is H, F, Cl, Br, I or CH 3 ;
- Y is hydrogen, bromo, chloro, fluoro, iodo, NH 2 or OH.
- a compound of Formula (III), (IN) or (V) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (III), (IV), or (V):
- BAA BAB
- BAC BAD
- each W 1 , W 2 , W 3 and W 4 is independently N, CH, CF, CI, CBr, CCl, CCN, CCH 3 , CCF 3 , CCH 2 CH 3 , CC(O)NH 2 , CC(O)NHR 4 , CC(O)N(R 4 )* CC(O)OH, CC(0)OR 4 or CX 3 ; each W* is independently O, S, NH or NR 4 ; wherein for Base (B), W 4 cannot be CH if W 1 , W 2 and W 3 are N; wherein for Base (E), (F), (K), (L), (W) and (X), W 4 cannot be CH if W 1 is N; X is O, S, SO* CH* CH 2 OH, CHF, CF* C(Y 3 )* CHCN, C(CN) 2 , CHR 4 or C(R 4 ) 2 ; X* is CH, CF, CY 3 or
- the compound of Formula (III), (IV) or (V), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof or the method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (III), (IV), or (V) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, wherein:
- R 1 is H or phosphate (preferably H);
- R 2 and R 3 are independently H, phosphate, acyl or an amino acid residue, wherein at least one of R 2 and R 3 is acyl or an amino acid residue;
- W 4 is CX 3 ;
- X 3 is CH 3 , CF 3 or CH 2 CH 3 ;
- R 6 is alkyl
- X is O, S, SO 2 or CH*
- the compound of Formula (III), (IV) or (V), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof or the method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (III), (IV) or (V), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof, is provided, wherein:
- R 1 is H or phosphate (preferably H);
- R 2 and R 3 are independently H, phosphate, acyl or an amino acid residue, wherein at least one of R 2 and R 3 is an amino acid residue;
- W 4 is CX 3 ;
- X 3 is CH 3 , CF 3 or CH 2 CH 3 ;
- R 6 is alkyl
- X is O, S, SO 2 or CH*
- the compound of Formula (III), (IV) or (V), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof or the method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (III), (IV) or (V), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof, is provided, wherein:
- R 1 is H or phosphate (preferably H);
- R 2 and R 3 are independently H, phosphate, acyl or an amino acid residue, wherein at least one of R 2 and R 3 is acyl or an amino acid residue;
- W 4 is CX 3 ;
- X 3 is CH 3 , CF 3 or CH 2 CH 3 ;
- R is alkyl; and X is O.
- the compound of Formula (IV(a)), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof is provided, as well as the method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (IV(a)):
- Base is as defined herein; optionally substituted with an amine or cyclopropyl (e.g., 2- amino, 2,6-diamino or cyclopropyl guanosine);
- an amine or cyclopropyl e.g., 2- amino, 2,6-diamino or cyclopropyl guanosine
- R 7 is halo (F, Cl, Br or I), though preferably F;
- R 1 is H; phosphate (including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug); acyl (including lower acyl); alkyl (including lower alkyl); sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl and benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl given herein; a lipid, including a phospholipid; an amino acid; a carbohydrate; a peptide; cholesterol; or other pharmaceutically acceptable leaving group which when administered in vivo is capable of providing a compound wherein R 1 or R 2 is independently H or phosphate.
- R 2 is not phosphate (including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug); and R 2 is phosphate (including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug); acyl (including lower acyl); alkyl (including lower alkyl); sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl and benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl given herein; a lipid, including a phospholipid; an amino acid; a carbohydrate; a peptide; cholesterol; or other pharmaceutically acceptable leaving group which when administered in vivo is capable of providing a compound wherein R 1 or R 2 is independently H or phosphate.
- R 2 is not phosphate (including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug).
- a compound of Formula (VI) or (VII) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof is provided, as well as a method for the freatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or (VII):
- R 6 and R 7 or R 9 and R 10 can come together to form a spiro compound selected from the group consisting of optionally substituted carbocycle (preferably a 3-7 membered carbocyclic ring) or optionally substituted heterocycle (preferably a 3-7 membered heterocyclic ring having one or more O 5 S and/or N).
- a compound of Formula (VI), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective freatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, in which: • X is O, S, SO or SO 2 ; and/or • each R 6 is independently an optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, CH 2 OH, CH2NH2, CH 2 NHCH 3 , CH 2 N(CH 3 ) 2 , CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3, CF
- each R 7 is independently -OH, optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, -O-alkyl, -O- alkenyl, -O-alkynyl, -O-aralkyl, -O-cycloalkyl-, O-acyl, F, Cl, Br, I, CN, NC, SCN, OCN, NCO, NO* NH* N 3 , NH-acyl, NH-alkyl, N-dialkyl, NH-alkenyl, NH-alkynyl, NH-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-alkenyl, S-alkynyl, S-aralkyl, S-acyl, S- cycloalkyl, CO 2 -alkyl, CONH-alkyl, CON-dialkyl, CONH-alken
- each R 9 is independently hydrogen, optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, - OH, -O-alkyl, -O-alkenyl, -O-alkynyl, -O-aralkyl, -O-cycloalkyl- 5 O-acyl, F, Cl, Br, I,
- CN NC, SCN, OCN, NCO, NO* NH* N 3 , NH-acyl, NH-alkyl, N-dialkyl, NH-alkenyl, NH-alkynyl, NH-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-alkenyl, S-alkynyl, S-aralkyl, S-acyl, S-cycloalkyl, C0 2 -alkyl, CONH-alkyl, CON-dialkyl, CONH-alkenyl, CONH- alkynyl, CONH-aralkyl, CONH-cycloalkyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3> CF 2 CF 3 , CH 2 C0 2 R 4 ,
- each R 10 is independently hydrogen, an optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substimted cycloalkyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3 , CF 2 CF 3 , CH 2 C0 2 R 4 , (CH 2 ) m COOH, (CH 2 )
- each R 8 and R 11 is independently H, CH 3 , CH 2 OH, CH 2 F, CH 2 N 3 , (CH 2 ) m COOH,
- Base is selected from one of the following:
- each R', R", R'" and R" is independently selected from the group consisting of
- H substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH* NH-alkyl, N-dialkyl,
- T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* or N;
- Q and Q 2 independently are N or C-R; wherein R is H, alkyl or acyl;
- Q 3j Q 4 , Q5 and Q 6 independently are N or CH; and tautomeric forms thereof.
- a compound of Formula (VI), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, in which:
- X is O, S 5 SO or S0 2 ;
- R 6 and R 7 come together to form a spiro compound selected from the group consisting of optionally substituted 3-7 membered spiro carbocyclic or heterocyclic compound having one or more N, O and/or S atoms, said heteroatoms independently taken alone or in combination with one another; and/or
- each R 9 is independently hydrogen, optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, - OH, -O-alkyl, -O-alkenyl, -O-alkynyl, -O-aralkyl, -O-cycloalkyl-, O-acyl, F, C Br, I,
- CN NC, SCN, OCN, NCO, NO* NH* N 3 , NH-acyl, NH-alkyl, N-dialkyl, NH-alkenyl, NH-alkynyl, NH-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-alkenyl, S-alkynyl 5 S-aralkyl, S-acyl, S-cycloalkyl, CO 2 -alkyl, CONH-alkyl, CON-dialkyl, CONH-alkenyl, CONH- alkynyl, CONH-aralkyl, CONH-cycloalkyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3s CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3 , CF 2 CF 3 , CH 2 CO 2 R 4 ,
- each R 10 is independently hydrogen, an optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3, CF 2 CF 3 , CH 2 C0 2 R 4 , (CH 2 ) m COOH, (CH 2 ) m COOR 4 ,
- each m is independently 0 or 1 ; and/or Base is selected from one of the following:
- each R', R", R'" and R" is independently selected from the group consisting of
- H substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH* NH-alkyl, N-dialkyl,
- W is C-R" or N
- T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* or N;
- Qj and Q 2 independently are N or C-R; wherein R is H, alkyl or acyl;
- Q 3; Q 4 , Q 5 and Q 6 independently are N or CH; and tautomeric forms thereof.
- a compound of Formula (VI), or its pharmaceutically acceptable salt or prodrug thereof, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which:
- X is O, S, SO or SO 2 ;
- each R 6 is independently an optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, CH 2 OH,
- each R 7 is independently -OH, optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, -O-alkyl, -O- alkenyl, -O-alkynyl, -O-aralkyl, -O-cycloalkyl-, O-acyl, F, Cl, Br, I, CN, NC, SCN, OCN, NCO, NO* NH* N 3 , NH-acyl, NH-alkyl, N-dialkyl, NH-alkenyl, NH-alkynyl, NH-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-alkenyl, S-alkynyl, S-aralkyl, S-acyl, S- cycloalkyl, CO 2 -alkyl, CONH-alkyl, CON-dialkyl, CONH-alken
- R 9 and R 10 come together to form a spiro compound selected from the group consisting of optionally substituted 3-7 membered spiro carbocyclic or heterocyclic compound having one or more N, O and/or S atoms, said heteroatoms independently taken alone or in combination with one another; and/or • each R 8 and R 11 is independently H, CH 3 , CH 2 OH, CH 2 F, CH 2 N 3 , (CH 2 ) m COOH,
- each m is independently 0 or 1 ;
- Base is selected from one of the following: wherein: each R', R", R'" and R"" is independently selected from the group consisting of H, OH, substimted or unsubstituted alkyl, substimted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH* NH-alkyl, N-dialkyl,
- W is C-R" orN
- T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* or N;
- Qi and Q 2 independently are N or C-R; wherein R is H, alkyl or acyl;
- a compound of Formula (VI), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which:
- R 6 and R 7 come together to form a spiro compound selected from the group consisting of optionally substituted 3-7 membered spiro carbocyclic or heterocyclic compound having one or more N, O and/or S atoms, said heteroatoms independently taken alone or in combination with one another; and/or
- R 9 and R 10 come together to form a spiro compound selected from the group consisting of optionally substituted 3-7 membered spiro carbocyclic or heterocyclic compound having one or more N, O and/or S atoms, said heteroatoms independently taken alone or in combination with one another; and/or
- each R 8 and R n is independently H, CH 3 , CH 2 OH, CH 2 F, CH 2 N 3 , (CH 2 ) m COOH, (CH 2 ) m COOR 4 , (CH 2 ) m CONH* (CH 2 ) m CON(R 4 )* (CH 2 ) m CONHR 4 andN-acyl; and/or
- each m is independently 0 or 1 ; and/or • Base is selected from one of the following:
- each R', R", R'" and R"" is independently selected from the group consisting of H, OH, substimted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, 0-cycloalkyl, NH* NH-alkyl, N-dialkyl, NH-acyl, N-aryl, N-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-acyl, S-aryl, S- 2004/002999
- W is C-R" orN; T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* orN;
- Q ⁇ and Q 2 independently are N or C-R; wherein R is H, alkyl or acyl;
- Q 3; Q 4 , Q 5 and Q 6 independently are N or CH; and tautomeric forms thereof.
- a compound of Formula (VI), or its pharmaceutically acceptable salt or prodrug thereof, or a stereoisomeric, tautomeric or polymorphic form thereof as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof, is provided, in which:
- X is CH* CH 2 OH, CHF, CF* C(Y 3 )* CHCN, C(CN)* CHR 4 or C(R ) 2 ;
- each R 6 is independently an optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, CH 2 OH, CH 2 NH 2 , CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3,
- each R 7 is independently -OH, optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, -O-alkyl, -O- alkenyl, -O-alkynyl, -O-aralkyl, -O-cycloalkyl-, O-acyl, F, Cl, Br, I, CN, NC, SCN,
- NCO NO* NH* N 3 , NH-acyl, NH-alkyl, N-dialkyl, NH-alkenyl, NH-alkynyl, NH-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-alkenyl, S-alkynyl, S-aralkyl, S-acyl, S- cycloalkyl, C0 2 -alkyl, CONH-alkyl, CON-dialkyl, CONH-alkenyl, CONH-alkynyl, CONH-aralkyl, CONH-cycloalkyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3 , CF 2 CF 3 , CH 2 CO 2 R 4 , (CH 2 ) m COOH,
- heterocyclic ring having O, S and/or N independently as a heteroatom taken alone or in combination;
- each R 9 is independently hydrogen, optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, - OH, -O-alkyl, -O-alkenyl, -O-alkynyl, -O-aralkyl, -O-cycloalkyl-, O-acyl, F, Cl, Br, I,
- CN NC, SCN, OCN, NCO, NO* NH* N 3 , NH-acyl, NH-alkyl, N-dialkyl, NH-alkenyl, NH-alkynyl, NH-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-alkenyl, S-alkynyl, S-aralkyl, S-acyl, S-cycloalkyl, C0 2 -alkyl, CONH-alkyl, CON-dialkyl, CONH-alkenyl, CONH- alkynyl, CONH-aralkyl, CONH-cycloalkyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3, CF 2 CF 3 , CH 2 CO 2 R 4 ,
- each R 10 is independently hydrogen, an optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3, CF 2 CF 3 , CH 2 C0 2 R 4 , (CH 2 ) m COOH, (CH 2 ) m COOR 4 , (CH 2 ) m CONH* (CH 2 ) m CON(R 4 ) 2 , (CH 2 ) m CONHR 4 , an optionally substimted 3-7 membered carbocyclic, and an optionally substituted 3-7 membered heterocyclic ring having O, S and/or N independently as a heteroatom taken alone or in combination; and/or • each R 10 is independently hydrogen, an optionally substituted lower alkyl,
- each m is independently 0 or 1 ;
- Base is selected from one of the following:
- each R', R", R'" and R"" is independently selected from the group consisting of H, OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substimted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH* NH-alkyl, N-dialkyl,
- W is C-R" orN
- T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* or N;
- Qi and Q 2 independently are N or C-R;
- Q 3; Q 4 , Q 5 and Q 6 independently are N or CH; and tautomeric forms thereof.
- a compound of Formula (VI), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof as well as a method for the freatment of a host infected with a
- Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which: 2004/002999
- X is CH* CH 2 OH, CHF, CF* C(Y 3 )* CHCN, C(CN)* CHR 4 or C(R 4 ) 2 ;
- R 6 and R 7 come together to form a spiro compound selected from the group consisting of optionally substimted 3-7 membered spiro carbocyclic or heterocyclic compound having one or more N, O and/or S atoms, said heteroatoms independently taken alone or in combination with one another; and/or
- each R 9 is independently hydrogen, optionally substituted lower alkyl, optionally substimted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, - OH, -O-alkyl, -O-alkenyl, -O-alkynyl, -O-aralkyl, -O-cycloalkyl-, O-acyl, F, Cl, Br, I, CN, NC, SCN, OCN, NCO, NO* NH* N 3 , NH-acyl, NH-alkyl, N-dialkyl, NH-alkenyl, NH-alkynyl, NH-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-alkenyl, S-alkynyl, S-aralkyl,
- each R 10 is independently hydrogen, an optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 ,
- each R 8 and R 11 is independently H, CH 3 , CH 2 OH, CH 2 F, CH 2 N 3 , (CH 2 ) m COOH, (CH 2 ) m COOR 4 , (CH 2 ) m CONH* (CH 2 ) m CON(R 4 ) 2 , (CH 2 ) m CONHR 4 andN-acyl; and/or • each m is independently 0 or 1; and/or
- Base is selected from one of the following:
- each R', R", R'" and R"" is independently selected from the group consisting of H, OH, substituted or unsubstituted alkyl, substimted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH* NH-alkyl, N-dialkyl,
- W is C-R" orN
- T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* orN;
- O and Q 2 independently are N or C-R; wherein R is H, alkyl or acyl;
- Q 3; Q 4s Q 5 and Q 6 independently are N or CH; and tautomeric forms thereof.
- a compound of Formula (VI), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which:
- X is CH* CH 2 OH, CHF, CF* C(Y 3 )* CHCN, C(CN) 2 , CHR 4 or C(R 4 ) 2 ;
- each R 6 is independently an optionally substimted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substimted cycloalkyl, CH 2 OH,
- each R 7 is independently -OH, optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, -O-alkyl, -O- alkenyl, -O-alkynyl, -O-aralkyl, -O-cycloalkyl-, O-acyl, F, Cl, Br, I, CN, NC, SCN, OCN, NCO, NO* NH* N 3 , NH-acyl, NH-alkyl, N-dialkyl, NH-alkenyl, NH-alkynyl, NH-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-alkenyl, S-alkynyl, S-aralkyl, S-acyl 5 S- cycloalkyl, CO 2 -alkyl, CONH-alkyl, CON-dialkyl, CONH-alken
- R 9 and R 10 come together to form a spiro compound selected from the group consisting of optionally substimted 3-7 membered spiro carbocyclic or heterocyclic compound having one or more N, O and/or S atoms, said heteroatoms independently taken alone or in combination with one another; and/or • each R s and R 11 is independently H, CH 3 , CH 2 OH, CH 2 F, CH 2 N 3 , (CH 2 ) m COOH,
- each m is independently 0 or 1;
- Base is selected from one of the following: wherein: each R', R", R'" and R"" is independently selected from the group consisting of H, OH, substimted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH* NH-alkyl, N-dialkyl,
- W is C-R" orN
- T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* orN;
- O and Q 2 independently are N or C-R; wherein R is H, alkyl or acyl;
- Q 3j Q 4 , Q 5 and Q 6 independently are N or CH; and tautomeric forms thereof.
- a compound of Formula (VI), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which:
- X is CH* CH 2 OH, CHF, CF* C(Y 3 )* CHCN, C(CN)* CHR 4 or C(R 4 ) 2 ;
- R 6 and R 7 come together to form a spiro compound selected from the group consisting of optionally substimted 3-7 membered spiro carbocyclic or heterocyclic compound having one or more N, O and/or S atoms, said heteroatoms independently taken alone or in combination with one another; and/or
- R 9 and R 10 come together to form a spiro compound selected from the group consisting of optionally substituted 3-7 membered spiro carbocyclic or heterocyclic compound having one or more N, O and/or S atoms, said heteroatoms independently taken alone or in combination with one another; and/or
- each R 8 and R n is independently H, CH 3 , CH 2 OH, CH 2 F, CH 2 N 3 , (CH 2 ) m COOH, (CH 2 ) m COOR 4 , (CH 2 ) m CONH* (CH 2 ) m CON(R 4 )* (CH 2 ) m CONHR 4 andN-acyl; and/or
- each m is independently 0 or 1 ; and/or • Base is selected from one of the following:
- each R', R", R'" and R"" is independently selected from the group consisting of H, OH, substituted or unsubstituted alkyl, substimted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH* NH-alkyl, N-dialkyl, NH-acyl, N-aryl, N-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-acyl, S-aryl, S- cycloalkyl, S-aralkyl, F, CL Br, I, CN, COOH, CONH* C0 2 -alkyl, CONH-alkyl,
- W is C-R" orN; T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* or N;
- Q ⁇ and Q 2 independently are N or C-R; wherein R is H, alkyl or acyl;
- Q 3; Q 4 , Q 5 and Q 6 independently are N or CH; and tautomeric forms thereof.
- a compound of Formula (VII), or its pharmaceutically acceptable salt or prodrug thereof, or a stereoisomeric, tautomeric or polymorphic form thereof as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VII) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which:
- X* is CH, CF, CY 3 or CR 4 ;
- each R 6 is independently an optionally substituted lower alkyl, optionally substituted alkenyl, optionally substimted alkynyl, optionally substimted cycloalkyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3,
- each R 7 is independently -OH, optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, -O-alkyl, -O- alkenyl, -O-alkynyl, -O-aralkyl, -O-cycloalkyl-, O-acyl, F, Cl, Br, I, CN, NC, SCN,
- each R 9 is independently hydrogen, optionally substimted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, - OH, -O-alkyl, -O-alkenyl, -O-alkynyl, -O-aralkyl, -O-cycloalkyl-, O-acyl, F, Cl, Br, I,
- CN NC, SCN, OCN, NCO, NO* NH* N 3 , NH-acyl, NH-alkyl, N-dialkyl, NH-alkenyl, NH-alkynyl, NH-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-alkenyl, S-alkynyl, S-aralkyl, S-acyl, S-cycloalkyl, CO 2 -alkyl, CONH-alkyl, CON-dialkyl, CONH-alkenyl, CONH- alkynyl, CONH-aralkyl, CONH-cycloalkyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 ) 2 , CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3, CF 2 CF 3 , CH 2 CO 2 R 4 ,
- each R 10 is independently hydrogen, an optionally substituted lower alkyl, optionally substituted alkenyl, optionally substimted alkynyl, optionally substimted cycloalkyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3, CF 2 CF 3 , CH 2 C0 2 R 4 , (CH 2 ) m COOH, (CH 2 )
- each m is independently 0 or 1 ;
- Base is selected from one of the following:
- each R', R", R'" and R"" is independently selected from the group consisting of H, OH, substimted or unsubstituted alkyl, substimted or unsubstituted alkenyl, substimted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH* NH-alkyl, N-dialkyl,
- W is C-R" orN
- T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* orN;
- Qi and Q 2 independently are N or C-R; wherein R is H, alkyl or acyl;
- Q 3; Q 4 , Q 5 and Q 6 independently are N or CH; and tautomeric forms thereof.
- a compound of Formula (VII), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof as well as a method for the freatment of a host infected with a
- Flaviviridae comprising administering an effective freatment amount of compound of Formula (Nil) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which:
- X* is CH, CF, CY 3 or CR 4 ;
- R 6 and R 7 come together to form a spiro compound selected from the group consisting of optionally substimted 3-7 membered spiro carbocyclic or heterocyclic compound having one or more ⁇ , O and/or S atoms, said heteroatoms independently taken alone or in combination with one another; and/or
- each R 9 is independently hydrogen, optionally substituted lower alkyl, optionally substimted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, - OH, -O-alkyl, -O-alkenyl, -O-alkynyl, -O-aralkyl, -O-cycloalkyl-, O-acyl, F, Cl, Br, I,
- each R 10 is independently hydrogen, an optionally substituted lower alkyl, optionally substimted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, CH 2 OH, CH 2 NH 2 , CH 2 NHCH 3 , CH 2 N(CH 3 ) 2 , CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3 , CF 2 CF 3 , CH 2 C0 2 R 4 , (CH 2 ) m COOH,
- each m is independently 0 or 1;
- Base is selected from one of the following: wherein: each R', R", R'" and R"" is independently selected from the group consisting of H, OH, substituted or unsubstituted alkyl, substimted or unsubstituted alkenyl, substimted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH* NH-alkyl, N-dialkyl,
- W is C-R" orN
- T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* orN;
- Qi and Q 2 independently are N or C-R;
- R is H, alkyl or acyl
- Q 3; Q 4 , Q 5 and Q 6 independently are N or CH; and tautomeric forms thereof.
- a compound of Formula (VII), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which:
- X* is CH, CF, CY 3 or CR 4 ;
- each R 6 is independently an optionally substituted lower alkyl, optionally substimted alkenyl, optionally substimted alkynyl, optionally substimted cycloalkyl, CH 2 OH,
- each R 7 is independently -OH, optionally substituted lower alkyl, optionally substimted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, -O-alkyl, -O- alkenyl, -O-alkynyl, -O-aralkyl, -O-cycloalkyl-, O-acyl, F, Cl, Br, I, CN, NC, SCN, OCN, NCO, NO* NH* N 3 , NH-acyl, NH-alkyl, N-dialkyl, NH-alkenyl, NH-alkynyl, NH-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-alkenyl, S-alkynyl, S-aralkyl, S-acyl, S- cycloalkyl, CO 2 -alkyl, CONH-alkyl, CON-dialkyl, CONH-
- R 9 and R 10 come together to form a spiro compound selected from the group consisting of optionally substituted 3-7 membered spiro carbocyclic or heterocyclic compound having one or more N, O and/or S atoms, said heteroatoms independently taken alone or in combination with one another; and/or • each R 8 and R 11 is independently H, CH 3 , CH 2 OH, CH 2 F, CH 2 N 3 , (CH 2 ) m COOH,
- each m is independently 0 or 1;
- Base is selected from one of the following: wherein: each R', R", R'" and R"" is independently selected from the group consisting of H, OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substimted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH* NH-alkyl, N-dialkyl, NH-acyl, N-aryl, N-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-acyl, S-aryl, S- cycloalkyl, S-aralkyl, F, Cl, Br, I, CN, COOH, CONH* CO 2 -alkyl, CONH-alkyl
- T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* orN;
- Qi and Q 2 independently are N or C-R;
- R is H, alkyl or acyl
- Q 3; Q 4 , Q 5 and Q 6 independently are N or CH; and tautomeric forms thereof.
- a compound of Formula (VII), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VII) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which:
- X* is CH, CF, CY 3 or CR 4 ;
- R 6 and R 7 come together to form a spiro compound selected from the group consisting of optionally substimted 3-7 membered spiro carbocyclic or heterocyclic compound having one or more N, O and/or S atoms, said heteroatoms independently taken alone or in combination with one another; and/or
- R 9 and R 10 come together to form a spiro compound selected from the group consisting of optionally substimted 3-7 membered spiro carbocyclic or heterocyclic compound having one or more N, O and/or S atoms, said heteroatoms independently taken alone or in combination with one another; and/or
- each R 8 and R u is independently H, CH 3 , CH 2 OH, CH 2 F, CH 2 N 3 , (CH 2 ) m COOH, (CH 2 ) m COOR 4 , (CH 2 ) m CONH* (CH 2 ) m CON(R 4 )* (CH 2 ) m CONHR 4 and N-acyl; and/or
- each m is independently 0 or 1; and/or • Base is selected from one of the following:
- each R', R", R'" and R"" is independently selected from the group consisting of H, OH, substimted or unsubstituted alkyl, substimted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH* NH-alkyl, N-dialkyl, NH-acyl, N-aryl, N-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-acyl, S-aryl, S- cycloalkyl, S-aralkyl, F, Cl, Br, I, CN, COOH, CONH* CO 2 -alkyl, CONH-alkyl,
- W is C-R" or N; T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* or N;
- Qi and Q 2 independently are N or C-R;
- R is H, alkyl or acyl
- Q 3; Q 4 , Q 5 and Q 6 independently are N or CH; and tautomeric forms thereof.
- R 1 is independently H or phosphate (including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug); acyl (including lower acyl); alkyl (including lower alkyl); sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl and benzyl, wherein the phenyl group is optionally substimted with one or more substituents as described in the
- R 8 and R 10 are independently H, alkyl (including lower alkyl), chlorine, bromine, or iodine; (5) X is O, S, S0 2 or CH 2 ; (6) W 4 is CX 3 ; and (7) X 3 is CH 3 , CF 3 or CH 2 CH 3 .
- R 1 is independently H or phosphate (including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug); acyl (including lower acyl); alkyl (including lower alkyl); sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl and benzyl, wherein the phenyl group is optionally substimted with one or more substituents as described
- R 1 is independently H or phosphate (including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug); acyl (including lower acyl); alkyl (including lower alkyl); sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl and benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of
- R 1 is independently H or phosphate (including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug); acyl (including lower acyl); alkyl (including lower alkyl); sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl and benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of
- R 1 is independently H or phosphate (including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug); acyl (including lower acyl); alkyl (including lower alkyl); sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl and benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl
- R 1 is independently H or phosphate (including monophosphate, diphosphate, friphosphate, or a stabilized phosphate prodrug); acyl (including lower acyl); alkyl (including lower alkyl); sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl and benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl
- the compound of Formula (VI), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof and the method for the freatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof, is provided, in which: (1) R 1 is independently H or phosphate (including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug); acyl
- R 1 is independently H or phosphate
- R 6 is alkyl
- R 7 and R 9 are independently OR 2 , alkyl (including lower alkyl), alkenyl, alkynyl, Br-vinyl, O-alkenyl, chlorine, bromine, iodine, NO* amino, loweralkylamino or di(loweralkyl)-amino; (4) R 8 and R 10 are independently
- R 1 is independently H or phosphate (including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug); acyl (including lower acyl); alkyl (including lower alkyl); sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl and benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of ary
- the compound of Formula (VI), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof and the method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which: (1) R 1 is independently H or phosphate (including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug); acyl
- R 1 is independently H or phosphate
- R 6 is alkyl (including lower alkyl), alkenyl, alkynyl, Br-vinyl, hydroxy, O-alkyl, O-alkenyl, chloro, bromo, fluoro, iodo, NO* amino, loweralkylamino or di(loweralkyl)amino
- R 7 and R 9 are independently OR 2
- R 1 is independently H or phosphate (including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug); acyl (including lower acyl); alkyl (including lower alkyl); sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl and benzyl, wherein the phenyl group is optionally substimted with one or more substituents
- R 6 is alkyl (including lower alkyl), alkenyl, alkynyl, Br-vinyl, hydroxy, O-alkyl, O-alkenyl, chloro, bromo, fluoro, iodo, NO* amino, loweralkylamino or di(loweralkyl)amino; (3) R 7 and R 9 are independently OR 2 , alkyl (including lower alkyl), alkenyl, alkynyl, Br-vinyl, O- alkenyl, chlorine, bromine, iodine, NO* amino, loweralkylamino, or di(loweralkyl)amino; (4) R 8 and R 10 are hydrogen; (5) X is O; (6) W 4 is CX 3 ; and (7) X 3 is CH 3 , CF 3 or CH 2 CH 3 .
- the compound of Formula (VI), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof and the method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which: (1) R 1 is independently H or phosphate; (2) R 6 is alkyl (including lower alkyl), alkenyl, alkynyl, Br-vinyl, hydroxy, O-alkyl, O-alkenyl, chloro, bromo, fluoro, iodo, NO* amino, loweralkylamino or di(loweralkyl)amino; (3) R 7 and R 9 are independently OR 2 ; (4) R 8 and R 10 are hydrogen; (5) X is O
- the compound of Formula (VI), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof and the method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which: (1) R 1 is independently H or phosphate; (2) R 6 is alkyl; (3) R 7 and R 9 are independently OR 2 ; (4) R 8 and R 10 are hydrogen; (5) X is O, S, SO* or CH 2 ; (6) W 4 is CX 3 ; and (7) X 3 is CH 3 , CF 3 or CH 2 CH 3 .
- the compound of Formula (VI), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof and the method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which: (1) R 1 is independently H or phosphate; (2) R 6 is alkyl; (3) R 7 and R 9 are independently OR 2 ; (4) R 8 and R 10 are independently H, alkyl (including lower alkyl), chlorine, bromine, or iodine; (5) X is O; (6) W 4 is CX 3 ; and (7) X 3 is CH 3 , CF 3 or CH 2 CH 3 .
- the compound of Formula (VI), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof and the method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof, is provided, in which: (1) R 1 is independently H or phosphate; (2) R 6 is alkyl;
- R 7 and R 9 are independently OR 2 , alkyl (including lower alkyl), alkenyl, alkynyl, Br- vinyl, O-alkenyl, chlorine, bromine, iodine, NO* amino, loweralkylamino or di(loweralkyl)amino; (4) R 8 and R 10 are hydrogen; (5) X is O; (6) W 4 is CX 3 ; and (7) X 3 is CH 3 , CF 3 or CH 2 CH 3 .
- the compound of Formula (VI), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof and the method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (VI) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof, is provided, in which:
- Base 8-methyladenine; (2) R 1 is hydrogen; (3) R 6 is methyl; (4) R 7 and R 9 are hydroxyl; (5) R 8 and R 10 are hydrogen; and (6) X is O;
- Base 8-methylguanine; (2) R 1 is hydrogen; (3) R 6 is methyl; (4) R 7 and R 9 are hydroxyl; (5) R 8 and R 10 are hydrogen; and (6) X is O; (1) Base is 6-methylcytosine; (2) R 1 is hydrogen; (3) R 6 is methyl; (4) R 7 and R 9 are hydroxyl; (5) R 8 and R 10 are hydrogen; and (6) X is O;
- Base 6-methylthymidine; (2) R 1 is hydrogen; (3) R 6 is methyl; (4) R 7 and R 9 are hydroxyl; (5) R 8 and R 10 are hydrogen; and (6) X is O; 2004/002999
- Base 6-methyluracil; (2) R 1 is hydrogen; (3) R 6 is methyl; (4) R 7 and R 9 are hydroxyl; (5) R and R ,10 are hydrogen; and (6) X is O;
- Base 8-methyladenine; (2) R 1 is phosphate; (3) R 6 is methyl; (4) R 7 and R 9 are hydroxyl; (5) R 8 and R 10 are hydrogen; and (6) X is O;
- Base 8-methyladenine; (2) R 1 is hydrogen; (3) R 6 is ethyl; (4) R 7 and R 9 are hydroxyl; (5) R 8 and R 10 are hydrogen; and (6) X is O;
- Base 8-methyladenine; (2) R 1 is hydrogen; (3) R 6 is propyl; (4) R 7 and R 9 are hydroxyl; (5) R 8 and R 10 are hydrogen; and (6) X is O;
- Base 8-methyladenine; (2) R 1 is hydrogen; (3) R 6 is butyl; (4) R 7 and R 9 are hydroxyl; (5) R 8 and R 10 are hydrogen; and (6) X is O;
- Base 8-methyladenine; (2) R 1 is hydrogen; (3) R 6 is methyl; (4) R 7 is hydrogen and R 9 is hydroxyl; (5) R 8 and R 10 are hydrogen; and (6) X is O;
- Base 8-methyladenine; (2) R 1 is hydrogen; (3) R 6 is methyl; (4) R 7 and R 9 are hydroxyl; (5) R 8 and R 10 are hydrogen; and (6) X is S;
- Base 8-methyladenine; (2) R 1 is hydrogen; (3) R 6 is methyl; (4) R 7 and R 9 are hydroxyl; (5) R 8 and R 10 are hydrogen; and (6) X is SO*
- Base 8-methyladenine; (2) R 1 is hydrogen; (3) R 6 is methyl; (4) R 7 and R 9 are hydroxyl; (5) R 8 and R 10 are hydrogen; and (6) X is CH*
- a compound of Formula (VIII), (IX) or (X) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric, or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective freatment amount of compound of Formula (VIII), (IX), or (X):
- each R 12 is independently a substimted alkyl (including lower alkyl), CH 2 CN, CH 2 N 3 , CH 2 NH 2 , CH 2 NHCH 3 , CH 2 N(CH 3 ) 2 , CH 2 OH, halogenated alkyl (including halogenated lower alkyl), CF 3 , C(Y 3 ) 3 , 2-Br-ethyl, CH 2 F, CH 2 C1, CH 2 CF 3 , CF 2 CF 3 , C(Y 3 ) 2 C(Y 3 ) 3 , substimted alkenyl, halo
- R 12 and R 13 can come together to form a spiro compound selected from the group consisting of optionally substituted carbocycle (preferably a 3-7 membered carbocyclic ring) or optionally substituted heterocycle (preferably a 3-7 membered heterocyclic ring having one or more O, S and/or N); and each m is independently 0, 1 or 2.
- a compound of Formula (XI) or (XII) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric, or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective freatment amount of compound of Formula (XI) or (XII):
- R 8 in Formula (XI) is -OH or -NH 2 only when X is carbon; and wherein; each R 8 and R ⁇ is independently hydrogen, an optionally substimted alkyl (including lower alkyl), CH 3 , CH 2 CN, CH 2 N 3 , CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 OH, halogenated alkyl (including halogenated lower alkyl), CF 3 , C(Y 3 ) 3 , 2-Br-ethyl, CH 2 F, CH 2 C1, CH 2 CF 3 , CF 2 CF 3 , C(Y 3 ) 2 C(Y 3 ) 3 , optionally substimted alkenyl, haloalkenyl, Br-vinyl, optionally substituted alkynyl, haloalkynyl, -CH 2 C(0)OH, -CH 2 C(0)OR 4 ,
- compounds of the Formula (XIII) or (XIV) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective freatment amount of compound of Formula (XIII) or (XIV):
- R 3 is selected from the group consisting of H; mono-, di-, and tri-phosphate or a stabilized phosphate prodrug; acyl; a sulfonate ester; optionally substimted alkyl sulfonyl; optionally substituted arylsulfonyl; a lipid; an amino acid; a carbohydrate; a peptide; cholesterol; and a pharmaceutically acceptable leaving group which when administered in vivo is capable of providing a compound wherein R 3 is independently H, or mono-, di- or triphosphate; X" is selected from the group consisting of one or more O, S, SO, SO* N, NH, NR and CH 2 wherein any of the aforementioned may be optionally substimted and may be variably positioned so as to form a 3-7 membered ring
- R is H, alkyl or acyl
- B indicates a spiro compound selected from the group consisting of optionally substituted carbocycle (preferably a 3-7 membered carbocyclic ring) or optionally substimted heterocycle (preferably a 3-7 membered heterocyclic ring having one or more O, S and/or
- Base is selected from the group consisting of:
- each R', R", R'" and R" are independently selected from the group consisting of
- H OH, substimted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH* NH-alkyl, N-dialkyl,
- W is C-R" orN; T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* or N;
- Qi and Q 2 independently are N or C-R;
- R is H, alkyl or acyl
- Q 3 ⁇ Q , Q 5 and Q 6 independently are N or CH; and tautomeric forms thereof.
- a compound of Formula (XV), (XVI) or (XVII) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (XV), (XVI), or (XVII):
- G and E independently are selected from the group consisting of H, CH 3 , CH 2 OH 5 CH F, CH 2 N 3 , CH 2 CN, (CH 2 ) m COOH, (CH 2 ) m COOR, (CH 2 ) m CONH* (CH 2 ) m CONR* (CH 2 ) m CONHR and N-acyl; R is H, alkyl or acyl; m is O or 1; and R 3 and Base are as defined for Formula (XIII).
- At most one of G and E can further be hydrogen.
- a compound of Formula (XVIII) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof is provided, as well as a method for the freatment of a host infected with a
- Flaviviridae comprising administering an effective treatment amount of compound of Formula (XVIII):
- R 3 and Base are as defined for Formula (XIII).
- a compound of Formula (XIX), (XX), (XXI) (XXII) or (XX ⁇ i) or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymo ⁇ hic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (XIX), (XXI), (XXII), or (XXIII):
- A is selected from the group consisting of optionally substituted lower alkyl, cycloalkyl, alkenyl, alkynyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1 5 CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3 , CF 2 CF 3 , CH 2 CO 2 R, (CH 2 ) m COOH, (CH 2 ) m COOR, (CH 2 ) m CO- NH* (CH 2 ) m CONR* and (CH 2 ) m CONHR;
- Y is selected from the group consisting of H, optionally substimted lower alkyl, cycloalkyl, alkenyl, alkynyl, CH 2 OH, CH 2 NH* CH 2 NHCH 3 , CH 2 N(CH 3 )* CH 2 F, CH 2 C1, CH 2 N 3 , CH 2 CN, CH 2 CF 3 , CF 3, CF 2 CF 3 , CH 2 CO 2 R, (CH 2 ) m COOH, (CH 2 ) m COOR, (CH 2 ) m CONH* (CH 2 ) m CONR 2 , and (CH 2 ) m CONHR;
- R is H, alkyl or acyl;
- X is selected from the group consisting of -OH, optionally substituted alkyl, cycloalkyl, alkenyl, alkynyl, -O-alkyl, -O-alkenyl, -O-alkynyl, -O-aryl, -O-aralkyl, -O-cycloalkyl-, O-acyl, F, Cl, Br, I, CN, NC, SCN, OCN, NCO, NO* NH* N 3 , NH-acyl, NH-alkyl, N- dialkyl, NH-alkenyl, NH-alkynyl, NH-aryl, NH-aralkyl, NH-cycloalkyl, SH, S-alkyl, S- alkenyl, S-alkynyl, S-aryl, S-aralkyl, S-acyl, S-cycloalkyl, C0 2 -alkyl, CONH-alkyl,
- Base is a non-natural base selected from the group of:
- each R', R", R'" and R"" is independently selected from the group consisting of H, OH, substimted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, -O-alkyl, O-alkenyl, O- alkynyl, O-aryl, O-aralkyl, -O-acyl, O-cycloalkyl, NH* NH-alkyl, N-dialkyl, NH-acyl, N-aryl, N-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-acyl, S-aryl, S- cycloalkyl, S-aralkyl, F, Cl, Br, I, CN, COOH, CONH* CO 2 -alkyl, CONH-alkyl, CON-dialkyl, OH,
- T and V independently are CH or N;
- Q is CH, -CCl, -CBr, -CF, -CI, -CCN, -C-COOH, -C-CONH* or N;
- Qi and Q 2 independently are N or C-R"";
- Q 3 , Q4, Q5 and Q 6 independently are N or CH; with the proviso that in bases (g) and (i), R', R"" are not H, OH, or NH* and Q,
- T, V, Q* Q 5 and Q 6 are not N.
- a compound of Formula (IX), or a pharmaceutically acceptable salt or prodrug, or a stereoisomeric, tautomeric or polymorphic form thereof is provided, as well as a method for the treatment of a host infected with a Flaviviridae comprising administering an effective treatment amount of compound of Formula (IX):
- R 1 , R 2 and R 3 are independently H; phosphate; straight chained, branched or cyclic alkyl; acyl; CO-alkyl; CO-aryl; CO-alkoxyalkyl; CO-aryloxyalkyl; CO-substituted aryl; sulfonate ester; benzyl, wherein the phenyl group is optionally substituted with one or more substituents; alkylsulfonyl; arylsulfonyl; aralkylsulfonyl; a lipid; an amino acid; a carbohydrate; a peptide; cholesterol; or a pharmaceutically acceptable leaving group which when administered in vivo is capable of providing a compound wherein R 1 , R 2 and/or R 3 is independently H or phosphate;
- X is O, S, SO 2 or CH 2 ;
- Base* is a purine or pyrimidine base
- R 12 is C(Y 3 ) 3 ;
- Y 3 is independently H, F, Cl, Br or I;
- R 13 is fluoro
- X is O
- Y 3 is H
- R 1 , R 2 and R 3 are also H.
- nucleosides of the present invention have several chiral centers and may exist in and be isolated in optically active and racemic forms. Some compounds may exhibit polymo ⁇ hism. It is to be understood that the present invention encompasses any racemic, optically-active, diastereomeric, polymorphic, or stereoisomeric form, or mixtures thereof, of a compound of the invention, which possess the useful properties described herein. It being well known in the art how to prepare optically active forms (for example, by resolution of the racemic form by recrystallization techniques, by synthesis from optically-active starting materials, by chiral synthesis, or by chromatographic separation using a chiral stationary phase).
- the 1' and 4' carbons of the nucleoside are chiral, their nonhydrogen substituents (the base and the CHOR groups, respectively) can be either cis (on the same side) or trans (on opposite sides) with respect to the sugar ring system.
- the four optical isomers therefore are represented by the following configurations (when orienting the sugar moiety in a horizontal plane such that the oxygen atom is in the back): cis (with both groups “up”, which corresponds to the configuration of naturally occuning ⁇ - D nucleosides), cis (with both groups “down”, which is a nonnaturally occuning ⁇ -L configuration), trans (with the C2' substituent "up” and the C4' substituent "down”), and trans (with the C2' substituent "down” and the C4' substituent "up”).
- the "D-nucleosides” are cis nucleosides in a natural configuration and the "L-nucleosides” are cis nucleosides in the nonnaturally occuning configuration.
- most amino acids are chiral (designated as L or D, wherein the L enantiomer is the naturally occuning configuration) and can exist as separate enantiomers.
- methods to obtain optically active materials include at least the following. i) physical separation of crystals - a technique whereby macroscopic crystals of the individual enantiomers are manually separated.
- This technique can be used if crystals of the separate enantiomers exist, i.e., the material is a conglomerate, and the crystals are visually distinct; ii) simultaneous crystallization - a technique whereby the individual enantiomers are separately crystallized from a solution of the racemate, possible only if the latter is a conglomerate in the solid state; iii) enzymatic resolutions - a technique whereby partial or complete separation of a racemate by virtue of differing rates of reaction for the enantiomers with an enzyme; iv) enzymatic asymmetric synthesis - a synthetic technique whereby at least one step of the synthesis uses an enzymatic reaction to obtain an enantiomerically pure or enriched synthetic precursor of the desired enantiomer; v) chemical asymmetric synthesis - a synthetic technique whereby the desired enantiomer is synthesized from an achiral precursor under conditions that produce asymmetry (i.e., chirality) in the
- the resulting diastereomers are then separated by chromatography or crystallization by virtue of their now more distinct structural differences and the chiral auxiliary later removed to obtain the desired enantiomer; vii) first- and second-order asymmetric transformations - a technique whereby diastereomers from the racemate equilibrate to yield a preponderance in solution of the diastereomer from the desired enantiomer or where preferential crystallization of the diastereomer from the desired enantiomer perturbs the equilibrium such that eventually in principle all the material is converted to the crystalline diastereomer from the desired enantiomer.
- kinetic resolutions this technique refers to the achievement of partial or complete resolution of a racemate (or of a further resolution of a partially resolved compound) by virtue of unequal reaction rates of the enantiomers with a chiral, non-racemic reagent or catalyst under kinetic conditions; ix) enantiospecific synthesis from non-racemic precursors - a synthetic technique whereby the desired enantiomer is obtained from non-chiral starting materials and where the stereochemical integrity is not or is only minimally compromised over the course of the synthesis; x) chiral liquid chromatography - a technique whereby the enantiomers of a racemate are separated in a liquid mobile phase by virtue of their differing interactions with a stationary phase.
- the stationary phase can be made of chiral material or the mobile phase can contain an additional chiral material to provoke the differing interactions; xi) chiral gas chromatography - a technique whereby the racemate is volatilized and enantiomers are separated by virtue of their differing interactions in the gaseous mobile phase with a column containing a fixed non-racemic chiral adsorbent phase; xii) extraction with chiral solvents - a technique whereby the enantiomers are separated by virtue of preferential dissolution of one enantiomer into a particular chiral solvent; xiii) transport across chiral membranes - a technique whereby a racemate is placed in contact with a thin membrane barrier.
- the barrier typically separates two miscible fluids, one containing the racemate, and a driving force such as concentration or pressure differential causes preferential transport across the membrane banier. Separation occurs as a result of the non-racemic chiral nature of the membrane which allows only one enantiomer of the racemate to pass through.
- alkyl refers to a saturated straight, branched, or cyclic, primary, secondary, or tertiary hydrocarbon of typically C ⁇ to
- Cio and specifically includes methyl, CF 3 , CC1 3 , CFC1* CF 2 C1, ethyl, CH 2 CF 3 , CF 2 CF 3 , propyl, isopropyl, cyclopropyl, butyl, isobutyl, secbutyl, t-butyl, pentyl, cyclopentyl, isopentyl, neopentyl, hexyl, isohexyl, cyclohexyl, cyclohexylmethyl, 3-methylpentyl, 2,2- dimethylbutyl, and 2,3-dimethylbutyl.
- the term includes both substimted and unsubstituted alkyl groups, and particularly includes halogenated alkyl groups, and even more particularly fluorinated alkyl groups.
- moieties with which the alkyl group can be substimted are selected from the group consisting of halogen (fluoro, chloro, bromo or iodo), hydroxyl, amino, alkylamino, arylamino, alkoxy, aryloxy, nifro, cyano, sulfonic acid, sulfate, phosphonic acid, phosphate, or phosphonate, either unprotected, or protected as necessary, as known to those skilled in the art, for example, as taught in Greene, et al,
- lower alkyl refers to a Ci to C 4 saturated straight, branched, or if appropriate, a cyclic (for example, cyclopropyl) alkyl group, including both substituted and unsubstituted moieties.
- alkylamino or "arylamino” refers to an amino group that has one or two alkyl or aryl substituents, respectively. Unless otherwise specifically stated in this application, when alkyl is a suitable moiety, lower alkyl is prefened. Similarly, when alkyl or lower alkyl is a suitable moiety, unsubstituted alkyl or lower alkyl is prefened.
- protected refers to a group that is added to an oxygen, nitrogen, or phosphorus atom to prevent its further reaction or for other pu ⁇ oses.
- oxygen and nitrogen protecting groups are known to those skilled in the art of organic synthesis.
- aryl refers to phenyl, biphenyl, or naphthyl, and preferably phenyl.
- the term includes both substituted and unsubstimted moieties.
- the aryl group can be substimted with any described moiety, including, but not limited to,one or more moieties selected from the group consisting of halogen (fluoro, chloro, bromo or iodo), hydroxyl, amino, alkylamino, arylamino, alkoxy, aryloxy, nitro, cyano, sulfonic acid, sulfate, phosphonic acid, phosphate, or phosphonate, either unprotected, or protected as necessary, as known to those skilled in the art, for example, as taught in Greene, et al, Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991.
- alkaryl or “alkylaryl” refers to an alkyl group with an aryl substituent.
- aralkyl or arylalkyl refers to an aryl group with an alkyl substituent.
- halo includes chloro, bromo, iodo, and fluoro.
- purine or pyrimidine base includes, but is not limited to, adenine, N 6 - alkylpurines, N 6 -acylpurines (wherein acyl is C(O)(alkyl, aryl, alkylaryl, or arylalkyl), N 6 - benzylpurine, N 6 -halopurine, N 6 -vinylpurine, N 6 -acetylenic purine, N 6 -acyl purine, N 6 -hydroxyalkyl purine, N 6 -alkylaminopurine, N 6 -thioalkyl purine, N 2 -alkylpurines, N 2 - alkyl-6-thiopurines, thymine, cytosine, 5-fluorocytosine, 5-methylcytosine, 6- azapyrimidine, including 6-azacytosine,
- Purine bases include, but are not limited to, guanine, adenine, hypoxanthine, 2,6-diaminopurine, and 6-chloropurine. Functional oxygen and nitrogen groups on the base can be protected as necessary or desired.
- Suitable protecting groups are well known to those skilled in the art, and include frimethylsilyl, dimethylhexylsilyl, t- butyldimethylsilyl, and t-butyldiphenylsilyl, frityl, alkyl groups, and acyl groups such as acetyl and propionyl, methanesulfonyl, and p-toluenesulfonyl.
- acyl refers to a group of the formula C(O)R', wherein R' is an straight, branched, or cyclic alkyl (including lower alkyl), amino acid, aryl including phenyl, alkaryl, aralkyl including benzyl, alkoxyalkyl including methoxymethyl, aryloxyalkyl such as phenoxymethyl; or substimted alkyl (including lower alkyl), aryl including phenyl optionally substituted with chloro, bromo, fluoro, iodo, to C 4 alkyl or d to C 4 alkoxy, sulfonate esters such as alkyl or aralkyl sulphonyl including methanesulfonyl, the mono, di or triphosphate ester, trityl or monomethoxy-trityl, substituted benzyl, alkaryl, aralkyl including benzyl,
- Aryl groups in the esters optimally comprise a phenyl group.
- acyl groups include acetyl, trifluoroacetyl, methylacetyl, cyclopropylacetyl, cyclopropyl carboxy, propionyl, butyryl, hexanoyl, heptanoyl, octanoyl, neo-heptanoyl, phenylacetyl, 2-acetoxy-2-phenylacetyl, diphenylacetyl, ⁇ -methoxy- ⁇ - trifluoromethyl-phenylacetyl, bromoacetyl, 2-nitro-benzeneacetyl, 4-chloro-benzeneacetyl, 2-chloro-2,2-diphenylacetyl, 2-chloro-2-phenylacetyl, frimethylacetyl, chlorodifluoroacetyl, perfluoroacetyl, fluoro
- acyl when the term acyl is used, it is meant to be a specific and independent disclosure of acetyl, trifluoroacetyl, methylacetyl, cyclopropylacetyl, propionyl, butyryl, hexanoyl, heptanoyl, octanoyl, neo-heptanoyl, phenylacetyl, diphenylacetyl, ⁇ -frifluoromethyl-phenylacetyl, bromoacetyl, 4-chloro- benzeneacetyl, 2-chloro-2,2-diphenylacetyl, 2-chloro-2-phenylacetyl, frimethylacetyl, chlorodifluoroacetyl, perfluoroacetyl, fluoroacetyl, bromodifluoroacetyl, 2-thiopheneacetyl, tert-butylacetyl,
- amino acid includes naturally occuning and synthetic , ⁇ ⁇ or ⁇ amino acids, and includes but is not limited to, amino acids found in proteins, i.e. glycine, alanine, valine, leucine, isoleucine, methionine, phenylalanine, tryptophan, proline, serine, threonine, cysteine, tyrosine, asparagine, glutamine, aspartate, glutamate, lysine, arginine and histidine.
- the amino acid is in the L-configuration.
- the amino acid can be a derivative of alanyl, valinyl, leucinyl, isoleuccinyl, prolinyl, phenylalaninyl, tryptophanyl, methioninyl, glycinyl, serinyl, threoninyl, cysteinyl, tyrosinyl, asparaginyl, glutaminyl, aspartoyl, glutaroyl, lysinyl, argininyl, histidinyl, ⁇ - alanyl, ⁇ -valinyl, ⁇ -leucinyl, ⁇ -isoleuccinyl, ⁇ -prolinyl, ⁇ -phenylalaninyl, ⁇ -tryptophanyl, ⁇ -methioninyl, ⁇ -glycinyl, ⁇ -serinyl, ⁇ -threoninyl, ⁇ -cysteinyl
- Tables 1-24 set out examples of species within the present invention.
- amino acid it is considered to be a specific and independent disclosure of each of the esters of ⁇ , ⁇ ⁇ or ⁇ glycine, alanine, valine, leucine, isoleucine, methionine, phenylalanine, tryptophan, proline, serine, threonine, cysteine, tyrosine, asparagine, glutamine, aspartate, glutamate, lysine, arginine and histidine in the D and L-configurations.
- nucleoside composition that includes at least 85 or 90% by weight, preferably
- the compounds are substantially free of enantiomers.
- isolated refers to a nucleoside composition that includes at least 85%, 90%, 95%, 98%, 99%, or 100% by weight, of the nucleoside, the remainder comprising other chemical species or enantiomers.
- the term "host”, as used herein, refers to an unicellular or multicellular organism in which the virus can replicate, including cell lines and animals, and preferably a human. Alternatively, the host can be carrying a part of the Flaviviridae viral genome, whose replication or function can be altered by the compounds of the present invention.
- the term host specifically refers to infected cells, cells transfected with all or part of the Flaviviridae genome and animals, in particular, primates (including chimpanzees) and humans. In most animal applications of the present invention, the host is a human patient. Veterinary applications, in certain indications, however, are clearly anticipated by the present invention (such as chimpanzees).
- pharmaceutically acceptable salt or prodrug is used throughout the specification to describe any pharmaceutically acceptable form (such as an ester, phosphate ester, salt of an ester or a related group) of a nucleoside compound which, upon administration to a patient, provides the nucleoside compound.
- Pharmaceutically acceptable salts include those derived from pharmaceutically acceptable inorganic or organic bases and acids. Suitable salts include those derived from alkali metals such as potassium and sodium, alkaline earth metals such as calcium and magnesium, among numerous other acids well known in the pharmaceutical art.
- Pharmaceutically acceptable prodrugs refer to a compound that is metabolized, for example hydrolyzed or oxidized, in the host to form the compound of the present invention.
- prodrugs include compounds that have biologically labile protecting groups on a functional moiety of the active compound.
- Prodrugs include compounds that can be oxidized, reduced, aminated, deaminated, hydroxylated, dehydroxylated, hydrolyzed, dehydrolyzed, alkylated, dealkylated, acylated, deacylated, phosphorylated, dephosphorylated to produce the active compound.
- the compounds of this invention possess antiviral activity against a Flaviviridae, or are metabolized to a compound that exhibits such activity.
- the active compound can be administered as any salt or prodrug that upon administration to the recipient is capable of providing directly or indirectly the parent compound, or that exhibits activity itself.
- Nonlimiting examples are the pharmaceutically acceptable salts (alternatively refened to as "physiologically acceptable salts"), and a compound, which has been alkylated, acylated, or otherwise modified at the 5 '-position, or on the purine or pyrimidine base (a type of "pharmaceutically acceptable prodrug").
- physiologically acceptable salts alternatively refened to as "physiologically acceptable salts”
- a compound, which has been alkylated, acylated, or otherwise modified at the 5 '-position, or on the purine or pyrimidine base a type of "pharmaceutically acceptable prodrug”
- the modifications can affect the biological activity of the compound, in some cases increasing the activity over the parent compound. This can easily be assessed by preparing the salt or prodrug and testing its antiviral activity according to the methods described herein, or other methods
- pharmaceutically acceptable salts are organic acid addition salts formed by addition of acids, which form a physiological acceptable anion, for example, tosylate, methanesulfonate, acetate, citrate, malonate, tartarate, succinate, benzoate, ascorate, ⁇ -ketoglutarate, ⁇ -glycerophosphate, formate, fumarate, propionate, glycolate, lactate, pyruvate, oxalate, maleate, and salicylate.
- acids which form a physiological acceptable anion
- Suitable inorganic salts may also be formed, including, sulfate, nitrate, bicarbonate, carbonate salts, hydrobromate and phosphoric acid.
- the salt is a mono- or di- hydrochloride salt.
- salts may be obtained using standard procedures well known in the art, for example by reacting a sufficiently basic compound such as an amine with a suitable acid affording a physiologically acceptable anion.
- Alkali metal (for example, sodium, potassium or lithium) or alkaline earth metal (for example calcium) salts of carboxylic acids can also be made.
- the salt is a hydrochloride salt of the compound.
- the pharmaceutically acceptable salt is a dihydrochloride salt.
- nucleosides described herein can be administered as a nucleotide prodrug to increase the activity, bioavailability, stability or otherwise alter the properties of the nucleoside.
- a number of nucleotide prodrug ligands are known.
- alkylation, acylation or other lipophilic modification of the mono-, di- or triphosphate of the nucleoside reduces polarity and allows passage into cells.
- substituent groups that can replace one or more hydrogens on the phosphate moiety are alkyl, aryl, steroids, carbohydrates, including sugars, 1,2-diacylglycerol and alcohols. Many are described in R. Jones and N. Bischoferger, Antiviral Research, 1995, 27:1-17. Any of these can be used in combination with the disclosed nucleosides to achieve a desired effect.
- the nucleoside is delivered as a phosphonate or a
- the active nucleoside can also be provided as a 2', 3' and/or 5'-phosphoether lipid or a 2', 3' and/or 5'-ether lipid.
- Non-limiting examples are described include the following references, which are incorporated by reference herein: Kucera, L.S., N. Iyer, E. Leake, A. Raben, Modest E.K., D.L.W., and C. Piantadosi. 1990. "Novel membrane-interactive ether lipid analogs that inhibit infectious HJN-1 production and induce defective virus formation.” AIDS Res. Hum. Retro Viruses. 6:491-501; Piantadosi, C, J. Marasco C.J., S.L.
- Nonlimiting examples of U.S. patents that disclose suitable lipophilic substituents that can be covalently incorporated into the nucleoside, preferably at the 2', 3' and/or 5'-OH position of the nucleoside or lipophilic preparations include U.S. Patent Nos. 5,149,794 (Sep. 22, 1992, Yatvin et al); 5,194,654 (Mar. 16, 1993, Hostetler et al, 5,223,263 (June 29, 1993, Hostetler et al); 5,256,641 (Oct. 26, 1993, Yatvin et al); 5,411,947 (May 2, 1995, Hostetler et al); 5,463,092 (Oct.
- lipophilic substituents that can be attached to the nucleosides of the present invention, or lipophilic preparations, include WO 89/02733, W0 90/00555, W0 91/16920, W0 91/18914, W0 93/00910, W0 94/26273, W0 96/15132, EP 0350287, EP 93917054.4, and W0 91/19721.
- Aryl esters especially phenyl esters, are also provided. Nonlimiting examples are disclosed in DeLambert et al., J. Med. Chem. 37: 498 (1994). Phenyl esters containing a carboxylic ester ortho to the phosphate are also provided. Khamnei and Tonence, J. Med. Chem.; 39:4109-4115 (1996). In particular, benzyl esters, which generate the parent compound, in some cases using substituents at the ortho- or para-position to accelerate hydrolysis, are provided. Examples of this class of prodrugs are described by Mitchell et al., J. Chem. Soc. Perkin Trans. I 2345 (1992); Brook, et al. WO 91/19721; and Glazier et al. WO 91/19721.
- Cyclic and noncyclic phosphonate esters are also provided. Nonlimiting examples are disclosed in Hunston et al., J. Med. Chem. 27: 440-444 (1984) and Starrett et al. J. Med.
- cyclic 3',5'-phosphate esters are provided. Nonlimiting examples are disclosed in Meier et al. J. Med. Chem. 22: 811-815 (1979). Cyclic l',3'-propanyl phosphonate and phosphate esters, such as ones containing a fused aryl ring, i.e. the cyclosaligenyl ester, are also provided (Meier et al., Bioorg. Med. Chem. Lett. 7: 99-104 (1997)). Unsubstituted cyclic l',3'- ⁇ ropanyl esters of the monophosphates are also provided (Farquhar et al., J.
- Cyclic phosphoramidates are known to cleave in vivo by an oxidative mechanism. Therefore, in one embodiment of the present invention, a variety of substituted l',3' propanyl cyclic phosphoramidates are provided. Non-limiting examples are disclosed by Zon, Progress in Med. Chem. 19, 1205 (1982). Additionally, a number of 2'- and 3'- substimted proesters are provided.
- 2'-Substituents include methyl, dimethyl, bromo, trifluoromethyl, chloro, hydroxy, and methoxy; 3 '-substituents including phenyl, methyl, trifluoromethyl, ethyl, propyl, i-propyl, and cyclohexyl. A variety of l'-substituted analogs are also provided.
- Cyclic esters of phosphorus-containing compounds are also provided. Non-limiting examples are described in the following:
- V and Z are connected via an additional 3-5 atoms to form a cyclic group containing 5-7 atoms, optionally 1 heteroatom, substimted with hydroxy, acyloxy, alkoxycarbonyloxy, or aryloxycarbonyloxy attached to a carbon atom that is three atoms from both O groups attached to the phosphorus; or
- V and Z are connected via an additional 3-5 atoms to form a cyclic group, optionally containing 1 heteroatom, that is fused to an aryl group at the beta, and gamma position to the O attached to the phosphorus;
- V and W are connected via an additional 3 carbon atoms to form an optionally substituted cyclic group containing 6 carbon atoms and substituted with one substituent selected from the group consisting of hydroxy, acyloxy, alkoxycarbonyloxy, alkylthiocarbonyloxy, and aryloxycarbonyloxy, attached to one of said carbon atoms that is three atoms from an O attached to the phosphorus;
- Z and W are connected via an additional 3-5 atoms to form a cyclic group, optionally containing one heteroatom, and V must be aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
- W and W are connected via an additional 2-5 atoms to form a cyclic group, optionally containing 0-2 heteroatoms, and V must be aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
- Z is selected from the group consisting of -CHR 2 OH, -CHR 2 OC(O)R 3 , -CHR 2
- R 2 is selected from the group consisting of R 3 and -H;
- R 3 is selected from the group consisting of alkyl, aryl, alicyclic, and aralkyl; • R 12 is selected from the group consisting of -H, and lower acyl;
- M is the biologically active agent, and that is attached to the phosphorus in formula I via the 2', 3' and/or 5'-hydroxyl.
- the active compounds of the present invention can be administered in combination or alternation with another anti-flavivirus or pestivirus agent, or in particular an anti-HCV agent to treat any of the conditions described herein.
- effective dosages of two or more agents are administered together, whereas in alternation or sequential-step therapy, an effective dosage of each agent is administered serially or sequentially.
- the dosages given will depend on abso ⁇ tion, inactivation and excretion rates of the drug as well as other factors known to those of skill in the art. It is to be noted that dosage values will also vary with the severity of the condition to be alleviated.
- an anti-HCV (or anti-pestivirus or anti-flavivirus) compound that exhibits an EC 50 of 10-15 ⁇ M, or preferably less than 1-5 ⁇ M, is desirable.
- the efficacy of a drug against the viral infection can be prolonged, augmented, or restored by administering the compound in combination or alternation with a second, and perhaps third, antiviral compound that induces a different mutation from that caused by the principle drug.
- the pharmacokinetics, biodistribution or other parameter of the drug can be altered by such combination or alternation therapy.
- combination therapy is typically prefened over alternation therapy because it induces multiple simultaneous stresses on the virus.
- Any of the viral treatments described in the Background of the Invention can be used in combination or alternation with the compounds described in this specification. Nonlimiting examples include:
- Protease inhibitors examples include substrate-based NS3 protease inhibitors (Attwood et al., Antiviral peptide derivatives, PCT WO 98/22496, 1998; Attwood et al., Antiviral Chemistry and Chemotherapy 1999, 10, 259-273; Attwood et al., Preparation and use of amino acid derivatives as anti-viral agents, German Patent Pub. DE 19914474; Tung et al.
- Inhibitors of serine proteases particularly hepatitis C virus NS3 protease, PCT WO 98/17679), including alphaketoamides and hydrazinoureas, and inhibitors that terminate in an electrophile such as a boronic acid or phosphonate (Llinas-Brunet et al, Hepatitis C inhibitor peptide analogues, PCT WO 99/07734); Non-substrate-based NS3 protease inhibitors such as 2,4,6-trihydroxy- 3-nitro-benzamide derivatives (Sudo K. et al., Biochemical and Biophysical Research Communications, 1997, 238, 643-647; Sudo K. et al.
- Eglin c isolated from leech, is a potent inhibitor of several serine proteases such as S. griseus proteases A and B, ⁇ -chymotrypsin, chymase and subtilisin. Qasim M.A. et al., Biochemistry 36:1598-1607, 1997.
- U.S. patents disclosing protease inhibitors for the treatment of HCV include, for example, U.S. Patent No. 6,004,933 to Spruce et al. which discloses a class of cysteine protease inhibitors for inhibiting HCV endopeptidase 2; U.S. Patent No. 5,990,276 to Zhang et al. which discloses synthetic inhibitors of hepatitis C virus NS3 protease; U.S. Patent No. 5,538,865 to Reyes et a; WO 02/008251 to Corvas International, Inc, and WO 02/08187 and WO 02/008256 to Schering Corporation.
- HCV inhibitor tripeptides are disclosed in US Patent Nos.
- Diaryl peptides as NS3 serine protease inhibitors of HCV are disclosed in WO 02/48172 to Schering Co ⁇ oration.
- Imidazoleidinones as NS3 serine protease inhibitors of HCV are disclosed in WO 02/08198 to Schering Co ⁇ oration and WO 02/48157 to Bristol Myers Squibb.
- Vertex Pharmaceuticals and WO 02/48116 to Bristol Myers Squibb also disclose HCV protease inhibitors.
- S-ODN Antisense phosphorothioate oligodeoxynucleotides (S-ODN) complementary to sequence stretches in the 5' non-coding region (NCR) of the virus (Alt M. et al., Hepatology, 1995, 22, 707-717), or nucleotides 326-348 comprising the 3' end of the NCR and nucleotides 371-388 located in the core coding region of the HCV RNA (Alt M. et al., Archives of Virology, 1997, 142, 589-599; Galderisi U.
- Patent No. 6,034,134 to Gold et al. alkyl lipids (U.S. Pat. No. 5,922,757 to Chojkier et al.), vitamin E and other antioxidants (U.S. Pat. No. 5,922,757 to Chojkier et al.), squalene, amantadine, bile acids (U.S. Pat. No. 5,846,964 to Ozeki et al.), N-(phosphonoacetyl)-L-aspartic acid, (U.S. Pat. No. 5,830,905 to Diana et al.), benzenedicarboxamides (U.S. Pat. No.
- RNA replication inhibitors (VP50406) by ViroPharma/Wyeth, therapeutic vaccine by Intercell, therapeutic vaccine by Epimmune/Genencor, IRES inhibitor by Anadys, ANA 245 and ANA 246 by Anadys, immunotherapy (Therapore) by Avant, protease inhibitor by Corvas/SChering, helicase inhibitor by Vertex, fusion inhibitor by Trimeris, T cell therapy by CellExSys, polymerase inhibitor by Biocryst, targeted RNA chemistry by PTC Therapeutics, Dication by Immtech, Int., protease inhibitor by Agouron, protease inhibitor by Chiron/Medivir, antisense therapy by AVI BioPharma, antisense therapy by Hybridon, hemopurifier by
- Hosts including humans, infected with pestivirus, flavivirus, HCV infection, or any other condition described herein, or another organism replicating through a RNA-dependent RNA viral polymerase, or for treating any other disorder described herein, can be treated by administering to the patient an effective amount of the active compound or a pharmaceutically acceptable prodrug or salt thereof in the presence of a pharmaceutically acceptable canier or dilutent.
- the active materials can be administered by any appropriate route, for example, orally, parenterally, intravenously, intradermally, subcutaneously, or topically, in liquid or solid form.
- a preferred dose of the compound for pestivirus, flavivirus or HCV will be in the range from about 1 to 50 mg/kg, preferably 1 to 20 mg/kg, of body weight per day, more generally 0.1 to about 100 mg per kilogram body weight of the recipient per day. Lower doses may be preferable, for example doses of 0.5-100 mg, 0.5-50 mg, 0.5-10 mg, or 0.5-5 mg per kilogram body weight per day. Even lower doses may be useful, and thus ranges can include from 0.1-0.5 mg per kilogram body weight per day.
- the effective dosage range of the pharmaceutically acceptable salts and prodrugs can be calculated based on the weight of the parent nucleoside to be delivered. If the salt or prodrug exhibits activity in itself, the effective dosage can be estimated as above using the weight of the salt or prodrug, or by other means known to those skilled in the art.
- the compound is conveniently administered in unit any suitable dosage form, including but not limited to one containing 7 to 3000 mg, preferably 70 to 1400 mg of active ingredient per unit dosage form.
- An oral dosage of 50-1000 mg is usually convenient, including in one or multiple dosage forms of 50, 100, 200, 250, 300, 400, 500, 600, 700, 800, 900 or 1000 mgs.
- Lower doses may be preferable, for example from 10-100 or 1-50 mg.
- Also contemplated are doses of 0.1-50 mg, or 0.1-20 mg or 0.1-10.0 mg.
- lower doses may be utilized in the case of administration by a non-oral route, as, for example, by injection or inhalation.
- the active ingredient should be administered to achieve peak plasma concentrations of the active compound of from about 0.2 to 70 ⁇ M, preferably about 1.0 to
- compositions should be adjusted over time according to the individual need and the professional judgment of the person administering or supervising the administration of the compositions, and that the concentration ranges set forth herein are exemplary only and are not intended to limit the scope or practice of the claimed composition.
- the active ingredient may be administered at once, or may be divided into a number of smaller doses to be administered at varying intervals of time.
- a prefened mode of administration of the active compound is oral.
- Oral compositions will generally include an inert diluent or an edible canier. They may be enclosed in gelatin capsules or compressed into tablets.
- the active compound can be inco ⁇ orated with excipients and used in the form of tablets, troches, or capsules.
- Pharmaceutically compatible binding agents, and/or adjuvant materials can e included as part of the composition.
- the tablets, pills, capsules, troches and the like can contain any of the following ingredients, or compounds of a similar nature: a binder such as microcrystalline cellulose, gum tragacanth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, or corn starch; a lubricant such as magnesium stearate or Sterotes; a glidant such as colloidal silicon dioxide; a sweetening agent such as sucrose or saccharin; or a flavoring agent such as peppermint, methyl salicylate, or orange flavoring.
- a binder such as microcrystalline cellulose, gum tragacanth or gelatin
- an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, or corn starch
- a lubricant such as magnesium stearate or Sterotes
- a glidant such as colloidal silicon dioxide
- the compound can be administered as a component of an elixir, suspension, syrup, wafer, chewing gum or the like.
- a syrup may contain, in addition to the active compounds, sucrose as a sweetening agent and certain preservatives, dyes and colorings and flavors.
- the compound or a pharmaceutically acceptable prodrug or salts thereof can also be mixed with other active materials that do not impair the desired action, or with materials that supplement the desired action, such as antibiotics, antifungals, anti-inflammatories, or other antivirals, including other nucleoside compounds.
- Solutions or suspensions used for parenteral, intradermal, sucutaneous, or topical application can include the following components: a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerine, propylene glycol or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl parabens; antioxidants such as ascorbic acid or sodium bisulfite; chelating agents such as ethylenediaminetefraacetic acid; buffers such as acetates, citrates or phosphates and agents for the adjustment of tonicity such as sodium chloride or dextrose.
- the parental preparation can be enclosed in ampoules, disposable syringes or multiple dose vials made of glass or plastic.
- prefened caniers are physiological saline or phosphate buffered saline (PBS).
- the active compounds are prepared with caniers that will protect the compound against rapid elimination from the body, such as a controlled release formulation, including implants and microencapsulated delivery systems, biodegradable, biocompatible polymers can be used, such as ethylene vinyl acetate, polyanhydrides, polyglycolic acid, collagen, polyorthoesters and polylactic acid. Methods for preparation of such formulations will be apparent to those skilled in the art. The materials can also be obtained commercially from Alza Co ⁇ oration.
- Liposomal suspensions including liposomes targeted to infected cells with monoclonal antibodies to viral antigens are also prefened as pharmaceutically acceptable carriers. These may be prepared according to methods known to those skilled in the art, for example, as described in U.S. Patent No. 4,522,811 (which is inco ⁇ orated herein by reference in its entirety).
- liposome formulations may be prepared by dissolving appropriate lipid(s) (such as stearoyl phosphatidyl ethanolamine, stearoyl phosphatidyl choline, arachadoyl phosphatidyl choline, and cholesterol) in an inorganic solvent that is then evaporated, leaving behind a thin film of dried lipid on the surface of the container.
- An aqueous solution of the active compound or its monophosphate, diphosphate, and/or triphosphate derivatives is then introduced into the container.
- the container is then swirled by hand to free lipid material from the sides of the container and to disperse lipid aggregates, thereby forming the liposomal suspension.
- nucleosides of the present invention can be synthesized by any means known in the art.
- the synthesis of the present nucleosides can be achieved by either alkylating the appropriately modified sugar, followed by glycosylation or glycosylation followed by alkylation of the nucleoside.
- the following non-limiting embodiments illustrate some general methodology to obtain the nucleosides of the present invention.
- R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , Y, W 1 , W 2 , W 3 , X, X 1 , X 2 and X 3 are as defined herein can be prepared by one of the following general methods.
- the lactone can be purchased or can be prepared by any known means including standard epimerization, substitution and cyclization techniques.
- the lactone can be optionally protected with a suitable protecting group, preferably with an acyl or silyl group, by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991.
- the protected lactone can then be coupled with a suitable coupling agent, such as an organometallic carbon nucleophile, such as a Grignard reagent, an organolithium, lithium dialkylcopper or R 6 - SiMe 3 in TBAF with the appropriate non-protic solvent at a suitable temperature, to give the 1' -alkylated sugar.
- a suitable coupling agent such as an organometallic carbon nucleophile, such as a Grignard reagent, an organolithium, lithium dialkylcopper or R 6 - SiMe 3 in TBAF with the appropriate non
- the optionally activated sugar can then be coupled to the BASE by methods well known to those skilled in the art, as taught by Townsend Chemistry of Nucleosides and Nucleotides, Plenum Press, 1994.
- an acylated sugar can be coupled to a silylated base with a Lewis acid, such as tin tetrachloride, titanium tetrachloride or trimethylsilyltriflate in the appropriate solvent at a suitable temperature.
- a Lewis acid such as tin tetrachloride, titanium tetrachloride or trimethylsilyltriflate
- the nucleoside can be deprotected by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991.
- the l'-C-branched ribonucleoside is desired.
- the synthesis of a ribonucleoside is shown in Scheme 1.
- deoxyribo-nucleoside is desired.
- the formed ribonucleoside can optionally be protected by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991, and then the 2'- OH can be reduced with a suitable reducing agent.
- the 2 '-hydroxyl can be activated to facilitate reduction; i.e. via the Barton reduction.
- the key starting material for this process is an appropriately substituted hexose.
- the hexose can be purchased or can be prepared by any known means including standard epimerization (e.g. via alkaline treatment), substimtion and coupling techniques.
- the hexose can be selectively protected to give the appropriate hexa-furanose, as taught by Townsend Chemistry of Nucleosides and Nucleotides, Plenum Press, 1994.
- the 1' -hydroxyl can be optionally activated to a suitable leaving group such as an acyl group or a halogen via acylation or halogenation, respectively.
- a suitable leaving group such as an acyl group or a halogen via acylation or halogenation, respectively.
- the optionally activated sugar can then be coupled to the BASE by methods well known to those skilled in the art, as taught by Townsend Chemistry of Nucleosides and Nucleotides, Plenum Press, 1994.
- an acylated sugar can be coupled to a silylated base with a Lewis acid, such as tin tetrachloride, titanium tetrachloride or trimethylsilyltriflate in the appropriate solvent at a suitable temperature.
- a halo-sugar can be coupled to a silylated base with the presence of trimethylsilyltriflate.
- the l'-CH 2 -OH if protected, can be selectively deprotected by methods well known in the art.
- the resultant primary hydroxyl can be functionalized to yield various C-branched nucleosides.
- the primary hydroxyl can be reduced to give the methyl, using a suitable reducing agent.
- the hydroxyl can be activated prior to reduction to facilitate the reaction; i.e. via the Barton reduction.
- the primary hydroxyl can be oxidized to the aldehyde, then coupled with a carbon nucleophile, such as a Grignard reagent, an organolithium, lithium dialkylcopper or R 6 -SiMe 3 in TBAF with the appropriate non-protic solvent at a suitable temperature.
- a carbon nucleophile such as a Grignard reagent, an organolithium, lithium dialkylcopper or R 6 -SiMe 3 in TBAF with the appropriate non-protic solvent at a suitable temperature.
- the 1 '-C-branched ribonucleoside is desired.
- the synthesis of a ribonucleoside is shown in Scheme 2.
- deoxyribo-nucleoside is desired.
- the formed ribonucleoside can optionally be protected by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991, and then the 2'- OH can be reduced with a suitable reducing agent.
- the 2 '-hydroxyl can be activated to facilitate reduction; i.e. via the Barton reduction.
- L-enantiomers conesponding to the compounds of the invention can be prepared following the same general methods (1 or 2), beginning with the conesponding L-sugar or nucleoside L-enantiomer as starting material.
- R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 9 , R 10 , Y, W 1 , W 2 , W 3 , X, X 1 , X 2 and X 3 are as defined herein can be prepared by one of the following general methods. 1. Glycosylation of the nucleobase with an appropriately modified sugar
- the key starting material for this process is an appropriately substituted sugar with a 2' -OH and 2'-H, with the appropriate leaving group (LG), for example an acyl group or a halogen.
- LG leaving group
- the sugar can be purchased or can be prepared by any known means including standard epimerization, substitution, oxidation and reduction techniques.
- the substimted sugar can then be oxidized with the appropriate oxidizing agent in a compatible solvent at a suitable temperature to yield the 2 '-modified sugar.
- Possible oxidizing agents are Jones reagent (a mixture of chromic acid and sulfuric acid), Collins' s reagent (dipyridine Cr(VI) oxide, Corey's reagent (pyridinium chlorochromate), pyridinium dichromate, acid dichromate, potassium permanganate, MnO* ruthenium tetroxide, phase transfer catalysts such as chromic acid or permanganate supported on a polymer, Cl 2 -pyridine, H 2 O 2 - ammonium molybdate, NaBr0 2 -CAN, NaOCl in HOAc, copper chromite, copper oxide, Raney nickel, palladium acetate, Meerwin-Pondorf-Verley reagent (aluminum t-butoxide with another ketone) and N-bromosuccinimide.
- Jones reagent a mixture of chromic acid and sulfuric acid
- Collins' s reagent dipyridine Cr(VI) oxide
- an organometallic carbon nucleophile such as a Grignard reagent, an organolithium, lithium dialkylcopper or R 6 -SiMe 3 in TBAF with the ketone with the appropriate non-protic solvent at a suitable temperature, yields the 2'-alkylated sugar.
- the alkylated sugar can be optionally protected with a suitable protecting group, preferably with an acyl or silyl group, by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second
- the optionally protected sugar can then be coupled to the BASE by methods well known to those skilled in the art, as taught by Townsend Chemistry of Nucleosides and Nucleotides, Plenum Press, 1994.
- an acylated sugar can be coupled to a silylated base with a Lewis acid, such as tin tetrachloride, titanium tetrachloride or trimethylsilyltriflate in the appropriate solvent at a suitable temperature.
- a halo-sugar can be coupled to a silylated base with the presence of trimethylsilyltriflate.
- nucleoside can be deprotected by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis. John Wiley and Sons, Second Edition, 1991.
- the 2 '-C-branched ribonucleoside is desired.
- the synthesis of a ribonucleoside is shown in Scheme 3.
- deoxyribo-nucleoside is desired.
- the formed ribonucleoside can optionally be protected by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991, and then the 2'- OH can be reduced with a suitable reducing agent.
- the 2 '-hydroxyl can be activated to facilitate reduction; i.e. via the Barton reduction.
- the key starting material for this process is an appropriately substimted nucleoside with a 2'-OH and 2'-H.
- the nucleoside can be purchased or can be prepared by any known means including standard coupling techniques.
- the nucleoside can be optionally protected with suitable protecting groups, preferably with acyl or silyl groups, by methods well known to those skilled in the art, as taught by Greene et al Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991.
- the appropriately protected nucleoside can then be oxidized with the appropriate oxidizing agent in a compatible solvent at a suitable temperature to yield the 2 '-modified sugar.
- Possible oxidizing agents are Jones reagent (a mixture of chromic acid and sulfuric acid), Collins's reagent (dipyridine Cr(VI) oxide, Corey's reagent (pyridinium chlorochromate), pyridinium dichromate, acid dichromate, potassium permanganate, MhO* ruthenium tetroxide, phase transfer catalysts such as chromic acid or permanganate supported on a polymer, Cl 2 -pyridine, H 2 0 2 -ammonium molybdate, NaBr0 2 -CAN, NaOCl in HOAc, copper chromite, copper oxide, Raney nickel, palladium acetate, Meerwin- Pondorf-Verley reagent (aluminum t-butoxide with another ketone) and N- bromosuccinimide .
- nucleoside can be deprotected by methods well known to those skilled in the art, as taught by GreeneGreene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991.
- the 2 '-C-branched ribonucleoside is desired.
- the synthesis of a ribonucleoside is shown in Scheme 4.
- deoxyribo-nucleoside is desired.
- the formed ribonucleoside can optionally be protected by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991, and then the 2'- OH can be reduced with a suitable reducing agent.
- the 2 '-hydroxyl can be activated to facilitate reduction; i.e. via the Barton reduction.
- the L-enantiomers are desired. Therefore, the L-enantiomers can be conesponding to the compounds of the mvention can be prepared following the same foregoing general methods, beginning with the conesponding L-sugar or nucleoside L-enantiomer as starting material.
- R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , Y, W 1 , W 2 , W 3 , X, X 1 , X 2 and X 3 are as defined herein can be prepared by one of the following general methods.
- the key starting material for this process is an appropriately substituted sugar with a 3' -OH and 3'-H, with the appropriate leaving group (LG), for example an acyl group or a halogen.
- the sugar can be purchased or can be prepared by any known means including standard epimerization, substimtion, oxidation and reduction techniques.
- the substituted sugar can then be oxidized with the appropriate oxidizing agent in a compatible solvent at a suitable temperature to yield the 3 '-modified sugar.
- Possible oxidizing agents are Jones reagent (a mixture of chromic acid and sulfuric acid), Collins's reagent (dipyridine Cr(VI) oxide, Corey's reagent (pyridinium chlorochromate), pyridinium dichromate, acid dichromate, potassium permanganate, MnO* ruthenium tetroxide, phase transfer catalysts such as chromic acid or permanganate supported on a polymer, Cl 2 -pyridine, H 2 0 2 - ammonium molybdate, NaBr0 2 -CAN, NaOCl in HOAc, copper chromite, copper oxide, Raney nickel, palladium acetate, Meerwin-Pondorf-Verley reagent (aluminum t-butoxide with another ketone) and N-bromosuccinimide.
- Jones reagent a mixture of chromic acid and sulfuric acid
- Collins's reagent dipyridine Cr(VI) oxide
- an organometallic carbon nucleophile such as a Grignard reagent, an organolithium, lithium dialkylcopper or R 6 -SiMe 3 in TBAF with the ketone with the appropriate non-protic solvent at a suitable temperature, yields the 3 '-C-branched sugar.
- the 3 '-C-branched sugar can be optionally protected with a suitable protecting group, preferably with an acyl or silyl group, by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons,
- the optionally protected sugar can then be coupled to the BASE by methods well known to those skilled in the art, as taught by Townsend Chemistry of Nucleosides and Nucleotides, Plenum Press, 1994.
- an acylated sugar can be coupled to a silylated base with a Lewis acid, such as tin tetrachloride, titanium tetrachloride or trimethylsilylfriflate in the appropriate solvent at a suitable temperature.
- a halo-sugar can be coupled to a silylated base with the presence of trimethylsilyltriflate.
- nucleoside can be deprotected by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991.
- the 3 '-C-branched ribonucleoside is desired.
- the synthesis of a ribonucleoside is shown in Scheme 5.
- deoxyribo-nucleoside is desired.
- the formed ribonucleoside can optionally be protected by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991, and then the 2'- OH can be reduced with a suitable reducing agent.
- the 2'-hydroxyl can be activated to facilitate reduction; i.e. via the Barton reduction.
- the key starting material for this process is an appropriately substimted nucleoside with a 3' -OH and 3'-H.
- the nucleoside can be purchased or can be prepared by any known means including standard coupling techniques.
- the nucleoside can be optionally protected with suitable protecting groups, preferably with acyl or silyl groups, by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis. John Wiley and Sons, Second Edition, 1991.
- the appropriately protected nucleoside can then be oxidized with the appropriate oxidizing agent in a compatible solvent at a suitable temperamre to yield the 2' -modified sugar.
- Possible oxidizing agents are Jones reagent (a mixture of chromic acid and sulfuric acid), Collins's reagent (dipyridine Cr(VI) oxide, Corey's reagent (pyridinium chlorochromate), pyridinium dichromate, acid dichromate, potassium permanganate, MnO* rathenium tetroxide, phase transfer catalysts such as chromic acid or permanganate supported on a polymer, Cl 2 -pyridine, H 2 0 2 -ammonium molybdate, NaBr0 2 -CAN, NaOCl in HO Ac, copper chromite, copper oxide, Raney nickel, palladium acetate, Meerwin-
- Pondorf-Verley reagent (aluminum t-butoxide with another ketone) and N- bromosuccinimide.
- nucleoside can be deprotected by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991.
- the 3 '-C-branched ribonucleoside is desired.
- the synthesis of a ribonucleoside is shown in Scheme 6.
- deoxyribo-nucleoside is desired.
- the formed ribonucleoside can optionally be protected by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991, and then the 2'-
- OH can be reduced with a suitable reducing agent.
- the 2'-hydroxyl can be activated to facilitate reduction; i.e. via the Barton reduction.
- the L-enantiomers are desired. Therefore, the L-enantiomers can be conesponding to the compounds of the invention can be prepared following the same foregoing general methods, beginning with the conesponding L-sugar or nucleoside L-enantiomer as starting material. D. General Synthesis of 4 '-C-Branched Nucleosides
- R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R s , R 9 , R 10 , Y, W 1 , W 2 , W 3 , X, X 1 , X 2 and X 3 are as defined herein can be prepared by one of the following general methods. 1. Modification from the pentodialdo-furanose
- the key starting material for this process is an appropriately substituted pentodialdo- furanose.
- the pentodialdo-furanose can be purchased or can be prepared by any known means including standard epimerization, substimtion and cyclization techniques.
- the pentodialdo-furanose is prepared from the appropriately substimted hexose.
- the hexose can be purchased or can be prepared by any known means including standard epimerization (e.g. via alkaline treatment), substimtion and coupling techniques.
- the hexose can be either in the furanose form, or cyclized via any means known in the art, such as methodology taught by Townsend Chemistry of Nucleosides and Nucleotides, Plenum Press, 1994, preferably by selectively protecting the hexose, to give the appropriate hexafuranose.
- the 4'-hydroxymethylene of the hexafuranose then can be oxidized with the appropriate oxidizing agent in a compatible solvent at a suitable temperamre to yield the 4'- aldo-modified sugar.
- Possible oxidizing agents are Swern reagents, Jones reagent (a mixture of chromic acid and sulfuric acid), Collins 's reagent (dipyridine Cr(VI) oxide, Corey's reagent (pyridinium chlorochromate), pyridinium dichromate, acid dichromate, potassium permanganate, MnO* ruthenium tetroxide, phase transfer catalysts such as chromic acid or permanganate supported on a polymer, Cl 2 -pyridine, H 2 0 2 -ammonium molybdate, NaBrO 2 -CAN, NaOCl in HOAc, copper chromite, copper oxide, Raney nickel, palladium acetate, Meerwin-Pondorf-Verley reagent (alumin
- the pentodialdo-furanose can be optionally protected with a suitable protecting group, preferably with an acyl or silyl group, by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991.
- a suitable protecting group preferably with an acyl or silyl group
- the protected pentodialdo-furanose can then be coupled with a suitable electrophilic alkyl, halogeno-alkyl (i.e. CF 3 ), alkenyl or alkynyl (i.e. allyl), to obtain the 4'-alkylated sugar.
- the protected pentodialdo-furanose can be coupled with the conesponding carbonyl, such as formaldehyde, in the presence of a base, such as sodium hydroxide, with the appropriate polar solvent, such as dioxane, at a suitable temperamre, which can then be reduced with an appropriate reducing agent to give the 4 '-alkylated sugar.
- the reduction is canied out using PhOC(S)Cl, DMAP, preferably in acetonitrile at room temperamre, followed by treatment of ACC ⁇ and TMSS refluxed in toluene.
- the optionally activated sugar can then be coupled to the BASE by methods well known to those skilled in the art, as taught by Townsend Chemistry of Nucleosides and Nucleotides, Plenum Press, 1994.
- an acylated sugar can be coupled to a silylated base with a Lewis acid, such as tin tetrachloride, titanium tetrachloride or trimethylsilyltriflate in the appropriate solvent at a suitable temperamre.
- a Lewis acid such as tin tetrachloride, titanium tetrachloride or trimethylsilyltriflate in the appropriate solvent at a suitable temperamre.
- the nucleoside can be deprotected by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis. John Wiley and Sons, Second Edition, 1991.
- the 4 '-C-branched ribonucleoside is desired.
- deoxyribonucleoside is desired.
- a formed ribo-nucleoside can optionally be protected by methods well known to those skilled in the art, as taught by Greene et al. Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991, and then the 2'-OH can be reduced with a suitable reducing agent.
- the 2 '-hydroxyl can be activated to facilitate reduction; i.e. via the Barton reduction.
- the L-enantiomers are desired. Therefore, the L-enantiomers can be conesponding to the compounds of the invention can be prepared following the same foregoing general methods, beginning with the conesponding L- pentodialdo-furanose as starting material.
- the key starting material for this process is an appropriately substituted 1', 2', 3' or 4'-branched ⁇ -D or ⁇ -L nucleosides.
- the branched nucleoside can be purchased or can be prepared by any known means including the techniques disclosed herein.
- the branched nucleoside can be optionally protected with a suitable protecting group, preferably with a silyl group, by methods well known to those skilled in the art, as taught by Greene et al.
- the protected branched nucleoside can then be coupled with a suitable acyl doner, such as an acyl chloride and/or an acyl anhydride with the appropriate protic or aprotic solvent at a suitable temperamre, to give the 2' and/or 3' prodrug of 1', 2', 3' or 4 '-branched ⁇ -D or ⁇ -L nucleoside.
- a suitable acyl doner such as an acyl chloride and/or an acyl anhydride with the appropriate protic or aprotic solvent at a suitable temperamre
- the protected branched nucleoside can then be coupled with a suitable acyl, such as a carboxylic acid, such as alkanoic acid and/or amino acid residue, optionally with a suitable coupling agent, with the appropriate aprotic solvent at a suitable temperature, to give the 2' and/or 3' prodrug of 1', 2', 3' or 4 '-branched ⁇ -D or ⁇ -L nucleoside.
- a suitable acyl such as a carboxylic acid, such as alkanoic acid and/or amino acid residue
- a suitable coupling agent with the appropriate aprotic solvent at a suitable temperature
- Possible coupling reagents are any reagents that promote coupling, including but are not limiting to, Mitsunobu reagents (e.g. diisopropyl azodicarboxylate and diethyl azodicarboxylate) with friphenylphosphine or various carbodiimides.
- simple amino-alcohols can be esterified using acid chlorides in refluxing acetonitrile-benzene mixture (See Scheme 7 below: Synthetic Communications, 1978, 8(5), 327-333; hereby incorporated by reference).
- esterification can be achieved using an anhydride, as described in J Am. Chem. Soc, 1999, 727(24), 5661-5664, which is hereby inco ⁇ ortated by reference. See Figures 2, 3 and 4.
- ACN acetonitrile
- IR spectra were measured on a Nicolet 51 OP FT-IR spectrometer. Mass spectra were recorded on a Micromass Autospec high-resolution mass spectrometer. TLC were performed on Uniplates (silica gel) purchased from Analtech Co. Column chromatography was performed using either silica gel-60 (220-440 mesh) for flash chromatography or silica gel G (TLC grade, > 440 mesh) for vacuum flash column chromatography. UV spectra were obtained on a Beckman DU 650 spectrophotometer.
- Elemental analysis was performed by Atlantic Microlab, Inc., Norcross, GA, or Galbraith Laboratories, Inc., Knoxville, TN.
- HPLC was performed with a Waters HPLC system (Millipore Corporation, Milford, MA) equipped with a Model 600 controller, a Model 996 photodiode anay detector and a Model 717 plus autosampler. Millennium 2010 software was used for system control, data acquisition and processing.
- nucleosides of Formula XXIV are prepared.
- nucleosides of Formula XXVI are prepared, using the appropriate sugar and pyrimidine or purine bases.
- nucleosides of Formula XXVII are prepared, using the appropriate sugar and pyrimidine or purine bases.
- nucleosides of Formula XXVIII are prepared, using the appropriate sugar and pyrimidine or purine bases.
- nucleosides of Formula XXIX are prepared, using the appropriate sugar and pyrimidine or purine bases.
- Carbonyldiimidazole (377 mg, 2.33 mmol) was added to a solution of N-(tert-butoxycarbonyl)-L-valine (507 mg, 2.33 mmol) in 15 mL of anhydrous tetrahydrofuran.
- nucleosides of Formula XXX are prepared.
- R , 1 1 , ⁇ R>2 , X v l, v X2, and Y are defined herein.
- nucleosides of Formula XXXI are prepared, using the appropriate sugar and pyrimidine bases.
- nucleosides of Formula XXXII are prepared, using the appropriate sugar and pyrimidine or purine bases.
- nucleosides of Formula XXXIII are prepared, using the appropriate sugar and pyrimidine or purine bases.
- nucleosides of Formula XXXIV are prepared, using the appropriate sugar and pyrimidine or purine bases.
- nucleosides of Formula XXXV are prepared, using the appropriate sugar and pyrimidine or purine bases.
- nucleosides of Formula XXXVII are prepared, using the appropriate sugar and pyrimidine bases.
- nucleosides of Formula XXXVIII are prepared, using the appropriate sugar and pyrimidine or purine bases.
- nucleosides of Formula XXXX are prepared, using the appropriate sugar and pyrimidine or purine bases.
- nucleosides of Formula XXXXI are prepared, using the appropriate sugar and pyrimidine or purine bases.
- the title compound can be prepared according to a published procedure (Jones, G. H.; Moffatt, J. G. Oxidation of carbohydrates by the sulfoxide-carbodiimide and related methods. Oxidation with dicyclohexylcarbodiimide-DMSO, diisopropylcarbodiimide- DMSO, acetic anhydride-DMSO, and phosphorus pentoxide-DMSO: in Methods in
- the title compound can be prepared according to a published procedure (Gunic, E.; Girardet, J.-L.; Pietrzkowski, Z.; Esler, C; Wang, G. "Synthesis and cytotoxicity of 4'-C- and 5"-C-substituted Toyocamycins" Bioorg. Med. Chem. 2001, 9, 163-170).
- EXAMPLE 11 PREPARATION OF O-6-DlPHENYLCARBAMOYL-N 2 -ISOBUTYRYL-9-(2,3- DI-O-ACETYL-5-O-BENZOYL-4-C-METHYL- ⁇ -D-RIBOFURANOSYL)-8-METHYLGUANINE -
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SI200332358T SI1523489T1 (en) | 2002-06-28 | 2003-06-27 | Modified 2' and 3' -nucleoside produgs for treating flaviridae infections |
BRPI0312286-7A BR0312286A (en) | 2002-06-28 | 2003-06-27 | 2 'and 3' prodrugs - modified nucleoside for treatment of flaviviridae infections |
CA2490191A CA2490191C (en) | 2002-06-28 | 2003-06-27 | Modified 2' and 3' -nucleoside prodrugs for treating flaviviridae infections |
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AU2003247084A AU2003247084B9 (en) | 2002-06-28 | 2003-06-27 | Modified 2' and 3'-nucleoside prodrugs for treating flaviridae infections |
YUP-1140/04A RS114004A (en) | 2002-06-28 | 2003-06-27 | Modified 2' and 3'-nucleoside produgs for treating flaviridae infections |
DK03761744.6T DK1523489T3 (en) | 2002-06-28 | 2003-06-27 | MODIFIED 2 'AND 3' NUCLEOSIDE PRODUCTS TO TREAT FLAVIRIDA INFECTIONS |
EP03761744.6A EP1523489B1 (en) | 2002-06-28 | 2003-06-27 | Modified 2' and 3' -nucleoside produgs for treating flaviridae infections |
JP2004517158A JP2005533817A (en) | 2002-06-28 | 2003-06-27 | Modified 2 'and 3'-nucleoside prodrugs for the treatment of Flaviviridae virus infection |
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IL16589304A IL165893A0 (en) | 2002-06-28 | 2004-12-21 | Modified 2' and 3'-nucleoside prodrugs for treating flaviridae infections |
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NO20110343A NO20110343A1 (en) | 2002-06-28 | 2011-03-04 | Modified 2 'and 3' nucleoside prodrugs for the treatment of flaviviridae infections |
NO2014019C NO2014019I1 (en) | 2002-06-28 | 2014-07-30 | Sofosbuvir |
CY2014031C CY2014031I2 (en) | 2002-06-28 | 2014-08-12 | MODIFIED 2' AND 3'-NUCLEOSITE PRODRUGS FOR THE TREATMENT OF FLAVIVIRIDAE INFECTIONS |
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---|---|---|---|---|
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WO2005123087A2 (en) | 2004-06-15 | 2005-12-29 | Merck & Co., Inc. | C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase |
US7148349B2 (en) | 2002-10-31 | 2006-12-12 | Metabasis Therapeutics, Inc. | Cyclic phosphate diesters of 1,3-propane-1-aryl diols and their use in preparing prodrugs |
US7157441B2 (en) | 2000-05-23 | 2007-01-02 | Idenix Pharmaceuticals, Inc. | Methods and compositions for treating hepatitis C virus |
WO2007113159A1 (en) | 2006-04-04 | 2007-10-11 | F. Hoffmann-La Roche Ag | 3',5'-di-o-acylated nucleosides for hcv treatment |
US7323449B2 (en) | 2002-07-24 | 2008-01-29 | Merck & Co., Inc. | Thionucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
JP2008514639A (en) * | 2004-09-24 | 2008-05-08 | イデニクス(ケイマン)リミテツド | Methods and compositions for treating flavivirus, pestivirus and hepacivirus infections |
WO2008085508A2 (en) | 2007-01-05 | 2008-07-17 | Merck & Co., Inc. | Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection |
US7585851B2 (en) | 2000-06-15 | 2009-09-08 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
WO2009129120A2 (en) | 2008-04-15 | 2009-10-22 | Rfs Pharma, Llc | Nucleoside derivatives for treatment of caliciviridae infections, including norovirus infections |
EP2141172A1 (en) | 2008-07-01 | 2010-01-06 | Ortho Biotech Products L.P. | Cyclopropyl polymerase inhibitors |
US7666855B2 (en) | 2004-02-13 | 2010-02-23 | Metabasis Therapeutics, Inc. | 2′-C-methyl nucleoside derivatives |
US7666856B2 (en) | 2006-10-10 | 2010-02-23 | Medivir Ab | Antiviral nucleosides |
WO2010066699A1 (en) * | 2008-12-08 | 2010-06-17 | Centocor Ortho Biotech Products L.P. | Uracyl cyclopropyl nucleotides |
US7754699B2 (en) | 2005-12-09 | 2010-07-13 | Roche Palo Alto Llc | Antiviral nucleosides |
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WO2010084115A2 (en) | 2009-01-20 | 2010-07-29 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Antiviral agents |
US7767660B2 (en) | 2006-12-20 | 2010-08-03 | Istituto Di Richerche Di Biologia Molecolare P. Angeletti Spa | Antiviral indoles |
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WO2010101967A2 (en) | 2009-03-04 | 2010-09-10 | Idenix Pharmaceuticals, Inc. | Phosphothiophene and phosphothiazole hcv polymerase inhibitors |
US7824851B2 (en) | 2002-11-15 | 2010-11-02 | Idenix Pharmaceuticals, Inc. | 2′-branched nucleosides and Flaviviridae mutation |
US7858654B2 (en) | 2007-12-17 | 2010-12-28 | Roche Palo Alto Llc | Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists |
US7879797B2 (en) | 2005-05-02 | 2011-02-01 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
WO2011014487A1 (en) | 2009-07-30 | 2011-02-03 | Merck Sharp & Dohme Corp. | Hepatitis c virus ns3 protease inhibitors |
WO2011017389A1 (en) | 2009-08-05 | 2011-02-10 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv |
US7902202B2 (en) | 2006-12-28 | 2011-03-08 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
WO2011058084A1 (en) | 2009-11-14 | 2011-05-19 | F. Hoffmann-La Roche Ag | Biomarkers for predicting rapid response to hcv treatment |
WO2011063076A1 (en) | 2009-11-19 | 2011-05-26 | Itherx Pharmaceuticals, Inc. | Methods of treating hepatitis c virus with oxoacetamide compounds |
WO2011067195A1 (en) | 2009-12-02 | 2011-06-09 | F. Hoffmann-La Roche Ag | Biomarkers for predicting sustained response to hcv treatment |
WO2011075615A1 (en) | 2009-12-18 | 2011-06-23 | Idenix Pharmaceuticals, Inc. | 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors |
US7973040B2 (en) | 2008-07-22 | 2011-07-05 | Merck Sharp & Dohme Corp. | Macrocyclic quinoxaline compounds as HCV NS3 protease inhibitors |
US7989637B2 (en) | 2007-12-17 | 2011-08-02 | Roche Palo Alto Llc | Triazole-substituted arylamides as P2X3 and P2X2/3 antagonists |
US7989438B2 (en) | 2007-07-17 | 2011-08-02 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Therapeutic compounds |
WO2011123586A1 (en) | 2010-04-01 | 2011-10-06 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
US8048905B2 (en) | 2007-12-17 | 2011-11-01 | Roche Palo Alto Llc | Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists |
US8058260B2 (en) | 2006-05-22 | 2011-11-15 | Xenoport, Inc. | 2′-C-methyl-ribofuranosyl cytidine prodrugs, pharmaceutical compositions and uses thereof |
US8093275B2 (en) | 2009-06-22 | 2012-01-10 | Roche Palo Alto Llc | Oxazolone and pyrrolidinone-substituted pryidine amides as P2X3 and P2X2/3 antagonists |
US8101595B2 (en) | 2006-12-20 | 2012-01-24 | Istituto di Ricerche di Biologia Molecolare P. Angletti SpA | Antiviral indoles |
US8138164B2 (en) | 2006-10-24 | 2012-03-20 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
US8178520B2 (en) | 2006-05-15 | 2012-05-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Macrocyclic compounds as antiviral agents |
WO2012080050A1 (en) | 2010-12-14 | 2012-06-21 | F. Hoffmann-La Roche Ag | Solid forms of a phenoxybenzenesulfonyl compound |
US8216999B2 (en) | 2005-07-20 | 2012-07-10 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
EP2476690A1 (en) | 2008-07-02 | 2012-07-18 | IDENIX Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
US8227431B2 (en) | 2008-03-17 | 2012-07-24 | Hetero Drugs Limited | Nucleoside derivatives |
WO2012109398A1 (en) | 2011-02-10 | 2012-08-16 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating hcv infections |
US8278322B2 (en) | 2005-08-01 | 2012-10-02 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
WO2012135581A1 (en) | 2011-03-31 | 2012-10-04 | Idenix Pharmaceuticals, Inc. | Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor |
US8283383B2 (en) | 2009-06-22 | 2012-10-09 | Roche Palo Alto Llc | Biphenyl amides as P2X3 and P2X2/3 antagonists |
WO2012142523A2 (en) | 2011-04-13 | 2012-10-18 | Gilead Sciences, Inc. | 1'-substituted pyrimidine n-nucleoside analogs for antiviral treatment |
US8309540B2 (en) | 2006-10-24 | 2012-11-13 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
WO2012154321A1 (en) | 2011-03-31 | 2012-11-15 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
US8314062B2 (en) | 2006-06-23 | 2012-11-20 | Instituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Macrocyclic compounds as antiviral agents |
US8329664B2 (en) | 2006-05-09 | 2012-12-11 | University College Cardiff Consultants Limited | Anti-viral pyrimidine nucleoside derivatives |
US8377874B2 (en) | 2006-10-27 | 2013-02-19 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
US8377873B2 (en) | 2006-10-24 | 2013-02-19 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
WO2013039855A1 (en) | 2011-09-12 | 2013-03-21 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
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US8440673B2 (en) | 2007-12-17 | 2013-05-14 | Roche Palo Alto Llc | Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists |
WO2013074386A2 (en) | 2011-11-15 | 2013-05-23 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
US8461107B2 (en) | 2008-04-28 | 2013-06-11 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
US8470870B2 (en) | 2008-03-27 | 2013-06-25 | Idenix Pharmaceuticals, Inc. | Solid forms of an anti-HIV phosphoindole compound |
US8476457B2 (en) | 2009-06-22 | 2013-07-02 | Roche Palo Alto Llc | Indole, indazole and benzimidazole arylamides as P2X3 and P2X2/3 antagonists |
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WO2013133927A1 (en) | 2012-02-13 | 2013-09-12 | Idenix Pharmaceuticals, Inc. | Pharmaceutical compositions of 2'-c-methyl-guanosine, 5'-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl n-(phenylmethyl)phosphoramidate] |
US8551973B2 (en) | 2008-12-23 | 2013-10-08 | Gilead Pharmasset Llc | Nucleoside analogs |
US8580765B2 (en) | 2007-03-30 | 2013-11-12 | Gilead Pharmasset Llc | Nucleoside phosphoramidate prodrugs |
WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
WO2013177219A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | D-amino acid compounds for liver disease |
WO2013177195A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphate prodrugs for hcv infection |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US8623901B2 (en) | 2009-03-31 | 2014-01-07 | Boehringer Ingelheim International Gmbh | Compounds for the treatment of CNS disorders |
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WO2014058801A1 (en) | 2012-10-08 | 2014-04-17 | Idenix Pharmaceuticals, Inc. | 2'-chloro nucleoside analogs for hcv infection |
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WO2014078436A1 (en) | 2012-11-14 | 2014-05-22 | Idenix Pharmaceuticals, Inc. | D-alanine ester of sp-nucleoside analog |
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WO2014099941A1 (en) | 2012-12-19 | 2014-06-26 | Idenix Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
WO2014123795A2 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
WO2014123794A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
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WO2014137926A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | 3'-deoxy nucleosides for the treatment of hcv |
WO2014137930A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | Thiophosphate nucleosides for the treatment of hcv |
WO2014148949A1 (en) | 2013-03-22 | 2014-09-25 | Асави, Ллс | Alkyl 2-{[(2r,3s,5r)-5-(4-amino-2-oxo-2н-pyrimidin-1-yl)-3-hydroxy- tetrahydro-furan-2-yl-methoxy]-phenoxy-phosphoryl-amino}-propionates, nucleoside inhibitors of hcv ns5b rna-polymerase, and methods for producing and use thereof |
WO2014165542A1 (en) | 2013-04-01 | 2014-10-09 | Idenix Pharmaceuticals, Inc. | 2',4'-fluoro nucleosides for the treatment of hcv |
US8859756B2 (en) | 2010-03-31 | 2014-10-14 | Gilead Pharmasset Llc | Stereoselective synthesis of phosphorus containing actives |
US8877731B2 (en) | 2010-09-22 | 2014-11-04 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
US8895531B2 (en) | 2006-03-23 | 2014-11-25 | Rfs Pharma Llc | 2′-fluoronucleoside phosphonates as antiviral agents |
WO2014197578A1 (en) | 2013-06-05 | 2014-12-11 | Idenix Pharmaceuticals, Inc. | 1',4'-thio nucleosides for the treatment of hcv |
US8912201B2 (en) | 2010-08-12 | 2014-12-16 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
US8912321B2 (en) | 2006-10-10 | 2014-12-16 | Gilead Pharmasset Llc | Preparation of nucleosides ribofuranosyl pyrimidines |
US8927569B2 (en) | 2007-07-19 | 2015-01-06 | Merck Sharp & Dohme Corp. | Macrocyclic compounds as antiviral agents |
WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
WO2015042375A1 (en) | 2013-09-20 | 2015-03-26 | Idenix Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
WO2015054465A1 (en) * | 2013-10-11 | 2015-04-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
WO2015061683A1 (en) | 2013-10-25 | 2015-04-30 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate and d-alanine thiophosphoramidate pronucleotides of nucleoside compounds useful for the treatment of hcv |
WO2015066370A1 (en) | 2013-11-01 | 2015-05-07 | Idenix Pharmaceuticals, Inc. | D-alanine phosphoramidate pronucleotides of 2'-methyl 2'-fluoro guanosine nucleoside compounds for the treatment of hcv |
WO2015081297A1 (en) | 2013-11-27 | 2015-06-04 | Idenix Pharmaceuticals, Inc. | 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection |
WO2015095419A1 (en) | 2013-12-18 | 2015-06-25 | Idenix Pharmaceuticals, Inc. | 4'-or nucleosides for the treatment of hcv |
US9067945B2 (en) | 2002-08-23 | 2015-06-30 | Boehringer Ingehleim International GmbH | Selective phosphodiesterase 9A inhibitors as medicaments for improving cognitive processes |
US9073960B2 (en) | 2011-12-22 | 2015-07-07 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US9079905B2 (en) | 2008-09-08 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Compounds for the treatment of CNS disorders |
WO2015134561A1 (en) | 2014-03-05 | 2015-09-11 | Idenix Pharmaceuticals, Inc. | Pharmaceutical compositions comprising a 5,5-fused heteroarylene flaviviridae inhibitor and their use for treating or preventing flaviviridae infection |
WO2015134780A1 (en) | 2014-03-05 | 2015-09-11 | Idenix Pharmaceuticals, Inc. | Solid prodrug forms of 2'-chloro-2'-methyl uridine for hcv |
WO2015134560A1 (en) | 2014-03-05 | 2015-09-11 | Idenix Pharmaceuticals, Inc. | Solid forms of a flaviviridae virus inhibitor compound and salts thereof |
WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
US9243022B2 (en) | 2012-12-21 | 2016-01-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US9447132B2 (en) | 2013-04-12 | 2016-09-20 | Achillion Pharmaceuticals, Inc. | Highly active nucleoside derivative for the treatment of HCV |
US9738661B2 (en) | 2006-10-27 | 2017-08-22 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
US9828410B2 (en) | 2015-03-06 | 2017-11-28 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment |
US9845336B2 (en) | 2012-05-25 | 2017-12-19 | Janssen Sciences Ireland Uc | Uracyl spirooxetane nucleosides |
US9968628B2 (en) | 2000-05-26 | 2018-05-15 | Idenix Pharmaceuticals Llc | Methods and compositions for treating flaviviruses and pestiviruses |
US9994600B2 (en) | 2014-07-02 | 2018-06-12 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses therof |
US10039779B2 (en) | 2013-01-31 | 2018-08-07 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
WO2018217884A1 (en) * | 2017-05-23 | 2018-11-29 | Regents Of The University Of Minnesota | Antibacterial agents including histidine kinase inhibitors |
US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
US10449210B2 (en) | 2014-02-13 | 2019-10-22 | Ligand Pharmaceuticals Inc. | Prodrug compounds and their uses |
US10456414B2 (en) | 2011-09-16 | 2019-10-29 | Gilead Pharmasset Llc | Methods for treating HCV |
US10485815B2 (en) | 2012-03-21 | 2019-11-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
EP3750544A2 (en) | 2011-11-30 | 2020-12-16 | Emory University | Jak inhibitors for use in the prevention or treatment of viral infection |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
US10946033B2 (en) | 2016-09-07 | 2021-03-16 | Atea Pharmaceuticals, Inc. | 2′-substituted-N6-substituted purine nucleotides for RNA virus treatment |
US11116783B2 (en) | 2013-08-27 | 2021-09-14 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
WO2021221983A1 (en) * | 2020-04-28 | 2021-11-04 | Southlake Pharmaceuticals, Inc. | Interferon tau as antiviral therapy |
US11166973B2 (en) | 2013-09-11 | 2021-11-09 | Emory University | Substituted nucleotides and nucleosides for treating viral infections |
US11690860B2 (en) | 2018-04-10 | 2023-07-04 | Atea Pharmaceuticals, Inc. | Treatment of HCV infected patients with cirrhosis |
US11697666B2 (en) | 2021-04-16 | 2023-07-11 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
US11767337B2 (en) | 2020-02-18 | 2023-09-26 | Gilead Sciences, Inc. | Antiviral compounds |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104193791A (en) | 2002-06-28 | 2014-12-10 | 埃迪尼克斯医药公司 | Modified 2' and 3'-nucleoside produgs for treating flaviridae infections |
GB0317009D0 (en) | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
ATE478886T1 (en) | 2003-07-25 | 2010-09-15 | Idenix Pharmaceuticals Inc | PURINE NUCLEOSIDES FOR THE TREATMENT OF DISEASES CAUSED BY FLAVIVIDRAE, INCLUDING HEPATITIS C |
JP6069215B2 (en) | 2010-11-30 | 2017-02-01 | ギリアド ファーマセット エルエルシー | Compound |
CA2891125A1 (en) * | 2012-11-19 | 2014-05-22 | Merck Sharp & Dohme Corp. | 2 -alkynyl substituted nucleoside derivatives for treating viral diseases |
JP6728075B2 (en) * | 2014-06-24 | 2020-07-22 | ヤンセン バイオファーマ インク. | Substituted nucleosides, nucleotides and analogs thereof |
CN109748943A (en) * | 2017-11-03 | 2019-05-14 | 中国科学院上海药物研究所 | 2 '-C- methyl substituted nucleosides class compounds and its preparation and purposes |
CN111995649A (en) * | 2020-04-09 | 2020-11-27 | 瀚海新拓(杭州)生物医药有限公司 | Pteridinone nucleotide analogue and pharmaceutical composition, preparation method and medical application thereof |
WO2022008025A1 (en) * | 2020-07-05 | 2022-01-13 | Since & Technology Development Fund Authority | 2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto |
CN112979733B (en) * | 2021-04-25 | 2021-09-10 | 南京颐媛生物医学研究院有限公司 | Anti-hepatitis B virus compound and preparation method and application thereof |
Citations (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989002733A1 (en) | 1987-09-22 | 1989-04-06 | The Regents Of The University Of California | Liposomal nucleoside analogues for treating aids |
EP0350287A2 (en) | 1988-07-07 | 1990-01-10 | NeXstar Pharmaceuticals, Inc. | Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use |
WO1991016920A1 (en) | 1990-05-07 | 1991-11-14 | Vical, Inc. | Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs |
WO1991018914A1 (en) | 1990-05-29 | 1991-12-12 | Vical, Inc. | Synthesis of glycerol di- and triphosphate derivatives |
WO1991019721A1 (en) | 1990-06-13 | 1991-12-26 | Arnold Glazier | Phosphorous produgs |
US5149794A (en) | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
WO1993000910A1 (en) | 1991-07-12 | 1993-01-21 | Vical, Inc. | Antiviral liponucleosides: treatment of hepatitis b |
US5194654A (en) | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
US5256641A (en) | 1990-11-01 | 1993-10-26 | State Of Oregon | Covalent polar lipid-peptide conjugates for immunological targeting |
WO1994026273A1 (en) | 1993-05-12 | 1994-11-24 | Hostetler Karl Y | Acyclovir derivatives for topical use |
US5411947A (en) | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
US5463092A (en) | 1989-11-22 | 1995-10-31 | Vestar, Inc. | Lipid derivatives of phosphonacids for liposomal incorporation and method of use |
WO1996015132A1 (en) | 1994-11-15 | 1996-05-23 | The Regents Of The University Of California | Improved antiviral prodrugs |
US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
US5543389A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization | Covalent polar lipid-peptide conjugates for use in salves |
US5554728A (en) | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
WO1999045016A2 (en) | 1998-03-06 | 1999-09-10 | Metabasis Therapeutics, Inc. | Novel prodrugs for phosphorus-containing compounds |
WO2000052015A2 (en) | 1999-03-05 | 2000-09-08 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing prodrugs |
WO2001018013A1 (en) | 1999-09-08 | 2001-03-15 | Metabasis Therapeutics, Inc. | Prodrugs for liver specific drug delivery |
WO2001047935A2 (en) | 1999-12-22 | 2001-07-05 | Metabasis Therapeutics, Inc. | Novel bisamidate phosphonate prodrugs |
US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
Family Cites Families (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1695411A1 (en) * | 1966-05-02 | 1971-04-15 | Merck & Co Inc | Substituted purine nucleosides and processes for their preparation |
FR1521076A (en) * | 1966-05-02 | 1968-04-12 | Merck & Co Inc | Substituted purine nucleosides |
US3480613A (en) * | 1967-07-03 | 1969-11-25 | Merck & Co Inc | 2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof |
US3798209A (en) | 1971-06-01 | 1974-03-19 | Icn Pharmaceuticals | 1,2,4-triazole nucleosides |
USRE29835E (en) | 1971-06-01 | 1978-11-14 | Icn Pharmaceuticals | 1,2,4-Triazole nucleosides |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
FR2562543B1 (en) | 1984-04-10 | 1987-09-25 | Elf Aquitaine | NOVEL CYCLIC PHOSPHONITES, THEIR PREPARATION AND APPLICATIONS |
NL8403224A (en) | 1984-10-24 | 1986-05-16 | Oce Andeno Bv | DIOXAPHOSPHORINANS, THEIR PREPARATION AND THE USE FOR SPLITTING OF OPTICALLY ACTIVE COMPOUNDS. |
JP2706666B2 (en) * | 1987-07-31 | 1998-01-28 | 大鵬薬品工業株式会社 | 2'-deoxy-5-fluorouridine derivatives and salts thereof |
GB8719367D0 (en) | 1987-08-15 | 1987-09-23 | Wellcome Found | Therapeutic compounds |
EP0346108A3 (en) * | 1988-06-09 | 1991-04-24 | The Wellcome Foundation Limited | Anti-infective nucleosides |
US5705363A (en) | 1989-03-02 | 1998-01-06 | The Women's Research Institute | Recombinant production of human interferon τ polypeptides and nucleic acids |
JPH0368564A (en) | 1989-04-27 | 1991-03-25 | Tsumura & Co | Nucleic acid derivative |
JPH032193A (en) * | 1989-05-30 | 1991-01-08 | Ube Ind Ltd | 5-fluorouridine and 2'-deoxy-5-fluorouridine derivative |
JPH0383994A (en) * | 1989-08-28 | 1991-04-09 | Kuraray Co Ltd | 2'-deoxy-5-fluorouridine derivative, salt thereof, production thereof and antitumor agent comprising the same derivative as active ingredient |
US5026687A (en) | 1990-01-03 | 1991-06-25 | The United States Of America As Represented By The Department Of Health And Human Services | Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds |
DE69132332T2 (en) | 1990-04-06 | 2000-11-30 | Genelabs Tech Inc | HEPATITIS C-VIRUS-EPITOPE |
US5372808A (en) | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
US5595732A (en) | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
US5157027A (en) | 1991-05-13 | 1992-10-20 | E. R. Squibb & Sons, Inc. | Bisphosphonate squalene synthetase inhibitors and method |
TW224053B (en) | 1991-09-13 | 1994-05-21 | Paul B Chretien | |
JPH0597887A (en) * | 1991-10-02 | 1993-04-20 | Tanabe Seiyaku Co Ltd | New 2'-deoxy-5-fluorouridine derivative |
US5676942A (en) | 1992-02-10 | 1997-10-14 | Interferon Sciences, Inc. | Composition containing human alpha interferon species proteins and method for use thereof |
US5610054A (en) | 1992-05-14 | 1997-03-11 | Ribozyme Pharmaceuticals, Inc. | Enzymatic RNA molecule targeted against Hepatitis C virus |
GB9226729D0 (en) | 1992-12-22 | 1993-02-17 | Wellcome Found | Therapeutic combination |
JPH06211890A (en) * | 1993-01-12 | 1994-08-02 | Yamasa Shoyu Co Ltd | 2'-deoxy-2'@(3754/24)s)-substituted alkylcytidine derivative |
JPH06228186A (en) * | 1993-01-29 | 1994-08-16 | Yamasa Shoyu Co Ltd | 2'-deoxy-@(3754/24)2's)-alkylpyrimidine nucleoside derivative |
US5496546A (en) | 1993-02-24 | 1996-03-05 | Jui H. Wang | Compositions and methods of application of reactive antiviral polyadenylic acid derivatives |
EP0773029A4 (en) | 1993-07-19 | 1997-09-03 | Tokyo Tanabe Co | Hepatitis c virus proliferation inhibitor |
NZ276943A (en) | 1993-11-10 | 1998-02-26 | Schering Corp Substituted For | Alpha-interferon conjugated to a non-antigenic polymer (preferably a polyalkylene oxide) and its preparation |
US5951974A (en) | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
DE4447588C2 (en) | 1994-05-03 | 1997-11-20 | Omer Osama Dr Dr Med | Treatment of herpes and hepatitis virus infections and bronchitis |
DE4432623A1 (en) | 1994-09-14 | 1996-03-21 | Huels Chemische Werke Ag | Process for bleaching aqueous surfactant solutions |
US5738846A (en) | 1994-11-10 | 1998-04-14 | Enzon, Inc. | Interferon polymer conjugates and process for preparing the same |
JP3786447B2 (en) | 1995-03-31 | 2006-06-14 | エーザイ株式会社 | Preventive and therapeutic agent for hepatitis C |
GB9606264D0 (en) * | 1995-07-13 | 1996-05-29 | Hoffmann La Roche | Pyrimidine nucleoside derivatives |
DE69635864T2 (en) | 1995-09-27 | 2006-10-26 | Emory University | RECOMBINANT RNA REPLICASE OF HEPATITIS C VIRUS |
US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
US5980884A (en) | 1996-02-05 | 1999-11-09 | Amgen, Inc. | Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon |
JP2000506010A (en) | 1996-02-29 | 2000-05-23 | イミューソル インコーポレイテッド | Hepatitis C virus ribozyme |
US5633388A (en) | 1996-03-29 | 1997-05-27 | Viropharma Incorporated | Compounds, compositions and methods for treatment of hepatitis C |
US5830905A (en) | 1996-03-29 | 1998-11-03 | Viropharma Incorporated | Compounds, compositions and methods for treatment of hepatitis C |
US5990276A (en) | 1996-05-10 | 1999-11-23 | Schering Corporation | Synthetic inhibitors of hepatitis C virus NS3 protease |
GB9609932D0 (en) | 1996-05-13 | 1996-07-17 | Hoffmann La Roche | Use of IL-12 and IFN alpha for the treatment of infectious diseases |
US5891874A (en) | 1996-06-05 | 1999-04-06 | Eli Lilly And Company | Anti-viral compound |
US5837257A (en) | 1996-07-09 | 1998-11-17 | Sage R&D | Use of plant extracts for treatment of HIV, HCV and HBV infections |
JP3927630B2 (en) | 1996-09-27 | 2007-06-13 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Preventive and therapeutic agents for viral infections |
US5922757A (en) | 1996-09-30 | 1999-07-13 | The Regents Of The University Of California | Treatment and prevention of hepatic disorders |
CA2266889A1 (en) * | 1996-10-16 | 1998-04-23 | Guangyi Wang | Purine l-nucleosides, analogs and uses thereof |
NZ335276A (en) | 1996-10-18 | 2000-09-29 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease |
AU735438B2 (en) * | 1996-11-12 | 2001-07-05 | Medivir Ab | Nucleosides |
GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
IL119833A (en) | 1996-12-15 | 2001-01-11 | Lavie David | Hypericum perforatum extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis |
US6004933A (en) | 1997-04-25 | 1999-12-21 | Cortech Inc. | Cysteine protease inhibitors |
EP1009732B1 (en) | 1997-06-30 | 2003-05-21 | MERZ + CO. GmbH & Co. | 1-amino-alkylcyclohexane nmda receptor antagonists |
ES2234144T3 (en) | 1997-08-11 | 2005-06-16 | Boehringer Ingelheim (Canada) Ltd. | ANALOGS OF INHIBITING PEPTIDES OF HEPATITIS C. |
DE69810822T2 (en) | 1997-09-21 | 2003-11-20 | Schering Corp | Combination therapy for the removal of detectable HCV-RNA in patients with chronic hepatitis C infection |
US5981709A (en) | 1997-12-19 | 1999-11-09 | Enzon, Inc. | α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same |
EP2390257A1 (en) | 1998-02-25 | 2011-11-30 | Emory University | 2'-fluoronucleosides |
GB9806815D0 (en) | 1998-03-30 | 1998-05-27 | Hoffmann La Roche | Amino acid derivatives |
ES2172288T3 (en) | 1998-05-15 | 2002-09-16 | Schering Corp | COMBINATION THERAPY THAT UNDERSTANDS RIBAVIRINA AND INTERFERED ALPHA IN PATIENTS WHO HAVE NOT BEEN SUBJECTED TO ANTIVIRAL TREATMENT AND HAVE CHRONIC HEPATITIS C INFECTION. |
SI1087778T1 (en) | 1998-06-08 | 2006-02-28 | Hoffmann La Roche | Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c |
DK1431304T3 (en) | 1998-08-10 | 2015-03-02 | Novartis Ag | Beta - L-2'-deoxynucleosides for the treatment of hepatitis B |
US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
FR2784892B1 (en) | 1998-10-23 | 2001-04-06 | Smith & Nephew Kinetec Sa | FOLDABLE PASSIVE MOBILIZATION BRACKET FOR LOWER MEMBER |
CA2354536A1 (en) | 1998-12-18 | 2000-06-29 | Schering Corporation | Ribavirin-pegylated interferon alfa induction hcv combination therapy |
US6566365B1 (en) | 1999-11-04 | 2003-05-20 | Biochem Pharma Inc. | Method for the treatment of Flaviviridea viral infection using nucleoside analogues |
WO2001060315A2 (en) * | 2000-02-18 | 2001-08-23 | Shire Biochem Inc. | Method for the treatment or prevention of flavivirus infections using nucleoside analogues |
KR20100003313A (en) | 2000-04-13 | 2010-01-07 | 파마셋 인코포레이티드 | 3'- or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections |
WO2001081359A1 (en) | 2000-04-20 | 2001-11-01 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection |
MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
YU92202A (en) * | 2000-05-26 | 2006-01-16 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses |
ES2227203T3 (en) * | 2000-05-26 | 2005-04-01 | Idenix (Cayman) Limited | METHODS TO TREAT INFECTION WITH THE DELTA HEPATITIS VIRUS WITH BETA-1-2'-DEOXINUCLEOSIDS. |
MY141594A (en) | 2000-06-15 | 2010-05-14 | Novirio Pharmaceuticals Ltd | 3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES |
AR034127A1 (en) | 2000-07-21 | 2004-02-04 | Schering Corp | IMIDAZOLIDINONES AS INHIBITORS OF NS3-SERINA PROTEASA OF THE HEPATITIS C VIRUS, PHARMACEUTICAL COMPOSITION, A METHOD FOR THEIR PREPARATION, AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT |
HUP0303358A3 (en) | 2000-07-21 | 2005-10-28 | Schering Corp | Novel peptides as ns3-serine protease inhibitors of hepatitis c virus and pharmaceutical compositions containing them |
AR029851A1 (en) | 2000-07-21 | 2003-07-16 | Dendreon Corp | NEW PEPTIDES AS INHIBITORS OF NS3-SERINA PROTEASA DEL VIRUS DE HEPATITIS C |
WO2002008251A2 (en) | 2000-07-21 | 2002-01-31 | Corvas International, Inc. | Peptides as ns3-serine protease inhibitors of hepatitis c virus |
US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
SV2003000617A (en) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | INHIBITORS OF PROTEASA PEPTIDOMIMETICA REF. X-14912M |
AU2002213343A1 (en) | 2000-10-18 | 2002-04-29 | Schering Corporation | Ribavirin-pegylated interferon alfa HCV combination therapy |
KR101005299B1 (en) | 2000-10-18 | 2011-01-04 | 파마셋 인코포레이티드 | Modified nucleosides for treatment of viral infections and abnormal cellular proliferation |
ES2263687T3 (en) | 2000-11-20 | 2006-12-16 | Bristol-Myers Squibb Company | TRIPEPTIDIC INHIBITORS OF HEPATITIS C. |
EP1343807B1 (en) | 2000-12-12 | 2009-04-29 | Schering Corporation | Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus |
AU2002230764A1 (en) | 2000-12-13 | 2002-06-24 | Bristol-Myers Squibb Pharma Company | Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors |
WO2002048116A2 (en) | 2000-12-13 | 2002-06-20 | Bristol-Myers Squibb Pharma Company | Inhibitors of hepatitis c virus ns3 protease |
EP1366055A2 (en) | 2000-12-15 | 2003-12-03 | Pharmasset Limited | Antiviral agents for treatment of flaviviridae infections |
CZ20032005A3 (en) | 2001-01-22 | 2004-04-14 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
WO2003024461A1 (en) | 2001-09-20 | 2003-03-27 | Schering Corporation | Hcv combination therapy |
WO2003068244A1 (en) * | 2002-02-13 | 2003-08-21 | Merck & Co., Inc. | Methods of inhibiting orthopoxvirus replication with nucleoside compounds |
CN1653077A (en) * | 2002-05-06 | 2005-08-10 | 健亚生物科技公司 | Nucleoside derivatives for treating hepatitis C virus infection |
AU2003251524A1 (en) * | 2002-06-17 | 2003-12-31 | Isis Pharmaceuticals, Inc. | Carbocyclic nucleoside analogs as RNA-antivirals |
WO2004003000A2 (en) * | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | 1’-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections |
CN104193791A (en) * | 2002-06-28 | 2014-12-10 | 埃迪尼克斯医药公司 | Modified 2' and 3'-nucleoside produgs for treating flaviridae infections |
EP3521297B1 (en) | 2003-05-30 | 2021-12-22 | Gilead Pharmasset LLC | Modified fluorinated nucleoside analogues |
-
2003
- 2003-06-27 CN CN201410321326.4A patent/CN104193791A/en active Pending
- 2003-06-27 EP EP20100183144 patent/EP2332952B1/en not_active Revoked
- 2003-06-27 KR KR1020047021286A patent/KR20050048544A/en not_active Application Discontinuation
- 2003-06-27 PT PT37617446T patent/PT1523489E/en unknown
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- 2003-06-27 CN CN2013100374594A patent/CN103275159A/en active Pending
- 2003-06-27 TW TW092117546A patent/TW200500375A/en unknown
- 2003-06-27 RS YUP-1140/04A patent/RS114004A/en unknown
- 2003-06-27 DK DK03761744.6T patent/DK1523489T3/en active
- 2003-06-27 ES ES03761744.6T patent/ES2469569T3/en not_active Expired - Lifetime
- 2003-06-27 AP AP2005003212A patent/AP2005003212A0/en unknown
- 2003-06-27 WO PCT/IB2003/003246 patent/WO2004002999A2/en active Search and Examination
- 2003-06-27 BR BRPI0312271-9A patent/BR0312271A/en not_active IP Right Cessation
- 2003-06-27 DE DE14169110.5T patent/DE14169110T1/en active Pending
- 2003-06-27 CN CNB038206900A patent/CN100348607C/en not_active Expired - Fee Related
- 2003-06-27 MX MXPA04012709A patent/MXPA04012709A/en active IP Right Grant
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- 2003-06-27 CN CN2013100366386A patent/CN103319554A/en active Pending
- 2003-06-27 CN CN201410321246.9A patent/CN104163841B/en not_active Expired - Lifetime
- 2003-06-27 CA CA2490191A patent/CA2490191C/en not_active Expired - Lifetime
- 2003-06-27 PL PL03374831A patent/PL374831A1/en unknown
- 2003-06-27 EP EP03761744.6A patent/EP1523489B1/en not_active Revoked
- 2003-06-27 CN CN2011102533933A patent/CN102424698A/en active Pending
- 2003-06-27 BR BRPI0312286-7A patent/BR0312286A/en not_active Application Discontinuation
- 2003-06-27 TW TW092117542A patent/TW200500374A/en unknown
- 2003-06-27 MY MYPI20032435A patent/MY140819A/en unknown
- 2003-06-27 AU AU2003247084A patent/AU2003247084B9/en not_active Expired
- 2003-06-27 JP JP2004517158A patent/JP2005533817A/en active Pending
- 2003-06-30 AR ARP030102363A patent/AR043101A1/en not_active Application Discontinuation
- 2003-06-30 AR ARP030102365A patent/AR043298A1/en not_active Application Discontinuation
- 2003-06-30 PE PE2003000661A patent/PE20040636A1/en not_active Application Discontinuation
- 2003-06-30 UY UY27874A patent/UY27874A1/en not_active Application Discontinuation
- 2003-06-30 PE PE2003000659A patent/PE20040634A1/en not_active Application Discontinuation
- 2003-06-30 UY UY27876A patent/UY27876A1/en not_active Application Discontinuation
- 2003-06-30 PE PE2003000660A patent/PE20040635A1/en not_active Application Discontinuation
- 2003-06-30 UY UY27875A patent/UY27875A1/en not_active Application Discontinuation
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- 2004-12-21 IL IL16589304A patent/IL165893A0/en unknown
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- 2005-01-26 MA MA28072A patent/MA27375A1/en unknown
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-
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- 2017-12-12 JP JP2017237804A patent/JP2018076342A/en active Pending
Patent Citations (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989002733A1 (en) | 1987-09-22 | 1989-04-06 | The Regents Of The University Of California | Liposomal nucleoside analogues for treating aids |
EP0350287A2 (en) | 1988-07-07 | 1990-01-10 | NeXstar Pharmaceuticals, Inc. | Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use |
WO1990000555A1 (en) | 1988-07-07 | 1990-01-25 | Vical, Inc. | Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use |
US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
US5411947A (en) | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
US5463092A (en) | 1989-11-22 | 1995-10-31 | Vestar, Inc. | Lipid derivatives of phosphonacids for liposomal incorporation and method of use |
US5194654A (en) | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
WO1991016920A1 (en) | 1990-05-07 | 1991-11-14 | Vical, Inc. | Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs |
WO1991018914A1 (en) | 1990-05-29 | 1991-12-12 | Vical, Inc. | Synthesis of glycerol di- and triphosphate derivatives |
WO1991019721A1 (en) | 1990-06-13 | 1991-12-26 | Arnold Glazier | Phosphorous produgs |
US5149794A (en) | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
US5256641A (en) | 1990-11-01 | 1993-10-26 | State Of Oregon | Covalent polar lipid-peptide conjugates for immunological targeting |
US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
US5543391A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
US5543389A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization | Covalent polar lipid-peptide conjugates for use in salves |
WO1993000910A1 (en) | 1991-07-12 | 1993-01-21 | Vical, Inc. | Antiviral liponucleosides: treatment of hepatitis b |
US5554728A (en) | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
WO1994026273A1 (en) | 1993-05-12 | 1994-11-24 | Hostetler Karl Y | Acyclovir derivatives for topical use |
WO1996015132A1 (en) | 1994-11-15 | 1996-05-23 | The Regents Of The University Of California | Improved antiviral prodrugs |
WO1999045016A2 (en) | 1998-03-06 | 1999-09-10 | Metabasis Therapeutics, Inc. | Novel prodrugs for phosphorus-containing compounds |
US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
WO2000052015A2 (en) | 1999-03-05 | 2000-09-08 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing prodrugs |
WO2001018013A1 (en) | 1999-09-08 | 2001-03-15 | Metabasis Therapeutics, Inc. | Prodrugs for liver specific drug delivery |
WO2001047935A2 (en) | 1999-12-22 | 2001-07-05 | Metabasis Therapeutics, Inc. | Novel bisamidate phosphonate prodrugs |
Non-Patent Citations (20)
Title |
---|
BAGINSKI, S. G., PEVEAR, D. C., SEIPEL, M., SUN, S. C. C., BENETATOS, C. A., CHUNDURU, S. K., RICE, C. M., M. S. COLLETT: "Mechanism of action of a pestivirus antiviral compound", PNAS USA, vol. 97, no. 14, 2000, pages 7981 - 7986 |
DELAMBERT ET AL., J. MED. CHEM., vol. 37, 1994, pages 498 |
FIELDS, B. N., KNIPE, D. M., AND HOWLEY, P. M.,: "Fields Virology", 1996, LIPPINCOTT-RAVEN PUBLISHERS |
GREENE ET AL.: "Protective Groups in Organic Synthesis, Second Edition,", 1991, JOHN WILEY AND SONS |
HOSETLER, K.Y., L.M. ST?HMILLER, H.B. LENTING, H. VAN DEN BOSCH, D.D. RICHMAN: "Synthesis and antiretroviral activity of phospholipid analogs of azidothymine and other antiviral nucleosides", J. BIOL. CHEM., vol. 265, 1990, pages 61127 |
HOSTELLER, K.Y., D.D. RICHMAN, D.A. CARSON, L.M. STUHMILLER, G.M. T. VAN WIJK, H. VAN DEN BOSCH.: "Greatly enhanced inhibition of human immunodeficiency virus type 1 replication in CEM and HT4-6C cells by 3'-deoxythymine diphosphate dimyristoylglycerol, a lipid prodrug of 3,-deoxythymine", ANTIMICROB. AGENTS CHEMOTHER., vol. 36, 1992, pages 2025 - 2029 |
HUNSTON ET AL., J. MED. CHEM., vol. 27, 1984, pages 440 - 444 |
J AM. CHEM. SOC., vol. 121, no. 24, 1999, pages 5661 - 5664 |
J MED. CHEM., vol. 34, pages 1408 - 1414 |
J. AM. CHEM. SOC., vol. 121, no. 24, 1999, pages 5661 - 5664 |
J. FARKAS, COLLECT. CZECH. CHEM. COMMUN., vol. 31, 1966, pages 1535 |
J. FARKAS, F. SORM: "Nucleic acid components and their analogues. XCIV. Synthesis of 6-amino-9-(1-deoxy-?-D-psicofuranosyl)purine", COLLECT. CZECH. CHEM. COMMUN., vol. 32, 1967, pages 2663 - 2667, XP001016337 |
KHAMNEI, TORRENCE, J. MED. CHEM., vol. 39, 1996, pages 4109 - 4115 |
MEIER ET AL., BIOORG. MED. CHEM. |
MEIER ET AL., J. MED. CHEM., vol. 22, 1979, pages 811 - 815 |
MITCHELL ET AL., J. CHEM. SOC. PERKIN TRANS., 1992, pages 12345 |
R. JONES, N. BISCHOFERGER, ANTIVIRAL RESEARCH, vol. 27, 1995, pages 1 - 17 |
STARRETT ET AL., J. MED. CHEM., vol. 37, 1994, pages 1857 - 1864 |
SYNTHETIC COMMUNICATIONS, vol. 8, no. 5, 1978, pages 327 - 333 |
TOWNSEND: "Chemistry of Nucleosides and Nucleotides", 1994, PLENUM PRESS |
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US7151092B2 (en) | 2002-10-31 | 2006-12-19 | Metabasis Therapeutics, Inc. | Cytarabine monophosphate prodrugs |
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US7553826B2 (en) | 2002-10-31 | 2009-06-30 | Metabasis Therapeutics, Inc. | Cytarabine monophosphate prodrugs |
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US7824851B2 (en) | 2002-11-15 | 2010-11-02 | Idenix Pharmaceuticals, Inc. | 2′-branched nucleosides and Flaviviridae mutation |
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WO2005123087A2 (en) | 2004-06-15 | 2005-12-29 | Merck & Co., Inc. | C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase |
US7534767B2 (en) | 2004-06-15 | 2009-05-19 | Merck & Co., Inc. | C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase |
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US7935681B2 (en) | 2006-10-10 | 2011-05-03 | Medivir Ab | Antiviral nucleosides |
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US8227431B2 (en) | 2008-03-17 | 2012-07-24 | Hetero Drugs Limited | Nucleoside derivatives |
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US9096603B2 (en) | 2008-04-02 | 2015-08-04 | Boehringer Ingelheim International Gmbh | 1-heterocyclyl-1,5-dihydro-pyrazolo[3,4-D] pyrimidin-4-one derivatives and their use as PDE9A modulators |
EP2268288A4 (en) * | 2008-04-15 | 2012-05-30 | Rfs Pharma Llc | Nucleoside derivatives for treatment of caliciviridae infections, including norovirus infections |
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US8415321B2 (en) | 2008-04-15 | 2013-04-09 | Raymond F. Schinazi | Nucleoside derivatives for treatment of Caliciviridae infections, including Norovirus infections |
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WO2009129120A2 (en) | 2008-04-15 | 2009-10-22 | Rfs Pharma, Llc | Nucleoside derivatives for treatment of caliciviridae infections, including norovirus infections |
US8461107B2 (en) | 2008-04-28 | 2013-06-11 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
EP2141172A1 (en) | 2008-07-01 | 2010-01-06 | Ortho Biotech Products L.P. | Cyclopropyl polymerase inhibitors |
WO2010000459A1 (en) * | 2008-07-01 | 2010-01-07 | Centocor Ortho Biotech Products L.P. | Cyclopropyl polymerase inhibitors |
EA022754B1 (en) * | 2008-07-01 | 2016-02-29 | СЕНТОКОР ОРТО БАЙОТЕК ПРОДАКТС Эл.Пи. | Cyclopropyl polymerase inhibitors |
CN105693794A (en) * | 2008-07-01 | 2016-06-22 | 杨森产品有限公司 | Cyclopropyl polymerase inhibitors |
US20110092460A1 (en) * | 2008-07-01 | 2011-04-21 | Centocor Ortho Biotech Products L.P. | Cyclopropyl polymerase inhibitors |
CN102083845B (en) * | 2008-07-01 | 2016-09-14 | 森托科尔奥索生物科技产品股份有限公司 | Cyclopropyl polymerase inhibitors |
US8431588B2 (en) | 2008-07-01 | 2013-04-30 | Janssen Products, Lp | Cyclopropyl polymerase inhibitors |
AU2009266004B2 (en) * | 2008-07-01 | 2014-01-30 | Centocor Ortho Biotech Products L.P. | Cyclopropyl polymerase inhibitors |
EP2476690A1 (en) | 2008-07-02 | 2012-07-18 | IDENIX Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
EP2540349A1 (en) | 2008-07-22 | 2013-01-02 | Merck Sharp & Dohme Corp. | Pharmaceutical compositions comprising a macrocyclic quinoxaline compound which is an HCV NS3 protease inhibitor |
EP2540350A1 (en) | 2008-07-22 | 2013-01-02 | Merck Sharp & Dohme Corp. | Combinations of a macrocyclic quinoxaline compound which is an HCV NS3 protease inhibitors with other HCV agents |
US8080654B2 (en) | 2008-07-22 | 2011-12-20 | Insituto di Ricerche di Biologia Molecolare P. Angeletti SpA | Macrocyclic quinoxaline compounds as HCV NS3 protease inhibitors |
US7973040B2 (en) | 2008-07-22 | 2011-07-05 | Merck Sharp & Dohme Corp. | Macrocyclic quinoxaline compounds as HCV NS3 protease inhibitors |
US9079905B2 (en) | 2008-09-08 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Compounds for the treatment of CNS disorders |
US8629275B2 (en) | 2008-09-08 | 2014-01-14 | Merck Sharp & Dohme Corp. | AHCY hydrolase inhibitors for treatment of hyper homocysteinemia |
CN102256991A (en) * | 2008-12-08 | 2011-11-23 | 森托科尔奥索生物科技产品股份有限公司 | Uracyl cyclopropyl nucleotides |
AU2009326125B2 (en) * | 2008-12-08 | 2015-03-12 | Centocor Ortho Biotech Products L.P. | Uracyl cyclopropyl nucleotides |
EA020244B1 (en) * | 2008-12-08 | 2014-09-30 | СЕНТОКОР ОРТО БАЙОТЕК ПРОДАКТС Эл.Пи. | Uracyl cyclopropyl nucleotides |
US8399429B2 (en) | 2008-12-08 | 2013-03-19 | Janssen Products, Lp | Uracyl cyclopropyl nucleotides |
CN102256991B (en) * | 2008-12-08 | 2015-08-12 | 森托科尔奥索生物科技产品股份有限公司 | Uracyl cyclopropyl nucleotides |
WO2010066699A1 (en) * | 2008-12-08 | 2010-06-17 | Centocor Ortho Biotech Products L.P. | Uracyl cyclopropyl nucleotides |
US8957045B2 (en) | 2008-12-23 | 2015-02-17 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US8551973B2 (en) | 2008-12-23 | 2013-10-08 | Gilead Pharmasset Llc | Nucleoside analogs |
US8716262B2 (en) | 2008-12-23 | 2014-05-06 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US8716263B2 (en) | 2008-12-23 | 2014-05-06 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
WO2010082050A1 (en) | 2009-01-16 | 2010-07-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections |
WO2010084115A2 (en) | 2009-01-20 | 2010-07-29 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Antiviral agents |
WO2010101967A2 (en) | 2009-03-04 | 2010-09-10 | Idenix Pharmaceuticals, Inc. | Phosphothiophene and phosphothiazole hcv polymerase inhibitors |
US8623901B2 (en) | 2009-03-31 | 2014-01-07 | Boehringer Ingelheim International Gmbh | Compounds for the treatment of CNS disorders |
US9102679B2 (en) | 2009-03-31 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Compounds for the treatment of CNS disorders |
US8735569B2 (en) | 2009-05-20 | 2014-05-27 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US8629263B2 (en) | 2009-05-20 | 2014-01-14 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US9284342B2 (en) | 2009-05-20 | 2016-03-15 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US8642756B2 (en) | 2009-05-20 | 2014-02-04 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US8633309B2 (en) | 2009-05-20 | 2014-01-21 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US9206217B2 (en) | 2009-05-20 | 2015-12-08 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US9637512B2 (en) | 2009-05-20 | 2017-05-02 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US8093275B2 (en) | 2009-06-22 | 2012-01-10 | Roche Palo Alto Llc | Oxazolone and pyrrolidinone-substituted pryidine amides as P2X3 and P2X2/3 antagonists |
US8283383B2 (en) | 2009-06-22 | 2012-10-09 | Roche Palo Alto Llc | Biphenyl amides as P2X3 and P2X2/3 antagonists |
US8476457B2 (en) | 2009-06-22 | 2013-07-02 | Roche Palo Alto Llc | Indole, indazole and benzimidazole arylamides as P2X3 and P2X2/3 antagonists |
WO2011014487A1 (en) | 2009-07-30 | 2011-02-03 | Merck Sharp & Dohme Corp. | Hepatitis c virus ns3 protease inhibitors |
US8828930B2 (en) | 2009-07-30 | 2014-09-09 | Merck Sharp & Dohme Corp. | Hepatitis C virus NS3 protease inhibitors |
WO2011017389A1 (en) | 2009-08-05 | 2011-02-10 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv |
WO2011058084A1 (en) | 2009-11-14 | 2011-05-19 | F. Hoffmann-La Roche Ag | Biomarkers for predicting rapid response to hcv treatment |
WO2011063076A1 (en) | 2009-11-19 | 2011-05-26 | Itherx Pharmaceuticals, Inc. | Methods of treating hepatitis c virus with oxoacetamide compounds |
WO2011067195A1 (en) | 2009-12-02 | 2011-06-09 | F. Hoffmann-La Roche Ag | Biomarkers for predicting sustained response to hcv treatment |
WO2011075615A1 (en) | 2009-12-18 | 2011-06-23 | Idenix Pharmaceuticals, Inc. | 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors |
US8859756B2 (en) | 2010-03-31 | 2014-10-14 | Gilead Pharmasset Llc | Stereoselective synthesis of phosphorus containing actives |
WO2011123586A1 (en) | 2010-04-01 | 2011-10-06 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
US8680071B2 (en) | 2010-04-01 | 2014-03-25 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
US9328120B2 (en) | 2010-08-12 | 2016-05-03 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
US8912201B2 (en) | 2010-08-12 | 2014-12-16 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
US9346848B2 (en) | 2010-09-22 | 2016-05-24 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
US8877731B2 (en) | 2010-09-22 | 2014-11-04 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
WO2012080050A1 (en) | 2010-12-14 | 2012-06-21 | F. Hoffmann-La Roche Ag | Solid forms of a phenoxybenzenesulfonyl compound |
WO2012109398A1 (en) | 2011-02-10 | 2012-08-16 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating hcv infections |
US8809345B2 (en) | 2011-02-15 | 2014-08-19 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
WO2012154321A1 (en) | 2011-03-31 | 2012-11-15 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
WO2012135581A1 (en) | 2011-03-31 | 2012-10-04 | Idenix Pharmaceuticals, Inc. | Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor |
WO2012142523A2 (en) | 2011-04-13 | 2012-10-18 | Gilead Sciences, Inc. | 1'-substituted pyrimidine n-nucleoside analogs for antiviral treatment |
WO2013039855A1 (en) | 2011-09-12 | 2013-03-21 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
US8951985B2 (en) | 2011-09-12 | 2015-02-10 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
WO2013039920A1 (en) | 2011-09-12 | 2013-03-21 | Idenix Pharmaceuticals, Inc. | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
US10456414B2 (en) | 2011-09-16 | 2019-10-29 | Gilead Pharmasset Llc | Methods for treating HCV |
WO2013056046A1 (en) | 2011-10-14 | 2013-04-18 | Idenix Pharmaceuticals, Inc. | Substituted 3',5'-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
US9328138B2 (en) | 2011-11-15 | 2016-05-03 | Msd Italia S.R.L. | HCV NS3 protease inhibitors |
WO2013074386A2 (en) | 2011-11-15 | 2013-05-23 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
EP3750544A2 (en) | 2011-11-30 | 2020-12-16 | Emory University | Jak inhibitors for use in the prevention or treatment of viral infection |
US9073960B2 (en) | 2011-12-22 | 2015-07-07 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US11021509B2 (en) | 2011-12-22 | 2021-06-01 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US10464965B2 (en) | 2011-12-22 | 2019-11-05 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
WO2013133927A1 (en) | 2012-02-13 | 2013-09-12 | Idenix Pharmaceuticals, Inc. | Pharmaceutical compositions of 2'-c-methyl-guanosine, 5'-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl n-(phenylmethyl)phosphoramidate] |
US10485815B2 (en) | 2012-03-21 | 2019-11-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
WO2013177219A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | D-amino acid compounds for liver disease |
WO2013177195A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphate prodrugs for hcv infection |
US9845336B2 (en) | 2012-05-25 | 2017-12-19 | Janssen Sciences Ireland Uc | Uracyl spirooxetane nucleosides |
US10774106B2 (en) | 2012-05-25 | 2020-09-15 | Janssen Sciences Ireland Unlimited Company | Uracyl spirooxetane nucleosides |
US10301347B2 (en) | 2012-05-25 | 2019-05-28 | Janssen Sciences Ireland Unlimited Company | Uracyl spirooxetane nucleosides |
US10544184B2 (en) | 2012-05-25 | 2020-01-28 | Janssen Sciences Ireland Unlimited Company | Uracyl spirooxetane nucleosides |
US10040814B2 (en) | 2012-05-25 | 2018-08-07 | Janssen Sciences Ireland Uc | Uracyl spirooxetane nucleosides |
WO2014058801A1 (en) | 2012-10-08 | 2014-04-17 | Idenix Pharmaceuticals, Inc. | 2'-chloro nucleoside analogs for hcv infection |
WO2014063019A1 (en) | 2012-10-19 | 2014-04-24 | Idenix Pharmaceuticals, Inc. | Dinucleotide compounds for hcv infection |
WO2014066239A1 (en) | 2012-10-22 | 2014-05-01 | Idenix Pharmaceuticals, Inc. | 2',4'-bridged nucleosides for hcv infection |
WO2014078427A1 (en) | 2012-11-14 | 2014-05-22 | Idenix Pharmaceuticals, Inc. | D-alanine ester of rp-nucleoside analog |
WO2014078436A1 (en) | 2012-11-14 | 2014-05-22 | Idenix Pharmaceuticals, Inc. | D-alanine ester of sp-nucleoside analog |
WO2014099941A1 (en) | 2012-12-19 | 2014-06-26 | Idenix Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
US10683320B2 (en) | 2012-12-21 | 2020-06-16 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US10144755B2 (en) | 2012-12-21 | 2018-12-04 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US10487104B2 (en) | 2012-12-21 | 2019-11-26 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US9243022B2 (en) | 2012-12-21 | 2016-01-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US10793591B2 (en) | 2012-12-21 | 2020-10-06 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US10112966B2 (en) | 2012-12-21 | 2018-10-30 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US9249174B2 (en) | 2012-12-21 | 2016-02-02 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US11485753B2 (en) | 2012-12-21 | 2022-11-01 | Janssen Pharmaceutica Nv | Substituted nucleosides, nucleotides and analogs thereof |
US10039779B2 (en) | 2013-01-31 | 2018-08-07 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
WO2014123795A2 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
WO2014123794A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
WO2014137926A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | 3'-deoxy nucleosides for the treatment of hcv |
WO2014137930A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | Thiophosphate nucleosides for the treatment of hcv |
WO2014148949A1 (en) | 2013-03-22 | 2014-09-25 | Асави, Ллс | Alkyl 2-{[(2r,3s,5r)-5-(4-amino-2-oxo-2н-pyrimidin-1-yl)-3-hydroxy- tetrahydro-furan-2-yl-methoxy]-phenoxy-phosphoryl-amino}-propionates, nucleoside inhibitors of hcv ns5b rna-polymerase, and methods for producing and use thereof |
WO2014165542A1 (en) | 2013-04-01 | 2014-10-09 | Idenix Pharmaceuticals, Inc. | 2',4'-fluoro nucleosides for the treatment of hcv |
US9447132B2 (en) | 2013-04-12 | 2016-09-20 | Achillion Pharmaceuticals, Inc. | Highly active nucleoside derivative for the treatment of HCV |
WO2014197578A1 (en) | 2013-06-05 | 2014-12-11 | Idenix Pharmaceuticals, Inc. | 1',4'-thio nucleosides for the treatment of hcv |
WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
US11707479B2 (en) | 2013-08-27 | 2023-07-25 | Gilead Sciences, Inc. | Combination formulation of two antiviral compounds |
US11116783B2 (en) | 2013-08-27 | 2021-09-14 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
US11857560B2 (en) | 2013-09-11 | 2024-01-02 | Emory University | Pharmaceutical compositions comprising substituted nucleotides and nucleosides for treating viral infections |
US11166973B2 (en) | 2013-09-11 | 2021-11-09 | Emory University | Substituted nucleotides and nucleosides for treating viral infections |
WO2015042375A1 (en) | 2013-09-20 | 2015-03-26 | Idenix Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
US9862743B2 (en) | 2013-10-11 | 2018-01-09 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US10370401B2 (en) | 2013-10-11 | 2019-08-06 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
WO2015054465A1 (en) * | 2013-10-11 | 2015-04-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
WO2015061683A1 (en) | 2013-10-25 | 2015-04-30 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate and d-alanine thiophosphoramidate pronucleotides of nucleoside compounds useful for the treatment of hcv |
WO2015066370A1 (en) | 2013-11-01 | 2015-05-07 | Idenix Pharmaceuticals, Inc. | D-alanine phosphoramidate pronucleotides of 2'-methyl 2'-fluoro guanosine nucleoside compounds for the treatment of hcv |
WO2015081297A1 (en) | 2013-11-27 | 2015-06-04 | Idenix Pharmaceuticals, Inc. | 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection |
US10683321B2 (en) | 2013-12-18 | 2020-06-16 | Idenix Pharmaceuticals Llc | 4′-or nucleosides for the treatment of HCV |
WO2015095419A1 (en) | 2013-12-18 | 2015-06-25 | Idenix Pharmaceuticals, Inc. | 4'-or nucleosides for the treatment of hcv |
US11278559B2 (en) | 2014-02-13 | 2022-03-22 | Ligand Pharmaceuticals Incorporated | Prodrug compounds and their uses |
US10449210B2 (en) | 2014-02-13 | 2019-10-22 | Ligand Pharmaceuticals Inc. | Prodrug compounds and their uses |
WO2015134780A1 (en) | 2014-03-05 | 2015-09-11 | Idenix Pharmaceuticals, Inc. | Solid prodrug forms of 2'-chloro-2'-methyl uridine for hcv |
WO2015134561A1 (en) | 2014-03-05 | 2015-09-11 | Idenix Pharmaceuticals, Inc. | Pharmaceutical compositions comprising a 5,5-fused heteroarylene flaviviridae inhibitor and their use for treating or preventing flaviviridae infection |
WO2015134560A1 (en) | 2014-03-05 | 2015-09-11 | Idenix Pharmaceuticals, Inc. | Solid forms of a flaviviridae virus inhibitor compound and salts thereof |
WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
CN103992360A (en) * | 2014-04-21 | 2014-08-20 | 中美华世通生物医药科技(武汉)有限公司 | Reduction method suitable for industrialized production |
US9994600B2 (en) | 2014-07-02 | 2018-06-12 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses therof |
US10150788B2 (en) | 2014-07-02 | 2018-12-11 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses thereof |
US10005811B2 (en) | 2015-03-06 | 2018-06-26 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-α-fluoro-2′β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment |
US10875885B2 (en) | 2015-03-06 | 2020-12-29 | Atea Pharmaceuticals, Inc. | β-d-2′-deoxy-2′-α-fluoro-2′-β-c-substituted-2-modified-n6-substituted purine nucleotides for HCV treatment |
US10239911B2 (en) | 2015-03-06 | 2019-03-26 | Atea Pharmaceuticals, Inc. | Beta-D-2′-deoxy-2′-alpha-fluoro-2′-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment |
US10870672B2 (en) | 2015-03-06 | 2020-12-22 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment |
US10870673B2 (en) | 2015-03-06 | 2020-12-22 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment |
US10815266B2 (en) | 2015-03-06 | 2020-10-27 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment |
US9828410B2 (en) | 2015-03-06 | 2017-11-28 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment |
US10000523B2 (en) | 2015-03-06 | 2018-06-19 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment |
US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
US10946033B2 (en) | 2016-09-07 | 2021-03-16 | Atea Pharmaceuticals, Inc. | 2′-substituted-N6-substituted purine nucleotides for RNA virus treatment |
US11975016B2 (en) | 2016-09-07 | 2024-05-07 | Atea Pharmaceuticals, Inc. | 2′-substituted-N6-substituted purine nucleotides for RNA virus treatment |
US11452714B2 (en) | 2017-05-23 | 2022-09-27 | Regents Of The University Of Minnesota | Antibacterial agents including histidine kinase inhibitors |
WO2018217884A1 (en) * | 2017-05-23 | 2018-11-29 | Regents Of The University Of Minnesota | Antibacterial agents including histidine kinase inhibitors |
US11690860B2 (en) | 2018-04-10 | 2023-07-04 | Atea Pharmaceuticals, Inc. | Treatment of HCV infected patients with cirrhosis |
US11767337B2 (en) | 2020-02-18 | 2023-09-26 | Gilead Sciences, Inc. | Antiviral compounds |
US11707480B2 (en) | 2020-02-27 | 2023-07-25 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
US11738038B2 (en) | 2020-02-27 | 2023-08-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
US11813278B2 (en) | 2020-02-27 | 2023-11-14 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
WO2021221983A1 (en) * | 2020-04-28 | 2021-11-04 | Southlake Pharmaceuticals, Inc. | Interferon tau as antiviral therapy |
US11697666B2 (en) | 2021-04-16 | 2023-07-11 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
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