WO2003105766A3 - Rsk inhibitors and therapeutic uses thereof - Google Patents

Rsk inhibitors and therapeutic uses thereof Download PDF

Info

Publication number
WO2003105766A3
WO2003105766A3 PCT/US2003/018734 US0318734W WO03105766A3 WO 2003105766 A3 WO2003105766 A3 WO 2003105766A3 US 0318734 W US0318734 W US 0318734W WO 03105766 A3 WO03105766 A3 WO 03105766A3
Authority
WO
WIPO (PCT)
Prior art keywords
rsk
present
inhibition
therapeutic uses
proliferation
Prior art date
Application number
PCT/US2003/018734
Other languages
French (fr)
Other versions
WO2003105766A2 (en
Inventor
Jeffrey A Smith
Deborah A Lannigan-Macara
Celeste E Poteet-Smith
Sidney M Hecht
Yaming Xu
David L Brautigan
Original Assignee
Univ Virginia
Jeffrey A Smith
Deborah A Lannigan-Macara
Celeste E Poteet-Smith
Sidney M Hecht
Yaming Xu
David L Brautigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Virginia, Jeffrey A Smith, Deborah A Lannigan-Macara, Celeste E Poteet-Smith, Sidney M Hecht, Yaming Xu, David L Brautigan filed Critical Univ Virginia
Priority to EP03760343A priority Critical patent/EP1539781A4/en
Priority to US10/517,328 priority patent/US20050233985A1/en
Priority to AU2003251513A priority patent/AU2003251513A1/en
Priority to CA002488864A priority patent/CA2488864A1/en
Publication of WO2003105766A2 publication Critical patent/WO2003105766A2/en
Publication of WO2003105766A3 publication Critical patent/WO2003105766A3/en
Priority to US11/524,159 priority patent/US20070049539A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones

Abstract

The present invention is directed to novel compounds and compositions that have Rsk specific inhibitory activity. In addition, inhibition of Rsk by the present compounds has been discovered to halt the proliferation of cancer cell lines while having little effect on the proliferation rate of normal cells. Therefore, the present invention identifies Rsk as a target for therapeutic intervention in diseased states in which the disease or the symptoms can be ameliorated by inhibition of Rsk catalytic activity.
PCT/US2003/018734 2002-06-12 2003-06-12 Rsk inhibitors and therapeutic uses thereof WO2003105766A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP03760343A EP1539781A4 (en) 2002-06-12 2003-06-12 Rsk inhibitors and therapeutic uses thereof
US10/517,328 US20050233985A1 (en) 2003-06-12 2003-06-12 Rsk inhibitors and therapeutic uses thereof
AU2003251513A AU2003251513A1 (en) 2002-06-12 2003-06-12 Rsk inhibitors and therapeutic uses thereof
CA002488864A CA2488864A1 (en) 2002-06-12 2003-06-12 Rsk inhibitors and therapeutic uses thereof
US11/524,159 US20070049539A1 (en) 2002-06-12 2006-09-20 Rsk inhibitors and therapeutic uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38800602P 2002-06-12 2002-06-12
US60/388,006 2002-06-12
US44955303P 2003-02-24 2003-02-24
US60/449,553 2003-02-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/524,159 Division US20070049539A1 (en) 2002-06-12 2006-09-20 Rsk inhibitors and therapeutic uses thereof

Publications (2)

Publication Number Publication Date
WO2003105766A2 WO2003105766A2 (en) 2003-12-24
WO2003105766A3 true WO2003105766A3 (en) 2004-03-11

Family

ID=29739979

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/018734 WO2003105766A2 (en) 2002-06-12 2003-06-12 Rsk inhibitors and therapeutic uses thereof

Country Status (4)

Country Link
EP (1) EP1539781A4 (en)
AU (1) AU2003251513A1 (en)
CA (1) CA2488864A1 (en)
WO (1) WO2003105766A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920393D0 (en) 1999-08-27 1999-11-03 Medix Scient Uk Limited Plant extract mixtures and their uses
KR100590818B1 (en) 2004-10-11 2006-06-19 재단법인서울대학교산학협력재단 The use of direct activation by organic agents of p90 ribosomal S6 kinase 1 RSK1 for prevention and treatment of diabetes, obesity and metabolic syndrome
EP1845778A2 (en) * 2005-01-10 2007-10-24 University Of Virginia Patent Foundation Synthesis of inhibitors of p90rsk
WO2006132401A1 (en) * 2005-06-07 2006-12-14 Banyu Pharmaceutical Co., Ltd. Method for evaluation of compound using rsk1
GB0512206D0 (en) 2005-06-15 2005-07-27 Biosynth As Synthesis
US7659313B2 (en) 2007-09-13 2010-02-09 Gateway Health Alliances, Inc. Methods and related compositions using specific indanes to reduce weight and inhibit lipase, α-amylase and α-glucosidase activity in mammals
GB0718870D0 (en) * 2007-09-27 2007-11-07 Univ Dundee Modulation of RSK
US9040673B2 (en) 2009-08-14 2015-05-26 University Of Virginia Patent Foundation Synthesis and identification of novel RSK-specific inhibitors
WO2013181742A1 (en) * 2012-06-04 2013-12-12 Phoenix Molecular Diagnostics Ltd. Methods of inhibiting rsk for treatment of breast cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066721A2 (en) * 1999-04-30 2000-11-09 Beth Israel Deaconess Medical Center Decreasing adipose mass by altering rsk2 activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066721A2 (en) * 1999-04-30 2000-11-09 Beth Israel Deaconess Medical Center Decreasing adipose mass by altering rsk2 activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1539781A4 *

Also Published As

Publication number Publication date
WO2003105766A2 (en) 2003-12-24
EP1539781A2 (en) 2005-06-15
AU2003251513A1 (en) 2003-12-31
EP1539781A4 (en) 2009-12-02
CA2488864A1 (en) 2003-12-24
AU2003251513A8 (en) 2003-12-31

Similar Documents

Publication Publication Date Title
NO20061194L (en) Mitotic kinesin inhibitors
MXPA06010900A (en) Inhibitors of histone deacetylase.
GEP20125635B (en) Inhibitors of human phosphatidyl-inositol 3-kinase delta
MY145306A (en) Thieno [3,2-d] pyrimidine derivative useful as p13k inhibitor
IL203448A (en) Azabiphenylaminobenzoic acid derivatives for use in the treatment or prevention of a pathological condition or disease susceptible to amelioration by inhibition of dhodh and pharmaceutical compositions comprising them
GB0423653D0 (en) Pharmaceutical compounds
GEP20104994B (en) Tetrahydroindolone and tetrahydroindazolone derivatives
YU21702A (en) Substituted indoles for modulating nfkb activity
MX2009000333A (en) Pyrrolopyrimidines for pharmaceutical compositions.
SG155188A1 (en) Pyrrole derivatives as pharmaceutical agents
EP3363797A8 (en) Oral dosage form of apoptosis signal-regulating kinase inhibitors
IL217623A (en) Substituted amino-carbonyl-boronic compound
DE602004026407D1 (en) Histondeacetylase-hemmer
MXPA05013224A (en) Pyridinyl carbamates as hormone-sensitive lipase inhibitors.
WO2007084391A3 (en) Thiazole compounds as protein kinase b ( pkb) inhibitors
ZA200902384B (en) Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors
TW200745124A (en) Azepinoindole derivatives as pharmaceutical agents
WO2006106326A8 (en) Substituted heterocycles and their use as chk1, pdk1 and pak inhibitors
NO20083267L (en) Azaindole inhibitors of aurora kinases
MX2009004077A (en) Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors.
MX2009004745A (en) 1,2,3-triazole derivatives as sigma receptor inhibitors.
MX2008001982A (en) O-nitro compounds, pharmaceutical compositons thereof and uses thereof.
PL1656348T3 (en) Acetylene derivatives as inhibitors of histone deacetylase
YU40502A (en) 4-pyridinyl-n-acyl-l-phenylalanines
WO2007024574A3 (en) Topical formulations of histone deacetylase inhibitors and methods of using the same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 10517328

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2488864

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003760343

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003760343

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP