WO2003104189A3 - 4-pyrazol-phenylalanine derivatives as ace-nep inhibitors - Google Patents

4-pyrazol-phenylalanine derivatives as ace-nep inhibitors Download PDF

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Publication number
WO2003104189A3
WO2003104189A3 PCT/GB2003/002502 GB0302502W WO03104189A3 WO 2003104189 A3 WO2003104189 A3 WO 2003104189A3 GB 0302502 W GB0302502 W GB 0302502W WO 03104189 A3 WO03104189 A3 WO 03104189A3
Authority
WO
WIPO (PCT)
Prior art keywords
ace
pyrazol
phenylalanine derivatives
nep inhibitors
formula
Prior art date
Application number
PCT/GB2003/002502
Other languages
French (fr)
Other versions
WO2003104189A2 (en
Inventor
Anthony William James Cooper
Jacqueline Elizabeth Mordaunt
Simon Peace
Paul William Smith
Steven Smith
Original Assignee
Glaxo Group Ltd
Anthony William James Cooper
Jacqueline Elizabeth Mordaunt
Simon Peace
Paul William Smith
Steven Smith
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Anthony William James Cooper, Jacqueline Elizabeth Mordaunt, Simon Peace, Paul William Smith, Steven Smith filed Critical Glaxo Group Ltd
Priority to AU2003232362A priority Critical patent/AU2003232362A1/en
Publication of WO2003104189A2 publication Critical patent/WO2003104189A2/en
Publication of WO2003104189A3 publication Critical patent/WO2003104189A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to compounds of formula (I) wherein R<1> represents benzyl; R<2> represents pyrazole; or a pharmaceutically acceptable derivative thereof. The invention also relates to pharmaceutical compositions containing compounds of formula (I) and to the use of compounds of formula (I) in medicine, particularly in the amelioration of a clinical condition for which a ACE and/or NEP inhibitor is indicated.
PCT/GB2003/002502 2002-06-07 2003-06-05 Compounds WO2003104189A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003232362A AU2003232362A1 (en) 2002-06-07 2003-06-05 4-pyrazol-phenylalanine derivatives as ace-nep inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0213122.5 2002-06-07
GB0213122A GB0213122D0 (en) 2002-06-07 2002-06-07 Compounds

Publications (2)

Publication Number Publication Date
WO2003104189A2 WO2003104189A2 (en) 2003-12-18
WO2003104189A3 true WO2003104189A3 (en) 2005-09-01

Family

ID=9938170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/002502 WO2003104189A2 (en) 2002-06-07 2003-06-05 Compounds

Country Status (3)

Country Link
AU (1) AU2003232362A1 (en)
GB (1) GB0213122D0 (en)
WO (1) WO2003104189A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7855291B2 (en) 2005-12-29 2010-12-21 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
US7897763B2 (en) 2005-12-29 2011-03-01 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
DK1984344T3 (en) 2005-12-29 2013-01-14 Lexicon Pharmaceuticals Inc Multicyclic amino acid derivatives and methods for their use
ES2848152T3 (en) 2007-08-24 2021-08-05 Tersera Therapeutics Llc Methods for preparing compounds based on 4-phenyl-6- (2,2,2-trifluoro-1-phenylethoxy) pyrimidine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997024342A1 (en) * 1995-12-28 1997-07-10 Zambon Group S.P.A. Thiol derivatives with metallopeptidase inhibitory activity
WO2003068725A2 (en) * 2002-02-15 2003-08-21 Glaxo Group Limited Process for the preparation of 4-hetero-substituted phenylalanine derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997024342A1 (en) * 1995-12-28 1997-07-10 Zambon Group S.P.A. Thiol derivatives with metallopeptidase inhibitory activity
WO2003068725A2 (en) * 2002-02-15 2003-08-21 Glaxo Group Limited Process for the preparation of 4-hetero-substituted phenylalanine derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHRÖDER E ET AL: "Arzneimittelchemie passage", ARZNEIMITTELCHEMIE GRUNDLAGEN NERVEN, MUSKELN UND GEWEBE, XX, XX, 1976, pages 30 - 33, XP002186820 *

Also Published As

Publication number Publication date
GB0213122D0 (en) 2002-07-17
WO2003104189A2 (en) 2003-12-18
AU2003232362A8 (en) 2003-12-22
AU2003232362A1 (en) 2003-12-22

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