WO2003041499A2

WO2003041499A2 - Bactericides based on metal-chelate complexes and disinfecting composition

Info

Publication number: WO2003041499A2
Application number: PCT/RU2002/000484
Authority: WO
Inventors: Viktor Stanislavovich Polyakov; Valeriy Vasilievich Ermilov; Vladimir Semenovich Kuzmin; Oleg Ivanovich Lukashov
Original assignee: Veckis Industries Ltd.
Priority date: 2001-11-12
Filing date: 2002-11-11
Publication date: 2003-05-22
Also published as: AU2002363782A1; WO2003041499A3

Abstract

The invention relates to bactericide agents which can be used as anti-bacterial preparations for medicine, veterinary and the food industry and also for producing disinfecting means and products for domestic use i.e. cleaning, washing and cosmetic products. Said invention also relates to disinfecting compositions used for medicine, the food industry etc. The inventive bactericides based on metal-chelate complexes comprise metal-chelate complex compounds and contain a monodentate ligand having an affinity to hydrogen ion, bi- or polydentate ligands being used as a chelate ligand. The inventive disinfecting composition based on metal-chelate complexes comprises a metal-chelate complex compound which contains a monodentate chelate ligand having an affinity with hydrogen ion, an ionogenic surface-active substance and a solvent. The inventive product is non-toxic, relates to the IV class of low-hazard compounds and can be used within a large range of environmental temperatures.

Description

BICYCIDES

Area of technology

The invention relates to bactericidal substances and com pacts,

The quicker may be used as an antibacterial product.

in medicine, veterinary medicine, food industry, industrial production

disinfecting substances, also the proposed bactericidal substance and

The company can be used in agriculture, in medicine, in

labs of any kind, on the contrary, by the population in everyday life, on the contrary

For household goods: clean, washing,

cosmetic products and dr. The proposed offer may be used in

Qualitative universal disinfectant, sterilizing and

a bactericidal agent in various environmental conditions.

PREVIOUS LEVEL OF TECHNIQUE

It is known that one of the most effective disinfectants

CIRCUITS are compounds and compounds containing an “active” substance, such as

Good lime, chlamines, hypochlorites, etc., the operation of which is based

on the oxidative descriptions of proteinaceous microorganisms.

The most distributor of this disinfectant group,

Produced in large volumes (hundreds of thousands per year) in the most Produced in large volumes (hundreds of thousands per year) in the most

The developed countries are the sodium salt of diethylisocyanate,

Of course, one of the many written methods, for example,

.У.δуτηеδ, ΜοηЗЫУ СЕТ. Сο., ΡаΙ. υδ 3035056, 05.15.62). Κ disadvantages

disinfectants of oxidatively-harmful effects are not high

environmental and chemical safety for the biosphere. For man and

lively animals are toxic, in the case of natural objects they destroy microorganisms

non-pathogenic microcosm. Therapies themselves, and more of them

They have a limited scope of action and are in possession of a limited

action.

Β Last years, a new class of disinfectants - antiseptics - has appeared

constituent useful compounds with guanidine

groups. The most famous is polymexamethylene guanidine.

Chloride (copyright certificate of the USSR Ν ° 1616898, 1990; copyright

certificate CCC Ν ° 1808832, 1993), which is resolved in Russia for

Applications as a disinfectant in health and veterinary medicine. Κ

the disadvantages of this disinfectant group are the following

comparatively low efficiency, complexity of products, high

the price. Otherwise, the owners of this class have a high Toxicity in case of falling into the stomach - is not present in class III of danger:

L ₅ for white and brown pigs, equal to 760 and 900 mg / kg, respectively.

Disinfectants having a bactericidal effect are also described.

on the basis of complex mixtures of some metals (copper (P), nickel (P), iron (P))

with nitrogen and serous Shifnovy knowledge (Zhu Xinde et al., J.

Geochemistry, 1991, τ. 36, vy.5, p. 1240). One of these connections

are complex in service, have a high cost, are ecologically unsafe.

Otherwise, the toxic hygiene of these compounds has not been studied.

and the impact on the internal bodies of the person.

The closest analogue for bacteria on the basis of healthy

Compound of metals is a bactericide, which is a hazard

Composition including a compound of a metal with α-amino acid and

disinfectant (W, patent No. 6242009, 2001).

Β With the specified patent, the antimicrobial combination includes

Obtained in an acidic environment is a mixture of metal and α-amino acid, as well as

additional antimicrobial substances, mainly, derivative

Hydroxycidine or oxygene, which are themselves on their own

strong disinfectants. Β Patent description

complex of metals with amino acids in an acidic environment, in the presence of

mineral acids. It is well known from the literature (D. Skug, D. West, Basics Analytical Chemistry, book 1, ed. “Ρиρ”, Μ., 1979) healthy complexes

metal in an acidic environment exists in a very insignificant concentration.

For example, such a strong best-selling agent is like EDA, in full

binds metal ions into complex complexes with larger values and larger values

6.0. For weaker, better-looking agents, this is not a problem.

natural α-amino acids, the value of ρΗ of the medium should be higher

for the complete binding of all metal ions into stable healthy

multiplexes. The studies we have carried out were indicated for

indicated in the patent of the USA 200 ° 6242009 amino acids and metal transitions

in non-dissociated healthy complexes, it may happen only

values ρΗ> 7.0, and the addition of mineral acids, in accordance with

The methods described in the patent result in the destruction of the human body.

kompleksov. When this happens, the amine group is operated on.

amino acids, and the metal exists in foreign form. Antimicrobial

ACTIVITIES UNDER THE USE PATENT Ν ° 6242009

Due to the activity, they are not chelate complexes, but metal ions,

In short, as it is known from the literature, it also possesses a separate

Bactericidal activity, in particular, arising from the use of ions

silver. It should also be noted that in the patent of the USA 6242009 are given in

the quality of the compound of arsenic and selenium, whose bacterial ACTIVITY MAY BE DUE TO HIGH TOXICITY TO RELEASE

to all living organisms, including humans. Strong disinfectants

substances (acid chloride, waste water) included in the quantity

“ADDITIONAL” COMPONENTS DESCRIBED IN THE PATENT OF THE USA Ν ° 6242009

Complexes are undeniably capable of enhancing their ability to be active.

pribeparata.

Below is described the level of technology for the second invention -

of disinfecting equipment on the basis of a clean metal complex.

One of the most commonly known disinfecting agents is

HERE OF WATER AND PRODUCTS ON HER BASIS. The representative of this group

The product is a disinfectant that contains harmful substances,

magnesium lauryl sulfate, glycerin, oleate sodium, dinatrium salt

ethylenediaminetetoacetic acid (EDA), sodium benzoate and water. (Κ.υ

Patent Ν ° 2108810, 1998). This product is intended for

Disposal of room vacancies, sanitary and technical

Food, underwear, medical devices and not available

FAVORABLE EFFICIENCY. For people and animals it is toxic.

Bactericidal preparations containing lantocin and

a better agent with enhanced activity.

Selective agents may be, for example, ethylenediaminetetoacetic acid (EDA), its salts,

ethylene glycolate acetic acid and citrate (υδ, patent Ν ° 5260271, 1993;

W, patent No. 5334582, 1994).

Κ the analogue is also referred to as the bactericide described above,

Presentation of the offer, including that obtained in an acidic environment

a metal complex with α-amino acid, and also disinfectant. (υδ Ν ° 6242009,

2001).

Also included are bactericidal preparations, including

active substances with methyl chloride (ϋΕ 4 ° 4326866,

1995; υ Ν ° 5206016, 1993; υδ Ν ° 5575991, 1996).

It provides an antisynthetic medium, including

The quality of the material that is available is free of methyl chloride,

mineral or organic acid and a solvent. (Κυ πpatent Ν °

2118174, 1998). This is known to have a bactericidal activity in

The economy of the world is not large and does not possess a sufficient

Efficiency in case of enteric and droplet infections of bacterial and

viral etiology, and also anthrax.

A known disinfectant containing a bacteriocin

improving agent, stabilizing, active-active substance (ПΑΒ), salt and sugar (τυ, patent Ν ° 2163145, 1999). Known means are used.

for the use of napkins used for the treatment of live weight gain.

The closest to it is the disinfectant

Inactive, active, active substances - non-hazardous

a compound, a real active substance, a beautiful complex and

Extruder (Κυ, patent Ν ° 2061497, 1996).

This product is effective when used only

Positive temperature 18-25 ° С. Possibility of inactivation

Bacteria vary between 5-30 minutes.

Ρ с κ ρ τ τ τ τ τ τ τ τ τ τ τ τ

Advanced disinfectant and antibacterial

Compounds are metal compounds, such as

ammonia-acid complexes, ammonia-nitrate and acetate

complexes, ammonia-ethylenediamine-tetraacetate complexes, etc.,

the ability to associate aminocarboxylic protein groups with

the construction of them. They are bactericidal reagents with

a wide range of direct and indirect actions, irreversibly suppresses

pathogenic microcirculation. Communicative Action Mechanism

The metal is based on the blocking of amino acid groups of the protein Businesses and fragmentation systems of microorganisms. In the first stage

Development of associations with a well-known complex takes place, then

the molar ligand is replaced by an amino acid group protein, which

It comes with a complete block of metabolic processes in the world and,

Correspondingly, to the death of microorganism.

The toxic effect on humanity is proposed

Preferred complexes are available in the IV safety class. Dosages

They are used on a pharmaceutical and bactericidal treatment, they do not indicate

severely expressed, or annoying, actions on the skin and

mucous membranes.

Effectiveness of the offer offered for the patenting of the smartcomplexes

The metal is based on the substitution of an amine group with a strong group

squirrel without changing the ρΗ environment and without disturbing the original, secondary,

the protein and quadratic structure of the protein. Suggested Good

Complexes bind amino acid groups of fibrous proteins.

The multiplex connections practically do not have an effect on the organism

people, simple compounds containing amino acids,

withdrawn from humanism in the process of exchange exchanges. Practical

influence on the most vital functions of the organism of the bactericidal

Beautiful complexes also do not have. Suggested bactericides, such as and the closest analogue, are related to

metal complexes with chelating ligands, however, due to the fact that

The proposed bactericides are produced in an alkaline, rather than acid, complex.

ρΗ values, they have more than a wider range of uses (other

mechanism of bactericidal action), compared with the analogue in connection with them

environmental safety, low toxic and hygienic

The performance and characteristics of the chemical stability (constants

the stability of the offered units is higher than that of the closest analogs on

a few troubles due to external influences of the environment.

Аче As a prerequisite for ligands, bi- or privately owned ones are used.

ligands of a wide group of organic compounds in their possession

Composition of basic and acidic centers: aminogroups, carboxyalkyl-,

alkylsulfonic-, alkylsulfonic groups.

Аче For the most part, large ligands use ligands that possess

friendly to foreign water - which makes it easier to replace them with

aminogroup protein of microorganism.

Tasks for solving the inventions - bacteria - bacteria on

The basis of the metallurgical complexes of metal is closed

- in an increase in antimicrobial activity, which is achieved at the expense of

the use of bi-and solid ligands, which are in their own structure 10

Complimentary business activities at the active center

A facility in a blocking microorganism that facilitates the development of

of complexes of the type “enzyme-substrate” described in the work (Β. Jenks,

“Realization in Chemistry and Enzymology”, Ed. "Μиρ", -Μ., 1972). According to our data,

Convenient “enzyme-substrate complexes” may not be processed only

preferable compounds having a ligand alpha-amino acids

Fragments, such as glycine, iminodiacetic and nitrous acetic

Acids, ethylenediamine-diacetic and -tetraacetic acids, no and healthy

Compounds with alkylsulfonic and alkaline sulfonates.

- in increase of antimicrobial activity due to

additional ligands replaced by amino-strong

protein groups;

- in the increase of environmental properties, which is achieved at the expense of

USES OF NON-TOXIC HELPING REAGENTS, TRANSMITTING IONS

metals in non-toxic healthy complexes;

- a decrease in the cost of bactericidal complexes due to the fact that, in

On the other hand, cheap ligands are used for cheap things,

Obtained, including from white goods. Respectable

ligands, such as substituted in the α-position of the large group

Derivatives of iminodiacetic and nitrous and acetic acids with various eleven

Residues of amino acid fragments without an amine-rich group

It may be synthesized from a mixture of natural amino acids, which are, in fact,

On the other hand, it comes from a white-consuming community. It makes a difference.

reduce the cost of bactericidal complexes that are synthesized on the basis of

convenient ligands

- Increased stability to external factors due to

Inadequacy of our proposed bactericidal complexes.

Dependence of metal on such environmental factors as temperature, humidity,

the impact of light

- the ability to save without changing the properties of your property

OPERATED PROPERTIES FOR MANY YEARS.

The solution of the specified tasks is achieved by the fact that bacteria,

inclusive solid complex metal compounds also contain

a domestic ligand that possesses a source of foreign food, and in the quality

the desired ligand uses bi-or multiple ligands,

Compounding basic and acidic centers: amine groups,

alkoxy-, alkylsulfonyl-, alkylsulfonyl groups, in that

including: anhydrous amino acids or imiodic acids, or

nitrate acetic acid, and also substituted in the α-position κ

a large group of raw iminodexious or 12

nitrate acetic acid with various residues of amino acids

groups without an amine group or

alkylenediamine-polyacetic acids, as well as substituted in the α-position κ

Large group of polyalkylene-polyamine-polyusaceous derivatives

Acid with various substituents, such as α-carbohydrate or derivatives

ω-phosphonic acid and ethylenediamine phosphoric acid or

Derivatives of ethylene (tiususny) and dietetiusyusny

Acids or Mono-Mineral Compounds, in Large Groups

replaced by phosphotic.

The proposed bactericide contains in its composition:

a) a metal, one of the following: copper (II), zinc,

Calcium, nickel, manganese, carbon, mercury, lead, cadmium;

b) a bi- or solid ligand having large and strong

Improving groups, in particular, such as:

• anions of natural alpha-amino acids (glycine, alanine, valine,

leucine, isoleucine, phenylalanine, tyrosine, προlina, οκsyπροlina, serine,

tereinina, cysteine, cystine, methinine, liver, asparagine

acids, glutamic acid, arginine, lysine, histidine) and other

amino acid; thirteen

• iminodiacetic and nitrous acetic acids, and also

Substituted in α-position of the large group of derivatives

iminodiacetic and nitrate-acetic acids with various residues

amino acid groups without an amine-rich group;

• alkylenediamine-polyacetic acids, as well as substituted in α-

The location of the large group is very flexible.

polyamine polyoxyacids with various residues of amino acids

groups without an amine group;

• Derivatives of the ω-phosphorus and ethylenediamine compounds

tetracycline acid;

• derivatives (tiususny) and

diethylacetic acid;

• monoamine complexes, in large-sized groups

replaced by physical;

c) a compact ligand possessing a source of foreign food,

Such a coke, ammonia, mono- and τ-ethanolamines and τ.π.

The task that is being addressed is the proposed disinfection rate on

The basis of the universal metal complexes is the creation of a universal

disinfectant, antiseptic and bactericidal high 14

efficiency, with an increased short-term effect of the bactericidal effect, with

It is possible to use it in a wide range of good and

negative temperature, suitable for storage for a long time

In the meantime, it is safe in the application, possessing a high bactericidal,

virulicidal, fungicidal, speedy activity and

inconsequential.

Non-disinfectant results

The improvements arising from the solution of the assigned tasks are achieved

It means that, in a disinfectant, including the original

Conventional-active substance, a complex and a converter, in

In the case of a chelate complex, a chelate complex is used.

compound of metals containing a basic ligand possessing

with a source of water, and in relation to it with foreign

partly active substance to the distributor 1- (7-9), and in the quality

The distributor uses distilled water.

The proposed offer is a disinfectant.

Medium, including also, as in the first variant, the original

Portable Active Material, Integrated Circuit and Dispenser.

According to the invention in the second embodiment in the quality of the complex

Also used is a prefabricated metal compound, including fifteen

For the most commonly used bi- or polysynthetic ligand,

additional ligand that is small enough to be able to take advantage of foreign

HUMAN RESOURCES USE THIS AS A USER

distilled water and aliphatic alcohol (Сι - С ₈ ) πρ and the following

mass ratio. %:

a prefabricated metal compound that contains a medium

a ligand possessing a source of hydrogen - 1-30;

original PΑΒ - 0.1-15;

aliphatic cirrhosis (Сι - С ₈ ) - 0.5-95;

distilled water - other.

A yellow, commercially available metal compound containing

A domestic ligand that possesses a natural source of foreign food.

Options may be made on the basis of one of the metals selected

from the following series: copper, zinc, mercury, χροм, manganese, nickel, cadmium,

arsenic, calcium, aluminum, lead, selenium, platinum, gold, titanium, tin or

on the basis of alloys.

Otherwise, in a well-known integrated metal compound, containing

The domestic ligand, which possesses a good source of foreign food, is

A beautiful ligand can be used by one of the bi 16

or solid ligands, such as the anions of natural amino acids,

iminodiacetic acid, nitrite and acetic acid, carbon-substituted

(in the α-position of the large group) are derivative imiodusus and

nitrate acetic acid with various residues of amino acids

Fragments without an amine group, alkylenediamine-polyacetic

Acids, carbohydrate-substituted (in the α-position of the large group)

Various polyalkylene-polyamine polyoxy acids with various

Residues of amino acid fragments without an amine-rich group,

Derivative ω-derivatives of acid, non-derivative

ethylendiphosphate acid, derivative

etieth (taucus) and diethyl diacetic acid,

monoamine complexes, in large groups are replaced by

Physical, or mixture.

With this prefabricated metal interconnect containing

The domestic ligand, which possesses a good source of foreign food, is

A preferable ligand may be used by one of the other options.

following amino acids: isoleucine, phenylalanine, lycine, lysine, methionine,

tropionine, tropin, valine, alanine, glycine, arginine, histidine, or their mixture

Аче On the other hand, a commercially available integrated metal compound

the use of a glycine glycine complex of copper. 17

Otherwise, in the form of a flexible interconnected metal

the possible use of ethylenediaminetheacetate complex of zinc.

In the event of an improper use, you may, for example,

cetylpyridinium halides.

Otherwise, as a rule, you may also use the original

cetyl methyl halides.

Compound metal compounds are effective

disinfectant and anti-bacterial agents. They are

Bactericidal reagents with a wide range of direct-to-antibacterial agents

actions that irreversibly suppress the harmful microcirculation. Christianism

ACTION OF COMPLEX METAL COMPOUNDS BASED ON BLOCK

Amino Acid Protein and Fragment Systems

microorganisms. At the first stage, associations are being formed with

by the complex, then the ligand is replaced

Amino Acid Group Protein, Which Comes to a Complete Unit

metabolic processes in microorganism and, correspondingly, death

mikροορorganism.

The toxic effect on humanity is proposed

The disinfecting equipment is available in the IV class of safety. Doses

These are generally used on the product and the bactericidal treatment are not 18

Indicates an expressive or annoying effect on the skin.

and slimy particles.

Offers on the Basics of Well-Comprehensive Comprehensive

metal compounds practically do not affect the body

people, simple compounds containing amino acids,

withdrawn from humanism in the process of exchange exchanges. Practical

influence on the most vital functions of the organism of the bactericidal

Beautiful complexes also do not have.

Suggested disinfectant options are not available.

complex metals with chelating ligands, which are obtained in

alkaline, and not acidic, values of ρΗ. Investigation of this proposed

Compared to the analogue, they have more than a wide range of

Applications, since they are environmentally friendly and low

Toxic hygiene products based on a different mechanism

bactericidal action. For this reason, the proposed offers prevail

greater chemical stability in relation to external influences

environments (stability constituents of the offered compartments are higher than that of

the closest analogs, for a few tips).

Аче For the most part, large ligands use ligands that possess

with a source of water. It is the property of the owner of the property. 19

the ability to replace a basic ligand with an amine protein

mikροορorganism.

The proposed bacteria bacterium is in its own right.

It is composed of metal, copper (II) or zinc, and also

Domestic ligands possessing a source of foreign food, such as

ammonia, mono-, di- and τρiethanolamines and τ.π.

The resulting bactericidal com pounds have ρΗ> 7.0.

For the synthesis of bactericides, metal salts are used. Synthesis

DISCONTINUOUS PRODUCTS AND HANDLING OF INGREDIENTS

ROOM TEMPERATURE. Аче As a standard, large ligands are used

HARDWARE, POSSIBLE WITH ENVIRONMENTAL WATER.

SIGNIFICANT DISTINCTIVE PRODUCT OFFERS

bactericidal exposures are those that interact (mixing)

Ingredients occur in neutral and alkaline environments and ρΗ> 7.0 in

lack of mineral acid.

With respect to disinfectant indicators, it is possible to

Save that the proposed bactericidal preparations are

self-sufficient and do not require the introduction of additional

disinfecting substances, for example, hydroxycidine, water and

τ.π. 20

The method of synthesis of a glycine glycine complex of copper and

The ethylenediaminetaceous acid complex of zinc is known from the following

sources:

a) Η. Е Β ϊ ϊ τ τ Τ Τ ο ο ο ο ϊ ϊ // η η // // // // // // // // / // Β ϊ Ι Ι // //

Οеτ.δЬеη, Сηетϊδсηеη ΟеδеΙΙδсЬиϊτ, 1909, bά 42, b. 1, 8. 354-376;

b) Ηοгϊϊϊϊ "" ""ϊϊϊτττ ζζζϊΚΚΚϊδδδδδδηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηηη Αгтаϊеη άег

See, 1877. V.189, 8.36.

c) "δуηϊеΙϊс Ρгοάисύοη аηά ШΗζаποη οι ^" ϊтϊηο Αсϊάδ ", Εά. Τ.Κаηекο,

Υ.Ιζитϊ, Ι. SYSaЪa, λνϋеу, Ν.-Υ., 1974.

d) Dyatlova Η.Μ. and dρ. Industrial and industrial complexes, Μ .: -

Chemistry, 1988.

Antimicrobial activity of the glycine glycine complex of copper,

ethylenediaminetaceous complex of zinc and the best practices on their basis

was investigated in the Scientific and Research Institute of Disinfection of the city of

October.

Comparison of ingredients in the offered products

In order to ensure the best possible

the technological characteristics of the drug and the drug did not decrease

stable properties.

Intervals of values of incentives in the composition: 21

Yellow metal complex 1% -30%

Original PΑΒ (galogenides of the fourth ammonian bases -,

С _ϊ2 - С _{ϊб -} alkyltrimethylammonium, di (С ₈ -Сю-alkil) dimethylammonium, Сι ₂ -Сι ₆ -

alkylpyridinium, in particular the halogenides of cetylpyridinium and

net% 0.1% - 15%

Pulmonary disease (Сι - С) 0.5% - 95%

Food 3% - 98%

The proposed intervals of the values of the concentrations of ingredients in

The offers are due to the achievement of the above bactericidal,

fungicidal and competitive effectiveness of the operation.

TO REACH THE REQUIRED TECHNICAL RESULTS POSSIBLE

Usage of the original genetically generated halides

Ammonium foundations, and the name Сι ₂ -С _ϊ ---alkyltrimethylammonium, di (С ₈ -Сю-

Alkyl) dimethylammonium, C _{ϊ 2} -C- _b -alkylpyridinium, in particular, halides

cetylpyridinium and cetylmethylammonium.

BEST MODE FOR CARRYING OUT THE INVENTION

The method of radiation of bacteria on the basis of healthy com plexes

metals. 22

Bactericides on the basis of healthy metallurgical complexes may be

It was obtained by mixing organic bi-or multiple ligands in

in the form of salts of alkali metals with metals or salts of metals and

household ligands.

The resulting bactericidal complexes have ρΗ> 7.0.

Technology.

Synthesis of Bactericides

For the synthesis of bactericides, metal salts, anions of bi- or

solid ligands in the form of salts containing in the carton

alkaline or alkaline-earth metals, ammonium group. Synthesis

Disposal of water and stirring and room temperature.

Аче As a standard, the ligands used are suitable for the manufacture of materials,

Owners of equipment for business.

For example, 1.

At the same time, 0.4 g of sodium hydroxide is dissolved in 20 cm distilled

deionized water, added by stirring 1.46 g of L-lysine.

Then, while stirring, add 1.36 g of pure zinc to the products.

The resulting mixture is mixed with 0.75 cm ^{3 of a} 25% ammonia solution in water 23

water and dilute the required concentration of concentrate and anti-bacterial

Processing facilities.

For example, 2.

Flask is poured with 1.22 cm of 25% ammonia solution of 15 ml of water and

add 2.37g ethylenediamine tetraacetic acid - alkaline

It is necessary for the conversion of acid into a degradable diammonium salt. Β

The resulting disinfectant and stirring add 1.09g

copper dichloride and nodulate 0.48 g of ethanolamine Developed product

Obtains a dark blue color.

Bactericidal activity.

To evaluate the effectiveness of the antibiotic action were

Studies on different species of pathogenic microorganisms: Ε. Сοϊι,

intestinal sticks, catastrophic, enteric, enteric, enteric amoeba,

rhichiomonada, espei of Jesgeiδ, segei of δ, helminth eggs (ostrich,

7 0 ascaraida). The number of microbodies in the extractor hood was 10 - 10

tel / mkl.

Β 1000 ml of hood extracts the calculated quantitatively obtained

Bactericide disinfectants, the liquid was mixed, kept at 36 С in 24

flow 60 minutes The territory of the territory of the USA has provided access to the facilities of a large

at the Endo environment and at the environment, processed machinery was protected at

meat and casein broths.

High efficacy was observed for all used bacteria.

antibacterial action. Π π π им е,, πΗ π а б π π π Η π

1, in doses of 30 ppm, a decrease in the concentration of Ε is ensured. Saturday 9th,

at that time, as a bactericide obtained in Example 2, in doses of 4, it decreases

accent Ε. community on 5 days (from 5.10 ⁵ to 0).

It should be noted that the bactericidal preparation is an example of

the activeness is achieved solely due to the properties obtained

units without the introduction of additional disinfectants.

Significant differences in the proposed bactericidal complexes.

Interaction (mixing) of the metal salt with the amino acid (mixture

amino acid) occurs in neutral and alkaline environments and is> 7.0 in

lack of mineral acid.

The reactive activity is dominated by healthy complexes of metals and

Compounds that have a large and comfortable group that are

exist for ρΗ ≥ 7.0. The presence of inorganic acid destroys

The perfect complex is due to the loading of the amine nitrogen atom. 25

We are patented by the complex complexes of metals and a wide group

Compounds that are in their own right are large and comfortable

groups.

In relation to the disinfecting properties of bactericidal

Please note that they are self-sufficient and are capable of

be used without the introduction of additional disinfecting agents,

for example, hydrochloride, acid and τ.π. Οdisc

Bactericides on the basis of chelated metallocomplexes of metals can be used

Also included in the composition of the proposed disinfectants.

The following are the results of the disinfection of radiation

on the basis of chelate complexes of metals.

Example 3.

At a distance of 2.0 g of hydroxide sodium in 50 cm distilled

water, add by stirring 3.75 g of glycine. Then πρ and

When stirring, add 6.8 g to the resulting product.

zinc and add 3.75 cm of 25% ammonia in water. Separately

A solution of 0.43 g of cetyl ethylethyl chloride in a mixture of 1.2 g of ethylene glycol

and 15.3 cm ^{3 of} water. Mix up, mix and dilute the water

the required concentration of the product and the antibacterial processing of the objects. 26

Example 4.

The flask is filled with 6.1 cm ^{3 of} 25% ammonia solution of 25 ml of water and

add 11.85 g of ethylenediamine tetraacetic acid. Β πο radiated

Saving and stirring, add 5.45 g of copper dichloride and

They treat 2.4 g of ethanolamine. The newly developed product is receiving a dark

blue stitching. Separately prepared 8.1 g

dodecylbenzyltromethyl chloride in a mixture of 7.3 cm ^{3 of} isopropyl alcohol

alcohol and 10 cm of water. Both merge and dilute the water to the desired

Concentration of the device and the anti-bacterial processing of the objects.

Example 5.

At the same time, 0.4 g of sodium hydroxide is dissolved in 20 cm ³ distilled

water, added by stirring 1.46 g of L-lysine. Then πρ and

While stirring, add 1.36 g of pure zinc to the product. Received

The mixture is mixed with 0.75 cm of a 25% ammonia solution in water. Дτ

Prepares 12.0 g of cetylpyridinium chloride at 56.0 cm from

social. Κ The last slow, add, add water

Amino Acid Complex of Zinc, stir and dilute the water

the required concentration of the product and the antibacterial processing of the objects. 27

Example 6.

Blend a beautiful complex compound of metals containing

a domestic ligand that possesses a source of foreign food, with

ponogenic, in particular, as indicated in Example 1. Add

distilled water at a concentration of 10% or 30%, τ. e. πρ and

Comparison of the components 1 to 9 or 7.

Example 7.

Mix the ingredients as described in Example 2 in the following

quantity in%:

The Chemically Integrated Metal Compound, which contains a ligand that is commercially available, has a good foreign water content of 30

ingenious ПΑΒ - 15

aliphatic sirpi (Сι - С ₈ ) - 0.5

Distilled water - 54.5

Example 8. Mix the ingredients as described in Example 2 in

the following quantities in mass. %:

The yellow complex compound of the metal, containing a ligand that is commercially available, has a friendly foreign water 2 28

ingenious ПΑΒ 1

aliphatic syrup (C) - C ₈ ) 95

Distilled water 2

Example 9.

Mix the ingredients as described in Example 3 in the following

quantities in wt.%:

χelaτnοe κοmπleκsnοe sοedinenie meτalla, sοdeρzhaschee mοnοdenτaτny ligand οbladayuschy sροdsτvοm κ iοnu vοdοροda 1 iοnοgenny PΑΒ 5 aliφaτichesκy sπiρτ (Sι - C ₈₎ 20

Distilled water 74

Example 10.

Mix the ingredients as described in Example 3 in the following

quantities in mass. >:

A preferential metal compound containing a ligand containing a pure foreign substance 2

ingenious ПΑΒ 0, 1

aliphatic sirp (Сι - С ₈ ) 30

Distilled water 67.9

The bactericidal activity of the disinfectant. 29th

To investigate the disinfecting properties of samples in the quality test

microorganisms used vegetative forms of bacteria Ε. Soi

(shtsshm 1257), simulating enteric pathogens - gram-

negative bacteria; ZshkruΙοssoss αigesh (pcs αmm 906), simulating

Infections of the respiratory pathways and the causative agent of internal infections -

gamma-positive bacteria, as well as a profitable bacterium of the United States

segesh (pcs 96 mm), simulating anaerobic infection - gas

gangrene, stolbnyak and anthrax.

Primary studies of metallic complexes of metals, for example,

ammonia of copper glycine showed a significant high activity in

With respect to vegetative vegetation (see table 1).

In order to enhance the anti-reactivity, in particular,

impaired properties, in the products of the metal complexes were introduced

Ingredients ΑΒ (cetylpyridinium chloride, cetylmethylamide

bromide). Thus, the resulting optimization on the basis of ammonia of glycine

copper and cetyl methyl bromide (preparation 1, see table 1)

The proposed synergy of our action in relation to the impact of

Bacterium while maintaining high activity in relation to

Gross and negative bacteria. thirty

NEAR RECEPTIONS ON THE BASIC OF ZINC BOTH ELECTRIC COMPANIES

activity in relation to the enumerated species of bacteria has been shown to be safe

2 (see table 1) on the basis of a 2-aminoethyl ethylenediamine tetraacetate

the complex of zinc and cetylpyridinium chloride.

RESEARCH RESEARCH COMPOSITION OF 5% NEW PRODUCT

zinc ethylenediaminetate in an aqueous-alcoholic solution (70> in volume

IPS) has shown the effectiveness of vegetative forms of bacteria

A dilution of 128 times, in relation to anthrax (sores) and dilution in

16 p.

The proposed universal eco-friendly safe bactericidal and

The device is intended for the disinfection of basic forms and species of the pathogen

miracles, including those that are. Immediately overpowered

eco-friendly properties, which are achieved through the use of

non-toxic chemical reagents, converting metals in

non-toxic healthy complexes;

Disinfecting agent:

- reduce the cost of bactericidal complexes;

- Improve sustainability for external reasons.

Lack of proposed bacterial steroidal complexes of metals 31

changes in properties depending on temperature, humidity, exposure

light;

- to store without changing the properties of their operating properties in

many years.

As a result of the tests carried out, it is established that

the use of ingredients below the minimum

values of the composition there is a decrease in bactericidal efficacy and

stability of the medium.

When using the contents of the ingredients specified above

maximum values of the composition there is a decrease in stability

kompotsitsii.

The standard tests carried out showed high efficiency.

For the treatment of pathogens, such as:

- enteric infections (gross-negative bacteria) - Pseudomonas aeruginosa

fingering, dysentery, salmonella;

- infection of the respiratory tract and internal infections

(positive bacteria) - staples, strains, micros, and

dρ-;

- anaerobic infections - ranoe infections (complete),

- anthrax (sπορы) and others. 32

Effectively affects viruses (hepatitis, herpes, hypertrophy)

infections, thoracic infections).

Buffer Bactericidal Comprehensive Warranty

the required bactericidal effect and any other indicators of human exposure,

The average value is ρΗ = 7.6 ± 0.5.

Slightly used for infection and

disinfection of infected livestock and livestock, and

ALSO BETWEEN MOST MATERIALS.

Due to its composition and principle of operation, the harmlessness is harmless to

people and domestic animals, non-toxic, do not cause skin irritation,

Chemically neutral with respect to consumable materials and

To fabrics from natural and synthetic fibers, do not cause crashes

metals.

When applying the benefit to each person, a bactericidal effect

stored for at least 2 hours; on application and on application

materials, cloths and protective straps - for 24 or more hours.

The application interval was as follows: -20 ° С to + 40 ° С ÷

+ 50 ° С, for rotations from -50 ° С to + 50 ° С. Intact activity

Compromise causes the death of 99.99% of mixtures 33

On the basis of the parameters of the direct toxicity, they are not available in the IV class

small connections.

USE OF EFFICIENT QUANTITATIVE COMPONENTS IN

combination has a synergistic effect, improving disinfectants

COMPETITION PROPERTIES.

Intended use

Intended use of the proposed offer

The above disclosed examples of the invention.

34

Table 1.

Inactivity of samples.

Claims

35ΦΟΡΜULΑ IZBΟIA

1. Bactericides on the basis of healthy metal complexes, inclusive

Integrated metal compounds, distinguished by the fact that

contains:

- a large ligand that possesses a source of foreign food,

- and in the quality of the desired ligand bi-or solid-state ones are used

ligands.

2. Bactericides πο π. 1, characterized in that, for the most part,

ligands are used anions of natural amino acids.

3. Bactericides πο π. 1, characterized in that, for the most part,

the ligand is used iminoacetic acid.

4. Bactericides πο π. 1, characterized in that, for the most part,

ligand is used nitrate and acetic acid

5. Bactericides πο π. 1, characterized in that, for the most part,

the ligand is used carbohydrate-substituted (in the α-position is large 36

group) derivative iminodius acids with various residues

Amino Acid Fragments without an Amino Acid Group.

6. Bactericides πο π. 1, characterized in that, for the most part,

the ligand is used carbohydrate-substituted (in the α-position is large

group) derivative nitrous and acetic acids with various wastewater

Amino Acid Fragments without an Amino Acid Group.

7. Bactericides πο π. 1, characterized in that, for the most part,

the ligand is used alkylenediamine polyuretic acids.

8. Bactericides πο π. 1, characterized in that, for the most part,

the ligand is used carbohydrate-substituted (in the α-position is large

group) derived polyalkylene-polyamine polyuretic acid with

various residues of amino acids without an amine acid-rich

groups.

9. Bactericides πο π. 1, characterized in that, for the most part,

the ligand is used as a derivative of the ω-phosphonic acid. 37

10. Bactericides πο π. 1, characterized in that, for the most part,

the ligand is used with ethylenediamine acid.

11. Bactericides πο π. 1, characterized in that, for the most part,

the ligand is used as a derivative of acid (acetic acid) acid.

12. Bactericides πο π. 1, characterized in that, for the most part,

the ligand is used with diethyl diacetic acid.

13. Bactericides πο π. 1, characterized in that, for the most part,

the ligand is used for monoamine compounds, which are in large quantities

groups are replaced by phasic.

14. Disinfecting agent, including virgin

a portable active substance, a complex and a device,

ο τ и а а с,,

in the form of a chelate complex, a chelate complex is used

metal compound containing a basic ligand possessing

food and drink, 38

in relation to it with an indigenous maneuverable active substance

to the manufacturer 1- (7-9),

and as a distributor, use distilled water.

15. Disinfectant πο π. 14,

ο τ и а а с

Preferred Integrated Metal Compound Containing

The domestic ligand, which possesses a friendly foreign product, has been carried out

on the basis of one of the metals selected from the following series: copper, zinc,

mercury, chromium, manganese, nickel, cadmium, arsenic, calcium, aluminum, lead,

selenium, platinum, gold, titanium, tin or on the basis of their alloys.

16. Disinfectant πο π. 14 or 15

ο τ и а а с

in a well-known interconnected metal containing

The domestic ligand, which possesses a good source of foreign food, is

The desired ligand is used as one of the bi- or multiple ligands,

such as anionic acids, iminodic acid,

nitrate acetic acid, carbohydrate-substituted (in α-position κ

large group) derivative iminus dius and nitrous impurities 39

Acid with various residues of amino acids without

amine acid, alkylene diamine polyoxy acids, carbon

substituted (in the α-position of the large group) π derivatives

polyalkylene-poliaminopolyacetic acid with various residues

Amino Acid Fragments without an Amino Acid Group, Derivatives

ω-phosphonic acid, derivative

ethylendiphosphate acid, derivative

etieth (taucus) and diethyl diacetic acid,

monoamine complexes, in large groups are replaced by

Physical, or mixture.

17. Disinfectant πο π. 14 or 15

ο τ и а а с

in a well-known interconnected metal containing

The domestic ligand, which possesses a good source of foreign food, is

The desired ligand was used in one of the following amino acids: isoleucine,

phenylalanine, lycine, lysine, methionine, tropionine, triptypane, valine, alanine,

glycine, arginine, histidine, or a mixture thereof.

18. Disinfectant, πο π. 14, 40

different, that

in the form of a commercially available complex metal compound containing

The use of a ligand that is commercially available is based on the use of natural resources.

Chlorine glycine complex of copper.

19. Disinfectant, πο π.14,

different, that

in the form of a commercially available complex metal compound containing

ethylenediaminetetoacetic copper complex.

20. Disinfectant, πο π.14,

different, that

in the form of a commercially available complex metal compound containing

Ethylenediaminetetzate complex of zinc.

21. Disinfectant, any of π.14 - 20,

different, that 41

in the quality of the original active substance is used

cetylpyridinium halides.

22. Disinfectant, for any of p. 14 - 20,

different, that

in the quality of the original active substance is used

cetyl methyl halides.

23. Disinfectant, including virgin

a portable active substance, a complex and a device,

different, that

in the form of a chelate complex, a chelate complex is used

metal compound containing a basic ligand possessing

food and drink,

and in the quality of the distributor use distilled water and

aliphatic syrup (Сι - С ₈ ) at the following ratio of mass%:

The industrial compound of metals, containing a ligand that is commercially available, possesses 1–30 of the foreign substance -

INGENERAL ACTIVE ACTIVE MATTER - 0.1-15

Pulmonary syndrome (Сι - С ₈ ) - 0.5 - 95

Distilled Water - Other 42

24. Disinfectant πο π. 23,

ο τ и а а с,,

Preferred Integrated Metal Compound Containing

selenium, platinum, gold, titanium, tin or on the basis of their alloys.

25. Disinfectant, πο π. 23 or 24,

ο τ и а а с,,

in a well-known interconnected metal containing

The domestic ligand, which possesses a good source of foreign food, is

The desired ligand is used as one of the bi- or multiple ligands,

Such as anionic acid, amino diacetic acid and

nitrate acetic acid, carbon-substituted (in α-position κ

large group) derivative iminus dius and nitrous impurities

Acid with various residues of amino acids without

amine acid, alkylene diamine polyoxy acids, carbon

substituted (in the α-position of the large group) π derivatives 43

polyalkylene-poliaminopolyacetic acid with various residues

Amino Acid Fragments without an Amino Acid Group, Derivatives

ω-phosphonic acid and ethylendiphosphate acid,

Derivatives of ethylene (tiususny) and dietetiusyusny

Acids, Monoamine Compounds, In Large Groups

replaced by phosphonic, or mixtures thereof.

26. Disinfecting agent πpo 23 or 25,

different, that

in a well-known interconnected metal containing

The domestic ligand, which possesses a good source of foreign food, is

The desired ligand was used in one of the following amino acids: isoleucine,

glycine, arginine, histidine, or a mixture thereof.

27. Disinfectant πο π.23,

different, that

in the form of a commercially available complex metal compound containing

Chlorine glycine complex of copper. 44

28. Disinfectant, πο π.23,

different, that

in the form of a commercially available complex metal compound containing

ethylenediaminetetoacetic copper complex.

29. Disinfectant πο π.23,

different, that

in the form of a commercially available complex metal compound containing

Ethylenediaminetetzate complex of zinc.

30. Disinfectant, for any of π.23 - 29,

different, that

in the quality of the original active substance is used

cetylpyridinium halides.

31. Disinfectant, any of π.23 - 29,

different, that 45

in the quality of the original active substance is used

cetyl methyl halides.