WO2002086443A2 - Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer - Google Patents

Abstract

Described herein are methods and compositions that can be used for diagnosis and treatment of lung cancer and similar pathologies. Also described herein are methods that can be used to identify modulators of lung cancer and similar pathologies.

Description

METHODS OF DIAGNOSIS OF LUNG CANCER, COMPOSITIONS AND METHODS OF SCREENING FOR MODULATORS OF LUNG CANCER

CROSS-REFERENCES TO RELATED APPLICATIONS

This application is related to USSN 60/284,770, filed April 18, 2001; USSN 60/290,492, filed May 10, 2001; USSN 60/334,370, filed November 29, 2001; USSN 60/339,245, filed November 9, 2001; USSN 60/350,666, filed November 13, 2001; and USSN 60/xxx,xxx, filed April 12, 2002 (Docket OMNI-002P); each of which is incorporated herein by reference in its entirety.

FIELD OF THE INVENTION The invention relates to the identification of nucleic acid and protein expression profiles and nucleic acids, products, and antibodies thereto that are involved in lung cancer; and to the use of such expression profiles and compositions in diagnosis and therapy of lung cancer. The invention further relates to methods for identifying and using agents and/or targets that inhibit lung cancer or related conditions.

BACKGROUND OF THE INVENTION

Lung cancer is the second most commonly occurring cancer in the United States and is the leading cause of cancer-related death. It is estimated that there are over 160,000 new cases of lung cancer in the United States every year. Of those who are diagnosed with lung cancer, 86 percent will die within five years. Lung cancer is the most common visceral cancer in men and accounts for nearly one third of all cancer deaths in both men and women. In fact, lung cancer accounts for 7% of all deaths, due to any cause, in both men and women.

Smoking is the primary cause of lung cancer, with more than 80% of lung cancers resulting from smoking. About 400 to 500 separate gaseous substances are present in the smoke of a non-filter cigarette. The most noteworthy substances include nitrogen oxides, hydrogen cyanide, formaldehyde, benzene, and toluene. The particles present in cigarette smoke contain at least 3,500 individual compounds such as nicotine, tobacco alkaloids (nornicotine, anatabine, anabasine), polycyclic aromatic hydrocarbons (e.g., benzo(a)pyrene, B(a)P), naphthalenes, aromatic amines, phenols, and tobacco-specific nitrosamines. Tobacco-specific nitrosamines are formed during tobacco curing and processing, and are suspected of causing lung cancer in humans. In rodent studies, regardless ofthe where or how it is applied, the tobacco-specific nitrosamine known as NNK produces lung adenomas and lung adenocarcinomas. The tobacco-specific nitrosamine known as NNAL also produces lung adenocarcinomas in rodents.

Many ofthe chemicals found in cigarette smoke also affect the nonsmoker inhaling "secondhand" or sidestream smoke. Indeed, the smoke inhaled by non-smokers has a chemical composition similar to the smoke inhaled by smokers, but, importantly, the concentrations ofthe carcinogenic tobacco-specific nitrosamines are present in higher concentrations in second hand smoke. For this and other reasons, "passive smoking" is an important cause of lung cancer, causing as many as 3,000 lung cancer deaths in nonsmokers each year.

In addition to smoking, other factors thought to be causes of lung cancer include on- the-job exposure to carcinogens such as asbestos and uranium, exposure to chemical hazards such as radon, polycyclic aromatic hydrocarbons, chromium, nickel, and inorganic arsenic, genetic factors, and diet.

Histological classification of various lung cancers define the types of cancer that begin in the lung. See, e.g., Travis, et al. (1999) Histological Typing of Lung and Pleural Tumours (International Histological Classification of Tumours, No 1. Four major cell types make up more than 88% of all primary lung neoplasms. These are: squamous or epidermoid carcinoma, small cell (also called oat cell) carcinoma, adenocarcinoma, and large cell (also called large cell anaplastic) carcinoma. The remainder include undifferentiated carcinomas, carcinoids, bronchial gland tumors, and other rarer types. The various cell types have different natural histories and responses to therapy, and, thus, a correct histologic diagnosis is the first step of effective treatment.

Small cell lung cancer (SCLC) accounts for 18-25% of all lung cancers, and occurs less frequently than non-small cell lung cancers, and generally spread to distant organs more rapidly than non-small cell lung cancer. In general, at the time of presentation small cell lung cancers have already spread beyond the beyond the bounds where surgery and curative intent can be undertaken. Hoever, if identified early enough, these cancers are often responsive to chemotherapy and thoracic radiation treatment.

Non-small cell lung cancers (NSCLC) are the more frequently occurring form of lung cancer. They comprise squamous cell carcinoma, adenocarcinoma, and large cell carcinoma and account for more than 75% of all lung cancers. Non-small cell tumors that are localized at the time of presentation can sometimes be cured with surgery and/or radiotherapy, but usually are not identified until significant metastasis has occurred, which are typically not very responsive to surgical, chemotherapy, or radiation treatment.. The screening of asymptomatic persons at high risk for lung cancer has often proven ineffective. In general, only 5 to 15 percent of lung cancer patients have their disease detected while they are asymptomatic. Of course, early detection and treatment are critical factors in the fight against lung cancer. The average survival rate is 49% for those whose cancer is detected early, before the cancer has spread from the lung. Lung cancer often spreads outside ofthe lung, and it may have spread to the bones or brain by the time it is diagnosed. While the prognosis may be better for lung cancers that are detected early, because ofthe lack ofv effective curative treatments, early detection does not necessarily alter the total death rate from lung cancer.

Thus, methods for diagnosis and prognosis of lung cancer and effective treatment of lung cancer would be desirable. Accordingly, provided herein are methods that can be used in diagnosis and prognosis of lung cancer. Further provided are methods that can be used to screen candidate therapeutic agents for the ability to modulate, e.g., treat, lung cancer. Additionally, provided herein are molecular targets and compositions for therapeutic intervention in lung disease and other metastatic cancers.

SUMMARY OF THE INVENTION The present invention provides nucleotide sequences of genes that are up- and downregulated in lung cancer cells. Such genes are useful for diagnostic purposes, and also as targets for screening for therapeutic compounds that modulate lung cancer, such as antibodies. The methods of detecting nucleic acids ofthe invention or their encoded proteins can be used for a number of purposes. Examples include early detection of lung cancers, monitoring and early detection of relapse following treatment of lung cancers, monitoring response to therapy of lung cancers, determining prognosis of lung cancers, directing therapy of lung cancers, selecting patients for postoperative chemotherapy or radiation therapy, selecting therapy, determining tumor prognosis, treatment, or response to treatment, and early detection ofprecancerous lesions ofthe lung. Examples of benign or precancerous lesions include: atelectasis, emphysema, brochitis, chronic obstructive pulmonary disease, fibrosis, hypersensitivity pneumonitis (HP), interstitial pulmonary fibrosis (IPF), asthma, and bronchiectasis. Other aspects ofthe invention will become apparent to the skilled artisan by the following description ofthe invention.

In one aspect, the present invention provides a method of detecting a lung cancer- associated transcript in a cell from a patient, the method comprising contacting a biological sample from the patient with a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1 A-16. Alternatively, the sample may be contacted with a specific binding reagent, e.g., antibody.

In one embodiment, the polynucleotide selectively hybridizes to a sequence at least 95% identical to a sequence as shown in Tables 1A-16. In another embodiment, the polynucleotide comprises a sequence as shown in Tables 1A-16.

In one embodiment, the biological sample is a tissue sample, or a body fluid. In another embodiment, the biological sample comprises isolated nucleic acids, e.g., mRNA.

In one embodiment, the polynucleotide is labeled, e.g., with a fluorescent label. In one embodiment, the polynucleotide is immobilized on a solid surface. In one embodiment, the patient is undergoing a therapeutic regimen to treat lung cancer. In another embodiment, the patient is suspected of having lung cancer. In one embodiment, the patient is a primate, e.g., a human.

In one embodiment, the method further comprises the step of amplifying nucleic acids before the step of contacting the biological sample with the polynucleotide. In another aspect, the present invention provides a method of monitoring the efficacy of a therapeutic treatment of lung cancer, the method comprising the steps of: (i) providing a biological sample from a patient undergoing the therapeutic treatment; and (ii) determining the level of a lung cancer-associated transcript in the biological sample by contacting the biological sample with a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1 A-16, thereby monitoring the efficacy ofthe therapy. Or the sample may be evaluated for protein, e.g., contacting the sample with an antibody.

In one embodiment, the method further comprises the step of: (iii) comparing the level ofthe lung cancer-associated transcript to a level ofthe lung cancer-associated transcript in a biological sample from the patient prior to, or earlier in, the therapeutic treatment. Or the sample may be evalated for comparison of protein.

In another aspect, the present invention provides a method of monitoring the efficacy of a therapeutic treatment of lung cancer, the method comprising the steps of: (i) providing a biological sample from a patient undergoing the therapeutic treatment; and (ii) determining the level of a lung cancer-associated antibody in the biological sample by contacting the biological sample with a polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1A-16, wherein the polypeptide specifically binds to the lung cancer-associated antibody, thereby monitoring the efficacy ofthe therapy.

In one embodiment, the method further comprises the step of: (iii) comparing the level ofthe lung cancer-associated antibody to a level ofthe lung cancer-associated antibody in a biological sample from the patient prior to, or earlier in, the therapeutic treatment. In another aspect, the present invention provides a method of monitoring the efficacy of a therapeutic treatment of lung cancer, the method comprising the steps of: (i) providing a biological sample from a patient undergoing the therapeutic treatment; and (ii) determining the level of a lung cancer-associated polypeptide in the biological sample by contacting the biological sample with an antibody, wherein the antibody specifically binds to a polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1 A-16, thereby monitoring the efficacy ofthe therapy. In one embodiment, the method further comprises the step of: (iii) comparing the level ofthe lung cancer-associated polypeptide to a level ofthe lung cancer-associated polypeptide in a biological sample from the patient prior to, or earlier in, the therapeutic treatment. In one aspect, the present invention provides an isolated nucleic acid molecule consisting of a polynucleotide sequence as shown in Tables 1A-16. In one embodiment, an expression vector or cell comprises the isolated nucleic acid. In one aspect, the present invention provides an isolated polypeptide which is encoded by a nucleic acid molecule having polynucleotide sequence as shown in Tables 1 A-16. In another aspect, the present invention provides an antibody that specifically binds to an isolated polypeptide which is encoded by a nucleic acid molecule having polynucleotide sequence as shown in Tables 1 A-16. In one embodiment, the antibody is conjugated to an effector component, e.g., a fluorescent label, a radioisotope or a cytotoxic chemical. In one embodiment, the antibody is an antibody fragment. In another embodiment, the antibody is humanized.

In one aspect, the present invention provides a method of detecting lung cancer in a a patient, the method comprising contacting a biological sample from the patient with an antibody or protein as described herein. In another aspect, the present invention provides a method of detecting antibodies specific to a lung cancer gene in a patient, the method comprising contacting a biological sample from the patient with a polypeptide encoded by a nucleic acid comprises a sequence from Tables 1A-16. In another aspect, the present invention provides a method for identifying a compound that modulates a lung cancer-associated polypeptide, the method comprising the steps of: (i) contacting the compound with a lung cancer-associated polypeptide, the polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1 A-16; and (ii) determining the functional effect ofthe compound upon the polypeptide.

In one embodiment, the functional effect is a physical effect, an enzymatic effect, or a chemical effect. In one embodiment, the polypeptide is expressed in a eukaryotic host cell or cell membrane. In another embodiment, the polypeptide is recombinant. In one embodiment, the functional effect is determined by measuring ligand binding to the polypeptide.

In another aspect, the present invention provides a method of inhibiting proliferation or another critical process of a lung cancer-associated cell to treat lung cancer in a patient, the method comprising the step of administering to the subject a therapeutically effective amount of a compound identified as described herein. In one embodiment, the compound is an antibody.

In another aspect, the present invention provides a drug screening assay comprising the steps of: (i) administering a test compound to a mammal having lung cancer or a cell isolated therefrom; (ii) comparing the level of gene expression of a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1 A- 16 in a treated cell or mammal with the level of gene expression ofthe polynucleotide in a control cell or mammal, wherein a test compound that modulates the level of expression of the polynucleotide is a candidate for the treatment of lung cancer.

In one embodiment, the control is a mammal with lung cancer or a cell therefrom that has not been treated with the test compound. In another embodiment, the control is a normal cell or mammal, or a non-malignant lung disease.

In another aspect, the present invention provides a method for treating a mammal having lung cancer comprising administering a compound identified by the assay described herein. In another aspect, the present invention provides a pharmaceutical composition for treating a mammal having lung cancer, the composition comprising a compound identified by the assay described herein and a physiologically acceptable excipient.

DETAILED DESCRIPTION OF THE INVENTION

In accordance with the objects outlined above, the present invention provides novel methods for diagnosis and treatment of lung disease or cancer, as well as methods for screening for compositions which modulate lung cancer. "Treatment, monitoring, detection or modulation of lung disease or cancer" includes treatment, monitoring, detection, or modulation of lung disease in those patients who have lung disease (whether malignant or non-malignant, e.g., emphysema, bronchitis, or fibrosis) as well as patients with lung cancers in which gene expression from a gene in Tables 1 A- 16 is increased or decreased, indicating that the subject is more likely to have disease. In particular, while these targets are identified primarily from lung cancer samples, these same targets are likely to be similarly found in analyses of other medical conditions. These other conditions may result from similar pathological processes which affect similar tissues, e.g., lung cancer, small cell lung carcinoma (oat cell carcinoma), non-small cell carcinomas (e.g., squamous cell carcinoma, adenocarcinoma, large cell lung carcinoma, carcinoid, granulomatous), fibrosis (idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP), interstitial pneumonitis, nonspecific idiopathic pneumonitis (NSIP)), chronic obstructive pulmonary disease (COPD, e.g., emphysema, chronic bronchitis), asthma, bronchiectasis, and esophageal cancer. See, e.g., the NCI webpage and USSN 60/347,349 and USSN 60/xxx,xxx (docket LFBR-001-1P, filed March 29, 2002), each of which is incorporated herein by reference. The treatment may be of lung cancer or related condition itself, or treatment of metastasis. In particular, identification of markers selectively expressed on these cancers allows for use of that expression in diagnostic, prognostic, or therapeutic methods. As such, the invention defines various compositions, e.g., nucleic acids, polypeptides, antibodies, and small molecule agonists/antagonists, which will be useful to selectively identify those markers. For example, therapeutic methods may take the form of protein therapeutics which use the marker expression for selective localization or modulation of function (for those markers which have a causative disease effect), for vaccines, identification of binding partners, or antagonism, e.g., using antisense or RNAi. The markers may be useful for molecular characterization of subsets of lung diseases, which subsets may actually require very different treatments. Moreover, the markers may also be important in related diseases to the specific cancers, e.g., which affect similar tissues in non-malignant diseases, or have similar mechanisms of induction/maintenance. Metastatic processes or characteristics may also be targeted. Diagnostic and prognostic uses are made available, e.g., to subset related but distinct diseases, or to determine treatment strategy. The detection methods may be based upon nucleic acid, e.g., PCR or hybridization techniques, or protein, e.g., ELISA, imaging, IHC, etc. The diagnosis may be qualitative or quantitative, and may detect increases or decreases in expression levels.

Tables 1A-16 provide unigene cluster identification numbers for the nucleotide sequence of genes that exhibit increased or decreased expression in lung cancer samples. The tables also provide an exemplar accession number that provides a nucleotide sequence that is part ofthe unigene cluster. In Table IA, genes marked as "target 1" or "target 2" are particularly useful as therapeutic targets. Genes marked as "target 3" are particularly useful as diagnostic markers. Genes marked as "chron" are upregulated in chronically diseased lung (e.g., emphysema, bronchitis, fibrosis) relative to lung tumors and normal tissue. In certain analyses, the ratio for the "chron" category was determined using the 70th percentile of chronically diseases lung samples divided by the 90th percentile of normal lung samples. The ratio for the targets was determined using the 70th percentile of lung tumor samples divided by the 90th percentile of normal lung samples.

Definitions

The term "lung cancer protein" or "lung cancer polynucleotide" or "lung cancer- associated transcript" refers to nucleic acid and polypeptide polymorphic variants, alleles, mutants, and interspecies homologs that: (1) have a nucleotide sequence that has greater than about 60% nucleotide sequence identity, 65%, 70%, 75%, 80%, 85%, 90%, preferably 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% or greater nucleotide sequence identity, preferably over a region of over a region of at least about 25, 50, 100, 200, 500, 1000, or more nucleotides, to a nucleotide sequence of or associated with a unigene cluster of Tables 1A-16; (2) bind to antibodies, e.g., polyclonal antibodies, raised against an immunogen comprising an amino acid sequence encoded by a nucleotide sequence of or associated with a unigene cluster of Tables 1A-16, and conservatively modified variants thereof; (3) specifically hybridize under stringent hybridization conditions to a nucleic acid sequence, or the complement thereof of Tables 1A-16 and conservatively modified variants thereof; or (4) have an amino acid sequence that has greater than about 60% amino acid sequence identity, 65%, 70%, 75%, 80%, 85%, 90%, preferably 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% or greater amino sequence identity, preferably over a region of over a region of at least about 25, 50, 100, 200, 500, 1000, or more amino acid, to an amino acid sequence encoded by a nucleotide sequence of or associated with a unigene cluster of Tables 1A-16. A polynucleotide or polypeptide sequence is typically from a mammal including, but not limited to, primate, e.g., human; rodent, e.g., rat, mouse, hamster; cow, pig, horse, sheep, or other mammal. A "lung cancer polypeptide" and a "lung cancer polynucleotide," include both naturally occurring or recombinant forms. A "full length" lung cancer protein or nucleic acid refers to a lung cancer polypeptide or polynucleotide sequence, or a variant thereof, that contains the elements normally contained in one or more naturally occurring, wild type lung cancer polynucleotide or polypeptide sequences. The "full length" may be prior to, or after, various stages of post- translational processing or splicing, including alternative splicing. "Biological sample" as used herein is a sample of biological tissue or fluid that contains nucleic acids or polypeptides, e.g., of a lung cancer protein, polynucleotide, or transcript. Such samples include, but are not limited to, tissue isolated from primates, e.g., humans, or rodents, e.g., mice, and rats. Biological samples may also include sections of tissues such as biopsy and autopsy samples, frozen sections taken for histologic purposes, archival materials, blood, plasma, serum, sputum, stool, tears, mucus, hair, skin, etc. Biological samples also include explants and primary and/or transformed cell cultures derived from patient tissues. A biological sample is typically obtained from a eukaryotic organism, most preferably a mammal such as a primate, e.g., chimpanzee or human; cow; dog; cat; a rodent, e.g., guinea pig, rat, mouse; rabbit; or other mammal; or a bird; reptile; fish. Livestock and domestic animals are of interest.

"Providing a biological sample" means to obtain a biological sample for use in methods described in this invention. Most often, this will be done by removing a sample of cells from an animal, but can also be accomplished by using previously isolated cells (e.g., isolated by another person, at another time, and/or for another purpose), or by performing the methods ofthe invention in vivo. Archival tissues or materials, having treatment or outcome history, will be particularly useful.

The terms "identical" or percent "identity," in the context of two or more nucleic acids or polypeptide sequences, refer to two or more sequences or subsequences that are the same or have a specified percentage of amino acid residues or nucleotides that are the same (e.g., about 60% identity, preferably 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or higher identity over a specified region, when compared and aligned for maximum correspondence over a comparison window or designated region) as measured using, e.g., a BLAST or BLAST 2.0 sequence comparison algorithms with default parameters described below, or by manual alignment and visual inspection (see, e.g., NCBI web site http://www.ncbi.nlm.nih.gov/BLAST/ or the like). Such sequences are then said to be "substantially identical." This definition also refers to, or may be applied to, the complement of a test sequence. The definition also includes sequences that have deletions and/or insertions, substitutions, and naturally occurring, e.g., polymorphic or allelic variants, and man-made variants. As described below, the preferred algorithms can account for gaps and the like. Preferably, identity exists over a region that is at least about 25 amino acids or nucleotides in length, or more preferably over a region that is 50-100 amino acids or nucleotides in length. For sequence comparison, typically one sequence acts as a reference sequence, to which test sequences are compared. When using a sequence comparison algorithm, test and reference sequences are entered into a computer, subsequence coordinates are designated, if necessary, and sequence algorithm program parameters are designated. Preferably, default program parameters can be used, or alternative parameters can be designated. The sequence comparison algorithm then calculates the percent sequence identities for the test sequences relative to the reference sequence, based on the program parameters.

A "comparison window", as used herein, includes reference to a segment of contiguous positions selected from the group consisting typically of from 20 to 600, usually about 50 to about 200, more usually about 100 to about 150 in which a sequence may be compared to a reference sequence of the same number of contiguous positions after the two sequences are optimally aligned. Methods of alignment of sequences for comparison are well-known in the art. Optimal alignment of sequences for comparison can be conducted, e.g., by the local homology algorithm of Smith and Waterman (1981) Adv. Appl. Math. 2:482, by the homology alignment algorithm of Needleman and Wunsch (1970) J. Mol. Biol. 48:443, by the search for similarity method of Pearson and Lipman (1988) Proc. NatT. Acad. Sci. USA 85:2444, by computerized implementations of these algorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, 575 Science Dr., Madison, Wl), or by manual alignment and visual inspection (see, e.g., Ausubel, et al. (eds. 1995 and supplements) Current Protocols in Molecular Biology.

Preferred examples of algorithms that are suitable for determining percent sequence identity and sequence similarity include the BLAST and BLAST 2.0 algorithms, which are described in Altschul, et al. (1977) Nuc. Acids Res. 25:3389-3402 and Altschul, et al. (1990) J. Mol. Biol. 215:403-410. BLAST and BLAST 2.0 are used, with the parameters described herein, to determine percent sequence identity for the nucleic acids and proteins ofthe invention. Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov/). This algorithm involves first identifying high scoring sequence pairs (HSPs) by identifying short words of length W in the query sequence, which either match or satisfy some positive- valued threshold score T when aligned with a word ofthe same length in a database sequence. T is referred to as the neighborhood word score threshold (Altschul, et al., supra). These initial neighborhood word hits act as seeds for initiating searches to find longer HSPs containing them. The word hits are extended in both directions along each sequence for as far as the cumulative alignment score can be increased. Cumulative scores are calculated using, e.g., for nucleotide sequences, the parameters M (reward score for a pair of matching residues; always > 0) and N (penalty score for mismatching residues; always < 0). For amino acid sequences, a scoring matrix is used to calculate the cumulative score. Extension ofthe word hits in each direction are halted when: the cumulative alignment score falls off by the quantity X from its maximum achieved value; the cumulative score goes to zero or below, due to the accumulation of one or more negative-scoring residue alignments; or the end of either sequence is reached. The BLAST algorithm parameters W, T, and X determine the sensitivity and speed ofthe alignment. The BLASTN program (for nucleotide sequences) uses as defaults a wordlength (W) of 11, an expectation (E) of 10, M=5, N=-4 and a comparison of both strands. For amino acid sequences, the BLASTP program uses as defaults a wordlength of 3, and expectation (E) of 10, and the BLOSUM62 scoring matrix (see Henikoff and Henikoff (1989) Proc. Natl. Acad. Sci. USA 89:10915) alignments (B) of 50, expectation (E) of 10, M=5, N=-4, and a comparison of both strands. The BLAST algorithm also performs a statistical analysis ofthe similarity between two sequences (see, e.g., Karlin and Altschul (1993) Proc. NatT. Acad. Sci. USA 90:5873- 5787). One measure of similarity provided by the BLAST algorithm is the smallest sum probability (P(N)), which provides an indication ofthe probability by which a match between two nucleotide or amino acid sequences would occur by chance. For example, a nucleic acid is considered similar to a reference sequence if the smallest sum probability in a comparison ofthe test nucleic acid to the reference nucleic acid is less than about 0.2, more preferably less than about 0.01, and most preferably less than about 0.001. Log values may be negative large numbers, e.g., 5, 10, 20, 30, 40, 40, 70, 90, 110, 150, 170, etc.

An indication that two nucleic acid sequences are substantially identical is that the polypeptide encoded by the first nucleic acid is immunologically cross reactive with the antibodies raised against the polypeptide encoded by the second nucleic acid. Thus, a polypeptide is typically substantially identical to a second polypeptide, e.g., where the two peptides differ only by conservative substitutions. Another indication that two nucleic acid sequences are substantially identical is that the two molecules or their complements hybridize to each other under stringent conditions. Yet another indication that two nucleic acid sequences are substantially identical is that the same primers can be used to amplify the sequences. A "host cell" is a naturally occurring cell or a transformed cell that contains an expression vector and supports the replication or expression ofthe expression vector. Host cells may be cultured cells, explants, cells in vivo, and the like. Host cells may be prokaryotic cells such as E. coli, or eukaryotic cells such as yeast, insect, amphibian, or mammalian cells such as CHO, HeLa, and the like (see, e.g., the American Type Culture Collection catalog or web site, www.atcc.org).

The terms "isolated," "purified," or "biologically pure" refer to material that is substantially or essentially free from components that normally accompany it as found in its native state. Purity and homogeneity are typically determined using analytical chemistry techniques such as polyacrylamide gel electrophoresis or high performance liquid chromatography. A protein or nucleic acid that is the predominant species present in a preparation is substantially purified. In particular, an isolated nucleic acid is separated from some open reading frames that naturally flank the gene and encode proteins other than protein encoded by the gene. The term "purified" in some embodiments denotes that a nucleic acid or protein gives rise to essentially one band in an electrophoretic gel. Preferably, it means that the nucleic acid or protein is at least about 85% pure, more preferably at least 95% pure, and most preferably at least 99% pure. "Purify" or "purification" in other embodiments means removing at least one contaminant or component from the composition to be purified. In this sense, purification does not require that the purified compound be homogeneous, e.g., 100% pure.

The terms "polypeptide," "peptide" and "protein" are used interchangeably herein to refer to a polymer of amino acid residues. The terms apply to amino acid polymers in which one or more amino acid residue is an artificial chemical mimetic of a corresponding naturally occurring amino acid, as well as to naturally occurring amino acid polymers, those containing modified residues, and non-naturally occurring amino acid polymer.

The term "amino acid" refers to naturally occurring and synthetic amino acids, as well as amino acid analogs and amino acid mimetics that function similarly to the naturally occurring amino acids. Naturally occurring amino acids are those encoded by the genetic code, as well as those amino acids that are later modified, e.g., hydroxyproline, γ- carboxyglutamate, and O-phosphoserine. Amino acid analogs refer to compounds that have the same basic chemical structure as a naturally occurring amino acid, e.g., an α carbon that is bound to a hydrogen, a carboxyl group, an amino group, and an R group, e.g., homoserine, norleucine, methionine sulfoxide, methionine methyl sulfonium. Such analogs may have modified R groups (e.g., norleucine) or modified peptide backbones, but retain some basic chemical structure as a naturally occurring amino acid. Amino acid mimetics refer to chemical compounds that have a structure that is different from the general chemical structure of an amino acid, but that function similarly to another amino acid. Amino acids may be referred to herein by either their commonly known three letter symbols or by the one-letter symbols recommended by the IUPAC-IUB Biochemical Nomenclature Commission. Nucleotides, likewise, may be referred to by their commonly accepted single-letter codes.

"Conservatively modified variants" applies to both amino acid and nucleic acid sequences. With respect to particular nucleic acid sequences, conservatively modified variants refers to those nucleic acids which encode identical or essentially identical amino acid sequences, or where the nucleic acid does not encode an amino acid sequence, to essentially identical or associated, e.g., naturally contiguous, sequences. Because ofthe degeneracy ofthe genetic code, a large number of functionally identical nucleic acids encode most proteins. For instance, the codons GCA, GCC, GCG, and GCU each encode the amino acid alanine. Thus, at each position where an alanine is specified by a codon, the codon can be altered to another ofthe corresponding codons described without altering the encoded polypeptide. Such nucleic acid variations are "silent variations," which are one species of conservatively modified variations. Every nucleic acid sequence herein which encodes a polypeptide also describes silent variations ofthe nucleic acid. In certain contexts each codon in a nucleic acid (except AUG, which is ordinarily the only codon for methionine, and TGG, which is ordinarily the only codon for tryptophan) can be modified to yield a functionally similar molecule. Accordingly, a silent variation of a nucleic acid which encodes a polypeptide is implicit in a described sequence with respect to the expression product, but not necessarily with respect to actual probe sequences.

As to amino acid sequences, one of skill will recognize that individual substitutions, deletions or additions to a nucleic acid, peptide, polypeptide, or protein sequence which alters, adds or deletes a single amino acid or a small percentage of amino acids in the encoded sequence is a "conservatively modified variant" where the alteration results in the substitution of an amino acid with a chemically similar amino acid. Conservative substitution tables providing functionally similar amino acids are well known in the art. Such conservatively modified variants are in addition to and do not exclude polymorphic variants, interspecies homologs, and alleles ofthe invention. Typically conservative substitutions include for one another: 1) Alanine (A), Glycine (G); 2) Aspartic acid (D), Glutamic acid (E); 3) Asparagine (N), Glutamine (Q); 4) Arginine (R), Lysine (K); 5) Isoleucine (I), Leucine (L), Methionine (M), Valine (V); 6) Phenylalanine (F), Tyrosine (Y), Tryptophan (W); 7) Serine (S), Threonine (T); and 8) Cysteine (C), Methionine (M) (see, e.g., Creighton, Proteins (1984)). Macromolecular structures such as polypeptide structures can be described in terms of various levels of organization. For a general discussion of this organization, see, e.g., Alberts, et al. (1994) Molecular Biology ofthe Cell (3^rd ed.) and Cantor and Schimmel (1980) Biophysical Chemistry Part I: The Conformation of Biological Macromolecules. "Primary structure" refers to the amino acid sequence of a particular peptide. "Secondary structure" refers to locally ordered, three dimensional structures within a polypeptide. These structures are commonly known as domains. Domains are portions of a polypeptide that often form a compact unit ofthe polypeptide and are typically 25 to approximately 500 amino acids long. Typical domains are made up of sections of lesser organization such as stretches of β-sheet and α-helices. "Tertiary structure" refers to the complete three dimensional structure of a polypeptide monomer. "Quaternary structure" refers to the three dimensional structure formed, usually by the noncovalent association of independent tertiary units. Anisotropic terms are also known as energy terms. "Nucleic acid" or "oligonucleotide" or "polynucleotide" or grammatical equivalents used herein means at least two nucleotides covalently linked together. Oligonucleotides are typically from about 5, 6, 7, 8, 9, 10, 12, 15, 25, 30, 40, 50 or more nucleotides in length, up to about 100 nucleotides in length. Nucleic acids and polynucleotides are a polymers of any length, including longer lengths, e.g., 200, 300, 500, 1000, 2000, 3000, 5000, 7000, 10,000, etc. A nucleic acid ofthe present invention will generally contain phosphodiester bonds, although in some cases, nucleic acid analogs are included that may have at least one different linkage, e.g., phosphoramidate, phosphorothioate, phosphorodithioate, or O- methylphophoroamidite linkages (see Eckstein (1992) Oligonucleotides and Analogues: A Practical Approach Oxford University Press); and peptide nucleic acid backbones and linkages. Other analog nucleic acids include those with positive backbones; non-ionic backbones, and non-ribose backbones, including those described in U.S. Patent Nos. 5,235,033 and 5,034,506, and Chapters 6 and 7, in Sanghui and Cook, eds. Carbohydrate Modifications in Antisense Research. ASC Symposium Series 580. Nucleic acids containing one or more carbocyclic sugars are also included within one definition of nucleic acids.

Modifications ofthe ribose-phosphate backbone may be done for a variety of reasons, e.g., to increase the stability and half-life of such molecules in physiological environments or as probes on a biochip. Mixtures of naturally occurring nucleic acids and analogs can be made; alternatively, mixtures of different nucleic acid analogs, and mixtures of naturally occurring nucleic acids and analogs may be made.

Particularly preferred are peptide nucleic acids (PNA) which includes peptide nucleic acid analogs. These backbones are substantially non-ionic under neutral conditions, in contrast to the highly charged phosphodiester backbone of naturally occurring nucleic acids. This results in two advantages. First, the PNA backbone exhibits improved hybridization kinetics. PNAs have larger changes in the melting temperature (T_m) for mismatched versus perfectly matched basepairs. DNA and RNA typically exhibit a 2-4° C drop in T_m for an internal mismatch. With the non-ionic PNA backbone, the drop is closer to 7-9° C. Similarly, due to their non-ionic nature, hybridization ofthe bases attached to these backbones is relatively insensitive to salt concentration. In addition, PNAs are not degraded by cellular enzymes, and thus can be more stable.

The nucleic acids may be single stranded or double stranded, as specified, or contain portions of both double stranded or single stranded sequence. As will be appreciated by those in the art, the depiction of a single strand also defines the sequence ofthe complementary strand; thus the sequences described herein also provide the complement ofthe sequence. The nucleic acid may be DNA, both genomic and cDNA, RNA, or a hybrid, where the nucleic acid may contain combinations of deoxyribo- and ribo-nucleotides, and combinations of bases, including uracil, adenine, thymine, cytosine, guanine, inosine, xanthine hypoxanthine, isocytosine, isoguanine, etc. "Transcript" typically refers to a naturally occurring RNA, e.g., a pre-mRNA, hnRNA, or mRNA. As used herein, the term "nucleoside" includes nucleotides and nucleoside and nucleotide analogs, and modified nucleosides such as amino modified nucleosides. In addition, "nucleoside" includes non- naturally occurring analog structures. Thus, e.g., the individual units of a peptide nucleic acid, each containing a base, are referred to herein as a nucleoside.

A "label" or a "detectable moiety" is a composition detectable by spectroscopic, photochemical, biochemical, immunochemical, physiological, chemical, or other physical means. For example, useful labels include ³²P, fluorescent dyes, electron-dense reagents, enzymes (e.g., as commonly used in an ELISA), biotin, digoxigenin, or haptens and proteins or other entities which can be made detectable, e.g., by incorporating a radiolabel into the peptide or used to detect antibodies specifically reactive with the peptide. The labels may be incorporated into the cancer nucleic acids, proteins, and antibodies. Many methods known in the art for conjugating the antibody to the label may be employed, including those methods described by Hunter, et al. (1962) Nature 144:945; David, et al. (1974) Biochemistry 13:1014-1021; Pain, et al. (1981 J. Immunol. Meth.. 40:219-230: and Nygren (1982) I Histochem. and Cvtochem. 30:407-412.

An "effector" or "effector moiety" or "effector component" is a molecule that is bound (or linked, or conjugated), either covalently, through a linker or a chemical bond, or noncovalently, through ionic, van der Waals, electrostatic, or hydrogen bonds, to an antibody. The "effector" can be a variety of molecules including, e.g., detection moieties including radioactive compounds, fluorescent compounds, an enzyme or substrate, tags such as epitope tags, a toxin; activatable moieties, a chemotherapeutic agent; a lipase; an antibiotic; or a radioisotope emitting "hard" e.g., beta radiation.

A "labeled nucleic acid probe or oligonucleotide" is one that is bound, either covalently, through a linker or a chemical bond, or noncovalently, through ionic, van der Waals, electrostatic, or hydrogen bonds to a label such that the presence ofthe probe may be detected by detecting the presence ofthe label bound to the probe. Alternatively, method using high affinity interactions may achieve the same results where one of a pair of binding partners binds to the other, e.g., biotin, streptavidin.

As used herein a "nucleic acid probe or oligonucleotide" is a nucleic acid capable of binding to a target nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing, e.g., through hydrogen bond formation. As used herein, a probe may include natural (i.e., A, G, C, or T) or modified bases (7-deazaguanosine, inosine, etc.). In addition, the bases in a probe may be joined by a linkage other than a phosphodiester bond, preferably one that does not functionally interfere with hybridization. Thus, e.g., probes may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages. Probes may bind target sequences lacking complete complementarity with the probe sequence depending upon the stringency ofthe hybridization conditions. The probes are preferably directly labeled, e.g., with isotopes, chromophores, lumiphores, chromogens, or indirectly labeled, e.g., with biotin to which a streptavidin complex may later bind. By assaying for the presence or absence ofthe probe, one can detect the presence or absence ofthe select sequence or subsequence. Diagnosis or prognosis may be based at the genomic level, or at the level of RNA or protein expression.

The term "recombinant" when used with reference, e.g., to a cell, or nucleic acid, protein, or vector, indicates that the cell, nucleic acid, protein or vector, has been modified by the introduction of a heterologous nucleic acid or protein or the alteration of a native nucleic acid or protein, or that the cell is derived from a cell so modified. Thus, e.g., recombinant cells express genes that are not found within the native (non-recombinant) form ofthe cell or express native genes that are otherwise abnormally expressed, under expressed or not expressed at all. By the term "recombinant nucleic acid" herein is meant nucleic acid, originally formed in vitro, in general, by the manipulation of nucleic acid, e.g., using polymerases and endonucleases, in a form not normally found in nature. In this manner, operably linkage of different sequences is achieved. Thus an isolated nucleic acid, in a linear form, or an expression vector formed in vitro by ligating DNA molecules that are not normally joined, are both considered recombinant for the purposes of this invention. It is understood that once a recombinant nucleic acid is made and reinfroduced into a host cell or organism, it will replicate non-recombinantly, i.e., using the in vivo cellular machinery ofthe host cell rather than in vitro manipulations; however, such nucleic acids, once produced recombinanfiy, although subsequently replicated non-recombinantly, are still considered recombinant for the purposes ofthe invention. Similarly, a "recombinant protein" is a protein made using recombinant techniques, i.e., through the expression of a recombinant nucleic acid as depicted above.

The term "heterologous" when used with reference to portions of a nucleic acid indicates that the nucleic acid comprises two or more subsequences that are not normally found in the same relationship to each other in nature. For instance, the nucleic acid is typically recombinanfiy produced, having two or more sequences, e.g., from unrelated genes arranged to make a new functional nucleic acid, e.g., a promoter from one source and a coding region from another source. Similarly, a heterologous protein will often refer to two or more subsequences that are not found in the same relationship to each other in nature (e.g., a fusion protein).

A "promoter" is typically an array of nucleic acid control sequences that direct transcription of a nucleic acid. As used herein, a promoter includes necessary nucleic acid sequences near the start site of transcription, such as, in the case of a polymerase II type promoter, a TATA element. A promoter also optionally includes distal enhancer or repressor elements, which can be located as much as several thousand base pairs from the start site of transcription. A "constitutive" promoter is a promoter that is active under most environmental and developmental conditions. An "inducible" promoter is a promoter that is active under environmental or developmental regulation. The term "operably linked" refers to a functional linkage between a nucleic acid expression control sequence (such as a promoter, or array of transcription factor binding sites) and a second nucleic acid sequence, e.g., wherein the expression confrol sequence directs transcription ofthe nucleic acid corresponding to the second sequence.

An "expression vector" is a nucleic acid construct, generated recombinanfiy or synthetically, with a series of specified nucleic acid elements that permit transcription of a particular nucleic acid in a host cell. The expression vector can be part of a plasmid, virus, or nucleic acid fragment. Typically, the expression vector includes a nucleic acid to be transcribed in operable linkage to a promoter.

The phrase "selectively (or specifically) hybridizes to" refers to the binding, duplexing, or hybridizing of a molecule selectively to a particular nucleotide sequence under stringent hybridization conditions when that sequence is present in a complex mixture (e.g., total cellular or library DNA or RNA). The phrase "stringent hybridization conditions" refers to conditions under which a probe will hybridize to its target subsequence, typically in a complex mixture of nucleic acids, but to essentially no other sequences. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures. An extensive guide to the hybridization of nucleic acids is found in "Overview of principles of hybridization and the strategy of nucleic acid assays" in Tijssen (1993) Techniques in Biochemistry and Molecular Biology— Hybridization with Nucleic Probes (vol. 24) Elsevier. Generally, stringent conditions are selected to be about 5-10° C lower than the thermal melting point (T_m) for the specific sequence at a defined ionic strength pH. The T_m is the temperature (under defined ionic strength, pH, and nucleic concentration) at which 50% ofthe probes complementary to the target hybridize to the target sequence at equilibrium (as the target sequences are present in excess, at T_m, 50% ofthe probes are occupied at equilibrium). Stringent conditions will be those in which the salt concentration is less than about 1.0 M sodium ion, typically about 0.01 to 1.0 M sodium ion concentration (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C for short probes (e.g., 10 to 50 nucleotides) and at least about 60° C for long probes (e.g., greater than 50 nucleotides). Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide. For selective or specific hybridization, a positive signal is typically at least two times background, preferably 10 times background hybridization. Exemplary stringent hybridization conditions are often: 50% formamide, 5x SSC, and 1% SDS, incubating at 42° C, or, 5x SSC, 1% SDS, incubating at 65° C, with wash in 0.2x SSC, and 0.1%o SDS at 65° C. For PCR, a temperature of about 36° C is typical for low stringency amplification, although annealing temperatures may vary between about 32° C and 48° C depending on primer length. For high stringency PCR amplification, a temperature of about 62° C is typical, although high stringency annealing temperatures can range from about 50° C to about 65° C, depending on the primer length and specificity. Typical cycle conditions for both high and low stringency amplifications include a denaturation phase of 90° C - 95° C for 0.5 - 2 min., an annealing phase lasting 0.5 - 2 min., and an extension phase of about 72° C for 1 - 2 min. Protocols and guidelines for low and high stringency amplification reactions are provided, e.g., in Innis, et al.(1990) PCR Protocols. A Guide to Methods and Applications.

Nucleic acids that do not hybridize to each other under stringent conditions are still substantially identical if the polypeptides which they encode are substantially identical. This occurs, e.g., when a copy of a nucleic acid is created using the maximum codon degeneracy permitted by the genetic code. In such cases, the nucleic acids typically hybridize under moderately stringent hybridization conditions. Exemplary "moderately stringent hybridization conditions" include a hybridization in a buffer of 40% formamide, 1 M NaCl, 1% SDS at 37° C, and a wash in IX SSC at 45° C. A positive hybridization is at least twice background. Alternative hybridization and wash conditions can be utilized to provide conditions of similar stringency. Additional guidelines for determining hybridization parameters are provided in numerous reference, e.g., Ausubel, et al. (ed.) Current Protocols in Molecular Biology Lippincott. The phrase "functional effects" in the context of assays for testing compounds that modulate activity of a lung cancer protein includes the determination of a parameter that is indirectly or directly under the influence ofthe lung cancer protein or nucleic acid, e.g., a physiological, enzymatic, functional, physical, or chemical effect, such as the ability to decrease lung cancer. It includes ligand binding activity; cell viability, cell growth on soft agar; anchorage dependence; contact inhibition and density limitation of growth; cellular proliferation; cellular transformation; growth factor or serum dependence; tumor specific marker levels; invasiveness into Matrigel; tumor growth and metastasis in vivo; mRNA and protein expression in cells undergoing metastasis, and other characteristics of lung cancer cells. "Functional effects" include in vitro, in vivo, and ex vivo activities. By "determining the functional effect" is meant assaying for a compound that increases or decreases a parameter that is indirectly or directly under the influence of a lung cancer protein sequence, e.g., physiological, functional, enzymatic, physical, or chemical effects. Such functional effects can be measured by many means known to those skilled in the art, e.g., changes in spectroscopic characteristics (e.g., fluorescence, absorbance, refractive index), hydrodynamic (e.g., shape), chromatographic, or solubility properties for the protein, measuring inducible markers or transcriptional activation ofthe lung cancer protein; measuring binding activity or binding assays, e.g., binding to antibodies or other ligands, and measuring cellular proliferation. Determination ofthe functional effect of a compound on lung cancer can also be performed using lung cancer assays known to those of skill in the art such as an in vitro assays, e.g., cell growth on soft agar; anchorage dependence; contact inhibition and density limitation of growth; cellular proliferation; cellular transformation; growth factor or serum dependence; tumor specific marker levels; invasiveness into Matrigel; tumor growth and metastasis in vivo; mRNA and protein expression in cells undergoing metastasis, and other characteristics of lung cancer cells. The functional effects can be evaluated by many means known to those skilled in the art, e.g., microscopy for quantitative or qualitative measures of alterations in morphological features, measurement of changes in RNA or protein levels for lung cancer-associated sequences, measurement of RNA stability, identification of downstream or reporter gene expression (CAT, luciferase, β-gal, GFP, and the like), e.g., via chemiluminescence, fluorescence, colorimetric reactions, antibody binding, inducible markers, and ligand binding assays. "Inhibitors", "activators", and "modulators" of lung cancer polynucleotide and polypeptide sequences are used to refer to activating, inhibitory, or modulating molecules or compounds identified using in vitro and in vivo assays of lung cancer polynucleotide and polypeptide sequences. Inhibitors are compounds that, e.g., bind to, partially or totally block activity, decrease, prevent, delay activation, inactivate, desensitize, or down regulate the activity or expression of lung cancer proteins, e.g., antagonists. Antisense or inhibitory nucleic acids may seem to inhibit expression and subsequent function ofthe protein. "Activators" are compounds that increase, open, activate, facilitate, enhance activation, sensitize, agonize, or up regulate lung cancer protein activity. Inhibitors, activators, or modulators also include genetically modified versions of lung cancer proteins, e.g., versions with altered activity, as well as naturally occurring and synthetic ligands, antagonists, agonists, antibodies, small chemical molecules and the like. Such assays for inhibitors and activators include, e.g., expressing the lung cancer protein in vitro, in cells, or cell membranes, applying putative modulator compounds, and then determining the functional effects on activity, as described above. Activators and inhibitors of lung cancer can also be identified by incubating lung cancer cells with the test compound and determining increases or decreases in the expression of 1 or more lung cancer proteins, e.g., 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 40, 50 or more lung cancer proteins, such as lung cancer proteins encoded by the sequences set out in Tables 1A-16.

Samples or assays comprising lung cancer proteins that are treated with a potential activator, inhibitor, or modulator are compared to control samples without the inhibitor, activator, or modulator to examine the extent of inhibition. Control samples (untreated with inhibitors) are assigned a relative protein activity value of 100%. Inhibition of a polypeptide is achieved when the activity value relative to the control is about 80%, preferably 50%, more preferably 25-0%. Activation of a lung cancer polypeptide is achieved when the activity value relative to the control (untreated with activators) is 110%, more preferably 150%, more preferably 200-500% (i.e., two to five fold higher relative to the control), more preferably 1000-3000% higher.

The phrase "changes in cell growth" refers to any change in cell growth and proliferation characteristics in vitro or in vivo, such as cell viability, formation of foci, anchorage independence, semi-solid or soft agar growth, changes in contact inhibition and density limitation of growth, loss of growth factor or serum requirements, changes in cell morphology, gaining or losing immortalization, gaining or losing tumor specific markers, ability to form or suppress tumors when injected into suitable animal hosts, and/or immortalization ofthe cell. See, e.g., Freshney (1994) Culture of Animal Cells a Manual of Basic Technique pp. 231-241 (3^rd ed.).

"Tumor cell" refers to precancerous, cancerous, and normal cells in a tumor. "Cancer cells," "transformed" cells, or "transformation" in tissue culture, refers to spontaneous or induced phenotypic changes that do not necessarily involve the uptake of new genetic material. Although fransformation can arise from infection with a transforming virus and incorporation of new genomic DNA, or uptake of exogenous DNA, it can also arise spontaneously or following exposure to a carcinogen, thereby mutating an endogenous gene. Transformation is associated with phenotypic changes, such as immortalization of cells, aberrant growth control, nonmorphological changes, and/or malignancy (see, Freshney (1994) Culture of Animal Cells a Manual of Basic Technique (3^rd ed.)). "Antibody" refers to a polypeptide comprising a framework region from an immunoglobulin gene or fragments thereof that specifically binds and recognizes an antigen. The recognized immunoglobulin genes include the kappa, lambda, alpha, gamma, delta, epsilon, and mu constant region genes, as well as the myriad immunoglobulin variable region genes. Light chains are classified as either kappa or lambda. Heavy chains are classified as gamma, mu, alpha, delta, or epsilon, which in turn define the immunoglobulin classes, IgG, IgM, IgA, IgD, and IgE, respectively. Typically, the antigen-binding region of an antibody or its functional equivalent will be most critical in specificity and affinity of binding. See Paul, Fundamental Immunology.

An exemplary immunoglobulin (antibody) structural unit comprises a tetramer. Each tetramer is composed of two identical pairs of polypeptide chains, each pair having one "light" (about 25 kD) and one "heavy" chain (about 50-70 kD). The N-terminus of each chain defines a variable region of about 100 to 110 or more amino acids primarily responsible for antigen recognition. The terms variable light chain (V ) and variable heavy chain (V_H) refer to these light and heavy chains respectively.

Antibodies exist, e.g., as intact immunoglobulins or as a number of well-characterized fragments produced by digestion with various peptidases. Thus, e.g., pepsin digests an antibody below the disulfide linkages in the hinge region to produce F(ab)'₂₎ a dimer of Fab which itself is a light chain joined to V_H-C_H1 by a disulfide bond. The F(ab)'₂ may be reduced under mild conditions to break the disulfide linkage in the hinge region, thereby converting the F(ab)'₂ dimer into an Fab' monomer. The Fab' monomer is essentially Fab with part ofthe hinge region (see Paul (ed. 1999) Fundamental Immunology (4th ed.). While various antibody fragments are defined in terms ofthe digestion of an intact antibody, one of skill will appreciate that such fragments may be synthesized de novo either chemically or by using recombinant DNA methodology. Thus, the term antibody, as used herein, also includes antibody fragments either produced by the modification of whole antibodies, or those synthesized de novo using recombinant DNA methodologies (e.g., single chain Fv) or those identified using phage display libraries (see, e.g., McCafferty, et al. (1990) Nature 348:552- 554).

For preparation of antibodies, e.g., recombinant, monoclonal, or polyclonal antibodies, many technique known in the art can be used (see, e.g., Kohler and Milstein (1975) Nature 256:495-497; Kozbor, et al. (1983) Immunology Today 4:72; Cole, et al. (1985), pp. 77-96 in Monoclonal Antibodies and Cancer Therapy: Coligan (1991 and supplements) Current Protocols in Immunology: Harlow and Lane (1988) Antibodies. A Laboratory Manual: and Goding (1986) Monoclonal Antibodies: Principles and Practice (2d ed.)). Techniques for the production of single chain antibodies (U.S. Patent 4,946,778) can be adapted to produce antibodies to polypeptides of this invention. Also, transgenic mice, or other organisms such as other mammals, may be used to express humanized antibodies. Alternatively, phage display technology can be used to identify antibodies and heteromeric Fab fragments that specifically bind to selected antigens (see, e.g., McCafferty, et al. (1990) Nature 348:552-554; Marks, et al. (1992) Biotechnology 10:779-783).

A "chimeric antibody" is an antibody molecule in which, e.g, (a) the constant region, or a portion thereof, is altered, replaced, or exchanged so that the antigen binding site (variable region) is linked to a constant region of a different or altered class, effector function, and/or species, or an entirely different molecule which confers new properties to the chimeric antibody, e.g., an enzyme, toxin, hormone, growth factor, drug, etc.; or (b) the variable region, or a portion thereof, is altered, replaced, or exchanged with a variable region having a different or altered antigen specificity.

Identification of lung cancer-associated sequences In one aspect, the expression levels of genes are determined in different patient samples for which diagnosis information is desired, to provide expression profiles. An expression profile of a particular sample is essentially a "fingerprint" ofthe state ofthe sample; while two states may have any particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is characteristic ofthe state ofthe cell. That is, normal tissue may be distinguished from cancerous or metastatic cancerous tissue, or metastatic cancerous tissue can be compared with tissue from surviving cancer patients. By comparing expression profiles of tissue in known different lung cancer states, information regarding which genes are important (including both up- and down-regulation of genes) in each of these states is obtained. Molecular profiling may distinguish subtypes of a currently collective disease designation, e.g., different forms of lung cancer (chronic disease, adenocarcinoma, etc.)

The identification of sequences that are differentially expressed in lung cancer versus non-lung cancer tissue allows the use of this information in a number of ways. For example, a particular freatment regime may be evaluated: does a chemotherapeutic drug act to down- regulate lung cancer, and thus tumor growth or recurrence, in a particular patient.

Alternatively, a freatment step may induce other markers which may be used as targets to destroy tumor cells. Similarly, diagnosis and freatment outcomes may be done or confirmed by comparing patient samples with the known expression profiles. Malignant diseasemay be compared to non-malignant conditions. Metastatic tissue can also be analyzed to determine the stage of lung cancer in the tissue, or origin of primary tumor, e.g., metastasis from a remote primary site. Furthermore, these gene expression profiles (or individual genes) allow screening of drug candidates with an eye to mimicking or altering a particular expression profile; e.g., screening can be done for drugs that suppress the lung cancer expression profile. This may be done by making biochips comprising sets ofthe important lung cancer genes, which can then be used in these screens. PCR methods may be applied with selected primer pairs, and analysis may be of RNA or of genomic sequences. These methods can also be done on the protein basis; that is, protein expression levels ofthe lung cancer proteins can be evaluated for diagnostic purposes or to screen candidate agents. In addition, the lung cancer nucleic acid sequences can be administered for gene therapy purposes, including the adminisfration of antisense nucleic acids, or the lung cancer proteins (including antibodies and other modulators thereof) administered as therapeutic drugs or as protein or DNA vaccines. Thus the present invention provides nucleic acid and protein sequences that are differentially expressed in lung cancer relative to normal tissues and/or non-malignant lung disease, or in different types of lung disease, herein termed "lung cancer sequences." As outlined below, lung cancer sequences include those that are up-regulated (i.e., expressed at a higher level) in lung cancer, as well as those that are down-regulated (i.e., expressed at a lower level). In a preferred embodiment, the lung cancer sequences are from humans; however, as will be appreciated by those in the art, lung cancer sequences from other organisms may be useful in animal models of disease and drug evaluation; thus, other lung cancer sequences are provided, from vertebrates, including mammals, including rodents (rats, mice, hamsters, guinea pigs, etc.), primates, farm animals (including sheep, goats, pigs, cows, horses, etc.) and pets (dogs, cats, etc.). Lung cancer sequences from other organisms may be obtained using the techniques outlined below.

Lung cancer sequences can include both nucleic acid and amino acid sequences. As will be appreciated by those in the art and is more fully outlined below, lung cancer nucleic acid sequences are useful in a variety of applications, including diagnostic applications, which will detect naturally occurring nucleic acids, as well as screening applications; e.g., biochips comprising nucleic acid probes or PCR microtiter plates with selected probes to the lung cancer sequences can be generated.

A lung cancer sequence can be initially identified by substantial nucleic acid and/or amino acid sequence homology to the lung cancer sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, e.g., using homology programs or hybridization conditions.

For identifying lung cancer-associated sequences, the lung cancer screen typically includes comparing genes identified in different tissues, e.g., normal and cancerous tissues, cancer and non-malignant conditions, non-malignant conditions and normal tissues, or tumor tissue samples from patients who have metastatic disease vs. non metastatic tissue. Other suitable tissue comparisons include comparing lung cancer samples with metastatic cancer samples from other cancers, such as, breast, other gastrointestinal cancers, prostate, ovarian, etc. Samples of, non metastatic disease tissue and tissue undergoing metastasis are applied to biochips comprising nucleic acid probes. The samples are first microdissected, if applicable, and treated as is known in the art for the preparation of mRNA. Suitable biochips are commercially available, e.g., from Affymetrix, Santa Clara, CA. Gene expression profiles as described herein are generated and the data analyzed.

In one embodiment, the genes showing changes in expression as between normal and disease states are compared to genes expressed in other normal tissues, preferably normal lung, but also including, and not limited to colon, heart, brain, liver, breast, kidney, muscle, prostate, small intestine, large intestine, spleen, bone, and/or placenta. In a preferred embodiment, those genes identified during the lung cancer screen that are expressed in significant amounts in other tissues (e.g., essential organs) are removed from the profile, although in some embodiments, this is not necessary (e.g., where organs may be dispensible at a later stage of life). That is, when screening for drugs, it is usually preferable that the target expression be disease specific, to minimize possible side effects on other organs. In a preferred embodiment, lung cancer sequences are those that are up-regulated in lung cancer; that is, the expression of these genes is higher in cancerous tissue than in normal lung or other tissue. "Up-regulation" as used herein means, when the ratio is presented as a number greater than one, that the ratio is greater than one, preferably 1.5 or greater, more preferably 2.0 or greater. Another embodiment is directed to sequences up-regulated in non- malignant conditions relative to normal. Unigene cluster identification numbers and accession numbers herein are for the GenBank sequence database and the sequences ofthe accession numbers are hereby expressly incorporated by reference. GenBank is known in the art, see, e.g., Benson, DA, et al (1998) Nucleic Acids Research 26:1-7 and http://www.ncbi.nlm.nih.gov/. Sequences are also available in other databases, e.g., European Molecular Biology Laboratory (EMBL) and DNA Database of Japan (DDBJ). Another embodiment is directed to sequences up-regulated in non-malignant conditions relative to normal. In some situations, the sequences may be derived from assembly of available sequences or be predicted from genomic DNA using exon prediction algorithms, such as FGENESH (Salamov and Solovyev (2000) Genome Res. 10:516-522). In other situations, sequences have been derived from cloning and sequencing of isolated nucleic acids.

In another preferred embodiment, lung cancer sequences are those that are downregulated in the lung cancer; that is, the expression of these genes is lower in cancerous tissue or normal lung or other tissue. "Down-regulation" as used herein means, when the ratio is presented as a number greater than one, that the ratio is greater than one, preferably 1.5 or greater, more preferably 2.0 or greater, or, when the ratio is presented as a number less than one, that the ratio is less than one, preferably 0.5 or less, more preferably 0.25 or less.

Informatics

The ability to identify genes that are over or under expressed in lung cancer can additionally provide high-resolution, high-sensitivity datasets which can be used in the areas of diagnostics, therapeutics, drug development, pharmacogenetics, protein structure, biosensor development, and other related areas. For example, the expression profiles can be used in diagnostic or prognostic evaluation of patients with lung cancer. Or as another example, subcellular toxicological information can be generated to better direct drug stracture and activity correlation (see Anderson (1998) Pharmaceutical Proteomics: Targets. Mechanism, and Function, paper presented at the IBC Proteomics conference, Coronado, CA (June 11-12, 1998)). Subcellular toxicological information can also be utilized in a biological sensor device to predict the likely toxicological effect of chemical exposures and likely tolerable exposure thresholds (see U.S. Patent No. 5,811,231). Similar advantages accrue from datasets relevant to other biomolecules and bioactive agents (e.g., nucleic acids, saccharides, lipids, drugs, and the like). Thus, in another embodiment, the present invention provides a database that includes at least one set of assay data. The data contained in the database is acquired, e.g., using array analysis either singly or in a library format. The database can be in a form in which data can be maintained and transmitted, but is preferably an electronic database. The electronic database ofthe invention can be maintained on any electronic device allowing for the storage of and access to the database, such as a personal computer, but is preferably distributed on a wide area network, such as the World Wide Web.

The focus ofthe present section on databases that include peptide sequence data is for clarity of illusfration only. It will be apparent to those of skill in the art that similar databases can be assembled for assay data acquired using an assay ofthe invention. The compositions and methods for identifying and/or quantitating the relative and/or absolute abundance of a variety of molecular and macromolecular species from a biological sample representing lung cancer, i.e., the identification of lung cancer-associated sequences described herein, provide an abundance of information, which can be correlated with pathological conditions, predisposition to disease, drag testing, therapeutic monitoring, gene- disease causal linkages, identification of correlates of immunity and physiological status, among others. Although the data generated from the assays ofthe invention is suited for manual review and analysis, in a preferred embodiment, data processing using high-speed computers is utilized.

An array of methods for indexing and retrieving biomolecular information is known in the art. For example, U.S. Patents 6,023,659 and 5,966,712 disclose a relational database system for storing biomolecular sequence information in a manner that allows sequences to be catalogued and searched according to one or more protein function hierarchies. U.S. Patent 5,953,727 discloses a relational database having sequence records containing information in a format that allows a collection of partial-length DNA sequences to be catalogued and searched according to association with one or more sequencing projects for obtaining full-length sequences from the collection of partial length sequences. U.S. Patent 5,706,498 discloses a gene database retrieval system for making a retrieval of a gene sequence similar to a sequence data item in a gene database based on the degree of similarity between a key sequence and a target sequence. U.S. Patent 5,538,897 discloses a method using mass spectroscopy fragmentation patterns of peptides to identify amino acid sequences in computer databases by comparison of predicted mass specfra with experimentally-derived mass spectra using a closeness-of-fit measure. U.S. Patent 5,926,818 discloses a multi- dimensional database comprising a functionality for multi-dimensional data analysis described as on-line analytical processing (OLAP), which entails the consolidation of projected and actual data according to more than one consolidation path or dimension. U.S. Patent 5,295,261 reports a hybrid database stracture in which the fields of each database record are divided into two classes, navigational and informational data, with navigational fields stored in a hierarchical topological map which can be viewed as a tree stracture or as the merger of two or more such tree structures.

See also Mount, et al. (2001) Bioinformatics; Durbin, et al. (eds., 1999) Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids (; Baxevanis and Oeullette (eds., 1998) Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins'): Rashidi and Buehler (1999 Bioinformatics: Basic Applications in Biological Science and Medicine: Setubal, et al. (eds 1997) Introduction to Computational Molecular Biology: Misener and Krawetz (eds, 2000) Bioinformatics: Methods and Protocols: Higgins and Taylor (eds., 2000) Bioinformatics: Sequence. Structure, and Databanks: A Practical Approach: Brown (2001) Bioinformatics: A Biologist's Guide to Biocomputing and the Internet: Han and Kamber (2000) Data Mining: Concepts and Techniques (2000); and Waterman (1995) Introduction to Computational Biology: Maps. Sequences, and Genomes. The present invention provides a computer database comprising a computer and software for storing in computer-retrievable form assay data records cross-tabulated, e.g., with data specifying the source ofthe target-containing sample from which each sequence specificity record was obtained.

In an exemplary embodiment, at least one ofthe sources of target-containing sample is from a control tissue sample known to be free of pathological disorders. In a variation, at least one ofthe sources is a known pathological tissue specimen, e.g., a neoplastic lesion or another tissue specimen to be analyzed for lung cancer. In another variation, the assay records cross-tabulate one or more ofthe following parameters for each target species in a sample: (1) a unique identification code, which can include, e.g., a target molecular structure and/or characteristic separation coordinate (e.g., electrophoretic coordinates); (2) sample source; and (3) absolute and/or relative quantity ofthe target species present in the sample. The invention also provides for the storage and retrieval of a collection of target data in a computer data storage apparatus, which can include magnetic disks, optical disks, magneto-optical disks, DRAM, SRAM, SGRAM, SDRAM, RDRAM, DDR RAM, magnetic bubble memory devices, and other data storage devices, including CPU registers and on-CPU data storage arrays. Typically, the target data records are stored as a bit pattern in an array of magnetic domains on a magnetizable medium or as an array of charge states or transistor gate states, such as an array of cells in a DRAM device (e.g., each cell comprised of a transistor and a charge storage area, which may be on the transistor). In one embodiment, the invention provides such storage devices, and computer systems built therewith, comprising a bit pattern encoding a protein expression fingerprint record comprising unique identifiers for at least 10 target data records cross-tabulated with target source.

When the target is a peptide or nucleic acid, the invention preferably provides a method for identifying related peptide or nucleic acid sequences, comprising performing a computerized comparison between a peptide or nucleic acid sequence assay record stored in or retrieved from a computer storage device or database and at least one other sequence. The comparison can include a sequence analysis or comparison algorithm or computer program embodiment thereof (e.g., FASTA, TFASTA, GAP, BESTFIT) and/or the comparison may be ofthe relative amount of a peptide or nucleic acid sequence in a pool of sequences determined from a polypeptide or nucleic acid sample of a specimen.

The invention also preferably provides a magnetic disk, such as an IBM-compatible (DOS, Windows, Windows95/98/2000, Windows NT, OS/2) or other format (e.g., Linux, SunOS, Solaris, ATX, SCO Unix, VMS, MV, Macintosh, etc.) floppy diskette or hard (fixed, Winchester) disk drive, comprising a bit pattern encoding data from an assay ofthe invention in a file format suitable for retrieval and processing in a computerized sequence analysis, comparison, or relative quantitation method.

The invention also provides a network, comprising a plurality of computing devices linked via a data link, such as an Ethernet cable (coax or lOBaseT), telephone line, ISDN line, wireless network, optical fiber, or other suitable signal transmission medium, whereby at least one network device (e.g., computer, disk array, etc.) comprises a pattern of magnetic domains (e.g., magnetic disk) and/or charge domains (e.g., an array of DRAM cells) composing a bit pattern encoding data acquired from an assay ofthe invention. The invention also provides a method for transmitting assay data that includes generating an electronic signal on an electronic communications device, such as a modem, ISDN terminal adapter, DSL, cable modem, ATM switch, or the like, wherein the signal includes (in native or encrypted format) a bit pattern encoding data from an assay or a database comprising a plurality of assay results obtained by the method ofthe invention. In a preferred embodiment, the invention provides a computer system for comparing a query target to a database containing an array of data structures, such as an assay result obtained by the method ofthe invention, and ranking database targets based on the degree of identity and gap weight to the target data. A central processor is preferably initialized to load and execute the computer program for alignment and/or comparison ofthe assay results. Data for a query target is entered into the central processor via an I/O device. Execution of the computer program results in the central processor retrieving the assay data from the data file, which comprises a binary description of an assay result.

The target data or record and the computer program can be transferred to secondary memory, which is typically random access memory (e.g., DRAM, SRAM, SGRAM, or SDRAM). Targets are ranked according to the degree of correspondence between a selected assay characteristic (e.g., binding to a selected affinity moiety) and the same characteristic of the query target and results are output via an I/O device. For example, a central processor can be a conventional computer (e.g., Intel Pentium, PowerPC, Alpha, PA-8000, SPARC, MIPS 4400, MIPS 10000, VAX, etc.); a program can be a commercial or public domain molecular biology software package (e.g., UWGCG Sequence Analysis Software, Darwin); a data file can be an optical or magnetic disk, a data server, a memory device (e.g., DRAM, SRAM, SGRAM, SDRAM, EPROM, bubble memory, flash memory, etc.); an I/O device can be a terminal comprising a video display and a keyboard, a modem, an ISDN terminal adapter, an Ethernet port, a punched card reader, a magnetic strip reader, or other suitable I/O device.

The invention also preferably provides the use of a computer system, such as that described above, which comprises: (1) a computer; (2) a stored bit pattern encoding a collection of peptide sequence specificity records obtained by the methods ofthe invention, which may be stored in the computer; (3) a comparison target, such as a query target; and (4) a program for alignment and comparison, typically with rank-ordering of comparison results on the basis of computed similarity values.

Characteristics of lung cancer-associated proteins

Lung cancer proteins ofthe present invention may be classified as secreted proteins, transmembrane proteins or intracellular proteins. In one embodiment, the lung cancer protein is an intracellular protein. Intracellular proteins may be found in the cytoplasm and/or in the nucleus. Intracellular proteins are involved in all aspects of cellular function and replication (including, e.g., signaling pathways); aberrant expression of such proteins often results in unregulated or disregulated cellular processes (see, e.g., Alberts (ed. 1994) Molecular Biology ofthe Cell (3d ed.). For example, many intracellular proteins have enzymatic activity such as protein kinase activity, protein phosphatase activity, protease activity, nucleotide cyclase activity, polymerase activity and the like. Intracellular proteins also serve as docking proteins that are involved in organizing complexes of proteins, or targeting proteins to various subcellular localizations, and are involved in maintaining the structural integrity of organelles.

An increasingly appreciated concept in characterizing proteins is the presence in the proteins of one or more structural motifs for which defined functions have been attributed. In addition to the highly conserved sequences found in the enzymatic domain of proteins, highly conserved sequences have been identified in proteins that are involved in protein-protein interaction. For example, Src-homology-2 (SH2) domains bind tyrosine-phosphorylated targets in a sequence dependent manner. PTB domains, which are distinct from SH2 domains, also bind tyrosine phosphorylated targets. SH3 domains bind to proline-rich targets. In addition, PH domains, tetratricopeptide repeats and WD domains to name only a few, have been shown to mediate protein-protein interactions. Some of these may also be involved in binding to phosphohpids or other second messengers. As will be appreciated by one of ordinary skill in the art, these motifs can be identified on the basis of amino acid sequence; thus, an analysis ofthe sequence of proteins may provide insight into both the enzymatic potential ofthe molecule and/or molecules with which the protein may associate. One useful database is Pfam (protein families), which is a large collection of multiple sequence alignments and hidden Markov models covering many common protein domains. Versions are available via the internet from Washington University in St. Louis, the Sanger Center in England, and the Karolinska Institute in Sweden (see, e.g., Bateman, et al (2000) Nuc. Acids Res. 28:263-266; Sonnhammer, et al. (1997) Proteins 28:405-420; Bateman, et al. (1999) Nuc. Acids Res. 27:260-262; and Sonnhammer, et al. (1998) Nuc. Acids Res. 26:320- 322). In another embodiment, the lung cancer sequences are fransmembrane proteins.

Transmembrane proteins are molecules that span a phosphohpid bilayer of a cell. They may have an intracellular domain, an extracellular domain, or both. The intracellular domains of such proteins may have a number of functions including those already described for intracellular proteins. For example, the intracellular domain may have enzymatic activity and/or may serve as a binding site for additional proteins. Frequently the intracellular domain of transmembrane proteins serves both roles. For example certain receptor tyrosine kinases have both protein kinase activity and SH2 domains. In addition, autophosphorylation of tyrosines on the receptor molecule itself, creates binding sites for additional SH2 domain containing proteins. Transmembrane proteins may contain from one to many transmembrane domains.

For example, receptor tyrosine kinases, certain cytokine receptors, receptor guanylyl cyclases and receptor serine/threonine protein kinases contain a single transmembrane domain. However, various other proteins including channels, pumps, and adenylyl cyclases contain numerous transmembrane domains. Many important cell surface receptors such as G protein coupled receptors (GPCRs) are classified as "seven fransmembrane domain" proteins, as they contain 7 membrane spanning regions. Characteristics of transmembrane domains include approximately 17 consecutive hydrophobic amino acids that may be followed by charged amino acids. Therefore, upon analysis ofthe amino acid sequence of a particular protein, the localization and number of fransmembrane domains within the protein may be predicted (see, e.g., PSORT web site http://psort.nibb.ac.jp/).

The extracellular domains of transmembrane proteins are diverse; however, conserved motifs are found repeatedly among various extracellular domains. Conserved structure and/or functions have been ascribed to different exfracellular motifs. Many extracellular domains are involved in binding to other molecules. In one aspect, extracellular domains are found on receptors. Factors that bind the receptor domain include circulating ligands, which may be peptides, proteins, or small molecules such as adenosine and the like. For example, growth factors such as EGF, FGF, and PDGF are circulating growth factors that bind to their cognate receptors to initiate a variety of cellular responses. Other factors include cytokines, mitogenic factors, hormones, neurotrophic factors and the like. Extracellular domains also bind to cell-associated molecules. In this respect, they may mediate cell-cell interactions. Cell-associated ligands can be tethered to the cell, e.g., via a glycosylphosphatidylinositol (GPI) anchor, or may themselves be transmembrane proteins. Extracellular domains may also associate with the extracellular matrix and contribute to the maintenance ofthe cell structure.

Lung cancer proteins that are fransmembrane are particularly preferred in the present invention as they are readily accessible targets for exfracellular immunotherapeutics, as are described herein. In addition, as outlined below, transmembrane proteins can be also useful in imaging modalities. Antibodies may be used to label such readily accessible proteins in situ or in histological analysis. Alternatively, antibodies can also label intracellular proteins, in which case analytical samples are typically permeablized to provide access to intracellular proteins. In addition, some membrane proteins can be processed to release a soluble protein, or to expose a residual fragment. Released soluble proteins may be useful diagnostic markers, processed residual protein fragments may be useful lung markers of disease.

It will also be appreciated by those in the art that a transmembrane protein can be made soluble by removing fransmembrane sequences, e.g., through recombinant methods. Furthermore, transmembrane proteins that have been made soluble can be made to be secreted through recombinant means by adding an appropriate signal sequence. In another embodiment, the lung cancer proteins are secreted proteins; the secretion of which can be either constitutive or regulated. These proteins may have a signal peptide or signal sequence that targets the molecule to the secretory pathway. Secreted proteins are involved in numerous physiological events; e.g., if circulating, they often serve to transmit signals to various other cell types. The secreted protein may function in an autocrine manner (acting on the cell that secreted the factor), a paracrine manner (acting on cells in close proximity to the cell that secreted the factor), an endocrine manner (acting on cells at a distance, e.g., secretion into the blood stream), or exocrine (secretion, e.g., through a duct or to adjacent epithelial surface as sweat glands, sebaceous glands, pancreatic ducts, lacrimal glands, mammary glands, sax producing glands ofthe ear, etc.). Thus secreted molecules often find use in modulating or altering numerous aspects of physiology. Lung cancer proteins that are secreted proteins are particularly preferred in the present invention as they serve as good targets for diagnostic markers, e.g., for blood, plasma, serum, or stool tests. Those which are enzymes may be antibody or small molecule targets. Others may be useful as vaccine targets, e.g., via CTL mechanisms.

Use of lung cancer nucleic acids

As described above, lung cancer sequence is initially identified by substantial nucleic acid and/or amino acid sequence homology or linkage to the lung cancer sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, using either homology programs or hybridization conditions. Typically, linked sequences on a mRNA are found on the same molecule. The lung cancer nucleic acid sequences ofthe invention, e.g., the sequences in Tables

1A-16, can be fragments of larger genes, i.e., they are nucleic acid segments. "Genes" in this context includes coding regions, non-coding regions, and mixtures of coding and non-coding regions. Accordingly, as will be appreciated by those in the art, using the sequences provided herein, extended sequences, in either direction, ofthe lung cancer genes can be obtained, using techniques well known in the art for cloning either longer sequences or the full length sequences; see Ausubel, et al, supra. Much can be done by informatics and many sequences can be clustered to include multiple sequences corresponding to a single gene, e.g., systems such as UniGene (see, http://www.ncbi.nlm.nih.gov/UniGene/).

Once a lung cancer nucleic acid is identified, it can be cloned and, if necessary, its constituent parts recombined to form the entire lung cancer nucleic acid coding regions or the entire mRNA sequence. Once isolated from its natural source, e.g., contained within a plasmid or other vector or excised therefrom as a linear nucleic acid segment, the recombinant lung cancer nucleic acid can be further-used as a probe to identify and isolate other lung cancer nucleic acids, e.g., extended coding regions. It can also be used as a "precursor" nucleic acid to make modified or variant lung cancer nucleic acids and proteins. The lung cancer nucleic acids ofthe present invention are used in several ways. In a first embodiment, nucleic acid probes to the lung cancer nucleic acids are made and attached to biochips to be used in screening and diagnostic methods, as outlined below, or for administration, e.g., for gene therapy, RNAi, vaccine, and/or antisense applications. Alternatively, the lung cancer nucleic acids that include coding regions of lung cancer proteins can be put into expression vectors for the expression of lung cancer proteins, again for screening purposes or for administration to a patient. In a preferred embodiment, nucleic acid probes to lung cancer nucleic acids (both the nucleic acid sequences outlined in the figures and/or the complements thereof) are made. The nucleic acid probes attached to the biochip are designed to be substantially complementary to the lung cancer nucleic acids, i.e., the target sequence (either the target sequence ofthe sample or to other probe sequences, e.g., in sandwich assays), such that hybridization of the target sequence and the probes of the present invention occurs. As outlined below, this complementarity need not be perfect; there may be any number of base pair mismatches which will interfere with hybridization between the target sequence and the single stranded nucleic acids ofthe present invention. However, if the number of mutations is so great that no hybridization can occur under even the least stringent of hybridization conditions, the sequence is not a complementary target sequence. Thus, by "substantially complementary" herein is meant that the probes are sufficiently complementary to the target sequences to hybridize under appropriate reaction conditions, particularly high stringency conditions, as outlined herein.

A nucleic acid probe is generally single stranded but can be partially single and partially double stranded. The sfrandedness ofthe probe is dictated by the structure, composition, and properties ofthe target sequence. In general, the nucleic acid probes range from about 8 to about 100 bases long, with from about 10 to about 80 bases being preferred, and from about 30 to about 50 bases being particularly preferred. That is, generally complements of ORFs or whole genes are not used. In some embodiments, nucleic acids of lengths up to hundreds of bases can be used.

In a preferred embodiment, more than one probe per sequence is used, with either overlapping probes or probes to different sections ofthe target being used. That is, two, three, four or more probes, with three being preferred, are used to build in a redundancy for a particular target. The probes can be overlapping (i.e., have some sequence in common), or separate. In some cases, PCR primers may be used to amplify signal for higher sensitivity.

As will be appreciated by those in the art, nucleic acids can be attached or immobilized to a solid support in a wide variety of ways. By "immobilized" and grammatical equivalents herein is meant the association or binding between the nucleic acid probe and the solid support is sufficient to be stable under the conditions of binding, washing, analysis, and removal as outlined below. The binding can typically be covalent or non-covalent. By "non- covalent binding" and grammatical equivalents herein is typically meant one or more of electrostatic, hydrophilic, and hydrophobic interactions. Included in non-covalent binding is the covalent attachment of a molecule, such as, streptavidin to the support and the non- covalent binding ofthe biotinylated probe to the streptavidin. By "covalent binding" and grammatical equivalents herein is meant that the two moieties, the solid support and the probe, are attached by at least one bond, including sigma bonds, pi bonds and coordination bonds. Covalent bonds can be formed directly between the probe and the solid support or can be formed by a cross linker or by inclusion of a specific reactive group on either the solid support or the probe or both molecules. Immobilization may also involve a combination of covalent and non-covalent interactions.

In general, the probes are attached to a biochip in a wide variety of ways, as will be appreciated by those in the art. As described herein, the nucleic acids can either be synthesized first, with subsequent attachment to the biochip, or can be directly synthesized on the biochip.

The biochip comprises a suitable solid substrate. By "substrate" or "solid support" or other grammatical equivalents herein is meant a material that can be modified for the attachment or association ofthe nucleic acid probes and is amenable to at least one detection method. Often the substrate may contain discrete individual sites appropriate for ndivitual partitioning and identification. As will be appreciated by those in the art, the number of possible substrates are very large, and include, but are not limited to, glass and modified or functionalized glass, plastics (including acrylics, polystyrene and copolymers of styrene and other materials, polypropylene, polyethylene, polybutylene, polyurethanes, Teflon, etc.), polysaccharides, nylon or nitrocellulose, resins, silica or silica-based materials including silicon and modified silicon, carbon, metals, inorganic glasses, plastics, etc. In general, the substrates allow optical detection and do not appreciably fluoresce. A preferred substrate is described in US application entitled Reusable Low Fluorescent Plastic Biochip, U.S. Application Serial No. 09/270,214, filed March 15, 1999, herein incoφorated by reference in its entirety.

Generally the substrate is planar, although as will be appreciated by those in the art, other configurations of substrates may be used as well. For example, the probes may be placed on the inside surface of a tube, for flow-through sample analysis to minimize sample volume. Similarly, the substrate may be flexible, such as a flexible foam, including closed cell foams made of particular plastics.

In a preferred embodiment, the surface ofthe biochip and the probe may be derivatized with chemical functional groups for subsequent attachment ofthe two. Thus, e.g., the biochip is derivatized with a chemical functional group including, but not limited to, amino groups, carboxy groups, oxo groups and thiol groups, with amino groups being particularly preferred. Using these functional groups, the probes can be attached using functional groups on the probes. For example, nucleic acids containing amino groups can be attached to surfaces comprising amino groups, e.g., using linkers as are known in the art; e.g., homo-or hetero-bifunctional linkers as are well known (see 1994 Pierce Chemical Company catalog, technical section on cross-linkers, pages 155-200). In addition, in some cases, additional linkers, such as alkyl groups (including substituted and heteroalkyl groups) may be used.

In this embodiment, oligonucleotides are synthesized, and then attached to the surface ofthe solid support. Either the 5' or 3' terminus may be attached to the solid support, or attachment may be via linkage to an internal nucleoside.

In another embodiment, the immobilization to the solid support may be very strong, yet non-covalent. For example, biotinylated oligonucleotides can be made, which bind to surfaces covalently coated with streptavidin, resulting in attachment. Alternatively, the oligonucleotides may be synthesized on the surface, as is known in the art. For example, photoactivation techniques utilizing photopolymerization compounds and techniques are used. In a preferred embodiment, the nucleic acids can be synthesized in situ, using known photolithographic techniques, such as those described in WO 95/25116;

WO 95/35505; U.S. Patent Nos. 5,700,637 and 5,445,934; and references cited within, all of which are expressly incoφorated by reference; these methods of attachment form the basis of the Affymetrix GeneChip™ technology.

Often, amplification-based assays are performed to measure the expression level of lung cancer-associated sequences. These assays are typically performed in conjunction with reverse transcription. In such assays, a lung cancer-associated nucleic acid sequence acts as a template in an amplification reaction (e.g., Polymerase Chain Reaction, or PCR). In a quantitative amplification, the amount of amplification product will be proportional to the amount of template in the original sample. Comparison to appropriate controls provides a measure ofthe amount of lung cancer-associated RNA. Methods of quantitative amplification are well known to those of skill in the art. Detailed protocols for quantitative PCR are provided, e.g., in Innis, et al. (1990) PCR Protocols. A Guide to Methods and Applications.

In some embodiments, a TaqMan based assay is used to measure expression. TaqMan based assays use a fluorogenic oligonucleotide probe that contains a 5' fluorescent dye and a 3' quenching agent. The probe hybridizes to a PCR product, but cannot itself be extended due to a blocking agent at the 3 ' end. When the PCR product is amplified in subsequent cycles, the 5' nuclease activity ofthe polymerase, e.g., AmpliTaq, results in the cleavage ofthe TaqMan probe. This cleavage separates the 5' fluorescent dye and the 3' quenching agent, thereby resulting in an increase in fluorescence as a function of amplification (see, e.g., literature provided by Perkin-Elmer, e.g., www2.perkin-elmer.com).

Other suitable amplification methods include, but are not limited to, ligase chain reaction (LCR) (see Wu and Wallace (1989) Genomics 4:560, Landegren, et al. (1988) Science 241:1077, and Barringer, et al. (1990) Gene 89:117), transcription amplification (Kwoh, et al. (1989) Proc. Natl. Acad. Sci. USA 86:1173), self-sustained sequence replication (Guatelli, et al. (1990) Proc. Nat. Acad. Sci. USA 87:1874), dot PCR, and linker adapter PCR, etc.

Expression of lung cancer proteins from nucleic acids In a preferred embodiment, lung cancer nucleic acids, e.g., encoding lung cancer proteins, are used to make a variety of expression vectors to express lung cancer proteins which can then be used in screening assays, as described below. Expression vectors and recombinant DNA technology are well known to those of skill in the art (see, e.g., Ausubel, supra, and Fernandez and Hoeffler (eds 1999) Gene Expression Systems and are used to express proteins. The expression vectors may be either self-replicating exfrachromosomal vectors or vectors which integrate into a host genome. Generally, these expression vectors include transcriptional and translational regulatory nucleic acid operably linked to the nucleic acid encoding the lung cancer protein. The term "control sequences" refers to DNA sequences used for the expression of an operably linked coding sequence in a particular host organism. Control sequences that are suitable for prokaryotes, e.g., include a promoter, optionally an operator sequence, and a ribosome binding site. Eukaryotic cells are known to utilize promoters, polyadenylation signals, and enhancers. Nucleic acid is "operably linked" when it is placed into a functional relationship with another nucleic acid sequence. For example, DNA for a presequence or secretory leader is operably linked to DNA for a polypeptide if it is expressed as a preprotein that participates in the secretion ofthe polypeptide; a promoter or enhancer is operably linked to a coding sequence if it affects the transcription ofthe sequence; or a ribosome bmding site is operably linked to a coding sequence if it is positioned so as to facilitate franslation. Generally, "operably linked" means that the DNA sequences being linked are contiguous, and, in the case of a secretory leader, contiguous and in reading phase. However, enhancers do not have to be contiguous. Linking is typically accomplished by ligation at convenient restriction sites. If such sites do not exist, synthetic oligonucleotide adaptors or linkers are used in accordance with conventional practice. Transcriptional and translational regulatory nucleic acid will generally be appropriate to the host cell used to express the lung cancer protein. Numerous types of appropriate expression vectors, and suitable regulatory sequences are known in the art for a variety of host cells.

In general, transcriptional and translational regulatory sequences may include, but are not limited to, promoter sequences, ribosomal binding sites, franscriptional start and stop sequences, translational start and stop sequences, and enhancer or activator sequences. In a preferred embodiment, the regulatory sequences include a promoter and transcriptional start and stop sequences.

Promoter sequences may be either constitutive or inducible promoters. The promoters may be either naturally occurring promoters or hybrid promoters. Hybrid promoters, which combine elements of more than one promoter, are also known in the art, and are useful in the present invention.

In addition, an expression vector may comprise additional elements. For example, the expression vector may have two replication systems, thus allowing it to be maintained in two organisms, e.g., in mammalian or insect cells for expression and in a prokaryotic host for cloning and amplification. Furthermore, for integrating expression vectors, the expression vector often contains at least one sequence homologous to the host cell genome, and preferably two homologous sequences which flank the expression construct. The integrating vector may be directed to a specific locus in the host cell by selecting the appropriate homologous sequence for inclusion in the vector. Constructs for integrating vectors are well known in the art (e.g., Fernandez and Hoeffler, supra).

In addition, in a preferred embodiment, the expression vector contains a selectable marker gene to allow the selection of transformed host cells. Selection genes are well known in the art and will vary with the host cell used.

The lung cancer proteins ofthe present invention are usually produced by culturing a host cell transformed with an expression vector containing nucleic acid encoding a lung cancer protein, under the appropriate conditions to induce or cause expression ofthe lung cancer protein. Conditions appropriate for lung cancer protein expression will vary with the choice ofthe expression vector and the host cell, and will be easily ascertained by one skilled in the art through routine experimentation or optimization. For example, the use of constitutive promoters in the expression vector will require optimizing the growth and proliferation ofthe host cell, while the use of an inducible promoter requires the appropriate growth conditions for induction. In addition, in some embodiments, the timing ofthe harvest is important. For example, the baculoviral systems used in insect cell expression are lytic viruses, and thus harvest time selection can be crucial for product yield.

Appropriate host cells include yeast, bacteria, archaebacteria, fungi, and insect and animal cells, including mammalian cells. Of particular interest are Saccharomyces cerevisiae and other yeasts, E. coli, Bacillus subtilis, Sf9 cells, C129 cells, 293 cells, Neurospora, BHK, CHO, COS, HeLa cells, HUVΕC (human umbilical vein endothelial cells), THP1 cells (a macrophage cell line) and various other human cells and cell lines.

In a preferred embodiment, the lung cancer proteins are expressed in mammalian cells. Mammalian expression systems are also known in the art, and include retroviral and adenoviral systems. Of particular use as mammalian promoters are the promoters from mammalian viral genes, since the viral genes are often highly expressed and have a broad host range. Examples include the SV40 early promoter, mouse mammary tumor virus LTR promoter, adenovirus major late promoter, heφes simplex virus promoter, and the CMV promoter (see, e.g., Fernandez and Hoeffler, supra). Typically, transcription termination and polyadenylation sequences recognized by mammalian cells are regulatory regions located 3 ' to the translation stop codon and thus, together with the promoter elements, flank the coding sequence. Examples of transcription terminator and polyadenylation signals include those derived form SV40. The methods of introducing exogenous nucleic acid into mammalian hosts, as well as other hosts, is well known in the art, and will vary with the host cell used. Techniques include dextran-mediated transfection, calcium phosphate precipitation, polybrene mediated transfection, protoplast fusion, electroporation, viral infection, encapsulation ofthe 5 polynucleotide(s) in liposomes, and direct microinjection ofthe DNA into nuclei.

In a preferred embodiment, lung cancer proteins are expressed in bacterial systems. Promoters from bacteriophage may also be used and are known in the art. In addition, synthetic promoters and hybrid promoters are also useful; e.g., the tac promoter is a hybrid of the tφ and lac promoter sequences. Furthermore, a bacterial promoter can include naturally

10 occurring promoters of non-bacterial origin that have the ability to bind bacterial RNA polymerase and initiate transcription. In addition to a functioning promoter sequence, an efficient ribosome binding site is desirable. The expression vector may also include a signal peptide sequence that provides for secretion ofthe lung cancer protein in bacteria. The protein is either secreted into the growth media (gram-positive bacteria) or into the

15 periplasmic space, located between the inner and outer membrane ofthe cell (gram-negative bacteria). The bacterial expression vector may also include a selectable marker gene to allow for the selection of bacterial strains that have been transformed. Suitable selection genes include genes which render the bacteria resistant to drags such as ampicillin, chloramphenicol, erythromycin, kanamycin, neomycin and tetracycline. Selectable markers

.0 also include biosynthetic genes, such as those in the histidine, tryptophan and leucine biosynthetic pathways. These components are assembled into expression vectors. Expression vectors for bacteria are well known in the art, and include vectors for Bacillus subtilis, E. coli, Streptococcus cremoris, and Streptococcus lividans, among others (e.g., Fernandez and Hoeffler, supra). The bacterial expression vectors are transformed into bacterial host cells

£5 using techniques well known in the art, such as calcium chloride freatment, elecfroporation, and others.

In one embodiment, lung cancer proteins are produced in insect cells. Expression vectors for the fransformation of insect cells, and in particular, baculoviras-based expression vectors, are well known in the art.

SO In a preferred embodiment, lung cancer protein is produced in yeast cells. Yeast expression systems are well known in the art, and include expression vectors for Saccharomyces cerevisiae, Candida albicans and C. maltosa, Hansenula polymorpha, Kluyveromyces fragilis and K. lactis, Pichia guillerimondii, and P. pastoris, Schizosaccharomyces pombe, and Yarrowia lipolytica.

The lung cancer protein may also be made as a fusion protein, using techniques well known in the art. Thus, e.g., for the creation of monoclonal antibodies, if the desired epitope is small, the lung cancer protein may be fused to a carrier protein to form an immunogen. Alternatively, the lung cancer protein may be made as a fusion protein to increase expression for affinity purification puφoses, or for other reasons. For example, when the lung cancer protein is a lung cancer peptide, the nucleic acid encoding the peptide may be linked to other nucleic acid for expression purposes. In a preferred embodiment, the lung cancer protein is purified or isolated after expression. Lung cancer proteins may be isolated or purified in a variety of appropriate ways. Standard purification methods include electrophoretic, molecular, immunological and chromatographic techniques, including ion exchange, hydrophobic, affinity, and reverse- phase HPLC chromatography, and chromatofocusing. For example, the lung cancer protein may be purified using a standard anti-lung cancer protein antibody column. Ulfrafiltration and diafilfration techniques, in conjunction with protein concenfration, are also useful. For general guidance in suitable purification techniques, see Scopes (1982) Protein Purification. The degree of purification necessary will vary depending on the use ofthe lung cancer protein. In some instances no purification will be necessary. Once expressed and purified if necessary, the lung cancer proteins and nucleic acids are useful in a number of applications. They may be used as immunoselection reagents, as vaccine reagents, as screening agents, therapeutic entities, for production of antibodies, as transcription or translation inhibitors, etc.

Variants of lung cancer proteins

In one embodiment, the lung cancer proteins are derivative or variant lung cancer proteins as compared to the wild-type sequence. That is, as outlined more fully below, the derivative lung cancer peptide will often contain at least one amino acid substitution, deletion or insertion, with amino acid substitutions being particularly preferred. The amino acid substitution, insertion or deletion may occur at a particular residue within the lung cancer peptide.

Also included within one embodiment of lung cancer proteins ofthe present invention are amino acid sequence variants. These variants typically fall into one or more of three classes: substitutional, insertional or deletional variants. These variants ordinarily are prepared by site specific mutagenesis of nucleotides in the DNA encoding the lung cancer protein, using cassette or PCR mutagenesis or other techniques, to produce DNA encoding the variant, and thereafter expressing the DNA in recombinant cell culture as outlined above. However, variant lung cancer protein fragments having up to about 100-150 residues may be prepared by in vitro synthesis. Amino acid sequence variants are characterized by the predetermined nature ofthe variation, a feature that sets them apart from naturally occurring allelic or interspecies variation ofthe lung cancer protein amino acid sequence. The variants typically exhibit a similar qualitative biological activity as the naturally occurring analogue, although variants can also be selected which have modified characteristics as will be more fully outlined below.

While the site or region for introducing an amino acid sequence variation is often predetermined, the mutation per se need not be predetermined. For example, in order to optimize the performance of a mutation at a given site, random mutagenesis may be conducted at the target codon or region and the expressed lung cancer variants screened for the optimal combination of desired activity. Techniques exist for making substitution mutations at predetermined sites in DNA having a known sequence, e.g., Ml 3 primer mutagenesis and PCR mutagenesis. Screening of mutants is often done using assays of lung cancer protein activities. Amino acid substitutions are typically of single residues; insertions usually will be on the order of from about 1 to 20 amino acids, although considerably larger insertions may be occasionally tolerated. Deletions generally range from about 1 to about 20 residues, although in some cases deletions may be much larger.

Substitutions, deletions, insertions or any combination thereof may be used to arrive at a final derivative. Generally these changes are done on a few amino acids to minimize the alteration ofthe molecule. Larger changes may be tolerated in certain circumstances. When small alterations in the characteristics of a lung cancer protein are desired, substitutions are generally made in accordance with the amino acid substitution chart provided in the definition section. Variants typically exhibit essentially the same qualitative biological activity and will elicit the same immune response as a naturally-occurring analog, although variants also are selected to modify the characteristics of lung cancer proteins as needed. Alternatively, the variant may be designed or reorganized such that a biological activity ofthe lung cancer protein is altered. For example, glycosylation sites may be added, altered, or removed.

Covalent modifications of lung cancer polypeptides are included within the scope of this invention. One type of covalent modification includes reacting targeted amino acid residues of a lung cancer polypeptide with an organic derivatizing agent that is capable of reacting with selected side chains or the N-or C-terminal residues of a lung cancer polypeptide. Derivatization with bifunctional agents is useful, for instance, for crosslinking lung cancer polypeptides to a water-insoluble support matrix or surface for use in a method for purifying anti-lung cancer polypeptide antibodies or screening assays, as is more fully described below. Commonly used crosslinking agents include, e.g., l,l-bis(diazoacetyl)-2- phenylethane, glutaraldehyde, N-hydroxysuccinimide esters, e.g., esters with 4-azidosalicylic acid, homobifunctional imidoesters, including disuccinimidyl esters such as 3,3'- dithiobis(succinimidylpropionate), bifunctional maleimides such as bis-N-maleimido-1,8- octane and agents such as methyl-3-((p-azidophenyl)dithio)propioimidate. Other modifications include deamidation of glutaminyl and asparaginyl residues to the corresponding glutamyl and aspartyl residues, respectively, hydroxylation of proline and lysine, phosphorylation of hydroxyl groups of serinyl, threonyl or tyrosyl residues, methylation ofthe γ-amino groups of lysine, arginine, and histidine side chains (Creighton (1983) Proteins: Structure and Molecular Properties, pp. 79-86), acetylation ofthe N-terminal amine, and amidation of any C-terminal carboxyl group.

Another type of covalent modification ofthe lung cancer polypeptide encompassed by this invention is an altered native glycosylation pattern ofthe polypeptide. "Altering the native glycosylation pattern" is intended herein to mean adding to or deleting one or more carbohydrate moieties of a native sequence lung cancer polypeptide. Glycosylation patterns can be altered in many ways. For example the use of different cell types to express lung cancer-associated sequences can result in different glycosylation patterns.

Addition of glycosylation sites to lung cancer polypeptides may also be accomplished by altering the amino acid sequence thereof. The alteration may be made, e.g., by the addition of, or substitution by, one or more serine or threonine residues to the native sequence lung cancer polypeptide (for O-linked glycosylation sites). The lung cancer amino acid sequence may optionally be altered through changes at the DNA level, particularly by mutating the DNA encoding the lung cancer polypeptide at preselected bases such that codons are generated that will translate into the desired amino acids. Another means of increasing the number of carbohydrate moieties on the lung cancer polypeptide is by chemical or enzymatic coupling of glycosides to the polypeptide. Such methods are described in the art, e.g., in WO 87/05330, and in Aplin and Wriston (1981) CRC Crit. Rev. Biochem.. pp. 259-306. Removal of carbohydrate moieties present on the lung cancer polypeptide may be accomplished chemically or enzymatically or by mutational substitution of codons encoding for amino acid residues that serve as targets for glycosylation. Chemical deglycosylation techniques are known in the art and described, for instance, by Hakimuddin, et al. (1987) Arch. Biochem. Biophvs.. 259:52 and by Edge, et al. (1981) Anal. Biochem.. 118:131. Enzymatic cleavage of carbohydrate moieties on polypeptides can be achieved by the use of a variety of endo-and exo-glycosidases as described by Thotakura, et al. (1987) Meth. Enzymol.. 138:350.

Another type of covalent modification of lung cancer comprises linking the lung cancer polypeptide to one of a variety of nonproteinaceous polymers, e.g., polyethylene glycol, polypropylene glycol, or polyoxyalkylenes, in the manner set forth in U.S. Patent Nos. 4,640,835; 4,496,689; 4,301,144; 4,670,417; 4,791,192, or 4,179,337.

Lung cancer polypeptides ofthe present invention may also be modified in a way to form chimeric molecules comprising a lung cancer polypeptide fused to another, heterologous polypeptide or amino acid sequence. In one embodiment, such a chimeric molecule comprises a fusion of a lung cancer polypeptide with a tag polypeptide which provides an epitope to which an anti-tag antibody can selectively bind. The epitope tag is generally placed at the amino-or carboxyl-terminus ofthe lung cancer polypeptide. The presence of such epitope-tagged forms of a lung cancer polypeptide can be detected using an antibody against the tag polypeptide. Also, provision ofthe epitope tag enables the lung cancer polypeptide to be readily purified by affinity purification using an anti-tag antibody or another type of affinity matrix that binds to the epitope tag. In an alternative embodiment, the chimeric molecule may comprise a fusion of a lung cancer polypeptide with an immunoglobulin or a particular region of an immunoglobulin. For a bivalent form ofthe chimeric molecule, such a fusion could be to the Fc region of an IgG molecule. Various tag polypeptides and their respective antibodies are well known and examples include poly-histidine (poly-his) or poly-histidine-glycine (poly-his-gly) tags; HIS6 and metal chelation tags, the flu HA tag polypeptide and its antibody 12CA5 (Field, et al. (1988) Mol. Cell. Biol. 8:2159-2165); the c-myc tag and the 8F9, 3C7, 6E10, G4, B7 and 9E10 antibodies thereto (Evan, et al. (1985) Molecular and Cellular Biology 5:3610-3616); and the Heφes Simplex virus glycoprotein D (gD) tag and its antibody (Paborsky, et al. (1990) Protein Engineering 3(6):547-553). Other tag polypeptides include the Flag-peptide (Hopp, et al. (1988) BioTechnology 6:1204-1210); the KT3 epitope peptide (Martin, et al. (1992) Science 255:192-194); tubulin epitope peptide (Skinner, et al. (1991) J. Biol. Chem. 266:15163- 15166); and the T7 gene 10 protein peptide tag (Lutz-Freyermuth, et al. (1990) Proc. Nat'l Acad. Sci. USA 87:6393-6397).

Also included are other lung cancer proteins ofthe lung cancer family, and lung cancer proteins from other organisms, which are cloned and expressed as outlined below. Thus, probe or degenerate polymerase chain reaction (PCR) primer sequences may be used to find other related lung cancer proteins from primates or other organisms. As will be appreciated by those in the art, particularly useful probe and/or PCR primer sequences include unique areas ofthe lung cancer nucleic acid sequence. As is generally known in the art, preferred PCR primers are from about 15 to about 35 nucleotides in length, with from about 20 to about 30 being preferred, and may contain inosine as needed. PCR reaction conditions are well known in the art (e.g., Innis, PCR Protocols, supra).

Antibodies to lung cancer proteins

In a preferred embodiment, when a lung cancer protein is to be used to generate antibodies, e.g., for immunotherapy or immunodiagnosis, the lung cancer protein should share at least one epitope or determinant with the full length protein. By "epitope" or "determinant" herein is typically meant a portion of a protein which will generate and/or bind an antibody or T-cell receptor in the context of MHC. Thus, in most instances, antibodies made to a smaller lung cancer protem will be able to bind to the full-length protein, particularly linear epitopes. In a preferred embodiment, the epitope is unique; that is, antibodies generated to a unique epitope show little or no cross-reactivity.

Methods of preparing polyclonal antibodies are well known (e.g., Coligan, supra; and Harlow and Lane, supra). Polyclonal antibodies can be raised in a mammal, e.g., by one or more injections of an immunizing agent and, if desired, an adjuvant. Typically, the immunizing agent and/or adjuvant will be injected in the mammal by multiple subcutaneous or intraperitoneal injections. The immunizing agent may include a protein encoded by a nucleic acid of Tables 1 A- 16 or fragment thereof or a fusion protein thereof. It may be useful to conjugate the immunizing agent to a protein known to be immunogenic in the mammal being immunized. Immunogenic proteins include, e.g., keyhole limpet hemocyanin, serum albumin, bovine thyroglobulin, and soybean trypsin inhibitor. Adjuvants include, e.g., Freund's complete adjuvant and MPL-TDM adjuvant (monophosphoryl Lipid A, synthetic trehalose dicorynomycolate). The immunization protocol may be selected by one skilled in the art.

The antibodies may, alternatively, be monoclonal antibodies. Monoclonal antibodies may be prepared using hybridoma methods, such as those described by Kohler and Milstein (1975) Nature 256:495. In a hybridoma method, a mouse, hamster, or other appropriate host animal, is typically immunized with an immunizing agent to elicit lymphocytes that produce or are capable of producing antibodies that will specifically bind to the immumzing agent. Alternatively, the lymphocytes may be immunized in vitro. The immunizing agent will typically include a polypeptide encoded by a nucleic acid ofthe tables, or fragment thereof, or a fusion protein thereof. Generally, either peripheral blood lymphocytes ("PBLs") are used if cells of human origin are desired, or spleen cells or lymph node cells are used if non- human mammalian sources are desired. The lymphocytes are then fused with an immortalized cell line using a suitable fusing agent, such as polyethylene glycol, to form a hybridoma cell (Goding (1986) Monoclonal Antibodies: Principles and Practice, pp. 59-103 ). Immortalized cell lines are usually transformed mammalian cells, particularly myeloma cells of rodent, bovin, or primate origin. Usually, rat or mouse myeloma cell lines are employed. The hybridoma cells may be cultured in a suitable culture medium that preferably contains one or more substances that inhibit the growth or survival ofthe unfused, immortalized cells. For example, if the parental cells lack the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT or HPRT), the culture medium for the hybridomas typically will include hypoxanthine, aminopterin, and thymidine ("HAT medium"), which substances prevent the growth of HGPRT-deficient cells.

In one embodiment, the antibodies are bispecific antibodies. Bispecific antibodies are typically monoclonal, preferably human or humanized, antibodies that have binding specificities for at least two different antigens or that have binding specificities for two epitopes on the same antigen. In one embodiment, one ofthe binding specificities is for a protein encoded by a nucleic acid ofthe tables or a fragment thereof, the other one is for any other antigen, and preferably for a cell-surface protein or receptor or receptor subunit, preferably one that is tumor specific. Alternatively, teframer-type technology may create multivalent reagents. In a preferred embodiment, the antibodies to lung cancer protein are capable of reducing or eliminating a biological function of a lung cancer protein, in a naked form or conjugated to an effector moiety. That is, the addition of anti-lung cancer protein antibodies (either polyclonal or preferably monoclonal) to lung cancer tissue (or cells containing lung cancer) may reduce or eliminate the lung cancer. Generally, at least a 25% decrease in activity, growth, size or the like is preferred, with at least about 50% being particularly preferred and about a 95-100%) decrease being especially preferred.

In a preferred embodiment the antibodies to the lung cancer proteins are humanized antibodies (e.g., Xenerex Biosciences, Medarex, Inc., Abgenix, Inc., Protein Design Labs, Inc.) Humanized forms of non-human (e.g., murine) antibodies are chimeric molecules of immunoglobulins, immunoglobulin chains or fragments thereof (such as Fv, Fab, Fab', F(ab')2 or other antigen-binding subsequences of antibodies) which contain minimal sequence derived from non-human immunoglobulin. Humanized antibodies include human immunoglobulins (recipient antibody) in which residues from a complementary determining region (CDR) ofthe recipient are replaced by residues from a CDR of a non-human species (donor antibody) such as mouse, rat or rabbit having the desired specificity, affinity and capacity. In some instances, Fv framework residues of a human immunoglobulin are replaced by corresponding non-human residues. Humanized antibodies may also comprise residues which are found neither in the recipient antibody nor in the imported CDR or framework sequences. In general, a humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all ofthe CDR regions correspond to those of a non-human immunoglobulin and all or substantially all of the framework (FR) regions are those of a human immunoglobulin consensus sequence. A humanized antibody optimally also will typically comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin (Jones, et al. (1986) Nature 321:522-525; Riechmann, et al. (1988) Nature 332:323-329; and Presta (1992) Curr. Op. Struct. Biol. 2:593-596). Humanization can be performed following the method of Winter and co-workers (Jones, et al. (1986) Nature 321:522-525; Riechmann, et al. (1988) Nature 332:323-327; Verhoeyen, et al. (1988) Science 239:1534-1536), by substituting rodent CDRs or CDR sequences for corresponding sequences of a human antibody. Accordingly, such humanized antibodies are chimeric antibodies (U.S. Patent No. 4,816,567), wherein substantially less than an intact human variable domain has been substituted by corresponding sequence from a non-human species. Human-like antibodies can also be produced using various techniques known in the art, including phage display libraries (Hoogenboom and Winter (1991) J. Mol. Biol. 227:381; Marks, et al. (1991) J. Mol. Biol. 222:581). The techniques of Cole, et al. and Boerner, et al. are also available for the preparation of human monoclonal antibodies (Cole, et al. (1985) Monoclonal Antibodies and Cancer Therapy, p. 77 and Boerner, et al. (1991) J. Immunol. 147(l):86-95). Similarly, human antibodies can be made by introducing human immunoglobulin loci into transgenic animals, e.g., mice in which the endogenous immunoglobulin genes have been partially or completely inactivated. Upon challenge, human antibody production is observed, which closely resembles that seen in humans in nearly all respects, including gene rearrangement, assembly, and antibody repertoire. This approach is described, e.g., in U.S. Patent Nos. 5,545,807; 5,545,806; 5,569,825; 5,625,126; 5,633,425; 5,661,016, and in the following scientific publications: Marks, et al. (1992) Bio/Technology 10:779-783; Lonberg, et al. (1994) Nature 368:856-859; Morrison (1994) Nature 368:812-13; Fishwild, et al. (1996) Nature Biotechnology 14:845-51; Neuberger (1996) Nature Biotechnology 14:826; and Lonberg and Huszar (1995) Intern. Rev. Immunol. 13:65-93.

By immunotherapy is meant freatment of lung cancer with an antibody raised against a lung cancer proteins. As used herein, immunotherapy can be passive or active. Passive immunotherapy as defined herein is the passive transfer of antibody to a recipient (patient). Active immunization is the induction of antibody and/or T-cell responses in a recipient (patient). Induction of an immune response is the result of providing the recipient with an antigen to which antibodies are raised. The antigen may be provided by injecting a polypeptide against which antibodies are desired to be raised into a recipient, or contacting the recipient with a nucleic acid capable of expressing the antigen and under conditions for expression ofthe antigen, leading to an immune response.

In a preferred embodiment the lung cancer proteins against which antibodies are raised are secreted proteins as described above. Without being bound by theory, antibodies used for freatment, may bind and prevent the secreted protein from binding to its receptor, thereby inactivating the secreted lung cancer protein. In another preferred embodiment, the lung cancer protein to which antibodies are raised is a transmembrane protein. Without being bound by theory, antibodies used for treatment may bind the exfracellular domain ofthe lung cancer protein and prevent it from binding to other proteins, such as circulating ligands or cell-associated molecules. The antibody may cause down-regulation ofthe transmembrane lung cancer protein. The antibody may be a competitive, non-competitive or uncompetitive inhibitor of protein binding to the exfracellular domain ofthe lung cancer protein. The antibody may be an antagonist of the lung cancer protein or may prevent activation of a fransmembrane lung cancer protein, or may induce or suppress a particular cellular pathway. In some embodiments, when the antibody prevents the binding of other molecules to the lung cancer protein, the antibody prevents growth ofthe cell. The antibody may also be used to target or sensitize the cell to cytotoxic agents, including, but not limited to TNF-α, TNF-β, IL-1, LNF-γ, and IL-2, or chemotherapeutic agents including 5FU, vinblastine, actinomycin D, cisplatin, methofrexate, and the like. In some instances the antibody may belong to a sub-type that activates seram complement when complexed with the transmembrane protein thereby mediating cytotoxicity or antigen-dependent cytotoxicity (ADCC). Thus, lung cancer may be treated by administering to a patient antibodies directed against the transmembrane lung cancer protein. Antibody-labeling may activate a co-toxin, localize a toxin payload, or otherwise provide means to locally ablate cells.

In another preferred embodiment, the antibody is conjugated to an effector moiety. The effector moiety can be various molecules, including labeling moieties such as radioactive labels or fluorescent labels, or can be a therapeutic moiety. In one aspect the therapeutic moiety is a small molecule that modulates the activity of a lung cancer protein. In another aspect the therapeutic moiety may modulate an activity of molecules associated with or in close proximity to a lung cancer protein. The therapeutic moiety may inhibit enzymatic or signaling activity such as protease or coUagenase activity associated with lung cancer.

In a preferred embodiment, the therapeutic moiety can also be a cytotoxic agent. In this method, targeting the cytotoxic agent to lung cancer tissue or cells results in a reduction in the number of afflicted cells, thereby reducing symptoms associated with lung cancer.

Cytotoxic agents are numerous and varied and include, but are not limited to, cytotoxic drugs or toxins or active fragments of such toxins. Suitable toxins and their corresponding fragments include diphtheria A chain, exotoxin A chain, ricin A chain, abrin A chain, curcin, crotin, phenomycin, enomycin, saporin, auristatin, and the like. Cytotoxic agents also include radiochemicals made by conjugating radioisotopes to antibodies raised against lung cancer proteins, or binding of a radionuclide to a chelating agent that has been covalently attached to the antibody. Targeting the therapeutic moiety to transmembrane lung cancer proteins not only serves to increase the local concentration of therapeutic moiety in the lung cancer afflicted area, but also serves to reduce deleterious side effects that may be associated with the untargeted therapeutic moiety.

In another preferred embodiment, the lung cancer protein against which the antibodies are raised is an intracellular protein. In this case, the antibody may be conjugated to a protein or other entity which facilitates entry into the cell. In one case, the antibody enters the cell by endocytosis. In another embodiment, a nucleic acid encoding the antibody is administered to the individual or cell. Moreover, wherein the lung cancer protein can be targeted within a cell, i.e., the nucleus, an antibody theretomay contain a signal for that target localization, i.e., a nuclear localization signal. The lung cancer antibodies ofthe invention specifically bind to lung cancer proteins.

By "specifically bind" herein is meant that the antibodies bind to the protein with a K of at least about 0.1 mM, more usually at least about 1 μM, preferably at least about 0.1 μM or better, and most preferably, 0.01 μM or better. Selectivity of binding to the specific target and not to related other sequences is also important.

Detection of lung cancer sequence for diagnostic and therapeutic applications

In one aspect, the RNA expression levels of genes are determined for different cellular states in the lung cancer phenotype. Expression levels of genes in normal tissue (e.g., not undergoing lung cancer), in lung cancer tissue (and in some cases, for varying severities of lung cancer that relate to prognosis, as outlined below), or in non-malignant disease are evaluated to provide expression profiles. A gene expression profile of a particular cell state or point of development is essentially a "fingeφrint" ofthe state ofthe cell. While two states may have a particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is reflective ofthe state ofthe cell. By comparing expression profiles of cells in different states, information regarding which genes are important (including both up- and down-regulation of genes) in each of these states is obtained. Then, diagnosis may be performed or confirmed to determine whether a tissue sample has the gene expression profile of normal or cancerous tissue. This will provide for molecular diagnosis of related conditions. "Differential expression," or grammatical equivalents as used herein, refers to qualitative or quantitative differences in the temporal and/or cellular gene expression patterns within and among cells and tissue. Thus, a differentially expressed gene can qualitatively have its expression altered, including an activation or inactivation, in, e.g., normal versus lung cancer tissue. Genes may be turned on or turned off in a particular state, relative to another state thus permitting comparison of two or more states. A qualitatively regulated gene will exhibit an expression pattern within a state or cell type which is detectable by standard techniques. Some genes will be expressed in one state or cell type, but not in both. Alternatively, the difference in expression may be quantitative, e.g., in that expression is increased or decreased; i.e., gene expression is either upregulated, resulting in an increased amount of transcript, or downregulated, resulting in a decreased amount of transcript. The degree to which expression differs need only be large enough to quantify via standard characterization techniques as outlined below, such as by use of Affymetrix GeneChip™ expression arrays, Lockhart (1996) Nature Biotechnology 14: 1675-1680, hereby expressly incoφorated by reference. Other techniques include, but are not limited to, quantitative reverse transcriptase PCR, northern analysis and RNase protection. As outlined above, preferably the change in expression (i.e., upregulation or downregulation) is typically at least about 50%, more preferably at least about 100%, more preferably at least about 150%, more preferably at least about 200%, with from 300 to at least 1000% being especially preferred.

Evaluation may be at the gene transcript or the protein level. The amount of gene expression may be monitored using nucleic acid probes to the RNA or DNA equivalent ofthe gene transcript, and the quantification of gene expression levels, or, alternatively, the final gene product itself (protein) can be monitored, e.g., with antibodies to the lung cancer protein and standard immunoassays (ELISAs, etc.) or other techniques, including mass spectroscopy assays, 2D gel electrophoresis assays, etc. Proteins corresponding to lung cancer genes, e.g., those identified as being important in a lung cancer or disease phenotype, can be evaluated in a lung cancer diagnostic test. In a preferred embodiment, gene expression monitoring is performed simultaneously on a number of genes.

The lung cancer nucleic acid probes may be attached to biochips as outlined herein for the detection and quantification of lung cancer sequences in a particular cell. The assays are further described below in the example. PCR techniques can be used to provide greater sensitivity. Multiple protein expression monitoring can be performed as well. Similarly, these assays may be performed on an individual basis as well.

In a preferred embodiment nucleic acids encoding the lung cancer protein are detected. Although DNA or RNA encoding the lung cancer protem may be detected, of particular interest are methods wherein an mRNA encoding a lung cancer protein is detected. Probes to detect mRNA can be a nucleotide/deoxynucleotide probe that is complementary to and hybridizes with the mRNA and includes, but is not limited to, oligonucleotides, cDNA or RNA. Probes also should contain a detectable label, as defined herein. In one method the mRNA is detected after immobilizing the nucleic acid to be examined on a solid support such as nylon membranes and hybridizing the probe with the sample. Following washing to remove the non-specifically bound probe, the label is detected. In another method detection ofthe mRNA is performed in situ. In this method permeabilized cells or tissue samples are contacted with a detectably labeled nucleic acid probe for sufficient time to allow the probe to hybridize with the target mRNA. Following washing to remove the non-specifically bound probe, the label is detected. For example a digoxygenin labeled riboprobe (RNA probe) that is complementary to the mRNA encoding a lung cancer protein is detected by binding the digoxygenin with an anti-digoxygenin secondary antibody and developed with nitro blue tetrazolium and 5-bromo-4-chloro-3-indoyl phosphate.

In a preferred embodiment, various proteins from the three classes of proteins as described herein (secreted, transmembrane or intracellular proteins) are used in diagnostic assays. The lung cancer proteins, antibodies, nucleic acids, modified proteins and cells containing lung cancer sequences are used in diagnostic assays. This can be performed on an individual gene or corresponding polypeptide level. In a preferred embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes and/or corresponding polypeptides.

As described and defined herein, lung cancer proteins, including intracellular, transmembrane, or secreted proteins, find use as markers of lung cancer, e.g., for prognostic or diagnostic puφoses. Detection of these proteins in putative lung cancer tissue allows for detection, prognosis, or diagnosis of lung cancer or similar disease, and perhaps for selection of therapeutic strategy. In one embodiment, antibodies are used to detect lung cancer proteins. A preferred method separates proteins from a sample by electrophoresis on a gel (typically a denaturing and reducing protein gel, but may be another type of gel, including isoelectric focusing gels and the like). Following separation of proteins, the lung cancer protein is detected, e.g., by immunoblotting with antibodies raised against the lung cancer protein. Methods of immunoblotting are well known to those of ordinary skill in the art.

In another preferred method, antibodies to the lung cancer protein find use in in situ imaging techniques, e.g., in histology (e.g., Asai (ed. 1993) Methods in Cell Biology: Antibodies in Cell Biology, volume 37. In this method cells are contacted with from one to many antibodies to the lung cancer protein(s). Following washing to remove non-specific antibody binding, the presence ofthe antibody or antibodies is detected. In one embodiment the antibody is detected by incubating with a secondary antibody that contains a detectable label, e.g., multicolor fluorescence or confocal imaging. In another method the primary antibody to the lung cancer protein(s) contains a detectable label, e.g., an enzyme marker that can act on a substrate. In another preferred embodiment each one of multiple primary antibodies contains a distinct and detectable label. This method finds particular use in simultaneous screening for a plurality of lung cancer proteins. Many other histological imaging techniques are also provided by the invention.

In a preferred embodiment the label is detected in a fluorometer which has the ability to detect and distinguish emissions of different wavelengths. In addition, a fluorescence activated cell sorter (FACS) can be used in the method.

In another preferred embodiment, antibodies find use in diagnosing lung cancer from blood, serum, plasma, stool, and other samples. Such samples, therefore, are useful as samples to be probed or tested for the presence of lung cancer proteins. Antibodies can be used to detect a lung cancer protein by previously described immunoassay techniques including ELISA, immunoblotting (western blotting), immunoprecipitation, BIACORE technology and the like. Conversely, the presence of antibodies may indicate an immune response against an endogenous lung cancer protein or vaccine.

In a preferred embodiment, in situ hybridization of labeled lung cancer nucleic acid probes to tissue arrays is done. For example, arrays of tissue samples, including lung cancer tissue and/or normal tissue, are made. In situ hybridization (see, e.g., Ausubel, supra) is then performed. When comparing the fingeφrints between an individual and a standard, the skilled artisan can make a diagnosis, a prognosis, or a prediction based on the findings. It is further understood that the genes which indicate the diagnosis may differ from those which indicate the prognosis and molecular profiling ofthe condition ofthe cells may lead to distinctions between responsive or refractory conditions or may be predictive of outcomes.

In a preferred embodiment, the lung cancer proteins, antibodies, nucleic acids, modified proteins and cells containing lung cancer sequences are used in prognosis assays.

)

As above, gene expression profiles can be generated that correlate to lung cancer, clinical, pathological, or other information, in terms of long term prognosis. Again, this may be done on either a protein or gene level, with the use of genes being preferred. Single or multiple genes may be useful in various combinations. As above, lung cancer probes may be attached to biochips for the detection and quantification of lung cancer sequences in a tissue or patient. The assays proceed as outlined above for diagnosis. PCR method may provide more sensitive and accurate quantification.

Assays for therapeutic compounds

In a preferred embodiment, the proteins, nucleic acids, and antibodies as described herein are used in drug screening assays. The lung cancer proteins, antibodies, nucleic acids, modified proteins and cells containing lung cancer sequences are used in drug screening assays or by evaluating the effect of drug candidates on a "gene expression profile" or expression profile of polypeptides. In a preferred embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes after freatment with a candidate agent (e.g., Zlokarnik, et al. (1998) Science 279:84-8; Heid (1996) Genome Res. 6:986-94. In a preferred embodiment, the lung cancer proteins, antibodies, nucleic acids, modified proteins and cells containing the native or modified lung cancer proteins are used in screening assays. That is, the present invention provides novel methods for screening for compositions which modulate the lung cancer phenotype or an identified physiological function of a lung cancer protein. As above, this can be done on an individual gene level or by evaluating the effect of drag candidates on a "gene expression profile". In a preferred embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes after treatment with a candidate agent, see Zlokarnik, supra.

Having identified differentially expressed genes herein, a variety of assays may be performed. In a preferred embodiment, assays may be ran on an individual gene or protein level. That is, having identified a particular gene with altered regulation in lung cancer, test compounds can be screened for the ability to modulate gene expression or for binding to the lung cancer protein. "Modulation" thus includes an increase or a decrease in gene expression. The preferred amount of modulation will depend on the original change ofthe gene expression in normal versus tissue undergoing lung cancer, with changes of at least 10%, preferably 50%, more preferably 100-300%, and in some embodiments 300-1000%) or greater. Thus, if a gene exhibits a 4-fold increase in lung cancer tissue compared to normal tissue, a decrease of about four-fold is often desired; similarly, a 10-fold decrease in lung cancer tissue compared to normal tissue often provides a target value of a 10-fold increase in expression to be induced by the test compound.

The amount of gene expression may be monitored using nucleic acid probes and the quantification of gene expression levels, or, alternatively, the gene product itself can be monitored, e.g., through the use of antibodies to the lung cancer protein and standard immunoassays. Proteomics and separation techniques may also allow quantification of expression.

In a preferred embodiment, gene or protein expression monitoring of a number of entities, i.e., an expression profile, is monitored simultaneously. Such profiles will typically involve a plurality of those entities described herein.

In this embodiment, the lung cancer nucleic acid probes are attached to biochips as outlined herein for the detection and quantification of lung cancer sequences in a particular cell. Alternatively, PCR may be used. Thus, a series, e.g., of microtiter plate, may be used with dispensed primers in desired wells. A PCR reaction can then be performed and analyzed for each well.

Expression monitoring can be performed to identify compounds that modify the expression of one or more lung cancer-associated sequences, e.g., a polynucleotide sequence set out in the tables. Generally, in a preferred embodiment, a test compound is added to the cells prior to analysis. Moreover, screens are also provided to identify agents that modulate lung cancer, modulate lung cancer proteins, bind to a lung cancer protein, or interfere with the binding of a lung cancer protein and an antibody, substrate, or other binding partner.

The term "test compound" or "drag candidate" or "modulator" or grammatical equivalents as used herein describes a molecule, e.g., protein, oligopeptide, small organic molecule, polysaccharide, polynucleotide, etc., to be tested for the capacity to directly or. indirectly alter the lung cancer phenotype or the expression of a lung cancer sequence, e.g., a nucleic acid or protein sequence. In preferred embodiments, modulators alter expression profiles of nucleic acids or proteins provided herein. In one embodiment, the modulator suppresses a lung cancer phenotype, e.g., to a normal or non-malignant tissue fingeφrint. In another embodiment, a modulator induces a lung cancer phenotype. Generally, a plurality of assay mixtures are run in parallel with different agent concentrations to obtain a differential response to the various concentrations. Typically, one of these concentrations serves as a negative control, i.e., at zero concentration or below the level of detection. In one aspect, a modulator will neutralize the effect of a lung cancer protein. By "neutralize" is meant that activity of a protein and the consequent effect on the cell is inhibited or blocked.

In certain embodiments, combinatorial libraries of potential modulators will be screened for an ability to bind to a lung cancer polypeptide or to modulate activity.

Conventionally, new chemical entities with useful properties are generated by identifying a chemical compound (called a "lead compound") with some desirable property or activity, e.g., inhibiting activity, creating variants ofthe lead compound, and evaluating the property and activity of those variant compounds. Often, high throughput screening (HTS) methods are employed for such an analysis.

In one preferred embodiment, high throughput screening methods involve providing a library containing a large number of potential therapeutic compounds (candidate compounds). Such "combinatorial chemical libraries" are then screened in one or more assays to identify those library members (particular chemical species or subclasses) that display a desired characteristic activity. The compounds thus identified can serve as conventional "lead compounds" or can themselves be used as potential or actual therapeutics.

A combinatorial chemical library is a collection of diverse chemical compounds generated by either chemical synthesis or biological synthesis by combining a number of chemical "building blocks" such as reagents. For example, a linear combinatorial chemical library, such as a polypeptide (e.g., mutein) library, is formed by combining a set of chemical building blocks called amino acids in every possible way for a given compound length (i.e., the number of amino acids in a polypeptide compound). Millions of chemical compounds can be synthesized through such combinatorial mixing of chemical building blocks (Gallop, et al. (1994) J. Med. Chem. 37(9):1233-1251). Preparation and screening of combinatorial chemical libraries is well known to those of skill in the art. Such combinatorial chemical libraries include, but are not limited to, peptide libraries (see, e.g., U.S. Patent No. 5,010,175, Furka (1991) Pept. Prot. Res. 37:487- 493, Houghton, et al. (1991) Nature. 354:84-88), peptoids (PCT Publication No WO 91/19735), encoded peptides (PCT Publication WO 93/20242), random bio-oligomers (PCT Publication WO 92/00091), benzodiazepines (U.S. Pat. No. 5,288,514), diversomers such as hydantoins, benzodiazepines and dipeptides (Hobbs, et al. (1993) Proc. Nat. Acad. Sci. USA 90:6909-6913), vinylogous polypeptides (Hagihara, et al. (1992) J. Amer. Chem. Soc. 114:6568), nonpeptidal peptidomimetics with a Beta-D-Glucose scaffolding (Hirschmann, et al. (1992) J. Amer. Chem. Soc. 114:9217-9218), analogous organic syntheses of small compound libraries (Chen, et al. (1994) J. Amer. Chem. Soc. 116:2661), oligocarbamates (Cho, et al. (1993) Science 261:1303), and/or peptidyl phosphonates (Campbell, et al. (1994) J. Org. Chem. 59:658). See, generally, Gordon, et al. (1994) J. Med. Chem. 37:1385, nucleic acid libraries (see, e.g., Sfratagene, Coφ.), peptide nucleic acid libraries (see, e.g., U.S. Patent 5,539,083), antibody libraries (see, e.g., Vaughn, et al. (1996) Nature Biotechnology 14(3):309-314, and PCT/US96/10287), carbohydrate libraries (see, e.g., Liang, et al. (1996) Science 274:1520-1522, and U.S. Patent No. 5,593,853), and small organic molecule libraries (see, e.g., benzodiazepines, Baum (1993) C&EN, Jan 18, page 33; isoprenoids, U.S. Patent No. 5,569,588; thiazolidinones and metathiazanones, U.S. Patent No. 5,549,974; pyrrolidines, U.S. Patent Nos. 5,525,735 and 5,519,134; moφholino compounds, U.S. Patent No. 5,506,337; benzodiazepines, U.S. Patent No. 5,288,514; and the like).

Devices for the preparation of combinatorial libraries are commercially available (see, e.g., 357 MPS, 390 MPS, Advanced Chem Tech, Louisville KY, Symphony, Rainin, Woburn, MA, 433 A Applied Biosystems, Foster City, CA, 9050 Plus, MiUipore, Bedford, MA).

A number of well known robotic systems have also been developed for solution phase chemistries. These systems include automated workstations like the automated synthesis apparatus developed by Takeda Chemical Industries, LTD. (Osaka, Japan) and many robotic systems utilizing robotic arms (Zymate II, Zymark Coφoration, Hopkinton, Mass.; Orca,

Hewlett-Packard, Palo Alto, Calif), which mimic the manual synthetic operations performed by a chemist. The above devices, with appropriate modification, are suitable for use with the present invention. In addition, numerous combinatorial libraries are themselves commercially available (see, e.g., ComGenex, Princeton, N.J., Asinex, Moscow, Ru, Tripos, Inc., St. Louis, MO, ChemStar, Ltd, Moscow, RU, 3D Pharmaceuticals, Exton, PA, Martek Biosciences, Columbia, MD, etc.).

The assays to identify modulators are amenable to high throughput screening. Preferred assays thus detect modulation of lung cancer gene transcription, polypeptide expression, and polypeptide activity. High throughput assays for evaluating the presence, absence, quantification, or other properties of particular nucleic acids or protein products are well known to those of skill in the art. Similarly, binding assays and reporter gene assays are similarly well known. Thus, e.g., U.S. Patent No. 5,559,410 discloses high throughput screening methods for proteins, U.S. Patent No. 5,585,639 discloses high throughput screening methods for nucleic acid binding (i.e., in arrays), while U.S. Patent Nos. 5,576,220 and 5,541,061 disclose high throughput methods of screening for ligand/antibody binding.

In addition, high throughput screening systems are commercially available (see, e.g., Zymark Coφ., Hopkinton, MA; Air Technical Industries, Mentor, OH; Beckman

Instruments, Inc. Fullerton, CA; Precision Systems, Inc., Natick, MA, etc.). These systems typically automate procedures, including sample and reagent pipetting, liquid dispensing, timed incubations, and final readings ofthe microplate in detector(s) appropriate for the assay. These configurable systems provide high throughput and rapid start up as well as a high degree of flexibility and customization. The manufacturers of such systems provide detailed protocols for various high throughput systems. Thus, e.g., Zymark Coφ. provides technical bulletins describing screening systems for detecting the modulation of gene transcription, ligand binding, and the like.

In one embodiment, modulators are proteins, often naturally occurring proteins or fragments of naturally occurring proteins. Thus, e.g., cellular extracts containing proteins, or random or directed digests of proteinaceous cellular extracts, may be used. In this way libraries of proteins may be made for screening in the methods ofthe invention. Particularly preferred in this embodiment are libraries of bacterial, fungal, viral, and mammalian proteins, with the latter being preferred, and human proteins being especially preferred. Particularly useful test compound will be directed to the class of proteins to which the target belongs, e.g., substrates for enzymes or ligands and receptors.

In a preferred embodiment, modulators are peptides of from about 5 to about 30 amino acids, with from about 5 to about 20 amino acids being preferred, and from about 7 to about 15 being particularly preferred. The peptides may be digests of naturally occurring proteins, random peptides, or "biased" random peptides. By "randomized" or grammatical equivalents herein is meant that the nucleic acid or peptide consists of essentially random sequences of nucleotides and amino acids, respectively. Since these random peptides (or nucleic acids, discussed below) are often chemically synthesized, they may incoφorate a nucleotide or amino acid at any position. The synthetic process can be designed to generate randomized proteins or nucleic acids, to allow the formation of all or most ofthe possible combinations over the length ofthe sequence, thus forming a library of randomized candidate bioactive proteinaceous agents. In one embodiment, the library is fully randomized, with no sequence preferences or constants at any position. In a preferred embodiment, the library is biased. That is, some positions within the sequence are either held constant, or are selected from a limited number of possibilities. In a preferred embodiment, the nucleotides or amino acid residues are randomized within a defined class, e.g., of hydrophobic amino acids, hydrophilic residues, sterically biased (either small or large) residues, towards the creation of nucleic acid binding domains, the creation of cysteines, for cross-linking, prolines for SH-3 domains, serines, threonines, tyrosines or histidines for phosphorylation sites, etc.

Modulators of lung cancer can also be nucleic acids, as defined above. As described above generally for proteins, nucleic acid modulating agents may be naturally occurring nucleic acids, random nucleic acids, or "biased" random nucleic acids. Digests of procaryotic or eucaryotic genomes may be used as is outlined above for proteins.

In a preferred embodiment, the candidate compounds are organic chemical moieties, a wide variety of which are available in the literature. After a candidate agent has been added and the cells allowed to incubate for some period of time, the sample containing a target sequence is analyzed. If required, the target sequence is prepared using known techniques. For example, the sample may be treated to lyse the cells, using known lysis buffers, elecfroporation, etc., with purification and/or amplification such as PCR performed as appropriate. For example, an in vitro transcription with labels covalently attached to the nucleotides is performed. Generally, the nucleic acids are labeled with biotin-FITC or PE, or with cy3 or cy5.

In a preferred embodiment, the target sequence is labeled with, e.g., a fluorescent, a chemiluminescent, a chemical, or a radioactive signal, to provide a means of detecting the target sequence's specific binding to a probe. The label also can be an enzyme, such as, alkaline phosphatase or horseradish peroxidase, which when provided with an appropriate substrate produces a product that can be detected. Alternatively, the label can be a labeled compound or small molecule, such as an enzyme inhibitor, that binds but is not catalyzed or altered by the enzyme. The label also can be a moiety or compound, such as, an epitope tag or biotin which specifically binds to streptavidin. For the example of biotin, the streptavidin is labeled as described above, thereby, providing a detectable signal for the bound target sequence. Unbound labeled streptavidin is typically removed prior to analysis.

Nucleic acid assays can be direct hybridization assays or can comprise "sandwich assays", which include the use of multiple probes, as is generally outlined in U.S. Patent Nos. 5,681,702, 5,597,909, 5,545,730, 5,594,117, 5,591,584, 5,571,670, 5,580,731, 5,571,670, 5,591,584, 5,624,802, 5,635,352, 5,594,118, 5,359,100, 5,124,246 and 5,681,697, all of which are hereby incoφorated by reference. In this embodiment, in general, the target nucleic acid is prepared as outlined above, and then added to the biochip comprising a plurality of nucleic acid probes, under conditions that allow the formation of a hybridization complex.

A variety of hybridization conditions may be used in the present invention, including high, moderate and low stringency conditions as outlined above. The assays are generally run under stringency conditions which allow formation ofthe label probe hybridization complex only in the presence of target. Stringency can be controlled by altering a step parameter that is a thermodynamic variable, including, but not limited to, temperature, formamide concentration, salt concentration, chaofropic salt concentration, pH, organic solvent concentration, etc.

These parameters may also be used to control non-specific binding, as is generally outlined in U.S. Patent No. 5,681,697. Thus it may be desirable to perform certain steps at higher stringency conditions to reduce non-specific binding.

The reactions outlined herein may be accomplished in a variety of ways. Components ofthe reaction may be added simultaneously, or sequentially, in different orders, with preferred embodiments outlined below. In addition, the reaction may include a variety of other reagents. These include salts, buffers, neutral proteins, e.g., albumin, detergents, etc. which may be used to facilitate optimal hybridization and detection, and/or reduce nonspecific or background interactions. Reagents that otherwise improve the efficiency ofthe assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may also be used as appropriate, depending on the sample preparation methods and purity ofthe target.

The assay data are analyzed to determine the expression levels, and changes in expression levels as between states, of individual genes, forming a gene expression profile.

Screens are performed to identify modulators ofthe lung cancer phenotype. In one embodiment, screening is performed to identify modulators that can induce or suppress a particular expression profile, thus preferably generating the associated phenotype. In another embodiment, e.g., for diagnostic applications, having identified differentially expressed genes important in a particular state, screens can be performed to identify modulators that alter expression of individual genes. In an another embodiment, screening is performed to identify modulators that alter a biological function ofthe expression product of a differentially expressed gene. Again, having identified the importance of a gene in a particular state, screens are performed to identify agents that bind and/or modulate the biological activity of the gene product, or evaluate genetic polymoφhisms.

Genes can be screened for those that are induced in response to a candidate agent. After identifying a modulator based upon its ability to suppress a lung cancer expression pattern leading to a normal expression pattern, or to modulate a single lung cancer gene expression profile so as to mimic the expression ofthe gene from normal tissue, a screen as described above can be performed to identify genes that are specifically modulated in response to the agent. Comparing expression profiles between normal tissue and agent treated lung cancer tissue reveals genes that are not expressed in normal tissue or lung cancer tissue, but are expressed in agent treated tissue. These agent-specific sequences can be identified and used by methods described herein for lung cancer genes or proteins. In particular these sequences and the proteins they encode find use in marking or identifying agent treated cells. In addition, antibodies can be raised against the agent induced proteins and used to target novel therapeutics to the treated lung cancer tissue sample. Thus, in one embodiment, a test compound is administered to a population of lung cancer cells, that have an associated lung cancer expression profile. By "adminisfration" or "contacting" herein is meant that the candidate agent is added to the cells in such a manner as to allow the agent to act upon the cell, whether by uptake and intracellular action, or by action at the cell surface. In some embodiments, nucleic acid encoding a proteinaceous candidate agent (i.e., a peptide) may be put into a viral construct such as an adenoviral or retroviral construct, and added to the cell, such that expression ofthe peptide agent is accomplished, e.g., PCT US97/01019; Regulatable gene therapy systems can also be used. Once a test compound has been administered to the cells, the cells can be washed if desired and are allowed to incubate under preferably physiological conditions for some period of time. The cells are then harvested and a new gene expression profile is generated, as outlined herein.

Thus, e.g., lung cancer or non-malignant tissue may be screened for agents that modulate, e.g., induce or suppress a lung cancer phenotype. A change in at least one gene, preferably many, ofthe expression profile indicates that the agent has an effect on lung cancer activity. By defining such a signature for the lung cancer phenotype, screens for new drugs that alter the phenotype can be devised. With this approach, the drug target need not be known and need not be represented in the original expression screening platform, nor does the level of transcript for the target protein need to change. Measure of lung cancer polypeptide activity, or of lung cancer or the lung cancer phenotype can be performed using a variety of assays. For example, the effects ofthe test compounds upon the function ofthe metastatic polypeptides can be measured by examining parameters described above. A suitable physiological change that affects activity can be used to assess the influence of a test compound on the polypeptides of this invention. When the functional consequences are determined using intact cells or animals, one can also measure a variety of effects such as, in the case of lung cancer associated with tumors, tumor growth, tumor metastasis, neovascularization, hormone release, transcriptional changes to both known and uncharacterized genetic markers (e.g., northern blots), changes in cell metabolism such as cell growth or pH changes, and changes in intracellular second messengers such as cGMP. In the assays ofthe invention, mammalian lung cancer polypeptide is typically used, e.g., mouse, preferably human.

Assays to identify compounds with modulating activity can be performed in vitro. For example, a lung cancer polypeptide is first contacted with a potential modulator and incubated for a suitable amount of time, e.g., from 0.5 to 48 hours. In one embodiment, the lung cancer polypeptide levels are determined in vitro by measuring the level of protein or mRNA. The level of protein is typically measured using immunoassays such as western blotting, ELISA and the like with an antibody that selectively binds to the lung cancer polypeptide or a fragment thereof. For measurement of mRNA, amplification, e.g., using PCR, LCR, or hybridization assays, e.g., northern hybridization, RNAse protection, dot blotting, are preferred. The level of protein or mRNA is typically detected using directly or indirectly labeled detection agents, e.g., fluorescentiy or radioactively labeled nucleic acids, radioactively or enzymatically labeled antibodies, and the like, as described herein.

Alternatively, a reporter gene system can be devised using a lung cancer protein promoter operably linked to a reporter gene such as luciferase, green fluorescent protein, CAT, or β-gal. The reporter construct is typically transfected into a cell. After treatment with a potential modulator, the amount of reporter gene franscription, translation, or activity is measured according to standard techniques known to those of skill in the art.

In a preferred embodiment, as outlined above, screens may be done on individual genes and gene products (proteins). That is, having identified a particular differentially expressed gene as important in a particular state, screening of modulators ofthe expression of the gene or the gene product itself can be done. The gene products of differentially expressed genes are sometimes referred to herein as "lung cancer proteins." The lung cancer protein may be a fragment, or alternatively, be the full length protein to a fragment shown herein.

In one embodiment, screening for modulators of expression of specific genes is performed. Typically, the expression of only one or a few genes are evaluated. In another embodiment, screens are designed to first find compounds that bind to differentially expressed proteins. These compounds are then evaluated for the ability to modulate differentially expressed activity. Moreover, once initial candidate compounds are identified, variants can be further screened to better evaluate stracture activity relationships.

In a preferred embodiment, binding assays are done. In general, purified or isolated gene product is used; that is, the gene products of one or more differentially expressed nucleic acids are made. For example, antibodies are generated to the protein gene products, and standard immunoassays are run to determine the amount of protein present. Alternatively, cells comprising the lung cancer proteins can be used in the assays.

Thus, in a preferred embodiment, the methods comprise combining a lung cancer protein and a candidate compound, and determining the binding ofthe compound to the lung cancer protein. Preferred embodiments utilize the human lung cancer protein, although other mammalian proteins may also be used, e.g., for the development of animal models of human disease. In some embodiments, as outlined herein, variant or derivative lung cancer proteins may be used. Generally, in a preferred embodiment ofthe methods herein, the lung cancer protein or the candidate agent is non-diffusably bound to an insoluble support, preferably having isolated sample receiving areas (e.g., a microtiter plate, an array, etc.). The insoluble supports may be made of a composition to which the compositions can be bound, is readily separated from soluble material, and is otherwise compatible with the overall method of screening. The surface of such supports may be solid or porous and of a convenient shape. Examples of suitable insoluble supports include microtiter plates, arrays, membranes and beads. These are typically made of glass, plastic (e.g., polystyrene), polysaccharides, nylon or nitrocellulose, teflon™, etc. Microtiter plates and arrays are especially convenient because a large number of assays can be carried out simultaneously, using small amounts of reagents and samples. The particular manner of binding ofthe composition is typically not cracial so long as it is compatible with the reagents and overall methods ofthe invention, maintains the activity ofthe composition, and is nondiffusable. Preferred methods of binding include the use of antibodies (which do not sterically block either the ligand binding site or activation sequence when the protein is bound to the support), direct binding to "sticky" or ionic supports, chemical crosslinking, the synthesis ofthe protein or agent on the surface, etc. Following binding ofthe protein or agent, excess unbound material is removed by washing. The sample receiving areas may then be blocked through incubation with bovine serum albumin (BSA), casein or other innocuous protein or other moiety.

In a preferred embodiment, the lung cancer protein is bound to the support, and a test compound is added to the assay. Alternatively, the candidate agent is bound to the support and the lung cancer protein is added. Novel binding agents include specific antibodies, non- natural binding agents identified in screens of chemical libraries, peptide analogs, etc. Of particular interest are screening assays for agents that have a low toxicity for human cells. A wide variety of assays may be used for this puφose, including labeled in vitro protein-protein binding assays, electrophoretic mobility shift assays, immunoassays for protem binding, functional assays (phosphorylation assays, etc.) and the like.

The determination ofthe binding ofthe test modulating compound to the lung cancer protein may be done in a number of ways. In a preferred embodiment, the compound is labeled, and bmding determined directly, e.g., by attaching all or a portion ofthe lung cancer protein to a solid support, adding a labeled candidate agent (e.g., a fluorescent label), washing off excess reagent, and determining whether the label is present on the solid support. Various blocking and washing steps may be utilized as appropriate. In some embodiments, only one ofthe components is labeled, e.g., the proteins (or proteinaceous candidate compounds) can be labeled. Alternatively, more than one component can be labeled with different labels, e.g., ¹²⁵I for the proteins and a fluorophor for the compound. Proximity reagents, e.g., quenching or energy transfer reagents are also useful. In one embodiment, the binding ofthe test compound is determined by competitive binding assay. The competitor may be a binding moiety known to bind to the target molecule (i.e., a lung cancer protein), such as an antibody, peptide, binding partner, ligand, etc. Under certain circumstances, there may be competitive binding between the compound and the binding moiety, with the binding moiety displacing the compound. In one embodiment, the test compound is labeled. Either the compound, or the competitor, or both, is added first to the protein for a time sufficient to allow binding, if present. Incubations may be performed at a temperature which facilitates optimal activity, typically between 4 and 40° C. Incubation periods are typically optimized, e.g., to facilitate rapid high throughput screening. Typically between 0.1 and 1 hour will be sufficient. Excess reagent is generally removed or washed away. The second component is then added, and the presence or absence ofthe labeled component is followed, to indicate binding.

In a preferred embodiment, the competitor is added first, followed by a test compound. Displacement ofthe competitor is an indication that the test compound is binding to the lung cancer protein and thus is capable of binding to, and potentially modulating, the activity ofthe lung cancer protein. In this embodiment, either component can be labeled. Thus, e.g., if the competitor is labeled, the presence of label in the wash solution indicates displacement by the agent. Alternatively, if the test compound is labeled, the presence ofthe label on the support indicates displacement.

In an alternative embodiment, the test compound is added first, with incubation and washing, followed by the competitor. The absence of binding by the competitor may indicate that the test compound is bound to the lung cancer protein with a higher affinity. Thus, if the test compound is labeled, the presence ofthe label on the support, coupled with a lack of - competitor binding, may indicate that the test compound is capable of binding to the lung cancer protein.

In a preferred embodiment, the methods comprise differential screening to identity agents that are capable of modulating the activity ofthe lung cancer proteins. In one embodiment, the methods comprise combining a lung cancer protein and a competitor in a first sample. A second sample comprises a test compound, a lung cancer protein, and a competitor. The binding ofthe competitor is determined for both samples, and a change, or difference in binding between the two samples indicates the presence of an agent capable of binding to the lung cancer protein and potentially modulating its activity. That is, if the binding ofthe competitor is different in the second sample relative to the first sample, the agent is capable of binding to the lung cancer protein.

Alternatively, differential screening is used to identify drag candidates that bind to the native lung cancer protein, but cannot bind to modified lung cancer proteins. The stracture of the lung cancer protein may be modeled, and used in rational drag design to synthesize agents that interact with that site. Drug candidates that affect the activity of a lung cancer protein are also identified by screening drugs for the ability to either enhance or reduce the activity of the protein.

Positive controls and negative controls may be used in the assays. Preferably confrol and test samples are performed in at least triplicate to obtain statistically significant results. Incubation of all samples is for a time sufficient for the binding ofthe agent to the protein. Following incubation, samples are washed free of non-specifically bound material and the amount of bound, generally labeled agent determined. For example, where a radiolabel is employed, the samples may be counted in a scintillation counter to determine the amount of bound compound.

A variety of other reagents may be included in the screening assays. These include reagents like salts, neutral proteins, e.g., albumin, detergents, etc. which may be used to facilitate optimal protein-protein binding and/or reduce non-specific or background interactions. Also reagents that otherwise improve the efficiency ofthe assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may be used. The mixture of components may be added in an order that provides for the requisite binding.

In a preferred embodiment, the invention provides methods for screening for a compound capable of modulating the activity of a lung cancer protein. The methods comprise adding a test compound, as defined above, to a cell comprising lung cancer proteins. Preferred cell types include almost any cell. The cells contain a recombinant nucleic acid that encodes a lung cancer protein. In a preferred embodiment, a library of candidate agents are tested on a plurality of cells.

In one aspect, the assays are evaluated in the presence or absence or previous or subsequent exposure of physiological signals, e.g., hormones, antibodies, peptides, antigens, cytokines, growth factors, action potentials, pharmacological agents including chemotherapeutics, radiation, carcinogenics, or other cells (e.g., cell-cell contacts). In another example, the determinations are determined at different stages ofthe cell cycle process.

In this way, compounds that modulate lung cancer agents are identified. Compounds with pharmacological activity are able to enhance or interfere with the activity ofthe lung cancer protein. Once identified, similar stractures are evaluated to identify critical stractural feature ofthe compound.

In one embodiment, a method of inhibiting lung cancer cell division is provided. The method comprises administration of a lung cancer inhibitor. In another embodiment, a method of inhibiting lung cancer is provided. The method may comprise adminisfration of a lung cancer inhibitor. In a further embodiment, methods of treating cells or individuals with lung cancer are provided, e.g., comprising administration of a lung cancer inhibitor.

In one embodiment, a lung cancer inhibitor is an antibody as discussed above. In another embodiment, the lung cancer inhibitor is an antisense molecule. A variety of cell growth, proliferation, viability, and metastasis assays are known to those of skill in the art, as described below.

Soft agar growth or colony formation in suspension Normal cells require a solid substrate to attach and grow. When the cells are transformed, they lose this phenotype and grow detached from the substrate. For example, transformed cells can grow in stirred suspension culture or suspended in semi-solid media, such as semi-solid or soft agar. The transformed cells, when transfected with tumor suppressor genes, regenerate normal phenotype and require a solid subsfrate to attach and grow. Soft agar growth or colony formation in suspension assays can be used to identify modulators of lung cancer sequences, which when expressed in host cells, inhibit abnormal cellular proliferation and transformation. A therapeutic compound would reduce or eliminate the host cells' ability to grow in stirred suspension culture or suspended in semi-solid media, such as semi-solid or soft. Techniques for soft agar growth or colony formation in suspension assays are described in Freshney (1994) Culture of Animal Cells a Manual of Basic Technique (3^rd ed.), herein incoφorated by reference. See also, the methods section of Garkavtsev, et al. (1996), supra, herein incoφorated by reference.

Contact inhibition and density limitation of growth

Normal cells typically grow in a flat and organized pattern in a petri dish until they touch other cells. When the cells touch one another, they are contact inhibited and stop growing. When cells are transformed, however, the cells are not contact inhibited and continue to grow to high densities in disorganized foci. Thus, the transformed cells grow to a higher saturation density than normal cells. This can be detected moφhologically by the formation of a disoriented monolayer of cells or rounded cells in foci within the regular pattern of normal surrounding cells. Alternatively, labeling index with ( H)-thymιdine at saturation density can be used to measure density limitation of growth. See Freshney (1994), supra. The transformed cells, when transfected with tumor suppressor genes, regenerate a normal phenotype and become contact inhibited and would grow to a lower density.

In this assay, labeling index with ( H)-thymidine at saturation density is a preferred method of measuring density limitation of growth. Transformed host cells are fransfected with a lung cancer-associated sequence and are grown for 24 hours at saturation density in non-limiting medium conditions. The percentage of cells labeling with (³H)-thymidine is determined autoradiographically. See, Freshney (1994), supra.

Growth factor or serum dependence

Transformed cells typically have a lower serum dependence than their normal counteφarts (see, e.g., Temin (1966) J. Natl. Cancer Insti. 37:167-175; Eagle, et al. (1970) __ Exp. Med. 131:836-879); Freshney, supra. This is in part due to release of various growth factors by the transformed cells. Growth factor or serum dependence of transformed host cells can be compared with that of control.

Tumor specific markers levels

Tumor cells release an increased amount of certain factors (hereinafter "tumor specific markers") than their normal counteφarts. For example, plasminogen activator (PA) is released from human glioma at a higher level than from normal brain cells (see, e.g., Gullino, "Angiogenesis, tumor vascularization, and potential interference with tumor growth" in Mihich (ed. 1985) Biological Responses in Cancer, pp. 178-184). Similarly, Tumor angiogenesis factor (TAF) is released at a higher level in tumor cells than their normal counteφarts. See, e.g., Folkman (1992) "Angiogenesis and Cancer" in Sem Cancer Biol.). Various techniques which measure the release of these factors are described in Freshney (1994), supra. Also, see, Unkeless, et al. (1974) J. Biol. Chem. 249:4295-4305; Strickland and Beers (1976) J. Biol. Chem. 251:5694-5702; Whur, et al. (1980) Br. J. Cancer 42:305-312; Gullino, "Angiogenesis, tumor vascularization, and potential interference with tumor growth" in Mihich (ed. 1985) Biological Responses in Cancer, pp. 178-184; Freshney Anticancer Res. 5:111-130 (1985).

Invasiveness into Matrigel

The degree of invasiveness into Matrigel or some other exfracellular matrix constituent can be used as an assay to identify compounds that modulate lung cancer- associated sequences. Tumor cells exhibit a good correlation between malignancy and invasiveness of cells into Matrigel or some other extracellular matrix constituent. In this assay, tumorigenic cells are typically used as host cells. Expression of a tumor suppressor gene in these host cells would decrease invasiveness ofthe host cells. Techniques described in Freshney (1994), supra, can be used. Briefly, the level of invasion of host cells can be measured by using filters coated with Matrigel or some other extracellular matrix constituent. Penetration into the gel, or through to the distal side ofthe filter, is rated as invasiveness, and rated histologically by number of cells and distance

1 moved, or by prelabeling the cells with I and counting the radioactivity on the distal side of the filter or bottom ofthe dish. See, e.g., Freshney (1984), supra.

Tumor growth in vivo

Effects of lung cancer-associated sequences on cell growth can be tested in transgenic or immune-suppressed mice. Knock-out transgenic mice can be made, in which the lung cancer gene is disrupted or in which a lung cancer gene is inserted. Knock-out fransgenic mice can be made by insertion of a marker gene or other heterologous gene into the endogenous lung cancer gene site in the mouse genome via homologous recombination. Such mice can also be made by substituting the endogenous lung cancer gene with a mutated version ofthe lung cancer gene, or by mutating the endogenous lung cancer gene, e.g., by exposure to carcinogens.

A DNA construct is introduced into the nuclei of embryonic stem cells. Cells containing the newly engineered genetic lesion are injected into a host mouse embryo, which is re-implanted into a recipient female. Some of these embryos develop into chimeric mice that possess germ cells partially derived from the mutant cell line. Therefore, by breeding the chimeric mice it is possible to obtain a new line of mice containing the introduced genetic lesion (see, e.g., Capecchi, et al. (1989) Science 244:1288). Chimeric targeted mice can be derived according to Hogan, et al. (1988) Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory and Robertson (ed. 1987) Teratocarcinomas and Embryonic Stem Cells: A Practical Approach. , IRL Press, Washington, D.C.

Alternatively, various immune-suppressed or immune-deficient host animals can be used. For example, genetically athymic "nude" mouse (see, e.g., Giovanella, et al. (1974) Natl. Cancer Inst. 52:921), a SCID mouse, a thymectomized mouse, or an irradiated mouse (see, e.g., Bradley, et al. (1978) Br. J. Cancer 38:263; Selby, et al. (1980) Br. J. Cancer 41:52) can be used as a host. Transplantable tumor cells (typically about 10⁶ cells) injected into isogenic hosts will produce invasive tumors in a high proportions of cases, while normal cells of similar origin will not. In hosts which developed invasive tumors, cells expressing a lung cancer-associated sequences are injected subcutaneously. After a suitable length of time, preferably 4-8 weeks, tumor growth is measured (e.g., by volume or by its two largest dimensions) and compared to the control. Tumors that have statistically significant reduction (using, e.g., Student's T test) are said to have inhibited growth.

Polynucleotide modulators of lung cancer

Antisense and RNAi Polynucleotides

In certain embodiments, the activity of a lung cancer-associated protein is downregulated, or entirely inhibited, by the use of antisense or an inhibitory polynucleotide, i.e., a nucleic acid complementary to, and which can preferably hybridize specifically to, a coding mRNA nucleic acid sequence, e.g., a lung cancer protein mRNA, or a subsequence thereof. Binding ofthe antisense polynucleotide to the mRNA reduces the franslation and/or stability ofthe mRNA.

In the context of this invention, antisense polynucleotides can comprise naturally- occurring nucleotides, or synthetic species formed from naturally-occurring subunits or their close homologs. Antisense polynucleotides may also have altered sugar moieties or inter- sugar linkages. Exemplary among these are the phosphorothioate and other sulfur containing species which are known for use in the art. Analogs are comprehended by this invention so long as they function effectively to hybridize with the lung cancer protein mRNA. See, e.g., Isis Pharmaceuticals, Carlsbad, CA; Sequitor, Inc., Natick, MA. Such antisense polynucleotides can readily be synthesized using recombinant means, or can be synthesized in vitro. Equipment for such synthesis is sold by several vendors, including Applied Biosystems. The preparation of other oligonucleotides such as phosphorothioates and alkylated derivatives is also well known to those of skill in the art. Antisense molecules as used herein include antisense or sense oligonucleotides. Sense oligonucleotides can, e.g., be employed to block franscription by binding to the anti- sense strand. The antisense and sense oligonucleotide comprise a single-stranded nucleic acid sequence (either RNA or DNA) capable of binding to target mRNA (sense) or DNA (antisense) sequences for lung cancer molecules. A preferred antisense molecule is for a lung cancer sequence in the tables, or for a ligand or activator thereof. Antisense or sense oligonucleotides, according to the present invention, comprise a fragment generally at least about 14 nucleotides, preferably from about 14 to 30 nucleotides. The ability to derive an antisense or a sense oligonucleotide, based upon a cDNA sequence encoding a given protein is described in, e.g., Stein and Cohen (1988) Cancer Res. 48:2659 and van der Krol, et al. (1988) BioTechniques 6:958).

RNA interference is a mechanism to suppress gene expression in a sequence specific manner. See, e.g., Bramelkamp, et al. (2002) Sciencexpress (21March2002); Shaφ (1999) Genes Dev. 13:139-141; and Cathew (2001) Curr. Op. Cell Biol. 13:244-248. In mammalian cells, short, e.g., 21 nt, double sfranded small interfering RNAs (siRNA) have been shown to be effective at inducing an RNAi response. See, e.g., Elbashir, et al. (2001) Nature 411 :494- 498. The mechanism may be used to downregulate expression levels of identified genes, e.g., treatment of or validation of relevance to disease.

Ribozymes

In addition to antisense polynucleotides, ribozymes can be used to target and inhibit transcription of lung cancer-associated nucleotide sequences. A ribozyme is an RNA molecule that catalytically cleaves other RNA molecules. Different kinds of ribozymes have been described, including group I ribozymes, hammerhead ribozymes, haiφin ribozymes, RNase P, and axhead ribozymes (see, e.g., Castanotto, et al. (1994) Adv. in Pharmacology 25: 289-317 for a general review ofthe properties of different ribozymes).

The general features of haiφin ribozymes are described, e.g., in Hampel, et al. (1990) Nucl. Acids Res. 18:299-304; European Patent Publication No. 0 360 257; U.S. Patent No. 5,254,678. Methods of preparing are well known to those of skill in the art (see, e.g., WO 94/26877; Ojwang, et al. (1993) Proc. Natl. Acad. Sci. USA 90:6340-6344; Yamada, et al. (1994) Human Gene Therapy 1:39-45; Leavitt, et al. (1995) Proc. Natl. Acad. Sci. USA 92:699-703; Leavitt, et al. (19994) Human Gene Therapy 5:1151-120; and Yamada, et al. (1994) Virology 205: 121-126). Polynucleotide modulators of lung cancer may be introduced into a cell containing the target nucleotide sequence by formation of a conjugate with a ligand binding molecule, as described in WO 91/04753. Suitable ligand binding molecules include, but are not limited to, cell surface receptors, growth factors, other cytokines, or other ligands that bind to cell surface receptors. Preferably, conjugation ofthe ligand binding molecule does not substantially interfere with the ability ofthe ligand binding molecule to bind to its corresponding molecule or receptor, or block entry ofthe sense or antisense oligonucleotide or its conjugated version into the cell. Alternatively, a polynucleotide modulator of lung cancer may be introduced into a cell containing the target nucleic acid sequence, e.g., by formation of an polynucleotide-lipid complex, as described in WO 90/10448. It is understood that the use of antisense molecules or knock out and knock in models may also be used in screening assays as discussed above, in addition to methods of freatment.

Thus, in one embodiment, methods of modulating lung cancer in cells or organisms are provided. In one embodiment, the methods comprise administering to a cell an anti-lung cancer antibody that reduces or eliminates the biological activity of an endogenous lung cancer protein. Alternatively, the methods comprise administering to a cell or organism a recombinant nucleic acid encoding a lung cancer protein. This may be accomplished in any number of ways. In a prefened embodiment, e.g., when the lung cancer sequence is down- regulated in lung cancer, such state may be reversed by increasing the amount of lung cancer gene product in the cell. This can be accomplished, e.g., by overexpressing the endogenous lung cancer gene or administering a gene encoding the lung cancer sequence, using known gene-therapy techniques. In a prefened embodiment, the gene therapy techniques include the incoφoration ofthe exogenous gene using enhanced homologous recombination (EHR), e.g., as described in PCT/US93/03868, hereby incoφorated by reference in its entirety.

Alternatively, e.g., when the lung cancer sequence is up-regulated in lung cancer, the activity ofthe endogenous lung cancer gene is decreased, e.g., by the administration of a lung cancer antisense or RNAi nucleic acid.

In one embodiment, the lung cancer proteins ofthe present invention may be used to generate polyclonal and monoclonal antibodies to lung cancer proteins. Similarly, the lung cancer proteins can be coupled, using standard technology, to affinity chromatography columns. These columns may then be used to purify lung cancer antibodies useful for production, diagnostic, or therapeutic puφoses. In a prefened embodiment, the antibodies are generated to epitopes unique to a lung cancer protein; that is, the antibodies show little or no cross-reactivity to other proteins. The lung cancer antibodies may be coupled to standard affinity chromatography columns and used to purify lung cancer proteins. The antibodies may also be used as blocking polypeptides, as outlined above, since they will specifically bind to the lung cancer protein.

Methods of identifying variant lung cancer-associated sequences

Without being bound by theory, expression of various lung cancer sequences is conelated with lung cancer. Accordingly, disorders based on mutant or variant lung cancer genes may be determined. In one embodiment, the invention provides methods for identifying cells containing variant lung cancer genes, e.g., determining all or part ofthe sequence of at least one endogenous lung cancer genes in a cell. In a prefened embodiment, the invention provides methods of identifying the lung cancer genotype of an individual, e.g., determining all or part ofthe sequence of at least one lung cancer gene ofthe individual. This is generally done in at least one tissue ofthe individual, and may include the evaluation of a number of tissues or different samples ofthe same tissue. The method may include comparing the sequence ofthe sequenced lung cancer gene to a known lung cancer gene, i.e., a wild-type gene.

The sequence of all or part ofthe lung cancer gene can then be compared to the sequence of a known lung cancer gene to determine if any differences exist. This can be done using known homology programs, such as Bestfit, etc. In a prefened embodiment, the presence of a difference in the sequence between the lung cancer gene ofthe patient and the known lung cancer gene conelates with a disease state or a propensity for a disease state, as outlined herein. In a prefened embodiment, the lung cancer genes are used as probes to determine the number of copies ofthe lung cancer gene in the genome.

In another prefened embodiment, the lung cancer genes are used as probes to determine the chromosomal localization ofthe lung cancer genes. Information such as chromosomal localization finds use in providing a diagnosis or prognosis in particular when chromosomal abnormalities such as translocations, and the like are identified in the lung cancer gene locus.

Administration of pharmaceutical and vaccine compositions

In one embodiment, a therapeutically effective dose of a lung cancer protein or modulator thereof, is administered to a patient. By "therapeutically effective dose" herein is meant a dose that produces effects for which it is administered. The exact dose will depend on the puφose ofthe treatment, and will be ascertainable by one skilled in the art using known techniques (e.g., Ansel, et al. (1992) Pharmaceutical Dosage Forms and Drug Delivery: Lieberman, Pharmaceutical Dosage Forms (vols. 1-3), Dekker, ISBN 0824770846, 082476918X, 0824712692, 0824716981; Lloyd (1999) The Art. Science and Technology of Pharmaceutical Compounding; and Pickar (1999) Dosage Calculations). Adjustments for lung cancer degradation, systemic versus localized delivery, and rate of new protease synthesis, as well as the age, body weight, general health, sex, diet, time of adminisfration, drug interaction and the severity ofthe condition may be necessary, and will be ascertainable with routine experimentation by those skilled in the art.

A "patient" for the puφoses ofthe present invention includes both humans and other animals, particularly mammals. Thus the methods are applicable to both human therapy and veterinary applications. In the prefened embodiment the patient is a mammal, preferably a primate, and in the most prefened embodiment the patient is human.

The adminisfration ofthe lung cancer proteins and modulators thereof of the present invention can be done in a variety of ways, including, but not limited to, orally, subcutaneously, intravenously, infranasally, transdermaUy, infraperitoneally, intramuscularly, mtrapulmonary, vaginally, rectally, or infraocularly. In some instances, e.g., in the treatment of wounds and inflammation, the lung cancer proteins and modulators may be directly applied as a solution or spray.

The pharmaceutical compositions ofthe present invention comprise a lung cancer protein in a form suitable for administration to a patient. In the prefened embodiment, the pharmaceutical compositions are in a water soluble form, such as being present as pharmaceutically acceptable salts, which is meant to include both acid and base addition salts. "Pharmaceutically acceptable acid addition salt" refers to those salts that retain the biological effectiveness ofthe free bases and that are not biologically or otherwise undesirable, formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like, and organic acids such as acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid and the like. "Pharmaceutically acceptable base addition salts" include those derived from inorganic bases such as sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts and the like. Particularly prefened are the ammonium, potassium, sodium, calcium, and magnesium salts. Salts derived from pharmaceutically acceptable organic non-toxic bases include salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine.

The pharmaceutical compositions may also include one or more ofthe following: carrier proteins such as serum albumin; buffers; fillers such as microcrystalline cellulose, lactose, corn and other starches; binding agents; sweeteners and other flavoring agents; coloring agents; and polyethylene glycol.

The pharmaceutical compositions can be administered in a variety of unit dosage forms depending upon the method of administration. For example, unit dosage forms suitable for oral administration include, but are not limited to, powder, tablets, pills, capsules and lozenges. It is recognized that lung cancer protein modulators (e.g., antibodies, antisense constructs, ribozymes, small organic molecules, etc.) when administered orally, should be protected from digestion. This is typically accomplished either by complexing the molecule(s) with a composition to render it resistant to acidic and enzymatic hydrolysis, or by packaging the molecule(s) in an appropriately resistant carrier, such as a liposome or a protection barrier. Means of protecting agents from digestion are well known in the art.

The compositions for administration will commonly comprise a lung cancer protein modulator dissolved in a pharmaceutically acceptable carrier, preferably an aqueous carrier. A variety of aqueous carriers can be used, e.g., buffered saline and the like. These solutions are sterile and generally free of undesirable matter. These compositions may be sterilized by conventional, well known sterilization techniques. The compositions may contain pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions such as pH adjusting and buffering agents, toxicity adjusting agents and the like, e.g., sodium acetate, sodium chloride, potassium chloride, calcium chloride, sodium lactate and the like. The concenfration of active agent in these formulations can vary widely, and will be selected primarily based on fluid volumes, viscosities, body weight and the like in accordance with the particular mode of administration selected and the patient's needs (e.g., Remington's Pharmaceutical Science (15th ed., 1980) and Hardman, et al. (eds. 1996) Goodman and Gilman: The Pharmacologial Basis of Therapeutics). Thus, a typical pharmaceutical composition for intravenous administration would be about 0.1 to 10 mg per patient per day. Dosages from 0.1 up to about 100 mg per patient per day may be used, particularly when the drag is administered to a secluded site and not into the blood stream, such as into a body cavity or into a lumen of an organ. Substantially higher dosages are possible in topical adminisfration. Actual methods for preparing parenterally administrable compositions will be known or apparent to those skilled in the art, e.g.,

Remington's Pharmaceutical Science and Goodman and Gilman, The Pharmacologial Basis of Therapeutics, supra. The compositions containing modulators of lung cancer proteins can be administered for therapeutic or prophylactic treatments. In therapeutic applications, compositions are administered to a patient suffering from a disease (e.g., a cancer) in an amount sufficient to cure or at least partially anest the disease and its complications. An amount adequate to accomplish this is defined as a "therapeutically effective dose." Amounts effective for this use will depend upon the severity ofthe disease and the general state ofthe patient's health. Single or multiple administrations ofthe compositions may be administered depending on the dosage and frequency as required and tolerated by the patient. In any event, the composition should provide a sufficient quantity ofthe agents of this invention to effectively freat the patient. An amount of modulator that is capable of preventing or slowing the development of cancer in a mammal is refened to as a "prophylactically effective dose." The particular dose required for a prophylactic treatment will depend upon the medical condition and history of the mammal, the particular cancer being prevented, as well as other factors such as age, weight, gender, administration route, efficiency, etc. Such prophylactic treatments may be used, e.g., in a mammal who has previously had cancer to prevent a recunence ofthe cancer, or in a mammal who is suspected of having a significant likelihood of developing cancer based, at least in part, upon gene expression profiles. Vaccine strategies may be used, in either a DNA vaccine form, or protein vaccine.

It will be appreciated that the present lung cancer protein-modulating compounds can be administered alone or in combination with additional lung cancer modulating compounds or with other therapeutic agent, e.g., other anti-cancer agents or treatments.

In numerous embodiments, one or more nucleic acids, e.g., polynucleotides comprising nucleic acid sequences set forth in the tables, such as antisense or RNAi polynucleotides or ribozymes, will be introduced into cells, in vitro or in vivo. The present invention provides methods, reagents, vectors, and cells useful for expression of lung cancer- associated polypeptides and nucleic acids using in vitro (cell-free), ex vivo, or in vivo (cell or organism-based) recombinant expression systems.

The particular procedure used to introduce the nucleic acids into a host cell for expression of a protein or nucleic acid is application specific. Many procedures for introducing foreign nucleotide sequences into host cells may be used. These include the use of calcium phosphate transfection, spheroplasts, electroporation, liposomes, microinjection, plasma vectors, viral vectors and other well known methods for introducing cloned genomic DNA, cDNA, synthetic DNA or other foreign genetic material into a host cell (see, e.g., Berger and Kimmel, Guide to Molecular Cloning Techniques. Methods in Enzymology volume 152 (Berger), Ausubel, et al. (eds. 1999) Cunent Protocols (supplemented through 1999), and Sambrook, et al. (1989) Molecular Cloning - A Laboratory Manual (2nd ed., Vol. 1-3). In a prefened embodiment, lung cancer proteins and modulators are administered as therapeutic agents, and can be formulated as outlined above. Similarly, lung cancer genes (including both the full-length sequence, partial sequences, or regulatory sequences ofthe lung cancer coding regions) can be administered in a gene therapy application. These lung cancer genes can include antisense or inhibitory applications, e.g., as inhibitory RNA or gene therapy (e.g., for incoφoration into the genome) or as antisense compositions.

Lung cancer polypeptides and polynucleotides can also be administered as vaccine compositions to stimulate HTL, CTL, and antibody responses.. Such vaccine compositions can include, e.g., lipidated peptides (see, e.g.,Vitiello, et al. (1995) J. Clin. Invest. 95:341), peptide compositions encapsulated in poly(DL-lactide-co-glycolide) ("PLG") microspheres (see, e.g., Eldridge, et al. (1991) Molec. Immunol. 28:287-294; Alonso, et al. (1994) Vaccine 12:299-306; Jones, et al. (1995) Vaccine 13:675-681), peptide compositions contained in immune stimulating complexes (ISCOMS) (see, e.g., Takahashi, et al. (1990) Nature 344:873-875; Hu, et al. (1998) Clin Exp Immunol. 113:235-243), multiple antigen peptide systems (MAPs) (see, e.g., Tarn (1988) Proc. Natl. Acad. Sci. U.S.A. 85:5409-5413; Tarn (1996) J. Immunol. Methods 196:17-32), peptides formulated as multivalent peptides; peptides for use in ballistic delivery systems, typically crystallized peptides, viral delivery vectors (Perkus, et al., p. 379 In: Kaufmann (ed. 1996) Concepts in vaccine development; Chakrabarti, et al. (1986) Nature 320:535; Hu, et al. (1986) Nature 320:537; Kieny, et al. (1986) AIDS Bio/Technology 4:790; Top, et al. (1971) J. Infect. Pis. 124:148; Chanda, et al. (1990) Virology 175:535), particles of viral or synthetic origin (see, e.g., Kofler, et al. (1996) J. Immunol. Methods 192:25; Eldridge, et al. (1993) Sem. Hematol. 30:16; Falo, et al. (1995) Nature Med. 7:649), adjuvants (Wanen, et al. (1986) Annu. Rev. Immunol. 4:369; Gupta, et al. (1993) Vaccine 11:293). liposomes (Reddy, et al. (1992) J. Immunol. 148:1585; Rock (1996) Immunol. Today 17:131), or, naked or particle absorbed cDNA (Ulmer, et al. (1993) Science 259:1745; Robinson, et al. (1993) Vaccine 11:957; Shiver, et al., p. 423 In:

Kaufmann (ed. 1996) Concepts in vaccine development: Cease and Berzofsky (1994) Annu. Rev. Immunol. 12:923 and Eldridge, et al. (1993) Sem. Hematol. 30:16). Toxin-targeted delivery technologies, also known as receptor mediated targeting, such as those of Avant Immunotherapeutics, Inc. (Needham, Massachusetts) may also be used.

Vaccine compositions often include adjuvants. Many adjuvants contain a substance designed to protect the antigen from rapid catabolism, such as aluminum hydroxide or mineral oil, and a stimulator of immune responses, such as lipid A, Bortadella pertussis or Mycobacterium tuberculosis derived proteins. Certain adjuvants are commercially available as, e.g., Freund's Incomplete Adjuvant and Complete Adjuvant (Difco Laboratories, Detroit, MI); Merck Adjuvant 65 (Merck and Company, Inc., Rahway, NJ); AS-2 (SmithKline Beecham, Philadelphia, PA); aluminum salts such as aluminum hydroxide gel (alum) or aluminum phosphate; salts of calcium, iron or zinc; an insoluble suspension of acylated tyrosine; acylated sugars; cationically or anionically derivatized polysaccharides; polyphosphazenes; biodegradable microspheres; monophosphoryl lipid A and quil A. Cytokines, such as GM-CSF, interleukin-2, -7, -12, and other like growth factors, may also be used as adjuvants. Vaccines can be administered as nucleic acid compositions wherein DNA or RNA encoding one or more ofthe polypeptides, or a fragment thereof, is administered to a patient. This approach is described, for instance, in Wolff, et. al. (1990) Science 247:1465 as well as U.S. Patent Nos. 5,580,859; 5,589,466; 5,804,566; 5,739,118; 5,736,524; 5,679,647; WO 98/04720; and in more detail below. Examples of DNA-based delivery technologies include "naked DNA", facilitated (bupivicaine, polymers, peptide-mediated) delivery, cationic lipid complexes, and particle-mediated ("gene gun") or pressure-mediated delivery (see, e.g., U.S. Patent No. 5,922,687).

For therapeutic or prophylactic immunization pmposes, the peptides ofthe invention can be expressed by viral or bacterial vectors. Examples of expression vectors include attenuated viral hosts, such as vaccinia or fowlpox. This approach involves the use of vaccinia virus, e.g., as a vector to express nucleotide sequences that encode lung cancer polypeptides or polypeptide fragments. Upon introduction into a host, the recombinant vaccinia virus expresses the immunogenic peptide, and thereby elicits an immune response. Vaccinia vectors and methods useful in immunization protocols are described in, e.g., U.S. Patent No. 4,722,848. Another vector is BCG (Bacille Cahnette Guerin). BCG vectors are described in Stover, et al. (1991) Nature 351:456-460. A wide variety of other vectors useful for therapeutic administration or immunization e.g., adeno and adeno-associated virus vectors, retroviral vectors, Salmonella typhi vectors, detoxified anthrax toxin vectors, and the like, will be apparent to those skilled in the art from the description herein (see, e.g., Shata, et al. (2000) Mol Med Today 6:66-71; Shedlock, et al. (2000) J. Leukoc. Biol. 68:793-806; Hipp, et al. (2000) In Vivo 14:571-85).

Methods for the use of genes as DNA vaccines are well known, and include placing a lung cancer gene or portion of a lung cancer gene under the control of a regulatable promoter or a tissue-specific promoter for expression in a lung cancer patient. The lung cancer gene used for DNA vaccines can encode full-length lung cancer proteins, but more preferably encodes portions ofthe lung cancer proteins including peptides derived from the lung cancer protein. In one embodiment, a patient is immunized with a DNA vaccine comprising a plurality of nucleotide sequences derived from a lung cancer gene. For example, lung cancer- associated genes or sequence encoding subfragments of a lung cancer protein are introduced into expression vectors and tested for their immunogenicity in the context of Class I MHC and an ability to generate cytotoxic T cell responses. This procedure provides for production of cytotoxic T cell responses against cells which present antigen, including intracellular epitopes.

In a prefened embodiment, DNA vaccines include a gene encoding an adjuvant molecule with the DNA vaccine. Such adjuvant molecules include cytokines that increase the immunogenic response to the lung cancer polypeptide encoded by the DNA vaccine. Additional or alternative adjuvants are available. In another prefened embodiment lung cancer genes find use in generating animal models of lung cancer. When the lung cancer gene identified is repressed or diminished in metastatic tissue, gene therapy technology, e.g., wherein antisense or inhibitory RNA directed to the lung cancer gene will also diminish or repress expression ofthe gene. Animal models of lung cancer find use in screening for modulators of a lung cancer-associated sequence or modulators of lung cancer. Similarly, transgenic animal technology including gene knockout technology, e.g., as a result of homologous recombination with an appropriate gene targeting vector, will result in the absence or increased expression ofthe lung cancer protein. When desired, tissue-specific expression or knockout ofthe lung cancer protein may be necessary. It is also possible that the lung cancer protein is overexpressed in lung cancer. As such, transgenic animals can be generated that overexpress the lung cancer protein.

Depending on the desired expression level, promoters of various strengths can be employed to express the transgene. Also, the number of copies ofthe integrated fransgene can be determined and compared for a determination ofthe expression level ofthe fransgene. Animals generated by such methods will find use as animal models of lung cancer and are additionally useful in screening for modulators to freat lung cancer.

Kits for Use in Diagnostic and/or Prognostic Applications For use in diagnostic, research, and therapeutic applications suggested above, kits are also provided by the invention. In diagnostic and research applications such kits may include at least one ofthe following: assay reagents, buffers, lung cancer-specific nucleic acids or antibodies, hybridization probes and/or primers, antisense polynucleotides, ribozymes, RNAi, dominant negative lung cancer polypeptides or polynucleotides, small molecule inhibitors of lung cancer-associated sequences, etc. A therapeutic product may include sterile saline or another pharmaceutically acceptable emulsion and suspension base.

In addition, the kits may include instructional materials containing instructions (e.g., protocols) for the practice ofthe methods of this invention. While the instructional materials typically comprise written or printed materials they are not limited to such. A medium capable of storing such instructions and communicating them to an end user is contemplated by this invention. Such media include, but are not limited to electronic storage media (e.g., magnetic discs, tapes, cartridges, chips), optical media (e.g., CD ROM), and the like. Such media may include addresses to internet sites that provide such instructional materials. The present invention also provides for kits for screening for modulators of lung cancer-associated sequences. Such kits can be prepared from readily available materials and reagents. For example, such kits can comprise one or more ofthe following materials: a lung cancer-associated polypeptide or polynucleotide, reaction tubes, and instructions for testing lung cancer-associated activity. Optionally, the kit contains biologically active lung cancer protein. A wide variety of kits and components can be prepared according to the present invention, depending upon the intended user ofthe kit and the particular needs ofthe user. Diagnosis would typically involve evaluation of a plurality of genes or products. The genes typically will be selected based on conelations with important parameters in disease which may be identified in historical or outcome data. EXAMPLES

Example 1 : Gene Chip Analysis

Molecular profiles of various normal and cancerous tissues were determined and analyzed using gene chips. RNA was isolated and gene chip analysis was performed as described (Glynne, et al. (2000) Nature 403:672-676; Zhao, et al. (2000) Genes Dev. 14:981- 993).

Tables 1A and 1B were previously filed on April 18, 2001 in USSN 60/284,770 (18501-001500US) and on November 29, 2001 in USSN 60/334,370 (18501-001520US)

Table W

Pkey ExAccn UnigeπelD Unigene Title 70% chroπ/90% NL 70% SQAD/90% NL

100134 D13264 Hs 49 macrophage scavenger receptor 1 1 61 074

100780 HG3731-HT4001 """Immunoglobulin Heavy Cham, Vdjrc Reg 268 328

100971 J02874 Hs 83213 fatty acid binding protein 4, adipocyte 1 96 0 14

101088 L05568 Hs 553 solute earner family 6 (neurotransmitte 079 007

101102 L07594 Hs 79059 transforming growth factor, beta recepto 255 1

101168 L15388 Hs 211569 G protein coupled receptor kinase 5 088 027

101277 L38486 Hs 118223 microfibπllar associated protein 4 089 0 26

101330 L43821 Hs 80261 enhancer of filamentatioπ 1 (cas like do 059 029

101336 L49169 Hs 75678 FBJ murine osteosarcoma viral oncogene h 1 15 041

101345 L76380 Hs 152175 cablonin receptor like 081 031

101678 M62505 Hs 2161 complement component 5 receptor 1 (C5a I 1 31 077

101764 M80563 Hs 81256 S100 calcium binding protein A4 (calcium 1 44 082

101771 M81750 Hs 153837 myeloid cell nuclear differentiation ant 096 045

101842 M93221 Hs 75182 mannose receptor; C type 1 1 27 037

102283 U31384 Hs 83381 guanine nucleotide binding protein 11 1 04 03

102363 U39447 Hs 198241 amiπe oxidase, copper containing 3 (vase 096 026

102607 U52154 Hs 193044 potassium inwardly-rectifying channel, s 281 3 5

102698 U75272 Hs 1867 progastπcsin (pepsmogen C) 095 023

103025 X54131 Hs 123641 protein tyrosine phosphatase, receptor t 1 62 021

103280 X79981 Hs 76206 cadhenn 5, VE-cadhenn (vascular epithe 09 041

103496 Y09267 Hs 132821 flavin containing monooxygenase 2 1 27 049

103541 211697 , Hs 79197 CD83 antigen (activated B lymphocytes, i 1 86 1

103554 Z18951 Hs 74034 caveolin 1 , caveolae protein, 22kD 1 27 047

104212 AB002298 Hs 173035 KIAA0300 protein 1 17 0 16

104691 AA011176 Hs 37744 ESTs 1 08 0 35

104825 AA035613 Hs 141883 ESTs 075 027

104857 AA043219 Hs 19058 ESTs 26 33

104865 AA045136 Hs 22575 ESTs 1 23 049

104989 AA102098 Hs 118615 ESTs 063 032

105729 AA292694 Hs 3807 ESTs, Weakly similar to PHOSPHOLEMMAN PR 0 86 034

105847 AA398606 Hs 32241 ESTs 1 32 04

105894 AA400979 Hs 25691 calcitonin receptor-like receptor activi 078 028

106490 AA451861 Hs 115537 ESTs, Weakly similar to dipeptidase prec 1 2 047

106536 AA453997 Hs 23804 ESTs 0 82 0 15

106605 AA457718 Hs 21103 Homo sapiens mRNA cDNA DKFZp564B076 (fr 099 0 07

106667 AA461086 Hs 16578 ESTs 1 17 04

106773 AA478109 Hs 188833 ESTs 1 46 043

106797 AA478962 Hs 169943 ESTs 1 18 032

106844 AA485055 Hs 158213 sperm associated antigen 6 098 0 51

106870 AA487576 Hs 26530 serum deprivation response (phosphatidyl 1 05 014

106954 AA496980 Hs 204038 ESTs 1 25 033

107054 AA600150 Hs 14366 ESTs 1 11 04

107292 T30407 Hs 4789 ESTs, Weakly similar to oxidative-stress 1 07 258

107994 AA036811 Hs 165030 ESTs 07 021

107997 AA037388 Hs 82223 Human DNA sequence from clone 141H5 on c 1 02 048

108041 AA041552 Hs 61957 ESTs 1 44 051

108087 AA045709 Hs 40545 ESTs 1 98 1

108382 AA074885 Hs 67726 macrophage receptor with collageπous str 1 52 072

108435 AA078787 Hs 194101 ESTs 253 1 53

108480 AA081093 Hs 68055 ESTs 1 56 048

109252 AA194830 Hs 85944 ESTs 269 318

109550 F01534 Hs 26981 ESTs 1 19 065

109613 F03031 Hs 27519 ESTs 1 01 029

109837 H00656 Hs 29792 ESTs 081 0 15

109893 H04768 Hs 30484 ESTs 1 44 032

109984 H09594 Hs 10299 ESTs 062 014

110099 H16568 Hs 23748 ESTs 1 01 028

110837 N30796 Hs 17424 ESTs, Weakly similar to semaphoπn F [H 1 1 022

111247 N6S825 Hs 16762 Homo sapiens mRNA, cDNA DKFZp564B2062 (f 1 26 026

111341 N80935 Hs 22483 ESTs 1 57 0 52

111510 R07856 Hs 16355 ESTs 396 1

111737 R25410 Hs 9218 ESTs 097 024

113195 T57112 """yc20g11 s1 Stratagene lung (#937210) 1 22 035

113238 T62979 Hs 189813 ESTs 227 045

113540 T90496 Hs 16757 ESTs 1 06 022

113552 T90889 Hs 16026 ESTs 1 16 042

113606 T93093 Hs 17125 ESTs 1 48 07

113695 T96965 Hs 1 948 ESTs 1 54 0 28

113946 W84753 Hs 37896 ESTs 1 79 072

114251 Z39898 Hs 21948 ESTs 1 95 025

114359 Z41589 Hs 153483 ESTs, Moderately similar to H1 chloride 1 42 0 13

115230 AA278300 Hs 182980 ESTs 262 042

115279 AA279760 Hs 63671 ESTs 1 79 091

115566 AA398083 Hs 43977 ESTs 086 02

115965 AA446661 Hs 173233 ESTs 079 004

116166 AA461556 Hs 202949 KIAA1102 protein 229 068

116279 AA486073 Hs 57362 ESTs 227 078

117023 H88157 Hs 41105 ESTs 1 36 0 16 117209 H99959 Hs 42768 ESTs 1 46 048

118901 N90719 Hs 94445 ESTs 1 51 1

118981 N93839 Hs 39288 ESTs 1 34 048

119073 R32894 Hs 45514 v-ets avian erythroblastosis virus E26 o 1 14 027

119221 R98105 ™"yr30g11 s1 Soares fetal liver spleen 1 32 053

119824 W74536 Hs 184 advanced glycosylation end product-speci 1 0 19

119861 W80715 ESTs, Moderately similar to «" ALU SUB 1 83 045

120041 W92775 Hs 59368 ESTs 1 23 055

120132 Z38839 Hs 125019 ESTs, Highly similar to KIAA0886 protein 091 037

120467 AA251579 Hs 187628 ESTs 1 87 1 91

121314 AA402799 Hs 182538 ESTs 1 3 031

121643 AA417078 Hs 193767 ESTs 231 068

121690 AA418074 Hs 110286 ESTs 1 47 051

122633 AA454080 Hs 34853 inhibitor of DNA binding 4, dominant neg 1 31 063

123978 C20653 Hs 170278 ESTs 1 52 032

124214 H58608 Hs 151323 ESTs 093 035

124357 N22401 """yw37g07 s1 Morton Fetal Cochlea Homo 1 29 1

124438 N40188 Hs 102550 ESTs 1 36 07

125167 W45560 Hs 102541 ESTs 1 46 069

125174 W51835 Hs 231082 EST 307 376

125422 AA903229 Hs 153717 ESTs 1 34 03

125561 AI417667 Hs 22978 ESTs 1 89 063

125831 D60988 "'"HUM145B09B Clontech human fetal brain 094 036

127002 R35380 Hs 24979 ESTs 302 406

127307 AA369367 Hs 126712 ESTs, Weakly similar to plL2 hypothetica 1 01 069

127609 AA622559 Hs 150318 ESTs 1 21 032

127959 AI302471 Hs 124292 ESTs 25 1

128458 D52193 Hs 56340 ESTs 1 13 033

128624 AA479209 Hs 102647 ESTs 1 45 058

128789 AA486567 Hs 105695 ESTs 1 1 034

128798 AF014958 Hs 105938 chemokine (C-C motif) receptor-like 2 1 16 055

128952 R51076 Hs 107361 ESTs, Highly similar to Rap2 interacting 204 24

129057 X62466 Hs 214742 CDW52 antigen (CAMPATH-1 antigen) 1 77 073

129210 AA401654 Hs 202949 KIAA1102 protein 1 11 036

129240 W24360 Hs 237868 interleukin 7 receptor 091 041

129402 T63781 "^π"yc21g01 s1 Stratagene lung (#937210) 1 36 043

129565 X77777 Hs 198726 vasoactive intestinal peptide receptor 1 067 008

129593 AA487015 Hs 98314 Homo sapiens mRNA, cDNA DKFZp586L0120 (f 1 3 042

129626 AA447410 Hs 11712 ESTs, Weakly similar to «« ALU SUBFAMI 1 28 046

129699 AA458578 Hs 12017 KIAA0439 protein, homolog of yeast ubiqu 1 58 1

129898 N48595 Hs 13256 ESTs 1 13 053

129958 L20591 Hs 1378 annexm A3 081 031

130273 U59914 Hs 153863 MAD (mothers against decapentaplegic, Dr 059 022

130655 N92934 Hs 17409 cysteine rich protein 1 (intestinal) 1 44 076

130657 T94452 Hs 201591 ESTs 096 042

131061 N64328 Hs 22567 ESTs, Moderately similar to HYPOTHETICAL 1 51 045

131066 F09006 Hs 22588 ESTs 097 037

131263 R38334 Hs 24950 regulator of G protein signalling 5 234 282

131589 U52100 Hs 29191 epithelial membrane protein 2 1 2 062

131686 AA157428 Hs 30687 Grb2-assocιated binder 2 095 038

131751 H18335 Hs 31562 ESTs 1 47 052

132430 T23630 Hs 258675 EST 1 86 209

132476 N67192 Hs 49476 Homo sapiens clone TUA8 Cπ-du-chat regi 1 73 058

132836 F09557 Hs 57929 slit (Drosophila) homolog 3 091 029

133120 X64559 Hs 65424 tetranectin (plasminogen binding protein 082 02

133488 D45370 Hs 74120 adipose specific 2 1 29 048

133565 H57056 Hs 204831 ESTs 225 057

133651 U97105 Hs 173381 dihydropyπmidinase like 2 1 65 062

133835 AA059489 Hs 76640 ESTs, Highly similar to RGC-32 [R norveg 1 16 0 34

133978 W73859 Hs 78061 transcription factor 21 079 027

133985 L34657 Hs 78146 platelet/eπdothelial cell adhesion molec 099 028

134299 AA487558 Hs 8135 ESTs 1 02 046

134300 U81984 Hs 166082 endothelial PAS domain protein 1 086 042

134323 AA028976 Hs 8175 Homo sapiens mRNA cDNA DKFZp564M0763 (f 1 19 027

134343 D50683 Hs 82028 transforming growth factor, beta recepto 1 21 0 67

134417 D87969 Hs 82921 solute earner family 35 (CMP-sialic aci 1 28 1

134561 U76421 Hs 85302 adenos e deamiπase, RNA-specific, Bl (h 2 12 055

134624 W67147 Hs 8700 deleted in liver cancer 1 235 274

134696 H88354 Hs 8861 ESTs 1 35 033

134749 L10955 Hs 89485 carbonic anhydrase IV 089 02

134786 L06139 Hs 89640 TEK tyrosine kinase, endothelial (venous 048 0 21

134869 T35288 Hs 90421 ESTs, Moderately similar to "" ALU SUB 214 264

135346 M21056 Hs 992 phospholipase A2, group IB (pancreas) 063 013

100113 D00591 Hs 84746 Chromosome condensation 1 1 2 15

100147 D13666 Hs 136348 Homo sapiens mRNA for osteoblast specifi 05 2

100280 D42085 Hs 155314 KIAA0095 gene product 1 02 1 39

100335 D63391 Hs 6793 platelet-activating factor acetylhydrola 1 558

100360 D78335 Hs 75939 Undine monophosphate kinase 091 204

100372 D79997 Hs 184339 KIAA0175 gene product 075 203

100486 HG1112-HT1112 TIGR ras-like protein TC4 1 09 1 93

100559 HG2197-HT2267 "collagen, type VII, alpha 1" 097 36

100576 HG2290-HT2386 "calcitonm/alpha CGRP, alt transcπpt 1 1

100668 HG2981-HT3938 "TIGR CD44 (epican, alt transcript 12 085 1 9

100906 HG4716-HT5158 Guanosine 5'-Monophosphate Synthase 1 18 229

100930 HG721-HT4827 "TIGR placental protein 14, endometrial 1 1 45 100960 J00124 Hs.117729 keratin 14 (epidermolysis bullosa simple 0.84 2.6

101031 J05070 Hs.151738 "Matrix metalloproteinase 9 (gelatinase 0.77 1.52

101111 L08424 Hs.1619 Achaete-scute complex (Drosophila) homol 1 1

101124 L10343 Hs.112341 "Protease inhibitor 3, skin-derived (SKA 0.62 2.67

101175 L18920 Hs.36980 "Melanoma antigen, family A, 2" 1 1

101204 L24203 Hs.82237 Ataxia-telangiectasia group D-associated 0.74 4.1

101431 M19888 Hs.1076 Small proliπe-rich protein IB (cornifiπ) 0.85 2.51

101448 M21389 Hs.195850 keratin 5 (epidermolysis bullosa simplex . 0.61 8.83

101511 M27826 Hs.267319 Endogenous retroviral protease 1.03 1.13

101526 M29540 Hs.220529 Carcinoembryonic antigen-related cell ad 1.07 4.61

101548 M31328 Hs.71642 "Guanine nucleotide binding protein (G p 0.97 1.13

101625 M57293 "Human parathyroid hormone-related pepti 1 1

101649 M60047 Hs.1690 Heparin-binding growth factor binding pr 1 2.7

101724 M69225 Hs.620 bullous pemphigoid antigen 1 (230/240kD) 1 8.98

101748 M76482 Hs.1925 Desmoglein 3 (pemphigus vulgaris antigen 1 2.78

101759 M80244 Hs.184601 "Solute carrier family 7 (cationic amino 1.07 2.45

101804 M86699 Hs.169840 TTK protein kinase 1 1

101806 M86757 Hs.112408 S100 calcium-binding protein A7 (psorias 0.74 1.76

101809 M86849 "Homo sapiens connexin 26 (GJB2) mRNA, c 1 7

101845 M93426 Hs.78867 "Protein tyrosine phosphatase, receptor- 1 1

101851 M94250 Hs.82045 Midkine (neurite growth-promoting factor 1.13 2.6

102083 U10323 Hs.75117 "Interleukin enhancer binding factor 2, 1.03 1.61

102154 U17760 Hs.75517 "Laminin, beta 3 (nicein (125kD), kalini 0.94 3.62

102193 U20758 Hs.313 secreted phosphoprotein 1 (osteopontin; 0.34 4.59

102305 U33286 Hs.90073 chromosome segregation 1 (yeast homolog) 1.45 2.97

102348 U37519 Hs.87539 Aldehyde dehydrogenase 8 0.52 2.25

102581 U61145 Hs.77256 Enhancer of zeste (Drosophila) homolog 2 0.91 2.46

102610 U65011 Hs.30743 Preferentially expressed antigen in mela 1 3.88

102623 U66083 Hs.37110 "Melanoma antigen, family A, 9 (MAGE-9)" 1 1

102669 U71207 Hs.29279 Eyes absent (Drosophila) homolog 2 1 1

102696 U74612 Hs.239 Forkhead box M1 1.06 2.77

102829 U91618 Hs.80962 Neurotensin 1 1

102888 X04741 Hs.76118 Ubiquitin carboxyl-terminal esterase L1 1.13 2.59

102913 X07696 Hs.80342 keratin 15 0.7 4.72

102915 X07820 Hs.2258 Matrix Metalloproteinase 10 (Stromolysin 1.15 3.35

102963 X15943 Hs.37058 "Calcitonin/calcitonin-related polypepti 1 1

103021 X53587 Hs.85266 "Integrin, beta 4" 1.38 2.34

103036 X54925 Hs.83169 Matrix metalloprotease 1 (interstitial c 1 14.93

103058 X57348 Hs.184510 Stratifin 1.25 4.17

103060 X57766 Hs.155324 matrix metalloproteinase 11 (stromelysin 1 1.72

103119 X63629 Hs.2877 "Cadherin 3, P-cadherin (placental)" 1.16 7.38

103206 X72755 Hs.77367 monokin^'e induced by gamma interferon 0.71 1.48

103242 X76342 Hs.389 "Alcohol dehydrogenase 7 (class IV), mu 1 1

103312 X82693 Hs.3185 "Lymphocyte antigen 6 complex, locus D; 0.92 1.28

103478 Y07755 Hs.38991 S100 calcium-binding protein A2 1.05 5.81

103558 Z19574 Hs.2785 keratin 17 0.65 6.68

103576 Z26317 Hs.2631 Desmoglein 2 0.79 1.73

103587 Z29083 , Hs.82128 5T4 Oπcofetal antigen 1 3.93

103594 Z31560 Hs.816 "SRY (sex determining region Y)-box 2, p 0.71 7.23

103768 AA089997 "ESTs, Highly similar to integral membra 0.99 1.8

104158 AA454908 Hs.8127 KIAA0144 gene product 0.96 1.29

104558 R56678 Hs.88959 Human DNA sequence from clone 967N21 on 1.23 7.23

104689 AA010665 ESTs 0.96 2.11

104733 AA019498 Hs.23071 ESTs 1.18 1.88

104906 AA055809 Hs.26802 Protein kinase domains containing protei 1.11 3.15

104978 AA088458 Hs.19322 ESTs; Weakly similar to III! ALU SUBFAMI 1.64 2.89

105012 AA116036 Hs.9329 "Homo sapiens mRNA for fls353, complete 1.19 3.91

105175 AA186804 Hs.25740 ESTs; Weakly similar to unknown [S.cerev 0.9 4.63

105263 AA227926 Hs.6682 ESTs 0.95 2.87

105298 AA233459 Hs.26369 ESTs 1 1.13

105312 AA233854 Hs.23348 S-phase kinase-associated protein 2 (p45 1.32 3.01

105719 AA291644 Hs.36793 Hypothetical protein FLJ23188 1.28 2.31

105743 AA293300 Hs.9598 ESTs 1 1

106012 • AA411621 Hs.8895 ESTs; same as BFH6? 0.94 2.04

106231 AA429571 Hs.38002 KIAA1355 protein 1.04 1.5

106540 AA454607 Hs.38114 Hypothetical protein FLJ11100 1.26 2.26

106575 AA456039 Hs.105421 ESTs 1 2

106632 AA459897 Hs.11950 GPI-anchored metastasis-associated prate 0.87 1.32

106727 AA465342 Hs.34045 Hypothetical protein FLJ20764 0.87 1.59

106906 AA490237 Hs.222024 Transcription factor BMAL2 (cycle-like f 0.61 1.6

107059 AA608545 Hs.23044 RAD51 (S. cerevisiae) homolog (E coli Re 0.48 2.67

107104 AA609786 Hs.15243 Nucleolar protein 1 (120kD) 1.01 1.44

107151 AA621169 Hs.8687 ESTs; procollagen l-N proteinase 0.97 2.89

107284 S74039 Hs.291904 Accessory proteins BAP31/BAP29 1.15 3.65

107901 AA026418 Hs.91539 ESTs 0.72 3.44

107922 AA028028 Hs.61460 Ig superfamily receptor LNIR precursor 1 2.48

107932 AA029317 Hs.18878 Hypothetical protein FLJ21620 1 1

108695 AA121315 Hs.70823 KIAA1077 protein 0.91 3.53

108857 AA133250 Hs.62180 ESTs 1 1

108860 AA133334 Hs.129911 ESTs 0.73 7.3

108990 AA152296 Hs.72045 ESTs 1 1

109166 AA179845 Hs.73625 "RAB6 interacting, kinesin-like (rabkiπe 1 4.55

109424 AA227919 Hs.85962 Hyaluronan synthase 3 1 1.28

109665 F05012 Hs.27027 Hypothetical protein DKFZp762H1311 1.42 2

109970 H09281 Hs.13234 ESTs 1.13 2.16 110015 H10998 Hs.7164 Adisintegrin and metalloproteinase doma 0.84 1.95

110156 H18957 Hs.4213 ESTs 0.94 1.41

110561 H59617 Hs.5199 HSPC150 protein similar to ubiquitin-con 0.91 3.18

111223 N68921 Hs.34806 ESTs; Weakly similar to neogenin [H.sapi 0.91 3.13

111345 N89820 Hs.14559 Hypothetical protein FLJ 10540 1 1.25

111876 R38239 Hs.293246 "ESTs, Weakly similar to putative p150 [ 0.83 1.27

111902 R39191 Hs.109445 KIAA1020 protein 0.91 0.91

112244 R51309 Hs.70823 KIAA1077 protein 0.77 3.01

112973 T17271 "cDNA FLJ13308 fis, clone OVARC1001436, 1 1

112989 T23482 Hs.89981 "Diacylglycerol kinase, zeta (104kD)" 0.55 1.03

113047 T25867 Hs.7549 ESTs 0.87 2

113095 T40920 Hs.126733 ESTs 1 1

113531 T90345 Hs.16740 Hypothetical protein FLJ 11036 0.42 1.44

113970 W86748 Hs.8109 ESTs 1.17 1.73

114346 Z41450 Hs.130489 "ATPase, aminophospholipid transporter-l 0.86 0.82

114407 AA010188 Hs.103305 ESTs 0.8 1.88

114471 AA028074 Hs.104613 RP42 homolog 1.06 1.34

114509 AA043551 Hs.101799 KIAA1350 protein 1.82 2.32

115060 AA253214 Hs.198249 "Gap junction protein, beta 5 (connexin 0.79 1.49

115091 AA255900 Hs.184523 KIAA0965 protein 0.72 1.92

115123 AA256642 Hs.236894 "ESTs, High sim to LRP1 hu low density I 0.59 1.97

115291 AA279943 Hs.122579 ESTs 1 1.25

115506 AA292537 Hs.45207 Hypothetical protein KIAA1335 1.15 1.48

115522 AA331393 Hs.47378 ESTs 0.5 3.29

115536 AA347193 Hs.62180 ESTs 1 1

115697 AA411502 Hs.63325 Homo sapiens type II membrane serine pro 1 6.53

115909 AA436666 Hs.59761 ESTs 1 6.98

115978 AA447522 Hs.6951 Differentially expressed in Fanconi anem 1 2.31

116028 AA452112 Hs.42644 thioredoxin-like 0.99 1.68

116107 AA456968 Hs.92030 ESTs 1.14 1.8

116134 AA460246 Hs.50441 CGI-04 protein 1.11 1.86

116157 AA461063 Hs.44298 Hypothetical protein 0.99 1.9

116158 AA461187 Hs.61762 Hypoxia-inducible protein 2 0.44 0.86

116335 AA495830 Hs.87013 "Homo sapiens cDNA FLJ10238 fis, clone H 0.62 3.89

116483 C14092 Hs.76118 Ubiquitin carboxyl-terminal esterase L1 1.04 2.36

117320 N23239 Hs.211092 LUNX protein; PLUNC(palate lung & nasal 0.51 0.64

117557 N33920 Hs.44532 Diubiquitin 1.11 2.63

117693 N40939 Hs.112110 PTD007 protein 0.98 1.79

117881 N50073 Hs.260622 Butyrate-induced transcript 1 1 1.43

118368 N64339 Hs.48956 ESTs 0.67 2.86

118566 N68558 Hs.42824 Hypothetical protein FLJ10718 1.21 0.83

118695 N71781 Hs.50081 KIAA1199 see CVA7.doc 0.88 1.63

119780 W72967 Hs.191381 ESTs; Weakly similar to hypothetical pro 1 1

119845 W79920 Hs.58561 G protein-coupled receptor 87 1 1

120102 W95428 Hs.132927 "ESTs, Moderately similar to p53 regulat 1 1

120104 W95477 Hs.180479 ESTs 0.69 3.07

120486 AA253400 Hs.137569 Tumor protein 63 kDa with strong homolog 1.08 12.05

120859 AA350158 Hs.1619 Achaete-scute complex (Drosophila) homol 1 1

120880 AA360240 Hs.97019 EST 1 1

120948 AA397822 Hs.104650 Hypothetical protein FLJ10292 1.04 2.15

120983 AA398209 Hs.97587 EST 1 1

121362 AA405500 Hs.97932 Chondromodulin I precursor 1 1

121369 AA405657 Hs.128791 CGI-09 protein 1 1.8

121791 AA423978 Hs.293317 "ESTs, Weakly similar to JM27 (H.sapiens 1 1

123005 AA479726 Hs.105577 ESTs 1 1

123044 AA481549 Hs.130881 B-cell CLL/lymphoma 11 A (zinc finger pro 0.95 1.88

123160 AA488687 Hs.284235 ESTs 1.59 4.98

123479 AA599469 Hs.135056 clone RP5-850E9 on chromosome 20 1.19 1.64

123571 AA608956 Hs.112619 "ESTs, Weakly similar to PQ0109 Purkiπje 1.03 1.14

123829 AA620697 Hs.112208 XAGE-1 protein 1.39 2.2

124006 D60302 Hs.108977 ESTs 1 4.85

124059 F13673 Hs.99769 ESTs 1.49 8.62

124960 T15386 Hs.194766 Seizure related gene 6 (mouse)-like 0.76 0.77

125218 W73561 Hs.110024 NADH:ubiquinone oxidoreductase MLRQ subu 1.33 1.77

125453 R06041 Hs.18048 "Melanoma antigen, family A, 10" 0.8 1.42

125759 AA425587 Hs.82226 Glycoprotein (transmembrane) nmb 1.52 2.26

125972 AA434562 Hs.35406 "ESTs, Highly similar to unnamed protein 1.05 2.48

125994 H55782 Hs.270799 EST 1 1.95

126395 N70.192 Hs.278956 Hypothetical protein FLJ12929 . 1 1.35

126645 AI167942 Hs.61635 STEAP1 (Homo sapiens BAC clone RG041 D11 1 2.23

127221 AI354332 Hs.72365 ESTs 0.73 3.27

127479 AA513722 Hs.179729 collagen; type X; alpha 1 (Schmid metaph 0.51 1.94

128192 AI204246 KIAA1085 protein 1.8 3.16

128610 L38608 Hs.10247 activated leucocyte cell adhesion molecu 0.89 0.97

128777 U46006 Hs.10526 Cysteine and glycine-rich protein 2 1 1

128924 AA234962 Hs.26557 Plakophilin 3 1.3 2.97

129041 H58873 Hs.169902 "Solute carrier family 2 (facilitated gl 0.84 2.04

129099 H50398 Hs.108660 "ATP-binding cassette, sub-family C (CFT 0.87 1.04

129404 AA172056 Hs.111128 ESTs 1 1

129466 L42583 "Genbank Homo sapiens keratin 6 isoform 0.72 12.67

129605 S72493 Hs.115947 Keratin 16 (focal noπ-epidermolytic palm 0.92 1.5

129628 U26727 Hs.1174 "Cyclin-dependent kinase inhibitor 2A (m 0.85 1.93

130023 X13461 Hs.239600 Calmodulin-like 3 0.84 1.22

130080 X14850 Hs.147097 "H2A histone family, member X" 0.98 1.96

130385 AA126474 Hs.155223 stanniocalcin 2 1 1 130410 V01514 Hs 155421 Alpha fetoprotein 063 063

130441 U35835 Hs 301387 "Human DNA PK mRNA, partial eds" 1 15 365

130482 L32866 Hs 1578 Baculoviral IAP repeat-containing 5 (sur 1 1 88

130553 AA430032 Hs 252587 Pituitary tumor transforming 1 092 1 96

130577 M35410 Hs 162 Insulin like growth factor binding prate 1 17 47

130627 L23808 Hs 1695 Matπx metalloproteinase 12 (macrophage 069 405

130800 AA223386 Hs 19574 ESTs Weakly similar to katanin p80 subu 1 13 241

130939 AA598689 Hs 21400 ESTs 08 089

131046 X02530 Hs 2248 INTERFERON-GAMMA INDUCED PROTEIN PRECURS 08 1 15

131244 D38076 Hs 24763 RAN binding protein 1 1 13 1 85

131877 J04088 Hs 156346 Topoisomerase (DNA) II alpha (170kD) 1 1

131927 AA461549 Hs 34780 "Doublecortex, lissencephaly, X linked ( 081 062

131965 W90146 Hs 35962 ESTs 074 327

131978 D80008 Hs 36232 KIAA0186 gene product 1 1

132354 L05187 Hs 211913 Small proline πch protein 1A 069 1 43

132543 AA417152 Hs 5101 ESTs, Highly similar to protein regulati 079 427

132632 N59764 Hs 5398 guanine monophosphate synthetase 1 1 08

132653 U31201 Hs 54451 "laminin gamma2 chain gene (LAMC2), exon 1 1

132659 Z75190 Hs 54481 "Low density lipoprotein receptor relate 089 089

132710 W93726 Hs 55279 'Senne (orcysteme) proteinase inhibit 0 64 441

132758 W52432 Hs 56105 "ESTs Weakly similar to WDNM RAT WDNM1 1 55 208

132767 L05188 Hs 231622 Small proline rich protein 2B 083 1 66

132816 M74542 Hs 575 Aldehyde dehydrogenase 3 0 55 055

132990 AA458761 Hs 18387 transcription factor AP-2 alpha (activat 1 353

133070 U69611 Hs 64311 "A disintegπn and metalloproteinase dom 1 16 2

133282 U52960 Hs 286145 "SRB7 (suppressor of RNA polymerase B y 1 27

133317 AA215299 Hs 70830 U6 snRNA associated Sm like protein LSm7 095 1 42

133370 AA156897 Hs 72157 Homo sapiens mRNA cDNA DKFZp564H922 1 12 255

133391 X57579 Hs 727 H sapiens activin beta A subunit (exon 2 1 65 1 76

133832 H03387 Hs 241305 estrogen responsive B box protein (EBBP) 1 02 1 39

134032 Z81326 Hs 78589 "Senne (orcysteme) proteinase inhibit 1

134168 AA398908 Hs 181634 "Homo sapiens cDNA FLJ23602 fis, clone 095 1 53

134218 AA227480 Hs 80205 Pιm-2 oncogene 1 36 248

134405 R67275 Hs 82772 """collagen, type XI, alpha 1""" 076 286

134453 X70683 Hs 83484 SRY (sex determining region Y) box 4 1 89 378

134470 X54942 Hs 83758 CDC28 protein kinase 2 1 82 411

134645 U87459 Hs 167379 "Cancer/testis antigen (NY-ESO-1, CTAG1, 082 083

134781 M17183 Hs 89626 Parathyroid hormone like hormone 1 1

135002 U19147 Hs 272484 G antigen 6 1 1

100040 M97935 AFFX control STAT1 0 92 1 25

101201 L22524 Hs 2256 matrix metalloproteinase 7 (matπlysin, 292 85

101664 M60752 Hs 121017 H2A histoπe family, member A 1 1

102025 U03911 Hs 78934 mutS (E coli) homolog 2 (colon cancer, 08 1 61

102031 U04898 Hs 2156 RAR related orphan receptor A 1 1

102221 U24576 LIM domain only 4 1 1

102270 U30255 Hs 75888 phosphogluconate dehydrogenase 1 08 1 3

102339 U37022 Hs 95577 cyclin dependent kinase 4 0 88 1 32

102391 U41668 Hs 77494 deoxyguanosine kinase 1 07 1 58

103000 X51956 Hs 146580 enolase 2, (gamma neuronal) 091 1 49

103395 X94754 Hs 119503 methionine tRNA synthetase 089 1 32

105638 AA281599 Hs 20418 Homo sapiens mRNA for for histone H2B, c 091 1 25

105726 AA292328 Hs 9754 activating transcription factor 5 0 94 1 8

114841 AA234722 Hs 55408 ESTs Moderately similar to CALCIUM DEPE 078 1 56

115206 AA262491 Hs 186572 ESTs 1 1

115906 AA436616 Hs 82302 ESTs 074 252

119132 R49046 Hs 107911 ATP binding cassette, sub family B (MDR/ 1 1 1 51

124163 H30539 Hs 189838 ESTs 1 1

126487 AA482505 Hs 184601 solute carrier family 7 (cationic ammo 1 01 1 46

127141 AA307960 Hs 75478 KIAA0956 protein 085 1 4

128034 AA905754 Hs 75103 tyrosine 3-monooxygenase/tryptophan 5-mo 1 1 18

128609 AA234365 Hs 102456 survival of motor neuron protein interac 1 1 5

128895 R37753 Hs 106985 ESTs 1 7 2

130199 Z48579 Hs 172028 a disintegnn and metalloprotease domain 1 1

130524 U89995 Hs 159234 forkhead box E1 1 1

133000 U24152 Hs 62402 p21/Cdc42/Rac1-actιvated kinase 1 (yeast 1 1

133658 M25756 Hs 75426 secretogran II (chromogranin C) 1 1

135047 AA460466 Hs 93597 ESTs 1 1

100053 M27830 AFFX control 28S πbosomal RNA 088 1 53

100114 D00596 Hs 82962 thymidylate synthetase 068 1 86

100128 D11094 Hs 61153 proteasome (prosome, macropain) 26S subu 1 29 203

100154 D14657 Hs 81892 KIAA0101 gene product 071 426

100161 D14694 Hs 77329 phosphatidylsenne synthase 1 1 02 1 56

100168 D14874 Hs 394 adrenomedullin 046 1 17

100187 D17793 Hs 78183 aldo-keto reductase family 1, member C3 1 1

100188 D21063 Hs 57101 mimchromosome maintenance deficient (S 097 1 4

100217 D26600 Hs 89545 proteasome (prosome, macropain) subunit, 1 13 1 9

100220 D28364 """Human mRNA for annexin II, 5 UTR (seq 1 11 1 53

100287 D43950 Hs 1600 chaperomn containing TCP1, subunit 5 (e 1 13 209

100297 D49489 Hs 182429 protem disulfide isomerase related prat 092 78

100330 D55716 Hs 77152 mimchromosome maintenance deficient (S 1 07 1 61

100355 D78129 """Homo sapiens mRNA for squalene epoxid 096 1 87

100364 D78586 Hs 154868 carbamoyl phosphate synthetase 2 aspart 1 49 246

100368 D79987 Hs 153479 extra spindle poles, S cerevisiae, homo 059 1 32

100398 D84557 Hs 155462 mimchromosome maintenance deficient (mi 1 08 1 9

100438 D87448 Hs 91417 topoisomerase (DNA) II binding protein 1 2 15 100455 D87953 Hs 75789 N-myc downstream regulated 091 1 48

100491 HG1153 HT1153 Nucleoside Diphosphate Kinase Nm23-H2s 099 1 41

100518 HG174-HT174 Desmoplakin I 1 28 317

100528 HG1828-HT1857 """Nexiπ, Glia-Denved""" 068 1 9

100661 HG2874-HT3018 Ribosomal Protein L39 Homolog 1 1 544

100667 HG2981-HT3127 """Epican, Alt Splice 11""" 08 1 97

100830 HG4074-HT4344 Rad2 1 01 212

101061 K03515 Hs 944 glucose phosphate isomerase 091 1 79

101131 L10838 Hs 167460 splicing factor, argmine/senne rich 3 1 23 1 87

101162 L14595 Hs 174203 solute carrier family 1 (glutamate/neutr 1 35 273

101181 L19686 Hs 73798 macrophage migration inhibitory factor ( 1 03 1 78

101183 L19779 HS 795 H2A histone family, member O 057 1 3

101216 L25876 Hs 84113 cyclin-dependent kinase inhibitor 3 (CDK 07 22

101228 L27706 Hs 82916 chaperonin containing TCP1 , subunit 6A ( 099 1 99

101233 L29008 Hs 878 sorbitol dehydrogenase 082 2 11

101247 L33801 Hs 78802 glycogen synthase kinase 3 beta 1 2 1 91

101332 L47276 """Homo sapiens (cell line HL 6) alpha t 069 278

101342 L76191 Hs 182018 ιnterleukιn-1 receptor-associated kinase 1 04 1 84

101396 M15796 Hs 78996 proliferating cell nuclear antigen 095 355

101423 M18391 Hs 89839 EphA1 1 1 5

101445 M21259 Hs 1066 small nuclear πbonucleoprotein polypept 1 21 1 96

101505 M27396 Hs 75692 asparagine synthetase 093 1 6

101525 M29536 Hs 12163 eukaryotic translation initiation factor 1 19 1 93

101535 M30448 Hs 251669 casein kinase 2, beta polypeptide 096 1 42

101607 M38690 Hs 1244 CD9 antigen (p24) 1 11 1 25

101624 M55998 """Human alpha-1 collagen type I gene, 3 1 17 1 98

101758 M77836 Hs 79217 pyrrolme 5-carboxylate reductase 1 1 77 345

101839 M93036 Hs 692 membrane component, chromosomal 4, surfa 071 1 45

101853 M94362 Hs 76084 lamin B2 084 1 19

101977 S83364 """putaiive Rab5-mteractmg protein fcl 089 1 9

101992 U01038 Hs 77597 polo (Drosophιa)-lιke kinase 066 1 46

102009 U02680 Hs 82643 protein tyrosine kinase 9 1 23 3 35

102012 U03057 Hs 118400 singed (Drosophιla)-lιke (sea urchin fas 085 1 88

102039 U05861 Hs 201967 aldo keto reductase family 1, member C1 093 2 32

102123 U14518 Hs 1594 centromere protein A (17kD) 1 428

102130 U15009 Hs 1575 small nuclear nbonucleoprolein D3 polyp 089 1 42

102148 U16954 Hs 75823 ALL1-fused gene from chromosome 1q 08 295

102210 U23028 Hs 2437 eukaryotic translation initiation factor 1 01 1 34

102220 U24389 Hs 65436 lysyl oxidase like 1 1 15 2 34

102260 U28386 Hs 159557 karyopheπn alpha 2 (RAG cohort 1, impor 1 14 2 69

102330 U35451 Hs 77254 chromobox homolog 1 (Drosophila HP1 beta 1 05 1 7

102423 U44754 Hs 179312 small nuclear RNA activating complex, po 1 14 299

102455 U48705 Hs 75562 discoidm domain receptor family, member 1 05 201

102499 U51478 Hs 76941 ATPase, Na+/K+ transporting, beta 3 poly 1 27 1 92

102522 U53347 Hs 183556 solute carrier family 1 (neutral ammo a 084 1 31

102590 U62136 """Homo sapiens enterocyte differentiati 1 11 1 6

102676 U72514 Hs 12045 putaiive protein 1 04 2 17

102687 U73379 Hs 93002 ubiquitm carrier protein E2-C 086 228

102704 U76638 Hs 54089 BRCA1 associated RING domain 1 1 12 1 63

102781 U83843 """Human HIV-1 Nef interacting protein ( 09 1 39

102784 U85658 Hs 61796 transcnption factor AP-2 gamma (activat 098 2 16

102827 U91327 Hs 6456 chaperonin containing TCP1, subunit 2 (b 096 1 62

102935 X13482 Hs 80506 small nuclear πboπucleoprotein polypept 1 21 42

102972 X16662 Hs 87268 annexm A8 1 25 232

102983 X17620 Hs 118638 non-metastatic cells 1, protein (NM23A) 1 03 1 83

103023 X53793 Hs 117950 multifunctional polypeptide similar to S 1 58 544

103038 X54941 Hs 77550 CDC28 protein kmase 1 1 32 379

103075 X59543 Hs 2934 πbonucleotide reductase M1 polypeptide 1 11 258

103168 X68314 Hs 2704 glutathione peroxidase 2 (gastrointestm 075 305

103185 X69910 Hs 74368 transmembrane protein (63kD), endoplasmi 1 01 1 97

103212 X73874 Hs 2393 phosphorylase kinase, alpha 1 (muscle) 095 1 72

103223 X74801 Hs 1708 chaperonin containing TCP1, subunit 3 (g 097 1 77

103260 X78416 Hs 3155 casein, alpha 1 1

103262 X78565 Hs 204133 hexabrachion (tenasc C, cytotactin) 1 23 3 09

103330 X85373 Hs 77496 small nuclear nbonucleoprotein polypept 1 12 225

103364 X90872 Hs 75854 SULT1 C sulfotransferase 285 462

103375 X91868 Hs 54416 sine oculis homeobox (Drosophila) homolo 1 248

103391 X94453 Hs 114366 pyrralme-5-carboxylatβ synthetase (glut 1 1 53

103404 X95586 Hs 78596 proteasome (prosome, macropain) subunit, 092 1 53

103437 X98260 Hs 82254 M phase phosphoprotein 11 092 1 54

103448 X99133 Hs 204238 lipocalin 2 (oncogene 24p3) 055 0 96

103605 Z35402 Hs 194657 cadheπn 1, E-cadheπn (epithelial) 1 32 251

103646 Z68228 Hs 2340 junction plakoglobm 088 1 28

103658 Z74615 Hs 172928 collagen, type I, alpha 1 1 06 298

103774 AA092898 Hs 92918 ESTs, Weakly similar to R07G3 8 [C elega 1 88 466

104261 AF008442 Hs 5409 RNA polymerase I subunit 087 217

104276 C02193 Hs 85222 ESTs, Weakly similar to R27090 [H sapi 14 249

104289 C16281 Hs 75478 KIAA0956 protein 1 15 1 68

104434 L02870 Hs 1640 collagen, type VII, alpha 1 (epidermolys 1 04 1 49

104453 M19169 Hs 123114 cystatin SN 038 076

104611 R98280 Hs 125845 rιbulose-5 phosphate-3-epιmerase 1 08 2 25

104758 AA024661 Hs 7010 ESTs, Weakly similar to ACYL-COA DEHYDRO 1 14 1 65

105114 AA156532 Hs 11801 adenosine A2b receptor pseudogene 091 1 38

105132 AA159501 Hs 247280 HBV associated factor 1 08 1 7

105174 AA186613 Hs 34744 ESTs 095 205 105280 AA232215 Hs.14600 ESTs 1 1.4

105344 AA235303 Hs.8645 ESTs 0.72 2.02

105516 AA257971 Hs.21214 ESTs 1.35 3.56

105621 AA280865 Hs.6375 Homo sapiens mRNA; cDNA DKFZp564K0222 (f 1.23 1.82

105698 AA287393 Hs.15202 ESTs; Weakly similar to oligodendrocyte- 0.98 1.28

105705 AA290767 Hs.101282 Homo sapiens mRNA; cDNA DKFZp434B102 (fr 0.92 1.32

105724 AA292098 Hs.22934 ESTs; Weakly similar to ZINC FINGER PROT 0.99 1.41

105782 AA350215 Hs.21580 ESTs 1 1

105799 AA372018 Hs.24743 ESTs 1.08 1.78

105807 AA393803 Hs.16869 ESTs; Moderately similar to COLLAGEN ALP 0.95 1.34

105891 AA400768 Hs.26662 ESTs; Weakly similar to tumor necrosis f 0.87 2.25

105936 AA404338 ESTs 1.14 1.46

106069 AA417741 Hs.29899 ESTs; Weakly similar to ZINC FINGER PROT 1 1

106103 AA421104 Hs.12094 ESTs 1.04 1.44

106140 AA424524 Hs.14912 KIAA0286 protein 1.23 2.11

106149 AA424881 Hs.256301 ESTs 0.83 1.48

106154 AA425304 Hs.6994 ESTs 0.77 2.05

106182 AA426609 Hs.10862 ESTs 0.74 2.23

106220 AA428582 Hs.32196 ESTs; Moderately similar to metargidin p 0.97 1.99

106228 AA429290 Hs.17719 ESTs 0.99 1.54

106318 AA436570 Hs.9605 pre-mRNA cleavage factor Im (25kD) 0.95 2.09

106341 AA441798 Hs.5243 ESTs; Moderately similar to plL2 hypothe 0.98 2.66

106432 AA448850 Hs.17138 ESTs 0.95 1.93

106474 AA450212 Hs.42484 Homo sapiens mRNA; cDNA DKFZp564C053 (fr 1 1

106483 AA451676 Hs.30299 IGF-II mRNA-binding protein 2 1.4 2.29

106599 AA457235 Hs.12842 ESTs; Moderately similar to non-function 1 1.82

106611 AA458904 Hs.26267 ESTs; Weakly similar to torsinA [H.sapie 1.49 2.78

106654 AA460449 Hs.3784 ESTs; Highly similar to phosphoserine am 1 1.4

107076 AA609145 Hs.21143 ESTs; Weakly similar to fos39554_1 [H.sa 1.11 1.49

107115 AA610108 Hs.27693 ESTs; Highly similar to CGI-124 protein 1 1.03

107129 AA620553 Hs.4756 flap structure-specific endonuclease 1 1.13 3.63

107159 AA621340 Hs.10600 ESTs; Weakly similar to ORF YKR081c [S.c 1.05 2.09

107444 W28391 Hs.5181 proliferation-associated 2G4; 38kD 1.18 1.9

107481 W58247 Hs.27437 Homo sapiens kinesin superfamily motor K 0.99 2.74

107516 X56597 Hs.99853 fibrillarin 0.94 1.77

107529 Y12065 Hs.5092 nucleolar protein (KKE/D repeat) 1.05 2.29

107531 Y13936 Hs.17883 protein phosphatase 1G (formerly 2C); ma 1.06 1.62

107801 AA019433 Hs.173100 ESTs 1.03 1.4

107957 AA031948 Hs.57548 ESTs 0.95 1.46

108565 AA085342 Hs.1526 ATPase; Ca++ transporting; cardiac muscl 0.59 1.35

108780 AA128561 Hs.117938 collagen; type XVII; alpha 1 1 7.63

108828 AA131584 Hs.71435 DKFZP564O0463 protein 1.33 2.56

109060 AA160879 Hs.241551 chloride channel; calcium activated; fam 0.67 1.42

109112 AA169379 Hs.72865 ESTs 1.03 2.31

109344 AA213696 Hs.86559 poly(A)-binding protein-like 1 0.97 1.55

109412 AA227145 Hs.209473 ESTs; Weakly similar to REGULATOR OF MIT 0.76 1.87

110780 N23174 Hs.22891 solute carrier family 7 (cationic amino 0.9 0.95

110958 N50550 Hs.24587 signal transduction protein (SH3 contain 1.17 2.26

111018 N54067 Hs.3628 mitogen-activated protein kinase kinase 1.21 1.85

111337 N79612 Hs.16607 ESTs; Highly similar to Myosin heavy cha 1 1.45

112305 R54822 Hs.26244 ESTs 1 1

112401 R61279 Hs.237536 ESTs; Weakly similar to F25B5.3 [C.elega 1.24 1.64

112853 T02843 Hs.4351 EST 1.56 1.96

112869 T03313 Hs.4747 dyskeratosis congenita 1; dyskerin 1.03 1.57

112992 T23513 Hs.7147 ESTs 1 1

113048 T25895 Hs.184008 ESTs; Weakly similar to RNA-binding prat 1.37 2.26

113063 T32438 Hs.5027 ESTs 1 1

113179 T55182 Hs.152571 ESTs; Highly similar to IGF-II mRNA-bind 1.33 2.7

113573 T91166 Hs.15990 ESTs 0.76 1.47

113811 W44928 Hs.4878 ESTs 0.79 1.51

114086 Z38266 Hs.12770 Homo sapiens PAC clone DJ0777O23 from 7p 0.9 1.34

114587 AA070827 Hs.180320 ESTs; Weakly similar to GOLGI 4-TRANSMEM 1.02 1.76

114846 AA234929 Hs.44343 ESTs 1.32 2.36

114964 AA243873 Hs.82184 ring finger protein 3 1.1 1.84

115047 AA252627 Hs.22554 homeo box B5 1.01 2.36

115166 AA258409 Hs.198907 myelin protein zero-like 1 1.05 2.31

115167 AA258421 Hs.43728 hypothetical protein 1.52 2.52

115239 AA278650 Hs.73291 ESTs; Weakly similar to similar to the b 0.7 2.57

115278 AA279757 Hs.67466 ESTs; Weakly similar to BACN32G11.d [D.m 1.14 2.12

115652 AA405098 Hs.38178 ESTs 0.82 4.67

115875 AA433943 Hs.43946 ESTs; Weakly similar to Weak similarity 1.2 1.98

116004 AA449122 Hs.76086 ESTs; Highly similar to small zinc tinge 0.96 1.31

116121 AA459254 Hs.48855 ESTs 0.97 1.55

116129 AA459956 Hs.49163 ESTs; Highly similar to putative ribonuc 1.08 2.73

116190 AA464963 Hs.67776 ESTs 0.8 1.57

116312 AA490494 Hs.65403 ESTs 1.37 2.65

116732 F13779 Hs.165909 ESTs 0.92 1.8

117602 N35020 Hs.44685 ESTs; Weakly similar to GOLIATH PROTEIN 1.15 1.84

117950 N51394 Hs.75478 KIAA0956 protein 1.04 2.36

117992 N52000 Hs.172089 Homo sapiens mRNA; cDNA DKFZp586B0222 (f 0.62 1.29

118785 N75386 Hs.111867 GLI-Kruppel family member GLI2 1 1

119717 W69134 Hs.57987 ESTs 1 1.4

119814 W74069 Hs.58350 ESTs 0.78 1.77

120128 Z38499 Hs.91448 MKP-1 like protein tyrosine phosphatase 0.86 1.46

120242 Z98443 Hs.86366 ESTs 0.83 2.01 120483 AA252994 Hs.1578 apoptosis inhibitor 4 (survivin) 0.74 1.64

121054 AA398604 Hs.97387 ESTs 1.05 1.93

121326 AA404246 Hs.97031 ESTs; Weakly similar to Similar to phyto 0.98 1.3

121376 AA405699 Hs.166232 ESTs; Moderately similar to SODIUM- AND 0.91 1.83

121457 AA411448 Hs.208985 ESTs 0.91 1.59

121780 AA422086 Hs.124660 ESTs 0.46 0.55

121781 AA422150 Hs.98370 cytochrome P540 family member predicted 1.07 1.54

121844 AA425732 Hs.98485 gap junction protein; beta 2; 26kD (conn 0.94 1.4

122059 AA431737 Hs.98749 EST 1.93 2.33

122338 AA443311 Hs.98998 ESTs 1 1

122354 AA443772 Hs.186692 ESTs 0.88 1.39

122591 AA453265 Hs.99311 ESTs; Weakly similar to MRJ [H.sapiens] 2.28 2.93

122790 AA460156 Hs.99556 ESTs 0.88 1.3

123398 AA521265 Hs.105514 ESTs 1 1.93

123518 AA608531 Hs.170313 ESTs 1 1

123673 AA609471 Hs.112712 ESTs 1 1.15

124000 D57317 Hs.74861 activated RNA polymerase II transcriptio 0.74 1.12

124367 N24006 Hs.99348 distal-less homeo box 5 0.67 1.1

124447 N48000 Hs.140945 Homo sapiens mRNA; cDNA DKFZp586L141 (fr 1.19 1.7

125756 W25498 Hs.81634 ATP synthase; H+ transporting; mitochond 0.93 1.59

125769 AI382972 Hs.82128 5T4 oncofetal trophoblast glycoprotein 1.65 6.76

125852 H09290 Hs.76550 Homo sapiens mRNA; cDNA DKFZp564B1264 (f 0.72 2.26

125924 AA526849 Hs.82109 syndecan 1 1.22 2.25

126037 M85772 Hs.6066 KIAA1112 protein 1.36 1.63

126214 N29455 Hs.74316 desmoplakin (DPI; DPII) 1.93 3.55

126414 N78770 Hs.223439 ESTs 1.21 1.66

126737 AA488132 Hs.62741 ESTs 1 1

126743 AA179253 Hs.172182 poly(A)-binding protein; cytoplasmic 1 1.3 2.16

126926 AA179546 Hs.832 ESTs; Highly similar to INTEGRIN BETA-8 2.53 2.8

127432 AA501734 Hs.170311 heterogeneous nuclear ribonucleoprotein 1.57 2.12

128218 H02682 Hs.99189 ESTs; Moderately similar to recombinatio 1.24 2.09

128527 M31523 Hs.101047 transcription factor 3 (E2A immunoglobul 1.08 1.78

128568 X60673 Hs.247568 adenylate kinase 3 1.23 3.48

128584 M11433 Hs.101850 retinol-binding protein 1; cellular 0.87 2.42

128628 C14037 Hs.251978 EST 1.22 1.9

128691 W27939 Hs.103834 ESTs 1.1 1.73

128714 V00599 Hs.179661 Homo sapiens clone 24703 beta-tubulin mR 0.92 1.17

128733 AA328993 Hs.104558 ESTs 1.34 1.94

128781 X85372 Hs.105465 small nuclear ribonucleoprotein polypept 0.9 1.34

129052 AA496297 Hs.182740 ribosomal protein S11 2.59 3.19

129095 L12350 Hs.108623 thrombospondin 2 1.04 3.2

129241 AA435665 Hs.109706 ESTs; Moderately similar to HN1 [M.muscu 0.95 1.61

129665 M88458 Hs.118778 KDEL (Lys-Asp-Glu-Leu) endoplasmic relic 1.28 2.63

129703 AA401348 Hs.179999 ESTs 0.97 1.63

129720 AA476582 Hs.12152 ESTs; Moderately similar to SIGNAL RECOG 1.09 1.79

129850 N20593 Hs.56845 GDP dissociation inhibitor 2 0.74 1.68

129896 AA043021 Hs.13225 UDP-Gal:betaGlcNAc beta 1;4- galactosylt 1.43 4.19

130069 AA055896 Hs.146428 collagen; type V; alpha 1 1.17 1.98

130405 H88359 Hs.155396 nuclear factor (erythroid-derived 2)-lik 1.26 1.79

130541 X05608 Hs.211584 neurofilament; light polypeptide (68kD) 1 1

130599 M91670 Hs.174070 ubiquitin carrier protein 1.07 1.66

130867 J04093 Hs.2056 UDP glycosyltransferase 1 1 4.8

131009 AA063596 Hs.22142 ESTs; Weakly similar to NADH-CYTOCHROME 0.93 1.05

131028 U20240 Hs.2227 CCAAT/enhancer binding protein (C/EBP); 1 1.23

131083 U66661 Hs.22785 gamma-aminobutyric acid (GABA) A recepto 1.1 1.8

131091 T35341 Hs.22880 ESTs; Highly similar to dipeptidyl pepti 1.28 1.98

131144 C14412 Hs.23528 ESTs; Highly similar to HSPC038 protein 1.43 2.06

131148 C00038 Hs.23579 ESTs 0.88 3.38

131164 Y00503 Hs.182265 keratin 19 1.19 2.77

131185 M25753 Hs.23960 cyclin B1 0.86 3.84

131219 C00476 Hs.24395 small inducible cytokine subfamily B (Cy 0.66 2.96

131454 AA455896 Hs.2699 glypicaπ 1 0.99 1.54

131687 L11066 Hs.3069 heat shock 70kD protein 9B (mortalin-2) 1 1.18

131689 AA599653 Hs.30696 transcription factor-like 5 (basic helix 1 1.95

131692 D50914 Hs.30736 KIAA0124 protein 1.55 2.39

131786 AA135554 Hs.32125 ESTs 1 1.33

131843 AA195893 Hs.184062 ESTs; Moderately similar to putative Rab 0.83 1.63

131860 U02082 Hs.334 Oncogene TIM 1.08 2.2

131884 H90124 Hs.3463 πbosomal protein S23 1.23 1.24

131903 AA481723 Hs.3436 deleted in oral cancer (mouse; homolog) 0.91 1.18

131945 M87339 Hs.35120 replication factor C (activator 1) 4 (37 1 2.8

131958 AA093998 Hs.3566 ESTs; Highly similar to phosphorylation 0.87 1.36

131964 W42508 Hs.3593 ESTs 1 1.25

132001 J00277 Hs.37003 v-Ha-ras Harvey rat sarcoma viral oncoge 1.12 1.43

132040 AA146843 Hs.172894 BH3 interacting domain death agonist 1 1.55

132065 D82226 Hs.211594 proteasome (prosome; macropain) 26S subu 0.89 1.27

132109 AA599801 Hs.40098 ESTs 1 1.05

132112 AA150661 Hs.40154 ju onji (mouse) homolog 0.99 1.44

132123 AA447123 Hs.250705 ESTs 1.06 2.46

132162 H89551 Hs.41241 ESTs 1.08 2.46

132180 AA405569 Hs.418 fibroblast activation protein; alpha; se 1.02 4.56

132309 AA460917 Hs.2780 jun D proto-oncogene 1.16 1.8

132371 AA235448 Hs.46677 ESTs 0.8 1.26

132618 AA253330 Hs.5344 adaptor-related protein complex 1; gamma 0.5 1.49

132736 U68019 Hs.211578 MAD (mothers against decapentaplegic; Dr 1.21 1.81 132771 AA488432 Hs.56407 phosphoserine phosphatase 1 1.3

132833 U78525 Hs.57783 eukaryotic translation initiation factor 0.91 1.43

132922 T23641 Hs.6066 KIAA1112 protein 1.16 1.53

132959 AA028103 Hs.61472 ESTs; Weakly similar to unknown [S.cerev 1.02 1.88

132994 AA505133 Hs.7594 solute carrier family 2 (facilitated glu 0.72 2.97

133005 C21400 Hs.103329 KIAA0970 protein 0.88 1.34

133065 X62535 Hs.172690 diacylglycerol kinase; alpha (80kD) 0.93 1.23

133083 N70633 Hs.6456 chaperonin containing TCP1; subunit 2 (b 1.14 1.76

133086 L17131 Hs.139800 high-mobility group (nonhistone chromoso 0.97 1.43

10 133134 T89703 Hs.65648 RNA binding motif protein 8 1.1 1.8

133195 AA350744 Hs.181409 KIAA1007 protein 2.29 2.69

133313 AA249427 Hs.70704 ESTs 1.07 1.68

133331 T62039 Hs.158675 ribosomal protein L14 0.85 1.18

133438 D13370 Hs.73722 APEX nuclease (multifunctional DNA repai 0.91 1.45

15 133445 T99303 Hs.73797 guaπine nucleotide binding protein (G pr 0.94 1.68

133483 X52426 Hs.74070 keratin 13 0.85 1.14

133492 L40397 Hs.74137 transmembrane trafficking protein 1.1 1.69

133504 W95070 Hs.74316 desmoplakin (DPI; DPII) 0.7 6.21

133517 X52947 Hs.74471 gap junction protein; alpha 1; 43kD (con 0.95 1.3

20 133540 D78151 Hs.74619 proteasome (prosome; macropain) 26S subu 0.91 1.25

133594 L07758 Hs.172589 nuclear phosphoprotein similar to S. cer 0.84 1.29

133627 U09587 Hs.75280 glycyl-tRNA synthetase 1.09 1.99

133671 T25747 Hs.75471 zinc finger protein 146 1.02 1.5

133859 U86782 Hs.178761 26S proteasome-associated padl homolog 1.11 3.33

25 133865 F09315 Hs.170290 discs; large (Drosophila) homolog 5 1.84 6.7

133913 W84712 Hs.7753 calumenin 1.15 1.86

133963 L34587 Hs.184693 transcription elongation factor B (Sill) 1.3 1.91

133982 U47621 Hs.207251 nucleolar autoantigen (55kD) similar to 1.3 1.99

134100 L07540 Hs.171075 replication factor C (activator 1) 5 (36 0.72 1.65

30 134110 U41060 Hs.79136 LIV-1 protein; estrogen regulated 1.04 1.62

134158 U15174 Hs.79428 BCL2/adenovirus E1B 19kD-inleracting pro 1 1.55

134161 U97188 Hs.79440 IGF-II mRNA-biπding protein 3 0.82 1.95

134193 F09570 Hs.7980 ESTs 0.98 1.48

134367 X54199 Hs.82285 phosphoribosylglycinamide formyltransfer 1 2.8

35 134402 U25165 Hs.82712 fragile X mental retardation; autosomal 1.26 2

134457 D86963 Hs.174044 dishevelled 3 (homologous to Drosophila 1 1.47

134469 X17567 Hs.83753 small nuclear ribonucleoprotein polypept 0.94 1.57

134498 M63180 Hs.84131 ^' threonyl-tRNA synthetase 1.2 2.64

134501 W84870 Hs.211568 eukaryotic translation initiation factor 0.84 1.36

40 134507 M63488 Hs.84318 replication protein A1 (70kD) 1.7 2.93

134548 U41515 Hs.85215 Deleted in split-hand/split-foot 1 regio 1.46 2.73

134599 X99226 Hs.86297 Fanconi anemia; complementation group A 1.36 2.22

134692 R73567 Hs.8850 a disintegrin and metalloproteinase doma 0.77 1.64

134693 N70361 Hs.8854 ESTs 1.09 1.82

45 134806 Z49099 Hs.89718 spermine synthase 0.98 1.35

134821 Z34974 Hs.198382 plakophilin 1 (ectodermal dysplasia skin 0.99 1.4

134864 Y08999 Hs.90370 actin related protein 2/3 complex; subun 0.95 1.42

134914 U29615 Hs.91093 chitinase 1 (chitotriosidase) 1.16 1.29

134953 L10678 Hs.91747 profilin 2 0.95 1.76

50 134993 AA282343 Hs.9242 purine-rich element binding protein B 0.98 1.73

135051 C15324 Hs.93668 ESTs 1.35 2.11

135158 U51711 Human desmocollin-2 mRNA; 3' UTR 0.86 1.16

Table 1 B shows the accession numbers for those pkeys in Table 1 A lacking unigenelD's. For each probeset we have listed the gene cluster number from which the 55 oligonucleotides were designed. Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs. These sequences were clustered based on^' sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California). The Genbank accession numbers for sequences comprising each cluster are listed in the Accession column.

Pkey: Unique Eos probeset identifier number

60 CAT number; Gene cluster number

Accession: Genbank accession numbers

Pkey CAT Accessions

65 100661 23182J BE623001 L05096 AA383604 AW966416 N53295 AA460213 AW571519 AA603655

100667 26401 3 L05424 X56794 S66400 X55150 W60071 AW351820 X55938 M83326 BE005289 BE070059 M83324 BE005248 BE069717 BE181648 BE069700

AW606203 BE069721 AW382138 AW803776 BE463954 BE005334 BE005274 T2738S AA932714 AA972695 AW377728 AI632506 T29066 AI783934 AW377727 BE163715 AL047291 AA279047 AA523003 BE008048 BE440141 W23614 BE090519 BE092193 N29181 N20358 N44153 __n BE546944 T69231 AW377441 AA907406 H50799 AW051416 AI420712 BE620922 AI279161 AA992549 W47198 BE005241 AI342696 H50700

70 AI969974 AI863855 AA374490 AW130675 AI950633 AA146687 H99482 X55150 BE005414 BE005339 N28294 AI673068 AI887890 AW804171

AI675961 AW804172 AA778841 AL048050 AI127757 AI095568 AW204965 AW468978 W31898 AI052595 AI278771 BE464018 AI081503 AI824196 AA513211 AA411062AW084376 N48752 AA703209 N35580 AW059918 AA054563 A1280942 T27619 BE621435 N66010 AW589527 AI160414 AA283090 AA962536 H82726 W52115 W45432 W60433 AA577548 AA146714 BE150994 AA054615 AW796025 AW382768 BE565671 C00444 AA054555 75 100668 26401 L05424X56794 S66400 X55150 W60071 AW351820 X55938 M83326 BE005289 BE070059 M83324 BE005248 BE069717 BE181648 BE069700

AW606203 BE069721 AW382138 AW803776 BE463954 BE005334 BE005274 T27386 AA932714 AA972695 AW377728 AI632506 T29066 AI783934 AW377727 BE163715 AL047291 AA279047 AA523003 BE008048 BE440141 W23614 BE090519 BE092193 N29181 N20358 N44153 BE546944 T69231 AW377441 AA907406 H50799 AW051416 AI420712 BE620922 AI279161 AA992549 W47198 BE005241 AI342696 H50700 „ _ AI969974 AI863855 AA374490 AW130675 A1950633 AA146687 H99482 X55150 BE005414 BE005339 N28294 A1673068 AI887890 AW804171

80 AI675961 AW804172AA778841 AL048050 AI127757 A1095568 AW204965 AW468978 W31898 AI052595 A1278771 BE464018AI081503AI824196

AA513211 AA411062 A 084376 N48752 AA703209 N35580 AW059918 AA054563 AI280942 T27619 BE621435 N66010 AW589527 A1160414 AA283090 AA962536 H82726 W52115 W45432 W60433 AA577548 AA146714 BE150994 AA054615 AW796025 AW382768 BE565671 C00444 AA054555 101332 25130J J04088 NM_001067AF071747AJ011741 N85424 AL042407AA218572 BE296748 BE083981 AL040877AW499918AW675045 H17813

85 BE081283 AA670403 AW504327 BE094229 AA104024 AI471482 AI970337 AA737616 AI827444 AW003286 AI742333 AI344044 AI765634 AI948838 AW235336 AW172827 AA095289 BE046383 AI734240 W16699 AI660329 AI289433 AA933778 AW469242 AA468838 AA806983 AA625873 W78031 BE206307 AA550803 AI743147 AI990075 AA948274 AA129533 AI635399 AA605313 AI624669 AW594319 AI221834 AI337434 AA307706 BE550282 AI760467 AI630636 AI221521 AW674314 AW078889 AI933732 AI686969 Al 186928 AW074595 AH 27486 AL079644 AI910815 H17814 AA310903 AW137854 T19279 AA026682 AA306035 AW383390 AW383389 AW383422 AW383427 AW383395 H09977 5 AA306247 AA352501 AW403639 F05421 AA224473 AA305321 H93904 AA089612 AW391543 AW402915 AW173382 AW402701 AW403113

R94438 N73126 H93466 AA090928 AA095051 T29025 AW951071 L47277 L47276 AI375913 BE384156 W24652 AA746288 AA568223 BE090591 H93033 N57027 AA504348 AA327653 AW959913 N53767 AA843715 AI453437 AW263710 AI076594 AA583483 AW873194 AW575166 AI128799 AI803319 AL042776 AW074313 AI887722 AI032284 AA447521 A1123885 N29334 AI354911 AW090687 AA236763 AA435535 AA236910 AA047124 AA236734AW514610 H93467 AA962007 AI446783 AA127259 AI613495 AI686720 AI587374 AA936731 AA702453 AI859757 10 AA216786 A1251819 AI469227 AA806022 AI092324 N71868 AA968782 AA236919 AA809450 AA227220 AA765284 AH 92007 AA768810

AA805794 AA729280 AA806238 AW768817 N71879 AI050686 AA505822 AA668974 A1688160 BE045915 AW466315 AA731314 AA649568 AA834316 AW591901 AW063876 AW294770 AI300266 AI336094 AI560380 AA721755 H09978 D20305 D29155 AW821790 BE150864 F01675 AI457474 AW466316 AA550969 AA630788 100780 458.127 BE561958 BE561728 BE397612 BE514391 BE269037 BE514207 BE562381 BE514256 BE514403 BE514250 BE397832 BE269598 BE559865

15 BE396881 BE560031 BE514199 BE560037 BE560454

100830 4002 AC004770 W05005 AA356068 AA094281 H29358 T56781 AW875313 L37374 BE312466 BE311755 BE207106 BE293320 BE018115 AW239090

BE548830 AW247547 AA776062 BE397382 AA486713 T10111 T09340 AW498981 BE547280 AA356003 AW581520 AW875331 AA580720 AW875336 BE276873 BE408229 AW188148 BE255166 BE253761 AW793727 AW373141 AW581548 AA471223 AA305950 BE263976 AA626820

_ . BE257409 AW360962 AA090655 C00312 BE312741 BE407213 AA209352 AW298199 AW248553 AW297794 AW731722 BE300586 AW731972

20 AW615446 BE301599AW615520AA486714AW440257AA196516AA564630AA618079 AW192592AW474985 AA604580AI627461 AA765440

AI680394 AL135548 AI683224 AI581126 AW245096 AW194154 H29274 N70363 AA629758 AA580602 AA862006 AI863841 AI097667 AI928583 AI358774 BE243487 AA620553 AA653297 AA292690 T10110 Z38906 AA908544 AA340930 AH 85438 T03328 T28844 AI687010 AI864965 AI872575 BE388740 T56780 AW373138 BE258717 AA699671 100906 4312J AU076916 BE298110 AW239395 AW672700 NM_003875 U10860 AW651755 BE297958 C03806 AI795876 AA644165 T36030 AW392852

25 AA446421 AW881866 AI469428 BE548103 T96204 R94457 N78225 AI564549 AW004984 AW780423 AW675448 AW087890 AA971454 AA305698

AA879433 AA535069 AI394371 AA928053 AI378367 N59764 A1364000 AI431285 T81090 AW674657 AW674987 AA897396 AW673412 BE063175 AW674408 AI202011 R00723 A1753769 AI460161 AW079585 AW275744 AI873729 D25791 BE537646 T81139 R00722 100930 16865J J04129 NM 002571 AA293088AA477016AA404631 T28299 AA476904 AA433965 AA430486 AA495907 Al 151391 AA291495 AA402723 25651

AA706816 AI826712 AW296294 AA293479 AI276581 AW044154 AI080180 AI417985 AI274168 AI474212 AA495908 AA635664 AI092114

30 AI804952 AA479874 AI597661 AI420511 AA479738 AA421417 AA421247 AA436220 AL047797 M34046 N42277 AA228076 W02698 AI420297

AA434011 AI369971 AA479731 AI865541 AI418020 AA421246 AA452764 AL048051 102221 3861J NMJ06769U24576AW161961 AW160473 AW160465 AW160472 AW161069 AI824831 AW162635 AI990356 A 162477 AW162571 AI520836

AW162352AW162351 AW162752AI962216AI537346AA853902 H17667 BE045346 BE559802 BE255391 AA985217AA235051 AI129757 AW366451 T34489 D56106 D56351 AI936579 AW023219 AW889335 AW889120 AW889232 AW889175 BE093702 AW889349 AA147546

35 AI952998 AA912579 AI143356 AW902211 R64717AW157236 AI815242 D45274 AW263991 AA442920 AA129965 AL035713 AI923255 AI949082

AI142826 AI684160 AI701987 AI678954 AI827349 BE463635 AW628092 AW302281 AA493203 BE348856 BE536419 AW193969 AW673561 AW592609 AI224044 H43943 AA091912 R49632 R48353 AI568409 R48256 AI198046 H27986 H43899 AI678759 AI680310 AI624220 H17052 AA156410 N56062 AI699430 AA664529 T09406 T10459 AA627506 AI379584 N83831 N88633 AW022651 AA971281 AA248036 AI039197 AI914689 AA973825 AL047305 AA129966 AI798369 AW264348 AI445879 AI658759 N67924 AI933507 AI216121 AI333174 T10972 AI375028

40 AH 86756 AI273778 AA610487 AI797946 AA853903 AA903939 AI338587 AI278494 AW627595 AA904019

101809 32963J M86849 AA315280 NM 004004 AA315269 BE142653 AA461400 AW802042 BE152893 AW383155 AA490688 AW117930 AW384563 AW384544

AW384566 AW378307 AW378323 AW839085 AA257102 AW378317 AW276060 AW271245 AW378298 AW384497 AI598114 AW264544 AI018136 AW021810AA961504AW086214AW771489AW192483AI290266AW192488AW384490AW007451 AW890895AA554460AA613715 . AW020066 AI783695 AI589498 AI917637 AW264471 AW384491 AI816732 AW368530 AW368521 AW368463 AA461087 AI341438 AI970613

45 A1040737 A1418400 AA947181 AA962716 AI280695 AW769275 AW023591 Al 160977 AA055400 N71882 AA490466AW243772AW316636

AI076554 AW511702 N69323 H88912 AA257017 AI952506 H88913 AI912481 AA600714 BE465701 N64149 C00523 N64240 AA677120 102590 15932.1 R61573 BE005029 X98091 AA297307 BE537267 BE566138 BE566139 F11561 BE564795 BE568776 AW064005 BE566479 BE380035 BE567012

BE568634 BE566568 AA298060 BE566043 BE568813 BE568618 AA283070 BE565414 BE566738 BE568585 BE565667 BE566116 BE566433

_ - U62136 AF049140 BE567057 BE567297 BE567403 BE564316 BE567400 BE568854 BE566588 AA448772 AA071363 AW732642 BE564996

50 AA297763 AA278550 AA421083 AA298184 AA091007 AA984577 AA205916 N28759 AL031291 C15757 C15761 H02728 BE566410 AA129335

AA419499 N87741 BE379689 BE004824 BE379611 D25874 AA148454 AA323654 AW950311 AA448795 AW749423 AA773386 AA773843 AW020327 BE348580 BE504258 BE549990 BE220200 AI673334 At202679 AA975515 D61421 A!168688 AA102843 AW246621 AI276203 AI074054 AI633824 AI962927 AI148926 N50969 AI308911 AA410994 AW373025 AA148455 H02620 AA688293 AI246318 N22220 AI917777

, , AI050943 AI097286 AA663794 AW368662 AW627826 AW078734 AI253060 AA749154 AA832236 AI192358 AW024676 AA448676 AA764891

55 BE439467 AA661534AA258061 AI090546 AA995157 AI051011 AA584421 AI026032AW591338AW589563AA776914AW024684AA421002

F09219 BE464500 AI383595 AA954244 AA601583 AA737304 AA195549 AA805778 AI055876 AA164942 AW013961 AI672608 AW514211 D59441 AW582574 AA160935 BE566501 BE564612 BE565353 BE568195 BE565447 BE568302 BE566097 BE565470 BE564249 AL036217 AW749424 BE567494 AA102842 AA314761 AV661237 C14211 AA651866AW798997 AA470605 101977 29073.1 AF112213 AL050318 T24804 AW248136 BE386341 BE263177 W16677 BE250224 BE563669 BE267405 BE546577 AV651354 AV651292

60 AI346903 AI539128 Al 189171 S83364 AW073849 AI816760 AW073309 AI422690 AA296692 AI860301 AI805446 N77735 AI340328 BE092530

AW028742 BE088442 AA657742 AA742438 AW170086 AI038920 AI432379 N36073 AI936194 AA868655 AA983612 AI077505 BE080433 AI375014 AI126547 AI348244 AI346077 AI748952 N26915 AI753574 AI093341 AI278762 BE092517 N74204 H06158 T58149 AI129303 N58366 AA524456 BE122661 AA542925 AI246120 AI735203 AA706829 AA877544 AI082289 AA926687 N92840 AW249798 AA934763 AW998363 AI128632 N25202 AI240209 AW118892 N80744 R35655 AI342321 AI340141 AW878792 AI857321 H09610 W04601 AW006650 AA126006

65 AA553675 AI052791 AW059835 AI041906 AA814658 AW002059 AA729483 AI609301 AA994633 AA903651 AI459183 T95072 AW088630

AA126112 AI800091 AI561215 H17502 AW475072 AI819003 AI683272 AI262701 AW793140 T81787 R99586 AI275160 AI310420 AI698929 AA159174 AI827968 F30305 F30309 AA806662 AI091923 AW878722 AA583430 AW571913 AI674584 AA292533 AI079471 AA642325 AA719050 AW793172 AA305476 AW103745 T23459 N79525 AI784438 AA534551 AW193751 AI074360 BE281214 T32229 W25066 W01205 T63086

_ _ A 795348 AI361287 AW795353 AW795349 AA594759 AI400295 D11489 A1370689 AA482356 AA485295 W40151 AA564661 AW300745

70 AI346938 AI374975 AI423782 AW193899 AA612604 AI183409 AA996156 AW366963 AW366977 AI284860 AA846503 AI985064 AA844576

AA737921 AA873274 BE241546 BE241540 AA484058 AW468970 AA127876 AA159120 AW001568 AW795213 AW795258 AW795330 BE250589 BE387572 AA910895 AA161217 BE250380 W31500 T95167 AI719306 AI359224 102781 20812.1 BE258778 BE281230 BE410044 T33723 AW672694 AW410439 NM 006429 AF026292 T35505 BE542333 T08940 AU076737 AW247471

BE393215 AW328640 BE542408 T32170 BE302544T31955 BE206898 BE275738 T32570 BE386426 BE298746 BE389937 BE293991 BE315289

75 BE389578 R34739 R15312 BE279365 BE277756 ALO36019 T33725 BE277779 BE302962 AL047294 BE276505 T09070 T33673 BE312580

AW387774 BE257175AW674367 BE253331 BE270344 BE299831 BE273576 T32062 A1751831 BE618381 AA304899 BE252268 U46364 BE256790 BE207199 BE256209 BE251941 BE250791 BE313955 BE269806 BE543623 BE279212 BE252289 T31699 BE262220 T31669 AA315781 AA192212 N84547 BE292737 BE259631 AA232179 A1133144T31292 AA315945 BE407301 BE251184 BE409006 At880158 AI904003

₀ AI904114 AW651768 AW651763 R58247 BE271897 U83843 C05298 BE261609 BE255973 AA351650 N84631 BE263637 AW452910 AA328465 oU AA324549AW579525 BE25229SBE257551 AL048332BE208630AA359336AW327897AA151742AA305816 BE076862 BE076796 BE263161

AA323785 AA676588 AA626565 AA078917 W87657 R09002 R94021 AA312032 BE276665 AA295608 AW407162 AA329374 AW877912 N27885 AA369256 AA360968 BE250476 N85427 BE265569 AI278639 AI816576 AI691037 AW328583 AI567949 AI983455 AI927732 AI811297 AI571508 AW073674 BE296039 BE467326 A1828796 AI816578 A 511604 AI921213 AW152427 AI795787 A1801618 AW168866 A1628144 AI890339

₀ _ AW173690 AW511540 BE535620 AA383014 BE301164 AI866596 AW514909 AA658050 AW575243 AA074631 AI093488 AW575408 AW675443

85 AW615636AW732207AW377638AA321784AA641629AA633105AA527640AW129146AW615672BE394607AA483902AW475032 BE378532 AA872808 AI469388 AW105268 BE047301 AW591843 AW410066 AW517153 AI950495 AA746641 AI914878 AA873185 A1696911 AA548625 AA911505 AA148762 AW674535 AI587329 BE328328 AW270348 AA158225 AW117705 AW474997 AW519193 AA614757 AW664383 AI082647 A 590973 AI476711 AA192213 N88741 BE464552 AW072679 A1453708 AA152166 AA805924 AI581078 AH 25768 AW173484 A1961980 BE300766 AH 99698 AI636792 AW247333 AW272861 AA078818 AA150012 AA551232 AA678821 AW873869 AW768266 AI660315 AA319210 AA814551 AA157994 AA318886 AI582962 AW089224 AI356098 AI343694 AW072598 N21054 AI301249 AA742924 H17917 AW328584 . AW248898 AI751830 AA907816 R08898 AW087989 AI828300 AA148596 AI269577 T33426 AA213571 AI973201 AA666279 R49612 AI573183 AW799762 AW410068 AW769666 AI962097 AI475204 D57490 AW517531 BE245270 AW470008 T33427 AW005731 AI795795 T23753 AW272981 T15747 AA552875 T23644 AW361289 AI758558 BE207435 AA876958 T03361 AA883569 F37533 AA582321 AW082524 R42212 AA973847 T18900 AA086202 AI559867 A1302418 AA948667 AA745670T08939T33724T33722 BE621568 D57489 D25906 BE621151 F16510 C05966 T35127 AA630427 AI933481 AA309426 AI918440 BE561854 BE618866 BE394675 BE296173 AW951687 BE383739 BE616141 BE312730 BE535351 AW080575 BE313330 BE616664 AI354390 AA847315 BE544509 BE515212 BE297833 BE278808 BE544844 AW090178 AI890664 BE546708 AW189943 BE274412 BE382399 BE266392 BE254949 BE280696 BE383237 BE261756 BE257721 BE312683 BE275476 BE514880 BE545314 BE313587 BE384537 BE386691 BE264813 AW592575 AI336332 A1278641 AI795791 BE222662 AW249316 AA314361 AL036012 AW402923 BE266845 AA075945 AA314436 BE384640 AW731769 AW957077 AA552234 AA573560 AW367038 AA313399 AI983873 BE410159 BE263803 BE514339 BE409073 BE281296 BE543396 BE395387 BE088360 BE546946 BE546570 BE390626 AA074638 AA301821 AW845230 AW582379 AI949222 AW029572 AA515843 AW272394 BE250234

119221 102947J C14322 74050 AI074232 AA595624 BE048955 AI148417 A1583145 A1473460 AI801688 A 573593 A1950741 AI628140 A 467921 R98105 AI149258 A1247584 AI078378 AI139850 AA489411 W24744 R98104 AI033826 AA699589 AI033120 N55544 W88984 AW970771 AA703362 AA099138 AA706792 AA046150 H98981 AI916674 AA953018 AI972749 AI921343 AA909044 AA094751 AI203124 AA582143 AI446654 AW235415 R70377 AA099236 F20703 AA524436 R69484

125831 1522905.1 H04043 D60988 D60337 128192 45743.3 AI204246 AI204250 Al 194050 113195 178688 1 H83265 T63524 AA304359 AW960551 AI672874 AI749427 AA227777 AW027055 AA971834 T49644 T54122 AI983239 AI808233 T91264 T96544 AI350945 AI709114 R72382 T48788 R48726 AW385418 AI095484 T49645 AA928653 AA570082 AW007545 T57178 AA516413 AA913118 T57112 AA564433 AA774503 AA367671 T59757

119861 238266 1 W78816 AI720806 AI633854 AI632086 AI668663 N70894 AW571809 AI383592 AI201348 W80715 N91880 AW963101 AA339011 112973 4868.1 AB033023 BE391906 BE275965 BE277872 BE003882 AA313774 BE019159 BE298024 BE299727 BE300011 BE390277 BE394764 N87550 BE409419 BE408652 BE408197AL119332AA622427AI816265 AA610118T07318AA019839AA634430 BE205794 BE049461 AI042322 AI652711 AI917645 AA630045 AW191969 AI817882 T17271 AI803663 AI095533 H46019 AW592438 AI624836 AI675652 D51149 AW132058 AA639614 AI925762 AW088153 T17455 AA018640 AW751475 BE300241 AI816255 BE391981 AW408671 AA353910 AW875446 AW875703 AW875926 AW875645 AW875647 AW938037 AL138042 AW892619 BE243018 AW995454 BE246381 BE009082 BE278921 AW967842 AA262454 H30121

129402 47367.1 W72062 AF088057 W76255 AI827219 AI631461 AW449295 AI354957 AI913803 T62772 AI222040 T62921 T63781 105936 260931.1 AI678765 H12175 R14664 AI914049 AA995383 H08009 H19418 AW953728 AI358021 AA587361 AI269377 AA369905 AW957113 H27693 AI300474 H73776 W74397 AA579604 AH 31018 W72331 AI719085 AA568348 AI859045 AI814819 AI888714 BE467470 AW131268 H19419 H27694AI342165AI914155AA534872 BE018176 R60206 H11647 R45641 A1860466 BE301656 AI125453 A!498120 AA593735 AA879110 AI016404 T35018 AA588397 AW449767 AA470365 BE501139 AA588354 AI337500 AW078532 Z41279 AI125449 AA935725 AA404338

129466 2094.50 L42583 NM.005554 L42601 BE183076 AI541221 BE140567 L42610 V01516 J00269 AW275792 AW383052 AW380143 AI541102 BE612846 AI541344 AW238368 BE613405 BE615705 BE615530 BE615301 AW379823 AW794706 AA194806 AA194992 AW384024 AW384000 AA641239 AI246504 AI540333 AW238681 AA640939 AI540863 AI608860 AW862564 AW366725 AW368983 AW366870 AA596020 AW794721 AW794511 AI591181 BE182523 AW794644 AW794620 AI935234 AI608903 AI608623 AW797060 AW084935 BE182517 BE182319 AI890082 AW238346 AW797012 BE182522 AW794838 AI608794 AW304289 AA147193 AA595995 AW381128 AW366720 AA583718 AI828416 BE122864 AW368343 AA431080 AW082039 AW380976 AA587144 AA443636 AW872937 AW794448 AW378382 AW085761 AW794718 AW263895 AA583587 AA583991 AA583994 AA586886 AA586880 AW368365 AI814460 AA586991 AI282829 AW378406 AA586721 AI609242 AA431973 AA232959 AI831095 AW263854 AW378391 AW378415 AW378381 AA036990 AW238395 AI285446 BE208219 BE049526 AA583605 AA583918 AW366711 AI285580 AW082642 AI285712 AA582875 AW591216 AW368719 AW378408 BE122835 AA582976 BE350422 AA418328 AI541454 AI565930 AA583700 AA150575 AW238427 AI287474 AA912658 AA584223 AW238528 C17918 AW136169 AA159847 AI923797 AI609009 BE182479 AI915198 AW378114 AA147179 AA584239 AA150532 AW168862 AW085999 AW082480 AA659742 AW079703 AI872793 AA583981 AI824571 BE182316 BE182507 AA233331 AI824572 AI540586 D29492 BE182931 AA036948 BE551821 D29401 AW378365 C00141 D29181 D29567 AW103359 W95238 AI991663 AA587298 BE184608 AA099833 W95121 W95150 D29584 AI934111 D29456 D29533 AW265380 D29290 AW238463 AA121041 D29204 AA595925 D29441 AW081840 AA587018 D29323 AA582891 BE182433 BE182437 BE158295 BE182434

100220 45374.1 AW015534 AA314369 AA290715 BE568683 AW629494 D28364 AW995678 100355 12538.1 AI907114 AA580734 AL041945 AA101515 AA121344 D78130 NM 003129 AA341650 T84166 AF098865 AA130976 BE089553 H05719 F13446 T66122 AW175590 F05344 AI114790 R12900 AA194871 AA132298 D78129 AA132213 AW948930 AW948919 AA263053 AW946593 AW948840 AA278558 R50895 N26940 N40818 AW021255 AA054851 AA663379 AW948795 AW948893 AA400356 AW948911 N85024 W78844 AI341546 AI760182 AA286783 BE617763 BE617263 AW263690 BE049454 BE617928 AW515038 AW950584 AA601009 AI079194 AA147204 AW083163 AA130981 AI218369 AA604784 AI806257 AI559556 AA232318 AA258065 AI471982 AA687949 AI143944 N30172 AA400196 AI769049 AI084342 AI221380AA948469AI802469H05720AA113270AA158138AA076231 AI521024AI810962AI133616AA805106AA101516 R40052R50778 R43280 T65036 AW131924 AA114251 AA152331 F09650 AA580614 AA558927 C75491 Z38352 AA954595 C75606 W80742 100491 34803.1 D56165 M36981 X58965 NM.002512 BE379177 AA314836 BE256445 BE252016 AW248343 AI720933 AW085701 BE386050 BE619742

BE277805 AA147951 AA603113 BE253293 AI246588 A1183405 AI954174 AI126891 AI829101 A1123832 A 129670 AA471268 A 170242 A 873079 AA148011 AI608620 AA482961 AI003658 H43261 AA657978 AI735072 R83138 AA722002AA626271 AW273877 BE464626 AA071483 AA429973 AA494342 AA620436 AA775597 AA775601 AA826847 AI192585 AA826359 AA411159 AH93419 AI204013 AA705323 AA716255 AI784611 AI081144 AI128227 AA828464 AI148911 AI493446 AI626084 AI189180 A1721196 AI190618 AA284987 AI128543 AA632064 AI333073 AI278470 AA131688 AI491768 AA937581 AA630065 AA834257 AW249841 AA583742 AI309756 AA961676 AI760860 AA557818 AA954238 H43655 AI302564 AA127545 AI609219 H20426 AI042292 AI056466 AA581836 W47002 AA422057 AA937673 F29757 AA829208 AW327462 AA372098 W02144 AA036805 AA487365 AA961037 Al 139946 AA487250 AA737118 AI952504 AI242293 AA650552 AI708401 AI633133 AA630848 AA654317 F24128 AI434165 W46252 AW043879 AI033763 F37228 AA687809 N49087 AA876981 AA506947 AI914572 AI833284 F22253 AA026222 R50166 AI219267 N27095 AA496512 A1784222 AI289904 AA513146 AA528547 AA418700 F36721 AI880700 AI601170 AJ862851 AI708633 AA524499 AA642220 AA496628 AI718709 W80579 AI720547 F20718 AA649943 AA588229 N40503 H46029 BE262669 BE391069 BE537538 AI510751 AI906968 AI318611 H46099 AI472604 T60667 AA373087 W32479 AA514034 BE619183 AA134672 AA127544 H26942 BE536689 AW327461. AA422139 AW262357 AW327348 F33510 AI630382 AW827126 F27133 AI335189 AW517599 W80471 AA885814 N89681 BE393173 AA617760 AA584268 AA460537 AA446261 H20425 N64040 AW276801 AA316367 AA071232 BE545409 AA308292 BE274447 AA380861 AA340038 AA341806 AA865579 AI018634 AI766314 AI919302 AA872367 AA991404 AI906961 AA888375 BE621012 AA505388 AA935192 AA290828 R50220 H50814 H44721 AW951723 AA514796 AA418708 AW673377 AA379622 AA977995 AA708224 AA708216 AI318249 AI318233 AA411160 AA026221 AA316774 AA486908 AI500094 AA096362 AW583742 BE536422 BE618653 R70203 AA131732 AA345048 BE562720 T28342

100518 13165.1 NM.004415 AL031058 M77830 BE149760 AW752599 AW848723 AW376697 AW376817 AW376699 AW848371 AW376782 AW848789 AW361413 AW849074AW997139 AW799304 AW7993098E077020 BE077017 BE185187 AW997196 BE156621 BE179915 BE006561 BE143155 AW890985 BE002107 AW103521 AA857316 AW383133 BE011378 AW170253 BE185750 AW886475 BE160433 J05211 BE082576 BE082584 BE004047 AW607238 AW377700 AW377699 BE082526 BE082505 BE082507 BE082514 AW178000 AW177933 AI905935 AW747877 AW748114 BE148516 AW265328 AW847678 AW847688 AW365151 AW365148 AW365153 AW365156 AW365175 AW365157 AW365154 AW068840 BE005272 AW365145 BE001925 BE182166 BE144243 BE001923 AI951766 AI434518 BE184920 BE184933 AI284090 BE184941 AW804674 BE184924 C04715 W39488 AW995615 BE184948 BE159646 AW606653 AA099891 AA131128 AA337270 AA340777 AW384371 AA852212 R58704 AW366566 AW364859 AA025851 AA025852 AA455100 AA719958 AW352220 AW996245 BE165351 BE073467 AA377127 AW890264 AW609750 AW391912 AW849690 T87267 AW853812 AA852213 W74149 BE009090 AA056401 H91011 AW368529 AW390272 C18467 AW674920 N57176AA026480AW576767 H93284AA026863AW177787AA026654AW177786 BE092134 BE092137BE092136AW177784 AI022862 BE091653 AW376811 AW848592 AA040018 BE185331 BE182164 AA368564 A 951576 T29918 AA131077 95048 W25458 AW205789 H90899 N29754 W32490 R20904 BE167181 BE167165 N84767 H27408 H30146 AH90590 C03378 A1554403 A1205263 AA128470

AI392926 AF139065 AW370813 AW370827 AW798417 AW798780 AW798883 AW798569 R33557 AA149190 C03029 AW177783 AA088866 AW370829 AA247685 BE002273 AI760816 AI439101 A 879451 A1700963 AA45 923 AI340326 AI590975 T48793 AI568096 Al 142882 AA039975 AI470146 AA946936 BE067737 BE067786 W19287 AA644381 AA702424 AI417612 AI306554 AI686869 AI568892 AW190555 AI571075 AI220573 AA056527 AI471874 AI304772 AW517828 AI915596 AI627383 AI270345 AW021347 AW166807 AW105614 AI346078 AA552300 W95070 AI494069 AI911702 AA149191 AA026864 AI830049 AI887258 AW780435 AI910434 AI819984 AI858282 AI078449 AI025932 AI860584 AI635878 AA026047 AA703232 D12062 AW192085 AA658154 AW514597 AW591892 T87181 AA782066 AW243815 AW150038 AW268383 AW004633 AI927207 AA782109 AW473233 AI804485 AW169216 AI572669 AA602182 AW015480 AW771865 AI270027 AA961816 AA283207 AI076962 AI498487 AI348053 AI783914 H44405 AW799118 AA128330 AA515500 AA918281 W02156 A1905927 AA022701 W38382 R20795 T77861 AW860878

100528 45979.1 BE386801 AU077299 AA143755 BE302747 AA853375 U30162 BE274163 BE277479 BE408180 BE274874 C15000 AA047476 N27099 AI359165

AI638794 AI151283 AI863925 AW444977 AI207392 AA931263 AA443112 R40138 AW068538 AA351008 AA676972 R62503 AA916492 AW001865 H42334 H38280 AA121497 AA114137 AI750938 M17783 AA383786 BE274462 AI753182 C05975 AA347404 AW069298 AI754351 AI754044 AA188808 AA186879 AA565243 AL040655 AA456177 AI750722 AA045756 AA213580 C16936 AW578747 AW753731 H41632 N44761 R58560 R61260 AA039902 N59721 AW992543 R68380 AA149686 T29017 H03739 BE383822 BE387105 BE408251 BE410425 H41560 AA247591 BE389677 AI752233 AI566195 AA868004 AI424523 AW753720 AA852159 BE386803

100559 2260.1 NM 000094 L02870 D13694 S51236 M96984 AW946290 M65158 AI285422 D29523 AL119886 AW630655 L06862 AI884355 AW168737 T29085

AW797005 AW801340 AI355504 AW079048 AW801337 AI690455 AI972063 AW268565 W68588 AA587326 AA883498 AI033523 AW510356 AW591998 H98463 AL043852 A1150055 AI566239 AI624803 AA844717 H40670 AA922334 AI864424 AW615094 AW451233 AI302203 F31221 AI872170 W68589 AA904478 AI917631 AW014208 AW450759 AA847625 AI284033 AA848176 AA598507

100576 .1 X00356 NM.001741 M26095 X03662 M12667 X02330 X02330 AA716058 AW296074 X04861 AI695720 AA719597 124357 genbank_N22401 N22401 101624 entrez_M55998M55998 101625 entrez_M57293M57293 135158 57963 1 AL037551 AI804716AW439811 AI569470 AA075299 AI738572 AI270388 AI816783 AW263026 AI633951 AI655285 AI990572 AI950425

AW241533 AA916883 AA576693 AA160156 AA613783 AW078884 AI888282 AI275241 AI133467 AA164921

Tables 2A-8C were previously filed on November 9, 2001 in USSN 60/339,245 (18501-004100US)

Table 2A shows 504 genes down-regulated in lung tumors relative to normal lung and chronically diseased lung. Chronically diseased lung samples represent chronic non- malignant lung diseases such as fibrosis, emphysema, and bronchitis. These genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression.

Pkey: Unique Eos probeset identifier number ExAccn: Exemplar Accession number, Genbank accession number UnigenelD: Unigene number Unigene Title: Unigene gene file R1: 90th percentile of Al for normal lung samples divided by the 80th percentile of Al for adenocarcinoma and squamous cell carcinoma lung tumor samples.

R2: median of Al for normal lung samples divided by 90th percentile of Al for adenocarcinoma and squamous cell carcinoma lung tumor samples. R3: median of Al for normal lung samples minus the 15th percentile of Al for all normal lung, chronically diseased lung and tumor samples divided by the 90th percentile of Al for adenocarcinoma and squamous cell carcinoma lung tumor samples minus the 15th percentile of Al for all normal lung, chronically diseased lung and tumor samples. average of Al for normal lung samples divided by average Al for squamous cell carcinoma and adenocarcinoma lung tumors. median of Al for normal lung samples divided by the 90th percentile of Al for adenocarcinomas. median of Al for normal lung samples minus the 15th percentile of Al for all normal lung, chronically diseased lung and tumor samples divided by the 90th percentile of Al for adenocarcinomas minus the 15th percentile of Al for all normal lung, chronically diseased lung and tumor samples.

R7: average of Al for normal lung samples divided by the 90th percentile of Al for squamous cell carcinomas. R8: median of Al for normal lung samples minus the 15th percentile of Al for all normal lung, chronically diseased lung and tumor samples divided by the 90th percentile of Al for squamous cell carcinomas minus the 15th percentile of Al for all normal lung, chronically diseased lung and tumor samples.

Pkey ExAccn UnigenelD Unigene Title R1 R2 R3 R4 R5 R6 R7 R8

100095 Z97171 Hs.78454 myocilin; trabecular meshwork inducible 40.20

100115 NM 002084 Hs.336920 glutathione peroxidase 3 (plasma) 3.46

100138 U83508 Hs.2463 angiopoietin 1 2.30

100299 D49493 Hs.2171 growth differentiation factor 10 11.0'

100306 U86749 Hs.80598 transcription elongation factor A (SH); 3.06

100447 NM 014767 Hs.74583 KIAA0275 gene product 3.16

100458 S74019 Hs.247979 Vpre-B 42.40

100862 AA005247 Hs.285754 Hepatocyte Growth Factor Receptor 4.13

100959 AA359129 Hs.118127 actin; alpha; cardiac muscle 125.60

101032 BE206854 Hs.46039 phosphoglycerate mutase 2 (muscle) 36.40

101081 AF047347 Hs.4880 amyloid beta (A4) precursor protein-bind 34.60

101088 X70697 Hs.553 solute carrier family 6 (neurotransmitte 193.20

101125 AJ250562 Hs.82749 transmembrane 4 superfamily member 2 3.10

101180 U11874 Hs.846 interleukin 8 receptor; beta 54.86

101308 L41390 "Homo sapiens core 2 beta-1 ,6-N-aoetylgl 33.20

101330 L43821 Hs.80261 enhancer of filamentation 1 (cas-likedo 36.40

101345 NM 005795 Hs.152175 Calcitonin receptor-like 2.29

101346 AI738616 Hs.77348 hydroxyprostaglaπdin dehydrogenase 15-(N 70.55

101397 M26380 Hs.180878 lipoprotein lipase 3.54

101414 NM 000066 Hs.38069 complement component 8; beta polypeptide 3.81

101435 NM.001100 Hs.1288 actin; alpha 1; skeletal muscle 34.60

101507 X16896 Hs.82112 interleukin 1 receptor; type I 37.60

101530 M29874 Hs.1360 cytochrome P450; subfamily IIB (phenobar 4.25

101537 AI469059 Hs.184915 zinc finger protein; Y-linked 2.54

101542 NM 00102 Hs.1363 cytochrome P450; subfamily XVII (steroid 5.50

101545 BE246154 Hs.154210 EDG1; endothelial differentiation, sphin 39.40

101554 BE207611 Hs.123078 thyroid stimulating hormone receptor 13.00

101560 AW958272 Hs.83733 Intercellular adhesion molecule 2, exon 3.38

101574 M34182 Hs.158029 protein kinase; cAMP-dependent; catalyti 4.37

101605 M37984 Hs.118845 troponin C; slow 3.80

101621 BE391804 Hs.62661 guanylate binding protein 1; interferon- 30.20

101680 AA299330 Hs.1042 Sjogren syndrome antigen A1 (52kD; ribon 2.75

101829 AW452398 Hs.129763 solute carrier family 8 (sodium/calcium 3.37

101842 M93221 Hs.75182 mannose receptor; C type 1 38.20

101961 AW004056 Hs.168357 "Hs-TBX2=T-box gene {T-box region} [huma 2.32

101994 T92248 Hs.2240 uteroglobin 6.85

102020 AU077315 Hs.154970 transcription factor CP2 2.45

102091 BE280901 Hs.83155 aldehyde dehydrogenase 7 6.75

102112 AW025430 Hs.155591 forkhead box F1 54.60

102190 AA723157 Hs.73769 folate receptor 1 (adult) 3.98

102202 NM 000507 Hs.574 fructose-bisphosphatase 1 3.62

102241 NM.007351 Hs.268107 Multimerin 2.32

102310 U33839 Accession not listed in Genbank 7.00

102397 U41898 "Human sodium cotransporter RKST1 mRNA, 29.40

102571 U60115 Hs.239069 "Homo sapiens skeletal muscle LIM-protei 3.75

102620 AA976427 Hs.121513 Human clone W2-6 mRNA from chromosome X 3.07

102636 U67092 "Human ataxia-telangiectasia locus prate 2.40

102667 U70867 Hs.83974 solute carrier family 21 (prostaglaπdiπ 3.15

102675 U72512 Hs.7771 "Human B-cell receptor associated protei 3.56

102698 M18667 Hs.1867 progastricsin (pepsinogen C) 4.51

102727 U79251 Hs.99902 opioid-binding protein/cell adhesion mol 12.00

102852 V00571 Hs.75294 corticotropin releasing hormone 37.40

103026 X54162 Hs.79386 thyroid and eye muscle autoantigen D1 (6 13.00

103028 X54380 Hs.74094 pregnancy-zone protein 28.80

103098 M86361 Human mRNA for T cell receptor; clone IG 10.00

103117 X63578 Hs.295449 parvalbumin 5.00

103241 X76223 H.sapiens MAL gene exon 4 2.47

103280 U84722 Hs.76206 Cadherin 5, VE-cadherin (vascular epithe 2.69

103360 Y16791 Hs.73082 keratin; hair; acidic; 5 2.16 103496 Y09267 Hs.132821 flavin containing monooxygenase 2 5.97

103508 Y10141 "H.sapiens DAT1 gene, partial, VNTR" 3.27

103561 NM 001843 I Hs.143434 contactin 1 2.40

103569 NM.005512 ! Hs.151641 glycoprotein A repetitions predominant 2.99

103575 Z26256 "H.sapiens isoform 1 gene for L-type cai 4.18

103627 Z48513 H.sapiens XG mRNA (clone PEP6) 3.44

103767 BE244667 Hs.296155 CGI-100 protein 2.25

103850 AA187101 Hs.213194 Hypothetical protein MGC10895; sim to SR 46.55

104078 AA402801 Hs.303276 ESTs 3.05

104326 AW732858 Hs.143067 ESTs 3.54

104352 BE219898 Hs.173135 dual-specificity tyrosine-(Y)-phosphoryl 3.16

104398 AI423930 Hs.36790 ESTs; Weakly similar to putative p150 [H 64.80

104473 AI904823 Hs.31297 ESTs 3.38

104493 AW960427 Hs.79059 ESTs; Moderately similar to TGF-BETA REC 2.47

104495 AW975687 Hs.292979 ESTs 28.60

104595 AI799603 Hs.271568 ESTs 3.42

104597 AI364504 Hs.93967 ESTs; Weakly similar to Slit-1 protein [ 6.00

104659 AW969769 Hs.105201 ESTs 34.00

104686 AA010539 Hs.18912 ESTs 11.00

104691 U29690 Hs.37744 ESTs; Beta-1 -adrenergic receptor 56.80

104764 AI039243 Hs.278585 ESTs 60.40

104776 AA026349 ESTs 34.20

104825 AA035613 Hs.141883 ESTs 3.03

104865 T79340 Hs.22575 Homo sapiens cDNA: FLJ21042 fis, clone C 41.20

104942 NM.016348 Hs.10235 ESTs 3.27

104989 R65998 Hs.285243 ESTs 40.00

105062 AW954355 Hs.36529 ESTs 3.20

105101 H63202 Hs.38163 ESTs 34.20

105173 U54617 Hs.8364 ESTs 4.17

105194 R06780 Hs.19800 ESTs 16.00

105226 R58958 Hs.26608 ESTs 2.34

105256 AA430650 Hs.16529 transmembrane 4 superfamily member (tetr 2.72

105394 BE245812 Hs.8941 ESTs 2.61

105647 Y09306 Hs.30148 homeodomain-interacting protein kinase 3 33.60

105789 AF106941 Hs.18142 arrestin; beta 2 3.59

105817 AA397825 synaptopodin 4.46

105847 AW964490 Hs.32241 ESTs 35.40

105894 AI904740 Hs.25691 calcitonin receptor-like receptor activi 3.43

105999 BE268786 Hs.21543 ESTs 7.00

106075 AA045290 Hs.25930 ESTs 42.60

106178 AL049935 Hs.301763 KIAA0554 protein 34.80

106381 AB040916 Hs.24106 ESTs 12.00

106467 AA450040 Hs.154162 ADP-ribosylation factor-like 2 3.69

106536 AA329648 Hs.23804 ESTs 96.40

106569 R20909 Hs.300741 sorcin 47.20

106605 AW772298 Hs.21103 Homo sapiens mRNA; cDNA DKFZp564B076 (fr 220.40

106842 AF124251 Hs.26054 novel SH2-containing protein 3 2.55

106844 AA485055 Hs.158213 sperm associated antigen 6 39.20

106870 AI983730 Hs.26530 serum deprivation response (phosphatidyl 2.28

106943 AW888222 Hs.9973 ESTs 4.28

106954 AF128847 Hs.204038 ESTs 4.32

107106 AA862496 Hs.28482 ESTs 10.45

107163 AF233588 Hs.27018 ESTs 2.57

107201 D20378 Hs.30731 EST 3.84

107238 D59362 Hs.330777 EST 8.00

107376 U90545 Hs.327179 solute carrier family 17 (sodium phospha 10.67

107530 Y13622 Hs.85087 latent transforming growth factor beta b 2.32

107688 AW082221 Hs.60536 ESTs 34.60

107706 AA015579 Hs.29276 ESTs 28.40

107723 AA015967 EST 3.29

107727 AA149707 Hs.173091 DKFZP434K151 protein 80.80

107750 AA017291 Hs.60781 ESTs 51.40

107751 AA017301 Hs.235390 ESTs 3.14

107873 AK000520 Hs.143811 ESTs 9.00

107899 BE019261 Hs.83869 ESTs; Weakly similar to !!!! ALU SUBFAMI 3.65

107994 AA036811 Hs.48469 ESTs 44.60

107997 AL049176 Hs.82223 Human DNA sequence from clone 141H5 on c 32.00

108041 AW204712 Hs.61957 ESTs 30.80

108048 AI797341 Hs.165195 ESTs 4.75

108338 AA070773 "zm53g11.s1 Stratagene fibroblast (#9372 2.33

108434 AA078899 "zm94b1.s1 Stratagene colon HT29 (#93722 2.92

108447 AA079126 "zm92a11.s1 Stratagene ovarian cancer (# 3.06

108480 AL133092 Hs.68055 ESTs 34.00

108499 AA083103 "zn1b12.s1 Stratagene hNT neuron (#93723 3.36

108535 R13949 Hs.226440 Homo sapiens clone 24881 mRNA sequence 19.00

108550 AA084867 "zn11f6.s1 Stratagene hNT neuron (#93723 12.00

108604 AA934589 Hs.49696 ESTs 2.33

108625 AW972330 Hs.283022 ESTs 5.82

108629 AA102425 "zn24c6.s1 Stratagene neuroepithelium NT 3.42

108655 AA099960 "zm65c6.s1 Stratagene fibroblast (#93721 7.00

108756 AA127221 Hs.117037 Homo sapiens mRNA; cDNA DKFZp564N1164 (f 6.05

108864 AI733852 Hs.199957 ESTs 28.80

108895 AL138272 Hs.62713 ESTs 32.80

108921 AI568801 Hs.71721 ESTs 57.80

108967 AA142989 Hs.71730 ESTs 28.80 109001 AI056548 Hs.72116 ESTs, Moderately similar to hedgehog-int 2.57

109003 AA147497 Hs.71825 ESTs 2.11

109004 AA156235 Hs.139077 EST 5.60

109065 AA161125 Hs.252739 EST 10.00

109250 H83784 Hs.62113 ESTs; Weakly similar to PHOSPHATIDYLETHA 3.44

109490 AA233416 Hs.139202 ESTs 2.92

109510 AI798863 Hs.87191 ESTs 2.40

109578 F02208 Hs.27214 ESTs 10.00

109601 F02695 Hs.311662 EST 40.80

109613 H47315 Hs.27519 ESTs 54.40

109650 R31770 Hs.23540 ESTs 31.20

109682 H18017 Hs.22869 ESTs 8.40

109724 D59899 Hs.127842 ESTs 29.40

109782 AB020644 Hs.14945 long fatty acyl-CoA synthetase 2 gene 3.00

109833 R79864 Hs.29889 ESTs 10.00

109837 H00656 Hs.29792 ESTs 6.49

109977 T64183 Hs.282982 ESTs 2.75

109984 AI796320 Hs.10299 ESTs 107.01

110146 H41324 Hs.31581 ESTs; Moderately similar to SYNTAXIN 1B 2.22

110271 H28985 Hs.31330 ESTs 3.48

110280 AW874263 Hs.32468 ESTs 44.20

110420 R93141 Hs.184261 ESTs 32.00

110578 T62507 Hs.11038 ESTs 28.40

110634 R98905 Hs.35992 ESTs 20.00

110726 AW961818 Hs.24379 potassium voltage-gated channel; shaker- 4.15

110837 H03109 Hs.108920 ESTs; Weakly similar to semaphorin F [H. 56.80

110875 N35070 Hs.26401 tumor necrosis factor (ligand) superfami 3.13

110894 R92356 Hs.66881 ESTs; Moderately similar to cytoplasmic 5.33

110971 AI760098 Hs.21411 ESTs 44.60

111023 AV655386 Hs.7645 ESTs 32.40

111057 T79639 Hs.14629 ESTs 17.14

111247 AW058350 Hs.16762 Homo sapiens mRNA; cDNA DKFZp564B2062 (f 4.58

111330 BE247767 Hs.18166 KIAA0870 protein 3.42

111374 BE250726 Hs.283724 ESTs; Moderately similar to HYA22 [H.sap 3.91

111442 AW449573 Hs.181003 ESTs 33.20

111737 H04607 Hs.9218 ESTs 53.00

111747 AI741471 Hs.23666 ESTs 46.20

111807 R33508 Hs.18827 ESTs 16.00

111862 R37472 Hs.21559 EST 3.91

112045 AI372588 Hs.8022 TU3A protein 2.74

112057 R43713 Hs.22945 EST 4.92

112214 AW148652 Hs.167398 ESTs 13.00

112263 R52393 Hs.25917 ESTs 2.43

112314 AW206093 Hs.748 ESTs 9.00

112324 R55965 Hs.26479 limbic system-associated membrane protei 14.00

112362 AW300887 Hs.26638 ESTs; Weakly similar to CD20 receptor [H 2.49

112380 H63010 Hs.5740 ESTs 2.34

112425 AA324998 Hs.321677 ESTs; Weakly similar to III! ALU SUBFAMI 8.00

112473 R65993 Hs.279798 pregnancy specific beta-1-glycoprotein 9 4.53

112492 N51620 Hs.28694 ESTs 29.80

112541 AF038392 Hs.116674 ESTs 3.62

112620 R80552 Hs.29040 ESTs 2.37

112623 AW373104 Hs.25094 ESTs 2.26

112867 T03254 Hs.167393 ESTs 12.00

112894 T08188 Hs.3770 ESTs 6.50

112954 AA928953 Hs.6655 ESTs 7.00

113029 AW081710 Hs.7369 ESTs; Weakly similar to till ALU SUBFAMI 4.39

113086 AA346839 Hs.209100 DKFZP434C171 protein 4.47

113140 T50405 Hs.175967 ESTs 10.00

113252 NM 004469 Hs.11392 c-fos induced growth factor (vascular en 14.00

113257 AI821378 Hs.159367 ESTs 3.72

113394 T81473 Hs.177894 ESTs 3.60

113437 T85349 Hs.15923 EST 35.00

113454 AI022166 Hs.16188 ESTs 6.00

113502 T89130 ESTs 39.60

113552 AI654223 Hs.16026 ESTs

113645 T95358 Hs.333181 ESTs 2.58

113691 T96935 Hs.17932 EST 38.20

113706 AA004693 Hs.269192 ESTs 3.09

113883 U89281 Hs.11958 oxidative 3 alpha hydroxysteraid dehydro 2.31

113924 BE178285 Hs.170056 Homo sapiens mRNA; cDNA DKFZp586B0220 (f 30.40

114035 W92798 Hs.269181 ESTs 13.00

114058 AK002016 Hs.114727 ESTs 5.00

114084 AA708035 Hs.12248 ESTs 40.60

114121 H05785 Hs.25425 ESTs 2.31

114124 W57554 Hs.125019 Human lymphoid nuclear protein (LAF-4) 7.00

114275 AW515443 Hs.306117 interleukin 13 receptor; alpha 1 6.00

114297 AA149707 Hs.173091 DKFZP434K151 protein 48.80

114427 AA017176 Hs.33532 ESTs; Highly similar to Miz-1 protein [H 3.45

114449 AA020736 "ze63b11.s1 Soares retina N2b4HR Homo sa 10.00

114452 AI369275 Hs.243010 ESTs, Moderately similar to RTCO.HUMAN G 14.00

114609 AA079505 "zm97a5.s1 Stratagene colon HT29 (#93722 3.13

114648 AA101056 "zn25b3.s1 Sfratagene neuroepifhelium NT 35.40

114731 BE094291 Hs.155651 Homo sapiens HNF-3beta mRNA for hepatocy 3.42

114762 AA146979 Hs.288464 ESTs 33.00 114776 AA151719 Hs.95834 ESTs 34.40

115009 AA251561 Hs.48689 ESTs 30.20

115272 AW015947 ESTs;' Weakly similar to hypothetical L1 32.60

115279 AW964897 Hs.290825 ESTs 6.00

115302 AL109719 Hs.47578 ESTs 12.00

115365 AW976252 Hs.268391 ESTs 3.32

115559 AL079707 Hs.207443 ESTs 48.00

115566 AI142336 Hs.43977 ESTs 56.20

115683 AF255910 Hs.54650 ESTs, Weakly similar to (defline not ava 31.40

115744 AA418538 Hs.43945 ESTs; Highly similar to dJ1178H5.3 [H.sa 33.60

115819 AA486620 Hs.41135 Endomucin 2 74.40

115949 AI478427 Hs.43125 ESTs 3.18

115965 AA001732 Hs.173233 ESTs 388.80

116035 AA621405 Hs.184664 ESTs 33.20

116049 AA454033 Hs.41644 ESTs 45.80

116081 AI190071 Hs.55278 ESTs 3.57

116082 AB029496 Hs.59729 ESTs 3.06

116213 AA292105 Hs.326740 leucine rich repeat (in FLU) interactin 50.60

116228 AI767947 Hs.50841 ESTs; Weakly similar to tuftelin [M.musc 3.85

116250 N76712 Hs.44829 ESTs 6.00

116419 AI613480 Hs.47152 ESTs; Weakly similar to testicular tekti 30.00

116617 D80761 Hs.45220 EST ^• 2.27

116784 AB007979 Hs.301281 teπascin R (restrictin; janusin) 47.20

116835 N39230 Hs.38218 ESTs 41.20

116970 AB023179 Hs.9059 KIAA0962 protein 11.00

117023 AW070211 Hs.102415 ESTs 91.00

117027 AW085208 Hs.130093 ESTs 49.40

117036 H88908 Hs.41192 EST 32.60

117110 AA160079 Hs.172932 ESTs 8.67

117209 W03011 Hs.306881 ESTs 30.60

117325 N23599 Hs.43396 ESTs 9.29

117454 N29569 Hs.44055 ESTs 3.19

117475 N30205 Hs.93740 ESTs 44.00

117543 BE219453 Hs.42722 ESTs 16.00

117567 AW444761 Hs.44565 ESTs 12.00

117570 N48649 Hs.44583 ESTs 11.00

117600 N34963 Hs.44676 EST 3.74

117730 N45513 Hs.46608 ESTs 6.00

117791 N48325 Hs.93956 EST 9.00

117929 N51075 Hs.47191 ESTs 29.20

117990 AA446167 Hs.47385 ESTs 8.00

118224 N62275 Hs.48503 EST 31.40

118244 N62516 Hs.48556 ESTs 32.80

118357 AL109667 Hs.124154 Homo sapiens mRNA full length insert cDN 2.40

118446 N66361 Hs.269121 ESTs 2.28

118447 N66399 Hs.49193 EST 30.80

118530 N67900 Hs.118446 ESTs 3.10

118549 N68163 Hs.322954 EST 3.41

118823 W03754 Hs.50813 ESTs; Weakly similar to long chain fatty 3.94

118862 W17065 Hs.54522 ESTs 3.58

118935 AI979247 Hs.247043 KIAA0525 protein 33.00

118944 AI734233 Hs.226142 ESTs; Weakly similar to III! ALU SUBFAMI 11.43

118995 N94591 Hs.323056 ESTs 14.00

119073 BE245360 Hs.279477 ERG-2/ERG-1; V-ets avian erythroblastosi 52.60

119268 T16335 Hs.65325 EST 31.40

119514 W37937 Accession not listed in Genbank 3.50

119824 W74536 Hs.184 advanced glycosylation end product-speci 2.75

119831 AL117664 Hs.58419 DKFZP586L2024 protein 3.21

119861 W78816 Hs.49943 ESTs; Moderately similar to III! ALU SUB 33.80

119889 W84346 Hs.58671 ESTs 30.03

119921 W86192 Hs.58815 ESTs 29.00

120082 H80286 Hs.40111 ESTs

120094 AA811339 Hs.124049 ESTs 6.00

120132 W57554 Hs.125019 Human lymphoid nuclear protein (LAF-4) 36.60

120378 AA223249 Hs.285728 ESTs 12.00

120404 AB023230- Hs.96427 KIAA1013 protein 39.40

120504 AA256837 ESTs 8.00

120512 N55761 Hs.194718 ESTs 33.00

120667 AA287740 Hs.78335 microtubule-associated protein; RP/EB fa 4.18

120777 AA287702 Hs.10031 KIAA0955 protein 46.60

121082 AA398722 ESTs 39.00

121191 AA400205 Hs.104447 ESTs 41.60

121248 AA400914 Hs.97827 EST

121363 AI287280 Hs.97933 ESTs 12.00

121366 AI743515 ESTs 20.00

121483 AI660332 Hs.25274 ESTs; Moderately similar to putative sev 3.32

121518 AA412155 ESTs 30.20

121545 AA412442 Hs.98132 ESTs 2.29

121622 AA416931 Hs.126065 ESTs 9.00

121665 AA416556 Hs.98234 ESTs 34.80

121709 AI338247 Hs.98314 Homo sapiens mRNA; cDNA DKFZp586L0120 (f 34.80

121730 AI140683 Hs.98328 ESTs 38.80

121740 AA421138 Hs.98334 EST 7.00

121772 AI590770 HS.110347 Homo sapiens mRNA for alpha integrin bin 36.20

121821 AL040235 Hs.3346 ESTs 3.61 121835 AB033030 Hs.300670 ESTs 2.34

121841 AA427794 Hs.104864 ESTs 2.61

121885 AA934883 Hs.98467 ESTs 2.25

121888 AA426429 Hs.98463 ESTs 2.92

121938 AA428659 Hs.98610 ESTs 46.80

121950 AA429515 EST 31.40

122030 AA431310 Hs.98724 ESTs 34.40

122054 AA431725 Hs.98746 EST 3.58

122211 AA300900 Hs.98849 ESTs; Moderately similar to bithoraxoid- 49.40

122233 AA436455 Hs.98872 EST 29.80

122247 AA436676 Hs.98890 EST 39.80

122253 AA436703 Hs.104936 ESTs; Weakly similar to hypothetical pro 9.00

122266 AA436840 Hs.98907 EST 3.60

122285 AA436981 Hs.121602 EST 3.14

122409 AA446830 Hs.99081 ESTs 30.80

122485 AA524547 Hs.160318 phospholem an 2.65

122697 AA420683 Hs.98321 Homo sapiens cDNA FLJ 14103 fis, clone MA 15.00

122772 AW117452 Hs.99489 ESTs 6.67

122831 AI857570 Hs.5120 ESTs 3.37

122913 AI638774 Hs.105328 ESTs 32.20

123049 BE047680 Hs.211869 ESTs 41.80

123076 AI345569 Hs.190046 ESTs 35.80

123136 AW451999 Hs.194024 ESTs

123309 N52937 Hs.102679 ESTs 19.00

123455 AA353113 Hs.112497 ESTs 82.80

123691 AA609579 Hs.112724 ESTs 3.95

123756 AA609971 Hs.112795 EST 35.40

123802 AA620448 Homo sapiens clone 24760 mRNA sequence 58.00

123837 AI807243 Hs.112893 ESTs 32.40

123844 AA938905 Hs.120017 olfactory receptor; family 7; subfamily 2.63

123936 NM 004673 Hs.241519 ESTs 29.00

123987 C21171 Hs.95497 ESTs; Weakly similar to GLUCOSE TRANSPOR 70.60

124013 AI521936 Hs.107149 ESTs; Weakly similar to PTB-ASSOCIATED S 28.40

124160 R40290 Hs.124685 ESTs 13.00

124205 H77570 Hs.108135 ESTs 4.74

124226 AA618527 Hs.190266 ESTs 2.35

124246 H67680 Hs.270962 ESTs 29.40

124348 AI796320 Hs.10299 ESTs 17.00

124358 AW070211 Hs.102415 "yw36g11.s1 Morton Fetal Cochlea Homo sa 3.07

124409 AI814166 Hs.107197 ESTs 3.14

124442 AW663632 Hs.285625 TATA box binding protein (TBP)-associate 2.48

124468 N51413 Hs.109284 ESTs 30.80

124479 AB011130 Hs.127436 calcium channel; voltage-dependent; alph 6.03

124519 A1670056 Hs.137274 ESTs; Weakly similar to SPLICEOSOME ASSO 2.50

124711 NM.004657 Hs.26530 serum deprivation response (phosphatidyl 59.20

124866 AI768289 Hs.304389 ESTs 8.00

124874 BE550182 Hs.127826 ESTs 37.60

125097 AW576389 Hs.335774 ESTs 10.00

125179 AW206468 Hs.103118 ESTs 3.12

125200 AW836591 Hs.103156 ESTs 2.79

125299 T32982 Hs.102720 ESTs 34.20

125400 AL110151 Hs.128797 DKFZP586D0824 protein 29.00

125810 H00083 aryl hydrocarbon receptor-interacting pr 32.20

126176 BE242256 Hs.2441 K1AA0022 gene product 12.00

126303 D78841 HUM525A05B Human placenta polyA+ (TFuji 33.60

126403 AW629054 Hs.125976 ESTs; Weakly similar to metalloprotease/ 35.80

126507 AL040137 Hs.23964 ESTs; Weakly similar to HC1 ORF [M.muscu 29.80

126773 AA648284 Hs.187584 ESTs 39.60

127307 AW962712 Hs.126712 ESTs; Weakly similar to plL2 hypothetica 28.80

127462 AA760776 Hs.293977 aa59b04.s1 NCI CGAP GCB1 Homo sapiens c 34.40

127486 AW002846 Hs.105468 ESTs 9.00

127572 AA594027 Hs.191788 ESTs 2.36

127609 X80031 Hs.530 ESTs 29.40

127832 AW976035 Hs.292396 ESTs 37.20

127898 AA774725 Hs.128970 ESTs 4.42

128073 AW340720 Hs.125983 ESTs 38.40

128101 AA905730 Hs.128254 ESTs 7.33

128149 NM 012214 Hs.177576 mannosyl (alpha-1;3-)-glycoprotein beta- 2.58

128212 W27411 Hs.336920 glutathione peroxidase 3 (plasma) 3.09

128333 W68800 Hs.12126 ESTs; Weakly similar to LR8 [H.sapiens] 34.40

128364 N76462 Hs.269152 ESTs; Weakly similar to ZINC FINGER PROT 10.00

128426 AI265784 Hs.145197 ESTs 4.31

128598 AA305407 Hs.102308 potassium inwardly-rectifying channel; s 31.20

128634 AA464918 ESTs; Moderately similar to HI! ALU SUB 41.60

128687 AW271273 Hs.23767 ESTs 87.00

128726 AI311238 Hs.104476 ESTs 4.02

128773 NM 004131 Hs.1051 granzyme B (granzyme 2; cytotoxic T-lymp 9.00

128833 W26667 Hs.184581 ESTs 3.76

128870 H39537 Hs.75309 eukaryotic translation elongation factor 2.66

128878 R25513 Hs.10683 ESTs 3.10

128885 AF134803 Hs.180141 cofilin 2 (muscle) 11.00

128998 W04245 Hs.107761 ESTs; Weakly similar to PUTATIVE RHO/RAC 3.21

129000 AA744902 Hs.107767 ESTs; Moderately similar to CaM-KII inhi 3.68

129038 AW156903 Hs.108124 ribosomal protein L41 3.17

129098 AW580945 Hs.330466 ESTs 34.60 129210 AL039940 Hs 202949 KIAA1102 protein 409

129240 AA361258 Hs 237868 interleukin 7 receptor 2 29

129262 BE222198 Hs 109843 ESTs 330

129301 AF182277 Hs 330780 Human cytochrome P450-IIB (hllB3) mRNA, 405

129331 AW167668 Hs 279772 ESTs, Highly similar to CGI-38 protein [ 409

129381 AW245805 Hs 110903 claudiπ 5 (transmembrane protein deleted 293

129565 X77777 Hs 198726 vasoaclive intestinal peptide receptor 1 16080

129595 U09550 Hs 1154 oviductal glycoprotem 1, 120kD 1000

129613 AW978517 Hs 172847 ESTs, Weakly similar to collagen alpha 1 340

129782 AW016932 Hs 104105 EST 900

129950 F07783 Hs 1369 decay accelerating factor for complement 8780

129958 R27496 Hs 1378 annexin A3 4 60

129959 AL036554 Hs 274463 defensm, alpha 1, myeloid related seque 272

130160 AA305688 Hs 267695 UDP-Gal betaGlcNAc beta 1,3 galactosyltr 4220

130259 NM.000328 Hs 153614 redπitis pigmentosa GTPase regulator 254

130273 AW972422 Hs 153863 MAD (mothers against deoapentaplegic Dr 51 60

130312 AF056195 Hs 15430 DKFZP586G1219 protein 3 16

130436 NM 001928 Hs 155597 D ∞mponentof complement (adipsin) 411

130523 AA999702 Hs 214507 ESTs 477

130799 AB028945 Hs 12696 ESTs 600

130885 NM 005883 Hs 20912 adeno atous polyposis coli like 354

131002 AL050295 Hs 22039 KIAA0758 protein 350

131012 AL039940 Hs 202949 KIAA1102 protein 2000

131031 NM 001650 Hs 288650 aquaponn 4 41 20

131061 N64328 Hs 268744 ESTs, Moderately similar to KIAA0273 [H 31 40

131066 AW169287 Hs 22588 ESTs 2960

131082 AI091121 Hs 246218 ESTs, Weakly similar to zinc finger prot 900

131087 AF147709 Hs 22824 ESTs, Weakly similar to p160 myb-binding

131161 AF033382 Hs 23735 potassium voltage gated channel, subfami 3 14

131179 AA171388 Hs 184482 DKFZP586D0624 protein 380

131182 AI824144 Hs 23912 ESTs 367

131205 NM.003102 Hs 2420 superoxide dismutase 3, extracellular 298

131277 AA131466 Hs 23767 ESTs 3 15

131281 AA251716 Hs 25227 ESTs 3220

131282 X03350 Hs 4 alcohol dehydrogenase 3 (class I), gamma 344

131285 AI567943 Hs 25274 ESTs, Moderately similar to putative sev 640

131355 R52804 Hs 25956 DKFZP564D206 protein 800

131391 AW085781 Hs 26270 ESTs 1000

131461 AA992841 Hs 27263 butyrate response factor 2 (EGF-response 2880

131487 F13036 Hs 27373 Homo sapiens mRNA, cDNA DKFZp56401763 (f 403

131517 AB037789 Hs 263395 ESTs, Highly similar to semaphoπn Via [ 3900

131545 AL137432 Hs 28564 ESTs 11 00

131583 AK000383 Hs 323092 ESTs Weakly similar to dual specificity 1000

131647 AA359615 Hs 30089 ESTs 247

131675 H15205 Hs 30509 ESTs 306

131676 AI126821 Hs 30514 ESTs 4580

131708 S60415 Hs 30941 calcium channel, voltage-dependent, beta 228

131717 X94630 Hs 3107 CD97 antigen 3 78

131756 AA443966 Hs 31595 ESTs 4060

131762 AA744902 Hs 107767 ESTs, Moderately similar to CaM Kll inhi 3 67

131821 AA017247 Hs 164577 ESTs 287

131839 AB014533 Hs 33010 KIAA0633 protein 3 48

131861 AL096858 Hs 184245 KIAA0929 protein Msx2 interacting nuclea 5400

132015 AI418006 Hs 3731 ESTs 49 20

132070 BE622641 Hs 38489 ESTs 3480

132242 AA332697 Hs 42721 ESTs 2 68

132334 AW080704 Hs 45033 lacπmal proline rich protein 466

132476 AL119844 Hs 49476 Homo sapiens clone TUA8 Cn-du chat regi 3420

132490 NM 001290 Hs 4980 LIM binding domain 2 266

132533 AI922988 Hs 172510 ESTs 1300

132598 X80031 Hs 530 collagen, type IV, alpha 3 (Goodpasture 3060

132619 H28855 Hs 53447 ESTs, Moderately similar to kinesm ligh 402

132652 N41739 Hs 61260 ESTs 3 18

132726 N52298 Hs 55608 ESTs, Weakly similar to cDNA EST yk484g1 11 43

133028 R51604 Hs 300842 ESTs 237

133071 BE384932 Hs 64313 ESTs 227

133120 NM 003278 Hs 65424 tetranecbn (plasminogen binding protein 263

133129 AA428580 Hs 65551 ESTs 549

133147 AA026533 Hs 66 interleukin 1 receptor-like 1 620

133151 NM 014051 Hs 94896 ESTs 369

133213 AA903424 Hs 6786 ESTs 31 40

133276 AW978439 Hs 69504 ESTs 900

133377 AJ131245 Hs 7239 SEC24 (S cerevisiae) related gene famil 41 20

133407 AF017987 Hs 7306 secreted frizzled related protein 1 5020

133535 AL134030 Hs 284180 protocadheπn 2 (cadhenn like 2) 372

133537 U41518 Hs 74602 aquaponn 1 (channel forming integral pr 3 35

133656 BE149455 Hs 75415 Accession not listed in Genbank 265

133689 NM.001872 Hs 75572 carboxypeptidase B2 (plasma) 9080

133779 T58486 Hs 222566 ESTs 305

133978 AF035718 Hs 78061 transcription factor 21 292

133985 L34657 Hs 78146 platelet/endothelial cell adhesion molec 345

134000 AW175787 Hs 334841 selenium binding protein 1 405

134111 AI372588 Hs 8022 TU3A protein 449

134185 AA285136 Hs 301914 Homo sapiens mRNA, cDNA DKFZp586K1220 (f 327

134204 AI873257 Hs 7994 ESTs, Weakly similar to CGI 69 protein [ 4080 134641 AI092634 Hs 156114 protein tyrosine phosphatase, non recept 376

134677 AA251363 Hs 177711 ESTs 3220

134745 NM 000685 Hs 89472 angiotensin receptor 1B 1500

134749 T28499 Hs 89485 carbonic anhydrase IV 305

134786 T29618 Hs 89640 angiopoietm 1 receptor, TEK tyrosine ki 5780

134825 U33749 Hs 197764 thyroid transcription factor 1 373

134978 AI829008 Hs 333383 ficolin (collagen/fibπnogen domam-cont 252

135010 N50465 Hs 92927 ESTs 31 60

135053 AW796190 Hs 93678 ESTs 321

135081 AF069517 Hs 173993 RNA binding motif protein 6 2880

135091 AA493650 Hs 94367 ESTs 424

135135 AA775910 Hs 95011 syntrophin, beta 1 (dystrophm associate J 00

135203 C15737 Hs 269386 ESTs 431

135236 AI636208 Hs 96901 ESTs 4300

135266 R41179 Hs 97393 Human mRNA for KIAA0328 gene, partial cd 642

135346 NM.000928 Hs 992 phospholipase A2, group IB (pancreas) 382

135378 AW961818 Hs 24379 potassium voltage-gated channel, shaker- 4 15

135387 NM 001972 Hs 99863 elastase 2, neutrophil 3720

135388 W27965 Hs 99865 EST 3880

135402 L12398 Hs 99922 dopamine receptor D4 421

TABLE 2B shows the accession numbers for those pnmekeys lacking unigenelD's for Table 2A For each probeset we have listed the gene cluster number from which the oligonucleotides were designed Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California) The Genbank accession numbers for sequences comprising each cluster are listed in the "Accession" column

Pkey Unique Eos probeset identifier number

CAT number Gene cluster number Accession Genbank accession numbers

Pkey CAT number Accessions

108447 43452.-7 AA079126 108550 120073 1 AA084867AA084996 108655 127522.1 AA099960 AA113013 102397 44371.-1 U41898 126303 1525933.1 D78841 D78880 125810 1554054.1 H00083 R81062 103627 2615.2 Z48513 Z48512 121366 280401 1 AI743515 AA405617 AW276706 114609 116777 1 AA079505AA079537 115272 172113 1 AW015947AA211890AA279425 108338 112186 1 AA070773AA070774 108434 114012.1 AA078899AA078782AA075788 123802 genbank_AA620448 AA620448 102310 NOT_FOUND_entrez_U33839 U33839 102636 entrez_U67092 U67092 104776 genbaπk_AA026349 AA026349 120504 genbank AA256837 AA256837 113502 genbank T89130T89130 108499 genbank_AA083103 AA083103 101308 entrez_L41390 L41390 108629 genbank_AA102425 AA102425 103098 221.215 M86361 Z26593 X02850 D13070 AE000659 M17649 M87869 M87871 X61077 M16286 AF018169 X61079 S59351 X60142 AF043169 103241 entrez_X76223 X76223 103508 entrez_Y10141 Y10141 103575 entrez_Z26256 Z26256 119514 NOT_FOUND_entrez_W37937 W37937 121082 genbank AA398722 AA398722 128634 AA464918_at AA464918 105817 genbank_AA397825 AA397825 121518 genbank_AA412155 AA412155 114449 genbank_AA020736 AA020736 114648 genbank_AA101056 AA101056 121950 genbank_AA429515 AA429515 107723 genbank_AA015967 AA015967

Table 3A shows 452 genes up-regulated in chronically diseased lung relative to normal lung. Chronically diseased lung samples represent chronic non-malignant lung diseases such as fibrosis, emphysema, and bronchitis. These genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression.

Pkey: Unique Eos probeset identifier number

ExAccn: Exemplar Accession number, Genbank accession number

UnigenelD: Unigene number

Unigene Title: Unigene gene title

R1: 80th percentile of Al for chronically diseased lung samples divided by the 90th percentile of Al for normal lung samples.

R2: 80th percentile of Al for chronically diseased lung samples divided by the 90th percentile of normal lung samples, squamous cell carcinomas and adenocarcinomas R3: 70th percentile of Al for chronically diseased lung samples minus the 15th percentile of Al for all normal lung, chronically diseased lung and tumor samples divided by the 90th percentile of normal lung samples, squamous cell carcinomas and adenocarcinomas minus the 15th percentile of Al for all normal lung, chronically diseased lung and tumor samples

Pkey ExAccn UnigenelD Unigene Title R1 R2 R3

135423 U50531 Hs.138751 Human BRCA2 region, mRNA sequence CG030 12.40

135378 AW961818 Hs.24379 MUM2 protein 2.13

135346 NM.000928 Hs.992 phospholipase A2, group IB (pancreas)

135235 AW298244 Hs.293507 ESTs 12.40

135057 U90268 Hs.93810 cerebral cavernous malformations 1 11.67

134951 BE305081 Hs.169358 hypothetical protein 8.00

134799 M36821 Hs.89690 GR03 oπcogene 8.20

134786 T29618 Hs.89640 TEK tyrosine kinase, endothelial (venous

134772 NM 000829 Hs.163697 glutamate receptor, ioπotrophic, AMPA 4 29.80

134752 BE246762 Hs.89499 arachidoπate 5-lipoxygenase 1.93

134749 T28499 Hs.89485 carbonic anhydrase IV 2.07

134696 BE326276 Hs.8861 ESTs

134636 NMJ05582 Hs.87205 lymphocyte antigen 64 (mouse) homolog, r 13.60

134627 AI018768 Hs.12482 glyceronephosphate O-acyltransferase 1.92

134622 AW975159 Hs.293097 ESTs, Weakly similar to A55380 faciogeni 1.92

134570 U66615 Hs.172280 SWI/SNF related, matrix associated, acti 13.20

134561 U76421 Hs.85302 adenosine deaminase, RNA-specific, B1 (h 1.78

134468 NM.001772 Hs.83731 CD33 antigen (gp67) 6.20

134417 NM 006416 Hs.82921 solute carrier family 35 (CMP-sialic aci

134343 D50683 Hs.82028 transforming growth factor, beta recepto

134323 BE170651 Hs.8700 deleted in liver cancer 1

134300 NM.001430 Hs.8136 endothelial PAS domain protein 1

134299 AW580939 Hs.97199 complement component C1 q receptor

134253 X52075 Hs.80738 sialophorin (gpL115, leukosialin, CD43) 20.60

134182 D52059 Hs.7972 KIAA0871 protein 12.20

133985 L34657 Hs.78146 platelet/endothelial cell adhesion molec

133978 AF035718 Hs.78061 transcription factor 21

133835 AI677897 Hs.76640 RGC32 protein

133651 AI301740 Hs.173381 dihydropyrimidinase-like 2

133633 D21262 Hs.75337 nucleolar and coiled-body phosphprotein 15.20

133565 AW955776 Hs.313500 ESTs, Moderately similar to ALU7.HUMAN A

133548 AW946384 Hs.178112 DNA segment, single copy probe LNS-CAI/L 1.77

133488 AA335295 Hs.74120 adipose specific 2

133478 X83703 Hs.31432 cardiac ankyrin repeat protein 2.08

133337 AF085983 Hs.293676 ESTs 9.60

133200 AB037715 Hs.183639 hypothetical protein FLJ10210 1.77

133153 AF070592 Hs.66170 HSKM-B protein 30.60

133130 AI128606 Hs.6557 zinc finger protein 161 22.60

133120 NM 003278 Hs.65424 tetranectin (plasminogen-binding protein

132928 AW168082 Hs.169449 protein kinase C, alpha 13.80

132836 AB023177 Hs.29900 KIAA0960 protein

132799 W73311 Hs.169407 SAC2 (suppressor of actin mutations 2, 41.60

132742 AA025480 Hs.292812 ESTs, Weakly similar to T33468 hypotheti 40.40

132548 X12830 Hs.193400 interleukin 6 receptor 7.20

132476 AL119844 Hs.49476 Homo sapiens clone TUA8 Cri-du-chat regi 4.76

132439 AK001942 Hs.4863 hypothetical protein DKFZp566A1524 1.88

132240 AB018324 Hs.42676 KIAA0781 protein 21.20

132210 NM.007203 Hs.42322 A kinase (PRKA) anchor protein 2 1.99

132199 AL041299 Hs.165084 ESTs 15.20

131751 T96555 Hs.31562 ESTs 1.76

131745 A1828559 Hs.31447 ESTs, Moderately similar to A46010 X-li 27.80

131694 NM 000246 Hs.3076 MHC class II transactivator 4.00

131686 NM.012296 Hs.30687 GRB2-associated binding protein 2

131676 AI126821 Hs.30514 ESTs 6.20

131629 Z45794 Hs.238809 ESTs 21.40

131589 C18825 Hs.29191 epithelial membrane protein 2

131536 AA019201 Hs.269210 ESTs 9.40

131517 AB037789 Hs.263395 sema domain, transmembrane domain (TM), 3.59

131355 R52804 Hs.25956 DKFZP564D206 protein 4.48

131253 R71802 Hs.24853 ESTs 15.00

131207 AF104266 Hs.24212 latrophilin 1.75

131156 AI472209 Hs.323117 ESTs 1.84

131066 AW169287 Hs.22588 ESTs 3.54

131061 N64328 Hs.268744 KIAA1796 protein

131053 AA348541 Hs.296261 guaniήe nucleotide binding protein (G pr 1.93

130895 AA641767 Hs.21015 hypothetical protein DKFZp564L0864 simil 16.60

130762 D84371 Hs.1898 paraoxonase 1 12.00 130657 AW337575 Hs.201591 ESTs

130655 AI831962 Hs.17409 cysteine-rich protein 1 (intestinal)

130589 AL110226 Hs.16441 DKFZP434H204 protein 2.08

130562 D50402 Hs.182611 solute earner family 11 (proton-coupled 1.91

130555 R69743 Hs.116774 integrin, alpha 1 9.60

130365 W56119 Hs.155103 eukaryotic translation initiation factor 11.60

130273 AW972422 Hs.153863 MAD (mothers against decapeπtaplegic, Dr 6.60

130259 NM.000328 Hs.153614 retinifis pigmentosa GTPase regulator 1.91

130090 H97878 Hs.132390 zinc finger protein 36 (KOX 18) 21.20

129958 R27496 Hs.1378 annexin A3 5.05

129898 AI672731 Hs.13256 ESTs

129875 AA181018 Hs.13056 hypothetical protein FLJ13920 18.60

129699 AB007899 Hs.12017 homolog of yeast ubiquitin-protein ligas

129626 F13272 Hs.111334 ferritin, light polypeptide

129598 N30436 Hs.11556 Homo sapiens cDNA FLJ12566 fis, clone NT 22.63

129593 AI338247 Hs.98314 Homo sapiens mRNA; cDNA DKFZp586L0120 (f

129565 X77777 Hs.198726 vasoactive intestinal peptide receptor 1 2.53

129527 AA769221 Hs.270847 delta-tubulin 39.20

129402 W72062 Hs.11112 ESTs 2.11

129385 AA172106 Hs.110950 Rag C protein 15.20

129315 NM 014563 Hs.174038 spondyloepiphyseal dysplasia, late 12.40

129312 T97579 Hs.110334 ESTs, Weakly similar to I78885 serine/th 20.83

129240 AA361258 Hs.237868 interleukin 7 receptor 1.95

129210 AL039940 Hs.202949 KIAA1102 protein

129122 AW958473 Hs.301957 nudix (nucleoside diphosphate linked oi 4.20

129057 N90866 Hs.276770 CDW52 antigen (CAMPATH-1 antigen)

128946 Y13153 Hs.107318 kynurenine 3-monooxygenase (kynurenine 3 5.20

128798 AF015525 Hs.302043 chemokine (C-C motif) receptor-like 2

128789 AW368576 Hs.139851 caveolin 2 2.24

128778 AA504776 Hs.186709 ESTs, Weakly similar to I38022 hypothet 12.20

128766 AW160432 Hs.296460 craniofacial development protein 1 26.40

128631 R44238 Hs.155546 KIAA1080 protein; Golgi-associated, gamm 1.78

128624 BE154765 Hs.102647 ESTs, Weakly similar to TRHY.HUMAN TRICH 2.51

128609 NM 003616 Hs.102456 survival of motor neuron protein interac 16.00

128603 NM.004915 Hs.10237 ATP-binding cassette, sub-family G (WHIT 12.80

128598 AA305407 Hs.102308 potassium inwardly-rectifying channel, s 4.00

128458 H55864 Hs.56340 ESTs

128061 AF150882 Hs.186877 sodium channel, voltage-gated, type XII, 17.20

127968 AA830201 Hs.124347 ESTs 21.30

127959 AI302471 Hs.124292 Homo sapiens cDNA: FLJ23123 fis, clone L

127944 AI557081 Hs.262476 S-adenosylmethionine decarboxylase 1 10.60

127925 AA805151 Hs.3628 mitogeπ-activated protein kinase kinase 13.40

127896 AI669586 Hs.222194 ESTs 7.00

127859 AA761802 Hs.291559 ESTs 14.00

127817 AA836641 Hs.163085 ESTs 14.00

127742 AW293496 Hs.180138 ESTs 11.00

127628 AI240102 Hs.322430 NDRG family, member 4 11.10

127609 X80031 Hs.530 collagen, type IV, alpha 3 (Goodpasture

127582 AA908954 Hs.130844 ESTs 19.60

127543 AK000787 Hs.157392 Homo sapiens cDNA FLJ20780 fis, clone CO 15.40

127535 AA568424 Hs.164450 ESTs 17.50

127404 AI379920 Hs.270224 ESTs 14.60

127396 L31968 Hs.187991 DKFZP564A122 protein 15.40

127374 AA442797 Hs.312110 ESTs, Weakly similar to I38022 hypothet 14.60

127346 AA203616 Hs.44896 DnaJ (Hsp40) homolog, subfamily B, membe 21.00

127340 BE047653 Hs.119183 ESTs, Weakly similar to ZN91 HUMAN ZINC 15.80

127307 AW962712 Hs.126712 ESTs, Weakly similar to AF191020 1 E2IG5

127242 AW390395 Hs.181301 cathepsin S 22.60

127167 AA625690 Hs.190272 ESTs 21.40

127046 AA321948 Hs.293968 ESTs 41.20

126928 AA480902 Hs.137401 ESTs 11.00

126900 AF137386 Hs.12701 plasmolipin 1.78

126852 AA399961 gb:zu68c01.r1 SoaresJestis.NHT Homo sap 5.60

126816 AA248234 gb:csg2228.seq.F Human fetal heart, Lamb 12.20

126812 AB037860 Hs.173933 nuclear factor l/A 17.19

126666 AA648886 Hs.151999 ESTs 13.57

126645 AA316181 Hs.61635 six transmembrane epithelial antigen of 15.40

126592 AI611153 Hs.6093 Homo sapiens cDNA: FLJ22783 fis, clone K 4.67

126556 AF255303 Hs.112227 membrane-associated nucleic acid binding 18.00

126433 AA325606 gb:EST28707 Cerebellum II Homo sapiens c 16.77

126299 AW979155 Hs.298275 amino acid transporter 2 14.60

126218 AL049801 Hs.13649 Novel human gene mapping to chomosome 13 3.50

126182 AA721331 Hs.293771 ESTs 13.40

126177 AW752782 Hs.129750 hypothetical protein FLJ 10546 18.20

126142 H86261 Hs.40568 ESTs 14.00

126077 M78772 Hs.210836 ESTs 16.59

125994 AI990529 Hs.270799 ESTs 17.40

125934 AA193325 Hs.32646 hypothetical protein FLJ21901 13.00

125847 AW161885 Hs.249034 ESTs 49.57

125831 H04043 gb:yj45c03.r1 Soares placenta Nb2HP Homo

125731 R61771 Hs.26912 ESTs 13.20

125676 BE612918 Hs.151973 hypothetical protein FLJ23511 11.20

125561 F18572 Hs.22978 ESTs, Weakly similar to ALU4.HUMAN ALU S

125552 H09701 Hs.278366 ESTs, Weakly similar to 138022 hypotheti 12.60

125489 H49193 Hs.124984 ESTs, Moderately similar to ALU7.HUMAN A 33.40 125422 AA903229 Hs.153717 ESTs 1.80

125331 AI422996 Hs.161378 ESTs 38.00

125309 T12411 Hs.183745 hypothetical protein FLJ 13456 18.20

125167 AL137540 Hs.102541 netrin 4 1.95

125139 AW194933 Hs.9788 hypothetical protein MGC10924 similar to 1.84

125042 T78906 Hs.269432 ESTs, Moderately similar to ALU1.HUMAN 21.80

124711 NM 004657 Hs.26530 serum deprivation response (phosphatidyl 10.60

124631 NM 014053 Hs.270594 FLVCR protein 23.20

124578 N68321 Hs.231500 EST 21.43

124574 AL036596 Hs.42322 A kinase (PRKA) anchor protein 2 1.77

124472 N52517 Hs.102670 EST 37.20

124438 BE178536 Hs.11090 membrane-spanning 4-domains, subfamily A

124357 N22401 gb:yw37g07.s1 Morton Fetal Cochlea Homo 14.64

124306 AW973078 Hs.293039 ESTs 4.00

124214 H58608 Hs.151323 ESTs

124097 AW298235 Hs.101689 ESTs 27.20

123978 T89832 Hs.170278 ESTs 2.03

123972 T46848 Hs.70337 immunoglobulin superfamily, member 4 6.00

123961 AL050184 Hs.21610 DKFZP434B203 protein 1.79

123936 NM 004673 Hs.241519 angiopoietin-like 1 15.80

123802 AA620448 gb:ae58c09.s1 Stratagene lung carcinoma 4.23

123734 AA609861 Hs.312447 ESTs 4.20

123619 AA602964 gb:πo97c02.s1 NCI CGAP Pr2 Homo sapiens 33.60

123596 AA421130 Hs.112640 EST 10.93

123476 AA384564 Hs.108829 ESTs 2.18

123340 AA504264 Hs.182937 peptidylprolyl isomerase A (cyclophilin 11.20

123190 AA489212 Hs.105228 EST 14.20

123136 AW451999 Hs.194024 ESTs 7.00

123073 AA485061 Hs.105652 ESTs 31.20

123055 AA482005 Hs.105102 ESTs, Weakly similar to reverse transcri 4.80

122699 AA456130 Hs.301721 KIAA1255 protein 5.00

122679 AA811286 Hs.192837 ESTs, Weakly similar to ALU5.HUMAN ALU S 14.40

122633 NM 01546 Hs.34853 inhibitor of DNA binding 4, dominant neg

122553 AA451884 Hs.190121 ESTs 40.00

122544 AW973253 Hs.292689 ESTs 15.40

122485 AA524547 Hs.160318 FXYD domain-containing ion transport reg 1.81

122211 AA300900 Hs.98849 ESTs, Moderately similar to AF161511 1 H 12.10

122127 AW207175 Hs.106771 ESTs 1.95

122011 AA431082 gb:zw78a10.s1 Soares testis NHT Homo sap 1.89

121992 AI860775 Hs.98506 ESTs 3.60

121989 W56487 Hs.193784 Homo sapiens mRNA; cDNA DKFZp586K1922 (f 2.01

121835 AB033030 Hs.300670 KIAA1204 protein 1.85

121726 AF241254 Hs.178098 angioteπsin I converting enzyme (peptidy 12.43

121690 AV660305 Hs.110286 ESTs 1.82

121643 AA640987 Hs.193767 ESTs

121633 AA417011 Hs.98175 EST 14.00

121622 AA416931 Hs.126065 ESTs 16.40

121497 AA412031 Hs.97901 EST 11.20

121351 AW206227 Hs.287727 hypothetical protein FLJ23132 12.20

121314 W07343 Hs.182538 phospholipid scramblase 4 1.83

121242 AA400857 Hs.97509 ESTs 22.40

121059 AA393283 gb:zt74e03.r1 Soares.testis.NHT Homo sap 14.80

120934 AA226198 gb:nc26a07.s1 NCI.CGAP.P Homo sapiens 21.20

120755 AA312934 Hs.190745 Homo sapiens cDNA: FLJ21326 fis, clone 1,79

120637 AA811804 gb:ob39a05.s1 NCI CGAP GCB1 Homo sapiens 20.00

120484 AA253170 Hs.96473 EST 40.20

120336 N85785 Hs.181165 eukaryotic translation elongation factor 6.60

120266 AI807264 Hs.205442 ESTs, Weakly similar to T34036 hypotheti 16.80

120132 W57554 Hs.125019 ESTs 4.73

120041 AA830882 Hs.59368 ESTs 1.75

119996 W88996 Hs.59134 EST 7.20

119970 AA767718 Hs.93581 hypothetical protein FLJ10512 11.20

119861 W78816 Hs.49943 ESTs, Weakly similar to S65657 alpha-1C- 3.78

119824 W74536 Hs.184 advanced glycosylation end product-speci

119740 AW021407 Hs.21068 hypothetical protein 20.20

119271 AI061118 Hs.65328 Fanconi anemia, complementation group F 15.20

119221 C14322 Hs.250700 tryptase beta 1

119126 R45175 Hs.117183 ESTs 12.60

119073 BE245360 Hs.279477 ESTs

118928 AA312799 Hs.283689 activator of CREM in testis 10.00

118901 AW292577 Hs.94445 ESTs 3.96

118661 AL137554 Hs.49927 protein kinase NYD-SP15 9.60

118607 AI377444 Hs.54245 ESTs, Weakly similar to S65824 reverse t 10.40

118449 AI813865 Hs.164478 hypothetical protein FLJ21939 similar to 1.90

118416 N66028 Hs.49105 FKBP-associated protein 16.20

118379 N64491 Hs.48990 ESTs 4.00

118329 N63520 gb:yy62f01.s1 Soares.multiple.sclerosis. 6.60

118320 N63451 Hs.141600 ESTs, Weakly similar to alternatively s 3.80

118253 AA497044 Hs.20887 hypothetical protein FLJ10392 17.60

118124 N56968 Hs.46707 chromosome 21 open reading frame 37 14.00

118056 AB037746 Hs.42768 hypothetical protein DKFZp76100113 1.86

118032 N52802 Hs.47544 ^■ EST 5.00

117840 T26379 Hs.48802 Homo sapiens clone 23632 mRNA sequence 4.00

117404 N39725 Hs.15220 zinc finger protein 106 1.90

117314 N32498 Hs.42829 ESTs 14.20 117209 W03011 Hs.306881 MSTP043 protein

117023 AW070211 Hs.102415 Homo sapiens mRNA; cDNA DKFZp586N0121 (f 2.31

116814 H50834 gb:yp86a10.s1 Soares fetal liver spleen 20.20

116784 AB007979 Hs.301281 Homo sapiens mRNA, chromosome 1 specific 3.51

116766 AI608657 Hs.95097 ESTs 16.20

116712 AW901618 Hs.61935 Homo sapiens mRNA; cDNA DKFZp761l071 (fr 6.80

116707 H10344 Hs.49050 ESTs, Weakly similar to A Chain A, Human 18.60

116351 AL133623 Hs.82501 similar to mouse Xrn1 / Dhm2 protein 19.40

116279 AW971248 Hs.291289 ESTs, Weakly similar to ALU1.HUMAN ALU S

116166 AL039940 Hs.202949 KIAA1102 protein 2.13

116152 AL040521 Hs.15220 zinc finger protein 106 1.75

116117 BE613410 Hs.31575 SEC63, endoplasmic reticulum translocon 13.20

116107 AL133916 Hs.172572 hypothetical protein FLJ20093 30.11

115965 AA001732 Hs.173233 hypothetical protein FLJ10970 2.36

115955 AF263613 Hs.44198 intracellular membrane-associated calciu 18.20

115844 AI373062 Hs.332938 hypothetical protein MGC5370 18.57

115683 AF255910 Hs.54650 junctional adhesion molecule 2 23.00

115673 AA406341 Hs.269908 Homo sapiens cDNA FLJ 11991 fis, clone HE 11.82

115672 AI889110 Hs.73251 ESTs 10.60

115566 AI142336 Hs.43977 Human DNA sequence from clone RP11-196N1 1.76

115313 AA808001 Hs.184411 albumin 25.20

115279 AW964897 Hs.290825 ESTs 8.00

115230 AA278300 Hs.124292 Homo sapiens cDNA: FLJ23123 fis, clone L 1.80

115110 AK001671 Hs.11387 KIAA1453 protein 14.20

114999 BE246481 Hs.87856 ESTs 19.20

114930 AA237022 Hs.188717 ESTs 5.60

114922 AA235672 Hs.87491 ESTs 3.60

114837 BE244930 Hs.166895 ESTs 43.70

114769 AA149060 Hs.296100 ESTs 11.00

114761 AA143781 Hs.126280 hypothetical protein FLJ23393 14.00

114736 AI610347 Hs.103812 ESTs, Moderately similar to ALU1.HUMAN A 4.20

114596 AA310162 Hs.169248 cytochrome c 10.71

114518 AW163267 Hs.106469 suppressor of varl (S.cerevisiae) 3-like 20.40

114455 H37908 Hs.271616 ESTs, Weakly similar to ALU8.HUMAN ALU S 20.40

114452 AI369275 Hs.243010 Homo sapiens cDNA FLJ 14445 fis, clone HE 17.20

114359 NM 016929 Hs.283021 chloride intracellular channel 5 2.09

114357 R41677 Hs.6107 Homo sapiens cDNA FLJ14839 fis, clone OV 12.40

114251 H15261 Hs.21948 ESTs 2.00

114138 AW384793 Hs.15740 Homo sapiens mRNA; cDNA DKFZp434E033 (fr 11.40

114124 W57554 Hs.125019 ESTs 6.04

113946 AW083883 Hs.37896 Homo sapiens cDNA FLJ13510 fis, clone PL 1.82

113695 T96965 Hs.17948 ESTs, Weakly similar to ALUB.HUMAN III!

113606 NM 013343 Hs.278951 NAG-7 protein 2.15

113590 R49642 Hs.142447 ESTs, Weakly similar to ALU1 HUMAN ALU S 3.60

113560 T91015 Hs.268626 ESTs 32.00

113552 AI654223 Hs.16026 hypothetical protein FLJ23191

113540 AW152618 Hs.16757 ESTs

113502 T89130 gb:ye12d01.s1 Stratagene lung (937210) H 8.35

113288 AI076838 Hs.12967 ESTs 12.40

113252 NM 004469 Hs.11392 c-fos induced growth factor (vascular en 4.27

113238 R45467 Hs.189813 ESTs

113203 AA743563 Hs.10305 ESTs 21.20

113195 H83265 Hs.8881 ESTs, Weakly similar to S41044 chromosom 1.92

113089 T40707 Hs.270862 ESTs 14.33

113076 AF033199 Hs.8198 zinc finger protein 204 6.00

113009 T23699 Hs.7246 ESTs 9.40

112937 AI694320 Hs.6295 ESTs, Weakly similar to T17248 hypotheti 12.20

112891 T03927 Hs.293147 ESTs, Moderately similar to A46010 X-li 10.57

112794 R97018 gb;yq74b08.s1 Soares fetal liver spleen 26.60

112691 R88708 Hs.220647 ESTs 15.33

112602 AW004045 Hs.203365 ESTs 15.60

112366 AF035318 Hs.12533 Homo sapiens clone 23705 mRNA sequence 15.40

112210 R49645 Hs.7004 ESTs 14.00

112064 AL049390 Hs.22689 Homo sapiens mRNA; cDNA DKFZp58601318 (f 13.00

111998 R42379 Hs.138283 ESTs 11.00

111987 NM.015310 Hs.6763 KIAA0942 protein 22.40

111803 AA593731 Hs.325823 ESTs, Moderately similar to ALU5 HUMAN A 1.77

111737 H04607 Hs.9218 ESTs 1.86

111605 T91061 Hs.194178 ESTs, Moderately similar to PC4259 ferri 23.00

111510 R07856 Hs.16355 ESTs 11.02

111341 AL157484 Hs.22483 Homo sapiens mRNA; cDNA DKFZp762M127 (fr 1.88

111280 AA373527 Hs.19385 CGI-58 protein 18.40

111247 AW058350 Hs.16762 Homo sapiens mRNA; cDNA DKFZp564B2062 (f

111232 AI247763 Hs.16928 ESTs 27.60

110942 R63503 Hs.28419 ESTs 14.80

110924 AW05S463 Hs.12940 zinc-fingers and ho eoboxes 1 24.71

110837 H03109 Hs.108920 HT018 protein 2.18

110824 AI767183 Hs.26942 ESTs 12.20

110776 AB032417 Hs.19545 frizzled (Drosophila) homolog 4 1.75

110576 H60869 Hs.37889 ESTs 13.00

110369 AK000768 Hs.107872 hypothetical protein FLJ20761 5.60

110099 R44557 Hs.23748 ESTs 2.31

109984 AI796320 Hs.10299 Homo sapiens cDNA FLJ13545 fis, clone PL

109958 AA001266 Hs.133521 ESTs 11.25

109893 AA884208 Hs.30484 ESTs 2.68 109842 AW818436 Hs.23590 solute carrier family 16 (monocarboxylic 23.83

109837 H00656 Hs.29792 ESTs, Weakly similar to I38022 hypotheti 3.91

109796 AI800515 Hs.12024 ESTs 17.20

109688 R41900 Hs.22245 ESTs 9.60

109648 H17800 Hs.7154 ESTs 22.80

109613 H47315 Hs.27519 ESTs

109550 AW021488 Hs.26981 ESTs

109523 AW193342 Hs.24144 ESTs 1.89

109472 AK001989 Hs.91165 hypothetical protein 6.00

109355 AA524525 Hs.48297 DKFZP586C1620 protein 15.00

109260 AW978515 Hs.131915 KIAA0863 protein 25.60

108781 AA128654 gb:zn98g07.s1 Stratagene fetal retina 93 14.20

108663 BE219231 Hs.292653 ESTs, Weakly similar to T26845 hypotheti 11.00

108573 AA086005 gb:zl84c04.s1 Stratagene colon (937204) 26.00

108480 AL133092 Hs.68055 hypothetical protein DKFZp434l0428

108382 NM.006770 Hs.67726 macrophage receptor with collagenous str 1.83

108174 AA055632 Hs.303070 ESTs 15.20

108138 AL049990 Hs.51515 Homo sapiens mRNA; cDNA DKFZp564G112 (fr 3.60

108087 AA045708 Hs.40545 ESTs 15.44

108048 AI797341 Hs.165195 Homo sapiens cDNA FLJ14237 fis, clone NT 11.40

108041 AW204712 Hs.61957 ESTs

107997 AL049176 Hs.82223 chordin-like 4.76

107994 AA036811 Hs.48469 LIM domains containing 1

107922 BE153855 Hs.61460 Ig superfamily receptor LNIR 14.20

107681 BE379594 Hs.49136 ESTs, Moderately similar to ALU7.HUMAN A 51.80

107666 AA010611 Hs.60418 EST 29.20

107332 T87750 Hs.183297 DKFZP566F2124 protein 10.73

107292 BE166479 Hs.4789 Homo sapiens serologically defined breas 32.00

107230 AI034467 Hs.34650 ESTs 17.40

107168 W57578 Hs.237955 RAB7, member RAS oncogene family 10.43

107160 AA314490 Hs.27669 KIAA1563 protein 11.40

107054 AI076459 Hs.15978 KIAA1272 protein

107029 AF264750 Hs.288971 myeloid/lymphoid or mixed-lineage leukem 21.40

106999 H93281 Hs.10710 hypothetical protein FLJ20417 35.80

106954 AF128847 Hs.204038 indolethylamine N-methyltransferase 1.76

106870 AI983730 Hs.26530 serum deprivation response (phosphatidyl

106865 AW192535 Hs.19479 ESTs 13.40

106844 AA485055 Hs.158213 sperm associated antigen 6 7.13

106820 NM 016831 Hs.12592 period (Drosophila) homolog 3 7.00

106818 AK002135 Hs.3542 hypothetical protein FLJ11273 13.00

106797 AI768801 Hs.169943 Homo sapiens cDNA FLJ13569 fis, clone PL 2.05

106773 AA478109 Hs.188833 ESTs

106747 NM_007118 Hs.171957 triple functional domain (PTPRF interact 12.60

106743 BE613328 Hs.21938 hypothetical protein FLJ12492 10.60

106667 AW360847 Hs.16578 ESTs

106605 AW772298 Hs.21103 Homo sapiens mRNA; cDNA DKFZp564B076 (fr 2.40

106567 AW450408 Hs.86412 chromosome 9 open reading frame 5 1.78

106562 AL031846 Hs.152151 plakophilin 4 1.76

106536 AA329648 Hs.23804 ESTs, Weakly similar to PN0099 son3 prat 2.19

106533 AL134708 Hs.145998 ESTs 23.20

106507 AA259068 Hs.267819 protein phosphatase 1, regulatory (inhib 15.20

106490 AA404265 Hs.115537 putative dipeptidase

106474 BE383668 Hs.42484 hypothetical protein FLJ10618 10.44

106211 AA428240 Hs.126083 ESTs 29.80

105986 AB037722 Hs.8707 KIAA1301 protein 3.70

105894 AI904740 Hs.25691 receptor (calcitonin) activity modifying 1.94

105847 AW964490 Hs.32241 ESTs, Weakly similar to S65657 alpha-1 C- 1.75

105803 AW747996 Hs.160999 ESTs, Moderately similar to A56194 throm 2.47

105731 AA834664 Hs.29131 nuclear receptor coactivator 2 10.71

105729 H46612 Hs.293815 Homo sapiens HSPC285 mRNA, partial eds

105688 AI299139 Hs.17517 ESTs 23.40

105510 Z42047 Hs.283978 Homo sapiens PR02751 mRNA, complete eds 37.20

105101 H63202 Hs.38163 ESTs 8.30

104989 R65998 Hs.285243 hypothetical protein FLJ22029 8.09

104986 AW088826 Hs.117176 poly(A)-binding protein, nuclear 1 1.92

104969 AI670947 Hs.78406 phosphatidylinositol-4-phosphate 5-kinas 5.40

104903 AI436323 Hs.31141 Homo sapiens mRNA for KIAA1568 protein, 7.60

104896 AW015318 Hs.23165 ESTs 13.80

104865 T79340 Hs.22575 Homo sapiens cDNA: FLJ21042 fis, clone C

104825 AA035613 Hs.141883 ESTs 1.87

104781 AA099904 Hs.21610 DKFZP434B203 protein 1.93

104776 AA026349 gb:zj99f01.s1 Soares_pregnant.uterus.NbH 10.20

104691 U29690 Hs.37744 Homo sapiens beta-1 adrenergic receptor 5.69

104667 AI239923 Hs.30098 ESTs 3.82

104404 H58762 gb:EST00057 HE6W Homo sapiens cDNA clone 4.20

104392 AA076049 Hs.274415 Homo sapiens cDNA FLJ10229 fis, clone HE 27.20

104212 AB002298 Hs.173035 KIAA0300 protein 1.91

104074 AL162039 Hs.31422 Homo sapiens mRNA; cDNA DKFZp434M229 (fr 11.20

103749 AL135301 Hs.8768 hypothetical protein FLJ 10849 10.86

103645 AW246253 Hs.7043 succinale-CoA ligase, GDP-forming, alpha 12.00

103554 AI878826 Hs.323469 caveolin 1, caveolae protein, 22kD 1.80

103541 AI815601 Hs.79197 CD83 antigen (activated B lymphocytes, i

103496 Y09267 Hs.132821 flavin containing monooxygenase 2

103428 BE383507 Hs.78921 A kinase (PRKA) anchor protein 1 11.20

103353 X89399 Hs.119274 RAS p21 protein activator (GTPase activa 19.80 103295 X81479 Hs.2375 egf-like module containing, mucin-like, 3.60

103280 U84722 Hs.76206 cadherin 5, type 2, VE-cadherin (vascula

103100 NM 005574 Hs.184585 LIM domain only 2 (rhombotin-like 1) 1.76

103025 NM 002837 Hs.123641 protein tyrosine phosphatase, receptor t 2.15

102698 M18667 Hs.1867 progastricsin (pepsinogen C)

102659 BE245169 Hs.211610 CUG triplet repeat, RNA-biπding protein 11.00

102580 U60808 Hs.152981 CDP-diacylglycerol synthase (phosphatida 25.40

102417 AA034127 Hs.153487 signal transducing adaptor molecule (SH3 14.00

102363 NM 003734 Hs.198241 amine oxidase, copper containing 3 (vase

102302 AA306342 Hs.69171 protein kinase C-like 2 10.86

102283 AW161552 Hs.83381 guanine nucleotide binding protein 11

102188 U20350 Hs.78913 chemokine (C-X3-C) receptor 1 7.40

102151 T27013 Hs.3132 steroidogenic acute regulatory protein 16.40

101957 L28824 Hs.74101 spleen tyrosine kinase 15.40

101842 M93221 Hs.75182 mannose receptor, C type 1

101771 NML002432 Hs.153837 myeloid cell nuclear differentiation ant

101764 AI198550 Hs.81256 S100 calcium-binding protein A4 (calcium 1.78

101716 AF050658 Hs.2563 tachykinin, precursor 1 (substance K, su 18.80

101678 M62505 Hs.2161 complement component 5 receptor 1 (C5a I 2.22

101447 M21305 gb:Human alpha satellite and satellite 3 504.80

101383 NM 000132 Hs.79345 coagulation factor VIII, procoagulant co 31.00

101346 AI738616 Hs.77348 hydroxyprastaglandin dehydrogenase 15-(N 1.75

101345 NM.005795 Hs.152175 calcitonin receptor-like

101336 NM.006732 Hs.75678 FBJ murine osteosarcoma viral oncogene h 2.24

101330 L43821 Hs.80261 enhancer of filamentation 1 (cas-like do

101277 BE297626 Hs.296049 microfibrillar-associated protein 4

101262 L35854 gb:Human dystrophin (dp140) mRNA, 5' end 19.00

101168 NM 005308 Hs.211569 G protein-coupled receptor kinase 5 2.01

101102 NM 003243 Hs.79059 transforming growth factor, beta recepto

101088 X70697 Hs.553 solute carrier family 6 (neurotransmitte 7.52

101066 AW970254 Hs.889 Charot-Leyden crystal protein 19.38

100971 BE379727 Hs.83213 fatty acid binding protein 4, adipocyte 1.91

100893 BE245294 Hs.180789 S164 protein 15.40

100770 W25797.com- i Hs.177486 amyloid beta (A4) precursor protein (pro 11.20

100716 X89887 Hs.172350 HIR (histoπe cell cycle regulation defec 14.80

100555 M69181 gb:Human nonmuscle myosin heavy chain-B 33.00

100425 NM 014747 Hs.78748 KIAA0237 gene product 16.20

100408 D86640 Hs.56045 src homology three (SH3) and cysteine ri 4.00

100382 D83407 Hs.156007 Down syndrome critical region gene 1-lik 4.24

100351 D64158 6.20

100299 D49493 Hs.2171 growth differentiation factor 10 21.20

100134 AA305746 Hs.49 macrophage scavenger receptor 1

100108 U09577 Hs.76873 hyaluronoglucosaminidase 2 1.79

100095 Z97171 Hs.78454 myocilin, trabecular meshwork inducible 5.40

100066 11.29

TABLE 3B shows the accession numbers for those primekeys lacking unigenelD's for Table 3A. For each probeset we have listed the gene cluster number from which the oligonucleotides were designed. Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs. These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California). The Genbank accession numbers for sequences comprising each cluster are listed in the "Accession" column.

Pkey: Unique Eos probeset identifier number CAT number: Gene cluster number

Accession: Genbank accession numbers

Pkey CAT number Accessions

123619 371681 1 A AAA660022996644AAAA660099220000

126433 127143.1 A AAA332255660066AAAA009999551177 NN88!9423

125831 1522905 1 H H0044004433 DD6600998888 DD6600333377

126816 122973.1 A AAA224488223344AAAA009900998855

126852 136135 1 A AAA339999996611 AAAA112288334477

121059 273450.1 A AAA339933228833 AAAA339988662288

120637 200885 1 A AAA881111880044AAAA880099440044AAAA;286907 AW977624

122011 7617.-2 A AAA443311008822

120934 177521.1 A AAA222266119988AAAA222266551133AAAA:383773

123802 genbaπk_AA620448 A AAA662200444488

116814 genbank_H50834 H H5500883344

118329 genbank_N63520 N N6633552200

104404 H58762_at H58762

104776 genbank_AA026349 A AAA002266334499

113502 genbank_T89130T89130

101262 entrez_L35854 L35854

108573 genbank_AA086005 A AAA008866000055

101447 entrez_M21305 M21305

124357 genbank_N22401 N N2222440011

108781 genbaπk_AA128654 A AAA112288665544

112794 genbank_R97018 R R9977001188

100351 entrez_D64158 D64158

100555 tigr_HT2245 M69181 M81105 U51039 Table 4A shows 202 genes up-regulated in samples from patients treated with chemotherapy or radiotherapy. These genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression.

Pkey: Unique Eos probeset identifier number

ExAccn: Exemplar Accession number, Genbank accession number

UnigenelD: Unigene number

Unigene Title: Unigene gene title

R1: average of Al for samples from patients treated with chemotherapy or radiotherapy divided by the average of Al for normal lung samples.

Pkey ExAccn UnigenelD Unigene Title R1

100113 NM.001269 Hs.84746 chromosome condensation 1 27.20

100187 D17793 Hs.78183 aldo-keto reductase family 1, member C3 20.60

100210 D26361 Hs.3104 KIAA0042 gene product - 20.40

100225 D28539 Hs.167185 glutamate receptor, metabotropic 5 20.60

100269 NM.001949 Hs.1189 E2F transcription factor 3 29.40

100438 AA013051 Hs.91417 topoisomerase (DNA) II binding protein 23.50

100877 X80821 Hs.27973 KIAA0874 protein 35.56

100893 BE245294 Hs.180789 S164 protein 43.40

101273 Z11933 Hs.182505 POU domain, class 3, transcription facto 21.80

101447 M21305 gb:Human alpha satellite and satellite 3 193.60

101649 AW959908 Hs.1690 heparin-binding growth factor binding pr 38.40

101724 L11690 Hs.620 bullous pemphigoid antigen 1 (230/240kD) 198.80

101748 NM.001944 Hs.1925 desmoglein 3 (pemphigus vulgaris antigen 78.60

101809 M86849 Hs.323733 gap junction protein, beta 2, 26kD (conn 162.20

101879 AA176374 Hs.243886 nuclear autoantigenic sperm protein (his 50.00

101915 AF207881 Hs.155185 cytosolic ovarian carcinoma antigen 1 26.00

101973 U41514 Hs.80120 UDP-N-acetyl-alpha-D-galactosamine:polyp 37.20

102025 U04045 Hs.78934 mutS (E. coli) homolog 2 (colon cancer,

102031 U04898 Hs.2156 RAR-related orphan receptor A 32.00

102052 NM.002202 Hs.505 ISL1 transcription factor, LIM/homeodoma 51.20

102391 AA296874 Hs.77494 deoxyguanosine kinase 13.90

102420 U44060 Hs.14427 Homo sapiens cDNA: FLJ21800 fis, clone H 28.80

102610 U65011 Hs.30743 preferentially expressed antigen in ela 110.60

102829 NM.006183 Hs.80962 πeurotensiπ 116.80

103000 NM.001975 Hs.146580 enolase 2, (gamma, neuronal) 2.30

103036 M13509 Hs.83169 matrix metalloproteinase 1 (interstitial 181.40

103507 AJ000512 Hs.296323 serum/glucocorticoid regulated kinase 49.20

103587 BE270266 Hs.82128 5T4 oncofetal trophoblast glycoprotein 86.60

104660 BE298665 Hs.14846 Homo sapiens mRNA; cDNA DKFZp564D016 (fr 42.60

104896 AW015318 Hs.23165 ESTs 29.40

105038 AW503733 Hs.9414 KIAA1488 protein 21.50

105298 BE387790 Hs.26369 hypothetical protein FLJ20287 32.80

105510 Z42047 Hs.283978 Homo sapiens PR02751 mRNA, complete eds 20.20

105667 AA767526 Hs.22030 paired box gene 5 (B-cell lineage specif 28.40

106073 AL157441 Hs.17834 downstream neighbor of SON 25.40

106205 AW965058 Hs.111583 ESTs, Weakly similar to I38022 hypotheti 32.00

106516 AL137311 Hs.234074 Homo sapiens mRNA; cDNA DKFZp761G02121 ( 40.60

106533 AL134708 Hs.145998 ESTs 59.80

106575 AW970602 Hs.105421 ESTs 43.40

106654 AW075485 Hs.286049 phosphoserine aminotransferase 50.80

106851 AI458623 gb:tk04g09.x1 NCI CGAP_Lu24 Homo sapiens 53.40

106995 AB023139 Hs.37892 KIAA0922 protein 20.88

107332 T87750 Hs.183297 DKFZP566F2124 protein 23.60

107532 AA443473 Hs.173684 Homo sapiens mRNA; cDNA DKFZp762G207 (fr 57.20

107922 BE153855 Hs.61460 Ig superfamily receptor LNIR 49.00

108609 BE409857 Hs.69499 hypothetical protein 19.67

108780 AU076442 Hs.117938 collagen, type XVII, alpha 1 48.17

109166 AA219691 Hs.73625 RAB6 interacting, kinesin-like (rabkines 59.20

109260 AW978515 Hs.131915 KIAA0863 protein 28.60

109280 AK001355 Hs.279610 hypothetical protein FLJ10493 22.80

109292 AW975746 Hs.188662 KIAA1702 protein

109384 AA219172 Hs.86849 ESTs 21.00

109415 U80736 Hs.110826 trinucleotide repeat containing 9 31.60

109445 AA232103 Hs.189915 ESTs 24.20

109502 AW967069 Hs.211556 hypothetical protein MGC5487 21.40

109633 AW003785 Hs.170267 ESTs 20.40

109786 AI989482 Hs.146286 kinesin family member 13A 19.60

109958 AA001266 Hs.133521 ESTs 24.00

110920 N47224 Hs.20521 HMT1 (hnRNP methyltransferase, S. cerevi 28.40

110924 AW058463 Hs.12940 zinc-fingers and homeoboxes 1 36.00

111084 H44186 Hs.15456 PDZ domain containing 1 61.20

111132 AB037807 Hs.83293 hypothetical protein 24.60

111229 AW389845 Hs.110855 ESTs 27.20

111337 AA837396 Hs.263925 LIS1-iπteracting protein NUDE1, rat homo 48.00

111987 NM 015310 Hs.6763 KIAA0942 protein 37.80

112046 AA383343 Hs.22116 CDC14 (cell division cycle 14, S. cerevi 26.80

112268 W39609 Hs.22003 solute carrier family 6 (πeurotraπsmitte 63.80

112685 R87650 Hs.33439 ESTs, Weakly similar to ALU1.HUMAN ALU 26.40

112871 AL110216 Hs.12285 ESTs, Weakly similar to 155214 salivary 47.64

112897 AW206453 Hs.3782 ESTs 22.00

112973 AB033023 Hs.318127 hypothetical protein FLJ 10201 65.00

112992 AL157425 Hs.133315 Homo sapiens mRNA; cDNA DKFZp761 J1324 (f 42.00

113073 N39342 Hs.103042 microtubule-associated protein 1B 55.40 113494 T91451 Hs.86538 ESTs 22.80

113560 T91015 Hs.268626 ESTs 22.80

113849 AA457211 Hs.8858 bromodomain adjacent to zinc finger doma 51.80

113950 AI267652 Hs.30504 Homo sapiens mRNA; cDNA DKFZp434E082 (fr 28.20

114339 AA782845 Hs.22790 ESTs 20.20

114365 H42169 Hs.18653 hypothetical protein FLJ14627 21.00

114455 H37908 Hs.271616 ESTs, Weakly similar to ALU8.HUMAN ALU S 25.80

114518 AW163267 Hs.106469 suppressor of varl (S.cerevisiae) 3-like 23.60

114824 AA960961 Hs.305953 zinc finger protein 83 (HPF1) 27.20

114837 BE244930 Hs.166895 ESTs 30.20

114974 AW966931 Hs.179662 nuoleosome assembly protein 1-like 1 20.80

115075 AA814043 Hs.88045 ESTs 30.60

115084 BE383668 Hs.42484 hypothetical protein FLJ10618 28.86

115291 BE545072 Hs.122579 hypothetical protein FLJ10461 38.00

115313 AA808001 Hs.184411 albumin 22.60

115697 D31382 Hs.63325 transmembrane protease, serine 4 173.60

115909 AW872527 Hs.59761 ESTs, Weakly similar to DAP1 HUMAN DEATH 27.77

116090 AI591147 Hs.61232 ESTs 20.80

116107 AL133916 Hs.172572 hypothetical protein FLJ20093 164.20

116399 AA889120 Hs.110637 homeo boxAIO 38.00

117099 H93699 gb:yv16a11.s1 Soares fetal liver spleen 21.60

117881 AF161470 Hs.260622 butyrate-induced transcript 1 49.40

118091 AW005054 Hs.47883 ESTs, Weakly similar to KCC1.HUMAN CALCI 22.40

118138 AA374756 Hs.93560 Homo sapiens mRNA for KIAA1771 protein, 22.00

118720 N73515 gb:za49d07.s1 Soares fetal liver spleen 20.00

118873 AI824009 Hs.44577 ESTs 19.40

119126 R45175 Hs.117183 ESTs 111.20

119717 AA918317 Hs.57987 B-cell CLL/lymphoma 118 (zinc finger pro 33.00

119940 AL050097 Hs.272531 DKFZP586B0319 protein 31.00

120266 AI807264 Hs.205442 ESTs, Weakly similar to T34036 hypotheti 20.20

120515 AA258356 gb:zr59c10.s1 Soares.NhHMPu.S1 Homo sapi 25.00

120859 AA826434 Hs.1619 achaete-scute complex (Drosophila) homol 95.40

120983 AA398209 Hs.97587 EST 105.20

121054 AW976570 Hs.97387 ESTs 38.80

121369 AW450737 Hs.128791 CGI-09 protein 41.60

122335 AA443258 Hs.241551 chloride channel, calcium activated, fam 30.80

122612 AA974832 Hs.128708 ESTs 19.60

123130 AA487200 gb:ab19f02.s1 Stratagene lung (937210) H 33.20

123440 AI733692 Hs.112488 ESTs 23.17

123596 AA421130 Hs.112640 EST 23.00

123619 AA602964 gb:no97c02.s1 NCI CGAP_Pr2 Homo sapiens 28.80

124006 AI147155 Hs.270016 ESTs 77.60

124169 BE079334 Hs.271630 ESTs 22.20

124281 AI333756 Hs.111801 arsenate resistance protein ARS2 42.20

124472 N52517 Hs.102670 EST 32.60

124617 AW628168 Hs.152684 ESTs 21.80

124631 NM 014053 Hs.270594 FLVCR protein 30.40

124839 R55784 Hs.140942 ESTs 21.20

125186 AA610620 Hs.181244 major histocompatibility complex, class 42.80

125321 T86652 Hs.178294 ESTs 27.00

125535 NM 013243 Hs.22215 εecretogranin III 23.80

125646 AA628962 Hs.75209 protein kinase (cAMP-dependent, catalyti 23.20

125684 AW589427 Hs.158849 Homo sapiens cDNA: FLJ21663 fis, clone C 21.20

125724 AL360190 Hs.295978 Homo sapiens mRNA full length insert cDN 48.80

125847 AW161885 Hs.249034 ' ESTs 31.00

125934 AA193325 Hs.32646 hypothetical protein FLJ21901 21.20

126077 M78772 Hs.210836 ESTs 49.80

126299 AW979155 Hs.298275 amino acid transporter 2 21.80

126395 AI468004 Hs.278956 hypothetical protein FLJ 12929 71.00

126433 AA325606 gb:EST28707 Cerebellum II Homo sapiens c 23.20

126509 R47400 Hs.23850 ESTs 23.80

126538 AB030656 Hs.17377 coronin, actin-biπding protein, 1C 23.10

126666 AA648886 Hs.151999 ESTs 36.00

126812 AB037860 Hs.173933 nuclear factor l/A 20.80

126872 AW450979 gb:UI-H-BI3-ala-a-12-0-Ul.s1 NCI.CGAP Su 46.29

127046 AA321948 Hs.293968 ESTs 22.80

127431 AW771958 Hs.175437 ESTs, Moderately similar to PC4259 ferri 30.00

127489 AA650250 Hs.272076 ESTs 20.80

127521 AW297206 Hs.164018 ESTs 25.20

127742 AW293496 Hs.180138 ESTs 28.00

127925 AA805151 Hs.3628 mitogen-activated protein kinase kinase 21.20

127930 AA809672 Hs.123304 ESTs 20.54

127968 AA830201 Hs.124347 ESTs 28.20

127987 AI022103 Hs.124511 ESTs 19.60

128116 H07103 Hs.286014 Homo sapiens, clone IMAGE:3867243, mRNA 20.40

128609 NM.003616 Hs.102456 survival of motor neuron protein iπterac 34.40

128777 AI878918 Hs.10526 cysteine and glycine-rich protein 2 53.80

128949 AA009647 Hs.8850 a disiπtegrin and metalloproteinase doma 23.00

129168 AI132988 Hs.109052 chromosome 14 open reading frame 2 37.60

129404 AI267700 Hs.317584 ESTs 28.60

129527 AA769221 Hs.270847 delta-tubulin 40.80

129574 AA026815 Hs.11463 UMP-CMP kinase 31.20

129598 N30436 Hs.11556 Homo sapiens cDNA FLJ12566 fis, clone NT 29.60

129785 H19006 Hs.184780 ESTs 72.20

129970 AV655806 Hs.296198 chromosome 12 open reading frame 4 22.20 130149 AW067805 Hs.172665 methylenetetrahydrofolate dehydrogenase 29.60

130199 Z48579 Hs.172028 a disintegrin and metalloproteinase doma 27.60

130441 U63630 Hs.155637 protein kinase, DNA-activated, catalytic 28.36

130466 W19744 Hs.180059 Homo sapiens cDNA FLJ20653 fis, clone KA 20.20

130482 AW409701 Hs.1578 baculoviral IAP repeat-containing 5 (sur 22.40

130617 M90516 Hs.1674 glutamine-fructose-6-phosphate transamin 19.60

130703 R77776 Hs.18103 ESTs ^• 19.40

130732 AW890487 Hs.63984 cadherin 13, H-cadherin (heart) 21.40

130867 NM.001072 Hs.284239 UDP glycosyltransferase 1 family, polype 110.00

131028 AI879165 Hs.2227 CCAAT/enhancer binding protein (C/EBP), 25.20

131086 AL035461 Hs.2281 chromogranin B (secretogranin 1) 40.60

131284 NM 001429 Hs.25272 E1 A binding protein p300 24.60

131775 AB014548 Hs.31921 KIAA0648 protein 21.00

131860 BE383676 Hs.334 Rho guanine nucleotide exchange factor ( 33.40

131945 NM 002916 Hs.35120 replication factor C (activator 1) 4 (37 60.80

132040 NM.001196 Hs.315689 Homo sapiens cDNA: FLJ22373 fis, clone H 20.40

132084 NM 002267 Hs.3886 karyopherin alpha 3 (importin alpha 4) 29.40

132389 AA310393 Hs.190044 ESTs 32.40

132437 AA152106 Hs.4859 cycliπ L anϊa-6a 27.40

132550 AW969253 Hs.170195 bone morphogenetic protein 7 (osteogenic 75.60

132617 AF037335 Hs.5338 carbonic anhydrase XII 31.36

132632 AU076916 Hs.5398 guanine moπphosphate synthetase 32.40

132672 W27721 Hs.54697 Cdc42 guanine exchange factor (GEF) 9 23.40

132742 AA025480 Hs.292812 ESTs, Weakly similar to T33468 hypotheti 61.20

132771 Y10275 Hs.56407 phosphoserine phosphatase 22.33

133070 U92649 Hs.64311 a disintegrin and metalloproteinase doma 23.50

133153 AF070592 Hs.66170 HSKM-B protein 30.00

133181 X91662 Hs.66744 twist (Drosophila) homolog (acrocephalos 23.80

133282 AA449015 Hs.286145 SRB7 (suppressor of RNA polymerase B, ye 51.60

133350 AI499220 Hs.71573 hypothetical protein FLJ 10074 33.00

133592 AV652066 Hs.75113 general transcription factor IIIA 82.00

133658 AA319146 Hs.75426 secretogranin II (chromogranin C)

133865 AB011155 Hs.170290 discs, large (Drosophila) homolog 5 69.33

134032 NM 005025 Hs.78589 serine (or cysteine) proteinase inhibito 33.20

134125 NM 014781 Hs.50421 KIAA0203 gene product 31.60

134158 U15174 Hs.79428 BCL2/adeπovirus E1B 19kD-interacting pro 30.60

134321 BE538082 Hs.8172 ESTs, Moderately similar to A46010 X-lin 23.40

134367 AA339449 Hs.82285 phosphoribosylglycinamide formyltransfer 49.20

134570 U66615 Hs.172280 SWI/SNF related, matrix associated, acli 20.20

134753 NM 006482 Hs.173135 dual-specificity tyrosine-(Y)-phosphoryl 20.80

135002 AA448542 Hs.251677 G antigen 7B 37.60

135029 H58818 Hs.187579 hydroxysteroid (17-beta) dehydrogenase 53.40

135047 AL134197 Hs.93597 cyclin-dependent kinase 5, regulatory su 31.60

135345 X53655 Hs.99171 neurotrophin 3 28.80

TABLE 4B shows the accession numbers for those primekeys lacking unigenelD's for Table 4A. For each probeset we have listed the gene cluster number from which the oligonucleotides were designed. Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs. These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California). The Genbank accession numbers for sequences comprising each cluster are listed in the "Accession" column.

Pkey: Unique Eos probeset identifier number

CAT number: Gene cluster number Accession: Genbank accession numbers

Pkey CAT number Accessions

123619 371681 1 AA602964AA609200 126433 127143 1 AA325606 AA099517 N89423 126872 142696.1 AW450979 AA136653 AA136656 AW419381 AA984358 AA492073 BE168945 AA809054 AW238038 BE011212 BE011359

BE011367 BE011368 BE011362 BE011215 BE011365 BE011363

106851 322947 1 AI458623 AA639708 AA485409 R22065 AA485570 118720 genbank_N73515 N73515 120515 genbank_AA258356 AA258356 117099 321871 1 H93699 H97976 H80036 101447 entrez M21305 M21305 123130 genbank_AA487200 AA487200

Table 5A shows 680 genes up-regulated in squamous cell carcinoma or adenocarcinoma lung tumors relative to normal lung and chronically diseased lung. These genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey: Unique Eos probeset identifier number

ExAccn: Exemplar Accession number, Genbank accession number

UnigenelD: Unigene number

Unigene Title: Unigene gene title

R1 : 70th percentile of Al for squamous cell carcinoma and adenocarcinoma lung tumor samples divided by the 90th percentile of Al for normal and chronically diseased lung samples.

R2: 80th percentile of Al adenocarcinoma lung tumor samples divided by the 90th percentile of Al for normal and chronically diseased lung samples.

R3: 80th percentile of Al squamous cell carcinoma lung tumor samples divided by the 90th percentile of Al for normal and chronically diseased lung samples.

R4: 80th percentile of Al adenocarcinoma lung tumor samples divided by the 80th percentile of Al for squamous cell carcinoma lung tumor samples.

R5: 70th percentile of Al for squamous cell carcinoma and adenocarcinoma lung tumor samples minus the 15th percentile of Al for all normal lung, chronically diseased lung and tumor samples divided by 90th percentile of Al for normal and chronically diseased lung samples minus the 15th percentile of Al for all normal lung, chronically diseased lung and tumor samples

Pkey ExAccn UnigenelD Unigene Title R1 R2 R3 R4 R5

100035 AFFX control: GAPDH 6.76

100036 AFFX control: GAPDH 5.77

100037 AFFX control: GAPDH 5.75

100071 A28102 Human GABAa receptor aIpha-3 subunit 8.00

100114 X02308 Hs.82962 thymidylate synthetase 5.71

100154 H60720 Hs.81892 KIAA0101 gene product 3.84

100187 D17793 Hs.78183 aldo-keto reductase family 1 , member C3 3.33

100188 AW247090 Hs.57101 minichromosome maintenance deficient (S. 4.52

100202 BE294407 Hs.99910 phosphofructokinase, platelet 5.49

100216 AA489908 Hs.1390 proteasome (prosome, macropain) subunit, 5.67

100269 NM 001949 Hs.1189 E2F transcription factor 3 2.55

100287 AU076657 Hs.1600 chaperonin containing TCP1, subunit 5 (e 5.66

100297 AU077258 Hs.182429 protein disulfide isomerase-related prot 3.81

100330 AW410976 Hs.77152 minichromosome maintenance deficient (S. 4.50

100335 AW247529 Hs.6793 platelet-activating factor acetylhydrola 5.07

100360 W70171 Hs.75939 uridine monophosphate kinase 4.82

100372 NM 014791 Hs.184339 KIAA0175 gene product 3.79

100474 NM 000699 Hs.300280 amylase, alpha 2A; pancreatic 15.65

100486 T19006 Hs.10842 RAN, member RAS oncogene family 5.49

100491 D56165 Hs.275163 non-metastatic cells 2, protein (NM23B) 4.17

100516 D90278 Hs.11 carcinoembryonic antigen-related cell ad 7.20

100522 X51501 Hs.99949 prolactin-induced protein 14.20

100559 NM 000094 Hs.1640 collagen, type VII, alpha 1 (epidermolys 3.10

100576 X00356 Hs.37058 calcitonin/calcitonin-related polypeptid 9.30

100629 AA015693 Hs.21291 mitogen-activated protein kinase kinase 20.60

100661 BE623001 Hs.132748 Homo sapiens ribosomal protein L39 mRNA, 3.85

100677 AA353686 Hs.57813 zinc ribbon domain containing, 1 8.60

100696 D14887 Hs.121686 general transcription factor IIA, 1 (37k 10.00

100709 N26539 Hs.100469 myeloid/lymphoid or mixed-lineage leukem 24.80

100761 BE208491 Hs.295112 KIAA0618 gene product 7.60

100830 AC004770 Hs.4756 flap structure-specific endonuclease 1 7.99

100867 U14622 gb:Human transketolase-like protein gene 10.20

100902 M16029 Hs.287270 ret proto-oncogene (multiple endocrine n 8.00

100906 AU076916 Hs.5398 guanine monphosphate synthetase 5.16

100960 J00124 Hs.117729 keratin 14 (epidermolysis bullosa simple 2.57

101045 J05614 gb:Human proliferating cell nuclear and 4.69

101061 NM 000175 Hs.180532 glucose phosphate isomerase 4.19

101071 L02840 Hs.84244 potassium voltage-gated channel, Shab-re 12.91

101124 L10343 Hs.112341 protease inhibitor 3, skin-derived (SKAL 3.12

101175 U82671 Hs.36980 melanoma antigen, family A, 2 3.50

101181 BE262621 Hs.73798 macrophage migration inhibitory factor ( 5.69

101204 L24203 Hs.82237 ataxia-telangiectasia group D-associated 4.08

101210 L29301 Hs.2353 opioid receptor, mu 1 6.40

101216 AA284166 Hs.84113 cyclin-depeπdent kinase inhibitor 3 (CDK 2.53

101228 AA333387 Hs.82916 chaperonin containing TCP1 , subunit 6A ( 7.90

101233 AL135173 Hs.878 sorbitol dehydrogenase 4.45

101273 Z11933 Hs.182505 POU domain, class 3, transcription facto 8.50

101342 U52112 Hs.182018 interleukin-1 receptor-associated kinase 4.17

101346 AI738616 Hs.77348 hydroxyprostaglandin dehydrogenase 15-(N 21.89

101369 NM.000892 Hs.1901 kallikrein B, plasma (Fletcher factor) 1 12.80

101396 BE267931 Hs.78996 proliferating cell nuclear antigen 3.24

101431 BE185289 Hs.1076 small proline-rich protein 1B (cornifin) 7.90

101448 NM 000424 Hs.195850 keratin 5 (epidermolysis bullosa simplex 8.31

101462 AL035668 Hs.73853 bone morphogenetic protein 2 38.80

101466 BE262660 Hs.170197 glutamic-oxaloacetic transaminase 2, mit 4.01

101484 AA053486 Hs.20315 interferon-iπduced protein with tetratri 12.00

101502 M26958 gb:Human parathyroid hormone-related pro - 10.50

101505 AA307680 Hs.75692 asparagine synthetase 4.46

101526 NM.002197 Hs.154721 aconitase l, soluble 4.02

101535 X57152 Hs.99853 fibrillarin 4.65

101577 M34353 Hs.1041 v-ros avian UR2 sarcoma virus oncogene h 9.09

101649 AW959908 Hs.1690 heparin-binding growth factor binding pr 54.00

101663 NM.003528 Hs.2178 H2B histone family, member Q 5.59

101664 AA436989 Hs.121017 H2A histone family, member A 7.00

101669 L24498 Hs.80409 growth arrest and DNA-damage-inducible, 7.60 101695 M69136 Hs 135626 chymase 1, mast cell 479

101724 L11690 Hs 620 bullous pe phigoid antigen 1 (230/240kD) 1521

101748 NM 001944 Hs 1925 desmoglein 3 (pemphigus vulgaπs antigen 5550

101759 M80244 Hs 184601 solute earner family 7 (cationic ammo 410

101771 NM 002432 Hs 153837 myeloid cell nuclear differentiation ant 1857

101804 M86699 Hs 169840 TTK protein kinase 450

101809 M86849 Hs 323733 gap junction protein, beta 2, 26kD (conn 14000

101833 AU076442 Hs 117938 collagen, type XVII, alpha 1 256

101842 M93221 Hs 75182 mannose receptor, C type 1 1280

101851 BE260964 Hs 82045 midkine (neuπte growth-promoting factor 588

102002 NM.002484 Hs 81469 nucleotide binding protein 1 (E coli Mm 780

102039 AL134223 Hs 306098 aldo-keto reductase family 1, member C1 435

102072 U09410 Hs 78743 zinc finger protein 131 (clone pHZ-10) 740

102083 T35901 Hs 75117 interleukin enhancer binding factor 2, 4 5 12

102111 L36196 Hs 81884 sulfotraπsferase family, cytosolic, 2A, 1200

102123 NM 001809 Hs 1594 centromere protein A (17kD) 620

102154 U17760 Hs 75517 laminin, beta 3 (niceiπ (125kD), kalinm 262

102193 AL036335 Hs 313 secreted phosphoprotein 1 (osieopontin, 585

102217 AA829978 Hs 301613 JTV1 gene 6 18

102224 NM.002810 Hs 148495 proteasome (prosome, macropain) 26S subu 449

102234 AW163390 Hs 278554 heterochromatin-like protein 1 580

102251 NM 004398 Hs 41706 DEAD/H (Asp-GIu-Ala Asp/His) box polypep 50

102305 AL043202 Hs 90073 chromosome segregation 1 (yeast homolog) 5 15

102330 BE298063 Hs 77254 chromobox homolog 1 (Drosophila HP1 beta 417

102340 U37055 Hs 278657 macrophage stimulating 1 (hepatocyte gro 333

102348 U37519 Hs 87539 aldehyde dehydrogenase 3 family, member 887

102368 U39817 Hs 36820 Bloom syndrome 1591

102394 NM.00381& Hs 2442 a disintegrin and metalloproteinase doma 1920

102404 NM.005429 Hs 79141 vascular endothelial growth factor C 1400

102537 U57094 Hs 50477 RAB27A, member RAS oncogene family 1200

102581 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 457

102605 AI435128 Hs 181369 ubiquitm fusion degradation 1-lιke 3 98

102610 U65011 Hs 30743 preferentially expressed antigen in mela 7750

102623 AW249285 Hs 37110 melanoma antigen, family A, 9 1250

102642 AA205847 Hs 23016 G protein-coupled receptor 2200

102654 AV649989 Hs 24385 Human hbc647 mRNA sequence 1200

102659 BE245169 Hs 211610 CUG triplet repeat, RNA binding protein 1280

102669 U71207 Hs 29279 eyes absent (Drosophila) homolog 2 550

102672 U72066 Hs 29287 retinoblastoma-binding protein 8 J 50

102687 NM.007019 Hs 93002 ubiquitm carrier protein E2-C 9 24

102696 BE540274 Hs 239 forkhead box M1 554

102768 U82321 gb Homo sapiens clone 149B mRNA sequenc

102781 BE258778 Hs 108809 chaperonin containing TCP1, subunit 7 (e 378

102784 U85658 Hs 61796 transcπption factor AP-2 gamma (activat 426

102824 U90916 Hs 82845 Homo sapiens cDNA FLJ21930 fis clone H 1440

102829 NM 006183 Hs 80962 neurotens iOO

102888 AI346201 Hs 76118 ubiquitm carboxyl-termmal esterase L1 550

102892 BE440042 Hs 83326 matrix metalloproteinase 3 (stromelysin 670

102913 NM.002275 Hs 80342 keratin 15 464

102935 BE561850 Hs 80506 small nuclear ribonucleoprotein polypept 293

102951 X15218 Hs 2969 v-ski avian sarcoma viral oncogene homol 1140

102983 BE387202 Hs 118638 non-metastatic cells 1, protein (NM23A) 726

103023 AW500470 Hs 117950 multifunctional polypeptide similar to S 301

103036 M13509 Hs 83169 matπx metalloproteinase 1 (interstitial 2790

103038 AA926960 Hs 334883 CDC28 protein kinase 1 879

103060 NM.005940 Hs 155324 matrix metalloproteinase 11 (stromelysin 427

103099 AI693251 Hs 8248 NADH dehydrogenase (ubiquinone) Fe-S pro 380

103119 X63629 Hs 2877 cadheπn 3, type 1, P-cadhenn (placenta 405

103168 X53463 Hs 2704 glutathione peroxidase 2 (gastrointestm 307

103185 NM.006825 Hs 74368 transmembrane protein (63kD), endoplasmi 562

103192 M22440 Hs 170009 transforming growth factor, alpha 740

103223 BE275607 Hs 1708 chaperonin containing TCP1, subunit 3 (g 470

103242 X76342 Hs 389 alcohol dehydrogenase 7 (class IV), mu o 10000

103316 X83301 Hs 324728 SMA5 3 80

103375 NM 005982 Hs 54416 sine oculis homeobox (Drosophila) homolo 971

103376 AL036166 Hs 323378 coated vesicle membrane protein 1400

103385 NMJ307069 Hs 37189 similar to rat HREV107 11 00

103391 X94453 Hs 114366 pyrrolιne-5-carboxylate synthetase (glut 293

103404 BE394784 Hs 78596 proteasome (prosome, macropain) subunit, 5 15

103430 BE564090 Hs 20716 translocase of inner mitochondrial membr 3 98

103446 X98834 Hs 79971 sal (Drosophila) like 2 21 40

103476 Y07701 Hs 293007 ammopeptidase puromycm sensitive 1300

103477 AJ011812 Hs 119018 transcription factor NRF 540

103478 BE514982 Hs 38991 S100 calcium binding protein A2 502

103515 Y10275 Hs 56407 phosphosenne phosphatase 1050

103558 BE616547 Hs 2785 keratin 17 641

103580 AA328046 Hs 46405 polymerase (RNA) II (DNA directed) polyp 384

103587 BE270266 Hs 82128 5T4 oncofetal trophoblast glycoprotein 7850

103594 AI368680 Hs 816 SRY (sex determining region Y)-box 2 651

103636 NM 006235 Hs 2407 POU domain, class 2, associating factor 350

103768 AF086009 gb Homo sapiens full length insert cDNA 448

103841 AA314821 Hs 38178 hypothetical protein FLJ23468 800

103847 AF219946 Hs 102237 tubby super-family protein 1040

103913 AW967500 Hs 133543 ESTs 15 60

104094 AA418187 Hs 330515 ESTs 660 s. ypo e ca pro e n p .

104257 BE560621 Hs.9222 estrogen receptor binding site associate 6.80

104261 AW248364 Hs.5409 RNA polymerase I subunit

104331 AB040450 Hs.279862 cdk inhibitor p21 binding protein 6.80

104415 BE410992 Hs.258730 heme-regulated initiation factor 2-alpha 10.29

104558 R56678 Hs.88959 hypothetical protein MGC4816 4.21

104590 AW373062 Hs.83623 nuclear receptor subfamily 1, group 1, m 15.79

104658 AA360954 Hs.27268 Homo sapiens cDNA: FLJ21933 fis, clone H 17.40

104660 BE298665 Hs.14846 Homo sapiens mRNA; cDNA DKFZp564D016 (fr 6.40

104689 AA420450 Hs.292911 ESTs, Highly similar to S60712 band-6-pr 6.55

104754 AI206234 Hs.155924 cAMP responsive element modulator 10.00

104758 BE560269 Hs.7010 NPD002 protein 4.47

104971 BE311926 Hs.15830 hypothetical protein FLJ12691 2.87

105011 BE091926 Hs.16244 mitotic spindle coiled-coil related prot 3.83

105012 AF098158 Hs.9329 chromosome 20 open reading frame 1 2.86

105026 AA809485 Hs.124219 hypothetical protein FLJ12934 11.00

105076 AI598252 Hs.37810 hypothetical protein MGC14833 5.01

105132 AA148164 Hs.247280 HBV associated factor 3.99

105143 AI368836 Hs.24808 ESTs, Weakly similar to I38022 hypotheti 11.00

105158 AW976357 Hs.234545 hypothetical protein NUF2R 16.00

105175 AA305384 Hs.25740 ER01 (S. cerevisiae)-like 4.32

105200 AA328102 Hs.24641 cytoskeleton associated protein 2 3.00

105264 AA227934 gb:zr57e08.s1 Soares.NhHMPu.S1 Homo sapi 10.00

105298 BE387790 Hs.26369 hypothetical protein FLJ20287 3.69

105409 AW505076 Hs.301855 DiGeorge syndrome critical region gene 8 9.20

105460 AW296078 Hs.271721 Homo sapiens, clone IMAGE:4179986, mRNA, 7.80

105667 AA767526 Hs.22030 paired box gene 5 (B-cell lineage specif 4.12

105743 BE246502 Hs.9598 sema domain, immunoglobulin domain (Ig), 3.82

105782 H09748 Hs.57987 B-cell CLL/lymphoma 11 B (zinc finger pro 27.00

105848 AW954064 Hs.24951 ESTs 7.60

105891 U55984 Hs.289088 heat shock 90kD protein 1 , alpha 4.14

106019 AF221993 Hs.46743 McKusick-Kaufman syndrome 16.80

106069 BE566623 Hs.29899 ESTs, Weakly similar to G02075 transcrip 23.40

106073 AL157441 Hs.17834 downstream neighbor of SON 9.50

106126 AA576953 Hs.22972 hypothetical protein FLJ13352 6.00

106159 AK001301 Hs.3487 hypothetical protein FLJ10439 3.95

106220 D61329 Hs.32196 mitochondrial ribosomal protein L36 6.04

106260 AI097144 Hs.5250 ESTs, Weakly similar to ALU1.HUMAN ALU S 13.20

106300 Y10043 Hs.19114 high-mobility group (nonhistone chromoso 5.02

106307 AA436174 Hs.37751 ESTs, Weakly similar to putative p150 [ 6.60

106318 AA025610 Hs.9605 cleavage and polyadenylation specific fa 5.04

106341 AF191020 Hs.5243 hypothetical protein, estradiol-induced 7.25

106440 AA449563 Hs.151393 glulamate-cysteiπe ligase, catalytic sub 13.80

106481 D61594 Hs.17279 tyrosylprotein sulfotransferase 1 4.75

106586 AA243837 Hs.57787 ESTs 10.84

106605 AW772298 Hs.21103 Homo sapiens mRNA; cDNA DKFZp564B076 (fr 45.60

106654 AW075485 Hs.286049 phosphoserine aminotransferase 28.00

106785 Y15227 Hs.20149 deleted in ly phocytic leukemia, 1 3.00

106813 C05766 Hs.181022 CGI-07 protein 11.40

106895 AK001826 Hs.25245 hypothetical protein FLJ11269 6.00

106913 AI219346 Hs.86178 M-phase phosphopratein 9 6.56

106919 AW043637 Hs.21766 ESTs, Weakly similar to ALU5 HUMAN ALU S 4.27

107054 AI076459 Hs.15978 KIAA1272 protein 34.80

107059 BE614410 Hs.23044 RAD51 (S. cerevisiae) homolog (E coli Re 4.71

107098 AI823593 Hs.27688 ESTs 24.80

107104 AU076640 Hs.15243 nucleolar protein 1 (120kD) 7.05

107129 AC004770 Hs.4756 flap structure-specific endonuclease 1 2.60

107198 AV657225 Hs.9846 KIAA1040 protein 19.20

107203 D20426 Hs.41639 programmed cell death 2 7.60

107217 AL080235 Hs.35861 DKFZP586E1621 protein 9.50

107284 NM 005629 Hs.187958 solute carrier family 6 (neurotransmitte 2.71

107318 T74445 Hs.5957 Homo sapiens clone 24416 mRNA sequence 8.71

107516 X57152 Hs.99853 fibrillarin 4.33

107529 BE515065 Hs.296585 nucleolar protein (KKE/D repeat) 4.00

107728 AA019551 Hs.294151 Homo sapiens, clone IMAGE:3603836, mRNA, 10.80

107851 AA022953 Hs.61172 EST 8.00

107901 L42612 Hs.335952 keratin 6B 3.40

107922 BE153855 Hs.61460 Ig superfamily receptor LNIR 2.88

107932 AW392555 Hs.18878 hypothetical protein FLJ21620 7.50

108015 AW298357 Hs.49927 protein kinase NY D-SP15 23.40

108056 AA043675 Hs.62633 ESTs 12.80

^■108075 AI867370 Hs.139709 hypothetical protein FLJ 12572 12.80

108187 BE245374 Hs.27842 hypothetical protein FLJ11210 7.00

108296 N31256 Hs.161623 ESTs 6.60

108305 AA071391 gb:zm61e06.r1 Stratagene fibroblast (937 11.80

108393 AA075211 gb:zm86a08.r1 Stratagene ovarian cancer 11.80

108480 AL133092 Hs.68055 hypothetical protein DKFZp434l0428 20.80

108554 AA084948 gb:zn13b09.s1 Stratagene hNT neuron (937 6.40

108573 AA086005 gb:zl84c04.s1 Stratagene colon (937204) 25.40

108584 AA088326 Hs.120905 Homo sapiens cDNA FLJ11448 fis, clone HE 9.60

108597 AK000292 Hs.278732 hypothetical protein FU20285 14.60

108695 AB029000 Hs.70823 KIAA1077 protein 3.00

108699 AA121514 Hs.70832 ESTs 10.00

108700 AA121518 Hs.193540 ESTs, Moderately similar to 2109260A B c 11.00

108780 AU076442 Hs.117938 collagen, type XVII, alpha 1 11.21 108810 AW295647 Hs.71331 hypothetical protein MGC5350 8.50

108816 AA130884 Hs.270501 ESTs, Moderately similar to ALU2.HUMAN 7.40

108857 AK001468 Hs.62180 anillin (Drosophila Scraps homolog), act 4.00

108860 AA133334 Hs.129911 ESTs 6.09

108937 AL050107 Hs.24341 transcriptional co-activator with PDZ-bi 3.00

109010 NM 007240 Hs.44229 dual specificity phosphatase 12 2.69

109121 BE389387 Hs.49767 NADH dehydrogenase (ubiquinone) Fe-S pro 4.53

109166 AA219691 Hs.73625 RAB6 interacting, kinesin-like (rabkines 10.58

109227 AA766998 Hs.85874 Human DNA sequence from clone RP11-16L21 9.00

109415 U80736 Hs.110826 trinucleotide repeat containing 9 51.40

109418 AI866946 Hs.161707 ESTs 11.00

109454 AA232255 Hs.295232 ESTs, Moderately similar to A46010 X-li 17.60

109502 AW967069 Hs.211556 hypothetical protein MGC5487 9.49

109543 AA564994 Hs.222851 ESTs 12.67

109648 H17800 Hs.7154 ESTs 10.40

109680 AB037734 Hs.4993 KIAA1313 protein 33.20

109700 F09609 gb:HSC33H092 normalized infant brain cDN 16.00

109704 AI743880 Hs.12876 ESTs 11.00

109792 R49625 gb:yg61f03.s1 Soares infant brain 1NIB H 12.60

109981 BE546208 Hs.26090 hypothetical protein FLJ20272 4.00

109998 AL042201 Hs.21273 transcription factor NYD-sp10 7.80

110039 H11938 Hs.21907 histone acetyltransferase 7.00

110156 AA581322 Hs.4213 hypothetical protein MGC16207 4.24

110500 AA907723 Hs.36962 ESTs 4.50

110551 AW450381 Hs.14529 ESTs 8.60

110561 AA379597 Hs.5199 HSPC150 protein similar lo ubiquilin-con 3.06

110854 BE612992 Hs.27931 hypothetical protein FLJ10607 similar to 6.80

110886 AW274992 Hs.72249 three-PDZ containing protein similar to 8.80

110916 BE178102 Hs.24349 ESTs 6.80

111003 N52980 Hs.83765 dihydrofolate reductase 16.80

111337 AA837396 Hs.263925 LIS1-interacting protein NUDE1, rat homo 2.54

111434 R01608 Hs.142736 ESTs 9.80

111439 AI476429 Hs.19238 ESTs 10.40

111540 U82670 Hs.9786 zinc finger protein 275 15.40

111597 R11499 Hs.189716 ESTs 9.20

111895 T80581 Hs.12723 Homo sapiens clone 25153 mRNA sequence 6.80

111929 AF027208 Hs.112360 promiπin (mouse)-like 1 14.67

112054 R43590 gb:yc85g02.s1 Soares infant brain 1NIB H 10.80

112210 R49645 Hs.7004 ESTs 10.20

112244 AB029000 Hs.70823 KIAA1077 protein 2.99

112382 R59904 gb:yh07g12.s1 Soares infant brain 1NIB H 6.60

112392 R60763 Hs.193274 ESTs, Moderately similar to I57588 HSrel 7.10

112442 AA280174 Hs.285681 Williams-Beuren syndrome chromosome regi 3.00

112539 R70318 Hs.339730 ESTs 37.20

112772 AI992283 Hs.35437 ESTs, Moderately similar to I38026 MLN 6 14.60

112869 BE261750 Hs.4747 dyskeratosis coπgenita 1, dyskerin 4.83

112935 R71449 Hs.268760 ESTs 2.73

112970 AA694010 Hs.6932 Homo sapiens clone 23809 mRNA sequence 12.00

112973 AB033023 Hs.318127 hypothetical protein FLJ10201 11.50

112992 AL157425 Hs.133315 Homo sapiens mRNA; cDNA DKFZp761J1324 (f 10.89

113063 W15573 Hs.5027 ESTs, Weakly similar to A47582 B-cell gr 15.00

113073 N39342 Hs.103042 microtubule-associated protein 1B 15.31

113078 T40444 Hs.118354 CAT56 protein 7.00

113238 R45467 Hs.189813 ESTs 41.20

113591 T91881 Hs.200597 KIAA0563 gene product 9.40

113702 T97307 gb:ye53h05.s1 Soares fetal liver spleen 25.00

113844 AI369275 Hs.243010 Homo sapiens cDNA FLJ14445 fis, clone HE 13.91

113984 R96696 Hs.35598 ESTs 7.80

114073 R44953 Hs.22908 Homo sapiens mRNA; cDNA DKFZp434J1027 (f 7.20

114162 AF155661 Hs.22265 pyruvate dehydrogenase phosphatase 3.42

114208 AL049466 Hs.7859 ESTs 6.74

114251 H15261 Hs.21948 ESTs 33.20

114285 R44338 Hs.22974 ESTs 13.20

114313 H18456 Hs.27946 ESTs 10.00

114339 AA782845 Hs.22790 ESTs 7.80

114407 BE539976 Hs.103305 Homo sapiens mRNA; cDNA DKFZp434B0425 (f 4.14

114560 AI452469 Hs.165221 ESTs 9.80

114699 AA127386 gb:zn90d09.r1 Stratagene lung carcinoma 7.60

114767 AI859865 Hs.154443 minichromosome maintenance deficient (S 3.21

114793 AA158245 gb:zo76c03.s1 Stratagene pancreas (93720 6.00

114833 AI417215 Hs.87159 hypothetical protein FU 12577 11.40

115047 BE270930 Hs.82916 chaperonin containing TCP1, subunit 6A ( 4.31

115060 AF052693 Hs.198249 gap junction protein, beta 5 (connexin 3 4.03

115097 AA256213 Hs.72010 ESTs 35.40

115113 AA256460 gb:zr81a04.s1 Soares.NhHMPu.S1 Homo sapi 15.20

115123 AA256641 Hs.236894 ESTs, Highly similar to S02392 alpha-2-m 4.19

115134 AW968073 Hs.194331 ESTs, Highly similar to A55713 inositol 12.40

115291 BE545072 Hs.122579 hypothetical protein FU10461 25.00

115347 AA356792 Hs.334824 hypothetical protein FU14825 7.00

115414 AA662240 Hs.283099 AF15q14 protein 3.25

115522 BE614387 Hs.333893 c-Myc target JP01 3.68

115536 AK001468 Hs.62180 anillin (Drosophila Scraps homolog), act 10.50

115566 AI142336 Hs.43977 Human DNA sequence from clone RP11-196N1 24.40

115645 AI207410 Hs.69280 Homo sapiens, clone IMAGE:3636299, mRNA, 4.17

115648 AW016811 Hs.234478 Homo sapiens cDNA: FLJ22648 fis, clone H 6.00 115652 BE093589 Hs.38178 hypothetical protein FLJ23468 3.81

115697 D31382 Hs.63325 transmembrane protease, seriπe 4 62.14

115793 AA424883 Hs.70333 hypothetical protein MGC10753 11.80

115816 BE042915 Hs.287588 Homo sapiens cDNA FLJ13675 fis, clone PL 9.71

115892 AA291377 Hs.50831 ESTs 27.40

115906 AI767756 Hs.82302 Homo sapiens cDNA FLJ14814 fis, clone NT 2.53

115909 AW872527 Hs.59761 ESTs, Weakly similar to DAP1.HUMAN DEATH 11.82

115965 AA001732 Hs.173233 hypothetical protein FLJ10970 34.29

115978 AL035864 Hs.69517 cDNA for differentially expressed C016 g 8.23

115985 AA447709 Hs.268115 ESTs, Weakly similar to T08599 probable 3.00

116090 AI591147 Hs.61232 ESTs 5.17

116096 AA682382 Hs.59982 ESTs 8.20

116127 AF126743 Hs.279884 DNAJ domain-containing 10.60

116157 BE439838 Hs.44298 mitochondrial ribosomal protein S17 5.82

116190 AI949095 Hs.67776 ESTs, Weakly similar to T22341 hypotheti 4.08

116278 NM.003686 Hs.47504 exonuclease 1 9.50

116335 AK001100 Hs.41690 desmocollin 3 3.67

116496 AW450694 Hs.21433 hypothetical protein DKFZp547J036 7.00

116503 AI925316 Hs.212617 ESTs 12.60

116674 AI768015 Hs.92127 ESTs 32.00

116929 AA586922 Hs.80475 polymerase (RNA) II (DNA directed) polyp 7.60

116973 AI702054 Hs.166982 phosphatidylinositol glycan, class F 9.80

116993 AI417023 Hs.40478 ESTs 10.20

117079 H92325 gb:ys85f05.s1 Soares retina N2b4HR Homo 15.20

117317 AI263517 Hs.43322 ESTs 13.40

117326 N23629 Hs.241420 Homo sapiens mRNA for KIAA1756 protein, 20.60

117396 W20128 Hs.296039 ESTs 10.60

117412 N32536 Hs.42645 ESTs 16.00

117519 N32528 Hs.146286 kinesin family member 13A 9.11

117693 AW179019 Hs.112110 mitochondrial ribosomal protein L42 4.01

117721 N46100 Hs.93939 EST 19.80

117881 AF161470 Hs.260622 butyrate-induced transcript 1 2.71

117903 AA768283 Hs.47111 ESTs 17.80

117992 AI015709 Hs.172089 Homo sapiens mRNA; cDNA DKFZp586l2022 (f 4.17

118013 AI674126 Hs.94031 ESTs 10.60

118017 AI813444 Hs.42197 ESTs 8.82

118186 N22886 Hs.42380 ESTs 7.00

118325 AI868065 Hs.166184 intersectin 2 13.80

118367 N64269 Hs.48946 EST 6.14

118368 N64339 Hs.48956 gap junction protein, beta 6 (connexin 3 3.14

118472 AL157545 Hs.42179 bromodomain and PHD finger containing, 3 12.40

118709 AA232970 Hs.293774 ESTs 12.20

119025 BE003760 Hs.55209 Homo sapiens mRNA; cDNA DKFZp434K0514 (f 4.50

119027 AF086161 Hs.114611 hypothetical protein FLJ11808 3.22

119052 R10889 gb:yf38d02.s1 Soares fetal liver spleen 9.60

119164 AF221993 Hs.46743 McKusick-Kaufman syndrome 6.60

119186 AI979147 Hs.101265 hypothetical protein FLJ22593 10.80

119243 T12603 gb:CHR90123 Chromosome 9 exon II Homo sa 9.44

119490 AA195276 Hs.263858 ESTs, Moderately similar to B34087 hypot 11.80

119499 AI918906 Hs.55080 ESTs 14.80

119599 W45552 gb:zc26d03.s1 Soares.seπescen fihroblas 12.60

119780 NM.016625 Hs.191381 hypothetical protein 17.00

119845 W79123 Hs.58561 G protein-coupled receptor 87 13.50

119941 AA699485 Hs.58896 ESTs 8.00

119994 AA642402 Hs.59142 ESTs 7.73

120102 W67353 Hs.170218 KIAA0251 protein 39.60

120104 AK000123 Hs.180479 hypothetical protein FLJ20116 2.91

120294 AK000059 Hs.153881 Homo sapiens NY-REN-62 antigen mRNA, par 8.20

120486 AW368377 Hs.137569 tumor protein 63 kDa with strong homolog 8.73

120599 AA804448 Hs.104463 ESTs 7.00

120699 AI683243 Hs.97258 ESTs, Moderately similar to S29539 ribos 10.00

120715 AA292700 gb:zs59a06.s1 NCI.CGAP.GCB1 Homo sapiens 9.40

120821 Y19062 Hs.96870 staufen (Drosophila, RNA-bindiπg protein 13.80

120859 AA826434 Hs.1619 achaete-scute complex (Drosophila) homol 9.00

120880 AA360240 Hs.97019 EST 15.60

120983 AA398209 Hs.97587 EST 27.66

121034 AL389951 Hs.271623 nucleoporin 50kD 20.80

121121 AA399371 Hs.189095 similar to SALL1 (sal (Drosophila)-like 22.80

121313 AA402713 Hs.97872 ESTs 10.00

121369 AW450737 Hs.128791 CGI-09 protein 25.71

121376 AA448103 Hs.187958 solute carrier family 6 (neurotransmitte 5.42

121476 AA412311 Hs.97903 ESTs 8.30

121509 AA868939 Hs.97888 ESTs 8.59

121553 AA412488 Hs.48820 TATA box binding protein (TBP)-associat 18.50

121753 AK000552 Hs.323518 WD repeat domain 5 7.00

121838 AA425680 Hs.98441- ESTs 10.40

121857 BE387162 Hs.280858 ESTs, Highly similar to A35661 DNA excis 6.00

121991 AA430058 Hs.98649 EST 12.20

122089 AW016543 Hs.98682 hypothetical protein FKSG32 8.60

122105 AW241685 Hs.98699 ESTs 6.14

122163 AA435702 Hs.98829 EST 10.40

122318 AA429743 gb:zv60b05.r1 Soares.testis.NHT Homo sap 18.20

122335 AA443258 Hs.241551 chloride channel, calcium activated, fam 13.50

122338 AA443311 Hs.98998 ESTs 4.80

122414 AI313473 Hs.99087 ESTs, Weakly similar to S47073 finger pr 3.00 122512 AF053305 Hs.98658 budding uninhibited by benzimidazoles 1 8.80

122516 AA449352 Hs.99217 ESTs 9.40

122702 AI220089 Hs.99439 ESTs 9.20

122852 AI580056 Hs.98992 ESTs 10.40

122925 AW268962 Hs.111335 ESTs 6.80

123005 AW369771 Hs.52620 integrin, beta 8 12.60

123044 AK001035 Hs.130881 B-cell CLL/lymphoma 11 A (zinc finger pro 5.35

123160 AA488687 Hs.284235 ESTs, Weakly similar to I38022 hypotheti 6.06

123315 AA496369 gb:zv37d10.s1 Soares ovary tumor NbHOT H 12.40

123329 Z47542 Hs.179312 small nuclear RNA activating complex, po 11.80

123497 AA765256 Hs.135191 ESTs, Weakly similar to unnamed protein 12.00

123518 AL035414 Hs.21068 hypothetical protein 13.00

123519 AW015887 Hs.112574 ESTs 12.20

123614 AK000492 Hs.98806 hypothetical protein 7.80

123616 AA680003 Hs.109363 Homo sapiens cDNA: FLJ23603 fis, clone L 10.60

123673 BE550112 Hs.158549 ESTs, Weakly similar to T2D3.HUMAN TRANS 23.00

123727 AI083986 Hs.282977 hypothetical protein FLJ13490 7.00

123731 AA609839 gb:ae62f01.s1 Stratagene lung carcinoma 9.80

123752 AA227714 Hs.179703 KIAA0129 gene product 3.50

123900 AA621223 Hs.112953 EST 12.80

124006 AI147155 Hs.270016 ESTs 97.00

124059 BE387335 Hs.283713 ESTs, Weakly similar to S64054 hypotheti 3.02

124069 AF134160 Hs.7327 claudin 1 27.80

124191 T96509 Hs.248549 ESTs, Moderately similar to S65657 alpha 35.80

124273 AA457211 Hs.8858 bromodomain adjacent to zinc finger doma 7.20

124297 AL080215 Hs.102301 Homo sapiens mRNA; cDNA DKFZp586J0323 (f 11.00

124305 AW963221 gb:EST375294 MAGE resequences, MAGH Homo 16.00

124676 AI360119.compHs.181013 phosphoglycerate mutase 1 (brain)

124874 BE550182 Hs.127826 RalGEF-like protein 3, mouse homolog 21.00

124904 AK000483 Hs.93872 KIAA1682 protein 9.40

124969 AI650360 Hs.100256 ESTs 10.80

125000 T58615 Hs.110640 ESTs 9.80

125201 AA693960 Hs.103158 ESTs, Weakly similar to T33296 hypotheti 7.60

125266 W90022 Hs.186809 ESTs, Highly similar to LCT2 HUMAN LEUKO 6.59

125299 T32982 Hs.102720 ESTs 9.57

125356 AI057052 Hs.133554 ESTs, Weakly similar to Z195.HUMAN ZINC 14.00

125370 AA256743 Hs.134158 Homo sapiens, Similar to KIAA0092 gene p 8.20

125418 AA777690 Hs.188501 ESTs 13.20

125433 AL162066 Hs.54320 hypothetical protein DKFZp762D096 21.40

125437 AI609449 Hs.140197 ESTs 6.96

125446 BE219987 Hs.166982 phosphatidylinositol glycan, class F 8.80

125711 AA305800 Hs.5672 hypothetical protein AF140225 11.20

125756 BE174587 Hs.289721 growth arrest specific transcript 5 4.31

125757 AI274906 Hs.166835 ESTs, Highly similar to 1814460A p53-ass 15.60

125769 BE270266 Hs.82128 5T4 oncofetal trophoblast glycoprotein 3.20

125839 AW836261 Hs.337717 ESTs 8.20

125850 W85858 Hs.99804 ESTs 2.65

125875 H14480 gb:ym18b09.r1 Soares infant brain 1NIB H 7.40

125924 BE272506 Hs.82109 syndecan 1 4.23

125972 AI927475 Hs.35406 ESTs, Highly similar to unnamed protein 3.98

126034 H60340 gb:yr39b04.r1 Soares fetal liver spleen 10.60

126327 AA432266 Hs.44648 ESTs 11.60

126345 N49713 gb:yv23f06.s1 Soares fetal liver spleen 6.67

126435 AW614529 Hs.285847 CGI-19 protein 10.60

126487 AA283809 Hs.184601 solute carrier family 7 (cationic amino

126521 AI475110 Hs.203933 ESTs 6.60

126522 W31912 gb:zc76d03.s1 Pancreatic Islet Homo sapi 14.80

126543 AL035864 Hs.69517 cDNA for differentially expressed C016 g 4.01

126567 AA058394 Hs.57887 ESTs, Weakly similar to KIAA0758 protein 7.80

126605 AA676910 gb:zj65h07.si Soares.fetaljiver.spleen. 11.60

126627 AA497044 Hs.20887 hypothetical protein FLJ10392 14.60

126628 N49776 Hs.170994 hypothetical protein MGC10946 8.00

126737 AW976516 Hs.283707 Homo sapiens cDNA: FLJ21354fis, clone C 2.92

126795 AW975076 Hs.172589 nuclear phosphoprotein similar to S. cer 7.50

126802 AW805510 Hs.97056 hypothetical protein FLJ21634 11.60

126892 AF121856 Hs.284291 sorting nexin 6 3.50

126928 AA480902 Hs.137401 ESTs 22.83

126979 AA210954 gb:zq89h10.r1 Stratagene hNT neuron (937 11.80

126986 AI279892 Hs.46801 sorting nexin 14 11.60

126992 AI809521 gb:wf30e03.x1 Soares.NFLT_GBC.S1 Homo s 20.80

127066 R25066 gb:yg42c07.r1 Soares infant brain 1NIB H 27.60

127099 AA347668 gb:EST54026 Fetal heart II Homo sapiens 21.60

127139 AA830233 Hs.293585 ESTs 11.20

127209 AA305023 Hs.81964 SEC24 (S. cerevisiae) related gene famil 3.10

127221 BE062109 Hs.241551 chloride channel, calcium activated, fam 2.76

127225 AA315933 Hs.120879 ESTs 16.80

127313 AK002014 Hs.47546 Homo sapiens cDNA FLJ11458 fis, clone HE 14.00

127444 AW978474 Hs.7560 Homo sapiens mRNA for KIAA1729 protein, 13.60

127500 AW971353 Hs.162115 ESTs 11.20

127524 AI243596 Hs.94830 ESTs, Moderately similar to T03094 A-kin 7.80

127540 N45572 Hs.105362 Homo sapiens, clone MGG18257, mRNA, com 3.53

127599 AA613204 Hs.150399 ESTs 13.80

127609 X80031 Hs.530 collagen, type IV, alpha 3 (Goodpasture 28.00

127662 W80755 Hs.8294 KIAA0196 gene product 19.80

127668 AI343257 Hs.139993 ESTs 11.20 127746 AI239495 Hs 120189 ESTs 1418

127812 AA741368 Hs 291434 ESTs 450

127817 AA836641 Hs 163085 ESTs 2460

127959 AI302471 Hs 124292 Homo sapiens cDNA FLJ231 3 fis, clone L 920

127960 AI613226 Hs 41569 phosphatidic acid phosphatase type 2A 1683

127969 F06498 Hs 93748 Homo sapiens cDNA FLJ14676 fis, clone NT 1360

128015 Z21169 Hs 334659 hypothetical protein MGC14139 700

128027 AI433721 Hs 164153 ESTs 3740

128077 AI310330 Hs 128720 ESTs 960

128166 NM 006147 Hs 11801 interferon regulatory factor 6 924

128226 AI284940 Hs 289082 GM2 ganglioside activator protein 1900

128305 AI954968 Hs 279009 matrix Gla protein 1040

128341 AA191420 Hs 185030 ESTs 900

128527 AA504583 Hs 101047 transcription factor 3 (E2A immunoglobul 430

128539 R46163 Hs 258618 ESTs 1260

128568 H12912 Hs 274691 adenylate kinase 3 456

128572 AA933022 Hs 256583 interleukin enhancer binding factor 3, 9 1000

128777 AI878918 Hs 10526 cysteme and glycme-πch protein 2 1680

128781 N71826 Hs 105465 small nuclear πbonucleoprotein polypept 448

128796 AJ000152 Hs 105924 defensm, beta 2 812

128920 AA622037 Hs 166468 programmed cell death 5 462

128924 BE279383 Hs 26557 plakophilm 3 404

128971 H05132 Hs 107510 ESTs 1260

129008 AL079648 Hs 301088 ESTs 880

129041 BE382756 Hs 169902 solute earner family 2 (facilitated glu 605

129075 BE250162 Hs 83765 dihydrofolate reductase 259

129105 AI769160 Hs 108681 Homo sapiens brain tumor associated prot 667

129189 AB023179 Hs 9059 KIAA0962 protein 800

129229 AF013758 Hs 109643 polyadenylate binding protem-interactin 400

129241 AI878857 Hs 109706 hematological and neurological expressed 406

129300 W94197 Hs 110165 ribosomal protein L26 homolog 255

129404 AI267700 Hs 317584 ESTs 1800

129457 X61959 Hs 207776 aspartylglucosaminidase 650

129466 L42583 Hs 334309 keratin 6A 1294

129494 AI148976 Hs 112062 ESTs 11 00

129605 AF061812 Hs 115947 keratin 16 (focal non-epidermolytic palm 446

129641 AI911527 Hs 11805 ESTs 1200

129665 AW163331 Hs 118778 KDEL (Lys-Asp-Glu-Leu) endoplasmic retic 470

129703 BE388665 Hs 179999 Homo sapiens, clone IMAGE 3457003, mRNA 402

129720 AA156214 Hs 12152 APMCF1 protein 571

129748 M16707 Hs 123053 H4 histone, family 2 350

129890 AI868872 Hs 282804 hypothetical protein FLJ22704 421

129896 BE295568 Hs 13225 UDP-Gal betaGlcNAc beta 1 ,4- galactosylt 256

129945 BE514376 Hs 165998 PAI-1 mRNA binding protein 403

130010 AA301116 Hs 142838 nucleolar phosphoprotein Nopp34 700

130026 T40480 Hs 332112 EST 640

130080 X14850 Hs 147097 H2A histone family, member X 465

130149 AW067805 Hs 172665 methylenetetrahydrofolate dehydrogenase 274

130285 AA063546 Hs 75981 ubiquitm specific protease 14 (tRNA-gua 740

130441 U63630 Hs 155637 protein kinase, DNA-activated, catalytic 391

130482 AW409701 Hs 1578 baculoviral IAP repeat containing 5 (sur 487

130500 AB007913 Hs 158291 KIAA0444 protein 960

130524 U89995 Hs 159234 forkhead box E1 (thyroid transcπption f 1340

130541 X05608 Hs 211584 neurofilament, light polypeptide (68kD) 820

130553 AF062649 Hs 252587 pituitary tumor-transforming 1 606

130567 AA383092 Hs 1608 replication protein A3 (14kD) 700

130577 M69241 Hs 162 insulin like growth factor binding prate 304

130627 BE003054 Hs 1695 matrix metalloproteinase 12 (macrophage 387

130648 AI458165 Hs 17296 hypothetical protein MGC2376 1620

130697 L29472 Hs 1802 major histocompatibility complex, class 1780

130744 H59696 Hs 18747 POP7 (processing of precursor, S cerevi 528

130800 AI187292 Hs 19574 hypothetical protein MGC5469 443

130867 NM 001072 Hs 284239 UDP glycosyltransferase 1 family, polype 1684

130869 J03626 Hs 2057 undine monophosphate synthetase (orotat 492

130925 AF093419 Hs 169378 multiple PDZ domain protein 960

130994 W17044 Hs 327337 ESTs 1240

131028 AI879165 Hs 2227 CCAAT/enhaπcer binding protein (C/EBP), 1021

131031 NM 001650 Hs 288650 aquaponn 4 980

131041 T15767 Hs 22452 Homo sapiens mRNA for KIAA1737 protein, 960

131058 W28545 Hs 101514 hypothetical protein FLJ 10342 1700

131090 A1143139 Hs 2288 visinm-like 1 274

131112 H15302 Hs 168950 Homo sapiens mRNA, cDNA DKFZp566A1046 (f 880

131148 AW953575 Hs 303125 p53 induced protein PIGPC1 312

131185 BE280074 Hs 23960 cyclm B1 307

131200 BE540516 Hs 293732 hypothetical protein MGC3195 307

131219 W25005 Hs 24395 small inducible cytokine subfamily B (Cy 287

131257 AW339037 Hs 24908 ESTs 1467

131375 AW293165 Hs 143134 ESTs 1920

131460 NM.003729 Hs 27076 RNA 3'-termιnal phosphate cyclase 350

131476 AI521663 Hs 334644 hypothetical protein FLJ 14668 1500

131510 BE245374 Hs 27842 hypothetical protein FLJ11210 780

131646 BE302464 Hs 30057 MRS2 (S cerevιsιae)-lιke, magnesium horn 700

131786 BE000971 Hs 306083 Novel human gene mapping to chomosome 22 265

131839 AB014533 Hs 33010 KIAA0633 protein 3520

131843 AA192315 Hs 184062 putative Rab5-ιnteractmg protem 411 131877 J04088 Hs.156346 topoisomerase (DNA) II alpha (170kD) 19.00

131885 BE502341 Hs.3402 ESTs 6.48

131921 AA456093 Hs.34720 ESTs 8.40

131945 NM 002916 Hs.35120 replication factor C (activator 1) 4 (37 56.00

131958 NM.014062 Hs.3566 ART-4 protein 3.82

131965 W79283 Hs.35962 ESTs 3.03

132000 AW247017 Hs.36978 melanoma antigen, family A, 3 9.80

132040 NM 001196 Hs.315689 Homo sapiens cDNA: FLJ22373 As, clone H 3.30

132109 AW190902 Hs.40098 cysteine knot superfamily 1 , BMP antagon 21.00

132114 NM.006152 Hs.40202 lymphoid-restricted membrane protein 8.40

132162 AA315805 Hs.94560 desmoglein 2 12.25

132164 AI752235 Hs.41270 procollageπ-lysine, 2-oxoglutarate 5-dio 2.70

132180 NM 004460 Hs.418 fibroblast activation protein, alpha 2.71

132181 AW961231 Hs.16773 Homo sapiens clone TCCCIA00427 mRNA sequ 3.83

132182 NM.014210 Hs.70499 ecotropic viral integration site 2A 13.20

132231 AA662910 Hs.42635 hypothetical protein DKFZp434K2435 9.50

132277 AK001745 Hs.184628 hypothetical protein FLJ 10883 4.50

132328 NM 014787 Hs.44896 DnaJ (Hsp40) homolog, subfamily B, membe 9.20

132394 AK001680 Hs.30488 DKFZP434F091 protein 19.80

132424 AA417878 Hs.48401 ESTs, Moderately similar to ALU8.HUMAN A 8.60

132528 T78736 Hs.50758 SMC4 (structural maintenance of chromoso 27.40

132543 BE568452 Hs.5101 protein regulator of cytokinesis 1 4.38

132544 L19778 Hs.51011 H2A histone family, member P 7.00

132550 AW969253 Hs.170195 bone morphogenetic protein 7 (osteogenic 2.64

132552 BE621985 Hs.296922 thiopurine S-methyltransferase 15.83

132581 AK000631 Hs.52256 hypothetical protein FLJ20624 5.60

132617 AF037335 Hs.5338 carbonic anhydrase XII 4.95

132638 AI796870 Hs.54277 DNA segment on chromosome X (unique) 992 8.20

132653 Z15008 Hs.54451 laminin, gamma 2 (nicein (lOOkD), kalini 4.38

132669 W38586 Hs.293981 guanine nucleotide binding protein (G pr 4.36

132710 W74001 Hs.55279 serine (or cysteine) proteinase inhibito 4.60

132771 Y10275 Hs.56407 phosphoserine phosphatase 3.71

132799 W73311 Hs.169407 SAC2 (suppressor of actin mutations 2, 9.48

132833 U78525 Hs.57783 eukaryotic translation initiation factor 5.83

132892 AW834050 Hs.9973 tensin 12.00

132906 BE613337 Hs.234896 geminin 3.09

132959 AW014195 Hs.61472 ESTs, Weakly similar to YAE6.YEAST HYPOT 3.87

132962 AA576635 Hs.6153 CGI-48 protein 3.50

132990 X77343 Hs.334334 transcription factor AP-2 alpha (activat 6.18

132994 AA112748 Hs.279905 clone HQ0310 PRO0310p1 3.19

133000 AL042444 Hs.62402 p21/Cdc42/Rac1-activated kinase 1 (yeast 2.96

133050 X73424 Hs.63788 propionyl Coenzyme A carboxylase, beta p 2.55

133083 BE244588 Hs.6456 chaperonin containing TCP1, subunit 2 (b 4.00

133086 L17131 Hs.139800 high-mobility group (nonhistone chromoso

133134 AF198620 Hs.65648 RNA binding motif protein 8A

133155 M58583 Hs.662 cerebellin 1 precursor 10.80

133181 X91662 Hs.66744 twist (Drosophila) homolog (acrocephalos 3.00

133204 BE267696 Hs.254105 enolase l, (alpha) 4.63

133412 U41493 Hs.73112 guanine nucleotide binding protein (G pr 12.50

133421 AF134160 Hs.7327 claudin 1 2.85

133451 AW970026 Hs.73818 ubiquinol-cytochrome c reductase hinge p 4.66

133453 AI659306 Hs.73826 protein tyrosine phosphatase, non-recept 6.80

133504 NM 004415 Hs.74316 desmoplakin (DPI, DPII) 6.14

133506 BE562958 Hs.74346 hypothetical protein MGC14353 4.55

133615 M62843 Hs.75236 ELAV (embryonic lethal, abnormal vision, 17.80

133627 NM 002047 Hs.75280 glycyl-tRNA synthetase 4.85

133649 U25849 Hs.75393 acid phosphatase 1, soluble 6.34

133669 NM.006925 Hs.166975 splicing factor, arginine/serine-rich 5 14.00

133749 L20852 Hs.10018 solute carrier family 20 (phosphate tran 6.11

133776 BE268649 Hs.177766 ADP-ribosyltransferase (NAD+; poly (ADP- 4.91

133865 AB011155 Hs.170290 discs, large (Drosophila) homolog 5 3.07

133946 AJ001258 Hs.173878 NIPSNAP, C. elegans, homolog 1 4.60

133973 N55540 Hs.78026 ESTs, Weakly similar to similar to ankyr 13.00

134047 BE262529 Hs.78771 phosphoglycerate kinase 1 3.85

134098 BE513171 Hs.79086 mitochondrial ribosomal protein L3 2.56

134107 NM 005629 Hs.187958 solute carrier family 6 (πeurotransmitte 8.20

134112 AW449809 Hs.79150 chaperonin containing TCP1 , subunit 4 (d 4.08

134158 U15174 Hs.79428 BCL2/adenovirus E1B 19kD-interacting pro 31.00

134160 T98152 Hs.79432 fibrillin 2 (congenital contraotural ara 24.60

134168 AA398908 Hs.181634 Homo sapiens cDNA: FLJ23602 fis, clone L

134185 AA285136 Hs.301914 neuronal specific transcription factor D 14.74

134201 L35035 Hs.79886 ribose 5-phosphate isomerase A (ribose 5 J.40

134272 X76040 Hs.278614 protease, serine, 15 4.50

134276 BE083936 Hs.80976 antigen identified by monoclonal anlibod 9.00

134353 AL138201 Hs.82120 nuclear receptor subfamily 4, group A, m 16.40

134367 AA339449 Hs.82285 phosphoribosylglycinamideformyltransfer 2.80

134380 AU077143 Hs.179565 minichromosome maintenance deficient (S. 4.68

134423 H53497 Hs.83006 CG1-139 protein 3.84

134469 AA279661 Hs.83753 small nuclear ribonucleoprotein polypept 5.81

134470 X54942 Hs.83758 CDC28 protein kinase 2 4.21

134498 AW246273 Hs.84131 threonyl-tRNA synthetase 7.30

134502 BE148534 Hs.84168 UV-B repressed sequence, HUR 7 13.60

134510 NM.002757 Hs.250870 mitogeπ-activated protein kinase kinase 9.70

134548 N95406 Hs.333495 Deleted in split-hand/split-foot 1 regio 4.63

134654 AK001741 Hs.8739 hypothetical protein FLJ 10879 6.00 134724 AF045239 Hs.321576 ring finger protein 22 12.00

134743 AA044163 Hs.89463 potassium large conductance calcium-acti 4.00

134781 AA374372 Hs.89626 parathyroid hormone-like hormone 25.20

134806 AD001528 Hs.89718 spermine synthase 4.58

134853 BE268326 Hs.90280 5-aminoimidazole-4-carboxamide ribonucle 4.79

134859 D26488 Hs.90315 KIAA0007 protein 6.20

134891 R51083 Hs.90787 ESTs 7.40

134960 BE246400 Hs.285176 acetyl-Coenzyme A transporter 4.00

134993 BE409809 Hs.301005 purine-rich element binding protein B 4.48

135047 AL134197 Hs.93597 cyclin-dependent kinase 5, regulatory su 9.50

135080 AI761180 Hs.94211 rcdl (required for cell differentiation, 5.00

135103 NM 003428 Hs.9450 zinc finger protein 84 (HPF2) 11.00

135145 AW014729 Hs.95262 nuclear factor related to kappa B bindin 4.01

135184 U13222 Hs.96028 forkhead box D1 7.00

^'135242 AI583187 Hs.9700 cyclin E1 13.50

135286 AW023482 Hs.97849 ESTs 6.46

135289 AW372569 Hs.9788 hypothetical protein MGC10924 similar to 8.80

135355 AK001652 Hs.99423 ATP-dependent RNA helicase 10.00

135371 NM 006025 Hs.997 protease, serine, 22 8.00

135393 L11244 Hs.99886 complement component 4-binding protein, 14.60

TABLE 5B shows the accession numbers for those primekeys lacking unigenelD's for Table 5A. For each probeset we have listed the gene cluster number from which the oligonucleotides were designed. Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs. These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California). The Genbank accession numbers for sequences comprising each cluster are listed in the "Accession" column.

Pkey: Unique Eos probeset identifier number

CAT number: Gene cluster number Accession: Genbank accession numbers

Pkey CAT number Accessions

117079 1621717 1 H92325 T97125

124305 242183 1 AW963221 AA344870 AA344871 H93331

101502 18202 -6 M26958

109792 754958 1 R49625 F10674

126034 1598157 1 H60340 N91637

102768 44641 1 U82321 H66077

126345 1653833 1 N49713 N49819 W03810

127066 1703458 1 R25066 R20144 R20145 Z43845

127099 244301 1 AA347668 AW956810 Z44271 F07065 F07064 R13506

119243 1774795 1 T12603 T12604

125875 1566433 1 H14480 N98295

112054 1538292 1 R43590 F10439

126979 171411 1 AA210954 AA211007

126992 880655 1 AI809521 H12174Z42556

122318 292419 1 AA429743 AA442754

114699 135322.1 AA127386 R15644 AA127404

114793 150742.1 AA158245 AA158235

108305 111550 1 AA071391 AA069892 AA069891

108393 113411 1 AA075211 AA075245 AA075126AA074946

100867 tigr_HT4586 U14622

123731 genbank_AA609839 AA609839

109700 genbank F09609 F09609

120715 genbank_AA292700 AA292700

113702 genbank_T97307 T97307

115113 geπbank_AA256460 AA256460

101045 eπtrez J05614 J05614

108554 genbank_AA084948 AA084948

108573 genbank_AA086005 AA086005

119052 149538 1 R10889 R10888

126522 416020 1 W31912AI167491

126605 439280 1 AA676910 AA778853 AA778865 W86800

103768 46922 1 W42667 AI580740 AI690440 AI561350 AW467906 AW1

AA845593 AI623711 N68583 C00064 AA193567 AW083868 AW163216 AA191595 AA522778 AI628008 AI915518 AA843508 AI926195 AA176265 AW167963 AA992115 W93647 AW103572 AI862994 AI342059 AA911719 AA176155 AA024712 AA069988 AA205591 AI591107 AI199673AI811766AI275832AI422233AI191852AI096682AI580124AI683612AA582453AA927559AA486415T32414AI084978 H44849 H44848 H20477 T91695 W47039 AA070055 AA024795 AA328855 AA379248 AA379330 AA385580 W25920 W03688 AA448359 AA093881 AW362477 AA089997 AI350265 W93479 N99688 AA932257 AW351469 H68590 AA663402 AA069771 AW087986 AI858420 AA600214 AI970774 A1857712 AI683081 AI885584 AW131150 AI567981 AW002714 AW189973 AW075495 A 168303 AA953714 AW516881 AI357375 AI566663 AW512676 AI570580 AI023690 AA448216 AI079853 AI422707 AA779516 AW026972 AW130082 AW162307 AW438646 AA709332 AW192394 AI167350 A1217879 AI129152 AA719509 AI350480 AA663418 AI003634 AW118546 AA180261 AA442833 AI268625 AA888881 AI038759 AA846723 AI248770 AA993694 AI280335 AI885107 AW518649 AA641563 AA995835 AA582521 AI276744 AA436478 AI017360 AI620763 AI859887 N73926 AI076327 AI741615 AI160617 AW172819 AI492005 AA677429 AA996334 AI693771 AI950039 AI245629 AI288515 AI866186 T93293 AA173262 AA599779 AI680092 AW439316 AI084565 AI272672 AI583507 AW473219 AA738132 AW473283 AI367492 AA995410 AI689624 AA206353 AI033095 AI040382 AA873630 AI221074 AI934840 AI418680 AA844306 R94503 AA773520 AA843169 AA219425 AA629658 AI811719 AW411275 AI590981 W37907 AI591178 AI684051 AA983238 AA669347 AA976239 AA704570 A1628339 AI884391 AI241580 AI003539 AW176687 AA009650 N34566 AI333493 AH 86070 AA070827 AA411683 AI280884 AA872023 AA207255 AA021576 N71953 AI885888 AW076039 T15777 AI537673 AW248048 H09554 W93480 W47001 AW079114 AA063160 AA757453 R60788 AI859431 H20478 AA218882 AA757465 AA100995 AI864135 AI934209 AA070503 H47008 AA219646 W61039 W93907 AW385050 W37967 W78028 AA189007 AA479136 R93650 AA442312 T30287 AA847628 AA180262 AA009649 C03892 AW149464 AA310963 AA219693 AA069747 R29207 AA094784 AA293615 AA447848 AI984167 N90393 C05097 N56499 AW292351 AW149681 AW473258 AA629322 AI004409 AW105577AI954937AI811070AA902422AW514437AA535460AA916877AW517122AA974657AA975649AW517130AW517129 F31737 W07688 AA193645 AA378994 AA489273 F32267 W39303 AA021181 N86810 AA406524 AA062553 AA436801 H08985 H15979 N40310 AA436789 AA232172 AW360778 W25862 R60282 AA436530 AA378894 AA187461 AI940535 AA604210 AA089514 AA360421 N88243 N84281 AA209340 N56174 N88374 AA191088 AW247691 AA249013 AA093111 AA972536 AW298594 AA375893 T12139 W28186 AW243849 AI288629 AA843996 W15260 AI188286 AW248079 R15836

119599 genbaπk_W45552 W45552

112382 genbank_R59904 R59904

105264 genbaπk_AA227934 AA227934

100071 entrez_A28102 A28102

123315 714071.1 AA496369 AA496646

Table 6A shows 99 genes up-regulated nonsmokers with lung cancer relative to smokers with lung cancer. These genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression.

Pkey: Unique Eos probeset identifier number

ExAccn: Exemplar Accession number, Genbank accession number

UnigenelD: Unigene number

Unigene Title: Unigene gene title

R1 : average of Al for samples from non-smokers with adenocarcinoma divided by the 90th percentile of Al for samples from smokers with adenocarcinoma

R2: average of Al for samples from non-smokers with squamous cell carcinoma divided by the 90th percentile of Al for samples from smokers with squamous cell carcinoma

Pkey ExAccn UnigenelD Unigene Title R1 R2

100971 BE379727 Hs.83213 fatty acid binding protein 4, adipocyte 3.64

101174 L17330 Hs.280 pre-T/NK cell associated protein 15.00

101296 Y12490 Hs.85092 thyroid hormone receptor interactor 11 2.46

101304 AA001021 Hs.6685 thyroid hormone receptor interactor 8 12.00

101806 AA586894 Hs.112408 S100 calcium-binding protein A7 (psorias 2.68

101972 S82472 gbibeta -pol=DNA polymerase beta (exon a 2.11

102274 U30930 Hs.158540 UDP glycosyltransferase 8 (UDP-galactose 7.50

102394 NM 003816 i Hs.2442 a disintegrin and metalloproteinase doma 7.50

102832 U92015 gb:Human clone 143789 defective mariner 13.50

103010 X52509 Hs.161640 tyrosine amiπotransferase 9.50

103439 X98266 gb:H.sapiens mRNA for ligase like protei 2.50

103563 L02911 Hs.150402 activin A receptor, type I 9.00

103857 AI076795 Hs.45033 lacrimal proline rich protein 3.94

104239 AB002367 Hs.21355 doublecortin and CaM kinase-like 1 13.50

104590 AW373062 Hs.83623 nuclear receptor subfamily 1, group I, m 12.66

104907 AA055829 Hs.196701 ESTs, Weakly similar to ALU1.HUMAN ALU 16.50

106131 BE514788 Hs.296244 SNARE protein 2.17

106672 H47233 Hs.30643 ESTs 7.00

106872 T56887 Hs.18282 KIAA1134 protein 11.50

106960 AA156238 Hs.32501 ESTs 2.38

106971 Z43846 Hs.194478 Homo sapiens mRNA; cDNA DKFZp43401572 (f 9.50

107982 AA035375 Hs.57887 ESTs, Weakly similar to KIAA0758 protei 2.95

108562 AA100796 gb:zm26c06.s1 Stratagene pancreas (93720 16.50

108599 AB018549 Hs.69328 MD-2 protein 13.00

108663 BE219231 Hs.292653 ESTs, Weakly similar to T26845 hypotheti 2.40

109247 AA314907 Hs.85950 ESTs 7.00

109630 R44607 Hs.22672 ESTs 5.00

110193 AI004874 Hs.310764 Homo sapiens mRNA; cDNA DKFZp434M082 (fr 12.50

110234 H24458 Hs.32085 EST 16.50

110644 R94207 Hs.268989 ESTs, Highly similar to type II CALM/AF1 8.00

110886 AW274992 Hs.72249 three-PDZ containing protein similar to 17.00

111057 T79639 Hs.14629 ESTs 16.50

111950 AF071594 Hs.110457 Wolf-Hirschhom syndrome candidate 1 11.00

112291 R53972 Hs.26026 ESTs 3.00

112956 Z43784 Hs.75893 ankyrin 3, node of Ranvier (ankyrin G) 2.79

113009 T23699 Hs.7246 ESTs 4.50

113060 BE564162 Hs.250820 hypothetical protein FLJ14827 9.79

113073 N39342 Hs.103042 microtubule-associated protein 1B 32.50

113074 AK001335 Hs.31137 protein tyrosine phosphatase, receptor t 3.82

113121 T48011 Hs.8764 EST 2.21

113125 AA968672 Hs.8929 hypothetical protein FLJ 11362 19.50

113757 AA703095 Hs.18631 ESTs 2.65

113848 W52854 Hs.27099 hypothetical protein FLJ23293 similar to 6.00

113884 AI333076 Hs.28529 chromosome 12 open reading frame 2 6.00

113936 W17056 Hs.83623 nuclear receptor subfamily 1, group I, m 4.63

114875 AA235609 Hs.236443 Homo sapiens mRNA; cDNA DKFZp564N1063 ( 7.00

114987 AA251016 Hs.87808 EST 6.00

115460 AW958439 Hs.38613 ESTs 2.27

115722 W91892 Hs.59609 ESTs 9.00

116261 AA481788 Hs.190150 ESTs 9.50

116830 H61037 Hs.70404 ESTs, Weakly similar to ALU2.HUMAN ALU 8.50

116970 AB023179 Hs.9059 KIAA0962 protein 7.50

117178 H98675 Hs.269034 ESTs 2.68

117757 AF088019 Hs.46732 EST 7.50

118283 AA287747 Hs.173012 ESTs, Weakly similar to A46010 X-linked 16.50

118384 AF217525 Hs.49002 Down syndrome cell adhesion molecule 2.50

118657 AI822106 Hs.49902 ESTs 2.39

120328 AA923278 Hs.290905 ESTs, Weakly similar to protease [H.sapi 3.50

120404 AB023230 Hs.96427 KIAA1013 protem 7.00

120524 AA261852 Hs.192905 ESTs 6.00

120688 AW207555 Hs.97093 Homo sapiens cDNA: FLJ23004 fis, clone L 17.92 121558 AA412497 gb zl95g12 s1 Soares testis NHT Homo sap 295

121676 H56037 Hs 108146 ESTs 1000

121936 AI024600 Hs 98612 ESTs 1500

121938 AA428659 Hs 98610 ESTs 1400

122177 AA435789 Hs 98833 EST 893

123442 AA299652 Hs 111496 Homo sapiens cDNA FLJ 11643 fis, clone HE 1304

123551 AA608837 gb af03h12 s1 Soares testis NHT Homo sap 11 50

123756 AA609971 Hs 112795 EST 11 00

123861 AA620840 gb af89g01 s1 Soares testis.NHT Homo sap 250

124371 N24924 Hs 188601 ESTs 650

127477 BE328720 Hs 280651 ESTs 433

127591 AI190540 Hs 131092 ESTs 302

128252 AA455924 Hs 192228 ESTs 700

128426 AI265784 Hs 145197 ESTs 208

128925 R67419 Hs 21851 Homo sapiens cDNA FLJ12900 fis, clone NT 211

128945 AI990506 Hs 8077 Homo sapiens mRNA, cDNA DKFZp547E184 (fr 1000

129105 AI769160 Hs 108681 Homo sapiens brain tumor associated prat 1550

129235 AW977238 Hs 126084 KIAA1055 protein 425

129506 AB020684 Hs 11217 KIAA0877 protein 650

129595 U09550 Hs 1154 oviductal glycoprotem 1, 120kD (mucin 9 10 00

130160 AA305688 Hs 267695 UDP-Gal betaGlcNAc beta 1,3-galactosyltr 2000

130340 D82326 Hs 239106 solute carrier family 3 (cystine, dibasi 11 50

131220 AB023194 Hs 300855 KIAA0977 protein 1750

131430 AI879148 Hs 26770 fatty acid binding protein 7, brain 610

132114 NM.006152 Hs 40202 lymphoid restricted membrane protein 615

132458 AA935315 Hs 48965 Homo sapiens cDNA FLJ21693 fis, clone C 558

132647 NM.006927 Hs 54432 sialyltransferase 4B (beta-galactosidase 750

132655 D49372 Hs 54460 small inducible cytokine subfamily A (Cy 253

132682 AI077500 Hs 54900 serologically defined colon cancer antig 250

132747 AA345241 Hs 55950 ESTs, Weakly similar to KIAA1330 protein 283

132812 R50333 Hs 92186 Leman coiled-coil protein 382

133337 AF085983 Hs 293676 ESTs 500

133876 AL134906 Hs 71 phosphorylase, glycogen, liver (Hers dis 300

134119 AW157837 Hs 79226 fasciculation and elongation protein zet 206

134464 AA302983 Hs 239720 CCR4-NOT transcription complex, subunit 227

134542 M14156 Hs 85112 insulin like growth factor 1 (somatomedi 11 50

135002 AA448542 Hs 251677 G antigen 7B 8700

135305 AA203555 Hs 98288 Homo sapiens cDNA FLJ14903 fis, clone PL 6 50

TABLE 6B show the accession numbers for those primekeys lacking unigenelD's for Table 6A For each probeset we have listed the gene cluster number from which the oligonucleotides were designed Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California) The Genbank accession numbers for sequences comprising each cluster are listed in the "Accession" column

Pkey Unique Eos probeset identifier number

CAT number Gene cluster number Accession Genbank accession numbers

Pkey CAT number Accessions

108562 36375 1 AA100796 AF020589 AA074629 AA075946 AA100849 AA085347 AA126309 AA079311 AA079323 AA085274 103439 35330.1 X98266 N41124 123551 genbank_AA608837 AA608837 123861 genbank AA620840 AA620840 102832 entrez U92015 U92015 101972 entrez_S82472 S82472 121558 genbaπk_AA412497 AA412497

a e s ows genes own-regu a e in non-smo ers wit ung cancer rea ive o smo ers wi ung cancer ese genes were seec e rom pro ese s on e Eos/Affymetnx Hu03 Genechip array Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression

Pkey Unique Eos probeset identifier number

ExAccn Exemplar Accession number, Genbank accession number

UnigenelD Unigene number

Unigene Title Unigene gene title

R1 90th percentile of Al for samples from smokers with adenocarcinoma divided by the average of Al for samples from non smokers with adenocarcinoma

R2 90th percentile of Al for samples from smokers with squamous cell carcinoma divided by the average of Al for samples from non-smokers with squamous cell carcinoma

Pkey ExAccn UnigenelD Unigene Title R1 R2

100187 D17793 Hs 78183 aldo keto reductase family 1, member C3 16410

100380 D82343 Hs 18551 neuroblastoma (nerve tissue) protein 7740

100576 X00356 Hs 37058 calcitonin/calcitonin-related polypeptid 10240

100971 BE379727 Hs 83213 fatty acid binding protein 4, adipocyte 46380

101046 K01160 (NONE) 67200

101066 AW970254 Hs 889 Charot Leyden crystal protein 6600

101175 U82671 Hs 36980 melanoma antigen, family A, 2 7720

101497 W05150 Hs 37034 ho eo box A5 6280

101663 NM 003528 Hs 2178 H2B histone family, member Q 7800

101677 NM 000715 Hs 1012 complement component 4-bιndιng protein, 18620

101745 M88700 Hs 150403 dopa decarboxylase (aromatic L-ammo aci 8008

101941 S77583 gb HERVK10/HUMMTV reverse transcnptase 99 20

102125 NM.006456 Hs 288215 sialyltransferase 103 10

102242 U27185 Hs 82547 retmoic acid receptor responder (tazaro 6700

102340 U37055 Hs 278657 macrophage stimulating 1 (hepatocyte gro 71 60

102369 U39840 Hs 299867 hepatocyte nuclear factor 3, alpha 6970

102457 NM 001394 Hs 2359 dual specificity phosphatase 4 15300

102669 U71207 Hs 29279 eyes absent (Drosophila) homolog 2 6570

102796 AL079646 Hs 107019 symplekm, Huntingtin interacting protei 5880

102829 NM 006183 Hs 80962 neurotensm 26880

103207 X72790 gb Human endogenous retrovirus mRNA for 7000

103242 X76342 Hs 389 alcohol dehydrogenase 7 (class IV), mu o 212 10

103260 X78416 Hs 3155 casein, alpha 13070

103351 X89211 gb H sapiens DNA for endogenous retrovir 6460

104212 AB002298 Hs 173035 KIAA0300 protein 6680

104252 AF002246 Hs 210863 cell adhesion molecule with homology to 6380

104258 AF007216 Hs 5462 solute carrier family 4, sodium bicarbon 9440

105024 AA126311 Hs 9879 ESTs 68 20

106260 AI097144 Hs 5250 ESTs, Weakly similar to ALU1.HUMAN ALU S 7460

106440 AA449563 Hs 151393 glutamate-cysteine ligase, catalytic sub 71 10

106566 BE298210 gb 601118016F1 NIH.MGC.17 Homo sapiens c 7320

106605 AW772298 Hs 21103 Homo sapiens mRNA, cDNA DKFZp564B076 (fr 8380

106614 AA648459 Hs 335951 hypothetical protein AF301222 6230

106654 AW075485 Hs 286049 phosphoseπne aminotransferase 20240

106999 H93281 Hs 10710 hypothetical protein FLJ20417 8960

108700 AA121518 Hs 193540 ESTs, Moderately similar to 2109260A B c 6640

108810 AW295647 Hs 71331 hypothetical protein MGC5350 95 50

108857 AK001468 Hs 62180 anillin (Drosophila Scraps homolog), act 6340

109597 AA989362 Hs 293780 ESTs 8500

109691 T65568 Hs 12860 ESTs 5870

109704 AI743880 Hs 12876 ESTs 6060

110942 R63503 Hs 28419 ESTs 7640

111722 R23924 Hs 23596 EST 7460

112891 T03927 Hs 293147 ESTs, Moderately similar to A46010 X-li 6480

112992 AL157425 Hs 133315 Homo sapiens mRNA, cDNA DKFZp761 J1324 (f 7670

113073 N39342 Hs 103042 microtubule-associated protein 1B 120 20

114251 H15261 Hs 21948 ESTs 12720

115230 AA278300 Hs 124292 Homo sapiens cDNA FLJ23123 fis, clone L 17400

115291 BE545072 Hs 122579 hypothetical protein FLJ 10461 91 00

115815 AW905328 Hs 180842 nboso al protein L13 6640

115909 AW872527 Hs 59761 ESTs, Weakly similar to DAP1.HUMAN DEATH 22660

115965 AA001732 Hs 173233 hypothetical protein FLJ10970 8280

116107 AL133916 Hs 172572 hypothetical protein FLJ20093 361 60

116552 D20508 Hs 164649 hypothetical protein DKFZp434H247 6900

116571 D45652 gb HUMGS02848 Human adult lung 3' direct 6420

118466 N66741 gb yz33g08 s1 Morton Fetal Cochlea Homo 6350

120484 AA253170 Hs 96473 EST 81 60

120983 AA398209 Hs 97587 EST 81 10

121034 AL389951 Hs 271623 nucleoponn 50kD 6620

121423 AW973352 Hs 290585 ESTs 6440

122553 AA451884 Hs 190121 ESTs 6040

122946 AI718702 Hs 308026 major histocompatibility complex, class 18860

123130 AA487200 gb ab19f02 s1 Stratagene lung (937210) H 80 20

124472 N52517 Hs 102670 EST 71 00

124526 N62096 Hs 293185 ESTs, Weakly similar to JC7328 ammo aci 10490

125489 H49193 Hs 124984 ESTs, Moderately similar to ALU7.HUMAN A 7200

125731 R61771 Hs 26912 ESTs 6990

125747 NM.002884 Hs 865 RAP1A, member of RAS oncogene family 6900

126020 H79863 Hs 114243 ESTs 6240

126547 U47732 Hs 84072 transmembrane 4 superfamily member 3 6280

126966 R38438 Hs 182575 solute earner family 15 (H+/peptιde tra 60 10 127472 AA761378 Hs.192013 ESTs 70.20

127610 AA960867 Hs.150271 ESTs, Highly similar to unnamed protein 64.00

127742 AW293496 Hs.180138 ESTs 85.20

127987 AI022103 Hs.124511 ESTs 96.60

128233 AW889132 Hs.11916 ribokinase 78.90

128420 AA650274 Hs.41296 fibronectin leucine rich transmembrane p 106.90

128766 AW160432 Hs.296460 craniofacial development protein 1 66.80

129014 AW935187 Hs.170162 KIAA1357 protein 58.53

129215 AB040930 Hs.126085 KIAA1497 protein 64.20

130090 H97878 Hs.132390 zinc finger protein 36 (KOX 18) 63.80

130385 AW067800 Hs.155223 stanniocalcin 2 139.60

130732 AW890487 Hs.63984 cadherin 13, H-cadherin (heart) 64.60

131025 AB040900 Hs.6189 KIAA1467 protein 64.40

131241 BE501914 Hs.24654 Homo sapiens cDNA FLJ11640 fis, clone HE 76.20

131775 AB014548 Hs.31921 KIAA0648 protein 97.80

132240 AB018324 Hs.42676 KIAA0781 protein 71.00

132856 NM 001448 Hs.58367 glypican 4 88.40

132977 AA093322 Hs.301404 RNA binding motif protein 3 133.20

133749 L20852 Hs.10018 solute carrier family 20 (phosphate tran 59.30

133818 A1110684 Hs.7645 fibrinogen, B beta polypeptide 341.00

134264 AF149297 Hs.8087 NAG-5 prpteiπ 64.30

134265 M83772 Hs.80876 flavin containing monooxygenase 3 232.53

134346 X84002 Hs.82037 TATA box binding protein (TBP)-associate 66.00

134395 AA456539 Hs.8262 lysosomal-associated membrane protein 2 75.80

135047 AL134197 Hs.93597 cyclin-dependent kinase 5, regulatory su 108.30

135056 N75765 Hs.93765 lipoma HMGIC fusion partner 71.40

135309 AI564123 Hs.42500 ADP-ribosylation factor-like 5 70.40 TABLE 7B shows the accession numbers for those primekeys lacking unigenelD's for Table 7A. For each probeset we have listed the gene cluster number from which the oligonucleotides were designed. Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs. These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California). The Genbank accession numbers for sequences comprising each cluster are listed in the "Accession" column. Pkey: Unique Eos probeset identifier number

CAT number: Gene cluster number Accession: Genbank accession numbers

Pkey CAT number Accessions

103207 30635.-4 X72790 106566 120358 1 BE298210 AI672315 AW086489 BE298417 AA455921 AA902537 BE327124 R14963 AA085210 AW274273 AI333584 A1369742 AI039658 AI885095 AI476470 AI287650 AI885299 AI985381 AW592624 AW340136 AI266556 AA456390 AI310815 AA484951

116571 genbank_D45652 D45652 118466 genbank_N66741 N66741 101046 entrez_K01160 K01160 101941 entrez_S77583 S77583 103351 entrez_X89211 X89211 123130 genbank_AA487200 AA487200

Table 8A shows 1720 genes either up or down-regulated in lung tumors or chronically diseased lung relative to a broad collection of over 40 distinct normal body tissues. Chronically diseased lung samples represent chronic non-malignant lung diseases such as fibrosis, emphysema, and bronchitis. These genes were selected from 39494 probesets on the Eos/Affymetrix Hu02 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression.

Pkey: Unique Eos probeset identifier number

ExAccn: Exemplar Accession number, Genbank accession number

UnigenelD: Unigene number

Unigene Title: Unigene gene title

R1 : 70th percentile of Al for lung tumors divided by 90th percentile of Al for normal lung

R2: 70th percentile of Al for chronically diseased lung divided by 90(h percentile of Al for normal lung

Pkey ExAccn UnigenelD Unigene Title R1 R2

300097 AI916973 Hs.213603 ESTs 5.46 4.69

300117 AW189787 Hs.147474 ESTs 0.58 0.56

300197 A1686661 Hs.218286 ESTs 4.26 5.44

300201 AI308300 gb:ta90c06.x1 NCI CGAP Brn20 Homo sapien 0.62 0.83

300225 AI989963 Hs.197505 ESTs 1.68 1.75

300247 AW274682 Hs.161394 ESTs 1.08 2.28

300256 AI469095 Hs.298241 Transmembrane protease, serine 3 0.86 1.00

300337 AI707881 Hs.202090 ESTs 5.80 9.09

300362 Z42308 gb:HSC0FB121 normalized infant brain cDN 4.18 12.78

300374 AI859947 Hs.314158 ESTs 2.99 4.38

300387 AW270150 Hs.254516 ESTs 1.50 2.53

300440 AI421541 Hs.146164 ESTs 3.98 5.25

300441 R10367 Hs.307921 EST, Weakly similar to Z232.HUMAN ZINC F 3.18 6.80

300449 AI362967 Hs.132221 hypothetical protein FLJ12401 0.43 0.62

300469 AW135830 Hs.233955 hypothetical protein FLJ20401 0.16 0.83

300552 X85711 Hs.21838 hypothetical protein FLJ11191 4.10 9.75

300627 W27363 gb:ab37d01.r1 Stratagene HeLa cell s393 4.60 12.60

300630 AW118822 Hs.128757 ESTs 2.91 5.86

300716 AI216113 Hs.126280 hypothetical protein FLJ23393 1.00 0.92

300738 AI623332 Hs.130541 KIAA1542 protein 1.82 1.71

300777 AA235361 Hs.96840 KIAA1527 protein 4.48 8.22

300790 AI492471 Hs.188270 ESTs 1.29 1.18

300832 AI688147 Hs.220615 ESTs, Weakly similar to T03829 transcrip 5.51 8.56

300836 Z44942 Hs.22958 calcium channel alpha2-delta3 subunit 4.90 6.34

300838 AI582897 Hs.192570 hypothetical protein FLJ22028 1.70 2.81

300878 AW449802 Hs.285901 Homo sapiens cDNA FLJ20428 fis, clone KA 4.56 7.91

300897 AI890356 Hs.127804 ESTs, Weakly similar to T17233 hypotheti 2.23 1.58

300926 AA504860 gb:ab03a10.s1 Stratagene fetal retina 93 2.13 3.50

300960 AI041019 Hs.152454^' ESTs 2.74 4.46

300961 AW204069 Hs.312716 ESTs, Weakly similar to unnamed protein 1.00 1.00

300962 AA593373 Hs.293744 ESTs 1.46 1.51

300967 AA565209 Hs.269439 ESTs 0.39 1.30

300987 AW450840 Hs.148590 ESTs, Weakly similar to AF208846 1 BM-00 1.49 1.08

300988 AI927208 Hs.208952 ESTs 0.16 0.37

301050 AW136973 Hs.288516 ESTs, Weakly similar to S69890 mitogen i 3.23 1.94

301098 AA677570 Hs.185918 ESTs 6.76 14.28

301157 AA729905 Hs.231916 ESTs 3.16 8.85

301162 AI142118 Hs.129004 ESTs 1.68 7.18

301170 AA737594 Hs.247606 ESTs 4.40 6.42

301192 AI808751 Hs.121188 ESTs 6.38 11.59

301193 AA758115 Hs.128350 ESTs, Weakly similar to JC5423 2-hydroxy 4.35 7.78

301267 AW297762 Hs.255690 ESTs 1.56 1.61

301281 AA843986 Hs.190586 ESTs 2.19 1.78

301341 AI819198 Hs.208229 ESTs 0.76 0.76

301382 AA912839 Hs.163369 ESTs 1.00 1.81

301407 AW450466 Hs.126830 ESTs 1.48 1.51

301452 AA975688 Hs.159955 ESTs 0.51 1.46

301483 AW272467 Hs.254655 Untitled 2.40 5.02

301494 AI678034 Hs.131099 ESTs 2.79 3.41

301521 AI733621 Hs.133011 zinc finger protein 117 (HPF9) 0.67 0.67

301531 AI077462 Hs.134084 ESTs 2.52 3.76

301580 AI878959 Hs.73737 splicing factor, arginine/serine-rich 1 7.41 11.92

301676 Z43570 Hs.27453 ESTs, Moderately similar to G01251 Rar p 8.31 10.70

301690 F05865 Hs.108323 ubiquitiπ-conjugatiπg enzyme E2E 2 (homo 2.70 4.22

301718 F07744 Hs.7987 DKFZP434F162 protein 4.20 8.78

301799 AA384252 Hs.286132 D15F37 (pseudogene) 5.93 7.04

301804 AA581004 Hs.62180 anillin (Drosophila Scraps homolog), act 1.70 0.76

301822 X17033 Hs.271986 integrin, alpha 2 (CD49B, alpha 2 subuni 1.58 1.36

301846 R20002 Hs.6823 hypothetical protein FLJ10430 1.00 1.00

301868 T71508 Hs.13861 ESTs, Weakly similar to pH sensitive max 2.88 5.49

301882 T78054 gb:yc97g09.r1 Soares infant brain 1NIB H 2.28 3.80

301905 AI991127 Hs.117202 ESTs 1.00 1.00

301948 AA344647 Hs.116724 aldo-keto reductase family 1 , member B11 5.28 2.28

301960 AW070252 Hs.27973 KIAA0874 protein 5.38 6.48

302011 T91418 Hs.125156 transcriptional adaptor 2 (ADA2, yeast, 3.03 3.42

302016 N40834 Hs.23495 hypothetical protein FLJ 11252 1.00 1.25

302041 NM 001501 Hs.129715 gonadotropin-releasing hormone 2 0.71 0.99

302072 AJ238381 Hs.132576 paired box gene 9 1.60 1.71

302094 AI286176 Hs.6786 ESTs 0.52 1.20

302095 AW044300 Hs.137506 Homo sapiens BAC clone RP11-120J2 from 7 2.75 4.93

302148 AW269618 Hs.23244 ESTs 3.04 3.87 302155 AI088485 Hs.144759 ESTs 0.45 1.15

302201 AJ006276 Hs.159003 transient receptor potential channel 6 0.33 0.84

302202 AF097159 Hs.159140 UDP-Gal:betaGlcNAc beta 1 ,4- galactosylt 0.52 0.94

302206 AI937193 Hs.41143 phosphoinositide-specificphospholipase 2.76 3.65

302209 AF047445 Hs.159297 killer cell lectin-like receptor subfami 1.00 1.00

302235 AL049987 Hs.166361 Homo sapiens mRNA; cDNA DKFZp564F112 (fr 1.68 1.50

302290 AL117607 Hs.175563 Homo sapiens mRNA; cDNA DKFZp564N0763 (f 1.00 2.11

302328 AA354849 Hs.23240 Homo sapiens cDNA FLJ13496 fis, clone PL 9.38 13.08

302346 AL039101 Hs.194625 dyπein, cytoplasmic, light intermediate 3.27 7.24

302360 AJ010901 Hs.198267 mucin 4, tracheobronchial 2.54 1.88

302384 Y08982 Hs.202676 synaptonemal complex protein 2 1.00 0.91

302406 U86751 Hs.211956 CD3-epsilon-associated protein; antisens 2.63 2.67

302409 AF155156 Hs.218028 adaptor-related protein complex 4, epsil 5.82 9.34

302423 AB028977 Hs.225974 KIAA1054 protein 3.66 3.18

302432 AL080068 Hs.272534 Homo sapiens mRNA; cDNA DKFZp564J062 (fr 2.44 6.77

302435 AF092047 Hs.227277 sine oculis homeobox (Drosophila) homolo 0.44 0.84

302437 AB024730 Hs.227473 UDP-N-acetylglucosamiπe:a-1,3-D-mannosid 4.18 5.64

302455 AA356923 Hs.240770 nuclear cap binding protein subunit 2, 2 1.85 0.92

302472 AA317451 Hs.6335 SWI/SNF related, matrix associated, acti 2.04 2.13

302476 AF182294 Hs.241578 U6 snRNA-associated Sm-like protein LSm8 1.44 1.89

302489 T80660 Hs.230424 Homo sapiens cDNA FLJ13540 fis, clone PL 0.51 1.10

302490 AA885502 Hs.187032 ESTs 2,64 4.87

302562 AJ005585 Hs.48956 gap junction protein, beta 6 (connexin 3 5.34 2.68

302566 AA085996 Hs.248572 hypothetical protein FLJ22965 1.00 1.21

302630 AB029488 Hs.272100 SMS3 protein 0.52 1.24

302634 AB032953 Hs.173560 odd Oz/ten-m homolog 2 (Drosophila, mous 1.00 1.00

302638 AA463798 Hs.102696 MCT-1 protein 1.58 1.02

302647 X57723 Hs.198273 NADH dehydrogenase (ubiquinone) 1 beta s 2.72 6.85

302655 AJ227892 Hs.146274 ESTs 1.00 4.32

302656 AW293005 Hs.70704 Homo sapiens, clone IMAGE:2823731, mRNA, 2.97 0.93

302668 AA580691 Hs.180789 S164 protein 0.80 0.95

302679 H65022 gb:yu66g11.r1 Weiz ann Olfactory Epithel 1.68 5.04

302680 AW192334 Hs.38218 ESTs 2.70 7.98

302697 AJ001408 gb:Homo sapiens mRNA for immunoglobulin 4.25 8.13

302705 U09060 gb:Human immunoglobulin heavy chain, V-r 3.91 8.68

302711 L08442 gb:Human autonomously replicating sequen 2.20 2.73

302719 W69724 Hs.288959 hypothetical protein FLJ20920 0.54 1.02

302742 L12069 gb:Homo sapiens (clone WR4.10VH) anti-th 4.28 11.57

302755 AW384815 Hs.149208 KIAA1555 protein 1.57 2.38

302771 H98476 Hs.42522 ESTs 2.94 4.68

302789 AJ245067 gb:Homo sapiens mRNA for immunoglobulin 3.49 6.31

302795 AJ245313 Hs.272838 hypothetical protein FLJ 10494 0.80 2.74

302802 Y08250 gb:H.sapiens mRNA for variable region of 1.13 0.77

302803 AA442824 Hs.293961 ESTs, Moderately similar to putative DNA 3.14 10.68

302812 N31301 Hs.152664 hypothetical protein FLJ20051 3.04 8.24

302847 X98940 gb:H.sapiens rearranged Ig heavy chain ( 1.80 1.92

302885 AL137763 Hs.132127 hypothetical protein LOC57822 1.00 1.00

302943 AI581344 Hs.127812 ESTs, Weakly similar to T17330 hypotheti 0.53 0.67

302977 AW263124 Hs.315111 hypothetical protein FLJ 12894 2.45 2.62

303006 AF078950 Hs.24139 Homo sapiens cDNA: FLJ23137 fis, clone L 4.88 8.61

303011 AF090405 gb:Homo sapiens clone 2A1 scFV anitbody 1.41 1.86

303013 F07898 Hs.288968 RAB22A, member RAS oncogene family 1.51 1.19

303061 AF151882 Hs.27693 peptidylprolyl isomerase (cyclophilin)-l 0.72 0.76

303077 AF163305 gbiH.sapiens T-cell receptor mRNA 1.17 3.90

303090 AA443259 Hs.146286 klnesin family member 13A 4.08 6.46

303091 AF192913 Hs.130683 zinc finger protein 180 (HHZ168) 2.50 4.37

303094 AF195513 Hs.278953 Pur-gamma 5.38 8.38

303095 AF202051 Hs.134079 NM23-H8 3.26 4.08

303131 AW081061 Hs.103180 DC2 protein 2.02 1.83

303195 AA082211 Hs.233936 myosin, light polypeptide, regulatory, n 1.32 3.95

303196 AA082298 Hs.59710 ESTs 0.77 0.53

303216 AA581439 Hs.152328 ESTs 0.24 0.63

303222 AA333538 Hs.204501 hypothetical protein FLJ10534 3.56 6.22

303234 AA132255 Hs.143951 ESTs 2.28 3.17

303251 AW340037 Hs.115897 protocadherin 12 0.38 1.02

303295 AA205625 Hs.208067 ESTs 2.30 1.00

303297 T80072 Hs.13423 Homo sapiens clone 24468 mRNA sequence 1.86 4.48

303316 AF033122 Hs.14125 p53 regulated PA26 nuclear protein 0.10 0.80

303467 AA398801 Hs.323397 ESTs 4.54 9.65

303506 AA340605 Hs.105887 ESTs, Weakly similar to Homolog of rat Z 0.09 0.04

303552 AA359799 Hs.224662 ESTs, Weakly similar to unnamed protein 1.00 1.72

303598 AA382814 gb:EST96097 Testis I Homo sapiens cDNA 5 4.96 9.14

303637 AF056083 Hs.24879 phosphatidic acid phosphatase type 2C 2.06 2.02

303655 AA504702 Hs.258802 ATPase, (Na+)/K+ transporting, beta 4 po 1.00 1.24

303756 AI738488 Hs.115838 ESTs 1.08 1.43

303856 AA968589 Hs.180532 glucose phosphate isomerase 1.76 1.31

303893 N88597 Hs.113503 karyopherin (importin) beta 3 2.30 2.57

303907 AW467774 Hs.171880 polymerase (RNA) II (DNA directed) polyp 3.10 5.79

303946 AW474196 Hs.306637 Homo sapiens cDNA FLJ12363 fis, clone MA 5.06 11.86

303978 AW513315 gb:xo43c12.x1 NCI CGAP.UH Homo sapiens 5.14 7.31

303981 AW513804 Hs.278834 ESTs, Weakly similar to ALU1.HUMAN ALU S 2.83 4.06

303990 AW515465 gb:xu71a11.x1 NCI.CGAP.Kid8 Homo sapiens 1.15 2.35

303998 AW516449 gb:xt68f05.x1 NCI_CGAP_Ut2 Homo sapiens 2.20 9.35

303999 AW516611 gb:xp70b11.x1 NCI_CGAP_Ov39 Homo sapiens 4.85 6.28

304006 AW517947 gb:xt66h02.x1 NCI_CGAP_Ut2 Homo sapiens 3.21 4.07 304008 AW518198 Hs.3297 ribosomal protein S27a 6.50 11.08

304009 AW518206 Hs.181165 eukaryotic translation elongation factor 1.88 3.27

304024 T03036 gb:FB21B7 Fetal brain, Stratagene Homo s 2.15 3.55

304026 T03160 gb:FB26F2 Fetal brain, Stratagene Homo s 5.88 11.80

304028 T03266 gb:FB7C1 Fetal brain, Stratagene Homo sa 5.59 13.46

304036 T16855 Hs.244621 ribosomal protein S14 6.55 14.43

304046 T54803 gb:yb42d06.s1 Stratagene fetal spleen (9 6.18 12.19

304061 T61521 gb:yb73g01.s1 Stratagene ovary (937217) 2.64 8.23

304063 T62536 gb:yc04c12.s1 Stratagene lung (937210) H 0.53 1.61

304097 R25376 Hs.177592 ribosomal protein, large, P1 6.49 11.67

304114 R78946 gb:yi87g02.s1 Soares placenta Nb2HP Homo 2.90 4.18

304122 H28966 gb:ym31a06.s1 Soares infant brain 1NIB H 1.00 2.76

304155 H68696 gb:yr78b06.s1 Soares fetal liver spleen 0.79 1.18

304203 N56929 gb:yy82d08.s1 Soares.multiple.sclerosis. 4.28 11.34

304234 W81608 gb:zd88h06.s1 Soares_fetal_heart_NbHH19W 6.47 11.03

304267 AA064862 Hs.73742 ribosomal protein, large, P0 1.34 1.16

304270 AA069711 Hs.297753 vimentin 3.40 5.40

304287 AA079286 Hs.78466 proteasome (prosome, macropain) 26S sub 2.93 4.42

304348 AA179868 gb:zp38g12.s1 Stratagene muscle 937209 H 3.98 10.96

304415 AA290747 Hs.169476 glyceraldehyde-3-phosphate dehydrogenase 3.32 5.99

304430 AA347682 gb:EST54044 Fetal heart II Homo sapiens 1.00 1.00

304456 AA411240 gb:zv26g05.s1 Soares.NhHMPu.S1 Homo sapi 1.42 3.33

304521 AA464716 gb:zx82c11.s1 Soares ovary tumor NbHOT H 2.18 1.15

304526 AA476427 gb:zx02c05.s1 Soares_total_fetus_Nb2HF8_ 5.38 14.11

304542 AA482602 Hs.169476 glyceraldehyde-3-phosphate dehydrogenase 4.16 8.23

304546 AA486074 Hs.297681 serine (or cysteine) proteinase inhibito 0.55 1.20

304607 AA513322 gb:nh85e08.s1 NCI_CGAP_Br1.1 Homo sapien 1.95 2.10

304640 AA524440 Hs.111334 ferritin, light polypeptide 2.10 2.83

304650 AA527489 Hs.3463 ribosomal protein S23 3.33 12.62

304735 AA576453 gb:nm75h11.s1 NCI_CGAP_Co9 Homo sapiens 1.33 0.88

304760 AA580401 gb:nn13g09.s1 NCI_CGAP_Co12 Homo sapiens 3.68 8.14

304849 AA588157 Hs.13801 KIAA1685 protein 2.77 3.70

304917 AA602685 Hs.284136 PRO2047 protein 7.16 11.01

304921 AA603092 Hs.297753 vimentin 2.47 4.24

304966 AA613893 Hs.282435 ESTs 6.78 11.66

304987 AA618044 Hs.300697 immunoglobulin heavy constant gamma 3 (G 0.90 1.23

305016 AA626876 gb:zu89h06.s1 Soares.testis.NHT Homo sap 6.46 10.17

305034 AA630128 gb:ab99c04.s1 Stratagene lung (937210) H 1.00 1.00

305072 AA641012 gb:πr72a12.s1 NCI CGAP Pr24 Homo sapiens 5.68 11.59

305111 AA644187 Hs.303405 ESTs 1.48 1.37

305148 AA654070 gb:nt01g08.s1 NCI_CGAPJ_ym3 Homo sapiens 1.76 4.61

305159 AA659166 Hs.275668 EST, Weakly similar to EF1 D.HUMAN ELONG 1.00 2.15

305190 AA665955 gb:ag57d12.s1 Gessler Wilms tumor Homo s 5.31 8.14

305232 AA670052 Hs.169476 glyceraldehyde-3-phosphate dehydrogenase 0.78 1.18

305235 AA670480 gb:ag37e01.s1 Jia bone marrow stroma Horn 3.11 8.66

305245 AA676695 Hs.81328 nuclear factor of kappa light polypeptid 4.38 7.53

305312 AA700201 gb:zj44f07.s1 Soares.fetal liver.spleen. 2.13 2.66

305322 AA701597 Hs.163019 EST 1.20 1.40

305394 AA720942 Hs.300697 immunoglobulin heavy constant gamma 3 (G 1.16 0.68

305413 AA724659 gb:ai10f08.s1 Soares_parathyroid_tumor_N 5.86 9.87

306447 AA737856 gb:nx10c08.s1 NCI.CGAP.GC3 Homo sapiens 2.21 2.86

305476 AA745664 Hs.287445 hypothetical protein FLJ 11726 3.36 6.54

305483 AA748030 Hs.303512 EST 1.00 2.02

305528 AA769156 gb:nz12e05.s1 NCI.CGAP.GCB1 Homo sapiens 6.44 9.10

305612 AA782347 Hs.272572 hemoglobin, alpha 2 0.19 0.79

305614 AA782866 gb:aj09h02.s1 Soares_parathyroid_tumor_N 1.00 1.00

305616 AA782884 Hs.275865 ribosomal protein S18 7.57 10.20

305637 AA806124 gb:oe29a12.s1 NCI_CGAP_Pr25 Homo sapiens 4.78 12.42

305639 AA806138 gb:oe29c12.s1 NCI_CGAP_Pr25 Homo sapiens 0.89 0.70

305650 AA807709 gb:nw31e04.s1 NCI.CGAP.GCB0 Homo sapiens4.4 199 8.71

305690 AA813477 gb:ai67a05.s1 Soares.testis.NHT Homo sap 4.91 9.40

305726 AA828156 Hs.73742 ribosomal protein, large, P0 0.19 0.81

305728 AA828209 gb:of34a02.s1 NCI.CGAP.Kid6 Homo sapiens 5.12 9.29

305759 AA835353 gb:ak72b06.s1 Barstead spleen HPLRB2 Horn 1.66 4.11

305792 AA845256 gb:ak84a08.s1 Barstead spleen HPLRB2 Horn 2.34 4.25

305864 AA864374 Hs.73742 ribosomal protein, large, P0 0.30 1.40

305901 AA872968 gb:oh63h08.s1 NCI_CGAP_Kid5 Homo sapiens 2.10 5.21

305910 AA875981 gb:nx21h02.s1 NCI.CGAP.GC3 Homo sapiens 0.32 1.01

306015 AA897116 gb:am08b07.s1 Soares_NFL_T_GBC_S1 Homo s1.5 566 1.12

306017 AA897221 Hs.109058 ribosomal protein S6 kinase, 90kD, polyp 5.21 7.90

306020 AA897630 Hs.130027 EST 1.96 6.59

306063 AA906316 gb:ok03g03.s1 Soares.NFL_T_GBC.S1 Homos 7.38 20.69

306065 AA906725 gb:ok78g02.s1 NCI.CGAP.GC4 Homo sapiens 7.19 13.48

306104 AA910956 gb:ok85h11.s1 NCI_CGAP_Kid3 Homo sapiens 6.50 9.13

306109 AA911861 gb:og21a07.s1 NCI_CGAP_PNS1 Homo sapiens 4.21 5.25

306148 AA917409 Hs.288036 tRNA isopentenylpyrophosphate transferas 2.20 2.70

306242 AA932805 gb:oo60g04.s1 NCI_CGAP_Lu5 Homo sapiens 2.84 5.35

306288 AA936900 gb:oi53h05.s1 NCI_CGAP_HN3 Homo sapiens 1.60 1.12

306325 AA953072 Hs.210546 interleukin 21 receptor 1.65 2.26

306353 AA961382 Hs.275865 ribosomal protein S18 3.78 6.32

306375 AA968650 Hs.276018 EST, Moderately similar to JC4662 ribos 4.30 5.74

306396 AA970223 gb:op09d05.s1 NCI_CGAP_Kid6 Homo sapiens 0.95 2.45

306428 AA975110 Hs.191228 hypothetical protein FLJ20284 3.19 4.10

306442 AA976899 gb:oq35e09.s1 NCI_CGAP_GC4 Homo sapiens 4.67 7.44

306446 AA977348 gb:oq72e12.s1 NCI_CGAP_Kid6 Homo sapiens 3.92 6.27 306458 AA978186 gb:op33c06.s1 Soares_NFL_T_GBC_S1 Homos 3.35 5.77

306467 AA983508 Hs.163593 ribosomal protein L18a 3.72 5.37

306510 AA988546 gb:or84d07.s1 NCI CGAP Lu5 Homo sapiens 1.00 1.00

306555 AA994304 Hs.276083 EST, Weakly similar to RL23.HUMAN 60S R 6.61 10.91

306557 AA994530 gb:ou57e08.s1 NCI_CGAP_Br2 Homo sapiens 16.20 31.83

306572 AA995686 gb:os25o12.s1 NCI_CGAP_Kid5 Homo sapiens 2.51 6.52

306582 AA996248 gb:os18c10.s1 NCI.CGAP.Kid5 Homo sapiens 1.42 3.13

306598 AI000320 Hs.169476 glyceraldehyde-3-phosphate dehydrogenase 4.91 8.68

306605 AI000497 Hs.119500 ribosomal protein, large P2 1.96 8.60

306656 AI004024 gb:ou11b07.x1 Soares_NFL_T_GBC_S1 Homo s 0.11 0.45

306676 AI005603 Hs.284136 PRO2047 protein 9.56 17.28

306686 AI015615 gb:ov29f10.x1 Soares testis.NHT Homo sap 1.86 3.60

306702 AI022565 Hs.307670 EST 1.47 1.19

306728 AI027359 Hs.272572 hemoglobin, alpha 2 1.28 2.83

306751 AI032589 gb:ow70h12.s1 Soares fetal liver spleen 3.91 5.21

306767 AI038963 Hs.249118 ESTs 3.33 6.06

306892 AI092465 gb:qa75h12.x1 Soares_fetal_heart_NbHH19W 3.77 7.46

306897 AI093967 gb:qa33c06.s1 Soares_NhHMPu_S1 Homo sapi 2.12 2.85

306956 AI125111 gb:am66f03.s1 Barstead spleen HPLRB2 Horn 6.10 10.52

306958 AI125152 gb:am55e09.x1 Johnston frontal cortex Ho 1.72 1.56

307035 AI142774 Hs.119122 ribosomal protein L13a 2.00 4.70

307041 AI144243 gb:qb85b12.x1 Soares_fetal_heart_NbHH19W 9.12 12.56

307091 AI167439 gb:ox70h06.s1 Soares.NhHMPu.S1 Homo sapi 4.88 8.52

307181 AI189251 gb:qc99g06.x1 Soares_pregnant_uterus_NbH 3.55 6.44

307297 AI205798 Hs.111334 ferritin, light polypeptide 2.46 4.65

307317 AI208303 Hs.147333 EST 5.64 10.13

307327 AI214142 Hs.246381 CD68 antigen 3.18 5.15

307382 AI223158 Hs.147885 ESTs 2.02 3.73

307410 AI241715 Hs.77039 ribosomal protein S3A 0.72 0.48

307415 AI242118 gb:qh92b02.x1 Soares.NFL_T_GBC.S1 Homo s 2.38 3.51

307423 AI243206 Hs.179573 collagen, type I, alpha 2 2.60 5.44

307426 AI243364 gb:qh30g11.x1 Soares_NFL_T_GBC_S1 Homo s 3.18 7.67

307517 AI275055 gb:ql72d03.x1 Soares_NhHMPu_S1 Homo sapi 1.00 1.00

307551 AI281556 gb:qu52f11.x1 NCI.CGAP.Lym6 Homo sapiens 3.40 11.20

307561 AI282207 gb:qp65a12.x1 Soares.fetal.lung.NbHLI 9W 4.74 15.51

307608 AI290295 gb:qm01f02.x1 Soares_NhHMPu_S1 Homo sapi 3.50 7.19

307657 AI306428 Hs.298262 ribosomal protein S19 1.76 2.44

307691 AI318285 gb:tb17b01.x1 NCI CGAP_Ov37 Homo sapiens 1.59 1.31

307701 AI318583 Hs.276672 EST, Weakly similar to RL6_HUMAN 60S Rl 1.90 2.13

307718 AI333406 Hs.83753 small nuclear ribonucleoprotein polypept 0.45 0.99

307730 AI336092 gb:qt43b07.x1 Soares_fetal_lung_NbHL19W 1.51 0.99

307760 AI342387 gb:qt27f07.x1 Soares_pregnanLuterus_NbH 1.00 1.00

307764 AI342731 gb:qo26a07.x1 NCI_CGAP_Lu5 Homo sapiens 4.52 12.58

307783 AI347274 gb:tc05d02.x1 NCI_CGAP_Co16 Homo sapiens 1.42 1.00

307796 AI350556 gb:qt18f09.x1 NCI_CGAP_GC4 Homo sapiens 6.57 9.61

307807 AI351799 gb:qt09d02.x1 NCI_CGAP_GC4 Homo sapiens 3.38 7.68

307808 AI351826 gb:qt09g03.x1 NCLCGAP.GC4 Homo sapiens 0.33 0.86

307820 AI355761 gb:qt94a11.x1 NCI_CGAP_Co14 Homo sapiens 7.94 21.57

307830 AI358722 Hs.276737 EST, Weakly similar to R5HU22 ribosomal 2.05 3.32

307852 AI365541 gb:qz08g05.x1 NCI_CGAP_CLL1 Homo sapiens 3.18 5.21

307902 AI380462 gb:tg02h05.x1 NCI_CGAP_CLL1 Homo sapiens 3.13 4.99

307997 AI434512 Hs.181165 eukaryotic translation elongation factor 1.00 3.01

308002 AI435240 Hs.283442 ESTs 5.86 12.64

308011 AI439473 gb:ti60a08.x1 NCI_CGAP_Lym12 Homo sapien 3.79 5.83

308023 AI452732 Hs.251577 hemoglobin, alpha 1 0.38 0.88

308041 AI458824 Hs.169476 glyceraldehyde-3-phosphate dehydrogenase 4.36 6.06

308059 AI468938 Hs.276877 EST, Weakly similar to RL10.HUMAN 60S R 1.80 1.98

308085 AI474135 Hs.181165 eukaryotic translation elongation factor 3.38 4.14

308101 AI475950 Hs.181165 eukaryotic translation elongation factor 1.30 3.87

308106 AI476803 gb:tj77e12.x1 Soares NSF F8_9W OT_PA_P_S2.38 8.72

308122 AI480123 Hs.309411 EST 2.70 3.86

308154 AI500600 gb:tn93d08.x1 NCI_CGAP_Ut2 Homo sapiens 0.66 1.33

308171 AI523632 Hs.298766 ESTs, Weakly similar to schlafen4 [M.mu 2.48 4.86

308211 AI557029 Hs.278572 anaplastic lymphoma kinase (Ki-1) 2.43 2.14

308213 AI557041 gb:PT2.1_12_E04.r tumor2 Homo sapiens cD 3.34 3.79

308216 AI557135 gb:PT2.1 J 3_H06.r tumor2 Homo sapiens cD 4.61 4.78

308219 AI557246 gb:PT2.1 J 5_D07.r tumor2 Homo sapiens cD 4.87 7.94

308271 AI567844 Hs.252259 ribosomal protein S3 2.40 6.35

308319 AI583983 Hs.181165 eukaryotic translation elongation factor 2.45 3.33

308362 AI613519 Hs.105749 KIAA0553 protein 1.24 1.41

308413 AI636253 Hs.196511 ESTs 3.16 4.82

308450 AI660860 Hs.96840 KIAA1527 protein 1.79 2.68

308464 AI672425 Hs.277117 EST, Moderately similar to I38055 myosi 4.87 8.27

308588 AI718299 gb:as51g12.x1 Barstead aorta HPLRB6 Homo 3.90 5.64

308599 AI719893 gb:as47d07.x1 Barstead aorta HPLRB6 Homo 3.32 5.12

308615 AI738593 Hs.101774 hypothetical protein FLJ23045 3.11 2.36

308643 AI745040 gb:tr19a12.x1 NCI_CGAP_Ov23 Homo sapiens 3.98 3.69

308673 AI760864 gb:wi09c10.x1 NCI_CGAP_CLL1 Homo sapiens 0.82 0.99

308697 AI767143 gb:wi97a07.x1 NCI CGAP_Kid12 Homo sapien 2.76 5.59

308762 AI807405 Hs.259408 ESTs 3.17 6.30

308778 AI811109 gb:tr04o11.x1 NCI_CGAP_Ov23 Homo sapiens 1.00 1.00

308782 AI811767 Hs.2186 eukaryotic translation elongation factor 2.94 5.15

308808 AI818289 gb:wk52c01.x1 NCI_CGAP_Pr22 Homo sapiens 4.41 8.34

308823 AI824118 Hs.217493 annexin A2 1.85 1.92

308875 AI832332 gb:at48g03.x1 Barstead colon HPLRB7 Homo 2.52 3.80 308879 AI832763 Hs.75968 thymosin, beta 4, X chromosome 3.38 7.96

308886 AI833240 gb:at76d10.x1 Barstead colon HPLRB7 Homo 3.06 2.65

308898 AI858845 gb:wl32d10.x1 NCI_CGAP_Ut1 Homo sapiens 2.45 3.44

308934 AI865023 Hs.177 phosphatidylinositol glycan, class H 4.14 6.76

5 308966 AI870704 gb:w!47h01.x1 NCI_CGAP_Ut1 Homo sapiens 1.00 1.00

308979 AI873111 gb:wI52h05.x1 NCI_CGAP_Brn25 Homo sapien 7.15 11.10

309045 AI910902 gb:tq39f01.x1 NCI_CGAP_Ut1 Homo sapiens 0.61 0.59

309051 AI911975 gb:wd78d01.x1 NCI_CGAP_Lu24 Homo sapiens 1.78 4.42

, 309069 AI917366 Hs.78202 SWI/SNF related, matrix associated, act 3.27 5.88

10 309083 AI922426 Hs.119598 ribosomal protein L3 2.39 3.34

309105 A1925503 Hs.265884 ESTs 5.54 17.78

309122 AI928178 gb:wo95a11.x1 NCI_CGAP_Kid11 Homo sapien 1.00 2.92

309128 AI928816 Hs.180842 ribosomal protein L13 1.38 5.55

309164 AI937761 gb:wp84b09.x1 NCl_CGAP_Brn25 Homo sapien 2.43 3.11

15 309177 A1951118 gb:wx63g05.x1 NCI_CGAP_Br18 Homo sapiens 0.81 0.97

309288 AI991525 Hs.299426 ESTs 4.86 7.46

309299 AW003478 gb:wq66c06.x1 NCI.CGAP.GC6 Homo sapiens 4.36 9.43

309303 AW004823 gb:ws93a08.x1 NCI CGAP_Co3 Homo sapiens 2.88 7.54

309411 AW085201 Hs.244144 EST 4.30 7.14

20 309437 AW090702 Hs.278242 tubulin, alpha, ubiquitous 2.49 3.11

309459 AW117645 Hs.65114 keratin 18 2.88 4.55

309476 AW129368 gb:xe14b05.x1 NCI_CGAP_Ut4 Homo sapiens 2.08 6.60

309499 AW136325 Hs.279771 Homo sapiens clone PP1596 unknown mRNA 2.82 3.55

_ _ 309529 AW150807 Hs.181357 laminin receptor 1 (67kD, ribosomal pro 4.78 3.95

25 309532 AW151119 gb:xg33e10.x1 NCI_CGAP_Ut1 Homo sapiens 1.18 4.40

309626 AW192004 Hs.297681 serine (or cysteine) proteinase inhibit 4.46 12.06

309641 AW194230 Hs.253100 EST, Moderately similar to GHHU Ig gamm 1.47 1.39

309675 AW205681 Hs.253506 EST, Moderately similar to ATPNJHUMAN A 5.68 15.20

309693 AW237221 Hs.181357 laminin receptor 1 (67kD, ribosomal prot 1.00 1.00

30 309695 AW238011 Hs.295605 mannosidase, alpha, class 2A, member 2 5.45 9.61

309700 AW241170 Hs.179661 tubulin, beta polypeptide 1.41 1.25

309747 AW264889 gb:xq36h02.x1 NCI_CGAP_Lu28 Homo sapiens 5.00 8.35

309769 AW272346 gb:xs13c10.x1 NCI_CGAP_Kid11 Homo sapien 5.76 11.90

309782 AW275156 Hs.156110 immunoglobulin kappa constant 0.42 0.69

35 309783 AW275401 Hs.254798 EST 1.00 4.11

309799 AW276964 gb:xp58h01.x1 NCI_CGAP_Ov39 Homo sapiens 1.68 1.44

309866 AW299916 gb:xs44c01.x1 NCI_CGAP_Kid11 Homo sapien 3.02 5.04

309903 AW339071 Hs.300697 immunoglobulin heavy constant gamma 3 (G 1.05 1.18

309923 AW340684 gb:hd05g08.x1 Soares_NF T_GBC_S1 Homo s 2.30 3.67

40 309928 AW341418 gb:hd08c03.x1 Soares_NFL_T_GBC_S1 Homos 7.41 13.71

309931 AW341683 gb:hd13d01.x1 Soares_NF T GBC S1 Homo s 1.20 12.70

309933 AW341936 gb:hb73f10.x1 NCI_CGAP_Ut2 Homo sapiens 4.90 18.29

309964 AW449111 Hs.257111 hypothetical protein MGC3265 1.99 3.07

. _ 310002 AI439096 Hs.323079 Homo sapiens mRNA; cDNA DKFZp564P116 (fr 0.20 0.47

45 310096 AW136822 Hs.172824 ESTs, Weakly similar to B48013 proline-r 1.51 1.22

310098 AI685841 Hs.161354 ESTs 0.31 0.76

310109 AI203094 Hs.148633 ESTs 2.06 5.83

310112 AW197233 Hs.147253 ESTs 2.92 3.55

310115 AI611317 Hs.223796 ESTs 1.25 0.84

50 310121 AW195642 Hs.148901 ESTs 1.00 2.71

310146 A1206614 Hs.197422 ESTs 9.50 15.31

310193 AI627653 Hs.147562 ESTs 2.85 4.18

310255 AW450439 Hs.153378 ESTs 4.26 10.63

310261 AI240483 Hs.201217 ESTs 3.28 4.40

55 310264 AI915771 Hs.74170 metallothionein 1E (functional) 0.26 0.86

310275 AI242102 Hs.213636 ESTs 5.43 8.19

310282 AI243332 Hs.156055 ESTs 3.15 8.06

310290 AW013815 Hs.149103 ESTs 2.19 3.12

__Λ 310333 AI253200 Hs.145402 ESTs 1.17 1.91

60 310346 AI261340 Hs.145517 ESTs 4.81 9.95

310385 AI263392 Hs.156151 ESTs 5.96 7.79

310443 AW119018 Hs.164231 ESTs 2.90 4.63

310444 AW196632 Hs.252956 ESTs 0.85 1.01 310446 AI275715 Hs.145926 ESTs 2.18 3.85

65 310468 AI984074 Hs.196398 ESTs 3.39 5.19

310477 AI948801 Hs.171073 ESTs 1.00 1.00

310512 AW275603 Hs.200712 ESTs 3.87 8.12

310514 AI681145 Hs.160724 ESTs 3.30 7.33

__Λ 310524 AW082270 Hs.12496 ESTs, Highly similar to AC0048361 simil 0.72 1.44

70 310547 AI302654 Hs.208024 ESTs 3.26 3.46

310584 AI653007 Hs.156304 ESTs 2.39 4.08

310608 AI962234 Hs.196102 ESTs 5.60 6.49

310624 AI341594 gb:Human endogenous retrovirus H proteas 4.91 9.09

310636 AI814373 Hs.164175 ESTs 1.85 1.71

75 310648 AI347863 Hs.156672 ESTs 0.17 0.69

310694 AI654370 Hs.157752 Homo sapiens mRNA full length insert cDN 5.40 13.22

310695 AI472124 Hs.157757 ESTs 4.82 6.27 310714 AI418446 Hs.157882 ESTs 1.76 3.51

_{O Λ} 310722 AI989803 Hs.157289 ESTs 1.14 6.85

80 310756 AI916560 Hs.158707 ESTs 8.46 13.01

310764 AI376769 Hs.167172 ESTs 4.76 7.37

310848 AI459554 Hs.161286 ESTs 2.84 1.96

310851 AW291714 Hs.221703 ESTs 1.00 2.32

₀ _ 310854 AI421677 Hs.161332 ESTs 6.37 7.94

85 310858 AI871000 Hs.161330 ESTs 6.07 9.84 310864 AI924558 Hs.161399 ESTs 0.87 0.78

310875 T47764 Hs.132917 ESTs 1.00 3.63

310896 AW157731 Hs.270982 ESTs, Moderately similar to ALU7_HUMAN A 7.07 16.68

310922 AW195634 Hs.170401 ESTs 1.00 1.00

310955 AI560210 Hs.263912 ESTs 10.08 17.66

310957 AW190974 Hs.196918 ESTs 2.18 3.18

311000 AI521830 Hs.171050 ESTs 3.06 6.64

311012 AW298070 Hs.241097 ESTs 1.23 3.77

311034 AI564023 Hs.311389 ESTs, Moderately similar to PT0375 natur 2.44 2.09

311074 AW290922 Hs.199848 ESTs 6.04 14.19

311134 AI990849 Hs.196971 ESTs 3.54 6.96

311174 AW450552 Hs.205457 periaxin 0.65 0.95

311187 AI638374 Hs.224189 ESTs 2.46 2.78

311220 AI656040 Hs.196532 ESTs 1.10 2.52

311230 AI989808 Hs.197663 ESTs 1.41 1.75

311236 AI653378 Hs.197674 ESTs 2.18 2.11

311242 AW016812 Hs.200266 ESTs 0.63 5.11

311258 AI671221 Hs.199887 ESTs 1.00 1.41

311277 AW072813 Hs.270868 ESTs, Moderately similar to ALU4_HUMAN A 2.56 1.94

311294 AA826425 Hs.291829 ESTs 1.04 2.69

311308 F12664 Hs.49000 ESTs 1.96 6.70

311351 AI682303 Hs.201274 ESTs 4.77 9.38

311390 AW392997 Hs.202280 ESTs 2.80 6.06

311405 AW290961 Hs.201815 ESTs 3.80 11.66

311409 AI698839 gb:wd31f02.x1 Soares NFL T_GBC S1 Homo s 3.84 6.94

311420 AI936291 Hs.209867 ESTs 5.30 12.56

311443 AI791521 Hs.192206 ESTs 4.39 6.09

311467 AI934909 Hs.175377 ESTs 1.00 1.04

311479 AI933672 Hs.211399 ESTs 2.76 5.61

311488 R57390 Hs.301064 arfaptin 1 2.50 5.73

311495 AW300077 Hs.221358 ESTs 3.63 6.09

311511 AW444568 Hs.210303 ESTs 2.00 2.87

311534 AW130351 Hs.243549 ESTs 0.31 1.33

311537 AI805121 Hs.211828 ESTs 3.69 5.85

311543 AI681360 Hs.201259 ESTs 1.73 - 1.34

311551 AW449774 Hs.296380 POM (POM121 rat homolog) and ZP3 fusion 3.31 6.12

311557 AI819230 Hs.211238 interleukin-1 homolog 1 1.00 1.00

311558 Z44432 Hs.63128 KIAA1292 protein 2.25 3.41

311559 AW008271 Hs.265848 similar to rat myomegalin 2.68 5.90

311563 AI922143 Hs.211334 ESTs 2.39 3.32

311586 AI827834 Hs.211227 ESTs 2.47 3.85

311616 AW450675 Hs.212709 ESTs 1.00 1.00

311621 AI924307 Hs.213464 ESTs 4.16 6.74

311635 AI928456 Hs.213081 ESTs 2.17 3,76

311668 AW193674 Hs.240044 ESTs 2.60 3.12

311672 R11807 Hs.20914 hypothetical protein FLJ23056 2.79 5.18

311683 AW183738 Hs.232644 ESTs 0.19 0.96

311700 R49601 Hs.171495 relinoic acid receptor, beta 6.28 8.83

311714 AW131785 Hs.246831 ESTs, Weakly similar to CIKG_HUMAN VOLTA 5.00 8.17

311735 AW294416 Hs.144687 Homo sapiens cDNA FLJ12981 fis, clone NT 0.96 0.72

311743 T99079 Hs.191194 ESTs 1.00 1.95

311783 AI682478 Hs.13528 hypothetical protein FLJ 14054 0.16 0.77

311785 AI056769 Hs.133512 ESTs 1.34 3.97

311799 AA780791 Hs.14014 ESTs, Weakly similar to KIAA0973 protein 8.52 13.32

311819 AW265275 Hs.254325 ESTs 3.58 3.91

311823 A1089422 Hs.131297 ESTs 1.40 1.72

311877 AA349893 Hs.85339 G protein-coupled receptor 39 0.95 0.91

311886 AA522738 Hs.132554 ESTs 0.88 0.87

311896 AW206447 gb:UI-H-BI1-afg-g-02-0-Ul.s1 CI_CGAP_Su 1.66 1.13

311910 N28365 Hs.22579 Homo sapiens clone CDABP0036 mRNA sequen 1.66 2.30

311923 T60843 Hs.189679 ESTs 0.42 2.63

311933 AI597963 Hs.118726 ESTs 1.88 3.02

311959 T67262 Hs.124733 ESTs 2.02 2.33

311960 AW440133 Hs.189690 ESTs 3.87 6.62

311967 AI382726 Hs.182434 ESTs 5.80 8.14

311975 AA804374 Hs.272203 Homo sapiens cDNA FLJ20843 fis, clone AD 0.98 3.26

312005 T78450 Hs.13941 ESTs 0.12 1.39

312028 T78886 Hs.284450 ESTs 3.78 4.92

312046 AI580018 Hs.268591 ESTs 4.11 7.32

312056 T83748 Hs.268594 ESTs 2.36 3.08

312064 AA676713 Hs.191155 ESTs 3.34 5.28

312088 AW303760 Hs.13685 ESTs 1.60 1.15

312093 T91809 Hs.121296 ESTs 0.68 0.85

312094 Z78390 gb:HSZ78390 Human fetal brain S. Meier-E 3.05 4.48

312097 AI352096 Hs.112180 zinc finger protein 148 (pHZ-52) 4.52 9.70

312118 T85332 Hs.178294 ESTs 2.40 2.60

312128 AI052609 Hs.17631 Homo sapiens cDNA FLJ20118 fis, clone CO 2.39 3.53

312147 T89855 Hs.195648 ESTs 0.67 1.03

312175 AA953383 Hs.127554 ESTs 5.85 10.60

312179 A1052572 Hs.269864 ESTs 2.41 3.32

312201 AI928365 Hs.91139 solute carrier family 1 (neuronalfepithe 0.24 0.89

312207 H90213 Hs.191330 ESTs 2.20 4.55

312220 N74613 gb:za55a07.s1 Soares fetal liver spleen 4.28 11.13

312252 AI128388 Hs.143655 ESTs 1.64 1.57

312304 AA491949 Hs.269392 ESTs 0.12 2.47 312318 AW235092 Hs.143981 ESTs 3.46 5.69

312319 AA216698 Hs.180780 TERA protein 5.78 4.46

312321 R66210 Hs.186937 ESTs 0.44 1.74

312331 AA825512 Hs.289101 glucose regulated protein, 58kD 3.73 5.96

312339 AA524394 Hs.165544 ESTs 3.07 0.95

312363 AI675558 Hs.181867 ESTs 10.08 16.73

312375 AI375096 Hs.172405 cell division cycle 27 2.78 3.71

312376 R52089 Hs.172717 ESTs 1.00 1.00

312389 AI863140 gb:tz43h12.x1 NCI.CGAP Brπ52 Homo sapien 2.37 3.98

312437 AA995028 gb:RC4-BT0629-120200-011-b10 BT0629 Homo 4.06 5.41

312440 AI051133 Hs.133315 Homo sapiens mRNA; cDNA DKFZp761 J1324 (f 1.00 1.00

312451 R59989 Hs.176539 ESTs 4.96 10.04

312458 AI167637 Hs.146924 ESTs 1.11 1.00

312507 AI168177 Hs.143653 ESTs 5.89 8.24

312520 AI742591 Hs.205392 ESTs 3.30 8.92

312548 AI566228 Hs.159426 hypothetical protein PR02121 1.38 1.65

312564 H21520 Hs.35088 ESTs 0.40 0.77

312583 AI193122 Hs.124141 ESTs 0.13 0.94

312599 AI865073 Hs.125720 ESTs 3.75 5.29

312602 AA046451 Hs.165200 ESTs 6.78 12.93

312645 H52121 Hs.193007 ESTs 0.38 1.13

312666 AI240582 Hs.214678 ESTs 0.98 2.03

312689 AW450461 Hs.203965 ESTs 0.21 0.61

312817 H75459 Hs.233425 ESTs 1.51 0.85

312846 AW152104 Hs.200879 ESTs 8.93 13.78

312873 AI690071 Hs.283552 ESTs, Weakly similar to unnamed protein 4.20 6.23

312893 AI016204 Hs.172922 ESTs 2.67 3.15

312902 AW292797 Hs.130316 ESTs, Weakly similar to T2D3 HUMAN TRANS 1.19 0.71

312925 N90868 Hs.271695 ESTs 2.50 4.25

312936 AI681581 Hs.121525 ESTs 1.00 1.17

312975 AI640506 Hs.293119 ESTs, Weakly similar to ALU7_HUMAN ALU S 2.30 4.80

312978 N24887 Hs.292500 ESTs 0.80 1.05

312980 AA497043 Hs.115685 ESTs 3.12 3.60

312984 N25871 Hs.177337 ESTs 2.03 2.13

313000 AI147412 Hs.146657 ESTs 5.52 8.42

313029 AA731520 Hs.170504 ESTs 0.96 1.39

313039 AI419290 Hs.149990 ESTs, Weakly similar to unnamed protein 6.48 13.20

313049 AW293055 Hs.119357 ESTs 6.44 10.73

313056 AI651930 Hs.135684 ESTs 1.51 2.04

313058 D81015 Hs.125382 ESTs 0.25 1.50

313070 AI422023 Hs.161338 ESTs 8.56 11.60

313097 AI676164 Hs.204339 ESTs 3.72 4.56

313130 AW449171 Hs.168677 ESTs 3.28 5.06

313136 N59284 Hs.288010 ESTs 0.49 1.36

313153 AI240838 Hs.132750 ESTs 5.36 5.52

313210 N74077 Hs.197043 ESTs 0.30 0.66

313236 AW238169 Hs.83513 ESTs, Weakly similar to ALU1 HUMAN ALU S 5.16 8.76

313239 W19632 Hs.124170 ESTs 1.00 3.87

313265 N93466 Hs.121764 ESTs, Weakly similar to testicular iekti 0.74 2.06

313267 AI770008 Hs.129583 ESTs 0.23 1.30

313275 AI027604 Hs.159650 ESTs 6.68 9.57

313290 AI753247 Hs.29643 Homo sapiens cDNA FLJ13103 fis, clone NT 1.34 1.07

313292 AI362991 Hs.202121 ESTs, Weakly similar to env protein [H.s 2.00 4.32

313325 AI420611 Hs.127832 ESTs 1.20 2.27

313357 AW074848 Hs.201501 ESTs 4.02 5.33

313393 AI674685 Hs.200141 ESTs 1.36 2.84

313399 AW376889 Hs.194097 ESTs 2.58 5.26

313414 AI241540 Hs.132933 ESTs 6.57 15.07

313417 AA741151 Hs.137323 ESTs 0.63 3.01

313457 AA576052 Hs.193223 Homo sapiens cDNA FLJ 11646 fis, clone HE 2.78 4.70

313499 AI261390 Hs.146085 KIAA1345 protein 0.91 2.37

313516 AA029058 Hs.135145 ESTs 3.41 7.08

313556 AA628517 Hs.118502 ESTs 0.23 0.70

313569 AI273419 Hs.135146 hypothetical protein FLJ13984 1.88 1.00

313570 AA041455 Hs.209312 ESTs 0.73 2.27

313638 AI753075 Hs.104627 Homo sapiens cDNA FLJ10158 fis, clone HE 1.00 1.72

313662 AA740151 Hs.130425 ' ESTs 0.20 1.42

313671 W49823 Hs.104613 RP42 homolog 1.00 1.00

313672 AW468891 Hs.122948 ESTs 3.46 5.80

313690 AI493591 Hs.78146 platelet/endothelial cell adhesion molec 0.51 0.97

313711 AA398070 Hs.133471 ESTs 0.18 1.01

313723 AA070412 gb:zm68c10.s1 Stratagene neuroepithelium 1.08 1.03

313726 AI744687 Hs.257806 ESTs 2.13 2.99

313774 AW136836 Hs.144583 ESTs 1.38 1.19

313784 AA910514 Hs.134905 ESTs 3.88 5.78

313790 AW078569 Hs.177043 ESTs 0.22 2.06

313832 AW271022 Hs.133294 ESTs 1.15 0.91

313834 AW418779 Hs.114889 ESTs 0.68 3.14

313835 AI538438 Hs.159087 ESTs 5.74 8.88

313852 H18633 Hs.123641 protein tyrosine phosphatase, receptor t 0.16 1.14

313854 AW470806 Hs.275002 ESTs 2.09 4.06

313865 AA731470 Hs.163839 ESTs 3.41 4.09

313871 AW471088 Hs.145950 ESTs 5.28 6.83

313883 AI949384 gb:nu76d01.s1 NCI_CGAP_Alv1 Homo sapiens 2.90 10.91

313915 AI969390 Hs.163443 Homo sapiens cDN A FLJ 11576 fis, clone HE 1.00 1.00 313926 AW473830 Hs.171442 ESTs 3.40 4.11

313948 AW452823 Hs.135268 ESTs 5.77 9.15

313978 AI870175 Hs.13957 ESTs 0.46 0.75

313983 AI829133 Hs.226780 ESTs 4.10 6.40

314035 AA164199 Hs.270152 ESTs 5.88 7.90

314037 AW300048 Hs.275272 ESTs 1.00 3.79

314040 AA166970 Hs.118748 ESTs 7.60 11.33

314067 AW293538 Hs.51743 KIAA1340 protein 1.86 1.21

314103 AI028477 Hs.132775 ESTs 2.90 5.29

314107 AA806113 Hs.189025 ESTs 2.00 1.66

314113 AA218986 Hs.118854 ESTs 0.91 4.17

314124 AW118745 Hs.9460 Homo sapiens mRNA; cDNA DKFZp547C244 (fr 2.53 3.32

314126 AA226431 gb:πc18b12.s1 NCI.CGAP Prl Homo sapiens 3.13 5.08

314128 AA935633 Hs.194628 ESTs 2.90 6.35

314151 AA236163 Hs.202430 ESTs 4.15 6.45

314184 AW081795 Hs.233465 ESTs 3.44 4.65

314192 AW290975 Hs.118923 ESTs 1.00 1.23

314244 AL036450 Hs.103238 ESTs 2.88 3.67

314253 AA278679 Hs.189510 ESTs 4.98 7.16

314262 AW086215 Hs.246096 ESTs 0.38 1.94

314320 AA811598 Hs.275809 ESTs 3.34 5.66

314332 AL037551 Hs.95612 ESTs 2.85 2.09

314335 AA287443 Hs.142570 Homo sapiens clone 24629 mRNA sequence 4.35 4.78

314340 AW304350 Hs.130879 ESTs, Moderately similar to putative p15 0.77 0.86

314351 AA292275 Hs.193746 ESTs 3.07 3.77

314376 AI628633 Hs.324679 ESTs 4,10 6.11

314443 AA827125 Hs.192043 ESTs 6.20 13.67

314458 AI217440 Hs.143873 ESTs 0.58 2.49

314466 AA767818 Hs.122707 ESTs 2.53 2.62

314478 AI521173 Hs.125507 DEAD-box protein 3.94 5.65

314482 AL043807 Hs.134182 ESTs 1.30 1.44

314506 AA833655 Hs.206868 Homo sapiens cDNA FLJ14056 fis, clone HE 3.28 3.47

314519 R42554 Hs.210662 T-box, brain, 1 3.12 6.16

314529 AL046412 Hs.202151 ESTs 3.43 6.87

314546 AW007211 Hs.16131 hypothetical protein FLJ 12876 1.38 1.00

314562 AI564127 Hs.143493 ESTs 2.29 5.27

314579 AW197442 Hs.116998 ESTs 3.87 5.75

314580 AW451832 Hs.255938 ESTs, Moderately similar to KIAA1200 pro 0.10 0.71

314585 AA918474 Hs.216363 ESTs 1.08 1.40

314589 AW384790 Hs.153408 Homo sapiens cDNA FLJ10570 fis, clone NT 1.00 1.00

314592 AA435761 Hs.192148 ESTs 0.90 2.60

314603 AA418024 Hs.270670 ESTs 4.56 6.29

314604 AA946582 Hs.8700 deleted in liver cancer 1 3.42 3.92

314606 AA418241 Hs.188767 ESTs 2.97 4.55

314648 AA878419 gb:EST391378 MAGE resequences, MAGP Homol .42 1.36

314699 AI038719 Hs.132801 ESTs 3.66 4.97

314701 AI754634 Hs.131987 ESTs 0.03 0.90

314710 AI669131 Hs.290989 EST 3.40 7.52

314750 AI095005 Hs.135174 ESTs 2.80 6.54

314767 AW135412 Hs.164002 ESTs 3.20 4.26

314801 AA481027 Hs.109045 hypothetical protein FLJ 10498 1.00 1.00

314817 AI694139 Hs.192855 ESTs 0.91 0.99

314835 AI281370 Hs.76064 ribosomal protein L27a 5.75 7.44

314852 AI903735 gb:MR-BT035-200199-031 BT035 Homo sapien 1.68 4.34

314853 AA729232 Hs.153279 ESTs 0.60 1.85

314940 AW452768 Hs.162045 ESTs 10.10 16.20

314941 AA515902 Hs.130650 ESTs 0.31 1.02

314943 AI476797 Hs.184572 cell division cycle 2, G1 to S and G2 to 2.18 0.37

314955 AA521382 Hs.192534 ESTs 2.59 3.90

314973 AW273128 Hs.300268 ESTs 1.05 1.25

315004 AA527941 Hs.325351 EST 5.64 13.63

315006 AI538613 Hs.298241 Transmembrane protease, serine 3 0.52 1.78

315033 AI493046 Hs.146133 ESTs 2.46 1.00

315035 AI569476 Hs.177135 ESTs 0.34 1.33

315056 AI202703 Hs.152414 ESTs 2.10 2.64

315069 AI821517 Hs.105866 ESTs 1.00 1.30

315071 AA552690 Hs.152423 Homo sapiens cDNA: FLJ21274 fis, clone C 1.78 1.00

315073 AW452948 Hs.257631 ESTs 1.17 1.52

315078 AA568548 Hs.190616 ESTs 3.00 3.79

315080 AA744550 Hs.136345 ESTs 1.00 1.00

315120 AA564991 Hs.269477 ESTs 0.64 1.44

315175 AI025842 Hs.152530 ESTs 0.61 1.91

315193 AI241331 Hs.131765 ESTs 1.06 0.97

315196 AA972756 Hs.44898 Homo sapiens clone TCCCTA00151 mRNA sequ 0.48 1.96

315200 AI808235 Hs.307686 EST 3.76 9.40

315254 AI474433 Hs.179556 ESTs 5.37 9.36

315353 AW452608 Hs.279610 hypothetical protein FLJ10493 1.00 1.30

315397 AA218940 Hs.137516 fidgetin-like 1 3.38 2.24

315403 AW362980 Hs.163924 ESTs 2.04 5.23

315431 AA622104 Hs.184838 ESTs 2.36 8.04

315454 AI239473 gb:qh36f02.x1 Soares_NFL_T_GBC_S1 Homos 3.46 7.64

315455 AW393391 Hs.156919 ESTs 3.78 5.76

315473 AI681671 Hs.312671 ESTs, Moderately similar to OVCA1 0.89 2.15

315483 AW512763 Hs 222024 transcription factor BMAL2 2.32 1.96

315526 A1193048 Hs.128685 ESTs 1.67 1.78 315530 AI200852 Hs.127780 ESTs 1.05 1.01

315541 AI168233 Hs.123159 sperm associated antigen 4 0.85 0.56

315552 AW445034 Hs.256578 ESTs 1.00 2.22

315562 AA737415 Hs.152826 ESTs 2.66 2.48

315577 AW513545 Hs.17283 hypothetical protein FLJ10890 2.20 2.25

315587 AI268399 Hs.140489 ESTs 1.00 1.04

315589 AW072387 Hs.158258 Homo sapiens mRNA; cDNA DKFZp434B1272 (f 0.14 1.05

315623 AA364078 Hs.258189 ESTs 7.44 12.56

315634 AA837085 Hs.220585 ESTs 0.50 1.40

315668 AA912347 Hs.136585 ESTs 0.43 1.22

315677 AI932662 Hs.164073 ESTs 0.60 1.39

315706 AW440742 Hs.155556 hypothetical protein FLJ20202 2.18 3.77

315707 AI418055 Hs.161160 ESTs 2.88 2.63

315730 H25899 Hs.201591 ESTs 0.11 0.60

315745 AI821759 Hs.191856 ESTs 3.50 7.25

315791 AA678177 gb:zi15a05.s1 Soares fetal.liver spleen 1.78 2.63

315801 AA827752 Hs.266134 ESTs 4.31 6.23

315820 AI652022 Hs.258785 ESTs 2.35 3.01

315878 AA683336 Hs.189046 ESTs 2.12 2.64

315905 AI821911 Hs.209452 ESTs 1.03 1.97

315923 AI052789 Hs.133263 ESTs 2.63 5.06

315954 AW276810 Hs.254859 ESTs, Moderately similar to ALU5 HUMAN A 1.21 0.85

315978 AA830893 Hs.119769 ESTs 3.09 3.41

316001 AI248584 Hs.190745 Homo sapiens cDNA: FLJ21326 fis, clone C 2.20 6.82

316011 AW516953 Hs.201372 ESTs 0.35 1.63

316012 AA764950 Hs.119898 ESTs 6.56 8.13

316040 AI983409 Hs.189226 ESTs 5.69 10.69

316048 AI720759 Hs.224971 ESTs 2.84 10.45

316076 AW297895 Hs.116424 ESTs 0.30 1.05

316124 AI308862 Hs.167028 ESTs 1.00 1.43

316151 AI806016 Hs.156520 ESTs 5.80 9.03

316187 AW518299 Hs.192253 ESTs 1.20 3.96

316204 AA731509 Hs.120257 ESTs 4.92 6.94

316232 AW297853 Hs.251203 ESTs 1.48 1.60

316275 AI671041 Hs.292611 ESTs, Moderately similar to ALU1 HUMAN A 5.86 12.14

316291 AW375974 Hs.156704 ESTs 2.73 2.69

316303 AA740994 Hs.209609 ESTs 1.53 1.26

316344 AA744518 Hs.120610 ESTs 3.66 8.34

316346 AI028478 Hs.157447 ESTs 3.51 6.69

316365 AI627845 Hs.210776 ESTs 2.50 4.33

316380 AI393378 Hs.164496 ESTs 1.16 2.16

316470 AA809902 Hs.243813 ESTs 5.40 10.34

316509 AA767310 Hs.291766 ESTs 2.46 2.89

316514 AA768037 Hs.291671 ESTs 4.70 6.04

316519 AI929097 gb:od10c11.s1 NCI CGAP_GCB1 Homo sapiens 4.41 9.70

316609 AW292520 Hs.122082 ESTs 1.00 2.89

316633 AI125586 Hs.127955 ESTs 2.61 3.72

316700 AW172316 Hs.252961 ESTs, Weakly similar to ALU1 HUMAN ALU S 3.46 4.64

316711 AI743721 Hs.285316 ESTs, Moderately similar to ALU7_HUMAN A 4.45 6.95

316713 AI090671 Hs.134807 hypothetical protein FLJ12057 0.30 2.40

316715 AI440266 Hs.170673 ESTs, Weakly similar to AF126780 1 retin 0.20 1.45

316787 AW369770 Hs.130351 ESTs 4.05 5.53

316809 AA825839 Hs.202238 ESTs 2.25 3.82

316811 AA922060 Hs.132471 ESTs 1.00 1.32

316812 AW135045 Hs.232001 ESTs 3.28 4.70

316818 AA827176 Hs.124316 ESTs 0.67 1.81

316824 AA837416 Hs.124299 ESTs 3.53 6.00

316827 AI380429 Hs.172445 ESTs 0.72 1.56

316891 AW298119 Hs.202536 ESTs 1.64 2.97

316951 AA134365 Hs.57548 ESTs 1.45 1.08

316970 AA860172 Hs.132406 ESTs 1.00 1.53

316971 AA860212 Hs.170991 ESTs 1.08 1.96

316990 AA861611 Hs.130643 ESTs 5.44 10.04

317001 AI627917 Hs.233694 hypothetical protein FLJ11350 3.56 4.37

317008 AW051597 Hs.143707 ESTs 0.69 1.37

317051 AA873253 Hs.126233 ESTs 6.18 12.72

317128 AA971374 Hs.125674 ESTs 1.87 2.66

317129 H12523 Hs.78521 Homo sapiens cDNA: FLJ21193 fis, clone C 4.12 6.64

317137 AW341567 Hs.125710 ESTs 2.82 5.12

317196 AI348258 Hs.153412 ESTs 1.98 2.51

3(7212 AI866468 Hs.148294 ESTs 1.86 2.83

317223 AW297920 Hs.130054 ESTs 0.83 1.57

317224 D56760 Hs.93029 sparc/osteonectin, cwcv and kazal-like d 2.74 0.86

317266 AA906289 Hs.203614 ESTs 1.00 1.00

317282 AI807444 Hs.176101 ESTs 2.60 4.21

317285 AW370882 Hs.222080 ESTs 1.96 3.49

317302 AA908709 Hs.135564 ESTs 7.16 8.32

317304 AW449899 Hs.130184 ESTs 1.38 2.28

317320 AA927151 Hs.130452 ESTs 3.58 8.13

317413 AW341701 Hs.126622 ESTs 2.08 4.92

317417 AA918420 Hs.145378 ESTs 3.06 4.79

317452 AA972965 Hs.135568 ESTs 4.22 9.21

317519 AI859695 Hs.126860 ESTs 1.88 4.15

317521 AI824338 Hs.126891 ESTs 3.12 4.55

317529 AI916517 Hs.126865 ESTs 2.73 3.34 317570 AI733361 Hs 127122 ESTs 1 00 243

317571 AA938663 Hs 199828 ESTs 520 11 95

317598 AW206035 Hs 192123 ESTs 033 1 56

317627 AI346110 Hs 132553 ESTs 1 50 1 39

317650 AI733310 Hs 127346 ESTs 048 1 46

317659 AA961216 Hs 127785 ESTs 418 7 14

317674 AW294909 Hs 132208 ESTs 292 320

317686 AA969051 Hs 187319 ESTs 1 00 1 01

317692 AI307659 Hs 174794 ESTs 533 959

317701 AI674774 Hs 128014 ESTs 1 00 1 00

317711 AI733015 Hs 272189 ESTs 513 781

317722 AI733373 Hs 128119 ESTs 250 603

317756 AA973667 Hs 128320 ESTs 1 59 1 30

317777 AI143525 Hs 47313 KIAA0258 gene product 1 00 248

317799 AI498273 Hs 128808 ESTs 1 78 211

317803 AA983251 Hs 128899 ESTs 080 1 06

317821 AI368158 Hs 70983 PTPL1 -associated RhoGAP 1 017 068

317848 AI820575 Hs 129086 Homo sapiens cDNA FLJ12007 fis, clone HE 530 816

317850 N29974 Hs 152982 hypothetical protein FLJ13117 1 30 228

317861 AW341064 Hs 129119 ESTs 218 593

317865 AI298794 Hs 129130 ESTs 448 8 20

317869 AW295184 Hs 129142 deoxynbonuclease II beta 044 099

317881 AI827248 Hs 224398 Homo sapiens cDNA FLJ11469 fis, clone HE 406 223

317890 AI915599 Hs 129225 ESTs 468 748

317899 A1952430 Hs 150614 ESTs, Weakly similar to ALU4.HUMAN ALU S 314 337

317986 AI005163 Hs 201378 ESTs, Weakly similar to T12545 hypotheti 028 1 66

318001 AW235697 Hs 130980 ESTs 5 12 997

318016 AI016694 Hs 256921 ESTs 1 86 450

318023 AW243058 Hs 131155 ESTs 292 522

318054 AW449270 Hs 232140 ESTs 392 637

318068 AI024540 Hs 131574 ESTs 1 21 1 27

318117 AI208304 Hs 250114 ESTs 086 1 17

318187 AI792585 Hs 133272 ESTs, Weakly similar to ALUC HUMAN "« 590 698

318223 AI077540 Hs 134090 ESTs 1 05 090

318240 AI085377 Hs 143610 ESTs 310 240

318255 AI082692 Hs 134662 ESTs 002 1 05

318266 AI554341 Hs 271443 ESTs 612 1055

318330 AI093840 Hs 143758 ESTs 498 790

318369 AI493501 Hs 170974 ESTs 246 562

318428 AI949409 Hs 194591 ESTs 077 045

318458 AI149783 Hs 158438 ESTs 3 54 492

318467 AI151395 Hs 144834 ESTs 456 562

318473 AI939339 Hs 146883 ESTs 208 405

318476 AI693927 Hs 265165 ESTs 422 807

318487 AI167877 Hs 143716 ESTs 1 47 1 05

318488 AI217431 Hs 144709 ESTs 1 40 414

318491 T26477 Hs 22883 ESTs, Weakly similar to ALU8 HUMAN ALU S 1 84 1 90

318499 T25451 gb PTHI188 HTCDL1 Homo sapiens cDNA 573 258 520

318537 AA377908 Hs 13254 ESTs 326 418

318538 N28625 Hs 74034 Homo sapiens clone 24651 mRNA sequence 035 1 07

318547 R20578 Hs 90431 ESTs 3 22 460

318552 R18364 Hs 90363 ESTs 487 906

318575 R55102 Hs 107761 ESTs, Weakly similar to unnamed protein 1 91 1 98

318580 T34571 Hs 49007 poly(A) polymerase alpha 274 622

318587 AA779704 Hs 168830 Homo sapiens cDNA FLJ12136 fis, clone MA 085 246

318596 AI470235 Hs 172698 EST 488 493

318622 T48325 Hs 237658 apolipoprotem A-ll 480 1251

318629 N25163 Hs 8861 ESTs 039 1 04

318637 AA243539 Hs 9196 hypothetical protein 1 72 3 57

318648 T77141 Hs 184411 albumin 6 27 991

318650 AA393302 Hs 1 6626 hypothetical protein EDAG-1 396 884

318671 AA188823 Hs 299254 Homo sapiens cDNA FLJ23597 fis, clone L 1 53 081

318679 T58115 Hs 10336 ESTs 1 00 2 19

318711 AI936475 Hs 101282 Homo sapiens cDNA FLJ21238 fis, clone C 305 3 18

318725 AI962487 Hs 242990 ESTs 1 08 246

318728 Z30201 Hs 291289 ESTs, Weakly similar to ALU1_HUMAN ALU S 077 1 33

318740 NM 002543 Hs 77729 oxidised low density lipoprotem (lectm 025 1 49

318776 R24963 Hs 23766 ESTs 1 00 301

318784 H00148 Hs 5181 proliferation-associated 2G4, 38kD 270 386

318816 F07873 Hs 21273 ESTs 390 713

318865 H10818 gb ym04f10 r1 Soares infant brain 1NIB H 225 356

318879 R56332 Hs 18268 adenylate kinase 5 1 78 500

318881 Z43224 Hs 124952 ESTs 479 14 13

318894 F08138 Hs 7387 DKFZP564B116 protein 531 700

318901 AW368520 Hs 301528 L-kynurenme/alpha amiπoadipate aminotra 1 03 091

318925 Z43577 Hs 21470 ESTs 223 380

318936 AI219221 Hs 308298 ESTs 1 86 716

318982 Z44140 Hs 269622 ESTs 584 979

318986 Z44186 Hs 169161 ESTs, Highly similar to MAON_HUMAN NADP- 1 00 1 00

319041 Z44720 Hs 98365 ESTs, Weakly similar to weak similarity 338 6 11

319103 H05896 Hs 4993 KIAA1313 protein 1 00 1 07

319170 R13678 Hs 285306 putative selenocysteme lyase 379 503

319196 F07953 Hs 16085 putative G-protein coupled receptor 1 00 298

319199 F07361 Hs 13306 ESTs 353 566

319242 F11472 Hs 12839 ESTs 587 726 319263 T65331 Hs.81360 Homo sapiens cDNA: FLJ21927 fis, clone H 1.81 1.57

319267 F11802 Hs.6818 ESTs 1.10 4.72

319270 R13474 Hs.290263 ESTs 4.80 10.40

319279 T65094 Hs.12677 CGI-147 protein 1.50 2.11

319282 AA461358 Hs.12876 ESTs 1.00 1.00

319289 W07304 Hs.79059 transforming growth factor, beta recepto 0.18 0.68

319291 W86578 Hs.285243 hypothetical protein FLJ22029 0.26 0.62

319293 F12119 Hs.12583 ESTs 3.13 4.50

319312 Z45481 gb:HSC2QE041 normalized infant brain cDN 1.10 1.00

319370 H54254 Hs.325823 ESTs, Moderately similar to ALU5 HUMAN A 0.16 0.73

319391 R06304 Hs.13911 ESTs 1.26 2.43

319396 H67130 Hs.301743 ESTs 0.70 0.76

319398 AA359754 Hs.191196 ESTs 2.45 3.59

319407 R05329 gb:ye91 b04.r1 Soares fetal liver spleen 2.00 3.54

319425 T82930 gb:yd39f07.r1 Soares fetal liver spleen 4.28 8.81

319433 R06050 Hs.191198 ESTs 6.15 14.13

319437 AA282420 Hs.111991 ESTs, Weakly similar to Y48A5A.1 [C.eleg 3.26 5.68

319466 AI809937 Hs.116417 ESTs 1.76 5.65

319471 R06546 Hs.19717 ESTs 4.29 4.84

319480 R06933 Hs.184221 ESTs 1.00 1.00

319484 T91772 gb:yd52a10.s1 Soares fetal liver spleen 2.81 4.88

319486 AI382429 Hs.250799 ESTs 2.08 2.82

319508 T99898 Hs.270104 ESTs, Moderately similar to ALU8 HUMAN A 2.80 4.39

319523 T69499 Hs.191184 ESTs 1.55 3.25

319545 R83716 Hs.14355 Homo sapiens cDNA FLJ13207 fis, clone NT 1.65 1.19

319546 R09692 gb:yf23b12x1 Soares fetal liver spleen 5.11 8.54

319552 AA096106 Hs.20403 ESTs 1.89 3.36

319582 T82998 Hs.250154 hypothetical protein FLJ 12973 3.48 4.82

319586 D78808 Hs.283683 chromosome 8 open reading frame 4 0.26 0.82

319604 R11679 Hs.297753 vimentin 1.68 3.41

319609 AW247514 Hs.12293 hypothetical protein FLJ21103 3.06 4.24

319611 H14957 gb:ym19c10.r1 Soares infant brain 1NIB H 2.76 4.24

319653 AA770183 Hs.173515 uncharacterized hypothalamus protein HTO 2.51 3.55

319657 R19897 Hs.106604 ESTs 5.32 7.68

319658 R13432 Hs.167481 syntrophin, gamma 1 3.35 5.00

319661 H08035 Hs.21398 ESTs, Moderately similar to A Chain A, H 5.18 12.55

319662 H06382 Hs.21400 ESTs 1.58 1.56

319708 R15372 Hs.22664 ESTs 1.00 1.22

319742 T77668 Hs.21162 ESTs 2.48 3.13

319748 R18178 Hs.295866 Homo sapiens mRNA; cDNA DKFZp434N1923 (f 3.02 4.85

319772 R76633 Hs.22646 ESTs 4.36 11.61

319788 AA321932 Hs.117414 KIAA1320 protein 2.56 3.68

319805 R92857 Hs.271350 likely orthoiog of mouse polydom 4.63 6.56

319812 N74880 Hs.264330 N-acylsphingosine amidohydrolase (acid c 0.63 1.32

319834 AA071267 gb:zm61g01.r1 Stratagene fibroblast (937 0.30 0.94

319878 T78517 Hs.13941 ESTs 3.99 6.44

319882 AA258981 Hs.291392 ESTs 5.09 7.36

319912 T77559 Hs.94109 Homo sapiens cDNA FLJ 13634 fis, clone PL 3.24 3.21

319935 H79460 Hs.271722 ESTs, Weakly similar to ALU1 HUMAN ALU S 4.40 9.42

319944 T79248 Hs.133510 ESTs 3.31 5.39

319947 AA160967 Hs.14479 Homo sapiens cDNA FLJ14199 fis, clone NT 2.90 4.95

319962 H06350 Hs.135056 Human DNA sequence from clone RP5-850E9 1.81 1.57

320007 AA336314 gb:EST40943 Endometrial tumor Homo sapie 3.42 6.29

320018 T83263 gb:yd40h09.r1 Soares fetal liver spleen 2.77 5.14

320030 H63789 Hs.296288 ESTs, Weakly similar to KIAA0638 protein 4.10 6.69

320032 AI699772 Hs.292664 ESTs, Weakly similar to A46010 X-linked 3.27 3.27

320040 AA233671 Hs.87164 hypothetical protein FLJ14001 1.81 1.64

320047 T86564 Hs.302256 EST 3.38 7.36

320063 AA074108 Hs.120844 FOXJ2 forkhead factor 5.90 16.73

320096 H58138 Hs.117915 ESTs 2.08 4.47

320099 AW411307 Hs.114311 CDC45 (cell division cycle 45, S.cerevis 1.00 1.00

320112 T92107 Hs.188489 ESTs 2.27 2.06

320140 H94179 Hs.119023 SMC2 (structural maintenance of chromoso 1.00 1.00

320188 AW419200 Hs.172318 ESTs 1.26 1.00

320193 AA831259 Hs.17132 ESTs 2.58 6.23

320195 R62203 Hs.24321 Homo sapiens cDNA FLJ12028 fis, clone HE 2.85 4.53

320199 R78659 Hs.29792 ESTs 0.40 0.94

320203 AL049227 Hs.124776 Homo sapiens mRNA; cDNA DKFZp564N1116 (f 0.84 1.18

320219 AA327564 Hs.127011 tubulointerstitial nephritis antigen 1.00 1.17

320220 AF054910 Hs.127111 tektin 2 (testicular) 0.18 1.09

320225 AF058989 Hs.128231 G antigen, family B, 1 (prostate associa 5.26 13.75

320231 H03139 Hs.24683 ESTs 1.59 1.93

320260 NM 003608 Hs.131924 G protein-coupled receptor 65 1.38 4.56

320267 AL049337 Hs.132571 Homo sapiens mRNA; cDNA DKFZp564P016 (fr 1.00 1.92

320268 H06019 Hs.151293 Homo sapiens cDNA FLJ10664 fis, clone NT 5.58 5.70

320322 AF077374 Hs.139322 small proline-rich protein 3 1.41 1.01

320325 AI167978 Hs.139851 caveolin 2 0.05 0.67

320330 AF026004 Hs.141660 chloride channel 2 2.17 1.26

320339 H10807 Hs.281434 Homo sapiens cDNA FLJ14028 fis, clone HE 1.81 2.32

320388 H16065 Hs.31286 ESTs 1.00 3.22

320402 R22291 Hs.23368 Homo sapiens clone FLC0578 PR02852 mRNA, 1.41 1.36

320413 AA203711 Hs.173269 ESTs 2.31 3.61

320432 R62786 Hs.124136 ESTs 11.25 20.78

320436 AA253352 Hs.293663 ESTs 2,22 3.49

320438 W24548 Hs.5669 ESTs 3.53 8.14 320448 AI240233 Hs.80887 v-yes-1 Yamaguchi sarcoma viral related 1.42 3.46

320451 R26944 Hs.180777 Homo sapiens mRNA; cDNA DKFZp564M0264 (f 0.87 0.81

320484 AA094436 Hs.296267 follistatin-like 1 0.65 1.18

320499 R32555 Hs.24321 Homo sapiens cDNA FLJ12028 fis, clone HE 3.44 7.15

320514 AB007978 Hs.158278 KIAA0509 protein 6.44 13,62

320521 N31464 Hs.24743 hypothetical protein FLJ20171 1.48 1.04

320526 AW374205 Hs.111314 ESTs 3.66 7.87

320527 R34672 Hs.324522 ESTs 3.16 5.63

320536 AA331732 Hs.137224 ESTs 2.83 5.83

320556 AF054177 Hs.14570 hypothetical protein FLJ22530 1.28 1.00

320564 AF056209 Hs.159396 peptidylglycine alpha-amidating monooxyg 1.22 0.81

320587 Z44524 Hs.167456 Homo sapiens mRNA full length insert cDN 1.84 2.44

320635 R54159 Hs.80506 small nuclear ribonucleoprotein polypept 1.00 6.25

320639 AA243258 Hs.7395 hypothetical protein FLJ23182 2.60 2.30

320648 N48521 Hs.26549 Homo sapiens mRNA for KIAA1708 protein, 1.00 1.53

320651 AA489268 Hs.111334 ferritin, light polypeptide 0.14 0.79

320664 AI904216 Hs.91251 hypothetical protein FLJ11198 5.02 8.84

320676 AA132650 Hs.300511 ESTs 3.63 5.37

320683 R59291 Hs.26638 ESTs, Weakly similar to unnamed protein 0.37 1.31

320689 AA334609 Hs.171929 ESTs, Weakly similar to A54849 collagen 1.27 1.02

320696 AW135016 Hs.172780 ESTs 3.53 4.60

320714 AI445591 gb:yq04a10.r1 Soares fetal liver spleen 1.06 0.85

320727 U96044 Hs.181125 immunoglobulin lambda locus 1.35 1.49

320771 A1793266 Hs.117176 poly(A)-binding protein, nuclear 1 0.04 0.82

320794 AA281993 Hs.91226 ESTs 2.96 4.33

320822 AF100780 Hs.194679 WNT1 inducible signaling pathway protein 0.10 0.79

320824 AF120274 Hs.194689 artemin 1.16 1.11

320830 AJ132445 Hs.266416 claudin 14 1.06 1.75

320843 AA317372 Hs.34744 Homo sapiens mRNA; cDNA DKFZp547C136 (fr 1.36 1.47

320849 D60031 Hs.34771 ESTs 5.30 7.49

320853 AI473796 Hs.135904 ESTs 1.00 1.00

320896 AB002155 Hs.271580 uroplakin 1B 5.90 2.55

320921 R94038 ^" Hs.199538 inhibin, beta C 2.20 1.17

320927 AI205786 Hs.213923 ESTs 0.18 1.46

320957 AI878933 Hs.92023 core histone macroH2A2.2 1.67 2.18

320997 H22544 gb:yn69f11.r1 Soares adult brain N2b5HB5 3.26 3.62

321045 W88483 Hs.293650 ESTs 2.25 4.55

321046 H27794 Hs.269055 ESTs 2.69 4.25

321052 AW372884 Hs.240770 nuclear cap binding protein subunit 2, 2 2.14 2.56

321059 AI092824 Hs.126465 ESTs 1.69 0.53

321062 R87955 Hs.241411 Homo sapiens mRNA full length insert cDN 2.76 5.20

321067 AF131782 Hs.241438 Homo sapiens clone 24941 mRNA sequence 4.79 7.41

321102 AA018306 gb:ze40d08.r1 Soares retina N2b4HR Homo 1.79 4.27

321130 H43750 Hs.125494 ESTs 1.00 3.14

321142 AI817933 Hs.298351 ASPL protein 8.73 15.36

321155 AA336635 Hs.99598 hypothetical protein MGC5338 3.04 5.03

321158 AA700289 gb:yu76f11.rl Soares fetal liver spleen 4.62 8.39

321170 N53742 Hs.172982 ESTs 2.21 4.46

321199 AW385512 gb:yy56d10.s1 Soares.multiple.sclerosis. 5.69 8.01

321206 H54178 Hs.226469 Homo sapiens cDNA FLJ12417 fis, clone MA 4.00 7.32

321225 AL080073 Hs.251414 Homo sapiens mRNA; cDNA DKFZp564B1462 (f 4.17 4.63

321236 AW371941 Hs.18192 Ser/Arg-relaled nuclear matrix protein ( 1.00 1.00

321244 AF068654 gb:Homo sapiens isolate AN.1 immunoglobu 2.18 9.13

321270 R83560 gb:yv76c06.s1 Soares fetal liver spleen 3.80 5.26

321317 AI937060 Hs.6298 KIAA1151 protein 1.81 1.65

321318 AB033041 Hs.137507 KIAA1215 protein 1.00 1.00

321325 AB033100 Hs.300646 KIAA protein (similar to mouse paladin) 0.44 0.93

321342 AA127984 Hs.222024 transcription factor BMAL2 4.94 4.93

321356 R93443 Hs.271770 ESTs 3.10 4.66

321418 AI739161 Hs.161075 ESTs 2.28 2.54

321420 AI368667 Hs.132743 ESTs 1.13 0.97

321430 U05890 gb:H.sapiens (DIG3) mRNA for immunoglobu 2.42 3.35

321453 N50080 Hs.82845 Homo sapiens cDNA: FLJ21930 fis, clone H 1.60 3.11

321467 X13075 gb:Human 2a12 mRNA for kappa-immunoglobu 0.42 0.72

321468 AA514198 Hs.38540 ESTs 2.46 6.50

321491 H70665 Hs.292549 ESTs 1.00 1.25

321498 AW295517 Hs.255436 ESTs 3.19 6.24

321504 W02356 Hs.268980 ESTs 2.28 3.86

321510 AA703650 Hs.255748 ESTs 2.14 3.94

321513 H84972 Hs.108551 ESTs 2.78 5.37

321516 AI382803 Hs.159235 ESTs 3.06 7.19

321565 AI525773 Hs.266514 hypothetical protein FLJ 11342 4.89 7.82

321577 H84260 gb:ys90g04.r1 Soares retina N2b5HR Homo 1.00 1.73

321581 AA019964 Hs.28803 ESTs 4.88 6.73

321582 AA143755 Hs.21858 trinucleotide repeat containing 3 1.00 2.08

321587 H95531 gb:ys76e02.r1 Soares retina N2b4HR Homo 2.26 4.52

321626 AA295430 Hs.96322 hypothetical protein FLJ23560 1.95 3.83

321628 H87064 Hs.161051 ESTs, Moderately similar to ALU6_HUMAN A 0.47 1.02

321642 AW085917 Hs.247084 ESTs 1.52 1.38

321669 H95404 Hs.294110 ESTs 2.17 2.45

321687 AA625149 gb:af70c12.r1 Soares_NhHMPu_S1 Homo sapi 4.31 6.95

321688 H97646 Hs.123158 Homo sapiens cDNA FLJ12830 fis, clone NT 2.82 3.28

321693 AA700017 Hs.173737 ras-related C3 botulinum toxin substrate 0.51 1.08

321700 N55160 Hs.167260 ESTs 4.57 7.46

321701 AW390923 Hs.42568 ESTs 1.00 1.00 321709 N25847 Hs.108923 RAB38, member RAS oncogene family 1.00 1.00

321710 N35682 Hs.259743 ESTs 2.97 5.26

321775 AI694875 Hs.202312 Homo sapiens cione NII NTera2D1 teratoca 1.00 1.00

321777 AI637993 Hs.202312 Homo sapiens cione NII NTera2D1 teratoca 1.68 0.45

321779 N42729 Hs.163835 ESTs 0.90 0.90

321829 D81993 Hs.8966 tumor endothelial marker 8 2.69 3.89

321846 AA281594 Hs.87902 ESTs 5.11 7.64

321879 AL109670 Hs.302809 ESTs 6.49 9.58

321883 AA426494 Hs.46901 KIAA1462 protein 0.28 0.95

321899 N55158 Hs.29468 ESTs 0.39 0.95

321911 AF026944 Hs.293797 ESTs 6.20 10.76

321949 R49202 Hs.181694 EST 4.62 10.51

321955 AI651866 Hs.195689 ESTs 2.89 5.47

321956 AL110177 Hs.132882 ESTs 0.32 1.25

321987 AL133612 Hs.272759 KIAA1457 protein 1.00 1.83

321991 AL133627 Hs.158923 Homo sapiens mRNA; cDNA DKFZp434K0722 (f 4.00 6.47

322002 AA328801 Hs.84522 ESTs 2.10 3.48

322035 AL137517 Hs.306201 hypothetical protein DKFZp56401278 1.00 1.90

322044 AW340926 gb:xy51b10.x1 NCI_CGAP_Lu34.1 Homosapie 3.20 9.67

322057 N92197 Hs.154679 synaptotagmin 1 1.55 1.07

322060 AI341937 gb:qt10e03.x1 NCI.CGAP.GC4 Homo sapiens 4.59 7.68

322070 U80769 Hs.210322 Homo sapiens mRNA for KIAA1766 protein, 2.78 4.52

322083 AF074982 Hs.226031 ESTs, Highly similar to KIAA0535 protein 3.10 5.52

322091 AI819863 Hs.106243 ESTs 1.59 1.75

322125 R93901 gb:yq16c12.r1 Soares fetal liver spleen 2.06 5.27

322130 R98978 Hs.117767 ESTs 10.12 16.49

322147 AF085919 Hs.114176 ESTs 0.94 0.64

322166 AF085958 gb:yr88b03.r1 Soares fetal liver spleen 4.09 6.67

322173 H52567 gb:yt85d04.r1 Soares_pineal_gland_N3HPG 3.46 4.85

322178 H56535 gb:yt88g03.r1 Soares_pineal_gland_N3HPG 0.44 2.54

322179 H92891 gb:yt94c02.s1 Soares_piπeal_gland N3HPG 4.52 7.50

322186 H67346 Hs.269187 ESTs 0.15 0.98

322196 W87895 Hs.211516 ESTs 2.20 5.04

322212 AF087995 Hs.134877 ESTs 3.42 4.84

322221 AI890619 Hs.179662 nucleosome assembly protein 1-like 1 0.82 2.14

322277 AI640193 Hs.226389 ESTs 3.62 3.98

322278 AF086283 gb:zd46f01.r1 Soares.fetal heart_NbHH19W 1.00 1.00

322284 AI792140 Hs.49265 ESTs 0.66 2.76

322288 AL037273 Hs.7886 pellino (Drosophila) homolog 1 0.71 0.70

322320 AF086419 gb:zd78d03.r1 Soares_fetal_heart_NbHH19W 2.02 2.76

322336 AA308526 Hs.76152 decorin 2.92 4.44

322339 W17348 gb:zb18c07.x5 Soares_fetal_lung_NbHL19W 8.50 11.56

322366 AW404274 Hs.122492 hypothetical protein 0.61 1.34

322372 W25624 Hs.153943 ESTs 7.37 12.07

322374 AI394663 Hs.122116 ESTs, Moderately similar to Osf2 [M.musc 4.78 10.50

322378 AF064819 Hs.201877 DESC1 protein 1.00 1.00

322388 AI815730 Hs.247474 hypothetical protein FLJ21032 7.09 8.49

322416 AA223183 Hs.298442 adaptor-related protein complex 3, mu 1 3.20 5.80

322419 AA248987 Hs.14084 ring finger protein 7 1.64 1.57

322425 W37943 Hs.34892 KIAA1323 protein 0.83 1.00

322431 AA069222 Hs.141892 ESTs 3.96 5.22

322450 AA040131 Hs.25144 ESTs 5.18 12.67

322465 AA137152 Hs.286049 phosphoserine aminotransferase 3.41 2.23

322467 AF116826 Hs.180340 putative protein-tyrosine kinase 1.00 1.30

322473 AA744286 Hs.266935 tRNA selenocysteine associated protein 1.75 2.03

322509 T52172 Hs.302213 ESTs 1.00 2.27

322523 W80398 Hs.193197 ESTs 2.75 5.49

322527 AF147359 gbiHomo sapiens full length insert cDNA 1.25 1.27

322560 AI916847 Hs.270947 ESTs 4.57 8.81

322566 W87285 Hs.269587 ESTs 1.00 1.42

322585 AA837622 gb:zh69c01 ,r1 Soares_fetal_liver_spleen_ 4.18 6.94

322635 AA679084 gb:zh90h08.r1 Soares fetal liver spleen 2.40 4.85

322641 AA007352 Hs.256042 ESTs 2.94 4.64

322653 AI828854 Hs.258538 striatin, calmodulin-binding protein 0.48 0.38

322664 AA011522 gb:zi03g07.r1 Soares_fetal_liver_spleen_ 1.92 2.18

322687 AI110759 gb:AF074666 Human fetal liver cDNA libra 4.14 6.75

322692 AA018117 Hs.60843 potassium voltage-gated channel, shaker- 3.50 5.00

322694 AH 10872 Hs.279812 PRO0327 protein 1.80 1.72

322708 AF113674 Hs.283773 clone FLB1727 1.00 3.43

322712 AA021328 Hs.23607 hypothetical protein FLJ11109 3.28 3.86

322766 AW068805 Hs.288467 Homo sapiens cDNA FLJ12280 fis, clone MA 1.63 1.53

322770 AA045796 Hs.122682 ESTs 1.53 1.06

322794 AI608591 Hs.38991 S100 calcium-binding protein A2 12.06 1.94

322810 AI962276 Hs.127444 ESTs 4.09 6.90

322818 AW043782 Hs.293616 ESTs 1.20 1.63

322820 AI377755 Hs.120695 ESTs 0.21 1.93

322872 AA827228 Hs.126943 ESTs 2.04 1.63

322882 AW248508 Hs.279727 Homo sapiens cDNA FLJ14035 fis, clone HE 5.26 1.22

322887 AI986306 Hs.86149 phosphoinositol 3-phosphate-binding prat 2.80 2.24

322913 AI733737 Hs.68837 ESTs 2.38 6.61

322926 AI825940 Hs.211192 ESTs 4.02 5.79

322929 AI365585 Hs.146246 ESTs 0.30 1.14

322968 AI905228 Hs.83484 SRY (sex determining region Y)-box 4 2.06 1.13

322971 C15953 Hs.212760 hypothetical protein FLJ13649 1.18 2.00

322981 AA493252 Hs.159577 ESTs 2.28 2.61 322988 C18727 Hs.171941 ESTs 0.39 2.00

323003 AI733859 Hs.149089 ESTs 3.28 1.00

323013 AA134042 Hs.191451 ESTs 3.38 5.68

323025 AL157565 Hs.315369 Homo sapiens cDNA: FLJ23075 fis, clone L 0.06 1.10

323032 AW244073 Hs.145946 ESTs 10.18 21.27

323052 R21124 Hs.85573 Homo sapiens DC29 mRNA, complete eds 1.46 1.90

323064 AL119341 Hs.49359 Homo sapiens mRNA; cDNA DKFZp547E052 (fr 3.08 5.64

323098 AI700025 Hs.270471 ESTs 2.31 4.49

323102 AL119913 Hs.163615 ESTs 5.38 11.64

323155 AL135041 gb:DKFZp762K2310_r1 762 (synonym: hmel2) 2.38 5.56

323176 AW071648 Hs.82101 pleckstrin homology-like domain, family 1.06 1.41

323191 AA195600 Hs.301570 ESTs 0.73 1.24

323225 AA205654 Hs.24790 KIAA1573 protein 5.25 11.95

323232 AA148722 Hs.224680 ESTs 0.45 1.35

323266 AW003362 Hs.243886 nuclear autoantigenic sperm protein (his 1.71 1.83

323281 AI697556 Hs.292659 ESTs 1.24 3.21

323283 AA256014 Hs.86682 Homo sapiens cDNA: FLJ21578 fis, clone C 12.68 15.05

323314 AA226310 Hs.191501 ESTs 4.42 9.61

323316 AL134620 Hs.280175 ESTs 2.98 5.93

323334 AI336501 Hs.77273 ras homolog gene family, member A 1.98 3.30

323338 R74219 Hs.23348 S-phase kinase-associated protein 2 (p45 1.62 1.00

323348 AA233056 Hs.191518 ESTs 1.00 1.07

323351 AA704103 Hs.24049 ESTs 1.43 1.68

323359 AA234172 Hs.137418 ESTs 0.34 1.18

323360 AA716061 Hs.161719 ESTs 3.01 3.71

323405 AW139550 Hs.115173 ESTs 1.90 8.81

323420 AI672386 Hs.263780 ESTs 0.29 1.01

323434 AW081455 Hs.120219 ESTs 2.27 1.92

323445 AA253103 Hs.135569 ESTs, Weakly similar to NEUROD [H.sapien 0.43 0.80

323449 AA282865 Hs.284153 Fanconi anemia, complementation group A 3.19 3.85

323492 H00978 Hs.20887 hypothetical protein FLJ 10392 2.70 3.20

323501 AA182461 Hs.84520 ESTs 2.04 3.31

323505 AI652287 gb:EST382593 MAGE resequences, MAGK Homo2.21 3.08

323515 AA282274 Hs.256083 ESTs 2.69 3.40

323541 AI185116 Hs.104613 RP42 homolog 1.20 1.09

323545 AI814405 Hs.224569 ESTs 1.25 1.55

323635 R63117 Hs.9691 Homo sapiens cDNA: FLJ23249 fis, clone C 0.27 0.72

323675 AA984759 Hs.272168 tumor differentially expressed 1 3.70 5.80

323678 AL042121 Hs.20880 ESTs 3.33 5.10

323691 AA317561 Hs.145599 ESTs 1.00 1.00

323693 AW297758 Hs.249721 ESTs 2.01 1.54

323746 AW298611 Hs.12808 MARK 4.11 5.53

323774 AA329806 Hs.321056 Homo sapiens mRNA; cDNA DKFZp586F1322 (f 2.06 3.70

323856 AA355264 Hs.267604 hypothetical protein FLJ 10450 3.42 8.13

323857 T18988 Hs.293668 ESTs 5.97 12.51

323870 AA341774 Hs.129212 ESTs 3.17 4.52

323876 AL042492 Hs.147313 ESTs 0.36 1.00

323885 AA344308 Hs.128427 Homo sapiens BAC clone RP11-335J18 from 2.31 3.33

323911 AL043212 Hs.92550 ESTs 4.38 5.41

323919 AA862973 Hs.220704 ESTs 5.80 10.20

323972 AI869964 Hs.182906 ESTs 3.10 5.14

324005 AA610011 Hs.208021 ESTs 5.34 10.07

324036 AI472078 Hs.303662 ESTs 1.00 5.03

324055 AA528794 Hs.128644 ESTs 0.86 1.00

324063 AW292740 Hs.272813 dual oxidase 1 0.45 0.91

324072 AA381829 gb:EST94855 Activated T-cells I Homo sap 2.82 5.12

324092 AW269931 Hs.202473 Homo sapiens cDNA: FLJ22278 fis, clone H 2.40 2.52

324095 AW377983 Hs.298140 Homo sapiens cDNA: FLJ22502 fis, clone H 1.32 4.30

324129 AI381918 Hs.285833 Homo sapiens cDNA: FLJ22135 fis, clone H 1.40 1.77

324132 AW504860 Hs.288836 hypothetical protein FLJ 12673 4.24 6.21

324214 AA412395 Hs.225740 ESTs 6.96 10.69

324227 AA295552 Hs.28631 Homo sapiens cDNA: FLJ22141 fis, clone H 0.81 0.53

324266 AL047634 Hs.231913 ESTs 2.42 4.05

324275 AA429088 Hs.98523 ESTs 3.62 5.38

324281 AL048026 Hs.124675 ESTs, Weakly similar to T14742 hypotheti 0.14 0.70

324290 AA432032 Hs.304420 ESTs 3.71 4.34

324303 AL118754 gb:DKFZp761P1910 r1 761 (synonym: hamy2) 0.95 0.91

324312 AI198841 Hs.128173 ESTs 4.06 5.91

324325 AL138153 Hs.300410 ESTs 5.88 8.25

324338 AL138357 Hs.145078 regulator of differentiation (in S. pomb 0.87 1.25

324341 AW197734 Hs.99807 ESTs, Weakly similar to unnamed protein 1.28 1.00

324343 AW452016 Hs.293232 ESTs 2.54 3.46

324371 AA452305 Hs.270319 ESTs 5.85 8.36

324382 AW502749 Hs.24724 MFH-amplified sequences witfi leuciπe-ric 0.76 1.64

324384 AA453396 Hs.127656 KIAA1349 protein 2.88 5.69

324385 F28212 Hs.284247 KIAA1491 protein 1.81 1.99

324388 AI924963 Hs.306206 hypothetical protein FLJ 11215 1.00 1.00

324432 AA464510 Hs.152812 ESTs 2.73 2.17

324497 AW152624 Hs.136340 ESTs, Weakly similar to unnamed protein 0.71 1.90

324510 AI148353 Hs.287425 Homo sapiens cDNA FLJ11569 fis, clone HE 1.00 1.00

324580 AA492588 gb;ng99c08.s1 NCI CGAP_Thy1 Homo sapiens 2.18 3.50

324582 AA506935 Hs.132036 ESTs, Weakly similar to ALU1.HUMAN ALU S 5.96 11.36

324633 AA572994 Hs.325489 ESTs 2.92 4.22

324640 AW295832 Hs.134798 ESTs, Moderately similar to TTL MOUSE TU 5.48 11.74

324675 AW014734 Hs.157969 ESTs 0.39 0.73 324699 AW504732 Hs.21275 hypothetical protein FLJ11011 0.93 0.93

324747 AA603532 Hs.130807 ESTs 1.57 1.81

324748 AA657457 Hs.292385 ESTs 1.55 1.34

324801 AI819924 Hs.14553 sterol O-acyltransferase (acyl-Coeπzyme 1.00 6.56

324804 AI692552 gb:wd73f12.x1 NCI CGAP Lu24 Homo sapiens 1.00 7.53

324828 AA843926 Hs.124434 ESTs 2.00 3.25

324855 AW152305 Hs.122364 ESTs 2.74 3.43

324866 AI541214 Hs.46320 Small praline-rich protein SPRK [human, 1.07 0.95

324871 AW297755 Hs.271923 Homo sapiens cDNA: FU22785 fis, clone K 1.68 1.21

324886 AA806794 Hs.131511 ESTs 2.56 5.61

324889 D31010 gb:HUML12147 Human fetal lung Homo sapie 2.20 4.65

324948 AW383618 Hs.265459 ESTs, Moderately similar to ALU2_HUMAN A 5.28 7.05

324953 AI264628 Hs.125428 ESTs 3.37 5.51

324958 AA625076 Hs.132892 protocadherin 20 5.12 9.81

324988 T06997 Hs.121028 hypothetical protein FLJ10549 2.52 1.08

325024 F13254 Hs.78672 laminin, alpha 4 5.24 10.22

325105 H97109 Hs.105421 ESTs 1.00 1.00

325108 AA401863 Hs.22380 ESTs 1.99 2.14

325114 D83901 Hs.315562 ESTs 2.73 3.17

325146 AI064690 Hs.171176 ESTs 1.86 3.41

325149 D61117 Hs.187646 ESTs 0.42 0.93

325187 AI653682 Hs.197812 ESTs 6.50 11.31

325228 6.18 15.76

325235 2.64 4.12

325328 2.87 4.42

325340 0.29 0.33

325367 16.56 24.29

325373 0.63 1.22

325389 0.88 1.05

325436 5.75 14.14

325471 8.46 17.82

325498 3.32 6.42

325557 5.51 8.28

325559 7.48 21.40

325560 4.08 6.25

325569 4.20 5.24

325585 1.10 1.13

325587 1.00 1.00

325597 2.98 13.40

325639 0.78 0.78

325685 0.46 0.66

325686 0.95 1.55

325735 4.48 9.20

325739 0.59 0.88

325740 2.42 6.61

325792 7.88 9.83

325819 4.74 7.18

325883 2.02 2.64

325895 7.78 15.98

325925 2.04 10.60

325932 4.18 7.36

325941 3.66 9.03

325969 0.61 0.80

325971 4.88 7.42

326025 0.55 1.07

326046 7.21 14.72

326099 3.60 5.98

326108 1.27 1.06

326163 3.27 5.70

326165 0.45 1.11

326189 0.13 0.45

326204 5.60 9.00

326230 7.00 12.01

326274 1.00 8.09

326360 9.86 15.35

326393 0.52 0.77

326505 1.00 1.42

326515 1.24 5.84

326589 9.20 13.49

326592 2.77 4.01

326605 2.01 2.53

326692 1.00 1.00

326693 1.00 1.31

326720 0.19 0.65

326742 2.34 7.20

326770 0.25 0.83

326818 3.09 4.56

326936 2.08 3.45

326964 0.41 1.70

326983 2.02 3.80

326991 1.09 1.20

327036 1.00 8.04

327040 3.05 4.22

327053 3.55 6.31

327075 1.59 1.40 327085 2.50 12.57 327130 5.38 8.04 327156 3.74 6.58 327220 1.28 1.54 327224 6.56 12.91 327288 2.61 5.40 327321 2.42 3.11 327332 6.62 10.58 327361 2.69 4.41 327377 2.04 6.72 327396 2.61 4.50 327414 1.00 8.01 327442 5.91 9.65 327467 6.58 18.01 327473 3.79 7.48 327483 4.08 8.87 327562 0.68 2.86 327568 1.00 2.00 327606 2.06 3.61 327611 5.90 14.26 327642 4.06 8.74 327654 1.05 2.08 327734 1.00 1.00 327775 1.46 11.79 327796 3.47 5.65 327840 3.26 6.64 327940 5.84 15.58 327984 0.36 1.50 328004 1.87 1.42 328021 0.42 0.59 328068 2.83 4.68 328100 3.04 5.39 328101 3.54 5.20 328113 0.72 0.91 328157 5.58 5.16 328196 ..5.76 11.13 328197 5.98 10.58 328264 3.11 4.88 328299 2.20 3.06 328342 1.49 1.94 328365 1.00 1.00 328369 4.40 7.36 328381 1.86 4.93 328451 5.51 7.56 328481 0.13 0.72 328500 2.71 3.97 328530 5.41 7.62 328600 3.14 10.68 328608 4.56 8.17 328616 2.24 11.91 328623 3.04 5.46 328632 0.70 1.19 328664 3.48 6.80 328666 10.42 26.47

9.68 14.56

328700 2.74 10.22 328708 0.15 0.57 328735 6.23 8.91 328743 3.62 6.54 328806 0.22 0.78 328861 3.68 10.54 328908 5.42 16.36 328933 2.02 5.29 328934 1.73 4.45 328949 3.34 5.41 329005 2.88 7.26 329011 2.52 3.72 329033 1.00 1.03 329037 5.07 8.16 329067 1.98 2.41 329134 2.24 3.25 329157 2.30 11.04 329178 2.64 5.02 329192 6.41 15.27 329194 0.31 0.79 329204 1.60 3.75 329224 2.99 6.11 329228 0.83 0.83 329288 0.63 1.01 329337 1.00 1.00 329541 0.76 1.68 329560 1.34 2.02 329588 1.68 2.22 329643 4.18 11.77 329703 1.00 1.00 329764 578 1550

329816 . 209 544

329860 3 13 1077

329993 783 1421

330020 558 13 12

330036 332 557

330052 431 797

330085 1 34 1 76

330088 470 1246

330093 044 1 06

330100 347 483

330106 214 3 61

330107 317 687

330120 561 11 89

330123 450 1274

330208 1 55 762

330263 13 10 23 38

330300 281 498

330313 300 441

330366 0 67 076

330372 476 11 82

330385 AA449749 Hs 182971 karyopherm alpha 5 (importm alpha 6) 2 14 215

330397 D14659 Hs 154387 KIAA0103 gene product 040 1 15

330468 L10343 Hs 112341 protease inhibitor 3, skin derived (SKAL 1 11 094

330472 L24203 Hs 82237 ataxia telangiectasia group D-associated 1 67 1 17

330478 L38486 Hs 296049 microfibrillar-associated protein 4 046 1 07

330493 M27826 Hs 267319 endogenous retroviral protease 1 07 095

330495 M31328 Hs 71642 guanine nucleotide binding protein (G pr 097 096

330506 M61906 Hs 6241 phosphoιnosιtιde-3 kmase, regulatory su 0 17 366

330512 M80563 Hs 81256 S100 calcium-binding protein A4 (calcium 060 1 06

330537 U19765 Hs 2110 zinc finger protein 9 (a cellular retrov 281 207

330547 U32989 Hs 183671 tryptophan 2,3-dιoxygenase 391 1 49

330551 U39840 Hs 299867 hepatocyte nuclear factor 3, alpha 1 15 1 03

330568 U56244 (NONE) 283 479

330599 U90437 gb Human RP1 homolog mRNA, 3 UTR region 208 1 54

330601 U90916 Hs 82845 Homo sapiens cDNA FLJ21930 fis, clone H 089 1 35

330605 X02419 Hs 77274 plasminogen activator, urokmase 1 87 1 55

330609 X04741 Hs 76118 ubiquitm carboxyl terminal esterase L1 1 83 1 30

330617 X53587 Hs 85266 integnn, beta 4 1 54 1 15

330630 X78669 Hs 79088 reticulocalbm 2, EF-hand calcium bindm 1 39 1 19

330644 Y07755 Hs 38991 S100 calcium binding protein A2 383 1 13

330650 Z68228 Hs 2340 junction plakoglobm 1 25 095

330660 AA347868 Hs 139293 ESTs, Weakly similar to ALU7JHUMAN ALU S 1550 2907

330692 AA017045 Hs 6702 ESTs 1 00 1 00

330707 AA133891 Hs 293690 ESTs 020 1 35

330715 AA233707 Hs 11571 Homo sapiens cDNA FLJ11570 fis, clone HE 012 1 40

330717 AA233926 Hs 52620 integnn, beta 8 6 62 542

330722 AA243560 Hs 34382 ESTs 1 40 1 65

330740 AA297746 Hs 22654 Homo sapiens voltage gated sodium channe 027 204

330742 AA400979 Hs 25691 receptor (calcitonin) activity modifying 044 090

330744 AA406142 Hs 12393 dTDP-D-glucose 4,6 dehydratase 071 323

330751 AA428286 Hs 29643 Homo sapiens cDNA FLJ 13103 fis, clone NT 1 66 1 52

330760 AA448663 Hs 30469 ESTs 052 090

330763 AA450200 Hs 274337 hypothetical protein FLJ20666 037 097

330786 D60374 Hs 49136 ESTs, Moderately similar to ALU7 HUMAN A 078 084

330790 T48536 Hs 105807 ESTs 023 317

330814 AA015730 Hs 265398 ESTs, Weakly similar to transformation-r 037 207

330827 AA040332 Hs 12744 ESTs 1 60 1 00

330844 AA063037 Hs 66803 ESTs 093 1 16

330901 AA157818 Hs 267319 endogenous retroviral protease 1 02 1 03

330931 F01443 Hs 284256 hypothetical protein FLJ 14033 similar to 024 088

330952 H02855 Hs 29567 ESTs 0 08 1 31

330961 H10998 Hs 164 a disintegrin and metalloproteinase doma 1 29 1 26

330968 H16568 Hs 23748 ESTs 048 096

331014 H98597 Hs 30340 hypothetical protein KIAA1165 0 29 074

331046 N66563 Hs 191358 ESTs 099 856

331060 N75081 Hs 157148 Homo sapiens cDNA FLJ11883 fis, clone HE 1 24 1 00

331099 R36671 Hs 83937 hypothetical protein 075 1 03

331108 R41408 Hs 21983 ESTs 1 00 275

331131 R54797 gb yg87b07 s1 Soares infant brain 1NIB H 6 04 1068

331135 R61398 Hs 4197 ESTs 080 096

331170 T23461 Hs 159293 ESTs 263 429

331180 T32446 Hs 6640 Human DNA sequence from PAC 75N13 on chr 1 78 271

331183 T40769 Hs 8469 ESTs 1 00 301

331203 T82310 (NONE) 1 70 380

331271 AA059347 Hs 82226 glycoprotem (transmembrane) nmb 1 20 319

331306 AA252079 Hs 63931 dachshund (Drosophila) homolog 031 1 30

331327 AA281076 Hs 109221 ESTs 2 09 241

331341 AA303125 Hs 23240 Homo sapiens cDNA FLJ13496 fis, clone PL 072 243

331359 AA416979 Hs 46901 KIAA1462 protein 009 091

331363 AA421562 Hs 91011 anterior gradient 2 (Xenepus laevis) horn 1 02 087

331378 AA448881 Hs 49282 hypothetical protein FLJ11088 1 03 1 23

331384 AA456001 Hs 93847 NADPH oxidase 4 1 40 1 00

331402 AA505135 Hs 44037 ESTs 1 80 393

331422 F10802 Hs 163628 ESTs, Moderately similar to ALU7_HUMAN 1 65 1 89 331490 N32912 Hs 26813 CDA14 248 1 73

331531 N51343 gb yz15g04 s1 Soares_multιple_sclerosιs_ 098 1 68

331547 N54811 gb od74f04 s1 NCI CGAP Ov2 Homo sapiens 3 80 575

331578 N67960 Hs 249989 ESTs 011 067

331589 N71027 Hs 152618 ESTs 1 09 1 38

331608 N89861 Hs 112110 PTD007 protein 0 93 076

331614 N92293 Hs 240272 EST 017 1 34

331668 W69707 Hs 58030 EST 224 382

331671 W72033 Hs 194695 ras homolog gene family, member I 1 00 1 24

331676 W79834 Hs 58559 ESTs, Weakly similar to rhotekin [M muse 008 1 07

331681 W85712 Hs 119571 collagen, type III, alpha 1 (Ehlers-Danl 872 427

331692 W93592 Hs 152213 wingless type MMTV integration site fami 0 94 054

331717 AA190888 Hs 153881 Homo sapiens NY-REN-62 antigen mRNA, par 1 57 1 34

331718 AA191404 Hs 104072 ESTs 680 11 77

331811 AA404500 Hs 301570 ESTs 1 10 1 00

331820 AA405970 Hs 97996 transcription termination factor, mitoc 073 059

331831 AA412031 Hs 97901 EST 277 408

331852 AA418988 Hs 98314 Homo sapiens mRNA, cDNA DKFZp586L0120 (f 023 093

331943 AA453418 Hs 21275 hypothetical protein FLJ 11011 036 1 88

331969 AA460702 Hs 82772 collagen, type XI, alpha 1 1 00 1 00

331990 AA478102 Hs 139631 ESTs 304 3 87

332002 AA482009 Hs 105104 ESTs 1 19 078

332027 AA489671 Hs 65641 hypothetical protein FLJ20073 1 27 1 03

332029 AA489697 Hs 145053 ESTs 030 1 62

332033 AA489840 Hs 251014 EST 230 370

332048 AA496019 Hs 201591 ESTs 0 17 052

332071 AA598594 Hs 205293 KIAA1211 protein 1 35 1 23

332074 AA599012 gb ae41e11 s1 GesslerWilms tumor Homos 019 200

332083 AA600200 Hs 155546 KIAA1080 protein, Golgi-associated, gamm 031 1 18

332085 AA600353 Hs 173933 nuclear factor l/A 0 30 1 50

332125 AA609861 Hs 312447 ESTs 0 22 062

332177 F10812 Hs 101433 ESTs 821 1803

332180 H03348 Hs 7327 claudin 1 227 1 57

332185 H10356 Hs 101689 ESTs 009 1 18

332203 H49388 Hs 317769 EST 805 502

332232 N48891 Hs 101915 Stargardt disease 3 (autosomal dominant) 078 085

332240 N54803 Hs 324267 ESTs, Weakly similar to putative p150 [ 0 96 1 23

332261 N70294 Hs 269137 ESTs 240 374

332275 R08838 Hs 26530 serum deprivation response (phosphatidyl 0 27 075

332280 R38100 Hs 146381 RNA binding motif protein, X chromosome 0 39 1 88

332299 R69250 Hs 21201 πectin 3, DKFZP566B0846 protein 524 1276

332304 R74041 Hs 101539 ESTs 1 44 318

332314 T25862 Hs 101774 hypothetical protein FLJ23045 0 68 1 32

332384 M11433 Hs 101850 retmol binding protein 1, cellular 1 71 088

332434 N75542 Hs 289068 Homo sapiens cDNA FLJ11918 fis, clone HE 043 086

332445 T63781 Hs 11112 ESTs 068 1 00

332453 L00205 Hs 111758 keratin 6A 31 54 1 00

332458 M33493 Hs 250700 tryptase beta 1 051 1 00

332504 AA053917 Hs 15106 chromosome 14 open reading frame 1 079 1 24

332525 M17252 Hs 278430 cytochrome P450, subfamily XXIA (steroid 098 1 70

332530 M31682 Hs 1735 inhibin, beta B (activm AB beta polypep 088 066

332535 N20284 Hs 19280 cysteine-πch motor neuron 1 022 1 46

332539 AA412528 Hs 20183 ESTs, Weakly similar to AF164793 1 prate 093 1 49

332559 M13955 Hs 166189 cytokeratin 2 035 1 13

332563 N92924 Hs 274407 protease, serine, 16 (thymus) 1 00 1 00

332565 AA234896 Hs 25272 E1A binding protein p300 036 1 05

332594 AA279313 Hs 3239 methyl CpG binding protein 2 (Rett syndr 053 059

332634 S38953 Hs 283750 teπascm XA 038 1 16

332638 AA283034 Hs 50640 JAK binding protein 1 00 1 70

332640 AA417152 Hs 5101 protein regulator of cytokinesis 1 615 1 16

332654 AA001296 Hs 288217 hypothetical protein MGC2941 1 50 273

332665 AA223335 Hs 63788 propionyl Coenzyme A carboxylase, beta p 1 20 091

332692 AA496035 Hs 247926 gap junction protein, alpha 5, 40kD (con 017 1 12

332716 L00058 Hs 79070 v myc avian myelocytomatosis viral oncog 1 00 1 44

332736 L13773 Hs 114765 myeloid/lymphoid or mixed lineage leukem 1 00 1 81

332758 X93921 Hs 296938 dual specificity phosphatase 7 053 078

332781 AA233258 Hs 247112 hypothetical protein FLJ 10902 1 44 1 56

332792 1 70 1 19

332816 1 85 247

332858 1 04 1 57

332906 348 804

332911 1 00 1 00

332912 1 06 440

332922 1 00 1 00

332956 042 088

332959 1 96 634

332982 056 099

332984 030 078

332998 1 47 201

333058 047 1 38

333097 214 3 19

333121 276 370

333122 1 92 1 21

333123 1 85 1 39

333138 047 052 333139 1.88 0.84

333140 0.21 0.64

333221 1.51 1.11

333260 0.75 1.01

333380 6.68 15.75

333387 4.56 12.61

333512 5.05 8.01

333524 2.28 3.98

333585 2.31 1.53

333603 2.23 1.17

333604 2.51 1.58

333618 0.52 0.98

333627 1.44 1.36

333628 1.90 1.90

333650 1.85 2.10

333678 1.85 2.35

333750 2.18 5.67

333763 1.99 2.60

333767 1.02 0.96

333768 1.78 1.65

333769 2.15 2.13

333772 1.46 2.53

333777 1.00 1.42

333846 2.99 4.50

333884 0.47 0.94

333887 0.50 1.00

333891 0.43 0.89

333892 0.51 0.91

333904 0.26 1.13

333906 0.55 0.98

333948 1.70 2.15

333954 0.37 1.09

333966 8.10 14.30

333968 0.63 1.38

334061 4.24 12.30

334094 1.30 12.03

334113 4.55 8.63

334161 0.82 1.59

334183 0.47 0.76

334187 1.36 3.70

334219 0.69 1.04

334222 1.88 1.70

334223 4.72 3.14

334239 0.79 0.62

334255 0.45 1.10

334333 1.00 3.56

334378 3.98 5.76

334382 1.50 1.31

334492 3.59 4.75

334562 5.94 15.40

334588 8.14 19.53

334616 1.55 1.56

334633 5.16 8.07

334648 0.59 2.13

334787 3.70 7.15

334866 8.13 10.60

334891 0.32 1.14

334933 1.00 3.84

334934 4.01 7.43

334945 1.04 2.96

334967 0.29 1.14

334990 1.50 1.39

335015 5.88 18.65

335093 0.55 1.75

335120 4.31 8.01

335125 0.38 1.97

335179 1.24 1.98

335188 0.46 1.47

335211 1.61 1.42

335288 0.73 0.97

335289 0.20 0.26

335361 2.18 1.58

335379 0.50 0.71

335414 3.64 14.94

335416 2.93 3.98

335496 0.96 0.91

335497 1.71 1.92

335548 1.15 2.40

335551 3.22 10.54

335558 3.42 4.89

335586 5.50 12.75

335619 2.99 3.07

335620 3.80 8.29

335621 0.28 0.57

335682 0.46 1.17 335686 2.55 3.81

335755 2.24 1.07

335784 0.20 0.97

335814 1.13 1.48

335815 2.45 3.51

335823 1.00 4.16

335835 0.49 1.70

335851 1.66 1.39

335868 2.98 6.43

335896 0.96 0.99

335936 12.10 21.93

335948 1.00 1.64

335983 1.00 4.21

335995 0.37 1.17

336021 1.04 0.84

336034 11.40 23.54

336038 1.19 1.21

336066 0.54 1.63

336107 0.95 0.70

336205 3.13 6.29

336275 3.20 10.10

336292 2.34 3.09

336331 1.00 1.00

336419 0.65 0.79

336632 2.33 2.16

336633 2.55 2.23

336634 2.19 2.03

336635 2.69 2.48

336636 2.13 1.83

336637 2.43 2.24

336638 2.31 2.03

336659 0.60 1.31

336675 0.31 1.18

336684 1.50 1.14

336694 4.74 7.10

336716 4.43 6.37

336721 2.20 0.74

336798 1.64 2.14

336900 6.14 12.73

336948 1.00 1.00

337028 1.30 2.09

337043 4.01 11.53

337046 1.67 1.84

337054 2.78 7.35

337128 7.20 16.14

337162 3.45 5.34

337183 5.72 11.41

337184 3.72 5.90

337192 1.27 1.06

337194 1.88 1.68

337229 0.22 1.03

337268 1.00 3.31

337299 3.23 5.14

337325 2.76 3.72

337389 5.80 10.42

337493 2.06 6.30

337497 7.88 20.29

337500 3.80 4.48

337549 1.66 2.31

337603 1.27 8.54

337605 5.76 7.16

337671 0.73 0.97

337755 1.54 0.92

337786 5.07 9.73

337809 6.18 12.87

337862 3.78 12.97

337871 2.66 8.16

337958 0.26 1.34

338008 1.48 1.12

338033 2.38 14.59

338083 0.65 2.16

338110 1.00 1.61

338112 5.86 8.25

338145 1.70 1.97

338148 8.07 18.19

338158 1.30 4.55

338161 2.58 3.57

338179 1.00 1.00

338182 3.32 4.63

338189 1.00 3.34

338197 0.99 1.69

338199 4.58 7.62

338215 6.01 15.85

338279 0.53 0.95

338316 20.58 38.66 338322 3.23 7.39 338357 4.10 11.39 338359 10.12 21.59 338366 0.69 1.02 338374 0.40 1.18 338414 0.47 1.06 338418 6.12 13.86 338469 3.09 5.11 338501 6.28 10.32 338506 6.97 12.41 338523 3.10 5.84 338549 1.70 2.70 338561 0.79 0.81 338662 1.72 1.46 338671 0.17 0.91 338676 2.10 ^' 15.86 338726 1.20 1.09 338779 0.12 0.57 338804 0.99 1.67 338836 1.00 1.00 338871 4.30 9.81 338872 5.02 12.81 338879 0.23 1.12 338937 6.55 12.26 338966 1.76 5.42 338993 1.00 2.40 339047 5.26 10.81 339100 5.10 6.88 339114 1.00 1.70 339121 1.00 3.75 339170 10.36 19.67 339229 4.08 13.48 339264 2.64 3.83 339293 1.73 1.94

TABLE 8B shows the accession numbers for those Pkeys in Table 8A lacking unigenelD's. For each probeset we have listed the gene cluster number from which the oligonucleotides were designed. Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs. These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California). The Genbank accession numbers for sequences comprising each cluster are listed in the "Accession" column.

Pkey: Unique Eos probeset identifier number

CAT number: Gene cluster number Accession: Genbank accession numbers

Pkey CAT number Accessions

322044 187363 1 AW340926 AA249063 N86075

322060 44320 1 AI341937 AW003063 U34725 AA904742

321430 42705 1 X57414 X57415

321467 43034 1 X13075 X13076

322125 46779 1 R93901 AF075073 R93902

322166 46861 1 H69434AF085958 H69846

322173 46873 1 H52567 H52557 AF085970 H52164

322178 46882 1 H56535 AF085980 H56712

322179 46885 1 H92891 AF085982 H92777

321577 1615102 1 H84849 H84252 H84260 H86664 H85320

321587 1615333 1 H95531 H95521 H84529

313723 111953 1 AA070412 AA102346 AA081885

320997 627492 1 H22544 H46842 AI204929

322278 47271 1 W69304AF086283 W69200

321687 218439 1 AA625149 AA313030 AA313052 H97463

313883 129439 1 AA665089 AA135130 AA484059 AA102419 AW877765

322320 47422 1 W79150 AF086419

322339 814584 1 AI668646 AI734214 W17348

314648 293660 1 AW979268 AA878419 AA431342 AA431628

300201 682222 1 AI308300 AI308296

306897 25196 -2 AI093967

323155 979809 1 AL120701 AL135041 AL121524

322527 38927 1 AF147359 T58511 T58560

322585 473768 2 W88919 W89125

300362 1574395 1 Z42308 H23514

322635 82296 1 AA005129 AA679084 AA694399

322664 85042J AA011522 AA702841 AA011691 AA330797

315454 380580 1 AI239464 AI239473 AA625812 AI208703

322687 37372 1 AF074666 Al 110759 AF090902

314852 327472 1 AI903735 AA491283 AI694953 AW976903 AA761362

307783 697809 1 AI347274AW844024

324072 269032 1 AA381722 AA381829 AW963906 AW963902 AA381242

300627 221345 1 AA488472 W27363 AA317053 BE082689 AW967036 BE079872

323505 196389 1 AW970512 AA280251 AI652287 BE466438 AI650725 AA551854 AA281574 A 571481

315791 403558 1 AA678177 AA677034

324303 233842 1 AL118754 AA333202 H38001

316519 442885 1 AA847835 AA768376

300926 333127_1 AA504860 AA504911 324580 328264 AA492588 AA492498 AA492571

301882 275087J T78054T79888AA398185

324804 398093J AI692552 AI393343 AI800510 AI377711 F24263 AA661876

324889 1515978J D31010D30991 D31168 D31166 D31465

302697 432191 AJ001409AJ001410

302711 454191 L08442 D51348

302742 45839 L12061

318499 3644301 T25451AA585296AA585305

310624 346244 U88896 U88898AA916056T03285AI341594AI359534AI634031 U88897

302847 458105 X98941 X98942X98943 X98953 X98949

304122 77271 -5 H28966

303598 2702831 AA382814 AA402411 AA412355

311409 8372641 AI698839 AI909260 AI909259

312094 797889J Z78390T97427

319312 15401161 Z45481 F12393T74437

319407 1688823J R05329 R01555 R08276

319425 16895711 T82930 R02424T85145

320007 229683J AA336314 T82938 AA327744 AW967388 AA639967 T10753

320018 1815987J T83263 T85731 T85730

319484 1691553J T91772 R07257 R07098

318865 15359371 H10818 F07831 Z43072

312220 1671607J N74613T98756T98589

319546 243305J R09692 R09414AA346353

312389 902067 AI863140 W80703 R43474

319611 1566863J H14957 R56522 R11908

312437 291472J BE080180 AW827313 AW231970 AA995028 AA428584 AW872716 AW892508 AW854593 AA578441 AW975234 AA664937 AA984131

AA528743 AA552874 AA564758 AW063245 AI267534 AW070190 AW893483 AA770330 AA906928 AA906582 AA758746 AA551717

AW063311 AA429538

311896 579192J AW206447 AI248530 AI084433 AI400976 R16553

319834 112523J AA071267 T65940 T64515 AA071334

321102 805311 AA018306 H38925AA001221

321158 410938 H79670 H47798 AA700289

321199 212379J N34524 AA305071 AW954803 AA502335 AI433430 AI203597 AW026670 AW265323 AW850787 AA317554 AW993643 AW835572

AW385512 AI334966 W32951 H62656 H53902 R88904 AW835732

305528 28832_-3 AA769156

321270 1662057J N59537 N78278 R83560

314126 177666J AA226431 AA226569 AA488748

320714 743644J R91883AI445591

306442 AA976899

306446 AA977348

306458 AA978186

306510 AA988546

306557 AA994530

306572 AA995686

306582 AA996248

306656 AI004024

306686 AI015615

306751 AI032589

308011 AI439473

306892 AI092465

308106 AI476803

308154 AI500600

306956 AI125111

306958 AI125152

308213 AI557041

308216 AI557135

308219 AI557246

308588 AI718299

308599 ^' A1719893

308643 AI745040

308673 AI760864

308697 A1767143

308778 AI811109

308808 AI818289

308875 AI832332

308886 AI833240

308898 AI858845

308966 AI870704

308979 AI873111

303011 416891 AF090405 AF090407 AF090406

303077 44060J AF163305 AF163307 AF163303

305016 AA626876

305034 AA630128

305072 AA641012

305148 AA654070

305190 AA665955

303978 AW513315

303990 AW515465

303998 AW516449

303999 AW516611

305235 AA670480

305312 AA700201

305413 AA724659

305447 AA737856

321244 29327J AF068654 AF068656 AF068655 305614 AA782866

305637 AA806124

305639 AA806138

305650 AA807709

305690 AA813477

305728 AA828209

305759 AA835353

305792 AA845256

307041 AI144243

307091 AI167439

307181 AI189251

305901 AA872968

305910 AA875981

307415 AI242118

307426 AI243364

307517 AI275055

307551 AI281556

307561 AI282207

307608 AI290295

307691 AI318285

307730 AI336092

307760 AI342387

307764 AI342731

307796 AI350556

309045 AI910902

309051 AI911975

307807 AI351799

307808 AI351826

307820 AI355761

307852 AI365541

309122 AI928178

309164 AI937761

309177 AI951118

307902 AI380462

309299 AW003478

309303 AW004823

309476 AW129368

309532 AW151119

309747 AW264889

309769 AW272346

309799 AW276964

309866 AW299916

302679 311853J H65022AA186889

309923 AW340684

309928 AW341418

309931 AW341683

309933 AW341936

302705 31765 1 U09060 U09061

302789 34161 AJ245067 AJ245070

304006 AW517947

304024 T03036

304026 T03160

304028 T03266

304046 T54803

304061 T61521

304063 T62536

302802 34487 Y08250Y08245

304114 R78946

304155 H68696

304203 N56929

304234 W81608

304348 AA179868

304430 AA347682

304456 AA411240

304521 AA464716

304526 AA476427

304607 AA513322

304735 AA576453

304760 AA580401

306015 AA897116

306063 AA906316

306065 AA906725

306104 AA910956

306109 AA911861

306242 AA932805

306288 AA936900

306396 AA970223

330568 N0T_FOUND entrez U56244

330599 15323 -12 U90437

331131 genbank_R54797 R54797

331203 NOT_FOUND_entrez T82310

331531 genbaπk_N51343 N51343

331547 467396J AA828597 N54811

332074 genbank_AA599012 AA599012 TABLE 8C shows the genomic position for those Pkeys in Table 8A lacking unigene ID's and accession numbers. For each predicted exon, we have listed the genomic sequence source used for prediction. Nucleotide locations of each predicted exon are also listed.

Pkey: Unique number corresponding to an Eos probeset

Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. "Dunham I. et al." refers to the publication entitled The DNA sequence of human chromosome 22." Dunham I. et al., Nature (1999) 402:489495. Strand: Indicates DNA strand from which exons were predicted.

N position: Indicates nucleotide positions of predicted exons.

Pkey Ref Strand Nt_position

332792 Dunham, I. et.al. Plus 73381-73768 332816 Dunham, I. et.al. Plus 359844-360030 332906 Dunham, I. etal. Plus 1923101-1923205 332911 Dunham, I. et.al. Plus 1961767-1961858 332912 Dunham, I. et.al. Plus 1962120-1962246 332922 Dunham, I. etal. Plus 2009620-2009738 332956 Dunham, I. et.al. Plus 2510528-2510658 332959 Dunham, I. etal. Plus 2518145-2518213 333138 Dunham, I. et.al. Plus 3369205-3369323 333139 Dunham, I. etal. Plus 3369495-3369571 333221 Dunham, I. et.al. Plus 3978070-3978187 333380 Dunham, I. et.al. Plus 4904775-4904846 333387 Dunham, I. etal. Plus 4910935-4910997 333512 Dunham, 1. et.al. Plus 5560510-5560564 333524 Dunham, I. etal. Plus 5612620-5612780 333585 Dunham, I. et.al. Plus 6234778-6234894 333618 Dunham, I. etal. Plus 6562391-6562566 333627 Dunham, I. etal. Plus 6620584-6620903 333628 Dunham, I. et.al. Plus 6629004-6629233 333650 Dunham, I. etal. Plus 6796852-6797128 333678 Dunham, I. etal. Plus 7068223-7068288 333750 Dunham, I. etal. Plus 7608165-7608234 333763 Dunham, I. etal. Plus 7692491-7692630 333767 Dunham, I. etal. Plus 7694407-7694623 333768 Dunham, I. etal. Plus 7695440-7695697 333769 Dunham, I. etal. Plus 7696625-7696707 333772 Dunham, I. etal. Plus 7706773-7706902 333777 Dunham, I. etal. Plus 7746805-7746916 333846 Dunham, I. et.al. Plus 8008623-8008757 333884 Dunham, I. etal. Plus 8153960-8154161 333887 Dunham, I. etal. Plus 8154882-8155025 333891 Dunham, I. et.al. Plus 8156437-8156709 333892 Dunham, I. etal. Plus 8156825-8157001 333948 Dunham, I. etal. Plus 8583497-8583627 333954 Dunham, I. etal. Plus 6563186-6563335 333966 Dunham, I. etal. Plus 8655643-8655826 333968 Dunham, I. etal. Plus 8681004-8681241 334061 Dunham, I. etal. Plus 9686941-9687077 334094 Dunham, I. etal. Plus 9889953-9890105 334113 Dunham, I. etal. Plus 10282459-10282597 334161 Dunham, I. etal. Plus 10599033-10599180 334219 Dunham, I. etal. Plus 12716160-12716384 334239 Dunham, I. etal. Plus 13056569-13056693 334333 Dunham, I. etal. Plus 13603544-13603657 334378 Dunham, I. etal. Plus 13907239-13907370 334382 Dunham, I. etal. Plus 13915866-13916036 334562 Dunham, I. etal. Plus 14987847-14987940 334588 Dunham, I. et.al. Plus 15032740-15032817 334616 Dunham, I. etal. Plus 15176123-15176470 334633 Dunham, I. etal. Plus 15333206-15333305 334866 Dunham, I. etal. Plus 18872214-18872317 334891 Dunham, I. etal. Plus 19299770-19299944 334934 Dunham, I. etal. Plus 20103970-20104058 335015 Dunham, I. etal. Plus 20682792-20682945 335120 Dunham, I. etal. Plus 21436286-21436384 335125 Dunham, I. etal. Plus 21441390-21441471 335179 Dunham, I. etal. Plus 21634405-21634526 335188 Dunham, I. etal. Plus 21669118-21669328 335211 Dunham, I. etal. Plus 21774611-21774680 335361 Dunham, I. etal. Plus 22807292-22807445 335379 Dunham, I. etal. Plus 22899306-22899420 335414 Dunham, I. etal. Plus 23235546-23235684 335416 Dunham, I. etal. Plus 23237354-23237465 335496 Dunham, 1. etal. Plus 24164386-24164545 335497 Dunham, I. etal. Plus 24167666-24167869 335558 Dunham, I. etal. Plus 24740167-24740347 335586 Dunham, I. etal. Plus 24990333-24990497 335686 Dunham, I. etal. Plus 25439839-25439920 335784 Dunham, I. etal. Plus 25942710-25942792 335823 Dunham, I. etal. Plus 26365925-26366004 335983 Dunham, I. etal. Plus 27938968-27939070 335995 Dunham, I. etal. Plus 28009044-28009184 336021 Dunham, I. etal. Plus 28686482-28686559 336034 Dunham, I. et.al. Plus 29014404-29014590

336038 Dunham, I. et.al. Plus 29022963-29023165

336107 Dunham, I. etal. Plus 29987731-29987869

336632 Dunham, I. et.al. Plus 983890-985529

336633 Dunham, I. et.al. Plus 985591-986221

336634 Dunham, I. etal. Plus 986296-986670

336635 Dunham, I. etal. Plus 987908-988364

336636 . Dunham, I. etal. Plus 988418-989185

336637 Dunham, I. et.al. Plus 989276-990813

336638 Dunham, I. et.al. Plus 991906-993240

336659 Dunham, I. et.al. Plus 1896402-1896478

336694 Dunham, I. et.al. Plus 2420546-2420616

336721 Dunham, I. et.al. Plus 3371522-3371586

336900 Dunham, I. etal. Plus 10236423-10236523

336948 Dunham, I. et.al. Plus 12692290-12692381

337028 Dunham, I. et.al. Plus 16644817-16644942

337054 Dunham, I. et.al. Plus 17821742-17821922

337162 Dunham, I. etal. Plus 23478943-23479145

337183 Dunham, I. etal. Plus 23943606-23943696

337184 Dunham, I. et.al. Plus 23973949-23974016

337268 Dunham, I. et.al. Plus 28011979-28012034

337299 Dunham, I. etal. Plus 29022656-29022775

337389 Dunham, I. et.al. Plus 31401509-31401579

337493 Dunham, I. et.al. Plus 33330760-33330981

337549 Dunham, I. etal. Plus 34474472-34474531

337755 Dunham, I. et.al. Plus 3971764-3971900

337809 Dunham, I. et.al. Plus 4449069-4449193

337871 Dunham, I. et.al. Plus 5443027-5443101

337958 Dunham, I. etal. Plus 6969162-6969270

338008 Dunham, I. et.al. Plus 7697068-7697236

338033 Dunham, I. et.al. Plus 8092128-8092271

338110 Dunham, I. etal. Plus 10384481-10384621

338112 Dunham, I. et.al. Plus 10391398-10391600

338145 Dunham, I. et.al. Plus 11386629-11386692

338148 Dunham, I. etal. Plus 11448985-11449085

338179 Dunham, I. et.al. Plus 12808775-12808833

338197 Dunham, I. et.al. Plus 13638107-13638181

338279 Dunham, I. et.al. Plus 16168944-16169091

338316 Dunham, I. etal. Plus 17089711-17089988

338322 Dunham, I. et.al. Plus 17132477-17132547

338357 Dunham, I. et.al. Plus 18062184-18062402

338359 Dunham, I. et.al. Plus 18074402-18074501

338366 Dunham, I. et.al. Plus 18252026-18252189

338374 Dunham, I. et.al. Plus 18371200-18371282

338414 Dunham, I. etal. Plus 19345573-19345660

338418 Dunham, I. etal. Plus 19435506-19435596

338501 Dunham, I. et.al. Plus 21244713-21244828

338506 Dunham, I. et.al. Plus 21221871-21221953

338523 Dunham, I. et.al. Plus 21509763-21509864

338662 Dunham, I. et.al. Plus 24404720-24404899

338804 Dunham, I. etal. Plus 27236005-27236108

338836 Dunham, I. et.al. Plus 27792166-27792272

338879 Dunham, I. et.al. Plus 28410653-28410734

338937 Dunham, I. et.al. Plus 29160655-29160725

338993 Dunham, I. etal. Plus 30077787-30078184

339047 Dunham, I. et.al. Plus 30760793-30760968

339100 Dunham, I. et.al. Plus 31141680-31141765

339114 Dunham, I. etal. Plus 31456454-31456519

339121 Dunham, I. et.al. Plus 31583467-31583536

339170 Dunham, I. et.al. Plus 32216399-32216527

339293 Dunham, I. etal. Plus 33223671-33223819

332858 Dunham, I. et.al. Minus 1339607-1339397

332982 Dunham, I. et.al. Minus 2628296-2628109

332984 Dunham, I. et.al. Minus 2632606-2632457

332998 Dunham, I. et.al. Minus 2711704-2711565

333058 Dunham, I. et.al. Minus 3028925-3028811

333097 Dunham, I. et.al. Minus 3204124-3204036

333121 Dunham, I. etal. Minus 3308446-3308358

333122 Dunham, I. etal. Minus 3309596-3309531

333123 Dunham, I. et.al. Minus 3310817-3310749

333140 Dunham, I. et.al. Minus 3377220-3376309

333260 Dunham, I. et.al. Minus 4308400-4308304

333603 Dunham, I. etal. Minus 6466335-6465727

333604 Dunham, I. etal. Minus 6467090-6466768

333904 Dunham, I. et.al. Minus 8217374-8217261

333906 Dunham, I. et.al. Minus 8218238-8218063

334183 Dunham, I. etal. Minus 11832582-11832508

334187 Dunham, I. et.al. Minus 11921456-11921205

334222 Dunham, I. et.al. Minus 12732417-12732289

334223 Dunham, I. et.al. Minus 12734365-12734269

334255 Dunham, I. etal. Minus 13200776-13200692

334492 Dunham, I. et.al. Minus 14478333-14478172

334648 Dunham, I. et.al. Minus 15363301-15363222

334787 Dunham, I. etal. Minus 16299093-16298937

334933 Dunham, I. et.al. Minus 20078117-20077991 45 Dunham, et al Minus 20 38885-20138637

334967 Dunham, et al Minus 20173311-20173218

334990 Dunham, I et al Minus 20341159-20341087

335093 Dunham, et al Minus 21297367-21297214

335288 Dunham, et al Minus 22304275-22303770

335289 Dunham, l et al Minus 22305950-22305708

335548 Dunham, et al Minus 24662773-24662673

335551 Dunham, et al Minus 24679828-24678961

335619 Dunham, et al Minus 25082677-25082498

335620 Dunham, et al Minus 25092561-25092434

335621 Dunham, et al Minus 25098878-25098767

335682 Dunham, et al Minus 25421215-25421093

335755 Dunham, et al Minus 25763806-25763747

335814 Dunham, et al Minus 26320043-26319845

335815 Dunham, et al Minus 26320518-26320421

335835 Dunham, et al Minus 26393311-26393245

335851 Dunham, et al Minus 26604863-26604742

335868 Dunham, et al Minus 26711437-26711300

335896 Dunham, et al Minus 26977639-26977558

335936 Dunham, et al Minus 27360474-27360400

335948 Dunham, et al Minus 27555924-27555788

336066 Dunham, et al Minus 29241080-29240842

336205 Dunham, et al Minus 30477456-30477311

336275 Dunham, et al Minus 32086675-32086536

336292 Dunham, et al Minus 32818035-32817927

336331 Dunham, et al Minus 33594527-33594371

336419 Dunham, et al Minus 34052568-34052445

336675 Dunham, et al Minus 2020758-2020664

336684 Dunham, et al Minus 2158060-2157993

336716 Dunham, et al Minus 3259952-3259862

336798 Dunham, et al Minus 5888954-5888757

337043 Dunham, et al Minus 17407330-17407251

337046 Dunham, et al Minus 17610892-17610821

337128 Dunham, et al Minus 22215251-22215034

337192 Dunham, et al Minus 24591853-24591771

337194 Dunham, et al Minus 24610510-24610359

337229 Dunham, et al Minus 26716579-26716481

337325 Dunham, et al Minus 30015948-30015800

337497 Dunham, et al Minus 33371317-33371258

337500 Dunham, et al Minus 33376212-33376158

337603 Dunham, et al Minus 1299296-1299194

337605 Dunham, et al Minus 1346565-1346397

337671 Dunham, et al Minus 3260634-3260547

337786 Dunham, et al Minus 4133203 4133081

337862 Dunham, et al Minus 5347658-5347550

338083 Dunham, et al Minus 9318438-9318301

338158 Dunham, et al Minus 11794465-11794343

338161 Dunham, et al Minus 12124716-12124658

338182 Dunham, et al Minus 12824919-12824827

338189 Dunham, et al Minus 12878594-12878478

338199 Dunham, et al Minus 13760865-13760780

338215 Dunham, et al Minus 14055447-14055355

338469 Dunham, et al Minus 20520387-20520242

338549 Dunham, et al Minus 22049171-22049081

338561 Dunham, et al Minus 22311966-22311856

338671 Dunham, et al Minus 24508421-24508346

338676 Dunham, et al Minus 24637427-24637369

338726 Dunham, et al Minus 25926206-25925618

338779 Dunham, et al Minus 27030151-27029795

338871 Dunham, et al Minus 28301708-28301611

338872 Dunham, etal Minus 28300921-28300790

338966 Dunham, et al Minus 29614876-29614749

339229 Dunham, et al Minus 32722330-32722199

339264 Dunham, et al Minus 32975145-32975053

325228 6381940 Plus 2630-2694

325235 6381943 Minus 162154-162264

329588 3962484 Plus 1169-1619

329560 3962491 Plus 2095-2990

329541 3983503 Minus 2765-3059

325328 5866875 Plus 86780 8685'

325340 6017033 Minus 166656-166819

325373 5866920 Minus 1136686-1136777

325367 5866920 Minus 922881-922958

325389 5866921 Plus 239672-239759

325436 5866939 Minus 29778-2990^"

325498 5866967 Plus 173372-173930

325471 6017034 Minus 289268-289342

325557 6056302 Plus 50921-51050

325559 6249595 Minus 118590-119172

325560 6249595 Minus 133794-133981

325569 6249599 Plus 79927-80217

325587 6682462 Plus 126724-126967

325585 6682462 Plus 73476-73574

325597 5866992 Plus 1065020-1065089

325639 5867002 Plus 253525-253608 nus -

325740 5867038 Minus 207533-207690

325792 6469828 ^' Minus 1018-1176

325735 6552447 Minus 269122-269190

325685 6682468 Plus 117397-117483

325686 6682468 Plus 118337-118439

325819 6682490 Minus 130314-130370

329764 6048195 Minus 109733-109968

329703 6065793 Minus 139994-140138

329643 6448539 Plus 53403-53537

329816 6624888 Minus 70296-70423

329860 6687260 Minus 163474-163605

325883 5867087 Plus 22498-22663

325895 5867097 Plus 358317-358476

325925 5867124 Plus 115749-115962

325932 5867127 Plus 7369-7441

325941 5867133 Minus 64228-64402

325969 5867153 Plus 101911-102081

325971 5867153 Plus 105841-106035

329993 4567166 Minus 101307-101434

330020 6671887 Plus 172397-172491

326163 5867168 Minus 7831-8035

326274 5867171 Minus 410289-410404

326025 5867176 Plus 70854-70915

326046 5867182 Minus 62668-62825

326099 5867186 Minus 661381-661510

326108 5867187 Minus 23784-23903

326165 5867208 Minus 62787-62929

326189 5867212 Plus 69288-69413

326204 5867218 Minus 148088-148200

326230 5867230 Minus 301868-301972

330052 4567182 Plus 352560-352963

330036 6042048 Plus 117120-117216

326360 5867293 Plus 13627-13844

326589 5867320 Plus 22760-22919

326393 5867341 Plus 41702-41841

326505 5867435 Minus 8818-8949

326515 5867439 Plus 36683-36809

326592 6138928 Plus 23689-23828

330107 6015249 Minus 100091-100282

330106 6015249 Minus 99443-99778

330100 6015253 Plus 21166-21301

330093 6015278 Plus 1043-1199

330088 6015293 Plus 37517-37638

330085 6015302 Minus 59613-59770

330120 6671864 Minus 127553-127656

330123 6671869 Minus 35311-35406

326742 5867611 Minus 95187-95248

326605 5867637 Plus 24656-24749

326818 6117831 Minus 15199-15309

326720 6552456 Plus 84525-84677

326770 6598307 Minus 513603-513668

326692 6682502 Plus 117697-117899

326693 6682502 Minus 335002-335095

326983 5867657 Minus 16023-16581

326991 5867660 Plus 18147-18339

326936 6004446 Minus 10217-10357

326964 6469836 Plus 75340-75456

327040 6531965 Plus 783670-783817

327053 6531965 Plus 2247267-2247437

327075 6531965 Plus 4041318-4041431

327085 6531965 Plus 4734947-4735069

327036 6531965 Plus 319951-320040

327130 6531976 Plus 20247-22343

327156 5866841 Minus 2462-2620

327288 5867481 Plus 48583-48773

327332 5867516 Minus 56361-56532

327220 5867525 Minus 65701-65781

327224 5867534 Plus 188468-188544

327321 6249562 Minus 99745-99836

327361 6552412 Minus 61013-62130

327396 5867743 Plus 8702-8820

327414 5867750 Plus 102461-102586

327442 5867759 Plus 111483-111618

327467 5867772 Plus 88030-88151

327473 5867775 Plus 75101-75181

327483 5867783 Plus 181573-181662

327377 5867793 Minus 37610-37676

327562 5867804 Minus 343989-344474

327568 5867811 Minus 46152-46287

327606 6004463 Plus 200262-200495

327611 5867868 Minus 175063-175392

327642 5867891 Minus 2513-2743

327654 5867910 Minus 97564-97710

327734 5867940 Minus 31003-31583 327775 5867964 Minus 130791-130871

327796 5867982 Plus 85267-85405

327840 6249578 Minus 73065-73206

330208 6013599 Plus 66517-66931

330263 6671884 Minus 101503-101634

328004 5867993 Minus 157407-157887

328101 5868020 Plus 289920-290014

328100 5868020 Minus 263545-263635

328113 5868024 Minus 80378-80491

328157 5868064 Plus 73326-73615

328196 5868080 Minus 16551-16729

328197 5868081 Minus 42133-42438

327940 5868197 Minus 95240-95428

327984 5868216 Plus 66611-66677

328021 5902482 Plus 713478-714590

328068 6117819 Plus 253903-254022

328264 6381912 Plus 55086-55404

330300 2905862 Minus 3246-3302

328608 5868222 Minus 87770-87953

328600 5868229 Minus 38889-40010

328616 5868239 Plus 293920-294224

328623 5868246 Minus 120020-120126

328632 5868247 Plus 76734-76853

328666 5868254 Minus 778-901

328698 5868264 Minus 625555-625633

328700 5868264 Plus 764089-764203

328708 5868271 Minus 68114-68854

328735 5868289 Plus 89389-89455

328743 5868289 Plus 274638-274726

328806 5868324 Plus 29408-29684

328299 5868366 Minus 149708-149889

328342 5868383 Plus 59955-60094

328365 5868387 Minus 270724-270798

328369 5868388 Plus 75371-75583

328381 5868392 Plus 662758-662848

328451 5868425 Minus 217275-217336

328481 5868449 Minus 8987-9180

328500 5868464 Plus 59098-59481

328530 5868482 Plus 334973-335406

328664 6004473 Plus 1193739-1193866

328861 6381928 Minus 108317-108403

328908 5868493 Plus 117002-117059

328933 5868500 Plus 771755-771889

328934 5868500 Plus 846342-846448

328949 6456765 Minus 43552-43619

330313 6042030 Minus 33642-33775

329005 5868542 Plus 85470-85673

330366 2944106 Plus 151837-151914

330372 6580495 Minus 317461-317688

329033 5868561 Minus 5390-5479

329037 6868562 Minus 32466-32562

329067 5868591 Minus 146417-147652

329134 5868679 Plus 29959-30018

329157 5868687 Minus 145940-146155

329178 5868704 Plus 179177-179463

329192 5868716 Plus 166936-167020

329194 5868716 Minus 304450-304559

329204 5868720 Minus 3050-3190

329224 5868728 Plus 27422-27664

329228 5868728 Minus 50118-50287

329288 5868771 Plus 25554-26299

329337 5868806 Minus 467155467222

329011 6682532 Plus 48658-48741

TABLE 9A: Potential Therapeutic, Diagnostic and Prognostic targets for Therapy of Lung Cancer

Table 9A shows about 1312 genes up-regulated in lung tumors (including squamous cell carcinomas, adenocarcinomas, small cell carcinomas, granulomatous and carcinoid tumors) relative to normal body tissues. These genes were selected from about 59680 probesets on the Eos/Affymetrix Hu03 Genechip array.

Table 9B show the accession numbers for those Pkey's lacking UnigenelD's for table 9A. For each probeset we have listed the gene cluster number from which the oligonucleotides were designed. Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs. These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California). The Genbank accession numbers for sequences comprising each cluster are listed in the "Accession" column.

Table 9C show the genomic positioning for those Pkey's lacking Unigene ID's and accession numbers in table 9A. For each predicted exon, we have listed the genomic sequence source used for prediction. Nucleotide locations of each predicted exon are also listed.

Pkey: Unique Eos probeset identifier number

ExAccn: Exemp lar Accession number, Genbank accession number

UnigenelD: Unigene number

Unigene Title: Unigene gene title

R1: Average of lung tumors (including squamous cell carcinomas, adenocarcinomas, small cell i jarcinomas, gπ average of normal lung samples

R2: Average of non-malignant lung disease samples (including bronchitis, emphysema, fibrosis, atelectasis, as

Pkey ExAccn UnigenelD Unigene Title R1 R2

400195 NM_007057*:Homo sapiens ZW10 interactor 1.00 1.00

400205 NM_006265*:Homo sapiens RAD21 (S. pombe) 15.80 396.00

400220 Eos Control 2.28 2.84

400277 Eos Control 7.68 9.72

400285 Eos Control 1.00 1.00

400288 X06256 Hs.149609 integrin, alpha 5 (fibronectin receptor, 1.04 2.24

400289 X07820 Hs.2258 matrix metalloproteinase iO (stromelysin 132.45 4.00

400298 AA032279 Hs.61635 six transmembrane epithelial antigen of 43.86 74.00

400301 X03635 Hs.1657 estrogen receptor 1 1.00 1.00

400303 AA242758 Hs.79136 LIV-1 protein, estrogen regulated 1.75 1.65

400328 X87344 Hs.180062 transporter 2, ATP-binding cassette, sub 0.87 1.80

400419 AF084545 Target 156.55 253.00

400512 NM_030878*:Homo sapiens cytochrome P450, 1.00 2.00

400517 AF242388 lengsiπ 3.67 87.00

400560 NM_030878*:Homo sapiens cytochrome P450, 1.00 1.00

400664 NM_002425:Homo sapiens matrix metallopro 20.26 45.00

400665 NM_002425:Homo sapiens matrix metallopro 1.36 1.07

400666 NM_002425:Homo sapiens matrix metallopro 3.26 3.22

400749 NM_003105*:Homo sapiens sortilin-related 1.00 91.00

400763 Target Exon 7.63 24.00

401027 Target Exon 1.00 1.00

401093 C12000586*:gi|6330167|dbj|BAA86477.11 (A 1.00 155.00

401203 Target Exon 1.00 86.00

401212 C12000457*:gi|7512178|pir|IT30337 polypr 1.00 400.00

401411 ENSP00000247172*:HYPOTHETICAL 126.2 kDa 1.00 72.00

401435 C14000397*:gi|7499898|pir||T33295 hypoth 1.00 64.00

401464 AF039241 histone deacetylase 5 3.82 49.00

401714 ENSP00000241802*:CDNA FLJ11007 FIS, CLON 2.02 40.00

401747 Homo sapiens keratin 17 (KRT17) 128.43 68.00

401760 Target Exon 1.74 35.00

401780 NM_005557*:Homo sapiens keratin 16 (foca 26.47 10.50

401781 Target Exon 10.33 4.61

401785 NM_002275*:Homo sapiens keratin 15 (KRT1 4.13 2.70

401797 Target Exon 1.44 2.10

401961 NM_021626:Homo sapiens serine carboxypep 1.41 1.86

401985 AF053004 class I cytokine receptor 1.00 177.00

401994 Target Exon 61.84 47.00

402075 ENSP00000251056*:Plasma membrane calcium 1.00 1.00

402260 NM_001436*:Homo sapiens fibrillarin (FBL 1.58 1.39

402265 Target Exon 2.09 35.00

402297 Target Exon 1.00 92.00

402408 NM 030920*:Homo sapiens hypothetical pro 28.87 13.00

402420 C1000823*:gi|10432400|emb|CAC10290.1| (A 1.00 1.44

402674 Target Exon 7.44 243.00

402802 NM_001397:Homo sapiens endothelin conver 1.00 70.00

402994 NM_002463*:Homo sapiens myxovirus (influ 1.37 1.43

403137 NM_005381*:Homo sapiens nucleolin (NCL), 1.00 19.00

403306 NM.006825 transmembrane protein (63kD), endoplasmi 1.00 43.00

403329 Target Exon 1.00 61.00

403381 ENSP00000231844*:Ecotropic virus integra 1.00 119.00

403478 NM_022342:Homo sapiens kinesin protein 9 28.13 136.00

403485 C3001813*:gi|12737279|ref|XP_012163.1| k 20.23 76.00

403627 Target Exon 6.30 29.33

403715 Target Exon 1.30 35.00

404044 ENSP00000237855*:DJ398G3.2 (NOVEL PROTEI 1.00 54.00

404076 NM 016020*:Homo sapiens CGI-75 protein ( 14.29 91.00

404101 C8000950:gi|423560|pir||A47318 RNA-biπdi 1.00 1.00

404140 NM_006510:Homo sapiens ret finger protei 1.42 1.44

404165 ENSP00000244562:NRH dehydrogenase [quiπo 1.00 54.00

404185 Target Exon 1.00 117.00

404210 NM_005936:Homo sapiens myeloid/lymphoid 5.93 13.77

404253 NM_021058*:Homo sapiens H2B histone fami 1.00 1.00 404287 C6001909 gι|704441|db]|BAA189091| (D298 2971 4200 404298 C6001238* gι|121715|sp|P26697|GTA3_CHICK 1 30 1 00 404347 Target Exon 1 00 1 00 404440 NM_021048 Homo sapiens melanoma antigen, 1 00 1500 404721 NM_005596* Homo sapiens nuclear factor I 1 00 6000 404794 NMJJ00078 cholesteryl ester transfer protein, plas 1 07 1 38 404854 Target Exon 1 61 201 404877 NMJ05365 Homo sapiens melanoma antigen, 1 00 1 00 404927 Target Exon 1 00 1 00 404996 Target Exon 1 00 1 00 405449 CY000047*gι|11427234|ref|XP_009399 1| z 1 00 1 00 405568 NMJ31413* Homo sapiens cat eye syndrome 1 00 7800 405572 Target Exon 076 1 14 405646 C12000200 gι|4557225|reflNP_000005 1| al 1 01 1 28 405676 BE336714 cytochrome c-1 1 13 289 405770 NM 002362 Homo sapiens melanoma antigen, 4552 3700 405932 C15000305 gι|3806122|gb]AAC691981| (AF0 1 99 1 99 406137 NM_000179* Homo sapiens mutS (E coli) h 277 238 406360 Target Exon 1 00 3500 406399 NM_003122* Homo sapiens serine protease 1 00 3900 406467 Target Exon 1 00 1 00 406621 X57809 Hs 181125 immunoglobulin lambda locus 1 41 1 74 406642 AJ245210 gb Homo sapiens mRNA for immunoglobulin 216 391 406663 U24683 Hs 293441 immunoglobulin heavy constant mu 207 293 406671 AA129547 Hs 285754 met proto-oncogene (hepatocyte growth fa 1500 51 00 406673 M34996 Hs 198253 major histocompatibility complex, class 098 309 406676 X58399 Hs 81221 Human L2-9 transcript of unrearranged im 1 30 1 53 406678 U77534 gb Human clone 1A11 immunoglobulin vaπa 1 33 1 45 406685 M18728 gb Human nonspecific crossreactmg antig 1 46 285 406687 M31126 Hs 272822 pregnancy specific beta-1 -glycoprotem 9 861 850 406690 M29540 Hs 220529 carcinoembryonic antigen-related cell ad 22637 35000 406698 X03068 Hs 73931 major histocompatibility complex, class 1 01 252 406815 AA833930 Hs 288036 tRNA isopentenylpyrophosphate transferas 2025 3200 406851 AA609784 major histocompatibility complex, class 075 1 91 406964 M21305 gb Human alpha satellite and satellite 3 38 15 111400 406967 M24349 gb Human parathyroid hormone-like protei 1 00 1 00 406974 M57293 gb Human parathyroid hormone-related pep 1 00 1 00 407103 AA424881 Hs 256301 hypothetical protein MGC13170 1 7 1 10 407128 R83312 Hs 237260 EST 1 00 1 00 407137 T97307 gb ye53h05 s1 Soares fetal liver spleen 14270 13500 407168 R45175 Hs 117183 ESTs 216 1800 407239 AA076350 Hs 67846 leukocyte immunoglobuliπ-like receptor, 1 10 1 57 407242 M18728 gb Human nonspecific crossreactmg antig 1 12 285 407244 M10014 Hs 75431 fibrinogen, gamma polypeptide 3 24 1538 407289 AA135159 Hs 203349 Homo sapiens cDNA FLJ12149 fis, clone MA 353 368 407300 AA102616 Hs 120769 gb zn43e07 s1 Stratagene HeLa cell s393 1974 7300 407366 AF026942 Hs 271530 gb Homo sapiens cιg33 mRNA, partial sequ 006 825 407378 AA299264 Hs 57776 ESTs, Moderately similar to I38022hypot 1 00 2600 407430 AF169351 gb Homo sapiens protein tyrosine phospha 1 00 2500 407453 AJ 132087 gb Homo sapiens mRNA for axonemal dynem 1 00 7500 407577 AW131324 Hs 246759 hypothetical protein MGC12538 1 00 1 00 407634 AW016569 Hs 136414 UDP-GlcNAc betaGal beta-1, 3-N-acetylgluc 111 20 22800 407710 AW022727 Hs 23616 ESTs 1 00 2800 407720 AB037776 Hs 38002 KIAA1355 protein 1 89 1 31 407746 AK001962 hypothetical protein FLJ 11100 1 00 1 00 407756 AA116021 Hs 38260 ubiquitm specific protease 18 451 500 407758 D50915 Hs 38365 KIAA0125 gene product 1 00 2800 407782 AA608956 Hs 112619 ESTs, Moderately similar to PURKINJE CEL 097 1 14 407788 BE514982 Hs 38991 S100 calcium-binding protein A2 788 383 407790 AI027274 Hs 288941 Homo sapiens cDNA FLJ14866 fis, clone PL 363 4200 407811 AW190902 Hs 40098 cysteine knot superfamily 1, BMP antagon 8996 10900 407839 AA045144 Hs 161566 ESTs 17391 10800 407944 R34008 Hs 239727 desmocollin 2 111 30 7000 408000 L11690 Hs 620 bullous pemphigoid antigen 1 (230/240kD) 151 17 800 408031 AA081395 Hs 42173 Homo sapiens cDNA FLJ 10366 fis, clone NT 991 9300 408063 BE086548 Hs 42346 calcineurin binding protein calsarcιn-1 19578 231 00 408070 AW148852 gb xf05d05 x1 NCI_CGAP_Brn35 Homo sapien 1 00 1 00 408101 AW968504 Hs 123073 CDC2-related protein kinase 7 3784 61 00 408122 AI432652 Hs 42824 hypothetical protein FU10718 085 1 71 408212 AA297567 Hs 43728 hypothetical protein 588 791 408243 Y00787 Hs 624 interleukin 8 427 998 408349 BE546947 Hs 44276 homeo box CIO 379 346 408353 BE439838 Hs 44298 mitochondπal ribosomal protein S17 1 88 1 65 408354 AI382803 Hs 159235 ESTs 1 00 7300 408369 R38438 Hs 182575 solute carrier family 15 (H??? transport 1 41 1650 408380 AF123050 Hs 44532 diubiquitm 1519 3722 408482 NM_000676 Hs 45743 adenosine A2b receptor 1 65 1 19 408522 AI541214 Hs 6320 Small prolme-πch protein SPRK [human, 1 98 1 24 408536 AW381532 Hs 135188 ESTs 1 55 1 50 408545 AW235405 Hs 253690 ESTs 1 00 1 00 408572 AA055611 Hs 226568 ESTs, Moderately similar to ALU4_HUMAN A 1 00 4400 408633 AW963372 Hs 46677 PRO2000 protein 107 16 5600 408660 AA525775 ESTs, Moderately similar to PC4259 fern 1 00 1 00 408761 AA057264 Hs 238936 ESTs, Weakly similar to (deflme not ava 5224 141 00 408771 AW732573 Hs 47584 potassium voltage-gated channel, delayed 305 10900 408783 AF192522 Hs.47701 NPC1 (Niemann-Pick disease, type C1, gen 1.02 1.07

408790 AW580227 Hs.47860 πeurotrophic tyrosine kinase, receptor, 41.19 61.00

408805 H69912 Hs.48269 vaccinia related kinase 1 24.67 45.00

408841 AW438865 Hs.256862 ESTs 1.00 58.00

408873 AL046017 Hs.182278 calmodulin 2 (phosphorylase kinase, delt 1.00 89.00

408908 BE296227 Hs.250822 serine/threonine kinase 15 7.76 1.00

408992 AA059325 Hs.71642 guanine nucleotide binding protein (G pr 1.00 1.00

408996 AI979168 Hs.344096 glycoprotein (transmembrane) nmb 3.71 5.50

409015 BE389387 Hs.49767 NM_004553:Homo sapiens NADH dehydrogenas 1.44 1.24

409038 T97490 Hs.50002 small inducible cytokine subfamily A (Cy 4.28 5.32

409041 AB033025 Hs.50081 Hypothetical protein, XP_051860 (KIAA119 112.42 195.00

409077 AA401369 Hs.190721 ESTs 1.00 17.00

409093 BE243834 Hs.50441 CGI-04 protein 2.02 1.93

409103 AF251237 Hs.112208 XAGE-1 protein 80.44 40.00

409142 AL136877 Hs.50758 SMC4 (structural maintenance of chromoso 14.87 6.00

409187 AF154830 Hs.50966 carbarπoyl-phosphate synthetase 1, mitoch 1.00 1.00

409228 AI654298 Hs.271695 ESTs, Weakly similar to 2109260A B cell 1.22 1.00

409234 AI879419 Hs.27206 ESTs 1.00 1.00

409268 AA625304 Hs.187579 ESTs 11.90 23.00

409269 AA576953 Hs.22972 hypothetical protein FLJ13352 1.00 1.00

409361 NM_005982 Hs.54416 sine oculis homeobox (Drosophila) homolo 168.91 35.00

409404 BE220053 Hs.129056 ESTs 1.00 1.00

409420 Z15008 Hs.54451 laminin, gamma 2 (nicein (100kD), kalini 79.74 96.00

409430 R21945 Hs.346735 splicing factor, arginiπe/serine-rich 5 1.45 2.10

409446 AI561173 Hs.67688 ESTs 1.00 4.00

409506 NM J06153 Hs.54589 NCK adaptor protein 1 3.97 28.00

409522 AA075382 gb:zm87b03.s1 Stratagene ovarian cancer 15.98 141.00

409582 AA401369 Hs.190721 ESTs 1.00 17.00

409632 W74001 Hs.55279 serine (or cysteine) proteinase inhibito 292.12 79.00

409705 M37762 Hs.56023 brain-derived πeurotrophic factor 1.00 82.00

409719 AI769160 Hs.108681 Homo sapiens brain tumor associated prat 1.00 1.00

409731 AA125985 Hs.56145 thymosin, beta, identified in neuroblast 0.12 18.12

409744 AW675258 Hs.56265 Homo sapiens mRNA; cDNA DKFZp586P2321 (f 20.75 51.00

409757 NM.001898 Hs.123114 cystatin SN 22.46 15.80

409866 AW502152 gb:UI-HF-BR0p-ajr-f-11-0-Ul.r1 NIH_MGC_5 1.00 1.00

409893 AW247090 Hs.57101 minichromosome maintenance deficient (S. 1.50 1.09

409902 AI337658 Hs.156351 ESTs 25.92 50.00

409935 AW511413 Hs.278025 ESTs 2.63 2.11

409956 AW103364 Hs.727 inhibin, beta A (activiπ A, activin AB a 2.17 4.01

409958 NMJ01523 Hs.57697 hyaluronan synthase 1 0.91 2.07

410001 AB041036 Hs.57771 kallikrein H 1.04 2.28

410032 BE065985 gb: C3-BT0319-120200-014-a09 BT0319 Homo 1.00 58.00

410037 AB020725 Hs.58009 KIAA0918 protein 1.00 34.00

410044 BE566742 Hs.58169 highly expressed in cancer, rich in leuc 1.00 1.00

410048 W76467 Hs.58218 proline oxidase homolog 1.03 1.44

410076 T05387 Hs.7991 ESTs 1.12 1.50

410102 AW248508 Hs.279727 Homo sapiens cDNA FLJ14035 fis, clone HE 9.89 1.00

410153 BE311926 Hs.15830 hypothetical protein FLJ12691 1.00 1.00

410166 AK001376 Hs.59346 hypothetical protein FLJ 10514 1.00 1.00

410193 AJ132592 Hs.59757 zinc finger protein 281 42.01 51.00

410274 AA381807 Hs.61762 hypoxia-inducible protein 2 1.72 1.32

410309 BE043077 Hs.278153 ESTs 1.00 2.00

410340 AW182833 Hs.112188 hypothetical protein FLJ13149 32.08 75.00

410348 AW182663 Hs.95469 ESTs 1.00 1.00

410407 X66839 Hs.63287 carbonic anhydrase IX 1.40 1.11

410418 D31382 Hs.63325 transmembrane protease, serine 4 4.30 2.03

410438 AB037756 Hs.45207 hypothetical protein KIAA1335 1.00 18.00

410553 AW016824 Hs.255527 hypothetical protein MGC14128 1.34 1.04

410555 W27235 Hs.64311 a disintegrin and metalloproteinase doma 23.99 1.41

410561 BE540255 Hs.6994 Homo sapiens cDNA: FLJ22044 fis, clone H 10.04 1.00

410681 AW246890 Hs.65425 calbindin 1, (28kD) 10.88 18.92

410781 AI375672 Hs.165028 ESTs 1.00 57.00

411027 AF072099 Hs.67846 leukocyte im unoglobulin-like receptor, 1.62 3.78

411074 X60435 Hs.68137 adenylate cyclase activating polypeptide 1.00 1.15

411089 AA456454 cell division cycle 2-like 1 (PITSLRE pr 1.56 1.58

411152 BE069199 gb:QV3-BT0379-010300-105-g03 BT0379 Homo 1.00 84.00

411248 AA551538 Hs.334605 Homo sapiens cDNA FLJ14408 fis, clone HE 1.82 1.45

411252 AB018549 Hs.69328 MD-2 protein 7.32 12.74

411263 BE297802 Hs.69360 kinesin-like 6 (mitotic centromere-assoc 3.44 2.55

411365 M76477 Hs.289082 GM2 ganglioside activator protein 1.35 2.02

411402 BE297855 Hs.69855 NRAS-related gene 1.00 46.00

411573 AB029000 Hs.70823 KIAA1077 protein 11.40 11.35

411579 AC005258 Hs.70830 U6 snRNA-associated Sm-like protein LSm7 1.08 1.90

411617 AA247994 Hs.90063 neurocalcin delta 1.74 2.57

411732 AA059325 Hs.71642 guanine nucleotide binding protein (G pr 1.02 1.00

411773 NM 006799 Hs.72026 protease, serine, 21 (testisin) 1.34 2.19

411789 AF245505 Hs.72157 Adlican 2.19 2.79

411800 N39342 Hs.103042 microtubute-associated protein 1B 23.34 34.00

411945 AL033527 Hs.92137 v-myc avian myelocy'omatosis viral oncog 1.00 8.00

412115 AK001763 Hs.73239 hypothetical protein FLJ10901 2.07 1.64

412140 AA219691 Hs.73625 RAB6 interacting, kinesin-like (rabkiπes 118.48 92.00

412276 BE262621 Hs.73798 macrophage migration inhibitory factor ( 1.98 1.49

412464 T78141 Hs.22826 ESTs, Weakly similar to 155214 salivary 1.16 1.34

412530 AA766268 Hs.266273 hypothetical protein FLJ 13346 41.52 84.00

412537 AL031778 nuclear transcription factor Y, alpha 17.90 55.00 412659 AW753865 Hs.74376 olfactomedin related ER localized protei 14.65 47.00

412719 AW016610 Hs.816 ESTs 382.46 128.00

412723 AA648459 Hs.335951 hypothetical protein AF301222 54.90 1.00

412811 H06382 ESTs 1.00 11.00

412817 AL037159 Hs.74619 proteasome (prosome, macropain) 26S subu 1.63 1.42

412863 AA121673 Hs.59757 zinc finger protein 281 17.63 56.00

412924 BE018422 Hs.75258 H2A histone family, member Y 1.00 22.00

413004 T35901 Hs.75117 interleukin enhancer binding factor 2, 4 2.19 2.05

413011 AW068115 Hs.821 biglycan 1.22 1.88

413048 M93221 Hs.75182 mannose receptor, C type 1 0.30 6.23

413063 AL035737 Hs.75184 chitiπase 3-like 1 (cartilage glycoprote 3.43 8.71

413129 AF292100 Hs.104613 RP42 homolog 4.67 4.77

413142 M81740 Hs.75212 ornithine decarboxylase 1 1.92 2.59

413223 AI732182 Hs.191866 ESTs 5.73 27.00

413248 T64858 Hs.21433 hypothetical protein DKFZp547J036 0.99 1.06

413273 U75679 Hs.75257 stem-loop (histone) binding protein 1.00 18.00

413278 BE563085 Hs.833 interferon-stimulated protein, 15 kDa 1.10 1.09

413281 AA861271 Hs.222024 transcription factor BMAL2 95.94 69.00

413364 BE536218 Hs.137516 fidgetin-like 1 1.00 1.00

413385 M34455 Hs.840 indoleamine-pyrrote 2,3 dioxygenase 0.95 2.09

413409 AI638418 Hs.1440 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 1.00 1.00

413453 AA129640 Hs.128065 ESTs 1.00 31.00

413527 BE250788 Hs.179882 hypothetical protein FLJ12443 1.08 1.46

413554 AA319146 Hs.75426 secretogranin II (chromogranin C) 79.15 114.00

413573 AI733859 Hs.149089 ESTs 1.00 1.00

413582 AW295647 Hs.71331 hypothetical protein MGC5350 8.80 10.00

413597 AW302885 Hs.117183 ESTs 1.00 1.00

413690 BE157489 gb:RC1-HT0375-120200-011-e06 HT0375 Homo 1.00 1.00

413691 AB023173 Hs.75478 ATPase, Class VI, type 11B 3.16 2.32

413719 BE439580 Hs.75498 small inducible cyto ine subfamily A (Cy 2.88 9.52

413753 U17760 Hs.75517 laminin, beta 3 (nicein (125kD), kalinin 144.10 108.00

413801 M62246 Hs.35406 ESTs, Highly similar to unnamed protein 1.00 17.00

413833 Z15005 Hs.75573 centromere protein E (312kD) 1.00 1.00

413882 AA132973 Hs.184492 ESTs 64.24 148.00

413926 AA133338 Hs.54310 ESTs 1.00 67.00

413943 AW294416 Hs.144687 Homo sapiens cDNA FLJ12981 fis, clone NT 43.42 42.00

413995 BE048146 Hs.75671 syntaxin 1A (brain) 1.23 1.11

414035 Y00630 Hs.75716 serine (or cysteine) proteinase inhibito 2.02 2.51

414142 AW368397 Hs.334485 Homo sapiens cDNA FLJ14438 fis, clone HE 1.00 102.00

414180 AI863304 Hs.120905 Homo sapiens cDNA FLJ 11448 fis, clone HE 6.92 77.00

414245 BE148072 Hs.75850 WAS protein family, member 1 1.00- 1.00

414275 AW970254 Hs.889 Charat-Leyden crystal protein 1.00 59.00

414317 BE263280 Hs.75888 phosphogluconate dehydrogenase 1.52 1.73

414334 AA824298 Hs.21331 hypothetical protein FLJ10036 1.78 1.72

414341 D80004 Hs.75909 KIAA0182 protein 33.90 151.00

414368 W70171 Hs.75939 uridine onophosphate kinase 171.60 97.00

414416 AW409985 Hs.76084 hypothetical protein MGC2721 2.32 1.85

414430 AI346201 Hs.76118 ubiquitin carboxyl-terminal esterase L1 226.15 66.00

414570 Y00285 Hs.76473 insulin-like growth factor 2 receptor 1.64 1.98

414618 AI204600 Hs.96978 hypothetical protein MGC10764 1.87 72.00

414675 R79015 Hs.296281 interleukin enhancer binding factor 1 1.51 1.39

414683 S78296 Hs.76888 hypothetical protein MGC12702 43.61 64.00

414696 AF002020 Hs.76918 Niemaππ-Pick disease, type C1 28.63 71.00

414711 AI310440 Hs.288735 Homo sapiens cDNA FLJ13522 fis, clone PL 14.86 42.00

414718 H95348 Hs.107987 ESTs 1.00 5.00

414732 AW410976 Hs.77152 minichromosome maintenance deficient (S. 1.64 1.44

414747 U30872 Hs.77204 centromere protein F (350/400kD, mitosin 65.01 74.00

414761 AU077228 Hs.77256 enhancer of zeste (Drosophila) homolog 2 130.35 121.00

414774 X02419 Hs.77274 plasminogen activator, urokinase 2.24 2.19

414806 D14694 Hs.77329 phosphatidylserine synthase 1 1.63 1.53

414809 AI434699 Hs.77356 transferrin receptor (p90, CD71) 1.97 2.60

414812 X72755 Hs.77367 monokinβ induced by gamma interferon 3.48 10.60

414825 X06370 Hs.77432 epidermal growth factor receptor (avian 103.22 143.00

414839 X63692 Hs.77462 DNA (cytosine-5-)-methyltransferase 1 1.80 1.69

414883 AA926960 CDC28 protein kinase 1 14.29 10.06

414907 X90725 Hs.77597 polo (Drosophia)-like kinase 1.95 2.20

414914 U49844 Hs.77613 ataxia telangiectasia and Rad3 related 3.00 2.90

414945 BE076358 Hs.77667 lymphocyte antigen 6 complex, locus E 1.02 1.21

414972 BE263782 Hs.77695 KIAA0008 gene product 1.00 1.00

415014 AW954064 Hs.24951 ESTs 1.42 2.84

415091 AL044872 Hs.77910 3-hydroxy-3-methylglutaryl-Coenzyme A sy 1.00 30.00

415138 C18356 Hs.295944 tissue factor pathway inhibitor 2 34.72 107.00

415227 AW621113 Hs.72402 ESTs 1.87 49.00

415238 R37780 Hs.21422 ESTs 1.00 1.00

415263 AA948033 Hs.130853 ESTs 1.00 1.00

415295 R41450 Hs.6546 ESTs 1.00 1.00

415339 NM_015156 Hs.78398 KIAA0071 protein 51.18 166.00

415669 NM_005025 Hs.78589 serine (or cysteine) proteinase inhibito 30.84 63.00

415674 BE394784 Hs.78596 proteasome (prosome, macropain) subunit, 1.48 1.39

415709 AA649850 Hs.278558 ESTs 1.00 1.00

415735 AA704162 Hs.120811 ESTs, Weakly similar to I38022 hypotheti 1.00 72.00

415799 AA653718 Hs.225841 DKFZP434D193 protein 6.23 31.00

415817 U88967 Hs.78867 protein tyrosine phosphatase, receptor-t 24.30 1.00

415857 AA866115 Hs.127797 Homo sapiens cDNA FLJ 11381 fis, clone HE 32.51 35.00

415989 AI267700 ESTs 78.89 1.00 416018 AW138239 Hs.78977 proproteiπ convertase subtilisin/kexin t 1.00 1.00

416065 BE267931 Hs.78996 proliferating cell nuclear antigen 3.35 2.32

416111 AA033813 Hs.79018 chromatin assembly factor 1 , subunit A ( 39.03 3.00

416177 AA174069 Hs.187607 ESTs 1.00 9.00

416178 AI808527 Hs.192822 serologlcally defined breast cancer anti 3.83 3.76

416208 AW291168 Hs.41295 ESTs, Weakly similar to MUC2_HUMAN MUCIN 3.67 1.00

416209 AA236776 Hs.79078 MAD2 (mitotic arrest deficient, yeast, h 9.70 1.00

416239 AL038450 Hs.48948 ESTs 83.87 129.00

416250 AA581386 Hs.73452 hypothetical protein MGC10791 1.96 2.12

416322 BE019494 Hs.79217 pyrroline-5-carboxylate reductase 1 2.08 1.73

416423 H54375 Hs.268921 ESTs 1.00 89.00

416448 L13210 Hs.79339 lectin, galactoside-binding, soluble, 3 1.28 1.54

416498 U33632 Hs.79351 potassium channel, subfamily K, member 1 27.29 67.00

416658 U03272 Hs.79432 fibrillin 2 (congenital contractural ara 53.29 51.00

416661 AA634543 Hs.79440 IGF-II mRNA-binding protein 3 9.96 5.00

416722 AA354604 Hs.122546 ^• hypothetical protein FLJ23017 3.68 33.00

416819 U77735 Hs.80205 pim-2 oncogene 1.59 1.84

416936 N21352 Hs.42987 ESTs, Weakly similar to S21348 probable 1.00 1.00

417034 NMJW6183 Hs.80962 neurotensin 1.00 1.00

417061 AI675944 Hs.188691 Homo sapiens cDNA FLJ12033 fis, clone HE 32.95 156.00

417079 U65590 Hs.81134 interleukin 1 receptor antagonist 3.91 4.93

417218 AA129547 Hs.285754 met proto-oncogene (hepatocyte growth fa 1.00 51.00

417233 W25005 Hs.24395 small inducible cytokine subfamily B (Cy 3.38 2.05

417308 H60720 Hs.81892 KIAA0101 gene product 82.94 25.36

417315 AI080042 Hs.180450 ribosomal protein S24 106.61 121.00

417324 AW265494 ESTs 1.20 1.28

417366 BE185289 Hs.1076 small proline-rich protein 1B (cornifiπ) 8.97 3.27

417389 BE260964 Hs.82045 midkine (neurite growth-promoting factor 2.59 1.82

417428 N87579 Hs.278871 gb:LL2030F Human fetal heart, Lambda ZAP 1.00 52.00

417433 BE270266 Hs.82128 5T4 oncofetal trophoblast glycoprotein 304.75 173.00

417466 AI681547 Hs.59457 hypothetical protein FLJ22127 1.24 1.34

417512 AI979168 Hs.344096 glycoprotein (transmembrane) nmb 2.14 5.50

417515 L24203 Hs.82237 ataxia-telangiectasia group D-associated 2.66 1.68

417542 J04129 Hs.82269 progestagen-associated endometrial prole 1.28 1.35

417576 AA339449 Hs.82285 phosphoribosylglycinamide formyltransfer 42.76 51.00

417715 AW969587 Hs.86366 ESTs 6.35 2.75

417720 AA205625 Hs.208067 ESTs 113.31 56,00

417791 AW965339 Hs.111471 ESTs 39.98 16.00

417830 AW504786 Hs.122579 hypothetical protein FLJ10461 2.61 31.00

417866 AW067903 Hs.82772 collagen, type XI, alpha 1 2.35 2.44

417900 BE250127 Hs.82906 CDC20 (cell division cycle 20, S. cerevi 1.52 1.11

417933 X02308 Hs.82962 thymidylate synthetase 4.74 2.55

417944 AU077196 Hs.82985 collagen, type V, alpha 2 3.61 5.21

417975 AA641836 Hs.30085 hypothetical protein FLJ23186 12.49 38.00

417991 AA731452 Hs.190008 ESTs 1.00 26.00

418004 U37519 Hs.87539 aldehyde dehydrogenase 3 family, member 3.02 2.12

418007 M13509 Hs.83169 matrix metalloproteinase 1 (interstitial 187.59 1.00

418054 NM 002318 Hs.83354 lysyl oxidase-like 2 2.85 2.63

418057 NMJ12151 Hs.83363 coagulation factor VII l-associated (intr 1.54 1.69

418113 AI272141 Hs.83484 SRY (sex determining region Y)-box 4 6.82 5.22

418140 BE613836 . Hs.83551 microfibrillar-associated protein 2 1.26 1.46

418203 X54942 Hs.83758 CDC28 protein kinase 2 134.19 144.00

418207 C14685 Hs.34772 ESTs 1.00 1.00

418216 AA662240 Hs.283099 AF15q14 protein 64.66 61.00

418236 AW994005 Hs.337534 ESTs 18.53 147.00

418249 H89226 Hs.34892 KIAA1323 protein 30.53 106.00

418281 U09550 Hs.1154 oviductal glycoprotein 1, 120kD (mucin 9 1.00 3.00

418283 S79895 Hs.83942 cathepsin K (pycnodysostosis) 3.96 5,16

418300 AI433074 Hs.86682 Homo sapiens cDNA: FLJ21578 Bs, clone C 3.18 2.91

418322 AA284166 Hs.84113 cyclin-dependent kinase inhibitor 3 (CDK 11.96 6.68

418327 U70370 Hs.84136 paired-like homeodomain transcription fa 9.23 2.22

418345 AJ001696 Hs.241407 serine {or cysteine) proteinase inhibito 1.00 1.00

418379 AA218940 Hs.137516 fidgetin-like 1 21.68 44.00

418397 NMJ01269 Hs.84746 chromosome condensation 1 1.00 8.00

418403 D86978 Hs.84790 KIAA0225 protein 16.91 18.98

418462 BE001596 Hs.85266 integrin, beta 4 1.56 1.16

418478 U38945 Hs.1174 cyclin-dependent kinase Inhibitor 2A (me 3.22 2.38

418506 AA084248 Hs.85339 G protein-coupled receptor 39 2.66 2.22

418526 BE019020 Hs.85838 solute carrier family 16 (monocarboxylic 2.04 2.21

418538 BE244323 Hs.85951 exportin, tRNA (nuclear export receptor 1.33 37.00

418543 NMJ05329 Hs.85962 hyaluronan synthase 3 1.04 1.23

418574 N28754 M-phase phosphoprotein 9 48.60 85.00

418592 X99226 Hs.284153 Fancoπi anemia, complementation group A 18.24 26.00

418641 BE243136 Hs.86947 a disintegrin and metalloproteinase doma 1.19 1.41

418661 NMJ01949 Hs.1189 E2F transcription factor 3 29.05 43.00

418663 AK001100 Hs.41690 desmocollin 3 112.17 19.00

418678 NM 01327 Hs.87225 cancer/testis antigen 1.18 1.10

418686 Z36830 Hs.87268 annexiπ A8 1.54 1.98

418689 A1360883 Hs.274448 hypothetical protein FLJ11029 1.19 1.04

418712 Z42183 gb:HSC0BF041 normalized infant brain cDN 1.00 12.00

418727 AA227609 Hs.94834 ESTs 1.00 49.00

418738 AW388633 Hs.6682 solute carrier family 7, (cationic amino 49.85 1.00

418819 AA228776 Hs.191721 ESTs 1.00 140.00

418830 BE513731 Hs.88959 hypothetical protein MGC4816 20.97 23.00

418882 NMJ04996 Hs.89433 ATP-binding cassette, sub-family C (CFTR 57.09 35.00 418971 AA360392 Hs.87113 ESTs 1.00 12.00

418973 AA233056 Hs.191518 ESTs 4.89 28.00

419078 M93119 Hs.89584 insulinoma-associated 1 ' 1.00 10.00

419079 AW014836 Hs.18844 ESTs 1.09 1.98

419080 AW150835 Hs.18878 hypothetical protein FLJ21620 2.06 1.68

419088 AI538323' Hs.52620 integrin, beta 8 15.60 51.00

419092 J05581 Hs.89603 mucin l, transmembrane 1.11 1.83

419121 AA374372 Hs.89626 parathyroid hormone-like hormone 1.00 1.00

419171 NM 002846 Hs.89655 protein tyrosine phosphatase, receptor t 1.10 1.14

419183 U60669 Hs.89663 cytochrome P450, subfamily XXIV (vitamin 1.00 1.00

419216 AU076718 Hs.164021 small inducible cytokine subfamily B (Cy 3.18 2.43

419288 AA256106 Hs.87507 ESTs 1.00 34.00

419335 AW960146 Hs.284137 hypothetical protein FLJ 12888 1.00 8.00

419354 M62839 Hs.1252 apolipoprotein H (beta-2-glycoprotein I) 22.63 54.00

419359 AL043202 Hs.90073 chromosome segregation 1 (yeast homolog) 2.50 1.98

419423 D26488 Hs.90315 KIAA0007 protein 1.00 7.00

419443 D62703 gb:HUM316G10B Clontech human aorta polyA 1.00 12.00

419452 U33635 Hs.90572 PTK7 protein tyrosine kinase 7 1.64 1.84

419474 AW968619 Hs.155849 ESTs 13.63 62.00

419485 AA489023 Hs.99807 ESTs, Weakly similar to unnamed protein 4.27 2.26

419488 AA316241 Hs.90691 nucleophosmin/nucleoplasmin 3 3.66 3.63

419502 AU076704 fibrinogen, A alpha polypeptide 13.05 115.00

419539 AF070590 Hs.90869 Homo sapiens clones 24622 and 24623 mRNA 74.60 117.00

419556 U29615 Hs.91093 chitinase 1 (chitotriosidase) 1.47 4.98

419569 AI971651 Hs.91143 jagged 1 (Alagille syndrome) 1.00 4.00

419594 AA013051 Hs.91417 topoisomerase (DNA) II binding protein 94.30 94.00

419703 AI793257 Hs.128151 ESTs 15.26 50.00

419721 NM 001650 Hs.288650 aquaporin 4 1.00 191.00

419729 AA586442 Hs.21411 gb:πo53a03.s1 NCI_CGAP_SS1 Homo sapiens 1.00 59.00

419741 NMJ07019 Hs.93002 ubiquitin carrier protein E2-C 2.02 1.08

419745 AF042001 Hs.93005 slug (chicken homolog), zinc finger prat 1.00 1.00

419752 AA249573 Hs.152618 ESTs, Moderately similar to ZN91_HUMAN Z 29.87 77.00

419839 U24577 Hs.93304 phosphollpase A2, group VII (platelet-ac 50.99 214.00

419936 AI792788 gb:ol91d05.y5 NCI CGAP_Kid5 Homo sapiens 1.00 1.00

419937 AB040959 Hs.93836 DKFZP434N014 protein 1.64 2.47

419983 W55956 Hs.94030 Homo sapiens mRNA; cDNA DKFZp586E1624 (f 15.72 94.00

420005 AW271106 Hs.133294 ESTs 3.15 1.43

420047 AI478658 Hs.94631 brefeldin A-inhibited guanine nucleotide 12.45 39.00

420058 AK001423 Hs.94694 Homo sapiens cDNA FLJ10561 fis, clone NT 1.00 117.00

420162 BE378432 Hs.95577 cyclin-dependent kinase 4 1.43 1.21

420251 AW374968 Hs.348112 Human DNA sequence from clone RP5-1103G7 2.35 3.23

420259 AF004864 Hs.96253 calcium channel, voltage-dependent, P/Q 0.77 1.15

420281 AI623693 Hs.323494 ESTs 45.04 54.00

420309 AW043637 Hs.21766 ESTs, Weakly similar to ALU5_HUMAN ALU S 49.22 31.00

420332 NM_001756 Hs.1305 serine (or cysteine) proteinase inhibito 0.05 2.82

420380 AA640891 Hs.102406 ESTs 0.99 2.74

420462 AF050147 Hs.97932 chondramodulin I precursor 1.00 1.00

420520 AK001978 Hs.98510 similar to rabl 1-biπding protein 49.74 133.00

420552 AK000492 Hs.98806 hypothetical protein 94.65 88.00

420560 AW207748 Hs.59115 ESTs 1.00 17.00

420610 AI683183 Hs.99348 distal-less homeo box 5 1.00 13.00

420689 H79979 Hs.88678 ESTs 50.09 95.00

420721 AA927802 Hs.159471 ZAP3 protein 1.00 31.00

420759 T11832 Hs.127797 Homo sapiens cDNA FLJ11381 fis, clone HE 1.00 48.00

420783 AI659838 Hs.99923 lectin, galactoside-binding, soluble, 7 3.04 1.25

420900 AL045633 Hs.44269 ESTs 2.24 7.00

420931 AF044197 Hs.100431 small inducible cytokine B subfamily (Cy 1.00 8.00

421002 AF116030 Hs.100932 transcription factor 17 1.00 27.00

421027 AA761198 Hs.55254 ESTs 2.87 38.00

421037 AI684808 Hs.197653 ESTs 1.00 46.00

421041 N36914 Hs.14691 ESTs, Moderately similar to I38022 hypot 1.00 98.00

421073 NM 004689 Hs.101448 metastasis associated 1 1.34 1.46

421110 AJ250717 Hs.1355 cathepsin E 119.47 427.00

421133 AA401369 Hs.190721 ESTs 1.10 17.00

421150 AI913562 Hs.189902 ESTs 1.45 1.63

421155 H87879 Hs.102267 lysyl oxidase 1.00 15.00

421307 BE539976 Hs.103305 Homo sapiens mRNA; cDNA DKFZp434B0425 (f 1.37 1.10

421316 AA287203 Hs.324728 SMA5 1.00 21.00

421379 Y15221 Hs.103982 small inducible cytokine subfamily B (Cy 1.92 3.94

421451 AA291377 Hs.50831 ESTs 5.89 14.00

421474 U76362 Hs.104637 solute carrier family 1 (glutamate trans 1.46 1.76

421506 BE302796 Hs.105097 thymidine kinase 1, soluble 1.56 1.08

421508 NM 04833 Hs.105115 absent in melanoma 2 5.11 5.23

421515 Y11339 Hs.105352 GalNAc alpha-2, 6-sialyltransferase I, I 1.00 3.00

421524 AA312082 Hs.105445 GDNF family receptor alpha 1 2.63 10.58

421526 AL080121 Hs.105460 DKFZP564O0823 protein 1.46 1.88

421552 AF026692 Hs.105700 secreted frizzled-related protein 4 30.21 50.32

421574 AJ000152 Hs.105924 defensin, beta 2 1.67 1.74

421582 AI910275 trefoil factor 1 (breast cancer, estroge 1.23 1.00

421633 AF121860 Hs.106260 sorting nexin 10 1.00 116.00

421659 NM 014459 Hs.106511 protocadherin 17 0.05 6.33

421677 H64092 Hs.38282 ESTs 1.31 1.42

421753 BE314828 Hs.107911 ATP-binding cassette, sub-family B (MDR/ 1.41 1.20

421773 W69233 Hs.112457 ESTs 1.12 1.14

421777 BE562088 Hs.108196 HSPC037 protein 1.97 1.29 421800 AA298151 Hs 222969 ESTs 1 03 1 30

421817 AF146074 Hs 108660 ATP binding cassette, sub-family C (CFTR 1 88 1 59

421896 N62293 Hs 45107 ESTs 11 84 2280

421928 AF013758 Hs 109643 polyadeπylate binding protein-interactin 4589 9000

421931 NM 000814 Hs 1440 gamma aminobutyπc acid (GABA) A recepto 1 13 1 49

421948 L42583 Hs 334309 keratin 6A 51 83 2025

421975 AW961017 Hs 6459 hypothetical protein FLJ11856 1 17 1 15

422026 U80736 Hs 110826 trmucleotide repeat containing 9 1 00 5200

422094 AF129535 Hs 272027 F box only protein 5 6761 6200

422095 AI868872 Hs 282804 hypothetical protein FLJ22704 437 234

422109 S73265 Hs 1473 gastrin-releas g peptide 418 9550

422128 AW881145 gb QV0 OT0033-010400-182-a07 OT0033 Homo 4089 71 00

422129 AU076635 Hs 1478 serine (orcysteme) proteinase inhibito 1 13 1 38

422134 AW179019 Hs 112110 mitochondnal πbosomal protein L42 41 59 9600

422158 L10343 Hs 112341 protease inhibitor 3, skm-deπved (SKAL 237 1 10

422168 AA586894 Hs 112408 S100 calcium-binding protein A7 (psonas 329 1 68

422278 AF072873 Hs 114218 frizzled (Drosophila) homolog 6 493 573

422282 AF019225 Hs 114309 apolipoprotem L 1 49 1 71

422283 AW411307 Hs 114311 CDC45 (cell division cycle 45, S cerevis 2599 1091

422310 AA316622 Hs 98370 cytochrome P450, subfamily IIS, polypept 1 54 1 41

422311 AF073515 Hs 114948 cytokine receptor like factor 1 1 15 1 78

422330 D30783 Hs 115263 epiregulin 1 00 11200

422364 AF067800 Hs 115515 C-type (calcium dependent, carbohydrate- 939 6000

422406 AF025441 Hs 116206 Opa interacting protein 5 1833 5300

422424 AI186431 Hs 296638 prostate differentiation factor 1 71 321

422440 NM 04812 Hs 116724 aldo-keto reductase family 1, member B10 47 53 3200

422487 AJ010901 Hs 198267 mucin 4, tracheobronchial 7368 3554

422511 AU076442 Hs 117938 collagen, type XVII, alpha 1 17397 2600

422515 AW500470 Hs 117950 multifunctional polypeptide similar to S 468 292

422656 AI870435 Hs 1569 LIM homeobox protein 2 1 00 1 00

422737 M26939 Hs 119571 collagen, type III, alpha 1 (Ehlers-Danl 389 455

422756 AA441787 Hs 119689 glycoprote hormones, alpha polypeptide 1 05 1 46

422765 AW409701 Hs 1578 baculoviral IAP repeat-containing 5 (sur 388 1 53

422809 AK001379 Hs 121028 hypothetical protein FLJ10549 9956 5300

422867 L32137 Hs 1584 cartilage oligomeπc matπx protein (pse 1 69 3 17

422938 NM 001809 Hs 1594 centromere protein A (17kD) 7046 61 00

422956 BE545072 Hs 122579 ECT2 protein (Epithelial cell transformi 7774 3 00

422960 AW890487 Hs 63984 cadhenn 13, H-cadheπn (heart) 588 855

422963 AA401369 Hs 190721 ESTs 171 41 1700

422976 AU076657 Hs 1600 chaperonin containing TCP1, subunit 5 (e 212 1 62

422981 AF026445 Hs 122752 TATA box binding protein (TBP)-assocιate 1049 3500

422986 AA319777 Hs 221974 ESTs 1240 3247

423034 AL119930 gb DKFZp761A092_r1 761 (synonym hamy2) 1641 6000

423049 X59373 Hs 188023 ESTs, Moderately similar to HXDAJHUMAN H 1 00 1 00

423081 AF262992 Hs 123159 sperm associated antigen 4 1 82 296

423184 NMJ04428 Hs 1624 ephπn A1 1 14 1 53

423217 NM 000094 Hs 1640 collagen, type VII, alpha 1 (epider olys 2 14 1 69

423248 AA380177 Hs 125845 πbulose 5-phosphate-3-epιmerase 7 18 1400

423309 BE006775 Hs 126782 sushi-repeat protein 21 90 6400

423361 AW170055 Hs 47628 ESTs 1 00 1 00

423453 AW450737 Hs 128791 CGI-09 protein 5552 6600

423511 AF036329 Hs 129715 gonadotropin-releasmg hormone 2 088 1 17

423516 AB007933 Hs 129729 ligand of neuronal nitric oxide synthase 1 76 540

423551 AA327598 Hs 233785 ESTs 3 54 433

423554 M90516 Hs 1674 glutamine fructose-6 phosphate transamm 1 00 5000

423575 C18863 Hs 163443 Homo sapiens cDNA FLJ11576 fis, clone HE 3888 7000

423624 AI807408 Hs 166368 ESTs 1 00 6700

423634 AW959908 Hs 1690 hepaπn-binding growth factor binding pr 7602 1 00

423642 AW452650 Hs 157148 hypothetical protein MGC13204 19 14 5800

423662 AA642452 Hs 130881 B-cell CLUIymphoma 11A (zinc finger pro 361 1357

423673 BE003054 Hs 1695 matrix metalloproteinase 12 (macrophage 24073 4000

423698 AA329796 Hs 1098 DKFZp434J1813 protein 1 00 5900

423725 AJ403108 Hs 132127 hypothetical protein LOC57822 420 1 00

423761 NM 006194 Hs 132576 paired box gene 9 1 00 1 00

423787 AJ295745 Hs 236204 nuclear pore complex protein 718 664

423816 AF151064 hypothetical protein 1 00 4400

423826 U20325 Hs 1707 cocaine- and amphetamine-regulated trans 1 00 1 00

423849 AL157425 Hs 133315 Homo sapiens mRNA, cDNA DKFZp761 J1324 (f 1 00 1 00

423887 AL080207 Hs 134585 DKFZP434G232 protein 1 00 1 00

423934 U89995 Hs 159234 forkhead box E1 (thyroid transcription f 31 33 31 00

423954 AW753164 Hs 288604 KIAA1632 protein 581 1087

423961 D13666 Hs 136348 osteoblast specific factor 2 (fasciclm 355 330

424012 AW368377 Hs 137569 tumor protein 63 kDa with strong homolog 23342 6800

424016 AW163729 Hs 6140 hypothetical protein MGC15730 093 1 01

424028 AF055084 Hs 153692 Homo sapiens cDNA FLJ14354 fis, clone Y7 21 30 5200

424046 AF027866 Hs 138202 serine (orcysteme) proteinase inhibito 1 00 1 00

424086 AI351010 Hs 102267 lysyl oxidase 21 91 7000

424098 AF077374 Hs 139322 small proline πch protein 3 13782 5400

424120 T80579 Hs 290270 ESTs 1 00 1 00

424165 AW582904 Hs 142255 islet amyloid polypeptide 1 00 3400

424200 AA337221 gb EST41944 Endo etπal tumor Homo sapie 1306 4800

424279 L29306 Hs 171814 tryptophan hydroxylase (tryptophan 5-mon 1 00 1 00

424308 AW975531 Hs 154443 minichromosome maintenance deficient (S 16458 8700

424326 NM 014479 Hs 145296 dismtegπn protease 5372 30200

424340 AA339036 Hs 7033 ESTs 088 1 15 424351 BE622117 Hs.145567 hypothetical protein 0.93 1.03

424364 AW383226 Hs.201189 ESTs, Weakly similar to G01763 alrophin- 7.02 3.24

424381 AA285249 Hs.146329 pratein kinase Chk2 95.55 92.00

424411 NM 005209 Hs.146549 crystallin, beta A2 1.63 3.25

424420 BE614743 Hs.146688 prostaglandin E synthase 1.63 1.33

424441 X14850 Hs.147097 H2A histone family, member X 1.82 1.29

424502 AF242388 Hs.149585 lengsin 1.00 1.00

424503 X06256 Hs.149609 integrin, alpha 5 (fibronectin receptor, 1.02 2.24

424513 BE385854 Hs.149894 mitochondria! translational initiation f 1.00 17.00

424539 L02911 Hs.150402 Activin A receptor, type I (ACVR1) (ALK 32.46 108.00

424568 AF005418 Hs.150595 cytochrome P450, subfamily XXVIA, polype 3.40 2.58

424602 AK002055 Hs.151046 hypothetical protein FLJ11193 31.87 25.00

424629 M90656 Hs.151393 glutamate-cysteine ligase, catalytic sub 3.58 2.37

424645 NM 014682 Hs.151449 KIAA0535 gene product 1.00 1.00

424687 J05070 Hs.151738 matrix metalloproteinase 9 (gelatinase B 2.12 2.23

424717 AW992292 Hs.152213 wingless-type MMTV integration site fami 1.00 1.00

424834 AK001432 Hs.153408 Homo sapiens cDNA FLJ10570 fis, clone NT 56.19 12.00

424840 D79987 Hs.153479 extra spindle poles, S. cerevisiae, homo 2.65 1.30

424867 AI024860 Hs.153591 Not56 (D. melanogaster)-like protein 1.23 1.05

424905 NM 002497 Hs.153704 NIMA (never in mitosis gene a)-related k 21.35 1.00

424979 D87989 Hs.154073 UDP-galactose transporter related 1.36 1.35

424999 AW953120 gb:EST365190 MAGE resequences, MAGB Homo 1.24 1.41

425048 H05468 Hs.164502 ESTs 1.00 11.00

425057 AA826434 Hs.1619 achaete-scute complex (Drosophila) homol 7.46 87.00

425081 X74794 Hs.154443 minichromosome maintenance deficient (S. 2.52 3.82

425118 AU076611 Hs.154672 methylene tetrahydrofolate dehydrogenase 4.84 4.03

425159 NM_004341 Hs.154868 carbamoyl-phosphate synthetase 2, aspart 3.62 2.73

425202 AW962282 Hs.152049 ESTs, Weakly similar to 138022 hypotheti 1.00 53.00

425234 AW152225 Hs.165909 ESTs, Weakly similar to 138022 hypotheti 100.77 44.00

425236 AW067800 Hs.155223 stanniocalcin 2 3.30 2.90

425245 AI751768 Hs.155314 KIAA0095 gene product 1.91 2.32

425247 NM 05940 Hs.155324 matrix metalloproteinase 11 (stromelysin 1.41 1.49

425266 J00077 Hs.155421 alpha-fetoprotein 1.00 68.00

425274 BE281191 Hs.155462 minichromosome maintenance deficient (mi 1.97 1.63

425322 U63630 Hs.155637 protein kinase, DNA-activated, catalytic 141.49 123.00

425349 AA425234 Hs.79886 ribose 5-phosphate isomerase A (ribose 5 1.00 84.00

425371 D49441 Hs.155981 mesothelin 0.87 1.59

425397 J04088 Hs.156346 topoisomerase (DNA) II alpha (170kD) 14.90 5.76

425420 BE536911 Hs.234545 hypothetical protein NUF2R 1.00 1.00

425424 NM 004954 Hs.157199 ELKL motif kinase 10.58 9.74

425483 AF231022 Hs.158159 FAT tumor suppressor (Drosophila) homolo 1.74 1.40

425566 AW162943 Hs.250618 UL16 binding protein 2 1.49 1.14

425580 L11144 Hs.1907 galanin 53.29 233.00

425650 NM_001944 Hs.1925 desmoglein 3 (pemphigus vulgaris antigen 33.45 1.00

425692 D90041 Hs.155956 N-acetyltransferase 1 (arylamine N-acety 1.00 55.00

425695 NM 005401 Hs.159238 protein tyrosine phosphatase, non-recept 1.00 10.00

425734 AF056209 Hs.159396 peptidylglycine alpha-amidating monooxyg 1.00 41.00

425776 U25128 Hs.159499 parathyroid hormone receptor 2 1.00 48.00

425810 AI923627 Hs.31903 ESTs 27.39 98.00

425811 AL039104 Hs.159557 karyopherin alpha 2 (RAG cohort 1, impor 1.99 1.58

425849 AI077288 Hs.296323 serum/glucocorticoid regulated kinase 71.16 3.42

425852 AK001504 Hs.159651 death receptor 6, TNF superfamily member 1.35 1.34

426067 AA401369 Hs.190721 ESTs 1.01 17.00

426088 AF038007 Hs.166196 ATPase, Class I, type 8B, member 1 26.26 47.00

426215 AW067800 Hs.155223 stanniocalcin 2 1.91 2.90

426227 U67058 Hs.154299 Human proteinase activated receptor-2 mR 22.40 25.00

426269 H15302 Hs.168950 Homo sapiens mRNA; cDNA DKFZp566A1046 (f 1.00 1.00

426283 NM_003937 Hs.169139 kynureninase (L-kynurenine hydrolase) 91.39 229.00

426329 AL389951 Hs.271623 nucleoporiπ 50kD 4.34 4.08

426427 M86699 Hs.169840 TTK protein kinase 7.02 1.00

426432 AF001601 Hs.169857 paraoxonase 2 1.16 1.68

426440 BE382756 Hs.169902 solute carrier family 2 (facilitated glu 2.59 1.71

426459 AF151812 Hs.169992 hypothetical 43.2 Kd protein 1.56 1.66

426471 M22440 Hs.170009 transforming growth factor, alpha 20.60 26.00

426496 D31765 Hs.170114 KIAA0061 protein 9.81 22.00

426501 AA401369 Hs.190721 ESTs 19.23 17.00

426514 BE616633 Hs.170195 bone morphogenetic protein 7 (osteogenic 103.74 41.00

426536 AI949749 Hs.44441 ESTs 4.65 23.00

426572 AB037783 Hs.170623 hypothetical protein FLJ11183 1.00 43.00

426682 AV660038 Hs.2056 UDP glycosyltransferase 1 family, polype 160.06 8.00

426691 NMJ06201 Hs.171834 PCTAIRE protein kinase 1 1.51 1.35

426746 J03626 Hs.2057 uridine monophosphate synthetase (orotat 2.13 1.68

426752 X69490 Hs.172004 titin 0.02 5.14

426784 U03749 Hs.172216 chromogranin A (parathyroid secretory pr 1.72 1.71

426807 AA385315 Hs.156682 ESTs 1.30 1.64

426812 AF105365 Hs.172613 solute carrier family 12 (potassium/chlo 1.47 1.53

426814 AF036943 Hs.172619 myelin transcription factor 1-like 1.00 1.00

426831 BE296216 Hs.172673 S-adenosylhomocyεteine hydrolase 1.51 1.25

426897 AA401369 Hs.190721 ESTs 141.56 17.00

426925 NMJ01196 Hs.315689 Homo sapiens cDNA: FLJ22373 fis, clone H 32.61 38.00

426935 NM 00088 Hs.172928 collagen, type 1, alpha 1 2.65 3.16

426964 AA393739 Hs.287416 Homo sapiens cDNA FLJ11439 fis, clone HE 1.97 3.49

426966 AI493134 sclerostin 1.00 1.00

426991 AK001536 Homo sapiens cDNA FLJ10674 fis, clone NT 3.39 2.28

427099 AB032953 Hs.173560 odd Oz/ten-m homolog 2 (Drosophila, mous 4.24 17.00 427239 BE270447 Hs.174070 ubiquitiπ carrier protein 1.58 1.05

427260 AA663848 gb:ae70b06.s1 Stratagene schizo brain S1 1.34 1.60

427281 AA906147 Hs.102869 ESTs 1.00 66.00

427335 AA448542 Hs.251677 G antigen 7B 51.83 4.00

427354 T57896 Hs.191095 ESTs 1.17 1.95

427356 AW023482 Hs.97849 ESTs 7.31 41.00

427376 AA401533 Hs.19440 ESTs 1.00 57.00

427383 NM 005411 Hs.177582 surfactant, pulmonary-associated protein 0.42 1.32

427427 AF077345 Hs.177936 lectin, superfamily member 1 (cartilage- 1.00 20.00

427441 AA412605 Hs.343879 SPANX family, member C 1.00 1.00

427445 X80818 Hs.178078 glutamate receptor, metabotropic 4 0.97 1.03

427505 AA361562 Hs.178761 26S proteasome-associated padl homolog 4.60 4.04

427510 Z47542 Hs.179312 small nuclear RNA activating complex, po 22.00 45.00

427528 AU077143 Hs.179565 minichromosome maintenance deficient (S. 97.45 92.00

427546 AA188763 Hs.36793 hypothetical protein FLJ23188 1.50 3.24

427562 R56424 Hs.26534 ESTs 6.81 40.00

427585 D31152 Hs.179729 collagen, type X, alpha 1 (Sch id metaph 69.91 62.00

427660 AI741320 Hs.114121 Homo sapiens cDNA: FLJ23228 fis, clone C 2.70 49.00

427666 AI791495 Hs.180142 cal odulin-like skin protein 1.37 1.88

427668 AA298760 Hs.180191 hypothetical protein FLJ 14904 29.55 67.00

427677 NM 007045 Hs.180296 FGFR1 oncogene partner 3.52 2.63

427701 AA411101 Hs.243886 nuclear autoantigenic sperm protein (his 7.41 34.00

427711 M31659 Hs.180408 solute carrier family 25 (mitochondrial 15.84 70.00

427719 AI393122 Hs.134726 ESTs 7.03 4.52

427722 AK000123 Hs.180479 hypothetical protein FLJ20116 2.92 1.74

427747 AW411425 Hs.180655 seriπe/threonine kinase 12 1.76 1.26

427912 AL022310 Hs.181097 tumor necrosis factor (ligand) superfami 9.63 59.00

427961 AW293165 Hs.143134 ESTs 41.97 118.00

428004 AA449563 Hs.151393 glutamate-cysteine ligase, catalytic sub 23.82 1.00

428023 AL038843 Homo sapiens cDNA: FLJ23602 fis, clone L 1.40 1.33

428046 AW812795 Hs.337534 ESTs, Moderately similar to I38022 hypot 96.28 167.00

428093 AW594506 Hs.104830 ESTs 1.25 1.29

428098 AU077258 Hs.182429 protein disulfide isomerase-related prot 1.86 1.60

428129 AI244311 Hs.26912 ESTs 1.00 42.00

428169 AI928984 Hs.182793 golgi phosphoprotein 2 2.76 2.11

428182 BE386042 Hs.293317 ESTs, Weakly similar to GGC1_HUMAN G ANT 1.00 1.00

428227 AA321649 Hs.2248 small inducible cytokine subfamily B (Cy 85.59 181.00

428242 H55709 Hs.2250 leukemia inhibitory factor (cholinergic 8.57 21.64

428330 L22524 Hs.2256 matrix metalloproteinase 7 (malrilysin, 7.77 15.90

428434 AI909935 Hs.65551 Homo sapiens, Similar to DNA segment, Ch 0.58 1.43

428450 NM.014791 Hs.184339 KIAA0175 gene product 237.53 204.00

428471 X57348 Hs.184510 stratifin 6.00 4.60

428479 Y00272 Hs.334562 cell division cycle 2, G1 to S and G2 to 56.54 16.00

428484 AF104032 Hs.184601 solute carrier family 7 (cationic amino 3.53 2.15

428505 AL035461 Hs.2281 chromogranin B (secretogranin 1) 1.00 1.00

428532 AF157326 Hs.184786 TBP-interacting protein 1.00 58.00

428645 AA431400 Hs.98729 ESTs, Weakly similar to 2017205A dihydra 1.00 16.00

428664 AK001666 Hs.189095 similar to SALL1 (sal (Drosophila)-like 1.00 1.00

428698 AA852773 Hs.334838 KIAA1866 protein 187.37 255.00

428728 NM_016625 Hs.191381 hypothetical protein 47.24 80.00

428748 AW593206 Hs.98785 Ksp37 protein 1.00 87.00

428758 AA433988 Hs.98502 hypothetical protein FLJ14303 1.06 1.13

428771 AB028992 Hs.193143 KIAA1069 protein 1.98 92.00

428801 AW277121 Hs.254881 ESTs 1.67 6.15

428810 AF068236 Hs.193788 nitric oxide synthase 2A (inducible, hep 1.03 1.27

428839 AI767756 Hs.82302 Homo sapiens cDNA FLJ14814 fis, clone NT 124.17 43.00

428845 AL157579 Hs.153610 KIAA0751 gene product 1.00 1.00

428959 AF100779 Hs.194680 WNT1 inducible signaling pathway protein 15.16 27.00

428969 AF120274 Hs.194689 artemin 1.36 1.24

429038 AL023513 Hs.194766 seizure related gene 6 (mouse)-like 0.97 3.31

429065 AI753247 Hs.29643 Homo sapiens cDNA FLJ13103 fis, clone NT 6.82 16.47

429164 AI688663 Hs.116586 ESTs 19.08 67.00

429170 NM 001394 Hs.2359 dual specificity phosphatase 4 16.18 105.00

429183 AB014604 Hs.197955 KIAA0704 protein 79.72 104.00

429201 X03178 Hs.198246 group-specific component (vitamin D bind 1.00 1.00

429211 AF052693 Hs.198249 gap junction protein, beta 5 (connexin 3 1.33 1.09

429220 AW207206 ESTs 1.00 7.00

429228 AI553633 Hs.326447 ESTs 39.47 29.25

429259 AA420450 Hs.292911 ESTs, Highly similar to S60712 band-6-pr 2.01 1.18

429263 AA019004 Hs.198396 ATP-binding cassette, sub-family A (ABC1 1.07 1.00

429276 AF056085 Hs.198612 G protein-coupled receptor 51 3.70 142.00

429359 W00482 Hs.2399 matrix metalloproteinase 14 (membrane-in 1.30 1.94

429412 NMJ06235 Hs.2407 POU domain, class 2, associating factor 94.09 86.00

429413 NM 14058 Hs.201877 DESC1 protein 41.91 10.00

429486 AF155827 Hs.203963 hypothetical protein FLJ 10339 12.19 1.00

429504 X99133 Hs.204238 lipocalin 2 (oncogene 24p3) 1.61 1.08

429538 BE182592 Hs.11261 small proline-rich protein 2A 4.43 2.90

429547 AA401369 Hs.190721 ESTs 1.06 17.00

429551 AW450624 Hs.220931 ESTs 2.89 65.00

429563 BE619413 Hs.2437 eukaryotic translation initiation factor 1.49 1.37

429597 NM_003816 Hs.2442 a disintegrin and metalloproteinase doma 61.66 100.00

429610 AB024937 Hs.211092 LUNX protein; PLUNC (palate lung and nas 1.59 1.69

429612 AF062649 Hs.252587 pituitary tumor-transforming 1 2.78 1.74

429616 AI982722 Hs.120845 ESTs 1.00 1.00

429656 X05608 Hs.211584 neurofilament, light polypeptide (68kD) 1.00 4.00 429663 M68874 Hs.211587 phospholipase A2, group IVA (cytosolic, 69.95 104.00

429736 AF125304 Hs.212680 tumor necrosis factor receptor superfami 1.25 1.21

429782 NM 005754 Hs.220689 Ras-GTPase-activating protein SH3-domain 1.00 7.00

429903 AL134197 Hs.93597 cyclin-dependent kinase 5, regulatory su ! 11.80 1.00

429918 AW873986 Hs.119383 ESTs 1.00 78.00

429978 AA249027 ribosomal protein S6 1.98 3.09

429986 AF092047 Hs.227277 sine oculis ho eobox (Drosophila) homolo 1.00 48.00

430044 AA464510 Hs.152812 ESTs 69.27 59.00

430114 AA847744 Hs.99640 ESTs 1.00 1.00

430134 BE380149 Hs.105223 ESTs, Weakly similar to T33188 hypotheti 1.00 51.00

430147 R60704 Hs.234434 hairy/enhancer-of-split related with YRP 1.10 2.22

430287 AW182459 Hs.125759 ESTs, Weakly similar to LEU5_HUMAN LEUKE 1.00 127.00

430294 AI538226 Hs.32976 guanine nucleotide binding protein 4 3.80 1.47

430300 U60805 Hs.238648 oncostatin M receptor 1.00 35.00

430315 NM 004293 Hs.239147 guanine dea inase 92.31 28.00

430337 M36707 Hs.239600 calmodulin-like 3 1.18 1.08

430378 Z29572 Hs.2556 tumor necrosis factor receptor superfami 5.28 66.00

430388 AA356923 Hs.240770 nuclear cap binding protein subunit 2, 2 16.76 38.00

430393 BE185030 Hs.241305 estrogen-responsive B box protein 1.63 1.50

430439 AL133561 DKFZP434B061 protein 1.00 1.00

430451 AA836472 Hs.297939 cathepsin B 1.64 2.12

430454 AW469011 Hs.105635 ESTs 63.35 44.00

430466 AF052573 Hs.241517 polymerase (DNA directed), theta 2.47 1.91

430481 AA479678 Hs.203269 ESTs, Moderately similar to ALU8_HUMAN A 1.00 31.00

430486 BE062109 Hs.241551 chloride channel, calcium activated, fam 12.28 41.00

430508 AI015435 Hs.104637 ESTs 4.75 7.27

430533 AA480895 Hs.57749 ESTs, Weakly similar to T17288 hypotheti 1.00 1.00

430563 AF146074 Hs.108660 ATP-binding cassette, sub-family C (CFTR 1.00 1.59

430677 Z26317 Hs.94560 desmoglein 2 1.72 1.30

430678 AA401369 Hs.190721 ESTs 0.90 17.00

430686 NM 001942 Hs.2633 desmoglein 1 1.00 1.00

430788 AI742925 Hs.7179 ESTs, Weakly similar to 2004399A chromos 1.62 1.84

430890 X54232 Hs.2699 glypican 1 1.58 1.40

430935 AW072916 zinc finger protein 131 (clone pHZ-10) 90.28 132.00

430985 AA490232 Hs.27323 ESTs, Weakly similar to 178885 serine/th 0.94 1.28

431009 BE149762 Hs.48956 gap junction protein, beta 6 (connexin 3 60.25 28.00

431089 BE041395 ESTs, Weakly similar to unknown protein 23.32 941.00

431092 AI332764 Hs.125757 ESTs 13.46 63.00

431124 AF284221 Hs.59506 doublesex and mab-3 related transcriptio 49.43 62.00

431164 AA493650 Hs.94367 Homo sapiens cDNA: FLJ23494 fis, clone L 0.44 2.20

431211 M86849 Hs.323733 gap junction protein, beta 2, 26kD (conn 182.26 101.00

431221 AW207837 Hs.286145 SRB7 (suppressor of RNA polymerase B, ye 4.15 13.97

431277 AA501806 Hs.345824 ESTs 1.00 86.00

431322 AW970622 gb:EST382704 MAGE resequences, MAGK Homo 40.55 200.00

431342 AW971018 Hs.21659 ESTs 1.00 53.00

431384 BE158000 Hs.285026 gb:MR2-HT0377-150200-202-e03 HT0377 Homo 0.94 1.14

431462 AW583672 Hs.256311 granin-like neuroendocrine peptide precu 1.30 1.25

431494 AA991355 Hs.298312 hypothetical protein DKFZp434A1315 3.90 26.00

431515 NM_012152 Hs.258583 endothelial differentiation, lysophospha 1.41 1.87

431548 AI834273 Hs.9711 novel protein 5.66 15.00

431630 NM 002204 Hs.265829 integrin, alpha 3 (antigen CD49C, alpha 0.99 1.44

431745 AW972448 Hs.163425 ESTs 0.99 3.51

431770 BE221880 Hs.268555 5'-3' exoribonuclease 2 67.12 91.00

431830 Y16645 Hs.271387 small inducible cytokine subfamily A (Cy 3.36 4.71

431846 BE019924 Hs.271580 uroplakiπ 1B 4.49 2.51

431890 X17033 Hs.271986 integrin, alpha 2 (CD49B, alpha 2 subuni 2.20 3.32

431934 AB031481 Hs.272214 STG protein 1.01 1.04

431958 X63629 Hs.2877 cadherin 3, type 1, P-cadherin (placenta 51.17 46.35

432006 AL137382 Hs.272320 Homo sapiens mRNA; cDNA DKFZp434L1226 (f 0.94 1.65

432023 R43020 Hs.236223 EST 0.94 47.00

432201 AI538613 Hs.298241 Transmembrane protease, serine 3 1.10 2.24

432210 AI567421 Hs.273330 Homo sapiens, clone IMAGE:3544662, mRNA, 1.42 1.45

432226 AW182766 Hs.273558 phosphate cytidylyltransferase 1, choliπ 1.00 1.00

432239 X81334 Hs.2936 matrix metalloproteinase 13 (coUagenase 18.67 1.00

432265 BE382679 Hs.285753 SCG10-like-protein 1.09 1.21

432281 AK001239 Hs.274263 hypothetical protein FLJ10377 40.98 58.00

432365 AK001106 Hs.274419 hypothetical protein FLJ 10244 1.00 214.00

432374 W68815 Hs.301885 Homo sapiens cDNA FU11346 fis, clone PL 157.34 37.00

432375 BE536069 Hs.2962 S100 calcium-binding protein P 1.65 1.06

432407 AA221036 gb:zr03f12.r1 Stratagene NT2 neuronal pr 73.71 75.00

432441 AW292425 Hs.163484 ESTs 56.35 72.00

432489 AI804855 Hs.207530 ESTs 1.00 24.00

432543 AA552690 Hs.152423 Homo sapiens cDNA: FLJ21274 fis, clone C 137.72 98.00

432552 AI537170 Hs.173725 ESTs, Weakly similar to ALU8.HUMAN ALU S 1.00 31.00

432583 AW023624 Hs.162282 potassium channel TASK-4; potassium chan 0.27 35.18

432606 NM 002104 Hs.3066 granzyme K (serine protease, granzyme 3; 2.87 6.22

432625 AI243596 Hs.94830 ESTs, Moderately similar to T03094 A-kin 26.63 56.00

432653 N62096 Hs.293185 ESTs, Weakly similar to JC7328 amino aci 1.92 5.29

432677 NM 004482 Hs.278611 UDP-N-acetyl-alpha-D-galactosamine:polyp 1.00 48.00

432715 AA247152 Hs.200483 ESTs, Weakly similar to KIAA1074 protein 45.13 31.00

432753 NM 014075 Hs.336938 Homo sapiens PRO0593 mRNA, complete eds 1.00 68.00

432788 AA521091 Hs.178499 Homo sapiens cDNA: FLJ23117 fis, clone L 2.69 3.67

432842 AW674093 Hs.334822 hypothetical protein MGC4485 1.22 1.34

432867 AW016936 Hs.233364 ESTs 1.00 1.00

432917 NM 014125 Hs.241517 PRO0327 protein 10.25 6.62 432920 U37689 Hs.3128 polymerase (RNA) II (DNA directed) polyp 1.44 1.30

433001 AF217513 Hs.279905 clone HQ0310 PRO0310p1 154.79 85.64

433023 AW864793 Hs.87409 thrombospondin 1 20.96 100.00

433042 AW193534 Hs.281895 Homo sapiens cDNA FLJ11660 fis, clone HE 1.00 10.00

433091 Y12642 Hs.3185 lymphocyte antigen 6 complex, locus D 1.20 1.09

433159 AB035898 Hs.150587 kinesin-like protein 2 13.82 39.00

433183 AF231338 Hs.222024 transcription factor BMAL2 1.00 69.00

433258 AA622788 Hs.203613 ESTs, Weakly similar to ALUB_HUMAN III! 1.00 1.25

433409 AI278802 Hs.25661 ESTs 44.81 117.00

433437 U20536 Hs.3280 caspase 6, apoptosis-related cysteine pr 70.39 105.00

433485 AI493076 Hs.201967 aldo-keto reductase family 1, member C2 11.55 2.00

433537 AI733692 Hs.112488 ESTs 8.66 55.00

433547 W04978 Hs.303023 beta tubulin 1, class VI 25.16 83.00

433556 W56321 Hs.111460 calcium/calmodulin-dependent protein kin 1.00 19.00

433647 AA603367 Hs.222294 ESTs 20.30 49.00

433658 L03678 Hs.156110 immunoglobulin kappa constant 5.92 10.03

433800 AI094221 Hs.135150 lung type-l cell membrane-associated gly 2.29 2.22

433819 AW511097 Hs.112765 ESTs 3.71 8.00

433862 D86960 Hs.3610 KIAA0205 gene product 62.08 104.00

433980 AA137152 Hs.286049 phosphoserine aminotransferase 108.91 47.00

434088 AF116677 Hs.249270 hypothetical protein PR01966 1.00 1.00

434094 AA305599 Hs.238205 hypothetical protein PRO2013 121.27 87.00

434105 AW952124 Hs.13094 presenilins associated rhomboid-like pro 1.22 1.23

434217 AW014795 Hs.23349 ESTs 14.11 57.00

434340 AI193043 Hs.128685 ESTs, Weakly similar to T17226 hypotheti 2.10 2.56

434360 AA401369 Hs.190721 ESTs 40.98 17.00

434414 AI798376 gb:tr34b07.x1 NCI_CGAP_Ov23 Homo sapiens 1.48 1.56

434424 AI811202 Hs.325335 Homo sapiens cDNA: FLJ23523 fis, clone L 1.00 64.00

434467 BE552368 Hs.231853 Homo sapiens cDNA FLJ13445 fis, clone PL 54.91 85.00

434551 BE387162 Hs.280858 ESTs, Highly similar to A35661 DNA excis 2.46 2.00

434627 AI221894 Hs.39311 ESTs 1.00 1.00

434699 AA643687 Hs.149425 Homo sapiens cDNA FLJ11980 fis, clone HE 1.00 23.00

434769 AA648884 Hs.134278 Homo sapiens cDNA FLJ12676 fis, clone NT 7.08 56.00

434792 AA649253 Hs.132458 ESTs 8.52 44.00

434808 AF155108 Hs.256150 Homo sapiens, Similar to RIKEN cDNA 2810 11.33 1.00

434828 D90070 Hs.96 phorbol-12-myristate-13-acetate-induced 1.00 1.00

434876 AF160477 Hs.61460 Ig superfamily receptor LNIR 1.25 1.29

434891 AA814309 Hs.123583 ESTs 1.00 6.00

434928 AW015595 Hs.4267 Homo sapiens clones 24714 and 24715 mRNA 1.00 1.00

435013 H91923 Hs.110024 Target CAT 1.26 1.10

435066 BE261750 Hs.4747 dyskeratosis congeπita 1, dyskerin 1.69 1.37

435087 AW975241 Hs.23567 ESTs 1.00 1.00

435099 AC004770 Hs.4756 flap structure-specific endonuclease 1 2.90 1.93

435159 AA668879 Hs.116649 ESTs 1.00 1.00

435205 X54136 Hs.181125 immunoglobulin lambda locus 1.02 1.46

435232 NM 001262 Hs.4854 cyclin-dependent kinase inhibitor 2C (p1 2.04 2.70

435304 H10709 Hs.269524 ESTs 27.58 139.00

435313 AI769400 Hs.189729 ESTs 1.00 14.00

435505 AF200492 Hs.211238 interleukin-1 homolog 1 1.00 38.00

435509 AI458679 Hs.181915 ESTs 1.00 1.00

435525 AI831297 Hs.123310 ESTs 1.00 56.00

435532 AW291488 Hs.117305 Homo sapiens, clone IMAGE:3682908, mRNA 1.00 2.00

435550 AI224456 Hs.324507 H.sapiens polyA site DNA 3.42 3.92

435602 AF217515 Hs.283532 uncharacterized bone marrow protein BM03 3.95 1.80

435766 R11673 Hs.186498 ESTs 1.00 28.00

435793 AB037734 Hs.4993 KIAA1313 protein 23.68 42.00

436069 AI056879 Hs.263209 ESTs 1.00 58.00

436170 AW450381 Hs.14529 ESTs 1.00 18.00

436211 AK001581 Hs.334828 hypothetical protein FLJ10719; KIAA1794 5.84 22.00

436213 AA325512 Hs.71472 hypothetical protein FLJ10774; KIAA1709 1.42 1.27

436217 T53925 Hs.107 fibrinogen-like 1 57.97 31.00

436238 AK002163 Hs.301724 hypothetical protein FLJ11301 2.51 1.71

436251 BE515065 Hs.296585 nucleolar protein (KKE/D repeat) 2.33 1.64

436291 BE568452 Hs.344037 protein regulator of cytokinesis 1 108.99 52.00

436302 AL355841 Hs.99330 hypothetical protein FLJ23588 0.75 2.81

436396 AW992292 Hs.152213 wingless-type MMTV integration site fami 60.01 1.00

436414 BE264633 Hs.143638 WD repeat domain 4 2.50 2.19

436419 AI948626 Hs.171356 ESTs 0.95 1.33

436443 AW138211 Hs.128746 ESTs 1.12 9.26

436474 AJ270693 Hs.199887 ESTs 1.00 1.00

436481 AA379597 Hs.5199 HSPC150 protein similar to ubiquitin-con 3.28 1.56

436486 AA742221 Hs.120633 ESTs 1.00 19.00

436511 AA721252 Hs.291502 ESTs 16.76 14.00

436553 X57809 Hs.181125 immunoglobulin lambda locus 1.08 1.74

436557 W15573 Hs.5027 ESTs, Weakly similar to A47582 B-cell gr 19.20 9.75

436608 AA628980 down syndrome critical region protein DS 33.92 25.00

436667 AW025183 Hs.127680 ESTs 0.89 1.19

436771 AW975687 Hs.292979 ESTs 1.00 10.00

436839 AA401369 Hs.190721 ESTs 1.00 17.00

436887 AW953157 Hs.193235 hypothetical protein DKFZp547D155 1.06 1.15

436944 AW268614 Hs.5840 ESTs 1.00 1.00

436961 AW375974 Hs.156704 ESTs 25.13 25.00

436972 AA284679 Hs.25640 claudin 3 1.59 1.46

437016 AU076916 Hs.5398 guanine monphosphate synthetase 2.35 1.78

437044 AL035864 Hs.69517 cDNA for differentially expressed C016 g 1.34 1.13 437181 AI306615 Hs.125343 ESTs, Weakly similar to KIAA0768 protein 1.00 17.00

437204 AL110216 Hs.22826 ESTs, Weakly similar to 155214 salivary 40.55 82.00

437205 AL110232 Hs.279243 Homo sapiens mRNA; cDNA DKFZp564D2071 (f 1.00 112.00

437259 A1377755 Hs.120695 ESTs 1.00 205.00

437270 R18087 Hs.323769 cisplatin resistance related protein CRR 1.56 1.54

437271 AL137445 Hs.28846 Homo sapiens mRNA; cDNA DKFZp5660134 (fr 113.25 125.00

437370 AL359567 Hs.161962 Homo sapiens mRNA; cDNA DKFZp547D023 (fr 1.82 4.57

437390 AI125859 Hs.112607 ESTs 1.35 1.75

437412 BE069288 Hs.34744 Homo sapiens mRNA; cDNA DKFZp547C136 (fr 3.58 3.20

437435 AI306152 Hs.27027 hypothetical protein DKFZp762H1311 3.03 1.08

437444 H46008 Hs.31518 ESTs 1.00 39.00

437568 AI954795 Hs.156135 ESTs 1.00 19.00

437623 D63880 Hs.5719 chromosome condensation-related SMC-asso 1.95 1.57

437789 AI581344 Hs.127812 ESTs, Weakly similar to T17330 hypotheti 1.00 3.00

437814 AI088192 Hs.135474 ESTs, Weakly similar to DDX9_HUMAN ATP-D 1.00 45.00

437840 AA884836 Hs.292014 ESTs 1.07 1.78

437852 BE001836 Hs.256897 ESTs, Weakly similar to dJ365012.1 [H.sa 1.68 3.26

437879 BE262082 Hs.5894 hypothetical protein FLJ10305 1.87 2.52

437915 AI637993 Hs.202312 Homo sapiens clone N11 NTera2D1 teratoca 74.05 35.00

437916 BE566249 Hs.20999 hypothetical protein FLJ23142 23.15 89.00

437937 AI917222 Hs.121655 ESTs 1.00 1.00

437942 AI888256 Hs.307526 ESTs 12.28 31.00

438091 AW373062 nuclear receptor subfamily 1, group I, m 1.53 10.85

438113 AI467908 Hs.8882 ESTs 1.80 2.39

438119 AW963217 Hs.203961 ESTs, Moderately similar to AF116721 89 22.67 36.90

438274 AI918906 Hs.55080 ESTs 1.00 1.00

438378 AW970529 Hs.86434 hypothetical protein FLJ21816 38.92 38.00

438403 AA806607 Hs.292206 ESTs 1.00 1.00

438494 AA908678 Hs.130183 ESTs 2.05 80.00

438546 AW297204 Hs.125811 ESTs 1.00 131.00

438552 AJ245820 Hs.6314 type I transmembrane receptor (seizure-r 1.43 1.45

438702 AI879064 Hs.54618 ESTs 1.00 34.00

438724 AW612553 Hs.114670 Human DNA sequence from clone RP11-16L21 1.33 1.10

438746 AI885815 Hs.184727 Human melanoma-associated antigen p97 (m 2.42 1.59

438779 NMJW3787 Hs.6414 nucleolar protein 4 1.00 18.00

438821 AA826425 Hs.192375 ESTs 2.03 2.57

438885 AI886558 Hs.184987 ESTs 6.42 88.00

438898 AA401369 Hs.190721 ESTs 22.41 17.00

438915 AA280174 Hs.285681 Williams-Beuren syndrome chromosome regi 1.00 1.00

438956 W00847 Hs.135056 Human DNA sequence from clone RP5-850E9 2.20 1.88

439000 AW979121 gb:EST391231 MAGE resequences, MAGP Homo 2.78 4.81

439023 AA745978 Hs.28273 ESTs 1.17 1.31

439024 R96696 Hs.35598 ESTs 1.00 28.00

439128 AI949371 Hs.153089 ESTs 1.00 67.00

439146 AW138909 Hs.156110 immunoglobulin kappa constant 1.38 1.41

439223 AW238299 Hs.250618 UL16 binding protein 2 1.93 1.64

439285 AL133916 hypothetical protein FLJ20093 46.23 139.00

439318 AW837046 Hs.6527 G protein-coupled receptor 56 2.00 2.20

439343 AF086161 Hs.114611 hypothetical protein FLJ11808 6.10 7.37

439394 AA401369 Hs.190721 ESTs 3.39 17.00

439410 AA632012 Hs.188746 ESTs 1.83 3.07

439451 AF086270 Hs.278554 heterochromatin-like protein 1 23.28 52.00

439452 AA918317 Hs.57987 B-cell CLUymphoma 11B (zinc finger pro 18.76 122.00

439453 BE264974 Hs.6566 thyroid hormone receptor interactor 13 2.78 1.56

439477 W69813 Hs.58042 ESTs, Moderately similar to GFR3 HUMAN G 1.22 1.44

439492 AF086310 Hs.103159 ESTs 7.46 39.00

439523 W72348 Hs.185029 ESTs 1.00 1.19

439592 AF086413 Hs.58399 ESTs 1.00 1.00

439606 W79123 Hs.58561 G protein-coupled receptor 87 33.61 1.00

439670 AF088076 Hs.59507 ESTs, Weakly similar to AC0048583 U1 sm 1.00 1.00

439702 AW085525 Hs.134182 ESTs 4.30 10.00

439706 AW872527 Hs.59761 ESTs, Weakly similar to DAPLHUMAN DEATH 86.55 11.00

439738 BE246502 Hs.9598 sema domain, immunoglobulin domain (Ig), 2.36 1.88

439750 AL359053 Hs.57664 Homo sapiens mRNA full length Insert cDN 2.02 6.08

439759 AL359055 Hs.67709 Homo sapiens mRNA full length insert cDN 1.00 21.00

439780 AL109688 gb'.Homo sapiens mRNA full length insert 7.27 25.00

439840 AW449211 Hs.105445 GDNF family receptor alpha 1 1.00 1.00

439926 AW014875 Hs.137007 ESTs 32.58 71.00

439963 AW247529 Hs.6793 platelet-activating factor acetylhydrala 21.28 9.55

439979 AW600291 Hs.6823 hypothetical protein FLJ10430 68.83 61.00

440006 AK000517 Hs.6844 hypothetical protein FLJ20510 1.83 4.02

440028 AW473675 Hs.125843 ESTs, Weakly similar to T17227 hypotheti 1.42 2.54

440106 AA864968 Hs.127699 KIAA1603 protein 1.00 54.00

440138 AB033023 Hs.318127 hypothetical protein FLJ 10201 24.18 52.00

440273 AI805392 Hs.325335 Homo sapiens cDNA: FLJ23523 fis, clone L 3.21 4.72

440289 AW450991 Hs.192071 ESTs 38.63 113.00

440325 NM 003812 Hs.7164 a disintegrin and metalloproteinase doma 62.88 147.00

440492 R39127 Hs.21433 hypothetical protein DKFZp547J036 2.35 3.62

440527 AV657117 Hs.184164 ESTs, Moderately similar to S65657 alpha 10.84 57.00

440659 AF134160 Hs.7327 claudin 1 3.18 2.37

440704 M69241 Hs.162 insulin-like growth factor binding prate 2.89 2.09

440943 AW082298 Hs.146161 hypothetical protein MGC2408 2.02 1.41

440994 AI160011 Hs.272068 ESTs 1.29 1.14

441020 AA401369 Hs.190721 ESTs 142.99 17.00

441031 AH 10684 ' Hs.7645 fibrinogen, B beta polypeptide 1.41 99.00 441128 AA570256 ESTs, Weakly similar to T23273 hypotheti 4.13 3.50

441280 W27501 Hs.89605 cholinergic receptor, nicotinic, alpha p 1.00 1.00

441362 BE614410 Hs.23044 RAD51 (S. cerevisiae) homolog (E coli Re 130.23 43.00

441377 BE218239 Hs.202656 ESTs 22.03 1.00

441390 AI692560 Hs.131175 ESTs 3.65 7.70

441497 R51064 Hs.23172 ESTs 1.00 1.00

441525 AW241867 Hs.127728 ESTs 1.53 1.42

441553 AA281219 Hε.121296 ESTs 1.89 1.57

441607 NM_005010 Hs.7912 neuronal cell adhesion molecule 1.47 2.11

441633 AW958544 Hs.112242 normal mucosa of esophagus specific 1 216.22 363.00

441636 AA081846 Hs.7921 Homo sapiens mRNA; cDNA DKFZp566E183 (fr 2.31 2.05

441737 X79449 Hs.7957 adenosine dea inase, RNA-specific 1.30 1.49

441790 AA401369 Hs.190721 ESTs 44.15 17.00

441801 AW242799 Hs.86366 ESTs 1.00 1.00

441919 AI553802 Hs.128121 ESTs 1.00 122.00

441937 R41782 Hs.22279 ESTs 0.86 1.37

441954 AI744935 Hs.8047 Fanconi anemia, complementation group G 1.48 1.39

442025 AW887434 Hs.11810 CDA11 protein 1.00 46.00

442029 AW956698 Hs.14456 neural precursor cell expressed, develop 9.92 45.00

442072 A1740832 Hs.12311 Homo sapiens clone 23570 mRNA sequence 25.05 77.00

442108 AW452649 Hs.166314 ESTs 3.61 3.14

442117 AW664964 Hs.128899 ESTs 3.00 5.49

442137 AA977235 Hs.128830 ESTs, Weakly similar to Z192_HUMAN ZINC 1.00 1.00

442159 AW163390 Hs.278554 heterochromatin-like protein 1 1.92 1.66

442179 AA983842 Hs.333555 chromosome 2 open reading frame 2 27.22 50.00

442328 AI952430 Hs.150614 ESTs, Weakly similar to ALU4_HUMAN ALU S 5.00 3.42

442432 BE093589 Hs.38178 hypothetical protein FLJ23468 181.59 76.00

442530 AI580830 Hε.176508 Homo sapiens cDNA FLJ14712 fis, clone NT 10.59 144.00

442547 AA306997 Hs.217484 ESTs, Weakly similar to ALU1 HUMAN ALU S 109.23 98.00

442556 AL137761 Hs.8379 Homo sapiens mRNA; cDNA DKFZp586L2424 (f 1.00 53.00

442619 AA447492 Hs.20183 ESTs, Weakly similar to AF1647931 prate 29.02 50.00

442710 AI015631 Hs.23210 ESTs 1.00 19.00

442717 R88362 Hs.180591 ESTs, Weakly similar to T23976 hypotheti 1.00 5.00

442875 BE623003 Hs.23625 Homo sapiens clone TCCCTA00142 mRNA sequ 22.85 50.00

442914 AW188551 Hs.995 9 hypothetical protein FLJ 14007 25.33 82.00

442932 AA457211 Hs.8858 bramodomaϊn adjacent to zinc finger doma 3.18 4.41

442942 AW167087 Hs.131562 ESTs 8.45 64.00

443068 AI188710 ESTs 1.00 27.00

443204 AW205878 Hs.29643 Homo sapiens cDNA FLJ13103 fis, clone NT 1.00 24.00

443211 AI128388 Hs.143655 ESTs 12.42 2.00

443247 BE614387 Hs.333893 c-Myc target JP01 128.84 96.00

443324 R44013 Hs.164225 ESTs 0.02 4.59

443383 AI792453 Hs.166507 ESTs 1.00 47.00

443400 R28424 Hs.250648 ESTs 18.52 61.00

443426 AF098158 Hs.9329 chromosome 20 open reading frame 1 4.02 1.75

443572 AA025610 Hs.9605 cleavage and polyadenylation specific fa 2.98 2.57

443575 AI078022 Hs.269636 ESTs, Weakly similar to ALU HUMAN ALU S 1.00 29.00

443614 AV655386 Hs.7645 fibrinogen, B beta polypeptide 1.00 16.00

443633 AL031290 Hs.9654 similar to pregnancy-associated plasma p 1.00 39.00

443648 A1085377 Hs.143610 ESTs 39.81 70.00

443715 AI583187 Hs.9700 cyclin E1 48.74 7.00

443723 AI144442 Hs.157144 syntaxin 6 1.29 1.30

443802 AW504924 Hs.9805 KIAA1291 protein 1.75 1.61

443859 NMJ13409 Hs.9914 follistatiπ 1.35 1.13

443892 AA401369 Hs.190721 ESTs 1.00 17.00

443947 W24187 gb:zb47f09.r1 Soares_fetal_lung_NbHL19W 1.33 1.64

443991 NMJ02250 Hs.10082 potassium intermediate/small conductance 5.71 6.87

444006 BE395085 Hs.10086 type 1 transmembrane protein Fn14 1.47 1.92

444009 AI380792 Hs.135104 ESTs 1.00 77.00

444017 U04840 Hs.214 neura-oncological ventral antigen 1 1.00 1.00

444127 N63620 Hs.13281 ESTs 1.00 29.00

444129 AW294292 Hs.256212 ESTs 1.00 1.00

444279 U62432 Hs.89605 cholinergic receptor, nicotinic, alpha p 0.60 7.80

444371 BE540274 Hs.239 forkhead box Ml 2.91 1.14

444378 R41339 Hs.12569 ESTs 1.00 1.00

444381 BE387335 Hs.283713 ESTs, Weakly similar to S64054 hypotheti 469.00 556.00

444461 R53734 Hs.25978 ESTs, Weakly similar to 2109260A B cell 12.88 105.00

444471 AB020684 Hs.11217 KIAA0877 protein 24.91 90.00

444489 AI151010 Hs.157774 ESTs 1.00 111.00

444619 BE538082 Hs.8172 ESTs, Moderately similar to A46010 X-lin 1.00 70.00

444665 BE613126 Hs.47783 B aggressive lymphoma gene 30.56 139.00

444707 AI188613 Hs.41690 desmocollin 3 1.00 1.00

444735 BE019923 Hs.243122 hypothetical protein FLJ 13057 similar to 77.02 90.00

444781 NM_014400 Hs.11950 GPI-anchored metastasis-associated prate 1.57 1.31

444783 AK001468 Hs.62180 anillin (Drosophila Scraps homolog), act 77.55 2.00

445236 AK001676 Hs.12457 hypothetical protein FLJ10814 1.00 27.00

445258 AI635931 Hs.147613 ESTs 1.00 73.00

445413 AA151342 Hs.12677 CGI-147 protein 28.14 50.00

445417 AK001058 Hs.12680 Homo sapiens cDNA FLJ10196 fis, clone HE 1.81 2.62

445443 AV653838 Hs.322971 ESTs 1.00 1.00

445462 AA378776 Hs.288649 hypothetical protein MGC3077 2.09 1.70

445517 AF208855 Hs.12830 hypothetical protein 1.87 70.00

445537 AJ245671 Hs.12844 EGF-like-domaϊn, multiple 6 1.71 2.72

445580 AF167572 Hs.12912 skbl (S. pombe) homolog 1.52 1.34

445654 X91247 Hs.13046 thioredoxin reductase 1 1.51 1.52 445669 AI570830 Hs.174870 ESTs 10.95 11.45

445818 BE045321 Hs.136017 ESTs 1.00 1.00

445873 AA250970 Hs.251946 poly(A)-binding protein, cytoplasmic 1-I 49.42 54.00

445885 A1734009 Hs.127699 KIAA1603 protein 1.00 132.00

445898 AF070623 Hs.13423 Homo sapiens clone 24468 mRNA sequence 1.00 1.00

445903 AI347487 Hs.132781 class 1 cytokine receptor 1.00 36.00

445932 BE046441 Hs.333555 Homo sapiens clone 24859 mRNA sequence 2.41 2.88

445982 BE410233 Hε.13501 pescadillo (zebrafish) homolog 1, contai 1.60 1.35

446078 AI339982 Hs.156061 ESTs 1.00 42.00

446102 AW168067 Hs.317694 ESTs 1.00 1.00

446157 BE270828 Hs.131740 Homo sapiens cDNA: FLJ22562 fis, clone H 1.70 1.63

446269 AW263155 Hs.14559 hypothetical protein FLJ10540 73.01 48.00

446292 AF081497 Hs.279682 Rh type C glycoprotein 1.55 1.26

446293 AI420213 Hs.149722 ESTs 1.00 2.00

446423 AW139655 Hs.150120 ESTs 1.10 4.19

446428 AW082270 Hs.12496 ESTs, Weakly similar to ALU4_HUMAN ALU S 0.53 3.26

446432 AI377320 Hs.150058 ESTs 1.00 5.00

446528 AU076640 Hs.15243 nucleolar protein 1 (120kD) 1.36 1.31

446574 AI310135 Hs.335933 ESTs 3.89 72.00

446619 AU076643 Hs.313 secreted phosphoprotein 1 (osteopontiπ, 32.03 20.23

446636 AC002563 Hs.15767 citron (rho-interacting, serine/threonin 4.19 5.07

446783 AW138343 Hs.141867 ESTs 2.82 9.47

446839 BE091926 Hs.16244 mitotic spindle coiled-coil related prat 110.28 28.00

446849 AU076617 Hs.16251 cleavage and polyadenylation specific fa 3.26 2.94

446856 AI814373 Hs.164175 ESTs 6.38 11.30

446872 X97058 Hs.16362 pyrimidinergic receptor P2Y, G-protβiπ c 1.98 2.03

446880 A1811807 Hs.108646 Homo sapiens cDNA FLJ14934 fis, clone PL 94.90 113.00

446921 AB012113 Hs.16530 small inducible cytokine subfamily A (Cy 1.67 3.90

446989 AK001898 Hs.16740 hypothetical protein FLJ11036 2.82 3.12

447022 AW291223 Hs.157573 ESTs 1.00 170.00

447033 AI357412 Hs.157601 ESTs 7.15 107.00

447078 AW885727 Hs.9914 ESTs 47.24 24.00

447081 Y13896 Hs.17287 potassium inwardly-rectifying channel, s 0.12 17.88

447131 NM 004585 Hs.17466 retinoic acid receptor responder (tazaro 0.97 1.48

447149 BE299857 Hs.326 TAR (HIV) RNA-blndiπg protein 2 1.24 1.26

447153 AA805202 Hs.315562 ESTs 1.00 54.00

447164 AF026941 Hs.17518 Homo sapiens cig5 mRNA, partial sequence 1.00 67.00

447178 AW594641 Hs.192417 ESTs 3.42 50.00

447250 AI878909 Hs.17883 protein phosphatase 1G (formerly 2C), ma 1.60 1.52

447289 AW247017 Hs,36978 melanoma antigen, family A, 3 1.00 1.00

447342 AI199268 Hs.19322 Homo sapiens, Similar to RIKEN cDNA 2010 28.63 1.00

447343 AA256641 Hs.236894 ESTs, Highly similar to S02392 alpha-2-m 146,62 51.00

447350 AI375572 Hs.172634 ESTs 1.00 12.00

447377 N27687 Hs.334334 transcription factor AP-2 alpha (activat 2.55 63.00

447415 AW937335 Hs.28149 ESTs, Weakly similar to KF3B_HUMAN KINES 0.91 1.13

447425 AI963747 Hs.18573 acylphosphatase 1, erythrocyte (common) 1.00 35.00

447519 U46258 Hs.339665 ESTs 59.89 49.00

447532 AK000614 Hs.18791 hypothetical protein FLJ20607 1.23 1.63

447534 AA401369 Hs.190721 ESTs 1.00 17.00

447636 Y10043 high-mobility group (noπhistone chromoso 1.41 1.11

447688 N87079 Hs.19236 Target CAT 1.00 39.00

447733 AF157482 Hs.19400 MAD2 (mitotic arrest deficient, yeast, h 1.17 1.12

447769 AW873704 Hs.320831 Homo sapienε cDNA FLJ14597 fis, clone NT 6.47 5.95

447802 AW593432 Hs.161455 ESTs 0.73 2.34

447850 AB018298 Hs.19822 SEC24 (S. cerevisiae) related gene famil 86.45 116.00

447924 AI817226 Hs.313413 ESTε, Weakly similar to T23110 hypotheti 1.00 1.00

447973 AB011169 Hs.20141 similar to S. cerevisiae SSM4 3.50 4.27

448030 N3Q714 Hs.325960 membrane-spanning 4-domains, subfamily A 4.13 142.00

448105 AI538613 Hs.298241 Transmembrane protease, serine 3 1.15 2.24

448243 AW369771 Hs.52620 integrin, beta 8 15.84 1.00

448278 W07369 Hs.11782 ESTs 0.97 1.90

448290 AK002107 Hs.20843 Homo sapiens cDNA FLJ 11245 fis, clone PL 1.00 1.00

448296 BE622756 Hs.10949 Homo sapiens cDNA FLJ14162 fis, clone NT 2.42 2.17

448357 BE274396 Hs.108923 RAB38, member RAS oncogene family 1.44 1.08

448390 AL035414 Hs.21068 hypothetical protein 1.00 43.00

448469 AW504732 Hs.21275 hypothetical protein FLJ11011 2.63 2.49

448569 BE382657 Hs.21486 signal transducer and activator of trans 1.84 2.53

448663 BE614599 Hs.106823 hypothetical protein MGC14797 3.29 46.00

448672 AI955511 Hs.225106 ESTs 1.00 21.00

448733 NM 05629 Hε.187958 solute carrier family 6 (πeurolransmitte 1.82 1.08

448741 BE614567 Hs.19574 hypothetical protein MGC5469 2.48 1.92

448757 AI366784 Hs.48820 TATA box binding protein (TBP)-associate 23.53 20.00

448775 AB025237 Hs.388 nudix (nucleoside diphosphate linked oi 2.34 1.97

448826 AI580252 Hs.293246 ESTs, Weakly similar to putative p150 [H 74.07 62.67

448830 AL031658 Hs.22181 hypothetical protein dJ310O13.3 1.37 1.31

448844 AI581519 Hs.177164 ESTs 1.00 31.00

448988 Y09763 Hs.22785 gamma-aminobutyric acid (GABA) A recepto 1.84 1.95

448993 AI471630 KIAA0144 gene product 1.63 1.49

449003 X76342 Hs.389 alcohol dehydrogenase 7 (class IV), mu o 1.00 1.00

449029 N28989 Hs.22891 solute carrier family 7 (cationic amino 1.97 2.26

449040 AF040704 Hs.149443 putative tumor suppressor 0.97 1.56

449048 Z45051 Hs.22920 similar to S68401 (cattle) glucose indue 27.13 90.00

449053 AI625777 Hs.344766 ESTs 8.33 44.00

449054 AF148848 Hs.22934 myoneurin 73.85 104.00

449101 AA205847 Hs.23016 G protein-coupled receptor 2.58 27.00 449167 T05095 Hs 19597 KIAA1694 protein 1 61 236

449207 AL044222 Hs 23255 nucleoponn 155kD 236 156

449228 AJ403107 Hs 148590 protem related with psonasiε 1 15 1 15

449230 BE613348 Hs 211579 melanoma cell adhesion molecule 20665 151 00

449305 AI638293 gb tt09b07 x1 NCI_CGAP_GC6 Homo sapiens 1728 4500

449318 AW236021 Hs 78531 Homo sapiens, Similar to RIKEN cDNA 5730 2639 3500

449448 D60730 Hs 57471 ESTs 100 1 00

449467 AW205006 Hs 197042 ESTs 1 00 1 00

449523 NM 000579 Hs 54443 chemokine (C-C motif) receptor 5 5680 21686

449722 BE280074 Hs 23960 cyclm B1 15003 100

449976 H06350 Hs 135056 Human DNA sequence from clone RP5-850E9 216 285

450001 NM 001044 Hs406 solute carrier family 6 (neurotransmitte 1 17 145

450098 W27249 Hs8109 hypothetical protein FLJ21080 179 238

450101 AV649989 Hs 24385 Human hbc647 mRNA sequence 100 6900

450149 AW969781 Hs 132863 Zic family member 2 (odd paired Drosophi 1 00 1 00

450193 AI916071 Hs 15607 Homo sapiens Fancom anemia complementat 2985 3400

450221 AA328102 Hs 24641 cytoskeleton associated protein 2 1 00 1 00

450372 BE218107 Hs 202436 ESTs 100 1 00

450375 AA009647 Hs 8850 a disintegrin and metalloproteinase doma 51 26 9300

450447 AF212223 Hs 25010 hypothetical protein P15-2 12320 181 00

450568 AL050078 Hs 25159 Homo sapiens cDNA FLJ 10784 fis, clone NT 100 1900

450589 AI701505 Hs 202526 ESTs 100 2300

450684 AA872605 Hs 25333 interleukin 1 receptor, type II 100 10000

450701 H39960 Hs 288467 Homo sapiens cD A FLJ 12280 fis, clone MA 189 155

450705 U90304 Hs 25351 iroquois ho eobox protein 2A (IRX-2A) ( 100 4500

450832 AA401369 Hs 190721 ESTs 2517 1700

450937 R49131 Hs 26267 ATP-dependant interferon response protei 9092 9000

450983 AA305384 Hs 25740 EROI (S cβrevιsιae)-lιke 333 1 70

451105 AI761324 gb ι60b11 x1 NCI_CGAP_Co16 Homo sapiens 1502 12400

451110 AI955040 Hs 265398 ESTs, Weakly similar to transformation r 1 00 14300

451253 H48299 Hs 26126 claudin 10 302 229

451291 R39288 Hs 6702 ESTs 1 00 1 00

451320 AW498974 diacylglycerol kinase, zeta (104kD) 292 1800

451380 H09280 Hs 13234 ESTs 690 667

451386 AB029006 Hs 26334 spastic paraplegia 4 (autoso al dominant 3575 7200

451437 H24143 Hs 31946 hypothetical protein FLJ11071 100 6900

451462 AK000367 Hs 26434 hypothetical protein FLJ20360 1 83 210

451524 AK001466 Hs 26516 hypothetical protein F 10604 1 13 107

451541 BE279383 Hs 26557 plakophilm 3 1 88 1 33

451592 AI805416 Hs 213897 ESTs 1 00 100

451635 AA018899 Hs 127179 cryptic gene 1 52 1 92

451743 AA401369 Hs 190721 ESTs 495 1700

451806 NM_003729 Hs 27076 RNA 3'-termιnal phosphate cyclase 1355 31 00

451807 W52854 hypothetical protein FLJ23293 similar to 1 55 3500

451871 AI821005 Hs 118599 ESTs 1 81 253

451952 AL120173 Hs 301663 ESTs 100 2200

452012 AA307703 Hs 279766 kiπeslπ family member 4A 343 226

452046 AB018345 Hs 27657 KIAA0802 protein 5659 1900

452194 AI694413 Hs 332649 olfactory receptor, family 2, subfamily 1 67 409

452206 AW340281 Hs 33074 Homo sapiens clone IMAGE 3606519, mRNA, 931 5300

452240 AA401369 Hs 190721 ESTs 1342 1700

452256 AK000933 Hs 28661 Homo sapiens cDNA FLJ10071 fis clone HE 3903 9400

452281 T93500 Hs 28792 Homo sapiens cD A FLJ 11041 fis, clone PL 15301 34000

452291 AF015592 Hs 28853 CDC7 (cell division cycle 7, S cerevisi 1 95 2300

452295 BE379936 Hs 28866 programmed cell death 10 4233 61 00

452304 AA025386 Hs 61311 ESTs, Weakly similar to S 10590 cysteine 1 17 214

452340 NM 002202 Hs 5Q5 ISL1 transcπption factor, UM/homeodoma 100 1300

452349 AB028944 Hs 29189 ATPase, Class VI, type 11A 1 09 1 42

452367 U71207 Hs 29279 eyes absent (Drosophila) homolog 2 5449 5300

452401 NM_007115 Hs 29352 tumor necrosis factor, alpha-induced pro 100 3200

452410 AL133619 Homo sapiens mRNA, cDNA DKFZp434E2321 (f 1 26 1 99

452461 N78223 Hs 108106 transcnptjon factor 2447 3500

452571 W31518 Hs 34665 ESTs 5461 10200

452613 AA461599 Hs 23459 ESTs 139 132

452699 AW295390 Hs 213062 ESTs 100 2600

452705 H49805 Hs 246005 ESTs 100 100

452747 AF160477 Hs 61460 Ig suparfamily receptor LNIR 11287 1 29

452787 AW294022 Hs 222707 KIAA1718 protein 100 100

452795 AW392555 Hs 18878 hypothetical protein FLJ21620 1 00 100

452823 AB012124 Hs 30696 transcπption factor-like 5 (basic helix 791 7500

452833 BE559681 Hs 30736 KIAA0124 protein 316 192

452838 U65011 Hs 30743 preferentially expressed antigen in ela 17435 100

452862 AA401369 Hs 190721 ESTs 9826 1700

452865 AW173720 Hs 345805 ESTs, Weakly similar to A47582 B-cell gr 1 55 100

452934 AA581322 Hs4213 hypothetical protein MGC16207 173 1 19

452946 X95425 Hs 31092 EphA5 100 100

452976 R44214 Hs 101189 ESTs 1 58 1 98

453028 AB0Q6532 Hs 31442 RecQ protein-like 4 1 80 160

453095 AW295660 Hs 252756 ESTs 077 1 50

453102 NM 007197 Hs 31664 frizzled (Drosophila) homolog 10 100 1 00

453103 AI301052 Hs 153444 ESTs 100 100

453120 AA292891 Hs 31773 pregnancy-induced growth inhibitor 1 23 120

453153 N53893 Hs 24360 ESTs 100 8300

453160 AI263307 Hs 239884 H2B histone family, member L 100 3000

453197 AI916269 Hs 109057 ESTs, Weakly similar to ALU5_HUMAN ALU S 100 13400 453210 AL133161 Hs.32360 hypothetical protein FLJ10867 1.69 1.93

453240 AI969564 Hs.166254 hypothetical protein DKFZp566l133 1.00 1.00

453317 NM 002277 Hs.41696 keratin, hair, acidic, 1 1.19 1.27

453323 AF034102 Hs.32951 solute carrier family 29 (nucleoside tra 4.90 4.11

453331 AI240665 Hs.8850 ESTs 199.42 340.00

453392 U23752 Hs.32964 SRY (sex determining region Y)-box 11 1.00 16.00

453431 AF094754 Hs.32973 glycine receptor, beta 1.00 1.00

453439 AI572438 Hs.32976 guanine nucleotide binding protein 4 3.44 5.17

453459 BE047032 Hs.257789 ESTs 2.84 5.58

453563 AW608906.cαmp Hs.181163 hypothetical protein MG 4.58 90.00

453633 AA357001 Hs.34045 hypothetical protein FLJ20764 1.74 1.60

453775 NM 002916 Hs.35120 replication factor C (activator 1) 4 (37 19.49 1.00

453830 AA534296 Hs.20953 ESTs 24.92 25.00

453857 AL080235 Hs.36861 DKFZP586E1621 protein 167.59 66.00

453867 AI929383 Hε.33032 hypothetical protein DKFZp434N185 1.00 39.00

453883 AI638516 Hs.347524 cofactor required forSpl transcriptioπa 1.97 1.58

453884 AA355925 Hs.36232 KIAA0186 gene product 63.89 20.00

453900 AW003582 Hs.226414 ESTs, Weakly similar to ALU8.HUMAN ALU S 20.41 16.00

453922 AF053306 Hs.36708 budding uninhibited by benzi idazoles 1 7.09 22.00

453941 U39817 Hs.36820 Bloom syndrome 29.75 19.00

453964 AI961486 Hs.12744 ESTs 1.00 1.00

453968 AA847843 Hs.62711 Homo sapiens, clone IMAGE:3351295, mRNA 2.06 1.81

453976 BE463830 Hs.163714 ESTs 3.02 131.00

454024 AA993527 Hs.293907 hypothetical protein FLJ23403 1.00 131.00

454034 NM 000691 Hs.575 aldehyde dehydrogenase 3 family, member 1.23 1.02

454042 T19228 Hs.172572 hypothetical protein FLJ20093 30.63 171.00

454059 NM 003154 Hs.37048 statherin 1.00 1.00

454066 X00356 Hs.37058 calcitonin/calcitonin-related polypeptid 1.01 1.45

454098 W27953 Hs.292911 ESTs, Highly similar to S60712 band-6-pr 1.26 1.11

454241 BE144666 gb:C 2-HT0176-041099-017-c02 HT0176 Homo 6.33 5.04

454417 AI244459 Hs.110826 trinucleotide repeat containing 9 4.30 7.82

454439 AW819152 Hs.154320 DKFZP56601646 protein 1.00 1.00

455175 AW993247 gb:RC2-BN0033-180200-014-h09 BN0033 Homo 13.75 103.00

455601 AI368680 Hs.816 SRY (sex determining region Y)-box 2 206.11 1.00

456237 AA203682 gb:zx52e07.r1 SoaresJetal_liver_spleen_ 1.00 1.00

456321 NM 001327 Hs.87225 cancer/testis antigen 1.14 1.10

456475 NM_000144 Hs.95998 Friedreich ataxia 1.00 48.00

456508 AA502764 Hs.123469 ESTs, Weakly similar to AF208855 1 BM-01 162.25 189.00

456534 X91195 Hs.100623 phospholipase C, beta 3, neighbor pseudo 2.12 1.80

456736 AW248217 Hs.1619 achaete-scute complex (Drosophila) homol 1.15 1.94

456759 BE259150 Hs.127792 delta (Drosophila)-like 3 1.00 1.00

456990 NM 004504 Hs.171545 HIV-1 Rev binding protein 16.42 84.00

457200 U33749 Hs.197764 thyroid transcription factor 1 0.57 1.76

457234 AW968360 Hs.14355 Homo sapiens cDNA FLJ13207 fis, clone NT 2.71 4.15

457465 AW301344 Hs.122908 DNA replication factor 46.37 47.00

457489 AI693815 Hs.127179 cryptic gene 1.12 1.35

457646 AA725650 Hs.112948 ESTs 1.55 2.51

457733 AW974812 Hs.291971 ESTs 1.00 55.00

457819 AA057484 Hs.35406 ESTs, Highly similar to unnamed protein 4.36 3.18

458092 BE545684 Hs.343566 KIAA0251 protein 1.00 1.32

458098 BE550224 metallothionein 1E (functional) 1.00 22.00

458207 T28472 Hs.7655 U2 small nuclear ribonucleoprotein auxil 2.06 1.88

458242 BE299588 Hs.28465 Homo sapiens cDNA: FLJ21869 fis, clone H 1.00 1.00

458247 R14439 Hs.209194 ESTs 7.00 9.85

458679 AW975460 Hs.142913 ESTs 1.00 3.00

458778 AW451034 Hs.326525 arylsulfatase D 1.31 2.01

458933 AI638429 Hs.24763 RAN binding protein 1 1.98 1.71

459352 AW810383 Hs.206828 ESTs 12.60 63.00

459670 F01020 Hs.172004 fitin 1.00 1.00

459702 AI204995 gb:an03c03.x1 Stratagene schizo brain S1 1.00 237.00

TABLE 9B Pkey: Unique Eos probeset identifier number

CAT number: Gene cluster number Accession: Genbank accession numbers

Pkey CAT Number Accession

407746 10125.1 AK001962 R69415 BE464605 AA418699 AA053293 AA149075 AA058396 AW338226 AW272659 AA454607 AI139535 AW469852 AI275461

AW271982 AA730033 AA576507 AA991217 AA782067 AI985851 AA805864 AA505598 AW469857 R69546 AA988279 AW001647 N63320

D82661 T27343 AA306950 AA360989 R58778

408070 1036688 1 AW148852BE350895

408660 107294 1 AA525775 AA056342 AI538978 AW975281 AA664986

409522 113735 1 AA075382AA075431

409866 1156522 J AW502152 H41202H29772

410032 1170435 1 BE065985 BE065944 BE066008 BE066083 BE066093

411089 123172.1 AA456454 AA713730 AA091294 AA584921 N86077 AW836781 AA601031 AA579876 AA551106 AA633168 AW905577 AI955808 AI679386

AI679895 AA514764 AA454562 AI082382 AA595822 AA551351 AA586369 AA666384 AA188934 AA666398 AA551297 AA565188

411152 1234028J BE069199 AW936012 AW877466 AW819782 AW935798 AW835546 AW936042 BE069121 AW835625 AW877536 AW935885 BE069202

AW820019 AW935937 BE160180 AW935946 BE069101 BE069125 AW877527 BE160316 BE160398 AW935794 AW835701 AW935784 412537 1304.1 AL031778 X59711 NM 02505 M59079 AI870439 AI494259 AW664010 AA405063 AA436132 BE174516 AA412691 AI400314 AA436024

T29403 BE079412 BE079428 N90322 A1631202 AI141758 AI016793 AH67566 AI862075 A1375230 AI208445 AW235763 AL044113 AA382556

AW953918 AA927051 AA889823 BE003094 AW390155 AW360805 AW360823 AW360810 AA425472 AI694282 AL044114 AI684577 AI809865 AI478773 AI160445 AI674630 N69088 AW665529 N49278 AI129239 AI457890 AI621264 AW297152 AI268215 AA907787 AI286170 AI017982

AI963541 AI469807 AI969353 BE552356 N66509 AA736741 AA382555 AW075811 AW292026

412811 132943.1 H06382 AW957730 AA352014 R13591 AA121201 D60420 BE263253 BE047862 Z41952 A1424991 AI693507 A1863108 AA599060 A1091148

AA598689 R39887 AA813462 AW016452 H06383 R41807 AI364268 AA620528 AI241940 AW089149 AW090733 AW088875 Z38240

AA121202 R17734

413690 1383256.1 BE157489 BE157560 414883 15024.1 AA926960 AA926959 W76521 W24270 W21526 AA037172 BE267636 H83186 AA469909 N86396 AA001348 BE535736 AA081745 BE566245

AA082436 H72525 H77575 N49786 W80565 H78746 BE569085 W04339 R98127 T55938 BE279271 AW960304 T29812 AA476873 BE297387

AA292753 AA177048 NM 001826 X54941 BE314366 AA908783 AI719075 BE270172 BE269819 AA889955 AI204630 W25243 AI935150

AA872039 W72395 T99630 AI422691 H98460 N31428 BE255916 H03265 AI857576 AA776920 AA910644 AA459522 AA293140 AW514667

R75953 AW662396 AA662522 AI865147 AI423153 AW262230 AA584410 AA583187 AW024595 AW069734 AI828996 AA282997 AA876046

AW613002 AA527373 AW972459 AI831360 AA621337 AA100926 AA772418 AA594628 AI033892 W95096 AI034317 AA398727 AI085031

N95210 AI459432 AI041437 AA932124 AA627684 AA935829 AI004827 AI423513 AI094597 H42079 R54703 A1630359 AA617681 AA978045

AA643280 44561 A1991988 A1537692 AI090262 AA740817 AI312104 AI911822 AA416871 AI185409 AA129784 AA701623 AI075239

AI139549 AA633648 AI339996 AI336880 AA399239 AI078708 AI085351 AI362835 AI346618 AH 46955 AI989380 AI348243 N92892 AA765850

AI494230 AI278887 AA962596 AI492600 W80435 AA001979 R97424 AI129015 N24127 AA157451 AA235549 AA459292 AA037114 AA129785

AI494211 AW059601 AW886710 R92790 N59755 AI361128 AW589407 H47725 H97534 H48076 H48450 T99631 AW300758 H03431 R76789

AA954344 H77576 R96823 AI457100 N92845 N49682 H42038 BE220698 BE220715 H99552 AA701624 N74173 R54704 H79520 H72923

H03266 BE261919 AA769633 AA480310 AA507454 AA910586 AI203723 AW104725 W25611 W25071 T88980 H03513 T77589 R99156

W95095 R97470 AA702275 T77551 AA911952 H82956 N83673 AA283672

415989 156454.1 AI267700 AI720344 AA191424 AI023543 AI469633 AA172056 AW958465 AA172236 AW953397 AA355086 417324 166714.1 AW265494 AA455904 AA195677 AW265432 AW991605 AA456370 418574 17690.1 N28754 N28747 AI568146 AI979339 AA322671 AA322672 AW955043 AI990326 AA776406 AI016250 AA843678 AW451882 N23137 N23129

W70051 AI038748 AA831327 AI925845 AW945895

418712 1784125.1 Z42183T31621 T97478 419443 184788.1 D62703AA242966 D79798 419502 18535.1 AU076704 T74854 T74860 T72098 T73265 T73873 T69180 T74658 T58786 T60385 T73410 T68781 T67845 T67593 T73952 T67864 T60630

T68367 T68401 T53959 T72360 T72099 T60377 T58961 T71712 T72821 T64738 T74645 T72037 T68688 T72063 T73258 T72826 T64242

T68220 T74673 T71800 T68355 T61227 T62738 T69317 T53850 T64692 T73768 T73962 T73382 T68914 T70975 T73400 T60631 T73277

T73203 T70498 T61409 T58925 NM_000508 M64982 T68301 T73729 T69445 T60424 T67922 T67736 T68716 T67755 T74765 T73819 T58719

T74756 T60477 T74863 T61109 T68329 T58850 T71857 T73425 T53736 T68607 T58898 T64309 T72031 T72079 T64305 T71908 T68107

T71916 T73787T56035 T64425T71870 T60476 T61376T67820 T71895 T41006 T69441 T68170 T74617 T71958 T69440 T61875 R06796

H48353 T71914 T53939 T64121 AA693996 T72525 T67779 T68078 AA011465 AA345378 AV654847 AV654272 AV656001 AI064740 T82897

N33594 AA344542 AW805054 AI207457 T61743 AA026737 H94389 AA382695 AA918409 T68044 S82092 T39959 AI017721 AA312395

AA312919 T40156 H66239 AV652989 H38728 R98521 AV655200 R95790 W03250 W00913 AA344136 AV660126 R97923 AA343596

AW470774 AV651256 N54417 AA812862 AW182929 AH 11192 H61463 H72060 AA344503 H38639 AI277511 AV661108 AI207625 T47810

AA235252 T27853 T47778 R95746 H70620 AA701463 AW827166 R98475 C20925 AV657287T71959 T71313 T73920 T73333 T61618 T69293

T69283 T73931 T72178 T72456 AV645639 AV653476 T72957 T72300 T58906 T71457 T70494 T72956 T70495 T68267 T74407 T85778

AA344726 T27854 T74485 T74101 T73868 T71518 T72304 AA343853 T73909 T68070 T72065 H72149 T73493 T73495 AV645993 R02293

T70475 T64751 AA344441 AA343657 AA345732 AA344328 Al 110639 AA344603 AF063513 T64696 T68516 T72223 T60507 T67633 R29500

T72517 R02292 T60599 T69206 T70452 T74677 R29366 T61277 T74914 T60352 R29675 T74843 AV645792 AA344408 T69197 T72057

T69368 T69358 T68258 AV650429 T73341 T61702 T74598 T40095 K02272 T40106 AA343045 AA341908 AA341907 AA342807 AA341964

T53747 T72042 T62764 AI064899 AA343060 T67832 T72440 T71770 T68091 T69108 T72449 T69167 T71289 T68251 AV654844 T64375

AA345234 T67598 AA011414 T68036 H48262 AI207557 T68219 W86031 T69081 T64232 R93196 T62136 AV650539 H67459 T72978

AA3445B3 T60362 H58121 T95711 T72803 T68055 T71715 R29036 T72793 T69122 T64595 T62888 T69139 T68291 T64652 T67971 T46862

AA693592 AI248502 R29454 T64764 T57001 T73052 T71429 T51176 T58866 AV655414 H90426 AA342489 T73666 T67848 T72512 T53835

T67837 T73317 T74273 T69420 T68245 T74380 T67862 T74474 T56068

419936 1891811 AI792788 BE142230 AA252019

421582 2041.1 AI910275 X00474 X52003 X05030 NM_003225 AA314326 AA308400 AA506787 AA314825 AI571948 AA507595 AA614579 AA587613 R83818

AA568312AA614409AA307578AI925552AW950155AI910083M12075 BE074052AW004668AA578674AA582084BE074053BE074126

BE074140 AA514776 AA588034 BE074051 BE074068 AW009769 AW050690 AA858276 R55389 AI001051 AW050700 AW750216 AA614539

BE074045 AI307407 AW602303 BE073575 AI202532 AA524242 AI970839 AI909751 BE076078 AI909749 R55292

422128 211994.1 AW881145 AA490718 M85637 AA304575 T06067 AA331991

423034 224122_1 AL119930 AA320696 AW752565

423816 23234J AL031985 AL137241 AI792386 AI733664 AI857654 AI049911

424200 2365951 AA337221 AA336756AW966196

424999 2458351 AW953120 R56325AA349562

426966 2738961 AI493134 AI498691 AW771508 AI498457 AI768408 AI783624 AI383985 AI580267 D79813 AA393768

426991 274151 AK001536 AA191092 AW510354 AI554256 AL353968 AA134266

427260 2765981 AA663848 AA400100 AA401424

428023 285892 AL038843 AA161338 BE268213 AA425597 N87306 AA092969 BE566038 AA247451 N47392 AI928802 AW182584 AW027872 AI819831

AI936994 W56258 AI653448 AI278611 AI283557 AI824306 AW338658 AW150899 AA687514 N47393 N29885 AA973469 A1O38904 AI292064

AI034339 AW674593 N72156 AI079733 AI038683 AI291616 AA491599 AA993675 AA837380 BE006554 BE006473 AI087090 T33044

AA652043 AI203503 AA583959 W35283 AI129926 Z41844 AW020925 AW575848 AI684603 AA493297 AI140689 AI277175 AA425444

AI932767 W02632 BE396786 R37261

429220 301384 AW207206 AW341473 AA448195 AI951341 429978 31150.1 AA249027 AL038984 AK001993 AL080066 AV652725 BE566226 AA345557 AA315222 AA090585 AA375688 AA301092 AA298454 W05762

AW607939 H51658 D83880 N84323 BE296821 AW947007 D61461 AW079261 AA329482 AW901780 AI354442 AA772275 R31663 A1354441

AI767525 H92431 AI916735 H93575 AI394255 AW014741 AI573090 C06195 AW612857 AW265195 AI339558 AI377532 AI308821 AI919424

AI589705 AW055215 AI336532 AI338051 AA806547 C75509 C00618 AW071172 AW769904 AA630381 AI678018 AI863985 D79662 BE221049

AW265018 AI589700 AW196655 N76573 AI370908 BE042393 N75017 AI698870 AW960115

430439 318081 AL133561 AL041090 AL117481 AL122069 AW439292 AI968826 430935 325772.1 AW072916 Al 184913 AA489195 AW466994 AW469044 N59350 AI819642 AI280239 AI220572 AA789302 AI473611 AW841126 D60937 431089 3278251 BE041395AA491826AA621946M715980AA666102 431322 3315431 AW970622 AA503009 AA502998 AA502989 AA502805 T92188 432407 34624.1 AA221036 R87170 BE537068 BE544757 C18935 AW812058 T92565 AA227415 AA233942 AA223237 AA668403 AA601627 AW869639

BE061833 BE000620 AW961170 AW847519 AA308542 AW821833 AW945688 C04699 AA205504 AA377241 AW821667 AA055720

AW817981 AW856468AA155719AA179928T03007AW754298AA227407AA113928AA307904 C16859

434414 38585 AI798376 S46400AW811617AW811616 W00557BE142245AW858232AW861851 AW858362AA232351 AA218567AA055556A 858231

AW857541 AW814172H66214AW814398AF134164AA243093AA173345AA199942AA223384AA227092AA227080T12379AA092174

T61139AA149776AA699829AW879188AW813567AW813538AI267168AA157718AA157719 AA100472AA100774AA130756AA157705

AA157730 AA157715 AA053524 AW849581 AW854566 C05254 AW882836 T92637 AW812621 AA206583 AA209204 BE156909 AA226824

AI829309 AW991957 N66951 AA527374 H66215 AA045564 AI694265 H60808 AA149726 AW195620 BE081333 BE073424 AW817662

AW817705 AW817703 AW817659 BE081531 H59570

436608 42361_3 AA628980 AM266038E504035 438091 44964 1 AW373062T55662 A1299190 BE174210 A 579001 H01811 W40186 R67100 AI923886 A 952164 AA628440 AW898607 A 898616

AA709126 AW898628 AW898544 AA947932 AW898625 AW898622 AI276125 AH 85720 AW510698 AA987230 T52522 BE467708 AW243400 AW043642 AI288245 AH 86932 D52654 D55017 D52715 D52477 D53933 D54679 AI298739 AH 46984 AI922204 N98343 BE174213 AA845571 AI813854 A1214518 AI635262 AI139455 AI707807 AI698085 AW884528 AI024768 AI004723 AW087420 AI565133 N94964 AI268939 5 AW513280 AI061126 AI435818 AI859106 AI360506 AI024767 AA513019 AA757598 X56196 AA902959 AI334784 AI860794 AA010207

AW890091 AW513771 AI951391 AI337671 T52499 AA890205 AI640908 H75966 AA463487 AA358688 AI961767 AI866295 AA780994 AI985913 BE174196 AA029094 AW592159 T55581 N79072 AI611201 AA910812 AI220713 AW149306 AI758412 AA045713 R79750 N76096 439000 467716.1 AW979121 AA847986 AA829098

439285 47065.1 AL133916 N79113 AF086101 N76721 AW950828 AA364013 AW955684 AI346341 AI867454 N54784 AI655270 AI421279 A 014882

10 AA775552 N62351 N59253 AA626243 AI341407 BE175639 AA456968 AI358918 AA457077

439780 47673.1 AL109688 23665 26578

441128 51021.2 AA570256 AW014761 AA573721 AI473237 AI022165 AA554071 AA127551 N90525 AW973623 AA447991 AA243852 BE328850 AI148171

A1359627 AI005068 AI356567 AA232991 AW016855AA906902AA233101 AA127550 BE512923 443068 558874.1 A!188710 AI032142 AW078833 N30308 AW675632 AI21902B A1341201 N22181 H95390

15 443947 586160.1 W24187 W24194 R17789

447636 7301.1 Y10043 NM.005342 L05085 AL034450 BE614226 AW749053 AA379173 AA248230 BE514634 AA334622 R70656 AA367593 AA214649

AA369318 AW957081 R05760 AA039903 AI886597 AW630122 AA906264 AA041527 R01145 AI088688 BE463637 AA398795 AI354883 AI768938 AI569996 AI452952 AI168582 AI189869 AI086670 AW262560 AW613854 AA862839 AA435840 AA670197 AI024032 AI990659 AI990089 N81095 AA847919 AW960150 AA211075 AA044704 AA367594 AW582587 AW858854 AW818630 AW818281 AW818433 AW582595 20 AA096002 83992

448993 79225 1 AI471630 BE540637 BE265481 AW407710 BE513882 BE546739 AA053597 BE140503 BE218514 AW956702 AI656234 AI636283 AI567265

AW340858 BE207794 AA053085 R69173 AA292343 AA454908 AA293504 AI659741 AI927478 AA399460 AI760441 AA346416 BE047245 AA730380 AA394063 AA454833 AI982791 AI567270 AI813332 AI767858 AA427705 D20284 AI221458 BE048537 AI263048 AA346417 AA911497 BE537702 25 449305 804424.1 AI638293 AW813561

451105 859083.1 A1761324 AW880941 AW880937

451320^' 86576 1 AW118072 AI631982 T15734 AA224195 AI701458 W20198 F26326 AA890570 N90552 AW071907 AI671352 AI375892 T03517 R88265

AI124088 AA224388 AI084316 AI354686 T33652 AI140719 AI720211 T03490 AI372637 T15415 AW205836 AA630384 T03515 T33230 „ . AA017131 AA443303 T33623 AI222556 T33511 T33785 AI419606 D55612

30 451807 8865 1 W52854 AL117600 BE208116 BE208432 BE206239 BE082291 AW953423 AA351619 BE180648 BE140560 W60080 AA865478 N90291

AW450652 AW449519 AA993634 AI806539 AA351618 AW449522 AI827626 AA904788 AA380381 AA886045 AA774409 BE003229 Z41756 452410 9163.1 AL133619 AA468118 AA383064 AI476447 T09430 AI673758 AA524895 AI581345 AI300820 AW498812 AA256162 AI559724 AI685732

AA602400 AA905453 AI204595 AW166541 AA157456 AA156269 AA383652 AA431072 AW592707 AI435410 AW272464 AI215594 AA622747 R74039 N35031 AI804128 AW513621 AA868351 AI026826 AI493388 AA614641 W81604 AI567080 AI214351 AA730140 AI125754 AI200813 35 AI269603 AI565082 AI807095 AI476629 AA505909 AI368449 AI686077 AI582930 AW085038 AA757863 AA730154 AI767072 AA468316

AI734130 AI734138 AA426284 AA433997 AI741241 AW043563 AI732741 AI732734 AA437369 AA425820 AA664048 R74130 454241 1067807.1 BE144666 BE184942 AW238414 BE184946

455175 1257335.1 AW993247AW861464

456237 168730 1 AA203682 R11958

40 458098 47395.1 BE550224 AA832519 N45402 AW885857 N29245 BE465409 W07677 AW970089 AI299731 AA482971 BE503548 H18151 W79223 AF086393

AA461301 W74510 R34182 AI090689 N46003 BE071550 R28075 AW134982 AI240204 AI138906 AW026179 AI572316 BE466182 AI206395 AI276154A1273269AI422817AI371014AI421274AI188525AA939164 BE549810AW137865AI694996 BE503841 AA459718 BE327407 BE467534 BE218421 BE467767 AA989054 BE467063 AI797130 BE327781

45

TABLE 9C

Pkey: Unique number corresponding to an Eos probeset

Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. "Dunham I. et al." refers to the publication entitled "The DNA

5 O sequence of human chro oεome 22." Dunham I. et at, Nature (1999) 402:489-495.

Strand: Indicates DNA strand from which exons were predicted.

NLpositioπ: Indicates nucleotide positions of predicted exons.

Pkey Ref Strand NLposition

55 400512 9796593 Minus 1439-1615

400517 9796686 Minus 49996-50346

400560 9843598 Plus 94182-94323,97056-97243,101095-101236,102824-103005

400664 8118496 Plus 13558-13721,13942-14090,14554-14679

400665 8118496 Plus 16879-17023

60 400666 8118496 Plus 17982-18115,20297-20456

400749 7331445 Minus 9162-9293

400763 8131616 Minus 35537-35784

401027 7230983 Minus 70407-70554,71060-71160

401093 8516137 Minus 22335-23166 5 401203 9743387 Minus 172961-173056,173868-173928

401212 9858408 Plus 87839-88028

401411 7799787 Minus 144144-144329

401435 8217934 Minus 54508-55233

401464 6682291 Minus 170688-170834 0 401714 6715702 Plus 96484-96681

401747 9789672 Minus 118596-118816,119119-119244,119609-119761,120422-120990,130161-130381,130468-130593,131097-131258,131866- 131932,132451-132575,133580-134011

401760 9929699 Plus 83126-83250,85320-85540,94719-95287

401780 7249190 Minus 28397-28617,28920-29045,29135-29296,29411-29567,29705-29787,30224-30573 5 401781 7249190 Minus 83215-83435,83531-83656,83740-83901,84237-84393,84955-85037,86290-86814

401785 7249190 Minus 165776-165996,166189-166314,166408-166569,167112-167268,167387-167469,168634-168942

401797 6730720 Plus 6973-7118

401961 4581193 Minus 124054-124209

401985 2580474 Plus 61542-61750 0 401994 4153858 Minus 42904-43124,43211-43336,4460744763,4519945281,4633746732

402075 8117407 Plus 121907-122035,122804-122921,124019-124161,124455-124610,125672-126076

402260 3399665 Minus 113765-113910,115653-115765,116808-116940

402265 3287673 Plus 21059-21168

402297 6598824 Plus 35279-35405,35573-35659 5 402408 9796239 Minus 110326-110491 402420 9796339 Plus 129750-129919

402674 8077108 Minus 39290-39502

402802 3287156 Minus 53242-53432

402994 2996643 Minus 4727-4969

403137 9211494 Minus 92349-92572,92958-93084,93579-93712,93949-94072,94591-94748,95214-95337

403306 8099945 Plus 127100-127251

403329 8516120 Plus 96450-96598

403381 9438267 Minus 26009-26178

403478 9958258 Plus 116458-116564

403485 9966528 Plus 2888-3001,3198-3532,36554117

403627 8569879 Minus 23868-24342

403715 7239669 Plus 85128-85292

404044 9558573 Minus 225757-225939

404076 9931752 Minus 3848-3967

404101 8076925 Minus 125742-125997

404140 9843520 Plus 37761-38147

404165 9926489 Minus 69025-69128

404185 4572584 Minus 129171-129327

404210 5006246 Plus 169926-170121

404253 9367202 Minus 55675-56055

404287 2326514 Plus 53134-53281

404298 9944263 Minus 73591-73723

404347 9838195 Plus 74493-74829

404440 7528051 Plus 80430-81581

404721 9856648 Minus 173763-174294

404794 4826439 Plus 101619-101898

404854 7143420 Plus 14260-14537

404877 1519284 Plus 1095-2107

404927 7342002 Plus 68690-69563

404996 6007890 Plus 37999-38145,38652-38998,39727-39872,4055740674,4235142450

405449 7622497 Plus 4223642570

405568 6006906 Plus 35912-36065

405572 3800891 Plus 85230-85938

405646 4914350 Plus 741-969

405676 4557087 Plus 73195-73917

405770 2735037 Plus 61057-62075

405932 7767812 Minus 123525-123713

406137 9166422 Minus 30487-31058

406360 9256107 Minus 7513-7673

406399 9256288 Minus 63448-63554

406467 9795551 Plus 182212-182958

TABLE 10A: Potential Therapeutic, Diagnostic and Prognostic targets for Therapy of Lung Cancer and Non-malignant Lung Disease

Table 2A shows about 307 genes up-regulated in non-malignant lung disease relative to lung tumors and normal body tissues and/or down-regulated in lung tumors relative to normal lung and non-malignant lung disease. These genes were selected from about 59660 probesets on the Eos/Affymetrix Hu03 Genechip array.

Table 10B show the accession numbers for those Pkey's lacking UnigenelD's for table 10A. For each probeset we have listed the gene cluster number from which the oligonucleotides were designed. Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs. These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California). The Genbank accession numbers for sequences comprising each cluster are listed in the "Accession" column,

Table 10C show the genomic positioning for those Pkey's lacking Unigene ID's and accession numbers in table 10A. For each predicted exon, we have listed the genomic sequence source used for prediction. Nucleotide locations of each predicted exon are also listed.

Pkey: ι Unique Eos probeset identifier number

ExAccn: Exemplar Accession number, Genbank accession number

UnigenelD: Unigene number

Unigene Title: Unigene gene title 1; Average of lung tumors (including squamous cell carcinomas, adenocarcinomas, small cell carcinomas, granulomatous and carcinoid tumors) divided by the average of normal lung samples

R2: Average of non-malignant lung disease samples (including bronchitis, emphysema, fibrosis, atelectasis, asthma) divided by the average of normal lung samples

Pkey ExAccn UnigenelD Unigene Title R1 R2

404394 ENSP00000241075:TRRAP PROTEIN. 0.79 3,10

404916 Target Exon 1.00 159.00

405257 Target Exon 1.00 422.00

407228 M25079 Hs.155376 hemoglobin, beta 0.47 2.33

407568 AA740964 Hs.62699 ESTs 1.00 123.00

408562 AI436323 Hs.31141 Homo sapiens mRNA for KIAA1568 protein, 1.00 230.00

409031 AA376836 Hs.76728 ESTs 1.00 128.00

410434 AF051152 Hs.63668 toll-like receptor 2 39.65 149.00

410467 AF102546 Hs.63931 dachshund (Drosophila) homolog 1.00 109.00

410808 T40326 Hs.167793 ESTs 1.14 13.14

412351 AL135960 Hs.73828 T-cell acute lympbocytic leukemia 1 0.37 2.27

412372 R65998 Hs.285243 hypothetical protein FU22029 1.00 173.00

413795 AL040178 Hs.142003 ESTs 0.10 11.90

414154 AW205314 Hs.323060 ESTs 0.62 2.09

414214 D49958 Hs.75819 glycoprotein M6A 0.03 4.55

414998 NM.002543 Hs.77729 oxidised low density lipoprotein (lectin 0.64 2.97

415122 D60708 Hs.22245 ESTs 0.07 8.97

415765 NM 05424 Hs.78824 tyrosine kinase with immunoglobulin and 0.67 1.65

415775 H00747 Hs.29792 ESTs, Weakly similar to I38022 hypotheti 0.29 2.64

415910 U20350 Hs.78913 chemokine (C-X3-C) receptor 1 1.00 145.00 416319 AI815601 Hs.79197 CD83 antigen (activated B lymphocytes, i 15.32 237.00

416402 NM 000715 Hs.1012 complement component 4-binding protein, 0.64 4.00

417355 D13168 Hs.82002 endothelin receptor type B 0.01 3.90

417421 AL138201 Hs.82120 nuclear receptor subfamily 4, group A, m 36.30 357.00

417511 AL049176 Hs.82223 chordin-like 1.00 179.00

418489 U76421 Hs.85302 adenosine deaminase, RNA-specific, B1 (h 0.02 6.00

418726 BE241812 Hs.87860 protein tyrosine phosphatase, non-recept 1.00 113.00

418741 H83265 Hs.8881 ESTs, Weakly similar to S41044 chromosom 0.44 1.90

418883 BE387036 Hs.1211 acid phosphatase 5, tartrate resistant 0.96 2.04

419086 NMJ00216 Hs.89591 Kallmann syndrome 1 sequence 0.62 2.74

419150 T29618 Hs.89640 TEK tyrosine kinase, endothelial (venous 0.03 6.90

419235 AW470411 Hs.288433 πeurotrimin 1.48 5.13

419407 AW410377 Hs.41502 hypothetical protein FLJ21276 37.55 336.00

420556 AA278300 Hs.124292 Homo sapiens cDNA: FLJ23123 fis, clone L 0.80 3.65

420656 AA279098 Hs.187636 ESTs 1.65 8.07

420729 AW964897 Hs.290825 ESTs 2.99 25.82

421177 AW070211 Hs.102415 Homo sapiens mRNA; cDNA DKFZp586N0121 (f 0.46 1.95

422060 R20893 Hs.325823 ESTs, Moderately similar to ALU5_HUMAN A 1.00 156.00

422426 W79117 Hs.58559 ESTs 0.03 7.44

422652 AW967969 Hs.118958 syntaxin 11 0.14 3.62

423099 NM 002837 Hs.123641 protein tyrosine phosphatase, receptor t 0.01 3.16

424433 H04607 Hs.9218 ESTs 0.75 141.75

424585 AA464840 Hs.131987 ESTs 1.00 167.00

424711 NM 05795 Hs.152175 calcitonin receptor-like 0.43 3.01

424973 X92521 Hs.154057 matrix metalloproteinase 19 0.37 19.45

425023 AW956889 Hs.154210 endothelial differentiation, sphingolipi 0.14 3.35

425664 AJ006276 Hs.159003 transient receptor potential channel 6 1.00 94.00

425998 AU076629 Hs.165950 fibroblast growth factor receptor 4 0.68 1.42

426657 NM 015865 Hs.171731 solute carrier family 14 (urea transport 0.03 3.74

426753 T89832 Hs.170278 ESTs 1.00 141.00

427558 D49493 Hs.2171 growth differentiation factor 10 1.00 117.00

427983 M17706 Hs.2233 colony stimulating factor 3 (granulocyte 0.75 2.20

428467 AK002121 Hs.184465 hypothetical protein FLJ 11259 0.76 2.25

428927 AA441837 Hs.90250 ESTs 0.01 3.62

429496 AA453800 Hs.192793 ESTs 1.00 138.00

430468 NM.004673 Hs.241519 angiopoietin-like 1 1.00 132.00

431385 BE178536 Hs.11090 membrane-spanning 4-domains, subfamily A 1.00 157.00

431728 NMJ07351 Hs.268107 multimerin 1.00 157.00

431848 AI378857 Hs.126758 ESTs, Highly similar to AF175283 1 zinc 0.34 2.24

432128 AA127221 Hs.117037 ESTs 0.00 1.15

432519 AI221311 Hs.130704 ESTs, Weakly similar to BCHUIA S-100 pro 0.01 2.06

433043 W57554 Hs.125019 lymphoid nuclear protein (LAF4) mRNA 1.00 267.00

433803 AI823593 Hs.27688 ESTs 1.00 105.00

434730 AA644669 Hs.193042 ESTs 1.05 3.15

435472 AW972330 Hs.283022 triggering receptor expressed on myeloid 0.83 1.94

436532 AA721522 gb:nv54h12.r1 NCI CGAP Ewl Homo sapiens 1.00 218.00

437119 AI379921 Hs.177043 ESTs 1.00 133.00

437140 AA312799 Hs.283689 activator of CREM in testis 0.67 122.67

437211 AA382207 Hs.5509 ecotropic viral integration site 2B 1.00 142.00

437960 AI669586 Hs.222194 ESTs 1.00 147.00

438202 AW169287 Hs.22588 ESTs 1.00 141.00

438873 AI302471 Hs.124292 Homo sapiens cDNA: FLJ23123 fis, clone L 0.71 3.66

438875 AA827640 Hs.189059 ESTs 23.32 370.00

441048 AA913488 Hs.192102 ESTs 0.77 8.50

441188 AW292830 Hs.255609 ESTs 3.43 16.36

441499 AW298235 Hs.101689 ESTs 1.00 167.00

444513 AL120214 Hs.7117 glutamate receptor, ionotropic, AMPA 1 1.00 151.00

444527 NM 005408 Hs.11383 small inducible cytokine subfamily A (Cy 46.47 153.00

444561 NMJ04469 Hs.11392 c-fos induced growth factor (vascular en 0.01 3.08

445279 R41900 Hs.22245 ESTs 0.60 141.00

446017 N98238 Hs.55185 ESTs 0.18 2.39

446984 AB020722 Hs.16714 Rho guanine exchange factor (GEF) 15 0.10 2.16

446998 N99013 Hs.16762 Homo sapiens mRNA; cDNA DKFZp564B2062 (f 0.01 2.53

447357 AI375922 Hs.159367 ESTs 0.46 2.64

448106 AI800470 Hs.171941 ESTs 18.05 296.00

448253 H25899 Hs.201591 ESTs 1.00 141.00

449275 AW450848 Hs.205457 periaxin 0.56 1.38

450400 AI694722 Hs.279744 ESTs 0.88 4.33

450696 AI654223 Hs.16026 hypothetical protein FLJ23191 0.52 2.08

450726 AW204600 Hs.250505 retinoic acid receptor, alpha 0.79 2.01

451497 H83294 Hs.284122 Wnt inhibitory factor-1 0.35 2.03

451533 NM 004657 Hs.26530 serum deprivation response (phosphalidyl 0.13 2.25

453636 R67837 Hs.169872 ESTs 1.00 116.00

458332 AI000341 Hs.220491 ESTs 1.00 192.00

459580 AA022888 Hs.176065 ESTs 0.20 2.98

400269 Eos Control 0.40 2.40

403421 NM_016369*:Homo sapiens claudin 18 (CLDN 0.53 1.77

407570 Z19002 Hs.37096 zinc finger protein 145 (Kruppel-like, e 0.01 3.18

412295 AW088826 Hs.117176 poly(A)-biπding protein, nuclear 1 0.56 1.74

414517 M24461 Hs.76305 surfactant, pulmonary-associated protein 0.64 1.50

417204 N81037 Hs.1074 surfactant, pulmonary-associated protein 0.33 1.16

418307 U70867 Hs.83974 solute earner family 21 (prostaglandin 0.53 1.55

418935 T28499 Hs.89485 carbonic anhydrase IV 0.20 1.28

421502 AF111856 Hs.105039 solute carrier family 34 (sodium phospha 0.78 1.90

421798 N74880 Hs.29877 N-acylsphingosine amidohydrolase (acid c 0.59 1.54 423354 AB011130 Hs.127436 calcium channel, voltage-dependent, alph 0.59 1.55

423738 AB002134 Hs.132195 airway trypsin-like protease 10.14 51.00

425211 M18667 Hs.1867 progastricsin (pepsinogen C) 0.35 1.62

425438 T62216 Hs.270840 ESTs 0.23 9.45

426828 NMJ00020 Hs.172670 activin A receptor type ll-like 1 0.03 1.71

427019 AA001732 Hs.173233 hypothetical protein FLJ 10970 0.01 1.49

428043 T92248 Hs.2240 uteraglobin 0.42 1.26

430280 AA361258 Hs.237868 interleukin 7 receptor 0.46 2.43

431433 X65018 Hε.253495 surfactant, pulmonary-associated protein 0.57 1.59

431723 AW058350 Hs.16762 Homo sapiens mRNA; cDNA DKFZp564B2062 (f 0.29 1.80

432985 T92363 Hs.178703 ESTs 0.32 2.27

441835 AB036432 Hs.184 advanced glycosylation end product-speci 0.31 1.51

442275 AW449467 Hs.54795 ESTs 0.55 1.78

443709 AI082692 Hs.134662 ESTs 0.00 3.02

444325 AW152618 Hs.16757 ESTs 0.32 2.49

450954 AI904740 Hs.25691 receptor (calcitonin) activity modifying 0.46 1.74

451558 NM 01089 Hs.26630 ATP-binding cassette, sub-family A (ABC1 0.52 1.87

453310 X70697 Hs.553 solute carrier family 6 (neurotransmitte 0.00 3.30

456855 AF035528 Hs.153863 MAD (mothers against deoapentaplegic, Dr 0.01 2.31

444342 NM.014398 Hs.10887 similar to lysosome-associated membrane 0.66 2.20

400754 Target Exon 1.00 297.00

401045 C11001883*:gi|6753278|ref|NP_033938.1|c 1.00 109.00

401083 NM_016582*:Homo sapiens peptide traπspor 0.89 1.39

402474 NM_004079:Homo sapiens cathepsin S (CTSS 1.45 4.47

402808 ENSP00000235229:SEMB. 1.00 1.87

403021 C21000030:gi|9955960|refjNP_063957.1|AT 1.00 149.00

403438 NM_031419*:Homo sapiens molecule posεess 1.06 2.96

403687 NM_007037*:Homo sapiens a disintegrin-li 0.04 4.89

403764 NM_005463:Homo sapiens heterogeneous nuc 1.00 225.00

404277 NM_019111*:Homo sapiens major histocompa 0.97 1.93

404288 NM_002944*:Homo sapiens v-ros avian UR2 1.00 68.00

404518 AI815601 CD83 antigen (activated B lymphocytes, i 0.02 1.83

405106 CI 1001637*:gi|5032241 |ref|NP_005?32.11 z 1.00 235.00

405381 Target Exon 1.00 93.00

406387 Target Exon 1.37 6.02

406646 M33600 major histocompatibility complex, class 0.86 2.46

406714 AI219304 Hs.266959 hemoglobin, gamma G 0.01 3.19

406753 AA505665 Hs.217493 annexin A2 1.00 147.00

406973 M34996 Hs.198253 major histocompatibility complex, class 1.03 2.04

407248 U82275 Hs.94498 leukocyte immuπoglobulin-like receptor, 1.00 64.00

407510 U96191 gb:Human trophoblast hypoxia-regulated f 1.00 90.00

407731 NM.000066 Hs.38069 complement component 8, beta polypeptide 1.00 67.00

407830 NM 001086 Hs.587 arylacetamide deacetylase (esterase) 1.00 102.00

408045 AW138959 Hs.245123 ESTs 1.00 70.00

408074 R20723 ESTs 1.00 112.00

408374 AW025430 Hs.155591 forkhead box F1 0.07 10.17

409064 AA062954 Hs.141883 ESTs 0.39 2.31

409083 AF050083 Hs.673 interleukin 1 A (natural killer cell sti 1.00 95.00

409153 W03754 Hs.50813 hypothetical protein FLJ20022 0.01 4.55

409203 AA780473 Hs.687 cytochrome P450, subfamily IVB, polypept 0.01 3.72

409238 AL049990 Hs.51515 Homo sapiens mRNA; cDNA DKFZp564G112 (fr 1.00 79.00

409389 AB007979 Hs.301281 Homo sapiens mRNA, chromosome 1 specific 0.14 27.35

409718 D86640 Hs.56045 src homology three (SH3) and cysteine rl 1.00 113.00

410798 BE178622 Hs.16291 gb:PM3-HT0605-270200-001-a02 HT0605 Homo 0.64 2.47

411020 NM 006770 Hs.67726 macrophage receptor with collagenous εtr 0.55 2.40

411667 BE160198 gb:QV1-HT0413-010200-059-h03 HT0413 Homo 1.00 111.00

412000 AW576555 Hs.15780 ATP-binding cassette, sub-family A (ABC1 1.00 95.00

412358 BE047490 Hs.24172 ESTs 1.00 87.00

412420 AL035668 Hs.73853 bone morphogeπetic protein 2 1.43 8.07

412564 X83703 Hs.31432 cardiac ankyrin repeat protein 0.02 3.07

412869 AA290712 Hs.82407 CXC chemokine ligand 16 0.93 1.72

412870 N22788 Hs.82407 CXC chemokine ligand 16 0.97 1.51

413529 U11874 Hs.846 interleukin 8 receptor, beta 0.02 2.42

413533 BE146973 gb:QV4-HT0222-011199-019-e05 HT0222 Homo 0.65 1.50

413689 BE157286 Hs.20631 zinc finger protein, subfamily 1 A, 5 (Pe 20.87 232.00

413724 AA131466 Hs.23767 hypothetical protein FLJ12666 1.00 80.00

413800 AI129238 Hs.192235 ESTs 1.00 85.00

413802 AW964490 Hs.32241 ESTs, Weakly similar to S65657 alpha-1 C- 1.00 213.00

413829 NM.001872 Hs.75572 carboxypeptidase B2 (plasma) 0.02 3.93

414376 BE393856 Hs.66915 ESTs, Weakly similar to 16.7Kd protein [ 1.00 115.00

414577 AI056548 Hs.72116 hypothetical protein FLJ20992 similar k> 0.49 1.94

414700 H63202 Hs.38163 ESTs 0.03 3.75

415078 AA311223 Hs.283091 found in inflammatory zone 3 0.86 1.95

415120 N64464 Hs.34950 ESTs 1.00 120.00

415323 BE269352 Hs.949 neutrophil cytosolic factor 2 (65kD, chr 0.60 2.48

415335 AA847758 Hs.111030 ESTs 1.00 95.00

415582 W92445 Hs.165195 Homo sapiens cDNA FLJ14237 fis, clone NT 1.00 136.00

416030 H15261 Hs.21948 ESTs 0.02 8.07

416427 BE244050 Hs.79307 Rac/Cdc42 guanine exchange factor (GEF) 1.00 73.00

416464 NM 000132 Hs.79345 coagulation factor VIII, procoagulant co 0.70 3.36

416585 ^' X54162 Hs.79386 leiomodin 1 (smooth muscle) 0.06 6.56

416847 L43821 Hs.80261 enhancer of filamentation 1 (cas-likedo 0.70 3.66

417148 AA359896 Hs.293885 hypothetical protein FLJ14902 1.00 114.00

417370 T28651 Hs.82030 tryptophanyl-tRNA synthetase 0.85 1.30

417673 T87281 Hs.16355 ESTs 0.15 15.54 418067 AH 27958 Hs.83393 cyεtatin E/M 0.81 1.74

418296 C01566 Hs.86671 ESTs 1.00 99.00

418643 J03798 Hs.86948 small nuclear ribonucleoprotein D1 polyp 1.00 60.00

418832 X04011 Hs.88974 cytochrome b-245, beta polypeptide (chro 2.40 14.74

418945 BE246762 Hs.89499 arachidonate 5-lipoxygenase 0.67 ^• 3.16

419261 X07876 Hs.89791 wingless-type MMTV integration site fami 1.00 73.00

419564 U08989 Hε.91139 εolute carrier family 1 (πeuronal/epithe 1.00 192.00

419574 AK001989 Hε.91165 hypothetical protein 1.00 94.00

419968 X04430 Hε.93913 interleukin 6 (interferon, beta 2) 61.16 500.00

420256 U84722 Hs.76206 cadherin 5, type 2, VE-cadherin (vascula 0.52 1.70

420285 AA258124 Hs.293878 ESTs, Moderately similar to ZN9LHUMAN Z 1.00 172.00

420577 AA278436 Hs.186649 ESTε 1.00 97.00

421262 AA286746 Hs.9343 Homo sapiens cDNA FLJ14265 fis, clone PL 1.00 64.00

421445 AA913059 Hs.104433 Homo sapiens, clone IMAGE:4054868, mRNA 0.88 1.51

421470 R27496 Hs.1378 annexin A3 0.05 11.26

421478 AI683243 Hs.97258 ESTs, Moderately similar to S29539 ribos 1.00 73.00

421563 NM 006433 Hs.105806 granulysin 0.82 2.42

421566 NM_000399 Hs.1395 early growth reεponse 2 (Krox-20 (Drosop 5.50 31.57

421855 F06504 Hs.27384 ESTs, Moderately similar to ALU4JHUMAN A 1.00 129.00

421913 AI934365 Hs.109439 osteoglycin (osteoinductive factor, mime 1.00 101.00

421952 AA300900 Hs.98849 ESTs, Moderately similar to AF161511 1 H 0.60 63.60

422232 D43945 Hs.113274 transcription factor EC 1.00 148.00

422386 AF105374 Hs.115830 heparan sulfate (glucosamine) 3-O-εulfot 1.40 3.98

423168 R34385 Hs.124940 GTP-binding protein 0.34 3.59

423196 AK001866 Hs.125139 hypothetical protein FLJ11004 0.55 2.00

423387 AJ012074 vaεoactive intestinal peptide receptor 1 0.09 2.13

423424 AF150241 Hs.128433 prostaglandin D2synthase, hematopoietic 1.00 141.00

423456 AL110151 Hs.128797 DKFZP586D0824 protein 1.00 66.00

423696 Z92546 Sushi domain (SCR repeat) containing 0.73 1.27

424027 AW337575 Hs.201591 ESTs 0.54 2.58

424212 NM_005814 Hs.143131 glycoprotein A33 (transmembrane) 0.77 2.47

425087 R62424 Hs.126059 ESTs 1.00 74.00

425175 AF020202 Hs.155001 UNC13 (C. elegans)-like 0.85 1.96

425771 BE561776 Hs.159494 Bruton agammaglobullnemia tyrosine kinas 1.18 2.56

426486 BE178285 Hs.170056 Homo εapienε mRNA; cDNA DKFZp586B0220 (f 1.00 76.00

427507 AF240467 Hs.179152 toll-like receptor 7 1.00 63.00

427618 NM 000760 Hs.2175 colony stimulating factor 3 receptor (gr 0.60 2.19

427732 NM_002980 Hs.2199 secretin receptor 0.97 1.42

427952 AA765368 Hs.293941 ESTs, Moderately similar to A53959 throm 1.00 105.00

428709 BE268717 Hs.104916 hypothetical protein FLJ21940 1.00 80.00

428769 AW207175 Hs.106771 ESTs 0.09 2.55

428780 AI478578 Hs.50636 ESTs 1.00 98.00

428833 AI928355 Hs.185805 ESTs 1.00 113.00

429657 D13626 Hs.2465 KIAA0001 gene product; putative G-protei 1.00 52.00

430212 AA469153 gb:nc67f04.s1 NCI_CGAP_Pr1 Homo εapiens 1.00 132.00

430226 BE245562 Hs.2551 adrenergic, beta-2-, receptor, surface 0.11 15.60

430376 AW292053 Hs.12532 chromosome 1 open reading frame 21 1.00 103.00

430414 AW365665 Hs.120388 ESTs 0.50 6.96

430656 AA482900 Hs.162080 ESTs 1.00 70.00

430843 AI734149 Hs.119514 ESTs 1.00 90.00

430998 AF128847 Hs.204038 indolethylamine N-methyltransferaεe 0.29 1.84

431217 NM 013427 Hs.250830 Rho GTPase activating protein 6 1.00 79.00

431921 N46466 Hε.58879 ESTs 0.91 1.67

432176 AW090386 Hs,112278 arrestin, beta 1 0.66 2.63

432203 AA305746 Hs.49 macrophage scavenger receptor 1 1.00 76.00

432231 AA339977 Hε.274127 CLST 11240 protein 0.46 1.46

432485 N90866 Hs.276770 CDW52 antigen (CAMPATH-1 antigen) 0.79 2.25

432522 D11466 Hs.51 phosphatidylinositol glycan, claεε A (pa 1.93 4.83

432596 AJ224741 Hs.278461 matrilin 3 0.04 5.79

432850 X87723 Hs.3110 angiotensin receptor 2 1.00 167.00

433138 AB029496 Hs.59729 semaphorin sem2 0.04 9.16

433563 AI732637 Hs.277901 ESTs 1.00 91.00

433588 AI056872 Hs.133386 ESTs 120.16 315.00

434445 AI349306 Hs.11782 ESTs 0.60 1.84

435496 AW840171 Hs.265398 ESTs, Weakly similar to transformation-r 1.00 128.00

435974 U29690 Hs.37744 Homo εapiens beta-1 adrenergic receptor 1.00 108.00

436061 AI248584 Hs.190745 Homo sapiens cDNA: FLJ21326 fis, clone C 1.00 91.00

437157 BE048860 Hs.120655 ESTs 1.00 87.00

437207 T27503 Hs.15929 hypothetical protein FLJ12910 1.00 105.00

437311 AA370041 Hs.9456 SWI/SNF related, matrix associated, acti 1.00 71.00

437439 H29796 Hs.269622 ESTs 1.00 115.00

438199 AW016531 Hs.122147 ESTs 1.00 80.00

439551 W72062 Hs.11112 ESTs 0.30 3.10

440515 AJ131245 Hs.7239 SEC24 (S. cerevisiae) related gene famil 1.00 77.00

440887 AI799488 Hs.135905 ESTs 1.00 85.00

441025 AA913880 Hs.176379 ESTs 1.00 82.00

441384 AA447849 Hs.288660 Homo sapiens cDNA: FLJ22182 fis, clone H 0.79 1.89

441735 AI738675 Hs.127346 ESTs 1.00 75.00

442200 AW590572 Hs.235768 ESTs 0.78 5.83

442832 AW206560 Hs.253569 ESTs 0.03 10.88

442957 AI949952 Hs.49397 ESTs 1.00 70.00

443282 T47764 Hs.132917 ESTs 1.00 197.00

443547 AW271273 Hs.23767 hypothetical protein FLJ12666 1.00 253.00

443951 F13272 Hs.111334 ferritin, light polypeptide 0.55 2.09

444330 AI597655 Hs.49265 ESTs 1.00 90.00 444515 AW204908 Hs.169979 ESTs 1.00 84.00

445769 AI741471 Hs.23666 ESTs 0.02 4.38

445908 R13580 Hs.13436 Homo sapiens clone 24425 mRNA sequence 1.00 97.00

446291 BE397753 Hs.14623 interferon, gamma-inducible protein 30 0.93 1.69

446917 AI347863 Hs.156672 ESTs 1.00 106.00

447261 NM 006691 Hs.17917 extracellular link domain-containing 1 0.40 47.20

447432 AW958473 Hs.301957 nudix (nucleoside diphosphate linked moi 1.00 100.00

447482 AB033059 Hs.18705 KIAA1233 protein 0.05 8.21

447997 H00656 Hs.29792 ESTs, Weakly similar to I38022 hypotheti 0.02 5.42

448299 AA497044 Hs.20887 hypothetical protein FLJ 10392 1.00 79.00

448782 AL050295 Hs.22039 KIAA0758 protein 0.42 1.56

450575 NM 005859 Hs.29117 purine-rich element binding protein A 0.17 11.33

450584 AA040403 Hs.60371 ESTs 1.00 94.00

450693 AW450461 Hs.203965 ESTs 1.00 91.00

450715 AI266484 Hs.31570 ESTs, Weakly similar to KIAA1324 protein 1.00 152.00

451103 R52804 Hs.25956 DKFZP564D206 protein 1.00 86.00

451220 AF124251 Hs.26054 novel SH2-containing protein 3 0.60 1.30

451668 Z43948 Hs.326444 cartilage acidic protein 1 0.54 1.91

452197 AW023595 Hs.232048 ESTs 1.00 67.00

452331 AA598509 Hs.29117 purine-rich element binding protein A 4.53 11.07

452353 C18825 Hs.29191 epithelial membrane protein 2 0.72 2.24

453049 BE537217 Hε.30343 ESTs 1.00 68.00

453107 NM.016113 Hs.279746 vanilloid receptor-like protein 1 0.83 1.70

453355 AW295374 Hs.31412 Homo sapienε cDNA FLJ11422 fis. clone HE 1.00 132.00

453390 AA862496 Hs.28482 ESTs 1.00 72.00

453531 AA417940 ESTs, Weakly similar to JC5795 CDEP prot 1.00 68.00

454741 BE154396 gb:CM2-HT0342-091299-050-b05 HT0342 Homo 0.57 2.89

456579 AA287827 Hs.284205 up-regulated by BCG-CWS 1.00 82.00

456672 AK002016 Hs.114727 Homo sapiens, clone MGC: 16327, mRNA, com 0.79 1.96

457400 AF032906 Hs.252549 cathepsin Z 1.03 3.25

457718 F18572 Hs.22978 ESTs, Weakly similar to ALU4.HUMAN ALU S 1.00 113.00

459696 F03027 gb:HSC1KA072 normalized infant brain cDN 1.00 544.00

TABLE 10B

Pkey: Unique Eos probeset identifier number

CAT number: Gene cluster number Accesεion: Genbank accession numbers

Pkey CAT Number Accession 408074 103684.1 R20723 AA263003 AA333976 AA334725 AA334151 AW965490 AA310513 AI810530 D31302 AW134897 AA830127 AA046953 AI668930

C06094AW104534

411667 1253334.1 BE160198 AW935898 T11520 AW935930 AW856073 AW861034 413533 1375344.1 BE146973 BE146972 BE147042 BE147018 BE146783 BE147020 BE146781 BE147019 BE146766 BE147021 BE146952 BE146767 BE147044

BE146797 BE146776 BE146985 BE146793 BE146768 BE146771 BE146954 BE146760 BE147048 BE147025 BE147030

423387 22779.1 AJ012074 U11087 L13288 X75299 L20295 AW630780 H14880 T28037 AI872991 R72136 AW449839 T81622 T79697 T29519 R94105 T83923

R73300 AI797007 R73390 AA961010 H74168 AI689932 BE045543 AI808418 AI608912 AI806573 AW884084 AW872978 AW872985 AA565655

AI022915 R50647 R73210 H45098 R46451 AW166269 T71132 AI264547 R52146 AI304920 R73391 AW884059 AW884085 H73241 T60038

T79612 R73145 R50549 AI094557 AI668793 R72302 AI564366 W01956 AA418962 W32571 R72840 H45409 R72085 R46356 R46758

AA508805 AA418798 T83751 R94072 T16182 AA928785 AA903896

423696 23112J Z92546 AA330586 AI570568 AW341487 AI827050 AW298668 AI792189 AI015693 AI733599 AI572251 AI672488 AW193262 AI244716

AI864375 AI206100 AA912444 AI269365 AI640254 AW772466 AI867336 AA627604 H16914 AA358477 AA338009

430212 314437 1 AA469153 AI718503 AA469225 436532 421802J AA721522AW975443T93070 453531 97026.1 AA417940AA036735T07025 454741 1232559 1 BE154396 AW817959 BE154393

TABLE 10C

Pkey: Unique number corresponding to an Eos probeset

Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. "Dunham I. et al." refers to the publication entitled "The DNA sequence of human chromosome 22." Dunham I. et al., Nature (1999) 402:489-495. Strand: Indicates DNA strand from which exons were predicted. NLposition: Indicates nucleotide positions of predicted exons.

Pkey Ref Strand NLposition

400754 7331445 Plus 144559-144684

401045 8117619 Plus 90044-90184,91111-91345

401083 3242744 Plus 33192-33360

402474 7547175 Minus 53526-53628,55755-55920,57530-57757

402808 6456148 Minus 114964-115136,115461-115585,115931-116047,117666-117771,118004-118102

403021 7547270 Plus 120799-120966

403421 9665041 Minus 126609-126773,139986-140205

403438 9719679 Plus 90792-90938

403687 7387384 Plus 9009-9534

403764 7717105 Minus 118692-118853

404277 1834458 Minuε 91665-91946

404288 2769644 Plus 3512-3691

404394 3135305 Minus 37121-37205,37491-37762,4105341140,41322-41593,41773-41919

404518 8151988 Plus 84494-84603

404916 7341826 Plus 91057-91188

405106 8079395 Minus 80877-81418

405257 7329310 Plus 73121-73273

405381 6006920 Minus 7636-8054 406387 9256180 Plus 116229-116371,117 - 765

TABLE 11 A: Genes Distinguishing Adenocarcinoma from Other Lung Diseases and Normal Lung

Table 11 A shows about 84 genes upregulated in lung adenocarcinomas relative to other lung tumors, non-malignant lung diseaεe, and normal lung. These genes were selected from about 59680 probesets on the Eos/Affymetrix Hu03 Genechip array.

Table 11 B show the accession numbers for those Pkey's lacking UnigenelD'ε for table 11 A. For each probeset we have listed the gene cluster number from which the oligonucleotides were designed. Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAε. Theεe sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California). The Genbank accesεton numbers for sequences comprising each cluster are listed in the "Accession" column.

Table 11 C show the genomic positioning for those Pkey's lacking Unigene ID's and accession numbers in table 11 A. For each predicted exon, we have listed the genomic εequence source used for prediction. Nucleotide locations of each predicted exon are also listed.

Pkey: Unique Eos probeset identifier number

ExAccn: Exemplar Accession number, Genbank accession number

UnigenelD: Unigene number

Unigene Title: Unigene gene title

R1: Average of lung tumors (including squamouε cell carcinomas, adenocarcinomas, small cell ι carcinomε average of normal lung samples

R2: Average of non-malignant lung diεease samples (including bronchitis, emphysema, fibrosis, atelectas

Pkey ExAccn UnigenelD Unigene Title R1 R2

403329 Target Exon 1.00 61.00

406399 NM_003122*:Homo sapiens serine protease 1.00 39.00

406690 M29540 Hs.220529 carcinoembryonic antigen-related cell ad 226.37 350.00

407869 A1827976 Hs.24391 hypothetical protein FLJ 13612 0.77 1.18

407881 AW072003 Hs.40968 heparan sulfate (glucosamine) 3-O-sulfot 1.00 10.00

408908 BE296227 Hs.250822 serine/threonine kinase 15 7.76 1.00

409103 AF251237 Hs.112208 XAGE-1 protein 80.44 40.00

409187 AF154830 Hs.50966 carbamoyl-phosphate synthetase 1, mitoch 1.00 1.00

409269 AA576953 Hs.22972 hypothetical protein FLJ13352 1.00 1.00

410076 T05387 Hs.7991 ESTs 1.12 1.50

410102 AW248508 Hs.279727 Homo sapiens cDNA FLJ14035 fis, clone HE 9.89 1.00

410399 BE068889 synuclein, gamma (breast cancer-εpecific 0.92 1.06

411908 L27943 Hs.72924 cytidine deaminase 1.00 1.00

412612 NMJ00047 Hs.74131 arylsulfatase E (chondrodyεplaεia puncta 1.02 1.03

414075 U11862 Hs.75741 amiloride binding protein 1 (amine oxida 0.84 1.07

416208 AW291168 Hs.41295 ESTs, Weakly similar to MUC2_HUMAN MUCIN 3.67 1.00

417542 J04129 Hs.82269 progestagen-associated endometrial prate 1.28 1.35

419183 U60669 Hs.89663 cytochrome P450, subfamily XXIV (vitamin 1.00 1.00

419502 AU076704 fibrinogen, A alpha polypeptide 13.05 115.00

419631 AW188117 Hs.303154 popeye protein 3 1.00 13.00

420931 AF044197 Hs.100431 small inducible cytokine B subfamily (Cy 1.00 8.00

421155 H87879 Hs.102267 lyεyl oxidase 1.00 15.00

421190 U95031 Hs.102482 mucin 5, subtype B, tracheobronchial 1.17 1.55

421474 U76362 Hs.104637 solute carrier family 1 (glutamate trans 1.46 1.76

421515 Y11339 Hε.105352 GalNAc alpha-2, 6-sialyltransferase 1, 1 1.00 3.00

421582 AI910275 trefoil factor 1 (breast cancer, estroge 1.23 1.00

422026 U80736 Hs.110826 trinucleotide repeat containing 9 1.00 52.00

422095 AI868872 Hs.282804 hypothetical protein FLJ22704 4.37 2.34

422311 AF073515 Hs.114948 cytokine receptor-like factor 1 1.15 1.78

422867 L32137 Hs.1584 cartilage oligo erio matrix protein (pse 1.69 3.17

423472 AF041260 Hs.129057 breaεt carcinoma amplified sequence 1 48.13 72.00

423554 M90516 Hs.1674 glutamine-fructose-6-phosphate transamin 1.00 50.00

424502 AF242388 Hs.149585 lengsin 1.00 1.00

424544 MB8700 Hs.150403 dopa decarboxylase (aromatic L-amino aci 1.00 59.00

424905 NM 02497 Hs.153704 NIMA (never in mitosis gene a)-related k 21.35 1.00

424960 BE245380 Hs.153952 5' nucleotidase (CD73) 1.00 1.00

425523 AB007948 Hs.158244 KIAA0479 protein 1.00 35.00

426230 AA367019 Hε.241395 protease, serine, 1 (trypsin 1) 1.00 83.00

427701 AA411101 Hs.243886 nuclear autoantigenic sperm protein (his 7.41 34.00

428585 AB007863 Hs.185140 KIAA0403 protein 1.00 6.00

428758 AA433988 Hs.98502 hypothetical protein FLJ14303 1.06 1.13

429170 NM 001394 Hs.2359 dual specificity phosphatase 4 16.18 105.00

429263 AA019004 Hs.198396 ATP-binding cassette, sub-family A (ABC1 1.07 1.00

429610 AB024937 Hs.211092 LUNX protein; PLUNC (palate lung and nas 1.59 1.69

430508 AI015435 Hs.104637 ESTs 4.75 7.27

430985 AA490232 Hs.27323 ESTs, Weakly similar to I78885 serine/th 0.94 1.28

431548 AI834273 Hs.9711 novel protein 5.66 15.00

431566 AF176012 Hs.260720 J domain containing protein 1 49.76 37.00

431986 AA536130 Hs.149018 Novel human gene mapping to chomosome 20 1.19 1.47

432375 BE536069 Hs.2962 S100 calcium-binding protein P 1.65 1.06

432677 NM_004482 Hs.278611 UDP-N-acetyl-alpha-D-galactosamine:polyp 1.00 48,00

433556 W56321 Hs.111460 calcium/calmodulin-dependent protein kin 1.00 19.00

433819 AW511097 Hs.112765 ESTs 3.71 8.00

434001 AW950905 Hs.3697 serine (or cysteine) proteinase inhibito 29.31 72.00

434424 A1811202 Hs.325335 Homo sapiens cDNA: FLJ23523 fis, clone L 1.00 64.00

434792 AA649253 Hs.132458 ESTs 8.52 44.00

436217 T53925 Hs.107 fibrinogen-like 1 57.97 31.00

436749 AA584890 Hs.5302 lectin, galactoside-binding, soluble, 4 1.10 1.41

436972 AA284679 Hε.25640 claudin 3 1.59 1.46

437866 AA156781 metallothionein 1E (functional) 3.62 101.00

437935 AW939591 Hs.5940 mucin 13, epithelial transmembrane 1.60 1.39

438915 AA280174 Hs.285681 Williams-Beuren syndrome chromosome regi 1.00 1.00

439451 AF086270 Hs.278554 heterochromalin-like protein 1 23.28 52.00 439759 AL359055 Hs.67709 Homo sapiens mRNA full length insert cDN 1.00 21.00 441031 AH 10684 Hs.7645 fibrinogen, B beta polypeptide 1.41 99.00 441377 BE218239 Hs.202656 ESTs 22.03 1.00 443614 AV655386 Hs.7645 fibrinogen, B beta polypeptide 1.00 16.00 443813 AA876372 Hs.93961 Homo sapiens mRNA; cDNA DKFZp667D095 (fr 1.20 1,99 443991 NM_002250 Hs.10082 potassium intermediate/small conductance 5.71 6.87 444670 H58373 Hε.332938 hypothetical protein MGC5370 1.98 38.00 444931 AV652066 Hε.75113 general transcription factor IIIA 1.00 54.00 446102 AW168067 Hs.317694 ESTs 1.00 1.00

10 446163 AA026880 Hs.25252 Homo sapiens cDNA FLJ13603 fis, clone PL 1.00 36.00 446469 BE094848 Hs.15113 homogentisate 1,2-dioxygenase (ho ogenti 1.00 11.00 447388 AW630534 Hs.76277 Homo sapiens, clone MGC:9381, mRNA, comp 1.24 1.16 447532 AK000614 Hs.18791 hypothetical protein FLJ20607 1.23 1.63 448243 AW369771 Hs.52620 integrin, beta 8 15.84 1.00

15 448844 AI581519 Hs.177164 ESTs 1.00 31.00 449444 AW818436 Hs.23590 solute carrier family 16 (monocarboxylic 1.00 83.00 451807 W52854 hypothetical protein FLJ23293 similar to 1.55 35.00 452689 F33868 Hs.284176 transferrin 1.54 1.44 453392 U23752 Hs.32964 SRY (sex determining region Y)-box 11 1.00 16.00

20 453464 A1884911 Hs.32989 receptor (calcitonin) activity modifying 1.55 2.45 453735 AI066629 Hs.125073 ESTs 1.01 1.30

TABLE 11B

25 Pkey: Unique Eos probeset identifier number

CAT number: Gene cluster number Accession: Genbank accession numbers

Pkey CAT Number Accession

30 410399 11995 1 BE068889 BE068882AF044311 AF017256 NM 003087 AF037207 AF010126 AA633976 AA872836 BE298825 BE299889 AI016464 AI684600

A1936527 AA804675 AA394097 AI139933 AA946606 BE171313 AA722407 AA293803 AI468480 AA056035 AA055968 AW796957 AI637713 AA410737 H49348 AA486472 AA411094 AA235594 AA402624 AA443638 AW452137 AA421708 AW265211 AI493266 AA365132 AW966044 419502 18535 1 AU076704 T74854 T74860 T72098 T73265 T73873 T69180 T74658 T58786 T60385 T73410 T68781 T67845 T67593 T73952 T67864 T60630

T68367 T68401 T53959 T72360 T72099 T60377 T58961 T71712 T72821 T64738 T74645 T72Q37 T68688 T72063 T73258 T72826 T64242

35 T68220 T74673 T71800 T68355 T61227 T62738 T69317 T53850 T64692 T73768 T73962 T73382 T68914 T70975 T73400 T60631 T73277

T73203 T70498 T61409 T58925 NM 000508 M64982 T68301 T73729 T69445 T60424 T67922 T67736 T68716 T67755 T74765 T73819 T58719 T74756 T60477 T74863 T61109 T68329 T58850 T71857 T73425 T53736 T68607 T58898 T64309 T72031 T72079 T64305 T71908 T68107 T71916 T73787 T56035 T64425 T71870 T60476 T61376T67820 T71895 T41006 T69441 T68170 T74617 T71958 T69440 T61875 R06796 H48353 T71914 T53939 T64121 AA693996 T72525 T67779 T68078 AA011465 AA345378 AV654847 AV654272 AV656001 AI064740 T82897

40 N33594 AA344542 AW805054 AI207457 T61743 AA026737 H94389 AA382695 AA918409 T68044 S82092 T39959 AI017721 AA312395

AA312919 T40156 H66239 AV652989 H38728 R98521 AV655200 R95790 W03250 W00913 AA344136 AV660126 R97923 AA343596 AW470774 AV651256 N54417 AA812862 AW182929 All 11192 H61463 H72060 AA344503 H38639 AI277511 AV661108 AI207625 T47810 AA235252 T27853 T47778 R95746 H70620 AA701463 AW827166 R98475 C20925 AV657287 T71959 T71313 T73920 T73333T61618 T69293 . , T69283 T73931 T72178 T72456 AV645639 AV653476 T72957 T72300 T58906 T71457 T70494 T72956 T70495 T68267 T74407 T85778

45 AA344726 T27854 T74485 T74101 T73868 T71518 T72304 AA343853 T73909 T68070 T72065 H72149 T73493 T73495 AV645993 R02293

T70475 T64751 AA344441 AA343657 AA345732 AA344328 AH 10639 AA344603 AF063513 T64696 T68516 T72223 T60507 T67633 R29500 T72517 R02292 T60599 T69206 T70452 T74677 R29366 T61277 T74914 T60352 R29675 T74843 AV645792 AA344408 T69197 T72057 T69368 T69358 T68258 AV650429 T73341 T61702 T74598 T40095 K02272 T40106 AA343045 AA341908 AA341907 AA342807 AA341964 T53747 T72042 T62764 AI064899 AA343060 T67832 T72440 T71770 T68091 T69108 T72449 T69167 T71289 T68251 AV654844 T64375

50 AA346234 T67598 AA011414 T68036 H48262 AI207557 T68219 W86031 T69081 T64232 R93196 T62136 AV650539 H67459 T72978

AA344583 T60362 H58121 T95711 T72803 T68055 T71715 R29036 T72793 T69122 T64595 T62888 T69139 T68291 T64652 T67971 T46862 AA693592 AI248502 R29454 T64764 T57001 T73052 T71429 T51176 T58866 AV655414 H90426 AA342489 T73666 T67848 T72512 T53835 T67837 T73317 T74273 T69420 T68245 T74380 T67862 T74474 T56068

, _ 421582 2041 1 AI910275 X00474 X52003 X05030 NM 003225 AA314326 AA308400 AA506787 AA314825 AI571948 AA507595 AA614579 AA587613 R83818

55 AA56B312AA614409 AA307578AI925552AW950155 AI910083 M12075 BE074052 A 004668 AA578674 AA582084 BE074053 BE074126

BE074140 AA514776 AA588034 BE074051 BE074068 AW009769 AW050690 AA858276 R55389 AI001051 AW050700 AW750216 AA614539 BE074045 AI307407 AW602303 BE073575 A1202532 AA524242 AI970839 AI909751 BE076078 AI909749 R55292 437866 44433 2 AA156781 AW293839 U52054 AA024963 AA778446 BE073977 AW444904 AW602574 BE164040 BE164012 BE163972 BE163974 BE163992

,.. AA837481 AW468444 BE185091 AW468002 AA687333 AA811830 AA581806 A1866686 AI572124 AA043777 AA040926 D20160AI536733

60 AA812489 AW874142 AI471883 W84421 AA156850

451807 8865.1 W52854AL117600 BE208116 BE208432 BE206239 BE082291 AW953423 AA351619 BE180648 BE140560 W60080 AA865478 N90291

AW450652 AW449519 AA993634 AI806539 AA351618 AW449522 AI827626 AA904788 AA380381 AA886045 AA774409 BE003229 Z41756

65 TABLE 11C

Pkey: Unique number corresponding to an Eos probeset

Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. "Dunham I. et al." refers to the publication entitled "The DNA sequence of human chromosome 22." Dunham I. et al., Nature (1999) 402:489495.

70 Strand: Indicates DNA strand from which exons were predicted.

NLposition: Indicates nucleotide positions of predicted exons.

Pkey Ref Strand NLposition

403329 8516120 Plus 96450-96598

75 406399 9256288 Minus 63448-63554 TABLE 12A: Geneε Diεtinguishing Squamous Cell Carcinoma from Other Lung Diseases and Normal Lung

Table 12A shows about 72 genes upregulated in squamouε cell carcinomas ofthe lung relative to other lung tumors, non-malignant lung diseaεe, and normal lung. These genes were selected from about 59680 probesets on the Eos/Affymetrix Hu03 Genechip array.

Table 12B show the accession numbers for those Pkey's lacking UnigenelD's for table 12A. For each probeset we have listed the gene cluster number from which the oligonucleotides were designed. Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs. These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California). The Genbank accession numbers for sequences comprising each cluster are listed in the "Accession" column.

Table 12C show the genomic positioning for those Pkey's lacking Unigene ID's and accesεion numbers in table 12A. For each predicted exon, we have listed the genomic sequence source used for prediction. Nucleotide locations of each predicted exon are also listed.

Pkey: Unique Eos probeset identifier number

ExAccn: Exempli ar Accession number, Genbank accesεioπ number

UnigenelD: Unigene number

Unigene Title: Unigene gene title

R1: Average of lung tumors (including squamous cell carcinomas, adenocarcinomas, small cell carcinomas, c average of normal lung εamples

R2: Average of non-malignant lung diseaεe εamples (including bronchitis, emphysema, fibrosis, atelectasis, i

Pkey ExAccn UnigenelD Unigene Title R1 R2

400289 X07820 Hs.2258 matrix metalloproteinase 10 (stromelysin 132.45 4.00

400666 NM_002425:Homo sapiens matrix metallopro 3.26 3.22

401780 NM_005557*:Homo sapiens keratin 16 (foca 26.47 10.50

401781 Target Exon 10.33 4.61

401785 NM_002275-:Homo sapienε keratin 15 (KRT1 4.13 2.70

401994 Target Exon 61.84 47.00

402075 ENSP00000251056*:Plasma membrane calcium 1.00 1.00

404996 Target Exon 1.00 1.00

407839 AA045144 Hs.161566 ESTs 173.91 108.00

408000 L11690 Hs.620 bullous pemphigoid antigen 1 (230/240kD) 151.17 8.00

408522 AI541214 Hs.46320 Small proline-rich protein SPRK [human, 1.98 1.24

410561 BE540255 Hs.6994 Homo sapiens cDNA: FLJ22044 fis, clone H 10.04 1.00

415091 AL044872 Hs.77910 3-hydroxy-3-methylglutaryl-Coenzyme A sy 1.00 30.00

415817 U88967 Hs.78867 protein tyrosine phosphatase, receptor-t 24.30 1.00

416658 U03272 Hs.79432 fibrillin 2 (congenital coπtractural ara 53.29 51.00

417034 NM 006183 Hs.80962 neurotensin 1.00 1.00

417366 BE185289 Hs.1076 small proline-rich protein 1B (cornifin) 8.97 3.27

418663 AK001100 Hs.41690 desmocollin 3 112.17 19.00

418678 NM.001327 Hs.87225 cancer/testis antigen 1.18 1.10

419121 AA374372 Hs.89626 parathyroid hormone-like hormone 1.00 1.00

420783 AI659838 Hs.99923 iectin, galactoside-binding, soluble, 7 3.04 1.25

421773 W69233 Hs.112457 ESTs 1.12 1.14

421948 L42583 Hs.334309 keratin 6A 51.83 20.25

421978 AJ243662 Hs.110196 NICE-1 protein 1.01 0.91

422158 L10343 Hs.112341 protease inhibitor 3, skin-derived (SKAL 2.37 1.10

422440 NM 004812 Hs.116724 aldo-keto reductase family 1, member B10 47.53 32.00

423634 AW959908 Hs.1690 heparin-binding growth factor binding pr 76.02 1.00

423725 AJ403108 Hs.132127 hypothetical protein LOC57822 4.20 1.00

423738 AB002134 Hs.132195 airway trypsin-like protease 10.14 51.00

424012 AW368377 Hs.137569 tumor protein 63 kDa with strong homolog 233.42 68.00

424046 AF027866 Hs.138202 serine (or cysteine) proteinase inhibito 1.00 1.00

424098 AF077374 Hs.139322 small proline-rich protein 3 137.82 54.00

424834 AK001432 Hs.153408 Homo sapiens cDNA FLJ10570 fis, clone NT 56.19 12.00

425650 NM 001944 Hs.1925 desmoglein 3 (pemphigus vulgaris antigen 33.45 1.00

427099 AB032953 Hs.173560 odd Oz/ten-m homolog 2 (Drosophila, mous 4.24 17.00

427335 AA448542 Hs.251677 G antigen 7B 51.83 4.00

428182 BE386042 Hs.293317 ESTs, Weakly similar to GGC1.HUMAN G ANT 1.00 1.00

428645 AA431400 Hs.98729 ESTε, Weakly similar to 2017205A dihydro 1.00 16.00

428748 AW593206 Hs.98785 Ksp37 protein 1.00 87.00

429259 AA420450 Hs.292911 ESTε, Highly similar to S60712 band-6-pr 2.01 1.18

429538 BE182592 Hs.11261 small proline-rich protein 2A 4.43 2.90

429903 AL134197 Hs.93597 cyclin-dependent kinase 5, regulatory su 11.80 1.00

430486 BE062109 Hs.241551 chloride channel, calcium activated, fam 12.28 41.00

430890 X54232 Hs.2699 glypican 1 1.58 1.40

431009 BE149762 Hs.48956 gap junction protein, beta 6 (connexin 3 60.25 28.00

431846 BE019924 Hs.271580 uroplakin 1B 4.49 2.51

433091 Y12642 Hs.3185 lymphocyte antigen 6 complex, locus D 1.20 1.09

434360 AW015415 Hs.127780 ESTs 40.98 27.00

434880 U02388 Hs.101 cytochrome P450, subfamily IVF, polypept 1.00 1.00

435505 AF200492 Hs.211238 interleukiπ-1 homolog 1 1.00 38.00

435793 AB037734 Hs.4993 KIAA1313 protein 23.68 42.00

436511 AA721252 Hs.291502 ESTs 16.76 14.00

438403 AA806607 Hs.292206 ESTs 1.00 1.00

439285 AL133916 hypothetical protein FLJ20093 46.23 139.00

439606 W79123 Hs.58561 G protein-coupled receptor 87 33.61 1.00

439670 AF088076 Hs.59507 ESTs, Weakly similar to AC0048583 U1 sm 1.00 1.00

439706 AW872527 Hs.59761 ESTs, Weakly similar to DAP1.HUMAN DEATH 86.55 11.00

440325 NM 003812 Hs.7164 a disintegrin and metalloproteinase doma 62.88 147.00

441525 AW241867 Hs.127728 ESTs 1.53 1.42

443162 T49951 Hs.9029 DKFZP434G032 protein 31.11 38.00

444378 R41339 Hs.12569 ESTs 1.00 1.00 446292 AF081497 Hs.279682 Rh type C glycoprotein 1.55 1.26

447078 AW885727 Hs.9914 ESTs 47.24 24.00

447342 AI199268 Hs.19322 Homo sapiens, Similar to RIKEN cDNA 2010 28.63 1.00

449003 X76342 Hs.389 alcohol dehydrogenase 7 (class IV), mu o 1.00 1.00

449101 AA205847 Hs.23016 G protein-coupled receptor 2.58 27.00

450832 AW970602 Hs.105421 ESTs 25.17 36.00

452240 AI591147 Hs.61232 ESTs 13.42 1.00

453317 NM 002277 Hs.41696 keratin, hair, acidic, 1 1.19 1.27

453830 AA534296 Hs.20953 ESTs 24.92 25.00

454098 W27953 Hs.292911 ESTs, Highly similar to S60712 band-6-pr 1.26 1.11

455601 AI368680 Hs.816 SRY (sex determining region Y)-box 2 206.11 1.00

TABLE 12B

Pkey: Unique Eos probeset identifier number

CAT number: Gene cluster number Accesεion: Genbank accession numbers

Pkey CAT Number Accession

439285 47065 1 AL133916 N79113AF086101 N76721 AW950828 AA364013 AW955684 AI346341 AI867454 N54784 AI655270AI421279 AW014882

AA775552 N62351 N59253 AA626243A1341407 BE175639 AA456968 AI358918 AA457077

TABLE 12C

Pkey: Unique number corresponding to an Eos probeset Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. "Dunham I. et al." refers to the publication entitled 'The DNA sequence of human chromosome 22." Dunham I. et al., Nature (1999) 402:489495.

Strand: Indicates DNA strand from which exons were predicted. NLposition: Indicates nucleotide positions of predicted exons.

Pkey Ref Strand NLposition

400666 8118496 Plus 17982-18115,20297-20456

401780 7249190 Miπuε 28397-28617,28920-29045,29135-29296,29411-29567,29705-29787,30224-30573

401781 7249190 Minus 83215-83435,83531-83656,83740-83901,84237-84393,84955-85037,86290-86814

401785 7249190 Minus 165776-165996,166189-166314,166408-166569,167112-167268,167387-167469,168634-168942

401994 4153858 Minus 42904-43124,43211-43336,44607-44763,4519945281,4633746732

402075 8117407 Plus 121907-122035,122804-122921,124019-124161,124455-124610,125672-126076

404996 6007890 Plus 37999-38145,38652-38998,39727-39872,4055740674,4235142450

TABLE 13A: Genes Distinguishing Non-Malignant Lung Disease from Lung Tumors and Normal lung

Table 13A shows about 23 genes upregulated in non-malignant lung disease relative to lung tumors and normal lung. These genes were selected from about 59680 probesets on the Eos/Affymetrix Hu03 Genechip array.

Table 13B εhow the accession numbers for those Pkey's lacking UnigenelD's for table 13A. For each probeset we have listed the gene cluster number from which the oligonucleotides were designed. Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs. These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California). The Genbank accession numbers for sequences comprising each cluster are listed in the "Accession" column.

Table 13C show the genomic positioning for those Pkey's lacking Unigene ID's and accession numbers in table 13A. For each predicted exon, we have listed the genomic sequence source used for prediction. Nucleotide locations of each predicted exon are also listed.

Pkey: Unique Eos probeset identifier number

ExAccn: Exemplar Accesεion number, Genbank accession number

UnigenelD: Unigene number

Unigene Title: Unigene gene title

R1 : Average of lung tumors (including squamous cell carcinomas, adenocarcinomas, small cell carcinomas, granulomatous and carcinoid tumors) divided by the average of normal lung samples

R2: Average of non-malignant lung disease samples (including bronchitis, emphysema, fibrosis, atelectasiε, asthma) divided by the average of normal lung samples

Pkey ExAccn UnigenelD Unigene Title R1 R2

408562 AI436323 Hs.31141 Homo εapiens mRNA for KIAA1568 protein, 1.00 230.00

409031 AA376836 Hs.76728 ESTs 1.00 128.00

412372 R65998 Hs.285243 hypothetical protein FLJ22029 1.00 173.00

415910 U20350 Hs.78913 chemokine (C-X3-C) receptor 1 1.00 145.00

417511 AL049176 Hs.82223 chordin-like 1.00 179.00

418819 AA228776 Hs.191721 ESTs 1.00 140.00

422060 R20893 Hs.325823 ESTs, Moderately similar to ALU5_HUMAN A 1.00 156.00

424585 AA464840 Hs.131987 ESTs 1.00 167.00

426753 T89832 Hs.170278 ESTs 1.00 141.00

429496 AA453800 Hs.192793 ESTs 1.00 138.00

430719 AA488988 Hs.293796 ESTs 1.00 133.00

431089 BE041395 ESTs, Weakly similar to unknown protein 23.32 941.00

431385 BE178536 Hs.11090 membrane-spanning 4-domaiπs, subfamily A 1.00 157.00

431728 NM_007351 Hs.268107 multimerin 1.00 157.00

436532 AA721522 gb:nv54h12.r1 NCI CGAP_Ew1 Homo εapienε 1.00 218.00

437960 AI669586 Hs.222194 ESTs 1.00 147.00

438202 AW169287 Hs.22588 ESTs 1.00 141.00

441499 AW298235 Hs.101689 ESTs 1.00 167.00

444513 AL120214 Hs.7117 glutamate receptor, ionotropic, AMPA 1 1.00 151.00

448253 H25899 Hs.201591 ESTs 1.00 141.00

453636 R67837 Hs.169872 ESTs 1.00 116.00

458332 AI000341 Hs.220491 ESTs 1.00 192.00

459587 AA031956 gb:zk15e04.s1 Soares_pregnant_uterus_NbH 1.00 154.00

TABLE 13B

Pkey: Unique Eos probeset identifier number

CAT number: Gene cluster number Accession: Genbank accession numbers

Pkey CAT Number Accession

431089 327825 1 BE041395 AA491826AA621946 AA715980 AA666102

436532 421802.1 AA721522 AW975443 T93070

TABLE 13C

Pkey: Unique number corresponding to an Eos probeset Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. "Dunham I. et al." refers to the publication entitled "The DNA sequence of human chromoεome 22." Dunham I. et at, Nature (1999) 402:489495.

Strand: Indicates DNA strand from which exons were predicted. NLposition: Indicates nucleotide positions of predicted exons.

Pkey Ref Strand NLposition

402075 8117407 Plus 121907-122035,122804-122921,124019-124161,124455-124610,125672-126076 TABLE 14A Preferred Utility and Subcellular Localization for Potential Lung Disease Targets

Table 14A shows the subcellular localization and preferred utility for the geneε appearing in Tables 9A and 10A mAb symbolizes monoclonal antibody, diag symbolizes diagnostic, s m symbolizes small molecule, and CTL symbolizes cytotoxic lymphocytic ligand These genes were selected from 59680 probesets on the Eos/Affymetnx Hu03 Genechip array

Table 14B show the accesεion numbers for those Pkey's lacking UnigenelD's for table 14A For each probeset we have listed the gene cluster number from which the oligonucleotides were designed Gene clusters were compiled using sequences deπved from Genbank ESTs and mRNAs These sequences were clustered based on sequence similanty using Clustering and Alignment Tools (DoubleTwist, Oakland California) The Genbank accession numbers for sequences comprising each cluster are listed in the "Accession" column

Table 14C show the genomic positioning for those Pkey's lacking Unigene IDs and accession numbers in table 14A For each predicted exon, we have listed the genomic sequence source used for prediction Nucleotide locations of each predicted exon are also listed

Pkey Unique Eos probeset identifier number

ExAccn Exemplar Accession number, Genbank accession number

UnigenelD Unigene number

Unigene Title Unigene gene title

Pref Utility Preferred Utility

Pred Loc Predicted subcellular localization

Pkey ExAccn UnigenelD Unigene Title Pref Utility Pred Loc

400289 X07820 Hs2258 matrix metalloproteinase 10 (stromelysin mAb & diag & s m extracellular

400303 AA242758 Hs 79136 LIV-1 protein, estrogen regulated mAb plasma membrane

402075 ENSP00000251056* Plasma membrane calcium mAb & diag secreted

407811 AW190902 Hs 40098 cysteine knot superfamily 1 , BMP antagon diag secreted

408243 Y00787 Hs 624 interleukin 8 diag secreted

408790 AW580227 Hs 47860 neurotrophio tyrosine kinase, receptor, mAb & s m plasma membrane

408908 BE296227 Hs 250822 seπne/threonine kinase 15 s m cytoplasm

409041 AB033025 Hs 50081 Hypothetical protein, XP_051860 (KIAA119 CTL & diag secreted

409103 AF251237 Hs 112208 XAGE-1 protein CTL nuclear

409420 Z15008 Hs 54451 laminin, gamma 2 (nicem (100kD), kalim diag secreted

409632 W74001 Hs 55279 serine (or cysteine) proteinase inhibito diag secreted

409757 NM 001898 Hs 123114 cystatm SN diag extracellular

409893 AW247090 Hs 57101 minichromosome maintenance deficient (S CTL nuclear

409956 AW103364 Hs 727 mhibin, beta A (activm A, activm AB a diag extracellular

410001 AB041036 Hs 57771 kallιkreιn 11 diag extracellular

410407 X66839 Hs 63287 carbonic anhydrase IX mAb & ε m plasma membrane

410418 D31382 Hs 63325 transmembrane protease, senne 4 mAb & diag & ε m plasma membrane

412140 AA219691 Hs 73625 RAB6 interacting, kinesin-like (rabkines s m

412719 AW016610 Hs 816 ESTs sm nuclear

414774 X02419 Hs 77274 plasmmogen activator, urokinase diag extracellular

414883 AA926960 CDC28 protein kinase 1 s m

415138 C18356 Hs 295944 tissue factor pathway inhibitor 2 CTL & diag extracellular

415669 NM 005025 Hs 78589 serine (or cysteine) proteinase inhibito mAb & diag & s m secreted

415817 U88967 Hs 78867 protein tyrosine phosphatase, receptor-t mAb & s m plasma membrane

416658 U03272 Hs 79432 fibrillin 2 (congenital contractural ara diag extracellular

417034 NM 006183 Hs 80962 neurotensin diag extracellular

417079 U65590 Hs 81134 interleukin 1 receptor antagonist diag extracellular

417308 H60720 Hs 81892 KIAA0101 gene product s m mitochondrial

417389 BE260964 Hs 82045 midkine (neunte growth-promoting factor mAb & diag secreted

417433 BE270266 Hs 82128 5T4 oncofetal trophoblast glycoprotem mAb plasma membrane

417933 X02308 Hs 82962 thymidylate synthetase s m endoplasmic reticulum

418478 U38945 Hs 1174 cyclm dependent kinase inhibitor 2A (me s m cytoplasm

418506 AA084248 Hs 85339 G protein coupled receptor 39 mAb & ε m plasma membrane

418678 NM 001327 Hs 167379 cancer/testis antigen (NY-ESO-1) CTL cytoplasmic

419121 AA374372 Hs 89626 parathyroid hormone like hormone diag secreted

419171 NM 002846 Hs 89655 protein tyrosine phosphatase, receptor t mAb & ε m plasma membrane

419183 U60669 Hs 89663 cytochrome P450, subfamily XXIV (vitamin CTL&s m mitochondrial

419216 AU076718 Hs 164021 small inducible cytokine subfamily B (Cy diag secreted

419235 AW470411 Hs 288433 neurotnmin mAb & diag plasma membrane

419452 U33635 Hs 90572 PTK7 protein tyrosine kinase 7 mAb & s m plasma membrane

419556 U29615 Hs 91093 chit ase 1 (chitot oεidaεe) mAb & diag extracellular*

420610 AI683183 Hs 99348 distal-less homeo box 5 CTL nuclear

421110 AJ250717 Hs 1355 cathepsm E εm & diag extracellular

421379 Y15221 Hs 103982 small inducible cytokine subfamily B (Cy diag secreted

421474 U76362 Hs 104637 solute carrier family 1 (glutamate trans mAb & s m plasma membrane

421552 AF026692 Hs 105700 secreted fnzzled-related protein 4 diag secreted

421753 BE314828 Hs 107911 ATP binding cassette, sub family B (MDR/ mAb & ε m plasma membrane

421817 AF146074 Hs 108660 ATP-binding cassette, sub-family C (CFTR mAb & 8 m plasma membrane

422109 S73265 Hs 1473 gastnn releasing peptide diag secreted

422158 L10343 Hs 112341 proteaεe inhibitor 3, skm-deπved (SKAL diag secreted

422282 AF019225 Hs 114309 apolipoprotein L diag secreted

422283 AW411307 Hs 114311 CDC45 (cell division cycle 45, S cerevis s m nuclear

422424 AI186431 Hs 296638 prostate differentiation factor diag extracellular

422765 AW409701 Hs 1578 bacutoviral IAP repeat-containing 5 (sur s m cytoplasm

422809 AK001379 Hs 121028 hypothetical protein FLJ10549 s m nuclear

422867 L32137 Hs 1584 cartilage oligomeπo matrix protein (pse diag extracellular

422956 BE545072 Hs 122579 ECT2 protein (Epithelial cell transformi CTL & s m

423634 AW959908 Hs 1690 hepann-bindmg growth factor binding pr diag

423673 BE003054 Hs 1695 matnx metalloproteinase 12 (macrophage mAb & diag & s m εecreted

423961 D13666 Hs 136348 peπostin (OSF-2os) mAb & diag extracellular

424046 AF027866 Hs 138202 senne (orcysteme) proteinase inhibito diag εecreted

424381 AA285249 Hs 146329 protein kinase Chk2 s m nuclear 424502 AF242388 Hs.149585 lengsin s.m. cytoplasmic

424503 NM 002205 Hs.149609 integrin, alpha 5 (fibronectin receptor, mAb & ε.m. plasma membrane

424687 J05070 Hs.151738 matrix metalloproteinase 9 (gelatinaεe B diag extracellular

425247 NM 005940 Hs.155324 matrix metalloproteinase 11 (stromelysin mAb & diag & s.m. secreted

425322 U63630 Hs.155637 protein kinase, DNA-activated, catalytic s.m. cytoplasmic

425650 NM 001944 Hs.1925 desmoglein 3 (pemphigus vulgaris antigen mAb plasma membrane

425734 AF056209 Hs.159396 peptidylglycine alpha-amidating monooxyg s.m.

425776 U25128 Hs.159499 parathyroid hormone receptor 2 mAb & diag plasma membrane

425852 AK001504 Hs.159651 death receptor 6, TNF superfamily member mAb & ε.m. plasma membrane

426215 AW963419 Hs.155223 stanniocalcin 2 mAb & diag secreted

426427 M86699 Hs.169840 TTK protein kinase CTL & ε.m. nuclear

426514 BE616633 Hs.170195 bone morphogenetic protein 7 (osteogenic mAb & diag secreted

427335 AA448542 Hs.251677 G antigen 7B CTL cytoplasmic

427747 AW411425 Hs.180655 serine/threonine kinaεe 12 ε.m. cytoplasmic

428242 H55709 Hs.2250 leukemia inhibitory factor (cholinergic diag

428330 L22524 Hs.2256 matrix metalloproteinase 7 (matrilysin, mAb & diag & ε.m. extracellular

428450 NM 014791 Hs.184339 KIAA0175 gene product s.m. nuclear

428479 Y00272 Hs.334562 cell division cycle 2, G1 to S and G2 to s.m. nuclear

428484 AF104032 Hs.184601 solute carrier family 7 (cationic amino mAb & s.m. plasma membrane

428664 AK001666 Hs.189095 similar to SALL1 (sal (Drosophila)-like CTL & s.m. nuclear

428698 AA852773 Hs.334838 KIAA1866 protein mAb

428748 AW593206 Hs.98785 Ksp37 protein diag extracellular

428758 AA433988 Hs.98502 CA125 antigen; mucin 16 diag mitochodria*

428969 AF120274 Hs.194689 artemin diag extracellular

429211 AF052693 Hs.198249 gap junction protein, beta 5 (connexin 3 mAb & s.m. plasma membrane

429263 AA019004 Hε.198396 ATP-binding cassette, sub-family A (ABC1 mAb & s.m. plasma membrane

429547 AW009166 Hs.99376 ESTs diag secreted

429610 AB024937 Hs.211092 LUNX protein; PLUNC (palate lung and nas mAb & diag secreted

429903 AL134197 Hs.93597 cyclin-dependent kinase 5, regulatory su s.m.

430486 BE062109 Hs.241551 chloride channel, calcium activated, fam AbS s.m. plasma membrane

431462 AW583672 Hs.256311 granin-like neuroendocrine peptide precu diag extracellular

431515 NM.012152 Hs.258583 endothelial differentiation, lysophospha mAb & s.m. plasma membrane

431846 BE019924 Hs.271580 uroplakiπ 1B mAb & diag plasma membrane

431958 X63629 Hs.2877 cadherin 3, type 1, P-cadherin (placenta mAb & diag plasma membrane

432201 AI538613 Hs.298241 Transmembrane proteaεe, εerine 3 mAb & diag & s.m. plasma membrane

433001 AF217513 Hs.279905 clone HQ0310 PRO0310p1 s.m. nuclear

435505 AF200492 Hs.211238 interleukin-1 homolog 1 diag secreted

436481' AA379597 Hs.5199 HSPC150 protein similar to ubiquitin-con s.m.

437016 AU076916 Hs.5398 guanine monphosphate synthetase s.m. cytoplasm

437044 AL035864 Hs.69517 differentially expresεed in Faπcoπi'ε an CTL ER

437789 AI581344 Hs.127812 ESTs, Weakly similar to T17330 hypotheti CTL nuclear

437852 BE001836 Hs.256897 ESTs, Weakly slmilarto dJ365012.1 [H.sa mAb & s.m. plasma membrane

439223 AW238299 Hs.250618 UL16 binding protein 2 mAb plasma membrane

439477 W69813 Hs.58042 ESTs, Moderately similar to GFR3_HUMAN G mAb & s.m.

439606 W79123 Hs.58561 G protein-coupled receptor 87 mAb & s.m. plasma membrane

439738 BE246502 Hs.9598 sema domain, immunoglobulin domain (Ig), mAb & s.m. plasma membrane

440006 AK000517 Hs.6844 NALP2 protein; PYRIN-Contaiπing APAF1-H s.m. nuclear

441362 BE614410 Hs.23044 RAD51 (S. cerevisiae) homolog (E coli Re s.m.

442117 AW664964 Hs.128899 ESTs; hypothetical protein for IMAGE:447 mAb & s.m. plasma membrane

443247 BE614387 Hs.333893 c-Myc target JP01 CTL extracellular*

443426 AF098158 Hs.9329 chromosome 20 open reading frame 1 CTL

443859 NM.013409 Hs.9914 follistatin diag extracellular

444006 BE395085 Hs.10086 type I tranεmembrane protein Fn14 mAb plasma membrane

444371 BE540274 Hs.239 forkhead box Ml s.m. nuclear

444381 BE387335 Hs.283713 ESTε, Weakly similar to S64054 hypotheti diag secreted

444781 NM_014400 Hs.11950 GPI-anchored metastasis-associated prate mAb & diag plasma membrane

445537 AJ245671 Hs.12844 EGF-like-domain, multiple 6 mAb & diag εecreted

446619 AU076643 Hs.313 secreted phosphoprotein 1 (osteopontin, diag εecreted

446921 AB012113 Hε.16530 email inducible cytokine subfamily A (Cy diag extracellular

447033 AI357412 Hs.157601 ESTs CTL & diag secreted

447342 AI199268 Hs.19322 Homo sapiens, Similar to RIKEN cDNA 2010 CTL

448243 AW369771 Hs.52620 integrin, beta 8 mAb & ε.m. - plasma membrane

448844 AI581519 Hs.177164 ESTs mAb & s.m.

449048 Z45051 Hs.22920 similar to S68401 (cattle) glucose indue mAb plasma membrane

449722 BE280074 Hs.23960 cyclin B1 s.m. cytoplasm

450001 NM 001044 Hs.406 solute carrier family 6 (neurotransmitte mAb & s.m. plasma membrane

450375 AA009647 a disintegrin and metalloproteinase doma mAb & diag & s.m. plasma membrane

450701 H39960 Hs.288467 hypothetical protein XP_098151 (leucine- mAb & diag plasma membrane

450983 AA305384 Hs.25740 ER01 (S. cerevisiae)-like diag secreted

451668 Z43948 Hs.326444 cartilage acidic protein 1 mAb & diag plasma membrane

452281 T93500 Hs.28792 Homo sapiens cDNA FLJ11041 fis, clone PL diag

452401 NM_007115 Hs.29352 tumor necrosiε factor, alpha-induced pro diag extracellular

452747 BE153855 Hs.61460 Ig superfamily receptor LNIR mAb plasma membrane

452838 U65011 Hs.30743 preferentially expresεed antigen in mela CTL nuclear

453968 AA847843 Hs.62711 High mobility group (nonhiεtone chromoso CTL & s.m. nuclear

457489 AI693815 Hs.127179 cryptic gene diag secreted

TABLE 14B

Pkey: Unique Eos probeset identifier number

CAT number: Gene cluster number Accession: Genbank accession numbers

Pkey CAT Number Accesεion 414883 15024.1 AA926960 AA926959 W76521 W24270 W21526 AA037172 BE267636 H83186 AA469909 N86396 AA001348 BE535736 AA081745 BE566245 AA082436 H72525 H77575 N49786 W80565 H78746 BE569085 W04339 R98127 T55938 BE279271 AW960304 T29812 AA476873 BE297387 AA292753 AA177048 NM.001826 X54941 BE314366 AA908783 AI719075 BE270172 BE269819 AA889955 AI204630 W25243 AI935150 AA872039 W72395 T99630 AI422691 H98460 N31428 BE255916 H03265 AI857576 AA776920 AA910644 AA459522 AA293140 AW514667 R75953 AW662396 AA662522 AI865147 AI423153 AW262230 AA584410 AA583187 AW024595 AW069734 AI828996 AA282997 AA876046 AW613002 AA527373 AW972459 AI831360 AA621337 AA100926 AA772418 AA594628 AI033892 W95096 AI034317 AA398727 AI085031 N95210 AI459432 AI041437 AA932124 AA627684 AA935829 AI004827 AI423513 AI094597 H42079 R54703 AI630359 AA617681 AA978045 AA643280 W44561 AI991988 AI537692 AI090262 AA740817 AI312104 AI911822 AA416871 AI185409 AA129784 AA701623 AI075239 AI139549 AA633648 AI339996 AI336880 AA399239 AI078708 AI085351 AI362835 AI346618 AI146955 AI989380 AI348243 N92892 AA765850 AI494230 AI278887 AA962596 AI492600 W80435 AA001979 R97424 AH 29015 N24127 AA157451 AA235549 AA459292 AA037114 AA129785 AI494211 AW059601 AW8B6710 R92790 N59755 A1361128 AW5B9407 H47725 H97534 H48076 H48450T99631 AW300758 H03431 R76789 AA954344 H77576 R96823 AI457100 N92845 N49682 H42038 BE220698 BE220715 H99552 AA701624 N74173 R54704 H79520 H72923 H03266 BE261919 AA769633 AA480310 AA507454 AA910586 AI203723 AW104725 W25611 W25071 T88980 H03513 T77589 R99156 W95095 R97470 AA702275 T77551 AA911952 H82956 N83673 AA283672

450375 83327.1 AA009647 AA131254 AA374293 AW954405 H04410 AW606284 AA151166 BE157467 BE157601 H04384 W46291 AW663674 H04021 H01532 AA190993 H03231 H59605 H01642 AA852876AA113758 AA626915 AA746952 AI161014 AA099554 R69067

TABLE 14C

Pkey: Unique number corresponding to an Eos probeset Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. "Dunham I. et al." refers to the publication entitled "The DNA εequence of human chromoεome 22." Dunham I. et at, Nature (1999) 402:489495.

Strand: Indicates DNA strand from which exonε were predicted. NLpoεition: Indicates nucleotide positions of predicted exons.

Pkey Ref Strand NLposition

402075 8117407 Plus 121907-122035,122804-122921,124019-124161,124455-124610,125672-126076

TABLE 15A Information for all sequences in Table 16

Table 15A shows the Seq ID No, Pkey, ExAccn, UnigenelD, and Unigene Title for all ofthe sequences in Table 16

Table 15B show the accession numbers for those Pkey's lacking UnigenelD's for table 15A For each probeset we have listed the gene cluster number from which the oligonucleotideε were deεigned Gene clusters were compiled using sequences deπved from Genbank ESTs and mRNAs These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland California) The Genbank accession numbers for sequenceε comprising each cluster are listed in the "Accesεion" column

Table 15C εhow the genomic positioning for those Pkey's lacking Unigene ID's and accession numbers in table 15A For each predicted exon, we have listed the genomic sequence source used for prediction Nucleotide locations of each predicted exon are also listed

Seq ID No Sequence ID number

Pkey Unique Eos probeset identifier number

ExAccn Exemplar Accesεion number, Genbank accession number

UnigenelD Unigene number

Unigene Title Unigene gene title

Seq ID No Pkey ExAccn UnigenelD Unigene Title

Seq ID No 1 & 2 410407 X66839 Hs 63287 carbonic anhydrase IX

Seq ID No 38.4 412719 AW016610 Hs 816 ESTs

Seq ID No 5 & 6 417034 NM 006183 Hs 80962 neurotensm

Seq ID No 7 & 8 430486 BE062109 Hs 241551 chloride channel calcium activated, fam

Seq ID No 9 & 10 407788 BE514982 Hs 38991 S100 calcium binding protein A2

Seq ID No 11 & 12 407788 BE514982 Hs 38991 S100 calcium binding protein A2

Seq ID No 138.14 407788 BE514982 Hs 38991 S100 calcium binding protein A2

Seq ID No 15 & 16 407788 BE514982 Hs 38991 S100 calcium binding protein A2

Seq ID No 17 & 18 439285 AL133916 hypothetical protein FLJ20093

Seq ID No 19 & 20 413753 U17760 Hs 75517 laminin, beta 3 (nicem (125kD), kalin

Seq ID No 21 & 22 120486 AW368377 Hs 137569 tumor protein 63 kDa with strong homolog

Seq ID No 23 & 24 425650 NM 001944 Hs 1925 desmoglein 3 (pemphigus vulgaπs antigen

Seq ID No 258.26 412140 AA219691 Hs 73625 RABΘ interacting kinesm like (rabkines

Seq ID No 27 & 28 423673 BE003054 Hs 1695 matnx metalloproteinase 12 (macrophage

Seq ID No 29 & 30 452838 U65011 Hs 30743 preferentially expressed antigen in mela

Seq ID No 31 & 32 418663 AK001100 Hs 41690 desmocollin 3

Seq ID No 33 & 34 418663 AK001100 Hs 41690 deεmocolliπ 3

Seq ID No 35 & 36 409632 W74001 Hs 55279 serine (orcysteme) proteinase inhibito

Seq ID No 37 & 38 429610 AB024937 Hs 211092 LUNX protein, PLUNC (palate lung and nas

Seq ID No 39 & 40 406690 M29540 Hs 220529 carcinoembryonic antigen-related cell ad

Seq ID No 41 & 42 431846 BE019924 Hs 271580 uroplakin 1B

Seq ID No 43 & 44 418830 BE513731 Hs 88959 hypothetical protein MGC4816

Seq ID No 45 & 46 424098 AF077374 Hs 139322 small proline πch protein 3

Seq ID No 47 & 48 443648 AI085377 Hs 143610 ESTs

Seq ID No 49 311034 BE567130 Hs 311389 ESTs, Highly similar to NKGD_HUMAN NKG2-

Seq ID No 50 & 51 408522 AI541214 Hs 46320 Small proline rich protein SPRK [human,

Seq ID No 52 & 53 422158 L10343 Hs 112341 protease inhibitor 3, skiπ-deπved (SKAL

Seq ID No 54 & 55 435505 AF200492 Hs 211238 ιnterleukιn-1 homolog 1

Seq ID No 56 & 57 417366 BE185289 Hs 1076 small praline rich protein 1B (cormfin)

Seq ID No 58 & 59 431958 X63629 Hs2877 cadheπn 3, type 1, P-cadheπn (placenta

Seq ID No 60 & 61 441020 W79283 Hs 35962 ESTε

Seq ID No 62 & 63 423217 NM 000094 Hε 1640 collagen, type VII, alpha 1 (epidermolys

Seq ID No 64& 65 429538 BE182592 Hs 11261 small proline rich protein 2A

Seq ID No 66 & 67 448733 NM 005629 Hs 187958 solute carrier family 6 (neurotransmitte

Seq ID No 68 & 69 444371 BE540274 Hs 239 forkhead box M1

Seq ID No 708.71 444371 BE540274 Hε 239 forkhead box Ml

Seq ID No 72 & 73 444371 BE540274 Hs 239 forkhead box M1

Seq ID No 74 & 75 422168 AA586894 Hs 112408 S100 calcium binding protein A7 (psoπas

Seq ID No 76 & 77 422168 AA586894 Hs 112408 S100 calcium binding protein A7 (psoπas

Seq ID No 78 & 79 429259 AA420450 Hs 292911 Plakophilin

Seq ID No 80 & 81 426440 BE382756 Hs 169902 solute carrier family 2 (facilitated glu

Seq ID No 82 & 83 437044 AL035864 Hs 69517 differentially expressed in Fancom s an

Seq ID No 84 & 85 423662 AK001035 Hs 130881 B cell CtUlymphoma 11A (zinc finger pro

Seq ID No 86 & 87 428484 AF104032 Hε 184601 solute carrier family 7 (cationic am o

Seq ID No 88 & 89 429211 AF052693 Hε 198249 gap junction protein, beta 5 (connexin 3

Seq ID No 90 & 91 417389 BE260964 Hs 82045 midk e (neuπte growth-promoting factor

Seq ID No 92493 423634 AW959908 Hs 1690 hepaππ-biπding growth factor binding pr

Seq ID No 94 & 95 417515 L24203 Hs 82237 ataxia-telangiectasia group D associated

Seq ID No 96 & 97 441362 BE614410 Hs 23044 RAD51 (S cerevisiae) homolog (E coli Re

Seq ID No 98 & 99 425322 U63630 Hs 155637 protein kinase, DNA activated, catalytic

Seq ID No 100 & 101 449003 X76342 Hs 389 alcohol dehydrogenase 7 (class IV), mu o

Seq ID No 102 & 103 431009 BE149762 Hs 48956 gap junction protein, beta 6 (connexin 3

Seq ID No 104 & 105 409103 AF251237 Hs 112208 XAGE-1 protein

Seq ID No 106 & 107 417542 J04129 Hs 82269 pragestagen associated endometrial prote

Seq ID No 108 & 109 428471 X57348 Hs 184510 stratifin

Seq ID No 110& 111 418004 U37519 Hs 87539 aldehyde dehydrogenase 3 family, member

Seq ID No 1128. 113 414761 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2

Seq ID No 1148, 115 418203 X54942 Hs B3758 CDC28 protein kinase 2

Seq ID No 116 447343 AA256641 Hs 236894 ESTs, Highly similar to S02392 alpha-2-m

Seq ID No 1178.118 437016 AU076916 Hs 5398 guanine monphosphate synthetase

Seq ID No 119 & 120 449230 BE613348 Hs 211579 melanoma cell adhesion molecule

Seq ID No 121 & 122 446989 AK001898 Hs 16740 hypothetical protein FLJ 11036

Seq ID No 1238, 124 457819 AA057484 Hs 35406 ESTs, Highly similar to unnamed protein

Seq ID No 1258. 126 424687 J05070 Hs 151738 matnx metalloproteinase 9 (gelatmase B Seq ID No: 1278. 128 414430 AI346201 Hε.76118 ubiquitin carboxyl-terminal esterase L1

Seq ID No: 1298, 130 418462 BE001596 Hε.85266 integrin, beta 4

Seq ID No: 131 & 132 100668 L05424 Hs.169610 CD44 antigen (homing function and Indian

Seq ID No: 1338. 134 458933 AI638429 Hs.24763 RAN binding protein 1

Seq ID No: 1358.136 418478 U38945 Hs.1174 cyclin-dependent kinase inhibitor 2A (me

Seq ID No: 1378. 138 418478 U38945 Hs.1174 cyclin-dependent kinase inhibitor 2A (me

Seq ID No: 139 & 140 418478 U38945 Hs.1174 cyclin-dependent kinase inhibitor 2A (me

Seq ID No: 141 & 142 418478 U38945 Hs.1174 cyclin-dependent kinase inhibitor 2A (me

Seq ID No: 143 & 144 446269 AW263155 Hs.14559 hypothetical protein FLJ 10540

Seq ID No: 145 & 146 422765 AW409701 Hs.1578 baculoviral IAP repeat-containing 5 (sur

Seq ID No: 1478. 148 436481 AA379597 Hs.5199 HSPC150 protein similar to ubiquitin-con

Seq ID No: 149 & 150 440325 NM 003812 Hs.7164 a disintegrin and metalloproteinase doma

Seq ID No: 151 & 152 439606 W79123 Hs.58561 G protein-coupled receptor 87

Seq ID No: 153 & 154 453884 AA355925 Hs.36232 KIAA0186 gene product

Seq ID No: 1558, 156 453884 AA355925 Hε.36232 KIAA0186 gene product

Seq ID No: 1578, 158 453884 AA355925 Hs.36232 KIAA0186 gene product

Seq ID No: 159 & 160 453884 AA355925 Hs.36232 KIAA0186 gene product

Seq ID No: 161 & 162 404877 NM_005365:Homo sapiens melanoma antigen,

Seq ID No: 1638, 164 413129 AF292100 Hs.104613 RP42 homolog

Seq ID No: 165 & 166 413281 AA861271 Hs.222024 transcription factor BMAL2

Seq lD No: 167 & 168 444781 NM 014400 Hs.11950 GPI-anchored metastasis-associated prate

Seq ID No: 169 & 170 416819 U77735 Hs.80205 pim-2 oncogene

Seq ID No: 171 & 172 451320 AW118072 diacylglycerol kinase, zeta (104kD)

Seq ID No; 1738, 174 418543 NM 005329 Hs.85962 hyaluronan syπthase 3

Seq ID No: 175 & 176 454034 NM 000691 Hs.575 aldehyde dehydrogenase 3 family, member

Seq ID No: 177 & 178 425397 J04088 Hs.156346 topoisomerase (DNA) II alpha (170kD)

Seq ID No: 1798. 180 415817 U88967 Hs.78867 protein tyrosine phosphatase, receptor-t

Seq ID No: 181 & 182 415817 U88967 Hs.78867 protein tyrosine phosphatase, receptor-t

Seq ID No: 183 & 184 415817 U88967 Hs.78867 protein tyrosine phosphatase, receptor-t

Seq ID No: 1858. 186 415817 U88967 Hs.78867 protein tyrosine phosphatase, receptor-t

Seq ID No: 187 & 188 415817 U88967 Hs.78867 protein tyrosine phosphatase, receptor-t

Seq ID No: 189 & 190 419121 AA374372 Hs.89626 parathyroid hormone-like hormone

Seq ID No: 191 8. 192 448993 AI471630 Hs.8127 KIAA0144 gene product

Seq ID No: 1938. 194 421817 AF146074 Hs.108660 ATP-binding casεette, sub-family C (CFTR

Seq ID No: 1958. 196 430393 BE185030 Hs.241305 estrogen-reεponsive B box protein

Seq ID No: 197 & 198 425057 AA826434 Hs.1619 achaete-scute complex (Drosophila) homol

Seq ID No: 199 & 200 420462 AF050147 Hs.97932 chondromodulin I precursor

Seq ID No: 201 & 202 102963 X02404 Hs.274534 calcitonin-related polypeptide, beta

Seq ID No: 2038, 204 100576 X00356 Hs.37058 calcitonin/calcitonin-related polypeptid

Seq ID No: 205 & 206 101175 U82671 Hε.36980 melanoma antigen, family A, 2

Seq ID No: 2078, 208 429038 AL023513 Hs.194766 seizure related gene 6 (mouse)-like

Seq ID No: 209 & 210 418678 NM 001327 Hs.167379 cancer/testiε antigen (NY-ESO-1)

Seq ID No: 211 8, 212 418678 NM 001327 Hs.167379 cancer/testis antigen (NY-ESO-1)

Seq ID No: 213 & 214 131927 AJ003112 Hs.34780 doublecortex; lissencephaly, X-liπked (d

Seq ID No: 215 & 216 428182 BE386042 Hs.293317 ESTs, Weakly similar to GGC1.HUMAN G ANT

Seq ID No: 217 & 218 427335 AA448542 Hs.251677 G antigen 7B

Seq ID No: 2198.220 409420 Z15008 Hs.54451 laminin, gamma 2 (nicein (100kD), kalini

Seq ID No: 221 & 222 114346 AL137256 Hs.130489 ATPase, aminophospholipid transporter-li

Seq ID No: 223 & 224 438956 W00847 Hs.135056 Human DNA sequence from clone RP5-850E9

Seq ID No: 225 & 226 404440 NM_021048:Homo sapienε melanoma antigen,

Seq ID No: 2278.228 415669 NM 005025 Hε.78589 serine (or cysteine) proteinase inhibito

Seq ID No: 2298.230 103312 Y12642 Hs.3185 lysosomal

Seq ID No: 231 & 232 320843 BE069288 Hs.34744 Homo sapiens mRNA; cDNA DKFZp547C136 (fr

Seq ID No: 233 429065 AI753247 Hs.29643 Homo sapienε cDNA FLJ13103 fis, clone NT

Seq ID No: 234 & 235 446102 AW168067 Hε.317694 ESTs

Seq ID No: 2368.237 330495 U47924 Hs.71642 guanine nucleotide binding protein (G pr

Seq ID No: 238 413573 AI733859 Hs.149089 ESTs

Seq ID No: 239 & 240 428479 Y00272 Hs.334562 cell division cycle 2, G1 to S and G2 to

Seq ID No: 241 & 242 428479 Y00272 Hs.334562 cell division cycle 2, G1 to S and G2 to

Seq ID No: 2438, 244 332180 AF134160 Hs.7327 claudin 1

Seq ID No: 245 437915 AI637993 Hs.202312 Homo sapiens clone N11 NTera2D1 teratoca

Seq ID No: 2468.247 441553 AA281219 Hs.121296 ESTs

Seq ID No: 248 & 249 331692 AI683487 Hs.152213 wiπglesε-type MMTV integration site fa i

Seq ID No: 250 & 251 429413 NM 014058 Hs.201877 DESC1 protein

Seq ID No: 252 & 253 422283 AW411307 Hs.114311 CDC45 (cell division cycle 45, S.cerevis

Seq ID No: 254 & 255 448357 N20169 Hs.108923 RAB38, member RAS oncogene family

Seq ID No: 256 & 257 446292 AF081497 Hs.279682 Rh type C glycoprotein

Seq ID No: 258 & 259 416209 AA236776 Hs.79078 MAD2 (mitotic arrest deficient, yeast, h

Seq ID No: 260 & 261 453922 AF053306 Hs.36708 budding uninhibited by benzi idazoles 1

Seq ID No: 262 & 263 424046 AF027866 Hε.138202 serine (or cysteine) proteinase inhibito

Seq ID No: 264 & 265 439223 AW238299 Hs.250618 UL16 binding protein 2

Seq ID No: 266 & 267 429228 AI553633 Hs.326447 ESTs

Seq ID No: 268 & 269 409757 NM 001898 Hε.123114 cystatin SN

Seq ID No: 270 & 271 411089 AA456454 Hε.214291 cell division cycle 2-like 1 (PITSLRE pr

Seq ID No: 2728, 273 436511 AA721252 Hs.291502 ESTε

Seq ID No: 274 & 275 428969 AF120274 Hs.194689 artemin

Seq ID No: 276 & 277 428969 AF120274 Hε.194689 artemiπ

Seq ID No: 278 & 279 428969 AF120274 Hs.194689 artemin

Seq ID No: 280 & 281 428969 AF120274 Hs.194689 artemin

Seq ID No: 282 407137 T97307 gb:ye53h05.ε1 Soares fetal liver spleen

Seq ID No: 283 & 284 412723 AA648459 Hs.335951 hypothetical protein AF301222

Seq ID No: 2858.286 450701 H39960 Hs.288467 hypothetical protein XP.09B151 (leucine-

Seq ID No: 287 & 288 405770 NM_002362:Homo sapiens melanoma antigen,

Seq ID No: 289 & 290 439453 BE264974 Hs.6566 thyroid hormone receptor interactor 13

Seq ID No: 291 & 292 414774 X02419 Hs.77274 plas lnogen activator, uroklnase Seq ID No : 293 & 294 424629 M90656 Hs.151393 glutamate-cysteine ligase, catalytic sub Seq ID No (: 2954296 437789 AI581344 Hs.127812 ESTs, Weakly similar to T17330 hypotheti Seq ID No: 297 & 298 437789 AI581344 Hs.127812 ESTs, Weakly similar to T17330 hypotheti Seq ID No: 299 & 300 437789 AI581344 Hs.127812 ESTs, Weakly similar to T17330 hypotheti Seq ID No: 301 8, 302 437789 AI581344 Hs.127812 ESTs, Weakly similar to T17330 hypotheti Seq ID No: 3038, 304 437789 AI581344 Hs.127812 ESTs, Weakly slmilarto T17330 hypotheti Seq ID No: 305 & 306 453968 AA847843 Hs.62711 High mobility group (nonhistone chromoso Seq ID No: 3078.308 403478 NM_022342:Homo sapiens kiπesin protein 9 Seq ID No: 309 441525 AW241867 Hs.127728 ESTs Seq ID No: 3108, 311 434105 AW952124 Hs.13094 presenilins associated rhomboid-like pro Seq ID No: 3128, 313 428810 AF068236 Hs.193788 nitric oxide synthase 2A (inducible, hep Seq ID No: 3148, 315 413691 AB023173 Hs.75478 ATPase, Class VI, type 11B Seq ID No: 3168, 317 423934 U89995 Hs.159234 forkhead box E1 (thyroid transcription f Seq ID No: 3188, 319 409228 R16811 Hs.22010 ESTs, Weakly similar to 2109260A B cell Seq ID No: 320 & 321 425734 AF056209 Hs.159396 peptidylglycine alpha-amidating monooxyg Seq ID No: 3228, 323 413582 AW295647 Hs.71331 hypothetical protein MGC5350 Seq ID No: 3248, 325 438403 AA806607 Hs.292206 ESTs Seq ID No: 3268.327 403329 unnamed protein product [Homo sapienε] Seq ID No: 3288, 329 409893 AW247090 Hs.57101 minichromosome maintenance deficient (S. Seq ID No: 3308, 331 119073 BE245360 Hs.279477 v-ets erythroblastoεiε virus E26 oncogen Seq ID No: 332 & 333 113195 H83265 Hs.8881 ESTs, Weakly similar to S41044 chromosom Seq ID No: 3348, 335 102283 AW161552 Hs.83381 guanine nucleotide binding protein 11 Seq ID No: 3368, 337 101345 NM_005795 Hs.152175 calcitonin receptor-like Seq ID No: 338 & 339 103280 U84722 Hs.76206 cadherin 5, type 2, VE-cadherin (vascula Seq ID No: 3408, 341 102012 BE259035 Hs.118400 singed (DroεophilaJ-like (εea urchin fas Seq ID No: 3428, 343 105729 H46612 Hs.293815 Homo sapiens HSPC285 mRNA, partial eds Seq ID No: 3448, 345 134299 AW580939 Hs.97199 complement component C1q receptor Seq ID No: 3468, 347 412719 AW016610 Hs.816 ESTs Seq ID No: 3488, 349 422158 L10343 Hs.112341 protease inhibitor 3, skin-derived (SKAL Seq ID No: 3508, 351 128924 BE279383 Hs.26557 plakophilin 3 Seq ID No: 3528, 353 100486 T19006 Hs.10842 RAN, member RAS oncogene family Seq ID No: 3548, 355 419121 AA374372 Hs.89626 parathyroid hormone-like hormone Seq ID No: 3568, 357 409459 D86407 Hs.54481 low density lipoprotein receptor-related Seq ID No: 3588, 359 330493 M27826 endogenouε retroviral proteaεe Seq ID No: 3608.361 417866 AW067903 Hs.82772 collagen, type X!, alpha 1 Seq ID No: 3628, 363 418113 AI272141 Hs.83484 SRY (sex determining region Y)-box 4 Seq ID No: 3648, 365 437016 AU076916 Hs.5398 guanine monphosphate synthetase Seq ID No: 366 & 367 429612 AF062649 Hs.252587 pituitary tumor-transforming 1 Seq ID No: 3688, 369 440704 M69241 Hs.162 insulin-like growth factor binding prate Seq ID No: 370 & 371 431221 AA449015 Hs.286145 SRB7 (suppressor of RNA polymerase B, ye Seq ID No: 3728, 373 431565 AF161470 Hs.260622 butyrate-induced transcript 1 Seq ID No: 3748, 375 431565 AF161470 Hs.260622 butyrate-induced transcript 1 Seq ID No: 3768, 377 132354 BE185289 Hs.1076 small proline-rich protein 1B (co ifin) Seq ID No: 378 & 379 424441 X14850 Hs.147097 H2A histone family, member X Seq ID No: 3808, 381 103768 AF086009 Hs.296398 gb:Homo sapiens full length insert cDNA Seq ID No: 3828, 383 417512 X76534 Hs.82226 glycoprotein (transmembrane) nmb Seq ID No: 3848, 385 425266 J00077 Hs.155421 alpha-fetoprotein Seq ID No: 3868, 387 424503 NM.002205 Hs.149609 integrin, alpha 5 (fibronectin receptor, Seq ID No: 3888, 389 400289 X07820 Hs.2258 matrix metalloproteinase 10 (stromelysin Seq ID No: 390 & 391 418007 M13509 Hs.83169 matrix metalloproteinase 1 (interstitial Seq ID No: 3928, 393 418007 M13509 Hs.83169 matrix metalloproteinase 1 (interstitial Seq ID No: 3948.395 418738 AW388633 Hs.6682' solute carrier family 7, (cationic amino Seq ID No: 3968, 397 415138 C18356 Hs.295944 tissue factor pathway inhibitor 2 Seq ID No: 3988, 399 418506 AA084248 Hs.85339 G protein-coupled receptor 39 Seq ID No: 4008, 401 423961 D13666 Hs.136348 periostin (OSF-2os) Seq ID No: 4028, 403 414812 X72755 Hs.77367 monokine induced by gamma interferon Seq ID No: 4048, 405 417433 BE270266 Hs.82128 5T4 oncofetal trophoblast glycoprotein ^• Seq ID No: 4068, 407 417433 BE270266 Hs.82128 5T4 oncofetal trophoblast glycoprotein Seq ID No: 4088, 409 422867 L32137 Hs.1584 cartilage oligomerio matrix protein (pse Seq ID No: 4108, 411 428227 AA321649 Hs.2248 small inducible cytokine subfamily B (Cy Seq ID No: 4128, 413 444381 BE387335 Hs.283713 ESTs, Weakly similar to S64054 hypotheti Seq ID No: 4148, 415 400303 AA242758 Hs.79136 LIV-1 protein, estrogen regulated Seq ID No: 4168, 417 411789 AF245505 Hs.72157 Adlican Seq ID No: 4188, 419 428698 AA852773 Hs.334838 KIAA1866 protein Seq ID No: 4208, 421 450098 W27249 Hs.8109 hypothetical protein FLJ21080 Seq ID No: 4228, 423 421552 AF026692 Hs.105700 secreted frizzled-related protein 4 Seq ID No: 4248, 425 452747 BE153855 Hs.61460 Ig superfamily receptor LNIR Seq ID No: 4268, 427 450375 AA009647 a disintegrin and metalloproteinase doma Seq ID No: 4288, 429 426215 AW963419 Hs.155223 stanniocalcin 2 Seq ID No: 4308,431 425247 NMJ05940 Hs.155324 matrix metalloproteinase 11 (stromelysin Seq ID No: 4328, 433 432201 AI538613 Hs.298241 Transmembrane protease, serine 3 Seq ID No: 4348.435 427585 D31152 Hs.179729 collagen, type X, alpha 1 (Schmid metaph Seq ID No: 4368, 437 442117 AW664964 Hs.128899 ESTs; hypothetical protein for IMAGE:447 Seq ID No: 4388, 439 431211 M86849 Hs.323733 gap junction protein, beta 2, 26kD (conn Seq ID No: 4408, 441 447033 AI357412 Hs.157601 ESTs Seq ID No: 4428, 443 447033 AI357412 Hs.157601 ESTs Seq ID No: 4448, 445 447033 AI357412 Hs.157601 ESTs Seq ID No: 4468, 447 115522 BE614387 Hs.333893 c-Myc target JP01 Seq ID No: 4488, 449 410418 D31382 Hs.63325 transmembrane protease, serine 4 Seq ID No: 4508, 451 409041 AB033025 Hs.50081 Hypothetical protein, XP.051860 (KIAA119 Seq ID No: 4528, 453 409041 AB033025 Hs.50081 Hypothetical protein, XP.051860 (KIAA119 Seq ID No: 4548,455 452461 N78223 Hε.108106 transcription factor Seq ID No: 4568,457 412420 AL035668 Hs.73853 bone morphogenetic protein 2 Seq ID No: 4588, 459 416658 U03272 Hs.79432 fibrillin 2 (congenital contractural ara Seq ID No: 4608, 461 407811 AW190902 Hε.40098 cysteine knot superfamily 1, BMP antagon Seq ID No: : 4628, 463 437852 BE001836 Hs.256897 ESTs, Weakly similar to dJ365012.1 [H.εa Seq ID No: : 464 & 465 402075 ENSP00000251056*:Plaεma membrane calcium Seq ID No: : 466 & 467 421110 AJ250717 Hs.1355 cathepsiπ E Seq ID No: : 4688, 469 451668 Z43948 Hs.326444 cartilage acidic protein 1 Seq ID No: : 470 & 471 451668 Z43948 Hs.326444 cartilage acidic protein 1 Seq ID No: : 472 & 473 451668 Z43948 Hs.326444 cartilage acidic protein 1 Seq ID No: : 474 & 475 422282 AF019225 Hs.114309 apolipoprotein Seq ID No: : 476 & 477 425852 AK001504 Hs.159651 death receptor 6, TNF superfamily member Seq ID No: : 478 & 479 439738 BE246502 Hs.9598 sema domain, immunoglobulin domain (Ig), Seq ID No: -.4808.481 427747 AW411425 Hs.180655 serine/threonine kinase 12 Seq ID No: : 482 & 483 420281 AI623693 Hs.323494 Predicted cation efflux pump Seq ID No: : 484 & 485 405932 C15000305:gi|3806122|gb|AAC69198.1l (AF0 Seq ID No: : 486 & 487 405932 C15000305:gi|3806122|gb|AAC69198.11 (AF0 Seq ID No: : 488 & 489 444342 NM_014398 Hs.10887 similar to lysoεome-associated membrane SeqJD No: : 490 & 491 421379 Y15221 Hs.103982 small inducible cytokine subfamily B (Cy Seq ID No: : 492 & 493 417079 U65590 Hs.81134 interleukin 1 receptor antagonist Seq ID No: : 494 & 495 430890 X54232 Hs.2699 glypican 1 Seq ID No: : 496 & 497 419721 NM 001650 Hs.288650 aquaponn 4 Seq ID No: : 498 & 499 444471 AB020684 Hs.11217 KIAA0877 protein Seq ID No: : 500 & 501 413063 AL035737 Hs.75184 chitinase 3-like 1 (cartilage glycoprote Seq ID No: : 502 & 503 433800 AI034361 Hs.135150 lung type-l cell membrane-associated gly Seq ID No: : 5048, 505 452401 NM_007115 Hε.29352 tumor necrosis factor, alpha-induced pro Seq ID No: : 506 & 507 452401 NM 07115 Hs.29352 tumor necrosis factor, alpha-induced pro Seq ID No: : 508 & 509 450001 NM 001044 Hs.406 solute carrier family 6 (neurotransmitte Seq ID No: : 510 & 511 410407 X66839 Hs.63287 carbonic anhydraεe IX Seq ID No; : 512 & 513 309931 AW341683 gb:hd13d01.x1 Soares NFL_T_GBC_S1 Homo s Seq ID No: 5148.515 412719 AW016610 Hs.816 ESTs Seq ID No: : 5168, 517 417034 NM_006183 Hs.80962 neurotensin Seq ID No: : 5188, 519 430486 BE062109 Hs.241551 chloride channel, calcium activated, fam Seq ID No: 5208.521 413753 U17760 Hε.75517 laminin, beta 3 (nicein (125kD), kalinin Seq ID No: ; 522 & 523 425650 NM_001944 Hs.1925 desmoglein 3 (pemphigus vulgaris antigen Seq ID No: : 524 & 525 423673 BE003054 Hs.1695 matrix metalloproteinase 12 (macrophage Seq ID No: 5268.527 418663 AK001100 Hε.41690 desmocollln 3 Seq ID No: 5288.529 418663 AK001100 Hs.41690 desmocollin 3 Seq ID No: : 530 & 531 429610 AB024937 Hs.211092 LUNX protein; PLUNC (palate lung and nas Seq ID No: : 532 & 533 406690 M29540 Hs.220529 carcinoembryonic antigen-related cell ad Seq ID No: 534 & 535 431846 BE019924 Hs.271580 uroplakin 1B Seq ID No: 5368.537 422158 L10343 Hs.112341 protease inhibitor 3, skin-derived (SKAL Seq ID No: 5388.539 431958 X63629 Hs.2877 cadherin 3, type 1, P-cadherin (placenta Seq ID No: 5408.541 437044 AL035864 Hs.69517 differentially expressed in Fanconi's an Seq ID No: 542 & 543 428484 AF104032 Hs.184601 solute carrier family 7 (cationic amino Seq ID No: 5448.545 429211 AF052693 Hs.198249 gap junction protein, beta 5 (connexin 3 Seq ID No: 546 & 547 417389 BE260964 Hs.82045 midkine (neurite growth-promoting factor Seq ID No: 548 & 549 431009 BE149762 Hs.48956 gap junction protein, beta 6 (connexin 3 Seq ID No: 5508, 551 417542 J04129 Hs.82269 progestagen-asεociated endometrial prate Seq ID No: 5528, 553 449230 BE613348 Hs.211579 melanoma cell adhesion molecule Seq ID No: 5548, 555 410555 U92649 Hs.64311 a disintegrin and metalloproteinase doma Seq ID No: 556 & 557 410555 U92649 Hs.64311 a disintegrin and metalloproteinase doma Seq ID No: 558 & 559 424687 J05070 Hs.151738 matrix metalloproteinase 9 (gelatinase B Seq ID No: 5608, 561 418462 BE001596 Hε.85266 integrin, beta 4 Seq ID No: 5628, 563 410274 AA381807 Hs.61762 hypoxia-inducible protein 2 - Seq ID No: 5648, 565 439606 W79123 Hs.58561 G protein-coupled receptor 87 Seq ID No: 5668, 567 404877 NM_005365:Homo sapienε melanoma antigen, Seq ID No: 5688, 569 444781 NM.014400 Hs.11950 GPI-anchored metastasis-associated prote Seq ID No: 5708, 571 418543 NMJ05329 Hs.85962 hyaluronan synthase 3 Seq ID No: 572 & 573 415817 U88967 Hs.78667 protein tyrosine phosphatase, receptor-t Seq ID No: 5748, 575 415817 U88967 Hs.78867 protein tyrosine phosphatase, receptor-t Seq ID No: 5768, 577 415817 U88967 Hs.78867 protein tyrosine phosphatase, receptor-t Seq ID No: 5788, 579 415817 U88967 Hs.78867 protein tyrosine phosphataεe, receptor-t Seq ID No: 5808, 581 415817 U88967 Hs.78867 protein tyrosine phosphataεe, receptor-t Seq ID No: 5828, 583 415817 U88967 Hs.78867 protein tyrosine phosphatase, receptor-t Seq ID No: 5848, 585 421817 AF146074 Hs.108660 ATP-binding cassette, sub-family C (CFTR Seq ID No: 586 & 587 418678 NM.001327 Hs.167379 cancer/testis antigen (NY-ESO-1) Seq ID No: 5888, 589 418678 NMJ01327 Hs.167379 cancer/testiε antigen (NY-ESO-1) Seq ID No: 5908, 591 409420 Z15008 Hs.54451 laminin, gamma 2 (nicein (100kD), kalini Seq ID No: 5928, 593 332180 AF134160 Hε.7327 claudin 1 Seq ID No: 5948, 595 408790 AW580227 Hs.47860 neurotrophic tyrosine kinase, receptor, Seq ID No: 5968.597 408790 AW580227 Hs.47860 neurotrophic tyrosine kinase, receptor, Seq ID No: 5988, 599 439223 AW238299 Hs.250618 UL16 binding protein 2 Seq ID No: 600 Si 601 409757 NM_001898 Hs.123114 cystatin SN Seq ID No: 6028, 603 428969 AF120274 Hs.194689 artemin Seq ID No: 6048, 605 428969 AF120274 Hs.194689 artemin Seq ID No: 6068, 607 428969 AF120274 Hs.194689 artemin Seq ID No: 608 & 609 428969 AF120274 Hs.194689 artemin Seq ID No: 6108.611 450701 H39960 Hs.288467 hypothetical protein XP.098151 (leucine- Seq ID No: 6128.613 450701 H39960 Hs.288467 hypothetical protein XP_098151 (leucine- Seq ID No: 614 & 615 414774 X02419 Hs.77274 plasminogen activator, urokinase Seq ID No: 6168.617 407944 R34008 Hs.239727 desmocollin 2 Seq ID No: 6188.619 407944 R34008 Hε.239727 desmocollln 2 Seq ID No: 6208.621 457489 AI693815 Hs.127179 cryptic gene Seq ID No: 6228, 623 429547 AW009166 Hs.99376 ESTs Seq ID No: 6248.625 407242 M18728 gb:Human nonspecific crosεreacting antig Seq ID No: 626 & 627 407242 M18728 gb:Human nonspecific crosεreacting antig Seq ID No: 6288.629 407242 M18728 gb:Humaπ nonspecific crossreacting antig Seq ID No: 630 & 631 444006 BE395085 Hε.10086 type I transmembrane protein Fn14 Seq ID No: 632 & 633 429597 NM 003816 Hs.2442 a disintegrin and metalloproteinase doma

Seq ID No: 634 & 635 422109 S73265 Hs.1473 gastrin-releaεing peptide

Seq ID No: 636 & 637 419235 AW470411 Hs.288433 neurotrimin

Seq ID No: 638 & 639 449048 Z45051 Hs.22920 similar to S68401 (cattle) glucose indue

Seq ID No: 640 & 641 419216 AU076718 Hs.164021 small inducible cytokine subfamily B (Cy

Seq ID No: 6428.643 431462 AW583672 Hs.256311 granin-like neuraendocrine peptide precu

Seq ID No: 644 & 645 448243 AW369771 Hs.52620 Integrin, beta 8

Seq ID No: 646 & 647 426427 M86699 Hs.169840 TTK protein kinase

Seq ID No: 6488.649 445537 AJ245671 Hs.12844 EGF-like-domain, multiple 6

Seq ID No: 650 & 651 422278 AF072873 Hs.114218 frizzled (Drosophila) homolog 6

Seq ID No: 652 & 653 428450 NM 014791 Hs.184339 KIAA0175 gene product

Seq ID No: 654 & 655 446619 AU076643 Hs.313 secreted phosphoproteiπ 1 (osteopontin,

Seq ID No: 656 & 657 453392 U23752 Hs.32964 SRY (εex determining region Y)-box 11

Seq ID No: 658 & 659 426514 BE616633 Hs.170195 bone morphogenetio protein 7 (osteogenic

Seq ID No: 6608, 661 425776 U25128 Hs.159499 parathyroid hormone receptor 2

Seq ID No: 662 & 663 425776 U25128 Hs.159499 parathyroid hormone receptor 2

Seq ID No: 664 & 665 431515 NM 012152 Hs.258583 endothelial differentiation, lysophospha

Seq ID No: 6668, 667 419452 U33635 Hε.90572 PTK7 protein tyrosine kinase 7

Seq ID No: 668 & 669 432653 N62096 Hε.293185 ESTs, Weakly similar to JC7328 amino aci

Seq ID No: 670 & 671 432653 N62096 Hs.293185 ESTs, Weakly similar to JC7328 amino aci

Seq ID No: 672 & 673 432653 N62096 Hs.293185 ESTs, Weakly similar to JC7328 amino aci

Seq ID No: 674 & 675 432653 N62096 Hs.293185 ESTs, Weakly similar to JC7328 amino aci

Seq ID No: 6768.677 410001 AB041036 Hs.57771 kallikrei H

Seq ID No: 678 & 679 426501 AW043782 Hs.293616 ESTs

Seq ID No: 680 & 681 408369 R38438 Hs.182575 solute carrier family 15 (H??? transport

Seq ID No: 682 & 683 445413 AA151342 Hs.12677 CGI-147 protein

Seq ID No: 6848, 685 422424 AI186431 Hs.296638 prostate differentiation factor

Seq ID No: 686 & 687 428330 L22524 Hs.2256 matrix metalloproteinase 7 (matrilysin,

Seq ID No: 688 & 689 420610 AI683183 Hs.99348 distal-less homeo box 5

TABLE 15B

Pkey: Unique Eos probeset identifier number

CAT number: Gene cluster number Accession: Genbank accession numbers

Pkey CAT Number Accession

309931 AW341683

330493 33264 5 M27826 R78416 AA307645 AW957879 AW957800 AA633529 H03662

439285 47065 1 AL133916 N79113 AF086101 N76721 AW950828 AA364013 AW955684 AI346341 AI867454 N54784 AI655270 A1421279 AW014882

AA775552 N62351 N59253 AA626243 AI341407 BE175639 AA456968 AI358918 AA457077

450375 83327 1 AA009647 AA131254 AA374293 AW954405 H04410 AW606284 AA151166 BE157467 BE157601 H04384 W46291 AW663674 H04021 H01532

AA190993 H03231 H59605 H01642 AA852876 AA113758 AA626915 AA746952 AI161014 AA099554 R69067

451320 86576.1 AW118072 AI631982 T15734 AA224195 AI701458 W20198 F26326 AA890570 N90552 AW071907 AI671352 AI375892 T03517 R88265

AH 24088 AA224388 AI084316 AI354686 T33652 AI140719 AI720211 T03490 AI372637 T15415 AW205836 AA630384 T03515 T33230

AA017131 AA443303 T33623 AI222556 T33511 T33785 AI419606 D55612

TABLE 15C

Pkey: Unique number corresponding to an Eoε probeεet Ref: Sequence εource. The 7 digit numberε in thiε column are Genbank Identifier (GI) numbers. "Dunham I. et al." refers to the publication entitled "The DNA sequence of human chromosome 22." Dunham I. et al., Nature (1999) 402:489-495.

Strand: Indicates DNA strand from which exons were predicted. NLposition: Indicates nucleotide positions of predicted exons.

Pkey Ref Strand NLposition

402075 8117407 Plus 121907-122035,122804-122921,124019-124161,124455-124610,125672-126076

403329 8516120 Plus 96450-96598

403478 9958258 Plus 116458-116564

404440 7528051 Plus 80430-81581

404877 1519284 Plus 1095-2107

405770 2735037 Plus 61057-62075

405932 7767812 Minus 123525-123713

Table 16

Seq ID NO: 1 DNA sequence

Nucleic Acid Accession #: NM_001216

Coding sequence: 43..1422

11 21 31 41 51

GCCCGTACAC ACCGTGTGCT GGGACACCCC ACAGTCAGCC GCATGGCTCC CCTGTGCCCC 60 AGCCCCTGGC TCCCTCTGTT GATCCCGGCC CCTGCTCCAG GCCTCACTGT GCAACTGCTG 120 CTGTCACTGC TGCTTCTGAT GCCTGTCCAT CCCCAGAGGT TGCCCCGGAT GCAGGAGGAT 180 TCCCCCTTGG GAGGAGGCTC TTCTGGGGAA GATGACCCAC TGGGCGAGGA GGATCTGCCC 240 AGTGAAGAGG ATTCACCCAG AGAGGAGGAT CCACCCGGAG AGGAGGATCT ACCTGGAGAG 300 GAGGATCTAC CTGGAGAGGA GGATCTACCT GAAGTTAAGC CTAAATCAGA AGAAGAGGGC 360 TCCCTGAAGT TAGAGGATCT ACCTACTGTT GAGGCTCCTG GAGATCCTCA AGAACCCCAG 420 AATAATGCCC ACAGGGACAA AGAAGGGGAT GACCAGAGTC ATTGGCGCTA TGGAGGCGAC 480 CCGCCCTGGC CCCGGGTGTC CCCAGCCTGC GCGGGCCGCT TCCAGTCCCC GGTGGATATC 540 CGCCCCCAGC TCGCCGCCTT CTGCCCGGCC CTGCGCCCCC TGGAACTCCT GGGCTTCCAG S00 CTCCCGCCGC TCCCAGAACT GCGCCTGCGC AACAATGGCC ACAGTGTGCA ACTGACCCTG 660 CCTCCTGGGC TAGAGATGGC TCTGGGTCCC GGGCGGGAGT ACCGGGCTCT GCAGCTGCAT 720 CTGCACTGGG GGGCTGCAGG TCGTCCGGGC TCGGAGCACA CTGTGGAAGG CCACCGTTTC 780 CCTGCCGAGA TCCACGTGGT TCACCTCAGC ACCGCCTTTG CCAGAGTTGA CGAGGCCTTG 840 GGGCGCCCGG GAGGCCTGGC CGTGTTGGCC GCCTTTCTGG AGGAGGGCCC GGAAGAAAAC 900 AGTGCCTATG AGCAGTTGCT GTCTCGCTTG GAAGAAATCG CTGAGGAAGG CTCAGAGACT 960 CAGGTCCCAG GACTGGACAT ATCTGCACTC CTGCCCTCTG ACTTCAGCCG CTACTTCCAA 1020 TATGAGGGGT CTCTGACTAC ACCGCCCTGT GCCCAGGGTG TCATCTGGAC TGTGTTTAAC 1080 CAGACAGTGA TGCTGAGTGC TAAGCAGCTC CACACCCTCT CTGACACCCT GTGGGGACCT 1140 GGTGACTCTC GGCTACAGCT GAACTTCCGA GCGACGCAGC CTTTGAATGG GCGAGTGATT 1200 GAGGCCTCCT TCCCTGCTGG AGTGGACAGC AGTCCTCGGG CTGCTGAGCC AGTCCAGCTG 1260 AATTCCTGCC TGGCTGCTGG TGACATCCTA GCCCTGGTTT TTGGCCTCCT TTTTGCTGTC 1320 ACCAGCGTCG CGTTCCTTGT GCAGATGAGA AGGCAGCACA GAAGGGGAAC CAAAGGGGGT 1380 GTGAGCTACC GCCCAGCAGA GGTAGCCGAG ACTGGAGCCT AGAGGCTGGA TCTTGGAGAA 1440 TGTGAGAAGC CAGCCAGAGG CATCTGAGGG GGAGCCGGTA ACTGTCCTGT CCTGCTCATT 1500 ATGCCACTTC CTTTTAACTG CCAAGAAATT TTTTAAAATA AATATTTATA AT

Seq ID NO: 2 Protein sequence: Protein Accession #: NP 001207

11 21 31 41 51

1 I

MAP CPSPWLi P IPAPAPG LTVQ LSIi MPVHPQRL P 1RMQEDSP G GGSSGEDDP 60 GEEDLPSEED SPREEDPPGE EDLPGEEDLP GEEDLPEVKP KSEEEGS KL EDLPTVEAPG 120 DPQEPQNNAH RDKEGDDQSH WRYGGDPPWP RVSPACAGRF QSPVDIRPQ AAFCPA RPL 180 E LGFOLPPL PELRLRNNGH SVQIiT PPGIi EMALGPGREY RA Q HLHWG AAGRPGSEHT 240 VEGHRFPAEI HWH STAFA RVDEALGRPG GAVIAAF E EGPEENSAYE Q LSRLEEIA 300 EEGSETQVPG LDISA PSD FSRYFQYEGS LTTPPCAQGV IWTVFNQTVM SAKQLHTLS 360 DTLWGPGDSR LQLNFRATQP LNGRVIEASF PAGVDSSPRA AEPVQLNSC AAGDI ALVF 420 GL FAVTSVA FLVQMRRQHR RGTKGGVSYR PAEVAETGA

Seq ID NO: 3 DNA sequence

Nucleic Acid Accession #: BC013923

Coding sequence: 438-1391

11 21 31 41 51

I I

AGCGGGGTTG TCTATTAACT TGTTCAAAAA GTATCAGGAG TTGTCAAGGC AGAGAAGAGA 60 GTGTTTGCAA AAGGGGGAAA GTAGTTTGCT GCCTCTTTAA GACTAGGACT GAGAGAAAGA 120 AGAGGAGAGA GAAAGAAAGG GAGAGAAGTT TGAGCCCCAG GCTTAAGCCT TTCCAAAAAA 180 TAATAATAAC AATCATCGGC GGCGGCAGGA TCGGCCAGAG GAGGAGGGAA GCGCTTTTTT 240 TGATCCTGAT TCCAGTTTGC CTCTCTCTTT TTTTCCCCCA AATTATTCTT CGCCTGATTT 300 TCCTCGCGGA GCCCTGCGCT CCCGACACCC CCGCCCGCCT CCCCTCCTCC TCTCCCCCCG 360 CCCGCGGGCC CCCCAAAGTC CCGGCCGGGC CGAGGGTCGG CGGCCGCCGG CGGGCCGGGC 420 CCGCGCACAG CGCCCGCATG TACAACATGA TGGAGACGGA GCTGAAGCCG CCGGGCCCGC 480 AGCAAACTTC GGGGGGCGGC GGCGGCAACT CCACCGCGGC GGCGGCCGGC GGCAACCAGA 540 AAAACAGCCC GGACCGCGTC AAGCGGCCCA TGAATGCCTT CATGGTGTGG TCCCGCGGGC 600 AGCGGCGCAA GATGGCCCAG GAGAACCCCA AGATGCACAA CTCGGAGATC AGCAAGCGCC 660 TGGGCGCCGA GTGGAAACTT TTGTCGGAGA CGGAGAAGCG GCCGTTCATC GACGAGGCTA 720 AGCGGCTGCG AGCGCTGCAC ATGAAGGAGC ACCCGGATTA TAAATACCGG CCCCGGCGGA 780 AAACCAAGAC GCTCATGAAG AAGGATAAGT ACACGCTGCC CGGCGGGCTG CTGGCCCCCG 840 GCGGCAATAG CATGGCGAGC GGGGTCGGGG TGGGCGCCGG CCTGGGCGCG GGCGTGAACC 900 AGCGCATGGA CAGTTACGCG CACATGAACG GCTGGAGCAA CGGCAGCTAC AGCATGATGC 960 AGGACCAGCT GGGCTACCCG CAGCACCCGG GCCTCAATGC GCACGGCGCA GCGCAGATGC 1020 AGCCCATGCA CCGCTACGAC GTGAGCGCCC TGCAGTACAA CTCCATGACC AGCTCGCAGA 1080 CCTACATGAA CGGCTCGCCC ACCTACAGCA TGTCCTACTC GCAGCAGGGC ACCCCTGGCA 1140 TGGCTCTTGG CTCCATGGGT TCGGTGGTCA AGTCCGAGGC CAGCTCCAGC CCCCCTGTGG 1200 TTACCTCTTC CTCCCACTCC AGGGCGCCCT GCCAGGCCGG GGACCTCCGG GACATGATCA 1260 GCATGTATCT CCCCGGCGCC GAGGTGCCGG AACCCGCCGC GCCCAGCAGA CTTCACATGT 1320 CCCAGCACTA CCAGAGCGGC CCGGTGCCCG GCACGGCCAT TAACGGCACA CTGCCCCTCT 1380 CACACATGTG AGGGCCGGAC AGCGAACTGG AGGGGGGAGA AATTTTCAAA GAAAAACGAG 1440 GGAAATGGGA GGGGTGCAAA AGAGGAGAGT AAGAAACAGC ATGGAGAAAA CCCGGTACGC 1500 TCAAAAAAAA AAAAAAAAAA AAAATCCCAT CACCCACAGC AAATGACAGC TGCAAAAGAG 1560 AACACCAATC CCATCCACAC TCACGCAAAA ACCGCGATGC CGACAAGAAA ACTTTTATGA 1620 GAGAGATCCT GGACTTCTTT TKGGGGGACT ATTTTTGTAC AGAGAAAACC TGGGGAGGGT 1680 GGGGAGGGCG GGGGAATGGA CCTTGTATAG ATCTGGAGGA AAGAAAGCTA CGAAAAACTT 1740 TTTAAAAGTT CTAGTGGTAC GGTAGGAGCT TTGCAGGAAG TTTGCAAAAG TCTTTACCAA 1800 TAATATTTAG AGCTAGTCTC CAAGCGACGA AAAAAATGTT TTAATATTTG CAAGCAACTT 1860 TTGTACAGTA TTTATCGAGA TAAACATGGC AATCAAAATG TCCATTGTTT ATAAGCTGAG 1920 AATTTGCCAA TATTTTTCAA GGAGAGGCTT CTTGCTGAAT TTTGATTCTG CAGCTGAAAT 1980

TTAGGACAGT TGCAAACGTG AAAAGAAGAA AATTATTCAA ATTTGGACAT TTTAATTGTT 2040

TAAAAATTGT ACAAAAGGAA AAAATTAGAA TAAGTACTGG CGAACCATCT CTGTGGTCTT 2100

GTTTAAAAAG GGCAAAAGTT TTAGACTGTA CTAAATTTTA TAACTTACTG TTAAAAGCAA 2160

AAATGGCCAT GCAGGTTGAC ACCGTTGGTA ATTTATAATA GCTTTTGTTC GATCCCAACT 2220

TTCCATTTTG TTCAGATAAA AAAAACCATG AAATTACTGT GTTTGAAATA TTTTCTTATG 2280

GTTTGTAATA TTTCTGTAAA TTTATTGTGA TATTTTAAGG TTTTCCCCCC TTTATTTTCC 2340

GTAGTTGTAT TTTAAAAGAT TCGGCTCTGT ATTATTTGAA TCAGTCTGCC GAGAATCCAT 2400

GTATATATTT GAACTAATAT CATCCTTATA ACAGGTACAT TTTCAACTTA AGTTTTTACT 2460

CCATTATGCA CAGTTTGAGA TAAATAAATT TTTGAAATAT GGACACTGAA AAAAAAAAAA 2520

AAAAAAACAA AACAAAAAAA CAAAAAACAA AAACAGAAAA AACAAAAAAA AAAACAAAAC 2580

CACAACACAA AAACAAAAAA AAAAAAAAGA AACAAACACA CAACACAACA CAACACAAAA 2640 CCACAACACA AACAACAACA CACAGAGGG

Seq ID NO: 4 Protein sequence: Protein Accession #:CAA83435.1

11 21 31 41 51

I ! I I I

MYNMMETEIiK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA 60 QENPKMHNSE ISKR GAEHK LLSETEKRPF IDEAKR RAL HMKEHPDYKY RPRRKTKTLM 120 KKDKYT PGG IiLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY 180 PQHPG NAHG AAQMQPMHRY DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMA GSM 240 GSWKSEASS SPPWTSSSH SRAPCQAGDL RDMISMY PG AEVPEPAAPS RLHMSQHYQS 300 GPVPGTAING TLPLSHM

Seq ID NO : 5 DNA sequence Nucleic Acid Accession # : U91618 Coding sequence : 29-541

11 21 31 41 51

CGGACTTGGC TTGTTAGAAG GCTGAAAGAT GATGGCAGGA ATGAAAATCC AGCTTGTATG 60 CATGCTACTC CTGGCTTTCA GCTCCTGGAG TCTGTGCTCA GATTCAGAAG AGGAAATGAA 120 AGCATTAGAA GCAGATTTCT TGACCAATAT GCATACATCA AAGATTAGTA AAGCACATGT 180 TCCCTCTTGG AAGATGACTC TGCTAAATGT TTGCAGTCTT GTAAATAATT TGAACAGCCC 240 AGCTGAGGAA ACAGGAGAAG TTCATGAAGA GGAGCTTGTT GCAAGAAGGA AACTTCCTAC 300 TGCTTTAGAT GGCTTTAGCT TGGAAGCAAT GTTGACAATA TACCAGCTCC ACAAAATCTG 360 TCACAGCAGG GCTTTTCAAC ACTGGGAGTT AATCCAGGAA GATATTCTTG ATACTGGAAA 420 TGACAAAAAT GGAAAGGAAG AAGTCATAAA GAGAAAAATT CCTTATATTC TGAAACGGCA 480 GCTGTATGAG AATAAACCCA GAAGACCCTA CATACTCAAA AGAGATTCTT ACTATTACTG 540 AGAGAATAAA TCATTTATTT ACATGTGATT GTGATTCATC ATCCCTTAAT TAAATATCAA 600 ATTATATTTG TGTGAAAATG TGACAAACAC ACTTATCTGT CTCTTCTACA ATTGTGGTTT 660 ATTGAATGTG TTTTTCTGCA CTAATAGAAA TTAGACTAAG TGTTTTCAAA TAAATCTAAA 720 TCTTCAAAAA AAAAAAAAAA AAATGGGGCC GCAATT

Seq ID NO: 6 Protein sequence: Protein Accession #: AAB50564

1 11 21 31 41 51

1 I I I I I

MMAGMKIQ V CM LLAFSSW S CSDSEEEM KALEADFLTN MHTSKISKAH VPSwKMTL N 60 VCSLVNNLNS PAEETGEVHE EELVARRKLP TALDGFSLEA M TIYQ HKI CHSRAFQHWE 120 LIQEDI DTG NDKNGKEEVI KRKIPYI KR QLYENKPRRP YI KRDSYYY

Seq ID NO: 7 DNA sequence

Nucleic Acid Accession #: NM_006536.2 Coding sequence: 109-2940

11 21 31 41 51

ACCTAAAACC TTGCAAGTTC AGGAAGAAAC CATCTGCATC CATATTGAAA ACCTGACACA 60 ATGTATGCAG CAGGCTCAGT GTGAGTGAAC TGGAGGCTTC TCTACAACAT GACCCAAAGG 120 AGCATTGCAG GTCCTATTTG CAACCTGAAG TTTGTGACTC TCCTGGTTGC CTTAAGTTCA 180 GAACTCCCAT TCCTGGGAGC TGGAGTACAG CTTCAAGACA ATGGGTATAA TGGATTGCTC 240 ATTGCAATTA ATCCTCAGGT ACCTGAGAAT CAGAACCTCA TCTCAAACAT TAAGGAAATG 300 ATAACTGAAG CTTCATTTTA CCTATTTAAT GCTACCAAGA GAAGAGTATT TTTCAGAAAT 360 ATAAAGATTT TAATACCTGC CACATGGAAA GCTAATAATA ACAGCAAAAT AAAACAAGAA 420 TCATATGAAA AGGCAAATGT CATAGTGACT GACTGGTATG GGGCACATGG AGATGATCCA 480 TACACCCTAC AATACAGAGG GTGTGGAAAA GAGGGAAAAT ACATTCATTT CACACCTAAT 540 TTCCTACTGA ATGATAACTT AACAGCTGGC TACGGATCAC GAGGCCGAGT GTTTGTCCAT 600 GAATGGGCCC ACCTCCGTTG GGGTGTGTTC GATGAGTATA ACAATGACAA ACCTTTCTAC 660 ATAAATGGGC AAAATCAAAT TAAAGTGACA AGGTGTTCAT CTGACATCAC AGGCATTTTT 720 GTGTGTGAAA AAGGTCCTTG CCCCCAAGAA AACTGTATTA TTAGTAAGCT TTTTAAAGAA 780 GGATGCACCT TTATCTACAA TAGCACCCAA AATGCAACTG CATCAATAAT GTTCATGCAA 840 AGTTTATCTT CTGTGGTTGA ATTTTGTAAT GCAAGTACCC ACAACCAAGA AGCACCAAAC 900 CTACAGAACC AGATGTGCAG CCTCAGAAGT GCATGGGATG TAATCACAGA CTCTGCTGAC 960 TTTCACCACA GCTTTCCCAT GAATGGGACT GAGCTTCCAC CTCCTCCCAC ATTCTCGCTT 1020 GTACAGGCTG GTGACAAAGT GGTCTGTTTA GTGCTGGATG TGTCCAGCAA GATGGCAGAG 1080 GCTGACAGAC TCCTTCAACT ACAACAAGCC GCAGAATTTT ATTTGATGCA GATTGTTGAA 1140 ATTCATACCT TCGTGGGCAT TGCCAGTTTC GACAGCAAAG GAGAGATCAG AGCCCAGCTA 1200 CACCAAATTA ACAGCAATGA TGATCGAAAG TTGCTGGTTT CATATCTGCC CACCACTGTA 1260 TCAGCTAAAA CAGACATCAG CATTTGTTCA GGGCTTAAGA AAGGATTTGA GGTGGTTGAA 1320 AAACTGAATG GAAAAGCTTA TGGCTCTGTG ATGATATTAG TGACCAGCGG AGATGATAAG 1380 CTTCTTGGCA ATTGCTTACC CACTGTGCTC AGCAGTGGTT CAACAATTCA CTCCATTGCC 1440 CTGGGTTCAT CTGCAGCCCC AAATCTGGAG GAATTATCAC GTCTTACAGG AGGTTTAAAG 1500

TTCTTTGTTC CAGATATATC AAACTCCAAT AGCATGATTG ATGCTTTCAG TAGAATTTCC 1560

TCTGGAACTG GAGACATTTT CCAGCAACAT ATTCAGCTTG AAAGTACAGG TGAAAATGTC 1620

AAACCTCACC ATCAATTGAA AAACACAGTG ACTGTGGATA ATACTGTGGG CAACGACACT 1680

ATGTTTCTAG TTACGTGGCA GGCCAGTGGT CCTCCTGAGA TTATATTATT TGATCCTGAT 1740

GGACGAAAAT ACTACACAAA TAATTTTATC ACCAATCTAA CTTTTCGGAC AGCTAGTCTT 1800

TGGATTCCAG GAACAGCTAA GCCTGGGCAC TGGACTTACA CCCTGAACAA TACCCATCAT 1860

TCTCTGCAAG CCCTGAAAGT GACAGTGACC TCTCGCGCCT CCAACTCAGC TGTGCCCCCA 1920

GCCACTGTGG AAGCCTTTGT GGAAAGAGAC AGCCTCCATT TTCCTCATCC TGTGATGATT 1980

TATGCCAATG TGAAACAGGG ATTTTATCCC ATTCTTAATG CCACTGTCAC TGCCACAGTT 2040

GAGCCAGAGA CTGGAGATCC TGTTACGCTG AGACTCCTTG ATGATGGAGC AGGTGCTGAT 2100

GTTATAAAAA ATGATGGAAT TTACTCGAGG TATTTTTTCT CCTTTGCTGC AAATGGTAGA 2160

TATAGCTTGA AAGTGCATGT CAATCACTCT CCCAGCATAA GCACCCCAAC CCACTCTATT 2220

CCAGGGAGTC ATGCTATGTA TGTACCAGGT TACACAGCAA ACGGTAATAT TCAGATGAAT 2280

GCTCCAAGGA AATCAGTAGG CAGAAATGAG GAGGAGCGAA AGTGGGGCTT TAGCCGAGTC 2340

AGCTCAGGAG GCTCCTTTTC AGTGCTGGGA GTTCCAGCTG GCCCCCACCC TGATGTGTTT 2400

CCACCATGCA AAATTATTGA CCTGGAAGCT GTAAAAGTAG AAGAGGAATT GACCCTATCT 2460

TGGACAGCAC CTGGAGAAGA CTTTGATCAG GGCCAGGCTA CAAGCTATGA AATAAGAATG 2520

AGTAAAAGTC TACAGAATAT CCAAGATGAC TTTAACAATG CTATTTTAGT AAATACATCA 2580

AAGCGAAATC CTCAGCAAGC TGGCATCAGG GAGATATTTA CGTTCTCACC CCAGATTTCC 2640

ACGAATGGAC CTGAACATCA GCCAAATGGA GAAACACATG AAAGCCACAG AATTTATGTT 2700

GCAATACGAG CAATGGATAG GAACTCCTTA CAGTCTGCTG TATCTAACAT TGCCCAGGCG 2760

CCTCTGTTTA TTCCCCCCAA TTCTGATCCT GTACCTGCCA GAGATTATCT TATATTGAAA 2820

GOAGTTTTAA CAGCAATGGG TTTGATAGGA ATCATTTGCC TTATTATAGT TGTGACACAT 2880

CATACTTTAA GCAGGAAAAA GAGAGCAGAC AAGAAAGAGA ATGGAACAAA ATTATTATAA 2940

ATAAATATCC AAAGTGTCTT CCTTCTTAGA TATAAGACCC ATGGCCTTCG ACTACAAAAA 3000

CATACTAACA AAGTCAAATT AACATCAAAA CTGTATTAAA ATGCATTGAG TTTTTGTACA 3060

ATACAGATAA GATTTTTACA TGGTAGATCA ACAATTCTTT TTGGGGGTAG ATTAGAAAAC 3120

CCTTACACTT TGGCTATGAA CAAATAATAA AAATTATTCT TTAAAGTAAT GTCTTTAAAG 3180

GCAAAGGGAA GGGTAAAGTC GGACCAGTGT CAAGGAAAGT TTGTTTTATT GAGGTGGAAA 3240

AATAGCCCCA AGCAGAGAAA AGGAGGGTAG GTCTGCATTA TAACTGTCTG TGTGAAGCAA 3300

TCATTTAGTT ACTTTGATTA ATTTTTCTTT TCTCCTTATC TGTGCAGTAC AGGTTGCTTG 3360

TTTACATGAA GATCATGCTA TATTTTATAT ATGTAGCCCC TAATGCAAAG CTCTTTACCT 3420

CTTGCTATTT TGTTATATAT ATTTCAGATG ACATCTCCCT GCTAATGCTC AGAGATCTTT 3480

TTTCACTGTA AGAGGTAACC TTTAACAATA TGGGTATTAC CTTTGTCTCT TCATACCGGT 3540

TTTATGACAA AGGTCTATTG AATTTATTTG TNTGTAAGTT TCTACTCCCA TCAAAGCAGC 3600

TTTCTAAGTT TATTGCCTTG GGTTATTATG GAATGATAGT TATAGCCCCN TATAATGCCT 3660 TACCTAGGAA A Seq ID NO: 8 Protein sequence:

Protein Accession #: NP 006527.1

1 11 21 31 41 51

I I I I I I

MTQRSIAGPI CNLKFVT V ALSSELPF G AGVQLQDNGY NGLI.IAINPQ VPENQN ISN 60

IKEMITEASF YL.FNATKRRV FFRNIKILIP ATWKANNNSK IKQESYEKAN VIVTDWYGAH 120

GDDPYTLQYR GCGKEGKYIH FTPNFLLNDN TAGYGSRGR VFVHEWAHLR GVFDEYNND 180

KPFYINGQNQ IKVTRCSSDI TGIFVCEKGP CPQENCI ISK FKEGCTFIY NSTQNATASI 240

MFMQS SSW EFCNASTHNQ EAPN QNQMC SIiRSAWDVIT DSADFHHSFP MNGTE PPPP 300

TFS VQAGDK WCLVLDVSS KMAEADRL Q QQAAEFYLM QIVEIHTFVG IASFDSKGEI 360

RAQ HQINSN DDRK LiVSYL PTTVSAKTDI SICSG KKGF EWEKLNGKA YGSVMI VTS 420

GDDKLLGNCL PTV SSGSTI HSIALGSSAA PNIiEE SRLT GG KFFVPDI SNSNSMIDAF 480

SRISSGTGDI FQQHIQLEST GENVKPHHQL KNTVTVDNTV GNDTMFLVTW QASGPPEII 540

FDPDGRKYYT NNFITNLTFR TASLWIPGTA KPGHWTYTLN NTHHSLQALK VTVTSRASNS 600

AVPPATVEAF VERDSLHFPH PVMIYANVKQ GFYPI NATV TATVEPETGD PVT RL DDG 660

AGADVIKNDG IYSRYFFSFA ANGRYS KVH VNHSPSISTP AHSIPGSHAM YVPGYTANGN 720

IQ NAPRKSV GRNEEERKWG FSRVSSGGSF SVLGVPAGPH PDVFPPCKII DLEAVKVEEE 780 TLSWTAPGE DFDQGQATSY EIRMSKSLQN IQDDFNNAI VNTSKRNPQQ AGIREIFTFS 840

PQISTNGPEH QPNGETHESH RIYVAIRAMD RNS QSAVSN IAQAPLFIPP NSDPVPARDY 900 I KGV TAM G IGI ICLI I WTHHTLSRK KRADKKENGT KL

Seq ID NO : 9 DNA sequence

Nucleic Acid Accession # : Eos sequence

Coding sequence : 336 - 632

1 11 21 31 41 51

I I I I I I

CTCCCCTCAC CCCGGTCCAG GATGCCCAGT CCCCACGACA CCTCCCACTT CCCACTGTGβ 60

CCTGGGTGGG CTCAGGGGCT GCCCTTGACC TGGCCTAGAG CCCTCCCCCA GCTGGTGGTG 120

GAGCTGGCAC TCTCTGGGAG GGAGGGGGCT GGGAGGGAAT GAGTGGGAAT GGCAAGAGGC 180

CAGGGTTTGG TGGGATCAGG TTGAGGCAGG TTTGGTTTCC TTAAAATGCC AAGTTGGGGG 240

CCAGTGGGGC CCACATATAA ATCCTCACCC TGGGAGCCTG GCTGCCTTGC TCTCCTTCCT 300

GGGTCTGTCT CTGCCACCTG GTCTGCCACA GATCCATGAT GTGCAGTTCT CTGGAGCAGG 360

CGCTGGCTGT GCTGGTCACT ACCTTCCACA AGTACTCCTG CCAAGAGGGC GACAAGTTCA 420

AGCTGAGTAA GGGGGAAATG AAGGAACTTC TGCACAAGGA GCTGCCCAGC TTTGTGGGGG 480

AGAAAGTGGA TGAGGAGGGG CTGAAGAAGC TGATGGGCAG CCTGGATGAG AACAGTGACC 540

AGCAGGTGGA CTTCCAGGAG TATGCTGTTT TCCTGGCACT CATCACTGTC ATGTGCAATG 600

ACTTCTTCCA GGGCTGCCCA GACCGACCCT GAAGCAGAAC TCTTGACTTC CTGCCATGGA 660

TCTCTTGGGC CCAGGACTGT TGATGCCTTT GAGTTTTGTA TTCAATAAAC TTTTTTTGTC 720

TGTTGATAAT ATTTTAATTG CTCAGTGATG TTCCATAACC CGGCTGGCTC AGCTGGAGTG 780

CTGGGAGATG AGGGCCTCCT GGATCCTGCT CCCTTCTGGG CTCTGACTCT CCTGGAAATC 840

TCTCCAAGGC CAGAGCTATG CTTTAGGTCT CAATTTTGGA ATTTCAAACA CCAGCAAAAA 900

ATTGGAAATC GAGATAGGTT GCTGACTTTT ATTTTGTCAA ATAAAGATAT TAAAAAAGGC 960 AAATACCA

Seq ID NO : 10 Protein sequence : Protein Accession #: NP_005969.1

1 11 21 31 41 51

I I I I I I

MMCSSLEQAL AVLVTTFHKY SCQEGDKFK SKGEMKELLH KELPSFVGEK VDEEGLKKLM 60

GSLDENSDQQ VDFQEYAVF A ITVMCNDF FQGCPDRP

Seq ID NO : 11 DNA sequence

Nucleic Acid Accession # : Eos sequence

Coding sequence : 336-626

1 11 21 31 41 51

1 I I I I I

CTCCCCTCAC CCCGGTCCAG GATGCCCAGT CCCCACGACA CCTCCCACTT CCCACTGTGG 60

CCTGGGTGGG CTCAGGGGCT GCCCTTGACC TGGCCTAGAG CCCTCCCCCA GCTGGTGGTG 120

GAGCTGGCAC TCTCTGGGAG GGAGGGGGCT GGGAGGGAAT GAGTGGGAAT GGCAAGAGGC 180

CAGGGTTTGG TGGGATCAGG TTGAGGCAGG TTTGGTTTCC TTAAAATGCC AAGTTGGGGG 240

CCAGTGGGGC CCACATATAA ATCCTCACCC TGGGAGCCTG GCTGCCTTGC TCTCCTTCCT 300

GGGTCTGTCT CTGCCACCTG GTCTGCCACA GATCCATGAT GTGCAGTTCT CTGGAGCAGG 360

CGCTGGCTGT GCTGGTCACT ACCTTCCACA AGTACTCCTG CCAAGAGGGC GACAAGTTCA 420

AGCTGAGTAA GGGGGAAATG AAGGAACTTC TGCACAAGGA GCTGCCCAGC TTTGTGGGGC 480

ATTCCAGAGA ACCATGTGCT GTGAGGGCCT TCCGAGTCCA TCTGTTTAAT CCTGTCATTG 540

GAGACTTGAG AAACCAGAGC CCAGAAGGGA AAAGTGATTG TCCCAAGATC ACACAGCACT 600

GGAGAAAGTG GATGAGGAGG GGCTGAAGAA GCTGATGGGC AGCCTGGATG AGAACAGTGA 660

CCAGCAGGTG GACTTCCAGG AGTATGCTGT TTTCCTGGCA CTCATCACTG TCATGTGCAA 720

TGACTTCTTC CAGGGCTGCC CAGACCGACC CTGAAGCAGA ACTCTTGACT TCCTGCCATG 780

GATCTCTTGG GCCCAGGACT GTTGATGCCT TTGAGTTTTG TATTCAATAA ACTTTTTTTG 840

TCTGTTGATA ATATTTTAAT TGCTCAGTGA TGTTCCATAA CCCGGCTGGC TCAGCTGGAG 900

TGCTGGGAGA TGAGGGCCTC CTGGATCCTG CTCCCTTCTG GGCTCTGACT CTCCTGGAAA 960

TCTCTCCAAG GCCAGAGCTA TGCTTTAGGT CTCAATTTTG GAATTTCAAA CACCAGCAAA 1020

AAATTGGAAA TCGAGATAGG TTGCTGACTT TTATTTTGTC AAATAAAGAT ATTAAAAAAG 1080 GCAAATACCA

Seq ID NO: 12 Protein sequence: Protein Accession # : Eos sequence

1 11 21 31 41 51

I I I I I I

MMCSSLEQAL AVLVTTFHKY SCQEGDKFKL SKGEMKELLH KELPSFVGHS REPCAVRAFR 60 VHLFNPVIGD LRNQSPEGKS DCPKITQHWR KWMRRG Seq ID NO: 13 DNA sequence Nucleic Acid Accession #: Eos sequence Coding sequence: 58-354

1 11 21 31 41 51

G ITGAGCTCAC CIATGTGGGGG TIGAGGCTGAG AIGAAAACAAG TIACACAGCCA CIAGATCCATG 60

ATGTGCAGTT CTCTGGAGCA GGCGCTGGCT GTGCTGGTCA CTACCTTCCA CAAGTACTCC 120

TGCCAAGAGG GCGACAAGTT CAAGCTGAGT AAGGGGGAAA TGAAGGAACT TCTGCACAAG 180

GAGCTGCCCA GCTTTGTGGG GGAGAAAGTG GATGAGGAGG GGCTGAAGAA GCTGATGGGC 240

AGCCTGGATG AGAACAGTGA CCAGCAGGTG GACTTCCAGG AGTATGCTGT TTTCCTGGCA 300

CTCATCACTG TCATGTGCAA TGACTTCTTC CAGGGCTGCC CAGACCGACC CTGAAGCAGA 360

ACTCTTGACT TCCTGCCATG GATCTCTTGG GCCCAGGACT GTTGATGCCT TTGAGTTTTG 420

TATTCAATAA ACTTTTTTTG TCTGTTGATA ATATTTTAAT TGCTCAGTGA TGTTCCATAA 480

CCCGGCTGGC TCAGCTGGAG TGCTGGGAGA TGAGGGCCTC CTGGATCCTG CTCCCTTCTG 540

GGCTCTGACT CTCCTGGAAA TCTCTCCAAG GCCAGAGCTA TGCTTTAGGT CTCAATTTTG 600

GAATTTCAAA CACCAGCAAA AAATTGGAAA TCGAGATAGG TTGCTGACTT TTATTTTGTC 660 AAATAAAGAT ATTAAAAAAG GCAAATACCA

Seq ID NO: 14 Protein sequence:

Protein Accession #: NP_005969.1

1 11 21 31 41 51

I I I I 1 I

MMCSSLEQAL AVLVTTFHKY SCQEGDKFKL SKGEMKELLH KELPSFVGEK VDEEGLKKLM 60 GSLDENSDQQ VDFQEYAVFL ALITVMCNDF FQGCPDRP

Seq ID NO: 15 DNA sequence

Nucleic Acid Accession #: Eos sequence

Coding sequence: 62-358

1 11 21 31 41 51

I I I I I I

GGAGGGTGTG CCGCTGAGTC ACTGCCTGGG CATCTGGGCC TGGAACCTCG GCCACAGATC 60

CATGATGTGC AGTTCTCTGG AGCAGGCGCT GGCTGTGCTG GTCACTACCT TCCACAAGTA 120

CTCCTGCCAA GAGGGCGACA AGTTCAAGCT GAGTAAGGGG GAAATGAAGG AACTTCTGCA 180

CAAGGAGCTG CCCAGCTTTG TGGGGGAGAA AGTGGATGAG GAGGGGCTGA AGAAGCTGAT 240

GGGCAGCCTG GATGAGAACA GTGACCAGCA GGTGGACTTC CAGGAGTATG CTGTTTTCCT 300

GGCACTCATC ACTGTCATGT GCAATGACTT CTTCCAGGGC TGCCCAGACC GACCCTGAAG 360

CAGAACTCTT GACTTCCTGC CATGGATCTC TTGGGCCCAG GACTGTTGAT GCCTTTGAGT 420

TTTGTATTCA ATAAACTTTT TTTGTCTGTT GATAATATTT TAATTGCTCA GTGATGTTCC 480

ATAACCCGGC TGGCTCAGCT GGAGTGCTGG GAGATGAGGG CCTCCTGGAT CCTGCTCCCT 540

TCTGGGCTCT GACTCTCCTG GAAATCTCTC CAAGGCCAGA GCTATGCTTT AGGTCTCAAT 600

TTTGGAATTT CAAACACCAG CAAAAAATTG GAAATCGAGA TAGGTTGCTG ACTTTTATTT 660 TGTCAAATAA AGATATTAAA AAAGGCAAAT ACCA

Seq ID NO: 16 Protein sequence: Protein Accession #: NP 005969.1

11 41 51

MMCSSLEQAL AVLVTTFHKY SCQEGDKFKL SKGEMKELLH KIELPSFVGEK VDEEGLKKLM 60 GSLDENSDQQ VDFQEYAVFL ALITVMCNDF FQGCPDRP

Seq ID NO: 17 DNA sequence

Nucleic Acid Accession #: Eos sequence

Coding sequence: 939-2372

11 21 31 41 51

AAGACGGATT CTCAGACAAG GCTTGCAAAT GCCCCGCAGC CATCATTTAA CTGCACCCGC 60 AGAATAGTTA CGGTTTGTCA CCCGACCCTC CCGGATCGCC TAATTTGTCC CTAGTGAGAC 120 CCCGAGGCTC TGCCCGCGCC TGGCTTCTTC GTAGCTGGAT GCATATCGTG CTCCGGGCAβ 180 CGCGGGCGCA GGGCACGCGT TCGCGCACAC CCTAGCACAC ATGAACACGC GCAAGAGCTβ 240 AACCAAGCAC GGTTTCCATT TCAAAAAGGG AGACAGCCTC TACCGCGATT GTAGAAGAGA 300 CTGTGGTGTG AATTAGGGAC CGGGAGGCGT CGAACGGAGG AACGGTTCAT CTTAGAGACT 360 AATTTTCTGG AGTTTCTGCC CCTGCTCTGC GTCAGCCCTC ACGTCACTTC GCCAGCAGTA 420 GCAGAGGCGG CGGCGGCGGC TCCCGGAATT GGGTTGGAGC AGGAGCCTCG CTGGCTGCTT 480 CGCTCGCGCT CTACGCGCTC AGTCCCCGGC GGTAGCAGGA GCCTGGACCC AGGCGCCGCC 540 GGCGGGCGTG AGGCGCCGGA GCCCGGCCTC GAGGTGCATA CCGGACCCCC ATTCGCATCT 600 AACAAGGAAT CTGCGCCCCA GAGAGTCCCG GGAGCGCCGC CGGTCGGTGC CCGGCGCGCC 660 GGGCCATGCA GCGACGGCCG CCGCGGAGCT CCGAGCAGCG GTAGCGCCCC CCTGTAAAGC 720 GGTTCGCTAT GCCGGGGCCA CTGTGAACCC TGCCGCCTGC CGGAACACTC TTCGCTCCGG 780 ACCAGCTCAG CCTCTGATAA GCTGGACTCG GCACGCCCGC AACAAGCACC GAGGAGTTAA 840 GAGAGCCGCA AGCGCAGGGA AGGCCTCCCC GCACGGGTGG GGGAAAGCGG CCGGTGCAGC 900 GCGGGGACAG GCACTCGGGC TGGCACTGGC TGCTAGGGAT GTCGTCCTGG ATAAGGTGGC 960 ATGGACCCGC CATGGCGCGG CTCTGGGGCT TCTGCTGGCT GGTTGTGGGC TTCTGGAGGG 1020 CCGCTTTCGC CTGTCCCACG TCCTGCAAAT GCAGTGCCTC TCGGATCTGG TGCAGCGACC 1080 CTTCTCCTGG CATCGTGGCA TTTCCGAGAT TGGAGCCTAA CAGTGTAGAT CCTGAGAACA 1140 TCACCGAAAT TTTCATCGCA AACCAGAAAA GGTTAGAAAT CATCAACGAA GATGATGTTG 1200 AAGCTTATGT GGGACTGAGA AATCTGACAA TTGTGGATTC TGGATTAAAA TTTGTGGCTC 1260 ATAAAGCATT TCTGAAAAAC AGCAACCTGC AGCACATCAA TTTTACCCGA AACAAACTGA 1320 CGAGTTTGTC TAGGAAACAT TTCCGTCACC TTGACTTGTC TGAACTGATC CTGGTGGGCA 1380 ATCCATTTAC ATGCTCCTGT GACATTATGT GGATCAAGAC TCTCCAAGAG GCTAAATCCA 1440 GTCCAGACAC TCAGGATTTG TACTGCCTGA ATGAAAGCAG CAAGAATATT CCCCTGGCAA 1500 ACCTGCAGAT ACCCAATTGT GGTTTGCCAT CTGCAAATCT GGCCGCACCT AACCTCACTβ 1560 TGGAGGAAGG AAAGTCTATC ACATTATCCT GTAGTGTGGC AGGTGATCCG GTTCCTAATA 1620 TGTATTGGGA TGTTGGTAAC CTGGTTTCCA AACATATGAA TGAAACAAGC CACACACAGG 1680 GCTCCTTAAG GATAACTAAC ATTTCATCCG ATGACAGTGG GAAGCAGATC TCTTGTGTGG 1740 CGGAAAATCT TGTAGGAGAA GATCAAGATT CTGTCAACCT CACTGTGCAT TTTGCACCAA 1800 CTATCACATT TCTCGAATCT CCAACCTCAG ACCACCACTG GTGCATTCCA TTCACTGTGA 1860 AAGGCAACCC CAAACCAGCG CTTCAGTGGT TCTATAACGG GGCAATATTG AATGAGTCCA 1920 AATACATCTG TACTAAAATA CATGTTACCA ATCACACGGA GTACCACGGC TGCCTCCAGC 1980 TGGATAATCC CACTCACATG AACAATGGGG ACTACACTCT AATAGCCAAG AATGAGTATG 2040 GGAAGGATGA GAAACAGATT TCTGCTCACT TCATGGGCTG GCCTGGAATT GACGATGGTG 2100 CAAACCCAAA TTATCCTGAT GTAATTTATG AAGATTATGG AACTGCAGCG AATGACATCG 2160 GGGACACCAC GAACAGAAGT AATGAAATCC CTTCCACAGA CGTCACTGAT AAAACCGGTC 2220 GGGAACATCT CTCGGTCTAT GCTGTGGTGG TGATTGCGTC TGTGGTGGGA TTTTGCCTTT 2280 TGGTAATGCT GTTTCTGCTT AAGTTGGCAA GACACTCCAA GTTTGGCATG AAAGGTTTTG 2340 TTTTGTTTCA TAAGATCCCA CTGGATGGGT AGCTGAAATA AAGGAAAAGA CAGAGAAAGG 2400 GGCTGTGGTG CTTGTTGGTT GATGCTGCCA TGTAAGCTGG ACTCCTGGGA CTGCTGTTGG 2460 CTTATCCCGG GAAGTGCTGC TTATCTGGGG TTTTCTGGTA GATGTGGGCG GTGTTTGGAβ 2520 GCTGTACTAT ATGAAGCCTG CATATACTGT GAGCTGTGAT TGGGGAACAC CAATGCAGAG 2580 GTAACTCTCA GGCAGCTAAG CAGCACCTCA AGAAAACATG TTAAATTAAT GCTTCTCTTC 2640 TTACAGTAGT TCAAATACAA AACTGAAATG AAATCCCATT GGATTGTACT TCTCTTCTGA 2700 AAAGTGTGCT TTTTGACCCT ACTGGACATT TATTGACTTA ATTGCTTCTG TTTATTAAAA 2760 TTGACCTGCA AAGTTAAAAA AAAATTAAAG TTGAGAACAG GTATAAGTGC ACACTGAATA 2820 GTCTAATCTA CATGTAACAC ATATTTTAGT GTGATTTTCT ATACTCTAAT CAGCACTGAA 2880 TTCAGAGGGT TTGACTTTTT CATCTATAAC ACAGTGACTA AAAGAGTTAA GGGTATATAT 2940 ACCATCACTT TGGGACTTGG TAGTATTATT AAAAGGTTAT TTCCTTCACT GTCAATAAAA 3000 GTCCAAATGT TTAGCTTAGG TCTGAGAGTC AAACAATGTT AAGGATTGTC TTAAAGTTCC 3060 TTAGCCAGCA AAACAAAACA AAACAAAACA AACAAATGAA AAACGTTTAA AAAGAAGAAG 3120 AAGAAAAAAA ACAAGAACAA GCAGCAACAG CTGTTTTGTT GGGGCTATAG ATTTAAGTTA 3180 GGCATAGTCA ATTTCAGAAT AACTAAGAGT GGAATATATG CATATGGTGA AATTATAACC 3240 TTGCCCTTTT TTATTTGCCC TCTGCGATCC ACCTGCTTTT TAGAAGTCTG CCGAGTGAGA 3300 AGGCCACAGT ATCTCATGCT GTTTGCATTA CAGAACTGCA GCTTTTCTAC TCTGAAAAGG 3360 CCTGGGAGCA GAATGGCTGG CCTGCTGTGA GCAGGAGAGG AGATTCTAAG AAGGATAGTC 3420 CCCCCTACAA CATACTGTCA TACTGCTGGG TTTTCATGGG TAGGAAAGCT TGTCCTGACC 3480 CCAGCAGCAA AGAGGTGGCA GGTCGC AAT GAATATATGC TTTATAATGT CCTTCTTCAT 3540 TGCTGAGAGG GCAGCCTTAG AGCTGTGGAT TTCTGCATCC CCCCTGAGTC TGACCCATGG 3600 ACACCTGTTT CATTCACTTT AGCATCACAG TGACCTTTGT ATGCTCTGTT CAGTCTGTGT 3660 CAGGCAGTAT GCTTGTCCTG AAGAGAGGTT TGGCTATCCC CACCCCACCC CACCCCACCC 3720 TGTTCCTTTT TTATCAGGAG GACTTCAGAG CCAGGCCTGC AGCATTTTGT TTGAAAACAC 3780 AATCAGCTCT GACAGTTAGA CATGCACACA GACGCCATAG CTGGATTGGA AACATTGATG 3840 TTTTAAAAAT TTATTTTTTT TGGAAATAGT TGCACAAATG CTGCAATTTA GCTTTAAGGT 3900 TCTATAGATT TTTAACTAGT CCAACACAGT CAGAAACATT GTTTTGAATC CTCTGTAAAC 3960 CAAGGCATTA ATCTTAATAA ACCAGGATCC ATTTAGGTAC CACTTGATAT AAAAAGGATA 4020 TCCATAATGA ATATTTTATA CTGCATCCTT TACATTAGCC ACTAAATACG TTATTGCTTG 4080 ATGAAGACCT TTCACAGAAT CCTATGGATT GCAGCATTTC ACTTGGCTAC TTCATACCCA 4140 TGCCTTAAAG AGGGGCAGTT TCTCAAAAGC AGAAACATGC CGCCAGTTCT CAAGTTTTCC 4200

TCCTAACTCC ATTTGAATGT AAGGGCAGCT GGCCCCCAAT GTGGGGAGGT CCGAACATTT 4260

TCTGAATTCC CATTTTCTTG TTCGCGGCTA AATGACAGTT TCTGTCATTA CTTAGATTCC 4320

GATCTTTCCC AAAGGTGTTG ATTTACAAAG AGGCCAGCTA ATAGCAGAAA TCATGACCCT 4380

GAAAGAGAGA TGAAATTCAA GCTGTGAGCC AGGCAGGAGC TCAGTATGGC AAAGGTTCTT 4440

GAGAATCAGC CATTTGGTAC AAAAAAGATT TTTAAAGCTT TTATGTTATA CCATGGAGCC 4500

ATAGAAAGGC TATGGATTGT TTAAGAACTA TTTTAAAGTG TTCCAGACCC AAAAAGGAAA 4560

AATAAAAAAA AAGGAATATT TGTACCCAAC AGCTAGAAGG ATTGCAAGGT AGATTTTTGT 4620

TTTAAAATGG AGAGAAGTGG ACAGATAAGG CCATTTAATA TATCAAAGAT CAGTTGACAT 4680 CTCCTAGGGA ATGATGAAAA CAGCAGGCTA T

Seq ID NO: 18 Protein sequence: Protein Accession #: CAA53571

11 21 31 41 51

I I I

MSSWIRWHGP AMARL GFCW LWGFWRAAF ACPTSCKCSA SRIWCSDPSP GIVAFPRLEP 60 NSVDPENITE IFIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAHKA FLKNSNLQHI 120 NFTRNKLTSL SRKHFRHLDL SELILVGNPF TCSCDIMWIK TLQEAKSSPD TQDLYCLNES 180 SKNIPLANLQ IPNCGLPSAN LAAPNLTVEE GKSITLSCSV AGDPVPNMYW DVGNLVSKHM 240 NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 300 WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT 360 LIAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNRSNEIPST 420 DVTDKTGREH LSVYAVWIA SWGFCLLVM LFLLKLARHS KFGMKGFVLF HKIPLDG

Seq ID NO: 19 DNA sequence

Nucleic Acid Accession #: NM_000228

Coding sequence: 82-3600

1 11 21 31 G 1CTTTCAGGC G1ATCTGGAGA A1AGAACGGCA G1AACACACAG CAAGGAAAGG TCCTTTCTGG 60 GGATCACCCC ATTGGCTGAA GATGAGACCA TTCTTCCTCT TGTGTTTTGC CCTGCCTGGC 120 CTCCTGCATG CCCAACAAGC CTGCTCCCGT GGGGCCTGCT ATCCACCTGT TGGGGACCTG 180 CTTGTTGGGA GGACCCGGTT TCTCCGAGCT TCATCTACCT GTGGACTGAC CAAGCCTGAG 240 ACCTACTGCA CCCAGTATGG CGAGTGGCAG ATGAAATGCT GCAAGTGTGA CTCCAGGCAG 300 CCTCACAACT ACTACAGTCA CCGAGTAGAG AATGTGGCTT CATCCTCCGG CCCCATGCGC 360 TGGTGGCAGT CCCAGAATGA TGTGAACCCT GTCTCTCTGC AGCTGGACCT GGACAGGAGA 420 TTCCAGCTTC AAGAAGTCAT GATGGAGTTC CAGGGGCCCA TGCCCGCCGG CATGCTGATT 480 GAGCGCTCCT CAGACTTCGG TAAGACCTGG CGAGTGTACC AGTACCTGGC TGCCGACTGC 540 ACCTCCACCT TCCCTCGGGT CCGCCAGGGT CGGCCTCAGA GCTGGCAGGA TGTTCGGTGC 600 CAGTCCCTGC CTCAGAGGCC TAATGCACGC CTAAATGGGG GGAAGGTCCA ACTTAACCTT 660 ATGGATTTAG TGTCTGGGAT TCCAGCAACT CAAAGTCAAA AAATTCAAGA GGTGGGGGAG 720 ATCACAAACT TGAGAGTCAA TTTCACCAGG CTGGCCCCTG TGCCCCAAAG GGGCTACCAC 780 CCTCCCAGCG CCTACTATGC TGTGTCCCAG CTCCGTCTGC AGGGGAGCTG CTTCTGTCAC 840 GGCCATGCTG ATCGCTGCGC ACCCAAGCCT GGGGCCTCTG CAGGCCCCTC CACCGCTGTG 900 CAGGTCCACG ATGTCTGTGT CTGCCAGCAC AACACTGCCG GCCCAAATTG TGAGCGCTGT 960 GCACCCTTCT ACAACAACCG GCCCTGGAGA CCGGCGGAGG GCCAGGACGC CCATGAATGC 1020 CAAAGGTGCG ACTGCAATGG GCACTCAGAG ACATGTCACT TTGACCCCGC TGTGTTTGCC 1080 GCCAGCCAGG GGGCATATGG AGGTGTGTGT GACAATTGCC GGGACCACAC CGAAGGCAAG 1140 AACTGTGAGC GGTGTCAGCT GCACTATTTC CGGAACCGGC GCCCGGGAGC TTCCATTCAG 1200 GAGACCTGCA TCTCCTGCGA GTGTGATCCG GATGGGGCAG TGCCAGGGGC TCCCTGTGAC 1260 CCAGTGACCG GGCAGTGTGT GTGCAAGGAG CATGTGCAGG GAGAGCGCTG TGACCTATGC 1320 AAGCCGGGCT TCACTGGACT CACCTACGCC AACCCGCAGG GCTGCCACCG CTGTGACTGC 1380 AACATCCTGG GGTCCCGGAG GGACATGCCG TGTGACGAGG AGAGTGGGCG CTGCCTTTGT 1440 CTGCCCAACG TGGTGGGTCC CAAATGTGAC CAGTGTGCTC CCTACCACTG GAAGCTGGCC 1500 AGTGGCCAGG GCTGTGAACC GTGTGCCTGC GACCCGCACA ACTCCCCTCA GCCCACAGTG 1560 CAACCAGTTC ACAGGGCAGT GCCCTGTCGG GAAGGCTTTG GTGGCCTGAT GTGCAGCGCT 1620 GCAGCCATCC GCCAGTGTCC AGACCGGACC TATGGAGACG TGGCCACAGG ATGCCGAGCC 1680 TGTGACTGTG ATTTCCGGGG AACAGAGGGC CCGGGCTGCG ACAAGGCATC AGGCCGCTGC 1740 CTCTGCCGCC CTGGCTTGAC CGGGCCCCGC TGTGACCAGT GCCAGCGAGG CTACTGCAAT 1800 CGCTACCCGG TGTGCGTGGC CTGCCACCCT TGCTTCCAGA CCTATGATGC GGACCTCCGG 1860 GAGCAGGCCC TGCGCTTTGG TAGACTCCGC AATGCCACCG CCAGCCTGTG GTCAGGGCCT 1920 GGGCTGGAGG ACCGTGGCCT GGCCTCCCGG ATCCTAGATG CAAAGAGTAA GATTGAGCAG 1980 ATCCGAGCAG TTCTCAGCAG CCCCGCAGTC ACAGAGCAGG AGGTGGCTCA GGTGGCCAGT 2040 GCCATCCTCT CCCTCAGGCG AACTCTCCAG GGCCTGCAGC TGGATCTGCC CCTGGAGGAG 2100 GAGACGTTGT CCCTTCCGAG AGACCTGGAG AGTCTTGACA GAAGCTTCAA TGGTCTCCTT 2160 ACTATGTATC AGAGGAAGAG GGAGCAGTTT GAAAAAATAA GCAGTGCTGA TCCTTCAGGA 2220 GCCTTCCGGA TGCTGAGCAC AGCCTACGAG CAGTCAGCCC AGGCTGCTCA GCAGGTCTCC 2280 GACAGCTCGC GCCTTTTGGA CCAGCTCAGG GACAGCCGGA GAGAGGCAGA GAGGCTGGTG 2340 CGGCAGGCGG GAGGAGGAGG AGGCACCGGC AGCCCCAAGC TTGTGGCCCT GAGGCTGGAG 2400 ATGTCTTCGT TGCCTGACCT GACACCCACC TTCAACAAGC TCTGTGGCAA CTCCAGGCAG 2460 ATGGCTTGCA CCCCAATATC ATGCCCTGGT GAGCTATGTC CCCAAGACAA TGGCACAGCC 2520 TGTGGCTCCC GCTGCAGGGG TGTCCTTCCC AGGGCCGGTG GGGCCTTCTT GATGGCGGGG 2580 CAGGTGGCTG AGCAGCTGCG GGGCTTCAAT GCCCAGCTCC AGCGGACCAG GCAGATGATT 2640 AGGGCAGCCG AGGAATCTGC CTCACAGATT CAATCCAGTG CCCAGCGCTT GGAGACCCAG 2700 GTGAGCGCCA GCCGCTCCCA GATGGAGGAA GATGTCAGAC GCACACGGCT CCTAATCCAG 2760 CAGGTCCGGG ACTTCCTAAC AGACCCCGAC ACTGATGCAG CCACTATCCA GGAGGTCAGC 2820 GAGGCCGTGC TGGCCCTGTG GCTGCCCACA GACTCAGCTA CTGTTCTGCA GAAGATGAAT 2880 GAGATCCAGG CCATTGCAGC CAGGCTCCCC AACGTGGACT TGGTGCTGTC CCAGACCAAG 2940 CAGGACATTG CGCGTGCCCG CCGGTTGCAG GCTGAGGCTG AGGAAGCCAG GAGCCGAGCC 3000 CATGCAGTGG AGGGCCAGGT GGAAGATGTG GTTGGGAACC TGCGGCAGGG GACAGTGGCA 3060 CTGCAGGAAG CTCAGGACAC CATGCAAGGC ACCAGCCGCT CCCTTCGGCT TATCCAGGAC 3120 AGGGTTGCTG AGGTTCAGCA GGTACTGCGG CCAGCAGAAA AGCTGGTGAC AAGCATGACC 3180 AAGCAGCTGG GTGACTTCTG GACACGGATG GAGGAGCTCC GCCACCAAGC CCGGCAGCAG 3240 GGGGCAGAGG CAGTCCAGGC CCAGCAGCTT GCGGAAGGTG CCAGCGAGCA GGCATTGAGT 3300 GCCCAAGAGG GATTTGAGAG AATAAAACAA AAGTATGCTG AGTTGAAGGA CCGGTTGGGT 3360 CAGAGTTCCA TGCTGGGTGA GCAGGGTGCC CGGATCCAGA GTGTGAAGAC AGAGGCAGAG 3420

GAGCTGTTTG GGGAGACCAT GGAGATGATG GACAGGATGA AAGACATGGA GTTGGAGCTG 3480

CTGCGGGGCA GCCAGGCCAT CATGCTGCGC TCGGCGGACC TGACAGGACT GGAGAAGCGT 3540

GTGGAGCAGA TCCGTGACCA CATCAATGGG CGCGTGCTCT ACTATGCCAC CTGCAAGTGA 3600

TGCTACAGCT TCCAGCCCGT TGCCCCACTC ATCTGCCGCC TTTGCTTTTG GTTGGGGGCA 3660

GATTGGGTTG GAATGCTTTC CATCTCCAGG AGACTTTCAT GCAGCCTAAA GTACAGCCTG 3720

GACCACCCCT GGTGTGTAGC TAGTAAGATT ACCCTGAGCT GCAGCTGAGC CTGAGCCAAT 3780

GGGACAGTTA CACTTGACAG ACAAAGATGG TGGAGATTGG CATGCCATTG AAACTAAGAG 3840

CTCTCAAGTC AAGGAAGCTG GGCTGGGCAG TATCCCCCGC CTTTAGTTCT CCACTGGGGA 3900

GGAATCCTGG ACCAAGCACA AAAACTTAAC AAAAGTGATG TAAAAATGAA AAGCCAAATA 3960 AAAATCTTTG G

Seq ID NO: 20 Protein sequence: Protein Accession #: NP_000219

1 11 21 31 41 51

MRPFFLLCFA LPGLLHAQQA CSRGACYPPV GDLLVGRTRF LRASSTCGLT KPETYCTQYG 60

EWQMKCCKCD SRQPHNYYSH RVENVASSSG PMRW QSQND VNPVSLQLDL DRRFQLQEVM 120 MEFQGPMPAG MLIERSSDFG KTWRVYQYLA ADCTSTFPRV RQGRPQSWQD VRCQSLPQRP 180

NARLNGGKVQ LNLMDLVSGI PATQSQKIQE VGEITNLRVN FTRLAPVPQR GYHPPSAYYA 240

VSQLRLQGSC FCHGHADRCA PKPGASAGPS TAVQVHDVCV CQHNTAGPNC ERCAPFYNNR 300

PWRPAEGQDA HECQRCDCNG HSETCHFDPA VFAASQGAYG GVCDNCRDHT EGKNCERCQL 360

HYFRNRRPGA SIQETCISCE CDPDGAVPGA PCDPVTGQCV CKEHVQGERC DLCKPGFTGL 420 TYANPQGCHR CDCNILGSRR DMPCDEESGR CLCLPNWGP KCDQCAPYHW KLASGQGCEP 480

CACDPHNSPQ PTVQPVHRAV PCREGFGGLM CSAAAIRQCP DRTYGDVATG CRACDCDFRG 540

TEGPGCDKAS GRCLCRPGLT GPRCDQCQRG YCNRYPVCVA CHPCFQTYDA DLREQALRFG 600

RLRNATASLW SGPGLEDRGL ASRILDAKSK IEQIRAVLSS PAVTEQEVAQ VASAILSLRR 660

TLQGLQLDLP LEEETLSLPR DLESLDRSFN GLLTMYQRKR EQFEKISSAD PSGAFRMLST 720 AYEQSAQAAQ QVSDSSRLLD QLRDSRREAE RLVRQAGGGG GTGSPKLVAL RLEMSSLPDL 780

TPTFNKLCGN SRQMACTPIS CPGELCPQDN GTACGSRCRG VLPRAGGAFL MAGQVAEQLR 840

GFNAQLQRTR QMIRAAEESA SQIQSSAQRL ETQVSASRSQ MEEDVRRTRL LIQQVRDFLT 900

DPDTDAATIQ EVSEAVLAL LPTDSATVLQ KMNEIQAIAA RLPNVDLVLS QTKQDIARAR 960

RLQAEAEEAR SRAHAVEGQV EDWGNLRQG TVALQEAQDT MQGTSRSLRL IQDRVAEVQQ 1020 VLRPAEKLVT SMTKQLGDFW TRMEELRHQA RQQGAEAVQA QQLAEGASEQ ALSAQEGFER 1080

IKQKYAELKD RLGQSSMLGE QGARIQSVKT EAEELFGETM EMMDRMKDME LELLRGSQAI 1140 MLRSADLTGL EKRVEQIRDH INGRVLYYAT CK

Seq ID NO: 21 DNA sequence Nucleic Acid Accession #: NM_003722 Coding sequence: 145-1491

1 11 21 31 41 51 TCGTTGATAT CAAAGACAGT TGAAGGAAAT GAATTTTGAA ACTTCACGGT GTGCCACCCT 60

ACAGTACTGC CCTGACCCTT ACATCCAGCG TTTCGTAGAA ACCCAGCTCA TTTCTCTTGG 120

AAAGAAAGTT ATTACCGATC CACCATGTCC CAGAGCACAC AGACAAATGA ATTCCTCAGT 180

CCAGAGGTTT TCCAGCATAT CTGGGATTTT CTGGAACAGC CTATATGTTC AGTTCAGCCC 240

ATTGACTTGA ACTTTGTGGA TGAACCATCA GAAGATGGTG CGACAAACAA GATTGAGATT 300 AGCATGGACT GTATCCGCAT GCAGGACTCG GACCTGAGTG ACCCCATGTG GCCACAGTAC 360

ACGAACCTGG GGCTCCTGAA CAGCATGGAC CAGCAGATTC AGAACGGCTC CTCGTCCACC 420

AGTCCCTATA ACACAGACCA CGCGCAGAAC AGCGTCACGG CGCCCTCGCC CTACGCACAG 480

CCCAGCTCCA CCTTCGATGC TCTCTCTCCA TCACCCGCCA TCCCCTCCAA CACCGACTAC 540

CCAGGCCCGC ACAGTTTCGA CGTGTCCTTC CAGCAGTCGA GCACCGCCAA GTCGGCCACC 600 TGGACGTATT CCACTGAACT GAAGAAACTC TACTGCCAAA TTGCAAAGAC ATGCCCCATC 660

CAGATCAAGG TGATGACCCC ACCTCCTCAG GGAGCTGTTA TCCGCGCCAT GCCTGTCTAC 720

AAAAAAGCTG AGCACGTCAC GGAGGTGGTG AAGCGGTGCC CCAACCATGA GCTGAGCCGT 780

GAATTCAACG AGGGACAGAT TGCCCCTCCT AGTCATTTGA TTCGAGTAGA GGGGAACAGC 840

CATGCCCAGT ATGTAGAAGA TCCCATCACA GGAAGACAGA GTGTGCTGGT ACCTTATGAG 900 CCACCCCAGG TTGGCACTGA ATTCACGACA GTCTTGTACA ATTTCATGTG TAACAGCAGT 960

TGTGTTGGAG GGATGAACCG CCGTCCAATT TTAATCATTG TTACTCTGGA AACCAGAGAT 1020

GGGCAAGTCC TGGGCCGACG CTGCTTTGAG GCCCGGATCT GTGCTTGCCC AGGAAGAGAC 1080

AGGAAGGCGG ATGAAGATAG CATCAGAAAG CAGCAAGTTT CGGACAGTAC AAAGAACGGT 1140

GATGGTACGA AGCGCCCGTT TCGTCAGAAC ACACATGGTA TCCAGATGAC ATCCATCAAG 1200 AAACGAAGAT CCCCAGATGA TGAACTGTTA TACTTACCAG TGAGGGGCCG TGAGACTTAT 1260

GAAATGCTGT TGAAGATCAA AGAGTCCCTG GAACTCATGC AGTACCTTCC TCAGCACACA 1320

ATTGAAACGT ACAGGCAACA GCAACAGCAG CAGCACCAGC ACTTACTTCA GAAACATCTC 1380

CTTTCAGCCT GCTTCAGGAA TGAGCTTGTG GAGCCCCGGA GAGAAACTCC AAAACAATCT 1440

GACGTCTTCT TTAGACATTC CAAGCCCCCA AACCGATCAG TGTACCCATA GAGCCCTATC 1500 TCTATATTTT AAGTGTGTGT GTTGTATTTC CATGTGTATA TGTGAGTGTG TGTGTGTGTA 1560

TGTGTGTGCG TGTGTATCTA GCCCTCATAA ACAGGACTTG AAGACACTTT GGCTCAGAGA 1620

CCCAACTGCT CAAAGGCACA AAGCCACTAG TGAGAGAATC TTTTGAAGGG ACTCAAACCT 1680

TTACAAGAAA GGATGTTTTC TGCAGATTTT GTATCCTTAG ACCGGCCATT GGTGGGTGAG 1740

GAACCACTGT GTTTGTCTGT GAGCTTTCTG TTGTTTCCTG GGAGGGAGGG GTCAGGTGGG 1800 GAAAGGGGCA TTAAGATGTT TATTGGAACC CTTTTCTGTC TTCTTCTGTT GTTTTTCTAA 1860

AATTCACAGG GAAGCTTTTG AGCAGGTCTC AAACTTAAGA TGTCTTTTTA AGAAAAGGAG 1920

AAAAAAGTTG TTATTGTCTG TGCATAAGTA AGTTGTAGGT GACTGAGAGA CTCAGTCAGA 1980

CCCTTTTAAT GCTGGTCATG TAATAATATT GCAAGTAGTA AGAAACGAAG GTGTCAAGTG 2040

TACTGCTGGG CAGCGAGGTG ATCATTACCA AAAGTAATCA ACTTTGTGGG TGGAGAGTTC 2100 TTTGTGAGAA CTTGCATTAT TTGTGTCCTC CCCTCATGTG TAGGTAGAAC ATTTCTTAAT 2160

GCTGTGTACC TGCCTCTGCC ACTGTATGTT GGCATCTGTT ATGCTAAAGT TTTTCTTGTA 2220

CATGAAACCC TGGAAGACCT ACTACAAAAA AACTGTTGTT TGGCCCCCAT AGCAGGTGAA 2280

CTCATTTTGT GCTTTTAATA GAAAGACAAA TCCACCCCAG TAATATTGCC CTTACGTAGT 2340

TGTTTACCAT TATTCAAAGC TCAAAATAGA ATTTGAAGCC CTCTCACAAA ATCTGTGATT 2400 AATTTGCTTA ATTAGAGCTT CTATCCCTCA AGCCTACCTA CCATAAAACC AGCCATATTA 2460

CTGATACTGT TCAGTGCATT TAGCCAGGAG ACTTACGTTT TGAGTAAGTG AGATCCAAGC 2520

AGACGTGTTA AAATCAGCAC TCCTGGACTG GAAATTAAAG ATTGAAAGGG TAGACTACTT 2580 TTCTTTTTTT TACTCAAAAG TTTAGAGAAT CTCTGTTTCT TTCCATTTTA AAAACATATT 2640

TTAAGATAAT AGCATAAAGA CTTTAAAAAT GTTCCTCCCC TCCATCTTCC CACACCCAGT 2700

CACCAGCACT GTATTTTCTG TCACCAAGAC AATGATTTCT TGTTATTGAG GCTGTTGCTT 2760 TTGTGGATGT GTGATTTTAA TTTTCAATAA ACTTTTGCAT CTTGGTTTAA AAGAAA

Seq ID NO: 22 Protein sequence: Protein Accession #: NP_003713

1 11 21 31 41 51 I I I I I I

MSQSTQTNEF LSPEVFQHIW DFLEQPICSV QPIDLNFVDE PSEDGATNKI EISMDCIRMQ 60

DSDLSDPM P QYTNLGLLNS MDQQIQNGSS STSPYNTDHA QNSVTAPSPY AQPSSTFDAL 120

SPSPAIPSNT DYPGPHSFDV SFQQSSTAKS ATWTYSTELK KLYCQIAKTC PIQIKVMTPP 180

PQGAVIRAMP VYKKAEHVTE WKRCPNHEL SREFNEGQIA PPSHLIRVEG NSHAQYVEDP 240 ITGRQSVLVP YEPPQVGTEF TTVLYNFMCN SSCVGGMNRR PILIIVTLET RDGQVLGRRC 300

FEARICACPG RDRKADEDSI RKQQVSDSTK NGDGTKRPFR QNTHGIQMTS IKKRRSPDDE 360

LLYLPVRGRE TYEMLLKIKE SLELMQYLPQ HTIETYRQQQ QQQHQHLLQK HLLSACFRNE 420 LVEPRRETPK QSDVFFRHSK PPNRSVYP

Seq ID NO: 23 DNA sequence

Nucleic Acid Accession #: NM_001944.1

Coding sequence: 84-3083

1 11 21 31 41 51

I I I I I I

TTTTCTTAGA CATTAACTGC AGACGGCTGG CAGGATAGAA GCAGCGGCTC ACTTGGACTT 60

TTTCACCAGG GAAATCAGAG ACAATGATGG GGCTCTTCCC CAGAACTACA GGGGCTCTGG 120

CCATCTTCGT GGTGGTCATA TTGGTTCATG GAGAATTGCG AATAGAGACT AAAGGTCAAT 180

ATGATGAAGA AGAGATGACT ATGCAACAAG CTAAAAGAAG GCAAAAACGT GAATGGGTGA 240

AATTTGCCAA ACCCTGCAGA GAAGGAGAAG ATAACTCAAA AAGAAACCCA ATTGCCAAGA 300

TTACTTCAGA TTACCAAGCA ACCCAGAAAA TCACCTACCG AATCTCTGGA GTGGGAATCG 360

ATCAGCCGCC TTTTGGAATC TTTGTTGTTG ACAAAAACAC TGGAGATATT AACATAACAG 420

CTATAGTCGA CCGGGAGGAA ACTCCAAGCT TCCTGATCAC ATGTCGGGCT CTAAATGCCC 480

AAGGACTAGA TGTAGAGAAA CCACTTATAC TAACGGTTAA AATTTTGGAT ATTAATGATA 540

ATCCTCCAGT ATTTTCACAA CAAATTTTCA TGGGTGAAAT TGAAGAAAAT AGTGCCTCAA 600

ACTCACTGGT GATGATACTA AATGCCACAG ATGCAGATGA ACCAAACCAC TTGAATTCTA 660

AAATTGCCTT CAAAATTGTC TCTCAGGAAC CAGCAGGCAC ACCCATGTTC CTCCTAAGCA 720

GAAACACTGG GGAAGTCCGT ACTTTGACCA ATTCTCTTGA CCGAGAGCAA GCTAGCAGCT 780

ATCGTCTGGT TGTGAGTGGT GCAGACAAAG ATGGAGAAGG ACTATCAACT CAATGTGAAT 840

GTAATATTAA AGTGAAAGAT GTCAACGATA ACTTCCCAAT GTTTAGAGAC TCTCAGTATT 900

CAGCACGTAT TGAAGAAAAT ATTTTAAGTT CTGAATTACT TCGATTTCAA GTAACAGATT 960

TGGATGAAGA GTACACAGAT AATTGGCTTG CAGTATATTT CTTTACCTCT GGGAATGAAG 1020

GAAATTGGTT TGAAATACAA ACTGATCCTA GAACTAATGA AGGCATCCTG AAAGTGGTGA 1080

AGGCTCTAGA TTATGAACAA CTACAAAGCG TGAAACTTAG TATTGCTGTC AAAAACAAAG 1140

CTGAATTTCA CCAATCAGTT ATCTCTCGAT ACCGAGTTCA GTCAACCCCA GTCACAATTC 1200

AGGTAATAAA TGTAAGAGAA GGAATTGCAT TCCGTCCTGC TTCCAAGACA TTTACTGTGC 1260

AAAAAGGCAT AAGTAGCAAA AAATTGGTGG ATTATATCCT GGGAACATAT CAAGCCATCG 1320

ATGAGGACAC TAACAAAGCT GCCTCAAATG TCAAATATGT CATGGGACGT AACGATGGTG 1380

GATACCTAAT GATTGATTCA AAAACTGCTG AAATCAAATT TGTCAAAAAT ATGAACCGAG 1440

ATTCTACTTT CATAGTTAAC AAAACAATCA CAGCTGAGGT TCTGGCCATA GATGAATACA 1500

CGGGTAAAAC TTCTACAGGC ACGGTATATG TTAGAGTACC CGATTTCAAT GACAATTGTC 1560

CAACAGCTGT CCTCGAAAAA GATGCAGTTT GCAGTTCTTC ACCTTCCGTG GTTGTCTCCG 1620

CTAGAACACT GAATAATAGA TACACTGGCC CCTATACATT TGCACTGGAA GATCAACCTG 1680

TAAAGTTGCC TGCCGTATGG AGTATCACAA CCCTCAATGC TACCTCGGCC CTCCTCAGAG 1740

CCCAGGAACA GATACCTCCT GGAGTATACC ACATCTCCCT GGTACTTACA GACAGTCAGA 1800

ACAATCGGTG TGAGATGCCA CGCAGCTTGA CACTGGAAGT CTGTCAGTGT GACAACAGGG 1860

GCATCTGTGG AACTTCTTAC CCAACCACAA GCCCTGGGAC CAGGTATGGC AGGCCGCACT 1920

CAGGGAGGCT GGGGCCTGCC GCCATCGGCC TGCTGCTCCT TGGTCTCCTG CTGCTGCTGT 1980

TGGCCCCCCT TCTGCTGTTG ACCTGTGACT GTGGGGCAGG TTCTACTGGG GGAGTGACAG 2040

GTGGTTTTAT CCCAGTTCCT GATGGCTCAG AAGGAACAAT TCATCAGTGG GGAATTGAAG 2100

GAGCCCATCC TGAAGACAAG GAAATCACAA ATATTTGTGT GCCTCCTGTA ACAGCCAATG 2160

GAGCCGATTT CATGGAAAGT TCTGAAGTTT GTACAAATAC GTATGCCAGA GGCACAGCGG 2220

TGGAAGGCAC TTCAGGAATG GAAATGACCA CTAAGCTTGG AGCAGCCACT GAATCTGGAG 2280

GTGCTGCAGG CTTTGCAACA GGGACAGTGT CAGGAGCTGC TTCAGGATTC GGAGCAGCCA 2340

CTGGAGTTGG CATCTGTTCC TCAGGGCAGT CTGGAACCAT GAGAACAAGG CATTCCACTG 2400

GAGGAACCAA TAAGGACTAC GCTGATGGGG CGATAAGCAT GAATTTTCTG GACTCCTACT 2460

TTTCTCAGAA AGCATTTGCC TGTGCGGAGG AAGACGATGG CCAGGAAGCA AATGACTGCT 2520

TGTTGATCTA TGATAATGAA GGCGCAGATG CCACTGGTTC TCCTGTGGGC TCCGTGGGTT 2580

GTTGCAGTTT TATTGCTGAT GACCTGGATG ACAGCTTCTT GGACTCACTT GGACCCAAAT 2640

TTAAAAAACT TGCAGAGATA AGCCTTGGTG TTGATGGTGA AGGCAAAGAA GTTCAGCCAC 2700

CCTCTAAAGA CAGCGGTTAT GGGATTGAAT CCTGTGGCCA TCCCATAGAA GTCCAGCAGA 2760

CAGGATTTGT TAAGTGCCAG ACTTTGTCAG GAAGTCAAGG AGCTTCTGCT TTGTCCGCCT 2820

CTGGGTCTGT CCAGCCAGCT GTTTCCATCC CTGACCCTCT GCAGCATGGT AACTATTTAG 2880

TAACGGAGAC TTACTCGGCT TCTGGTTCCG TCGTGCAACC TTCCACTGCA GGCTTTGATC 2940

CACTTCTCAC ACAAAATGTG ATAGTGACAG AAAGGGTGAT CTGTCCCATT TCCAGTGTTC 3000

CTGGCAACCT AGCTGGCCCA ACGCAGCTAC GAGGGTCACA TACTATGCTC TGTACAGAGG 3060

ATCCTTGCTC CCGTCTAATA TGACCAGAAT GAGCTGGAAT ACCACACTGA CCAAATCTGG 3120

ATCTTTGGAC TAAAGTATTC AAAATAGCAT AGCAAAGCTC ACTGTATTGG GCTAATAATT 3180

TGGCACTTAT TAGCTTCTCT CATAAACTGA TCACGATTAT AAATTAAATG TTTGGGTTCA 3240

TACCCCAAAA GCAATATGTT GTCACTCCTA ATTCTCAAGT ACTATTCAAA TTGTAGTAAA 3300 TCTTAAAGTT TTTCAAAACC CTAAAATCAT ATTCGC

Seq ID NO: 24 Protein sequence: Protein Accession #: NP_001935.1

1 11 21 31 41 51 MMGLFPRTTG ALAIFVWIL VHGELRIETK GQYDEEEMTM QQAKRRQKRE WVKFAKPCRE 60

GEDNSKRNPI AKITSDYQAT QKITYRISGV GIDQPPFGIF WDKNTGDIN ITAIVDREET 120

PSFLITCRAL NAQGLDVEKP LILTVKILDI NDNPPVFSQQ IFMGEIEENS ASNSLVMILN 180

ATDADEPNHL NSKIAFKIVS QEPAGTPMFL LSRNTGEVRT LTNSLDREQA SSYRLWSGA 240

DKDGEGLSTQ CECNIKVKDV NDNFPMFRDS QYSARIEENI LSSELLRFQV TDLDEEYTDN 300 LAVYFFTSG NEGNWFEIQT DPRTNEGILK WKALDYEQL QSVKLSIAVK NKAEFHQSVI 360

SRYRVQSTPV TIQVINVREG IAFRPASKTF TVQKGISSKK LVDYILGTYQ AIDEDTNKAA 420

SNVKYVMGRN DGGYLMIDSK TAEIKFVKNM NRDSTFIVNK TITAEVLAID EYTGKTSTGT 480

VYVRVPDFND NCPTAVLEKD AVCSSSPSW VSARTLNNRY TGPYTFALED QPVKLPAVWS 540

ITTLNATSAL LRAQEQIPPG VYHISLVLTD SQNNRCEMPR SLTLEVCQCD NRGICGTSYP 600

TTSPGTRYGR PHSGRLGPAA IGLLLLGLLL LLLAPLLLLT CDCGAGSTGG VTGGFIPVPD 660

GSEGTIHQWG IEGAHPEDKE ITNICVPPVT ANGADFMESS EVCTNTYARG TAVEGTSGME 720

MTTKLGAATE SGGAAGFATG TVSGAASGFG AATGVGICSS GQSGTMRTRH STGGTNKDYA 780

DGAISMNFLD SYFSQKAFAC AEEDDGQEAN DCLLIYDNEG ADATGSPVGS VGCCSFIADD 840

LDDSFLDSLG PKFKKLAEIS LGVDGEGKEV QPPSKDSGYG IESCGHPIEV QQTGFVKCQT 900

LSGSQGASAL SASGSVQPAV SIPDPLQHGN YLVTETYSAS GSLVQPSTAG FDPLLTQNVI 960 VTERVICPIS SVPGNLAGPT QLRGSHTMLC TEDPCSRLI

Seq ID NO: 25 DNA sequence

Nucleic Acid Accession #: Eos sequence

Coding sequence: 56-1642 1 11 21 31 41 51 i i i i i i

AGTATCCCAG GAGGAGCAAG TGGCACGTCT TCGGACCTAG GCTGCCCCTG CCGTCATGTC 60

GCAAGGGATC CTTTCTCCGC CAGCGGGCTT GCTGTCCGAT GACGATGTCG TAGTTTCTCC 120

CATGTTTGAG TCCACAGCTG CAGATTTGGG GTCTGTGGTA CGCAAGAACC TGCTATCAGA 180

CTGCTCTGTC GTCTCTACCT CCCTAGAGGA CAAGCAGCAG GTTCCATCTG AGGACAGTAT 240

GGAGAAGGTG AAAGTATACT TGAGGGTTAG GCCCTTGTTA CCTTCAGAGT TGGAACGACA 300

GGAAGATCAG GGTTGTGTCC GTATTGAGAA TGTGGAGACC CTTGTTCTAC AAGCACCCAA 360

GGACTCTTTT GCCCTGAAGA GCAATGAACG GGGAATTGGC CAAGCCACAC ACAGGTTCAC 420

CTTTTCCCAG ATCTTTGGGC CAGAAGTGGG ACAGGCATCC TTCTTCAACC TAACTGTGAA 480

GGAGATGGTA AAGGATGTAC TCAAAGGGCA GAACTGGCTC ATCTATACAT ATGGAGTCAC 540

TAACTCAGGG AAAACCCACA CGATTCAAGG TACCATCAAG GATGGAGGGA TTCTCCCCCG 600

GTCCCTGGCG CTGATCTTCA ATAGCCTCCA AGGCCAACTT CATCCAACAC CTGATCTGAA 660

GCCCTTGCTC TCCAATGAGG TAATCTGGCT AGACAGCAAG CAGATCCGAC AGGAGGAAAT 720

GAAGAAGCTG TCCCTGCTAA ATGGAGGCCT CCAAGAGGAG GAGCTGTCCA CTTCCTTGAA 780

GAGGAGTGTC TACATCGAAA GTCGGATAGG TACCAGCACC AGCTTCGACA GTGGCATTGC 840

TGGGCTCTCT TCTATCAGTC AGTGTACCAG CAGTAGCCAG CTGGATGAAA CAAGTCATCG 900

ATGGGCACAG CCAGACACTG CCCCACTACC TGTCCCGGCA AACATTCGCT TCTCCATCTG 960

GATCTCATTC TTTGAGATCT ACAACGAACT GCTTTATGAC CTATTAGAAC CGCCTAGCCA 1020

ACAGCGCAAG AGGCAGACTT TGCGGCTATG CGAGGATCAA AATGGCAATC CCTATGTGAA 1080

AGATCTCAAC TGGATTCATG TGCAAGATGC TGAGGAGGCC TGGAAGCTCC TAAAAGTGGG 1140

TCGTAAGAAC CAGAGCTTTG CCAGCACCCA CCTCAACCAG AACTCCAGCC GCAGTCACAG 1200

CATCTTCTCA ATCAGGATCC TACACCTTCA GGGGGAAGGA GATATAGTCC CCAAGATCAG 1260

CGAGCTGTCA CTCTGTGATC TGGCTGGCTC AGAGCGCTGC AAAGATCAGA AGAGTGGTGA 1320

ACGGTTGAAG GAAGCAGGAA ACATTAACAC CTCTCTACAC ACCCTGGGCC GCTGTATTGC 1380

TGCCCTTCGT CAAAACCAGC AGAACCGGTC AAAGCAGAAC CTGGTTCCCT TCCGTGACAG 1440

CAAGTTGACT CGAGTGTTCC AAGGTTTCTT CACAGGCCGA GGCCGTTCCT GCATGATTGT 1500

CAATGTGAAT CCCTGTGCAT CTACCTATGA TGAAACTCTT CATGTGGCCA AGTTCTCAGC 1560

CATTGCTAGC CAGGTGACTT GTGCATGCCC CACCTATGCA ACTGGGATTC CCATCCCTGC 1620

ACTCGTTCAT CAAGGAACAT AGTCTTCAGG TATCCCCCAG CTTAGAGAAA GGGGCTAAGG 1680

CAGACACAGG CCTTGATGAT GATATTGAAA ATGAAGCTGA CATCTCCATG TATGGCAAAG 1740

AGGAGCTCCT ACAAGTTGTG GAAGCCATGA AGACACTGCT TTTGAAGGAA CGACAGGAAA 1800

AGCTACAGCT GGAGATGCAT CTCCGAGATG AAATTTGCAA TGAGATGGTA GAACAGATGC 1860

AACAGCGGGA ACAGTGGTGC AGTGAACATT TGGACACCCA AAAGGAACTA TTGGAGGAAA 1920

TGTATGAAGA AAAACTAAAT ATCCTCAAGG AGTCACTGAC AAGTTTTTAC CAAGAAGAGA 1980

TTCAGGAGCG GGATGAAAAG ATTGAAGAGC TAGAAGCTCT CTTGCAGGAA GCCAGACAAC 2040

AGTCAGTGGC CCATCAGCAA TCAGGGTCTG AATTGGCCCT ACGGCGGTCA CAAAGGTTGG 2100

CAGCTTCTGC CTCCACCCAG CAGCTTCAGG AGGTTAAAGC TAAATTACAG CAGTGCAAAG 2160

CAGAGCTAAA CTCTACCACT GAAGAGTTGC ATAAGTATCA GAAAATGTTA GAACCACCAC 2220

CCTCAGCCAA GCCCTTCACC ATTGATGTGG ACAAGAAGTT AGAAGAGGGC CAGAAGAATA 2280

TAAGGCTGTT GCGGACAGAG CTTCAGAAAC TTGGTGAGTC TCTCCAATCA GCAGAGAGAG 2340

CTTGTTGCCA CAGCACTGGG GCAGGAAAAC TTCGTCAAGC CTTGACCACT TGTGATGACA 2400

TCTTAATCAA ACAGGACCAG ACTCTGGCTG AACTGCAGAA CAACATGGTG CTAGTGAAAC 2460

TGGACCTTCG GAAGAAGGCA GCATGTATTG CTGAGCAGTA TCATACTGTG TTGAAACTCC 2520

AAGGCCAGGT TTCTGCCAAA AAGCGCCTTG GTACCAACCA GGAAAATCAG CAACCAAACC 2580

AACAACCACC AGGGAAGAAA CCATTCCTTC GAAATTTACT TCCCCGAACA CCAACCTGCC 2640

AAAGCTCAAC AGACTGCAGC CCTTATGCCC GGATCCTACG CTCACGGCGT TCCCCTTTAC 2700

TCAAATCTGG GCCTTTTGGC AAAAAGTACT AAGGCTGTGG GGAAAGAGAA GAGCAGTCAT 2760

GGCCCTGAGG TGGGTCAGCT ACTCTCCTGA AGAAATAGGT CTCTTTTATG CTTTACCATA 2820

TATCAGGAAT TATATCCAGG ATGCAATACT CAGACACTAG CTTTTTTCTC ACTTTTGTAT 2880

TATAACCACC TATGTAATCT CATGTTGTTG TTTTTTTTTA TTTACTTATA TGATTTCTAT 2940

GCACACAAAA ACAGTTATAT TAAAGATATT ATTGTTCACA TTTTTTATTG AATTCCAAAT 3000 GTAGCAAAAT CATTAAAACA AATTATAAAA GGGACAGAAA AA

Seq ID NO: 26 Protein sequence: Protein Accession # : Eos sequence

1 11 21 31 41 51

1 I I I I I

MSQGILSPPA GLLSDDDVW SPMFESTAAD LGSWRKNLL SDCSWSTSL EDKQQVPSED 60

SMEKVKVYLR VRPLLPSELE RQEDQGCVRI ENVETLVLQA PKDSFALKSN ERGIGQATHR 120

FTFSQIFGPE VGQASFFNLT VKEMVKDVLK GQNWLIYTYG VTNSGKTHTI QGTIKDGGIL 180

PRSLALIFNS LQGQLHPTPD LKPLLSNEVI WLDSKQIRQE EMKKLSLLNG GLQEEELSTS 240

LKRSVYIESR IGTSTSFDSG IAGLSSISQC TSSSQLDETS HRWAQPDTAP LPVPANIRFS 300 IWISFFEIYN ELLYDLLEPP SQQRKRQTLR LCEDQNGNPY VKDLNWIHVQ DAEEAWKLLK 360 VGRKNQSFAS THLNQNSSRS HSIFSIRILH LQGEGDIVPK ISELSLCDLA GSERCKDQKS 420 GERLKEAGNI NTSLHTLGRC IAALRQNQQN RSKQNLVPFR DSKLTRVFQG FFTGRGRSCM 480 IVNVNPCAST YDETLHVAKF SAIASQVTCA CPTYATGIPI PALVHQGT

Seq ID NO: 27 DNA sequence

Nucleic Acid Accession #: Eos sequence

Coding sequence: 13-1424

11 21 31 41 51

TAGAAGTTTA CAATGAAGTT TCTTCTAATA CTGCTCCTGC AGGCCACTGC TTCTGGAGCT 60 CTTCCCCTGA ACAGCTCTAC AAGCCTGGAA AAAAATAATG TGCTATTTGG TGAAAGATAC 120 TTAGAAAAAT TTTATGGCCT TGAGATAAAC AAACTTCCAG TGACAAAAAT GAAATATAGT 180 GGAAACTTAA TGAAGGAAAA AATCCAAGAA ATGCAGCACT TCTTGGGTCT GAAAGTGACC 240 GGGCAACTGG ACACATCTAC CCTGGAGATG ATGCACGCAC CTCGATGTGG AGTCCCCGAT 300 GTCCATCATT TCAGGGAAAT GCCAGGGGGG CCCGTATGGA GGAAACATTA TATCACCTAC 360 AGAATCAATA ATTACACACC TGACATGAAC CGTGAGGATG TTGACTACGC AATCCGGAAA 420 GCTTTCCAAG TATGGAGTAA TGTTACCCCC TTGAAATTCA GCAAGATTAA CACAGGCATG 480 GCTGACATTT TGGTGGTTTT TGCCCGTGGA GCTCATGGAG ACTTCCATGC TTTTGATGGC 540 AAAGGTGGAA TCCTAGCCCA TGCTTTTGGA CCTGGATCTG GCATTGGAGG GGATGCACAT 600 TTCGATGAGG ACGAATTCTG GACTACACAT TCAGGAGGCA CAAACTTGTT CCTCACTGCT 660 GTTCACGAGA TTGGCCATTC CTTAGGTCTT GGCCATTCTA GTGATCCAAA GGCCGTAATG 720 TTCCCCACCT ACAAATATGT TGACATCAAC ACATTTCGCC TCTCTGCTGA TGACATACGT 780 GGCATTCAGT CCCTGTATGG AGACCCAAAA GAGAACCAAC GCTTGCCAAA TCCTGACAAT 840 TCAGAACCAG CTCTCTGTGA CCCCAATTTG AGTTTTGATG CTGTCACTAC CGTGGGAAAT 900 AAGATCTTTT TCTTCAAAGA CAGGTTCTTC TGGCTGAAGG TTTCTGAGAG ACCAAAGACC 960 AGTGTTAATT TAATTTCTTC CTTATGGCCA ACCTTGCCAT CTGGCATTGA AGCTGCTTAT 1020 GAAATTGAAG CCAGAAATCA AGTTTTTCTT TTTAAAGATG ACAAATACTG GTTAATTAGC 1080 AATTTAAGAC CAGAGCCAAA TTATCCCAAG AGCATACATT CTTTTGGTTT TCCTAACTTT 1140 GTGAAAAAAA TTGATGCAGC TGTTTTTAAC CCACGTTTTT ATAGGACCTA CTTCTTTGTA 1200 GATAACCAGT ATTGGAGGTA TGATGAAAGG AGACAGATGA TGGACCCTGG TTATCCCAAA 1260 CTGATTACCA AGAACTTCCA AGGAATCGGG CCTAAAATTG ATGCAGTCTT CTACTCTAAA 1320 AACAAATACT ACTATTTCTT CCAAGGATCT AACCAATTTG AATATGACTT CCTACTCCAA 1380 CGTATCACCA AAACACTGAA AAGCAATAGC TGGTTTGGTT GTTGAAAATG GTGTAATTAA 1440 TGGTTTTTGT TAGTTCACTT CAGCTTAATA AGTATTTATT GCATATTTGC TATGTCCTCA 1500 GTGTACCACT ACTTAGAGAT ATGTATCATA AAAATAAAAT CTGTAAACCA TAGGTAATGA 1560 TTATATAAAA TACATAATAT TTTTCAATTT TGAAAACTCT AATTGTCCAT TCTTGCTTGA 1620 CTCTACTATT AAGTTTGAAA ATAGTTACCT TCAAAGCAAG ATAATTCTAT TTGAAGCATG 1680 CTCTGTAAGT TGCTTCCTAA CATCCTTGGA CTGAGAAATT ATACTTACTT CTGGCATAAC 1740 TAAAATTAAG TATATATATT TTGGCTCAAA TAAAATTG

Seq ID NO: 28 Protein sequence: Protein Accession #: Eos sequence

11 21 31 41 51

I I I I

MKFL I LLQ ATASGALPLN S 1STSLEKNNV LFGERYLEKF YGLEINKLPV TKMKYSGNLM 60 KEKIQEMQHF LGLKVTGQLD TSTLEMMHAP RCGVPDVHHF REMPGGPV R KHYITYRINN 120 YTPDMNREDV DYAIRKAFQV SNVTPLKFS KINTGMADIL WFARGAHGD FHAFDGKGGI 180 LAHAFGPGSG IGGDAHFDED EFWTTHSGGT NLFLTAVHEI GHSLGLGHSS DPKAVMFPTY 240 KYVDINTFRL SADDIRGIQS LYGDPKENQR LPNPDNSEPA LCDPNLSFDA VTTVGNKIFF 300 FKDRFFWLKV SERPKTSVNL ISSLWPTLPS GIEAAYEIEA RNQVFLFKDD KYWLISNLRP 360 EPNYPKSIHS FGFPNFVKKI DAAVFNPRFY RTYFFVDNQY RYDERRQMM DPGYPKLITK 420 NFQGIGPKID AVFYSKNKYY YFFQGSNQFE YDFLLQRITK TLKSNSWFGC

Seq ID NO: 29 DNA sequence

Nucleic Acid Accession #: NM_006115.1

Coding sequence: 236..1765

11 21 31 41 51

GCTTCAGGGT ACAGCTCCCC CGCAGCCAGA AGCCGGGCCT GCAGCCCCTC AGCACCGCTC 60 CGGGACACCC CACCCGCTTC CCAGGCGTGA CCTGTCAACA GCAACTTCGC GGTGTGGTGA 120 ACTCTCTGAG GAAAAACCAT TTTGATTATT ACTCTCAGAC GTGCGTGGCA ACAAGTGACT 180 GAGACCTAGA AATCCAAGCG TTGGAGGTCC TGAGGCCAGC CTAAGTCGCT TCAAAATGGA 240 ACGAAGGCGT TTGTGGGGTT CCATTCAGAG CCGATACATC AGCATGAGTG TGTGGACAAG 300 CCCACGGAGA CTTGTGGAGC TGGCAGGGCA GAGCCTGCTG AAGGATGAGG CCCTGGCCAT 360 TGCCGCCCTG GAGTTGCTGC CCAGGGAGCT CTTCCCGCCA CTCTTCATGG CAGCCTTTGA 420 CGGGAGACAC AGCCAGACCC TGAAGGCAAT GGTGCAGGCC TGGCCCTTCA CCTGCCTCCC 480 TCTGGGAGTG CTGATGAAGG GACAACATCT TCACCTGGAG ACCTTCAAAG CTGTGCTTGA 540 TGGACTTGAT GTGCTCCTTG CCCAGGAGGT TCGCCCCAGG AGGTGGAAAC TTCAAGTGCT 600 GGATTTACGG AAGAACTCTC ATCAGGACTT CTGGACTGTA TGGTCTGGAA ACAGGGCCAG 660 TCTGTACTCA TTTCCAGAGC CAGAAGCAGC TCAGCCCATG ACAAAGAAGC GAAAAGTAGA 720 TGGTTTGAGC ACAGAGGCAG AGCAGCCCTT CATTCCAGTA GAGGTGCTCG TAGACCTGTT 780 CCTCAAGGAA GGTGCCTGTG ATGAATTGTT CTCCTACCTC ATTGAGAAAG TGAAGCGAAA 840 GAAAAATGTA CTACGCCTGT GCTGTAAGAA GCTGAAGATT TTTGCAATGC CCATGCAGGA 900 TATCAAGATG ATCCTGAAAA TGGTGCAGCT GGACTCTATT GAAGATTTGG AAGTGACTTG 960 TACCTGGAAG CTACCCACCT TGGCGAAATT TTCTCCTTAC CTGGGCCAGA TGATTAATCT 1020 GCGTAGACTC CTCCTCTCCC ACATCCATGC ATCTTCCTAC ATTTCCCCGG AGAAGGAAGA 1080 GCAGTATATC GCCCAGTTCA CCTCTCAGTT CCTCAGTCTG CAGTGCCTGC AGGCTCTCTA 1140 TGTGGACTCT TTATTTTTCC TTAGAGGCCG CCTGGATCAG TTGCTCAGGC ACGTGATGAA 1200 CCCCTTGGAA ACCCTCTCAA TAACTAACTG CCGGCTTTCG GAAGGGGATG TGATGCATCT 1260 GTCCCAGAGT CCCAGCGTCA GTCAGCTAAG TGTCCTGAGT CTAAGTGGGG TCATGCTGAC 1320 CGATGΓAAGΓ CCCGAGCCCC TCCAAGCTCT GCTGGAGAGA GCCTCTGCCA CCCTCCAGGA 1380 CCTGGTCTTT GATGAGTGTG GGATCACGGA TGATCAGCTC CTTGCCCTCC TGCCTTCCCT 1440 GAGCCACTGC TCCCAGCTTA CAACCTTAAG CTTCTACGGG AATTCCATCT CCATATCTGC 1500 CTTGCAGAGT CTCCTGCAGC ACCTCATCGG GCTGAGCAAT CTGACCCACG TGCTGTATCC 1560

TGTCCCCCTG GAGAGTTATG AGGACATCCA TGGTACCCTC CACCTGGAGA GGCTTGCCTA 1620

TCTGCATGCC AGGCTCAGGG AGTTGCTGTG TGAGTTGGGG CGGCCCAGCA TGGTCTGGCT 1680

TAGTGCCAAC CCCTGTCCTC ACTGTGGGGA CAGAACCTTC TATGACCCGG AGCCCATCCT 1740

GTGCCCCTGT TTCATGCCTA ACTAGCTGGG TGCACATATC AAATGCTTCA TTCTGCATAC 1800

TTGGACACTA AAGCCAGGAT GTGCATGCAT CTTGAAGCAA CAAAGCAGCC ACAGTTTCAG 1860

ACAAATGTTC AGTGTGAGTG AGGAAAACAT GTTCAGTGAG GAAAAAACAT TCAGACAAAT 1920

GTTCAGTGAG GAAAAAAAGG GGAAGTTGGG GATAGGCAGA TGTTGACTTG AGGAGTTAAT 1980

GTGATCTTTG GGGAGATACA TCTTATAGAG TTAGAAATAG AATCTGAATT TCTAAAGGGA 2040

GATTCTGGCT TGGGAAGTAC ATGTAGGAGT TAATCCCTGT GTAGACTGTT GTAAAGAAAC 2100 TGTTGAAAAT AAAGAGAAGC AATGTGAAGC AAAAAAAAAA AAAAAAAA

Seq ID NO: 30 Protein sequence: Protein Accession #: NP_006106.1

1 11 21 31 41 51

I I I I I I

GCTTCAGGGT ACAGCTCCCC CGCAGCCAGA AGCCGGGCCT GCAGCGCCTC AGCACCGCTC 60

CGGGACACCC CACCCGCTTC CCAGGCGTGA CCTGTCAACA GCAACTTCGC GGTGTGGTGA 120

ACTCTCTGAG GAAAAACCAT TTTGATTATT ACTCTCAGAC GTGCGTGGCA ACAAGTGACT 180

GAGACCTAGA AATCCAAGCG TTGGAGGTCC TGAGGCCAGC CTAAGTCGCT TCAAAATGGA 240

ACGAAGGCGT TTGTGGGGTT CCATTCAGAG CCGATACATC AGCATGAGTG TGTGGACAAG 300

CCCACGGAGA CTTGTGGAGC TGGCAGGGCA GAGCCTGCTG AAGGATGAGG CCCTGGCCAT 360

TGCCGCCCTG GAGTTGCTGC CCAGGGAGCT CTTCCCGCCA CTCTTCATGG CAGCCTTTGA 420

CGGGAGACAC AGCCAGACCC TGAAGGCAAT GGTGCAGGCC TGGCCCTTCA CCTGCCTCCC 480

TCTGGGAGTG CTGATGAAGG GACAACATCT TCAGCTGGAG ACCTTCAAAG CTGTGCTTGA 540

TGGACTTGAT GTGCTCCTTG CCCAGGAGGT TCGCCCCAGG AGGTGGAAAC TTCAAGTGCT 600

GGATTTACGG AAGAACTCTC ATCAGGACTT CTGGACTGTA TGGTCTGGAA ACAGGGCCAG 660

TCTGTACTCA TTTCCAGAGC CAGAAGCAGC TCAGCCCATG ACAAAGAAGC GAAAAGTAGA 720

TGGTTTGAGC ACAGAGGCAG AGCAGCCCTT CATTCCAGTA GAGGTGCTCG TAGACCTGTT 780

CCTCAAGGAA GGTGCCTGTG ATGAATTGTT CTCCTACCTC ATTGAGAAAG TGAAGCGAAA 840

GAAAAATGTA CTACGCCTGT GCTGTAAGAA GCTGAAGATT TTTGCAATGC CCATGCAGGA 900

TATCAAGATG ATCCTGAAAA TGGTGCAGCT GGACTCTATT GAAGATTTGG AAGTGACTTG 960

TACCTGGAAG CTACCCACCT TGGCGAAATT TTCTCCTTAC CTGGGCCAGA TGATTAATCT 1020

GCGTAGACTC CTCCTCTCCC ACATCCATGC ATCTTCCTAC ATTTCCCCGG AGAAGGAAGA 1080

GCAGTATATC GCCCAGTTCA CCTCTCAGTT CCTCAGTCTG CAGTGCCTGC AGGCTCTCTA 1140

TGTGGACTCT TTATTTTTCC TTAGAGGCCG CCTGGATCAG TTGCTCAGGC ACGTGATGAA 1200

CCCCTTGGAA ACCCTCTCAA TAACTAACTG CCGGCTTTCG GAAGGGGATG TGATGCATCT 1260

GTCCCAGAGT CCCAGCGTCA GTCAGCTAAG TGTCCTGAGT CTAAGTGGGG TCATGCTGAC 1320

CGATGTAAGT CCCGAGCCCC TCCAAGCTCT GCTGGAGAGA GCCTCTGCCA CCCTCCAGGA 1380

CCTGGTCTTT GATGAGTGTG GGATCACGGA TGATCAGCTC CTTGCCCTCC TGCCTTCCCT 1440

GAGCCACTGC TCCCAGCTTA CAACCTTAAG CTTCTACGGG AATTCCATCT CCATATCTGC 1500

CTTGCAGAGT CTCCTGCAGC ACCTCATCGG GCTGAGCAAT CTGACCCACG TGCTGTATCC 1560

TGTCCCCCTG GAGAGTTATG AGGACATCCA TGGTACCCTC CACCTGGAGA GGCTTGCCTA 1620

TCTGCATGCC AGGCTCAGGG AGTTGCTGTG TGAGTTGGGG CGGCCCAGCA TGGTCTGGCT 1680

TAGTGCCAAC CCCTGTCCTC ACTGTGGGGA CAGAACCTTC TATGACCCGG AGCCCATCCT 1740

GTGCCCCTGT TTCATGCCTA ACTAGCTGGG TGCACATATC AAATGCTTCA TTCTGCATAC 1800

TTGGACACTA AAGCCAGGAT GTGCATGCAT CTTGAAGCAA CAAAGCAGCC ACAGTTTCAG 1860

ACAAATGTTC AGTGTGAGTG AGGAAAACAT GTTCAGTGAG GAAAAAACAT TCAGACAAAT 1920

GTTCAGTGAG GAAAAAAAGG GGAAGTTGGG GATAGGCAGA TGTTGACTTG AGGAGTTAAT 1980

GTGATCTTTG GGGAGATACA TCTTATAGAG TTAGAAATAG AATCTGAATT TCTAAAGGGA 2040

GATTCTGGCT TGGGAAGTAC ATGTAGGAGT TAATCCCTGT GTAGACTGTT GTAAAGAAAC 2100 TGTTGAAAAT AAAGAGAAGC AATGTGAAGC AAAAAAAAAA AAAAAAAA

Seq ID NO: 31 DNA sequence

Nucleic Acid Accession if: Eos sequence

Coding sequence: 64-2754

1 11 21 31 41 51

I I 1 I 1 1 ^'

GGCAGGTCTC GCTCTCGGCA CCCTCCCGGC GCCCGCGTTC TCCTGGCCCT GCCCGGCATC 60

CCGATGGCCG CCGCTGGGCC CCGGCGCTCC GTGCGCGGAG CCGTCTGCCT GCATCTGCTG 120

CTGACCCTCG TGATCTTCAG TCGTGATGGT GAAGCCTGCA AAAAGGTGAT ACTTAATGTA 180

CCTTCTAAAC TAGAGGCAGA CAAAATAATT GGCAGAGTTA ATTTGGAAGA GTGCTTCAGG 240

TCTGCAGACC TCATCCGGTC AAGTGATCCT GATTTCAGAG TTCTAAATGA TGGGTCAGTG 300

TACACAGCCA GGGCTGTTGC GCTGTCTGAT AAGAAAAGAT CATTTACCAT ATGGCTTTCT 360

GACAAAAGGA AACAGACACA GAAAGAGGTT ACTGTGCTGC TAGAACATCA GAAGAAGGTA 420

TCGAAGACAA GACACACTAG AGAAACTGTT CTCAGGCGTG CCAAGAGGAG ATGGGCACCT 480

ATTCCTTGCT CTATGCAAGA GAATTCCTTG GGCCCTTTCC CATTGTTTCT TCAACAAGTT 540

GAATCTGATG CAGCACAGAA CTATACTGTC TTCTACTCAA TAAGTGGACG TGGAGTTGAT 600

AAAGAACCTT TAAATTTGTT TTATATAGAA AGAGACACTG GAAATCTATT TTGCACTCGG 660

CCTGTGGATC GTGAAGAATA TGATGTTTTT GATTTGATTG CTTATGCGTC AACTGCAGAT 720

GGATATTCAG CAGATCTGCC CCTCCCACTA CCCATCAGGG TAGAGGATGA AAATGACAAC 780

CACCCTGTTT TCACAGAAGC AATTTATAAT TTTGAAGTTT TGGAAAGTAG TAGACCTGGT 840

ACTACAGTGG GGGTGGTTTG TGCCACAGAC AGAGATGAAC CGGACACAAT GCATACGCGC 900

CTGAAATACA GCATTTTGCA GCAGACACCA AGGTCACCTG GGCTCTTTTC TGTGCATCCC 960

AGCACAGGCG TAATCACCAC AGTCTCTCAT TATTTGGACA GAGAGGTTGT AGACAAGTAC 1020

TCATTGATAA TGAAAGTACA AGACATGGAT GGCCAGTTTT TTGGATTGAT AGGCACATCA 1080

ACTTGTATCA TAACAGTAAC AGATTCAAAT GATAATGCAC CCACTTTCAG ACAAAATGCT 1140

TATGAAGCAT TTGTAGAGGA AAATGCATTC AATGTGGAAA TCTTACGAAT ACCTATAGAA 1200

GATAAGGATT TAATTAACAC TGCCAATTGG AGAGTCAATT TTACCATTTT AAAGGGAAAT 1260

GAAAATGGAC ATTTCAAAAT CAGCACAGAC AAAGAAACTA ATGAAGGTGT TCTTTCTGTT 1320

GTAAAGCCAC TGAATTATGA AGAAAACCGT CAAGTGAACC TGGAAATTGG AGTAAACAAT 1380

GAAGCGCCAT TTGCTAGAGA TATTCCCAGA GTGACAGCCT TGAACAGAGC CTTGGTTACA 1440

GTTCATGTGA GGGATCTGGA TGAGGGGCCT GAATGCACTC CTGCAGCCCA ATATGTGCGG 1500

ATTAAAGAAA ACTTAGCAGT GGGGTCAAAG ATCAACGGCT ATAAGGCATA TGACCCCGAA 1560 AATAGAAATG GCAATGGTTT AAGGTACAAA AAATTGCATG ATCCTAAAGG TTGGATCACC 1620 ATTGATGAAA TTTCAGGGTC AATCATAACT TCCAAAATCC TGGATAGGGA GGTTGAAACT 1680 CCCAAAAATG AGTTGTATAA TATTACAGTC CTGGCAATAG ACAAAGATGA TAGATCATGT 1740 ACTGGAACAC TTGCTGTGAA CATTGAAGAT GTAAATGATA ATCCACCAGA AATACTTCAA 1800 GAATATGTAG TCATTTGCAA ACCAAAAATG GGGTATACCG ACATTTTAGC TGTTGATCCT 1860 GATGAACCTG TCCATGGAGC TCCATTTTAT TTCAGTTTGC CCAATACTTC TCCAGAAATC 1920 AGTAGACTGT GGAGCCTCAC CAAAGTTAAT GATACAGCTG CCCGTCTTTC ATATCAGAAA 1980 AATGCTGGAT TTCAAGAATA TACCATTCCT ATTACTGTAA AAGACAGGGC CGGCCAAGCT 2040 GCAACAAAAT TATTGAGAGT TAATCTGTGT GAATGTACTC ATCCAACTCA GTGTCGTGCG 2100 ACTTCAAGGA GTACAGGAGT AATACTTGGA AAATGGGCAA TCCTTGCAAT ATTACTGGGT 2160 ATAGCACTGC TCTTTTCTGT ATTGCTAACT TTAGTATGTG GAGTTTTTGG TGCAACTAAA 2220 GGGAAACGTT TTCCTGAAGA TTTAGCACAG CAAAACTTAA TTATATCAAA CACAGAAGCA 2280 CCTGGAGACG ATAGAGTGTG CTCTGCCAAT GGATTTATGA CCCAAACTAC CAACAACTCT 2340 AGCCAAGGTT TTTGTGGTAC TATGGGATCA GGAATGAAAA ATGGAGGGCA GGAAACCATT 2400 GAAATGATGA AAGGAGGAAA CCAGACCTTG GAATCCTGCC GGGGGGCTGG GCATCATCAT 2460 ACCCTGGACT CCTGCAGGGG AGGACACACG GAGGTGGACA ACTGCAGATA CACTTACTCG 2520 GAGTGGCACA GTTTTACTCA ACCCCGTCTC GGTGAAAAAT TGCATCGATG TAATCAGAAT 2580 GAAGACCGCA TGCCATCCCA AGATTATGTC CTCACTTATA ACTATGAGGG AAGAGGATCT 2640 CCAGCTGGTT CTGTGGGCTG CTGCAGTGAA AAGCAGGAAG AAGATGGCCT TGACTTTTTA 2700 AATAATTTGG AACCCAAATT TATTACATTA GCAGAAGCAT GCACAAAGAG ATAATGTCAC 2760 AGTGCTACAA TTAGGTCTTT GTCAGACATT CTGGAGGTTT CCAAAAATAA TATTGTAAAG 2820 TTCAATTTCA ACATGTATGT ATATGATGAT TTTTTTCTCA ATTTTGAATT ATGCTACTCA 2880 CCAATTTATA TTTTTAAAGC CAGTTGTTGC TTATCTTTTC CAAAAAGTGA AAAATGTTAA 2940 AACAGACAAC TGGTAAATCT CAAACTCCAG CACTGGAATT AAGGTCTCTA AAGCATCTGC 3000 TCTTTTTTTT TTTTACGGAT ATTTTAGTAA TAAATATGCT GGATAAATAT TAGTCCAACA 3060 ATAGCTAAGT TATGCTAATA TCACATTATT ATGTATTCAC TTTAAGTGAT AGTTTAAAAA 3120 ATAAACAAGA AATATTGAGT ATCACTATGT GAAGAAAGTT TTGGAAAAGA AACAATGAAG 3180 ACTGAATTAA ATTAAAAATG TTGCAGCTCA TAAAGAATTG GGACTCACCC CTACTGCACT 3240 ACCAAATTCA TTTGACTTTG GAGGCAAAAT GTGTTGAAGT GCCCTATGAA GTAGCAATTT 3300 TCTATAGGAA TATAGTTGGA AATAAATGTG TGTGTGTATA TTATTATTAA TCAATGCAAT 3360 ATTTAAAATG AAATGAGAAC AAAGAGGAAA ATGGTAAAAA CTTGAAATGA GGCTGGGGTA 3420 TAGTTTGTCC TACAATAGAA AAAAGAGAGA GCTTCCTAGG CCΓGGGCTCT TAAATGCTGC 3480 ATTATAACTG AGTCTATGAG GAAATAGTTC CTGTCCAATT TGTGTAATTT GTTTAAAATT 3540 GTAAATAAAT TAAACTTTTC TGGTTTCTGT GGGAAGGAAA TAGGGAATCC AATGGAACAG 3600 TAGCTTTGCT TTGCAGTCTG TTTCAAGATT TCTGCATCCA CAAGTTAGTA GCAAACTGGG 3660 GAATACTCGC TGCAGCTGGG GTTCCCTGCT TTTTGGTAGC AAGGGTCCAG AGATGAGGTG 3720 TTTTTTTCGG GGAGCTAATA ACAAAAACAT TTTAAAACTT ACCTTTACTG AAGTTAAATC 3780 CTCTATTGCT GTTTCTATTC TCTCTTATAG TGACCAACAT CTTTTTAATT TAGATCCAAA 3840 TAACCATGTC CTCCTAGAGT TTAGAGGCTA GAGGGAGCTG AGGGGAGGAT CTTACTGAAA 3900 GCACCCTGGG GAGATTGATT GTCCTTAAAC CTAAGCCCCA CAAACTTGAC ACCTGATCAG 3960 GTCTGGGAGC TACAAAATTT CATTTTTCTC CTCACTGCCC TTCTTCTGAG TGGCATTGGC 4020 CTGAATCAAG GAAAGCCAGG CCTTGTGGGC CCCCTTCTTT CGGCTTTCTG CTAAAGCAAC 4080 ACCTCCAGCA GAGATTCCCT TAAGTGACTC CAGGTTTTCC ACCATCCTTC AGCGTGAATT 4140 AATTTTTAAT CAGTTTGCTT TCTCCAGAGA AATTTTAAAA TAATAGAAGA AATAGAAATT 4200 TTGAATGTAT AAAAGAAAAA GATCAAGTTG TCATTTTAGA ACAGAGGGAA CTTTGGGAGA 4260 AAGCAGCCCA AGTAGGTTAT TTGTACAGTC AGAGGGCAAC AGGAAGATGC AGGCCTTCAA 4320 GGGCAAGGAG AGGCCACAAG GAATATGGGT GGGAGTAAAA GCAACATCGT CTGCTTCATA 4380 CTTTTTCCTA GGCTTGGCAC TGCCTTTTCC TTTCTCAGGC CAATGGCAAC TGCCATTTGA 4440 GTCCGGTGAG GGATCAGCCA ACCTCTTCTC TATGGCTCAC CTTATTTGGA GTGAGAAATC 4500 AAGGAGACAG AGCTGACTGC ATGATGAGTC TGAAGGCATT TGCAGGATGA GCCTGAACTG 4560 GTTGTGCAGA ACAAACAAGG CATTCATGGG AATTGTTGTA TTCCTTCTGC AGCCCTCCTT 4620 CTGGGCACTA AGAAGGTCTA TGAATTAAAT GCCTATCTAA AATTCTGATT TATTCCTACA 4680 TTTTCTGTTT TCTAATTTGA CCCTAAAATC TATGTGTTTT AGACTTAGAC TTTTTATTGC 4740 CCCCCCCCCC TTTTTTTTTG AGACGGAGTC TCGCTCTGAC GCACAGGCTG GAGTGCAGTG 4800 GCTCCGATCT CTGCTCACTG AAAGCTCCGC CTCCCGGGTT CATGCCATTC TCCTGCCTCA 4860 GCCTCCTGAG TAGCTGGGAC TACAGGCGCC CACCACCACG CCCGGCTAAT TTTTTGTATT 4920 TTTAATAGAG ACGGGGTTTC ACTGTGTTAG CCAGGATGGT CTCGATCTCC TGACCTCGTG 4980 ATCCGCCTGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG CATGACCCAC CGCTCCCGGC 5040 CTTGTTTTCC GTTTAAAGTC GTCTTCTTTT AATGTAATCA TTTTGAACAT GTGTGAAAGT 5100 TGATCATACG AATTGGATCA ATCTTGAAAT ACTCAACCAA AAGACAGTCG AGAAGCCAGG 5160 GGGAGAAAGA ACTCAGGGCA CAAAATATTG GTCTGAGAAT GGAATTCTCT GTAAGCCTAG 5220 TTGCTGAAAT TTCCTGCTGT AACCAGAAGC CAGTTTTATC TAACGGCTAC TGAAACACCC 5280 ACTGTGTTTT GCTCACTCCC TCACTCACCG ATCAAAACCT GCTACCTCCC CAAGACTTTA 5340 CTAGTGCCGA TAAACTTTCT CAAAGAGCAA CCAGTATCAC TTCCCTGTTT ATAAAACCTC 5400 TAACCATCTC TTTGTTCTTT GAACATGCTG AAAACCACCT GGTCTGCATG TATGCCCGAA 5460 TTTGTAATTC TTTTCTCTCA AATGAAAATT TAATTTTAGG GATTCATTTC TATATTTTCA 5520 CATATGTAGT ATTATTATTT CCTTATATGT GTAAGGTGAA ATTTATGGTA TTTGAGTGTG 5580 CAAGAAAATA TATTTTTAAA GCTTTCATTT TTCCCCCAGT GAATGATTTA GAATTTTTTA 5640 TGTAAATATA CAGAATGTTT TTTCTTACTT TTATAAGGAA GCAGCTGTCT AAAATGCAGT 5700 GGGGTTTGTT TTGCAATGTT TTAAACAGAG TTTTAGTATT GCTATTAAAA GAAGTTACTT 5760 TGCTTTTAAA GAAACTTGGC TGCTTAAAAT AAGCAAAAAT TGGATGCATA AAGTAATATT 5820 TACAGATGTG GGGAGATGTA ATAAAACAAT ATTAACTTGG TTTCTTGTTT TTGCTGTATT 5880 TAGAGATTAA ATAATTCTAA GATGATCACT TTGCAAAATT ATGCTTATGG CTGGCATGGA 5940 AA AGAAATA CTCAATTATG TCTTTGTTGT ATTAATGGGG AATATTTTGG ACAATGTTTC 6000 ATTATCAAAT TGTCGACATC ATTAATATAT ATTGTAATGT TGGGAAGAGA TCACTATTTT 6060 GAAGCACAGC TTTACAGATG AGTATCTATG ATACATATGT ATAATAAATT TTGATCGGGT 6120 ATTAAAAGTA TTAGAAGGTG GTTATAATTG CAGAGTATTC CATGAATAGT ACACTGACAC 6180 AGGGGTTTTA CTTTGAGGAC CAGTGTAGTC AAGGGAAAAC ATGAGTTAAA AAGAAAAGCA 6240 GGCAATATTG CAGTCTTGAT TCTGCCACTT ACAGGATAGA TAATGCCTGA ACTTTAATGA 6300 CAAGATGATC CAACCATAAA GGTGCTCTGT GCTTCACAGT GAATCTTTTC CCCATGCAGG 6360 AGTGTGCTCC CCTACAAACG TTAAGACTGA TCATTTCAAA AATCTATTAG CTATATCAAA 6420 AGCCTTACAT TTTAATATAG GTTGAACCAA AATTTCAATT CCAGTAACTT CTATTGTAAC 6480 CATTATTTTT GTGTATGTCT TCAAGAATGT TCATTGGATT TTTGTTTGTA ATAGTAAAAT 6540 ACCGGATACA TTTCACGTGT CCTTCAGTAT TGATTTGGTT GAATATTGGG TCATAATGGT 6600 TGAGAAGCAT GGACACTAGA GCCAGAATGC TTGGATATGA ATCCTGGATC TGTCACTTAC 6660 TTCTGTGTGA CCTTTGAAAG GCTACTTATT TCCTCTCTTA GCTTTCTCAT TAAAATCAAT 6720 GAACAATGCC AGCCTCATGG GGTTGTTGAA TGATTAAATT AGTTAATATA CCTAAAGTAC 6780 ATAGAACACT GCCTGCACAT AGTAAAAGAA TTATAAGTGT GAGGTAGTTG GTAAAATTAT 6840

GTAGTTGGAT ATACTACCGA ACAATATCTA ATCTCTTTTT AGGGAAATAA AGTTTGTGCA 6900 TATATATAAT CCCGAAACAT G

Seq ID NO: 32 Protein sequence: Protein Accession #: NP_001932.1

1 11 21 31 41 51

1 I I I I 1

MAAAGPRRSV RGAVCLHLLL TLVIFSRDGE ACKKVILNVP SKLEADKIIG RVNLEECFRS 60

ADLIRSΞDPD FRVLNDGSVY TARAVALSDK KRSFTIWLSD KRKQTQKEVT VLLEHQKKVS 120

KTRHTRETVL RRAKRRWAPI PCSMQENSLG PFPLFLQQVE SDAAQNYTVF YSISGRGVDK 180

EPLNLFYIER DTGNLFCTRP VDREEYDVFD LIAYASTADG YSADLPLPLP IRVEDENDNH 240

PVFTEAIYNF EVLESSRPGT TVGWCATDR DEPDTMHTRL KYSILQQTPR SPGLFSVHPS 300

TGVITTVSHY LDREWDKYS LIMKVQDMDG QFFGLIGTST CIITVTDSND NAPTFRQNAY 360

EAFVEENAFN VEILRIPIED KDLINTANWR VNFTILKGNE NGHFKISTDK ETNEGVLSW 420

KPLNYEENRQ VNLEIGVNNE APFARDIPRV TALNRALVTV HVRDLDEGPE CTPAAQYVRI 480

KENLAVGSKI NGYKAYDPEN RNGNGLRYKK LHDPKGWITI DEISGSIITS KILDREVETP 540

KNELYNITVL AIDKDDRSCT GTLAVNIEDV NDNPPEILQE YWICKPKMG YTDILAVDPD 600

EPVHGAPFYF SLPNTSPEIS RL SLTKVND TAARLSYQKN AGFQEYTIPI TVKDRAGQAA 660

TKLLRVNLCE CTHPTQCRAT SRSTGVILGK WAILAILLGI ALLFSVLLTL VCGVFGATKG 720

KRFPEDLAQQ NLIISNTEAP GDDRVCSANG FMTQTTNNSS QGFCGTMGSG MKNGGQETIE 780

MMKGGNQTLE SCRGAGHHHT LDSCRGGHTE VDNCRYTYSE WHSFTQPRLG EKLHRCNQNE 840 DRMPSQDYVL TYNYEGRGSP AGSVGCCSEK QEEDGLDFLN NLEPKFITLA EACTKR

Seq ID NO: 33 DNA sequence

Nucleic Acid Accession #: Eos sequence

Coding sequence: 64-2583

1 11 21 31 41 51

I I I I I I

GGCAGGTCTC GCTCTCGGCA CCCTCCCGGC GCCCGCGTTC TCCTGGCCCT GCCCGGCATC 60

CCGATGGCCG CCGCTGGGCC CCGGCGCTCC GTGCGCGGAG CCGTCTGCCT GCATCTGCTG 120

CTGACCCTCG TGATCTTCAG TCGTGATGGT GAAGCCTGCA AAAAGGTGAT ACTTAATGTA 180

CCTTCTAAAC TAGAGGCAGA CAAAATAATT GGCAGAGTTA ATTTGGAAGA GTGCTTCAGG 240

TCTGCAGACC TCATCCGGTC AAGTGATCCT GATTTCAGAG TTCTAAATGA TGGGTCAGTG 300

TACACAGCCA GGGCTGTTGC GCTGTCTGAT AAGAAAAGAT CATTTACCAT ATGGCTTTCT 360

GACAAAAGGA AACAGACACA GAAAGAGGTT ACTGTGCTGC TAGAACATCA GAAGAAGGTA 420

TCGAAGACAA GACACACTAG AGAAACTGTT CTCAGGCGTG CCAAGAGGAG ATGGGCACCT 480

ATTCCTTGCT CTATGCAAGA GAATTCCTTG GGCCCTTTCC CATTGTTTCT TCAACAAGTT 540

GAATCTGATG CAGCACAGAA CTATACTGTC TTCTACTCAA TAAGTGGACG TGGAGTTGAT 600

AAAGAACCTT TAAATTTGTT TTATATAGAA AGAGACACTG GAAATCTATT TTGCACTCGG 660

CCTGTGGATC GTGAAGAATA TGATGTTTTT GATTTGATTG CTTATGCGTC AACTGCAGAT 720

GGATATTCAG CAGATCTGCC CCTCCCACTA CCCATCAGGG TAGAGGATGA AAATGACAAC 780

CACCCTGTTT TCACAGAAGC AATTTATAAT TTTGAAGTTT TGGAAAGTAG TAGACCTGGT 840

ACTACAGTGG GGGTGGTTTG TGCCACAGAC AGAGATGAAC CGGACACAAT GCATACGCGC 900

CTGAAATACA GCATTTTGCA GCAGACACCA AGGTCACCTG GGCTCTTTTC TGTGCATCCC 960

AGCACAGGCG TAATCACCAC AGTCTCTCAT TATTTGGACA GAGAGGTTGT AGACAAGTAC 1020

TCATTGATAA TGAAAGTACA AGACATGGAT GGCCAGTTTT TTGGATTGAT AGGCACATCA 1080

ACTTGTATCA TAACAGTAAC AGATTCAAAT GATAATGCAC CCACTTTCAG ACAAAATGCT 1140

TATGAAGCAT TTGTAGAGGA AAATGCATTC AATGTGGAAA TCTTACGAAT ACCTATAGAA 1200

GATAAGGATT TAATTAACAC TGCCAATTGG AGAGTCAATT TTACCATTTT AAAGGGAAAT 1260

GAAAATGGAC ATTTCAAAAT CAGCACAGAC AAAGAAACTA ATGAAGGTGT TCTTTCTGTT 1320

GTAAAGCCAC TGAATTATGA AGAAAACCGT CAAGTGAACC TGGAAATTGG AGTAAACAAT 1380

GAAGCGCCAT TTGCTAGAGA TATTCCCAGA GTGACAGCCT TGAACAGAGC CTTGGTTACA 1440

GTTCATGTGA GGGATCTGGA TGAGGGGCCT GAATGCACTC CTGCAGCCCA ATATGTGCGG 1500

ATTAAAGAAA ACTTAGCAGT GGGGTCAAAG ATCAACGGCT ATAAGGCATA TGACCCCGAA 1560

AATAGAAATG GCAATGGTTT AAGGTACAAA AAATTGCATG ATCCTAAAGG TTGGATCACC 1620

ATTGATGAAA TTTCAGGGTC AATCATAACT TCCAAAATCC TGGATAGGGA GGTTGAAACT 1680

CCCAAAAATG AGTTGTATAA TATTACAGTC CTGGCAATAG ACAAAGATGA TAGATCATGT 1740

ACTGGAACAC TTGCTGTGAA CATTGAAGAT GTAAATGATA ATCCACCAGA AATACTTCAA 1800

GAATATGTAG TCATTTGCAA ACCAAAAATG GGGTATACCG ACATTTTAGC TGTTGATCCT 1860

GATGAACCTG TCCATGGAGC TCCATTTTAT TTCAGTTTGC CCAATACTTC TCCAGAAATC 1920

AGTAGACTGT GGAGCCTCAC CAAAGTTAAT GATACAGCTG CCCGTCTTTC ATATCAGAAA 1980

AATGCTGGAT TTCAAGAATA TACCATTCCT ATTACTGTAA AAGACAGGGC CGGCCAAGCT 2040

GCAACAAAAT TATTGAGAGT TAATCTGTGT GAATGTACTC ATCCAACTCA GTGTCGTGCG 2100

ACTTCAAGGA GTACAGGAGT AATACTTGGA AAATGGGCAA TCCTTGCAAT ATTACTGGGT 2160

ATAGCACTGC TCTTTTCTGT ATTGCTAACT TTAGTATGTG GAGTTTTTGG TGCAACTAAA 2220

GGGAAACGTT TTCCTGAAGA TTTAGCACAG CAAAACTTAA TTATATCAAA CACAGAAGCA 2280

CCTGGAGACG ATAGAGTGTG CTCTGCCAAT GGATTTATGA CCCAAACTAC CAACAACTCT 2340

AGCCAAGGTT TTTGTGGTAC TATGGGATCA GGAATGAAAA ATGGAGGGCA GGAAACCATT 2400

GAAATGATGA AAGGAGGAAA CCAGACCTTG GAATCCTGCC GGGGGGCTGG GCATCATCAT 2460

ACCCTGGACT CCTGCAGGGG AGGACACACG GAGGTGGACA ACTGCAGATA CACTTACTCG 2520

GAGTGGCACA GTTTTACTCA ACCCCGTCTC GGTGAAGAAT CCATTAGAGG ACACACTGGT 2580

TAAAAATTAA ACATAAAAGA AATTGCATCG ATGTAATCAG AATGAAGACC GCATGCCATC 2640

CCAAGATTAT GTCCTCACTT ATAACTATGA GGGAAGAGGA TCTCCAGCTG GTTCTGTGGG 2700

CTGCTGCAGT GAAAAGCAGG AAGAAGATGG CCTTGACTTT TTAAATAATT TGGAACCCAA 2760

ATTTATTACA TTAGCAGAAG CATGCACAAA GAGATAATGT CACAGTGCTA CAATTAGGTC 2820

TTTGTCAGAC ATTCTGGAGG TTTCCAAAAA TAATATTGTA AAGTTCAATT TCAACATGTA 2880

TGTATATGAT GATTTTTTTC TCAATTTTGA ATTATGCTAC TCACCAATTT ATATTTTTAA 2940

AGCCAGTTGT TGCTTATCTT TTCCAAAAAG TGAAAAATGT TAAAACAGAC AACTGGTAAA 3000

TCTCAAACTC CAGCACTGGA ATTAAGGTCT CTAAAGCATC TGCTCTTTTT TTTTTTTACG 3060

GATATTTTAG TAATAAATAT GCTGGATAAA TATTAGTCCA ACAATAGCTA AGTTATGCTA 3120

ATATCACATT ATTATGTATT CACTTTAAGT GATAGTTTAA AAAATAAACA AGAAATATTG 3180

AGTATCACTA TGTGAAGAAA GTTTTGGAAA AGAAACAATG AAGACTGAAT TAAATTAAAA 3240

ATGTTGCAGC TCATAAAGAA TTGGGACTCA CCCCTACTGC ACTACCAAAT TCATTTGACT 3300 TTGGAGGCAA AATGTGTTGA AGTGCCCTAT GAAGTAGCAA TTTTCTATAG GAATATAGTT 3360

GGAAATAAAT GTGTGTGTGT ATATTATTAT TAATCAATGC AATATTTAAA ATGAAATGAG 3420

AACAAAGAGG AAAATGGTAA AAACTTGAAA TGAGGCTGGG GTATAGTTTG TCCTACAATA 3480

GAAAAAAGAG AGAGCTTCCT AGGCCTGGGC TCTTAAATGC TGCATTATAA CTGAGTCTAT 3540

GAGGAAATAG TTCCTGTCCA ATTTGTGTAA TTTGTTTAAA ATTGTAAATA AATTAAACTT 3600

TTCTGGTTTC TGTGGGAAGG AAATAGGGAA TCCAATGGAA CAGTAGCTTT GCTTTGCAGT 3660

CTGTTTCAAG ATTTCTGCAT CCACAAGTTA GTAGCAAACT GGGGAATACT CGCTGCAGCT 3720

GGGGTTCCCT GCTTTTTGGT AGCAAGGGTC CAGAGATGAG GTGTTTTTTT CGGGGAGCTA 3780

ATAACAAAAA CATTTTAAAA CTTACCTTTA CTGAAGTTAA ATCCTCTATT GCTGTTTCTA 3840

TTCTCTCTTA TAGTGACCAA CATCTTTTTA ATTTAGATCC AAATAACCAT GTCCTCCTAG 3900

AGTTTAGAGG CTAGAGGGAG CTGAGGGGAG GATCTTACTG AAAGCACCCT GGGGAGATTG 3960

ATTGTCCTTA AACCTAAGCC CCACAAACTT GACACCTGAT CAGGTCTGGG AGCTACAAAA 4020

TTTCATTTTT CTCCTCACTG CCCTTCTTCT GAGTGGCATT GGCCTGAATC AAGGAAAGCC 4080

AGGCCTTGTG GGCCCCCTTC TTTCGGCTTT CTGCTAAAGC AACACCTCCA GCAGAGATTC 4140

CCTTAAGTGA CTCCAGGTTT TCCACCATCC TTCAGCGTGA ATTAATTTTT AATCAGTTTG 4200

CTTTCTCCAG AGAAATTTTA AAATAATAGA AGAAATAGAA ATTTTGAATG TATAAAAGAA 4260

AAAGATCAAG TTGTCATTTT AGAACAGAGG GAACTTTGGG AGAAAGCAGC CCAAGTAGGT 4320

TATTTGTACA GTCAGAGGGC AACAGGAAGA TGCAGGCCTT CAAGGGCAAG GAGAGGCCAC 4380

AAGGAATATG GGTGGGAGTA AAAGCAACAT CGTCTGCTTC ATACTTTTTC CTAGGCTTGG 4440

CACTGCCTTT TCCTTTCTCA GGCCAATGGC AACTGCCATT TGAGTCCGGT GAGGGATCAG 4500

CCAACCTCTT CTCTATGGCT CACCTTATTT GGAGTGAGAA ATCAAGGAGA CAGAGCTGAC 4560

TGCATGATGA GTCTGAAGGC ATTTGCAGGA TGAGCCTGAA CTGGTTGTGC AGAACAAACA 4620

AGGCATTCAT GGGAATTGTT GTATTCCTTC TGCAGCCCTC CTTCTGGGCA CTAAGAAGGT 4680

CTATGAATTA AATGCCTATC TAAAATTCTG ATTTATTCCT ACATTTTCTG TTTTCTAATT 4740

TGACCCTAAA ATCTATGTGT TTTAGACTTA GACTTTTTAT TGCCCCCCCC CCCTTTTTTT 4800

TTGAGACGGA GTCTCGCTCT GACGCACAGG CTGGAGTGCA GTGGCTCCGA TCTCTGCTCA 4860

CTGAAAGCTC CGCCTCCCGG GTTCATGCCA TTCTCCTGCC TCAGCCTCCT GAGTAGCTGG 4920

GACTACAGGC GCCCACCACC ACGCCCGGCT AATTTTTTGT ATTTTTAATA GAGACGGGGT 4980

TTCACTGTGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC GTGATCCGCC TGCCTCGGCC 5040

TCCCAAAGTG CTGGGATTAC AGGCATGACC CACCGCTCCC GGCCTTGTTT TCCGTTTAAA 5100

GTCGTCTTCT TTTAATGTAA TCATTTTGAA CATGTGTGAA AGTTGATCAT ACGAATTGGA 5160

TCAATCTTGA AATACTCAAC CAAAAGACAG TCGAGAAGCC AGGGGGAGAA AGAACTCAGG 5220

GCACAAAATA TTGGTCTGAG AATGGAATTC TCTGTAAGCC TAGTTGCTGA AATTTCCTGC 5280

TGTAACCAGA AGCCAGTTTT ATCTAACGGC TACTGAAACA CCCACTGTGT TTTGCTCACT 5340

CCCACTCACC GATCAAAACC TGCTACCTCC CCAAGACTTT ACTAGTGCCG ATAAACTTTC 5400

TCAAAGAGCA ACCAGTATCA CTTCCCTGTT TATAAAACCT CTAACCATCT CTTTGTTCTT 5460

TGAACATGCT GAAAACCACC TGGTCTGCAT GTATGCCCGA ATTTGTAATT CTTTTCTCTC 5520

AAATGAAAAT TTAATTTTAG GGATTCATTT CTATATTTTC ACATATGTAG TATTATTATT 5580

TCCTTATATG TGTAAGGTGA AATTTATGGT ATTTGAGTGT GCAAGAAAAT ATATTTTTAA 5640

AGCTTTCATT TTTCCCCCAG TGAATGATTT AGAATTTTTT ATGTAAATAT ACAGAATGTT 5700

TTTTCTTACT TTTATAAGGA AGCAGCTGTC TAAAATGCAG TGGGGTTTGT TTTGCAATGT 5760

TTTAAACAGA GTTTTAGTAT TGCTATTAAA AGAAGTTACT TTGCTTTTAA AGAAACTTGG 5820

CTGCTTAAAA TAAGCAAAAA TTGGATGCAT AAAGTAATAT TTACAGATGT GGGGAGATGT 5880

AATAAAACAA TATTAACTTG GCTGCTTAAA ATAAGCAAAA ATTGGATGCA TAAAGTAATA 5940

TTTACAGATG TGGGGAGATG TAATAAAACA ATATTAACTT GGTTTCTTGT TTTTGCTGTA 6000

TTTAGAGATT AAATAATTCT AAGATGATCA CTTTGCAAAA TTATGCTTAT GGCTGGCATG 6060

GAAATAGAAA TACTCAATTA TGTCTTTGTT GTATTAATGG GGAATATTTT GGACAATGTT 6120

TCATTATCAA ATTGTCGACA TCATTAATAT ATATTGTAAT GTTGGGAAGA GATCACTATT 6180

TTGAAGCACA GCTTTACAGA TGAGTATCTA TGATACATAT GTATAATAAA TTTTGATCGG 6240

GTATTAAAAG TATTAGAAGG TGGTTATAAT TGCAGAGTAT TCCATGAATA GTACACTGAC 6300

ACAGGGGTTT TACTTTGAGG ACCAGTGTAG TCAAGGGAAA ACATGAGTTA AAAAGAAAAG 6360

CAGGCAATAT TGCAGTCTTG ATTCTGCCAC TTACAGGATA GATAATGCCT GAACTTTAAT 6420

GACAAGATGA TCCAACCATA AAGGTGCTCT GTGCTTCACA GTGAATCTTT TCCCCATGCA 6480

GGAGTGTGCT CCCCTACAAA CGTTAAGACT GATCATTTCA AAAATCTATT AGCTATATCA 6540

AAAGCCTTAC ATTTTAATAT AGGTTGAACC AAAATTTCAA TTCCAGTAAC TTCTATTGTA 6600

ACCATTATTT TTGTGTATGT CTTCAAGAAT GTTCATTGGA TTTTTGTTTG TAATAGTAAA 6660

ATACCGGATA CATTTCACGT GTCCTTCAGT ATTGATTTGG TTGAATATTG GGTCATAATG 6720

GTTGAGAAGC ATGGACACTA GAGCCAGAAT GCTTGGATAT GAATCCTGGA TCTGTCACTT 6780

ACTTCTGTGT GACCTTTGAA AGGCTACTTA TTTCCTCTCT TAGCTTTCTC ATTAAAATCA 6840

ATGAACAATG CCAGCCTCAT GGGGTTGTTG AATGATTAAA TTAGTTAATA TACCTAAAGT 6900

ACATAGAACA CTGCCTGCAC ATAGTAAAAG AATTATAAGT GTGAGGTAGT TGGTAAAATT 6960

ATGTAGTTGG ATATACTACC GAACAATATC TAATCTCTTT TTAGGGAAAT AAAGTTTGTG 7020 CATATATATA ATCCCGAAAC ATG

Seq ID NO: 34 Protein sequence: Protein Accession #: NP_077741.1

1 11 21 31 41 51

I I I I I 1

MAAAGPRRSV RGAVCLHLLL TLVIFSRDGE ACKKVILNVP SKLEADKIIG RVNLEECFRS 60

ADLIRSSDPD FRVLNDGSVY TARAVALSDK KRSFTIWLSD KRKQTQKEVT VLLEHQKKVS 120

KTRHTRETVL RRAKRRWAPI PCSMQENSLG PFPLFLQQVE SDAAQNYTVF YSISGRGVDK 180

EPLNLFYIER DTGNLFCTRP VDREEYDVFD LIAYASTADG YSADLPLPLP IRVEDENDNH 240

PVFTEAIYNF EVLESSRPGT TVGWCATDR DEPDTMHTRL KYSILQQTPR SPGLFSVHPS 300

TGVITTVSHY LDREWDKYS LIMKVQDMDG QFFGLIGTST CIITVTDSND NAPTFRQNAY 360

EAFVEENAFN VEILRIPIED KDLINTAN R VNFTILKGNE NGHFKISTDK ETNEGVLSW 420

KPLNYEENRQ VNLEIGVNNE APFARDIPRV TALNRALVTV HVRDLDEGPE CTPAAQYVRI 480

KENLAVGSKI NGYKAYDPEN RNGNGLRYKK LHDPKGWITI DEISGSIITS KILDREVETP 540

KNELYNITVL AIDKDDRSCT GTLAVNIEDV NDNPPEILQE YWICKPKMG YTDILAVDPD 600

EPVHGAPFYF SLPNTSPEIS RLWSLTKVND TAARLSYQKN AGFQEYTIPI TVKDRAGQAA 660

TKLLRVNLCE CTHPTQCRAT SRSTGVILGK WAILAILLGI ALLFSVLLTL VCGVFGATKG 720

KRFPEDLAQQ NLIISNTEAP GDDRVCSANG FMTQTTNNSS QGFCGTMGSG MKNGGQETIE 780 MMKGGNQTLE SCRGAGHHHT LDSCRGGHTE VDNCRYTYSE WHSFTQPRLG EESIRGHTG

Seq ID NO: 35 DNA sequence

Nucleic Acid Accession #: Eos sequence

Coding sequence: 146-1273- 1 11 21 31 41 51

I I I I I I

GGGAGTGGGC GTGGCGGTGC TGCCCAGGTG AGCCACCGCT GCTTCTGCCC AGACACGGTC 60

GCCTCCACAT CCAGGTCTTT GTGCTCCTCG CTTGCCTGTT CCTTTTCCAC GCATTTTCCA 120

GGATAACTGT GACTCCAGGC CCGCAATGGA TGCCCTGCAA CTAGCAAATT CGGCTTTTGC 180

CGTTGATCTG TTCAAACAAC TATGTGAAAA GGAGCCACTG GGCAATGTCC TCTTCTCTCC 240

AATCTGTCTC TCCACCTCTC TGTCACTTGC TCAAGTGGGT GCTAAAGGTG ACACTGCAAA 300

TGAAATTGGA CAGGTTCTTC ATTTTGAAAA TGTCAAAGAT ATACCCTTTG GATTTCAAAC 360

AGTAACATCG GATGTAAACA AACTTAGTTC CTTTTACTCA CTGAAACTAA TCAAGCGGCT 420

CTACGTAGAC AAATCTCTGA ATCTTTCTAC AGAGTTCATC AGCTCTACGA AGAGACCCTA 480

TGCAAAGGAA TTGGAAACTG TTGACTTCAA AGATAAATTG GAAGAAACGA AAGGTCAGAT 540

CAACAACTCA ATTAAGGATC TCACAGATGG CCACTTTGAG AACATTTTAG CTGACAACAβ 600

TGTGAACGAC CAGACCAAAA TCCTTGTGGT TAATGCTGCC TACTTTGTTG GCAAGTGGAT 660

GAAGAAATTT CCTGAATCAG AAACAAAAGA ATGTCCTTTC AGACTCAACA AGACAGACAC 720

CAAACCAGTG CAGATGATGA ACATGGAGGC CACGTTCTGT ATGGGAAACA TTGACAGTAT 780

CAATTGTAAG ATCATAGAGC TTCCTTTTCA AAATAAGCAT CTCAGCATGT TCATCCTACT 840

ACCCAAGGAT GTGGAGGATG AGTCCACAGG CTTGGAGAAG ATTGAAAAAC AACTCAACTC 900

AGAGTCACTG TCACAGTGGA CTAATCCCAG CACCATGGCC AATGCCAAGG TCAAACTCTC 960

CATTCCAAAA TTTAAGGTGG AAAAGATGAT TGATCCCAAG GCTTGTCTGG AAAATCTAGG 1020

GCTGAAACAT ATCTTCAGTG AAGACACATC TGATTTCTCT GGAATGTCAG AGACCAAGGG 1080

AGTGGCCCTA TCAAATGTTA TCCACAAAGT GTGCTTAGAA ATAACTGAAG ATGGTGGGGA 1140

TTCCATAGAG GTGCCAGGAG CACGGATCCT GCAGCACAAG GATGAATTGA ATGCTGACCA 1200

TCCCTTTATT TACATCATCA GGCACAACAA AACTCGAAAC ATCATTTTCT TTGGCAAATT 1260

CTGTTCTCCT TAAGTGGCAT AGCCCATGTT AAGTCCTCCC TGACTTTTCT GTGGATGCCG 1320

ATTTCTGTAA ACTCTGCATC CAGAGATTCA TTTTCTAGAT ACAATAAATT GCTAATGTTG 1380

CTGGATCAGG AAGCCGCCAG TACTTGTCAT ATGTAGCCTT CACACAGATA GACCTTTTTT 1440

TTTTTCCAAT TCTATCTTTT GTTTCCTTTT TTCCCATAAG ACAATGACAT ACGCTTTTAA 1500

TGAAAAGGAA TCACGTTAGA GGAAAAATAT TTATTCATTA TTTGTCAAAT TGTCCGGGGT 1560

AGTTGGCAGA AATACAGTCT TCCACAAAGA AAATTCCTAT AAGGAAGATT TGGAAGCTCT 1620

TCTTCCCAGC ACTATGCTTT CCTTCTTTGG GATAGAGAAT GTTCCAGACA TTCTCGCTTC 1680

CCTGAAAGAC TGAAGAAAGT GTAGTGCATG GGACCCACGA AACTGCCCTG GCTCCAGTGA 1740

AACTTGGGCA CATGCTCAGG CTACTATAGG TCCAGAAGTC CTTATGTTAA GCCCTGGCAG 1800

GCAGGTGTTT ATTAAAATTC TGAATTTTGG GGATTTTCAA AAGATAATAT TTTACATACA 1860

CTGTATGTTA TAGAACTTCA TGGATCAGAT CTGGGGCAGC AACCTATAAA TCAACACCTT 1920

AATATGCTGC AACAAAATGT AGAATATTCA GACAAAATGG ATACATAAAG ACTAAGTAGC 1980

CCATAAGGGG TCAAAATTTG CTGCCAAATG CGTATGCCAC CAACTTACAA AAACACTTCG 2040

TTCGCAGAGC TTTTCAGATT GTGGAATGTT GGATAAGGAA TTATAGACCT CTAGTAGCTG 2100

AAATGCAAGA CCCCAAGAGG AAGTTCAGAT CTTAATATAA ATTCACTTTC ATTTTTGATA 2160

GCTGTCCCAT CTGGTCATGT GGTTGGCACT AGACTGGTGG CAGGGGCTTC TAGCTGACTC 2220

GCACAGGGAT TCTCACAATA GCCGATATCA GAATTTGTGT TGAAGGAACT TGTCTCTTCA 2280

TCTAATATGA TAGCGGGAAA AGGAGAGGAA ACTACTGCCT TTAGAAAATA TAAGTAAAGT 2340

GATTAAAGTG CTCACGTTAC CTTGACACAT AGTTTTTCAG TCTATGGGTT TAGTTACTTT 2400

AGATGGCAAG CATGTAACTT ATATTAATAG TAATTTGTAA AGTTGGGTGG ATAAGCTATC 2460

CCTGTTGCCG GTTCATGGAT TACTTCTCTA TAAAAAATAT ATATTTACCA AAAAATTTTG 2520

TGACATTCCT TCTCCCATCT CTTCCTTGAC ATGCATTGTA AATAGGTTCT TCTTGTTCTG 2580 AGATTCAATA TTGAATTTCT CCTATGCTAT TGACAATAAA ATATTATTGA ACTACC

Seq ID NO: 36 Protein sequence: Protein Accession ft: NP_002630.1

1 11 21 31 41 51

I I I I I I

MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF 60

ENVKDIPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD 120

FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKIL WNAAYFVGK WMKKFPESET 180

KECPFRLNKT DTKPVQMMNM EATFCMGNID SINCKIIELP FQNKHLSMFI LLPKDVEDES 240

TGLEKIEKQL NSESLSQWTN PSTMANAKVK LSIPKFKVEK MIDPKACLEN LGLKHIFSED 300

TSDFSGMSET KGVALSNVIH KVCLEITEDG GDSIEVPGAR ILQHKDELNA DHPFIYIIRH 360 NKTRNIIFFG KFCSP

Seq ID NO: 37 DNA sequence

Nucleic Acid Accession #: NM_0168583

Coding sequence: 72-842

1 11 21 31 41 51

I I I I I I

GGAGTGGGGG AGAGAGAGGA GACCAGGACA GCTGCTGAGA CCTCTAAGAA GTCCAGATAC 60

TAAGAGCAAA GATGTTTCAA ACTGGGGGCC TCATTGTCTT CTACGGGCTG TTAGCCCAGA 120

CCATGGCCCA GTTTGGAGGC CTGCCCGTGC CCCTGGACCA GACCCTGCCC TTGAATGTGA 180

ATCCAGCCCT GCCCTTGAGT CCCACAGGTC TTGCAGGAAG CTTGACAAAT GCCCTCAGCA 240

ATGGCCTGCT GTCTGGGGGC CTGTTGGGCA TTCTGGAAAA CCTTCCGCTC CTGGACATCC 300

TGAAGCCTGG AGGAGGTACT TCTGGTGGCC TCCTTGGGGG ACTGCTTGGA AAAGTGACGT 360

CAGTGATTCC TGGCCTGAAC AACATCATTG ACATAAAGGT CACTGACCCC CAGCTGCTGG 420

AACTTGGCCT TGTGCAGAGC CCTGATGGCC ACCGTCTCTA TGTCACCATC CCTCTCGGCA 480

TAAAGCTCCA AGTGAATACG CCCCTGGTCG GTGCAAGTCT GTTGAGGCTG GCTGTGAAGC 540

TGGACATCAC TGCAGAAATC TTAGCTGTGA GAGATAAGCA GGAGAGGATC CACCTGGTCC 600

TTGGTGACTG CACCCATTCC CCTGGAAGCC TGCAAATTTC TCTGCTTGAT GGACTTGGCC 660

CCCTCCCCAT TCAAGGTCTT CTGGACAGCC TCACAGGGAT CTTGAATAAA GTCCTGCCTG 720

AGTTGGTTCA GGGCAACGTG TGCCCTCTGG TCAATGAGGT TCTCAGAGGC TTGGACATCA 780

CCCTGGTGCA TGACATTGTT AACATGCTGA TCCACGGACT ACAGTTTGTC ATCAAGGTCT 840

AAGCCTTCCA GGAAGGGGCT GGCCTCTGCT GAGCTGCTTC CCAGTGCTCA CAGATGGCTG 900

GCCCATGTGC TGGAAGATGA CACAGTTGCC TTCTCTCCGA GGAACCTGCC CCCTCTCCTT 960

TCCCACCAGG CGTGTGTAAC ATCCCATGTG CCTCACCTAA TAAAATGGCT CTTCTTCTGC 1020 AAAAAAAAAA AAAAAAAAAA AAAAAAAAA Seq ID NO: 38 Protein sequence: Protein Accession #: NP_057667

1 11 21 31 41 51

I I I I I I

MFQTGGLIVF YGLLAQTMAQ FGGLPVPLDQ TLPLNVNPAL PLSPTGLAGS LTNALSNGLL 60

SGGLLGILEN LPLLDILKPG GGTSGGLLGG LLGKVTSVIP GLNNIIDIKV TDPQLLELGL 120

VQSPDGHRLY VTIPLGIKLQ VNTPLVGASL LRLAVKLDIT AEILAVRDKQ ERIHLVLGDC 180

THSPGSLQIS LLDGLGPLPI QGLLDSLTGI LNKVLPELVQ GNVCPLVNEV LRGLDITLVH 240 DIVNMLIHGL QFVIKV

Seq ID NO: 39 DNA sequence Nucleic Acid Accession #: NM_004363.1 Coding sequence: 115-2223

1 11 21 31 41 51

I I I I I I

CTCAGGGCAG AGGGAGGAAG GACAGCAGAC CAGACAGTCA CAGCAGCCTT GACAAAACGT 60

TCCTGGAACT CAAGCTCTTC TCCACAGAGG AGGACAGAGC AGACAGCAGA GACCATGGAG 120

TCTCCCTCGG CCCCTCCCCA CAGATGGTGC ATCCCCTGGC AGAGGCTCCT GCTCACAGCC 180

TCACTTCTAA CCTTCTGGAA CCCGCCCACC ACTGCCAAGC TCACTATTGA ATCCACGCCG 240

TTCAATGTCG CAGAGGGGAA GGAGGTGCTT CTACTTGTCC ACAATCTGCC CCAGCATCTT 300

TTTGGCTACA GCTGGTACAA AGGTGAAAGA GTGGATGGCA ACCGTCAAAT TATAGGATAT 360

GTAATAGGAA CTCAACAAGC TACCCCAGGG CCCGCATACA GTGGTCGAGA GATAATATAC 420

CCCAATGCAT CCCTGCTGAT CCAGAACATC ATCCAGAATG ACACAGGATT CTACACCCTA 480

CACGTCATAA AGTCAGATCT TGTGAATGAA GAAGCAACTG GCCAGTTCCG GGTATACCCG 540

GAGCTGCCCA AGCCCTCCAT CTCCAGCAAC AACTCCAAAC CCGTGGAGGA CAAGGATGCT 600

GTGGCCTTCA CCTGTGAACC TGAGACTCAG GACGCAACCT ACCTGTGGTG GGTAAACAAT 660

CAGAGCCTCC CGGTCAGTCC CAGGCTGCAG CTGTCCAATG GCAACAGGAC CCTCACTCTA 720

TTCAATGTCA CAAGAAATGA CACAGCAAGC TACAAATGTG AAACCCAGAA CCCAGTGAGT 780

GCCAGGCGCA GTGATTCAGT CATCCTGAAT GTCCTCTATG GCCCGGATGC CCCCACCATT 840

TCCCCTCTAA ACACATCTTA CAGATCAGGG GAAAATCTGA ACCTCTCCTG CCACGCAGCC 900

TCTAACCCAC CTGCACAGTA CTCTTGGTTT GTCAATGGGA CTTTCCAGCA ATCCACCCAA 960

GAGCTCTTTA TCCCCAACAT CACTGTGAAT AATAGTGGAT CCTATACGTG CCAAGCCCAT 1020

AACTCAGACA CTGGCCTCAA TAGGACCACA GTCACGACGA TCACAGTCTA TGCAGAGCCA 1080

CCCAAACCCT TCATCACCAG CAACAACTCC AACCCCGTGG AGGATGAGGA TGCTGTAGCC 1140

TTAACCTGTG AACCTGAGAT TCAGAACACA ACCTACCTGT GGTGGGTAAA TAATCAGAGC 1200

CTCCCGGTCA GTCCCAGGCT GCAGCTGTCC AATGACAACA GGACCCTCAC TCTACTCAGT 1260

GTCACAAGGA ATGATGTAGG ACCCTATGAG TGTGGAATCC AGAACGAATT AAGTGTTGAC 1320

CACAGCGACC CAGTCATCCT GAATGTCCTC TATGGCCCAG ACGACCCCAC CATTTCCCCC 1380

TCATACACCT ATTACCGTCC AGGGGTGAAC CTCAGCCTCT CCTGCCATGC AGCCTCTAAC 1440

CCACCTGCAC AGTATTCTTG GCTGATTGAT GGGAACATCC AGCAACACAC ACAAGAGCTC 1500

TTTATCTCCA ACATCACTGA GAAGAACAGC GGACTCTATA CCTGCCAGGC CAATAACTCA 1560

GCCAGTGGCC ACAGCAGGAC TACAGTCAAG ACAATCACAG TCTCTGCGGA GCTGCCCAAG 1620

CCCTCCATCT CCAGCAACAA CTCCAAACCC GTGGAGGACA AGGATGCTGT GGCCTTCACC 1680

TGTGAACCTG AGGCTCAGAA CACAACCTAC CTGTGGTGGG TAAATGGTCA GAGCCTCCCA 1740

GTCAGTCCCA GGCTGCAGCT GTCCAATGGC AACAGGACCC TCACTCTATT CAATGTCACA 1800

AGAAATGACG CAAGAGCCTA TGTATGTGGA ATCCAGAACT CAGTGAGTGC AAACCGCAGT 1860

GACCCAGTCA CCCTGGATGT CCTCTATGGG CCGGACACCC CCATCATTTC CCCCCCAGAC 1920

TCGTCTTACC TTTCGGGAGC GAACCTCAAC CTCTCCTGCC ACTCGGCCTC TAACCCATCC 1980

CCGCAGTATT CTTGGCGTAT CAATGGGATA CCGCAGCAAC ACACACAAGT TCTCTTTATC 2040

GCCAAAATCA CGCCAAATAA TAACGGGACC TATGCCTGTT TTGTCTCTAA CTTGGCTACT 2100

GGCCGCAATA ATTCCATAGT CAAGAGCATC ACAGTCTCTG CATCTGGAAC TTCTCCTGGT 2160

CTCTCAGCTG GGGCCACTGT CGGCATCATG ATTGGAGTGC TGGTTGGGGT TGCTCTGATA 2220

TAGCAGCCCT GGTGTAGTTT CTTCATTTCA GGAAGACTGA CAGTTGTTTT GCTTCTTCCT 2280

TAAAGCATTT GCAACAGCTA CAGTCTAAAA TTGCTTCTTT ACCAAGGATA TTTACAGAAA 2340

AGACTCTGAC CAGAGATCGA GACCATCCTA GCCAACATCG TGAAACCCCA TCTCTACTAA 2400

AAATACAAAA ATGAGCTGGG CTTGGTGGCG CGCACCTGTA GTCCCAGTTA CTCGGGAGGC 2460

TGAGGCAGGA GAATCGCTTG AACCCGGGAG GTGGAGATTG CAGTGAGCCC AGATCGCACC 2520

ACTGCACTCC AGTCTGGCAA CAGAGCAAGA CTCCATCTCA AAAAGAAAAG AAAAGAAGAC 2580

TCTGACCTGT ACTCTTGAAT ACAAGTTTCT GATACCACTG CACTGTCTGA GAATTTCCAA 2640

AACTTTAATG AACTAACTGA CAGCTTCATG AAACTGTCCA CCAAGATCAA GCAGAGAAAA 2700

TAATTAATTT CATGGGACTA AATGAACTAA TGAGGATTGC TGATTCTTTA AATGTCTTGT 2760

TTCCCAGATT TCAGGAAACT TTTTTTCTTT TAAGCTATCC ACTCTTACAG CAATTTGATA 2820

AAATATACTT TTGTGAACAA AAATTGAGAC ATTTACATTT TCTCCCTATG TGGTCGCTCC 2880

AGACTTGGGA AACTATTCAT GAATATTTAT ATTGTATGGT AATATAGTTA TTGCACAAGT 2940 TCAATAAAAA TCTGCTCTTT GTATAACAGA AAAA

Seq ID NO: 40 Protein sequence: Protein Accession #: NP_004354.1

1 11 21 31 41 51

I I I I I I

MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE VLLLVHNLPQ 60

HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI IYPNASLLIQ NIIQNDTGFY 120

TLHVIKSDLV NEEATGQFRV YPELPKPSIS SNNSKPVEDK DAVAFTCEPE TQDATYLWWV 180

NNQSLPVSPR LQLSNGNRTL TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP 240

TISPLNTSYR SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ 300

AHNSDTGLNR TTVTTITVYA EPPKPFITSN NSNPVEDEDA VALTCEPEIQ NTTYLWWVNN 360

QSLPVSPRLQ LSNDNRTLTL LSVTRNDVGP YECGIQNELS VDHSDPVILN VLYGPDDPTI 420

SPSYTYYRPG VNLSLSCHAA SNPPAQYSWL IDGNIQQHTQ ELFISNITEK NSGLYTCQAN 480

NSASGHSRTT VKTITVSAEL PKPSISSNNS KPVEDKDAVA FTCEPEAQNT TYLWWVNGQS 540

LPVSPRLQLS NGNRTLTLFN VTRNDARAYV CGIQNSVSAN RSDPVTLDVL YGPDTPIISP 600

PDSSYLSGAN LNLSCHSASN PSPQYSWRIN GIPQQHTQVL FIAKITPNNN GTYACFVSNL 660 ATGRNNSIVK SITVSASGTS PGLSAGATVG IMIGVLVGVA LI Seq ID NO: 41 DNA sequence

Nucleic Acid Accession #: NM_006952.1

Coding sequence: 11-793

1 11 21 31 , 41 51

1 I I I I 1

AATCCCGACA ATGGCGAAAG ACAACTCAAC TGTTCGTTGC TTCCAGGGCC TGCTGATTTT 60

TGGAAATGTG ATTATTGGTT GTTGCGGCAT TGCCCTGACT GCGGAGTGCA TCTTCTTTGT 120

ATCTGACCAA CACAGCCTCT ACCCACTGCT TGAAGCCACC GACAACGATG ACATCTATGG 180

GGCTGCCTGG ATCGGCATAT TTGTGGGCAT CTGCCTCTTC TGCCTGTCTG TTCTAGGCAT 240

TGTAGGCATC ATGAAGTCCA GCAGGAAAAT TCTTCTGGCG TATTTCATTC TGATGTTTAT 300

AGTATATGCC TTTGAAGTGG CATCTTGTAT CACAGCAGCA ACACAACGAG ACTTTTTCAC 360

ACCCAACCTC TTCCTGAAGC AGATGCTAGA GAGGTACCAA AACAACAGCC CTCCAAACAA 420

TGATGACCAG TGGAAAAACA ATGGAGTCAC CAAAACCTGG GACAGGCTCA TGCTCCAGGA 480

CAATTGCTGT GGCGTAAATG GTCCATCAGA CTGGCAAAAA TACACATCTG CCTTCCGGAC 540

TGAGAATAAT GATGCTGACT ATCCCTGGCC TCGTCAATGC TGTGTTATGA ACAATCTTAA 600

AGAACCTCTC AACCTGGAGG CTTGTAAACT AGGCGTGCCT GGTTTTTATC ACAATCAGGG 660

CTGCTATGAA CTGATCTCTG GTCCAATGAA CCGACACGCC TGGGGGGTTG CCTGGTTTGG 720

ATTTGCCATT CTCTGCTGGA CTTTTTGGGT TCTCCTGGGT ACCATGTTCT ACTGGAGCAG 780 AATTGAATAT TAAGAA

Seq ID NO: 42 Protein sequence: Protein Accession #: NP_008883.1

1 11 21 31 41 51

I 1 I 1 1 I

MAKDNSTVRC FQGLLIFGNV IIGCCGIALT AECIFFVSDQ HSLYPLLEAT DNDDIYGAAW 60

IGIFVGICLF CLSVLGIVGI MKSSRKILLA YFILMFIVYA FEVASCITAA TQRDFFTPNL 120

FLKQMLERYQ NNSPPNNDDQ WKNNGVTKTW DRLMLQDNCC GVNGPSD QK YTSAFRTENN 180

DADYPWPRQC CVMNNLKEPL NLEACKLGVP GFYHNQGCYE LISGPMNRHA WGVAWFGFAI 240 LCWTFWVLLG TMFYWSRIEY

Seq ID NO: 43 DNA sequence

Nucleic Acid Accession #: Eos sequence

Coding sequence: 83-2605

1 11 21 31 41 51 i i i i i i

GCCGGACAGA TCTGCGCGTA TCCTGGAGCC GGCCCAGTTG TGAACTAGGA GAGCTTTGGG 60

ACCTCTGTCC CAAGCAAGAG AGATGAATGG AGAGTATAGA GGCAGAGGAT TTGGACGAGG 120

AAGATTTCAA AGCTGGAAAA GGGGAAGAGG TGGTGGGAAC TTCTCAGGAA AATGGAGAGA 180

AAGAGAACAC AGACCTGATC TGAGTAAAAC CACAGGAAAA CGTACTTCTG AACAAACCCC 240 ACAGTTTTTG CTTTCAACAA AGACCCCACA GTCAATGCAG TCAACATTGG ATCGATTCAT 300

ACCATATAAA GGCTGGAAGC TTTATTTCTC TGAAGTTTAC AGCGATAGCT CTCCTTTGAT 360

TGAGAAGATT CAAGCATTTG AAAAATTTTT CACAAGGCAT ATTGATTTGT ATGACAAGGA 420

TGAAATAGAA AGAAAGGGAA GTATTTTGGT AGATTTTAAA GAACTGACAG AAGGTGGTGA 480

AGTAACTAAC TTGATACCAG ATATAGCAAC TGAACTAAGA GATGCACCTG AGAAAACCTT 540 GGCTTGCATG GGTTTGGCAA TACATCAGGT GTTAACTAAG GACCTTGAAA GGCATGCAGC 600

TGAGTTACAA GCCCAGGAAG GATTGTCTAA TGATGGAGAA ACAATGGTAA ATGTGCCACA 660

TATTCATGCA AGGGTGTACA ACTATGAGCC TTTGACACAG CTCAAGAATG TCAGAGCAAA 720

TTACTATGGA AAATACATTG CTCTAAGAGG GACAGTGGTT CGTGTCAGTA ATATAAAGCC 780

TCTTTGCACC AAGATGGCTT TTCTTTGTGC TGCATGTGGA GAAATTCAGA GCTTTCCTCT 840 TCCAGATGGA AAATACAGTC TTCCCACAAA GTGTCCTGTG CCTGTGTGTC GAGGCAGGTC 900

ATTTACTGCT CTCCGCAGCT CTCCTCTCAC AGTTACGATG GACTGGCAGT CAATCAAAAT 960

CCAGGAATTG ATGTCTGATG ATCAGAGAGA AGCAGGTCGG ATTCCACGAA CAATAGAATG 1020

TGAGCTTGTT CATGATCTTG TGGATAGCTG TGTCCCGGGA GACACAGTGA CTATTACTGG 1080

AATTGTCAAA GTCTCAAATG CGGAAGAAGG TTCTCGAAAT AAGAATGACA AGTGTATGTT 1140 CCTTTTGTAT ATTGAAGCAA ATTCTATTAG TAATAGCAAA GGACAGAAAA CAAAGAGTTC 1200

TGAGGATGGG TGTAAGCATG GAATGTTGAT GGAGTTCTCA CTTAAAGACC TTTATGCCAT 1260

CCAAGAGATT CAAGCTGAAG AAAACCTGTT TAAACTCATT GTCAACTCGC TTTGCCCTGT 1320

CATTTTTGGT CATGAACTTG TTAAAGCAGG TTTGGCATTA GCACTCTTTG GAGGAAGCCA 1380

GAAATACGCA GATGACAAAA ACAGAATTCC AATTCGGGGA GACCCCCACA TCCTTGTTGT 1440 TGGAGATCCA GGCCTAGGAA AAAGTCAAAT GCTACAGGCA GCGTGCAATG TTGCCCCACG 1500

TGGCGTGTAT GTTTGTGGTA ACACCACGAC CACCTCTGGT CTGACGGTAA CTCTTTCAAA 1560

AGATAGTTCC TCTGGAGATT TTGCTTTGGA AGCTGGTGCC CTGGTACTTG GTGATCAAGG 1620

TATTTGTGGA ATCGATGAAT TTGATAAGAT GGGGAATCAA CATCAAGCCT TGTTGGAAGC 1680

CATGGAGCAG CAAAGTATTA GTCTTGCTAA GGCTGGTGTG GTTTGTAGCC TTCCTGCAAG 1740 AACTTCCATT ATTGCTGCTG CAAATCCAGT TGGAGGACAT TACAATAAAG CCAAAACAGT 1800

TTCTGAGAAT TTAAAAATGG GGAGTGCACT ACTATCCAGA TTTGATTTGG TCTTTATCCT 1860

GTTAGATACT CCAAATGAGC ATCATGATCA CTTACTCTCT GAACATGTGA TTGCAATAAG 1920

AGCTGGAAAG CAGAGAACCA TTAGCAGTGC CACAGTAGCT CGTATGAATA GTCAAGATTC 1980

AAATACTTCC GTACTTGAAG TAGTTTCTGA GAAGCCATTA TCAGAAAGAC TAAAGGTGGT 2040 TCCTGGAGAA ACAATAGATC CCATTCCCCA CCAGCTATTG AGAAAGTACA TTGGCTATGC 2100

TCGGCAGTAT GTGTACCCAA GGCTATCCAC AGAAGCTGCT CGAGTTCTTC AAGATTTTTA 2160

CCTTGAGCTC CGGAAACAGA GCCAGAGGTT AAATAGCTCA CCAATCACTA CCAGGCAGCT 2220

GGAATCTTTG ATTCGTCTGA CAGAGGCACG AGCAAGGTTG GAATTGAGAG AGGAAGCAAC 2280

CAAAGAAGAC GCTGAGGATA TAGTGGAAAT TATGAAATAT AGCATGCTAG GAACTTACTC 2340 TGATGAATTT GGGAACCTAG ATTTTGAGCG ATCCCAGCAT GGTTCTGGAA TGAGCAACAG 2400

GTCAACAGCG AAAAGATTTA TTTCTGCTCT CAACAACGTT GCTGAAAGAA CTTATAATAA 2460

TATATTTCAA TTTCATCAAC TTCGGCAGAT TGCCAAAGAA CTAAACATTC AGGTTGCTGA 2520

TTTTGAAAAT TTTATTGGAT CACTAAATGA CCAGGGTTAC CTCTTGAAAA AAGGCCCAAA 2580

AGTTTACCAG CTTCAAACTA TGTAAAAGGA CTTCACCAAG TTAGGGCCTC CTGGGTTTAT 2640 TGCAGATTAA AGCCATCTCA GTGAAGATAT GCGTGCACGC ACAGACAGAC AGACACACAC 2700

ACACACACAC ACACACACAC ACACACACAC ACACACAGTC AAATACTGTT CTCTGAAAAA 2760

TGATGTCCCA AAAGTATTAT AATAGGAAAA AAGCATTAAA TATAATAAAC TAATTTAAGA 2820 AGTGATAAAG TCTCCAGATG CAGTAGCTCA CACTGTAATC ACAGTGACTC AGGAGGCTGA 2880

GGTGAGAGGA TTCCTTGAGG CCAGGGTTCG AGACCAACCT TGGGCAACAT AGCAAGACCC 2940

CATTTCTTAA AAAAAAAAAA AAAAAATTTA AACTTAGCTG GGTATGGTGG CACATGCCTA 3000

TAGTCTCAGC TACTTGTGAG GCTGAGGCAG GAGGATTCTT TGAGCCCAGG AGTTTGAGGT 3060

TACAGTGAGC CACAATCACA CCAATCACTG CACTCCAGCC TGGGCAATAA AGTAACTCTT 3120

GACTCAAAAA AATAAAAAAA ATTGTAGTGG TAGCCATGTG TTAATTGTTA AATAAATTCT 3180

CCAAAGGGCT AAAAGTAAAT TACTTATAAA TTTTTTATAG TTGTATTTTT GACCTGCCTT 3240

TTATATGTAT GAATATTTCA TAGTTTTGCA TATCAGATGT AGGCATACAG ACAAATACAT 3300

AAACCAATGA ATATATTACA TATTCTGTGT TCCAATAAAA CTTTATTTAT GGACACTAAA 3360

ATTTGAATTT CATAAAATTT TCCCATGTCA AGAATACAAA ATACTTGAGT TTTGTTTTTA 3420

GCTATTTAAT AATAGGTCTC ATTTATTCCA CAGGCTGTAG TTTGTAGTCT TGCTTGAAAC 3480

AATAGAAACA GACTGATTAA GCAGGAGAAG TTTTTTGAAA GAATTTTGTT TGGCTCACGG 3540

AATTATTAGA AGGCAGGTGA ACCAGGAGGG TAAGCTTCCA GCAGCAATTT GTAAAACCAT 3600

GCCTTAGAAT TGGACTAAGG AAGAAGCTGC TGACACTCCA CTGCCACACA GGGCACTGGA 3660

AGAAAGTGCT GCTGCCTCCC TGCCCCACCT TTGCCACTTC TGCAGCAGGA ATAGGTAGAA 3720

GAATGCCCCC ACCCGCACCG GAACAGCAAC AAAAGGATTC TGCATGAGAT GCCTCCCTAA 3780

ATTGCTGAAT TCAAAAAAGA AGTTGCATAC AAAGACATCT GATTGAAAAA GGGTATGTTA 3840

TATGCCCCTT TCATAGGCTG CTAGGGAGTT TTCCTGGTTC TACTTTCAGG TGGTGGGATC 3900

AATAAGACCA GAATTTCTCA TATGTTGTGA GAGGATTCAA ATGTTACAGG GTTGCCAGCC 3960

AAACTATCAA TCATGTATAA ATCCAACAAA CACTTTGTAA CATACAAGAA CTCAGGAAAT 4020

GTGAACCATT GTTGGAGAAT CTACTAAAAT ACGGCTTCCC GCAAACGAAG ATGAATGGAA 4080

AATGTAAATA AAAAGAACTG GCAGTGTATA TCAGATGTTT AACTATAGGA CCAGAACTAA 4140

GATGTGGAGA CTATTGCCAT AGACCACAAT GTAAATTTTT AAGTGAGGAA GGAAAAATCA 4200

GGAATCAAAA GGGGCCAGGT GCAGTGGCTC ACATCTATAA TCCCAGAGCT TTGGGAGTTC 4260

GAGGCAGGAG GATCACTTGA AGCCAGTTTT GAGACCAGCC TATGCAACAC ATTGAGACCC 4320

TATCTCTACA AAAAATAGAT TAGCTGGGCA CGGTGGTGCA TGCCTATTGT CCTACCTACT 4380

GTGGAGGCTG AAGTAGGAAA TCACTTGAGC CCGAGAGTTT GAGGTTACAG TGAGCTATGA 4440 TTATACCACT GCACTCCAGC CTGGGCAAGA GAGCAAGACC TTGTCTCTT

Seq ID NO: 44 Protein sequence: Protein Accession #: CAB55276.2

11 21 31 41 51

1 I I

MNGEYRGRGF GRGRFQS KR G IRGGGNFSGK WREREHRPDL S IKTTGKRTSE QTPQFLLSTK 60 TPQSMQSTLD RFIPYKG KL YFSEVYSDSS PLIEKIQAFE KFFTRHIDLY DKDEIERKGS 120 ILVDFKELTE GGEVTNLIPD IATELRDAPE KTLACMGLAI HQVLTKDLER HAAELQAQEG 180 LSNDGETMVN VPHIHARVYN YEPLTQLKNV RANYYGKYIA LRGTWRVSN I PLCTKMAF 240 LCAACGEIQS FPLPDGKYSL PTKCPVPVCR GRSFTALRSS PLTVTMDWQS IKIQELMSDD 300 QREAGRIPRT IECELVHDLV DSCVPGDTVT ITGIVKVSNA EEGSRNKNDK CMFLLYIEAN 360 SISNSKGQKT KSSEDGCKHG MLMEFSLKDL YAIQEIQAEE NLFKLIVNSL CPVIFGHELV 420 KAGLALALFG GSQKYADDKN RIPIRGDPHI LWGDPGLGK SQMLQAACNV APRGVYVCGN 480 TTTTSGLTVT LSKDSSSGDF ALEAGALVLG DQGICGIDEF DKMGNQHQAL LEAMEQQSIS 540 LAKAGWCSL PARTS11AAA NPVGGHYNKA KTVSENLKMG SALLSRFDLV FILLDTPNEH 600 HDHLLSEHVI AIRAGKQRTI SSATVARMNS QDSNTSVLEV VSEKPLSERL KWPGETIDP 660 IPHQLLRKYI GYARQYVYPR LSTEAARVLQ DFYLELRKQS QRLNSSPITT RQLESLIRLT 720 EARARLELRE EATKEDAEDI VEIMKYSMLG TYSDEFGNLD FERSQHGSGM SNRSTAKRFI 780 SALNNVAERT YNNIFQFHQL RQIAKELNIQ VADFENFIGS LNDQGYLLKK GPKVYQLQTM

Seq ID NO: 45 DNA sequence

Nucleic Acid Accession #: NM_005416.1

Coding sequence: 149..658

11 21 31 41 51

ACCAGATCCC AGAGGCTGAA CACCTCGACC TTCTCTGCAC AGCAGATGAT CCCTGAGCAG 60 CTGAAGACCA GAAAAGCCAC TAAGACTTTC TGCTTAATTC AGGAGCTTAG AGGATTCTTC 120 AAAGAGTGTG TCCACGATCC TTTGAAGCAT GAGTTCTTAC CAGCAGAAGC AGACCTTTAC 180 CCCACCACCT CAGCTTCAAC AGCAGCAGGT GAAACAACCC AGCCAGCCTC CACCTCAGGA 240 AATATTTGTT CCCACAACCA AGGAGCCATG CCACTCAAAG GTTCCACAAC CTGGAAACAC 300 AAAGATTCCA GAGCCAGGCT GTACCAAGGT CCCTGAGCCA GGCTGTACCA AGGTCCCTGA 360 GCCAGGCTGT ACCAAGGTCC CTGAGCCAGG TTGTACCAAG GTCCCTGAGC CAGGCTGTAC 420 CAAGGTCCCT GAGCCAGGTT GTACCAAGGT CCCTGAGCCA GGCTACACCA AGGTCCCTGA 480 ACCAGGCAGC ATCAAGGTCC CTGACCAAGG CTTCATCAAG TTTCCTGAGC CAGGTGCCAT 540 CAAAGTTCCT GAGCAAGGAT ACACCAAAGT TCCTGTGCCA GGCTACACAA AGCTACCAGA 600 GCCATGTCCT TCAACGGTCA CTCCAGGCCC AGCTCAGCAG AAGACCAAGC AGAAGTAATT 660 TGGTGCACAG ACAAGCCCTT GAGAAGCCAA CCACCAGATG CTGGACACCC TCTTCCCATC 720 TGTTTCTGTG TCTTAATTGT CTGTAGACCT TGTAATCAGC ACATTGTCAC CCCAAGCCAT 780 AGTCTCTCTC TTATTTGTAT CCTAAAAATA CGTACTATAA AGCTTTTGTT CACACACACT 840 CTGAAGAATC CTGTAAGCCC CTGAATTAAG CAGAAAGTCT TCATGGCTTT TCTGGTCTTC 900 GGCTGCTCAG GGTTCATCTG AAGATTCGAA TGAAAAGAAA TGCATGTTTC CTGCTCTTCC 960 CTCATTAAAT TGCTTTTAAT TCCA

Seq ID NO: 46 Protein sequence: Protein Accession #: NP 005407.1

1 11 21 31 41 51

I I I I I I

MSSYQQKQTF TPPPQLQQQQ VKQPSQPPPQ EIFVPTTKEP CHSKVPQPGN TKIPEPGCTK 60 VPEPGCTKVP EPGCTKVPEP GCTKVPEPGC TKVPEPGCTK VPEPGYTKVP EPGSIKVPDQ 120 GFIKFPEPGA IKVPEQGYTK VPVPGYTKLP EPCPSTVTPG PAQQKTKQK

Seq ID NO: 47 DNA sequence

Nucleic Acid Accession #: Eos sequence 1 11 21 31 41 51

G ICGTCGTGTG CIAGGCGTCCC CIGGGCTGTGG AITAATTAGAC AICGTTCTTCC CITCATTGCCC 60

AAGGCTCGTT AGAATTCGCC CTAGAGCTGT ATCATGTATT TTCTTTCAAA TTAACTTTGC 120

TTGCAATTAA GCTTAGGGAA CCAGCAACAA AAGCAAACTT GGCCCGAGGT CGTTCACCGC 180

GAAAATGGAT TAGAGAAACT TCTTCCCCGA TTTAAGGGGA AAGATTCCTG CGGCCAGCGC 240

TTTGGGGAAA GTGCCCCGAC CGCAGAGGCG ACGACAGGGG AGCAGGAAGC TGCTCACGGT 300

AGTCGGCGTT GGCGGCAGCG GTGGCCTTCC TCATCTGGGC GATGTGGGCT CCTAGAAGAG 360

TAAGGATAAC ATCCTGGAAA TGACTTCTGT ACGGTTTGAG CCCAACTGCA CACTCATGAC 420

TTGGAGCTGC CCTGTGGAGT TACAGTTTAC CAAACACATT CATGAACATA ATCTCATTTA 480 CTAAAAACTT TGTGAGAATT TTCTTTTACT AAAATTTTTT CTTATTACAA A

Seq ID NO: 48 DNA sequence:

Nucleic Acid Accession #: CAT cluster

1 11 21 31 41 51

T ITCCAAATTT TITTTTTTTGT AIATAAGAAAA AIATTTTAGTA AIAAGAAAATT CITCACAAAGT 60

TTTTAGTAAA TGAGATTATG TTCATGAATG TGTTTGGTAA ACTGTAACTC CACAGGGCAG 120

CTCCAAGTCA TGAGTGTGCA GTTGGGCTCA AACCGTACAG AAGTCATTTC CAGGATGTTA 180

TCCTTACTCT TCTCGGAGCC CACATCGCCC AGATGAGGAA GGCCACCGCT GCCGCCAACG 240

CCGACTACCG TGAGCAGCTT CCTGCTCCCC TGTCGTCGCC TCTGCGGTCG GGGCACTTTC 300

CCCAAAGCGC TGGCCGCAGG AATCTTTCCC CTTAAATCGG GGAAGAAGTT TCTCTAATCC 360

ATTTTCGCGG TGAACGACCT CGGGCCAAGT TTGCTTTTGT TGCTGGTTCC CTAAGCTTAA 420

TTGCAAGCAA AGTTAATTTG AAAGAAAATA CATGATACAG CTCTAGGGCG AATTCTAACG 480

AGCCTTGGGC AATGAGGGAA GAACGTGTCT AGTTATCCAC AGCCCGGGGA CGCCTGCACA 540 CGACGCT

Seq ID NO: 49 DNA sequence

Nucleic Acid Accession #: CAT cluster

1 11 21 31 41 51

I I I I 1 I

TCTTTCTTCT GCTGCTCGTT TGTCTCTCCT GTGCTCTTCT TCTTTCTTTC CCTCGCCGCT 60

CCTGCCGACC TCTGTTGTCT CTTCTCTGAT GGCGGGGGGC GGGAGAAGCT GACCGGTGAG 120

ACCGTAGACC CGAAACCATT GGGTGTCACA AGCCGGTCGC CGGCTTTTTT GGGAGAACCC 180

GACACATGCA GACCAGTTTT CCTGGAACNG CATGACCATG TTATTACTAT GGGCCGCCTC 240

CCCAACCAAA GTGTTTAAAA CTTTTTAGGG CACCCCCAAA ATTTTTTTTT TTTTTTTTTT 300

TTCATTTAAA AAACTCTAAT ATTTATATTA AATACAAAGA TACCCAAACC CTTTATGCTT 360

CTTTCTCTGA TCTGTGTCTT TTTTCTTTGA CAGCATCTCC ATTTTTTTTC TGCTGCTTCA 420

TCGCTGTAGC CATGGGAATC CGTTTCATTA TTATGGTAGC AATATGGAGT GCTGTATTCC 480

TAAAGAAACT GACACAGGAG AATCACTTGA ACTTGGGAGG CAGAGTTTGC AGTGAGCCGA 540

GATTGAACCA GTGCACTCCA GCCTTGGCAG CGGAGCAAGA TTCTGTCACA GTTCCTGAAG 600

TGCTGGTATC GTCCTGCAGC CCCATCCTCG GTTCCATTGC GCTGCCAGGC AGGGTGCTGG 660

GACGTGGGGA GAGCTGGTCT ATATATCCGG GTGAAGCTCA GCTGTGGCAC ACCTTGGATG 720

CCGGGTCTCT CCTGGCCCCG GGGACCTAGT ATTTTTGCCA CGAGTGTACA CCAAACAAAG 780

GAGACAGCAT CATTTATGAG CCTGCAGCAT CCACCCTACT GCTGTATCCA GTTTCCATTG 840 ACTG

Seq ID NO: 50 DNA sequence Nucleic Acid Accession #: L05187 Coding sequence: 1991..2260

1 11 21 31 41 51

C ITGCAGGGAG GICAGGTAGAA AIAGGCTTTTG GIGTTTTCAGG TIGGGGGGCAG TICTAGCCTGA 60

TCAGAAAGGA GGAAAAGGCC AGGGCAGATG TCTGGGTGGA GTGAAGGGAA AAAGTGATCC 120

CAGAAGAAGG ATTAGCCCCT GAAAGTCCCT GAAGTAGGAG AAGGGTAAAG GTGTGGTTGG 180

TGAAGGAAAG CAGGTTTTCC CAGATTAGCA ACCAGTCAGG GGGAGGAAGG TGAGAGTGGG 240

AGAGTCATAA GTAAATTATT CTGAATGTGT GTAGTTTAAT GGAATTGGGA AAAAGATGGG 300

GGAAATGGAT GGAAGGTCTT GGACTCTGAG ACAAGGGGTC TATAATCAGT CCATTTCATT 360

ATTTCTAGCT TCCACCTTCA CCAAGGCAGA CAAGGAGGGC CCACCTCAGC TCCTCTGCTC 420

CCCCTCCCTT TCCCACCTAT TCATGTGTGC AAGAGTGCCC TGTCCCACAG AACACGGGGA 480 ACAACCATCT CAATGACAAG GACAGCAGGT GGCAAGGCTC AACAGGACTC AGATGTCCCC 540

CCAGGGTTAA CTCATGAAAC CCTCCATGAA GCCTGCTGCT CACCCCTCCC TCAAGGCAAG 600

CCCTGCACCT GGGTCTGAGG ATGAGGGTGG CAGTGAAAAT TAGGCCAGTG ACATCATTTT 660

CAGCCAGCTA GTGCCAAAAA ATATCAGGTG GTGTTCATCA AATAAGCCGA GCCAACCGGT 720

GATGAGGATG GTAGTGTGAG TCATGTGTGA CAGGTGAGGA ATGAAAACAG AGTGCCCGAG 780

AGCTTCTATT TCCTTGAGGC AGGGCTCATT CATCTTATAA AAGCCAGCTG GCCATTGCCT 840

TCACACCAAA CCCAAGGGAC CACACAGCCC ATTCTGCTCC GTATACCAGG TAAGTCTCTG 900

ATTGCAACAA ACTGGCAATT CTAGTGTACT TTTTCATTAT TAGAAATTAG CTAAAGGCAA 960

ATATGTGTAA GCAGGTTAAT CCAGGGTTTC AATGGGAGAT AGAGAATAGT GGAATATCTT 1020

TATTTTAAGT TAAATTACAG TCTGGATTTG AAAGGACCTT AGAGATGGTT AGGGCTCCCA 1080

CCTCAGTAGA TAGTCATTGA ACTGGGAGTC CTGGAGAAGA TTGTTCAAAT GCCCATGGGA 1140

AGTTCATAGC AGAACTAGAA CTCAGGCCAG AGCACTCTCA GTAACACTGC AATTTCCCCC 1200

TGACAAGATA TTTATAGAAA TTTTAATTTA TTAGATGGAT CTCTACTGAG CATTTATTCC 1260

ATTTAAGGCA GTATGCTAGG CACTTTGGAC AAATCAATGC CCTAACGTAC TTACTTAACA 1320

AACATAAAAC CTAGCAGGAA GGTAATACAT ATATATAAAT AASTGAAATG CAAAGTAGAT 1380

AGTAATTGGC ATGACGGAGA TGGGCAGAGA AGGGCTGTGC ACTTTTGGGA GACTTGCTCA 1440

AGGAGACCTC TAGGGTGTCA AGTGATGTGA GCTATGATGG AGGGGTATTT GGACAAGCAG 1500

AGATGGGAAG AAAAGCATTT GGAAGGGACT GTGTAAGCAC AGACCAGAAG CAAAACCATA 1560

GAGGCTTAGA TGAATATAAA GCCATCCTAT AAGTCACAGG CTTTCTACAT GGTACTAGGA 1620

GAGGAAAGTG GTCTGATGCC ATTTTCCAAA AGACCTAATA TGCGGACCTC ATGTCCCTCA 1680

GAAGCCAGCT TTAGTAGGGC ATTTTTCCAG AACAGATATA AGGTGCCTTG GGTAGGAAGG 1740

GAGCCAAGAA GAGAACTCCA ATAAAATGGA GCAGAAGAAA TTGCCTTTTA GCTCCTCCTC 1800

TTCAAAGGGC CTGAAAATTA TCCAAGCTTA TTTCATTTTT AAATGTAATG GGGGAGCTAA 1860 GGGAGATGAA AGGCTTTCTC TTCTAAAGGG TCCTGAAATA AAATCTGTTT GGCATTGAAT 1920

TTGTATCCAT CTTTCTTTAA TTGAATCACT GTGTCAGCTT TCTGTCTCTA GAAAAAAACA 1980

CATTTGAAGC ATGAATTCTC AGCAGCAGAA GCAGCCTTGC ACCCCACCCC CTCAGCCTCA 2040

GCAGCAGCAG GTGAAACAAC CTTGCCAGCC TCCACCCCAG GAACCATGCA TCCCCAAAAC 2100

CAAGGAGCCC TGCCAACCCA AGGTGCCTGA GCCCTGCCAC CCCAAAGTGC CTGAGCCCTG 2160

CCAGCCCAAG ATTCCAGAGC CCTGCCAGCC CAAGGTGCCT GAGCCCTGCC CTTCAACGGT 2220

CACTCCAGCA CCAGCCCAGC AGAAGACCAA GCAGAAGTAA TGTGGTCCAC AGCCATGCCC 2280

TTGAGGAGCT GGGCACTGGA TACTGAACAC CCTACTCCAT TCTGCTTATG AATCCCATTT 2340

GCCTATTGAC CCTGCAGTTA GCATGCTGTC ACCCTGAATC ATAATCGCTC CTTTGCACCT 2400

CTAAAAAGAT GTCCCTTACC CTCATTCTGG AGGCTCCTGA GCCTCTGCGT AAGGCTGAAC 2460

GTCTCACTGA CTGAGCTAGT CTTCTTGTTG CTCGGGTGCA TTTGAGGATG GATTTGGGGA 2520 AGGTCAAGTG ACCATCCCTA G

Seq ID NO: 51 Protein sequence: Protein Accession #:AAC26838

1 11 21 31 41 51

I I I I I I

MNSQQQKQPC TPPPQPQQQQ VKQPCQPPPQ EPCIPKTKEP CQPKVPEPCH PKVPEPCQPK 60 IPEPCQPKVP EPCPSTVTPA PAQQKTKQK

Seq ID NO: 52 DNA sequence

Nucleic Acid Accession #: NM_002638.1

Coding sequence: 120-473

1 11 21 31 41 51

I I I I I I

CAATACAGCT AAGGAATTAT CCCTTGTAAA TACCACAGAC CCGCCCTGGA GCCAGGCCAA 60

GCTGGACTGC ATAAAGATTG GTATGGCCTT AGCTCTTAGC CAAACACCTT CCTGACACCA 120

TGAGGGCCAG CAGCTTCTTG ATCGTGGTGG TGTTCCTCAT CGCTGGGACG CTGGTTCTAG 180

AGGCAGCTGT CACGGGAGTT CCTGTTAAAG GTCAAGACAC TGTCAAAGGC CGTGTTCCAT 240

TCAATGGACA AGATCCCGTT AAAGGACAAG TTTCAGTTAA AGGTCAAGAT AAAGTCAAAG 300

CGCAAGAGCC AGTCAAAGGT CCAGTCTCCA CTAAGCCTGG CTCCTGCCCC ATTATCTTGA 360

TCCGGTGCGC CATGTTGAAT CCCCCTAACC GCTGCTTGAA AGATACTGAC TGCCCAGGAA 420

TCAAGAAGTG CTGTGAAGGC TCTTGCGGGA TGGCCTGTTT CGTTCCCCAG TGAAGGGAGC 480

CGGTCCTTGC TGCACCTGTG CCGTCCCCAG AGCTACAGGC CCCATCTGGT CCTAAGTCCC 540

TGCTGCCCTT CCCCTTCCCA CACTGTCCAT TCTTCCTCCC ATTCAGGATG CCCACGGCTG 600 GAGCTGCCTC TCTCATCCAC TTTCCAATAA A

Seq ID NO: 53 Protein sequence: Protein Accession #: NP_002629.1

1 11 21 31 41 51 i i i i i i

MRASSFLIW VFLIAGTLVL EAAVTGVPVK GQDTVKGRVP FNGQDPVKGQ VSVKGQDKVK 60 AQEPVKGPVS TKPGSCPIIL IRCAMLNPPN RCLKDTDCPG IKKCCEGSCG MACFVPQ

Seq ID NO: 54 DNA sequence Nucleic Acid Accession # : NM_019618 Coding sequence : 75-584

1 11 21 31 41 51

I 1 I I 1 1

GGCACGAGCC ACGATTCAGT CCCCTGGACT GTAGATAAAG ACCCTTTCTT GCCAGGTGCT 60

GAGACAACCA CACTATGAGA GGCACTCCAG GAGACGGTGA TGGTGGAGGA AGGGCCGTCT 120

ATCAATCAAT GTGTAAACCT ATTACTGGGA CTATTAATGA TTTGAATCAG CAAGTGTGGA 180

CCCTTCAGGG TCAGAACCTT GTGGCAGTTC CACGAAGTGA CAGTGTGACC CCAGTCACTG 240

TTGCTGTTAT CACATGCAAG TATCCAGAGG CTCTTGAGCA AGGCAGAGGG GATCCCATTT 300

ATTTGGGAAT CCAGAATCCA GAAATGTGTT TGTATTGTGA GAAGGTTGGA GAACAGCCCA 360

CATTGCAGCT AAAAGAGCAG AAGATCATGG ATCTGTATGG CCAACCCGAG CCCGTGAAAC 420

CCTTCCTTTT CTACCGTGCC AAGACTGGTA GGACCTCCAC CCTTGAGTCT GTGGCCTTCC 480

CGGACTGGTT CATTGCCTCC TCCAAGAGAG ACCAGCCCAT CATTCTGACT TCAGAACTTG 540

GGAAGTCATA CAACACTGCC TTTGAATTAA ATATAAATGA CTGAACTCAG CCTAGAGGTG 600

GCAGCTTGGT CTTTGTCTTA AAGTTTCTGG TTCCCAATGT GTTTTCGTCT ACATTTTCTT 660

AGTGTCATTT TCACGCTGGT GCTGAGACAG GGGCAAGGCT GCTGTTATCA TCTCATTTTA 720

TAATGAAGAA GAAGCAATTA CTTCATAGCA ACTGAAGAAC AGGATGTGGC CTCAGAAGCA 780

GGAGAGCTGG GTGGTATAAG GCTGTCCTCT CAAGCTGGTG CTGTGTAGGC CACAAGGCAT 840

CTGCATGAGT GACTTTAAGA CTCAAAGACC AAACACTGAG CTTTCTTCTA GGGGTGGGTA 900

TGAAGATGCT TCAGAGCTCA TGCGCGTTAC CCACGATGGC ATGACTAGCA CAGAGCTGAT 960

CTCTGTTTCT GTTTTGCTTT ATTCCCTCTT GGGATGATAT CATCCAGTCT TTATATGTTG 1020

CCAATATACC TCATTGTGTG TAATAGAACC TTCTTAGCAT TAAGACCTTG TAAACAAAAA 1080

TAATTCTTGT GTTAAGTTAA ATCATTTTTG TCCTAATTGT AATGTGTAAT CTTAAAGTTA 1140 AATAAACTTT GTGTATTTAT ATAATAAAAA AAAAAAAAAA AAA

Seq ID NO: 55 Protein sequence: Protein Accession # : NP_062564

1 11 21 31 41 51 I I I I I 1

MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT 60 CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY 120 RAKTGRTSTL ESVAFPD FI ASSKRDQPII LTSELGKSYN TAFELNIND Seq ID NO: 56 DNA sequence

Nucleic Acid Accession #: NM_003125 Coding sequence: 65-334 11 21 31 41 51

AGCAGTTCTA AGGGACCATA CAGAGTATTC CTCTCTTCAC ACCAGGACCA GCCACTGTTG 60 CAGCATGAGT TCCCAGCAGC AGAAGCAGCC CTGCATCCCA CCCCCTCAGC TTCAGCAGCA 120 GCAGGTGAAA CAGCCTTGCC AGCCTCCACC TCAGGAACCA TGCATCCCCA AAACCAAGGA 180 GCCCTGCCAC CCCAAGGTGC CTGAGCCCTG CCACCCCAAA GTGCCTGAGC CCTGCCAGCC 240 CAAGCTTCCA GAGCCATGCC ACCCCAAGGT GCCTGAGCCC TGCCCTTCAA TAGTCACTCC 300 AGCACCAGCC CAGCAGAAGA CCAAGCAGAA GTAATGTGGT CCACAGCCAT GCCCTTGAGG 360 AGCCGGCCAC CAGATGCTGA ATCCCCTATC CCATTCTGTG TATGAGTCCC ATTTGCCTTG 420 CAATTAGCAT TCTGTCTCCC CCAAAAAAGA ATGTGCTATG AAGCTTTCTT TCCTACACAC 480 TCTGAGTCTC TGAATGAAGC TGAAGGTCTT AGTACCAGAG CTAGTTTTCA GCTGCTCAGA 540 ATTCATCTGA AGAGAGACTT AAGATGAAAG CAAATGATTC AGCTCCCTTA TACCCCCATT 600 AAATTCACTT TCAATTCCA

Seq ID NO: 57 Protein sequence: Protein Accession #: NP_003116

1 11 21 31 41 51

1 I I 1 I 1

MSSQQQKQPC IPPPQLQQQQ VKQPCQPPPQ EPCIPKTKEP CHPKVPEPCH PKVPEPCQPK 60 LPEPCHPKVP EPCPSIVTPA PAQQKTKQK

Seq ID NO: 58 DNA sequence

Nucleic Acid Accession #: NM_001793.2

Coding sequence: 71-2560

11 21 31 41 51

AAAGGGGCAA GAGCTGAGCG GAACACCGGC CCGCCGTCGC GGCAGCTGCT TCACCCCTCT 60 CTCTGCAGCC ATGGGGCTCC CTCGTGGACC TCTCGCGTCT CTCCTCCTTC TCCAGGTTTG 120 CTGGCTGCAG TGCGCGGCCT CCGAGCCGTG CCGGGCGGTC TTCAGGGAGG CTGAAGTGAC 180 CTTGGAGGCG GGAGGCGCGG AGCAGGAGCC CGGCCAGGCG CTGGGGAAAG TATTCATGGG 240 CTGCCCTGGG CAAGAGCCAG CTCTGTTTAG CACTGATAAT GATGACTTCA CTGTGCGGAA 300 TGGCGAGACA GTCCAGGAAA GAAGGTCACT GAAGGAAAGG AATCCATTGA AGATCTTCCC 360 ATCCAAACGT ATCTTACGAA GACACAAGAG AGATTGGGTG GTTGCTCCAA TATCTGTCCC 420 TGAAAATGGC AAGGGTCCCT TCCCCCAGAG ACTGAATCAG CTCAAGTCTA ATAAAGATAG 480 AGACACCAAG ATTTTCTACA GCATCACGGG GCCGGGGGCA GACAGCCCCC CTGAGGGTGT 540 CTTCGCTGTA GAGAAGGAGA CAGGCTGGTT GTTGTTGAAT AAGCCACTGG ACCGGGAGGA 600 GATTGCCAAG TATGAGCTCT TTGGCCACGC TGTGTCAGAG AATGGTGCCT CAGTGGAGGA 660 CCCCATGAAC ATCTCCATCA TCGTGACCGA CCAGAATGAC CACAAGCCCA AGTTTACCCA 720 GGACACCTTC CGAGGGAGTG TCTTAGAGGG AGTCCTACCA GGTACTTCTG TGATGCAGGT 780 GACAGCCACG GATGAGGATG ATGCCATCTA CACCTACAAT GGGGTGGTTG CTTACTCCAT 840 CCATAGCCAA GAACCAAAGG ACCCACACGA CCTCATGTTC ACCATTCACC GGAGCACAGG 900 CACCATCAGC GTCATCTCCA GTGGCCTGGA CCGGGAAAAA GTCCCTGAGT ACACACTGAC 960 CATCCAGGCC ACAGACATGG ATGGGGACGG CTCCACCACC ACGGCAGTGG CAGTAGTGGA 1020 GATCCTTGAT GCCAATGACA ATGCTCCCAT GTTTGACCCC CAGAAGTACG AGGCCCATGT 1080 GCCTGAGAAT GCAGTGGGCC ATGAGGTGCA GAGGCTGACG GTCACTGATC TGGACGCCCC 1140 CAACTCACCA GCGTGGCGTG CCACCTACCT TATCATGGGC GGTGACGACG GGGACCATTT 1200 TACCATCACC ACCCACCCTG AGAGCAACCA GGGCATCCTG ACAACCAGGA AGGGTTTGGA 1260 TTTTGAGGCC AAAAACCAGC ACACCCTGTA CGTTGAAGTG ACCAACGAGG CCCCTTTTGT 1320 GCTGAAGCTC CCAACCTCCA CAGCCACCAT AGTGGTCCAC GTGGAGGATG TGAATGAGGC 1380 ACCTGTGTTT GTCCCACCCT CCAAAGTCGT TGAGGTCCAG GAGGGCATCC CCACTGGGGA 1440 GCCTGTGTGT GTCTACACTG CAGAAGACCC TGACAAGGAG AATCAAAAGA TCAGCTACCG 1500 CATCCTGAGA GACCCAGCAG GGTGGCTAGC CATGGACCCA GACAGTGGGC AGGTCACAGC 1560 TGTGGGCACC CTCGACCGTG AGGATGAGCA GTTTGTGAGG AACAACATCT ATGAAGTCAT 1620 GGTCTTGGCC ATGGACAATG GAAGCCCTCC CACCACTGGC ACGGGAACCC TTCTGCTAAC 1680 ACTGATTGAT GTCAATGACC ATGGCCCAGT CCCTGAGCCC CGTCAGATCA CCATCTGCAA 1740 CCAAAGCCCT GTGCGCCAGG TGCTGAACAT CACGGACAAG GACCTGTCTC CCCACACCTC 1800 CCCTTTCCAG GCCCAGCTCA CAGATGACTC AGACATCTAC TGGACGGCAG AGGTCAACGA 1860 GGAAGGTGAC ACAGTGGTCT TGTCCCTGAA GAAGTTCCTG AAGCAGGATA CATATGACGT 1920 GCACCTTTCT CTGTCTGACC ATGGCAACAA AGAGCAGCTG ACGGTGATCA GGGCCACTGT 1980 GTGCGACTGC CATGGCCATG TCGAAACCTG CCCTGGACCC TGGAAGGGAG GTTTCATCCT 2040 CCCTGTGCTG GGGGCTGTCC TGGCTCTGCT GTTCCTCCTG CTGGTGCTGC TTTTGTTGGT 2100 GAGAAAGAAG CGGAAGATCA AGGAGCCCCT CCTACTCCCA GAAGATGACA CCCGTGACAA 2160 CGTCTTCTAC TATGGCGAAG AGGGGGGTGG CGAAGAGGAC CAGGACTATG ACATCACCCA 2220 GCTCCACCGA GGTCTGGAGG CCAGGCCGGA GGTGGTTCTC CGCAATGACG TGGCACCAAC 2280 CATCATCCCG ACACCCATGT ACCGTCCTCG GCCAGCCAAC CCAGATGAAA TCGGCAACTT 2340 TATAATTGAG AACCTGAAGG CGGCTAACAC AGACCCCACA GCCCCGCCCT ACGACACCCT 2400 CTTGGTGTTC GACTATGAGG GCAGCGGCTC CGACGCCGCG TCCCTGAGCT CCCTCACCTC 2460 CTCCGCCTCC GACCAAGACC AAGATTACGA TTATCTGAAC GAGTGGGGCA GCCGCTTCAA 2520 GAAGCTGGCA GACATGTACG GTGGCGGGGA GGACGACTAG GCGGCCTGCC TGCAGGGCTG 2580 GGGACCAAAC GTCAGGCCAC AGAGCATCTC CAAGGGGTCT CAGTTCCCCC TTCAGCTGAG 2640 GACTTCGGAG CTTGTCAGGA AGTGGCCGTA GCAACTTGGC GGAGACAGGC TATGAGTCTG 2700 ACGTTAGAGT GGTTGCTTCC TTAGCCTTTC AGGATGGAGG AATGTGGGCA GTTTGACTTC 2760 AGCACTGAAA ACCTCTCCAC CTGGGCCAGG GTTGCCTCAG AGGCCAAGTT TCCAGAAGCC 2820 TCTTACCTGC CGTAAAATGC TCAACCCTGT GTCCTGGGCC TGGGCCTGCT GTGACTGACC 2880 TACAGTGGAC TTTCTCTCTG GAATGGAACC TTCTTAGGCC TCCTGGTGCA ACTTAATTTT 2940 TTTTTTTAAT GCTATCTTCA AAACGTTAGA GAAAGTTCTT CAAAAGTGCA GCCCAGAGCT 3000 GCTGGGCCCA CTGGCCGTCC TGCATTTCTG GTTTCCAGAC CCCAATGCCT CCCATTCGGA 3060 TGGATCTCTG CGTTTTTATA CTGAGTGTGC CTAGGTTGCC CCTTATTTTT TATTTTCCCT 3120 GTTGCGTTGC TATAGATGAA GGGTGAGGAC AATCGTGTAT ATGTACTAGA ACTTTTTTAT 3180 TAAAGAAACT TTTCCCAGAA AAAAA

Seq ID NO: 59 Protein sequence: Protein Accession #: NP 001784.2

11 21 31 41 51

MGLPRGPLAS LLLLQVCWLQ CAASEPCRAV FREAEVTLEA GGAEQEPGQA LGKVFMGCPG 60 QEPALFSTDN DDFTVRNGET VQERRSLKER NPLKIFPSKR ILRRHKRDWV VAPISVPENG 120 KGPFPQRLNQ LKSNKDRDTK IFYSITGPGA DSPPEGVFAV EKETGWLLLN KPLDREEIAK 180 YELFGHAVSE NGASVEDPMN ISIIVTDQND HKPKFTQDTF RGSVLEGVLP GTSVMQVTAT 240 DEDDAIYTYN GWAYSIHSQ EPKDPHDLMF TIHRSTGTIS VISSGLDREK VPEYTLTIQA 300 TDMDGDGSTT TAVAWEILD ANDNAPMFDP QKYEAHVPEN AVGHEVQRLT VTDLDAPNSP 360 AWRATYLIMG GDDGDHFTIT THPESNQGIL TTRKGLDFEA KNQHTLYVEV TNEAPFVLKL 420 PTSTATIWH VEDVNEAPVF VPPSKWEVQ EGIPTGEPVC VYTAEDPDKE NQKISYRILR 480 DPAGWLAMDP DSGQVTAVGT LDREDEQFVR NNIYEVMVLA MDNGSPPTTG TGTLLLTLID 540 VNDHGPVPEP RQITICNQSP VRQVLNITDK DLSPHTSPFQ AQLTDDSDIY WTAEVNEEGD 600 TWLSLKKFL KQDTYDVHLS LSDHGNKEQL TVIRATVCDC HGHVETCPGP KGGFILPVL 660 GAVLALLFLL LVLLLLVRKK RKIKEPLLLP EDDTRDNVFY YGEEGGGEED QDYDITQLHR 720 GLEARPEWL RNDVAPTIIP TPMYRPRPAN PDEIGNFIIE NLKAANTDPT APPYDTLLVF 780 DYEGSGSDAA SLSSLTSSAS DQDQDYDYLN EWGSRFKKLA DMYGGGEDD

Seq ID NO: 60 DNA sequence

Nucleic Acid Accession #: Eos sequence

Coding sequence: 162-428

11 21 31 41 51

I I I I

GCGTTCCGTT G 1GCGGCGGAT TCGAACGTTC GGACTGAGGT TTTTCTGCCT GAAGAAGCGT 60 CATACGGACC GGATTGTTTT CGCTGGCCCA GTGTCCCCGG AGCTTGTGTG CGATACAGAG 120 AGCACCTCGG AAGCTGAGGC AGCTGGTACT TGAGAGAGAG GATGGCGCTG TCGACCATAG 180 TCTCCCAGAG GAAGCAGATA AAGCGGAAGG CTCCCCGTGG CTTTCTAAAG CGAGTCTTCA 240 AGCGAAAGAA GCCTCAACTT CGTCTGGAGA AAAGTGGTGA CTTATTGGTC CATCTGAACT 300 GTTTACTGTT TGTTCATCGA TTAGCAGAAG AGTCCAGGAC AAACGCTTGT GCGAGTAAAT 360 GTAGAGTCAT TAACAAGGAG CATGTACTGG CCGCAGCAAA GGTAATTCTA AAGAAGAGCA 420 GAGGTTAGAA GTCAAAGAAC ATATTCTTGA AAGTTATGAT GCATTCTTTT GGGTGGTAAC 480 AGATCATAAA GACATTTTTT ACACATCAGT TAATATGGGA TTATTAAATA TTGG

Seq ID NO: 61 Protein sequence: Protein Accession #: Eos sequence

1 11 21 31 41 51

I I I I I I

MALSTIVSQR KQIKRKAPRG FLKRVFKRKK PQLRLEKSGD LLVHLNCLLF VHRLAEESRT 60 NACASKCRVI NKEHVLAAAK VILKKSRG

Seq ID NO: 62 DNA sequence Nucleic Acid Accession # : NM_000094.2

Coding sequence: 99-8933

11 21 31 41 51

I I 1 I

GGGCTGGAGG GGCGCTGGGC TCGGACCTGC CAAGGCCACC GCAGGGGGGA GCAAGGGACA 60 GAGGCGGGGG TCCTAGCTGA CGGCTTTTAC TGCCTAGGAT GACGCTGCGG CTTCTGGTGG 120 CCGCGCTCTG CGCCGGGATC CTGGCAGAGG CGCCCCGAGT GCGAGCCCAG CACAGGGAGA 180 GAGTGACCTG CACGCGCCTT TACGCCGCTG ACATTGTGTT CTTACTGGAT GGCTCCTCAT 240 CCATTGGCCG CAGCAATTTC CGCGAGGTCC GCAGCTTTCT CGAAGGGCTG GTGCTGCCTT 300 TCTCTGGAGC AGCCAGTGCA CAGGGTGTGC GCTTTGCCAC AGTGCAGTAC AGCGATGACC 360 CACGGACAGA GTTCGGCCTG GATGCACTTG GCTCTGGGGG TGATGTGATC CGCGCCATCC 420 GTGAGCTTAG CTACAAGGGG GGCAACACTC GCACAGGGGC TGCAATTCTC CATGTGGCTG 480 ACCATGTCTT CCTGCCCCAG CTGGCCCGAC CTGGTGTCCC CAAGGTCTGC ATCCTGATCA 540 CAGACGGGAA GTCCCAGGAC CTGGTGGACA CAGCTGCCCA AAGGCTGAAG GGGCAGGGGG 600 TCAAGCTATT TGCTGTGGGG ATCAAGAATG GTGACCCTGA GGAGCTGAAG CGAGTTGCCT 660 CACAGCCAAC CTCCGACTTC TTCTTCTTCG TCAATGACTT CAGCATCTTG AGGACACTAC 720 TGCCCCTCGT TTCCCGGAGA GTGTGCACGA CTGCTGGTGG CGTGCCTGTG ACCCGACCTC 780 CGGATGACTC GACCTCTGCT CCACGAGACC TGGTGCTGTC TGAGCCAAGC AGCCAATCCT 840 TGAGAGTACA GTGGACAGCG GCCAGTGGCC CTGTGACTGG CTACAAGGTC CAGTACACTC 900 CTCTGACGGG GCTGGGACAG CCACTGCCGA GTGAGCGGCA GGAGGTGAAC GTCCCAGCTG 960 GTGAGACCAG TGTGCGGCTG CGGGGTCTCC GGCCACTGAC CGAGTACCAA GTGACTGTGA 1020 TTGCCCTCTA CGCCAACAGC ATCGGGGAGG CTGTGAGCGG GACAGCTCGG ACCACTGCCC 1080 TAGAAGGGCC GGAACTGACC ATCCAGAATA CCACAGCCCA CAGCCTCCTG GTGGCCTGGC 1140 GGAGTGTGCC AGGTGCCACT GGCTACCGTG TGACATGGCG GGTCCTCAGT GGTGGGCCCA 1200 CACAGCAGCA GGAGCTGGGC CCTGGGCAGG GTTCAGTGTT GCTGCGTGAC TTGGAGCCTG 1260 GCACGGACTA TGAGGTGACC GTGAGCACCC TATTTGGCCG CAGTGTGGGG CCCGCCACTT 1320 CCCTGATGGC TCGCACTGAC GCTTCTGTTG AGCAGACCCT GCGCCCGGTC ATCCTGGGCC 1380 CCACATCCAT CCTCCTTTCC TGGAACTTGG TGCCTGAGGC CCGTGGCTAC CGGTTGGAAT 1440 GGCGGCGTGA GACTGGCTTG GAGCCACCGC AGAAGGTGGT ACTGCCCTCT GATGTGACCC 1500 GCTACCAGTT GGATGGGCTG CAGCCGGGCA CTGAGTACCG CCTCACACTC TACACTCTGC 1560 TGGAGGGCCA CGAGGTGGCC ACCCCTGCAA CCGTGGTTCC CACTGGACCA GAGCTGCCTG 1620 TGAGCCCTGT AACAGACCTG CAAGCCACCG AGCTGCCCGG GCAGCGGGTG CGAGTGTCCT 1680 GGAGCCCAGT CCCTGGTGCC ACCCAGTACC GCATCATTGT GCGCAGCACC CAGGGGGTTG 1740 AGCGGACCCT GGTGCTTCCT GGGAGTCAGA CAGCATTCGA CTTGGATGAC GTTCAGGCTG 1800 GGCTTAGCTA CACTGTGCGG GTGTCTGCTC GAGTGGGTCC CCGTGAGGGC AGTGCCAGTG 1860 TCCTCACTGT CCGCCGGGAG CCGGAAACTC CACTTGCTGT TCCAGGGCTG CGGGTTGTGG 1920 TGTCAGATGC AACGCGAGTG AGGGTGGCCT GGGGACCCGT CCCTGGAGCC AGTGGATTTC 1980 GGATTAGCTG GAGCACAGGC AGTGGTCCGG AGTCCAGCCA GACACTGCCC CCAGACTCTA 2040 CTGCCACAGA CATCACAGGG CTGCAGCCTG GAACCACCTA CCAGGTGGCT GTGTCGGTAC 2100 TGCGAGGCAG AGAGGAGGGC CCTGCTGCAG TCATCGTGGC TCGAACGGAC CCACTGGGCC 2160 CAGTGAGGAC GGTCCATGTG ACTCAGGCCA GCAGCTCATC TGTCACCATT ACCTGGACCA 2220 GGGTTCCTGG CGCCACAGGA TACAGGGTTT CCTGGCACTC AGCCCACGGC CCAGAGAAAT 2280 CCCAGTTGGT TTCTGGGGAG GCCACGGTGG CTGAGCTGGA TGGACTGGAG CCAGATACTG 2340

AGTATACGGT GCATGTGAGG GCCCATGTGG CTGGCGTGGA TGGGCCCCCT GCCTCTGTGG 2400

TTGTGAGGAC TGCCCCTGAG CCTGTGGGTC GTGTGTCGAG GCTGCAGATC CTCAATGCTT 2460

CCAGCGACGT TCTACGGATC ACCTGGGTAG GGGTCACTGG AGCCACAGCT TACAGACTGG 2520

CCTGGGGCCG GAGTGAAGGC GGCCCCATGA GGCACCAGAT ACTCCCAGGA AACACAGACT 2580

CTGCAGAGAT CCGGGGTCTC GAAGGTGGAG TCAGCTACTC AGTGCGAGTG ACTGCACTTG 2640

TCGGGGACCG CGAGGGCACA CCTGTCTCCA TTGTTGTCAC TACGCCGCCT GAGGCTCCGC 2700

CAGCCCTGGG GACGCTTCAC GTGGTGCAGC GCGGGGAGCA CTCGCTGAGG CTGCGCTGGG 2760

AGCCGGTGCC CAGAGCGCAG GGCTTCCTTC TGCACTGGCA ACCTGAGGGT GGCCAGGAAC 2820

AGTCCCGGGT CCTGGGGCCG GAGCTCAGCA GCTATCACCT GGACGGGCTG GAGCCAGCGA 2880

CACAGTACCG CGTGAGGCTG AGTGTCCTAG GGCCGGCTGG AGAAGGGCCC TCTGCAGAGG 2940

TGACTGCGCG CACTGAGTCA CCTCGTGTTC CAAGCATTGA ACTACGTGTG GTGGACACCT 3000

CGATCGACTC GGTGACTTTG GCCTGGACTC CAGTGTCCAG GGCATCCAGC TACATCCTAT 3060

CCTGGCGGCC ACTCAGAGGC CCTGGCCAGG AAGTGCCTGG GTCCCCGCAG ACACTTCCAG 3120

GGATCTCAAG CTCCCAGCGG GTGACAGGGC TAGAGCCTGG CGTCTCTTAC ATCTTCTCCC 3180

TGACGCCTGT CCTGGATGGT GTGCGGGGTC CTGAGGCATC TGTCACACAG ACGCCAGTGT 3240

GCCCCCGTGG CCTGGCGGAT GTGGTGTTCC TACCACATGC CACTCAAGAC AATGCTCACC 3300

GTGCGGAGGC TACGAGGAGG GTCCTGGAGC GTCTGGTGTT GGCACTTGGG CCTCTTGGGC 3360

CACAGGCAGT TCAGGTTGGC CTGCTGTCTT ACAGTCATCG GCCCTCCCCA CTGTTCCCAC 3420

TGAATGGCTC CCATGACCTT GGCATTATCT TGCAAAGGAT CCGTGACATG CCCTACATGG 3480

ACCCAAGTGG GAACAACCTG GGCACAGCCG TGGTCACAGC TCACAGATAC ATGTTGGCAC 3540

CAGATGCTCC TGGGCGCCGC CAGCACGTAC CAGGGGTGAT GGTTCTGCTA GTGGATGAAC 3600

CCTTGAGAGG TGACATATTC AGCCCCATCC GTGAGGCCCA GGCTTCTGGG CTTAATGTGG 3660

TGATGTTGGG AATGGCTGGA GCGGACCCAG AGCAGCTGCG TCGCTTGGCG CCGGGTATGG 3720

ACTCTGTCCA GACCTTCTTC GCCGTGGATG ATGGGCCAAG CCTGGACCAG GCAGTCAGTG 3780

GTCTGGCCAC AGCCCTGTGT CAGGCATCCT TCACTACTCA GCCCCGGCCA GAGCCCTGCC 3840

CAGTGTATTG TCCAAAGGGC CAGAAGGGGG AACCTGGAGA GATGGGCCTG AGAGGACAAG 3900

TTGGGCCTCC TGGCGACCCT GGCCTCCCGG GCAGGACCGG TGCTCCCGGC CCCCAGGGGC 3960

CCCCTGGAAG TGCCACTGCC AAGGGCGAGA GGGGCTTCCC TGGAGCAGAT GGGCGTCCAG 4020

GCAGCCCTGG CCGCGCCGGG AATCCTGGGA CCCCTGGAGC CCCTGGCCTA AAGGGCTCTC 4080

CAGGGTTGCC TGGCCCTCGT GGGGACCCGG GAGAGCGAGG ACCTCGAGGC CCAAAGGGGG 4140

AGCCGGGGGC TCCCGGACAA GTCATCGGAG GTGAAGGACC TGGGCTTCCT GGGCGGAAAG 4200

GGGACCCTGG ACCATCGGGC CCCCCTGGAC CTCGTGGACC ACTGGGGGAC CCAGGACCCC 4260

GTGGCCCCCC AGGGCTTCCT GGAACAGCCA TGAAGGGTGA CAAAGGCGAT CGTGGGGAGC 4320

GGGGTCCCCC TGGACCAGGT GAAGGTGGCA TTGCTCCTGG GGAGCCTGGG CTGCCGGGTC 4380

TTCCCGGAAG CCCTGGACCC CAAGGCCCCG TTGGCCCCCC TGGAAAGAAA GGAGAAAAAG 4440

GTGACTCTGA GGATGGAGCT CCAGGCCTCC CAGGACAACC TGGGTCTCCG GGTGAGCAGG 4500

GCCCACGGGG ACCTCCTGGA GCTATTGGCC CCAAAGGTGA CCGGGGCTTT CCAGGGCCCC 4560

TGGGTGAGGC TGGAGAGAAG GGCGAACGTG GACCCCCAGG CCCAGCGGGA TCCCGGGGGC 4620

TGCCAGGGGT TGCTGGACGT CCTGGAGCCA AGGGTCCTGA AGGGCCACCA GGACCCACTG 4680

GCCGCCAAGG AGAGAAGGGG GAGCCTGGTC GCCCTGGGGA CCCTGCAGTG GTGGGACCTG 4740

CTGTTGCTGG ACCCAAAGGA GAAAAGGGAG ATGTGGGGCC CGCTGGGCCC AGAGGAGCTA 4800

CCGGAGTCCA AGGGGAACGG GGCCCACCCG GCTTGGTTCT TCCTGGAGAC CCTGGCCCCA 4860

AGGGAGACCC TGGAGACCGG GGTCCCATTG GCCTTACTGG CAGAGCAGGA CCCCCAGGTG 4920

ACTCAGGGCC TCCTGGAGAG AAGGGAGACC CTGGGCGGCC TGGCCCCCCA GGACCTGTTG 4980

GCCCCCGAGG ACGAGATGGT GAAGTTGGAG AGAAAGGTGA CGAGGGTCCT CCGGGTGACC 5040

CGGGTTTGCC TGGAAAAGCA GGCGAGCGTG GCCTTCGGGG GGCACCTGGA GTTCGGGGGC 5100

CTGTGGGTGA AAAGGGAGAC CAGGGAGATC CTGGAGAGGA TGGACGAAAT GGCAGCCCTG 5160

GATCATCTGG ACCCAAGGGT GACCGTGGGG AGCCGGGTCC CCCAGGACCC CCGGGACGGC 5220

TGGTAGACAC AGGACCTGGA GCCAGAGAGA AGGGAGAGCC TGGGGACCGC GGACAAGAGG 5280

GTCCTCGAGG GCCCAAGGGT GATCCTGGCC TCCCTGGAGC CCCTGGGGAA AGGGGCATTG 5340

AAGGGTTTCG GGGACCCCCA GGCCCACAGG GGGACCCAGG TGTCCGAGGC CCAGCAGGAG 5400

AAAAGGGTGA CCGGGGTCCC CCTGGGCTGG ATGGCCGGAG CGGACTGGAT GGGAAACCAG 5460

GAGCCGCTGG GCCCTCTGGG CCGAATGGTG CTGCAGGCAA AGCTGGGGAC CCAGGGAGAG 5520

ACGGGCTTCC AGGCCTCCGT GGAGAACAAG GCCTCCCTGG CCCCTCTGGT CCCCCTGGAT 5580

TACCGGGAAA GCCAGGCGAG GATGGGAAAC CTGGCCTGAA TGGAAAAAAC GGAGAACCTG 5640

GGGACCCTGG AGAAGACGGG AGGAAGGGAG AGAAAGGAGA TTCAGGCGCC TCTGGGAGAG 5700

AAGGTCGTGA TGGCCCCAAG GGTGAGCGTG GAGCTCCTGG TATCCTTGGA CCCCAGGGGC 5760

CTCCAGGCCT CCCAGGGCCA GTGGGCCCTC CTGGCCAGGG TTTTCCTGGT GTCCCAGGAG 5820

GCACGGGCCC CAAGGGTGAC CGTGGGGAGA CTGGATCCAA AGGGGAGCAG GGCCTCCCTG 5880

GAGAGCGTGG CCTGCGAGGA GAGCCTGGAA GTGTGCCGAA TGTGGATCGG TTGCTGGAAA 5940

CTGCTGGCAT CAAGGCATCT GCCCTGCGGG AGATCGTGGA GACCTGGGAT GAGAGCTCTG 6000

GTAGCTTCCT GCCTGTGCCC GAACGGCGTC GAGGCCCCAA GGGGGACTCA GGCGAACAGG 6060

GCCCCCCAGG CAAGGAGGGC CCCATCGGCT TTCCTGGAGA ACGCGGGCTG AAGGGCGACC 6120

GTGGAGACCC TGGCCCTCAG GGGCCACCTG GTCTGGCCCT TGGGGAGAGG GGCCCCCCCG 6180

GGCCTTCCGG CCTTGCCGGG GAGCCTGGAA AGCCTGGTAT TCCCGGGCTC CCAGGCAGGG 6240

CTGGGGGTGT GGGAGAGGCA GGAAGGCCAG GAGAGAGGGG AGAACGGGGA GAGAAAGGAG 6300

AACGTGGAGA ACAGGGCAGA GATGGCCCTC CTGGACTCCC TGGAACCCCT GGGCCCCCCG 6360

GACCCCCTGG CCCCAAGGTG TCTGTGGATG AGCCAGGTCC TGGACTCTCT GGAGAACAGG 6420

GACCCCCTGG ACTCAAGGGT GCTAAGGGGG AGCCGGGCAG CAATGGTGAC CAAGGTCCCA 6480

AAGGAGACAG GGGTGTGCCA GGCATCAAAG GAGACCGGGG AGAGCCTGGA CCGAGGGGTC 6540

AGGACGGCAA CCCGGGTCTA CCAGGAGAGC GTGGTATGGC TGGGCCTGAA GGGAAGCCGG 6600

GTCTGCAGGG TCCAAGAGGC CCCCCTGGCC CAGTGGGTGG TCATGGAGAC CCTGGACCAC 6660

CTGGTGCCCC GGGTCTTGCT GGCCCTGCAG GACCCCAAGG ACCTTCTGGC CTGAAGGGGG 6720

AGCCTGGAGA GACAGGACCT CCAGGACGGG GCCTGACTGG ACCTACTGGA GCTGTGGGAC 6780

TTCCTGGACC CCCCGGCCCT TCAGGCCTTG TGGGTCCACA GGGGTCTCCA GGTTTGCCTG 6840

GACAAGTGGG GGAGACAGGG AAGCCGGGAG CCCCAGGTCG AGATGGTGCC AGTGGAAAAG 6900

ATGGAGACAG AGGGAGCCCT GGTGTGCCAG GGTCACCAGG TCTGCCTGGC CCTGTCGGAC 6960

CTAAAGGAGA ACCTGGCCCC ACGGGGGCCC CTGGACAGGC TGTGGTCGGG CTCCCTGGAG 7020

CAAAGGGAGA GAAGGGAGCC CCTGGAGGCC TTGCTGGAGA CCTGGTGGGT GAGCCGGGAG 7080

CCAAAGGTGA CCGAGGACTG CCAGGGCCGC GAGGCGAGAA GGGTGAAGCT GGCCGTGCAG 7140

GGGAGCCCGG AGACCCTGGG GAAGATGGTC AGAAAGGGGC TCCAGGACCC AAAGGTTTCA 7200

AGGGTGACCC AGGAGTCGGG GTCCCGGGCT CCCCTGGGCC TCCTGGCCCT CCAGGTGTGA 7260

AGGGAGATCT GGGCCTCCCT GGCCTGCCCG GTGCTCCTGG TGTTGTTGGG TTCCCGGGTC 7320

AGACAGGCCC TCGAGGAGAG ATGGGTCAGC CAGGCCCTAG TGGAGAGCGG GGTCTGGCAG 7380

GCCCCCCAGG GAGAGAAGGA ATCCCAGGAC CCCTGGGGCC ACCTGGACCA CCGGGGTCAG 7440

TGGGACCACC TGGGGCCTCT GGACTCAAAG GAGACAAGGG AGACCCTGGA GTAGGGCTGC 7500 CTGGGCCCCG AGGCGAGCGT GGGGAGCCAG GCATCCGGGG TGAAGATGGC CGCCCCGGCC 7560

AGGAGGGACC CCGAGGACTC ACGGGGCCCC CTGGCAGCAG GGGAGAGCGT GGGGAGAAGG 7620

GTGATGTTGG GAGTGCAGGA CTAAAGGGTG ACAAGGGAGA CTCAGCTGTG ATCCTGGGGC 7680

CTCCAGGCCC ACGGGGTGCC AAGGGGGACA TGGGTGAACG AGGGCCTCGG GGCTTGGATG 7740

GTGACAAAGG ACCTCGGGGA GACAATGGGG ACCCTGGTGA CAAGGGCAGC AAGGGAGAGC 7800

CTGGTGACAA GGGCTCAGCC GGGTTGCCAG GACTGCGTGG ACTCCTGGGA CCCCAGGGTC 7860

AACCTGGTGC AGCAGGGATC CCTGGTGACC CGGGATCCCC AGGAAAGGAT GGAGTGCCTG 7920

GTATCCGAGG AGAAAAAGGA GATGTTGGCT TCATGGGTCC CCGGGGCCTC AAGGGTGAAC 7980

GGGGAGTGAA GGGAGCCTGT GGCCTTGATG GAGAGAAGGG AGACAAGGGA GAAGCTGGTC 8040

CCCCAGGCCG CCCCGGGCTG GCAGGACACA AAGGAGAGAT GGGGGAGCCT GGTGTGCCGG 8100

GCCAGTCGGG GGCCCCTGGC AAGGAGGGCC TGATCGGTCC CAAGGGTGAC CGAGGCTTTG 8160

ACGGGCAGCC AGGCCCCAAG GGTGACCAGG GCGAGAAAGG GGAGCGGGGA ACCCCAGGAA 8220

TTGGOGGCTT CCCAGGCCCC AGTGGAAATG ATGGCTCTGC TGGTCCCCCA GGGCCACCTG 8280

GCAGTGTTGG TCCCAGAGGC CCCGAAGGAC TTCAGGGCCA GAAGGGTGAG CGAGGTCCCC 8340

CCGGAGAGAG AGTGGTGGGG GCTCCTGGGG TCCCTGGAGC TCCTGGCGAG AGAGGGGAGC 8400

AGGGGCGGCC AGGGCCTGCC GGTCCTCGAG GCGAGAAGGG AGAAGCTGCA CTGACGGAGG 8460

ATGACATCCG GGGCTTTGTG CGCCAAGAGA TGAGTCAGCA CTGTGCCTGC CAGGGCCAGT 8520

TCATCGCATC TGGATCACGA CCCCTCCCTA GTTATGCTGC AGACACTGCC GGCTCCCAGC 8580

TCCATGCTGT GCCTGTGCTC CGCGTCTCTC ATGCAGAGGA GGAAGAGCGG GTACCCCCTG 8640

AGGATGATGA GTACTCTGAA TACTCCGAGT ATTCTGTGGA GGAGTACCAG GACCCTGAAG 8700

CTCCTTGGGA TAGTGATGAC CCCTGTTCCC TGCCACTGGA TGAGGGCTCC TGCACTGCCT 8760

ACACCCTGCG CTGGTACCAT CGGGCTGTGA CAGGCAGCAC AGAGGCCTGT CACCCTTTTG 8820

TCTATGGTGG CTGTGGAGGG AATGCCAACC GTTTTGGGAC CCGTGAGGCC TGCGAGCGCC 8880

GCTGCCCACC CCGGGTGGTC CAGAGCCAGG GGACAGGTAC TGCCCAGGAC TGAGGCCCAG 8940

ATAATGAGCT GAGATTCAGC ATCCCCTGGA GGAGTCGGGG TCTCAGCAGA ACCCCACTGT 9000

CCCTCCCCTT GGTGCTAGAG GCTTGTGTGC ACGTGAGCGT GCGAGTGCAC GTCCGTTATT 9060

TCAGTGACTT GGTCCCGTGG GTCTAGCCTT CCCCCCTGTG GACAAACCCC CATTGTGGCT 9120

CCTGCCACCC TGGCAGATGA CTCACTGTGG GGGGGTGGCT GTGGGCAGTG AGCGGATGTG 9180

ACTGGCGTCT GACCCGCCCC TTGACCCAAG CCTGTGATGA CATGGTGCTG ATTCTGGGGG 9240 GCATTAAAGC TGCTGTTTTA AAAGGCAAAA AA

Seq ID NO: 63 Protein sequence: Protein Accession #: NP 000085.1

1 11 21 31 41 51

I I I I I I

MTLRLLVAAL CAGILAEAPR VRAQHRERVT CTRLYAADIV FLLDGSSSIG RSNFREVRSF 60

LEGLVLPFSG AASAQGVRFA TVQYSDDPRT EFGLDALGSG GDVIRAIREL SYKGGNTRTG 120

AAILHVADHV FLPQLARPGV PKVCILITDG KSQDLVDTAA QRLKGQGVKL FAVGIKNADP 180

EELKRVASQP TSDFFFFVND FSILRTLLPL VSRRVCTTAG GVPVTRPPDD STSAPRDLVL 240

SEPSSQSLRV QWTAASGPVT GYKVQYTPLT GLGQPLPSER QEVNVPAGET SVRLRGLRPL 300

TEYQVTVIAL YANSIGEAVS GTARTTALEG PELTIQNTTA HSLLVAHRSV PGATGYRVTW 360

RVLSGGPTQQ QELGPGQGSV LLRDLEPGTD^' YEVTVSTLFG RSVGPATSLM ARTDASVEQT 420

LRPVILGPTS ILLSWNLVPE ARGYRLEWRR ETGLEPPQKV VLPSDVTRYQ LDGLQPGTEY 480

RLTLYTLLEG HEVATPATW PTGPELPVSP VTDLQATELP GQRVRVSWSP VPGATQYRII 540

VRSTQGVERT LVLPGSQTAF DLDDVQAGLS YTVRVSARVG PREGSASVLT VRREPETPLA 600

VPGLRVWSD ATRVRVAWGP VPGASGFRIS WSTGSGPESS QTLPPDSTAT DITGLQPGTT 660

YQVAVSVLRG REEGPAAVIV ARTDPLGPVR TVHVTQASSS SVTITWTRVP GATGYRVSWH 720

SAHGPEKSQL VSGEATVAEL DGLEPDTEYT VHVRAHVAGV DGPPASWVR TAPEPVGRVS 780

RLQILNASSD VLRITWVGVT GATAYRLAWG RSEGGPMRHQ ILPGNTDSAE IRGLEGGVSY 840

SVRVTALVGD REGTPVSIW TTPPEAPPAL GTLHWQRGE HSLRLR EPV PRAQGFLLH 900

QPEGGQEQSR VLGPELSSYH LDGLEPATQY RVRLSVLGPA GEGPSAEVTA RTESPRVPSI 960

ELRWDTSID SVTLAWTPVS RASSYILSWR PLRGPGQEVP GSPQTLPGIS SSQRVTGLEP 1020

GVSYIFSLTP VLDGVRGPEA SVTQTPVCPR GLADWFLPH ATQDNAHRAE ATRRVLERLV 1080 LALGPLGPQA VQVGLLSYSH RPSPLFPLNG SHDLGIILQR IRDMPYMDPS GNNLGTAWT 1140

AHRYMLAPDA PGRRQHVPGV MVLLVDEPLR GDIFSPIREA QASGLNWML GMAGADPEQL 1200

RRLAPGMDSV QTFFAVDDGP SLDQAVSGLA TALCQASFTT QPRPEPCPVY CPKGQKGEPG 1260

EMGLRGQVGP PGDPGLPGRT GAPGPQGPPG SATAKGERGF PGADGRPGSP GRAGNPGTPG 1320

APGLKGSPGL PGPRGDPGER GPRGPKGEPG APGQVIGGEG PGLPGRKGDP GPSGPPGPRG 1380

PLGDPGPRGP PGLPGTAMKG DKGDRGERGP PGPGEGGIAP GEPGLPGLPG SPGPQGPVGP 1440

PGKKGEKGDS EDGAPGLPGQ PGSPGEQGPR GPPGAIGPKG DRGFPGPLGE AGEKGERGPP 1500

GPAGSRGLPG VAGRPGAKGP EGPPGPTGRQ GEKGEPGRPG DPAWGPAVA GPKGEKGDVG 1560

PAGPRGATGV QGERGPPGLV LPGDPGPKGD PGDRGPIGLT GRAGPPGDSG PPGEKGDPGR 1620

PGPPGPVGPR GRDGEVGEKG DEGPPGDPGL PGKAGERGLR GAPGVRGPVG EKGDQGDPGE 1680

DGRNGSPGSS GPKGDRGEPG PPGPPGRLVD TGPGAREKGE PGDRGQEGPR GPKGDPGLPG 1740

APGERGIEGF RGPPGPQGDP GVRGPAGEKG DRGPPGLDGR SGLDGKPGAA GPSGPNGAAG 1800

KAGDPGRDGL PGLRGEQGLP GPSGPPGLPG KPGEDGKPGL NGKNGEPGDP GEDGRKGEKG 1860

DSGASGREGR DGPKGERGAP GILGPQGPPG LPGPVGPPGQ GFPGVPGGTG PKGDRGETGS 1920

KGEQGLPGER GLRGEPGSVP NVDRLLETAG IKASALREIV ETWDESSGSF LPVPERRRGP 1980 KGDSGEQGPP GKEGPIGFPG ERGLKGDRGD PGPQGPPGLA LGERGPPGPS GLAGEPGKPG 2040

IPGLPGRAGG VGEAGRPGER GERGEKGERG EQGRDGPPGL PGTPGPPGPP GPKVSVDEPG 2100

PGLSGEQGPP GLKGAKGEPG SNGDQGPKGD RGVPGIKGDR GEPGPRGQDG NPGLPGERGM 2160

AGPEGKPGLQ GPRGPPGPVG GHGDPGPPGA PGLAGPAGPQ GPSGLKGEPG ETGPPGRGLT 2220

GPTGAVGLPG PPGPSGLVGP QGSPGLPGQV GETGKPGAPG RDGASGKDGD RGSPGVPGSP 2280

GLPGPVGPKG EPGPTGAPGQ AWGLPGAKG EKGAPGGLAG DLVGEPGAKG DRGLPGPRGE 2340

KGEAGRAGEP GDPGEDGQKG APGPKGFKGD PGVGVPGSPG PPGPPGVKGD LGLPGLPGAP 2400

GWGFPGQTG PRGEMGQPGP SGERGLAGPP GREGIPGPLG PPGPPGSVGP PGASGLKGDK 2460

GDPGVGLPGP RGERGEPGIR GEDGRPGQEG PRGLTGPPGS RGERGEKGDV GSAGLKGDKG 2520

DSAVILGPPG PRGAKGDMGE RGPRGLDGDK GPRGDNGDPG DKGSKGEPGD KGSAGLPGLR 2580

GLLGPQGQPG AAGIPGDPGS PGKDGVPGIR GEKGDVGFMG PRGLKGERGV KGACGLDGEK 2640

GDKGEAGPPG RPGLAGHKGE MGEPGVPGQS GAPGKEGLIG PKGDRGFDGQ PGPKGDQGEK 2700

GERGTPGIGG FPGPSGNDGS AGPPGPPGSV GPRGPEGLQG QKGERGPPGE RWGAPGVPG 2760

APGERGEQGR PGPAGPRGEK GEAALTEDDI RGFVRQEMSQ HCACQGQFIA SGSRPLPSYA 2820

ADTAGSQLHA VPVLRVSHAE EEERVPPEDD EYSEYSEYSV EEYQDPEAPW DSDDPCSLPL 2880

DEGSCTAYTL RWYHRAVTGS TEACHPFVYG GCGGNANRFβ TREACERRCP PRWQSQGTG 2940 TAQD Seq ID NO: 64 DNA sequence

Nucleic Acid Accession #: NM_006945

Coding sequence: 1-219

1 11 21 31 41 51

A ITGTCTTATC AIACAGCAGCA GITGCAAGCAG CICCTGCCAGC CIACCTCCTGT GITGCCCCACG 60

CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 120

TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAGAAAT ATCCTCCTGT GACACCTTCC 180 CCACCCTGCC AGCCAAAGTA TCCACCGAAG AGCAAGTAA

Seq ID NO : 65 Protein sequence : Protein Accession # : NP_008876

1 11 21 31 41 51

1 I ! I I I

MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC QQKYPPVTPS 60 PPCQPKYPPK SK Seq ID NO: 66 DNA sequence

Nucleic Acid Accession # : NM_005629.1 Coding sequence: 639-2546

1 11 21 31 41 51 I i i i i i

TAGTCGGAGC GAGGTGGCGA GTCGCTGAGC CCGCCGCGGC CCCGAGAGCG GCTGCAGCCG 60

CCGCCGCCGG GAAGGAGAGG GCGAGGCGCG CCCGAGCCGC CGCCGCCGCC GCCACCGCCG 120

CCGCCGCCAC CACCGCCACC GGAGTCGCGG GCCAGCCGGG CAGCCTCCGC GGGCCCCGGC 180

CGGGGCGGGG GGCGCGGGCC ACAGGCCCCT GCTCCGGCCG TCGTTTGCAG ACCGCGGGCG 240

CCGATGTCGC CCGCGCCCCG TTAGGATGAG TCTCGGGTCG GGCGAGGAGC CGCCGCAGCC 300

GCCGCCGCCC GAGCCGCGGG CAGGAGCCTC GGGAGCCGCC GCCGCCGCCG CCGCCGCCCG 360

GCCGGGCCCC GACGCCGCCC GCGCGCCCCC GGGCCCCCGA CACACATGAG ATTCTTCAGG 420

CTCACTTTCA AGTGCTTCGT GGACTGCTTC TGACTGCGCC GCCCGCGCCC CGCACCCCGC 480

CGTCCGCCCG CCGCCCCGTC CCCCGGCCCG GCCGCCCCCC GGCCCCCGGC CGGCCCGCGC 540

CCTCGGGGCC CTCCCCGGTG CCGCCGGTGC CCCCCGCCTG ACCGCCGCCC CCCGTGAGGC 600

GCCGCGACCC CGGCCCGGCC GTGCGGCCCG CCGGGGCCAT GGCGAAGAAG AGCGCCGAGA 660

ACGGCATCTA TAGCGTGTCC GGCGACGAGA AGAAGGGCCC CCTCATCGCG CCCGGGCCCG 720

ACGGGGCCCC GGCCAAGGGC GACGGCCCCG TGGGCCTGGG GACACCCGGC GGCCGCCTGG 780

CCGTGCCGCC GCGCGAGACC TGGACGCGCC AGATGGACTT CATCATGTCG TGCGTGGGCT 840

TCGCCGTGGG CTTGGGCAAC GTGTGGCGCT TCCCCTACCT GTGCTACAAG AACGGCGGAG 900

GTGTGTTCCT TATTCCCTAC GTCCTGATCG CCCTGGTTGG AGGAATCCCC ATTTTCTTCT 960

TAGAGATCTC GCTGGGCCAG TTCATGAAGG CCGGCAGCAT CAATGTCTGG AACATCTGTC 1020

CCCTGTTCAA AGGCCTGGGC TACGCCTCCA TGGTGATCGT CTTCTACTGC AACACCTACT 1080

ACATCATGGT GCTGGCCTGG GGCTTCTATT ACCTGGTCAA GTCCTTTACC ACCACGCTGC 1140

CCTGGGCCAC ATGTGGCCAC ACCTGGAACA CTCCCGACTG CGTGGAGATC TTCCGCCATG 1200

AAGACTGTGC CAATGCCAGC CTGGCCAACC TCACCTGTGA CCAGCTTGCT GACCGCCGGT 1260

CCCCTGTCAT CGAGTTCTGG GAGAACAAAG TCTTGAGGCT GTCTGGGGGA CTGGAGGTGC 1320

CAGGGGCCCT CAACTGGGAG GTGACCCTTT GTCTGCTGGC CTGCTGGGTG CTGGTCTACT 1380

TCTGTGTCTG GAAGGGGGTC AAATCCACGG GAAAGATCGT GTACTTCACT GCTACATTCC 1440

CCTACGTGGT CCTGGTCGTG CTGCTGGTGC GTGGAGTGCT GCTGCCTGGC GCCCTGGATG 1500

GCATCATTTA CTATCTCAAG CCTGACTGGT CAAAGCTGGG GTCCCCTCAG GTGTGGATAG 1560

ATGCGGGGAC CCAGATTTTC TTTTCTTACG CCATTGGCCT GGGGGCCCTC ACAGCCCTGG 1620

GCAGCTACAA CCGCTTCAAC AACAACTGCT ACAAGGACGC CATCATCCTG GCTCTCATCA 1680

ACAGTGGGAC CAGCTTCTTT GCTGGCTTCG TGGTCTTCTC CATCCTGGGC TTCATGGCTG 1740

CAGAGCAGGG CGTGCACATC TCCAAGGTGG CAGAGTCAGG GCCGGGCCTG GCCTTCATCG 1800

CCTACCCGCG GGCTGTCACG CTGATGCCAG TGGCCCCACT CTGGGCTGCC CTGTTCTTCT 1860

TCATGCTGTT GCTGCTTGGT CTCGACAGCC 'AGTTTGTAGG TGTGGAGGGC TTCATCACCG 1920

GCCTCCTCGA CCTCCTCCCG GCCTCCTACT ACTTCCGTTT CCAAAGGGAG ATCTCTGTGG 1980

CCCTCTGTTG TGCCCTCTGC TTTGTCATCG ATCTCTCCAT GGTGACTGAT GGCGGGATGT 2040

ACGTCTTCCA GCTGTTTGAC TACTACTCGG CCAGCGGCAC CACCCTGCTC TGGCAGGCCT 2100

TTTGGGAGTG CGTGGTGGTG GCCTGGGTGT ACGGAGCTGA CCGCTTCATG GACGACATTG 2160

CCTGTATGAT CGGGTACCGA CCTTGCCCCT GGATGAAATG GTGCTGGTCC TTCTTCACCC 2220

CGCTGGTCTG CATGGGCATC TTCATCTTCA ACGTTGTGTA CTACGAGCCG CTGGTCTACA 2280

ACAACACCTA CGTGTACCCG TGGTGGGGTG AGGCCATGGG CTGGGCCTTC GCCCTGTCCT 2340

CCATGCTGTG CGTGCCGCTG CACCTCCTGG GCTGCCTCCT CAGGGCCAAG GGCACCATGG 2400

CTGAGCGCTG GCAGCACCTG ACCCAGCCCA TCTGGGGCCT CCACCACTTG GAGTACCGAG 2460

CTCAGGACGC AGATGTCAGG GGCCTGACCA CCCTGACCCC AGTGTCCGAG AGCAGCAAGG 2520

TCGTCGTGGT GGAGAGTGTC ATGTGACAAC TCAGCTCACA TCACCAGCTC ACCTCTGGTA 2580

GCCATAGCAG CCCCTGCTTC AGCCCCACCG CACCCCTCCA GGGGGCCTGC CTTTCCCTGA 2640

CACTTTTGGG GTCTGCCTGG GGGAGGAGGG GAGAAAGCAC CATGAGTGCT CACTAAAACA 2700

ACTTTTTCCA TTTTTAATAA AACGCCAAAA ATATCACAAC CCACCAAAAA TAGATGCCTC 2760

TCCCCCTCCA GCCCTAGCCG AGCTGGTCCT AGGCCCCGCC TAGTGCCCCA CCCCCACCCA 2820

CAGTGCTGCA CTCCTCCTGC CCCTGCCACG CCCACCCCCT GCCCACCTCT CCAGGCTCTG 2880

CTCTGCAGCA CACCCGTGGG TGACCCCTCA CCCCAGAAGC AGCAGTGGCA GCTTGGGAAA 2940

TGTGAGGAAG GGAAGGAGGG AGAGACGGGA GGGAGGAGAG AGAGGAGAAG GGAGGCAGGG 3000

GAGGGGCAGC AGAACCAAGG CAAATATTTC AGCTGGGCTA TACCCCTCTC CCCATCCCTβ 3060

TTATAGAAGC TTAGAGAGCC AGCCAGCAAT GGAACCTTCT GGTTCCTGCG CCAATCGCCA 3120

CCAGTATCAA TTGTGTGAGC TTGGGTGCGA GTGCACGCGT GCGTGAGTAC GGAGAGTATA 3180

TATAGATCTC TATCTCTTAG CAAAGGTGAA TGCCAGATGT AAATGGCGCC TCTGGGCAAA 3240

GGAGGCTTGT ATTTTGCACA TTTTATAAAA ACTTGAGAGA ATGAGATTTC TGCTTGTATA 3300

TTTCTAAAAA GAGGAAGGAG CCCAAACCAT CCTCTCCTTA CCACTCCCAT CCCTGTGAGC 3360

CCTACCTTAC CCCTCTGCCC CTAGCCAAGG AGTGTGAATT TATAGATCTA ACTTTCATAG 3420

GCAAAACAAA AGCTTCGAGC TGTTGCGTGT GTGAGTCTGT TGTGTGGATG TGCGTGTGTG 3480

GTCCCCAGCC CCAGACTGGA TTGGAAAAGT GCATGGTGGG GGCCTCGGGG CTGTCCCCAC 3540

GCTGTCCCTT TGCCACAAGT CTGTGGGGCA AGAGGCTGCA ATATTCCGTC CTGGGTGTCT 3600

GGGCTGCTAA CCTGGCCTGC TCAGGCTTCC CACCCTGTGC GGGGCACACC CCCAGGAAGG 3660

GACCCTGGAC ACGGCTCCCA CGTCCAGGCT TAAGGTGGAT GCACTTCCCG CACCTCCAGT 3720 CTTCTGTGTA GCAGCTTTAA CCCACGTTTG TCTGTCACGT CCAGTCCCGA GACGGCTGAG 3780

TGACCCCAAG AAAGGCTTCC CCGACACCCA GACAGAGGCT GCAGGGCTGG GGCTGGGTGA 3840

GGGTGGCGGG CCTGCGGGGA CATTCTACTG TGCTAAAAAG CCACTGCAGA CATAGCAATA 3900 AAAACATGTC ATTTTCC

Seq ID NO: 67 Protein sequence: Protein Accession #: NP_005620.1

. _Λ 1 11 21 31 41 51

10 I I I I I I

MAKKSAENGI YSVSGDEKKG PLIAPGPDGA PAKGDGPVGL GTPGGRLAVP PRETWTRQMD 60

FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS 120

INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD 180

CVEIFRHEDC ANASLANLTC DQLADRRSPV IEFWENKVLR LSGGLEVPGA LNWEVTLCLL 240

15 ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLWLLVRGV LLPGALDGII YYLKPDWSKL 300

GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFWF 360

SILGFMAAEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV 420

GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVTDGGMYVF QLFDYYSASG 480

TTLLWQAFWE CVWAWVYGA DRFMDDIACM IGYRPCP MK CWSFFTPLV CMGIFIFNW 540

20 YYEPLVYNNT YVYPW GEAM GWAFALSSML CVPLHLLGCL LRAKGTMAER QHLTQPIWG 600

LHHLEYRAQD ADVRGLTTLT PVSESSK W VESVM

Seq ID NO: 68 DNA sequence 25 Nucleic Acid Accession #: NM_021953.1 Coding sequence: 178-2469

1 11 21 31 41 51

,_Λ I 1 I I I I

JV GGCACGAGGG GGACCCGGCC GGTCCGGCGC GAGCCCCCGT CCGGGGCCCT GGCTCGGCCC 60 ,

CCAGGTTGGA GGAGCCCGGA GCCCGCCTTC GGAGCTACGG CCTAACGGCG GCGGCGACTG 120

CAGTCTGGAG GGTCCACACT TGTGATTCTC AATGGAGAGT GAAAACGCAG ATTCATAATG 180

AAAGCTAGCC CCCGTCGGCC ACTGATTCTC AAAAGACGGA GGCTGCCCCT TCCTGTTCAA 240

AATGCCCCAA GTGAAACATC AGAGGAGGAA CCTAAGAGAT CCCCTGCCCA ACAGGAGTCT 300

35 AATCAAGCAG AGGCCTCCAA GGAAGTGGCG GAGTCCAACT CTTGCAAGTT TCCAGCTGGG 360

ATCAAGATTA TTAACCACCC CACCATGCCC AACACGCAAG TAGTGGCCAT CCCCAACAAT 420

GCTAATATTC ACAGCATCAT CACAGCACTG ACTGCCAAGG GAAAAGAGAG TGGCAGTAGT 480

GGGCCCAACA AATTCATCCT CATCAGCTGT GGGGGAGCCC CAACTCAGCC TCCAGGACTC 540

. CGGCCTCAAA CCCAAACCAG CTATGATGCC AAAAGGACAG AAGTGACCCT GGAGACCTTG 600

40 GGACCAAAAC CTGCAGCTAG GGATGTGAAT CTTCCTAGAC CACCTGGAGC CCTTTGCGAG 660

CAGAAACGGG AGACCTGTGC AGATGGTGAG GCAGCAGGCT GCACTATCAA CAATAGCCTA 720

TCCAACATCC AGTGGCTTCG AAAGATGAGT TCTGATGGAC TGGGCTCCCG CAGCATCAAG 780

CAAGAGATGG AGGAAAAGGA GAATTGTCAC CTGGAGCAGC GACAGGTTAA GGTTGAGGAG 840

CCTTCGAGAC CATCAGCGTC CTGGCAGAAC TCTGTGTCTG AGCGGCCACC CTACTCTTAC 900

45 ATGGCCATGA TACAATTCGC CATCAACAGC AGTGAGAGGA AGCGCATGAC TTTGAAAGAC 960

ATCTATACGT GGATTGAGGA CCACTTTCCC TACTTTAAGC ACATTGCCAA GCCAGGCTGG 1020

AAGAACTCCA TCCGCCACAA CCTTTCCCTG CACGACATGT TTGTCCGGGA GACGTCTGCC 1080

AATGGCAAGG TCTCCTTCTG GACCATTCAC CCCAGTGCCA ACCGCTACTT GACATTGGAC 1140

CAGGTGTTTA AGCCACTGGA CCCAGGGTCT CCACAATTGC CCGAGCACTT GGAATCACAG 1200

50 CAGAAACGAC CGAATCCAGA GCTCCGCCGG AACATGACCA TCAAAACCGA ACTCCCCCTG 1260

GGCGCACGGC GGAAGATGAA GCCACTGCTA CCACGGGTCA GCTCATACCT GGTACCTATC 1320

CAGTTCCCGG TGAACCAGTC ACTGGTGTTG CAGCCCTCGG TGAAGGTGCC ATTGCCCCTG 1380

GCGGCTTCCC TCATGAGCTC AGAGCTTGCC CGCCATAGCA AGCGAGTCCG CATTGCCCCC 1440

AAGGTGCTGC TAGCTGAGGA GGGGATAGCT CCTCTTTCTT CTGCAGGACC AGGGAAAGAG 1500

55 GAGAAACTCC TGTTTGGAGA AGGGTTTTCT CCTTTGCTTC CAGTTCAGAC TATCAAGGAG 1560

GAAGAAATCC AGCCTGGGGA GGAAATGCCA CACTTAGCGA GACCCATCAA AGTGGAGAGC 1620

CCTCCCTTGG AAGAGTGGCC CTCCCCGGCC CCATCTTTCA AAGAGGAATC ATCTCACTCC 1680

TGGGAGGATT CGTCCCAATC TCCCACCCCA AGACCCAAGA AGTCCTACAG TGGGCTTAGG 1740

TCCCCAACCC GGTGTGTCTC GGAAATGCTT GTGATTCAAC ACAGGGAGAG GAGGGAGAGG 1800

60 AGCCGGTCTC GGAGGAAACA GCATCTACTG CCTCCCTGTG TGGATGAGCC GGAGCTGCTC 1860

TTCTCAGAGG GGCCCAGTAC TTCCCGCTGG GCCGCAGAGC TCCCGTTCCC AGCAGACTCC 1920

TCTGACCCTG CCTCCCAGCT CAGCTACTCC CAGGAAGTGG GAGGACCTTT TAAGACACCC 1980

ATTAAGGAAA CGCTGCCCAT CTCCTCCACC CCGAGCAAAT CTGTCCTCCC CAGAACCCCT 2040

GAATCCTGGA GGCTCACGCC CCCAGCCAAA GTAGGGGGAC TGGATTTCAG CCCAGTACAA 2100

65 ACCTCCCAGG GTGCCTCTGA CCCCTTGCCT GACCCCCTGG GGCTGATGGA TCTCAGCACC 2160

ACTCCCTTGC AAAGTGCTCC CCCCCTTGAA TCACCGCAAA GGCTCCTCAG TTCAGAACCC 2220

TTAGACCTCA TCTCCGTCCC CTTTGGCAAC TCTTCTCCCT CAGATATAGA CGTCCCCAAG 2280

CCAGGCTCCC CGGAGCCACA GGTTTCTGGC CTTGCAGCCA ATCGTTCTCT GACAGAAGGC 2340

CTGGTCCTGβ ACACAATGAA TGACAGCCTC AGCAAGATCC TGCTGGACAT CAGCTTTCCT 2400

70 GGCCTGGACG AGGACCCACT GGGCCCTGAC AACATCAACT GGTCCCAGTT TATTCCTGAG 2460

CTACAGTAGA GCCCTGCCCT TGCCCCTGTG CTCAAGCTGT CCACCATCCC GGGCACTCCA 2520

AGGCTCAGTG CACCCCAAGC CTCTGAGTGA GGACAGCAGG CAGGGACTGT TCTGCTCCTC 2580

ATAGCTCCCT GCTGCCTGAT TATGCAAAAG TAGCAGTCAC ACCCTAGCCA CTGCTGGGAC 2640

CTTGTGTTCC CCAAGAGTAT CTGATTCCTC TGCTGTCCCT GCCAGGAGCT GAAGGGTGGG 2700

75 AACAACAAAG GCAATGGTGA AAAGAGATTA GGAACCCCCC AGCCTGTTTC CATTCTCTGC 2760

CCAGCAGTCT CTTACCTTCC CTGATCTTTG CAGGGTGGTC CGTGTAAATA GTATAAATTC 2820

TCCAAATTAT CCTCTAATTA TAAATGTAAG CTTATTTCCT TAGATCATTA TCCAGAGACT 2880

GCCAGAAGGT GGGTAGGATG ACCTGGGGTT TCAATTGACT TCTGTTCCTT GCTTTTAGTT 2940

TTGATAGAAG GGAAGACCTG CAGTGCACGG TTTCTTCCAG GCTGAGGTAC CTGGATCTTG 3000

80 GGTTCTTCAC TGCAGGGACC CAGACAAGTG GATCTGCTTG CCAGAGTCCT TTTTGCCCCT 3060

CCCTGCCACC TCCCCGTGTT TCCAAGTCAG CTTTCCTGCA AGAAGAAATC CTGGTTAAAA 3120

AAGTCTTTTG TATTGGGTCA GGAGTTGAAT TTGGGGTGGG AGGATGGATG CAACTGAAGC 3180

AGAGTGTGGG TGCCCAGATG TGCGCTATTA GATGTTTCTC TGATAATGTC CCCAATCATA 3240

. CCAGGGAGAC TGGCATTGAC GAGAACTCAG GTGGAGGCTT GAGAAGGCCG AAAGGGCCCC 3300

85 TGACCTGCCT GGCTTCCTTA GCTTGCCCCT CAGCTTTGCA AAGAGCCACC CTAGGCCCCA 3360

GCTGACCGCA TGGGTGTGAG CCAGCTTGAG AACACTAACT ACTCAATAAA AGCGAAGGTG 3420

GACCNAAAAA AAAAAAAAAA AAAA Seq ID NO: 69 Protein sequence: Protein Accession #: NP_068772.1

1 11 21 31 41 51

I 1 I I I I

MKASPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 60

GIKIINHPTM PNTQWAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 120

LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCADG EAAGCTINNS 180

LSNIQWLRKM SSDGLGSRSI KQEMEEKENC HLEQRQVKVE EPSRPSASWQ NSVSERPPYS 240

YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS 300

ANGKVSFWTI HPSANRYLTL DQVFKPLDPG SPQLPEHLES QQKRPNPELR RNMTIKTELP 360

LGARRKMKPL LPRVSSYLVP IQFPVNQSLV LQPSVKVPLP LAASLMSSEL ARHSKRVRIA 420

PKVLLAEEGI APLSSAGPGK EEKLLFGEGF SPLLPVQTIK EEEIQPGEEM PHLARPIKVE 480

SPPLEEWPSP APSFKEESSH SWEDSSQSPT PRPKKSYSGL RSPTRCVSEM LVIQHRERRE 540

RSRSRRKQHL LPPCVDEPEL LFSEGPSTSR WAAELPFPAD SSDPASQLSY SQEVGGPFKT 600

PIKETLPISS TPSKSVLPRT PESWRLTPPA KVGGLDFSPV QTSQGASDPL PDPLGLMDLS 660

TTPLQSAPPL ESPQRLLSSE PLDLISVPFG NSSPSDIDVP KPGSPEPQVS GLAANRSLTE 720 GLVLDTMNDS LSKILLDISF PGLDEDPLGP DNINWSQFIP ELQ

Seq ID NO: 70 DNA sequence

Nucleic Acid Accession # : BC006529.1

Coding sequence: 178-2424

1 11 21 31 41 51

I I I I 1 I

GGCACGAGGG GGACCCGGCC GGTCCGGCGC GAGCCCCCGT CCGGGGCCCT GGCTCGGCCC 60

CCAGGTTGGA GGAGCCCGGA GCCCGCCTTC GGAGCTACGG CCTAACGGCG GCGGCGACTG 120

CAGTCTGGAG GGTCCACACT TGTGATTCTC AATGGAGAGT GAAAACGCAG ATTCATAATG 180

AAAACTAGCC CCCGTCGGCC ACTGATTCTC AAAAGACGGA GGCTGCCCCT TCCTGTTCAA 240

AATGCCCCAA GTGAAACATC AGAGGAGGAA CCTAAGAGAT CCCCTGCCCA ACAGGAGTCT 300

AATCAAGCAG AGGCCTCCAA GGAAGTGGCA GAGTCCAACT CTTGCAAGTT TCCAGCTGGG 360

ATCAAGATTA TTAACCACCC CACCATGCCC AACACGCAAG TAGTGGCCAT CCCCAACAAT 420

GCTAATATTC ACAGCATCAT CACAGCACTG ACTGCCAAGG GAAAAGAGAG TGGCAGTAGT 480

GGGCCCAACA AATTCATCCT CATCAGCTGT GGGGGAGCCC CAACTCAGCC TCCAGGACTC 540

CGGCCTCAAA CCCAAACCAG CTATGATGCC AAAAGGACAG AAGTGACCCT GGAGACCTTG 600

GGACCAAAAC CTGCAGCTAG GGATGTGAAT CTTCCTAGAC CACCTGGAGC CCTTTGCGAG 660

CAGAAACGGG AGACCTGTGC AGATGGTGAG GCAGCAGGCT GCACTATCAA CAATAGCCTA 720

TCCAACATCC AGTGGCTTCG AAAGATGAGT TCTGATGGAC TGGGCTCCCG CAGCATCAAG 780

CAAGAGATGG AGGAAAAGGA GAATTGTCAC CTGGAGCAGC GACAGGTTAA GGTTGAGGAG 840

CCTTCGAGAC CATCAGCGTC CTGGCAGAAC TCTGTGTCTG AGCGGCCACC CTACTCTTAC 900

ATGGCCATGA TACAATTCGC CATCAACAGC ACTGAGAGGA AGCGCATGAC TTTGAAAGAC 960

ATCTATACGT GGATTGAGGA CCACTTTCCC TACTTTAAGC ACATTGCCAA GCCAGGCTGG 1020

AAGAACTCCA TCCGCCACAA CCTTTCCCTG CACGACATGT TTGTCCGGGA GACGTCTGCC 1080

AATGGCAAGG TCTCCTTCTG GACCATTCAC CCCAGTGCCA ACCGCTACTT GACATTGGAC 1140

CAGGTGTTTA AGCAGCAGAA ACGACCGAAT CCAGAGCTCC GCCGGAACAT GACCATCAAA 1200

ACCGAACTCC CCCTGGGCGC ACGGCGGAAG ATGAAGCCAC TGCTACCACG GGTCAGCTCA 1260

TACCTGGTAC CTATCCAGTT CCCGGTGAAC CAGTCACTGG TGTTGCAGCC CTCGGTGAAG 1320

GTGCCATTGC CCCTGGCGGC TTCCCTCATG AGCTCAGAGC TTGCCCGCCA TAGCAAGCGA 1380

GTCCGCATTG CCCCCAAGGT GCTGCTAGCT GAGGAGGGGA TAGCTCCTCT TTCTTCTGCA 1440

GGACCAGGGA AAGAGGAGAA ACTCCTGTTT GGAGAAGGGT TTTCTCCTTT GCTTCCAGTT 1500

CAGACTATCA AGGAGGAAGA AATCCAGCCT GGGGAGGAAA TGCCACACTT AGCGAGACCC 1560

ATCAAAGTGG AGAGCCCTCC CTTGGAAGAG TGGCCCTCCC CGGCCCCATC TTTCAAAGAG 1620

GAATCATCTC ACTCCTGGGA GGATTCGTCC CAATCTCCCA CCCCAAGACC CAAGAAGTCC 1680

TACAGTGGGC TTAGGTCCCC AACCCGGTGT GTCTCGGAAA TGCTTGTGAT TCAACACAGG 1740

GAGAGGAGGG AGAGGAGCCG GTCTCGGAGG AAACAGCATC TACTGCCTCC CTGTGTGGAT 1800

GAGCCGGAGC TGCTCTTCTC AGAGGGGCCC AGTACTTCCC GCTGGGCCGC AGAGCTCCCG 1860

TTCCCAGCAG ACTCCTCTGA CCCTGCCTCC CAGCTCAGCT ACTCCCAGGA AGTGGGAGGA 1920

CCTTTTAAGA CACCCATTAA GGAAACGCTG CCCATCTCCT CCACCCCGAG CAAATCTGTC 1980

CTCCCCAGAA CCCCTGAATC CTGGAGGCTC ACGCCCCCAG CCAAAGTAGG GGGACTGGAT 2040

TTCAGCCCAG TACAAACCCC CCAGGGTGCC TCTGACCCCT TGCCTGACCC CCTGGGGCTG 2100

ATGGATCTCA GCACCACTCC CTTGCAAAGT GCTCCCCCCC TTGAATCACC GCAAAGGCTC 2160

CTCAGTTCAG AACCCTTAGA CCTCATCTCC GTCCCCTTTG GCAACTCTTC TCCCTCAGAT 2220

ATAGACGTCC CCAAGCCAGG CTCCCCGGAG CCACAGGTTT CTGGCCTTGC AGCCAATCGT 2280

TCTCTGACAG AAGGCCTGGT CCTGGACACA ATGAATGACA GCCTCAGCAA GATCCTGCTG 2340

GACATCAGCT TTCCTGGCCT GGACGAGGAC CCACTGGGCC CTGACAACAT CAACTGGTCC 2400

CAGTTTATTC CTGAGCTACA GTAGAGCCCT GCCCTTGCCC CTGTGCTCAA GCTGTCCACC 2460

ATCCCGGGCA CTCCAAGGCT CAGTGCACCC CAAGCCTCTG AGTGAGGACA GCAGGCAGGG 2520

ACTGTTCTGC TCCTCATAGC TCCCTGCTGC CTGATTATGC AAAAGTAGCA GTCACACCCT 2580

AGCCACTGCT GGGACCTTGT GTTCCCCAAG AGTATCTGAT TCCTCTGCTG TCCCTGCCAG 2640

GAGCTGAAGG GTGGGAACAA CAAAGGCAAT GGTGAAAAGA GATTAGGAAC CCCCCAGCCT 2700

GTTTCCATTC TCTGCCCAGC AGTCTCTTAC CTTCCCTGAT CTTTGCAGGG TGGTCCGTGT 2760

AAATAGTATA AATTCTCCAA ATTATCCTCT AATTATAAAT GTAAGCTTAT TTCCTTAGAT 2820

CATTATCCAG AGACTGCCAG AAGGTGGGTA GGATGACCTG GGGTTTCAAT TGACTTCTGT 2880

TCCTTGCTTT TAGTTTTGAT AGAAGGGAAG ACCTGCAGTG CACGGTTTCT TCCAGGCTGA 2940

GGTACCTGGA TCTTGGGTTC TTCACTGCAG GGACCCAGAC AAGTGGATCT GCTTGCCAGA 3000

GTCCTTTTTG CCCCTCCCTG CCACCTCCCC GTGTTTCCAA GTCAGCTTTC CTGCAAGAAG 3060

AAATCCTGGT TAAAAAAGTC TTTTGTATTG GGTCAGGAGT TGAATTTGGG GTGGGAGGAT 3120

GGATGCAACT GAAGCAGAGT GTGGGTGCCC AGATGTGCGC TATTAGATGT TTCTCTGATA 3180

ATGTCCCCAA TCATACCAGG GAGACTGGCA TTGACGAGAA CTCAGGTGGA GGCTTGAGAA 3240

GGCCGAAAGG GCCCCTGACC TGCCTGGCTT CCTTAGCTTG CCCCTCAGCT TTGCAAAGAG 3300

CCACCCTAGG CCCCAGCTGA CCGCATGGGT GTGAGCCAGC TTGAGAACAC TAACTACTCA 3360 ATAAAAGCGA AGGTGGAAAA AAAAAAAAAA AAAAAAA

Seq ID NO: 71 Protein sequence: Protein Accession ft: AAH06529.1 1 11 21 31 41 51

I I I I I I

MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 60 GIKIINHPTM PNTQWAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 120

LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCADG EAAGCTINNS 180

LSNIQWLRKM SSDGLGSRSI KQEMEEKENC HLEQRQVKVE EPSRPSASWQ NSVSERPPYS 240

YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS 300

ANGKVSFWTI HPSANRYLTL DQVFKQQKRP NPELRRNMTI KTELPLGARR KMKPLLPRVS 360 SYLVPIQFPV NQSLVLQPSV KVPLPLAASL MSSELARHSK RVRIAPKVLL AEEGIAPLSS 420

AGPGKEEKLL FGEGFSPLLP VQTIKEEEIQ PGEEMPHLAR PIKVESPPLE EWPSPAPSFK 480

EESSHSWEDS SQSPTPRPKK SYSGLRSPTR CVSEMLVIQH RERRERSRSR RKQHLLPPCV 540

DEPELLFSEG PSTSRWAAEL PFPADSSDPA SQLSYSQEVG GPFKTPIKET LPISSTPSKS 600

VLPRTPESWR LTPPAKVGGL DFSPVQTPQG ASDPLPDPLG LMDLSTTPLQ SAPPLESPQR 660 LLSSEPLDLI SVPFGNSSPS DIDVPKPGSP EPQVSGLAAN RSLTEGLVLD TMNDSLSKIL 720

LDISFPGLDE DPLGPDNIN SQFIPELQ

Seq ID NO: 72 DNA sequence Nucleic Acid Accession #: U74612.1 Coding sequence: 178-2583

1 11 21 31 41 51

I 1 I I 1 I

GGCACGAGGG GGACCCGGCC GGTCCGGCGC GAGCCCCCGT CCGGGGCCCT GGCTCGGCCC 60

CCAGGTTGGA GGAGCCCGGA GCCCGCCTTC GGAGCTACGG CCTAACGGCG GCGGCGACTG 120

CAGTCTGGAG GGTCCACACT TGTGATTCTC AATGGAGAGT GAAAACGCAG ATTCATAATG 180

AAAACTAGCC CCCGTCGGCC ACTGATTCTC AAAAGACGGA GGCTGCCCCT TCCTGTTCAA' 240

AATGCCCCAA GTGAAACATC AGAGGAGGAA CCTAAGAGAT CCCCTGCCCA ACAGGAGTCT 300

AATCAAGCAG AGGCCTCCAA GGAAGTGGCA GAGTCCAACT CTTGCAAGTT TCCAGCTGGG 360

ATCAAGATTA TTAACCACCC CACCATGCCC AACACGCAAG TAGTGGCCAT CCCCAACAAT 420

GCTAATATTC ACAGCATCAT CACAGCACTG ACTGCCAAGG GAAAAGAGAG TGGCAGTAGT 480

GGGCCCAACA AATTCATCCT CATCAGCTGT GGGGGAGCCC CAACTCAGCC TCCAGGACTC 540

CGGCCTCAAA CCCAAACCAG CTATGATGCC AAAAGGACAG AAGTGACCCT GGAGACCTTG 600 GGACCAAAAC CTGCAGCTAG GGATGTGAAT CTTCCTAGAC CACCTGGAGC CCTTTGCGAG 660

CAGAAACGGG AGACCTGTGC AGATGGTGAG GCAGCAGGCT GCACTATCAA CAATAGCCTA 720

TCCAACATCC AGTGGCTTCG AAAGATGAGT TCTGATGGAC TGGGCTCCCG CAGCATCAAG 780

CAAGAGATGG AGGAAAAGGA GAATTGTCAC CTGGAGCAGC GACAGGTTAA GGTTGAGGAG 840

CCTTCGAGAC CATCAGCGTC CTGGCAGAAC TCTGTGTCTG AGCGGCCACC CTACTCTTAC 900

ATGGCCATGA TACAATTCGC CATCAACAGC AGTGAGAGGA AGCGCATGAC TTTGAAAGAC 960

ATCTATACGT GGATTGAGGA CCACTTTCCC TACTTTAAGC ACATTGCCAA GCCAGGCTGG 1020

AAGAACTCCA TCCGCCACAA CCTTTCCCTG CACGACATGT TTGTCCGGGA GACGTCTGCC 1080

AATGGCAAGG TCTCCTTCTG GACCATTCAC CCCAGTGCCA ACCGCTACTT GACATTGGAC 1140

CAGGTGTTTA AGCCACTGGA CCCAGGGTCT CCACAATTGC CCGAGCACTT GGAATCACAG 1200

CAGAAACGAC CGAATCCAGA GCTCCGCCGG AACATGACCA TCAAAACCGA ACTCCCCCTG 1260

GGCGCACGGC GGAAGATGAA GCCACTGCTA CCACGGGTCA GCTCATACCT GGTACCTATC 1320

CAGTTCCCGG TGAACCAGTC ACTGGTGTTG CAGCCCTCGG TGAAGGTGCC ATTGCCCCTG 1380

GCGGCTTCCC TCATGAGCTC AGAGCTTGCC CGCCATAGCA AGCGAGTCCG CATTGCCCCC 1440

AAGGTTTTTG GGGAACAGGT GGTGTTTGGT TACATGAGTA AGTTCTTTAG TGGCGATCTG 1500 CGAGATTTTG GTACACCCAT CACCAGCTTG TTTAATTTTA TCTTTCTTTG TTTATCAGTG 1560

CTGCTAGCTG AGGAGGGGAT AGCTCCTCTT TCTTCTGCAG GACCAGGGAA AGAGGAGAAA 1620

CTCCTGTTTG GAGAAGGGTT TTCTCCTTTG CTTCCAGTTC AGACTATCAA GGAGGAAGAA 1680

ATCCAGCCTG GGGAGGAAAT GCCACACTTA GCGAGACCCA TCAAAGTGGA GAGCCCTCCC 1740

TTGGAAGAGT GGCCCTCCCC GGCCCCATCT TTCAAAGAGG AATCATCTCA CTCCTGGGAG 1800 GATTCGTCCC AATCTCCCAC CCCAAGACCC AAGAAGTCCT ACAGTGGGCT TAGGTCCCCA 1860

ACCCGGTGTG TCTCGGAAAT GCTTGTGATT CAACACAGGG AGAGGAGGGA GAGGAGCCGG 1920

TCTCGGAGGA AACAGCATCT ACTGCCTCCC TGTGTGGATG AGCCGGAGCT GCTCTTCTCA 1980

GAGGGGCCCA GTACTTCCCG CTGGGCCGCA GAGCTCCCGT TCCCAGCAGA CTCCTCTGAC 2040

CCTGCCTCCC AGCTCAGCTA CTCCCAGGAA GTGGGAGGAC CTTTTAAGAC ACCCATTAAG 2100

GAAACGCTGC CCATCTCCTC CACCCCGAGC AAATCTGTCC TCCCCAGAAC CCCTGAATCC 2160

TGGAGGCTCA CGCCCCCAGC CAAAGTAGGG GGACTGGATT TCAGCCCAGT ACAAACCTCC 2220

CAGGGTGCCT CTGACCCCTT GCCTGACCCC CTGGGGCTGA TGGATCTCAG CACCACTCCC 2280

TTGCAAAGTG CTCCCCCCCT TGAATCACCG CAAAGGCTCC TCAGTTCAGA ACCCTTAGAC 2340

CTCATCTCCG TCCCCTTTGG CAACTCTTCT CCCTCAGATA TAGACGTCCC CAAGCCAGGC 2400

TCCCCGGAGC CACAGGTTTC TGGCCTTGCA GCCAATCGTT CTCTGACAGA AGGCCTGGTC 2460

CTGGACACAA TGAATGACAG CCTCAGCAAG ATCCTGCTGG ACATCAGCTT TCCTGGCCTG 2520

GACGAGGACC CACTGGGCCC TGACAACATC AACTGGTCCC AGTTTATTCC TGAGCTACAG 2580

TAGAGCCCTG CCCTTGCCCC TGTGCTCAAG CTGTCCACCA TCCCGGGCAC TCCAAGGCTC 2640

AGTGCACCCC AAGCCTCTGA GTGAGGACAG CAGGCAGGGA CTGTTCTGCT CCTCATAGCT 2700

CCCTGCTGCC TGATTATGCA AAAGTAGCAG TCACACCCTA GCCACTGCTG GGACCTTGTG 2760

TTCCCCAAGA GTATCTGATT CCTCTGCTGT CCCTGCCAGG AGCTGAAGGG TGGGAACAAC 2820

AAAGGCAATG GTGAAAAGAG ATTAGGAACC CCCCAGCCTG TTTCCATTCT CTGCCCAGCA 2880

GTCTCTTACC TTCCCTGATC TTTGCAGGGT GGTCCGTGTA AATAGTATAA ATTCTCCAAA 2940

TTATCCTCTA ATTATAAATG TAAGCTTATT TCCTTAGATC ATTATCCAGA GACTGCCAGA 3000

AGGTGGGTAG GATGACCTGG GGTTTCAATT GACTTCTGTT CCTTGCTTTT AGTTTTGATA 3060

GAAGGGAAGA CCTGCAGTGC ACGGTTTCTT CCAGGCTGAG GTACCTGGAT CTTGGGTTCT 3120

TCACTGCAGG GACCCAGACA AGTGGATCTG CTTGCCAGAG TCCTTTTTGC CCCTCCCTGC 3180

CACCTCCCCG TGTTTCCAAG TCAGCTTTCC TGCAAGAAGA AATCCTGGTT AAAAAAGTCT 3240

TTTGTATTGG GTCAGGAGTT GAATTTGGGG TGGGAGGATG GATGCAACTG AAGCAGAGTG 3300

TGGGTGCCCA GATGTGCGCT ATTAGATGTT TCTCTGATAA TGTCCCCAAT CATACCAGGG 3360

AGACTGGCAT TGACGAGAAC TCAGGTGGAG GCTTGAGAAG GCCGAAAGGG CCCCTGACCT 3420

GCCTGGCTTC CTTAGCTTGC CCCTCAGCTT TGCAAAGAGC CACCCTAGGC CCCAGCTGAC 3480

CGCATGGGTG TGAGCCAGCT TGAGAACACT AACTACTCAA TAAAAGCGAA GGTGGACAAA 3540 AAAAAAAAAA AAAAA

Seq ID NO: 73 Protein sequence: Protein Accession #: AAC51128.1 1 11 21 31 41 51

I I I 1 I I

MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 60

GIKIINHPTM PNTQWAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 120

LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCADG EAAGCTINNS 180

LSNIQWLRKM SSDGLGSRSI KQEMEEKENC HLEQRQVKVE EPSRPSASWQ NSVSERPPYS 240

YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS 300

ANGKVSFWTI HPSANRYLTL DQVFKPLDPG SPQLPEHLES QQKRPNPELR RNMTIKTELP 360

10 LGARRKMKPL LPRVSSYLVP IQFPVNQSLV LQPSVKVPLP LAASLMSSEL ARHSKRVRIA 420

PKVFGEQWF GYMSKFFSGD LRDFGTPITS LFNFIFLCLS VLLAEEGIAP LSSAGPGKEE 480

KLLFGEGFSP LLPVQTIKEE EIQPGEEMPH LARPIKVESP PLEEWPSPAP SFKEESSHSW 540

EDSSQSPTPR PKKSYSGLRS PTRCVSEMLV IQHRERRERS RSSRKQHLLP PCVDEPELLF 600

SEGPSTSRWA AELPFPADSS DPASQLSYSQ EVGGPFKTPI KETLPISSTP SKSVLPRTPE 660

15 SWRLTPPAKV GGLDFSPVQT SQGASDPLPD PLGLMDLSTT PLQSAPPLES PQRLLSSEPL 720

DLISVPFGNS SPSDIDVPKP GSPEPQVSGL AANRSLTEGL VLDTMNDSLS KILLDISFPG 780 LDEDPLGPDN INWSQFIPEL Q

Seq ID NO: 74 DNA sequence 20 Nucleic Acid Accession #: Eos sequence Coding sequence: 111-416

1 11 21 31 41 51

1Jr G IGGAAGAGCC A IGGCTGAGCC T ITATAAAGGA C ITGCTCTTTG T ICCAAACACA C IACATCTCAC 60

TCATCCTTCT ACTCGTGACG CTTCCCAGCT CTGGCTTTTT GAAAGCAAAG ATGAGCAACA 120

CTCAAGCTGA GAGGTCCATA ATAGGCATGA TCGACATGTT TCACAAATAC ACCAGACGTG 180

ATGACAAGAT TGAGAAGCCA AGCCTGCTGA CGATGATGAA GGAGAACTTC CCCAACTTCC 240

TTAGTGCCTG TGACAAAAAG GGCACAAATT ACCTCGCCGA TGTCTTTGAG AAAAAGGACA 300

30 AGAATGAGGA TAAGAAGATT GATTTTTCTG AGTTTCTGTC CTTGCTGGGA GACATAGCCA 360

CAGACTACCA CAAGCAGAGC CATGGAGCAG CGCCCTGTTC CGGGGGCAGC CAGTGACCCA 420 GCCCCACCAA TGGGCCTCCA GAGACCCCAG GAACAATAAA ATGTCTTCTC CCACCAGA

Seq ID NO: 75 Protein sequence: OD Protein Accession #: Eos sequence

1 11 21 31 41 51

1 I I I I 1

MSNTQAERSI IGMIDMFHKY TRRDDKIEKP SLLTMMKENF PNFLSACDKK GTNYLADVFE 60

40 KKDKNEDKKI DFSEFLSLLG DIATDYHKQS HGAAPCSGGS Q

Seq ID NO: 76 DNA sequence Nucleic Acid Accession #: Eos sequence 45 Coding sequence: 111-416

1 11 21 31 41 51

I I 1 1 I I

GGGAAGAGCC AGGCTGAGCC TTATAAAGGA CTGCTCTTTG TCCAAACACA CACATCTCAC 60

50 TCATCCTTCT ACTCGTGACA CTTCCCAGTT CTGGCTTTTT GAAAGCAAAG ATGAGCAACA 120

CTCAAGCTGA GAGGTCCATA ATAGGCATGA TCGACATGTT TCACAAATAC ACCGGACGTG 180

ATGGCAAGAT TGAGAAGCCA AGCCTGCTGA CGATGATGAA GGAGAACTTC CCCAATTTCC 240

TCAGTGCCTG TGACAAAAAG GGCATACATT ACCTCGCCAC TGTCTTTGAG AAAAAGGACA 300

AGAATGAGGA TAAGAAGATT GATTTTTCTG AGTTTCTGTC CTTGCTGGGA GACATAGCCG 360

55 CAGACTACCA CAAGCAGAGC CATGGAGCGG CGCCCTGTTC TGGGGGAAGC CAGTGATCCA 420 GCCCCACCAA GGGGCCTCCA GAGACCCCAG GAACAATAAG TGTCTCCTCC CACCAGA

Seq ID NO: 77 Protein sequence: Protein Accession #: XP_048124.1

60

1 11 21 31 41 51

I I I I I I

MSNTQAERSI IGMIDMFHKY TGRDGKIEKP SLLTMMKENF PNFLSACDKK GIHYLATVPE 60 KKDKNEDKKI DFSEFLSLLG DIAADYHKQS HGAAPCSGGS Q

65

Seq ID NO: 78 DNA sequence Nucleic Acid Accession #: Z73678.1 Coding sequence: 253-2433

70

1 11 21 31 41 51

G IGGGTGGTGC AIGGGCAGGGG TIGGTATATCC TIGTCTGACGG AIGGGCGGGCC TICGCCAGTGC 60

CAGAGAGGGA CGAACCAGGG TGGAAGCGCC AGGAGCAGCT GCAGGGAGCC CTCACGCGGA 120

75 CCTCGCACTC TATGGCCGTA GGGAGCCGCT GAGAGCGAGA AGAGCACGCT CCTGCCCGCC 180

CGCTGCACCG CACCTCGCCT CGCCTCTCTG CTCTCCTAGG CCCCGGCCGC GCGCCACCCG 240

CCTCCCGCCA CCATGAACCA CTCGCCGCTC AAGACCGCCT TGGCGTACGA ATGCTTCCAG 300

GACCAGGACA ACTCCACGTT GGCTTTGCCG TCGGACCAAA AGATGAAAAC AGGCACGTCT 360

GGCAGGCAGC GCGTGCAGGA GCAGGTGATG ATGACCGTCA AGCGGCAGAA GTCCAAGTCT 420

80 TCCCAGTCGT CCACCCTGAG CCACTCCAAT CGAGGTTCCA TGTATGATGG CTTGGCTGAC 480

AATTACAACT ATGGGACCAC CAGCAGGAGC AGCTACTACT CCAAGTTCCA GGCAGGGAAT 540

GGCTCATGGG GATATCCGAT CTACAATGGA ACCCTCAAGC GGGAGCCTGA CAACAGGCGC 600

TTCAGCTCCT ACAGCCAGAT GGAGAACTGG AGCCGGCACT ACCCCCGGGG CAGCTGTAAC 660

ACCACCGGCG CAGGCAGCGA CATCTGCTTC ATGCAGAAAA TCAAGGCGAG CCGCAGTGAG 720

85 CCCGACCTCT ACTGTGACCC ACGGGGCACC CTGCGCAAGG GCACGCTGGG CAGCAAGGGC 780

CAGAAGACCA CCCAGAACCG CTACAGCTTT TACAGCACCT GCAGTGGTCA GAAGGCCATA 840

AAGAAGTGCC CTGTGCGCCC GCCCTCTTGT GCCTCCAAGC AGGACCCTGT GTATATCCCG 900 CCCATCTCCT GCAACAAGGA CCTGTCCTTT GGCCACTCTA GGGCCAGCTC CAAGATCTGC 960 AGTGAGGACA TCGAGTGCAG TGGGCTGACC ATCCCCAAGG CTGTGCAGTA CCTGAGCTCC 1020 CAGGATGAGA AGTACCAGGC CATTGGGGCC TATTACATCC AGCATACCTG CTTCCAGGAT 1080 GAATCTGCCA AGCAACAGGT CTATCAGCTG GGAGGCATCT GCAAGCTGGT GGACCTCCTC 1140 CGCAGCCCCA ACCAGAACGT CCAGCAGGCC GCGGCAGGGG CCCTGCGCAA CCTGGTGTTC 1200 AGGAGCACCA CCAACAAGCT GGAGACCCGG AGGCAGAATG GGATCCGCGA GGCAGTCAGC 1260 CTCCTGAGGA GAACCGGGAA CGCCGAGATC CAGAAGCAGC TGACTGGGCT GCTCTGGAAC 1320 CTGTCTTCCA CTGACGAGCT GAAGGAGGAA CTCATTGCCG ACGCCCTGCC TGTTCTGGCC 1380 GACCGCGTCA TCATTCCCTT CTCTGGCTGG TGCGATGGCA ATAGCAACAT GTCCCGGGAA 1440 GTGGTGGACC CTGAGGTCTT CTTCAATGCC ACAGGCTGCT TGAGGAACCT GAGCTCGGCC 1500 GATGCAGGCC GCCAGACCAT GCGTAACTAC TCAGGGCTCA TTGATTCCCT CATGGCCTAT 1560 GTCCAGAACT GTGTAGCGGC CAGCCGCTGT GACGACAAGT CTGTGGAAAA CTGCATGTGT 1620 GTTCTGCACA ACCTCTCCTA CCGCCTGGAC GCCGAGGTGC CCACCCGCTA CCGCCAGCTG 1680 GAGTATAACG CCCGCAACGC CTACACCGAG AAGTCCTCCA CTGGCTGCTT CAGCAACAAG 1740 AGCGACAAGA TGATGAACAA CAACTATGAC TGCCCCCTGC CTGAGGAAGA GACCAACCCC 1800 AAGGGCAGCG GCTGGTTGTA CCATTCAGAT GCCATCCGCA CCTACCTGAA CCTCATGGGC 1860 AAGAGCAAGA AAGATGCTAC CCTGGAGGCC TGTGCTGGTG CCCTGCAGAA CCTGACAGCC 1920 AGCAAGGGGC TGATGTCCAG TGGCATGAGC CAGTTGATTG GGCTGAAGGA AAAGGGCCTG 1980 CCACAAATTG CCCGCCTCCT GCAATCTGGC AACTCTGATG TGGTGCGGTC CGGAGCCTCC 2040 CTCCTGAGCA ACATGTCCCG CCACCCTCTG CTGCACAGAG TGATGGGGAA CCAGGTGTTC 2100 CCGGAGGTGA CCAGGCTCCT CACCAGCCAC ACTGGCAATA CCAGCAACTC CGAAGACATC 2160 TTGTCCTCGG CCTGCTACAC TGTGAGGAAC CTGATGGCCT CGCAGCCACA ACTGGCCAAG 2220 CAGTACTTCT CCAGCAGCAT GCTCAACAAC ATCATCAACC TGTGCCGAAG CAGTGCCTCA 2280 CCCAAGGCCG CAGAAGCTGC CCGGCTTCTC CTGTCTGACA TGTGGTCCAG CAAGGAACTG 2340 CAGGGTGTCC TCAGACAGCA AGGTTTCGAT AGGAACATGC TGGGAACCTT AGCTGGGGCC 2400 AACAGCCTCA GGAACTTCAC CTCCCGATTC TAAGAAGAGA CTGTCCAAGC AAGTΓAGGCT 2460 TGCAGGAAGA TATGACCCAG CTGAGAAGCC CTCAGGCCTC GCTGGATGGG GTTTTCTGTC 2520 CATCCTGTGC AGTATTTGGG AAAGTTCACA AGAAACTGAG AAGAAACCTA AAAACTGTGG 2580 ATAGTGGAAA GATTTTTAGA TTTTTTTTTT CCTTGGGGAA ACTGGCAGGC AATGGGGGTT 2640 AGGGAGGTTG GGGCGGGGGG GGCTTTCTTG AGTTAAAGGG GCTTATATGT GATGTCAATA 2700 TTTCTTCCTC TGAGAAATGG TATATATATG TGTCTAATGT AAGTGTGTGC ATGCATGTGC 2760 GCGTGCATGT GTGTGTGTGT GAGTGTCTTA AAGCATAACC ACAAACTGCA AAAAGCTAGG 2820 TAAGCTATTT TGTTGCAGCT CATAAGGTGG TGAAAAGGAC TCTCCTGTGT TTCTTACTCA 2880 TAGGCAAGGA CAACATGTGC TTTTTGGTGA GCTGCTCATA ATTCCTGAAA TGTGTGGTGC 2940 CAGGGCAAGG GGGCCATCAC TGCAGTCAGG CCCTCAGAGG AGTCCTGCAG GCTTCCTACC 3000 AGTGGTCTCC AAGGGTGCAG GAGTAACTGG GGCTGGGCCA GCCTCCCCCC TTACAAGGCT 3060 GCTTTCCACG AAGGGAGGTC TGGTGTATCT CATGGGAGAA TCTGGGGTGT CTGTAGTGTC 3120 ACCCCTCCAG CAGCGCCACA AGGACTGAGG TTGGGTAGGT GTGAGGTTCC AGAGGACAGC 3180 AGGACACTCT CGCATACTTT GCCAAATGAG GCCTGCTCAG AGGAGΓAGGA GCTGAAAGAT 3240 GGTGCCTTCC ACCCTCTTGG GCTGTGTGCC CATCAGAGCA GGCTCAGCCT GCAAAGGCCC 3300 TGCATTCAGA GGTCTTGTAA TCTACTTGTT GCAGGAGAAA GAAGGTAAAA AATGATTTTT 3360 TTAAGAAAAG CTATTTTATT GCAGCTCTTT CCCAAGAGCT GTTCTGGGAA TGGCTGGTCT 3420 TCATATTCCC AGTGGAGAGG GGAACAAGTG GGGCTGGGCA TATACCTATT CCGGCTTCTA 3480 GTGGGATGGA GTTGGGGTAT AGAAATTAAC CAGGAAGATG TTTCCACCAA GCCTGCTGTG 3540 AGTCAATTGA GGGAGTGTTT GGGTCCCAGG AGACTTGGAC GGGGGGAGTT TGGGTAGACT 3600 AGGAAAGGAA AGTGCCATAT CAGGGTACCG GTACCGGCAA GCTCACATCT CAGCCAGGGG 3660 CCATGCCCCA CTTCCCCTGA CCCCAGCTGT CTTGTCTCCA CTCTGTGAAA CCCACAGGGG 3720 ATGTGATAAA CAGGGCTATT AGGGGTATCA GCCACGTCGA GCCCCCAGAC TCTGTGCACT 3780 TCAGACCAGC AGCAGCAGGA GGGCTCCCGA GGGCCTTATG AGAAAACCTG TGTGGACATC 3840 CCTTGGTGTA CACTAAGACA GAGCAGAGCC CAGCGCTCCC AAGCCTTCCT CCTTCCAGCT 3900 TCTACCTCCA TGCTAGCATT GCTGGTGTTA GAGAGGAATT AACTTCCTGG TCTGTGCCCT 3960 TCTCTAGAAG AATATAAGAT GCTCCTCCTC CTCACCCCTT CTCAGCCTCC TCCCAAGTCT 4020 TCCTCTTCTG CACCACCCCC GAGTCCAAAC CCACCTCTTG CCCCAGCATT CAGGCTGGAA 4080 AACACTGATG TGGACTCAGT ATGACAACTG AGATGGGGGA AGCCAGACAT GTGAGGACGC 4140 TGTCCTCCGA GAGGTGTCCC CGGCTGTTAG CCAGCTGTGC TGTGGTGCTG TGGGTCTGTC 4200 ATACCCTCCC TTGCTTCTGT TCACACTGGG AGGCCCACTC CTGGCTCACC TCTCCCTCTC 4260 AGGGACCCAC GTGGGAGCCT GGATCCCTGG ACTGTCCTGG GCATAGGTTT CAGGGGCCTC 4320 CTTTGTTGTC ATCAGAACCC AGAGGAATTC TTCTCCTAAA AAATACGTAT GGCATACCAA 4380 TCTGTGCGGG GCAGTGTCCT AAGCACTTAG ACTACATCAG GGAAGAACAC AGACCACATC 4440 CCCGTCCTCA TGCGGCTTAT GTTTTCTGGA GGAAAGTGGA GACACAAGTC CTTGGCTTTA 4500 GGGCTCCCCC GGCTGGGGGC TGTGCAGTCC GGTCAGGGCG GGAGGGGAAA TGCACCGCTG 4560 CATGTGAACC TTACCAGCCC AGGCGGATGC CCCTTCCCCT TAGCACTACC CTGGCCTCCT 4620 GCATCCCCTC GCCTCATGTT CCTCCCACCT TCAAAGAATG AAGAGCCCCA TGGGCCCAGC 4680 CCCTGCCCTG GGAACCAGGC AGCCTTCCAG ACCTCAGGGG CTGAGGCAGA CTATTAGGGC 4740 AGGGCTGACT TTGGTGACAC TGCCCATTCC CTCTCAGGCC AGCTCAGGTC ACCCGGGCCT 4800 CTGACCCAGG CCTGTCACTT TGAGAGGGGC AAAACTGAGA GGGGCTTTTC CTAGAGAAAG 4860 AGAACAAGGA GCTTGCCAGG CTTCATGTAG CCGACACACG TCTCAGGATT TTAAGTCCAC 4920 ATTGGCCTCA CACTAGCCTA GGCCAATGCC CAAAATAAGG AGTTCCAATT TGGGGCCAAA 4980 TGAGGAAGGA CACACJACTCT GCCCTGGGAT CTCCTGTGCT AGCGGCCAAT GACAAATCCA 5040 GTCATTGGCC ACCAGCCACC TCTGCAGTGG GGACCACACT AGCAGCCCTG ACTCCACACT 5100 CCTCCTGGGG ACCCAAGAGG CAGTGTTGCT GTCTGCGTGT CCACCTTGGA ATCTGGCTGA 5160 ACTGGCTGGG AGGACCAAGA CTGCGGCTGG GGTGGGCAGG GAAGGGAAGC CGGGGGCTGC 5220 TGTGAGGGAT CTTGGAGCTT CCCTGTAGCC CACCTTCCCC TTGCTTCATG TTTGTAGAGG 5280 AACCTTGTGC CGGCCAGGCC CAGTTTCCTT GTGTGATACA CTAATGTATT TGCΓTTTTTT 5340 GGAAATAGAG AAAATCAATA AATTGCTAGT GTTTCTTTGA AAAAAAAAA

Seq ID NO: 79 Protein sequence: Protein Accession #: CAA98022.1

11 21 31 41 51

I

MNHSPLKTAL I

AYECFQDQDN STLALPSDQK MKTGTSGRQR V IQEQVMMTVK I

RQKSKSSQSS 60 TLSHSNRGSM YDGLADNYNY GTTSRSSYYS KFQAGNGSWG YPIYNGTL R EPDNRRFSSY 120 SQMENWSRHY PRGSCNTTGA GSDICFMQKI KASRSEPDLY CDPRGTLRKG TLGSKGQKTT 180 QNRYSFYSTC SGQKAIKKCP VRPPSCASKQ DPVYIPPISC NKDLSFGHSR ASSKICSEDI 240 ECSGLTIPKA VQYLSSQDEK YQAIGAYYIQ HTCFQDESAK QQVYQLGGIC KLVDLLRSPN 300 QNVQQAAAGA LRNLVFRSTT NKLETRRQNG IREAVSLLRR TGNAEIQKQL TGLLWNLSST 360 DELKEELIAD ALPVLADRVI IPFSGWCDGN SNMSREWDP EVFFNATGCL RNLSSADAGR 420

QTMRNYSGLI DSLMAYVQNC VAASRCDDKS VENCMCVLHN LSYRLDAEVP TRYRQLEYNA 480

RNAYTEKSST GCFSNKSDKM MNNNYDCPLP EEETNPKGSG WLYHSDAIRT YLNLMGKSKK 540

DATLEACAGA LQNLTASKGL MSSGMSQLIG LKEKGLPQIA RLLQSGNSDV VRSGASLLSN 600

MSRHPLLHRV MGNQVFPEVT RLLTSHTGNT SNSEDILSSA CYTVRNLMAS QPQLAKQYFS 660

SSMLNNIINL CRSSASPKAA EAARLLLSDM WSSKELQGVL RQQGFDRNML GTLAGANSLR 720 NFTSRF Seq ID NO: 80 DNA sequence

Nucleic Acid Accession ft: NM_006516.1 Coding sequence: 180-1658

11 21 31 41 51

I I I I I

TAGTCGCGGG TCCCCGAGTG AGCACGCCAG GGAGCAGGAG ACCAAACGAC GGGGGTCGGA 60 GTCAGAGTCG CAGTGGGAGT CCCCGGACCG GAGCACGAGC CTGAGCGGGA GAGCGCCGCT 120 CGCACGCCCG TCGCCACCCG CGTACCCGGC GCAGCCAGAG CCACCAGCGC AGCGCTGCCA 180 TGGAGCCCAG CAGCAAGAAG CTGACGGGTC GCCTCATGCT GGCTGTGGGA GGAGCAGTGC 240 TTGGCTCCCT GCAGTTTGGC TACAACACTG GAGTCATCAA TGCCCCCCAG AAGGTGATCG 300 AGGAGTTCTA CAACCAGACA TGGGTCCACC GCTATGGGGA GAGCATCCTG CCCACCACGC 360 TCACCACGCT CTGGTCCCTC TCAGTGGCCA TCTTTTCTGT TGGGGGCATG ATTGGCTCCT 420 TCTCTGTGGG CCTTTTCGTT AACCGCTTTG GCCGGCGGAA TTCAATGCTG ATGATGAACC 480 TGCTGGCCTT CGTGTCCGCC GTGCTCATGG GCTTCTCGAA ACTGGGCAAG TCCTTTGAGA 540 TGCTGATCCT GGGCCGCTTC ATCATCGGTG TGTACTGCGG CCTGACCACA GGCTTCGTGC 600 CCATGTATGT GGGTGAAGTG TCACCCACAG CCTTTCGTGG GGCCCTGGGC ACCCTGCACC 660 AGCTGGGCAT CGTCGTCGGC ATCCTCATCG CCCAGGTGTT CGGCCTGGAC TCCATCATGG 720 GCAACAAGGA CCTGTGGCCC CTGCTGCTGA GCATCATCTT CATCCCGGCC CTGCTGCAGT 780 GCATCGTGCT GCCCTTCTGC CCCGAGAGTC CCCGCTTCCT GCTCATCAAC CGCAACGAGG 840 AGAACCGGGC CAAGAGTGTG CTAAAGAAGC TGCGCGGGAC AGCTGACGTG ACCCATGACC 900 TGCAGGAGAT GAAGGAAGAG AGTCGGCAGA TGATGCGGGA GAAGAAGGTC ACCATCCTGG 960 AGCTGTTCCG CTCCCCCGCC TACCGCCAGC CCATCCTCAT CGCTGTGGTG CTGCAGCTGT 1020 CCCAGCAGCT GTCTGGCATC AACGCTGTCT TCTATTACTC CACGAGCATC TTCGAGAAGG 1080 CGGGGGTGCA GCAGCCTGTG TATGCCACCA TTGGCTCCGG TATCGTCAAC ACGGCCTTCA 1140 CTGTCGTGTC GCTGTTTGTG GTGGAGCGAG CAGGCCGGCG GACCCTGCAC CTCATAGGCC 1200 TCGCTGGCAT GGCGGGTTGT GCCATACTCA TGACCATCGC GCTAGCACTG CTGGAGCAGC 1260 TACCCTGGAT GTCCTATCTG AGCATCGTGG CCATCTTTGG CTTTGTGGCC TTCTTTGAAG 1320 TGGGTCCTGG CCCCATCCCA TGGTTCATCG TGGCTGAACT CTTCAGCCAG GGTCCACGTC 1380 CAGCTGCCAT TGCCGTTGCA GGCTTCTCCA ACTGGACCTC AAATTTCATT GTGGGCATGT 1440 GCTTCCAGTA TGTGGAGCAA CTGTGTGGTC CCTACGTCTT CATCATCTTC ACTGTGCTCC 1500 TGGTTCTGTT CTTCATCTTC ACCTACTTCA AAGTTCCTGA GACTAAAGGC CGGACCTTCG 1560 ATGAGATCGC TTCCGGCTTC CGGCAGGGGG GAGCCAGCCA AAGTGATAAG ACACCCGAGG 1620 AGCTGTTCCA TCCCCTGGGG GCTGATTCCC AAGTGTGAGT CGCCCCAGAT CACCAGCCCG 1680 GCCTGCTCCC AGCAGCCCTA AGGATCTCTC AGGAGCACAG GCAGCTGGAT GAGACTTCCA 1740 AACCTGACAG ATGTCAGCCG AGCCGGGCCT GGGGCTCCTT TCTCCAGCCA GCAATGATGT 1800 CCAGAAGAAT ATTCAGGACT TAACGGCTCC AGGATTTTAA CAAAAGCAAG ACTGTTGCTC 1860 AAATCTATTC AGACAAGCAA CAGGTTTTAT AATTTTTTTA TTACTGATTT TGTTATTTTT 1920 ATATCAGCCT GAGTCTCCTG TGCCCACATC CCAGGCTTCA CCCTGAATGG TTCCATGCCT 1980 GAGGGTGGAG ACTAAGCCCT GTCGAGACAC TTGCCTTCTT CACCCAGCTA ATCTGTAGGG 2040 CTGGACCTAT GTCCTAAGGA CACACTAATC GAACTATGAA CTACAAAGCT TCTATCCCAG 2100 GAGGTGGCTA TGGCCACCCG TTCTGCTGGC CTGGATCTCC CCACTCTAGG GGTCAGGCTC 2160 CATTAGGATT TGCCCCTTCC CATCTCTTCC TACCCAACCA CTCAAATTAA TCTTTCTTTA 2220 CCTGAGACCA GTTGGGAGCA CTGGAGTGCA GGGAGGAGAG GGGAAGGGCC AGTCTGGGCT 2280 GCCGGGTTCT AGTCTCCTTT GCACTGAGGG CCACACTATT ACCATGAGAA GAGGGCCTGT 2340 GGGAGCCTGC AAACTCACTG CTCAAGAAGA CATGGAGACT CCTGCCCTGT TGTGTATAGA 2400 TGCAAGATAT TTATATATAT TTTTGGTTGT CAATATTAAA TACAGACACT AAGTTATAGT 2460 ATATCTGGAC AAGCCAACTT GTAAATACAC CACCTCACTC CTGTTACTTA CCTAAACAGA 2520 TATAAATGGC TGGTTTTTAG AAACATGGTT TTGAAATGCT TGTGGATTGA GGGTAGGAGG 2580 TTTGGATGGG AGTGAGACAG AAGTAAGTGG GGTTGCAACC ACTGCAACGG CTTAGACTTC 2640 GACTCAGGAT CCAGTCCCTT ACACGTACCT CTCATCAGTG TCCTCTTGCT CAAAAATCTG 2700 TTTGATCCCT GTTACCCAGA GAATATATAC ATTCTTTATC TTGACATTCA AGGCATTTCT 2760 ATCACATATT TGATAGTTGG TGTTCAAAAA AACACTAGTT TTGTGCCAGC CGTGATGCTC 2820 AGGCTTGAAA TCGCATTATT TTGAATGTGA AGGGAA

Seq ID NO: 81 Protein sequence: Protein Accession #: NP 006507.1

11 41 51

MEPSSKKLTG RLMLAVGGAV LGSLQFGYNT GVINAPQKVI EEFYNQTWVH RYGESILPTT 60

LTTLWSLSVA IFSVGGMIGS FSVGLFVNRF GRRNSMLMMN LLAFVSAVLM GFSKLGKSFE 120

MLILGRFIIG VYCGLTTGFV PMYVGEVSPT AFRGALGTLH QLGIWGILI AQVFGLDSIM 180

GNKDLWPLLL SIIFIPALLQ CIVLPFCPES PRFLLINRNE ENRAKSVLKK LRGTADVTHD 240

LQEMKEESRQ MMREKKVTIL ELFRSPAYRQ PILIAWLQL SQQLSGINAV FYYSTSIFEK 300

AGVQQPVYAT IGSGIVNTAF TWSLFWER AGRRTLHLIG LAGMAGCAIL MTIALALLEQ 360

LPWMSYLSIV AIFGFVAFFE VGPGPIPWFI VAELFSQGPR PAAIAVAGFS NBTSNFIVGM 420

CFQYVEQLCG PYVFIIFTVL LVLFFIFTYF KVPETKGRTF DEIASGFRQG GASQSDKTPE 480

ELFHPLGADS QV

Seq ID NO: 82 DNA sequence Nucleic Acid Accession ft: BC001291 Coding sequence: 44-541

1 11 21 31 41 51

I I I I I I

GGGGGCGCCG CGCGCTGACC CTCCCTGGGC ACCGCTGGGG ACGATGGCGC TGCTCGCCTT 60 GCTGCTGGTC GTGGCCCTAC CGCGGGTGTG GACAGACGCC AACCTGACTG CGAGACAACG 120 AGATCCAGAG GACTCCCAGC GAACGGACGA GGGTGACAAT AGAGTGTGGT GTCATGTTTG 180

TGAGAGAGAA AACACTTTCG AGTGCCAGAA CCCAAGGAGG TGCAAATGGA CAGAGCCATA 240

CTGCGTTATA GCGGCCGTGA AAATATTTCC ACGTTTTTTC ATGGTTGCGA AGCAGTGCTC 300

CGCTGGTTGT GCAGCGATGG AGAGACCCAA GCCAGAGGAG AAGCGGTTTC TCCTGGAAGA 360

GCCCATGCCC TTCTTTTACC TCAAGTGTTG TAAAATTCGC TACTGCAATT TAGAGGGGCC 420

ACCTATCAAC TCATCAGTGT TCAAAGAATA TGCTGGGAGC ATGGGTGAGA GCTGTGGTGG 480

GCTGTGGCTG GCCATCCTCC TGCTGCTGGC CTCCATTGCA GCCGGCCTCA GCCTGTCTTG 540

AGCCACGGGA CTGCCACAGA CTGAGCCTTC CGGAGCATGG ACTCGCTCCA GACCGTTGTC 600

ACCTGTTGCA TTAAACTTGT TTTCTGTTGA TTACCTCTTG GTTTGACTTC CCAGGGTCTT 660

GGGATGGGAG AGTGGGGATC AGGTGCAGTT GGCTCTTAAC CCTCAAGGGT TCTTTAACTC 720

ACATTCAGAG GAAGTCCAGA TCTCCTGAGT AGTGATTTTG GTGACAAGTT TTTCTCTTTG 780

AAATCAAACC TTGTAACTCA TTTATTGCTG ATGGCCACTC TTTTCCTTGA CTCCCCTCTG 840

CCTCTGAGGG CTTCAGTATT GATGGGGAGG GAGGCCTAAG TACCACTCAT GGAGAGTATG 900

TGCTGAGATG CTTCCGACCT TTCAGGTGAC GCAGGAACAC TGGGGGAGTC TGAATGATTG 960

GGGTGAAGAC ATCCCTGGAG TGAAGGACTC CTCAGCATGG GGGGCAGTGG GGCACACGTT 1020

AGGGCTGCCC CCATTCCAGT GGTGGAGGCG CTGTGGATGG CTGCTTTTCC TCAACCTTTC 1080

CTACCAGATT CCAGGAGGCA GAAGATAACT AATTGTGTTG AAGAAACTTA GACTTCACCC 1140

ACCAGCTGGC ACAGGTGCAC AGATTCATAA ATTCCCACAC GTGTGTGTTC AACATCTGAA 1200

ACTTAGGCCA AGTAGAGAGC ATCAGGGTAA ATGGCGTTCA TTTCTCTGTT AAGATGCAGC 1260

CATCCATGGG GAGCTGAGAA ATCAGACTCA AAGTTCCACC AAAAACAAAT ACAAGGGGAC 1320 TTCAAAAGTT CACGAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAA

Seq ID NO: 83 Protein sequence: Protein Accession #: AAH01291

1 11 21 31 41 51

I I 1 I I I

MALLALLLW ALPRVKTDAN LTARQRDPED SQRTDEGDNR VWCHVCEREN TFECQNPRRC 60

KWTEPYCVIA AVKIFPRFFM VAKQCSAGCA AMERPKPEEK RFLLEEPMPF FYLKCCKIRY 120 CNLEGPPINS SVFKEYAGSM GESCGGL LA ILLLLASIAA GLSLS

Seq ID NO: 84 DNA sequence

Nucleic Acid Accession #: NM_022893.1

Coding sequence: 229-2726

1 11 21 31 41 51

I 1 I I I I _{ττττττττττ} TTTTTTG TT AAAAAAAAGC CATGACGGCT CTCCCACAAT TCATCTTCCC 60

TGCGCCATCT TTGTATTATT TCTAATTTAT TTTGGATGTC AAAAGGCACT GATGAAGATA 120

TTTTCTCTGG AGTCTCCTTC TTTCTAACCC GGCTCTCCCG ATGTGAACCG AGCCGTCGTC 180

CGCCCGCCGC CGCCGCCGCC GCCGCCGCCG CCCGCCCCGC AGCCCACCAT GTCTCGCCGC 240

AAGCAAGGCA AACCCCAGCA CTTAAGCAAA CGGGAATTCT CGCCCGAGCC TCTTGAAGCC 300

ATTCTTACAG ATGATGAACC AGACCACGGC CCGTTGGGAG CTCCAGAAGG GGATCATGAC 360

CTCCTCACCT GTGGGCAGTG CCAGATGAAC TTCCCATTGG GGGACATTCT TATTTTTATC 420

GAGCACAAAC GGAAACAATG CAATGGCAGC CTCTGCTTAG AAAAAGCTGT GGATAAGCCA 480

CCTTCCCCTT CACCAATCGA GATGAAAAAA GCATCCAATC CCGTGGAGGT TGGCATCCAG 540

GTCACGCCAG AAGATGACGA TTGTTTATCA ACGTCATCTA GAAGAATTTG CCCCAAACAG 600

GAACACATAG CAGATAAACT TCTGCACTGG AGGGGCCTCT CCTCCCCTCG TTCTGCACAT 660

GGAGCTCTAA TCCCCACGCC TGGGATGAGT GCAGAATATG CCCCGCAGGG TATTTGTAAA 720

GATGAGCCCA GCAGCTACAC ATGTACAACT TGCAAACAGC CATTCACCAG TGCATGGTTT 780

CTCTTGCAAC ACGCACAGAA CACTCATGGA TTAAGAATCT ACTTAGAAAG CGAACACGGA 840

AGTCCCCTGA CCCCGCGGGT TGGTATCCCT TCAGGACTAG GTGCAGAATG TCCTTCCCAG 900

CCACCTCTCC ATGGGATTCA TATTGCAGAC AATAACCCCT TTAACCTGCT AAGAATACCA 960

GGATCAGTAT CGAGAGAGGC TTCCGGCCTG GCAGAAGGGC GCTTTCCACC CACTCCCCCC 1020

CTGTTTAGTC CACCACCGAG ACATCACTTG GACCCCCACC GCATAGAGCG CCTGGGGGCG 1080

GAAGAAATGG CCCTGGCCAC CCATCACCCG AGTGCCTTTG ACAGGGTGCT GCGGTTGAAT 1140

CCAATGGCTA TGGAGCCTCC CGCCATGGAT TTCTCTAGGA GACTTAGAGA GCTGGCAGGG 1200

AACACGTCTA GCCCACCGCT GTCCCCAGGC CGGCCCAGCC CTATGCAAAG GTTACTGCAA 1260

CCATTCCAGC CAGGTAGCAA GCCGCCCTTC CTGGCGACGC CCCCCCTCCC TCCTCTGCAA 1320

TCCGCCCCTC CTCCCTCCCA GCCCCCGGTC AAGTCCAAGT CATGCGAGTT CTGCGGCAAG 1380

ACGTTCAAAT TTCAGAGCAA CCTGGTGGTG CACCGGCGCA GCCACACGGG CGAGAAGCCC 1440

TACAAGTGCA ACCTGTGCGA CCACGCGTGC ACCCAGGCCA GCAAGCTGAA GCGCCACATG 1500

AAGACGCACA TGCACAAATC GTCCCCCATG ACGGTCAAGT CCGACGACGG TCTCTCCACC 1560

GCCAGCTCCC CGGAACCCGG CACCAGCGAC TTGGTGGGCA GCGCCAGCAG CGCGCTCAAG 1620

TCCGTGGTGG CCAAGTTCAA GAGCGAGAAC GACCCCAACC TGATCCCGGA GAACGGGGAC 1680

GAGGAGGAAG AGGAGGACGA GGAGGAAGAG GAAGAAGAGG AGGAAGAGGA GGAGGAGGAG 1740

CTGACGGAGA GCGAGAGGGT GGACTACGGC TTCGGGCTGA GCCTGGAGGC GGCGCGCCAC 1800

CACGAGAACA GCTCGCGGGG CGCGGTCGTG GGCGTGGGCG ACGAGAGCCG CGCCCTGCCC 1860

GACGTCATGC AGGGCATGGT GCTCAGCTCC ATGCAGCACT TCAGCGAGGC CTTCCACCAG 1920

GTCCTGGGCG AGAAGCATAA GCGCGGCCAC CTGGCCGAGG CCGAGGGCCA CAGGGACACT 1980

TGCGACGAAG ACTCGGTGGC CGGCGAGTCG GACCGCATAG ACGATGGCAC TGTTAATGGC 2040

CGCGGCTGCT CCCCGGGCGA GTCGGCCTCG GGGGGCCTGT CCAAAAAGCT GCTGCTGGGC 2100

AGCCCCAGCT CGCTGAGCCC CTTCTCTAAG CGCATCAAGC TCGAGAAGGA GTTCGACCTG 2160

CCCCCGGCCA CGATGCCCAA CACGGAGAAC GTGTACTCGC AGTGGCTCGC CGGCTACGCG 2220

GCCTCCAGGC AGCTCAAAGA TCCCTTCCTT AGCTTCGGAG ACTCCAGACA ATCGCCTTTT 2280

GCCTCCTCGT CGGAGCACTC CTCGGAGAAC GGGAGCTTGC GCTTCTCCAC ACCGCCCGGG 2340

GAGCTGGACG GAGGGATCTC GGGGCGCAGC GGCACGGGAA GTGGAGGGAG CACGCCCCAT 2400

ATTAGTGGTC CGGGCACGGG CAGGCCCAGC TCAAAAGAGG GCAGACGCAG CGACACTTGT 2460

GAGTACTGTG GGAAAGTCTT CAAGAACTGT AGCAATCTCA CTGTCCACAG GAGAAGCCAC 2520

ACGGGCGAAA GGCCTTATAA ATGCGAGCTG TGCAACTATG CCTGTGCCCA GAGTAGCAAG 2580

CTCACCAGGC ACATGAAAAC GCATGGCCAG GTGGGGAAGG ACGTTTACAA ATGTGAAATT 2640

TGTAAGATGC CTTTTAGCGT GTACAGTACC CTGGAGAAAC ACATGAAAAA ATGGCACAGT 2700

GATCGAGTGT TGAATAATGA TATAAAAACT GAATAGAGGT ATATTAATAC CCCTCCCTCA 2760

CTCCCACCTG ACACCCCCTT TTTCACCACT CCCTTTCCCC ATCGCCCTCC AGCCCCACTC 2820

CCTGTAGGAT TTTTTTCTAG TCCCATGTGA TTTAAACAAA CAAACAAACA AACAGAAGTA 2880

ACGAAGCTAA GAATATGAGA GTGCTTGTCA CCAGCACACC TGTTTTTTTT CTTTTTCTTT 2940

TTCTTTTTTC TTTTTCCTTT TTTTTTTTTT TCCTTTATGT TCTCACCGTT TGAATGCATG 3000 ATCTGTATGG GGCAATACTA TTGCATTTTA CGCAAACTTT GAGCCTTTCT CTTGTGCAAT 3060

AATTTACATG TTGTGTATGT TTTTTTTTAA ACTTAGACAG CATGTATGGT ATGTTATGGC 3120

TATTTTAAAT TGTCCCTAAT TCGTTGCTGA GCAAACATGT TGCTGTTTCC AGTTCCGTTC 3180

TGAGAGAAAA AGAGAGAGAG AGAGAAAAAG ACCATGCTGC ATACATTCTG TAATACATAT 3240

CATGTACAGT TTTATTTTAT AACGTGAGGA GGAAAAACAG TCTTTGGATT AACCCTCTAT 3300

AGACAGAATA GATAGCACTG AAAAAAAATC TCTATGAGCT AAATGTCTGT CTCTAAAGGG 3360

TTAAATGTAT CAATTGGAAA GGAAGAAAAA AGGCCTTGAA TTGACAAATT AACAGAAAAA 3420

CAGAACAAGT TTATTCTATC ATTTGGTTTT AAAATATGAG TGCCTTGGAT CTATTAAAAC 3480

CACATCGATG GTTCTTTCTA CTTGTTATAA ACTTGTAGCT TAATTCAGCA TTGGGTGAGG 3540

10 TAATAAACCT TAGGAACTAG CATATAATTC TATATTGTAT TTCTCACAAC AATGGCTACC 3600

TAAAAAGATG ACCCATTATG TCCTAGTTAA TCATCATTTT TCCTTTAGTT TAATTTTATA 3660

AACAAAACTG ATTATACCAG TATAAAAGCT ACTTTGCTCC TGGTGAGAGC TTAAAAGAAA 3720

TGGGCTGTTT TGCCCAAAGT TTTATTTTTT TTAAACAATG ATTAAATTGA ATGTGTAATG 3780

TGCAAAAGCC CTGGAACGCA ATTAAATACA CTAGTAAGGA GTTCATTTTA TGAAGATATT 3840

15 TGCTTTAATA ATGTCTTTTT AAAAATACTG GCACCAAAAG AAATAGATCC AGATCTACTT 3900

GGTTGTCAAG TGGACAATCA AATGATAAAC TTTAAGACCT TGTATACCAT ATTGAAAGGA 3960

AGAGGCTGAC AATAAGGTTT GACAGAGGGG AACAGAAGAA AATAATATGA TTTATTAGCA 4020

CAACGTGGTA CTATTTGCCA TTTAAAACTA GAACAGGTAT ATAAGCTAAT ATTGATACAA 4080

TGATGATTAA CTATGAATTC TTAAGACTTG CATTTAAATG TGACATTCTT AAAAAAAGAA 4140

20 GAGAAAGAAT TTTAAGAGTA GCAGTATATA TGTCTGTGCT CCCTAAAAGT TGTACTTCAT 4200

TTCTTTTCCA TACACTGTGT GCTATTTGTG TTAACATGGA AGAGGATTCA TTGTTTTTAT 4260

TTTTATTTTT TTAATTTTTT CTTTTTTATT AAGCTAGCAT CTGCCCCAGT TGGTGTTCAA 4320

ATAGCACTTG ACTCTGCCTG TGATATCTGT ATCTTTTCTC TAATCAGAGA TACAGAGGTT 4 80

GAGTATAAAA TAAACCTGCT CAGATAGGAC AATTAAGTGC ACTGTACAAT TTTCCCAGTT 4440 5 TACAGGTCTA TACTTAAGGG AAAAGTTGCA AGAATGCTGA AAAAAAATTG AACACAATCT 4500

CATTGAGGAG CATTTTTTAA AAACTAAAAA AAAAAAAACT TTGCCAGCCA TTTACTTGAC 4560

TATTGAGCTT ACTTACTTGG ACGCAACATT GCAAGCGCTG TGAATGGAAA CAGAATACAC 4620

TTAACATAGA AATGAATGAT TGCTTTCGCT TCTACAGTGC AAGGATTTTT TTGTACAAAA 4680

CTTTTTTAAA TATAAATGTT AAGAAAAATT TTTTTTAAAA AACACTTCAT TATGTTTAGG 4740

30 GGGGAACTGC ATTTTAGGGT TCCATTGTCT TGGTGGTGTT ACAAGACTTG TTATCCATTT 4800

AAAAATGGTA GTGGAAATTC TATGCCTTGG ATACACACCG CTCTTCAGGT TGTAAAAAAA 4860

AAAAACATAC ATTGGGGAAA GGTTTAAGAT TATATAGTAC TTAAATATAG GAAAATGCAC 4920

ACTCATGTTG ATTCCTATGC TAAAATACAT TTATGGTCTT TTTTCTGTAT TTCTAGAATG 4980

GTATTTGAAT TAAATGTTCA TCTAGTGTTA GGCACTATAG TATTTATATT GAAGCTTGTA 5040 5 TTTTTAACTG TTGCTTGTTC TCTTAAAAGG TATCAATGTA CCTTTTTTGG TAGTGGAAAA 5100

AAAAAAGACA GGCTGCCACA GTATATTTTT TTAATTTGGC AGGATAATAT AGTGCAAATT 5160

ATTTGTATGC TTCAAAAAAA AAAAAAAGAG AGAAACAAAA AAGTGTGACA TTACAGATGA 5220

GAAGCCATAT AATGGCGGTT TGGGGGAGCC TGCTAGAATG TCACATGGAT GGCTGTCATA 5280

GGGGTTGTAC ATATCCTTTT TTGTTCCTTT TTCCTGCTGC CATACTGTAT GCAGTACTGC 5340 0 AAGCTAATAA CGTTGGTTTG TTATGTAGTG TGCTTTTTGT CCCTTTCCTT CTATCACCCT 5400

ACATTCCAGC ATCTTACCTT CATATGCAGT AAAAGAAAGA AAGAAAAAAA AAGGAAAAAA 5460

AAAAAAAAAC CAATGTTTTG CAGTTTTTTT CATTGCCAAA AACTAAATGG TGCTTTATAT 5520

TTAGATTGGA AAGAATTTCA TATGCAAAGC ATATTAAAGA GAAAGCCCGC TTTAGTCAAT 5580

ACTTTTTTGT AAATGGCAAT GCAGAATATT TTGTTATTGG CCTTTTCTAT TCCTGTAATG 5640 5 AAAGCTGTTT GTCGTAACTT GAAATTTTAT CTTTTACTAT GGGAGTCACT ATTTATTATT 5700

GCTTATGTGC CCTGTTCAAA ACAGAGGCAC TTAATTTGAT CTTTTATTTT TCTTTGTTTT 5760

TATTTTTTTT TTTATTTAGA TGACCAAAGG TCATTACAAC CTGGCTTTTT ATTGTATTTG 5820

TTTCTGGTCT TTGTTAAGTT CTATTGGAAA AACCACTGTC TGTGTTTTTT TGGCAGTTGT 5880

CTGCATTAAC CTGTTCATAC ACCCATTTTG TCCCTTTATT GAAAAAATAA AAAAAATTAA 5940 0 A

Seq ID NO: 85 Protein sequence: Protein Accession #: NP 075044.1 5 11 21 31 41 51

I I I I I I

MSRRKQGKPQ HLSKREFSPE PLEAILTDDE PDHGPLGAPE GDHDLLTCGQ CQMNPPLGDI 60

LIFIEHKRKQ CNGSLCLEKA VDKPPSPSPI EMKKASNPVE VGIQVTPEDD DCLSTSSRRI 120

CPKQEHIADK LLHWRGLSSP RSAHGALIPT PGMSAEYAPQ GICKDEPSSY TCTTCKQPFT 180 0 SAWFLLQHAQ NTHGLRIYLE SEHGSPLTPR VGIPSGLGAE CPSQPPLHGI HIADNNPFNL 240

LRIPGSVSRE ASGLAEGRFP PTPPLFSPPP RHHLDPHRIE RLGAEEMALA THHPSAFDRV 300

LRLNPMAMEP PAMDFSRRLR ELAGNTSSPP LSPGRPSPMQ RLLQPFQPGS KPPFLATPPL 360

PPLQSAPPPS QPPVKSKSCE FCGKTFKFQS NLWHRRSHT GEKPYKCNLC DHACTQASKL 420

. KRHMKTHMHK SSPMTVKSDD GLSTASSPEP GTSDLVGSAS SALKSWAKF KSENDPNLIP 480 5 ENGDEEEEED DEEEEEEEEE EEEELTESER VDYGFGLSLE AARHHENSSR GAWGVGDES 540

RALPDVMQGM VLSSMQHFSE AFHQVLGEKH KRGHLAEAEG HRDTCDEDSV AGESDRIDDG 600

TVNGRGCSPG ESASGGLSKK LLLGSPSSLS PFSKRIKLEK EFDLPPATMP NTENVYSQWL 660

AGYAASRQLK DPFLSFGDSR QSPFASSSEH SSENGSLRFS TPPGELDGGI SGRSGTGSGG 720

STPHISGPGT GRPSSKEGRR SDTCEYCGKV FKNCSNLTVH RRSHTGERPY KCELCNYACA 780 0 QSSKLTRHMK THGQVGKDVY KCEICKMPFS VYSTLEKHMK KWHSDRVLNN DIKTE

Seq ID NO: 86 DNA sequence Nucleic Acid Accession #: XM_035292.2 /5 Coding sequence: 53-1576

1 11 21 31 41 51

I I I I I I

GCTCGCTGGG CCGCGGCTCC CGGGTGTCCC AGGCCCGGCC GGTGCGCAGA GCATGGCGGG 60 0 TGCGGGCCCG AAGCGGCGCG CGCTAGCGGC GCCGGCGGCC GAGGAGAAGG AAGAGGCGCG 120

GGAGAAGATG CTGGCCGCCA AGAGCGCGGA CGGCTCGGCG CCGGCAGGCG AGGGCGAGGG 180

CGTGACCCTG CAGCGGAACA TCACGCTGCT CAACGGCGTG GCCATCATCG TGGGGACCAT 240

TATCGGCTCG GGCATCTTCG TGACGCCCAC GGGCGTGCTC AAGGAGGCAG GCTCGCCGGG 300 _ GCTGGCGCTG GTGGTGTGGG CCGCGTGCGG CGTCTTCTCC ATCGTGGGCβ CGCTCTGCTA 360 5 CGCGGAGCTC GGCACCACCA TCTCCAAATC GGGCGGCGAC TACGCCTACA TGCTGGAGGT 420

CTACGGCTCG CTGCCCGCCT TCCTCAAGCT CTGGATCGAG CTGCTCATCA TCCGGCCTTC 480

ATCGCAGTAC ATCGTGGCCC TGGTCTTCGC CACCTACCTG CTCAAGCCGC TCTTCCCCAC 540 CTGCCCGGTG CCCGAGGAGG CAGCCAAGCT CGTGGCCTGC CTCTGCGTGC TGCTGCTCAC 600 GGCCGTGAAC TGCTACAGCG TGAAGGCCGC CACCCGGGTC CAGGATGCCT TTGCCGCCGC 660 CAAGCTCCTG GCCCTGGCCC TGATCATCCT GCTGGGCTTC GTCCAGATCG GGAAGGGTGA 720 TGTGTCCAAT CTAGATCCCA ACTTCTCATT TGAAGGCACC AAACTGGATG TGGGGAACAT 780 TGTGCTGGCA TTATACAGCG GCCTCTTTGC CTATGGAGGA TGGAATTACT TGAATTTCGT 840 CACAGAGGAA ATGATCAACC CCTACAGAAA CCTGCCCCTG GCCATCATCA TCTCCCTGCC 900 CATCGTGACG CTGGTGTACG TGCTGACCAA CCTGGCCTAC TTCACCACCC TGTCCACCGA 960 GCAGATGCTG TCGTCCGAGG CCGTGGCCGT GGACTTCGGG AACTATCACC TGGGCGTCAT 1020 GTCCTGGATC ATCCCCGTCT TCGTGGGCCT GTCCTGCTTC GGCTCCGTCA ATGGGTCCCT 1080 GTTCACATCC TCCAGGCTCT TCTTCGTGGG GTCCCGGGAA GGCCACCTGC CCTCCATCCT 1140 CTCCATGATC CACCCACAGC TCCTCACCCC CGTGCCGTCC CTCGTGTTCA CGTGTGTGAT 1200 GACGCTGCTC TACGCCTTCT CCAAGGACAT CTTCTCCGTC ATCAACTTCT TCAGCTTCTT 1260 CAACTGGCTC TGCGTGGCCC TGGCCATCAT CGGCATGATC TGGCTGCGCC ACAGAAAGCC 1320 TGAGCTTGAG CGGCCCATCA AGGTGAACCT GGCCCTGCCT GTGTTCTTCA TCCTGGCCTG 1380 CCTCTTCCTG ATCGCCGTCT CCTTCTGGAA GACACCCGTG GAGTGTGGCA TCGGCTTCAC 1440 CATCATCCTC AGCGGGCTGC CCGTCTACTT CTTCGGGGTC TGGTGGAAAA ACAAGCCCAA 1500 GTGGCTCCTC CAGGGCATCT TCTCCACGAC CGTCCTGTGT CAGAAGCTCA TGCAGGTGGT 1560 CCCCCAGGAG ACATAGCCAG GAGGCCGAGT GGCTGCCGGA GGAGCATGC

Seq ID NO: 87 Protein sequence: Protein Accession #: XP 035292.2

11 21 31 41 51

I

MAGAGPKRRA LAAPAAEEKE EAREKMLAAK SADGSAPAGE G IEGVTLQRNI T ILLNGVAIIV 60 GTIIGSGIFV TPTGVLKEAG SPGLALWWA ACGVFSIVGA LCYAELGTTI SKSGGDYAYM 120 LEVYGSLPAF LKLWIELLII RPSSQYIVAL VFATYLLKPL FPTCPVPEEA AKLVACLCVL 180 LLTAVNCYSV KAATRVQDAF AAAKLLALAL IILLGFVQIG KGDVSNLDPN FSFEGTKLDV 240 GNIVLALYSG LFAYGGWNYL NFVTEEMINP YRNLPLAIII SLPIVTLVYV LTNLAYFTTL 300 STEQMLSSEA VAVDFGNYHL GVMSWIIPVF VGLSCFGSVN GSLFTSSRLF FVGSREGHLP 360 SILSMIHPQL LTPVPSLVFT CVMTLLYAFS KDIFSVINFF SFFNWLCVAL AIIGMIWLRH 420 RKPELERPIK VNLALPVFFI LACLFLIAVS FWKTPVECGI GFTIILSGLP VYFFGVWWKN 480 KPKWLLQGIF STTVLCQKLM QWPQET

Seq ID NO: 88 DNA sequence

Nucleic Acid Accession #: NM_005268.1

Coding sequence: 168-989

11 21 31

TAAAAAGCAA AAGAATTCGC GGCCGCGTCG ACACGGGCTT CCCCGAAAAC CTTCCCCGCT 60

TCTGGATATG AAATTCAAGC TGCTTGCTGA GTCCTATTGC CGGCTGCTGG GAGCCAGGAG 120

AGCCCTGAGG AGTAGTCACT CAGTAGCAGC TGACGCGTGG GTCCACCATG AACTGGAGTA 180

TCTTTGAGGG ACTCCTGAGT GGGGTCAACA AGTACTCCAC AGCCTTTGGG CGCATCTGGC 240

TGTCTCTGGT CTTCATCTTC CGCGTGCTGG TGTACCTGGT GACGGCCGAG CGTGTGTGGA 300

GTGATGACCA CAAGGACTTC GACTGCAATA CTCGCCAGCC CGGCTGCTCC AACGTCTGCT 360

TTGATGAGTT CTTCCCTGTG TCCCATGTGC GCCTCTGGGC CCTGCAGCTT ATCCTGGTGA 420

CATGCCCCTC ACTGCTCGTG GTCATGCACG TGGCCTACCG GGAGGTTCAG GAGAAGAGGC 480

ACCGAGAAGC CCATGGGGAG AACAGTGGGC GCCTCTACCT GAACCCCGGC AAGAAGCGGG 540

GTGGGCTCTG GTGGACATAT GTCTGCAGCC TAGTGTTCAA GGCGAGCGTG GACATCGCCT 600

TTCTCTATGT GTTCCACTCA TTCTACCCCA AATATATCCT CCCTCCTGTG GTCAAGTGCC 660

ACGCAGATCC ATGTCCCAAT ATAGTGGACT GCTTCATCTC CAAGCCCTCA GAGAAGAACA 720

TTTTCACCCT CTTCATGGTG GCCACAGCTG CCATCTGCAT CCTGCTCAAC CTCGTGGAGC 780

TCATCTACCT GGTGAGCAAG AGATGCCACG AGTGCCTGGC AGCAAGGAAA GCTCAAGCCA 840

TGTGCACAGG TCATCACCCC CACGGTACCA CCTCTTCCTG CAAACAAGAC GACCTCCTTT 900

CGGGTGACCT CATCTTTCTG GGCTCAGACA GTCATCCTCC TCTCTTACCA GACCGCCCCC 960

GAGACCATGT GAAGAAAACC ATCTTGTGAG GGGCTGCCTG GACTGGTCTG GCAGGTTGGG 1020

CCTGGATGGG GAGGCTCTAG CATCTCTCAT AGGTGCAACC TGAGAGTGGG GGAGCTAAGC 1080

CATGAGGTAG GGGCAGGCAA GAGAGAGGAT TCAGACGCTC TGGGAGCCAG TTCCTAGTCC 1140

TCAACTCCAG CCACCTGCCC CAGCTCGACG GCACTGGGCC AGTTCCCCCT CTGCTCTGCA 1200

GCTCGGTTTC CTTTTCTAGA ATGGAAATAG TGAGGGCCAA TGC

Seq ID NO: 89 Protein sequence: Protein Accession #: NP 005259.1

11 21 31 41 51

MNWSIFEGLL SGVNKYSTAF GRIWLSLVFI FRVLVYLVTA ERVWSDDHKD F IDCNTRQPGC 60

SNVCFDEFFP VSHVRLWALQ LILVTCPSLL WMHVAYREV QEKRHREAHG ENSGRLYLNP 120

GKKRGGL WT YVCSLVFKAS VDIAFLYVFH SFYPKYILPP WKCHADPCP NIVDCFISKP 180

SEKNIFTLFM VATAAICILL NLVELIYLVS KRCHECLAAR KAQAMCTGHH PHGTTSSCKQ • 240 DDLLSGDLIF LGSDSHPPLL PDRPRDHVKK TIL

Seq ID NO: 90 DNA sequence

Nucleic Acid Accession #: NM_002391.1

Coding sequence: 26-457

11 21 31 41 51

CGGGCGAAGC AGCGCGGGCA GCGAGATGCA GCACCGAGGC TTCCTCCTCC TCACCCTCCT 60 CGCCCTGCTG GCGCTCACCT CCGCGGTCGC CAAAAAGAAA GATAAGGTGA AGAAGGGCGG 120 CCCGGGGAGC GAGTGCGCTG AGTGGGCCTG GGGGCCCTGC ACCCCCAGCA GCAAGGATTG 180 CGGCGTGGGT TTCCGCGAGG GCACCTGCGG GGCCCAGACC CAGCGCATCC GGTGCAGGGT 240 GCCCTGCAAC TGGAAGAAGG AGTTTGGAGC CGACTGCAAG TACAAGTTTG AGAACTGGGG 300 TGCGTGTGAT GGGGGCACAG GCACCAAAGT CCGCCAAGGC ACCCTGAAGA AGGCGCGCTA 360 CAATGCTCAG TGCCAGGAGA CCATCCGCGT CACCAAGCCC TGCACCCCCA AGACCAAAGC 420

AAAGGCCAAA GCCAAGAAAG GGAAGGGAAA GGACTAGACG CCAAGCCTGG ATGCCAAGGA 480

GCCCCTGGTG TCACATGGGG CCTGGCCACG CCCTCCCTCT CCCAGGCCCG AGATGTGACC 540

CACCAGTGCC TTCTGTCTGC TCGTTAGCTT TAATCAATCA TGCCCTGCCT TGTCCCTCTC 600

ACTCCCCAGC CCCACCCCTA AGTGCCCAAA GTGGGGAGGG ACAAGGGATT CTGGGAAGCT 660

TGAGCCTCCC CCAAAGCAAT GTGAGTCCCA GAGCCCGCTT TTGTTCTTCC CCACAATTCC 720

ATTACTAAGA AACACATCAA ATAAACTGAC TTTTTCCCCC CAATAAAAGC TCTTCTTTTT 780 TAATAT

Seq ID NO : 91 Protein sequence : Protein Accession # : NP 002382 . 1

1 11 21 31 41 51

I I I I I I

MQHRGFLLLT LLALLALTSA VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT 60 CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI 120 RVTKPCTPKT KAKAKAKKGK GKD Seq ID NO: 92 DNA sequence

Nucleic Acid Accession #: NM_005130.1 Coding sequence: 98-802

11 21 31 41 51

1 I I I I

CTCTACCTGA CACAGCTGCA GCCTGCAATT CACTCCCACT GCCTGGGATT GCACTGGATC 60 CGTGTGCTCA GAACAAGGTG AACGCCCAGC TGCAGCCATG AAGATCTGTA GCCTCACCCT 120 GCTCTCCTTC CTCCTACTGG CTGCTCAGGT GCTCCTGGTG GAGGGGAAAA AAAAAGTGAA 180 GAATGGACTT CACAGCAAAG TGGTCTCAGA ACAAAAGGAC ACTCTGGGCA ACACCCAGAT 240 TAAGCAGAAA AGCAGGCCCG GGAACAAAGG CAAGTTTGTC ACCAAAGACC AAGCCAACTG 300 CAGATGGGCT GCTACTGAGC AGGAGGAGGG CATCTCTCTC AAGGTTGAGT GCACTCAATT 360 GGACCATGAA TTTTCCTGTG TCTTTGCTGG CAATCCAACC TCATGCCTAA AGCTCAAGGA 420 TGAGAGAGTC TATTGGAAAC AAGTTGCCCG GAATCTGCGC TCACAGAAAG ACATCTGTAG 480 ATATTCCAAG ACAGCTGTGA AAACCAGAGT GTGCAGAAAG GATTTTCCAG AATCCAGTCT 540 TAAGCTAGTC AGCTCCACTC TATTTGGGAA CACAAAGCCC AGGAAGGAGA AAACAGAGAT 600 GTCCCCCAGG GAGCACATCA AGGGCAAAGA GACCACCCCC TCTAGCCTAG CAGTGACCCA 660 GACCATGGCC ACCAAAGCTC CCGAGTGTGT GGAGGACCCA GATATGGCAA ACCAGAGGAA 720 GACTGCCCTG GAGTTCTGTG GAGAGACTTG GAGCTCTCTC TGCACATTCT TCCTCAGCAT 780 AGTGCAGGAC ACGTCATGCT AATGAGGTCA AAAGAGAACG GGTTCCTTTA AGAGATGTCA 840 TGTCGTAAGT CCCTCTGTAT ACTTTAAAGC TCTCTACAGT CCCCCCAAAA TATGAACTTT 900 TGTGCTTAGT GAGTGCAACG AAATATTTAA ACAAGTTTTG TATTTTTTGC TTTTGTGTTT 960 TGGAATTTGC CTTATTTTTC TTGGATGCGA TGTTCAGAGG CTGTTTCCTG CAGCATGTAT 1020 TTCCATGGCC CACACAGCTA TGTGTTTGAG CAGCGAAGAG TCTTTGAGCT GAATGAGCCA 1080 GAGTGATAAT TTCAGTGCAA CGAACTTTCT GCTGAATTAA TGGTAATAAA ACTCTGGGTG 1140 TTTTTCAAAA AAAAAAAAAA AAA

Seq ID NO: 93 Protein sequence: Protein Accession #: NP 005121.1

11 21 31 41 51

MKICSLTLLS FLLLAAQVLL VEGKKKVKNG LHSKWSEQK DTLGNTQIKQ KSRPGNKGKF 60

VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNP TSCLKLKDER VYWKQVARNL 120

RSQKDICRYS KTAVKTRVCR KDFPESSLKL VSSTLFGNTK PRKEKTEMSP REHIKGKETT 180 PSSLAVTQTM ATKAPECVED PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC

Seq ID NO: 94 DNA sequence

Nucleic Acid Accession #: NM_012101

Coding sequence: 125-1891

11 21 31 41 51

I I I I

CTCCTCACAG GTGTGTCTCT AGTCCTCGTG GTTGCCTGCC CCACTCCCTG CCGAGACGCC 60 TGCCAGAAAG GTCACCTATC CTGAACCCCA GCAAGCCTGA AACAGCTCAG CCAAGCACCC 120 TGCGATGGAA GCTGCAGATG CCTCCAGGAG CAACGGGTCG AGCCCAGAAG CCAGGGATGC 180 CCGGAGCCCG TCGGGCCCCA GTGGCAGCCT GGAGAATGGC ACCAAGGCTG ACGGCAAGGA 240 TGCCAAGACC ACCAACGGGC ACGGCGGGGA GGCAGCTGAG GGCAAGAGCC TGGGCAGCGC 300 CCTGAAGCCA GGGGAAGGTA GGAGCGCCCT GTTCGCGGGC AATGAGTGGC GGCGACCCAT 360 CATCCAGTTT GTCGAGTCCG GGGACGACAA GAACTCCAAC TACTTCAGCA TGGACTCTAT 420 GGAAGGCAAG AGGTCGCCGT ACGCAGGGCT CCAGCTGGGG GCTGCCAAGA AGCCACCCGT 480 TACCTTTGCC GAAAAGGGCG ACGTGCGCAA GTCCATTTTC TCGGAGTCCC GGAAGCCCAC 540 GGTGTCCATC ATGGAGCCCG GGGAGACCCG GCGGAACAGC TACCCCCGGG CCGACACGGG 600 CCTTTTTTCA CGGTCCAAGT CCGGCTCCGA GGAGGTGCTG TGCGACTCCT GCATCGGCAA 660 CAAGCAGAAG GCGGTCAAGT CCTGCCTGGT GTGCCAGGCC TCCTTCTGCG AGCTGCATCT 720 CAAGCCCCAC CTGGAGGGCG CCGCCTTCCG AGACCACCAG CTGCTCGAGC CCATCCGGGA 780 CTTTGAGGCC CGCAAGTGTC CCGTGCATGG CAAGACGATG GAGCTCTTCT GCCAGACCGA 840 CCAGACCTGC ATCTGCTACC TTTGCATGTT CCAGGAGCAC AAGAATCATA GCACCGTGAC 900 AGTGGAGGAG GCCAAGGCCG AGAAGGAGAC GGAGCTGTCA CTGCAAAAGG AGCAGCTGCA 960 GCTCAAGATC ATTGAGATTG AGGATGAAGC TGAGAAGTGG CAGAAGGAGA AGGACCGCAT 1020 CAAGAGCTTC ACCACCAATG AGAAGGCCAT CCTGGAGCAG AACTTCCGGG ACCTGGTGCG 1080 GGACCTGGAG AAGCAAAAGG AGGAAGTGAG GGCTGCGCTG GAGCAGCGGG AGCAGGATGC 1140 TGTGGACCAA GTGAAGGTGA TCATGGATGC TCTGGATGAG AGAGCCAAGG TGCTGCATGA 1200 GGACAAGCAG ACCCGGGAGC AGCTGCATAG CATCAGCGAC TCTGTGTTGT TTCTGCAGGA 1260 ATTTGGTGCA TTGATGAGCA ATTACTCTCT CCCCCCACCC CTGCCCACCT ATCATGTCCT 1320 GCTGGAGGGG GAGGGCCTGG GACAGTCACT AGGCAACTTC AAGGACGACC TGCTCAATGT 1380 ATGCATGCGC CACGTTGAGA AGATGTGCAA GGCGGACCTG AGCCGTAACT TCATTGAGAG 1440 GAACCACATG GAGAACGGTG GTGACCATCG CTATGTGAAC AACTACACGA ACAGCTTCGG 1500 GGGTGAGTGG AGTGCACCGG ACACCATGAA GAGATACTCC ATGTACCTGA CACCCAAAGG 1560

TGGGGTCCGG ACATCATACC AGCCCTCGTC TCCTGGCCGC TTCACCAAGG AGACCACCCA 1620

GAAGAATTTC AACAATCTCT ATGGCACCAA AGGTAACTAC ACCTCCCGGG TCTGGGAGTA 1680

CTCCTCCAGC ATTCAGAACT CTGACAATGA CCTGCCCGTC GTCCAAGGCA GCTCCTCCTT 1740

CTCCCTGAAA GGCTATCCCT CCCTCATGCG GAGCCAAAGC CCCAAGGCCC AGCCCCAGAC 1800

TTGGAAATCT GGCAAGCAGA CTATGCTGTC TCACTACCGG CCATTCTACG TCAACAAAGG 1860

CAACGGGATT GGGTCCAACG AAGCCCCATG AGCTCCTGGC GGAAGGAACG AGGCGCCACA 1920

CCCCTGCTCT TCCTCCTGAC CCTGCTGCTC TTGCCTTCTA AGCTACTGTG CTTGTCTGGG 1980

TGGGAGGGAG CCTGGTCCTG CACCTGCCCT CTGCAGCCCT CTGCCAGCCT CTTGGGGGCA 2040

GTTCCGGCCT CTCCGACTTC CCCACTGGCC ACACTCCATT CAGACTCCTT TCCTGCCTTG 2100

TGACCTCAGA TGGTCACCAT CATTCCTGTG CTCAGAGGCC AACCCATCAC AGGGGTGAGA 2160

TAGGTTGGGG CCTGCCCTAA CCCGCCAGCC TCCTCCTCTC GGGCTGGATC TGGGGGCTAG 2220

CAGTGAGTAC CCGCATGGTA TCAGCCTGCC TCTCCCGCCC ACGCCCTGCT GTCTCCAGGC 2280

CTATAGACGT TTCTCTCCAA GGCCCTATCC CCCAATGTTG TCAGCAGATG CCTGGACAGC 2340

ACAGCCACCC ATCTCCCATT CACATGGCCC ACCTCCTGCT TCCCAGAGGA CTGGCCCTAC 2400

GTGCTCTCTC TCGTCCTACC TATCAATGCC CAGCATGGCA GAACCTGCAG TGGCCAAGGG 2460

CTGCAGATGG AAACCTCTCA GTGTCTTGAC ATCACCCTAC CCAGGCGGTG GGTCTCCACC 2520

ACAGCCACTT TGAGTCTGTG GTCCCTGGAG GGTGGCTTCT CCTGACTGGC AGGATGACCT 2580

TAGCCAAGAT ATTCCTCTGT TCCCTCTGCT GAGATAAAGA ATTCCCTTAA CATGATATAA 2640

TCCACCCATG CAAATAGCTA CTGGCCCAGC TACCATTTAC CATTTGCCTA CAGAATTTCA 2700

TTCAGTCTAC ACTTTGGCAT TCTCTCTGGC GATGGAGTGT GGCTGGGCTG ACCGCAAAAG 2760

GTGCCTTACA CACTGCCCCC ACCCTCAGCC GTTGCCCCAT CAGAGGCTGC CTCCTCCTTC 2820

TGATTACCCC CCATGTTGCA TATCAGGGTG CTCAAGGATT GGAGAGGAGA CAAAACCAGG 2880

AGCAGCACAG TGGGGACATC TCCCGTCTCA ACAGCCCCAG GCCTATGGGG GCTCTGGAAG 2940

GATGGGCCAG CTTGCAGGGG TTGGGGAGGG AGACATCCAG CTTGGGCTTT CCCCTTTGGA 3000 ATAAACCATT GGTCTGTC

Seq ID NO: 95 Protein sequence: Protein Accession #: NP_036233.1

11 21 31 41 51

MEAADASRSN GSSPEARDAR SPSGPSGSLE NGTKADGKDA KTTNGHGGEA AEGKSLGSAL 60 KPGEGRSALF AGNEWRRPII QFVESGDDKN SNYFSMDSME GKRSPYAGLQ LGAAKKPPVT 120 FAEKGDVRKS IFSESRKPTV SIMEPGETRR NSYPRADTGL FSRSKSGSEE VLCDSCIGNK 180 QKAVKSCLVC QASFCELHLK PHLEGAAFRD HQLLEPIRDF EARKCPVHGK TMELFCQTDQ 240 TCICYLCMFQ EHKNHSTVTV EEAKAEKETE LSLQKEQLQL KIIEIEDEAE KWQKEKDRIK 300 SFTTNEKAIL EQNFRDLVRD LEKQKEEVRA ALEQREQDAV DQVKVIMDAL DERAKVLHED 360 KQTREQLHSI SDSVLFLQEF GALMSNYSLP PPLPTYHVLL EGEGLGQSLG NFKDDLLNVC 420 MRHVEKMCKA DLSRNFIERN HMENGGDHRY VNNYTNSFGG EWSAPDTMKR YSMYLTPKGG 480 VRTSYQPSSP GRFTKETTQK NFNNLYGTKG NYTSRVWEYS SSIQNSDNDL PWQGSSSFS 540 LKGYPSLMRS QSPKAQPQTW KSGKQTMLSH YRPFYVNKGN GIGSNEAP

Seq ID NO: 96 DNA sequence

Nucleic Acid Accession #-. NM_080668.1

Coding sequence: 83-841

11 21 31 41 51

GGCACGAGGG C IAGCGAGTGG C ICTTCCCGGT T IGGCGCGCGC C 1CGGGGCGGC GGCGCTGGAG 60 GAGCTCGAGA CGGAGCCTAG TTATGTCTGG GAGGCGAACG CGGTCCGGAG GAGCCGCTCA 120 GCGCTCCGGG CCAAGGGCCC CATCTCCTAC TAAGCCTCTG CGGAGGTCCC AGCGGAAATC 180 AGGCTCTGAA CTCCCGAGCA TCCTCCCTGA AATCTGGCCG AAGACACCCA GTGCGGCTGC 240 AGTCAGAAAG CCCATCGTCT TAAAGAGGAT CGTGGCCCAT GCTGTAGAGG TCCCAGCTGT 300 CCAATCACCT CGCAGGAGCC CTAGGATTTC CTTTTTCTTG GAGAAAGAAA ACGAGCCCCC 360 TGGCAGGGAG CTTACTAAGG AGGACCTTTT CAAGACACAC AGCGTCCCTG CCACCCCCAC 420 CAGCACTCCT GTGCCGAACC CTGAGGCCGA GTCCAGCTCC AAGGAAGGAG AGCTGGACGC 480 CAGAGACTTG GAAATGTCTA AGAAAGTCAG GCGTTCCTAC AGCCGGCTGG AGACCCTGGG 540 CTCTGCCTCT ACCTCCACCC CAGGCCGCCG GTCCTGCTTT GGCTTCGAGG GGCTGCTGGG 600 GGCAGAAGAC TTGTCCGGAG TCTCGCCAGT GGTGTGCTCC AAACTCACCG AGGTCCCCAG 660 GGTTTGTGCA AAGCCCTGGG CCCCAGACAT GACTCTCCCT GGAATCTCCC CACCACCCGA 720 GAAACAGAAA CGTAAGAAGA AGAAAATGCC AGAGATCTTG AAAACGGAGC TGGATGAGTG 780 GGCTGCGGCC ATGAATGCCG AGTTTGAAGC TGCTGAGCAG TTTGATCTCC TGGTTGAATG 840 AGATGCAGTG GGGGGTGCAC CTGGCCAGAC TCTCCCTCCT GTCCTGTACA TAGCCACCTC 900 CCTGTGGAGA GGACACTTAG GGTCCCCTCC CCTGGTCTTG TTACCTGTGT GTGTGCTGGT 960 GCTGCGCATG AGGACTGTCT GCCTTTGAGG GCTTGGGCAG CAGCGGCAGC CATCTTGGTT 1020 TTAGGAAATG GGGCCGCCTG GCCCAGCCAC TCACTGGTGT CCTGTCTCTT GTCGTCCTGT 1080 ' CCTTCCTATC TCCCCAAAGT ACCATAGCCA GTTTCCAGAT GGGCCACAGA CTGGGGAGGA 1140 GAATCAGTGG CCCAGCCAGA AGTTAAAGGG CTGAGGGTTG AGGTGAGAGG CACCTCTGCT 1200 CTTGTTGGGA GGGGTGGCTG CTTGGAAATA GGCCCAGGGG CTCTGCCAGC CTCGGCCTCT 1260 CCCTCCTGAG TTGCCTTCTG TTGGTGGCTT TCTTCTTGAA CCCACCTGTG TAAAGAGGTT 1320 TTCAGTTCCG TGGGTTTCCC CTTTGATTCT GTAAATAGTC CCAGAGAGAA TTCGTGGGCT 1380 GAGGGCAATT CTGTCTTGGA GGAAGAAGCT GGACATTCAG CCTGTGGAGT CTGAGTTTTG 1440 AAGGATGTAG GGAGCCTTAG TTGGGTCTCA GACCATAAGT GTGTACTACA CAGAAGCTGT 1500 GTTTTCTAGT TCTGGTCTGC TGTTGAGATG TTTGGTAAAT GCCAGGTTGA TAGGGCGCTG 1560 GCTGCTTGGA GCAAAGGGTG CATTTCAGGG TGTGGCCACC AGGTGCTGTG AGTTTCTGTG 1620 GCTCATGGCC TCTGGGCTGG TCCCTTGCAC AGGGCCCACG CTGGAGTCTT ACCACTCTGC 1680 TGCAGGGGTG GAAGGTGGCC CCTCTTGTCA CCCATACCCA TTTCTTACAA AATAAGTTAC 1740 ACCGAGTCTA CTTGGCCCTA GAAGAGAAAG TTGAAGAGTC CCAGACCTAC TAGCATTTTG 1800 CAACTATGCT TGTAAAGTCC TCGGAAAGTT TCCTCGCGTA CCAGACAGCG GCGGGGGCTG 1860 ATAGCAATTT TAGTTTTTGG CCTCCCTATC CTCTCACATG AGAACACTGC CTGGATGCAT 1920 CTCATGATCT CTGGAGAATT TCCCCATCTT TCTCTTCTTT CCATCGTGTG GATTCAATAG 1980 TTTGGATTTG AAGGCTGCCC TGCCCCCGAC TCTCCTGCCG CACCCCTGGC CATTGTACCT 2040 TTTGATGTTT AGAAGTTCGT GGAAGTAGAC GCTGAGGTGT GCAGAGGAGC TGGTGGATAA 2100 CAGAGAATGC CAGGGAAGAT GAGTGCTGGG TCAGGGTACT TGGATGAAAC GGTGCAGGCC 2160 AGGCGGGCCC TAATAAAACC CTCTGCCAGG TCTGGGAGTC CCAGGCCATC TGCTCAACGC 2220 TCTGTGGTTT GTCAGACCTG CAAGCAAGCC CCCTGCTGGG GAAGCCTAGG TGTCCTTGAG 2280

CTGAACCGCA CTGAAGAACT CTTGTCCTCA CTGGCTGATG CAGCAGAACT CTTGGGAAAT 2340

GTCTTAGTCC TGCAGAATCA GGAGTCACCA GATGATGCAG AGTTGAGATC ATCATTGCAA 2400

AGTTCTCTGT TCCTGAGGAA CTAAATTTAA GGAAAAAATG GGATTTTGTT TTAGAGTTGG 2460 AAAAAAAGCC TGATTAAAGA GTTTCTGCCT GTTAAAAAAA AAAAAAAAAA AAAAAA

Seq ID NO: 97 Protein sequence: Protein Accession #: NP_542399.1

1 11 21 31 41 51

I I I I I I

MSGRRTRSGG AAQRSGPRAP SPTKPLRRSQ RKSGSELPSI LPEIWPKTPS AAAVRKPIVL 60

KRIVAHAVEV PAVQSPRRSP RISFFLEKEN EPPGRELTKE DLFKTHSVPA TPTSTPVPNP 120

EAESSSKEGE LDARDLEMSK KVRRSYSRLE TLGSASTSTP GRRSCFGFEG LLGAEDLSGV 180

SPWCSKLTE VPRVCAKPWA PDMTLPGISP PPEKQKRKKK KMPEILKTEL DEWAAAMNAE 240 FEAAEQFDLL VE

Seq ID NO: 98 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 58-12444

1 11 21 31 41 51

I I I I I I

GGGGCATTTC CGGGTCCGGG CCGAGCGGGC GCACGCGCGG GAGCGGGACT CGGCGGCATG 60

GCGGGCTCCG GAGCCGGTGT GCGTTGCTCC CTGCTGCGGC TGCAGGAGAC CTTGTCCGCT 120

GCGGACCGCT GCGGTGCTGC CCTGGCCGGT CATCAACTGA TCCGCGGCCT GGGGCAGGAA 180

TGCGTCCTGA GCAGCAGCCC CGCGGTGCTG GCATTACAGA CATCTTTAGT TTTTTCCAGA 240

GATTTCGGTT TGCTTGTATT TGTCCGGAAG TCACTCAACA GTATTGAATT TCGTGAATGT 300

AGAGAAGAAA TCCTAAAGTT TTTATGTATT TTCTTAGAAA AAATGGGCCA GAAGATCGCA 60

CCTTACTCTG TTGAAATTAA GAACACTTGT ACCAGTGTTT ATACAAAAGA TAGAGCTGCT 420

AAATGTAAAA TTCCAGCCCT GGACCTTCTT ATTAAGTTAC TTCAGACTTT TAGAAGTTCT 480

AGACTCATGG ATGAATTTAA AATTGGAGAA TTATTTAGTA AATTCTATGG AGAACTTGCA 540

TTGAAAAAAA AAATACCAGA TACAGTTTTA GAAAAAGTAT ATGAGCTCCT AGGATTATTG 600

GGTGAAGTTC ATCCTAGTGA GATGATAAAT AATGCAGAAA AGCTGTTCCG CGCTTTTCTG 660

GGTGAACTTA AGACCCAGAT GACATCAGCA GTAAGAGAGC CCAAACTACC TGTTCTGGCA 720

GGATGTCTGA AGGGGTTGTC CTCACTTCTG TGCAACTTCA CTAAGTCCAT GGAAGAAGAT 780

CCCCAGACTT CAAGGGAGAT TTTTAATTTT GTACTAAAGG CAATTCGTCC TCAGATTGAT 840

CTGAAGAGAT ATGCTGTGCC CTCAGCTGGC TTGCGCCTAT TTGCCCTGCA TGCATCTCAG 900

TTTAGCACCT GCCTTCTGGA CAACTACGTG TCTCTATTTG AAGTCTTGTT AAAGTGGTGT 960

GCCCACACAA ATGTAGAATT GAAAAAAGCT GCACTTTCAG CCCTGGAATC CTTTCTGAAA 1020

CAGGTTTCTA ATATGGTGGC GAAAAATGCA GAAATGCATA AAAATAAACT GCAGTACTTT 1080

ATGGAGCAGT TTTATGGAAT CATCAGAAAT GTGGATTCGA ACAACAAGGA GTTATCTATT 1140

GCTATCCGTG GATATGGACT TTTTGCAGGA CCGTGCAAGG TTATAAACGC AAAAGATGTT 1200

GACTTCATGT ACGTTGAGCT CATTCAGCGC TGCAAGCAGA TGTTCCTCAC CCAGACAGAC 1260

ACTGGTGACG ACCGTGTTTA TCAGATGCCA AGCTTCCTCC AGTCTGTTGC AAGCGTCTTG 1320

CTGTACCTTG ACACAGTTCC TGAGGTGTAT ACTCCAGTTC TGGAGCACCT CGTGGTGATG 1380

CAGATAGACA GTTTCCCACA GTACAGTCCA AAAATGCAGC TGGTGTGTTG CAGAGCCATA 1440

GTGAAGGTGT TCCTAGCTTT GGCAGCAAAA GGGCCAGTTC TCAGGAATTG CATTAGTACT 1500

GTGGTGCATC AGGGTTTAAT CAGAATATGT TCTAAACCAG TGGTCCTTCC AAAGGGCCCT 1560

GAGTCTGAAT CTGAAGACCA CCGTGCTTCA GGGGAAGTCA GAACTGGCAA ATGGAAGGTG 1620

CCCACATACA AAGACTACGT GGATCTCTTC AGACATCTCC TGAGCTCTGA CCAGATGATG 1680

GATTCTATTT TAGCAGATGA AGCATTTTTC TCTGTGAATT CCTCCAGTGA AAGTCTGAAT 1740

CATTTACTTT ATGATGAATT TGTAAAATCC GTTTTGAAGA TTGTTGAGAA ATTGGATCTT 1800

ACACTTGAAA TACAGACTGT TGGGGAACAA GAGAATGGAG ATGAGGCGCC TGGTGTTTGG 1860

ATGATCCCAA CTTCAGATCC AGCGGCTAAC TTGCATCCAG CTAAACCTAA AGATTTTTCG 1920

GCTTTCATTA ACCTGGTGGA ATTTTGCAGA GAGATTCTCC CTGAGAAACA AGCAGAATTT 1980

TTTGAACCAT GGGTGTACTC ATTTTCATAT GAATTAATTT TGCAATCTAC AAGGTTGCCC 2040

CTCATCAGTG GTTTCTACAA ATTGCTTTCT ATTACAGTAA GAAATGCCAA GAAAATAAAA 2100

TATTTCGAGG GAGTTAGTCC AAAGAGTCTG AAACACTCTC CTGAAGACCC AGAAAAGTAT 2160

TCTTGCTTTG CTTTATTTGT GAAATTTGGC AAAGAGGTGG CAGTTAAAAT GAAGCAGTAC 2220

AAAGATGAAC TTTTGGCCTC TTGTTTGACC TTTCTTCTGT CCTTGCCACA CAACATCATT 2280

GAACTCGATG TTAGAGCCTA CGTTCCTGCA CTGCAGATGG CTTTCAAACT GGGCCTGAGC 2340

TATACCCCCT TGGCAGAAGT AGGCCTGAAT GCTCTAGAAG AATGGTCAAT TTATATTGAC 2400

AGACATGTAA TGCAGCCTTA TTACAAAGAC ATTCTCCCCT GCCTGGATGG ATACCTGAAG 2460

ACTTCAGCCT TGTCAGATGA GACCAAGAAT AACTGGGAAG TGTCAGCTCT TTCTCGGGCT 2520

GCCCAGAAAG GATTTAATAA AGTGGTGTTA AAGCATCTGA AGAAGACAAA GAACCTTTCA 2580

TCAAACGAAG CAATATCCTT AGAAGAAATA AGAATTAGAG TAGTACAAAT GCTTGGATCT 2640

CTAGGAGGAC AAATAAACAA AAATCTTCTG ACAGTCACGT CCTCAGATGA GATGATGAAG 2700

AGCTATGTGG CCTGGGACAG AGAGAAGCGG CTGAGCTTTG CAGTGCCCTT TAGAGAGATG 2760

AAACCTGTCA TTTTCCTGGA TGTGTTCCTG CCTCGAGTCA CAGAATTAGC GCTCACAGCC 2820

AGTGACAGAC AAACTAAAGT TGCAGCCTGT GAACTTTTAC ATAGCATGGT TATGTTTATG 2880

TTGGGCAAAG CCACGCAGAT GCCAGAAGGG GGACAGGGAG CCCCACCCAT GTACCAGCTC 2940

TATAAGCGGA CGTTTCCTGT GCTGCTTCGA CTTGCGTGTG ATGTTGATCA GGTGACAAGG 3000

CAACTGTATG AGCCACTAGT TATGCAGCTG ATTCACTGGT TCACTAACAA CAAGAAATTT 3060

GAAAGTCAGG ATACTGTTGC CTTACTAGAA GCTATATTGG ATGGAATTGT GGACCCTGTT 3120

GACAGTACTT TAAGAGATTT TTGTGGTCGG TGTATTCGAG AATTCCTTAA ATGGTCCATT 3180

AAGCAAATAA CACCACAGCA GCAGGAGAAG AGTCCAGTAA ACACCAAATC GCTTTTCAAG 3240

CGACTTTATA GCCTTGCGCT TCACCCCAAT GCTTTCAAGA GGCTGGGAGC ATCACTTGCC 3300

TTTAATAATA TCTACAGGGA ATTCAGGGAA GAAGAGTCTC TGGTGGAACA GTTTGTGTTT 3360

GAAGCCTTGG TGATATACAT GGAGAGTCTG GCCTTAGCAC ATGCAGATGA GAAGTCCTTA 3420

GGTACAATTC AACAGTGTTG TGATGCCATT GATCACCTAT GCCGCATCAT TGAAAAGAAG 3480

CATGTTTCTT TAAATAAAGC AAAGAAACGA CGTTTGCCGC GAGGATTTCC ACCTTCCGCA 3540

TCATTGTGTT TATTGGATCT GGTCAAGTGG CTTTTAGCTC ATTGTGGGAG GCCCCAGACA 3600

GAATGTCGAC ACAAATCCAT TGAACTCTTT TATAAATTCG TTCCTTTATT GCCAGGCAAC 3660

AGATCCCCTA ATTTGTGGCT GAAAGATGTT CTCAAGGAAG AAGGTGTCTC TTTTCTCATC 3720

AACACCTTTG AGGGGGGTGG CTGTGGCCAG CCCTCGGGCA TCCTGGCCCA GCCCACCCTC 3780

TTGTACCTTC GGGGGCCATT CAGCCTGCAG GCCACGCTAT GCTGGCTGGA CCTGCTCCTG 3840 GCCGCGTTGG AGTGCTACAA CACGTTCATT GGCGAGAGAA CTGTAGGAGC GCTCCAGGTC 3900 CTAGGTACTG AAGCCCAGTC TTCACTTTTG AAAGCAGTGG CTTTCTTCTT AGAAAGCATT 3960 GCCATGCATG ACATTATAGC AGCAGAAAAG TGCTTTGGCA CTGGGGCAGC AGGTAACAGA 4020 ACAAGCCCAC AAGAGGGAGA AAGGTACAAC TACAGCAAAT GCACCGTTGT GGTCCGGATT 4080 ATGGAGTTTA CCACGACTCT GCTAAACACC TCCCCGGAAG GATGGAAGCT CCTGAAGAAG 4140 GACTTGTGTA ATACACACCT GATGAGAGTC CTGGTGCAGA CGCTGTGTGA GCCCGCAAGC 4200 ATAGGTTTCA ACATCGGAGA CGTCCAGGTT ATGGCTCATC TTCCTGATGT TTGTGTGAAT 4260 CTGATGAAAG CTCTAAAGAT GTCCCCATAC AAAGATATCC TAGAGACCCA TCTGAGAGAG 4320 AAAATAACAG CACAGAGCAT TGAGGAGCTT TGTGCCGTCA ACTTGTATGG CCCTGACGCG 4380 CAAGTGGACA GGAGCAGGCT GGCTGCTGTT GTGTCTGCCT GTAAACAGCT TCACAGAGCT 4440 GGGCTTCTGC ATAATATATT ACCGTCTCAG TCCACAGATT TGCATCATTC TGTTGGCACA 4500 GAACTTCTTT CCCTGGTTTA TAAAGGCATT GCCCCTGGAG ATGAGAGACA GTGTCTGCCT 4560 TCTCTAGACC TCAGTTGTAA GCAGCTGGCC AGCGGACTTC TGGAGTTAGC CTTTGCTTTT 4620 GGAGGACTGT GTGAGCGCCT TGTGAGTCTT CTCCTGAACC CAGCGGTGCT GTCCACGGCG 4680 TCCTTGGGCA GCTCACAGGG CAGCGTCATC CACTTCTCCC ATGGGGAGTA TTTCTATAGC 4740 TTGTTCTCAG AAACGATCAA CACGGAATTA TTGAAAAATC TGGATCTTGC TGTATTGGAG 4800 CTCATGCAGT CTTCAGTGGA TAATACCAAA ATGGTGAGTG CCGTTTTGAA CGGCATGTTA 4860 GACCAGAGCT TCAGGGAGCG AGCAAACCAG AAACACCAAG GACTGAAACT TGCGACTACA 4920 ATTCTGCAAC ACTGGAAGAA GTGTGATTCA TGGTGGGCCA AAGATTCCCC TCTCGAAACT 4980 AAAATGGCAG TGCTGGCCTT ACTGGCAAAA ATTTTACAGA TTGATTCATC TGTATCTTTT 5040 AATACAAGTC ATGGTTCATT CCCTGAAGTC TTTACAACAT ATATTAGTCT ACTTGCTGAC 5100 ACAAAGCTGG ATCTACATTT AAAGGGCCAA GCTGTCACTC TTCTTCCATT CTTCACCAGC 5160 CTCACTGGAG GCAGTCTGGA GGAACTTAGA CGTGTTCTGG AGCAGCTCAT CGTTGCTCAC 5220 TTCCCCATGC AGTCCAGGGA ATTTCCTCCA GGAACTCCGC GGTTCAATAA TTATGTGGAC 5280 TGCATGAAAA AGTTTCTAGA TGCATTGGAA TTATCTCAAA GCCCTATGTT GTTGGAATTG 5340 ATGACAGAAG TTCTTTGTCG GGAACAGCAG CATGTCATGG AAGAATTATT TCAATCCAGT 5400 TTCAGGAGGA TTGCCAGAAG GGGTTCATGT GTCACACAAG TAGGCCTTCT GGAAAGCGTG 5460 TATGAAATGT TCAGGAAGGA TGACCCCCGC CTAAGTTTCA CACGCCAGTC CTTTGTGGAC 5520 CGCTCCCTCC TCACTCTGCT GTGGCACTGT AGCCTGGATG CTTTGAGAGA ATTCTTCAGC 5580 ACAATTGTGG TGGATGCCAT TGATGTGTTG AAGTCCAGGT TTACAAAGCT AAATGAATCT 5640 ACCTTTGATA CTCAAATCAC CAAGAAGATG GGCTACTATA AGATTCTAGA CGTGATGTAT 5700 TCTCGCCTTC CCAAAGATGA TGTTCATGCT AAGGAATCAA AAATTAATCA AGTTTTCCAT 5760 GGCTCGTGTA TTACAGAAGG AAATGAACTT ACAAAGACAT TGATTAAATT GTGCTACGAT 5820 GCATTTACAG AGAACATGGC AGGAGAGAAT CAGCTGCTGG AGAGGAGAAG ACTTTACCAT 5880 TGTGCAGCAT ACAACTGCGC CATATCTGTC ATCTGCTGTG TCTTCAATGA GTTAAAATTT 5940 TACCAAGGTT TTCTGTTTAG TGAAAAACCA GAAAAGAACT TGCTTATTTT TGAAAATCTG 6000 ATCGACCTGA AGCGCCGCTA TAATTTTCCT GTAGAAGTTG AGGTTCCTAT GGAAAGAAAG 6060 AAAAAGTACA TTGAAATTAG GAAAGAAGCC AGAGAAGCAG CAAATGGGGA TTCAGATGGT 6120 CCTTCCTATA TGTCTTCCCT GTCATATTTG GCAGACAGTA CCCTGAGTGA GGAAATGAGT 6180 CAATTTGATT TCTCAACCGG AGTTCAGAGC TATTCATACA GCTCCCAAGA CCCTAGACCT 6240 GCCACTGGTC GTTTTCGGAG ACGGGAGCAG CGGGACCCCA CGGTGCATGA TGATGTGCTG 6300 GAGCTGGAGA TGGACGAGCT CAATCGGCAT GAGTGCATGG CGCCCCTGAC GGCCCTGGTC 6360 AAGCACATGC ACAGAAGCCT GGGCCCGCCT CAAGGAGAAG AGGATTCAGT GCCAAGAGAT 6420 CTTCCTTCTT GGATGAAATT CCTCCATGGC AAACTGGGAA ATCCAATAGT ACCATTAAAT 6480 ATCCGTCTCT TCTTAGCCAA GCTTGTTATT AATACAGAAG AGGTCTTTCG CCCTTACGCG 6540 AAGCACTGGC TTAGCCCCTT GCTGCAGCTG GCTGCTTCTG AAAACAATGG AGGAGAAGGA 6600 ATTCACTACA TGGTGGTTGA GATAGTGGCC ACTATTCTTT CATGGACAGG CTTGGCCACT 6660 CCAACAGGGG TCCCTAAAGA TGAAGTGTTA GCAAATCGAT TGCTTAATTT CCTAATGAAA 6720 CATGTCTTTC ATCCAAAAAG AGCTGTGTTT AGACACAACC TTGAAATTAT AAAGACCCTT 6780 GTCGAGTGCT GGAAGGATTG TTTATCCATC CCTTATAGGT TAATATTTGA AAAGTTTTCC 6840 GGTAAAGATC CTAATTCTAA AGACAACTCA GTAGGGATTC AATTGCTAGG CATCGTGATG 6900 GCCAATGACC TGCCTCCCTA TGACCCACAG TGTGGCATCC AGAGTAGCGA ATACTTCCAG 6960 GCTTTGGTGA ATAATATGTC CTTTGTAAGA TATAAAGAAG TGTATGCCGC TGCAGCAGAA 7020 GTTCTAGGAC TTATACTTCG ATATGTTATG GAGAGAAAAA ACATACTGGA GGAGTCTCTG 7080 TGTGAACTGG TTGCGAAACA ATTGAAGCAA CATCAGAATA CTATGGAGGA CAAGTTTATT 7140 GTGTGCTTGA ACAAAGTGAC CAAGAGCTTC CCTCCTCTTG CAGACAGGTT CATGAATGCT 7200 GTGTTCTTTC TGCTGCCAAA ATTTCATGGA GTGTTGAAAA CACTCTGTCT GGAGGTGGTA 7260 CTTTGTCGTG TGGAGGGAAT GACAGAGCTG TACTTCCAGT TAAAGAGCAA GGACTTCGTT 7320 CAAGTCATGA GACATAGAGA TGATGAAAGA CAAAAAGTAT GTTTGGACAT AATTTATAAG 7380 ATGATGCCAA AGTTAAAACC AGTAGAACTC GGAGAACTTC TGAACCCCGT TGTGGAATTC 7440 GTTTCCCATC CTTCTACAAC ATGTAGGGAA CAAATGTATA ATATTCTCAT GTGGATTCAT 7500 GATAATTACA GAGATCCAGA AAGTGAGACA GATAATGACT CCCAGGAAAT ATTTAAGTTG 7560 GCAAAAGATG TGCTGATTCA AGGATTGATC GATGAGAACC CTGGACTTCA ATTAATTATT 7620 CGAAATTTCT GGAGCCATGA AACTAGGTTA CCTTCAAATA CCTTGGACCG GTTGCTGGCA 7680 CTAAATTCCT TATATTCTCC TAAGATAGAA GTGCACTTTT TAAGTTTAGC AACAAATTTT 7740 CTGCTCGAAA TGACCAGCAT GAGCCCAGAT TATCCAAACC CCATGTTCGA GCATCCTCTG 7800 TCAGAATGCG AATTTCAGGA ATATACCATT GATTCTGATT GGCGTTTCCG AAGTACTGTT 7860 CTCACTCCGA TGTTTGTGGA GACCCAGGCC TCCCAGGGCA CTCTCCAGAC CCGTACCCAG 7920 GAAGGGTCCC TCTCAGCTCG CTGGCCAGTG GCAGGGCAGA TAAGGGCCAC CCAGCAGCAG 7980 CATGACTTCA CACTGACACA GACTGCAGAT GGAAGAAGCT CATTTGATTG GCTGACCGGG 8040 AGCAGCACTG ACCCGCTGGT CGACCACACC AGTCCCTCAT CTGACTCCTT GCTGTTTGCC 8100 CACAAGAGGA GTGAAAGGTT ACAGAGAGCA CCCTTGAAGT CAGTGGGGCC TGATTTTGGG 8160 AAAAAAAGGC TGGGCCTTCC AGGGGACGAG GTGGATAACA AAGTGAAAGG TGCGGCCGGC 8220 CGGACGGACC TACTACGACT GCGCAGACGG TTTATGAGGG ACCAGGAGAA GCTCAGTTTG 8280 ATGTATGCCA GAAAAGGCGT TGCTGAGCAA AAACGAGAGA AGGAAATCAA GAGTGAGTTA 8340 AAAATGAAGC AGGATGCCCA GGTCGTTCTG TACAGAAGCT ACCGGCACGG AGACCTTCCT 8400 GACATTCAGA TCAAGCACAG CAGCCTCATC ACCCCGTTAC AGGCCGTGGC CCAGAGGGAC 8460 CCAATAATTG CAAAACAGCT CTTTAGCAGC TTGTTTTCTG GAATTTTGAA AGAGATGGAT 8520 AAATTTAAGA CACTGTCTGA AAAAAACAAC ATCACTCAAA AGTTGCTTCA AGACTTCAAT 8580 CGTTTTCTTA ATACCACCTT CTCTTTCTTT CCACCCTTTG TCTCTTGTAT TCAGGACATT 8640 AGCTGTCAGC ACGCAGCCCT GCTGAGCCTC GACCCAGCGG CTGTTAGCGC TGGTTGCCTG 8700 GCCAGCCTAC AGCAGCCCGT GGGCATCCGC CTGCTAGAGG AGGCTCTGCT CCGCCTGCTG 8760 CCTGCTGAGC TGCCTGCCAA GCGAGTCCGT GGGAAGGCCC GCCTCCCTCC TGATGTCCTC 8820 AGATGGGTGG AGCTTGCTAA GCTGTATAGA TCAATTGGAG AATACGACGT CCTCCGTGGG 8880 ATTTTTACCA GTGAGATAGG AACAAAGCAA ATCACTCAGA GTGCATTATT AGCAGAAGCC 8940 AGAAGTGATT ATTCTGAAGC TGCTAAGCAG TATGATGAGG CTCTCAATAA ACAAGACTGG 9000 GTAGATGGTG AGCCCACAGA AGCCGAGAAG GATTTTTGGG AACTTGCATC CCTTGACTGT 9060 TACAACCACC TTGCTGAGTG GAAATCACTT GAATACTGTT CTACAGCCAG TATAGACAGT 9120 GAGAACCCCC CAGACCTAAA TAAAATCTGG AGTGAACCAT TTTATCAGGA AACATATCTA 9180 CCTTACATGA TCCGCAGCAA GCTGAAGCTG CTGCTCCAGG GAGAGGCTGA CCAGTCCCTG 9240 CTGACATTTA TTGACAAAGC TATGCACGGG GAGCTCCAGA AGGCGATTCT AGAGCTTCAT 9300 TACAGTCAAG AGCTGAGTCT GCTTTACCTC CTGCAAGATG ATGTTGACAG AGCCAAATAT 9360 TACATTCAAA ATGGCATTCA GAGTTTTATG CAGAATTATT CTAGTATTGA TGTCCTCTTA 9420 CACCAAAGTA GACTCACCAA ATTGCAGTCT GTACAGGCTT TAACAGAAAT TCAGGAGTTC 9480 ATCAGCTTTA TAAGCAAACA AGGCAATTTA TCATCTCAAG TTCCCCTTAA GAGACTTCTG 9540 AACACCTGGA CAAACAGATA TCCAGATGCT AAAATGGACC CAATGAACAT CTGGGATGAC 9600 ATCATCACAA ATCGATGTTT CTTTCTCAGC AAAATAGAGG AGAAGCTTAC CCCTCTTCCA 9660 GAAGATAATA GTATGAATGT GGATCAAGAT GGAGACCCCA GTGACAGGAT GGAAGTGCAA 9720 GAGCAGGAAG AAGATATCAG CTCCCTGATC AGGAGTTGCA AGTTTTCCAT GAAAATGAAG 9780 ATGATAGACA GTGCCCGGAA GCAGAACAAT TTCTCACTTG CTATGAAACT ACTGAAGGAG 9840 CTGCATAAAG AGTCAAAAAC CAGAGACGAT TGGCTGGTGA GCTGGGTGCA GAGCTACTGC 9900 CGCCTGAGCC ACTGCCGGAG CCGGTCCCAG GGCTGCTCTG AGCAGGTGCT CACTGTGCTG 9960 AAAACAGTCT CTTTGTTGGA TGAGAACAAC GTGTCAAGCT ACTTAAGCAA AAATATTCTG 10020 GCTTTCCGTG ACCAGAACAT TCTCTTGGGT ACAACTTACA GGATCATAGC GAATGCTCTC 10080 AGCAGTGAGC CAGCCTGCCT TGCTGAAATC GAGGAGGACA AGGCTAGAAG AATCTTAGAG 10140 CTTTCTGGAT CCAGTTCAGA GGATTCAGAG AAGGTGATCG CGGGTCTGTA CCAGAGAGCA 10200 TTCCAGCACC TCTCTGAGGC TGTGCAGGCG GCTGAGGAGG AGGCCCAGCC TCCCTCCTGG 10260 AGCTGTGGGC CTGCAGCTGG GGTGATTGAT GCTTACATGA CGCTGGCAGA TTTCTGTGAC 10320 CAACAGCTGC GCAAGGAGGA AGAGAATGCA TCAGTTATTG ATTCTGCAGA ACTGCAGGCG 10380 TATCCAGCAC TTGTGGTGGA GAAAATGTTG AAAGCTTTAA AATTAAATTC CAATGAAGCC 10440 AGATTGAAGT TTCCTAGATT ACTTCAGATT ATAGAACGGT ATCCAGAGGA GACTTTGAGC 10500 CTCATGACAA AAGAGATCTC TTCCGTTCCC TGCTGGCAGT TCATCAGCTG GATCAGCCAC 10560 ATGGTGGCCT TACTGGACAA AGACCAAGCC GTTGCTGTTC AGCACTCTGT GGAAGAAATC 10620 ACTGATAACT ACCCGCAGGC TATTGTTTAT CCCTTCATCA TAAGCAGCGA AAGCTATTCC 10680 TTCAAGGATA CTTCTACTGG TCATAAGAAT AAGGAGTTTG TGGCAAGGAT TAAAAGTAAG 10740 TTGGATCAAG GAGGAGTGAT TCAAGATTTT ATTAATGCCT TAGATCAGCT CTCTAATCCT 10800 GAACTGCTCT TTAAGGATTG GAGCAATGAT GTAAGAGCTG AACTAGCAAA AACCCCTGTA 10860 AATAAAAAAA ACATTGAAAA AATGTATGAA AGAATGTATG CAGCCTTGGG TGACCCAAAG 10920 GCTCCAGGCC TGGGGGCCTT TAGAAGGAAG TTTATTCAGA CTTTTGGAAA AGAATTTGAT 10980 AAACATTTTG GGAAAGGAGG TTCTAAACTA CTGAGAATGA AGCTCAGTGA CTTCAACGAC 11040 ATTACCAACA TGCTACTTTT AAAAATGAAC AAAGACTCAA AGCCCCCTGG GAATCTGAAA 11100 GAATGTTCAC CCTGGATGAG CGACTTCAAA GTGGAGTTCC TGAGAAATGA GCTGGAGATT 11160 CCCGGTCAGT ATGACGGTAG GGGAAAGCCA TTGCCAGAGT ACCACGTGCG AATCGCCGGG 11220 TTTGATGAGC GGGTGACAGT CATGGCGTCT CTGCGAAGGC CCAAGCGCAT CATCATCCGT 11280 GGCCATGACG AGAGGGAACA CCCTTTCCTG GTGAAGGGTG GCGAGGACCT GCGGCAGGAC 11340 CAGCGCGTGG AGCAGCTCTT CCAGGTCATG AATGGGATCC TGGCCCAAGA CTCCGCCTGC 11400 AGCCAGAGGG CCCTGCAGCT GAGGACCTAT AGCGTTGTGC CCATGACCTC CAGGTTAGGA 11460 TTAATTGAGT GGCTTGAAAA TACTGTTACC TTGAAGGACC TTCTTTTGAA CACCATGTCC 11520 CAAGAGGAGA AGGCGGCTTA CCTGAGTGAT CCCAGGGCAC CGCCGTGTGA ATATAAAGAT 11580 TGGCTGACAA AAATGTCAGG AAAACATGAT GTTGGAGCTT ACATGCTAAT GTATAAGGGC 11640 GCTAATCGTA CTGAAACAGT CACGTCTTTT AGAAAACGAG AAAGTAAAGT GCCTGCTGAT 11700 CTCTTAAAGC GGGCCTTCGT GAGGATGAGT ACAAGCCCTG AGGCTTTCCT GGCGCTCCGC 11760 TCCCACTTCG CCAGCTCTCA CGCTCTGATA TGCATCAGCC ACTGGATCCT CGGGATTGGA 11820 GACAGACATC TGAACAACTT TATGGTGGCC ATGGAGACTG GCGGCGTGAT CGGGATCGAC 11880 TTTGGGCATG CGTTTGGATC CGCTACACAG TTTCTGCCAG TCCCTGAGTT GATGCCTTTT 11940 CGGCTAACTC GCCAGTTTAT CAATCTGATG TTACCAATGA AAGAAACGGG CCTTATGTAC 12000 AGCATCATGG TACACGCACT CCGGGCCTTC CGCTCAGACC CTGGCCTGCT CACCAACACC 12060 ATGGATGTGT TTGTCAAGGA GCCCTCCTTT GATTGGAAAA ATTTTGAACA GAAAATGCTG 12120 AAAAAAGGAG GGTCATGGAT TCAAGAAATA AATGTTGCTG AAAAAAATTG GTACCCCCGA 12180 CAGAAAATAT GTTACGCTAA GAGAAAGTTA GCAGGTGCCA ATCCAGCAGT CATTACTTGT 12240 GATGAGCTAC TCCTGGGTCA TGAGAAGGCC CCTGCCTTCA GAGACTATGT GGCTGTGGCA 12300 CGAGGAAGCA AAGATCACAA CATTCGTGCC CAAGAACCAG AGAGTGGGCT TTCAGAAGAG 12360 ACTCAAGTGA AGTGCCTGAT GGACCAGGCA ACAGACCCCA ACATCCTTGG CAGAACCTGG 12420 GAAGGATGGG AGCCCTGGAT GTGAGGTCTG TGGGAGTCTG CAGATAGAAA GCATTACATT 12480 GTTTAAAGAA TCTACTATAC TTTGGTTGGC AGCATTCCAT GAGCTGATTT TCCTGAAACA 12540 CTAAAGAGAA ATGTCTTTTG TGCTACAGTT TCGTAGCATG AGTTTAAATC AAGATTATGA 12600 TGAGTAAATG TGTATGGGTT AAATCAAAGA TAAGGTTATA GTAACATCAA AGATTAGGTG 12660 AGGTTTATAG AAAGATAGAT ATCCAGGCTT ACCAAAGTAT TAAGTCAAGA ATATAATATG 12720 TGATCAGCTT TCAAAGCATT TACAAGTGCT GCAAGTTAGT GAAACAGCTG TCTCCGTAAA 12780 TGGAGGAAAT GTGGGGAAGC CTTGGAATGC CCTTCTGGTT CTGGCACATT GGAAAGCACA 12840 CTCAGAAGGC TTCATCACCA AGATTTTGGG AGAGTAAAGC TAAGTATAGT TGATGTAACA 12900 TTGTAGAAGC AGCATAGGAA CAATAAGAAC AATAGGTAAA GCTATAATTA TGGCTTATAT 12960 TTAGAAATGA CTGCATTTGA TATTTTAGGA TATTTTTCTA GGTTTTTTCC TTTCATTTTA 13020 TTCTCTTCTA GTTTTGACAT TTTATGATAG ATTTGCTCTC TAGAAGGAAA CGTCTTTATT 13080 TAGGAGGGCA AAAATTTTGG TCATAGCATT CACTTTTGCT ATTCCAATCT ACAACTGGAA 13140 GATACATAAA AGTGCTTTGC ATTGAATTTG GGATAACTTC AAAAATCCCA TGGTTGTTGT 13200 TAGGGATAGT ACTAAGCATT TCAGTTCCAG GAGAATAAAA GAAATTCCTA TTTGAAATGA 13260 ATTCCTCATT TGGAGGAAAA AAAGCATGCA TTCTAGCACA ACAAGATGAA ATTATGGAAT 13320 ACAAAAGTGG CTCCTTCCCA TGTGCAGTCC CTGTCCCCCC CCGCCAGTCC TCCACACCCA 13380 AACTGTTTCT GATTGGCTTT TAGCTTTTTG TTGTTTTTTT TTTTCCTTCT AACACTTGTA 13440 TTTGGAGGCT CTTCTGTGAT TTTGAGAAGT ATACTCTTGA GTGTTTAATA AAGTTTTTTT 13500 CCAAAAGTA

Seq ID NO: 99 Protein sequence: Protein Accession #: NP_008835.5

1 11 21 31 41 51

M IAGSGAGVRC SILLRLQETLS AIADRCGAALA GIHQLIRGLGQ EICVLSSSPAV LIALQTSLVFS 60

RDFGLLVFVR KSLNSIEFRE CREEILKFLC IFLEKMGQKI APYSVEIKNT CTSVYTKDRA 120

AKCKIPALDL LIKLLQTFRS SRLMDEFKIG ELFSKFYGEL ALKKKIPDTV LEKVYELLGL 180

LGEVHPSEMI NNAENLFRAF LGELKTQMTS AVREPKLPVL AGCLKGLSSL LCNFTKSMEE 240

DPQTSREIFN FVLKAIRPQI DLKRYAVPSA GLRLFALHAS QFSTCLLDNY VSLFEVLLKW 300

CAHTNVELKK AALSALESFL KQVSNMVAKN AEMHKNKLQY FMEQFYGIIR NVDSNNKELS 360 IAIRGYGLFA GPCKVINAKD VDFMYVELIQ RCKQMFLTQT DTGDDRVYQM PSFLQSVASV 420 LLYLDTVPEV YTPVLEHLW MQIDSFPQYS PKMQLVCCRA IVKVFLALAA KGPVLRNCIS 480 TWHQGLIRI CSKPWLPKG PESESEDHRA SGEVRTGKWK VPTYKDYVDL FRHLLSSDQM 540 MDSILADEAF FSVNSSSESL NHLLYDEFVK SVLKIVEKLD LTLEIQTVGE QENGDEAPGV 600 WMIPTSDPAA NLHPAKPKDF SAFINLVEFC REILPEKQAE FFEPWVYSFS YELILQSTRL 660 PLISGFYKLL SITVRNAKKI KYFEGVSPKS LKHSPEDPEK YSCFALFVKF GKEVAVKMKQ 720 YKDELLASCL TFLLSLPHNI IELDVRAYVP ALQMAFKLGL SYTPLAEVGL NALEEWSIYI 780 DRHVMQPYYK DILPCLDGYL KTSALSDETK NNWEVSALSR AAQKGFNKW LKHLKKTKNL 840 SSNEAISLEE IRIRWQMLG SLGGQINKNL LTVTSSDEMM KSYVAWDREK RLSFAVPFRE 900 MKPVIFLDVF LPRVTELALT ASDRQTKVAA CELLHSMVMF MLGKATQMPE GGQGAPPMYQ 960 LYKRTFPVLL RLACDVDQVT RQLYEPLVMQ LIHWFTNNKK FESQDTVALL EAILDGIVDP 1020 VDSTLRDFCG RCIREFLKWS IKQITPQQQE KSPVNTKSLF KRLYSLALHP NAFKRLGASL 1080 AFNNIYREFR EEESLVEQFV FEALVIYMES LALAHADEKS LGTIQQCCDA IDHLCRIIEK 1140 KHVSLNKAKK RRLPRGFPPS ASLCLLDLVK WLLAHCGRPQ TECRHKSIEL FYKFVPLLPG 1200 NRSPNLWLKD VLKEEGVSFL INTFEGGGCG QPSGILAQPT LLYLRGPFSL QATLCWLDLL 1260 LAALECYNTF IGERTVGALQ VLGTEAQSSL LKAVAFFLES IAMHDIIAAE KCFGTGAAGN 1320 RTSPQEGERY NYSKCTVWR IMEFTTTLLN TSPEGWKLLK KDLCNTHLMR VLVQTLCEPA 1380 SIGFNIGDVQ VMAHLPDVCV NLMKALKMSP YKDILETHLR EKITAQSIEE LCAVNLYGPD 1440 AQVDRSRLAA WSACKQLHR AGLLHNILPS QSTDLHHSVG TELLSLVYKG lAPGDERQCL 1500 PSLDLSCKQL ASGLLELAFA FGGLCERLVS LLLNPAVLST ASLGSSQGSV IHPSHGEYFY 1560 SLFSETINTE LLKNLDLAVL ELMQSSVDNT KMVSAVLNGM LDQSFRERAN QKHQGLKLAT 1620 TILQH KKCD SWWAKDSPLE TKMAVLALLA KILQIDSSVS FNTSHGSFPE VFTTYISLLA 1680 DTKLDLHLKG QAVTLLPFFT SLTGGSLEEL RRVLEQLIVA HFPMQSREFP PGTPRFNNYV 1740 DCMKKFLDAL ELSQSPMLLE LMTEVLCREQ QHVMEELFQS SFRRIARRGS CVTQVGLLES 1800 VYEMFRKDDP RLSFTRQSFV DRSLLTLLWH CSLDALREFF STIWDAIDV LKSRFTKLNE 1860 STFDTQITKK MGYYKILDVM YSRLPKDDVH AKESKINQVF HGSCITEGNE LTKTLIKLCY 1920 DAFTENMAGE NQLLERRRLY HCAAYNCAIS VICCVFNELK FYQGFLFSEK PEKNLLIFEN 1980 LIDLKRRYNF PVEVEVPMER KKKYIEIRKE AREAANGDSD GPSYMSSLSY LADSTLSEEM 2040 SQFDFSTGVQ SYSYSSQDPR PATGRFRRRE QRDPTVHDDV LELEMDELNR HECMAPLTAL 2100 VKHMHRSLGP PQGEEDSVPR DLPSWMKFLH GKLGNPIVPL NIRLFLAKLV INTEEVPRPY 2160 AKHWLSPLLQ LAASENNGGE GIHYMWEIV ATILSWTGLA TPTGVPKDEV LANRLLNFLM 2220 KHVFHPKRAV FRHNLEIIKT LVECWKDCLS IPYR IFEKF SGKDPNSKDN SVGIQLLGIV 2280 MANDLPPYDP QCGIQSSEYF QALVNNMSFV RYKEVYAAAA EVLGLILRYV MERKNILEES 2340 LCELVAKQLK QHQNTMEDKF IVCLNKVTKS FPPLADRFMN AVFFLLPKFH GVLKTLCLEV 2400 VLCRVEGMTE LYFQLKSKDF VQVMRHRDDE RQKVCLDIIY KMMPKLKPVE LRELLNPWE 2460 FVSHPSTTCR EQMYNILMWI HDNYRDPESE TDNDSQEIFK LAKDVLIQGL IDENPGLQLI 2520 IRNFWSHETR LPSNTLDRLL ALNSLYSPKI EVHFLSLATN FLLEMTSMSP DYPNPMFEHP 2580 LSECEFQEYT IDSDWRFRST VLTPMFVETQ ASQGTLQTRT QEGSLSARWP VAGQIRATQQ 2640 QHDFTLTQTA DGRSSFDWLT GSSTDPLVDH TSPSSDSLLF AHKRSERLQR APLKSVGPDF 2700 GKKRLGLPGD EVDNKVKGAA GRTDLLRLRR RFMRDQEKLS LMYARKGVAE QKREKEIKSE 2760 LKMKQDAQW LYRSYRHGDL PDIQIKHSSL ITPLQAVAQR DPIIAKQLFS SLFSGILKEM 2820 DKFKTLSEKN NITQKLLQDF NRFLNTTFSF FPPFVSCIQD ISCQHAALLS LDPAAVSAGC 2880 LASLQQPVGI RLLEEALLRL LPAELPAKRV RGKARLPPDV LRWVELAKLY RSIGEYDVLR 2940 GIFTSEIGTK QITQSALLAE ARSDYSEAAK QYDEALNKQD WVDGEPTEAE KDFWELASLD 3000 CYNHLAEWKS LEYCSTASID SENPPDLNKI WSEPFYQETY LPYMIRSKLK LLLQGEADQS 3060 LLTFIDKAMH GELQKAILEL HYSQELSLLY LLQDDVDRAK YYIQNGIQSF MQNYSSIDVL 3120 LHQSRLTKLQ SVQALTEIQE FISFISKQGN LSSQVPLKRL LNTWTNRYPD AKMDPMNIWD 3180 DIITNRCFFL SKIEEKLTPL PEDNSMNVDQ DGDPSDRMEV QEQEEDISSL IRSCKFSMKM 3240 KMIDSARKQN NFSLAMKLLK ELHKESKTRD DWLVSWVQSY CRLSHCRSRS QGCSEQVLTV 3300 LKTVSLLDEN NVSSYLSKNI LAFRDQNILL GTTYRIIANA LSSEPACLAE IEEDKARRIL 3360 ELSGSSSEDS EKVIAGLYQR AFQHLSEAVQ AAEEEAQPPS WSCGPAAGVI DAYMTLADFC 3420 DQQLRKEEEN ASVIDSAELQ AYPALWEKM LKALKLNSNE ARLKFPRLLQ IIERYPEETL 3480 SLMTKEISSV PCWQFISWIS HMVALLDKDQ AVAVQHSVEE ITDNYPQAIV YPFIISSESY 3540 SFKDTSTGHK NKEFVARIKS KLDQGGVIQD FINALDQLSN PELLFKDWSN DVRAELAKTP 3600 VNKKNIEKMY ERMYAALGDP KAPGLGAPRR KFIQTFGKEF DKHFGKGGSK LLRMKLSDFN 3660 DITNMLLLKM NKDSKPPGNL KECSPWMSDF KVEFLRNELE IPGQYDGRGK PLPEYHVRIA 3720 GFDERVTVMA SLRRPKRIII RGHDEREHPF LVKGGEDLRQ DQRVEQLFQV MNGILAQDSA 3780 CSQRALQLRT YSWPMTSRL GLIEWLENTV TLKDLLLNTM SQEEKAAYLS DPRAPPCEYK 3840 DWLTKMSGKH DVGAYMLMYK GANRTETVTS FRKRESKVPA DLLKRAFVRM STSPEAFLAL 3900 RSHFASSHAL ICISHWILGI GDRHLNNFMV AMETGGVIGI DFGHAFGSAT QFLPVPELMP 3960 FRLTRQFINL MLPMKETGLM YSIMVHALRA FRSDPGLLTN TMDVFVKEPS FDWKNFEQKM 4020 LKKGGS IQE INVAEKN YP RQKICYAKRK LAGANPAVIT CDELLLGHEK APAFRDYVAV 4080 ARGSKDHNIR AQEPESGLSE ETQVKCLMDQ ATDPNILGRT WEGWEPWM

Seq ID NO: 100 DNA sequence Nucleic Acid Accession #: NM_000673 Coding sequence: 101-1225

11 21 31 41 51

I I I I I

ATGTGAAGGC ACAAGCTGCT GTTATATACA ACAGAGTGAA CTGAGCATCA GTCAGAAAAA 60 GTCTATGTTT GCAGAAATAC AGATCCAAGA CAAAGACAGG ATGGGCACTG CTGGAAAAGT 120 TATTAAATGC AAAGCAGCTG TGCTTTGGGA GCAGAAGCAA CCCTTCTCCA TTGAGGAAAT 180 AGAAGTTGCC CCACCAAAGA CTAAAGAAGT TCGCATTAAG ATTTTGGCCA CAGGAATCTG 240 TCGCACAGAT GACCATGTGA TAAAAGGAAC AATGGTGTCC AAGTTTCCAG TGATTGTGGG 300 ACATGAGGCA ACTGGGATTG TAGAGAGCAT TGGAGAAGGA GTGACTACAG TGAAACCAGG 360 TGACAAAGTC ATCCCTCTCT TTCTGCCACA ATGTAGAGAA TGCAATGCTT GTCGCAACCC 420 AGATGGCAAC CTTTGCATTA GGAGCGATAT TACTGGTCGT GGAGTACTGG CTGATGGCAC 480 CACCAGATTT ACATGCAAGG GCAAACCAGT ACACCACTTC ATGAACACCA GTACATTTAC 540 CGAGTACACA GTGGTGGATG AATCTTCTGT TGCTAAGATT GATGATGCAG CTCCTCCTGA 600 GAAAGTCTGT TTAATTGGCT GTGGGTTTTC CACTGGATAT GGCGCTGCTG TTAAAACTGG 660 CAAGGTCAAA CCTGGTTCCA CTTGCGTCGT CTTTGGCCTG GGAGGAGTTG GCCTGTCAGT 720 CATCATGGGC TGTAAGTCAG CTGGTGCATC TAGGATCATT GGGATTGACC TCAACAAAGA 780 CAAATTTGAG AAGGCCATGG CTGTAGGTGC CACTGAGTGT ATCAGTCCCA AGGACTCTAC 840 CAAACCCATC AGTGAGGTGC TGTCAGAAAT GACAGGCAAC AACGTGGGAT ACACCTTTGA 900 AGTTATTGGG CATCTTGAAA CCATGATTGA TGCCCTGGCA TCCTGCCACA TGAACTATGG 960 GACCAGCGTG GTTGTAGGAG TTCCTCCATC AGCCAAGATG CTCACCTATG ACCCGATGTT 1020 GCTCTTCACT GGACGCACAT GGAAGGGATG TGTCTTTGGA GGTTTGAAAA GCAGAGATGA 1080

TGTCCCAAAA CTAGTGACTG AGTTCCTGGC AAAGAAATTT GACCTGGACC AGTTGATAAC 1140

TCATGTTTTA CCATTTAAAA AAATCAGTGA AGGATTTGAG CTGCTCAATT CAGGACAAAG 1200

CATTCGAACG GTCCTGACGT TTTGAGATCC AAAGTGGCAG GAGGTCTGTG TTGTCATGGT 1260

GAACTGGAGT TTCTCTTGTG AGAGTTCCCT CATCTGAAAT CATGTATCTG TCTCACAAAT 1320

ACAAGCATAA GTAGAAGATT TGTTGAAGAC ATAGAACCCT TATAAAGAAT TATTAACCTT 1380

TATAAACATT TAAAGTCTTG TGAGCACCTG GGAATTAGTA TAATAACAAT GTTAATATTT 1440

TTGATTTACA TTTTGTAAGG CTATAATTGT ATCTTTTAAG AAAACATACA CTTGGATTTC 1500

TATGTTGAAA TGGAGATTTT TAAGAGTTTT AACCAGCTGC TGCAGATATA TAACTCAAAA 1560

CAGATATAGC GTATAAAGAT ATAGTAAATG CATCTCCCAG AGTAATATTC ACTTAACACA 1620

TTGAAACTAT TATTTTTTAG ATTTGAATAT AAATGTATTT TTTAAACACT TGTTATGAGT 1680

TAACTTGGAT TACATTTTGA AATCAGTTCA TTCCATGATG CATATTACTG GATTAGATTA 1740

AGAAAGACAG AAAAGATTAA GGGACGGGCA CATTTTTCAA CGATTAAGAA TCATCATTAC 1800

ATAACTTGGT GAAACTGAAA AAGTATATCA TATGGGTACA CAAGGCTATT TGCCAGCATA 1860

TATTAATATT TTAGAAAATA TTCCTTTTGT AATACTGAAT ATAAACATAG AGCTAGAGTC 1920

ATATTATCAT ACTTATCATA ATGTTCAATT TGATACAGTA GAATTGCAAG TCCCTAAGTC 1980

CCTATTCACT GTGCTTAGTA GTGACTCCAT TTAATAAAAA GTGTTTTTAG TTTTTAACAA 2040 CTAAACCG

Seq ID NO: 101 Protein sequence: Protein Accession #: NP 000664

11 41 51

MGTAGKVIKC KAAVLWEQKQ PFSIEEIEVA PPKTKEVRIK I ATGICRTD DHVIKGTMVS 60

KFPVIVGHEA TGIVESIGEG VTTVKPGDKV IPLFLPQCRE CNACRNPDGN LCIRSDITGR 120

GVLADGTTRF TCKGKPVHHF MNTSTFTEYT WDESSVAKI DDAAPPEKVC LIGCGFSTGY 180

GAAVKTGKVK PGSTCWEGL GGVGLSVIMG CKSAGASRII GIDLNKDKFE KAMAVGATEC 240

ISPKDSTKPI SEVLSEMTGN NVGYTFEVIG HLETMIDALA SCHMNYGTSV WGVPPSAKM 300

LTYDPMLLFT GRTWKGCVFG GLKSRDDVPK LVTEFLAKKF DLDQLITHVL PFKKISEGFE 360

LLNSGQSIRT VLTF

Seq ID NO: 102 DNA sequence Nucleic Acid Accession #: NM_006783.1 Coding sequence: 1..786

11 21 31 41 51

ATGGATTGGG GGACGCTGCA CACTTTCATC GGGGGTGTCA ACAAACACTC CACCAGCATC 60 GGGAAGGTGT GGATCACAGT CATCTTTATT TTCCGAGTCA TGATCCTAGT GGTGGCTGCC 120 CAGGAAGTGT GGGGTGACGA GCAAGAGGAC TTCGTCTGCA ACACACTGCA ACCGGGATGC 180 AAAAATGTGT GCTATGACCA CTTTTTCCCG GTGTCCCACA TCCGGCTGTG GGCCCTCCAG 240 CTGATCTTCG TCTCCACCCC AGCGCTGCTG GTGGCCATGC ATGTGGCCTA CTACAGGCAC 300 GAAACCACTC GCAAGTTCAG GCGAGGAGAG AAGAGGAATG ATTTCAAAGA CATAGAGGAC 360 ATTAAAAAGC ACAAGGTTCG GATAGAGGGG TCGCTGTGGT GGACGTACAC CAGCAGCATC 420 TTTTTCCGAA TCATCTTTGA AGCAGCCTTT ATGTATGTGT TTTACTTCCT TTACAATGGG 480 TACCACCTGC CCTGGGTGTT GAAATGTGGG ATTGACCCCT GCCCCAACCT TGTTGACTGC 540 TTTATTTCTA GGCCAACAGA GAAGACCGTG TTTACCATTT TTATGATTTC TGCGTCTGTG 600 ATTTGCATGC TGCTTAACGT GGCAGAGTTG TGCTACCTGC TGCTGAAAGT GTGTTTTAGG 660 AGATCAAAGA GAGCACAGAC GCAAAAAAAT CACCCCAATC ATGCCCTAAA GGAGAGTAAG 720 CAGAATGAAA TGAATGAGCT GATTTCAGAT AGTGGTCAAA ATGCAATCAC AGGTTTCCCA 780 AGCTAA

Seq ID NO: 103 Protein sequence: Protein Accession #: NP 006774.1

1 11 21 31 41 51

I I I I 1 1

MDWGTLHTFI GGVNKHSTSI GKVWITVIFI FRVMILWAA QEVWGDEQED FVCNTLQPGC 60 KNVCYDHFFP VSHIRLWALQ LIFVSTPALL VAMHVAYYRH ETTRKFRRGE KRNDFKDIED 120 IKKHKVRIEG SLWWTYTSSI FFRIIFEAAF MYVFYFLYNG YHLPWVLKCG IDPCPNLVDC 180 FISRPTEKTV FTIFMISASV ICMLLNVAEL CYLLLKVCFR RSKRAQTQKN HPNHALKESK 240 QNEMNELISD SGQNAITGFP S Seq ID NO: 104 DNA sequence

Nucleic Acid Accession #: NM_020411 Coding sequence: 86-526

11 21 31 41 51

I I I I

GGACCTGGGA AGGAGCATAG GACAGGGCAA GGCGGGATAA GGAGGGGCAC CACAGCCCTT 60 AAGGCACGAG GGAACCTCAC TGCGCATGCT CCTTTGGTGC CCACCTCAGT GCGCATGTTC 120 ACTGGGCGTC TTCCCATCGG CCCCTTCGCC AGTGTGGGGA ACGCGGCGGA GCTGTGAGCC 180 GGCGACTCGG GTCCCTGAGG TCTGGATTCT TTCTCCGCTA CTGAGACACG GCGGACACAC 240 ACAAACACAG AACCACACAG CCAGTCCCAG GAGCCCAGTA ATGGAGAGCC CCAAAAAGAA 300 GAACCAGCAG CTGAAAGTCG GGATCCTACA CCTGGGCAGC AGACAGAAGA AGATCAGGAT 360 ACAGCTGAGA TCCCAGTGCG CGACATGGAA GGTGATCTGC AAGAGCTGCA TCAGTCAAAC 420 ACCGGGGATA AATCTGGATT TGGGTTCCGG CGTCAAGGTG AAGATAATAC CTAAAGAGGA 480 ACACTGTAAA ATGCCAGAAG CAGGTGAAGA GCAACCACAA GTTTAAATGA AGACAAGCTG 540 AAACAACGCA AGCTGGTTTT ATATTAGATA TTTGACTTAA ACTATCTCAA TAAAGTTTTG 600 CAGCTTTCAC CAAAAAAAAA AAAAAA

Seq ID NO: 105 Protein sequence: Protein Accession #: NP 065144.1

21 31 I I I I I I

MLLWCPPQCA CSLGVFPSAP SPVWGTRRSC EPATRVPEVW ILSPLLRHGG HTQTQNHTAS 60 PRSPVMESPK KKNQQLKVGI LHLGSRQKKI RIQLRSQCAT WKVICKSCIS QTPGINLDLG 120 SGVKVKIIPK EEHCKMPEAG EEQPQV

Seq ID NO: 106 DNA sequence Nucleic Acid Accession #: J04129 Coding sequence: 99-587

1 11 21 31 41 51

I I I I I I

CATCCCTCTG GCTCCAGAGC TCAGAGCCAC CCACAGCCGC AGCCATGCTG TGCCTCCTGC 60

TCACCCTGGG CGTGGCCCTG GTCTGTGGTG TCCCGGCCAT GGACATCCCC CAGACCAAGC 120

AGGACCTGGA GCTCCCAAAG TTGGCAGGGA CCTGGCACTC CATGGCCATG GCGACCAACA 180

ACATCTCCCT CATGGCGACA CTGAAGGCCC CTCTGAGGGT CCACATCACC TCACTGTTGC 240

CCACCCCCGA GGACAACCTG GAGATCGTTC TGCACAGATG GGAGAACAAC AGCTGTGTTG 300

AGAAGAAGGT CCTTGGAGAG AAGACTGGGA ATCCAAAGAA GTTCAAGATC AACTATACGG 360

TGGCGAACGA GGCCACGCTG CTCGATACTG ACTACGACAA TTTCCTGTTT CTCTGCCTAC 420

AGGACACCAC CACCCCCATC CAGAGCATGA TGTGCCAGTA CCTGGCCAGA GTCCTGGTGG 480

AGGACGATGA GATCATGCAG GGATTCATCA GGGCTTTCAG GCCCCTGCCC AGGCACCTAT 540

GGTACTTGCT GGACTTGAAA CAGATGGAAG AGCCGTGCCG TTTCTAGCTC ACCTCCGCCT 600

CCAGGAAGAC CAGACTCCCA CCCTTCCACA CCTCCAGAGC AGTGGGACTT CCTCCTGCCC 660

TTTCAAAGAA TAACCACAGC TCAGAAGACG ATGACGTGGT CATCTGTGTC GCCATCCCCT 720

TCCTGCTGCA CACCTGCACC ATTGCCATGG GGAGGCTGCT CCCTGGGGGC AGAGTCTCTG 780 GCAGAGGTTA TTAATAAACC CTTGGAGCAT G

Seq ID NO: 107 Protein sequence: Protein Accession ft: AAA60147

1 11 21 31 41 51

I I I I I I

MDIPQTKQDL ELPKLAGTWH SMAMATNNIS LMATLKAPLR VHITSLLPTP EDNLEIVLHR 60 WENNSCVEKK VLGEKTGNPK KFKINYTVAN EATLLDTDYD NFLFLCLQDT TTPIQSMMCQ 120 YLARVLVEDD EIMQGFIRAF RPLPRHLWYL LDLKQMEEPC RF

Seq ID NO: 108 DNA sequence

Nucleic Acid Accession #: Eos sequence

Coding sequence: 48-794

1 11 21 31 41 51

I 1 I I I I

TCCCAGGCAG CAGTTAGCCC GCCGCCCGCC TGTGTGTCCC CAGAGCCATG GAGAGAGCCA 60

GTCTGATCCA GAAGGCCAAG CTGGCAGAGC AGGCCGAACG CTATGAGGAC ATGGCAGCCT 120

TCATGAAAGG CGCCGTGGAG AAGGGCGAGG AGCTCTCCTG CGAAGAGCGA AACCTGCTCT 180

CAGTAGCCTA TAAGAACGTG GTGGGCGGCC AGAGGGCTGC CTGGAGGGTG CTGTCCAGTA 240

TTGAGCAGAA AAGCAACGAG GAGGGCTCGG AGGAGAAGGG GCCCGAGGTG CGTGAGTACC 300

GGGAGAAGGT GGAGACTGAG CTCCAGGGCG TGTGCGACAC CGTGCTGGGC CTGCTGGACA 360

GCCACCTCAT CAAGGAGGCC GGGGACGCCG AGAGCCGGGT CTTCTACCTG AAGATGAAGG 420

GTGACTACTA CCGCTACCTG GCCGAGGTGG CCACCGGTGA CGACAAGAAG CGCATCATTG 480

ACTCAGCCCG GTCAGCCTAC CAGGAGGCCA TGGACATCAG CAAGAAGGAG ATGCCGCCCA 540

CCAACCCCAT CCGCCTGGGC CTGGCCCTGA ACTTTTCCGT CTTCCACTAC GAGATCGCCA 600

ACAGCCCCGA GGAGGCCATC TCTCTGGCCA AGACCACTTT CGACGAGGCC ATGGCTGATC 660

TGCACACCCT CAGCGAGGAC TCCTACAAAG ACAGCACCCT CATCATGCAG CTGCTGCGAG 720

ACAACCTGAC ACTGTGGACG GCCGACAACG CCGGGGAAGA GGGGGGCGAG GCTCCCCAGG 780

AGCCCCAGAG CTGAGTGTTG CCCGCCACCG CCCCGCCCTG CCCCCTCCAG TCCCCCACCC 840

TGCCGAGAGG ACTAGTATGG GGTGGGAGGC CCCACCCTTC TCCCCTAGGC GCTGTTCTTG 900

CTCCAAAGGG CTCCGTGGAG AGGGACTGGC AGAGCTGAGG CCACCTGGGG CTGGGGATCC 960

CACTCTTCTT GCAGCTGTTG AGCGCACCTA ACCACTGGTC ATGCCCCCAC CCCTGCTCTC 1020

CGCACCCGCT TCCTCCCGAC CCCAGGACCA GGCTACTTCT CCCCTCCTCT TGCCTCCCTC 1080

CTGCCCCTGC TGCCTCTGAT CGTAGGAATT GAGGAGTGTC CCGCCTTGTG GCTGAGAACT 1140

GGACAGTGGC AGGGGCTGGA GATGGGTGTG TGTGTGTGTG TGTGTGTGTG TGTGTGTGTG 1200

CGCGCGCGCC AGTGCAAGAC CGAGATTGAG GGAAAGCATG TCTGCTGGGT GTGACCATGT 1260 TTCCTCTCAA TAAAGTTCCC CTGTGACACT C

Seq ID NO: 109 Protein sequence: Protein Accession #: NP 006133.1 1 11 21 31 41 51 i i i i i i

MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN WGGQRAAWR 60

VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKΞ AGDAESRVFY 120

LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH 180

YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG 240 EAPQEPQS

Seq ID NO: 110 DNA sequence Nucleic Acid Accession #: NM_000695 Coding sequence: 407-1564

1 11 21 31 41 51

1 I I I I I

CACGAGTTGG TTTGGGAGCT GCCAGTCTCC TGGGAGGATC GCAGTCAGCA GAGCAGGGCT 60

GAGGCCTGGG GGTAGGAGCA GAGCCTGCGC ATCTGGAGGC AGCATGTCCA AGAAAGGGAG 120

TGGAGGTGCA GCGAAGGACC CAGGGGCAGA GCCCACGCTG GGGATGGACC CCTTCGAGGA 180

CACACTGCGG CGGCTGCGTG AGGCCTTCAA CTGAGGGCGC ACGCGGCCGG CCGAGTTCCG 240

GGCTGCGCAG CTCCAGGGCC TGGGCCACTT CCTTCAAGAA AACAAGCAGC TTCTGCGCGA 300 CGTGCTGGCC CAGGACCTGC ATAAGCCAGC TTTCGAGGCA GACATATCTG AGCTCATCCT 360

TTGCCAGAAC GAGGTTGACT ACGCTCTCAA GAACCTTCAG GCCTGGATGA AGGATGAACC 420

ACGGTCCACG AACCTGTTCA TGAAGCTGGA CTCGGTCTTC ATCTGGAAGG AACCCTTTGG 480

CCTGGTCCTC ATCATCGCAC CCTGGAACTA CCCATTGAAC CTGACCCTGG TGCTCCTGGT 540 GGGCACCCTC CCCGCAGGGA ATTGCGTGGT GCTGAAGCCG TCAGAAATCA GCCAGGGCAC 600

AGAGAAGGTC CTGGCTGAGG TGCTGCCCCA GTACCTGGAC CAGAGCTGCT TTGCCGTGGT 660

GCTGGGCGGA CCCCAGGAGA CAGGGCAGCT GCTAGAGCAC AAGTTGGACT ACATCTTCTT 720

CACAGGGAGC CCTCGTGTGG GCAAGATTGT CATGACTGCT GCCACCAAGC ACCTGACGCC 780

TGTCACCCTG GAGCTGGGGG GCAAGAACCC CTGCTACGTG GACGACAACT GCGACCCCCA 840 GACCGTGGCC AACCGCGTGG CCTGGTTCTG CTACTTCAAT GCCGGCCAGA CCTGCGTGGC 900

CCCTGACTAC GTCCTGTGCA GCCCCGAGAT GCAGGAGAGG CTGCTGCCCG CCCTGCAGAG 960

CACCATCACC CGTTTCTATG GCGACGACCC CCAGAGCTCC CCAAACCTGG GCCGCATCAT 1020

CAACCAGAAA CAGTTCCAGC GGCTGCGGGC ATTGCTGGGC TGCGGCCGCG TGGCCATTGG 1080

GGGCCAGAGC AACGAGAGCG ATCGCTACAT CGCCCCCACG GTGCTGGTGG ACGTGCAGGA 1140 GACGGAGCCT GTGATGCAGG AGGAGATCTT CGGGCCCATC CTGCCCATCG TGAACGTGCA 1200

GAGCGTGGAC GAGGCCATCA AGTTCATCAA CCGGCAGGAG AAGCCCCTGG CCCTGTACGC 1260

CTTCTCCAAC AGCAGACAGG TTGTGAACCA GATGCTGGAG CGGACCAGCA GCGGCAGCTT 1320

TGGAGGCAAT GAGGGCTTCA CCTACATATC TCTGCTGTCC GTGCCATTCG GGGGAGTCGG 1380

CCACAGTGGG ATGGGCCGGT ACCACGGCAA GTTCACCTTC GACACCTTCT CCCACCACCG 1440 CACCTGCCTG CTCGCCCCCT CCGGCCTGGA GAAATTAAAG GAGATCCGCT ACCCACCCTA 1500

TACCGACTGG AACCAGCAGC TGTTACGCTG GGGCATGGGC TCCCAGAGCT GCACCCTCCT 1560

GTGAGCGTCC CACCCGCCTC CAACGGGTCA CACAGAGAAA CCTGAGTCTA GCCATGAGGG 1620

GCTTATGCTC CCAACTCACA TTGTTCCTCC AGACCGCAGG CTCCCCCAGC CTCAGGTTGC 1680

TGGAGCTGTC ACATGACTGC ATCCTGCCTG CCAGGGCTGC AAAGCAAGGT CTTGCTTCTA 1740 TCTGGGGGAC GCTGCTCGAG AGAGGCCGAG AGGCCGCAGA ACATGCCAGG TGTCCTCACT 1800

CACCCCACCC TCCCCAATTC CAGCCCTTTG CCCTCTCGGT CAGGGTTGGC CAGGCCCAGT 1860

CACAGGGGCA GTGTCACCCT GGAAAATACA GTGCCCTGCC TTCTTAGGGG CATCAGCCCT 1920

GAACGGTTGA GAGCGTGGAG CCCTCCAGGC CTTTGCTCTC CCCTCTAGGC ACACGCGCAC 1980

TTCCACCTCT GCCCCATCCC AACTGCACCA GCACTGCCTC CCCCAGGGAT CCTCTCACAT 2040 CCCACACTGG TCTCTGCACC ACCCCTCTGG TTCACACCGC ACCCTGCACT CACCCACAGC 2100

AGCTCCATCC ACTGGGAAAA CTGGGGTTTG CATCACTCCA CTGCACAGTG TTAGTGGGAC 2160

CTGGGGGCAA GTCCCTTGAC TTCTCTGAGC CTCAGTTTCC TTATGTGAAA GTTGCTGGAA 2220

CCAAAATGGA GTCACTTATG CCAAACTCTA ATAAAATGGA GTCGGGGGGG CACATAGAAG 2280

CCCTCACACA CACATGCCCG TAACAGGATT TATCACCAAG ACACGCCTGC ATGTAAGACC 2340 AGACACAGGG CGTATGGAAA AGCACGTCCT CAAAGACTGT AGTATTCCAG ATGAGCTGCA 2400

GATGCTTACC TACCACGGCC GTCTCCACCA GAAAACCATC GCCAACTCCT GCGATCAGCT 2460

TGTGACTTAC AAACCTTGTT TAAAAGCTGC TTACATGGAC TTCTGTCCTT TAAAACGTTC 2520

CCCTTGGCTG TGGCCCTCTG TGTATGCCTG GGATCCTTCC AAGCACTCAT AGCCCAGATA 2580

GGAATCCTCT GCTCCTCCCA AATAAATTCA TCTGTTC

Seq ID NO: 111 Protein sequence: Protein Accession #: NP_000686

1 11 21 31 41 51

MKDEPRSTNL FMKLDSVFIW KEPFGLVLII APWNYPLNLT LVLLVGTLPA GNCWLKPSE 60

ISQGTEKVLA EVLPQYLDQS CFAWLGGPQ ETGQLLEHKL DYIFFTGSPR VGKIVMTAAT 120

KHLTPVTLEL GGKNPCYVDD NCDPQTVANR VAWFCYFNAG QTCVAPDYVL CSPEMQERLL 180 PALQSTITRP YGDDPQSSPN LGRIINQKQF QRLRALLGCG RVAIGGQSNE SDRYIAPTVL 240

VDVQETEPVM QEEIFGPILP IVNVQSVDEA IKFINRQEKP LALYAFSNSR QWNQMLERT 300

SSGSFGGNEG FTYISLLSVP FGGVGHSGMG RYHGKFTFDT FSHHRTCLLA PSGLEKLKEI 360 RYPPYTDWNQ QLLRWGMGSQ SCTLL Seq ID NO: 112 DNA sequence

Nucleic Acid Accession #: NM_004456 Coding sequence: 58-2298

1 11 21 31 41 51 i i i i i i

GAATTCCGGG CGACGCGCGG GAACAACGCG AGTCGGCGCG CGGGACGAAG AATAATCATG 60

GGCCAGACTG GGAAGAAATC TGAGAAGGGA CCAGTTTGTT GGCGGAAGCG TGTAAAATCA 120

GAGTACATGC GACTGAGACA GCTCAAGAGG TTCAGACGAG CTGATGAAGT AAAGAGTATG 180

TTTAGTTCCA ATCGTCAGAA AATTTTGGAA AGAACGGAAA TCTTAAACCA AGAATGGAAA 240 CAGCGAAGGA TACAGCCTGT GCACATCCTG ACTTCTGTGA GCTCATTGCG CGGGACTAGG 300

GAGTGTTCGG TGACCAGTGA CTTGGATTTT CCAACACAAG TCATCCCATT AAAGACTCTG 360

AATGCAGTTG CTTCAGTACC CATAATGTAT TCTTGGTCTC CCCTACAGCA GAATTTTATG 420

GTGGAAGATG AAACTGTTTT ACATAACATT CCTTATATGG GAGATGAAGT TTTAGATCAG 480

GATGGTACTT TCATTGAAGA ACTAATAAAA AATTATGATG GGAAAGTACA CGGGGATAGA 540 GAATGTGGGT TTATAAATGA TGAAATTTTT GTGGAGTTGG TGAATGCCCT TGGTCAATAT 600

AATGATGATG ACGATGATGA TGATGGAGAC GATCCTGAAG AAAGAGAAGA AAAGCAGAAA 660

GATCTGGAGG ATCACCGAGA TGATAAAGAA AGCCGCCCAC CTCGGAAATT TCCTTCTGAT 720

AAAATTTTGG AGGCCATTTC CTCAATGTTT CCAGATAAGG GCACAGCAGA AGAACTAAAG 780

GAAAAATATA AAGAACTCAC CGAACAGCAG CTCCCAGGCG CACTTCCTCC TGAATGTACC 840 CCCAACATAG ATGGACCAAA TGCTAAATCT GTTCAGAGAG AGCAAAGCTT ACACTCCTTT 900

CATACGCTTT TCTGTAGGCG ATGTTTTAAA TATGACTGCT TCCTACATCC TTTTCATGCA 960

ACACCCAACA CTTATAAGCG GAAGAACACA GAAACAGCTC TAGACAACAA ACCTTGTGGA 1020

CCACAGTGTT ACCAGCATTT GGAGGGAGCA AAGGAGTTTG CTGCTGCTCT CACCGCTGAG 1080

CGGATAAAGA CCCCACCAAA ACGTCCAGGA GGCCGCAGAA GAGGACGGCT TCCCAATAAC 1140 AGTAGCAGGC CCAGCACCCC CACCATTAAT GTGCTGGAAT CAAAGGATAC AGACAGTGAT 1200

AGGGAAGCAG GGACTGAAAC GGGGGGAGAG AACAATGATA AAGAAGAAGA AGAGAAGAAA 1260

GATGAAACTT CGAGCTCCTC TGAAGCAAAT TCTCGGTGTC AAACACCAAT AAAGATGAAG 1320

CCAAATATTG AACCTCCTGA GAATGTGGAG TGGAGTGGTG CTGAAGCCTC AATGTTTAGA 1380

GTCCTCATTG GCACTTACTA TGACAATTTC TGTGCCATTG CTAGGTTAAT TGGGACCAAA 1440 ACATGTAGAC AGGTGTATGA GTTTAGAGTC AAAGAATCTA GCATCATAGC TCCAGCTCCC 1500

GCTGAGGATG TGGATACTCC TCCAAGGAAA AAGAAGAGGA AACACCGGTT GTGGGCTGCA 1560

CACTGCAGAA AGATACAGCT GAAAAAGGAC GGCTCCTCTA ACCATGTTTA CAACTATCAA 1620 CCCTGTGATC ATCCACGGCA GCCTTGTGAC AGTTCGTGCC CTTGTGTGAT AGCACAAAAT 1680 TTTTGTGAAA AGTTTTGTCA ATGTAGTTCA GAGTGTCAAA ACCGCTTTCC GGGATGCCGC 1740 TGCAAAGCAC AGTGCAACAC CAAGCAGTGC CCGTGCTACC TGGCTGTCCG AGAGTGTGAC 1800 CCTGACCTCT GTCTTACTTG TGGAGCCGCT GACCATTGGG ACAGTAAAAA TGTGTCCTGC 1860 AAGAACTGCA GTATTCAGCG GGGCTCCAAA AAGCATCTAT TGCTGGCACC ATCTGACGTG 1920 GCAGGCTGGG GGATTTTTAT CAAAGATCCT GTGCAGAAAA ATGAATTCAT CTCAGAATAC 1980 TGTGGAGAGA TTATTTCTCA AGATGAAGCT GACAGAAGAG GGAAAGTGTA TGATAAATAC 2040 ATGTGCAGCT TTCTGTTCAA CTTGAACAAT GATTTTGTGG TGGATGCAAC CCGCAAGGGT 2100 AACAAAATTC GTTTTGCAAA TCATTCGGTA AATCCAAACT GCTATGCAAA AGTTATGATG 2160 GTTAACGGTG ATCACAGGAT AGGTATTTTT GCCAAGAGAG CCATCCAGAC TGGCGAAGAG 2220 CTGTTTGTTG ATTACAGATA CAGCCAGGCT GATGCCCTGA AGTATGTCGG CATCGAAAGA 2280 GAAATGGAAA TCCCTTGACA TCTGCTACCT CCTCCCCCTC CTCTGAAACA GCTGCCTTAG 2340 CTTCAGGAAC CTCGAGTACT GTGGGCAATT TAGAAAAAGA ACATGCAGTT TGAAATTCTG 2400 AATTTGCAAA GTACTGTAAG AATAATTTAT AGTAATGAGT TTAAAAATCA ACTTTTTATT 2460 GCCTTCTCAC CAGCTGCAAA GTGTTTTGTA CCAGTGAATT TTTGCAATAA TGCAGTATGG 2520 TACATTTTTC AACTTTGAAT AAAGAATACT TGAACTTGAA AAAAAAAAAA AAAAAA

Seq ID NO: 113 Protein sequence: Protein Accession #: NP 004447

31

MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL ERTEILNQEW 60

KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT LNAVASVPIM YSWSPLQQNF 120

MVEDETVLHN IPYMGDEVLD QDGTFIEELI KNYDGKVHGD RECGFINDEI FVELVNALGQ 180

YNDDDDDDDG DDPEEREEKQ KDLEDHRDDK ESRPPRKFPS DKILEAISSM FPDKGTAEEL 240

KEKYKELTEQ QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHPFH 300

ATPNTYKRKN TETALDNKPC GPQCYQHLEG AKEFAAALTA ERIKTPPKRP GGRRRGRLPN 360

NSSRPSTPTI NVLESKDTDS DREAGTETGG ENNDKEEEEK KDETSSSSEA NSRCQTPIKM 420

KPNIEPPENV EWSGAEASMF RVLIGTYYDN FCAIARLIGT KTCRQVYEFR VKESSIIAPA 480

PAEDVDTPPR KKKRKHRLWA AHCRKIQLKK DGSSNHVYNY QPCDHPRQPC DSSCPCVIAQ 540

NFCEKFCQCS SECQNRFPGC RCKAQCNTKQ CPCYLAVREC DPDLCLTCGA ADHWDSKNVS 600

CKNCSIQRGS KKHLLLAPSD VAGWGIFIKD PVQKNEFISE YCGEIISQDE ADRRGKVYDK 660

YMCSFLFNLN NDFWDATRK GNKIRFANHS VNPNCYAKVM MVNGDHRIGI FAKRAIQTGE 720

ELFVDYRYSQ ADALKYVGIE REMEIP

Seq ID NO: 114 DNA sequence Nucleic Acid Accession #: NM_001827 Coding sequence: 96-335

11 21 31

AGTCTCCGGC GAGTTGTTGC CTGGGCTGGA CGTGGTTTTG TCTGCTGCGC CCGCTCTTCG 60

CGCTCTCGTT TCATTTTCTG CAGCGCGCCA CGAGGATGGC CCACAAGCAG ATCTACTACT 120

CGGACAAGTA CTTCGACGAA CACTACGAGT ACCGGCATGT TATGTTACCC AGAGAACTTT 180

CCAAACAAGT ACCTAAAACT CATCTGATGT CTGAAGAGGA GTGGAGGAGA CTTGGTGTCC 240

AACAGAGTCT AGGCTGGGTT CATTACATGA TTCATGAGCC AGAACCACAT ATTCTTCTCT 300

TTAGACGACC TCTTCCAAAA GATCAACAAA AATGAAGTTT ATCTGGGGAT CGTCAAATCT 360

TTTTCAAATT TAATGTATAT GTGTATATAA GGTAGTATTC AGTGAATACT TGAGAAATGT 420

ACAAATCTTT CATCCATACC TGTGCATGAG CTGTATTCTT CACAGCAACA GAGCTCAGTT 480

AAATGCAACT GCAAGTAGGT TACTGTAAGA TGTTTAAGAT AAAAGTTCTT CCAGTCAGTT 540

TTTCTCTTAA GTGCCTGTTT GAGTTTACTG AAACAGTTTA CTTTTGTTCA ATAAAGTTTG 600

TATGTTGCAT TTAAAAAAAA AAAAAAA

Seq ID NO: 115 Protein sequence: Protein Accession ft: NP 001818 1 11 21 31 41 51 i i i i i i

MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ SLGWVHYMIH EPEPHILLFR RPLPKDQQK

Seq ID NO: 116 DNA sequence

Nucleic Acid Accession #: CAT cluster

31

TCAGACCTCA TGAGTCACTT GGACTCTTGA GCCACCTCTG GGGGTGGAGT CTCTCTCCTG 60

GCATCTGGAC CCTTGGTGCT ATCGACGAAG CTTGGGTGGG GCTCTTAGCT GCTATGTGCA 120

AGAGGTGTGT TCCAGGGAAA GCCCCTATCT CTCTGCAGAG GTCAAGTGAA AGCGACGGCC 180

GCAGCCAACA GAGTTCAAAA TGCAGGCTTG GAAAGTACAG GGGGCTCTGT GGAGGATGGG 240

AAGGACTGAT CCACATTCCC ACCAGGAAGT TTAGCAGAAC CCCCGCGTGC CAACTGGACC 300

CCTTGGAAGG ACCTGGCTCA GGCTGGACCA CCTCTTGAGA GGGAGGAGCT CTGGATTTGA 360

TCAAGAATTC TTTGCTGAGC ATGGTGCCTC ATGCCTATAA TACCAACACT TTGGGAGGCC 420

AGTGTGGGAG GATCTCTTGA GCCCAGGAGT TCAAGACTAG CCTGGGCAAC ACAGAGAGAA 480

CCCATCTCTA AAATAATAAT AATAATAAAA TAAAAAATTA GCAGGGCATG GTGGCATGTG 540

CCTGTAGTTC CAGCTACCCA GGAGGCTGAG GCAAGAGGAT GGCTGGAGCC TGGGATGTTG 600

AGGCTGCAAT GAACTGTGAT TACCCCACTG CACTCCAGCC TGGGCAAAAG AGCGAGAGAA 660

CCTGTCTCAA ATAATAATAA TAATAATAAT CTTATTTTGG AGAATAAAGA GACCTCTGGA 720

TTTGAGGTGC CATTTGGGTA GAAAGAAAAG ACGTTTACAC CGAGAAATAG TCTGTGTTGC 780

CCTGAAGGAG CAGAGGGATG CATCGCTGGA GGTGACCTAC AGTTGAAGAA GACTCATTAT 840

GACAGACCTT GTCCTTCTTC CTTGTGGAAA GTGTTTCCTC TGCTGCTACT GCTCATGAGA 900

CTCTTCCCCC TCCCTGTCCC AGGGAACCAA AGGGCTTTCT ACCACACCCT TTCTTGCCCC 960

CCGCCTCCCA TGTCTGCTGT GCCTTTGTAC TCAGCAATTC TTGTTTGCTC CATTATCTTC 1020

CAGCCGGATA CAGAGTGAAT AGTTAACCAC ACTTAGGTCA AATAGGATCT AAATTTTTGT 1080

TCCTGCTCCG TGTAAAGAGG CCAGTGTTTG TGTGTTGCAA GCAGCCTTGG AATAGTAACT 1140 CTTCTCATTT GTTTGGGATC TGGCCACCAA GTTCCAGAAT GATACACGGA TCAGTGCAGA. 1200

AGTTCATCAG GCTCTCGGAC CTTAGGGCTG TTGGAGAAGG CTTCAGCAGC AGAACTGATG 1260

GTGAAGGCTC GTGTTCTCCA TCCTCAACTT TCTTTGCTTC GATCATACAC AAGAATACAT 1320

TTGGAAGGGC AAAAAATGAA CACTGTCGTT CATTGCAGCC GTGTTTTGTG ACACAGATGC 1380

ACAGTCTGCT GTGAAGACCT TCTCTCAAGT GGCATTTGGG AGTCCATGCC AGATCATGGT 1440

GCTTCATGAG AGACTGACAG CTATCAGGGG TTGTGGCACT TAGTGAGGAC TCTCCTCCCC 1500

CAGTGTGTGC TGATGACACA TACACACCTG ACAATAGCTT GAGTCTTCTC TGTTCCTTTT 1560

ACTCTGTAGC CAACATACAC ATGATTTAAA ACCCTTTCTA AATATCTATC ATGGTTCATC 1620

CTTGTCCAAA TGCAGAGTCA GAGCTATTTG TACTTCATTA TTATTTCCAA GGCGAATAGT 1680

TGGCTTTCTT TTTGCAAAAA TAATTAAAGT TTTTGTATGT TGCAAAAAAA AAAAAAAAAA 1740 AAACAAAAAA

Seq ID NO: 117 DNA sequence

Nucleic Acid Accession #: BC012178.1

Coding sequence: 204-2285

11 21 31 41 51

CTTCTCTCCC GCGGCGCTGG GGCCCGCGCT CCGCTGCTGT TGCTCCATTC GGCGCTTTTC 60 TGGCGGCTGG CTCCTCTCCG CTGCCGGCTG CTCCTCGACC AGGCCTCCTT CTCAACCTCA 120 GCCCGCGGCG CCGACCCTTC CGGCACCCTC CCGCCCCGTC TCGTACTGTC GCCGTCACCG 180 CCGCGGCTCC GGCCCTGGCC CCGATGGCTC TGTGCAACGG AGACTCCAAG CTGGAGAATG 240 CTGGAGGAGA CCTTAAGGAT GGCCACCACC ACTATGAAGG AGCTGTTGTC ATTCTGGATG 300 CTGGTGCTCA GTACGGGAAA GTCATAGACC GAAGAGTGAG GGAACTGTTC GTGCAGTCTG 360 AAATTTTCCC CTTGGAAACA CCAGCATTTG CTATAAAGGA ACAAGGATTC CGTGCTATTA 420 TCATCTCTGG AGGACCTAAT TCTGTGTATG CTGAAGATGC TCCCTGGTTT GATCCAGCAA 480 TATTCACTAT TGGCAAGCCT GTTCTTGGAA TTTGCTATGG TATGCAGATG ATGAATAAGG 540 TATTTGGAGG TACTGTGCAC AAAAAAAGTG TCAGAGAAGA TGGAGTTTTC AACATTAGTG 600 TGGATAATAC ATGTTCATTA TTCAGGGGCC TTCAGAAGGA AGAAGTTGTT TTGCTTACAC 660 ATGGAGATAG TGTAGACAAA GTAGCTGATG GATTCAAGGT TGTGGCACGT TCTGGAAACA 720 TAGTAGCAGG CATAGCAAAT GAATCTAAAA AGTTATATGG AGCACAGTTC CACCCTGAAG 780 TTGGCCTTAC AGAAAATGGA AAAGTAATAC TGAAGAATTT CCTTTATGAT ATAGCTGGAT 840 GCAGTGGAAC CTTCACCGTG CAGAACAGAG AACTTGAGTG TATTCGAGAG ATCAAAGAGA 900 GAGTAGGCAC GTCAAAAGTT TTGGTTTTAC TCAGTGGTGG AGTAGACTCA ACAGTTTGTA 960 CAGCTTTGCT AAATCGTGCT TTGAACCAAG AACAAGTCAT TGCTGTGCAC ATTGATAATG 1020 GCTTTATGAG AAAACGAGAA AGCCAGTCTG TTGAAGAGGC CCTCAAAAAG CTTGGAATTC 1080 AGGTCAAAGT GATAAATGCT GCTCATTCTT TCTACAATGG AACAACAACC CTACCAATAT 1140 CAGATGAAGA TAGAACCCCA CGGAAAAGAA TTAGCAAAAC GTTAAATATG ACCACAAGTC 1200 CTGAAGAGAA AAGAAAAATC ATTGGGGATA CTTTTGTTAA GATTGCCAAT GAAGTAATTG 1260 GAGAAATGAA CTTGAAACCA GAGGAGGTTT TCCTTGCCCA AGGTACTTTA CGGCCTGATC 1320 TAATTGAAAG TGCATCCCTT GTTGCAAGTG GCAAAGCTGA ACTCATCAAA ACCCATCACA 1380 ATGACACAGA GCTCATCAGA AAGTTGAGAG AGGAGGGAAA AGTAATAGAA CCTCTGAAAG 1440 ATTTTCATAA AGATGAAGTG AGAATTTTGG GCAGAGAACT TGGACTTCCA GAAGAGTTAG 1500 TTTCCAGGCA TCCATTTCCA GGTCCTGGCC TGGCAATCAG AGTAATATGT GCTGAAGAAC 1560 CTTATATTTG TAAGGACTTT CCTGAAACCA ACAATATTTT GAAAATAGTA GCTGATTTTT 1620 CTGCAAGTGT TAAAAAGCCA CATACCCTAT TACAGAGAGT CAAAGCCTGC ACAACAGAAG 1680 AGGATCAGGA GAAGCTGATG CAAATTACCA GTCTGCATTC ACTGAATGCC TTCTTGCTGC 1740 CAATTAAAAC TGTAGGTGTG CAGGGTGACT GTCGTTCCTA CAGTTACGTG TGTGGAATCT 1800 CCAGTAAAGA TGAACCTGAC TGGGAATCAC TTATTTTTCT GGCTAGGCTT ATACCTCGCA 1860 TGTGTCACAA CGTTAACAGA GTTGTTTATA TATTTGGCCC ACCAGTTAAA GAACCTCCTA 1920 CAGATGTTAC TCCCACTTTC TTGACAACAG GGGTGCTCAG TACTTTACGC CAAGCTGATT 1980 TTGAGGCCCA TAACATTCTC AGGGAGTCTG GGTATGCTGG GAAAATCAGC CAGATGCCGG 2040 TGATTTTGAC ACCATTACAT TTTGATCGGG ACCCACTTCA AAAGCAGCCT TCATGCCAGA 2100 GATCTGTGGT TATTCGAACC TTTATTACTA GTGACTTCAT GACTGGTATA CCTGCAACAC 2160 CTGGCAATGA GATCCCTGTA GAGGTGGTAT TAAAGATGGT CACTGAGATT AAGAAGATTC 2220 CTGGTATTTC TCGAATTATG TATGACTTAA CATCAAAGCC CCCAGGAACT ACTGAGTGGG 2280 AGTAATAAAC TTCTTGTTCT ATTAAAA

Seq ID NO: 118 Protein sequence: Protein Accession #: AAH12178.1

11 21 31 41 51

MALCNGDSKL I

ENAGGDLKDG H IHHYEGAWI L IDAGAQYGKV I IDRRVRELFV Q ISEIFPLETP 60 AFAIKEQGFR AIIISGGPNS VYAEDAPWFD PAIFTIGKPV LGICYGMQMM NKVFGGTVHK 120 KSVREDGVFN ISVDNTCSLF RGLQKEEWL LTHGDSVDKV ADGFKWARS GNIVAGIANE 180 SKKLYGAQFH PEVGLTENGK VILKNFLYDI AGCSGTFTVQ NRELECIREI KERVGTSKVL 240 VLLSGGVDST VCTALLNRAL NQEQVIAVHI DNGFMRKRES QSVEEALKKL GIQVKVINAA 300 HSFYNGTTTL PISDEDRTPR KRISKTLNMT TSPEEKRKII GDTFVKIANE VIGEMNLKPE 360 EVFLAQGTLR PDLIESASLV ASGKAELIKT HHNDTELIRK LREEGKVIEP LKDFHKDEVR 420 I GRELGLPE ELVSRHPFPG PGLAIRVICA EEPYICKDFP ETNNILKIVA DFSASVKKPH 480 TLLQRVKACT TEEDQEKLMQ ITSLHSLNAF LLPIKTVGVQ GDCRSYSYVC GISSKDEPDW 540 ESLIFLARLI PRMCHNVNRV VYIFGPPVKE PPTDVTPTFL TTGVLSTLRQ ADFEAHNILR 600 ESGYAGKISQ MPVILTPLHF DRDPLQKQPS CQRSWIRTF ITSDFMTGIP ATPGNEIPVE 660 WLKMVTEIK KIPGISRIMY DLTSKPPGTT EWE

Seq ID NO: 119 DNA sequence Nucleic Acid Accession #: NM_006500.1 Coding sequence: 27..1967

1 11 21 31 41 51

I I I I I I

ACTTGCGTCT CGCCCTCCGG CCAAGCATGG GGCTTCCCAG GCTGGTCTGC GCCTTCTTGC 60 TCGCCGCCTG CTGCTGCTGT CCTCGCGTCG CGGGTGTGCC CGGAGAGGCT GAGCAGCCTG 120

CGCCTGAGCT GGTGGAGGTG GAAGTGGGCA GCACAGCCCT TCTGAAGTGC GGCCTCTCCC 180

AGTCCCAAGG CAACCTCAGC CATGTCGACT GGTTTTCTGT CCACAAGGAG AAGCGGACGC 240 TCATCTTCCG TGTGCGCCAG GGCCAGGGCC AGAGCGAACC TGGGGAGTAC GAGCAGCGGC 300

TCAGCCTCCA GGACAGAGGG GCTACTCTGG CCCTGACTCA AGTCACCCCC CAAGACGAGC 360

GCATCTTCTT GTGCCAGGGC AAGCGCCCTC GGTCCCAGGA GTACCGCATC CAGCTCCGCG 420

TCTACAAAGC TCCGGAGGAG CCAAACATCC AGGTCAACCC CCTGGGCATC CCTGTGAACA 480

GTAAGGAGCC TGAGGAGGTC GCTACCTGTG TAGGGAGGAA CGGGTACCCC ATTCCTCAAG 540

TCATCTGGTA CAAGAATGGC CGGCCTCTGA AGGAGGAGAA GAACCGGGTC CACATTCAGT 600

CGTCCCAGAC TGTGGAGTCG AGTGGTTTGT ACACCTTGCA GAGTATTCTG AAGGCACAGC 660

TGGTTAAAGA AGACAAAGAT GCCCAGTTTT ACTGTGAGCT CAACTACCGG CTGCCCAGTG 720

GGAACCACAT GAAGGAGTCC AGGGAAGTCA CCGTCCCTGT TTTCTACCCG ACAGAAAAAG 780

TGTGGCTGGA AGTGGAGCCC GTGGGAATGC TGAAGGAAGG GGACCGCGTG GAAATCAGGT 840

GTTTGGCTGA TGGCAACCCT CCACCACACT TCAGCATCAG CAAGCAGAAC CCCAGCACCA 900

GGGAGGCAGA GGAAGAGACA ACCAACGACA ACGGGGTCCT GGTGCTGGAG CCTGCCCGGA 960

AGGAACACAG TGGGCGCTAT GAATGTCAGG CCTGGAACTT GGACACCATG ATATCGCTGC 1020

TGAGTGAACC ACAGGAACTA CTGGTGAACT ATGTGTCTGA CGTCCGAGTG AGTCCCGCAG 1080

CCCCTGAGAG ACAGGAAGGC AGCAGCCTCA CCCTGACCTG TGAGGCAGAG AGTAGCCAGG 1140

ACCTCGAGTT CCAGTGGCTG AGAGAAGAGA CAGACCAGGT GCTGGAAAGG GGGCCTGTGC 1200

TTCAGTTGCA TGACCTGAAA CGGGAGGCAG GAGGCGGCTA TCGCTGCGTG GCGTCTGTGC 1260

CCAGCATACC CGGCCTGAAC CGCACACAGC TGGTCAAGCT GGCCATTTTT GGCCCCCCTT 1320

GGATGGCATT CAAGGAGAGG AAGGTGTGGG TGAAAGAGAA TATGGTGTTG AATCTGTCTT 1380

GTGAAGCGTC AGGGCACCCC CGGCCCACCA TCTCCTGGAA CGTCAACGGC ACGGCAAGTG 1440

AACAAGACCA AGATCCACAG CGAGTCCTGA GCACCCTGAA TGTCCTCGTG ACCCGGGAGC 1500

TGTTGGAGAC AGGTGTTGAA TGCACGGCCT CCAACGACCT GGGCAAAAAC ACCAGCATCC 1560

TCTTCCTGGA GCTGGTCAAT TTAACCACCC TCACACCAGA CTCCAACACA ACCACTGGCC 1620

TCAGCACTTC CACTGCCAGT CCTCATACCA GAGCCAACAG CACCTCCACA GAGAGAAAGC 1680

TGCCGGAGCC GGAGAGCCGG GGCGTGGTCA TCGTGGCTGT GATTGTGTGC ATCCTGGTCC 1740

TGGCGGTGCT GGGCGCTGTC CTCTATTTCC TCTATAAGAA GGGCAAGCTG CCGTGCAGGC 1800

GCTCAGGGAA GCAGGAGATC ACGCTGCCCC CGTCTCGTAA GACCGAACTT GTAGTTGAAG 1860

TTAAGTCAGA TAAGCTCCCA GAAGAGATGG GCCTCCTGCA GGGCAGCAGC GGTGACAAGA 1920

GGGCTCCGGG AGACCAGGGA GAGAAATACA TCGATCTGAG GCATTAGCCC CGAATCACTT 1980

CAGCTCCCTT CCCTGCCTGG ACCATTCCCA GCTCCCTGCT CACTCTTCTC TCAGCCAAAG 2040

CCTCCAAAGG GACTAGAGAG AAGCCTCCTG CTCCCCTCAC CTGCACACCC CCTTTCAGAG 2100

GGCCACTGGG TTAGGACCTG AGGACCTCAC TTGGCCCTGC AAGCCGCTTT TCAGGGACCA 2160

GTCCACCAGC ATCTCCTCCA CGTTGAGTGA AGCTCATCCC AAGCAAGGAG CCCCAGTCTC 2220

CCGAGCGGGT AGGAGAGTTT CTTGCAGAAC GTGTTTTTTC TTTACACACA TTATGGCTGT 2280

AAATACCTGG CTCCTGCCAG CAGCTGAGCT GGGTAGCCTC TCTGAGCTGG TTTCCTGCCC 2340

CAAAGGCTGG CTTCCACCAT CCAGGTGCAC CACTGAAGTG AGGACACACC GGAGCCAGGC 2400

GCCTGCTCAT GTTGAAGTGC GCTGTTCACA CCCGCTCCGG AGAGCACCCC AGCGGCATCC 2460

AGAAGCAGCT GCAGTGTTGC TGCCACCACC CTCCTGCTCG CCTCTTCAAA GTCTCCTGTG 2520

ACATTTTTTC TTTGGTCAGA AGCCAGGAAC TGGTGTCATT CCTTAAAAGA TACGTGCCGG 2580

GGCCAGGTGT GGTGGCTCAC GCCTGTAATC CCAGCACTTT GGGAGGCCGA GGCGGGCGGA 2640

TCACAAAGTC AGGACGAGAC CATCCTGGCT AACACGGTGA AACCCTGTCT CTACTAAAAA 2700

TACAAAAAAA AATTAGCTAG GCGTAGTGGT TGGCACCTAT AGTCCCAGCT ACTCGGAAGG 2760

CTGAAGCAGG AGAATGGTAT GAATCCAGGA GGTGGAGCTT GCAGTGAGCC GAGACCGTGC 2820

CACTGCACTC CAGCCTGGGC AACACAGCGA GACTCCGTCT CGAGGAAAAA AAAAGAAAAG 2880

ACGCGTACCT GCGGTGAGGA AGCTGGGCGC TGTTTTCGAG TTCAGGTGAA TTAGCCTCAA 2940

TCCCCGTGTT CACTTGCTCC CATAGCCCTC TTGATGGATC ACGTAAAACT GAAAGGCAGC 3000

GGGGAGCAGA CAAAGATGAG GTCTACACTG TCCTTCATGG GGATTAAAGC TATGGTTATA 3060

TTAGCACCAA ACTTCTACAA ACCAAGCTCA GGGCCCCAAC CCTAGAAGGG CCCAAATGAG 3120

AGAATGGTAC TTAGGGATGG AAAACGGGGC CTGGCTAGAG CTTCGGGTGT GTGTGTCTGT 3180

CTGTGTGTAT GCATACATAT GTGTGTATAT ATGGTTTTGT CAGGTGTGTA AATTTGCAAA 3240

TTGTTTCCTT TATATATGTA TGTATATATA TATATGAAAA TATATATATA TATGAAAAAT 3300

AAAGCTTAAT TGTCCCAGAA AATCATACAT TGCTTTTTTA TTCTACATGG GTACCACAGG 3360

AACCTGGGGG CCTGTGAAAC TACAACCAAA AGGCACACAA AACCGTTTCC AGTTGGCAGC 3 20

AGAGATCAGG GGTTACCTCT GCTTCTGAGC AAATGGCTCA AGCTCTACCA GAGCAGACAG 3480

CTACCCTACT TTTCAGCAGC AAAACGTCCC GTATGACGCA GCACGAAGGG CCTGGCAGGC 3540 TGTTAGCAGG AGCTATGTCC CTTCCTATCG TTTCCGTCCA CTT

Seq ID NO 120 Protein sequence: Protem Accession #: NP 006491.1

1 11 21 31 41 51

I I I I I 1

MGLPRLVCAF LLAACCCCPR VAGVPGEAEQ PAPELVEVEV GSTALLKCGL SQSQGNLSHV 60

DWFSVHKEKR TLIFRVRQGQ GQSEPGEYEQ RLSLQDRGAT LALTQVTPQD ERIFLCQGKR 120

PRSQEYRIQL RVYKAPEEPN IQVNPLGIPV NSKEPEEVAT CVGRNGYPIP QVIWYKNGRP 180

LKEEKNRVHI QSSQTVESSG LYTLQSILKA QLVKEDKDAQ FYCELNYRLP SGNHMKESRE 240

VTVPVFYPTE KVWLEVEPVG MLKEGDRVEI RCLADGNPPP HFSISKQNPS TREAEEETTN 300

DNGVLVLEPA RKEHSGRYEC QAWNLDTMIS LLSEPQELLV NYVSDVRVSP AAPERQEGSS 360

LTLTCEAESS QDLEFQWLRE ETDQVLERGP VLQLHDLKRE AGGGYRCVAS VPSIPGLNRT 420

QLVKLAIFGP PWMAFKERKV WVKENMVLNL SCEASGHPRP TISWNVNGTA SEQDQDPQRV 480

LSTLNVLVTP ELLETGVECT ASNDLGKNTS ILFLELVNLT TLTPDSNTTT GLSTSTASPH 540

TRANSTSTER KLPEPESRGV VIVAVIVCIL VLAVLGAVLY FLYKKGKLPC RRSGKQEITL 600 PPSRKTELW EVKSDKLPEE MGLLQGSSGD KRAPGDQGEK YIDLRH

Seq ID NO: 121 DNA sequence Nucleic Acid Accession #: NM_018306 Coding sequence: 60-671

1 11 21 31 41 51

I I I I I I

ATAGTCTACA CAGAGCTCCC CTTGCTGCCC AGACAAGCTG AAGGACCACA GGAAAAGCCA 60

TGGAGACTTC AGCATCCTCC TCCCAGCCTC AGGACAACAG TCAAGTCCAC AGAGAAACAG 120

AAGATGTAGA CTATGGAGAG ACAGATTTCC ACAAGCAAGA CGGGAAGGCT GGACTCTTTT 180

CCCAAGAACA ATATGAGAGA AACAAGTCTT CTTCCTCCTC CTTCTCTTCC TCCTCATCCT 240

CCTCATCTTC TTCATCCTCC TCCTCCTCAG GTCCTGGGCA TGGGGAGCCT GACGTTTTGA 300 AGGATGAGCT TCAACTCTAT GGAGATGCTC CTGGAGAGGT GGTACCCTCT GGGGAATCAG 360

GACTCCGAAG GAGAGGCTCT GACCCAGCAA GTGGAGAAGT GGAGGCCTCT CAGTTAAGAA 420

GACTGAATAT AAAGAAAGAT GATGAGTTTT TCCATTTCGT CCTCCTGTGC TTTGCCATCG 480

GGGCCTTGCT GGTGTGTTAT CACTATTACG CAGACTGGTT CATGTCTCTT GGGGTCGGCC 540

TGCTCACCTT CGCCTCCCTG GAAACCGTTG GCATCTACTT CGGACTAGTG TACCGTATCC 600

ACAGCGTCCT CCAAGGCTTC ATCCCCCTCT TCCAGAAGTT TAGGCTGACA GGGTTCAGGA 660

AGACTGACTG AGGCCACTTC CAGGTGGGCA GCAGAGGCAG GCCCCAGTGT GACCACCACT 720

GCGACCCCTG AGCCCACAAG GGCAGAGCAG CATTCTGAGA GACGCACAGG AGACCAAGCC 780

AGACCAATAA ACAGAACACT TTTCCTTCCA TGTGGTCTGA ATGTTGGCAC CAGCCCGGGC 840

AGGGGCATCT CATTTGGGCA GTACTGCTGT GCAACCCAGC TGCAAGGATG GAAGGCAGAG 900

GGTGGGTGTG GGGCCTGAGG CTTCACAGTA CCTGGACCAG CAGGAAGATT CTGGGAGGTC 960

ACTGCTCTCA GAGGACAGCA AGGGACCCTG AGCTCTGCAA GCTGTGATCT GTCTGGGTTC 1020

ATGGTTTTTC TCAAATCCCA GGCTATCTGC ATGCGCTCTC AGGTGCTACC GAGCCATCCT 1080

GGGAGAGATG GATGGTCCAC TGCTTTGAGG CAGGGAGCCA TCGGGCTGGG GCCCCTTGGT 1140

GAACCTGATG CAGGTAAGAT GCTGAGGACT AAAACCATTT TTTTTGCACC CAAAAAAAAA 1200

GGCAGGAAAA TGATCATCAG AAACTAAATG GCAGCCAGGC ATGGGGGCTC ACGACTGTAA 1260

TCCTCGCACT TTGGGAGGCT CAGGCTAAGG GTCGCTTGAA GCTGAGAGTT CAAGACCAAC 1320

CTGGGCAACA TAGTGAGACC CCCATCTCTA CAATTTTTTT TTAATGACCA AATGTGGCGG 1380

TACATACCTG TACATACCTG CGGTTCCAGC TACTCAAGAG GCTGAGGCAG GAGGACTGCT 1440

TGAGCCCAGG AGTTCAGGGC TGCAGTGAGG TACGATCAAG CCACTGCACT CCAGCCTGGG 1500 CGACAGAGCA AGATCGTTTC TCTAAAATT

Seq ID NO: 122 Protein sequence: Protein Accession ft: NP 060776

1 11 21 31 41 51

I I I I I I

METSASSSQP QDNSQVHRET EDVDYGETDF HKQDGKAGLF SQEQYERNKS SSSSFSSSSS 60

SSSSSSSSSS GPGHGEPDVL KDELQLYGDA PGEWPSGES GLRRRGSDPA SGEVEASQLR 120

RLNIKKDDEF FHFVLLCFAI GALLVCYHYY ADWFMSLGVG LLTFASLETV GIYFGLVYRI 180 HSVLQGFIPL FQKFRLTGFR KTD

Seq ID NO: 123 DNA sequence Nucleic Acid Accession #: BC022542 Coding sequence: 243..896

1 11 21 31 41 51

I I I I I I

ACTTGGTCCC AGCCGATAAA TCTGGGGCAG CGCGCGGTAG GAGCTGCGGG CGGCCAGGCC 60

CCTTCCTGCG TCCGCACCTG GCCCCGCGCG CCCCTCTCGG GCGTCCGGCT TCCGGCGTCC 120

TGGCGGCTCG GGTGGCGGCG GTTCGGGCGG CCGCCTGGCT GCTCCTCGGG GCGGCGACGG 180

GGCTCACGCG CGGGCCCGCC ACGGCCTTCA CCGCCGCGCG CTCTGACGCC GGCATAAGGG 240

CCATGTGTTC TGAAATTATT TTGAGGCAAG AAGTTTTGAA AGATGGTTTC CACAOAGACC 300

TTTTAATCAA AGTGAAGTTT GGGGAAAGCA TTGAGGACTT GCACACGTGC CGTCTCTTAA 360

TTAAACAGGA CATTCCTGCA GGACTTTATG TGGATCCGTA TGAGTTGGCT TCATTACGAG 420

AGAGAAACAT AACAGAGGCA GTGATGGTTT CAGAAAATTT TGATATAGAG GCCCCTAACT 480

ATTTGTCCAA GGAGTCTGAA GTTCTCATTT ATGCCAGACG AGATTCACAG TGCATTGACT 540

GTTTTCAAGC CTTTTTGCCT GTGCACTGCC GCTATCATCG GCCGCACAGT GAAGATGGAG 600

AAGCCTCGAT TGTGGTCAAT AACCCAGATT TGTTGATGTT TTGTGACCAA GAGTTCCCGA 660

TTTTGAAATG CTGGGCTCAC TCAGAAGTGG CAGCCCCTTG TGCTTTGGAT AATGAGGATA 720

TATGCCAATG GAACAAGATG AAGTATAAAT CAGTATATAA GAATGTGATT CTACAAGTTC 780

CAGTGGGACT GACTGTACAT ACCTCTCTAG TATGTTCTGT GACTCTGCTC ATTACAATCC 840

TGTGCTCTAC ATTGATCCTT GTAGCAGTTT TCAAATATGG CCATTTTTCC CTATAAGTTT 900

TATGTAGTTA AATGCTTCCT AGAAACCTAA ATAAGATCTA TTAATTTCTG ACGAGAGGTG 960

TTCTTCTAGA ATTAATTACT TTTATCTTTT GTCTTCATTT GTGGCCAAAA TTATGTTTAC 1020

TAGAGGAAAT TTGGGATCAT TCTCAGCTAA TTCCAAAATG TAGTGCTCTA TTGCATGGAT 1080

CCTTGGTAAT CCTCAAGCAT CAGATGCCAT AAGGGGAAAC TTAATTCTGC TAAATTAATG 1140

TTTATTTTGT GAGAAGTGAC TTTATCTTCA TTTGGGGTAG AAAAATTATT TCTTTATGTA 1200

GTAGAGACAA ATTATTCTCA TTTTGCAAGT ACTTTCAATT TAAGCTACAA ATTGAGAAAA 1260

CCGTTATAAA TAAGAATAAA ATAGGCCAGG CACAGTGGCT CACACCTGTA ATCCCAGCAC 1320

TTTGGGAGGC CGAGGTGGGC GGATCACCAG AGGTCAAGAG TTTGAGACCA GCTTGGTGAA 1380

ACCCTGTCTC TACTAAAAAT ACAAAAGTTA GCTGGGGCTG GTGGTGGGCA TCTGTAGTCC 1440

CAGCTAATTG GAAGGGTGAG GCGGGAGGAT CGCTTGAACC TGGGAGGCGG AGGTTCCAGA 1500

GAGCCAAGAT CGCACCACTG CACTACAGCC TGGGCGACAG AACGAGACCC TGTCTCCAAA 1560

GGAAAAACAA AAAAGAAGAA TAAAATAATT TGGATGAAAA TCATGTTTAT TTAAATAGTA 1620

ATGTCATGAG ACTATTAAAG ATGTGCCAGA GTTTCAATGA AAATCATTAA AGTAGGACAG 1680

CTAAGAAATT AATATTAATA TAAAAATTAT TGATAATCTT AAATTATTGA TTATTCCTTA 1740

ACGCACTCCA TTCTCCTTTT ACATTTTATC ATGTTTCTTT TGAATATATG AATTGGCAAA 1800

GGACTTGATG AAACTGAGTA CTAAGATTTG GTACAGAGTA TGTCAGGAAG ACAACTCAGA 1860 TTGCCATTTT AAATAAAGTT GTACATGAAC AAAAAAAAAA AAAAAA

Seq ID NO: 124 Protein sequence: Protein Accession #: AAH22542

1 11 21 31 41 51

I I I I ^' ! I

MCSEIILRQE VLKDGFHRDL LIKVKFGESI EDLHTCRLLI KQDIPAGLYV DPYELASLRE 60

RNITEAVMVS ENFDIEAPNY LSKESEVLIY ARRDSQCIDC FQAFLPVHCR YHRPHSEDGE 120

ASIWNNPDL LMFCDQAGSR RMIRFRFDSF DKTIEFPILK CWAHSEVAAP CALENEDICQ 180 WNKMKYKSVY KNVILQVPVG LTVHTSLVCS VTLLITILCS KKKKK Seq ID NO: 125 DNA sequence Nucleic Acid Accession #: NM_004994.1 Coding sequence: 20..2143 1 11 21 31 41 51

I I I I I I

AGACACCTCT GCCCTCACCA TGAGCCTCTG GCAGCCCCTG GTCCTGGTGC TCCTGGTGCT 60

GGGCTGCTGC TTTGCTGCCC CCAGACAGCG CCAGTCCACC CTTGTGCTCT TCCCTGGAGA 120

CCTGAGAACC AATCTCACCG ACAGGCAGCT GGCAGAGGAA TACCTGTACC GCTATGGTTA 180

CACTCGGGTG GCAGAGATGC GTGGAGAGTC GAAATCTCTG GGGCCTGCGC TGCTGCTTCT 240

CCAGAAGCAA CTGTCCCTGC CCGAGACCGG TGAGCTGGAT AGCGCCACGC TGAAGGCCAT 300

GCGAACCCCA CGGTGCGGGG TCCCAGACCT GGGCAGATTC CAAACCTTTG AGGGCGACCT 360

CAAGTGGCAC CACCACAACA TCACCTATTG GATCCAAAAC TACTCGGAAG ACTTGCCGCG 420

GGCGGTGATT GACGACGCCT TTGCCCGCGC CTTCGCACTG TGGAGCGCGG TGACGCCGCT 480

CACCTTCACT CGCGTGTACA GCCGGGACGC AGACATCGTC ATCCAGTTTG GTGTCGCGGA 540

GCACGGAGAC GGGTATCCCT TCGACGGGAA GGACGGGCTC CTGGCACACG CCTTTCCTCC 600

TGGCCCCGGC ATTCAGGGAG ACGCCCATTT CGACGATGAC GAGTTGTGGT CCCTGGGCAA 660

GGGCGTCGTG GTTCCAACTC GGTTTGGAAA CGCAGATGGC GCGGCCTGCC ACTTCCCCTT 720

CATCTTCGAG GGCCGCTCCT ACTCTGCCTG CACCACCGAC GGTCGCTCCG ACGGCTTGCC 780

CTGGTGCAGT ACCACGGCCA ACTACGACAC CGACGACCGG TTTGGCTTCT GCCCCAGCGA 840

GAGACTCTAC ACCCGGGACG GCAATGCTGA TGGGAAACCC TGCCAGTTTC CATTCATCTT 900

CCAAGGCCAA TCCTACTCCG CCTGCACCAC GGACGGTCGC TCCGACGGCT ACCGCTGGTG 960

CGCCACCACC GCCAACTACG ACCGGGACAA GCTCTTCGGC TTCTGCCCGA CCCGAGCTGA 1020

CTCGACGGTG ATGGGGGGCA ACTCGGCGGG GGAGCTGTGC GTCTTCCCCT TCACTTTCCT 1080

GGGTAAGGAG TACTCGACCT GTACCAGCGA GGGCCGCGGA GATGGGCGCC TCTGGTGCGC 1140

TACCACCTCG AACTTTGACA GCGACAAGAA GTGGGGCTTC TGCCCGGACC AAGGATACAG 1200

TTTGTTCCTC GTGGCGGCGC ATGAGTTCGG CCACGCGCTG GGCTTAGATC ATTCCTCAGT 1260

GCCGGAGGCG CTCATGTACC CTATGTACCG CTTCACTGAG GGGCCCCCCT TGCATAAGGA 1320

CGACGTGAAT GGCATCCGGC ACCTCTATGG TCCTCGCCCT GAACCTGAGC CACGGCCTCC 1380

AACCACCACC ACACCGCAGC CCACGGCTCC CCCGACGGTC TGCCCCACCG GACCCCCCAC 1440

TGTCCACCCC TCAGAGCGCC CCACAGCTGG CCCCACAGGT CCCCCCTCAG CTGGCCCCAC 1500

AGGTCCCCCC ACTGCTGGCC CTTCTACGGC CACTACTGTG CCTTTGAGTC CGGTGGACGA 1560

TGCCTGCAAC GTGAACATCT TCGACGCCAT CGCGGAGATT GGGAACCAGC TGTATTTGTT 1620

CAAGGATGGG AAGTACTGGC GATTCTCTGA GGGCAGGGGG AGCCGGCCGC AGGGCCCCTT 1680

CCTTATCGCC GACAAGTGGC CCGCGCTGCC CCGCAAGCTG GACTCGGTCT TTGAGGAGCC 1740

GCTCTCCAAG AAGCTTTTCT TCTTCTCTGG GCGCCAGGTG TGGGTGTACA CAGGCGCGTC 1800

GGTGCTGGGC CCGAGGCGTC TGGACAAGCT GGGCCTGGGA GCCGACGTGG CCCAGGTGAC 1860

CGGGGCCCTC CGGAGTGGCA GGGGGAAGAT GCTGCTGTTC AGCGGGCGGC GCCTCTGGAG 1920

GTTCGACGTG AAGGCGCAGA TGGTGGATCC CCGGAGCGCC AGCGAGGTGG ACCGGATGTT 1980

CCCCGGGGTG CCTTTGGACA CGCACGACGT CTTCCAGTAC CGAGAGAAAG CCTATTTCTG 2040

CCAGGACCGC TTCTACTGGC GCGTGAGTTC CCGGAGTGAG TTGAACCAGG TGGACCAAGT 2100

GGGCTACGTG ACCTATGACA TCCTGCAGTG CCCTGAGGAC TAGGGCTCCC GTCCTGCTTT 2160

GCAGTGCCAT GTAAATCCCC ACTGGGACCA ACCCTGGGGA AGGAGCCAGT TTGCCGGATA 2220

CAAACTGGTA TTCTGTTCTG GAGGAAAGGG AGGAGTGGAG GTGGGCTGGG CCCTCTCTTC 2280 TCACCTTTGT TTTTTGTTGG AGTGTTTCTA ATAAACTTGG ATTCTCTAAC CTTT

Seq ID NO: 126 Protein sequence: Protein Accession #: NP 004985.1

1 11 21 31 41 51

I I I I I I

MSLWQPLVLV LLVLGCCFAA PRQRQSTLVL FPGDLRTNLT DRQLAEEYLY RYGYTRVAEM 60

RGESKSLGPA LLLLQKQLSL PETGELDSAT LKAMRTPRCG VPDLGRFQTF EGDLKWHHHN 120 ITYWIQNYSE DLPRAVIDDA FARAFALWSA VTPLTFTRVY SRDADIVIQF GVAEHGDGYP 180

FDGKDGLLAH AFPPGPGIQG DAHFDDDELW SLGKGVWPT RFGNADGAAC HFPFIFEGRS 240

YSACTTDGRS DGLPWCSTTA NYDTDDRFGF CPSERLYTRD GNADGKPCQF PFIFQGQSYS 300

ACTTDGRSDG YRWCATTANY DRDKLFGFCP TRADSTVMGG NSAGELCVFP FTFLGKEYST 360

CTSEGRGDGR LWCATTSNFD SDKKWGFCPD QGYSLFLVAA HEFGHALGLD HSSVPEALMY 420 PMYRFTEGPP LHKDDVNGIR HLYGPRPEPE PRPPTTTTPQ PTAPPTVCPT GPPTVHPSER 480

PTAGPTGPPS AGPTGPPTAG PSTATTVPLS PVDDACNVNI FDAIAEIGNQ LYLFKDGKYW 540

RFSEGRGSRP QGPFLIADKW PALPRKLDSV FEEPLSKKLF FFSGRQVWVY TGASVLGPRR 600

LDKLGLGADV AQVTGALRSG RGKMLLFSGR RLWRFDVKAQ MVDPRSASEV DRMFPGVPLD 660 THDVFQYREK AYFCQDRFYW RVSSRSELNQ VDQVGYVTYD ILQCPED

Seq ID NO: 127 DNA sequence Nucleic Acid Accession #: NM_004181 Coding sequence: 32-670

1 11 21 31 41 51

I I I I I I

GCAGAAATAG CCTAGGGAGA TCAACCCCGA GATGCTGAAC AAAGTGCTGT CCCGGCTGGG 60

GGTCGCCGGC CAGTGGCGCT TCGTGGACGT GCTGGGGCTG GAAGAGGAGT CTCTGGGCTC 120

GGTGCCAGCG CCTGCCTGCG CGCTGCTGCT GCTGTTTCCC CTCACGGCCC AGCATGAGAA 180

CTTCAGGAAA AAGCAGATTG AAGAGCTGAA GGGACAAGAA GTTAGTCCTA AAGTGTACTT 240

CATGAAGCAG ACCATTGGGA ATTCCTGTGG CACAATCGGA CTTATTCACG CAGTGGCCAA 300

TAATCAAGAC AAACTGGGAT TTGAGGATGG ATCAGTTCTG AAACAGTTTC TTTCTGAAAC 360

AGAGAAAATG TCCCCTGAAG ACAGAGCAAA ATGCTTTGAA AAGAATGAGG CCATACAGGC 420

AGCCCATGAT GCCGTGGCAC AGGAAGGCCA ATGTCGGGTA GATGACAAGG TGAATTTCCA 480

TTTTATTCTG TTTAACAACG TGGATGGCCA CCTCTATGAA CTTGATGGAC GAATGCCTTT 540

TCCGGTGAAC CATGGCGCCA GTTCAGAGGA CACCCTGCTG AAGGACGCTG CCAAGGTGTG 600

CAGAGAATTC ACCGAGCGTG AGCAAGGAGA AGTCCGCTTC TCTGCCGTGG CTCTCTGCAA 660

GGCAGCCTAA TGCTCTGTGG GAGGGACTTT GCTGATTTCC CCTCTTCCCT TCAACATGAA 720

AATATATACC CCCCATGCAG TCTAAAATGC TTCAGTACTT GTGAAACACA GCTGTTCTTC 780

TGTTCTGCAG ACACGCCTTC CCCTCAGCCA CACCCAGGCA CTTAAGCACA AGCAGAGTGC 840

ACAGCTGTCC ACTGGGCCAT TGTGGTGTGA GCTTCAGATG GTGAAGCATT CTCCCCAGTG 900

TATGTCTTGT ATCCGATATC TAACGCTTTA AATGGCTACT TTGGTTTCTG TCTGTAAGTT 960 AAGACCTTGG ATGTGGTTAT GTTGTCCTAA AGAATAAATT TTGCTGATAG TAGC

Seq ID NO: 128 Protein sequence: Protein Accession #: NP 004172 I I I I I I

MLNKVLSRLG VAGQWRFVDV LGLEEESLGS VPAPACALLL LFPLTAQHEN FRKKQIEELK 60

GQEVSPKVYF MKQTIGNSCG TIGLIHAVAN NQDKLGFEDG SVLKQFLSET EKMSPEDRAK 120

CFEKNEAIQA AHDAVAQEGQ CRVDDKVNFH FILFNNVDGH LYELDGRMPF PVNHGASSED 180 TLLKDAAKVC REFTEREQGE VRFSAVALCK AA

Seq ID NO: 129 DNA sequence Nucleic Acid Accession #: NM_000213 Coding sequence: 127-5385

1 11 21 31 41 51

I I I I 1 I

CGCCCGCGCG CTGCAGCCCC ATCTCCTAGC GGCAGCCCAG GCGCGGAGGG AGCGAGTCCG 60

CCCCGAGGTA GGTCCAGGAC GGGCGCACAG CAGCAGCCGA GGCTGGCCGG GAGAGGGAGG 120

AAGAGGATGG CAGGGCCACG CCCCAGCCCA TGGGCCAGGC TGCTCCTGGC AGCCTTGATC 180

AGCGTCAGCC TCTCTGGGAC CTTGGCAAAC CGCTGCAAGA AGGCCCCAGT GAAGAGCTGC 240

ACGGAGTGTG TCCGTGTGGA TAAGGACTGC GCCTACTGCA CAGACGAGAT GTTCAGGGAC 300

CGGCGCTGCA ACACCCAGGC GGAGCTGCTG GCCGCGGGCT GCCAGCGGGA GAGCATCGTG 360

GTCATGGAGA GCAGCTTCCA AATCACAGAG GAGACCCAGA TTGACACCAC CCTGCGGCGC 420

AGCCAGATGT CCCCCCAAGG CCTGCGGGTC CGTCTGCGGC CCGGTGAGGA GCGGCATTTT 480

GAGCTGGAGG TGTTTGAGCC ACTGGAGAGC CCCGTGGACC TGTACATCCT CATGGACTTC 540

TCCAACTCCA TGTCCGATGA TCTGGACAAC CTCAAGAAGA TGGGGCAGAA CCTGGCTCGG 600

GTCCTGAGCC AGCTCACCAG CGACTACACT ATTGGATTTG GCAAGTTTGT GGACAAAGTC 660

AGCGTCCCGC AGACGGACAT GAGGCCTGAG AAGCTGAAGG AGCCCTGGCC CAACAGTGAC 720

CCCCCCTTCT CCTTCAAGAA CGTCATCAGC CTGACAGAAG ATGTGGATGA GTTCCGGAAT 780

AAACTGCAGG GAGAGCGGAT CTCAGGCAAC CTGGATGCTC CTGAGGGCGG CTTCGATGCC 840

ATCCTGCAGA CAGCTGTGTG CACGAGGGAC ATTGGCTGGC GCCCGGACAG CACCCACCTG 900

CTGGTCTTCT CCACCGAGTC AGCCTTCCAC TATGAGGCTG ATGGCGCCAA CGTGCTGGCT 960

GGCATCATGA GCCGCAACGA TGAACGGTGC CACCTGGAGA CCACGGGCAC CTACACCCAG 1020

TACAGGACAC AGGACTACCC GTCGGTGCCC ACCCTGGTGC GCCTGCTCGC CAAGCACAAC 1080

ATCATCCCCA TCTTTGCTGT CACCAACTAC TCCTATAGCT ACTACGAGAA GCTTCACACC 1140

TATTTCCCTG TCTCCTCACT GGGGGTGCTG CAGGAGGACT CGTCCAACAT CGTGGAGCTG 1200

CTGGAGGAGG CCTTCAATCG GATCCGCTCC AACCTGGACA TCCGGGCCCT AGACAGCCCC 1260

CGAGGCCTTC GGACAGAGGT CACCTCCAAG ATGTTCCAGA AGACGAGGAC TGGGTCCTTT 1320

CACATCCGGC GGGGGGAAGT GGGTATATAC CAGGTGCAGC TGCGGGCCCT TGAGCACGTG 1380

GATGGGACGC ACGTGTGCCA GCTGCCGGAG GACCAGAAGG GCAACATCCA TCTGAAACCT 1440

TCCTTCTCCG ACGGCCTCAA GATGGACGCG GGCATCATCT GTGATGTGTG CACCTGCGAG 1500

CTGCAAAAAG AGGTGCGGTC AGCTCGCTGC AGCTTCAACG GAGACTTCGT GTGCGGACAG 1560

TGTGTGTGCA GCGAGGGCTG GAGTGGCCAG ACCTGCAACT GCTCCACCGG CTCTCTGAGT 1620

GACATTCAGC CCTGCCTGCG GGAGGGCGAG GACAAGCCGT GCTCCGGCCG TGGGGAGTGC 1680

CAGTGCGGGC ACTGTGTGTG CTACGGCGAA GGCCGCTACG AGGGTCAGTT CTGCGAGTAT 1740

GACAACTTCC AGTGTCCCCG CACTTCCGGG TTCCTCTGCA ATGACCGAGG ACGCTGCTCC 1800

ATGGGCCAGT GTGTGTGTGA GCCTGGTTGG ACAGGCCCAA GCTGTGACTG TCCCCTCAGC 1860

AATGCCACCT GCATCGACAG CAATGGGGGC ATCTGTAATG GACGTGGCCA CTGTGAGTGT 1920

GGCCGCTGCC ACTGCCACCA GCAGTCGCTC TACACGGACA CCATCTGCGA GATCAACTAC 1980

TCGGCGATCC ACCCGGGCCT CTGCGAGGAC CTACGCTCCT GCGTGCAGTG CCAGGCGTGG 2040

GGCACCGGCG AGAAGAAGGG GCGCACGTGT GAGGAATGCA ACTTCAAGGT CAAGATGGTG 2100

GACGAGCTTA AGAGAGCCGA GGAGGTGGTG GTGCGCTGCT CCTTCCGGG CGAGGATGAC 2160

GACTGCACCT ACAGCTACAC CATGGAAGGT GACGGCGCCC CTGGGCCCAA CAGCACTGTC 2220

CTGGTGCACA AGAAGAAGGA CTGCCCTCCG GGCTCCTTCT GGTGGCTCAT CCCCCTGCTC 2280

CTCCTCCTCC TGCCGCTCCT GGCCCTGCTA CTGCTGCTAT GCTGGAAGTA GTGTGCCTGC 2340

TGCAAGGCCT GCCTGGCACT TCTCCCGTGC TGCAACCGAG GTCACATGGT GGGCTTTAAG 2400

GAAGACCACT ACATGCTGCG GGAGAACCTG ATGGCCTCTG ACCACTTGGA CACGCCCATG 2460

CTGCGCAGCG GGAACCTCAA GGGCCGTGAC GTGGTCCGCT GGAAGGTCAC CAACAACATG 2520

CAGCGGCCTG GCTTTGCCAC TCATGCCGCC AGCATCAACC CCACAGAGCT GGTGCCCTAC 2580

GGGCTGTCCT TGCGCCTGGC CCGCCTTTGC ACCGAGAACC TGCTGAAGCC TGACACTCGG 2640

GAGTGCGCCC AGCTGCGCCA GGAGGTGGAG GAGAACCTGA ACGAGGTCTA CAGGCAGATC 2700

TCCGGTGTAC ACAAGCTCCA GCAGACCAAG TTCCGGCAGC AGCCCAATGC CGGGAAAAAG 2760

CAAGACCACA CCATTGTGGA CACAGTGCTG ATGGCGCCCC GCTCGGCCAA GCCGGCCCTG 2820

CTGAAGCTTA CAGAGAAGCA GGTGGAACAG AGGGCCTTCC ACGACCTCAA GGTGGCCCCC 2880

GGCTACTACA CCCTCACTGC AGACCAGGAC GCCCGGGGCA TGGTGGAGTT CCAGGAGGGC 2940

GTGGAGCTGG TGGACGTACG GGTGCCCCTC TTTATCCGGC CTGAGGATGA CGACGAGAAG 3000

CAGCTGCTGG TGGAGGCCAT CGACGTGCCC GCAGGCACTG CCACCCTCGG CCGCCGCCTG 3060

GTAAACATCA CCATCATCAA GGAGCAAGCC AGAGACGTGG TGTCCTTTGA GCAGCCTGAG 3120

TTCTCGGTCA GCCGCGGGGA CCAGGTGGCC CGCATCCCTG TCATCCGGCG TGTCCTGGAC 3180

GGCGGGAAGT CCCAGGTCTC CTACCGCACA CAGGATGGCA CCGCGCAGGG CAACCGGGAC 3240

TACATCCCCG TGGAGGGTGA GCTGCTGTTC CAGCCTGGGG AGGCCTGGAA AGAGCTGCAG 3300

GTGAAGCTCC TGGAGCTGCA AGAAGTTGAC TCCCTCCTGC GGGGCCGCCA GGTCCGCCGT 3360

TTCCACGTCC AGCTCAGCAA CCCTAAGTTT GGGGCCCACC TGGGCCAGCC CCACTCCACC 3420

ACCATCATCA TCAGGGACCC AGATGAACTG GACCGGAGCT TCACGAGTCA GATGTTGTCA 3480

TCACAGCCAC CCCCTCACGG CGACCTGGGC GCCCCGCAGA ACCCCAATGC TAAGGCCGCT 3540

GGGTCCAGGA AGATCCATTT CAACTGGCTG CCCCCTTCTG GCAAGCCAAT GGGGTACAGG 3600

GTAAAGTACT GGATTCAGGG TGACTCCGAA TCCGAAGCCC ACCTGCTCGA CAGCAAGGTG 3660

CCCTCAGTGG AGCTCAGCAA CCTGTACCCG TATTGCGACT ATGAGATGAA GGTGTGCGCC 3720

TACGGGGCTC AGGGCGAGGG ACCCTACAGC TCCCTGGTGT CCTGCCGCAC CCACCAGGAA 3780

GTGCCCAGCG AGCCAGGGCG TCTGGCCTTC AATGTCGTCT CCTCCACGGT GACCCAGCTG 3840

AGCTGGGCTG AGCCGGCTGA GACCAACGGT GAGATCACAG CCTACGAGGT CTGCTATGGC 3900

CTGGTCAACG ATGACAACCG ACCTATTGGG CCCATGAAGA AAGTGCTGGT TGACAACCCT 3960

AAGAACCGGA TGCTGCTTAT TGAGAACCTT CGGGAGTCCC AGCCCTACCG CTACACGGTG 4020

AAGGCGCGCA ACGGGGCCGG CTGGGGGCCT GAGCGGGAGG CCATCATCAA CCTGGCCACC 4080

CAGCCCAAGA GGCCCATGTC CATCCCCATC ATCCCTGACA TCCCTATCGT GGACGCCCAG 4140

AGCGGGGAGG ACTACGACAG CTTCCTTATG TACAGCGATG ACGTTCTACG CTCTCCATCG 4200

GGCAGCCAGA GGCCCAGCGT CTCCGATGAC ACTGAGCACC TGGTGAATGG CCGGATGGAC 4260

TTTGCCTTCC CGGGCAGCAC CAACTCCCTG CACAGGATGA CCACGACCAG TGCTGCTGCC 4320

TATGGCACCC ACCTGAGCCC ACACGTGCCC CACCGCGTGC TAAGCACATC CTCCACCCTC 4380 ACACGGGACT ACAACTCACT ACCCGCTCA GAACACTCAC ACTCGACCAC ACTGCCGAGG 4440

GACTACTCCA CCCTCACCTC CGTCTCCTCC CACGACTCTC GCCTGACTGC TGGTGTGCCC 4500

GACACGCCCA CCCGCCTGGT GTTCTCTGCC CTGGGGCCCA CATCTCTCAG AGTGAGCTGG 4560

CAGGAGCCGC GGTGCGAGCG GCCGCTGCAG GGCTACAGTG TGGAGTACCA GCTGCTGAAC 4620

GGCGGTGAGC TGCATCGGCT CAACATCCCC AACCCTGCCC AGACCTCGGT GGTGGTGGAA 4680

GACCTCCTGC CCAACCACTC CTACGTGTTC CGCGTGCGGG CCCAGAGCCA GGAAGGCTGG 4740

GGCCGAGAGC GTGAGGGTGT CATCACCATT GAATCCCAGG TGCACCCGCA GAGCCCACTG 4800

TGTCCCCTGC CAGGCTCCGC CTTCACTTTG AGCACTCCCA GTGCCCCAGG CCCGCTGGTG 4860

TTCACTGCCC TGAGCCCAGA CTCGCTGCAG CTGAGCTGGG AGCGGCCACG GAGGCCCAAT 4920

GGGGATATCG TCGGCTACCT GGTGACCTGT GAGATGGCCC AAGGAGGAGG GCCAGCCACC 4980

GCATTCCGGG TGGATGGAGA CAGCCCCGAG AGCCGGCTGA CCGTGCCGGG CCTCAGCGAG 5040

AACGTGCCCT ACAAGTTCAA GGTGCAGGCC AGGACCACTG AGGGCTTCGG GCCAGAGCGC 5100

GAGGGCATCA TCACCATAGA GTCCCAGGAT GGAGGACCCT TCCCGCAGCT GGGCAGCCGT 5160

GCCGGGCTCT TCCAGCACCC GCTGCAAAGC GAGTACAGCA GCATCACCAC CACCCACACC 5220

AGCGCCACCG AGCCCTTCCT AGTGGATGGG CCGACCCTGG GGGCCCAGCA CCTGGAGGCA 5280

GGCGGCTCCC TCACCCGGCA TGTGACCCAG GAGTTTGTGA GCCGGACACT GACCACCAGC 5340

GGAACCCTTA GCACCCACAT GGACCAACAG TTCTTCCAAA CTTGACCGCA CCCTGCCCCA 5400

CCCCCGCCAT GTCCCACTAG GCGTCCTCCC GACTCCTCTC CCGGAGCCTC CTCAGCTACT 5460

CCATCCTTGC ACCCCTGGGG GCCCAGCCCA CCCGCATGCA CAGAGCAGGG GCTAGGTGTC 5520

TCCTGGGAGG CATGAAGGGG GCAAGGTCCG TCCTCTGTGG GCCCAAACCT ATTTGTAACC 5580

AAAGAGCTGG GAGCAGCACA AGGACCCAGC CTTTGTTCTG CACTTAATAA ATGGTTTTGC 5640 ACTG

Seq ID NO: 130 Protein sequence: Protein Accession #: NP 000204

11 21 31 41 51

I I I I

MAGPRPSPWA RLLLAALISV SLSGTLANRC K IKAPVKSCTE CVRVDKDCAY C ITDEMFRDRR 60 CNTQAELLAA GCQRESI M ESSFQITEET QIDTTLRRSQ MSPQGLRVRL RPGEERHFEL 120 EVFEPLESPV DLYILMDFSN SMSDDLDNLK KMGQNLARVL SQLTSDYTIG FGKFVDKVSV 180 PQTDMRPEKL KEPWPNSDPP FSFKNVISLT EDVDEFRNKL QGERISGNLD APEGGFDAIL 240 QTAVCTRDIG WRPDSTHLLV FSTESAFHYE ADGANVLAGI MSRNDERCHL DTTGTYTQYR 300 TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHTYF PVSSLGVLQE DSSNIVELLE 360 EAFNRIRSNL DIRALDSPRG LRTEVTSKMF QKTRTGSFHI RRGEVGIYQV QLRALEHVDG 420 THVCQLPEDQ KGNIHLKPSF SDGLKMDAGI ICDVCTCELQ KEVRSARCSP NGDFVCGQCV 480 CSEGWSGQTC NCSTGSLSDI QPCLREGEDK PCSGRGECQC GHCVCYGEGR YEGQFCEYDN 540 FQCPRTSGFL CNDRGRCSMG QCVCEPGWTG PSCDCPLSNA TCIDSNGGIC NGRGHCECGR 600 CHCHQQSLYT DTICEINYSA IHPGLCEDLR SCVQCQAWGT GEKKGRTCEE CNFKVKMVDE 660 LKRAEEWVR CSFRDEDDDC TYSYTMEGDG APGPNSTVLV HKKKDCPPGS FWWLIPLLLL 720 LLPLLALLLL LCWKYCACCK ACLALLPCCN RGHMVGFKED HYMLRENLMA SDHLDTPMLR 780 SGNLKGRDW RWKVTNNMQR PGFATHAASI NPTELVPYGL SLRLARLCTE NLLKPDTREC 840 AQLRQEVEEN LNEVYRQISG VHKLQQTKFR QQPNAGKKQD HTIVDTVLMA PRSAKPALLK 900 LTEKQVEQRA FHDLKVAPGY YTLTADQDAR GMVEFQEGVE LVDVRVPLFI RPEDDDEKQL 960 LVEAIDVPAG TATLGRRLVN ITIIKEQARD WSFEQPEFS VSRGDQVARI PVIRRVLDGG 1020 KSQVSYRTQD GTAQGNRDYI PVEGELLFQP GEAWKELQVK LLELQEVDSL LRGRQVRRFH 1080 VQLSNPKFGA HLGQPHSTTI IIRDPDELDR SFTSQMLSSQ PPPHGDLGAP QNPNAKAAGS 1140 RKIHFNWLPP SGKPMGYRVK YWIQGDSESE AHLLDSKVPS VELTNLYPYC DYEMKVCAYG 1200 AQGEGPYSSL VSCRTHQEVP SEPGRLAFNV VSSTVTQLSW AEPAETNGEI TAYEVCYGLV 1260 NDDNRPIGPM KKVLVDNPKN RML IENLRE SQPYRYTVKA RNGAGWGPER EAIINLATQP 1320 KRPMSIPIIP DIPIVDAQSG EDYDSFLMYS DDVLRSPSGS QRPSVSDDTE HLVNGRMDFA 1380 FPGSTNSLHR MTTTSAAAYG THLSPHVPHR VLSTSSTLTR DYNSLTRSEH SHSTTLPRDY 1440 STLTSVSSHD SRLTAGVPDT PTRLVFSALG PTSLRVSWQE PRCERPLQGY SVEYQLLNGG 1500 ELHRLNIPNP AQTSWVEDL LPNHSYVFRV RAQSQEGWGR EREGVITIES QVHPQSPLCP 1560 LPGSAFTLST PSAPGPLVFT ALSPDSLQLS WERPRRPNGD IVGYLVTCEM AQGGGPATAF 1620 RVDGDSPESR LTVPGLSENV PYKFKVQART TEGFGPEREG IITIESQDGG PFPQLGSRAG 1680 LFQHPLQSEY SSITTTHTSA TEPFLVDGPT LGAQHLEAGG SLTRHVTQEF VSRTLTTSGT 1740 LSTHMDQQFF QT

Seq ID NO: 131 DNA sequence Nucleic Acid Accession #: BC004372 Coding sequence: 132..2231

11 21 31 41 51

CCTCGTGCCG CGGACCCCAG CCTCTGCCAG GTTCGGTCCG CCATCCTCGT CCCGTCCTCC 60 GCCGGCCCCT GCCCCGCGCC CAGGGATCCT CCAGCTCCTT TCGCCCGCGC CCTCCGTTCG 120 CTCCGGACAC CATGGACAAG TTTTGGTGGC ACGCAGCCTG GGGACTCTGC CTCGTGCCGC 180 TGAGCCTGGC GCAGATCGAT TTGAATATAA CCTGCCGCTT TGCAGGTGTA TTCCACGTGG 240 AGAAAAATGG TCGCTACAGC ATCTCTCGGA CGGAGGCCGC TGACCTCTGC AAGGCTTTCA 300 ATAGCACCTT GCCCACAATG GCCCAGATGG AGAAAGCTCT GAGCATCGGA TTTGAGACCT 360 GCAGGTATGG GTTCATAGAA GGGCATGTGG TGATTCCCCG GATCCACCCC AACTCCATCT 420 GTGCAGCAAA CAACACAGGG GTGTACATCC TCACATCCAA CACCTCCCAG TATGACACAT 480 ATTGCTTCAA TGCTTCAGCT CCACCTGAAG AAGATTGTAC ATCAGTCACA GACCTGCCCA 540 ATGCCTTTGA TGGACCAATT ACCATAACTA TTGTTAACCG TGATGGCACC CGCTATGTCC 600 AGAAAGGAGA ATACAGAACG AATCCTGAAG ACATCTACCC CAGCAACCCT ACTGATGATG 660 ACGTGAGCAG CGGCTCCTCC AGTGAAAGGA GCAGCACTTC AGGAGGTTAC ATCTTTTACA 720 CCTTTTCTAC TGTACACCCC ATCCCAGACG AAGACAGTCC CTGGATCACC GACAGCACAG 780 ACAGAATCCC TGCTACCAGT ACGTCTTCAA ATACCATCTC AGCAGGCTGG GAGCCAAATG 840 AAGAAAATGA AGATGAAAGA GACAGACACC TCAGTTTTTC TGGATCAGGC ATTGATGATG 900 ATGAAGATTT TATCTCCAGC ACCATTTCAA CCACACCACG GGCTTTTGAC CACACAAAAC 960 AGAACCAGGA CTGGACCCAG TGGAACCCAA GCCATTCAAA TCCGGAAGTG CTACTTCAGA 1020 CAACCACAAG GATGACTGAT GTAGACAGAA ATGGCACCAC TGCTTATGAA GGAAACTGGA 1080 ACCCAGAAGC ACACCCTCCC CTCATTCACC ATGAGCATCA TGAGGAAGAA GAGACCCCAG 1140 ATTCTACAAG CACAATCCAG GCAACTCCTA GTAGTACAAC GGAAGAAACA GCTACCCAGA 1200 AGGAACAGTG GTTTGGCAAC AGATGGCATG AGGGATATCG CCAAACACCC AGAGAAGACT 1260 CCCATTCGAC AACAGGGACA GCTGCAGCCT CAGCTCATAC CAGCCATCCA ATGCAAGGAA 1320

GGACAACACC AAGCCCAGAG GACAGTTCCT GGACTGATTT CTTCAACCCA ATCTCACACC 1380

CCATGGGACG AGGTCATCAA GCAGGAAGAA GGATGGATAT GGACTCCAGT CATAGTACAA 1440

CGCTTCAGCC TACTGCAAAT CCAAACACAG GTTTGGTGGA AGATTTGGAC AGGACAGGAC 1500

CTCTTTCAAT GACAACGCAG CAGAGTAATT CTCAGAGCTT CTCTACATCA CATGAAGGCT 1560

TGGAAGAAGA TAAAGACCAT CCAACAACTT CTACTCTGAC ATCAAGCAAT AGGAATGATG 1620

TCACAGGTGG AAGAAGAGAC CCAAATCATT CTGAAGGCTC AACTACTTTA CTGGAAGGTT 1680

ATACCTCTCA TTACCCACAC ACGAAGGAAA GCAGGACCTT CATCCCAGTG ACCTCAGCTA 1740

AGACTGGGTC CTTTGGAGTT ACTGCAGTTA CTGTTGGAGA TTCCAACTCT AATGTCAATC 1800

GTTCCTTATC AGGAGACCAA GACACATTCC ACCCCAGTGG GGGGTCCCAT ACCACTCATG 1860

GATCTGAATC AGATGGACAC TCACATGGGA GTCAAGAAGG TGGAGCAAAC ACAACCTCTG 1920

GTCCTATAAG GACACCCCAA ATTCCAGAAT GGCTGATCAT CTTGGCATCC CTCTTGGCCT 1980

TGGCTTTGAT TCTTGCAGTT TGCATTGCAG TCAACAGTCG AAGAAGGTGT GGGCAGAAGA 2040

AAAAGCTAGT GATCAACAGT GGCAATGGAG CTGTGGAGGA CAGAAAGCCA AGTGGACTCA 2100

ACGGAGAGGC CAGCAAGTCT CAGGAAATGG TGCATTTGGT GAACAAGGAG TCGTCAGAAA 2160

CTCCAGACCA GTTTATGACA GCTGATGAGA CAAGGAACCT GCAGAATGTG GACATGAAGA 2220

TTGGGGTGTA ACACCTACAC CATTATCTTG GAAAGAAACA ACCGTTGGAA ACATAACCAT 2280

TACAGGGAGC TGGGACACTT AACAGATGCA ATGTGCTACT GATTGTTTCA TTGCGAATCT 2340 TTTTTAGCAT AAAATTTTCT ACTCTTAAAA AAAAAAAAAA AAAAAAA

Seq ID NO: 132 Protein sequence: Protein Accession #: AAH04372

11 21 31 41 51

MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA DLCKAFNSTL 60 PTMAQMEKAL SIGFETCRYG FIEGHWIPR IHPNSICAAN NTGVYILTSN TSQYDTYCFN 120 ASAPPEEDCT SVTDLPNAFD GPITITIVNR DGTRYVQKGE YRTNPEDI P SNPTDDDVSS 180 GSSSERSSTS GGYIFYTFST VHPIPDEDSP WITDSTDRIP ATSTSSNTIS AGWEPNEENE 240 DERDRHLSFS GSGIDDDEDF ISSTISTTPR AFDHTKQNQD WTQWNPSHSN PEVLLQTTTR 300 MTDVDRNGTT AYEGNWNPEA HPPLIHHEHH EEEETPHSTS TIQATPSSTT EETATQKEQW 360 FGNRWHEGYR QTPREDSHST TGTAAASAHT SHPMQGRTTP SPEDSSWTDF FNPISHPMGR 420 GHQAGRRMDM DSSHSTTLQP TANPNTGLVE DLDRTGPLSM TTQQSNSQSF STSHEGLEED 480 KDHPTTSTLT SSNRNDVTGG RRDPNHSEGS TTLLEGYTSH YPHTKESRTF IPVTSAKTGS 540 FGVTAVTVGD SNSNVNRSLS GDQDTFHPSG GSHTTHGSES DGHSHGSQEG GANTTSGPIR 600 TPQIPEWLII LASLLALALI LAVCIAVNSR RRCGQKKKLV INSGNGAVED RKPSGLNGEA 660 SKSQEMVHLV NKESSETPDQ FMTADETRNL QNVDMKIGV

Seq ID NO: 133 DNA sequence Nucleic Acid Accession #: NM_002882 Coding sequence: 150-755

11 21 31 41 51

CGAGGTTCGG GTCGTGGGGC GGAGGGAAGA GCGGGCGGGC GGGAGGCGCC GGCGCCAGAC 60 GCGGAGGGAA GGAGCTACGA GTAGCCGCCG AGAGGCCGCG GAGCCAGCGA CGACCGACCC 120 AGCCGAGCCG CCGCCGCCGC CGCGCCCCCA TGGCGGCCGC CAAGGACACT CATGAGGACC 180 ATGATACTTC CACTGAGAAT ACAGACGAGT CCAACCATGA CCCTCAGTTT GAGCCAATAG 240 TTTCTCTTCC TGAGCAAGAA ATTAAAACAC TGGAAGAAGA TGAAGAGGAA CTTTTTAAAA 300 TGCGGGCAAA ACTGTTCCGA TTTGCCTCTG AGAACGATCT CCCAGAATGG AAGGAGCGAG 360 GCACTGGTGA CGTCAAGCTC CTGAAGCACA AGGAGAAAGG GGCCATCCGC CTCCTCATGC 420 GGAGGGACAA GACCCTGAAG ATCTGTGCCA ACCACTACAT CACGCCGATG ATGGAGCTGA 480 AGCCCAACGC AGGTAGCGAC CGTGCCTGGG TCTGGAACAC CCACGCTGAC TTCGCCGACG 540 AGTGCCCCAA GCCAGAGCTG CTGGCCATCC GCTTCCTGAA TGCTGAGAAT GCACAGAAAT 600 TCAAAACAAA GTTTGAAGAA TGCAGGAAAG AGATCGAAGA GAGAGAAAAG AAAGCAGGAT 660 CAGGCAAAAA TGATCATGCC GAAAAAGTGG CGGAAAAGCT AGAAGCTCTC TCGGTGAAGG 720 AGGAGACCAA GGAGGATGCT GAGGAGAAGC AATAAATCGT CTTATTTTAT TTTCTTTTCC 780 TCTCTTTCCT TTCCTTTTTT TAAAAAATTT TACCCTGCCC CTCTTTTTCG GTTTGTTTTT 840 ATTCTTTCAT TTTTACAAGG GACGTTATAT AAAGAACTGA ACTC

Seq ID NO : 134 Protein sequence : Protein Accession # : NP 002873

1 11 21 31 41 51

I I I I I I

MAAAKDTHED HDTSTENTDE SNHDPQFEPI VSLPEQEIKT LEEDEEELFK MRAKLFRFAS 60 ENDLPEWKER GTGDVKLLKH KEKGAIRLLM RRDKTLKICA NHYITPMMEL KPNAGSDRAW 120

VWNTHADFAD ECPKPELLAI RFLNAENAQK FKTKFEECRK EIEEREKKAG SGKNDHAEKV 180

AEKLEALSVK EETKEDAEEK Q

Seq ID NO: 135 DNA sequence Nucleic Acid Accession #: NM_000077.2 Coding sequence: 277-742

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I I I I I

CCCAACCTGG GGCGACTTCA GGTGTGCCAC ATTCGCTAAG TGCTCGGAGT TAATAGCACC 60 TCCTCCGAGC ACTCGCTCAC GGCGTCCCCT TGCCTGGAAA GATACCGCGG TCCCTCCAGA 120 GGATTTGAGG GACAGGGTCG GAGGGGGCTC TTCCGCCAGC ACCGGAGGAA GAAAGAGGAG 180 GGGCTGGCTG GTCACCAGAG GGTGGGGCGG ACCGCGTGCG CTCGGCGGCT GCGGAGAGGG 240 GGAGAGCAGG CAGCGGGCGG CGGGGAGCAG CATGGAGCCG GCGGCGGGGA GCAGCATGGA 300 GCCTTCGGCT GACTGGCTGG CCACGGCCGC GGCCCGGGGT CGGGTAGAGG AGGTGCGGGC 360 GCTGCTGGAG GCGGGGGCGC TGCCCAACGC ACCGAATAGT TACGGTCGGA GGCCGATCCA 420 GGTCATGATG ATGGGCAGCG CCCGAGTGGC GGAGCTGCTG CTGCTCCACG GCGCGGAGCC 480 CAACTGCGCC GACCCCGCCA CTCTCACCCG ACCCGTGCAC GACGCTGCCC GGGAGGGCTT 540

CCTGGACACG CTGGTGGTGC TGCACCGGGC CGGGGCGCGG CTGGACGTGC GCGATGCCTG 600

GGGCCGTCTG CCCGTGGACC TGGCTGAGGA GCTGGGCCAT CGCGATGTCG CACGGTACCT 660

GCGCGCGGCT GCGGGGGGCA CCAGAGGCAG TAACCATGCC CGCATAGATG CCGCGGAAGG 720

TCCCTCAGAC ATCCCCGATT GAAAGAACCA GAGAGGCTCT GAGAAACCTC GGGAAACTTA 780

GATCATCAGT CACCGAAGGT CCTACAGGGC CACAACTGCC CCCGCCACAA CCCACCCCGC 840

TTTCGTAGTT TTCATTTAGA AAATAGAGCT TTTAAAAATG TCCTGCCTTT TAACGTAGAT 900

ATATGCCTTC CCCCACTACC GTAAATGTCC ATTTATATCA TTTTTTATAT ATTCTTATAA 960

AAATGTAAAA AAGAAAAACA CCGCTTCTGC CTTTTCACTG TGTTGGAGTT TTCTGGAGTG 1020

AGCACTCACG CCCTAAGCGC ACATTCATGT GGGCATTTCT TGCGAGCCTC GCAGCCTCCG 1080

GAAGCTGTCG ACTTCATGAC AAGCATTTTG TGAACTAGGG AAGCTCAGGG GGGTTACTGG 1140

CTTCTCTTGA GTCACACTGC TAGCAAATGG CAGAACCAAA GCTCAAATAA AAATAAAATA 1200 ATTTTCATTC ATTCACTC

Seq ID NO: 136 Protein sequence: Protein Accession #: NP 000068.1

1 11 21 31 41 51

1 I I I I I

MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA 60 ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLWLHRA GARLDVRDAW GRLPVDLAEE 120 LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD

Seq ID NO: 137 DNA sequence

Nucleic Acid Accession ft: NM_058196.

Coding sequence: 104-421

1 11 21 31 41 51

1 1 I 1 1 1 1 1 | 1

TGTGTGGGGG TCTGCTTGGC GGTGAGGGGG CTCTACACAA GCTTCCTTTC CGTCATGCCG 60

GCCCCCACCC TGGCTCTGAC CATTCTGTTC TCTCTGGCAG GTCATGATGA TGGGCAGCGC 120

CCGAGTGGCG GAGCTGCTGC TGCTCCACGG CGCGGAGCCC AACTGCGCCG ACCCCGCCAC 180

TCTCACCCGA CCCGTGCACG ACGCTGCCCG GGAGGGCTTC CTGGACACGC TGGTGGTGCT 240

GCACCGGGCC GGGGCGCGGC TGGACGTGCG CGATGCCTGG GGCCGTCTGC CCGTGGACCT 300

GGCTGAGGAG CTGGGCCATC GCGATGTCGC ACGGTACCTG CGCGCGGCTG CGGGGGGCAC 360

CAGAGGCAGT AACCATGCCC GCATAGATGC CGCGGAAGGT CCCTCAGACA TCCCCGATTG 420

AAAGAACCAG AGAGGCTCTG AGAAACCTCG GGAAACTTAG ATCATCAGTC ACCGAAGGTC 480

CTACAGGGCC ACAACTGCCC CCGCCACAAC CCACCCCGCT TTCGTAGTTT TCATTTAGAA 540

AATAGAGCTT TTAAAAATGT CCTGCCTTTT AACGTAGATA TAAGCCTTCC CCCACTACCG 600

TAAATGTCCA TTTATATCAT TTTTTATATA TTCTTATAAA AATGTAAAAA AGAAAAACAC 660

CGCTTCTGCC TTTTCACTGT GTTGGAGTTT TCTGGAGTGA GCACTCACGC CCTAAGCGCA 720

CATTCATGTG GGCATTTCTT GCGAGCCTCG CAGCCTCCGG AAGCTGTCGA CTTCATGACA 780

AGCATTTTGT GAACTAGGGA AGCTCAGGGG GGTTACTGGC TTCTCTTGAG TCACACTGCT 840

AGCAAATGGC AGAACCAAAG CTCAAATAAA AATAAAATAA TTTTCATTCA TTCACTC

Seq ID NO: 138 Protein sequence: Protein Accession #: NP 478103.1

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I I I I I I

MMMGSARVAE LLLLHGAEPN CADPATLTRP VHDAAREGFL DTLWLHRAG ARLDVRDAWG 60 RLPVDLAEEL GHRDVARYLR AAAGGTRGSN HARIDAAEGP SDIPD

Seq ID NO: 139 DNA sequence

Nucleic Acid Accession #: NM_058197.

Coding sequence: 272-684

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I 1 I

CCCAACCTGG GGCGACTTCA G 1GTGTGCCAC ATTCGCTAAG T 1GCTCGGAGT TAATAGCACC 60 TCCTCCGAGC ACTCGCTCAC GGCGTCCCCT TGCCTGGAAA GATACCGCGG TCCCTCCAGA 120 GGATTTGAGG GACAGGGTCG GAGGGGGCTC TTCCGCCAGC ACCGGAGGAA GAAAGAGGAG 180 GGGCTGGCTG GTCACCAGAG GGTGGGGCGG ACCGCGTGCG CTCGGCGGCT GCGGAGAGGG 240 GGAGAGCAGG CAGCGGGCGG CGGGGAGCAG CATGGAGCCG GCGGCGGGGA GCAGCATGGA 300 GCCGGCGGCG GGGAGCAGCA TGGAGCCTTC GGCTGACTGG CTGGCCACGG CCGCGGCCCG 360 GGGTCGGGTA GAGGAGGTGC GGGCGCTGCT GGAGGCGGGG GCGCTGCCCA ACGCACCGAA 420 TAGTTACGGT CGGAGGCCGA TCCAGGTGGG TAGAAGGTCT GCAGCGGGAG CAGGGGATGG 480 CGGGCGACTC TGGAGGACGA AGTTTGCAGG GGAATTGGAA TCAGGTAGCG CTTCGATTCT 540 CCGGAAAAAG GGGAGGCTTC CTGGGGAGTT TTCAGAAGGG GTTTGTAATC ACAGACCTCC 600 TCCTGGCGAC GCCCTGGGGG CTTGGGAAAC CAAGGAAGAG GAATGAGGAG CCACGCGCGT 660 ACAGATCTCT CGAATGCTGA GAAGATCTGA AGGGGGGAAC ATATTTGTAT TAGATGGAAG 720 TCATGATGAT GGGCAGCGCC CGAGTGGCGG AGCTGCTGCT GCTCCACGGC GCGGAGCCCA 780 ACTGCGCCGA CCCCGCCACT CTCACCCGAC CCGTGCACGA CGCTGCCCGG GAGGGCTTCC 840 TGGACACGCT GGTGGTGCTG CACCGGGCCG GGGCGCGGCT GGACGTGCGC GATGCCTGGG 900 GCCGTCTGCC CGTGGACCTG GCTGAGGAGC TGGGCCATCG CGATGTCGCA CGGTACCTGC 960 GCGCGGCTGC GGGGGGCACC AGAGGCAGTA ACCATGCCCG CATAGATGCC GCGGAAGGTC 1020 CCTCAGACAT CCCCGATTGA AAGAACCAGA GAGGCTCTGA GAAACCTCGG GAACTTAGAT 1080 CATCAGTCAC CGAAGGTCCT ACAGGGCCAC AACTGCCCCC GCCACAACCC ACCCCGCTTT 1140 CGTAGTTTTC ATTTAGAAAA TAGAGCTTTT AAAAATGTCC TGCCTTTTAA CGTAGATATA 1200 TGCCTTCCCC CACTACCGTA AATGTCCATT TATATCATTT TTTATATATT CTTATAAAAA 1260 TGTAAAAAAG AAAAACACCG CTTCTGCCTT TTCACTGTGT TGGAGTTTTC TGGAGTGAGC 1320 ACTCACGCCC TAAGCGCACA TTCATGTGGG CATTTCTTGC GAGCCTCGCA GCCTCCGGAA 1380 GCTGTCGACT TCATGACAAG CATTTTGTGA ACTAGGGAAG CTCAGGGGGG TTACTGGCTT 1440 CTCTTGAGTC ACACTGCTAG CAAATGGCAG AACCAAAGCT CAAATAAAAA TAAAATAATT 1500 TTCATTCATT CACTC

Seq ID NO: 140 Protein sequence: Protein Accession ft: NP 478104.1

1 11 21 31 41 51

I I I I I I

MEPAAGSSME PAAGSSMEPS ADWLATAAAR GRVEEVRALL EAGALPNAPN SYGRRPIQVG 60 RRSAAGAGDG GRLWRTKFAG ELESGSASIL RKKGRLPGEF SEGVCNHRPP PGDALGAWET 120 KEEE

Seq ID NO: 141 DNA sequence

Nucleic Acid Accession #: NM_058195.1

Coding sequence: 163-684

11 21 31 41 51

I I I I I

CCTCCCTACG GGCGCCTCCG GCAGCCCTTC CCGCGTGCGC AGGGCTCAGA GCCGTTCCGA 60 GATCTTGGAG GTCCGGGTGG GAGTGGGGGT GGGGTGGGGG TGGGGGTGAA GGTGGGGGGC 120 GGGCGCGCTC AGGGAAGGCG GGTGCGCGCC TGCGGGGCGG AGATGGGCAG GGGGCGGTGC 180 GTGGGTCCCA GTCTGCAGTT AAGGGGGCAG GAGTGGCGCT GCTCACCTCT GGTGCCAAAG 240 GGCGGCGCAG CGGCTGCCGA GCTCGGCCCT GGAGGCGGCG AGAACATGGT GCGCAGGTTC 300 TTGGTGACCC TCCGGATTCG GCGCGCGTGC GGCCCGCCGC GAGTGAGGGT TTTCGTGGTT 360 CACATCCCGC GGCTCACGGG GGAGTGGGCA GCGCCAGGGG CGCCCGCCGC TGTGGCCCTC 420 GTGCTGATGC TACTGAGGAG CCAGCGTCTA GGGCAGCAGC CGCTTCCTAG AAGACCAGGT 480 CATGATGATG GGCAGCGCCC GAGTGGCGGA GCTGCTGCTG CTCCACGGCG CGGAGCCCAA 540 CTGCGCCGAC CCCGCCACTC TCACCCGACC CGTGCACGAC GCTGCCCGGG AGGGCTTCCT 600 GGACACGCTG GTGGTGCTGC ACCGGGCCGG GGCGCGGCTG GACGTGCGCG ATGCCTGGGG 660 CCGTCTGCCC GTGGACCTGG CTGAGGAGCT GGGCCATCGC GATGTCGCAC GGTACCTGCG 720 CGCGGCTGCG GGGGGCACCA GAGGCAGTAA CCATGCCCGC ATAGATGCCG CGGAAGGTCC 780 CTCAGACATC CCCGATTGAA AGAACCAGAG AGGCTCTGAG AAACCTCGGG AAACTTAGAT 840 CATCAGTCAC CGAAGGTCCT ACAGGGCCAC AACTGCCCCC GCCACAACCC ACCCCGCTTT 900 CGTAGTTTTC ATTTAGAAAA TAGAGCTTTT AAAAATGTCC TGCCTTTTAA CGTAGATATA 960 TGCCTTCCCC CACTACCGTA AATGTCCATT TATATCATTT TTTATATATT CTTATAAAAA 1020 TGTAAAAAAG AAAAACACCG CTTCTGCCTT TTCACTGTGT TGGAGTTTTC TGGAGTGAGC 1080 ACTCACGCCC TAAGCGCACA TTCATGTGGG CATTTCTTGC GAGCCTCGCA GCCTCCGGAA 1140 GCTGTCGACT TCATGACAAG CATTTTGTGA ACTAGGGAAG CTCAGGGGGG TTACTGGCTT 1200 CTCTTGAGTC ACACTGCTAG CAAATGGCAG AACCAAAGCT CAAATAAAAA TAAAATAATT 1260 TTCATTCATT CACTC

Seq ID NO: 142 Protein sequence: Protein Accession U NP 478102.1

11 21 31 41 51

I

MGRGRCVGPS LQLRGQEWRC SPLVPKGGAA AAELGPGGGE NMVRRFLVTL RIRRACGPPR 60 VRVFWHIPR LTGEWAAPGA PAAVALVLML LRSQRLGQQP LPRRPGHDDG QRPSGGAAAA 120 PRRGAQLRRP RHSHPTRARR CPGGLPGHAG GAAPGRGAAG RARCLGPSAR GPG

Seq ID NO: 143 DNA sequence Nucleic Acid Accession #: NM_018131 Coding sequence: 412..1107

11 21 31 41 51

GAAATTGCAC ACTTAAAGAC ATCAGTGGAT GAAATCACAA GTGGGAAAGG AAAGCTGACT 60 GATAAAGAGA GACAGAGACT TTTGGAGAAA ATTCGAGTCC TTGAGGCTGA GAAGGAGAAG 120 AATGCTTATC AACTCACAGA GAAGGACAAA GAAATACAGC GACTGAGAGA CCAACTGAAG 180 GCCAGATATA GTACTACCGC ATTGCTTGAA CAGCTGGAAG AGACAACGAG AGAAGGAGAA 240 AGGAGGGAGC AGGTGTTGAA AGCCTTATCT GAAGAGAAAG ACGTATTGAA ACAACAGTTG 300 TCTGCTGCAA CCTCACGAAT TGCTGAACTT GAAAGCAAAA CCAATACACT CCGTTTATCA 360 CAGACTGTGG CTCCAAACTG CTTCAACTCA TCAATAAATA ATATTCATGA AATGGAAATA 420 CAGCTGAAAG ATGCTCTGGA GAAAAATCAG CAGTGGCTCG TGTATGATCA GCAGCGGGAA 480 GTCTATGTAA AAGGACTTTT AGCAAAGATC TTTGAGTTGG AAAAGAAAAC GGAAACAGCT 540 GCTCATTCAC TCCCACAGCA GACAAAAAAG CCTGAATCAG AAGGTTATCT TCAAGAAGAG 600 AAGCAGAAAT GTTACAACGA TCTCTTGGCA AGTGCAAAAA AAGATCTTGA GGTTGAACGA 660 CAAACCATAA CTCAGCTGAG TTTTGAACTG AGTGAATTTC GAAGAAAATA TGAAGAAACC 720 CAAAAAGAAG TTCACAATTT AAATCAGCTG TTGTATTCAC AAAGAAGGGC AGATGTGCAA 780 CATCTGGAAG ATGATAGGCA TAAAACAGAG AAGATACAAA AACTCAGGGA AGAGAATGAT 840 ATTGCTAGGG GAAAACTTGA AGAAGAGAAG AAGAGATCCG AAGAGCTCTT ATCTCAGGTC 900 CAGTCTCTTT ACACATCTCT GCTAAAGCAG CAAGAAGAAC AAACAAGGGT AGCTCTGTTG 960 GAACAACAGA TGCAGGCATG TACTTTAGAC TTTGAAAATG AAAAACTCGA CCGTCAACAT 1020 GTGCAGCATC AATTGCATGT AATTCTTAAG GAGCTCCGAA AAGCAAGAAA AAATAACACA 1080 GTTGGAATCC TTGAAACAGC TTCATGAGTT TGCCATCACA GAGCCATTAG TCACTTTCCA 1140 AGGAGAGACT GAAAACAGAG AAAAAGTTGC CGCCTCACCA AAAAGTCCCA CTGCTGCACT 1200 CAATGGAAGC CTGGTGGAAT GTCCCAAGTG CAATATACAG TATCCAGCCA CTGAGCATCG 1260 CGATCTGCTT GTCCATGTGG AATACTGTTC AAAGTAGCAA AATAAGTATT TGTTTTGATA 1320 TTAAAAGATT CAATACTGTA TTTTCTGTTA GCTTGTGGGC ATTTTGAATT ATATATTTCA 1380 CATTTTGCAT AAAACTGCCT ATCTACCTTT GACACTCCAG CATGCTAGTG AATCATGTAT 1440 CTTTTAGGCT GCTGTGCATT TCTCTTGGCA GTGATACCTC CCTGACATGG TTCATCATCA 1500 GGCTGCAATG ACAGAATGTG GTGAGCAGCG TCTACTGAGA TACTAACATT TTGCACTGTC 1560 AAAATACTTG GTGAGGAAAA GATAGCTCAG GTTATTGCTA ATGGGTTAAT GCACCAGCAA 1620 GCAAAATATT TTATGTTTCG GGGGTTTTGA AAAATCAAAG ATAATTAACC AAGGATCTTA 1680 ACTGTGTTCG CATTTTTTAT CCAAGCACTT AGAAAACCTA CAATCCTAAT TTTGATGTCC 1740 ATTGTTAAGA GGTGGTGATA GATACTATTT TTTTTTCATA TTGTATAGCG GTTATTAGAA 1800 AAGTTGGGGA TTTTCTTGAT CTTTATTGCT GCTTACCATT GAAACTTAAC CCAGCTGTGT 1860

TCCCCAACTC TGTTCTGCGC ACGAAACAGT ATCTGTTTGA GGCATAATCT TAAGTGGCCA 1920

CACACAATGT TTTCTCTTAT GTTATCTGGC AGTAACTGTA ACTTGAATTA CATTAGCACA 1980

TTCTGCTTAG CTAAAATTGT TAAAATAAAC TTTAATAAAC CCATGTAGCC CTCTCATTTG 2040

ATTGACAGTA TTTTAGTTAT TTTTGGCATT CTTAAAGCTG GGCAATGTAA TGATCAGATC 2100

TTTGTTTGTC TGAACAGGTA TTTTTATACA TGCTTTTTGT AAACCAAAAA CTTTTAAATT 2160

TCTTCAGGTT TTCTAACATG CTTACCACTG GGCTACTGTA AATGAGAAAA GAATAAAATT 2220 ATTTAATGTT TT

Seq ID NO: 144 Protein sequence: Protein Accession #: NP 060601 1 11 21 31 41 51

I I I I I 1

MEIQLKDALE KNQQWLVYDQ QREVYVKGLL AKIFELEKKT ETAAHSLPQQ TKKPESEGYL 60 QEEKQKCYND LLASAKKDLE VERQTITQLS FELSEFRRKY EETQKEVHNL NQLLYSQRRA 120 DVQHLEDDRH KTEKIQKLRE ENDIARGKLE EEKKRSEELL SQVQSLYTSL LKQQEEQTRV 180 ALLEQQMQAC TLDFENEKLD RQHVQHQLHV ILKELRKARK NNTVGILETA S

Seq ID NO: 145 DNA sequence Nucleic Acid Accession #: NM_001168 Coding sequence: 50..478

1 11 21 31 41 51

I I I I I I

CCGCCAGATT TGAATCGCGG GACCCGTTGG CAGAGGTGGC GGCGGCGGCA TGGGTGCCCC 60 GACGTTGCCC CCTGCCTGGC AGCCCTTTCT CAAGGACCAC CGCATCTCTA CATTCAAGAA 120

CTGGCCCTTC TTGGAGGGCT GCGCCTGCAC CCCGGAGCGG ATGGCCGAGG CTGGCTTCAT 180

CCACTGCCCC ACTGAGAACG AGCCAGACTT GGCCCAGTGT TTCTTCTGCT TCAAGGAGCT 240

GGAAGGCTGG GAGCCAGATG ACGACCCCAT AGAGGAACAT AAAAAGCATT CGTCCGGTTG 300

CGCTTTCCTT TCTGTCAAGA AGCAGTTTGA AGAATTAACC CTTGGTGAAT TTTTGAAACT 360 GGACAGAGAA AGAGCCAAGA ACAAAATTGC AAAGGAAACC AACAATAAGA AGAAAGAATT 420

TGAGGAAACT GCGAAGAAAG TGCGCCGTGC CATCGAGCAG CTGGCTGCCA TGGATTGAGG 480

CCTCTGGCCG GAGCTGCCTG GTCCCAGAGT GGCTGCACCA CTTCCAGGGT TTATTCCCTG 540

GTGCCACCAG CCTTCCTGTG GGCCCCTTAG CAATGTCTTA GGAAAGGAGA TCAACATTTT 600

CAAATTAGAT GTTTCAACTG TGCTCCTGTT TTGTCTTGAA AGTGGCACCA GAGGTGCTTC 660 TGCCTGTGCA GCGGGTGCTG CTGGTAACAG TGGCTGCTTC TCTCTCTCTC TCTCTTTTTT 720

GGGGGCTCAT TTTTGCTGTT TTGATTCCCG GGCTTACCAG GTGAGAAGTG AGGGAGGAAG 80

AAGGCAGTGT CCCTTTTGCT AGAGCTGACA GCTTTGTTCG CGTGGGCAGA GCCTTCCACA 840

GTGAATGTGT CTGGACCTCA TGTTGTTGAG GCTGTCACAG TCCTGAGTGT GGACTTGGCA 900

GGTGCCTGTT GAATCTGAGC_' TGCAGGTTCC TTATCTGTCA CACCTGTGCC TCCTCAGAGG 960 ACAGTTTTTT TGTTGTTGTG TTTTTTTGTT TTTTTTTTTT GGTAGATGCA TGACTTGTGT 1020

GTGATGAGAG AATGGAGACA GAGTCCCTGG CTCCTCTACT GTTTAACAAC ATGGCTTTCT 1080

TATTTTGTTT GAATTGTTAA TTCACAGAAT AGCACAAACT ACAATTAAAA CTAAGCACAA 1140

AGCCATTCTA AGTCATTGGG GAAACGGGGT GAACTTCAGG TGGATGAGGA GACAGAATAG 1200

AGTGATAGGA AGCGTCTGGC AGATACTCCT TTTGCCACTG CTGTGTGATT AGACAGGCCC 1260 AGTGAGCCGC GGGGCACATG CTGGCCGCTC CTCCCTCAGA AAAAGGCAGT GGCCTAAATC 1320

CTTTTTAAAT GACTTGGCTC GATGCTGTGG GGGACTGGCT GGGCTGCTGC AGGCCGTGTG 1380

TCTGTCAGCC CAACCTTCAC ATCTGTCACG TTCTCCACAC GGGGGAGAGA CGCAGTCCGC 1440

CCAGGTCCCC GCTTTCTTTG GAGGCAGCAG CTCCCGCAGG GCTGAAGTCT GGCGTAAGAT 1500

GATGGATTTG ATTCGCCCTC CTCCCTGTCA TAGAGCTGCA GGGTGGATTG TTACAGCTTC 1560 GCTGGAAACC TCTGGAGGTC ATCTCGGCTG TTCCTGAGAA ATAAAAAGCC TGTCATTTC

Seq ID NO: 146 Protein sequence: Protein Accession #: NP 001159

1 11 21 31 41 51

I I I I I I

MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 60

FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 120 KKEFEETAKK VRRAIEQLAA MD

Seq ID NO: 147 DNA sequence

Nucleic Acid Accession #: NM_014176.1

Coding sequence: 127-720

1 11 21 31 41 51 ^•

I I I I I I

GCGCGCAGCG CTGGTACCCC GTTGGTCCGC GCGTTGCTGC GTTGTGAGGG GTGTCAGCTC 60

AGTGCATCCC AGGCAGCTCT TAGTGTGGAG CAGTGAACTG TGTGTGGTTC CTTCTACTTG 120

GGGATCATGC AGAGAGCTTC ACGTCTGAAG AGAGAGCTGC ACATGTTAGC CACAGAGCCA 180

CCCCCAGGCA TCACATGTTG GCAAGATAAA GACCAAATGG ATGACCTGCG AGCTCAAATA 240

TTAGGTGGAG CCAACACACC TTATGAGAAA GGTGTTTTTA AGCTAGAAGT TATCATTCCT 300

GAGAGGTACC CATTTGAACC TCCTCAGATC CGATTTCTCA CTCCAATTTA TCATCCAAAC 360

ATTGATTCTG CTGGAAGGAT TTGTCTGGAT GTTCTCAAAT TGCCACCAAA AGGTGCTTGG 420

AGACCATCCC TCAACATCGC AACTGTGTTG ACCTCTATTC AGCTGCTCAT GTCAGAACCC 480

AACCCTGATG ACCCGCTCAT GGCTGACATA TCCTCAGAAT TTAAATATAA TAAGCCAGCC 540

TTCCTCAAGA ATGCCAGACA GTGGACAGAG AAGCATGCAA GACAGAAACA AAAGGCTGAT 600

GAGGAAGAGA TGCTTGATAA TCTACCAGAG GCTGGTGACT CCAGAGTACA CAACTCAACA 660

CAGAAAAGGA AGGCCAGTCA GCTAGTAGGC ATAGAAAAGA AATTTCATCC TGATGTTTAG 720

GGGACTTGTC CTGGTTCATC TTAGTTAATG TGTTCTTTGC CAAGGTGATC TAAGTTGCCT 780

ACCTTGAATT TTTTTTTAAA TATATTTGAT GACATAATTT TTGTGTAGTT TATTTATCTT 840

GTACATATGT ATTTTGAAAT CTTTTAAACC TGAAAAATAA ATAGTCATTT AATGTTGAAA 900 AAAAAAAAAA AAAAAAAAAA AAAAAAAA

Seq ID NO: 148 Protein sequence: Protein Accession #: NP 054895.1

11 21 31 41 51

I

MQRASRLKRE LHMLATEPPP GITCWQDKDQ MDDLRAQILG GANTPYEKGV FKLEVIIPER 60 YPFEPPQIRF LTPIYHPNID SAGRICLDVL KLPPKGAWRP SLNIATVLTS IQLLMSEPNP 120 DDPLMADISS EFKYNKPAFL KNARQWTEKH ARQKQKADEE EMLDNLPEAG DSRVHNSTQK 180 RKASQLVGIE KKFHPDV

Seq ID NO: 149 DNA sequence Nucleic Acid Accession #: NM_003812 Coding sequence: 224-2722

11 21 31 41 51

TCCTCTGCGT CCCGCCCCGG GAGTGGCTGC GAGGCTAGGC GAGCCGGGAA AGGGGGCGCC 60 GCCCAGCCCC GAGCCCCGCG CCCCGTGCCC CGAGCCCGGA GCCCCCTGCC CGCGGCGGCA 120 CCATGCGCGC CGAGCCGGCG TGACCGGCTC CGCCCGCGGC CGCCCCGCAG CTAGCCCGGC 180 GCTCTCGCCG GCCACACGGA GCGGCGCCCG GGAGCTATGA GCCATGAAGC CGCCCGGCAG 240 CAGCTCGCGG CAGCCGCCCC TGGCGGGCTG CAGCCTTGCC GGCGCTTCCT GCGGCCCCCA 300 ACGCGGCCCC GCCGGCTCGG TGCCTGCCAG CGCCCCGGCC CGCACGCCGC CCTGCCGCCT 360 GCTTCTCGTC CTTCTCCTGC TGCCTCCGCT CGCCGCCTCG TCCCGGCCCC GCGCCTGGGG 420 GGCTGCTGCG CCCAGCGCTC CGCATTGGAA TGAAACTGCA GAAAAAAATT TGGGAGTCCT 480 GGCAGATGAA GACAATACAT TGCAACAGAA TAGCAGCAGT AATATCAGTT ACAGCAATGC 540 AATGCAGAAA GAAATCACAC TGCCTTCAAG ACTCATATAT TACATCAACC AAGACTCGGA 600 AAGCCCTTAT CACGTTCTTG ACACAAAGGC AAGACACCAG CAAAAACATA ATAAGGCTGT 660 CCATCTGGCC CAGGCAAGCT TCCAGATTGA AGCCTTCGGC TCCAAATTCA TTCTTGACCT 720 CATACTGAAC AATGGTTTGT TGTCTTCTGA TTATGTGGAG ATTCACTACG AAAATGGGAA 780 ACCACAGTAC TCTAAGGGTG GAGAGCACTG TTACTACCAT GGAAGCATCA GAGGCGTCAA 840 AGACTCCAAG GTGGCTCTGT CAACCTGCAA TGGACTTCAT GGCATGTTTG AAGATGATAC 900 CTTCGTGTAT ATGATAGAGC CACTAGAGCT GGTTCATGAT GAGAAAAGCA CAGGTCGACC 960 ACATATAATC CAGAAAACCT TGGCAGGACA GTATTCTAAG CAAATGAAGA ATCTCACTAT 1020 GGAAAGAGGT GACCAGTGGC CCTTTCTCTC TGAATTACAG TGGTTGAAAA GAAGGAAGAG 1080 AGCAGTGAAT CCATCACGTG GTATATTTGA AGAAATGAAA TATTTGGAAC TTATGATTGT 1140 TAATGATCAC AAAACGTATA AGAAGCATCG CTCTTCTCAT GCACATACCA ACAACTTTGC 1200 AAAGTCCGTG GTCAACCTTG TGGATTCTAT TTACAAGGAG CAGCTCAACA CCAGGGTTGT 1260 CCTGGTGGCT GTAGAGACCT GGACTGAGAA GGATCAGATT GACATCACCA CCAACCCTGT 1320 GCAGATGCTC CATGAGTTCT CAAAATACCG GCAGCGCATT AAGCAGCATG CTGATGCTGT 1380 GCACCTCATC TCGCGGGTGA CATTTCACTA TAAGAGAAGC AGTCTGAGTT ACTTTGGAGG 1440 TGTCTGTTCT CGCACAAGAG GAGTTGGTGT GAATGAGTAT GGTCTTCCAA TGGCAGTGGC 1500 ACAAGTATTA TCGCAGAGCC TGGCTCAAAA CCTTGGAATC CAATGGGAAC CTTCTAGCAG 1560 AAAGCCAAAA TGTGACTGCA CAGAATCCTG GGGTGGCTGC ATCATGGAGG AAACAGGGGT 1620 GTCCCATTCT CGAAAATTTT CAAAGTGCAG CATTTTGGAG TATAGAGACT TTTTACAGAG 1680 AGGAGGTGGA GCCTGCCTTT TCAACAGGCC AACAAAGCTA TTTGAGCCCA CGGAATGTGG 1740 AAATGGATAC GTGGAAGCTG GGGAGGAGTG TGATTGTGGT TTTCATGTGG AATGCTATGG 1800 ATTATGCTGT AAGAAATGTT CCCTCTCCAA CGGGGCTCAC TGCAGCGACG GGCCCTGCTG 1860 TAACAATACC TCATGTCTTT TTCAGCCACG AGGGTATGAA TGCCGGGATG CTGTGAACGA 1920 GTGTGATATT ACTGAATATT GTACTGGAGA CTCTGGTCAG TGCCCACCAA ATCTTCATAA 1980 GCAAGACGGA TATGCATGCA ATCAAAATCA GGGCCGCTGC TACAATGGCG AGTGCAAGAC 2040 CAGAGACAAC CAGTGTCAGT ACATCTGGGG AACAAAGGCT GCAGGGTCTG ACAAGTTCTG 2100 CTATGAAAAG CTGAATACAG AAGGCACTGA GAAGGGAAAC TGCGGGAAGG ATGGAGACCG 2160 GTGGATTCAG TGCAGCAAAC ATGATGTGTT CTGTGGATTC TTACTCTGTA CCAATCTTAC 2220 TCGAGCTCCA CGTATTGGTC AACTTCAGGG TGAGATCATT CCAACTTCCT TCTACCATCA 2280 AGGCCGGGTG ATTGACTGCA GTGGTGCCCA TGTAGTTTTA GATGATGATA CGGATGTGGG 2340 CTATGTAGAA GATGGAACGC CATGTGGCCC GTCTATGATG TGTTTAGATC GGAAGTGCCT 2400 ACAAATTCAA GCCCTAAATA TGAGCAGCTG TCCACTCGAT TCCAAGGGTA AAGTCTGTTC 2460 GGGCCATGGG GTGTGTAGTA ATGAAGCCAC CTGCATTTGT GATTTCACCT GGGCAGGGAC 2520 AGATTGCAGT ATCCGGGATC CAGTTAGGAA CCTTCACCCC CCCAAGGATG AAGGACCCAA 2580 GGGTCCTAGT GCCACCAATC TCATAATAGG CTCCATCGCT GGTGCCATCC TGGTAGCAGC 2640 TATTGTCCTT GGGGGCACAG GCTGGGGATT TAAAAATGTC AAGAAGAGAA GGTTCGATCC 2700 TACTCAGCAA GGCCCCATCT GAATCAGCTG CGCTGGATGG ACACCGCCTT GCACTGTTGG 2760 ATTCTGGGTA TGACATACTC GCAGCAGTGT TACTGGAACT ATTAAGTTTG TAAACAAAAC 2820 CTTTGGGTGG TAATGACTAC GGAGCTAAAG TTGGGGTGAC AAGGATGGGG TAAAAGAAAA 2880 CTGTCTCTTT TGGAAATAAT GTCAAAGAAC ACCTTTCACC ACCTGTCAGT AAACGGGGGA 2940 GGGGGCAAAA GACCATGCTA TAAAAAGAAC TGTTCCAGAA TGTTTTTTTT TCCCTAATGG 3000 ACGAAGGAAC AACACACACA CAAAAATTAA ATGCAATAAA GGAATCATTA AAAA

Seq ID NO: 150 Protein sequence: Protein Accession #: NP 003803

60

120

180

240

KSTGRPHIIQ KTLAGQYSKQ MKNLTMERGD QWPFLSELQW LKRRKRAVNP SRGIFEEMKY 300

LELMIVNDHK TYKKHRSSHA HTNNFAKSW NLVDSIYKEQ LNTRWLVAV ETWTEKDQID 360

ITTNPVQMLH EFSKYRQRIK QHADAVHLIS RVTFHYKRSS LSYFGGVCSR TRGVGVNEYG 420

LPMAVAQVLS QSLAQNLGIQ WEPSSRKPKC DCTESWGGCI MEETGVSHSR KFSKCSILEY 480

RDFLQRGGGA CLFNRPTKLF EPTECGNGYV EAGEECDCGF HVECYGLCCK KCSLSNGAHC 540

SDGPCCNNTS CLFQPRGYEC RDAVNECDIT EYCTGDSGQC PPNLHKQDGY ACNQNQGRCY 600

NGECKTRDNQ CQYIWGTKAA GSDKFCYEKL NTEGTEKGNC GKDGDRWIQC SKHDVFCGFL 660 LCTNLTRAPR IGQLQGEIIP TSFYHQGRVI DCSGAHWLD DDTDVGYVED GTPCGPSMMC 720

LDRKCLQIQA LNMSSCPLDS KGKVCSGHGV CSNEATCICD FTWAGTDCSI RDPVRNLHPP 780 KDEGPKGPSA TNLIIGSIAG AILVAAIVLG GTGWGFKNVK KRRFDPTQQG PI

5 Seq ID NO : 151 DNA sequence

Nucleic Acid Accession ft : NM_023915 Coding sequence : 250 -1326

_{- Λ} 1 11 21 31 41 51

10 I I I I I I

GGCACGAGGG TTTCGTTTTC ATGCTTTACC AGAAAATCCA CTTCCCTGCC GACCTTAGTT 60

TCAAAGCTTA TTCTTAATTA GAGACAAGAA ACCTGTTTCA ACTTGAAGAC ACCGTATGAG 120

GTGAATGGAC AGCCAGCCAC CACAATGAAA GAAATCAAAC CAGGAATAAC CTATGCTGAA 180

CCCACGCCTC AATCGTCCCC AAGTGTTTCC TGACACGCAT CTTTGCTTAC AGTGCATCAC 240

15 AACTGAAGAA TGGGGTTCAA CTTGACGCTT GCAAAATTAC CAAATAACGA GCTGCACGGC 300

CAAGAGAGTC ACAATTCAGG CAACAGGAGC GACGGGCCAG GAAAGAACAC CACCCTTCAC 360

AATGAATTTG ACACAATTGT CTTGCCGGTG CTTTATCTCA TTATATTTGT GGCAAGCATC 420

TTGCTGAATG GTTTAGCAGT GTGGATCTTC TTCCACATTA GGAATAAAAC CAGCTTCATA 480

TTCTATCTCA AAAACATAGT GGTTGCAGAC CTCATAATGA CGCTGACATT TCCATTTCGA 540 0 ATAGTCCATG ATGCAGGATT TGGACCTTGG TACTTCAAGT TTATTCTCTG CAGATACACT 600

TCAGTTTTGT TTTATGCAAA CATGTATACT TCCATCGTGT TCCTTGGGCT GATAAGCATT 660

GATCGCTATC TGAAGGTGGT CAAGCCATTT GGGGACTCTC GGATGTACAG CATAACCTTC 720

ACGAAGGTTT TATCTGTTTG TGTTTOGGTG ATCATGGCTG TTTTGTCTTT GCCAAACATC 780

ATCCTGACAA ATGGTCAGCC AACAGAGGAC AATATCCATG ACTGCTCAAA ACTTAAAAGT 840 5 CCTTTGGGGG TCAAATGGCA TACGGCAGTC ACCTATGTGA ACAGCTGCTT GTTTGTGGCC 900

GTGCTGGTGA TTCTGATCGG ATGTTACATA GCCATATCCA GGTACATCCA CAAATCCAGC 960

AGGCAATTCA TAAGTCAGTC AAGCCGAAAG CGAAAACATA ACCAGAGCAT CAGGGTTGTT 1020

GTGGCTGTGT TTTTTACCTG CTTTCTACCA TATCACTTGT GCAGAATTCC TTTTACTTTT 1080

AGTCACTTAG ACAGGCTTTT AGATGAATCT GCACAAAAAA TCCTATATTA CTGCAAAGAA 1140 0 ATTACACTTT TCTTGTCTGC GTGTAATGTT TGCCTGGATC CAATAATTTA CTTTTTCATG 1200

TGTAGGTCAT TTTCAAGAAG GCTGTTCAAA AAATCAAATA TCAGAACCAG GAGTGAAAGC 1260

ATCAGATCAC TGCAAAGTGT GAGAAGATCG GAAGTTCGCA TATATTATGA TTACACTGAT 1320

GTGTAGGCCT TTTATTGTTT GTTGGAATCG ATATGTACAA AGTGTAAATA AATGTTTCTT 1380 TTCATTATCC TTAAAAAAAA AA 5

Seq ID NO: 152 Protein sequence : Protein Accession # : NP_076404 0 1 11 21 31 41 51

I I I I I I

MGFNLTLAKL PNNELHGQES HNSGNRSDGP GKNTTLHNEF DTIVLPVLYL IIFVASILLN 60

GLAVWIFFHI RNKTSFIFYL KNIWADLIM TLTFPFRIVH DAGFGPWYFK FILCRYTSVL 120

FYANMYTSIV FLGLISIDRY LKWKPFGDS RMYSITFTKV LSVCVWVIMA VLSLPNIILT 180 5 NGQPTEDNIH DCSKLKSPLG VKWHTAVTYV NSCLFVAVLV ILIGCYIAIS RYIHKSSRQF 240

ISQSSRKRKH NQSIR WAV FFTCFLPYHL CRIPFTFSHL DRLLDESAQK ILYYCKEITL 300 FLSACNVCLD PIIYFFMCRS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR IYYDYTDV

- Seq ID NO: 153 DNA sequence U Nucleic Acid Accession ft: D80008.1 Coding sequence: 149-739

1 11 21 31 41 51 5 I 1 1 I I 1

GTTCGGCGCC AAAGCGCGGA GCGGAGGCCG AGGCGAGAGC CTGGCGCTGT AGGACTAGAA 60

CGAAAGGAGT GAGGCGCCGA GAGCCCAGAT ACCATTTTGG CGTGAGAGCT GGTGGTTGGC 120

AAGGCCGCGG GAGTGGGAAG CGTCCGCCAT GTTCTGCGAA AAAGCCATGG AACTGATCCG 180

CGAGCTGCAT CGCGCGCCCG AAGGGCAACT GCCTGCCTTC AACGAGGATG GACTCAGACA 240

AGTTCTGGAG GAGATGAAAG CTTTGTATGA ACAAAACCAG TCTGATGTGA ATGAAGCAAA 300 0 GTCAGGTGGA CGAAGTGATT TGATACCAAC TATCAAATTT CGACACTGTT CTCTGTTAAG 360

AAATCGACGC TGCACTGTAG CATACCTGTA TGACCGCTTG CTTCGGATCA GAGCACTCAG 420

ATGGGAATAT GGTAGCGTCT TGCCAAATGC ATTACGATTT CACATGGCTG CTGAAGAAAT 480

GGAGTGGTTT AATAATTATA AAAGATCTCT TGCTACTTAT ATGAGGTCAC TGGGAGGAGA 540

TGAAGGTTTG GACATTACAC AGGATATGAA ACCACCAAAA AGCCTATATA TTGAAGTCCG 600 5 GTGTCTAAAA GACTATGGAG AATTTGAAGT TGATGATGGC ACTTCAGTCC TATTAAAAAA 660

AAATAGCCAG CACTTTTTAC CTCGATGGAA ATGTGAGCAG CTGATCAGAC AAGGAGTCCT 720

GGAGCACATC CTGTCATGAC CATGCGCCGA GGCACTTCCA GGCTTCACTC AACTCATGGA 780

CTCCTCTGTA CTCACTCTCT CCACCACTCC CTTCACCTCC CTCTTTGATT TTAGAAGCTA 840

TAGACATTGT TTAAGATAAC TAAGAATACT TGGCTAAGAA GTATAATTTG CTAACTATTA 900 0 AGGACTTTCT TTTTTTAATG TTGTACACTA TTCTTCCTAC TCTTTTTTGG TTTTGGTTTT 960

GTTTTGTAGA GACTGTCTCA CTATGTTGCC CAAGCTGGTC TCAAACTCCT GGCCTCAAGC 1020

AGTCCTCCCA CCTTAGCTTC TCAAAGTGTT GAGATCACAG GCGTGAGCCA CTGCACCCGG 1080

CCCCTACTCC TTTTTCTAAT AAGCTGTATC TGTAATCACA GCATTCCTAC AGTTGTTACA 1140

GTGTGTTTTT TAAATGAAAG TAAACATGGT TACATTTGAA TCTCTTAAAT AAGCAGTCAC 1200 5 TTGGCTGGAC AGGAAGAAGG TAGATCCTGT GTGTCTTGTT TTCTGGTCAT GTGTATTGTA 1260

CAAGCTAGAG AGCTGAATTT CTGAGATACA CATTTTCAAA TCACATGCAA GTGAAGATGA 1320

TGGTCTGTAG AAATTTTCAG TATATATAAT GTTTAATGAC ATACTAATTT ATCATCTGGC 1380

TATTTGGGAA GGAAGGACAC ACATGGATTT TGCACATTTC CACCATGGTG GCTGGTGTGG 1440

CTTGTGGCTA TGGGGTGATC ACCAGTATCA CCACTTTGGA AGGGGACAGT GAAATTGGGG 1500 0 CTAGAGAAGG AACTTTGTAC AGTTTTCCCT GAGATTCAGA TTGACTGAAA AGTCACATGA 1560

AGAGTTGATT GTCTTTTAAT GGTATGTTTT AAACAGCTGA CATTTTAAAT TTTGATGAAA 1620

TCCAGTTTAT TCGTTTGTTC TTTTATGCTT TGGGTGTTGC ATCCGAGAAA TCTTTTCCCA 1680

TCCCAAGATC ACAATTTTTT TTCCTTTTTA CTTCTAGAAG TGTTATAATT TTAAGCTTTA 1740

TACTTTGGTC TATGACCCGT TTTTTTTTTT GTTTTGTTTT GTTTTTTCGT TTGTTTCTTT 1800 5 GTTTTGAGAT GGAGTCTTGT TCTGTCACCC AGGCTGGGGT GCAGTGGCGT GATCTTGGCT 1860

CACTGCAATC TCTATCCCCT GGGTTCAAGT GATTCTCTTG TCTCAGCCTC CCAAGTAGCT 1920

GGGATTACAG GCACAGGCCG CCACGCCTGG CTAATTTTTG TATTTTTAGT AGAGACAGAG 1980 TTTTACCATG TTGGCCAGGC TGGTTTCAAA CTCCTGACCT CAAGTGACCC ACCTTGGCCT 2040

CCCAAAGTTT TGGGATTACA AGTGTGGGCC ACCGCGGCCA GCCTATGATC CATTTTGAAT 2100

GAATTTTTTA TATGGTGCAA GGTGTCAATC CACCTTCACT TTTTCTTGGG AA ATAGATA 2160

TCCAGCTGTT TCACTACCAT TTTTTGAAAG GACTGCCCTT TGCTCTATCA CCTTTGCATT 2220

TTTGTTAAAA AGTAGTTGTC AATGTATATG TGGGTTTATT TCAGGACTCT GTTTTGTTCC 2280

ATTGACCTGT TTTTCTCTCC TGAATGCCAA TACCATATTT GTATGTAGTG TATGTAATTT 2340

TCTAATAATT CTTGAAACAG ATAGTATTAA TGTGTCATAT TTTTGCTGTT GTTTGTATTT 2400

TTTGTAGAGA TGGGGTTTCA CCGTGTTGGC CAGGCTGTGT TGAACTCCTG AGCTAAAGCA 2460

ATACACTTGC CTCGTCCTCC CCATGTGCTG GGATTACAGG CGTGAGCCTT GGTGCTGGCC 2520

10 CAGTGTACCA CATTTCTTTT TGAGATTTGT TTTGGCTATG TTAAGTCCTT TGCTTTTGAT 2580

GTGAAATTTG GGAACAGGCA GGGTGTGGTG GCTTATGCCT GTAATCCTAG AACTTTGGGA 2640

GGCCTAGATG GGTGGATCAC TTGAGCTCAG GAGTTCCAGA CCAGCCCGGG CCTATGGCAA 2700

AACTCCGTCT CTACAAAAAA TAGAAAAAAT TAGCCAGGTG TGGTGGTGCA TGCCTGTAGT 2760

CACAGTTACA CGGCAGGCTG AGGTGGGAGG ATCACTTGAA CCCCAGAGGT CAAGACTGCA 2820

15 GTGAGCTGAG ATCACACCAC TGTACTCCAG CCTGGGTGAC AAAGTGAGAC TCTATCTCAA 2880

AAAGAAATTA GGATCAATTT GTCAATTTCT ACAACAACAA CAACAAAAAC CCCTGTTGGG 2940

CACCTTGATT GAGATTGCAT TGAATTTATA TAAAACTGTT GGGAGAATTG ACATCTTAAT 3000

AATATTGAGT CTTCTGGCCT ATAAACAAGG TCTGTCTTCC TAGGTATTAA TGTTTTGTCT 3060

TCTATTTCTC TTAATAATCT TTTGTAGTTT TCAGTGTACA GGTCTACCAT GTCAGCATTT 3120

20 CATAGTTTTG ATGCTAAATG GTATTTTAAA ATTTCAAATT CTAACCACTT GTTGCTAGTA 3180

AATAGAAATA CAATTGATGT TGAACTTGTA TCCTTCAGCC TTGCTAAACT GTGAGTTCTC 3240

ATGGTGTTTT TGTAAATTAC ATCAACAGTC ATGTGTTCTA TGAATAAAGA GTTTTACTCC 3300 TC

25 Seq ID NO: 154 Protein sequence: Protein Accession ft: BAA11503.1

1 11 21 31 41 51

~_n I I I I I I

3V MFCEKAMELI RELHRAPEGQ LPAFNEDGLR QVLEEMKALY EQNQSDVNEA KSGGRSDLIP 60

TIKFRHCSLL RNRRCTVAYL YDRLLRIRAL RWEYGSVLPN ALRFHMAAEE MEWFNNYKRS 120 LATYMRSLGG DEGLDITQDM KPPKSLYIEV RCLKDYGEFE VDDGTSVLLK KNSQHFLPRW 180 KCEQLIRQGV LEHILS

35 Seq ID NO: 155 DNA sequence

Nucleic Acid Accession #: Eos sequence Coding sequence: 149-709

11 21 31 41 51

40 i I

GTTCGGCGCC A IAAGCGCGGA GCGGAGGCCG I

AGGCGAGAGC CTGGCGCTGT A IGGACTAGAA 60 CGAAAGGAGT GAGGCGCCGA GAGCCCAGAT ACCATTTTGG CGTGAGAGCT GGTGGTTGGC 120 AAGGCCGCGG GAGTGGGAAG CGTCCGCCAT GTTCTGCGAA AAAGCCATGG AACTGATCCG 180 CGAGCTGCAT CGCGCGCCCG AAGGGCAACT GCCTGCCTTC AACGAGGATG GACTCAGACA 240

45 AGTTCTGGAG GAGATGAAAG CTTTGTATGA ACAAAACCAG TCTGATGTGA ATGAAGCAAA 300 GTCAGGTGGA CGAAGTGATT TGATACCAAC TATCAAATTT CGACACTGTT CTCTGTTAAG 360 AAATCGACGC TGCACTGTAG CATACCTGTA TGACCGCTTG CTTCGGATCA GAGCACTCAG 420 ATGGGAATAT GGTAGCGTCT TGCCAAATGC ATTACGATTT CACATGGCTG CTGAAGAAAT 480 GGAGTGGTTT AATAATTATA AAAGATCTCT TGCTACTTAT ATGAGGTCAC TGGGAGGAGA 540

50 TGAAGGTTTG GACATTACAC AGGATATGAA ACCACCAAAA AGCCTATATA TTGAAGCTGG 600 ATGCAGTGGC GCGATCTCGG CTCAACCTGC AACCTCCACC TCCCAGGTTC ACCTCAACTG 660 CAACCTCCAC CTCCCAGGTC CGGTGTCTAA AAGACTATGG AGAATTTGAA GTTGATGATG 720 GCACTTCAGT CCTATTAAAA AAAAATAGCC AGCACTTTTT ACCTCGATGG AAATGTGAGC 780 AGCTGATCAG ACAAGGAGTC CTGGAGCACA TCCTGTCATG ACCATGCGCC GAGGCACTTC 840

55 CAGGCTTCAC TCAACTCATG GACTCCTCTG TACTCACTCT CTCCACCACT CCCTTCACCT 900 CCCTCTTTGA TTTTAGAAGC TATAGACATT GTTTAAGATA ACTAAGAATA CTTGGCTAAG 960 AAGTATAATT TGCTAACTAT TAAGGACTTT CTTTTTTTAA TGTTGTACAC TATTCTTCCT 1020 ACTCTTTTTT GGTTTTGGTT TTGTTTTGTA GAGACTGTCT CACTATGTTG CCCAAGCTGG 1080 TCTCAAACTC CTGGCCTCAA GCAGTCCTCC CACCTTAGCT TCTCAAAGTG TTGAGATCAC 1140 0 AGGCGTGAGC CACTGCACCC GGCCCCTACT CCTTTTTCTA ATAAGCTGTA TCTGTAATCA 1200 CAGCATTCCT ACAGTTGTTA CAGTGTGTTT TTTAAATGAA AGTAAACATG GTTACATTTG 1260 AATCTCTTAA ATAAGCAGTC ACTTGGCTGG ACAGGAAGAA GGTAGATCCT GTGTGTCTTG 1320 TTTTCTGGTC ATGTGTATTG TACAAGCTAG AGAGCTGAAT TTCTGAGATA CACATTTTCA 1380 AATCACATGC AAGTGAAGAT GATGGTCTGT AGAAATTTTC AGTATATATA ATGTTTAATG 1440 5 ACATACTAAT TTATCATCTG GCTATTTGGG AAGGAAGGAC ACACATGGAT TTTGCACATT 1500 TCCACCATGG TGGCTGGTGT GGCTTGTGGC TATGGGGTGA TCACCAGTAT CACCACTTTG 1560 GAAGGGGACA GTGAAATTGG GGCTAGAGAA GGAACTTTGT ACAGTTTTCC CTGAGATTCA 1620 GATTGACTGA AAAGTCACAT GAAGAGTTGA TTGTCTTTTA ATGGTATGTT TTAAACAGCT 1680 GACATTTTAA ATTTTGATGA AATCCAGTTT ATTCGTTTGT TCTTTTATGC TTTGGGTGTT 1740 0 GCATCCGAGA AATCTTTTCC CATCCCAAGA TCACAATTTT TTTTCCTTTT TACTTCTAGA 1800 AGTGTTATAA TTTTAAGCTT TATACTTTGG TCTATGACCC GTTTTTTTTT TTGTTTTGTT 1860 TTGTTTTTTC GTTTGTTTCT TTGTTTTGAG ATGGAGTCTT GTTCTGTCAC CCAGGCTGGG 1920 GTGCAGTGGC GTGATCTTGG CTCACTGCAA TCTCTATCCC CTGGGTTCAA GTGATTCTCT 1980 TGTCTCAGCC TCCCAAGTAG CTGGGATTAC AGGCACAGGC CGCCACGCCT GGCTAATTTT 2040 5 TGTATTTTTA GTAGAGACAG AGTTTTACCA TGTTGGCCAG GCTGGTTTCA AACTCCTGAC 2100 CTCAAGTGAC CCACCTTGGC CTCCCAAAGT TTTGGGATTA CAAGTGTGGG CCACCGCGGC 2160 CAGCCTATGA TCCATTTTGA ATGAATTTTT TATATGGTGC AAGGTGTCAA TCCACCTTCA 2220 CTTTTTCTTG GGAATATAGA TATCCAGCTG TTTCACTACC ATTTTTTGAA AGGACTGCCC 2280 TTTGCTCTAT CACCTTTGCA TTTTTGTTAA AAAGTAGTTG TCAATGTATA TGTGGGTTTA 2340 0 TTTCAGGACT CTGTTTTGTT CCATTGACCT GTTTTTCTCT CCTGAATGCC AATACCATAT 2400 TTGTATGTAG TGTATGTAAT TTTCTAATAA TTCTTGAAAC AGATAGTATT AATGTGTCAT 2460 ATTTTTGCTG TTGTTTGTAT TTTTTGTAGA GATGGGGTTT CACCGTGTTG GCCAGGCTGT 2520 GTTGAACTCC TGAGCTAAAG CAATACACTT GCCTCGTCCT CCCCATGTGC TGGGATTACA 2580 GGCGTGAGCC TTGGTGCTGG CCCAGTGTAC CACATTTCTT TTTGAGATTT GTTTTGGCTA 2640 5 TGTTAAGTCC TTTGCTTTTG ATGTGAAATT TGGGAACAGG CAGGGTGTGG TGGCTTATGC 2700 CTGTAATCCT AGAACTTTGG GAGGCCTAGA TGGGTGGATC ACTTGAGCTC AGGAGTTCCA 2760 GACCAGCCCG GGCCTATGGC AAAACTCCGT CTCTACAAAA AATAGAAAAA ATTAGCCAGG 2820 TGTGGTGGTG CATGCCTGTA GTCACAGTTA CACGGCAGGC TGAGGTGGGA GGATCACTTG 2880

AACCCCAGAG GTCAAGACTG CAGTGAGCTG AGATCACACC ACTGTACTCC AGCCTGGGTG 2940

ACAAAGTGAG ACTCTATCTC AAAAAGAAAT TAGGATCAAT TTGTCAATTT CTACAACAAC 3000

AACAACAAAA ACCCCTGTTG GGCACCTTGA TTGAGATTGC ATTGAATTTA TATAAAACTG 3060

TTGGGAGAAT TGACATCTTA ATAATATTGA GTCTTCTGGC CTATAAACAA GGTCTGTCTT 3120

CCTAGGTATT AATGTTTTGT CTTCTATTTC TCTTAATAAT CTTTTGTAGT TTTCAGTGTA 3180

CAGGTCTACC ATGTCAGCAT TTCATAGTTT TGATGCTAAA TGGTATTTTA AAATTTCAAA 3240

TTCTAACCAC TTGTTGCTAG TAAATAGAAA TACAATTGAT GTTGAACTTG TATCCTTCAG 3300

CCTTGCTAAA CTGTGAGTTC TCATGGTGTT TTTGTAAATT ACATCAACAG TCATGTGTTC 3360 TATGAATAAA GAGTTTTACT CCTTC

Seq ID NO: 156 Protein sequence: Protein Accession ft: Eos sequence

1 11 21 31 41 51

I I I I I I

MFCEKAMELI RELHRAPEGQ LPAFNEDGLR QVLEEMKALY EQNQSDVNEA KSGGRSDLIP 60

TIKFRHCSLL RNRRCTVAYL YDRLLRIRAL RWEYGSVLPN ALRFHMAAEE MEWFNNYKRS 120

LATYMRSLGG DEGLDITQDM KPPKSLYIEA GCSGAISAQP ATSTSQVHLN CNLHLPGPVS 180 KRLWRI

Seq ID NO: 157 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 148-621

1 11 21 31 41 51

I I I I I I

TTCGGCGCCA AAGCGCGGAG CGGAGGCCGA GGCGAGAGCC TGGCGCTGTA GGACTAGAAC' 60

GAAAGGAGTG AGGCGCCGAG AGCCCAGATA CCATTTTGGC GTGAGAGCTG GTGGTTGGCA 120

AGGCCGCGGG AGTGGGAAGC GTCCGCCATG TTCTGCGAAA AAGCCATGGA ACTGATCCGC 180

GAGCTGCATC GCGCGCCCGA AGGGCAACTG CCTGCCTTCA ACGAGGATGG ACTCAGACAA 240

GTTCTGGAGG AGATGAAAGC TTTGTATGAA CAAAACCAGT CTGATGTGAA TGAAGCAAAG 300

TCAGGTGGAC GAAGTGATTT GATACCAACT ATCAAATTTC GACACTGTTC TCTGTTAAGA 360

AATCGACGCT GCACTGTAGC ATACCTGTAT GACCGCTTGC TTCGGATCAG AGCACTCAGA 420

TGGGAATATG GTAGCGTCTT GCCAAATGCA TTACGATTTC ACATGGCTGC TGAAGAAGTC 480

CGGTGTCTAA AAGACTATGG AGAATTTGAA GTTGATGATG GCACTTCAGT CCTATTAAAA 540

AAAAATAGCC AGCACTTTTT ACCTCGATGG AAATGTGAGC AGCTGATCAG ACAAGGAGTC 600

CTGGAGCACA TCCTGTCATG ACCATGCGCC GAGGCACTTC CAGGCTTCAC TCAACTCATG 660

GACTCCTCTG TACTCACTCT CTCCACCACT CCCTTCACCT CCCTCTTTGA TTTTAGAAGC 720

TATAGACATT GTTTAAGAT ACTAAGAATA CTTGGCTAAG AAGTATAATT TGCTAACTAT 780

TAAGGACTTT CTTTTTTTAA TGTTGTACAC TATTCTTCCT ACTCTTTTTT GGTTTTGGTT 840

TTGTTTTGTA GAGACTGTCT CACTATGTTG CCCAAGCTGG TCTCAAACTC CTGGCCTCAA 900

GCAGTCCTCC CACCTTAGCT TCTCAAAGTG TTGAGATCAC AGGCGTGAGC CACTGCACCC 960

GGCCCCTACT CCTTTTTCTA ATAAGCTGTA TCTGTAATCA CAGCATTCCT ACAGTTGTTA 1020

CAGTGTGTTT TTTAAATGAA AGTAAACATG GTTACATTTG AATCTCTTAA ATAAGCAGTC 1080

ACTTGGCTGG ACAGGAAGAA GGTAGATCCT GTGTGTCTTG TTTTCTGGTC ATGTGTATTG 1140

TACAAGCTAG AGAGCTGAAT TTCTGAGATA CACATTTTCA AATCACATGC AAGTGAAGAT 1200

GATGGTCTGT AGAAATTTTC AGTATATATA ATGTTTAATG ACATACTAAT TTATCATCTG 1260

GCTATTTGGG AAGGAAGGAC ACACATGGAT TTTGCACATT TCCACCATGG TGGCTGGTGT 1320

GGCTTGTGGC TATGGGGTGA TCACCAGTAT CACCACTTTG GAAGGGGACA GTGAAATTGG 1380

GGCTAGAGAA GGAACTTTGT ACAGTTTTCC CTGAGATTCA GATTGACTGA AAAGTCACAT 1440

GAAGAGTTGA TTGTCTTTTA ATGGTATGTT TTAAACAGCT GACATTTTAA ATTTTGATGA 1500

AATCCAGTTT ATTCGTTTGT TCTTTTATGC TTTGGGTGTT GCATCCGAGA AATCTTTTCC 1560

CATCCCAAGA TCACAATTTT TTTTCCTTTT TACTTCTAGA AGTGTTATAA TTTTAAGCTT 1620

TATACTTTGG TCTATGACCC GTTTTTTTTT TTGTTTTGTT TTGTTTTTTC GTTTGTTTCT 1680

TTGTTTTGAG ATGGAGTCTT GTTCTGTCAC CCAGGCTGGG GTGCAGTGGC GTGATCTTGG 1740

CTCACTGCAA TCTCTATCCC CTGGGTTCAA GTGATTCTCT TGTCTCAGCC TCCCAAGTAG 1800

CTGGGATTAC AGGCACAGGC CGCCACGCCT GGCTAATTTT TGTATTTTTA GTAGAGACAG 1860

AGTTTTACCA TGTTGGCCAG GCTGGTTTCA AACTCCTGAC CTCAAGTGAC CCACCTTGGC 1920

CTCCCAAAGT TTTGGGATTA CAAGTGTGGG CCACCGCGGC CAGCCTATGA TCCATTTTGA 1980

ATGAATTTTT TATATGGTGC AAGGTGTCAA TCCACCTTCA CTTTTTCTTG GGAATATAGA 2040

TATCCAGCTG TTTCACTACC ATTTTTTGAA AGGACTGCCC TTTGCTCTAT CACCTTTGCA 2100

TTTTTGTTAA AAAGTAGTTG TCAATGTATA TGTGGGTTTA TTTCAGGACT CTGTTTTGTT 2160

CCATTGACCT GTTTTTCTCT CCTGAATGCC AATACCATAT TTGTATGTAG TGTATGTAAT 2220

TTTCTAATAA TTCTTGAAAC AGATAGTATT AATGTGTCAT ATTTTTGCTG TTGTTTGTAT 2280

TTTTTGTAGA GATGGGGTTT CACCGTGTTG GCCAGGCTGT GTTGAACTCC TGAGCTAAAG 2340

CAATACACTT GCCTCGTCCT CCCCATGTGC TGGGATTACA GGCGTGAGCC TTGGTGCTGG 2400

CCCAGTGTAC CACATTTCTT TTTGAGATTT GTTTTGGCTA TGTTAAGTCC TTTGCTTTTG 2460

ATGTGAAATT TGGGAACAGG CAGGGTGTGG TGGCTTATGC CTGTAATCCT AGAACTTTGG 2520

GAGGCCTAGA TGGGTGGATC ACTTGAGCTC AGGAGTTCCA GACCAGCCCG GGCCTATGGC 2580

AAAACTCCGT CTCTACAAAA AATAGAAAAA ATTAGCCAGG TGTGGTGGTG CATGCCTGTA 2640

GTCACAGTTA CACGGCAGGC TGAGGTGGGA GGATCACTTG AACCCCAGAG GTCAAGACTG 2700

CAGTGAGCTG AGATCACACC ACTGTACTCC AGCCTGGGTG ACAAAGTGAG ACTCTATCTC 2760

AAAAAGAAAT TAGGATCAAT TTGTCAATTT CTACAACAAC AACAACAAAA ACCCCTGTTG 2820

GGCACCTTGA TTGAGATTGC ATTGAATTTA TATAAAACTG TTGGGAGAAT TGACATCTTA 2880

ATAATATTGA GTCTTCTGGC CTATAAACAA GGTCTGTCTT CCTAGGTATT AATGTTTTGT 2940

CTTCTATTTC TCTTAATAAT CTTTTGTAGT TTTCAGTGTA CAGGTCTACC ATGTCAGCAT 3000

TTCATAGTTT TGATGCTAAA TGGTATTTTA AAATTTCAAA TTCTAACCAC TTGTTGCTAG 3060

TAAATAGAAA TACAATTGAT GTTGAACTTG TATCCTTCAG CCTTGCTAAA CTGTGAGTTC 3120

TCATGGTGTT TTTGTAAATT ACATCAACAG TCATGTGTTC TATGAATAAA GAGTTTTACT 3180 CCTTC

Seq ID NO: 158 Protein sequence: Protein Accession ft: Eos sequence

21 41 51 MFCEKAMELI RELHRAPEGQ LPAFNEDGLR QVLEEMKALY EQNQSDVNEA KSGGRSDLIP 60 TIKFRHCSLL RNRRCTVAYL YDRLLRIRAL RWEYGSVLPN ALRFHMAAEE VRCLKDYGEF 120 EVDDGTSVLL KKNSQHFLPR WKCEQLIRQG VLEHILS

5 Seq ID NO: 159 DNA sequence

Nucleic Acid Accession ft: Eos sequence Coding sequence: 149-229

., - 1 11 21 31 41 51

10 i i i i i i

GTTCGGCGCC AAAGCGCGGA GCGGAGGCCG AGGCGAGAGC CTGGCGCTGT AGGACTAGAA 60

CGAAAGGAGT GAGGCGCCGA GAGCCCAGAT ACCATTTTGG CGTGAGAGCT GGTGGTTGGC 120

AAGGCCGCGG GAGTGGGAAG CGTCCGCCAT GTTCTGCGAA AAAGCCATGG AACTGATCCG 180

CGAGCTGCAT CGCGCGCCCG AAGGGCAACT GCCTGCCTTC AACAATTAGC TGGGTGTGGT 240

15 GGCACACACC TGTAGTCCCA GCAACTTAGG AGGCTGAAGT GAGAGGATTG CATGGCTCCA 300

GGAAGTTGAA ACTGCAGTGA ACTGTGGTCA CGCTATTACA CTCCAGCCTG GGTGACAGAC 360

TGAATCCCTG TCTCAAAAAG GAAAAGGAGG ATGGACTCAG ACAAGTTCTG GAGGAGATGA 420

AAGCTTTGTA TGAACAAAAC CAGTCTGATG TGTTCTCTGT TAAGAAATCG ACGCTGCACT 480 GTAGCATACC TGTATGACCG CTTGCTTCGG ATCAGAGCAC TCAGATGG

20

Seq ID NO: 160 Protein sequence: Protein Accession ft: Eos sequence

__ 1 11 21 31 41 51

25 i i i i i i

ATGTTCTGCG AAAAAGCCAT GGAACTGATC CGCGAGCTGC ATCGCGCGCC CGAAGGGCAA 60 CTGCCTGCCT TCAACAATTA G

Seq ID NO: 161 DNA sequence

30 Nucleic Acid Accession ft: U10694 Coding sequence: 1333-2280

1 11 21 31 41 51

35 I I I I I I

GGATCCGGCC GGATCTCAGG GAGGTGAGGA CTTTGTTCTC AGAGGGTGTG TGTGGACAAA 60

ACAGGGAGGC CCTGTGTTCG ACAGACACAG TGGTCCCAGG ATTGGAGAGC AGTCCAGGTG 120

AGGAACCTAA GGGAGGATCG AGGGTACCTC CAGGCCAGAG AAACTCTCAG ATCAAGAGAG 180

TTTGCCCTGC CCCTACTGTC ACCCCAGAGA GCCCGGGCAG GGCTGTCTGC TGAGGTCCCT 240

CCTTTATCCT GGGATCACTG GTGTCGGGGA GGGCTGGCCT TGGTCTGAGG GGGCTGCACT 300 0 CACGTCAGCA GAGGGAGGGT CCCAGGCCCT GCCAGGAGTC CAGGTGCAGA CTGAGGGGAC 360

CCCACTCACC AAACACAGAG GACCTAGCCC CACCCTGCCC CTTGTGTCAG CTGAGGGAAG 420

CCGCTGGGTG GATGGACTCC CCTCACTTCC TCTTCAGGTG TCTCCTGGAG ATAGGGCCTC 480

AGGTCAACAG AGGGAGGGTT CCAGACCCTG CAGGCATCAA GATGAGGACC AGGCAGTATC 540

CTCACCCCAG GACACATGGA CCCCATTGAA TTTAGACATC TCTTACTGTA CTTCCGAGGA 600 5 AACCCTGGGC AGGTGTGGGC AGATGTTGGT TGGGGCATGT CCTTCTGTTC CATATCAGGG 660

ATGTGAGCTC CTGATCTGAG AGACTCTCAG GCAAGTAGAG GAGTAGAGTC CAGTCCCTGC 720

CAGGAGAAAG GTCAGGGCCC TGAGTGAGCG CAGAGGGGAC CATCCACCCC AAAAGTGTGT 780

AGAACTCAAG AGTGTCCAGC CCGCCCTCTT GACAGCACTG AGGGACCGGG GCTCTGCCTG 840

CAGTCTGCAG CCTAAGGGCC CCTCGATTCC TCTTCCAGGA GCTCCAGGAA GCAGGCAGGC 900 0 CTTGGTCTGA GACAGTGTCC TCAGGTCGCA GAGCAGAGGA GACCCAGGCA GTGTCAGCAG 960

TGAAGGTGAA GTGTTCACCC TGAATGTGCA CCAAGGGCCC CACCTGCCCC AGCACACATG 1020

GGACCCCATA GCACCTGGCC CCATTCCCCC TACTGTCACT CATAGAGCCT TGATCTCTGC 1080

AGGCTAGCTG CACGCTGAGT AGCCCTCTCA CTTCCTCCCT CAGGTTCTCG GGACAGGCTA 1140

ACCAGGAGGA CAGGAGCCCC AAGAGGCCCC AGAGCAGCAC TGACGAAGAC CTGTAAGTCA 1200 5 GCCTTTGTTA GAACCTCCAA GGTTCGGTTC TCAGCTGAAG TCTCTCACAC ACTCCCTCTC 1260

TCCCCAGGCC TGTGGGTCTC CATCGCCCAG CTCCTGCCCA CGCTCCTGAC TGCTGCCCTG 1320

ACCAGAGTCA TCATGTCTCT CGAGCAGAGG AGTCCGCACT GCAAGCCTGA TGAAGACCTT 1380

GAAGCCCAAG GAGAGGACTT GGGCCTGATG GGTGCACAGG AACCCACAGG CGAGGAGGAG 1440

GAGACTACCT CCTCCTCTGA CAGCAAGGAG GAGGAGGTGT CTGCTGCTGG GTCATCAAGT 1500 0 CCTCCCCAGA GTCCTCAGGG AGGCGCTTCC TCCTCCATTT CCGTCTACTA CACTTTATGG 1560

AGCCAATTCG ATGAGGGCTC CAGCAGTCAA GAAGAGGAAG AGCCAAGCTC CTCGGTCGAC 1620

CCAGCTCAGC TGGAGTTCAT GTTCCAAGAA GCACTGAAAT TGAAGGTGGC TGAGTTGGTT 1680

CATTTCCTGC TCCACAAATA TCGAGTCAAG GAGCCGGTCA CAAAGGCAGA AATGCTGGAG 1740

AGCGTCATCA AAAATTACAA GCGCTACTTT CCTGTGATCT TCGGCAAAGC CTCCGAGTTC 1800 5 ATGCAGGTGA TCTTTGGCAC TGATGTGAAG GAGGTGGACC CCGCCGGCCA CTCCTACATC 1860

CTTGTCACTG CTCTTGGCCT CTCGTGCGAT AGCATGCTGG GTGATGGTCA TAGCATGCCC 1920

AAGGCCGCCC TCCTGATCAT TGTCCTGGGT GTGATCCTAA CCAAAGACAA CTGCGCCCCT 1980

GAAGAGGTTA TCTGGGAAGC GTTGAGTGTG ATGGGGGTGT ATGTTGGGAA GGAGCACATG 2040

TTCTACGGGG AGCCCAGGAA GCTGCTCACC CAAGATTGGG TGCAGGAAAA CTACCTGGAG 2100 0 TACCGGCAGG TGCCCGGCAG TGATCCTGCG CACTACGAGT TCCTGTGGGG TTCCAAGGCC 2160

CACGCTGAAA CCAGCTATGA GAAGGTCATA AATTATTTGG TCATGCTCAA TGCAAGAGAG 2220

CCCATCTGCT ACCCATCCCT TTATGAAGAG GTTTTGGGAG AGGAGCAAGA GGGAGTCTGA 2280

GCACCAGCCG CAGCCGGGGC CAAAGTTTGT GGGGTCAGGG CCCCATCCAG CAGCTGCCCT 2340

GCCCCATGTG ACATGAGGCC CATTCTTCGC TCTGTGTTTG AAGAGAGCAA TCAGTGTTCT 2400 5 CAGTGGCAGT GGGTGGAAGT GAGCACACTG TATGTCATCT CTGGGTTCCT TGTCTATTGG 2460

GTGATTTGGA GATTTATCCT TGCTCCCTTT TGGAATTGTT CAAATGTTCT TTTAATGGTC 2520

AGTTTAATGA ACTTCACCAT CGAAGTTAAT GAATGACAGT AGTCACACAT ATTGCTGTTT 2580

ATGTTATTTA GGAGTAAGAT TCTTGCTTTT GAGTCACATG GGGAAATCCC TGTTATTTTG 2640

TGAATTGGGA CAAGATAACA TAGCAGAGGA ATTAATAATT TTTTTGAAAC TTGAACTTAG 2700 0 CAGCAAAATA GAGCTCATAA AGAAATAGTG AAATGAAAAT GTAGTTAATT CTTGCCTTAT 2760

ACCTCTTTCT CTCTCCTGTA AAATTAAAAC ATATACATGT ATACCTGGAT TTGCTTGGCT 2820

TCTTTGAGCA TGTAAGAGAA ATAAAAATTG AAAGAATAAT TTTTCCTGTT CACTGGCTCA 2880 TTTTTTCTTC AGACACGCAC TGAACATCTG TTATTCGGAA CACCCTGGGT T 5

Seq ID NO: 162 Protein sequence: Protein Accession ft: AAA68877.1 1 11 21 31 41 51

I I I I I I

MSLEQRSPHC KPDEDLEAQG EDLGLMGAQE PTGEEEETTS SSDSKEEEVS AAGSSSPPQS 60

PQGGASSSIS VYYTLWSQFD EGSSSQEEEE PSSSVDPAQL EFMFQEALKL KVAELVHFLL 120

HKYRVKEPVT KAEMLESVIK NYKRYFPVIF GKASEFMQVI FGTDVKEVDP AGHSYILVTA 180

LGLSCDSMLG DGHSMPKAAL LIIVLGVILT KDNCAPEEVI WEALSVMGVY VGKEHMFYGE 240

PRKLLTQDWV QENYLEYRQV PGSDPAHYEF LWGSKAHAET SYEKVINYLV MLNAREPICY 300 PSLYEEVLGE EQEGV

Seq ID NO: 163 DNA sequence Nucleic Acid Accession ft: AF292100 Coding sequence: 30-809

1 11 21 31 41 51

I I I I I I

GGGGGGGGAG AGGCCTGGAG GACACCAACA TGAACAAGTT GAAATCATCG CAGAAGGATA 60

AAGTTCGTCA GTTTATGATC TTCACACAAT CTAGTGAAAA AACAGCAGTA AGTTGTCTTT 120

CTCAAAATGA CTGGAAGTTA GATGTTGCAA CAGATAATTT TTTCCAAAAT CCTGAACTTT 180

ATATACGAGA GAGTGTAAAA GGATCATTGG ACAGGAAGAA GTTAGAACAG CTGTACAATA 240

GATACAAAGA CCCTCAAGAT GAGAATAAAA TTGGAATAGA TGGCATACAG CAGTTCTGTG 300

ATGACCTGGC ACTCGATCCA GCCAGCATTA GTGTGTTGAT TATTGCGTGG AAGTTCAGAG 360

CAGCAACACA GTGCGAGTTC TCCAAACAGG AGTTCATGGA TGGCATGACA GAATTAGGAT 420

GTGACAGCAT AGAACAACTA AAGGCCCAGA TACCCAAGAT GGAACAAGAA TTGAAAGAAC 480

CAGGACGATT TAAGGATTTT TACCAGTTTA CTTTTAATTT TGCAAAGAAT CCAGGACAAA 540

AAGGATTAGA TCTAGAAATG GCCATTGCCT ACTGGAACTT AGTGCTTAAT GGAAGATTTA 600

AATTCTTAGA CTTATGGAAT AAATTTTTGT TGGAACATCA TAAACGATCA ATACCAAAAG 660

ACACTTGGAA TCTTCTTTTA GACTTCAGTA CGATGATTGC AGATGACATG TCTAATTATG 720

ATGAAGAAGG AGCATGGCCT GTTCTTATTG ATGACTTTGT GGAATTTGCA CGCCCTCAAA 780

TTGCTGGGAC AAAAAGTACA ACAGTGTAGC ACTAAAGGAA CCTTTTAGAA TGTACATAGT 840

CTGTACAATA AATACAACAG AAAATTGCAC AGTCAATTTC TGCTGGCTGG ACTGAACTGA 900

AGATCAATCC TCACAATTCA GACTGAGGGT TGAGACAAAA CTTTAAGGAT ACATCTTGGA 960

CCATATCGTA TTTCATTCTT CTAATGGTGG TTTGGGCTTG TCTTCTAGTC TGGGCCGCTC 1020

TAAACATTTA TAATTCCAAC ATTGTGGATT TCATCTTATA TCTGTGGACC ATCCTAGTTT 1080

ATTCTCCCAT AAGTCTTAGA AGCTTTATGG TGATTATTTT GAGGTTTTCA TTCTCGCATA 1140

AAGCACAATG CTGTCTTCAT CAGAAAACAG TTGGCATAAG AATTAAACAT ATGAACATCA 1200

CAAAACAATT TATAAAAACT TCTTAAATAT ACGCTTTGGG CTAGTTGCAA AGACTATGCT 1260

AATAGCACTT CCAGTGAGAG TGATATATTT AAGTGTACTG GATCTGGAAT GGTGTTTTGG 1320

TTTGGGGGGA ATTTTTTTTT TTTCCTGGCA AATCACATAT GTTGTTGATG TGAGTATCTG 1380

ATGAAAAAAC AATGTCAGAA TAACCGACAT GAAAATTTTT TAGGATAACT TGGTGCCTAC 1440

CTGAAAAATG TATTGTGTTT TAGACTCTTG ATTTCAAAAG GTTCCACAGA ACTAGTCTGC 1500

GCTTACCTTA CCCATGTTTA TATATAGCTG TCCTACAGGG AGCTTTTATT TAGAAAATGT 1560

CTGCATAATG TTAGATTCTT CTCCTGTCTA CATTATGCAC TACATAATTG GACTTCATTA 1620

TGCTTTTGAA ATGCTTATCT GCCTGTCACA TAAGTTAAAC TATTTAATTT GTTTTGAATG 1680

TTTTGGATTG CTACACAATA CAATATTCTA AATTTAGGCA TGAGGGTTTT TTTGTTTTAT 1740

TTTTACTTTT TTTTTGTCAT TGCACTATGG AACACAAATG AAATTCTCTT AATTTATAAG 1800

AAGATAGTAG GAGTTAAATT TTGAAAATGG TTGTGATGAG CCACGAAATT CAATCTTTAT 1860

AATATAGGTA CTGCTCTTTG AGACAAACAG TCCATTTTTA ATGACTTCTT ATTTTGTTGA 1920

AATTACTTTA ACTGCTAATC ACTGTGGTTG CCAAATATTT ACTTCAGAAG CAAAGATTTT 1980

CAAACAAGCA TACACGATGC AAAATACCAG TCTGGCTTCT AGTCTATTTA CTGTTTTGTT 2040

TCACTCAGAT TAGCTCAGTT TTCTCATCAA AGCAGAATGC TATCTTGCGT GTGTGTGTGT 2100

GTGTGTGTGT GTGTGTGTGT GTATGTGTGT ATATATATAT ATATATATAT ATATATATTT 2160

_TTTTTTTTTT TTTTTTTTAA ATTACAAAAG CCATGAGCTG CTTTTATGCT GAAAATGGTC 2220

ATTTCCCTGT TCACTTACTG ACATGTGAAG AAGGGTTTCT TGCTTTCTTA AACATTTCCG 2280

TAAGGCAGGC TAGAAATGTA ATACTTCAAA TGTTTGATGA TTATGGTCTT TTGATAGGAA 2340

TAGATTCTGC TTGGGATATA TATCCAGGCA CTCTCTAAGG TCTAGGGTTG ATATTAACAA 2400

AGGAATGTAC TTAGAATAGC AGTACATTTT ATGCAAATAT GGAAATTATT TTAAGAAACA 2460

ATGACATATC AAAACTGCTT TTTACATGAT TTTGAAATAG ACTAGAAAGC TTTCCCTATA 2520

GACATATTAA TATTCCAATC ATAACTTTAA TTCAAGAATG CAGTTTTACC AAAAGAAAAA 2580

TTTGAAAATT TCTATTCAGG CTACTGGAAT TGGTTATTAA AAGAAAAAGG AAAAAGAAGA 2640

ATCTTGCTGC TTTCAGTATT TCCTGATTTT TTTGTAAATA TAAAGAGGAA CTTCAATTAT 2700

GAAAAATTTT TAAAAGATAT ATATATCTAT ATATCTATAT ATATGTACTG TTTTGTTTCC 2760

TGTCTTGAAG ATTTTGAGTT ATGGTTATTG GTTTCAGATT GATTAATTCA CATATGCTGT 2820

GTTTTCTTTA AAAGTCATAT GGGTTCGTGG CCTAATGCCT TGGATTTTAC ATATTTTTCT 2880

TTTTAAATGC AAAACCTTTT CAACAAAATA GTGTTTGTCA TCAGGTTGGT ACTAAACATT 2940

TATAATTACT GTGTAATTAT AAACAAAAAT ACATAAAGCT TTGAATATAA TTATGTAGCA 3000

TAAAAGTTAA GGTTGTTCAC TATGATGGCA TCTTAGAATT AAACAAAACT TTTACTAGGG 3060

CTGAAAAGAG AAGACTGATT TAATGTGGTG TGATTATTCT GAAGATAAAT GTCTGGCTAC 3120

AGGGAATATT TTGTACTAAA AAATGATTAC ACATATGGCT GTGTGTGTTT GAGTCTGTGT 3180

CTGTGAGAGA GCCAGAGAGA GTGAGAGAGA TTGACAGAGA AAGGGAGAGA CACACACACG 3240

CCCCTTGAAT TGCTTTAACT CCTAAGTGTT TCAGTCCTCA TTCCGGTAAA CTCCCCATGC 3300

TGATTCTTTG TTTTAAACTG AACCATAGGT ACAGTTTCCT TTTTGCCAAA TGTCAAAACA 3360

GGTACAAATT TTAAAATGTA ATGCTTTTTA AATAGAAAAA TGTATAAAAT TAGAAGTGCC 3420

CACATATAAA AAATACTTGA GATGAAGATT ATCTTTAGTG AATATCATCT GCATATCTCT 3480

GTAAGTTCAA TTGTGTTTCT TACAGTCCCT GTCATATTAC CAACAGAGGC AATAAAAGCT 3540 GCAGTGAAAT TG

Seq ID NO: 164 Protein sequence: Protein Accession ft: AAG00606

1 11 21 31 41 51

I I I I 1 I

MNKLKSSQKD KVRQFMIFTQ SSEKTAVSCL SQNDWKLDVA TDNFFQNPEL YIRESVKGSL 60

DRKKLEQLYN RYKDPQDENK IGIDGIQQFC DDLALDPASI SVLIIAWKFR AATQCEFSKQ 120

EFMDGMTELG CDSIEQLKAQ IPKMEQELKE PGRFKDFYQF TFNFAKNPGQ KGLDLEMAIA 180

YWNLVLNGRF KFLDLWNKFL LEHHKRSIPK DTWNLLLDFS TMIADDMSNY DEEGAWPVLI 240 DDFVEFARPQ IAGTKSTTV Seq ID NO: 165 DNA sequence Nucleic Acid Accession ft: AF256215 Coding sequence: 220-2028

11 21 31 41 51

I I I I

CTCCAGTCCG CATGCTCAGT AGCTGCTGCC GGCCGGGCTG C 1GGGGCGGCG TCCGCTGCGC 60 GCCTACGGGC TGCGGTGGCG GCCGCCGCGG CACCCGGCAG GGCCCGCCAG TCCCCGCTTC 120 CCTGCTCCAG AGCCGCCGCC TGGGCCGGGG CAGGGCGGGC CCGGGGCTCC TCCATGCTGC 180 CAGCCGCCGG GCTGCGGAGC CGACCAAGTG GCTCCTGCGA TGGCGGCGGA AGAGGAGGCT 240 GCGGCGGGAG GTAAAGTGTT GAGAGAGGAG AACCAGTGCA TTGCTCCTGT GGTTTCCAGC 300 CGCGTGAGTC CAGGGACAAG ACCAACAGCT ATGGGGTCTT TCAGCTCACA CATGACAGAG 360 TTTCCACGAA AACGCAAAGG AAGTGATTCA GACCCATCCC AAGTGGAAGA TGGTGAACAC 420 CAAGTTAAAA TGAAGGCCTT CAGAGAAGCT CATAGCCAAA CTGAAAAGCG GAGGAGAGAT 480 AAAATGAATA ACCTGATTGA AGAACTGTCT GCAATGATCC CTCAGTGCAA CCCCATGGCG 540 CGTAAACTGG ACAAACTTAC AGTTTTAAGA ATGGCTGTTC AACACTTGAG ATCTTTAAAA 600 GGCTTGACAA ATTCTTATGT GGGAAGTAAT TATAGACCAT CATTTCTTCA GGATAATGAG 660 CTCAGACATT TAATCCTTAA GACTGCAGAA GGCTTCTTAT TTGTGGTTGG ATGTGAAAGA 720 GGAAAAATTC TCTTCGTTTC TAAGTCAGTC TCCAAAATAC TTAATTATGA TCAGGCTAGT 780 TTGACTGGAC AAAGCTTATT TGACTTCTTA CATCCAAAAG ATGTTGCCAA AGTAAAGGAA 840 CAACTTTCTT CTTTTGATAT TTCACCAAGA GAAAAGCTAA TAGATGCCAA AACTGGTTTG 900 CAAGTTCACA GTAATCTCCA CGCTGGAAGG ACACGTGTGT ATTCTGGCTC AAGACGATCT 960 TTTTTCTGTC GGATAAAGAG TTGTAAAATC TCTGTCAAAG AAGAGCATGG ATGCTTACCC 1020 AACTCAAAGA AGAAAGAGCA CAGAAAATTC TATACTATCC ATTGCACTGG TTACTTGAGA 1080 AGCTGGCCTC CAAATATTGT TGGAATGGAA GAAGAAAGGA ACAGTAAGAA AGACAACAGT 1140 AATTTTACCT GCCTTGTGGC CATTGGAAGA TTACAGCCAT ATATTGTTCC ACAGAACAGT 1200 GGAGAGATTA ATGTGAAACC AACTGAATTT ATAACCCGGT TTGCAGTGAA TGGAAAATTT 1260 GTCTATGTAG ATCAAAGGGC AACAGCGATT TTAGGATATC TGCCTCAGGA ACTTTTGGGA 1320 ACTTCTTGTT ATGAATATTT TCATCAAGAT GACCACAATA ATTTGACTGA CAAGCACAAA 1380 GCAGTTCTAC AGAGTAAGGA GAAAATACTT ACAGATTCCT ACAAATTCAG AGCAAAAGAT 1440 GGCTCTTTTG TAACTTTAAA AAGCCAATGG TTTAGTTTCA CAAATCCTTG GACAAAAGAA 1500 CTGGAATATA TTGTATCTGT CAACACTTTA GTTTTGGGAC ATAGTGAGCC TGGAGAAGCA 1560 TCATTTTTAC CTTGTAGCTC TCAATCATCA GAAGAATCCT CTAGACAGTC CTGTATGAGT 1620 GTACCTGGAA TGTCTACTGG AACAGTACTT GGTGCTGGTA GTATTGGAAC AGATATTGCA 1680 AATGAAATTC TGGATTTACA GAGGTTACAG TCTTCTTCAT ACCTTGATGA TTCGAGTCCA 1740 ACAGGTTTAA TGAAAGATAC TCATACTGTA AACTGCAGGA GTATGTCAAA TAAGGAGTTG 1800 TTTCCACCAA GTCCTTCTGA AATGGGGGAG CTAGAGGCTA CCAGGCAAAA CCAGAGTACT 1860 GTTGCTGTCC ACAGCCATGA GCCACTCCTC AGTGATGGTG CACAGTTGGA TTTCGATGCC 1920 CTATGTGACA ATGATGACAC AGCCATGGCT GCATTTATGA ATTACTTAGA AGCAGAGGGG 1980 GGCCTGGGAG ACCCTGGGGA CTTCAGTGAC ATCCAGTGGA CCCTCTAGCC TTTGATTTTT 2040 AACTCCAAAA ATGAGAAACA TTTTAAAGCA TTATTTACGA AAAAACTGTC TCAACTATTC 2100 TTAAGTACTG TATTGATATT GTTTGTATCT TTTATTAATG TTCTACCACT TTTTATAGAT 2160 TTGCATCTTC CTGTCACAGG GATGTGGGGA AATACGTTTT CCTCCCAAGA GAACCAAGTT 2220 TATTATAGAC TCCTTTATTC AGTGAAATGG CTTATAATCC ACTAGTTGCC ATATTTTTGC 2280 TAAAATATTT CTAACCAAGA ATACTACTTA CATATTGTTT TGGCTTTGTT TTATTTTTGA 2340 TGCAGTTTTT TTTAGTTGAG GTAATGTAAT ATATTGATGT TTTCCTTTGT GTCTAAGATT 2400 GATTTATAAT AGTAGGTTTG TATAATTTGG AACATTTTCC ATGCCTTGCG AATTTCCTTA 2460 ATTGAGGATA GGGCTTACAC ACTTTAAGAA AACAGTGAGT ACTTGAACAT TTAAAGGGAC 2520 AGTGCAATTT ATAGTCATAA TCACATTGAA TACTGTATTT GATCTTTGGA GACTTAGGCA 2580 AGCACAGAGC TGGGATATTT ATGCTCAGTT GAGCACTTTA AGATGAATTT TAAGTGAGAT 2640 ^• GATTTCTTGC TTAAAACTCA GAAAGTCAAA AGAGTTTCAG CTTTCCTTAC AGAAAAGGAA 2700 GGATCTTGGG CCCTAGATCT TGGGGATTAA CCTCTGCATA TAAGATTTAC TCTTAATAGG 2760 CCAGACGTGG TGCTCACGCC TGTAATCCCA GTACTTTGGG AGGCTGAGAC GGGCAGATCA 2820 CTTGAGGTCA GGAGTTCAAG ACCAGCCTGG CCAATATGGT GAAACCCCGT TTCTACTAAA 2880 AATACAAAAA AAATTACCCA GGCACTCACT CTTGAGGTAA CTAACCAACT CCCACGATAA 2940 TGACAGTCCA TTCATGAGCG CAAAGGCCTC ATGACCTAAT GGCACACACC TGTAATCCCA 3000 ACTGCTTGGG AGGCTGAGGC GAGAGGATTG CTTGAACCTG GGAGGCAGAG GTTGCAGTGA 3060 GCCGAGATCG CACCACTGCA CTCCAGTCTG GGCAACAGAG TGAGACTTCA TCTCAAAAAA 3120 AGTAAAAAAA AAGATTTAAT ATAATCACTG AAGATCTCTA TTATAGATAG ATTAGGTTTT 3180 TGACATTGGA AACATACTTA GGGATAGATT TGTCCTAAAG GAAAAAAGTA GGCCCGGGCA 3240 GATTAAATGT CTTGTGTAAA GTCACACATT AAATTCAGTC ACACATTAAA TTCATAGAGT 3300 TTTAAATGTT TAATGTATAT AAACCAGTTT CTTTATACAC ATTTGGGAAA ACATTGGTCT 3360 CACAGATTAA ATGATTAACT AACTGACCCA GGAACTAGTT GTAGCTTTCT AAGTAATTAG 3420 GCAATTACAG TTATTGCCTG TAACCAAAGG TAATAAAACA AAATGACAAG TACATGTTTA 3480 AAATTATGAG GCAATGAGAA ATAATTTAAA AACCAATTTT CTAGTTATAA TTTAAAATTT 3540 GGAGAGCATT TTTAACAGTA ATTAATCCAG AGGTGGCTCA AATTGAGTAT AAGAATTAAG 3600 ATTATTTAAA ATACTGCATG TCTACCTTCT CGGGGATCAT ACTTTATAAC ACTTTCTGCT 3660 TCAGTAGCTC TTCATAGCTT GCCAAGTATG CTCCCATATT TTCTCTCTCG TGCCTCGCAA 3720 ATGAAAGTCA GATAGGCTGG GAACTCATGG GGCAGCCCTC AGACTTCAAT GTGGGCTTCA 3780 AATCCAGTTT CCTGTTCTAT ATGGTGCTAC ATCTTTCCAG AAAATTTCCC TCAGAGCCCC 3840 TCGCCAAAAC AAAGCATTAT TTTGACCCTG CATGCTATTT CTTTAGCTGT AGGTGATAGA 3900 TTAGAACTTC TGTCAGACAT GTTAATGACA AACATACCAA CAGACAATAA CCAAAGCAAA 3960 TGTTTCCTTC AAGTGTGAAA TGTGCAGGGG CTCGTGGGCA AGGATGTATT GGCACACTGT 4020 CCTCTTGAAC TGATAGTGTC CCAGCAATGT TGGAGGTTGG CACCATTCCT GGTCCGACAC 4080 TTGAGGACCT GAGAGACATC AGGTTTAGAA TGAGCCAAAG AAATCCTACA AGATGGGGAG 4140 AATTGGTGTG CAGCAGCCTA AGTGTTATAG TTAAGTCTAA AGAAGTATGA AAGATCCCCT 4200 GTGTTCTCTA AATTGAGCAG AGGGGCCTGC CTACCAATAT CACTTTTTAG GGGACTGAAC 4260 CATTGCAGGT TAGACTTGGC TTCCAAAGAG TCTGCCTAAG CCAGGGGTGG CAGGGTAGGC 4320 CATCATAGCT GGATGGCCTC AAAAGCAGAT GGGGGCAGAC TTGCCCTCGT GATGCCAGGA 4380 TTTGAGAGGC AGAGTTTCTA GAGGGAGACC AGTGCTGCCT CTCACAGTGG CAGTTTTTTC 4440 TCTTTGCAAG AGGAGGGGCT GTTCAATTCC ATAGACCAGT GGGCAGATAG CCAGTTGAAT 4500 ACTCTGTGCA TGGTTTGATC CTTTATTAGT TCGCTCTAAT ATTTTTCTGT AGATCCTTTT 4560 GTCCTGGACT CAAAATCTAA TCCATGCATT GTATGATACC GTAGCTCTCC TAAGGTTTGT 4620 GTTTCCTTCA AAATGTTTTA GTTTTCTTCA ACTAAATTTG ATTTTTGCTG TTAGAAGTGA 4680 CATATTTTTA TGGTATACAC TATGTTCCTT TTTTCTACTG CGAGTCAATT TTTTGAATTT 4740 TCGTGAGAAA GAATATATCT ACAAATTGCA CGAAAGTATC ATAAAAACAG TACTCTAGAG 4800 CAGCGCTGTC CAATAGAAAT ATAATCTGAG CCACATGTAT AATTTTATTT TCTTCTAGCC 4860

ACATTAAAGA AGTAAAAAGA TACAAGTAGA ACTAATTTTA ATGTTTTAAT TCAGTATATC 4920

CAAAATATCA TTTGAACATG TAATTAATAT AAAATTATTA ATGTGATATT TTACATTCTT 4980

TTGGTAATAC TAGTCTTCAA AATCTGGTAT GTATCTTACA TTGATAGCAC ATCTCACTTT 5040

GTACTAGCCA CATTGCAAGT GCTCAGTAGC CACATGTGGC TAGTGGCTAC TGCACTGGAC 5100

AGCACAGTTC TAGGTTCCAC CCTAACACCC AAGTCCTGTG GATTAGAATC CCAGAATCAG 5160

AGCTGGAAGT AAACATAGAG ATCAAACCTC CTTTTAAAAA TGAGGACGCT GAGGCACAGA 5220

GTTTAAATGG CTTGCATGAG GTCATACAGC TAAATTCAGC CTCAACAGGG TCTTCTGATT 5280

CCAGGCACTC TTCCCACTCC ACTACATTAC TGTAGTGGTA ATTCTTAGGG TTAAAAAAAG 5340

TGTAGAGTAG GCCGGGCGCA GTGGCTCATG CCTGTAATCC CAGCACTTTG GGAGGCCGAA 5400

GTGGGCGGAT CACGAGGTCA GGAGATCGAG ACCATCCTGG CCAACATGGT GAAACCCCGT 5460

CTCTACTGAA AATACAAAGC AAAATTAGCC AGGTGTGGTG GCGGGCGCCT GTGGTCCCAG 5520

CTGCTCTGGA GGCTGAGGCA GAATGGCGTG AACCCAGGAG GCAGAGATGG CAGTGAGCCA 5580

AGATCGCGCC ACTGCACCCC AGCCTGGGCG ACAGAGCGAG ACTCCATCTC AAAAAAAAAA 5640

AAAAAAAAAA AAGAAAAGAA AAGAAAAGTC TAGAGAACAT TATATTAAGT GGTTATTATT 5700

GAAGTAGACC AAAGTTTATA CCATAAGGAT ATTTTTCCTT AAATACCATG TTTGAAGAAC 5760

AATTATTTAT TGATCCTTGA ATCTGTAAGA TCAAATAACA AGTCTCTATC CATGTTACCA 5820

AATTTAACCT TTTGAAAATA ATAAACTTTA AAATATCAGA TGTGTTATTA CAGGATGATA 5880

CTTGGAATCA AGTGAAATGA GTTATATGGT CATCACTAAA TTTAGAAATC TATTGTGAAA 5940

CAAAGACAAA CAGGAAAGTA CAGAATAGAG ACTTTTAGTA AATAAATGGA ATTTAAAAGA 6000

AAGTGTTTAT TTACAGTGTC ACGACAGAAA AGGATGTCTT TGTTGTCATA GTCTTTGAGG 6060

GATCTCCGTA AAATCTGGGG CACAGGTACA AGAAATAGCC AATATTTAGT TCCCAGACCA 6120

TGTTTAGTAG TGTCCAGTTT CAGATCATGC TGCCAAGAGG TATCTCCCCC TCAGGTGGGT 6180

CATCACTGAG CCCTGGAATT GGAGACTCAT ACTTGCCCAG CACAATGTTA CGGGCAGACA 6240

GGCCGACATC TATGATTAGC TAGAAGCCAT AAAGAAAAGC TGCTAAGTGG CCACTAGGTG 6300

CCACTTTTCT GTTTTTGTAA TGCTTTCATT AGCAGATCTT TTTTTTCCAA GCTCCATGGG 6360

GCCTATGAGA GGCATTTATG ATTTTTGTGC CTACAATAAG TCAGCCTGTC TGGTGTGAGT 6420

TGTTTTATGA GAAATGCTTT CCAAGGGAGG TCTAGGAAGA TCCTGACACA TAAGAACTTT 6480

GGCTTAGAGA GCTTTCCAGG TGTAGTGCCA ATAAAAACTG ACCTGGAAAG AAAACCTGCC 6540

CAGCACGGAA CATGCTTTCT GAACTCACTT GAGAGTGTAT GGTGTATGTC ACTTCTCATA 6600

TATTCTTGAG TTTAGATTTG TCTTTTATAC AATTTTTAGC TCTTTTCCAG TTCACTTGTG 6660

CTCGTCTGTA TATTGGTATT TTTAAATTTT TGTGGTAAAT AATGAAAAGA GTGAAATTAT 6720

ATTTTATAAT TACTCATTTG TAGTTTTTTT .TTTTAATTTA ATAAACTTCC TCCAAAAAGT 6780 GCTCCCTTAA AA

Seq ID NO: 166 Protein sequence: Protein Accession ft: AAG34652

11 21 31 41 51

MAAEEEAAAG GKVLREENQC IAPWSSRVS PGTRPTAMGS FSSHMTEFPR KRKGSDSDPS 60

QVEDGEHQVK MKAFREAHSQ TEKRRRDKMN NLIEELSAMI PQCNPMARKL DKLTVLRMAV 120

QHLRSLKGLT NSYVGSNYRP SFLQDNELRH LILKTAEGFL FWGCERGKI LFVSKSVSKI 180

LNYDQASLTG QSLFDFLHPK DVAKVKEQLS SFDISPREKL IDAKTGLQVH SNLHAGRTRV 240

YSGSRRSFPC RIKSCKISVK EEHGCLPNSK KKEHRKFYTI HCTGYLRSWP PNIVGMEEER 300

NSKKDNSNFT CLVAIGRLQP YIVPQNSGEI NVKPTEFITR FAVNGKFVYV DQRATAILGY 360

LPQELLGTSC YEYFHQDDHN NLTDKHKAVL QSKEKILTDS YKFRAKDGSF VTLKSQWFSF 420

TNPWTKELEY IVSVNTLVLG HSEPGEASFL PCSSQSSEES SRQSCMSVPG MSTGTVLGAG 480

SIGTDIANEI LDLQRLQSSS YLDDSSPTGL MKDTHTVNCR SMSNKELFPP SPSEMGELEA 540

TRQNQSTVAV HSHEPLLSDG AQLDFDALCD NDDTAMAAFM NYLEAEGGLG DPGDFSDIQW 600 TL

Seq ID NO: 167 DNA sequence Nucleic Acid Accession ft: NM_014400 Coding sequence: 86-1126

11 21 31 41 51

I I I

GGTTACTCAT CCTGGGCTCA GGTAAGAGGG CCCGAGCTCG GAGGCGGCAC ACCCAGGGGG 60 GACGCCAAGG GAGCAGGACG GAGCCATGGA CCCCGCCAGG AAAGCAGGTG CCCAGGCCAT 120 GATCTGGACT GCAGGCTGGC TGCTGCTGCT GCTGCTTCGC GGAGGAGCGC AGGCCCTGGA 180 GTGCTACAGC TGCGTGCAGA AAGCAGATGA CGGATGCTCC CCGAACAAGA TGAAGACAGT 240 GAAGTGCGCG CCGGGCGTGG ACGTCTGCAC CGAGGCCGTG GGGGCGGTGG AGACCATCCA 300 CGGACAATTC TCGCTGGCAG TGCSGGGTTG CGGTTCGGGA CTCCCCGGCA AGAATGACCG 360 CGGCCTGGAT CTTCACGGGC TTCTGGCGTT CATCCAGCTG CAGCAATGCG CTCAGGATCG 420 CTGCAACGCC AAGCTCAACC TCACCTCGCG GGCGCTCGAC CCGGCAGGTA ATGAGAGTGC 480 ATACCCGCCC AACGGCGTGG AGTGCTACAG CTGTGTGGGC CTGAGCCGGG AGGCGTGCCA 540 GGGTACATCG CCGCCGGTCG TGAGCTGCTA CAACGCCAGC GATCATGTCT ACAAGGGCTG 600 CTTCGACGGC AACGTCACCT TGACGGCAGC TAATGTGACT GTGTCCTTGC CTGTCCGGGG 660 CTGTGTCCAG GATGAATTCT GCACTCGGGA TGGAGTAACA GGCCCAGGGT TCACGCTCAG 720 TGGCTCCTGT TGCCAGGGGT CCCGCTGTAA CTCTGACCTC CGCAACAAGA CCTACTTCTC 780 CCCTCGAATC CCACCCCTTG TCCGGCTGCC CCCTCCAGAG CCCACGACTG TGGCCTCAAC 840 CACATCTGTC ACCACTTCTA CCTCGGCCCC AGTGAGACCC ACATCCACCA CCAAACCCAT 900 GCCAGCGCCA ACCAGTCAGA CTCCGAGACA GGGAGTAGAA CACGAGGCCT CCCGGGATGA 960 GGAGCCCAGG TTGACTGGAG GCGCCGCTGG CCACCAGGAC CGCAGCAATT CAGGGCAGTA 1020 TCCTGCAAAA GGGGGGCCCC AGCAGCCCCA TAATAAAGGC TGTGTGGCTC CCACAGCTGG 1080 ATTGGCAGCC CTTCTGTTGG CCGTGGCTGC TGGTGTCCTA CTGTGAGCTT CTCCACCTGG 1140 AAATTTCCCT CTCACCTACT TCTCTGGCCC TGGGTACCCC TCTTCTCATC ACTTCCTGTT 1200 CCCACCACTG GACTGGGCTG GCCCAGCCCC TGTTTTTCCA ACATTCCCCA GTATCCCCAG 1260 CTTCTGCTGC GCTGGTTTGC GGCTTTGGGA AATAAAATAC CGTTGTATAT ATTCTGGCAG 1320 GGGTGTTCTA GCTTTTTGAG GACAGCTCCT GTATCCTTCT CATCCTTGTC TCTCCGCTTG 1380 TCCTCTTGTG ATGTTAGGAC AGAGTGAGAG AAGTCAGCTG TCACGGGGAA GGTGAGAGAG 1440 AGGATGCTAA GCTTCCTACT CACTTTCTCC TAGCCAGCCT GGACTTTGGA GCGTGGGGTG 1500 GGTGGGACAA TGGCTCCCCA CTCTAAGCAC TGCCTCCCCT ACTCCCCGCA TCTTTGGGGA 1560 ATCGGTTCCC CATATGTCTT CCTTACTAGA CTGTGAGCTC CTCGAGGGCA GGGACCGTGC 1620 CTTATGTCTG TGTGTGATCA GTTTCTGGCA CATAAATGCC TCAATAAAGA TTTAATTACT 1680 TTGTATAGTG AAAAAAAA

Seq ID NO: 168 Protein sequence: Protein Accession ft: NP_055215

1 11 21 31 41 51

I I I I I . I

MDPARKAGAQ AMIWTAGWLL LLLLRGGAQA LECYSCVQKA DDGCSPNKMK TVKCAPGVDV 60

CTEAVGAVET IHGQFSLAVX GCGSGLPGKN DRGLDLHGLL AFIQLQQCAQ DRCNAKLNLT 120

10 SRALDPAGNE SAYPPNGVEC YSCVGLSREA CQGTSPPWS CYNASDHVYK GCFDGNVTLT 180

AANVTVSLPV RGCVQDEFCT RDGVTGPGFT LSGSCCQGSR CNSDLRNKTY FSPRIPPLVR 240

LPPPEPTTVA STTSVTTSTS APVRPTSTTK PMPAPTSQTP RQGVEHEASR DEEPRLTGGA 300 AGHQDRSNSG QYPAKGGPQQ PHNKGCVAPT AGLAALLLAV AAGVLL

15 Seq ID NO : 169 DNA sequence Nucleic Acid Accession ft : NM_006875 Coding sequence : 186-1190

__ 1 11 21 . 31 41 51

20 i i i i i i

GAATTCGGCA CGAGCGCGCG GCGAATCTCA ACGCTGCGCC GTCTGCGGGC GCTTCCGGGC 60

CACCAGTTTC TCTGCTTTCC ACCCTGGCGC CCCCCAGCCC TGGCTCCCCA GCTGCGCTGC 120

CCCGGGCGTC CACGCCCTGC GGGCTTAGCG GGTTCAGTGG GCTCAATCTG CGCAGCGCCA 180

CCTCCATGTT GACCAAGCCT CTACAGGGGC CTCCCGCGCC CCCCGGGACC CCCACGCCGC 240

25 CGCCAGGAGG CAAGGATCGG GAAGCGTTCG AGGCCGAGTA TCGACTCGGC CCCCTCCTGG 300

GTAAGGGGGG CTTTGGCACC GTCTTCGCAG GACACCGCCT CACAGATCGA CTCCAGGTGG 360

CCATCAAAGT GATTCCCCGG AATCGTGTGC TGGGCTGGTC CCCCTTGTCA GACTCAGTCA 420

CATGCCCACT CGAAGTCGCA CTGCTATGGA AAGTGGGTGC AGGTGGTGGG CACCCTGGCG 480

TGATCCGCCT GCTTGACTGG TTTGAGACAC AGGAAGGCTT CATGCTGGTC CTCGAGCGGC 540

30 CTTTGCCCGC CCAGGATCTC TTTGACTATA TCACAGAGAA GGGCCCACTG GGTGAAGGCC 600

CAAGCCGCTG CTTCTTTGGC CAAGTAGTGG CAGCCATCCA GCACTGCCAT TCCCGTGGAG 660

TTGTCCATCG TGACATCAAG GATGAGAACA TCCTGATAGA CCTACGCCGT GGCTGTGCCA 720

AACTCATTGA TTTTGGTTCT GGTGCCCTGC TTCATGATGA ACCCTACACT GACTTTGATG 780

GGACAAGGGT GTACAGCCCC CCAGAGTGGA TCTCTCGACA CCAGTACCAT GCACTCCCGG 840

35 CCACTGTCTG GTCACTGGGC ATCCTCCTCT ATGACATGGT GTGTGGGGAC ATTCCCTTTG 900

AGAGGGACCA GGAGATTCTG GAAGCTGAGC TCCACTTCCC AGCCCATGTC TCCCCAGACT 960

GCTGTGCCCT AATCCGCCGG TGCCTGGCCC CCAAACCTTC TTCCCGACCC TCACTGGAAG 1020

AGATCCTGCT GGACCCCTGG ATGCAAACAC CAGCCGAGGA TGTTACCCCT CAACCCCTCC 1080

AAAGGAGGCC CTGCCCCTTT GGCCTGGTCC TTGCTACCCT AAGCCTGGCC TGGCCTGGCC 1140

40 TGGCCCCCAA TGGTCAGAAG AGCCATCCCA TGGCCATGTC ACAGGGATAG ATGGACATTT 1200

GTTGACTTGG TTTTACAGGT CATTACCAGT CATTAAAGTC CAGTATTACT AAGGTAAGGG 1260

ATTGAGGATC AGGGGTTAGA AGACATAAAC CAAGTTTGCC CAGTTCCCTT CCCAATCCTA 1320

CAAAGGAGCC TTCCTCCCAG AACCTGTGGT CCCTGATTTT GGAGGGGGAA CTTCTTGCTT 1380

CTCATTTTGC TAAGGAAGTT TATTTTGGTG AAGTTGTTCC CATTTTGAGC CCCGGGACTC 1440

45 TTATTTTGAT GATGTGTCAC CCCACATTGG CACCTCCTAC TACCACCACA CAAACTTAGT 1500

TCATATGCTT TTACTTGGGC AAGGGTGCTT TCCTTCCAAT ACCCCAGTAG CTTTTATTTT 1560

AGTAAAGGGA CCCTTTCCCC TAGCCTAGGG TCCCATATTG GGTCAAGCTG CTTACCTGCC 1620

TCAGCCCAGG ATTTTTTATT TTGGGGGAGG TAATGCCCTG TTGTTACCCC AAGGCTTCTT 1680

TTTTTTTTTT TTTTTTTTTG GGTGAGGGGA CCCTACTTTG TTATCCCAAG TGCTCTTATT 1740

50 CTGGTGAGAA GAACCTTAAT TCCATAATTT GGGAAGGAAT GGAAGATGGA CACCACCGGA 1800

CACCACCAGA CAATAGGATG GGATGGATGG TTTTTTGGGG GATGGGCTAG GGGAAATAAG 1860

GCTTGCTGTT TGTTTTCCTG GGGCGCTCCC TCCAATTTTG CAGATTTTTG CAACCTCCTC 1920

CTGAGCCGGG ATTGTCCAAT TACTAAAATG TAAATAATCA CGTATTGTGG GGAGGGGAGT 1980

TCCAAGTGTG CCCTCCTTTT TTTTCCTGCC TGGATTATTT AAAAAGCCAT GTGTGGAAAC 2040

55 CCACTATTTA ATAAAAGTAA TAGAATCAGA AAAAAAAAAA AAAAAAAA

Seq ID NO: 170 Protein sequence: Protein Accession ft: NP_006866

60

1 11 21 31 41 51

I I I I I I

MLTKPLQGPP APPGTPTPPP GGKDREAFEA EYRLGPLLGK GGFGTVFAGH RLTDRLQVAI 60

KVIPRNRVLG WSPLSDSVTC PLEVALLWKV GAGGGHPGVI RLLDWFETQE GFMLVLERPL 120

65 PAQDLPDYIT EKGPLGEGPS RCFFGQWAA IQHCHSRGW HRDIKDENIL IDLRRGCAKL 180

IDFGSGALLH DEPYTDFDGT RVYSPPEWIS RHQYHALPAT VWSLGILLYD MVCGDIPFER 240

DQEILEAELH FPAHVSPDCC ALIRRCLAPK PSSRPSLEEI LLDPWMQTPA EDVTPQPLQR 300 RPCPFGLVLA TLSLAWPGLA PNGQKSHPMA MSQG

70 Seq ID NO: 171 DNA sequence Nucleic Acid Accession ft: NM_003646 Coding sequence: 89..2875

__ 1 11 21 31 41 51

75 i i i i i i

GCGGCGCGGA GCGGGCGTGC TGAGCCCCGG CCGCCGGCCC GGCATGGGCG TCTCCCGCGG 60

GCCCTCCGCC GGCCGGGGCT AGGGCCGGAT GGAGCCGCGG GACGGTAGCC CCGAGGCCCG 120

GAGCAGCGAC TCCGAGTCGG CTTCCGCCTC GTCCAGCGGC TCCGAGCGCG ACGCCGGTCC 180

CGAGCCGGAC AAGGCGCCGC GGCGACTCAA CAAGCGGCGC TTCCCGGGGC TGCGGCTCTT 240

80 CGGGCACAGG AAAGCCATCA CCAAGTCGGG CCTCCAGCAC CTGGCCCCCC CTCCGCCCAC 300

CCCTGGGGCC CCGTGCAGCG AGTCAGAGCG GCAGATCCGG AGTACAGTGG ACTGGAGCGA 360

GTCAGCGACA TATGGGGAGC ACATCTGGTT CGAGACCAAC GTGTCCGGGG ACTTCTGCTA 420

CGTTGGGGAG CAGTACTGTG TAGCCAGGAT GCTGAAGTCA GTGTCTCGAA GAAAGTGCGC 480

AGCCTGCAAG ATTGTGGTGC ACACGCCCTG CATCGAGCAG CTGGAGAAGA TAAATTTCCG 540

85 CTGTAAGCCG TCCTTCCGTG AATCAGGCTC CAGGAATGTC CGCGAGCCAA CCTTTGTACG 600

GCACCACTGG GTACACAGAC GACGCCAGGA CGGCAAGTGT CGGCACTGTG GGAAGGGATT 660

CCAGCAGAAG TTCACCTTCC ACAGCAAGGA GATTGTGGCC ATCAGCTGCT CGTGGTGCAA 720 GCAGGCATAC CACAGCAAGG TGTCCTGCTT CATGCTGCAG CAGATCGAGG AGCCGTGCTC 780

GCTGGGGGTC CACGCAGCCG TGGTCATCCC GCCCACCTGG ATCCTCCGCG CCCGGAGGCC 840

CCAGAATACT CTGAAAGCAA GCAAGAAGAA GAAGAGGGCA TCCTTCAAGA GGAAGTCCAG 900

CAAGAAAGGG CCTGAGGAGG GCCGCTGGAG ACCCTTCATC ATCAGGCCCA CCCCCTCCCC 960

GCTCATGAAG CCCCTGCTGG TGTTTGTGAA CCCCAAGAGT GGGGGCAACC AGGGTGCAAA 1020

GATCATCCAG TCTTTCCTCT GGTATCTCAA TCCCGGACAA GTCTTCGACC TGAGCCAGGG 1080

AGGGCCCAAG GAGGCGCTGG AGATGTACCG CAAAGTGCAC AACCTGCGGA TCCTGGCGTG 1140

CGGGGGCGAC GGCACGGTGG GCTGGATCCT CTCCACCCTG GACCAGCTAC GCCTGAAGCC 1200

GCCACCCCCT GTTGCCATCC TGCCCCTGGG TACTGGCAAC GACTTGGCCC GAACCCTCAA 1260

CTGGGGTGGG GGCTACACAG ATGAGCCTGT GTCCAAGATC CTCTCCCACG TGGAGGAGGG 1320

GAACGTGGTA CAGCTGGACC GCTGGGACCT CCACGCTGAG CCCAACCCCG AGGCAGGGCC 1380

TGAGGACCGA GATGAAGGCG CCACCGACCG GTTGCCCCTG GATGTCTTCA ACAACTACTT 1440

CAGCCTGGGC TTTGACGCCC ACGTCACCCT GGAGTTCCAC GAGTCTCGAG AGGCCAACCC 1500

AGAGAAATTC AACAGCCGCT TTCGGAATAA GATGTTCTAC GCCGGGACAG CTTTCTCTGA 1560

CTTCCTGATG GGCAGCTCCA AGGACCTGGC CAAGCACATC CGAGTGGTGT GTGATGGAAT 1620

GGACTTGACT CCCAAGATCC AGGACCTGAA ACCCCAGTGT GTTGTTTTCC TGAACATCCC 1680

CAGGTACTGT GCGGGCACCA TGCCCTGGGG CCACCCTGGG GAGCACCACG ACTTTGAGCC 1740

CCAGCGGCAT GACGACGGCT ACCTCGAGGT CATTGGCTTC ACCATGACGT CGTTGGCCGC 1800

GCTGCAGGTG GGCGGACACG GCGAGCGGCT GACGCAGTGT CGCGAGGTGG TGCTCACCAC 1860

ATCCAAGGCC ATCCCGGTGC AGGTGGATGG CGAGCCCTGC AAGCTTGCAG CCTCACGCAT 1920

CCGCATCGCC CTGCGCAACC AGGCCACCAT GGTGCAGAAG GCCAAGCGGC GGAGCGCCGC 1980

CCCCCTGCAC AGCGACCAGC AGCCGGTGCC AGAGCAGTTG CGCATCCAGG TGAGTCGCGT 2040

CAGCATGCAC GACTATGAGG CCCTGCACTA CGACAAGGAG CAGCTCAAGG AGGCCTCTGT 2100

GCCGCTGGGC ACTGTGGTGG TCCCAGGAGA CAGTGACCTA GAGCTCTGCC GTGCCCACAT 2160 •

TGAGAGACTC CAGCAGGAGC CCGATGGTGC TGGAGCCAAG TCCCCGACAT GCCAGAAACT 2220

GTCCCCCAAG TGGTGCTTCC TGGACGCCAC CACTGCCAGC CGCTTCTACA GGATCGACCG 2280

AGCCCAGGAG CACCTCAACT ATGTGACTGA GATCGCACAG GATGAGATTT ATATCCTGGA 2340

CCCTGAGCTG CTGGGGGCAT CGGCCCGGCC TGACCTCCCA ACCCCCACTT CCCCTCTCCC 2400

CACCTCACCC TGCTCACCCA CGCCCCGGTC ACTGCAAGGG GATGCTGCAC CCCCTCAAGG 2460

TGAAGAGCTG ATTGAGGCTG CCAAGAGGAA CGACTTCTGT AAGCTCCAGG AGCTGCACCG 2520

AGCTGGGGGC GACCTCATGC ACCGAGACGA GCAGAGTCGC ACGCTCCTGC ACCACGCAGT 2580

CAGCACTGGC AGCAAGGATG TGGTCCGCTA CCTGCTGGAC CACGCCCCCC CAGAGATCCT 2640

TGATGCGGTG GAGGAAAACG GGGAGACCTG TTTGCACCAA GCAGCGGCCC TGGGCCAGCG 2700

CACCATCTGC CACTACATCG TGGAGGCCGG GGCCTCGCTC ATGAAGACAG ACCAGCAGGG 2760

CGACACTCCC CGGCAGCGGG CTGAGAAGGC TCAGGACACC GAGCTGGCCG CCTACCTGGA 2320

GAACCGGCAG CACTACCAGA TGATCCAGCG GGAGGACCAG GAGACGGCTG TGTAGCGGGC 2880

Seq ID NO: 172 Protein sequence: Protein Accession ft: NP 003637

1 11 21 31 41 51

I I I 1 I I

MEPRDGSPEA RSSDSESASA SSSGSERDAG PEPDKAPRRL NKRRFPGLRL FGHRKAITKS 60

GLQHLAPPPP TPGAPCSESE RQIRSTVDWS ESATYGEHIW FETNVSGDFC YVGEQYCVAR 120 MLKSVSRRKC AACKIWHTP CIEQLEKINF RCKPSFRESG SRNVREPTFV RHHWVHRRRQ 180

DGKCRHCGKG FQQKFTFHSK EIVAISCSWC KQAYHSKVSC FMLQQIEEPC SLGVHAAWI 240

PPTWILRARR PQNTLKASKK KKRASFKRKS SKKGPEEGRW RPFIIRPTPS PLMKPLLVFV 300

NPKSGGNQGA KIIQSFLWYL NPRQVFDLSQ GGPKEALEMY RKVHNLRILA CGGDGTVGWI 360

LSTLDQLRLK PPPPVAILPL GTGNDLARTL NWGGGYTDEP VSKILSHVEE GNWQLDRWD 420 LHAEPNPEAG PEDRDEGATD RLPLDVFNNY FSLGFDAHVT LEFHESREAN PEKFNSRFRN 480

KMFYAGTAPS DFLMGSSKDL AKHIRWCDG MDLTPKIQDL KPQCWFLNI PRYCAGTMPW 540

GHPGEHHDFE PQRHDDGYLE VIGFTMTSLA ALQVGGHGER LTQCREWLT TSKAIPVQVD 600

GEPCKLAASR IRIALRNQAT MVQKAKRRSA APLHSDQQPV PEQLRIQVSR VSMHDYEALH 660

YDKEQLKEAS VPLGTVWPG DSDLELCRAH IERLQQEPDG AGAKSPTCQK LSPKWCFLDA 720 TTASRFYRID RAQEHLNYVT EIAQDEIYIL DPELLGASAR PDLPTPTSPL PTSPCSPTPR 780

SLQGDAAPPQ GEELIEAAKR NDFCKLQELH RAGGDLMHRD EQSRTLLHHA VSTGSKDWR 840

YLLDHAPPEI LDAVEENGET CLHQAAALGQ RTICHYIVEA GASLMKTDQQ GDTPRQRAEK 900 AQDTELAAYL ENRQHYQMIQ REDQETAV Seq ID NO: 173 DNA sequence

Nucleic Acid Accession ft: AF232772 Coding sequence: 1-1662

1 11 21 31 41 51 i i i i i I

ATGCCGGTGC AGCTGACGAC AGCCCTGCGT GTGGTGGGCA CCAGCCTGTT TGCCCTGGCA 60

GTGCTGGGTG GCATCCTGGC AGCCTATGTG ACGGGCTACC AGTTCATCCA CACGGAAAAG 120

CACTACCTGT CCTTCGGCCT GTACGGCGCC ATCCTGGGCC TGCACCTGCT CATTCAGAGC 180

CTTTTTGCCT TCCTGGAGCA CCGGCGCATG CGACGTGCCG GCCAGGCCCT GAAGCTGCCC 240

TCCCCGCGGC GGGGCTCGGT GGCACTGTGC ATTGCCGCAT ACCAGGAGGA CCCTGACTAC 300

TTGCGCAAGT GCCTGCGCTC GGCCCAGCGC ATCTCCTTCC CTGACCTCAA GGTGGTCATG 360

GTGGTGGATG GCAACCGCCA GGAGGACGCC TACATGCTGG ACATCTTCCA CGAGGTGCTG ^' 420

GGCGGCACCG AGCAGGCCGG CTTCTTTGTG TGGCGCAGCA ACTTCCATGA GGCAGGCGAG 480

GGTGAGACGG AGGCCAGCCT GCAGGAGGGC ATGGACCGTG TGCGGGATGT GGTGCGGGCC 540

AGCACCTTCT CGTGCATCAT GCAGAAGTGG GGAGGCAAGC GCGAGGTCAT GTACACGGCC 600

TTCAAGGCCC TCGGCGATTC GGTGGACTAC ATCCAGGTGT GCGACTCTGA CACTGTGCTG 660

GATCCAGCCT GCACCATCGA GATGCTTCGA GTCCTGGAGG AGGATCCCCA AGTAGGGGGA 720

GTCGGGGGAG ATGTCCAGAT CCTCAACAAG TACGACTCAT GGATTTCCTT CCTGAGCAGC 780

GTGCGGTACT GGATGGCCTT CAACGTGGAG CGGGCCTGCC AGTCCTACTT TGGCTGTGTG 840

CAGTGTATTA GTGGGCCCTT GGGCATGTAC CGCAACAGCC TCCTCCAGCA GTTCCTGGAG 900

GACTGGTACC ATCAGAAGTT CCTAGGCAGC AAGTGCAGCT TCGGGGATGA CCGGCACCTC 960

ACCAACCGAG TCCTGAGCCT TGGCTACCGA ACTAAGTATA CCGCGCGCTC CAAGTGCCTC 1020

ACAGAGACCC CCACTAAGTA CCTCCGGTGG CTCAACCAGC AAACCCGCTG GAGCAAGTCT 1080

TACTTCCGGG AGTGGCTCTA CAACTCTCTG TGGTTCCATA AGCACCACCT CTGGATGACC 1140 TACGAGTCAG TGGTCACGGG TTTCTTCCCC TTCTTCCTCA TTGCCACGGT TATACAGCTT 1200

TTCTACCGGG GCCGCATCTG GAACATTCTC CTCTTCCTGC TGACGGTGCA GCTGGTGGGC 1260

ATTATCAAGG CCACCTACGC CTGCTTCCTT CGGGGCAATG CAGAGATGAT CTTCATGTCC 1320 CTCTACTCCC TCCTCTATAT GTCCAGCCTT CTGCCGGCCA AGATCTTTGC CATTGC ACC 1380

ATCAACAAAT CTGGCTGGGG CACCTCTGGC CGAAAAACCA TTGTGGTGAA CTTCATTGGC 1440

CTCATTCCTG TGTCCATCTG GGTGGCAGTT CTCCTGGAGG GGCTGGCCTA CACAGCTTAT 1500

TGCCAGGACC TGTTCAGTGA GACAGAGCTA GCCTTCCTTG TCTCTGGGGC TATACTGTAT 1560

GGCTGCTACT GGGTGGCCCT CCTCATGCTA TATCTGGCCA TCATCGCCCG GCGATGTGGG 1620

AAGAAGCCGG AGCAGTACAG CTTGGCTTTT GCTGAGGTGT GACATGGCCC CCAAGCAGAG 1680

CGGGTAAAGT GCAATGGGTA AGGGAGGGAA GGGGAATGGA AGAGAAAAGA CAGGGTGGGA 1740

GGGAGGAGGG AGTGCTGTGT TTTAGTCTCT TAATGGTCCA AAGGACAAAT CTAAAATGCA 1800

AAGAACGGTG ATGTAGTATG GCCTGACAGC TCTGTTTAGA GGAGGCAACA CTGATCCCCC 1860

10 AGATGCAGGG CTGCAGGGGA TTCTGTGTTT TCAGACTGCC TGTCTGCTTG CATCTGCACA 1920

TAGGCAGTAG CCTCCTCCTG GGCTCCAGAG GGCACTCAGA AGTTGTGCTA AACCAAGTTA 1980

AGTCCCATTC AGTGGCAACT TGTGATAGGT ACCTGAGTGA CGGCAACCTG CGGAAGGAGG 2040

TTCTCCCAGC CCATCTGAAC ACAACCAGAG GTGGCAGGAG AATTTCTACT GAGCGAGGTG 2100

GGCCGGTTAG TGTATGTCAC CCCCACCCCA CCCATAAGTA GTCATCAATG CAATAAGATT 2160

15 GCGCGTGAGA TACAAGGCCC AGAAGCCTGA TCTTTGGGCA TCAGAAAACA GGGTCCAGGA 2220

ATGGTGCTTT ATGTGAGATA CCCCACTCCA CATCAACATT CCAGGGATGA GCCAAACCAG 2280

CAGGGAGTTA GCACTGAACT GCTTTTAAAA GTGCACATTA AAAAGGAAAG TTTGCCAGGA 2340

GGAACAAAGA GATTGTGGTG GTGCTAAAGG AGGCCATAAG CTACACAGAG GCCTTGGGTG 2400

TTCCACCTGG AAACTGCTCA GACGTCTAGA TGGGTTCTTA GCTTGTCTGT GATCTCTGCT 2460

20 GGGGAGATAA AAAGATTAAG CCCCAACATG TTCAGAAAAG AAGTGAAGTC TTGGGTATTT 2520

TAACCTGTAT ACTCTTGAAT TCCTCTCAAA TTCAGCTCTG ATCTGAGGCT AAGACACACT 2580

CCCCACTTCA CTTTCTTCAA AGCCACATTT TTTGAGGTAT CACTGCAGTC ACCTCTTCTA 2640

CCCTCATCAT CATAGGTAAG GTTTTCAAGG TGGCAATTGG GGCGGAGCCC CGGCTTCTTA 2700

TAGAAGCTTC AGCAGGAGGC AAGCGTGTTC TCAGCACATA TGGGAACTAT GAGGAGCCTC 2760

25 TGATCAAATT GGCTACAATC TTGGAGCTGC TTGGACGGAT TCCTTGGCAG CCGGGTTAGC 2820

ATGTGTGACT TTCAGGCTAC TGTTCTTGAC AATCATCTCC AATGGAAAGC TTTTCAGTGT 2880

TCCCAAAGTG AACTCTCAAA TCCAAAATGG TTATCTTTGA GACCATCCAT TCTCCTCAGT 2940

GGCTTCTCCA GGGAATTCTT ACAGCCAAGT TGTGACAGTC ACTGCATTTG CCTGCTTCTT 3000

TCCAGAAACC AAACTAGGAG ATGAAACTGG TTCCTACATC CTAAGGTTCT TGCTTTCTCT 3060

30 CTCATGCCTC CTGAGGCTGT TTTTGGCTGT TTTCCCTCTG CTGCTTTTGG GGAATGAGGG 3120

GAAGCCATTT TCCAAGTGAC TTGCAATCCA GGCTGTTCTC AGCGTTTTGA GTTTAAAACC 3180

TGGGATCCTG ACTAAGCCTT TGACTTAAGG GTTGCTTGCT TGCCCTCCAA ATGTCCTTTC 3240

TCAAAGGGGC CAACTAACCC GTGCAGAACC AGCACTAAGG TGGACAGCAG ACAAGAGGGC 3300

AAGCCTCTAA TGTACCAAGT GCTTCCTACA AAGACGCAAG GTGTGCTCCG AACCACAGAT 3360

35 GGGCAAACCC TGGTGCTTTC CTTCATCTCC CACGAACTCA AGGGTTTTCC AAGTGTAGCT 3420

AACAGTTGCC ACATCACACA GACCTCCAGT TTCTGGTAAG ACTGCTGGTT GACATCAGAC 3480

CCAACCCATT GAAGGCTGGA AGGCAGCAGG CATTTGCTAA GGCAGCTGAT CCAGGCAATC 3540

GTTCTGCTGG CCAAGAAGTT AAACTATTTT GAGCATTAGA ATGGAGGAAA TCCGGTCAGC 3600

CAAGTGCAGA GTTCAGACTT CGCTAAGGGC TTGTTTTTCT TCAGCATTTA CTTGAAGATT 3660

40 AATGTAGGAT GACAGGCTCT CCTGGCTGTC CTACCATCAG CTCTGCCTTG CACTGTGGTC 3720

GTCAACTTTC CTCAAATCAA AAACAGGCAG GTACAGGTAG TGGGCTCACA ACGTTTGACC 3780

TCGACTGGTT TTTCTAAGTT ATTTTGTACA TTTTTCAGCA GCAAAACCAA ACTGGGTCTT 3840

CAGCTTTATC CCCGTTTCTT GCAAGGGAAG AGCCTTTATA CAATTGGACG CATTTTGGTT 3900

TTTCCTCATT GAGAATTCAA ATCCTCTTTT GTATTGTTTC TACAATAATT TGTAAACATA 3960

45 TTTATTTTTA CCTGCTTTTT TTTTTTTTTT TAATTTTCAG GTCAAGTTTT TTATACTGCA 4020 CTTATTTGTC AAAATAAAGA TTCTCACAT

Seq ID NO: 174 Protein sequence: Protein Accession ft: AAF36984

50

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I I I I I I

MPVQLTTALR WGTSLFALA VLGGILAAYV TGYQFIHTEK HYLSFGLYGA ILGLHLLIQS 60

LFAFLEHRRM RRAGQALKLP SPRRGSVALC IAAYQEDPDY LRKCLRSAQR ISFPDLKWM 120

55 WDGNRQEDA YMLDIFHEVL GGTEQAGFFV WRSNFHEAGE GETEASLQEG MDRVRDWRA 180

STFSCIMQKW GGKREVMYTA FKALGDSVDY IQVCDSDTVL DPACTIEMLR VLEEDPQVGG 240

VGGDVQILNK YDSWISFLSS VRYWMAFNVE RACQSYFGCV QCISGPLGMY RNSLLQQFLE 300

DWYHQKFLGS KCSFGDDRHL TNRVLSLGYR TKYTARSKCL TETPTKYLRW LNQQTRWSKS 360

YFREWLYNSL WFHKHHLWMT YESWTGFFP FFLIATVIQL FYRGRIWNIL LFLLTVQLVG 420

60 IIKATYACFL RGNAEMIFMS LYSLLYMSSL LPAKIFAIAT INKSGWGTSG RKTIWNFIG 480

LIPVSIWVAV LLEGLAYTAY CQDLFSETEL AFLVSGAILY GCYWVALLML YLAIIARRCG 540 KKPEQYSLAF AEV

, Seq ID NO: 175 DNA sequence 65 Nucleic Acid Accession ft: NM_000691 Coding sequence: 43..1404

__ 1 11 21 31 41 51

70 i i i i i i

CCAGGAGCCC CAGTTACCGG GAGAGGCTGT GTCAAAGGCG CCATGAGCAA GATCAGCGAG 60

GCCGTGAAGC GCGCCCGCGC CGCCTTCAGC TCGGGCAGGA CCCGTCCGCT GCAGTTCCGA 120

TTCCAGCAGC TGGAGGCGCT GCAGCGCCTG ATCCAGGAGC AGGAGCAGGA GCTGGTGGGC 180

GCGCTGGCCG CAGACCTGCA CAAGAATGAA TGGAACGCCT ACTATGAGGA GGTGGTGTAC 240

75 GTCCTAGAGG AGATCGAGTA CATGATCCAG AAGCTCCCTG AGTGGGCCGC GGATGAGCCC 300

GTGGAGAAGA CGCCCCAGAC TCAGCAGGAC GAGCTCTACA TCCACTCGGA GCCACTGGGC 360

GTGGTCCTCG TCATTGGCAC CTGGAACTAC CCCTTCAACC TCACCATCCA GCCCATGGTG 420

GGCGCCATCG CTGCAGGGAA CGCAGTGGTC CTCAAGCCCT CGGAGCTGAG TGAGAACATG 480

GCGAGCCTGC TGGCTACCAT CATCCCCCAG TACCTGGACA AGGATCTGTA CCCAGTAATC 540

80 AATGGGGGTG TCCCTGAGAC CACGGAGCTG CTCAAGGAGA GGTTCGACCA TATCCTGTAC 600

ACGGGCAGCA CGGGGGTGGG GAAGATCATC ATGACGGCTG CTGCCAAGCA CCTGACCCCT 660

GTCACGCTGG AGCTGGGAGG GAAGAGTCCC TGCTACGTGG ACAAGAACTG TGACCTGGAC 720

GTGGCCTGCC GACGCATCGC CTGGGGGAAA TTCATGAACA GTGGCCAGAC CTGCGTGGCC 780

CCAGACTACA TCCTCTGTGA CCCCTCGATC CAGAACCAAA TTGTGGAGAA GCTCAAGAAG 840

85 TCACTGAAAG AGTTCTACGG GGAAGATGCT AAGAAATCCC GGGACTATGG AAGAATCATT 900

AGTGCCCGGC ACTTCCAGAG GGTGATGGGC CTGATTGAGG GCCAGAAGGT GGCTTATGGG 960

GGCACCGGGG ATGCCGCCAC TCGCTACATA GCCCCCACCA TCCTCACGGA CGTGGACCCC 1020 CAGTCCCCGG TGATGCAAGA GGAGATCTTC GGGCCTGTGC TGCCCATCGT GTGCGTGCGC 1080

AGCCTGGAGG AGGCCATCCA GTTCATCAAC CAGCGTGAGA AGCCCCTGGC CCTCTACATG 1140 TTCTCCAGCA ACGACAAGGT GATTAAGAAG ATGATTGCAG AGACATCCAG TGGTGGGGTG 1200

GCGGCCAACG ATGTCATCGT CCACATCACC TTGCACTCTC TGCCCTTCGG GGGCGTGGGG 1260

AACAGCGGCA TGGGATCCTA CCATGGCAAG AAGAGCTTCG AGACTTTCTC TCACCGCCGC 1320

TCTTGCCTGG TGAGGCCTCT GATGAATGAT GAAGGCCTGA AGGTCAGATA CCCCCCGAGC 1380

CCGGCCAAGA TGACCCAGCA CTGAGGAGGG GTTGCTCCGC CTGGCCTGGC CATACTGTGT 1440

CCCATCGGAG TGCGGACCAC CCTCACTGGC TCTCCTGGCC CTGGAGAATC GCTCCTGCAG 1500

CCCCAGCCCA GCCCCACTCC TCTGCTGACC TGCTGACCTG TGCACACCCC ACTCCCACAT 1560

GGGCCCAGGC CTCACCATTC CAAGTCTCCA CCCCTTTCTA GACCAATAAA GAGACAAATA 1620 CAATTTTCTA ACTCGG

Seq ID NO: 176 Protein sequence: Protein Accession ft: NP_000682

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MSKISEAVKR ARAAFSSGRT RPLQFRFQQL EALQRLIQEQ EQELVGALAA DLHKNEWNAY 60 YEEWYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI HSEPLGWLV IGTWNYPFNL 120 TIQPMVGAIA AGNAWLKPS ELSENMASLL ATIIPQYLDK DLYPVINGGV PETTELLKER 180 FDHILYTGST GVGKIIMTAA AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS 240 GQTCVAPDYI LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG 300 QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVL PIVCVRSLEE AIQFINQREK 360 PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL PFGGVGNSGM GSYHGKKSFE 420 TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM TQH

Seq ID NO: 177 DNA sequence

Nucleic Acid Accession ft: NM_001067.1

Coding sequence: 108-4703

1 11 21 31 41 51

I I I I I I

CTAACCGACG CGCGTCTGTG GAGAAGCGGC TTGGTCGGGG GTGGTCTCGT GGGGTCCTGC 60 CTGTTTAGTC GCTTTCAGGG TTCTTGAGCC CCTTCACGAC CGTCACCATG GAAGTGTCAC 120 CATTGCAGCC TGTAAATGAA AATATGCAAG TCAACAAAAT AAAGAAAAAT GAAGATGCTA 180 AGAAAAGACT GTCTGTTGAA AGAATCTATC AAAAGAAAAC ACAATTGGAA CATATTTTGC 240 TCCGCCCAGA CACCTACATT GGTTCTGTGG AATTAGTGAC CCAGCAAATG TGGGTTTACG 300 ATGAAGATGT TGGCATTAAC TATAGGGAAG TCACTTTTGT TCCTGGTTTG TACAAAATCT 360 TTGATGAGAT TCTAGTTAAT GCTGCGGACA ACAAACAAAG GGACCCAAAA ATGTCTTGTA 420 TTAGAGTCAC AATTGATCCG GAAAACAATT TAATTAGTAT ATGGAATAAT GGAAAAGGTA 480 TTCCTGTTGT TGAACACAAA GTTGAAAAGA TGTATGTCCC AGCTCTCATA TTTGGACAGC 540 TCCTAACTTC TAGTAACTAT GATGATGATG AAAAGAAAGT GACAGGTGGT CGAAATGGCT 600 ATGGAGCCAA ATTGTGTAAC ATATTCAGTA CCAAATTTAC TGTGGAAACA GCCAGTAGAG 660 AATACAAGAA AATGTTCAAA CAGACATGGA TGGATAATAT GGGAAGAGCT GGTGAGATGG 720 AACTCAAGCC CTTCAATGGA GAAGATTATA CATGTATCAC CTTTCAGCCT GATTTGTCTA 780 AGTTTAAAAT GCAAAGCCTG GACAAAGATA TTGTTGCACT AATGGTCAGA AGAGCATATG 840 ATATTGCTGG ATCCACCAAA GATGTCAAAG TCTTTCTTAA TGGAAATAAA CTGCCAGTAA 900 AAGGATTTCG TAGTTATGTG GACATGTATT TGAAGGACAA GTTGGATGAA ACTGGTAACT 960

CCTTGAAAGT AATACATGAA CAAGTAAACC ACAGGTGGGA AGTGTGTTTA ACTATGAGTG 1020

AAAAAGGCTT TCAGCAAATT AGCTTTGTCA ACAGCATTGC TACATCCAAG GGTGGCAGAC 1080

ATGTTGATTA TGTAGCTGAT CAGATTGTGA CTAAACTTGT TGATGTTGTG AAGAAGAAGA 1140

ACAAGGGTGG TGTTGCAGTA AAAGCACATC AGGTGAAAAA TCACATGTGG ATTTTTGTAA 1200

ATGCCTTAAT TGAAAACCCA ACCTTTGACT CTCAGACAAA AGAAAACATG ACTTTACAAC 1260

CCAAGAGCTT TGGATCAACA TGCCAATTGA GTGAAAAATT TATCAAAGCT GCCATTGGCT 1320

GTGGTATTGT AGAAAGCATA CTAAACTGGG TGAAGTTTAA GGCCCAAGTC CAGTTAAACA 1380

AGAAGTGTTC AGCTGTAAAA CATAATAGAA TCAAGGGAAT TCCCAAACTC GATGATGCCA 1440

ATGATGCAGG GGGCCGAAAC TCCACTGAGT GTACGCTTAT CCTGACTGAG GGAGATTCAG 1500

CCAAAACTTT GGCTGTTTCA GGCCTTGGTG TGGTTGGGAG AGACAAATAT GGGGTTTTCC 1560

CTCTTAGAGG AAAAATACTC AATGTTCGAG AAGCTTCTCA TAAGCAGATC ATGGAAAATG 1620

CTGAGATTAA CAATATCATC AAGATTGTGG GTCTTCAGTA CAAGAAAAAC TATGAAGATG 1680

AAGATTCATT GAAGACGCTT CGTTATGGGA AGATAATGAT TATGACAGAT CAGGACCAAG 1740

ATGGTTCCCA CATCAAAGGC TTGCTGATTA ATTTTATCCA TCACAACTGG CCCTCTCTTC 1800

TGCGACATCG TTTTCTGGAG GAATTTATCA CTCCCATTGT AAAGGTATCT AAAAACAAGC 1860

AAGAAATGGC ATTTTACAGC CTTCCTGAAT TTGAAGAGTG GAAGAGTTCT ACTCCAAATC 1920

ATAAAAAATG GAAAGTCAAA TATTACAAAG GTTTGGGCAC CAGCACATCA AAGGAAGCTA 1980

AAGAATACTT TGCAGATATG AAAAGACATC GTATCCAGTT CAAATATTCT GGTCCTGAAG 2040

ATGATGCTGC TATCAGCCTG GCCTTTAGCA AAAAACAGAT AGATGATCGA AAGGAATGGT 2100

TAACTAATTT CATGGAGGAT AGAAGACAAC GAAAGTTACT TGGGCTTCCT GAGGATTACT 2160

TGTATGGACA AACTACCACA TATCTGACAT ATAATGACTT CATCAACAAG GAACTTATCT 2220

TGTTCTCAAA TTCTGATAAC GAGAGATCTA TCCCTTCTAT GGTGGATGGT TTGAAACCAG 2280

GTCAGAGAAA GGTTTTGTTT ACTTGCTTCA AACGGAATGA CAAGCGAGAA GTAAAGGTTG 2340

CCCAATTAGC TGGATCAGTG GCTGAAATGT CTTCTTATCA TCATGGTGAG ATGTCACTAA 2400

TGATGACCAT TATCAATTTG GCTCAGAATT TTGTGGGTAG CAATAATCTA AACCTCTTGC 2460

AGCCCATTGG TCAGTTTGGT ACCAGGCTAC ATGGTGGCAA GGATTCTGCT AGTCCACGAT 2520

ACATCTTTAC AATGCTCAGC TCTTTGGCTC GATTGTTATT TCCACCAAAA GATGATCACA 2580

CGTTGAAGTT TTTATATGAT GACAACCAGC GTGTTGAGCC TGAATGGTAC ATTCCTATTA 2640

TTCCCATGGT GCTGATAAAT GGTGCTGAAG GAATCGGTAC TGGGTGGTCC TGCAAAATCC 2700

CCAACTTTG TGTGCGTGAA ATTGTAAATA ACATCAGGCG TTTGATGGAT GGAGAAGAAC 2760

CTTTGCCAAT GCTTCCAAGT TACAAGAACT TCAAGGGTAC TATTGAAGAA CTGGCTCCAA 2820

ATCAATATGT GATTAGTGGT GAAGTAGCTA TTCTTAATTC TACAACCATT GAAATCTCAG 2880

AGCTTCCCGT CAGAACATGG ACCCAGACAT ACAAAGAACA AGTTCTAGAA CCCATGTTGA 2940

ATGGCACCGA GAAGACACCT CCTCTCATAA CAGACTATAG GGAATACCAT ACAGATACCA 3000

CTGTGAAATT TGTTGTGAAG ATGACTGAAG AAAAACTGGC AGAGGCAGAG AGAGTTGGAC 3060

TACACAAAGT CTTCAAACTC CAAACTAGTC TCACATGCAA CTCTATGGTG CTTTTTGACC 3120

ACGTAGGCTG TTTAAAGAAA TATGACACGG TGTTGGATAT TCTAAGAGAC TTTTTTGAAC 3180

TCAGACTTAA ATATTATGGA TTAAGAAAAG AATGGCTCCT AGGAATGCTT GGTGCTGAAT 3240

CTGCTAAACT GAATAATCAG GCTCGCTTTA TCTTAGAGAA AATAGATGGC AAAATAATCA 3300 TTGAAAATAA GCCTAAGAAA GAATTAATTA AAGTTCTGAT TCAGAGGGGA TATGATTCGG 3360

ATCCTGTGAA GGCCTGGAAA GAAGCCCAGC AAAAGGTTCC AGATGAAGAA GAAAATGAAG 3420

AGAGTGACAA CGAAAAGGAA ACTGAAAAGA GTGACTCCGT AACAGATTCT GGACCAACCT 3480

TCAACTATCT TCTTGATATG CCCCTTTGGT ATTTAACCAA GGAAAAGAAA GATGAACTCT 3540

5 GCAGGCTAAG AAATGAAAAA GAACAAGAGC TGGACACATT AAAAAGAAAG AGTCCATCAG 3600

ATTTGTGGAA AGAAGACTTG GCTACATTTA TTGAAGAATT GGAGGCTGTT GAAGCCAAGG 3660

AAAAACAAGA TGAACAAGTC GGACTTCCTG GGAAAGGGGG GAAGGCCAAG GGGAAAAAAA 3720

CACAAATGGC TGAAGTTTTG CCTTCTCCGC GTGGTCAAAG AGTCATTCCA CGAATAACCA 3780

TAGAAATGAA AGCAGAGGCA GAAAAGAAAA ATAAAAAGAA AATTAAGAAT GAAAATACTG 3840

10 AAGGAAGCCC TCAAGAAGAT GGTGTGGAAC TAGAAGGCCT AAAACAAAGA TTAGAAAAGA 3900

AACAGAAAAG AGAACCAGGT ACAAAGACAA AGAAACAAAC TACATTGGCA TTTAAGCCAA 3960

TCAAAAAAGG AAAGAAGAGA AATCCCTGGC CTGATTCAGA ATCAGATAGG AGCAGTGACG 4020

AAAGTAATTT TGATGTCCCT CCACGAGAAA CAGAGCCACG GAGAGCAGCA ACAAAAACAA 4080

AATTCACAAT GGATTTGGAT TCAGATGAAG ATTTCTCAGA TTTTGATGAA AAAACTGATG 4140

15 ATGAAGATTT TGTCCCATCA GATGCTAGTC CACCTAAGAC CAAAACTTCC CCAAAACTTA 4200

GTAACAAAGA ACTGAAACCA CAGAAAAGTG TCGTGTCAGA CCTTGAAGCT GATGATGTTA 4260

AGGGCAGTGT ACCACTGTCT TCAAGCCCTC CTGCTACACA TTTCCCAGAT GAAACTGAAA 4320

TTACAAACCC AGTTCCTAAA AAGAATGTGA CAGTGAAGAA GACAGCAGCA AAAAGTCAGT 4380

CTTCCACCTC CACTACCGGT GCCAAAAAAA GGGCTGCCCC AAAAGGAACT AAAAGGGATC 4440

20 CAGCTTTGAA TTCTGGTGTC TCTCAAAAGC CTGATCCTGC CAAAACCAAG AATCGCCGCA 4500

AAAGGAAGCC ATCCACTTCT GATGATTCTG ACTCTAATTT TGAGAAAATT GTTTCGAAAG 4560

CAGTCACAAG CAAGAAATCC AAGGGGGAGA GTGATGACTT CCATATGGAC TTTGACTCAG 4620

CTGTGGCTCC TCGGGCAAAA TCTGTACGGG CAAAGAAACC TATAAAGTAC CTGGAAGAGT 4680

CAGATGAAGA TGATCTGTTT TAAAATGTGA GGCGATTATT TTAAGTAATT ATCTTACCAA 4740

25 GCCCAAGACT GGTTTTAAAG TTACCTGAAG CTCTTAACTT CCTCCCCTCT GAATTTAGTT 4800

TGGGGAAGGT GTTTTTAGTA CAAGACATCA AAGTGAAGTA AAGCCCAAGT GTTCTTTAGC 4860

TTTTTATAAT ACTGTCTAAA TAGTGACCAT CTCATGGGCA TTGTTTTCTT CTCTGCTTTG 4920

TCTGTGTTTT GAGTCTGCTT TCTTTTGTCT TTAAAACCTG ATTTTTAAGT TCTTCTGAAC 4980

TGTAGAAATA GCTATCTGAT CACTTCAGCG TAAAGCAGTG TGTTTATTAA CCATCCACTA 5040

30 AGCTAAAACT AGAGCAGTTT GATTTAAAAG TGTCACTCTT CCTCCTTTTC TACTTTCAGT 5100

AGATATGAGA TAGAGCATAA TTATCTGTTT TATCTTAGTT TTATACATAA TTTACCATCA 5160

GATAGAACTT TATGGTTCTA GTACAGATAC TCTACTACAC TCAGCCTCTT ATGTGCCAAG 5220

TTTTTCTTTA AGCAATGAGA AATTGCTCAT GTTCTTCATC TTCTCAAATC ATCAGAGGCC 5280

AAAGAAAAAC ACTTTGGCTG TGTCTATAAC TTGACACAGT CAATAGAATG AAGAAAATTA 5340

35 GAGTAGTTAT GTGATTATTT CAGCTCTTGA CCTGTCCCCT CTGGCTGCCT CTGAGTCTGA 5400

ATCTCCCAAA GAGAGAAACC AATTTCTAAG AGGACTGGAT TGCAGAAGAC TCGGGGACAA 5460

CATTTGATCC AAGATCTTAA ATGTTATATT GATAACCATG CTCAGCAATG AGCTATTAGA 5520

TTCATTTTGG GAAATCTCCA TAATTTCAAT TTGTAAACTT TGTTAAGACC TGTCTACATT 5580

GTTATATGTG TGTGACTTGA GTAATGTTAT CAACGTTTTT GTAAATATTT ACTATGTTTT 5640 40 TCTATTAGCT AAATTCCAAC AATTTTGTAC TTTAATAAAA TGTTCTAAAC ATTGC

Seq ID NO: 178 Protein sequence: Protein Accession ft: NP 001058.1

45 11 21 31 41 51

M IEVSPLQPVN EINMQVNKIKK NIEDAKKRLSV EIRIYQKKTQL EIHILLRPDTY IIGSVELVTQQ 60

MWVYDEDVGI NYREVTFVPG LYKIFDEILV NAADNKQRDP KMSCIRVTID PENNLISIWN 120

NGKGIPWEH KVEKMYVPAL IFGQLLTSSN YDDDEKKVTG GRNGYGAKLC NIFSTKFTVE 180

50 TASREYKKMF KQTWMDNMGR AGEMELKPFN GEDYTCITFQ PDLSKFKMQS LDKDIVALMV 240

RRAYDIAGST KDVKVFLNGN KLPVKGFRSY VDMYLKDKLD ETGNSLKVIH EQVNHRWEVC 300

LTMSEKGFQQ ISFVNSIATS KGGRHVDYVA DQIVTKLVDV VKKKNKGGVA VKAHQVKNHM 360

WIFVNALIEN PTFDSQTKEN MTLQPKSFGS TCQLSEKFIK AAIGCGIVES ILNWVKFKAQ 420

VQLNKKCSAV KHNRIKGIPK LDDANDAGGR NSTECTLILT EGDSAKTLAV SGLGWGRDK 480

55 YGVFPLRGKI LNVREASHKQ IMENAEINNI IKIVGLQYKK NYEDEDSLKT LRYGKIMIMT 540

DQDQDGSHIK GLLINPIHHN WPSLLRHRFL EEFITPIVKV SKNKQEMAFY SLPEFEEWKS 600

STPNHKKWKV KYYKGLGTST SKEAKEYFAD MKRHRIQFKY SGPEDDAAIS LAFSKKQIDD 660

RKEWLTNFME DRRQRKLLGL PEDYLYGQTT TYLTYNDFIN KELILFSNSD NERSIPSMVD 720

GLKPGQRKVL FTCFKRNDKR EVKVAQLAGS VAEMSSYHHG EMSLMMTIIN LAQNFVGSNN 780

60 LNLLQPIGQF GTRLHGGKDS ASPRYIFTML SSLARLLFPP KDDHTLKFLY DDNQRVEPEW 840

YIPIIPMVLI NGAEGIGTGW SCKIPNFDVR EIVNNIRRLM DGEEPLPMLP SYKNFKGTIE 900

ELAPNQYVIS GEVAILNSTT IEISELPVRT WTQTYKEQVL EPMLNGTEKT PPLITDYREY 960

HTDTTVKFW KMTEEKLAEA ERVGLHKVFK LQTSLTCNSM VLFDHVGCLK KYDTVLDILR 1020

DFFELRLKYY GLRKEWLLGM LGAESAKLNN QARFILEKID GKIIIENKPK KELIKVLIQR 1080

65 GYDSDPVKAW KEAQQKVPDE EENEESDNEK ETEKSDSVTD SGPTFNYLLD MPLWYLTKEK 1140

KDELCRLRNE KEQELDTLKR KSPSDLWKED LATFIEELEA VEAKEKQDEQ VGLPGKGGKA 1200

KGKKTQMAEV LPSPRGQRVI PRITIEMKAE AEKKNKKKIK NENTEGSPQE DGVELEGLKQ 1260

RLEKKQKREP GTKTKKQTTL AFKPIKKGKK RNPWPDSESD RSSDESNFDV PPRETEPRRA 1320

ATKTKFTMDL DSDEDFSDFD EKTDDEDFVP SDASPPKTKT SPKLSNKELK PQKSWSDLE 1380

70 ADDVKGSVPL SSSPPATHFP DETEITNPVP KKNVTVKKTA AKSQSSTSTT GAKKRAAPKG 1440

TKRDPALNSG VSQKPDPAKT KNRRKRKPST SDDSDSNFEK IVSKAVTSKK SKGESDDFHM 1500 DFDSAVAPRA KSVRAKKPIK YLEESDEDDL F

75 Seq ID NO: 179 DNA sequence

Nucleic Acid Accession ft: Eos sequence Coding sequence: 148-7095

__ 1 11 21 31 41 51

80 i i i i i i

CACACATACG CACGCACGAT CTCACTTCGA TCTATACACT GGAGGATTAA AACAAACAAA 60

CAAAAAAAAC ATTTCCTTCG CTCCCCCTCC CTCTCCACTC TGAGAAGCAG AGGAGCCGCA 120

CGGCGAGGGG CCGCAGACCG TCTGGAAATG CGAATCCTAA AGCGTTTCCT CGCTTGCATT 180

₀ _ CAGCTCCTCT GTGTTTGCCG CCTGGATTGG GCTAATGGAT ACTACAGACA ACAGAGAAAA 240

85 CTTGTTGAAG AGATTGGCTG GTCCTATACA GGAGCACTGA ATCAAAAAAA TTGGGGAAAG 300

AAATATCCAA CATGTAATAG CCCAAAACAA TCTCCTATCA ATATTGATGA AGATCTTACA 360

CAAGTAAATG TGAATCTTAA GAAACTTAAA TTTCAGGGTT GGGATAAAAC ATCATTGGAA 420 AACACATTCA TTCATAACAC TGGGAAAACA GTGGAAATTA ATCTCACTAA TGACTACCGT 480

GTCAGCGGAG GAGTTTCAGA AATGGTGTTT AAAGCAAGCA AGATAACTTT TCACTGGGGA 540

AAATGCAATA TGTCATCTGA TGGATCAGAG CATAGTTTAG AAGGACAAAA ATTTCCACTT 600

GAGATGCAAA TCTACTGCTT TGATGCGGAC CGATTTTCAA GTTTTGAGGA AGCAGTCAAA 660

GGAAAAGGGA AGTTAAGAGC TTTATCCATT TTGTTTGAGG TTGGGACAGA AGAAAATTTG 720

GATTTCAAAG CGATTATTGA TGGAGTCGAA AGTGTTAGTC GTTTTGGGAA GCAGGCTGCT 780

TTAGATCCAT TCATACTGTT GAACCTTCTG CCAAACTCAA CTGACAAGTA TTACATTTAC 840

AATGGCTCAT TGACATCTCC TCCCTGCACA GACACAGTTG ACTGGATTGT TTTTAAAGAT 900

ACAGTTAGCA TCTCTGAAAG CCAGTTGGCT GTTTTTTGTG AAGTTCTTAC AATGCAACAA 960

TCTGGTTATG TCATGCTGAT GGACTACTTA CAAAACAATT TTCGAGAGCA ACAGTACAAG 1020

TTCTCTAGAC AGGTGTTTTC CTCATACACT GGAAAGGAAG AGATTCATGA AGCAGTTTGT 1080

AGTTCAGAAC CAGAAAATGT TCAGGCTGAC CCAGAGAATT ATACCAGCCT TCTTGTTACA 1140

TGGGAAAGAC CTCGAGTCGT TTATGATACC ATGATTGAGA AGTTTGCAGT TTTGTACCAG 1200

CAGTTGGATG GAGAGGACCA AACCAAGCAT GAATTTTTGA CAGATGGCTA TCAAGACTTG 1260

GGTGCTATTC TCAATAATTT GCTACCCAAT ATGAGTTATG TTCTTCAGAT AGTAGCCATA 1320

TGCACTAATG GCTTATATGG AAAATACAGC GACCAACTGA TTGTCGACAT GCCTACTGAT 1380

AATCCTGAAC TTGATCTTTT CCCTGAATTA ATTGGAACTG AAGAAATAAT CAAGGAGGAG 1440

GAAGAGGGAA AAGACATTGA AGAAGGCGCT ATTGTGAATC CTGGTAGAGA CAGTGCTACA 1500

AACCAAATCA GGAAAAAGGA ACCCCAGATT TCTACCACAA CACACTACAA TCGCATAGGG 1560

ACGAAATACA ATGAAGCCAA GACTAACCGA TCCCCAACAA GAGGAAGTGA ATTCTCTGGA 1620

AAGGGTGATG TTCCCAATAC ATCTTTAAAT TCCACTTCCC AACCAGTCAC TAAATTAGCC 1680

ACAGAAAAAG ATATTTCCTT GACTTCTCAG ACTGTGACTG AACTGCCACC TCACACTGTG 1740

GAAGGTACTT CAGCCTCTTT AAATGATGGC TCTAAAACTG TTCTTAGATC TCCACATATG 1800

AACTTGTCGG GGACTGCAGA ATCCTTAAAT ACAGTTTCTA TAACAGAATA TGAGGAGGAG 1860

AGTTTATTGA CCAGTTTCAA GCTTGATACT GGAGCTGAAG ATTCTTCAGG CTCCAGTCCC 1920

GCAACTTCTG CTATCCCATT CATCTCTGAG AACATATCCC AAGGGTATAT ATTTTCCTCC 1980

GAAAACCCAG AGACAATAAC ATATGATGTC CTTATACCAG AATCTGCTAG AAATGCTTCC 2040

GAAGATTCAA CTTCATCAGG TTCAGAAGAA TCACTAAAGG ATCCTTCTAT GGAGGGAAAT 2100

GTGTGGTTTC CTAGCTCTAC AGACATAACA GCACAGCCCG ATGTTGGATC AGGCAGAGAG 2160

AGCTTTCTCC AGACTAATTA CACTGAGATA CGTGTTGATG AATCTGAGAA GACAACCAAG 2220

TCCTTTTCTG CAGGCCCAGT GATGTCACAG GGTCCCTCAG TTACAGATCT GGAAATGCCA 2280

CATTATTCTA CCTTTGCCTA CTTCCCAACT GAGGTAACAC CTCATGCTTT TACCCCATCC 2340

TCCAGACAAC AGGATTTGGT CTCCACGGTC AACGTGGTAT ACTCGCAGAC AACCCAACCG 2400

GTATACAATG GTGAGACACC TCTTCAACCT TCCTACAGTA GTGAAGTCTT TCCTCTAGTC 2460

ACCCCTTTGT TGCTTGACAA TCAGATCCTC AACACTACCC CTGCTGCTTC AAGTAGTGAT 2520

TCGGCCTTGC ATGCTACGCC TGTATTTCCC AGTGTCGATG TGTCATTTGA ATCCATCCTG 2580

TCTTCCTATG ATGGTGCACC TTTGCTTCCA TTTTCCTCTG CTTCCTTCAG TAGTGAATTG 2640

TTTCGCCATC TGCATACAGT TTCTCAAATC CTTCCACAAG TTACTTCAGC TACCGAGAGT 2700

GATAAGGTGC CCTTGCATGC TTCTCTGCCA GTGGCTGGGG GTGATTTGCT ATTAGAGCCC 2760

AGCCTTGCTC AGTATTCTGA TGTGCTGTCC ACTACTCATG CTGCTTCAGA GACGCTGGAA 2820

TTTGGTAGTG AATCTGGTGT TCTTTATAAA ACGCTTATGT TTTCTCAAGT TGAACCACCC 2880

AGCAGTGATG CCATGATGCA TGCACGTTCT TCAGGGCCTG AACCTTCTTA TGCCTTGTCT 2940

GATAATGAGG GCTCCCAACA CATCTTCACT GTTTCTTACA GTTCTGCAAT ACCTGTGCAT 3000

GATTCTGTGG GTGTAACTTA TCAGGGTTCC TTATTTAGCG GCCCTAGCCA TATACCAATA 3060

CCTAAGTCTT CGTTAATAAC CCCAACTGCA TCATTACTGC AGCCTACTCA TGCCCTCTCT 3120

GGTGATGGGG AATGGTCTGG AGCCTCTTCT GATAGTGAAT TTCTTTTACC TGACACAGAT 3180

GGGCTGACAG CCCTTAACAT TTCTTCACCT GTTTCTGTAG CTGAATTTAC ATATACAACA 3240

TCTGTGTTTG GTGATGATAA TAAGGCGCTT TCTAAAAGTG AAATAATATA TGGAAATGAG 3300

ACTGAACTGC AAATTCCTTC TTTCAATGAG ATGGTTTACC CTTCTGAAAG CACAGTCATG 3360

CCCAACATGT ATGATAATGT AAATAAGTTG AATGCGTCTT TACAAGAAAC CTCTGTTTCC 3420

ATTTCTAGCA CCAAGGGCAT GTTTCCAGGG TCCCTTGCTC ATACCACCAC TAAGGTTTTT 3480

GATCATGAGA TTAGTCAAGT TCCAGAAAAT AACTTTTCAG TTCAACCTAC ACATACTGTC 3540

TCTCAAGCAT CTGGTGACAC TTCGCTTAAA CCTGTGCTTA GTGCAAACTC AGAGCCAGCA 3600

TCCTCTGACC CTGCTTCTAG TGAAATGTTA TCTCCTTCAA CTCAGCTCTT ATTTTATGAG 3660

ACCTCAGCTT CTTTTAGTAC TGAAGTATTG CTACAACCTT CCTTTCAGGC TTCTGATGTT 3720

GACACCTTGC TTAAAACTGT TCTTCCAGCT GTGCCCAGTG ATCCAATATT GGTTGAAACC 3780

CCCAAAGTTG ATAAAATTAG TTCTACAATG TTGCATCTCA TTGTATCAAA TTCTGCTTCA 3840

AGTGAAAACA TGCTGCACTC TACATCTGTA CCAGTTTTTG ATGTGTCGCC TACTTCTCAT 3900

ATGCACTCTG CTTCACTTCA AGGTTTGACC ATTTCCTATG CAAGTGAGAA ATATGAACCA 3960

GTTTTGTTAA AAAGTGAAAG TTCCCACCAA GTGGTACCTT CTTTGTACAG TAATGATGAG 4020

TTGTTCCAAA CGGCCAATTT GGAGATTAAC CAGGCCCATC CCCCAAAAGG AAGGCATGTA 4080

TTTGCTACAC CTGTTTTATC AATTGATGAA CCATTAAATA CACTAATAAA TAAGCTTATA 4140

CATTCCGATG AAATTTTAAC CTCCACCAAA AGTTCTGTTA CTGGTAAGGT ATTTGCTGGT 4200

ATTCCAACAG TTGCTTCTGA TACATTTGTA TCTACTGATC ATTCTGTTCC TATAGGAAAT 4260

GGGCATGTTG CCATTACAGC TGTTTCTCCC CACAGAGATG GTTCTGTAAC CTCAACAAAG 4320

TTGCTGTTTC CTTCTAAGGC AACTTCTGAG CTGAGTCATA GTGCCAAATC TGATGCCGGT 4380

TTAGTGGGTG GTGGTGAAGA TGGTGACACT GATGATGATG GTGATGATGA TGATGATGAC 4440

AGAGGTAGTG ATGGCTTATC CATTCATAAG TGTATGTCAT GCTCATCCTA TAGAGAATCA 4500

CAGGAAAAGG TAATGAATGA TTCAGACACC CACGAAAACA GTCTTATGGA TCAGAATAAT 4560

CCAATCTCAT ACTCACTATC TGAGAATTCT GAAGAAGATA ATAGAGTCAC AAGTGTATCC 4620

TCAGACAGTC AAACTGGTAT GGACAGAAGT CCTGGTAAAT CACCATCAGC AAATGGGCTA 4680

TCCCAAAAGC ACAATGATGG AAAAGAGGAA AATGACATTC AGACTGGTAG TGCTCTGCTT 4740

CCTCTCAGCC CTGAATCTAA AGCATGGGCA GTTCTGACAA GTGATGAAGA AAGTGGATCA 4800

GGGCAAGGTA CCTCAGATAG CCTTAATGAG AATGAGACTT CCACAGATTT CAGTTTTGCA 4860

GACACTAATG AAAAAGATGC TGATGGGATC CTGGCAGCAG GTGACTCAGA AATAACTCCT 4920

GGATTCCCAC AGTCCCCAAC ATCATCTGTT ACTAGCGAGA ACTCAGAAGT GTTCCACGTT 4980

TCAGAGGCAG AGGCCAGTAA TAGTAGCCAT GAGTCTCGTA TTGGTCTAGC TGAGGGGTTG 5040

GAATCCGAGA AGAAGGCAGT TATACCCCTT GTGATCGTGT CAGCCCTGAC TTTTATCTGT 5100

CTAGTGGTTC TTGTGGGTAT TCTCATCTAC TGGAGGAAAT GCTTCCAGAC TGCACACTTT 5160

TACTTAGAGG ACAGTACATC CCCTAGAGTT ATATCCACAC CTCCAACACC TATCTTTCCA 5220

ATTTCAGATG ATGTCGGAGC AATTCCAATA AAGCACTTTC CAAAGCATGT TGCAGATTTA 5280

CATGCAAGTA GTGGGTTTAC TGAAGAATTT GAGACACTGA AAGAGTTTTA CCAGGAAGTG 5340

CAGAGCTGTA CTGTTGACTT AGGTATTACA GCAGACAGCT CCAACCACCC AGACAACAAG 5400

CACAAGAATC GATACATAAA TATCGTTGCC TATGATCATA GCAGGGTTAA GCTAGCACAG 5460

CTTGCTGAAA AGGATGGCAA ACTGACTGAT TATATCAATG CCAATTATGT TGATGGCTAC 5520

AACAGACCAA AAGCTTATAT TGCTGCCCAA GGCCCACTGA AATCCACAGC TGAAGATTTC 5580

TGGAGAATGA TATGGGAACA TAATGTGGAA GTTATTGTCA TGATAACAAA CCTCGTGGAG 5640 AAAGGAAGGA GAAAATGTGA TCAGTACTGG CCTGCCGATG GGAGTGAGGA GTACGGGAAC 5700 TTTCTGGTCA CTCAGAAGAG TGTGCAAGTG CTTGCCTATT ATACTGTGAG GAATTTTACT 5760 CTAAGAAACA CAAAAATAAA AAAGGGCTCC CAGAAAGGAA GACCCAGTGG ACGTGTGGTC 5820 ACACAGTATC ACTACACGCA GTGGCCTGAC ATGGGAGTAC CAGAGTACTC CCTGCCAGTG 5880 CTGACCTTTG TGAGAAAGGC AGCCTATGCC AAGCGCCATG CAGTGGGGCC TGTTGTCGTC 5940 CACTGCAGTG CTGGAGTTGG AAGAACAGGC ACATATATTG TGCTAGACAG TATGTTGCAG 6000 CAGATTCAAC ACGAAGGAAC TGTCAACATA TTTGGCTTCT TAAAACACAT CCGTTCACAA 6060 AGAAATTATT TGGTACAAAC TGAGGAGCAA TATGTCTTCA TTCATGATAC ACTGGTTGAG 6120 GCCATACTTA GTAAAGAAAC TGAGGTGCTG GACAGTCATA TTCATGCCTA TGTTAATGCA 6180 CTCCTCATTC CTGGACCAGC AGGCAAAACA AAGCTAGAGA AACAATTCCA GCTCCTGAGC 6240 CAGTCAAATA TACAGCAGAG TGACTATTCT GCAGCCCTAA AGCAATGCAA CAGGGAAAAG 6300 AATCGAACTT CTTCTATCAT CCCTGTGGAA AGATCAAGGG TTGGCATTTC ATCCCTGAGT 6360 GGAGAAGGCA CAGACTACAT CAATGCCTCC TATATCATGG GCTATTACCA GAGCAATGAA 6420 TTCATCATTA CCCAGCACCC TCTCCTTCAT ACCATCAAGG ATTTCTGGAG GATGATATGG 6480 GACCATAATG CCCAACTGGT GGTTATGATT CCTGATGGCC AAAACATGGC AGAAGATGAA 6540 TTTGTTTACT GGCCAAATAA AGATGAGCCT ATAAATTGTG AGAGCTTTAA GGTCACTCTT 6600 ATGGCTGAAG AACACAAATG TCTATCTAAT GAGGAAAAAC TTATAATTCA GGACTTTATC 6660 TTAGAAGCTA CACAGGATGA TTATGTACTT GAAGTGAGGC ACTTTCAGTG TCCTAAATGG 6720 CCAAATCCAG ATAGCCCCAT TAGTAAAACT TTTGAACTTA TAAGTGTTAT AAAAGAAGAA 6780 GCTGCCAATA GGGATGGGCC TATGATTGTT CATGATGAGC ATGGAGGAGT GACGGCAGGA 6840 ACTTTCTGTG CTCTGACAAC CCTTATGCAC CAACTAGAAA AAGAAAATTC CGTGGATGTT 6900 TACCAGGTAG CCAAGATGAT CAATCTGATG AGGCCAGGAG TCTTTGCTGA CATTGAGCAG 6960 TATCAGTTTC TCTACAAAGT GATCCTCAGC CTTGTGAGCA CAAGGCAGGA AGAGAATCCA 7020 TCCACCTCTC TGGACAGTAA TGGTGCAGCA TTGCCTGATG GAAATATAGC TGAGAGCTTA 7080 GAGTCTTTAG TTTAACACAG AAAGGGGTGG GGGGACTCAC ATCTGAGCAT TGTTTTCCTC 7140 TTCCTAAAAT TAGGCAGGAA AATCAGTCTA GTTCTGTTAT CTGTTGATTT CCCATCACCT 7200 GACAGTAACT TTCATGACAT AGGATTCTGC CGCCAAATTT ATATCATTAA CAATGTGTGC 7260 CTTTTTGCAA GACTTGTAAT TTACTTATTA TGTTTGAACT AAAATGATTG AATTTTACAG 7320 TATTTCTAAG AATGGAATTG TGGTATTTTT TTCTGTATTG ATTTTAACAG AAAATTTCAA 7380 TTTATAGAGG TTAGGAATTC CAAACTACAG AAAATGTTTG TTTTTAGTGT CAAATTTTTA 7440 GCTGTATTTG TAGCAATTAT CAGGTTTGCT AGAAATATAA CTTTTAATAC AGTAGCCTGT 7500 AAATAAAACA CTCTTCCATA TGATATTCAA CATTTTACAA CTGCAGTATT CACCTAAAGT 7560 AGAAATAATC TGTTACTTAT TGTAAATACT GCCCTAGTGT CTCCATGGAC CAAATTTATA 7620 TTTATAATTG TAGATTTTTA TATTTTACTA CTGAGTCAAG TTTTCTAGTT CTGTGTAATT 7680 GTTTAGTTTA ATGACGTAGT TCATTAGCTG GTCTTACTCT ACCAGTTTTC TGACATTGTA 7740 TTGTGTTACC TAAGTCATTA ACTTTGTTTC AGCATGTAAT TTTAACTTTT GTGGAAAATA 7800 GAAATACCTT CATTTTGAAA GAAGTTTTTA TGAGAATAAC ACCTTACCAA ACATTGTTCA 7860 AATGGTTTTT ATCCAAGGAA TTGCAAAAAT AAATATAAAT ATTGCCATTA AAAAAAAAAA 7920 AAAAAAAAAA AAAAAAAAAA AAAA

Seq ID NO: 180 Protein sequence: Protein Accession ft: Eos sequence

11 21 31 41 51

1 1 I

MRILKRFLAC I 1QLLCVCRLD W 1ANGYYRQQR KLVEEIGWSY TGALNQKNWG KKYPTCNSPK 60 QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 120 FKASKITFHW GKCNMSSDGS EHSLEGQKFP LEMQIYCFDA DRFSSPEEAV KGKGKLRALS 180 ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 240 TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 300 TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPRWYD TMIEKFAVLY QQLDGEDQTK 360 HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY SDQLIVDMPT DNPELDLFPE 420 LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 480 RSPTRGSEFS GKGDVPNTSL NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND 540 GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS 600 ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG NVWFPSSTDI 660 TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 720 TEVTPHAFTP SSRQQDLVST VNWYSQTTQ PVYNGETPLQ PSYSSEVFPL VTPLLLDNQI 780 LNTTPAASSS DSALHATPVF PSVDVSFESI LSSYDGAPLL PFSSASFSSE LFRHLHTVSQ 840 ILPQVTSATE SDKVPLHASL PVAGGDLLLE PSLAQYSDVL STTHAASETL EFGSESGVLY 900 KTLMFSQVEP PSSDAMMHAR SSGPEPSYAL SDNEGSQHIF TVSYSSAIPV HDSVGVTYQG 960 SLFSGPSHIP IPKSSLITPT ASLLQPTHAL SGDGEWSGAS SDSEFLLPDT DGLTALNISS 1020 PVSVAEFTYT TSVFGDDNKA LSKSEIIYGN ETELQIPSFN EMVYPSESTV MPNMYDNVNK 1080 LNASLQETSV SISSTKGMFP GSLAHTTTKV FDHEISQVPE NNFSVQPTHT VSQASGDTSL 1140 KPVLSANSEP ASSDPASSEM LSPSTQLLFY ETSASFSTEV LLQPSFQASD VDTLLKTVLP 1200 AVPSDPILVE TPKVDKISST MLH I SNSA SSENMLHSTS VPVFDVSPTS HMHSASLQGL 1260 TISYASEKYE PVLLKSESSH QWPSLYSND ELFQTANLEI NQAHPPKGRH VFATPVLSID 1320 EPLNTLINKL IHSDEILTST KSSVTGKVFA GIPTVASDTF VSTDHSVPIG NGHVAITAVS 1380 PHRDGSVTST KLLFPSKATS ELSHSAKSDA GLVGGGEDGD TDDDGDDDDD DRGSDGLSIH 1440 KCMSCSSYRE SQEKVMNDSD THENSLMDQN NPISYSLSEN SEEDNRVTSV SSDSQTGMDR 1500 SPGKSPSANG LSQKHNDGKE ENDIQTGSAL LPLSPESKAW AVLTSDEESG SGQGTSDSLN 1560 ENETSTDFSF ADTNEKDADG ILAAGDSEIT PGFPQSPTSS VTSENSEVFH VSEAEASNSS 1620 HESRIGLAEG LESEKKAVIP LVIVSALTFI CLWLVGILI YWRKCFQTAH FYLEDSTSPR 1680 VISTPPTPIF PISDDVGAIP IKHFPKHVAD LHASSGFTEE FETLKEFYQE VQSCTVDLGI 1740 TADSSNHPDN KHKNRYINIV AYDHSRVKLA QLAEKDGKLT DYINANYVDG YNRPKAYIAA 1800 QGPLKSTAED FWRMIWEHNV EVIVMITNLV EKGRRKCDQY WPADGSEEYG NFLVTQKSVQ 1860 VLAYYTVRNF TLRNTKIKKG SQKGRPSGRV VTQYHYTQWP DMGVPEYSLP VLTFVRKAAY 1920 AKRHAVGPW VHCSAGVGRT GTYIVLDSML QQIQHEGTVN IFGFLKHIRS QRNYLVQTEE 1980 QYVFIHDTLV EAILSKETEV LDSHIHAYVN ALLIPGPAGK TKLEKQFQLL SQSNIQQSDY 2040 SAALKQCNRE KNRTSSIIPV ERSRVGISSL SGEGTDYINA SYIMGYYQSN EFIITQHPLL 2100 HTIKDFWRMI WDHNAQLWM IPDGQNMAED EFVYWPNKDE PINCESFKVT LMAEEHKCLS 2160 NEEKLIIQDF ILEATQDDYV LEVRHFQCPK WPNPDSPISK TFELISVIKE EAANRDGPMI 2220 VHDEHGGVTA GTFCALTTLM HQLEKENSVD VYQVAKMINL MRPGVFADIE QYQFLYKVIL 2280 SLVSTRQEEN PSTSLDSNGA ALPDGNIAES LESLV

Seq ID NO: 181 DNA sequence

Nucleic Acid Accession ft: Eos sequence Co ng sequence: 148-4518

60

120

CGGCGAGGGG CCGCAGACCG TCTGGAAATG CGAATCCTAA AGCGTTTCCT CGCTTGCATT 180

CAGCTCCTCT GTGTTTGCCG CCTGGATTGG GCTAATGGAT ACTACAGACA ACAGAGAAAA 240

CTTGTTGAAG AGATTGGCTG GTCCTATACA GGAGCACTGA ATCAAAAAAA TTGGGGAAAG 300

AAATATCCAA CATGTAATAG CCCAAAACAA TCTCCTATCA ATATTGATGA AGATCTTACA 360

CAAGTAAATG TGAATCTTAA GAAACTTAAA TTTCAGGGTT GGGATAAAAC ATCATTGGAA 420

AACACATTCA TTCATAACAC TGGGAAAACA GTGGAAATTA ATCTCACTAA TGACTACCGT 480

GTCAGCGGAG GAGTTTCAGA AATGGTGTTT AAAGCAAGCA AGATAACTTT TCACTGGGGA 540

AAATGCAATA TGTCATCTGA TGGATCAGAG CATAGTTTAG AAGGACAAAA ATTTCCACTT 600

GAGATGCAAA TCTACTGCTT TGATGCGGAC CGATTTTCAA GTTTTGAGGA AGCAGTCAAA 660

GGAAAAGGGA AGTTAAGAGC TTTATCCATT TTGTTTGAGG TTGGGACAGA AGAAAATTTG 720

GATTTCAAAG CGATTATTGA TGGAGTCGAA AGTGTTAGTC GTTTTGGGAA GCAGGCTGCT 780

TTAGATCCAT TCATACTGTT GAACCTTCTG CCAAACTCAA CTGACAAGTA TTACATTTAC 840

AATGGCTCAT TGACATCTCC TCCCTGCACA GACACAGTTG ACTGGATTGT TTTTAAAGAT 900

ACAGTTAGCA TCTCTGAAAG CCAGTTGGCT GTTTTTTGTG AAGTTCTTAC AATGCAACAA 960

TCTGGTTATG TCATGCTGAT GGACTACTTA CAAAACAATT TTCGAGAGCA ACAGTACAAG 1020

TTCTCTAGAC AGGTGTTTTC CTCATACACT GGAAAGGAAG AGATTCATGA AGCAGTTTGT 1080

AGTTCAGAAC CAGAAAATGT TCAGGCTGAC CCAGAGAATT ATACCAGCCT TCTTGTTACA 1140

TGGGAAAGAC CTCGAGTCGT TTATGATACC ATGATTGAGA AGTTTGCAGT TTTGTACCAG 1200

CAGTTGGATG GAGAGGACCA AACCAAGCAT GAATTTTTGA CAGATGGCTA TCAAGACTTG 1260

GGTGCTATTC TCAATAATTT GCTACCCAAT ATGAGTTATG TTCTTCAGAT AGTAGCCATA 1320

TGCACTAATG GCTTATATGG AAAATACAGC GACCAACTGA TTGTCGACAT GCCTACTGAT 1380

AATCCTGAAC TTGATCTTTT CCCTGAATTA ATTGGAACTG AAGAAATAAT CAAGGAGGAG 1440

GAAGAGGGAA AAGACATTGA AGAAGGCGCT ATTGTGAATC CTGGTAGAGA CAGTGCTACA 1500

AACCAAATCA GGAAAAAGGA ACCCCAGATT TCTACCACAA CACACTACAA TCGCATAGGG 1560

ACGAAATACA ATGAAGCCAA GACTAACCGA TCCCCAACAA GAGGAAGTGA ATTCTCTGGA 1620

AAGGGTGATG TTCCCAATAC ATCTTTAAAT TCCACTTCCC AACCAGTCAC TAAATTAGCC 1680

ACAGAAAAAG ATATTTCCTT GACTTCTCAG ACTGTGACTG AACTGCCACC TCACACTGTG 1740

GAAGGTACTT CAGCCTCTTT AAATGATGGC TCTAAAACTG TTCTTAGATC TCCACATATG ^* 1800

AACTTGTCGG GGACTGCAGA ATCCTTAAAT ACAGTTTCTA TAACAGAATA TGAGGAGGAG 1860

AGTTTATTGA CCAGTTTCAA GCTTGATACT GGAGCTGAAG ATTCTTCAGG CTCCAGTCCC 1920

GCAACTTCTG CTATCCCATT CATCTCTGAG AACATATCCC AAGGGTATAT ATTTTCCTCC 1980

GAAAACCCAG AGACAATAAC ATATGATGTC CTTATACCAG AATCTGCTAG AAATGCTTCC 2040

GAAGATTCAA CTTCATCAGG TTCAGAAGAA TCACTAAAGG ATCCTTCTAT GGAGGGAAAT 2100

GTGTGGTTTC CTAGCTCTAC AGACATAACA GCACAGGCCG ATGTTGGATC AGGCAGAGAG 2160

AGCTTTCTCC AGACTAATTA CACTGAGATA CGTGTTGATG AATCTGAGAA GACAACCAAG 2220

TCCTTTTCTG CAGGCCCAGT GATGTCACAG GGTCCCTCAG TTACAGATCT GGAAATGCCA 2280

CATTATTCTA CCTTTGCCTA CTTCCCAACT GAGGTAACAC CTCATGCTTT TACCCCATCC 2340

TCCAGACAAC AGGATTTGGT CTCCACGGTC AACGTGGTAT ACTCGCAGAC AACCCAACCG 2400

GTATACAATG CAGAGGCCAG TAATAGTAGC CATGAGTCTC GTATTGGTCT AGCTGAGGGG 2460

TTGGAATCCG AGAAGAAGGC AGTTATACCC CTTGTGATCG TGTCAGCCCT GACTTTTATC 2520

TGTCTAGTGG TTCTTGTGGG TATTCTCATC TACTGGAGGA AATGCTTCCA GACTGCACAC 2580

TTTTACTTAG AGGACAGTAC ATCCCCTAGA GTTATATCCA CACCTCCAAC ACCTATCTTT 2640

CCAATTTCAG ATGATGTCGG AGCAATTCCA ATAAAGCACT TTCCAAAGCA TGTTGCAGAT 2700

TTACATGCAA GTAGTGGGTT TACTGAAGAA TTTGAGACAC TGAAAGAGTT TTACCAGGAA 2760

GTGCAGAGCT GTACTGTTGA CTTAGGTATT ACAGCAGACA GCTCCAACCA CCCAGACAAC 2820

AAGCACAAGA ATCGATACAT AAATATCGTT GCCTATGATC ATAGCAGGGT TAAGCTAGCA 2880

CAGCTTGCTG AAAAGGATGG CAAACTGACT GATTATATCA ATGCCAATTA TGTTGATGGC 2940

TACAACAGAC CAAAAGCTTA TATTGCTGCC CAAGGCCCAC TGAAATCCAC AGCTGAAGAT 3000

TTCTGGAGAA TGATATGGGA ACATAATGTG GAAGTTATTG TCATGATAAC AAACCTCGTG 3060

GAGAAAGGAA GGAGAAAATG TGATCAGTAC TGGCCTGCCG ATGGGAGTGA GGAGTACGGG 3120

AACTTTCTGG TCACTCAGAA GAGTGTGCAA GTGCTTGCCT ATTATACTGT GAGGAATTTT 3180

ACTCTAAGAA ACACAAAAAT AAAAAAGGGC TCCCAGAAAG GAAGACCCAG TGGACGTGTG 3240

GTCACACAGT ATCACTACAC GCAGTGGCCT GACATGGGAG TACCAGAGTA CTCCCTGCCA 3300

GTGCTGACCT TTGTGAGAAA GGCAGCCTAT GCCAAGCGCC ATGCAGTGGG GCCTGTTGTC 3360

GTCCACTGCA GTGCTGGAGT TGGAAGAACA GGCACATATA TTGTGCTAGA CAGTATGTTG 3420

CAGCAGATTC AACACGAAGG AACTGTCAAC ATATTTGGCT TCTTAAAACA CATCCGTTCA 3480

CAAAGAAATT ATTTGGTACA AACTGAGGAG CAATATGTCT TCATTCATGA TACACTGGTT 3540

GAGGCCATAC TTAGTAAAGA AACTGAGGTG CTGGACAGTC ATATTCATGC CTATGTTAAT 3600

GCACTCCTCA TTCCTGGACC AGCAGGCAAA ACAAAGCTAG AGAAACAATT CCAGCTCCTG 3660

AGCCAGTCAA ATATACAGCA GAGTGACTAT TCTGCAGCCC TAAAGCAATG CAACAGGGAA 3720

AAGAATCGAA CTTCTTCTAT CATCCCTGTG GAAAGATCAA GGGTTGGCAT TTCATCCCTG 3780

AGTGGAGAAG GCACAGACTA CATCAATGCC TCCTATATCA TGGGCTATTA CCAGAGCAAT 3840

GAATTCATCA TTACCCAGCA CCCTCTCCTT CATACCATCA AGGATTTCTG GAGGATGATA 3900

TGGGACCATA ATGCCCAACT GGTGGTTATG ATTCCTGATG GCCAAAACAT GGCAGAAGAT 3960

GAATTTGTTT ACTGGCCAAA TAAAGATGAG CCTATAAATT GTGAGAGCTT TAAGGTCACT 4020

CTTATGGCTG AAGAACACAA ATGTCTATCT AATGAGGAAA AACTTATAAT TCAGGACTTT 4080

ATCTTAGAAG CTACACAGGA TGATTATGTA CTTGAAGTGA GGCACTTTCA GTGTCCTAAA 4140

TGGCCAAATC CAGATAGCCC CATTAGTAAA ACTTTTGAAC TTATAAGTGT TATAAAAGAA 4200

GAAGCTGCCA ATAGGGATGG GCCTATGATT GTTCATGATG AGCATGGAGG AGTGACGGCA 4260

GGAACTTTCT GTGCTCTGAC AACCCTTATG CACCAACTAG AAAAAGAAAA TTCCGTGGAT 4320

GTTTACCAGG TAGCCAAGAT GATCAATCTG ATGAGGCCAG GAGTCTTTGC TGACATTGAG 4380

CAGTATCAGT TTCTCTACAA AGTGATCCTC AGCCTTGTGA GCACAAGGCA GGAAGAGAAT 4440

CCATCCACCT CTCTGGACAG TAATGGTGCA GCATTGCCTG ATGGAAATAT AGCTGAGAGC 4500

TTAGAGTCTT TAGTTTAACA CAGAAAGGGG TGGGGGGACT CACATCTGAG CATTGTTTTC 4560

CTCTTCCTAA AATTAGGCAG GAAAATCAGT CTAGTTCTGT TATCTGTTGA TTTCCCATCA 4620

CCTGACAGTA ACTTTCATGA CATAGGATTC TGCCGCCAAA TTTATATCAT TAACAATGTG 4680

TGCCTTTTTG CAAGACTTGT AATTTACTTA TTATGTTTGA ACTAAAATGA TTGAATTTTA 4740

CAGTATTTCT AAGAATGGAA TTGTGGTATT TTTTTCTGTA TTGATTTTAA CAGAAAATTT 4800

CAATTTATAG AGGTTAGGAA TTCCAAACTA CAGAAAATGT TTGTTTTTAG TGTCAAATTT 4860

TTAGCTGTAT TTGTAGCAAT TATCAGGTTT GCTAGAAATA TAACTTTTAA TACAGTAGCC 4920

TGTAAATAAA ACACTCTTCC ATATGATATT CAACATTTTA CAACTGCAGT ATTCACCTAA 4980 AGTAGAAATA ATCTGTTACT TATTGTAAAT ACTGCCCTAG TGTCTCCATG GACCAAATTT 5040

ATATTTATAA TTGTAGATTT TTATATTTTA CTACTGAGTC AAGTTTTCTA GTTCTGTGTA 5100

ATTGTTTAGT TTAATGACGT AGTTCATTAG CTGGTCTTAC TCTACCAGTT TTCTGACATT 5160

GTATTGTGTT ACCTAAGTCA TTAACTTTGT TTCAGCATGT AATTTTAACT TTTGTGGAAA 5220

5 ATAGAAATAC CTTCATTTTG AAAGAAGTTT TTATGAGAAT AACACCTTAC CAAACATTGT 5280

TCAAATGGTT TTTATCCAAG GAATTGCAAA AATAAATATA AATATTGCCA TTAAAAAAAA 5340 AAAAAAAAAA AAAAAAAAAA AAAAAAA

10 Seq ID NO: 182 Protein sequence :

Protein Accession ft : Eos sequence

1 11 21 31 41 51

₁ ID_C MIRILKRPLAC I IQLLCVCRLD W IANGYYRQQR K ILVEEIGWSY T IGALNQKNWG K IKYPTCNSPK 60

QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 120

FKASKITFHW GKCNMSSDGS EHSLEGQKFP LEMQIYCFDA DRFSSFEEAV KGKGKLRALS 180

ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 240

TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 300 0 TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPR YD TMIEKFAVLY QQLDGEDQTK 360

HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY SDQLIVDMPT DNPELDLFPE 420

LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 480

RSPTRGSEFS GKGDVPNTSL NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND 540

GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS 600 5 ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG NVWFPSSTDI 660

TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 720

TEVTPHAFTP SSRQQDLVST VNWYSQTTQ PVYNAEASNS SHESRIGLAE GLESEKKAVI 780

PLVIVSALTP ICLWLVGIL IYWRKCFQTA HFYLEDSTSP RVISTPPTPI FPISDDVGAI 840

PIKHFPKHVA DLHASSGFTE EFETLKEFYQ EVQSCTVDLG ITADSSNHPD NKHKNRYINI 900 0 VAYDHSRVKL AQLAEKDGKL TDYINANYVD GYNRPKAYIA AQGPLKSTAE DFWRMIWEHN 960

VEVIVMITNL VEKGRRKCDQ YWPADGSEEY GNFLVTQKSV QVLAYYTVRN FTLRNTKIKK 1020

GSQKGRPSGR WTQYHYTQW PDMGVPEYSL PVLTFVRKAA YAKRHAVGPV HCSAGVGR 1080

TGTYIVLDSM LQQIQHEGTV NIFGFLKHIR SQRNYLVQTE EQYVFIHDTL VEAILSKETE 1140

VLDSHIHAYV NALLIPGPAG KTKLEKQFQL LSQSNIQQSD YSAALKQCNR EKNRTSSIIP 1200 5 VERSRVGISS LSGEGTDYIN ASYIMGYYQS NEFIITQHPL LHTIKDFWRM IWDHNAQLW 1260

MIPDGQNMAE DEFVYWPNKD EPINCESFKV TLMAEEHKCL SNEEKLIIQD FILEATQDDY 1320

VLEVRHFQCP KWPNPDSPIS KTFELISVIK EEAANRDGPM IVHDEHGGVT AGTFCALTTL 1380

MHQLEKENSV DVYQVAKMIN LMRPGVFADI EQYQFLYKVI LSLVSTRQEE NPSTSLDSNG 1440

AALPDGNIAE SLESLV 0

Seq ID NO: 183 DNA sequence

Nucleic Acid Accession ft: EOS sequence

Coding sequence: 148-4494 5 1 11 21 31 41 51

I I I I I I

CACACATACG CACGCACGAT CTCACTTCGA TCTATACACT GGAGGATTAA AACAAACAAA 60

CAAAAAAAAC ATTTCCTTCG CTCCCCCTCC CTCTCCACTC TGAGAAGCAG AGGAGCCGCA 120

CGGCGAGGGG CCGCAGACCG TCTGGAAATG CGAATCCTAA AGCGTTTCCT CGCTTGCATT 180 0 CAGCTCCTCT GTGTTTGCCG CCTGGATTGG GCTAATGGAT ACTACAGACA ACAGAGAAAA 240

CTTGTTGAAG AGATTGGCTG GTCCTATACA GGAGCACTGA ATCAAAAAAA TTGGGGAAAG 300

AAATATCCAA CATGTAATAG CCCAAAACAA TCTCCTATCA ATATTGATGA AGATCTTACA 360

CAAGTAAATG TGAATCTTAA GAAACTTAAA TTTCAGGGTT GGGATAAAAC ATCATTGGAA 420

AACACATTCA TTCATAACAC TGGGAAAACA GTGGAAATTA ATCTCACTAA TGACTACCGT 480 5 GTCAGCGGAG GAGTTTCAGA AATGGTGTTT AAAGCAAGCA AGATAACTTT TCACTGGGGA 540

AAATGCAATA TGTCATCTGA TGGATCAGAG CATAGTTTAG AAGGACAAAA ATTTCCACTT 600

GAGATGCAAA TCTACTGCTT TGATGCAGAC CGATTTTCAA GTTTTGAGGA AGCAGTCAAA 660

GGAAAAGGGA AGTTAAGAGC TTTATCCATT TTGTTTGAGG TTGGGACAGA AGAAAATTTG 720

GATTTCAAAG CGATTATTGA TGGAGTCGAA AGTGTTAGTC GTTTTGGGAA GCAGGCTGCT 780 0 TTAGATCCAT TCATACTGTT GAACCTTCTG CCAAACTCAA CTGACAAGTA TTACATTTAC 840

AATGGCTCAT TGACATCTCC TCCCTGCACA GACACAGTTG ACTGGATTGT TTTTAAAGAT 900

ACAGTTAGCA TCTCTGAAAG CCAGTTGGCT GTTTTTTGTG AAGTTCTTAC AATGCAACAA 960

TCTGGTTATG TCATGCTGAT GGACTACTTA CAAAACAATT TTCGAGAGCA ACAGTACAAG 1020

TTCTCTAGAC AGGTGTTTTC CTCATACACT GGAAAGGAAG AGATTCATGA AGCAGTTTGT 1080 5 AGTTCAGAAC CAGAAAATGT TCAGGCTGAC CCAGAGAATT ATACCAGCCT TCTTGTTACA 1140

TGGGAAAGAC CTCGAGTCGT TTATGATACC ATGATTGAGA AGTTTGCAGT TTTGTACCAG 1200

CAGTTGGATG GAGAGGACCA AACCAAGCAT GAATTTTTGA CAGATGGCTA TCAAGACTTG 1260

GGTGCTATTC TCAATAATTT GCTACCCAAT ATGAGTTATG TTCTTCAGAT AGTAGCCATA 1320

TGCACTAATG GCTTATATGG AAAATACAGC GACCAACTGA TTGTCGACAT GCCTACTGAT 1380 0 AATCCTGAAC TTGATCTTTT CCCTGAATTA ATTGGAACTG AAGAAATAAT CAAGGAGGAG 1440

GAAGAGGGAA AAGACATTGA AGAAGGCGCT ATTGTGAATC CTGGTAGAGA CAGTGCTACA 1500

AACCAAATCA GGAAAAAGGA ACCCCAGATT TCTACCACAA CACACTACAA TCGCATAGGG 1560

ACGAAATACA ATGAAGCCAA GACTAACCGA TCCCCAACAA GAGGAAGTGA ATTCTCTGGA 1620

AAGGGTGATG TTCCCAATAC ATCTTTAAAT TCCACTTCCC AACCAGTCAC TAAATTAGCC 1680 5 ACAGAAAAAG ATATTTCCTT GACTTCTCAG ACTGTGACTG AACTGCCACC TCACACTGTG 1740

GAAGGTACTT CAGCCTCTTT AAATGATGGC TCTAAAACTG TTCTTAGATC TCCACATATG 1800

AACTTGTCGG GGACTGCAGA ATCCTTAAAT ACAGTTTCTA TAACAGAATA TGAGGAGGAG 1860

AGTTTATTGA CCAGTTTCAA GCTTGATACT GGAGCTGAAG ATTCTTCAGG CTCCAGTCCC 1920

GCAACTTCTG CTATCCCATT CATCTCTGAG AACATATCCC AAGGGTATAT ATTTTCCTCC 1980 0 GAAAACCCAG AGACAATAAC ATATGATGTC CTTATACCAG AATCTGCTAG AAATGCTTCC 2040

GAAGATTCAA CTTCATCAGG TTCAGAAGAA TCACTAAAGG ATCCTTCTAT GGAGGGAAAT 2100

GTGTGGTTTC CTAGCTCTAC AGACATAACA GCACAGCCCG ATGTTGGATC AGGCAGAGAG 2160

AGCTTTCTCC AGACTAATTA CACTGAGATA CGTGTTGATG AATCTGAGAA GACAACCAAG 2220

TCCTTTTCTG CAGGCCCAGT GATGTCACAG GGTCCCTCAG TTACAGATCT GGAAATGCCA 2280 5 CATTATTCTA CCTTTGCCTA CTTCCCAACT GAGGTAACAC CTCATGCTTT TACCCCATCC 2340

TCCAGACAAC AGGATTTGGT CTCCACGGTC AACGTGGTAT ACTCGCAGAC AACCCAACCG 2400

GTATACAATG AGGCCAGTAA TAGTAGCCAT GAGTCTCGTA TTGGTCTAGC TGAGGGGTTG 2460 GAATCCGAGA AGAAGGCAGT TATACCCCTT GTGATCGTGT CAGCCCTGAC TTTTATCTGT 2520

CTAGTGGTTC TTGTGGGTAT TCTCATCTAC TGGAGGAAAT GCTTCCAGAC TGCACACTTT 2580

TACTTAGAGG ACAGTACATC CCCTAGAGTT ATATCCACAC CTCCAACACC TATCTTTCCA 2640

ATTTCAGATG ATGTCGGAGC AATTCCAATA AAGCACTTTC CAAAGCATGT TGCAGATTTA 2700

CATGCAAGTA GTGGGTTTAC TGAAGAATTT GAGGAAGTGC AGAGCTGTAC TGTTGACTTA 2760

GGTATTACAG CAGACAGCTC CAACCACCCA GACAACAAGC ACAAGAATCG ATACATAAAT 2820

ATCGTTGCCT ATGATCATAG CAGGGTTAAG CTAGCACAGC TTGCTGAAAA GGATGGCAAA 2880

CTGACTGATT ATATCAATGC CAATTATGTT GATGGCTACA ACAGACCAAA AGCTTATATT 2940

GCTGCCCAAG GCCCACTGAA ATCCACAGCT GAAGATTTCT GGAGAATGAT ATGGGAACAT 3000

AATGTGGAAG TTATTGTCAT GATAACAAAC CTCGTGGAGA AAGGAAGGAG AAAATGTGAT 3060

CAGTACTGGC CTGCCGATGG GAGTGAGGAG TACGGGAACT TTCTGGTCAC TCAGAAGAGT 3120

GTGCAAGTGC TTGCCTATTA TACTGTGAGG AATTTTACTC TAAGAAACAC AAAAATAAAA 3180

AAGGGCTCCC AGAAAGGAAG ACCCAGTGGA CGTGTGGTCA CACAGTATCA CTACACGCAG 3240

TGGCCTGACA TGGGAGTACC AGAGTACTCC CTGCCAGTGC TGACCTTTGT GAGAAAGGCA 3300

GCCTATGCCA AGCGCCATGC AGTGGGGCCT GTTGTCGTCC ACTGCAGTGC TGGAGTTGGA 3360

AGAACAGGCA CATATATTGT GCTAGACAGT ATGTTGCAGC AGATTCAACA CGAAGGAACT 3420

GTCAACATAT TTGGCTTCTT AAAACACATC CGTTCACAAA GAAATTATTT GGTACAAACT 3480

GAGGAGCAAT ATGTCTTCAT TCATGATACA CTGGTTGAGG CCATACTTAG TAAAGAAACT 3540

GAGGTGCTGG ACAGTCATAT TCATGCCTAT GTTAATGCAC TCCTCATTCC TGGACCAGCA 3600

GGCAAAACAA AGCTAGAGAA ACAATTCCAG CTCCTGAGCC AGTCAAATAT ACAGCAGAGT 3660

GACTATTCTG CAGCCCTAAA GCAATGCAAC AGGGAAAAGA ATCGAACTTC TTCTATCATC 3720

CCTGTGGAAA GATCAAGGGT TGGCATTTCA TCCCTGAGTG GAGAAGGCAC AGACTACATC 3780

AATGCCTCCT ATATCATGGG CTATTACCAG AGCAATGAAT TCATCATTAC CCAGCACCCT 3840

CTCCTTCATA CCATCAAGGA TTTCTGGAGG ATGATATGGG ACCATAATGC CCAACTGGTG 3900

GTTATGATTC CTGATGGCCA AAACATGGCA GAAGATGAAT TTGTTTACTG GCCAAATAAA 3960

GATGAGCCTA TAAATTGTGA GAGCTTTAAG GTCACTCTTA TGGCTGAAGA ACACAAATGT 4020

CTATCTAATG AGGAAAAACT TATAATTCAG GACTTTATCT TAGAAGCTAC ACAGGATGAT 4080

TATGTACTTG AAGTGAGGCA CTTTCAGTGT CCTAAATGGC CAAATCCAGA TAGCCCCATT 4140

AGTAAAACTT TTGAACTTAT AAGTGTTATA AAAGAAGAAG CTGCCAATAG GGATGGGCCT 4200

ATGATTGTTC ATGATGAGCA TGGAGGAGTG ACGGCAGGAA CTTTCTGTGC TCTGACAACC 4260

CTTATGCACC AACTAGAAAA AGAAAATTCC GTGGATGTTT ACCAGGTAGC CAAGATGATC 4320

AATCTGATGA GGCCAGGAGT CTTTGCTGAC ATTGAGCAGT ATCAGTTTCT CTACAAAGTG 4380

ATCCTCAGCC TTGTGAGCAC AAGGCAGGAA GAGAATCCAT CCACCTCTCT GGACAGTAAT 4440

GGTGCAGCAT TGCCTGATGG AAATATAGCT GAGAGCTTAG AGTCTTTAGT TTAACACAGA 4500

AAGGGGTGGG ^'GGGACTCACA TCTGAGCATT GTTTTCCTCT TCCTAAAATT AGGCAGGAAA 4560

ATCAGTCTAG TTCTGTTATC TGTTGATTTC CCATCACCTG ACAGTAACTT TCATGACATA 4620

GGATTCTGCC GCCAAATTTA TATCATTAAC AATGTGTGCC TTTTTGCAAG ACTTGTAATT 4680

TACTTATTAT GTTTGAACTA AAATGATTGA ATTTTACAGT ATTTCTAAGA ATGGAATTGT 4740

GGTATTTTTT TCTGTATTGA TTTTAACAGA AAATTTCAAT TTATAGAGGT TAGGAATTCC 4800

AAACTACAGA AAATGTTTGT TTTTAGTGTC AAATTTTTAG CTGTATTTGT AGCAATTATC 4860

AGGTTTGCTA GAAATATAAC TTTTAATACA GTAGCCTGTA AATAAAACAC TCTTCCATAT 4920

GATATTCAAC ATTTTACAAC TGCAGTATTC ACCTAAAGTA GAAATAATCT GTTACTTATT 4980

GTAAATACTG CCCTAGTGTC TCCATGGACC AAATTTATAT TTATAATTGT AGATTTTTAT 5040

ATTTTACTAC TGAGTCAAGT TTTCTAGTTC TGTGTAATTG TTTAGTTTAA TGACGTAGTT 5100

CATTAGCTGG TCTTACTCTA CCAGTTTTCT GACATTGTAT TGTGTTACCT AAGTCATTAA 5160

CTTTGTTTCA GCATGTAATT TTAACTTTTG TGGAAAATAG AAATACCTTC ATTTTGAAAG 5220

AAGTTTTTAT GAGAATAACA CCTTACCAAA CATTGTTCAA ATGGTTTTTA TCCAAGGAAT 5280

TGCAAAAATA AATATAAATA TTGCCATTAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 5340 AAA

Seq ID NO: 184 Protein sequence: Protein Accession ft: EOS sequence

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I I I I I I

MRILKRFLAC IQLLCVCRLD WANGYYRQQR KLVEEIGWSY TGALNQKNWG KKYPTCNSPK 60 QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 120 FKASKITFHW GKCNMSSDGS EHSLEGQKPP LEMQIYCFDA DRFSSFEEAV KGKGKLRALS 180 ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 240 TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 300 TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPRWYD TMIEKFAVLY QQLDGEDQTK 360 HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY SDQLIVDMPT DNPELDLFPE 420 LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 480 RSPTRGSEFS GKGDVPNTSL NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND 540 GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS 600 ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG NVWFPSSTDI 660 TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 720 TEVTPHAFTP SSRQQDLVST VNWYSQTTQ PVYNEASNSS HESRIGLAEβ LESEKKAVIP 780 LVIVSALTFI CLWLVGILI YWRKCFQTAH FYLEDSTSPR VISTPPTPIF PISDDVGAIP 840 IKHFPKΉVAD HASSGFTEE FEEVQSCTVD GITADSSNH PDNKHKNRYI NIVAYDHSRV 900 KLAQLAEKDG KLTDYINANY VDGYNRPKAY IAAQGPLKST AEDFWRMIWE HNVEVIVMIT 960

NLVEKGRRKC DQYWPADGSE EYGNFLVTQK SVQVLAYYTV RNFTLRNTKI KKGSQKGRPS 1020

GRWTQYHYT QWPDMGVPEY SLPVLTFVRK AAYAKRHAVG P WHCSAGV GRTGTYIVLD 1080

SMLQQIQHEG TVNIFGFLKH IRSQRNYLVQ TEEQYVFIHD TLVEAILSKE TEVLDSHIHA 1140

YVNALLIPGP AGKTKLEKQF QLLSQSNIQQ SDYSAALKQC NREKNRTSSI IPVERSRVGI 1200

SSLSGEGTDY INASYIMGYY QSNEFIITQH PLLHTIKDFW RMIWDHNAQL WMIPDGQNM 1260

AEDEFVYWPN KDEPINCESF KVTLMAEEHK CLSNEEKLII QDFILEATQD DYVLEVRHFQ 1320

CPKWPNPDSP ISKTFELISV IKEEAANRDG PMIVHDEHGG VTAGTFCALT TLMHQLEKEN 1380

SVDVYQVAKM INLMRPGVFA DIEQYQFLYK VILSLVSTRQ EENPSTSLDS NGAALPDGNI 1440 AESLESLV

Seq ID NO: 185 DNA sequence

Nucleic Acid Accession ft: EOS sequence

Coding sequence: 501-4514

1 11 21 31 41 51 I I I I I I

CACACATACG CACGCACGAT CTCACTTCGA TCTATACACT GGAGGATTAA AACAAACAAA 60

CAAAAAAAAC ATTTCCTTCG CTCCCCCTCC CTCTCCACTC TGAGAAGCAG AGGAGCCGCA 120

CGGCGAGGGG CCGCAGACCG TCTGGAAATG CGAATCCTAA AGCGTTTCCT CGCTTGCATT 180

CAGCTCCTCT GTGTTTGCCG CCTGGATTGG GCTAATGGAT ACTACAGACA ACAGAGAAAA 240

CTTGTTGAAG AGATTGGCTG GTCCTATACA GGAGCACTGA ATCAAAAAAT TGGGGAAAGA 300

AATATCCAAC ATGTAATAGC CCAAAACAAT CTCCTATCAA TATTGATGAA GATCTTACAC 360

AAGTAAATGT GAATCTTAAG AAACTTAAAT TTCAGGGTTG GGATAAAACA TCATTGGAAA 420

ACACATTCAT TCATAACACT GGGAAAACAG TGGAAATTAA TCTCACTAAT GACTACCGTG 480

TCAGCGGAGG AGTTTCAGAA ATGGTGTTTA AAGCAAGCAA GATAACTTTT CACTGGGGAA 540

AATGCAATAT GTCATCTGAT GGATCAGAGC ATAGTTTAGA AGGACAAAAA TTTCCACTTG 600

AGATGCAAAT CTACTGCTTT GATGCGGACC GATTTTCAAG TTTTGAGGAA GCAGTCAAAG 660

GAAAAGGGAA GTTAAGAGCT TTATCCATTT TGTTTGAGGT TGGGACAGAA GAAAATTTGG 720

ATTTCAAAGC GATTATTGAT GGAGTCGAAA GTGTTAGTCG TTTTGGGAAG CAGGCTGCTT 780

TAGATCCATT CATACTGTTG AACCTTCTGC CAAACTCAAC TGACAAGTAT TACATTTACA 840

ATGGCTCATT GACATCTCCT CCCTGCACAG ACACAGTTGA CTGGATTGTT TTTAAAGATA 900

CAGTTAGCAT CTCTGAAAGC CAGTTGGCTG TTTTTTGTGA AGTTCTTACA ATGCAACAAT 960

CTGGTTATGT CATGCTGATG GACTACTTAC AAAACAATTT TCGAGAGCAA CAGTACAAGT 1020

TCTCTAGACA GGTGTTTTCC TCATACACTG GAAAGGAAGA GATTCATGAA GCAGTTTGTA 1080

GTTCAGAACC AGAAAATGTT CAGGCTGACC CAGAGAATTA TACCAGCCTT CTTGTTACAT 1140

GGGAAAGACC TCGAGTCGTT TATGATACCA TGATTGAGAA GTTTGCAGTT TTGTACCAGC 1200

AGTTGGATGG AGAGGACCAA ACCAAGCATG AATTTTTGAC AGATGGCTAT CAAGACTTGG 1260

GTGCTATTCT CAATAATTTG CTACCCAATA TGAGTTATGT TCTTCAGATA GTAGCCATAT 1320

GCACTAATGG CTTATATGGA AAATACAGCG ACCAACTGAT TGTCGACATG CCTACTGATA 1380

ATCCTGAACT TGATCTTTTC CCTGAATTAA TTGGAACTGA AGAAATAATC AAGGAGGAGG 1440

AAGAGGGAAA AGACATTGAA GAAGGCGCTA TTGTGAATCC TGGTAGAGAC AGTGCTACAA 1500

ACCAAATCAG GAAAAAGGAA CCCCAGATTT CTACCACAAC ACACTACAAT CGCATAGGGA 1560

CGAAATACAA TGAAGCCAAG ACTAACCGAT CCCCAACAAG AGGAAGTGAA TTCTCTGGAA 1620

AGGGTGATGT TCCCAATACA TCTTTAAATT CCACTTCCCA ACCAGTCACT AAATTAGCCA 1680

CAGAAAAAGA TATTTCCTTG ACTTCTCAGA CTGTGACTGA ACTGCCACCT CACACTGTGG 1740

AAGGTACTTC AGCCTCTTTA AATGATGGCT CTAAAACTGT TCTTAGATCT CCACATATGA 1800

ACTTGTCGGG GACTGCAGAA TCCTTAAATA CAGTTTCTAT AACAGAATAT GAGGAGGAGA 1860

GTTTATTGAC CAGTTTCAAG CTTGATACTG GAGCTGAAGA TTCTTCAGGC TCCAGTCCCG 1920

CAACTTCTGC TATCCCATTC ATCTCTGAGA ACATATCCCA AGGGTATATA TTTTCCTCCG 1980

AAAACCCAGA GACAATAACA TATGATGTCC TTATACCAGA ATCTGCTAGA AATGCTTCCG 2040

AAGATTCAAC TTCATCAGGT TCAGAAGAAT CACTAAAGGA TCCTTCTATG GAGGGAAATG 2100

TGTGGTTTCC TAGCTCTACA GACATAACAG CACAGCCCGA TGTTGGATCA GGCAGAGAGA 2160

GCTTTCTCCA GACTAATTAC ACTGAGATAC GTGTTGATGA ATCTGAGAAG ACAACCAAGT 2220

CCTTTTCTGC AGGCCCAGTG ATGTCACAGG GTCCCTCAGT TACAGATCTG GAAATGCCAC 2280

ATTATTCTAC CTTTGCCTAC TTCCCAACTG AGGTAACACC TCATGCTTTT ACCCCATCCT 2340

CCAGACAACA GGATTTGGTC TCCACGGTCA ACGTGGTATA CTCGCAGACA ACCCAACCGG 2400

TATACAATGA GGCCAGTAAT AGTAGCCATG AGTCTCGTAT TGGTCTAGCT GAGGGGTTGG 2460

AATCCGAGAA GAAGGCAGTT ATACCCCTTG TGATCGTGTC AGCCCTGACT TTTATCTGTC 2520

TAGTGGTTCT TGTGGGTATT CTCATCTACT GGAGGAAATG CTTCCAGACT GCACACTTTT 2580

ACTTAGAGGA CAGTACATCC CCTAGAGTTA TATCCACACC TCCAACACCT ATCTTTCCAA 2640

TTTCAGATGA TGTCGGAGCA ATTCCAATAA AGCACTTTCC AAAGCATGTT GCAGATTTAC 2700

ATGCAAGTAG TGGGTTTACT GAAGAATTTG AGACACTGAA AGAGTTTTAC CAGGAAGTGC 2760

AGAGCTGTAC TGTTGACTTA GGTATTACAG CAGACAGCTC CAACCACCCA GACAACAAGC 2820

ACAAGAATCG ATACATAAAT ATCGTTGCCT ATGATCATAG CAGGGTTAAG CTAGCACAGC 2880

TTGCTGAAAA GGATGGCAAA CTGACTGATT ATATCAATGC CAATTATGTT GATGGCTACA 2940

ACAGACCAAA AGCTTATATT GCTGCCCAAG GCCCACTGAA ATCCACAGCT GAAGATTTCT 3000

GGAGAATGAT ATGGGAACAT AATGTGGAAG TTATTGTCAT GATAACAAAC CTCGTGGAGA 3060

AAGGAAGGAG AAAATGTGAT CAGTACTGGC CTGCCGATGG GAGTGAGGAG TACGGGAACT 3120

TTCTGGTCAC TCAGAAGAGT GTGCAAGTGC TTGCCTATTA TACTGTGAGG AATTTTACTC 3180

TAAGAAACAC AAAAATAAAA AAGGGCTCCC AGAAAGGAAG ACCCAGTGGA CGTGTGGTCA 3240

CACAGTATCA CTACACGCAG TGGCCTGACA TGGGAGTACC AGAGTACTCC CTGCCAGTGC 3300

TGACCTTTGT GAGAAAGGCA GCCTATGCCA AGCGCCATGC AGTGGGGCCT GTTGTCGTCC 3360

ACTGCAGTGC TGGAGTTGGA AGAACAGGCA CATATATTGT GCTAGACAGT ATGTTGCAGC 3420

AGATTCAACA CGAAGGAACT GTCAACATAT TTGGCTTCTT AAAACACATC CGTTCACAAA 3480

GAAATTATTT GGTACAAACT GAGGAGCAAT ATGTCTTCAT TCATGATACA CTGGTTGAGG 3540

CCATACTTAG TAAAGAAACT GAGGTGCTGG ACAGTCATAT TCATGCCTAT GTTAATGCAC 3600

TCCTCATTCC TGGACCAGCA GGCAAAACAA AGCTAGAGAA ACAATTCCAG CTCCTGAGCC 3660

AGTCAAATAT ACAGCAGAGT GACTATTCTG CAGCCCTAAA GCAATGCAAC AGGGAAAAGA 3720

ATCGAACTTC TTCTATCATC CCTGTGGAAA GATCAAGGGT TGGCATTTCA TCCCTGAGTG 3780

GAGAAGGCAC AGACTACATC AATGCCTCCT ATATCATGGG CTATTACCAG AGCAATGAAT 3840

TCATCATTAC CCAGCACCCT CTCCTTCATA CCATCAAGGA TTTCTGGAGG ATGATATGGG 3900

ACCATAATGC CCAACTGGTG GTTATGATTC CTGATGGCCA AAACATGGCA GAAGATGAAT 3960

TTGTTTACTG GCCAAATAAA GATGAGCCTA TAAATTGTGA GAGCTTTAAG GTCACTCTTA 4020

TGGCTGAAGA ACACAAATGT CTATCTAATG AGGAAAAACT TATAATTCAG GACTTTATCT 4080

TAGAAGCTAC ACAGGATGAT TATGTACTTG AAGTGAGGCA CTTTCAGTGT CCTAAATGGC 4140

CAAATCCAGA TAGCCCCATT AGTAAAACTT TTGAACTTAT AAGTGTTATA AAAGAAGAAG 4200

CTGCCAATAG GGATGGGCCT ATG TTGTTC ATGATGAGCA TGGAGGAGTG ACGGCAGGAA 4260

CTTTCTGTGC TCTGACAACC CTTATGCACC AACTAGAAAA AGAAAATTCC GTGGATGTTT 4320

ACCAGGTAGC CAAGATGATC AATCTGATGA GGCCAGGAGT CTTTGCTGAC ATTGAGCAGT 4380

ATCAGTTTCT CTACAAAGTG ATCCTCAGCC TTGTGAGCAC AAGGCAGGAA GAGAATCCAT 4440

CCACCTCTCT GGACAGTAAT GGTGCAGCAT TGCCTGATGG AAATATAGCT GAGAGCTTAG 4500

AGTCTTTAGT TTAACACAGA AAGGGGTGGG GGGACTCACA TCTGAGCATT GTTTTCCTCT 4560

TCCTAAAATT AGGCAGGAAA ATCAGTCTAG TTCTGTTATC TGTTGATTTC CCATCACCTG 4620

ACAGTAACTT TCATGACATA GGATTCTGCC GCCAAATTTA TATCATTAAC AATGTGTGCC 4680

TTTTTGCAAG ACTTGTAATT TACTTATTAT GTTTGAACTA AAATGATTGA ATTTTACAGT 4740

ATTTCTAAGA ATGGAATTGT GGTATTTTTT TCTGTATTGA TTTTAACAGA AAATTTCAAT 4800

TTATAGAGGT TAGGAATTCC AAACTACAGA AAATGTTTGT TTTTAGTGTC AAATTTTTAG 4860

CTGTATTTGT AGCAATTATC AGGTTTGCTA GAAATATAAC TTTTAATACA GTAGCCTGTA 4920

AATAAAACAC TCTTCCATAT GATATTCAAC ATTTTACAAC TGCAGTATTC ACCTAAAGTA 4980

GAAATAATCT GTTACTTATT GTAAATACTG CCCTAGTGTC TCCATGGACC AAATTTATAT 5040

TTATAATTGT AGATTTTTAT ATTTTACTAC TGAGTCAAGT TTTCTAGTTC TGTGTAATTG 5100

TTTAGTTTAA TGACGTAGTT CATTAGCTGG TCTTACTCTA CCAGTTTTCT GACATTGTAT 5160 TGTGTTACCT AAGTCATTAA CTTTGTTTCA GCATGTAATT TTAACTTTTG TGGAAAATAG 5220

AAATACCTTC ATTTTGAAAG AAGTTTTTAT GAGAATAACA CCTTACCAAA CATTGTTCAA 5280

ATGGTTTTTA TCCAAGGAAT TGCAAAAATA AATATAAATA TTGCCATTAA AAAAAAAAAA 5340 AAAAAAAAAA AAAAAAAAAA AAA

Seq ID NO: 186 Protein sequence: Protein Accession ft: EOS sequence

11 21 31 41 51

I I I I

MVFKASKITF HWGKCNMSSD GSEHSLEGQK FPLEMQIYCF DADRFSSFEE A 1VKGKGKLRA 60 LSILFEVGTE ENLDFKAIID GVESVSRFGK QAALDPFILL NLLPNSTDKY YIYNGSLTSP 120 PCTDTVDWIV FKDTVSISES QLAVFCEVLT MQQSGYVMLM DYLQNNFREQ QYKFSRQVFS 180 SYTGKEEIHE AVCSSEPENV QADPENYTSL LVTWERPRW YDTMIEKFAV LYQQLDGEDQ 240 TKHEFLTDGY QDLGAILNNL LPNMSYVLQI VAICTNGLYG KYSDQLIVDM PTDNPELDLF 300 PELIGTEEII KEEEEGKDIE EGAIVNPGRD SATNQIRKKE PQISTTTHYN RIGTKYNEAK 360 TNRSPTRGSE FSGKGDVPNT SLNSTSQPVT KLATEKDISL TSQTVTELPP HTVEGTSASL 420 NDGSKTVLRS PHMNLSGTAE SLNTVSITEY EEESLLTSFK LDTGAEDSSG SSPATSAIPF 480 ISENISQGYI FSSENPETIT YDVLIPESAR NASEDSTSSG SEESLKDPSM EGNVWFPSST 540 DITAQPDVGS GRESFLQTNY TEIRVDESEK TTKSFSAGPV MSQGPSVTDL EMPHYSTFAY 600 FPTEVTPHAF TPSSRQQDLV STVNWYSQT TQPVYNEASN SSHESRIGLA EGLESEKKAV 660 IPLVIVSALT FICLWLVGI LIYWRKCFQT AHFYLEDSTS PRVISTPPTP IFPISDDVGA 720 IPIKHFPKHV ADLHASSGFT EEFETLKEFY QEVQSCTVDL GITADSSNHP DNKHKNRYIN 780 IVAYDHSRVK LAQLAEKDGK LTDYINANYV DGYNRPKAYI AAQGPLKSTA EDFWRMIWEH 840 NVEVIVMITN LVEKGRRKCD QYWPADGSEE YGNFLVTQKS VQVLAYYTVR NFTLRNTKIK 900 KGSQKGRPSG RWTQYHYTQ WPDMGVPEYS LPVLTFVRKA AYAKRHAVGP VWHCSAGVG 960 RTGTYIVLDS MLQQIQHEGT VNIFGFLKHI RSQRNYLVQT EEQYVFIHDT LVEAILSKET 1020 EVLDSHIHAY VNALLIPGPA GKTKLEKQFQ LLSQSNIQQS DYSAALKQCN REKNRTSSII 1080 PVERSRVGIS SLSGEGTDYI NASYIMGYYQ SNEFIITQHP LLHTIKDFWR MIWDHNAQLV 1140 VMIPDGQNMA EDEFVYWPNK DEPINCESFK VTLMAEEHKC LSNEEKLIIQ DFILEATQDD 1200 YVLEVRHFQC PKWPNPDSPI SKTFELISVI KEEAANRDGP MIVHDEHGGV TAGTFCALTT 1260 LMHQLEKENS VDVYQVAKMI NLMRPGVFAD IEQYQFLYKV ILSLVSTRQE ENPSTSLDSN 1320 GAALPDGNIA ESLESLV

Seq ID NO: 187 DNA sequence

Nucleic Acid Accession ft: EOS sequence

Coding sequence: 148-4632

11 21 31 41 51

I I I I

CACACATACG CACGCACGAT CTCACTTCGA TCTATACACT GGAGGATTAA AACAAACAAA 60 CAAAAAAAAC ATTTCCTTCG CTCCCCCTCC CTCTCCACTC TGAGAAGCAG AGGAGCCGCA 120 CGGCGAGGGG CCGCAGACCG TCTGGAAATG CGAATCCTAA AACGTTTCCT CGCTTGCATT 180 CAGCTCCTCT GTGTTTGCCG CCTGGATTGG GCTAATGGAT ACTACAGACA ACAGAGAAAA 240 CTTGTTGAAG AGATTGGCTG GTCCTATACA GGAGCACTGA ATCAAAAAAA TTGGGGAAAG 300 AAATATCCAA CATGTAATAG CCCAAAACAA TCTCCTATCA ATATTGATGA AGATCTTACA 360 CAAGTAAATG TGAATCTTAA GAAACTTAAA TTTCAGGGTT GGGATAAAAC ATCATTGGAA 420 AACACATTCA TTCATAACAC TGGGAAAACA GTGGAAATTA ATCTCACTAA TGACTACCGT 480 GTCAGCGGAG GAGTTTCAGA AATGGTGTTT AAAGCAAGCA AGATAACTTT TCACTGGGGA 540 AAATGCAATA TGTCATCTGA TGGATCAGAG CATAGTTTAG AAGGACAAAA ATTTCCACTT 600 GAGATGCAAA TCTACTGCTT TGATGCGGAC CGATTTTCAA GTTTTGAGGA AGCAGTCAAA 660 GGAAAAGGGA AGTTAAGAGC TTTATCCATT TTGTTTGAGG TTGGGACAGA AGAAAATTTG 720 GATTTCAAAG CGATTATTGA TGGAGTCGAA AGTGTTAGTC GTTTTGGGAA GCAGGCTGCT 780 TTAGATCCAT TCATACTGTT GAACCTTCTG CCAAACTCAA CTGACAAGTA TTACATTTAC 840 AATGGCTCAT TGACATCTCC TCCCTGCACA GACACAGTTG ACTGGATTGT TTTTAAAGAT 900 ACAGTTAGCA TCTCTGAAAG CCAGTTGGCT GTTTTTTGTG AAGTTCTTAC AATGCAACAA 960 TCTGGTTATG TCATGCTGAT GGACTACTTA CAAAACAATT TTCGAGAGCA ACAGTACAAG 1020 TTCTCTAGAC AGGTGTTTTC CTCATACACT GGAAAGGAAG AGATTCATGA AGCAGTTTGT 1080 AGTTCAGAAC CAGAAAATGT TCAGGCTGAC CCAGAGAATT ATACCAGCCT TCTTGTTACA 1140 TGGGAAAGAC CTCGAGTCGT TTATGATACC ATGATTGAGA AGTTTGCAGT TTTGTACCAG 1200 CAGTTGGATG GAGAGGACCA AACCAAGCAT GAATTTTTGA CAGATGGCTA TCAAGACTTG 1260 GGTGCTATTC TCAATAATTT GCTACCCAAT ATGAGTTATG TTCTTCAGAT AGTAGCCATA 1320 TGCACTAATG GCTTATATGG AAAATACAGC GACCAACTGA TTGTCGACAT GCCTACTGAT 1380 AATCCTGAAC TTGATCTTTT CCCTGAATTA ATTGGAACTG AAGAAATAAT CAAGGAGGAG 1440 GAAGAGGGAA AAGACATTGA AGAAGGCGCT ATTGTGAATC CTGGTAGAGA CAGTGCTACA 1500 AACCAAATCA GGAAAAAGGA ACCCCAGATT TCTACCACAA CACACTACAA TCGCATAGGG 1560 ACGAAATACA ATGAAGCCAA GACTAACCGA TCCCCAACAA GAGGAAGTGA ATTCTCTGGA 1620 AAGGGTGATG TTCCCAATAC ATCTTTAAAT TCCACTTCCC AACCAGTCAC TAAATTAGCC 1680 ACAGAAAAAG ATATTTCCTT GACTTCTCAG ACTGTGACTG AACTGCCACC TCACACTGTG 1740 GAAGGTACTT CAGCCTCTTT AAATGATGGC TCTAAAACTG TTCTTAGATC TCCACATATG 1800 AACTTGTCGG GGACTGCAGA ATCCTTAAAT ACAGTTTCTA TAACAGAATA TGAGGAGGAG 1860 AGTTTATTGA CCAGTTTCAA GCTTGATACT GGAGCTGAAG ATTCTTCAGG CTCCAGTCCC 1920 GCAACTTCTG CTATCCCATT CATCTCTGAG AACATATCCC AAGGGTATAT ATTTTCCTCC 1980 GAAAACCCAG AGACAATAAC ATATGATGTC CTTATACCAG AATCTGCTAG AAATGCTTCC 2040 GAAGATTCAA CTTCATCAGG TTCAGAAGAA TCACTAAAGG ATCCTTCTAT GGAGGGAAAT 2100 GTGTGGTTTC CTAGCTCTAC AGACATAACA GCACAGGCCG ATGTTGGATC AGGCAGAGAG 2160 AGCTTTCTCC AGACTAATTA CACTGAGATA CGTGTTGATG AATCTGAGAA GACAACCAAG 2220 TCCTTTTCTG CAGGCCCAGT GATGTCACAG GGTCCCTCAG TTACAGATCT GGAAATGCCA 2280 CATTATTCTA CCTTTGCCTA CTTCCCAACT GAGGTAACAC CTCATGCTTT TACCCCATCC 2340 TCCAGACAAC AGGATTTGGT CTCCACGGTC AACGTGGTAT ACTCGCAGAC AACCCAACCG 2400 GTATACAATG AGGCCAGTAA TAGTAGCCAT GAGTCTCGTA TTGGTCTAGC TGAGGGGTTG 2460 GAATCCGAGA AGAAGGCAGT TATACCCCTT GTGATCGTGT CAGCCCTGAC TTTTATCTGT 2520 CTAGTGGTTC TTGTGGGTAT TCTCATCTAC TGGAGGAAAT GCTTCCAGAC TGCACACTTT 2580 TACTTAGAGG ACAGTACATC CCCTAGAGTT ATATCCACAC CTCCAACACC TATCTTTCCA 2640 ATTTCAGATG ATGTCGGAGC AATTCCAATA AAGCACTTTC CAAAGCATGT TGCAGATTTA 2700 CATGCAAGTA GTGGGTTTAC TGAAGAATTT GAGACACTGA AAGAGTTTTA CCAGGAAGTG 2760 CAGAGCTGTA CTGTTGACTT AGGTATTACA GCAGACAGCT CCAACCACCC AGACAACAAG 2820 CACAAGAATC GATACATAAA TATCGTTGCC TATGATCATA GCAGGGTTAA GCTAGCACAG 2880

CTTGCTGAAA AGGATGGCAA ACTGACTGAT TATATCAATG CCAATTATGT TGATGGCTAC 2940

AACAGACCAA AAGCTTATAT TGCTGCCCAA GGCCCACTGA AATCCACAGC TGAAGATTTC 3000

TGGAGAATGA TATGGGAACA TAATGTGGAA GTTATTGTCA TGATAACAAA CCTCGTGGAG 3060

AAAGGAAGGA GAAAATGTGA TCAGTACTGG CCTGCCGATG GGAGTGAGGA GTACGGGAAC 3120

TTTCTGGTCA CTCAGAAGAG TGTGCAAGTG CTTGCCTATT ATACTGTGAG GAATTTTACT 3180

CTAAGAAACA CAAAAATAAA AAAGGGCTCC CAGAAAGGAA GACCCAGTGG ACGTGTGGTC 3240

ACACAGTATC ACTACACGCA GTGGCCTGAC ATGGGAGTAC CAGAGTACTC CCTGCCAGTG 3300

CTGACCTTTG TGAGAAAGGC AGCCTATGCC AAGCGCCATG CAGTGGGGCC TGTTGTCGTC 3360

10 CACTGCAGTG CTGGAGTTGG AAGAACAGGC ACATATATTG TGCTAGACAG TATGTTGCAG 3420

CAGATTCAAC ACGAAGGAAC TGTCAACATA TTTGGCTTCT TAAAACACAT CCGTTCACAA 3480

AGAAATTATT TGGTACAAAC TGAGGAGCAA TATGTCTTCA TTCATGATAC ACTGGTTGAG 3540

GCCATACTTA GTAAAGAAAC TGAGGTGCTG GACAGTCATA TTCATGCCTA TGTTAATGCA 3600

CTCCTCATTC CTGGACCAGC AGGCAAAACA AAGCTAGAGA AACAATTCCA GGGTCTCACT 3660

15 CTGTCACCCA GGCTGGAGTG CAGAGGCACA ATCTCGGCTC ACTGCAACCT TCCTCTCCCT 3720

GGCTTAACTG ATCCTCCTAC CTCAGCCTCC CGAGTGGCTG GGACTATACT CCTGAGCCAG 3780

TCAAATATAC AGCAGAGTGA CTATTCTGCA GCCCTAAAGC AATGCAACAG GGAAAAGAAT 3840

CGAACTTCTT CTATCATCCC TGTGGAAAGA TCAAGGGTTG GCATTTCATC CCTGAGTGGA 3900

GAAGGCACAG ACTACATCAA TGCCTCCTAT ATCATGGGCT ATTACCAGAG CAATGAATTC 3960

20 ATCATTACCC AGCACCCTCT CCTTCATACC ATCAAGGATT TCTGGAGGAT GATATGGGAC 4020

CATAATGCCC AACTGGTGGT TATGATTCCT GATGGCCAAA ACATGGCAGA AGATGAATTT 4080

GTTTACTGGC CAAATAAAGA TGAGCCTATA AATTGTGAGA GCTTTAAGGT CACTCTTATG 4140

GCTGAAGAAC ACAAATGTCT ATCTAATGAG GAAAAACTTA TAATTCAGGA CTTTATCTTA 4200

GAAGCTACAC AGGATGATTA TGTACTTGAA GTGAGGCACT TTCAGTGTCC TAAATGGCCA 4260

25 AATCCAGATA GCCCCATTAG TAAAACTTTT GAACTTATAA GTGTTATAAA AGAAGAAGCT 4320

GCCAATAGGG ATGGGCCTAT GATTGTTCAT GATGAGCATG GAGGAGTGAC GGCAGGAACT 4380

TTCTGTGCTC TGACAACCCT TATGCACCAA CTAGAAAAAG AAAATTCCGT GGATGTTTAC 4440

CAGGTAGCCA AGATGATCAA TCTGATGAGG CCAGGAGTCT TTGCTGACAT TGAGCAGTAT 4500

CAGTTTCTCT ACAAAGTGAT CCTCAGCCTT GTGGGCACAA GGCAGGAAGA GAATCCATCC 4560

30 ACCTCTCTGG ACAGTAATGG TGCAGCATTG CCTGATGGAA ATATAGCTGA GAGCTTAGAG 4620

TCTTTAGTTT AACACAGAAA GGGGTGGGGG GACTCACATC TGAGCATTGT TTTCCTCTTC 4680

CTAAAATTAG GCAGGAAAAT CAGTCTAGTT CTGTTATCTG TTGATTTCCC ATCACCTGAC 4740

AGTAACTTTC ATGACATAGG ATTCTGCCGC CAAATTTATA TCATTAACAA TGTGTGCCTT 4800

TTTGCAAGAC TTGTAATTTA CTTATTATGT TTGAACTAAA ATGATTGAAT TTTACAGTAT 4860

35 TTCTAAGAAT GGAATTGTGG TATTTTTTTC TGTATTGATT TTAACAGAAA ATTTGAATTT 4920

ATAGAGGTTA GGAATTCCAA ACTACAGAAA ATGTTTGTTT TTAGTGTCAA ATTTTTAGCT 4980

GTATTTGTAG CAATTATCAG GTTTGCTAGA AATATAACTT TTAATACAGT AGCCTGTAAA 5040

TAAAACACTC TTCCATATGA TATTCAACAT TTTACAACTG CAGTATTCAC CTAAAGTAGA 5100

AATAATCTGT TACTTATTGT AAATACTGCC CTAGTGTCTC CATGGACCAA ATTTATATTT 5160

40 ATAATTGTAG ATTTTTATAT TTTACTACTG AGTCAAGTTT TCTAGTTCTG TGTAATTGTT 5220

TAGTTTAATG ACGTAGTTCA TTAGCTGGTC TTACTCTACC AGTTTTCTGA CATTGTATTG 5280

TGTTACCTAA GTCATTAACT TTGTTTCAGC ATGTAATTTT AACTTTTGTG GAAAATAGAA 5340

ATACCTTCAT TTTGAAAGAA GTTTTTATGA GAATAACACC TTACCAAACA TTGTTCAAAT 5400

GGTTTTTATC CAAGGAATTG CAAAAATAAA TATAAATATT GCCATTAAAA AAAAAAAAAA 5460

45 AAAAAAAAAA AAAAAAAAAA A

Seq ID NO. 188 Protein sequence: Protein Accession ft: EOS sequence

50 11 21 31 41 51

I

MRILKRFLAC IQLLCVCRLD WANGYYRQQR KLVEEIGWSY T IGALNQKNWG KKYPTCNSPK 60 QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 120 FKASKITFHW GKCNMSSDGS EHSLEGQKFP LEMQIYCPDA DRFSSFEEAV KGKGKLRALS 180

55 ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 240 TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 300 TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPRWYD TMIEKFAVLY QQLDGEDQTK 360 HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY SDQ IVDMPT DNPELDLFPE 420 LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 480

60 RSPTRGSEFS GKGDVPNTSL NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND 540 GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS 600 ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG NVWFPSSTDI 660 TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 720 TEVTPHAFTP SSRQQDLVST VNWYSQTTQ PVYNEASNSS HESRIGLAEG LESEKKAVIP 780

65 LVIVSALTFI CLWLVGILI YWRKCFQTAH FYLEDSTSPR VISTPPTPIF PISDDVGAIP 840 IKHFPKHVAD LHASSGFTEE FETLKEFYQE VQSCTVDLGI TADSSNHPDN KHKNRYINIV 900 AYDHSRVKLA QLAEKDGKLT DYINANYVDG YNRPKAYIAA QGPLKSTAED FWRMIWEHNV 960 .EVIVMITNLV EKGRRKCDQY WPADGSEEYG NFLVTQKSVQ VLAYYTVRNF TLRNTKIKKG 1020 ^'SQKGRPSGRV VTQYHYTQWP DMGVPEYSLP VLTFVRKAAY AKRHAVGPW VHCSAGVGRT 1080

70 GTYIVLDSML QQIQHEGTVN IFGFLKHIRS QRNYLVQTEΞ QYVFIHDTLV EAILSKETEV 1140 LDSHIHAYVN ALLIPGPAGK TKLEKQFQGL TLSPRLECRG TISAHCNLPL PGLTDPPTSA 1200 SRVAGTILLS QSNIQQSDYS AALKQCNREK NRTSSIIPVE RSRVGISSLS GEGTDYINAS 1260 YIMGYYQSNE FIITQHPLLH TIKDFWRMIW DHNAQLWMI PDGQNMAEDE FVYWPNKDEP 1320 INCESFKVTL MAEEHKCLSN EEKLIIQDFI LEATQDDYVL EVRHFQCPKW PNPDSPISKT 1380

75 FELISVIKEE AANRDGPMIV HDEHGGVTAG TFCALTTLMH QLEKENSVDV YQVAKMINLM 1440 RPGVFADIEQ YQFLYKVILS LVGTRQEENP STSLDSNGAA LPDGNIAESL ESLV

Seq ID NO- 189 DNA sequence oϋ Nucleic Acid Accession ft: NM_002820 Coding sequence: 304..831

11 21 31 41 51 or I I l I I I

O CCGGTTCGCA AAGAAGCTGA CTTCAGAGGG GGAAACTTTC TTCTTTTAGG AGGCGGTTAG 60

CCCTGTTCCA CGAACCCAGG AGAACTGCTG GCCAGATTAA TTAGACATTG CTATGGGAGA 120

CGTGTAAACA CACTACTTAT CATTGATGCA TATATAAAAC CATTTTATTT TCGCTATTAT 180 TTCAGAGGAA GCGCCTCTGA TTTGTTTCTT TTTTCCCTTT TTGCTCTTTC TGGCTGTGTG 240

GTTTGGAGAA AGCACAGTTG GAGTAGCCGG TTGCTAAATA AGTCCCGAGC GCGAGCGGAG 300

ACGATGCAGC GGAGACTGGT TCAGCAGTGG AGCGTCGCGG TGTTCCTGCT GAGCTACGCG 360

GTGCCCTCCT GCGGGCGCTC GGTGGAGGGT CTCAGCCGCC GCCTCAAAAG AGCTGTGTCT 420

GAACATCAGC TCCTCCATGA CAAGGGGAAG TCCATCCAAG ATTTACGGCG ACGATTCTTC 480

CTTCACCATC TGATCGCAGA AATCCACACA GCTGAAATCA GAGCTACCTC GGAGGTGTCC 540

CCTAACTCCA AGCCCTCTCC CAACACAAAG AACCACCCCG TCCGATTTGG GTCTGATGAT 600

GAGGGCAGAT ACCTAACTCA GGAAACTAAC AAGGTGGAGA CGTACAAAGA GCAGCCGCTC 660

AAGACACCTG GGAAGAAAAA GAAAGGCAAG CCCGGGAAAC GCAAGGAGCA GGAAAAGAAA 720

10 AAACGGCGAA CTCGCTCTGC CTGGTTAGAC TCTGGAGTGA CTGGGAGTGG GCTAGAAGGG 780

GACCACCTGT CTGACACCTC CACAACGTCG CTGGAGCTCG ATTCACGGTA ACAGGCTTCT 840

CTGGCCCGTA GCCTCAGCGG GGTGCTCTCA GCTGGGTTTT GGAGCCTCCC TTCTGCCTTG 900

GCTTGGACAA ACCTAGAATT TTCTCCCTTT ATGTATCTCT ATCGATTGTG TAGCAATTGA 960

CAGAGAATAA CTCAGAATAT TGTCTGCCTT AAAGCAGTAC CCCCCTACCA CACACACCCC 1020

15 TGTCCTCCAG CACCATAGAG AGGCGCTAGA GCCCATTCCT CTTTCTCCAC CGTCACCCAA 1080

CATCAATCCT TTACCACTCT ACCAAATAAT TTCATATTCA AGCTTCAGAA GCTAGTGACC 1140

ATCTTCATAA TTTGCTGGAG AAGTGTATTT CTTCCCCTTA CTCTCACACC TGGGCAAACT 1200

TTCTTCAGTG TTTTTCATTT CTTACGTTCT TTCACTTCAA GGGAGAATAT AGAAGCATTT 1260

GATATTATCT ACAAACACTG CAGAACAGCA TCATGTCATA AACGATTCTG AGCCATTCAC 1320

20 ACTTTTTATT TAATTAAATG TATTTAATTA AATCTCAAAT TTATTTTAAT GTAAAGAACT 1380

TAAATTATGT TTTAAACACA TGCCTTAAAT TTGTTTAATT AAATTTAACT CTGGTTTCTA 1440

CCAGCTCATA CAAAATAAAT GGTTTCTGAA AATGTTTAAG TATTAACTTA CAAGGATATA 1500

GGTTTTTCTC ATGTATCTTT TTGTTCATTG GCAAGATGAA ATAATTTTTC TAGGGTAATG 1560 CCGTAGGAAA AATAAAACTT CACATTTAAA AAAAA

25

Seq ID NO: 190 Protein sequence: Protein Accession ft: NP_002811

30

1 11 21 31 41 51

I I I I I I

MQRRLVQQWS VAVFLLSYAV PSCGRSVEGL SRRLKRAVSE HQLLHDKGKS IQDLRRRFFL 60

HHLIAEIHTA EIRATSEVSP NSKPSPNTKN HPVRFGSDDE GRYLTQETNK VETYKEQPLK 120

35 TPGKKKKGKP GKRKEQEKKK RRTRSAWLDS GVTGSGLEGD HLSDTSTTSL ELDSR

Seq ID NO: 191 DNA sequence Nucleic Acid Accession ft: XM_059328 Coding sequence: 52..1023

40

1 11 21 31 41 51

I I I I I I

GGGCTGTCCG GCCCACTCCC CTGGGAGCGC GAGCGGTGGA CCCAGGCGGC CATGTCCCGC 60

CCTCGCATGC GCCTGGTGGT CACCGCGGAC GACTTTGGTT ACTGCCCGCG ACGCGATGAG 120

45 GGTATCGTGG AGGCCTTTCT GGCCGGGGCT GTGACCAGCG TGTCCCTGCT GGTCAACGGT 180

GCGGCCACGG AGAGCGCGGC GGAGCTGGCC CGCAGGCACA GCATCCCCAC GGGCCTCCAC 240

GCCAACCTGT CCGAGGGCCG CCCCGTGGGT CCGGCCCGCC GTGGCGCCTC ATCGCTGCTC 300

GGCCCGGAAG GCTTCTTCCT TGGCAAGATG GGATTCCGGG AGGCGGTGGC GGCCGGAGAC 360

GTGGATTTGC CTCAGGTGCG GGAGGAGCTC GAGGCCCAAC TAAGCTGCTT CCGGGAGCTG 420

50 CTGGGCAGGG CCCCCACGCA CGCGGACGGG CACCAGCACG TGCACGTGCT CCCAGGCGTG 480

TGCCAGGTGT TCGCCGAGGC GCTGCAGGCC TATGGGGTGC GCTTTACGCG ACTGCCGCTG 540

GAGCGCGGTG TGGGTGGCTG CACTTGGCTG GAGGCCCCCG CGCGTGCCTT CGCCTGCGCC 600

GTGGAGCGCG ACGCCCGGGC CGCCGTGGGC CCCTTCTCCC GCCACGGCCT GCGGTGGACA 660

GACGCCTTCG TGGGCCTGAG CACTTGCGGC CGGCACATGT CCGCTCACCG CGTGTCCGGG 720

55 GCCCTGGCGC GGGTCCTGGA AGGTACCCTA GCGGGCCACA CCCTGACAGC CGAGCTGATG 780

GCGCACCCCG GCTACCCCAG TGTGCCTCCC ACCGGCGGCT GCGGTGAAGG CCCCGACGCT 840

TTCTCTTGCT CTTGGGAGCG GCTGCATGAG CTGCGCGTCC TCACCGCGCC CACGCTGCGG 900

GCCCAGCTTG CCCAGGATGG CGTGCAGCTT TGCGCCCTCG ACGACCTGGA CTCCAAGAGG 960

CCAGGGGAGG AGGTCCCCTG TGAGCCCACT CTGGAACCCT TCCTGGAACC CTCCCTACTC 1020

60 TGACCCCCTA CAGACAACCA AGCACTAATC CCCTTAGTAC CAAGAAAGGG GAGCCAGGAT 1080

TTAGTCCTGG CCCAGCCCAG AGCTGGGACC TGGAGCACGA TCTGTTGACT TCCCTGGGTA 1140

GGACACTGCC ACCTCTGGGC TCAGGTCCTC ATGCCTCCAA ATGGCATCTA GAGTTTGAGC 1200

AGCCTTCTTG GCTGCAGGCA GGCCTAGCCT GTGGCAGCGG GCTAGGGCCC GCAGAGCATT 1260

TGGTGCCCCT CCATGTTGCA ATGCAAACAC CTTCACCACT GGGGCAGTGG GGAGAGATGG 1320

65 CTATATTAAT AAAATAACGT GTGTCTTTC

Seq ID NO: 192 Protein sequence: Protein Accession ft: XP 059328

70

51

MSRPRMRLW TADDFGYCPR RDEGIVEAFL AGAVTSVSLL VNGAATESAA ELARRHSIPT 60

GLHANLSEGR PVGPARRGAS SLLGPEGFFL GKMGFREAVA AGDVDLPQVR EELEAQLSCF 120

75 RELLGRAPTH ADGHQHVHVL PGVCQVFAEA LQAYGVRFTR LPLERGVGGC TWLEAPARAF 180

ACAVERDARA AVGPFSRHGL RWTDAFVGLS TCGRHMSAHR VSGALARVLE GTLAGHTLTA 240

ELMAHPGYP.S VPPTGGCGEG PDAFSCSWER LHELRVLTAP TLRAQLAQDG VQLCALDDLD 300 SKRPGEEVPC EPTLEPFLEP SLL

80 Seq ID NO: 193 DNA sequence

Nucleic Acid Accession ft: NM_005688.1 Coding sequence: 126..4439

__ 1 11 21 31 41 51

85 i i i i i i

CCGGGCAGGT GGCTCATGCT CGGGAGCGTG GTTGAGCGGC TGGCGCGGTT GTCCTGGAGC 60 AGGGGCGCAG GAATTCTGAT GTGAAACTAA CAGTCTGTGA GCCCTGGAAC CTCCGCTCAG 120 AGAAGATGAA GGATATCGAC ATAGGAAAAG AGTATATCAT CCCCAGTCCT GGGTATAGAA 180

GTGTGAGGGA GAGAACCAGC ACTTCTGGGA CGCACAGAGA CCGTGAAGAT TCCAAGTTCA 240

GGAGAACTCG ACCGTTGGAA TGCCAAGATG CCTTGGAAAC AGCAGCCCGA GCCGAGGGCC 300

TCTCTCTTGA TGCCTCCATG CATTCTCAGC TCAGAATCCT GGATGAGGAG CATCCCAAGG 360

GAAAGTACCA TCATGGCTTG AGTGCTCTGA AGCCCATCCG GACTACTTCC AAACACCAGC 420

ACCCAGTGGA CAATGCTGGG CTTTTTTCCT GTATGACTTT TTCGTGGCTT TCTTCTCTGG 480

CCCGTGTGGC CCACAAGAAG GGGGAGCTCT CAATGGAAGA CGTGTGGTCT CTGTCCAAGC 540

ACGAGTCTTC TGACGTGAAC TGCAGAAGAC TAGAGAGACT GTGGCAAGAA GAGCTGAATG 600

AAGTTGGGCC AGACGCTGCT TCCCTGCGAA GGGTTGTGTG GATCTTCTGC CGCACCAGGC 660

TCATCCTGTC CATCGTGTGC CTGATGATCA CGCAGCTGGC TGGCTTCAGT GGACCAGCCT 720

TCATGGTGAA ACACCTCTTG GAGTATACCC AGGCAACAGA GTCTAACCTG CAGTACAGCT 780

TGTTGTTAGT GCTGGGCCTC CTCCTGACGG AAATCGTGCG GTCTTGGTCG CTTGCACTGA 840

CTTGGGCATT GAATTACCGA ACCGGTGTCC GCTTGCGGGG GGCCATCCTA ACCATGGCAT 900

TTAAGAAGAT CCTTAAGTTA AAGAACATTA AAGAGAAATC CCTGGGTGAG CTCATCAACA 960

TTTGCTCCAA CGATGGGCAG AGAATGTTTG AGGCAGCAGC CGTTGGCAGC CTGCTGGCTG 1020

GAGGACCCGT TGTTGCCATC TTAGGCATGA TTTATAATGT AATTATTCTG GGACCAACAG 1080

GCTTCCTGGG ATCAGCTGTT TTTATCCTCT TTTACCCAGC AATGATGTTT GCATCACGGC 1140

TCACAGCATA TTTCAGGAGA AAATGCGTGG CCGCCACGGA TGAACGTGTC CAGAAGATGA 1200

ATGAAGTTCT TACTTACATT AAATTTATCA AAATGTATGC CTGGGTCAAA GCATTTTCTC 1260

AGAGTGTTCA AAAAATCCGC GAGGAGGAGC GTCGGATATT GGAAAAAGCC GGGTACTTCC 1320

AGGGTATCAC TGTGGGTGTG GCTCCCATTG TGGTGGTGAT TGCCAGCGTG GTGACCTTCT 1380

CTGTTCATAT GACCCTGGGC TTCGATCTGA CAGCAGCACA GGCTTTCACA GTGGTGACAG 1440

TCTTCAATTC CATGACTTTT GCTTTGAAAG TAACACCGTT TTCAGTAAAG TCCCTCTCAG 1500

AAGCCTCAGT GGCTGTTGAC AGATTTAAGA GTTTGTTTCT AATGGAAGAG GTTCACATGA 1560

TAAAGAACAA ACCAGCCAGT CCTCACATCA AGATAGAGAT GAAAAATGCC ACCTTGGCAT 1620

GGGACTCCTC CCACTCCAGT ATCCAGAACT CGCCCAAGCT GACCCCCAAA ATGAAAAAAG 1680

ACAAGAGGGC TTCCAGGGGC AAGAAAGAGA AGGTGAGGCA GCTGCAGCGC ACTGAGCATC 1740

AGGCGGTGCT GGCAGAGCAG AAAGGCCACC TCCTCCTGGA CAGTGACGAG CGGCCCAGTC 1800

CCGAAGAGGA AGAAGGCAAG CACATCCACC TGGGCCACCT GCGCTTACAG AGGACACTGC 1860

ACAGCATCGA TCTGGAGATC CAAGAGGGTA AACTGGTTGG AATCTGCGGC AGTGTGGGAA 1920

GTGGAAAAAC CTCTCTCATT TCAGCCATTT TAGGCCAGAT GACGCTTCTA GAGGGCAGCA 1980

TTGCAATCAG TGGAACCTTC GCTTATGTGG CCCAGCAGGC CTGGATCCTC AATGCTACTC 2040

TGAGAGACAA CATCCTGTTT GGGAAGGAAT ATGATGAAGA AAGATACAAC TCTGTGCTGA 2100

ACAGCTGCTG CCTGAGGCCT GACCTGGCCA TTCTTCCCAG CAGCGACCTG ACGGAGATTG 2160

GAGAGCGAGG AGCCAACCTG AGCGGTGGGC AGCGCCAGAG GATCAGCCTT GCCCGGGCCT 2220

TGTATAGTGA CAGGAGCATC TACATCCTGG ACGACCCCCT CAGTGCCTTA GATGCCCATG 2280

TGGGCAACCA CATCTTCAAT AGTGCTATCC GGAAACATCT CAAGTCCAAG ACAGTTCTGT 2340

TTGTTACCCA CCAGTTACAG TACCTGGTTG ACTGTGATGA AGTGATCTTC ATGAAAGAGG 2400

GCTGTATTAC GGAAAGAGGC ACCCATGAGG AACTGATGAA TTTAAATGGT GACTATGCTA 2460

CCATTTTTAA TAACCTGTTG CTGGGAGAGA CACCGCCAGT TGAGATCAAT TCAAAAAAGG 2520

AAACCAGTGG TTCACAGAAG AAGTCACAAG ACAAGGGTCC TAAAACAGGA TCAGTAAAGA 2580

AGGAAAAAGC AGTAAAGCCA GAGGAAGGGC AGCTTGTGCA GCTGGAAGAG AAAGGGCAGG 2640

GTTCAGTGCC CTGGTCAGTA TATGGTGTCT ACATCCAGGC TGCTGGGGGC CCCTTGGCAT 2700

TCCTGGTTAT TATGGCCCTT TTCATGCTGA ATGTAGGCAG CACCGCCTTC AGCACCTGGT 2760

GGTTGAGTTA CTGGATCAAG CAAGGAAGCG GGAACACCAC TGTGACTCGA GGGAACGAGA 2820

CCTCGGTGAG TGACAGCATG AAGGACAATC CTCATATGCA GTACTATGCC AGCATCTACG 2880

CCCTCTCCAT GGCAGTCATG CTGATCCTGA AAGCCATTCG AGGAGTTGTC TTTGTCAAGG 2940

GCACGCTGCG AGCTTCCTCC CGGCTGCATG ACGAGCTTTT CCGAAGGATC CTTCGAAGCC 3000

CTATGAAGTT TTTTGACACG ACCCCCACAG GGAGGATTCT CAACAGGTTT TCCAAAGACA 3060

TGGATGAAGT TGACGTGCGG CTGCCGTTCC AGGCCGAGAT GTTCATCCAG AACGTTATCC 3120

TGGTGTTCTT CTGTGTGGGA ATGATCGCAG GAGTCTTCCC GTGGTTCCTT GTGGCAGTGG 3180

GGCCCCTTGT CATCCTCTTT TCAGTCCTGC ACATTGTCTC CAGGGTCCTG ATTCGGGAGC 3240

TGAAGCGTCT GGACAATATC ACGCAGTCAC CTTTCCTCTC CCACATCACG TCCAGCATAC 3300

AGGGCCTTGC CACCATCCAC GCCTACAATA AAGGGCAGGA GTTTCTGCAC AGATACCAGG 3360

AGCTGCTGGA TGACAACCAA GCTCCTTTTT TTTTGTTTAC GTGTGCGATG CGGTGGCTGG 3420

CTGTGCGGCT GGACCTCATC AGCATCGCCC TCATCACCAC CACGGGGCTG ATGATCGTTC 3480

TTATGCACGG GCAGATTCCC CCAGCCTATG CGGGTCTCGC CATCTCTTAT GCTGTCCAGT 3540

TAACGGGGCT GTTCCAGTTT ACGGTCAGAC TGGCATCTGA GACAGAAGCT CGATTCACCT 3600

CGGTGGAGAG GATCAATCAC TACATTAAGA CTCTGTCCTT GGAAGCACCT GCCAGAATTA 3660

AGAACAAGGC TCCCTCCCCT GACTGGCCCC AGGAGGGAGA GGTGACCTTT GAGAACGCAG 3720

AGATGAGGTA CCGAGAAAAC CTCCCTCTTG TCCTAAAGAA AGTATCCTTC ACGATCAAAC" 3780

CTAAAGAGAA GATTGGCATT GTGGGGCGGA CAGGATCAGG GAAGTCCTCG CTGGGGATGG 3840

CCCTCTTCCG TCTGGTGGAG TTATCTGGAG GCTGCATCAA GATTGATGGA GTGAGAATCA 3900

GTGATATTGG CCTTGCCGAC CTCCGAAGCA AACTCTCTAT CATTCCTCAA GAGCCGGTGC 3960

TGTTCAGTGG CACTGTCAGA TCAAATTTGG ACCCCTTCAA CCAGTACACT GAAGACCAGA 4020

TTTGGGATGC CCTGGAGAGG ACACACATGA AAGAATGTAT TGCTCAGCTA CCTCTGAAAC 4080

TTGAATCTGA AGTGATGGAG AATGGGGATA ACTTCTCAGT GGGGGAACGG CAGCTCTTGT 4140

GCATAGCTAG AGCCCTGCTC CGCCACTGTA AGATTCTGAT TTTAGATGAA GCCACAGCTG 4200

CCATGGACAC AGAGACAGAC TTATTGATTC AAGAGACCAT CCGAGAAGCA TTTGCAGACT 4260

GTACCATGCT GACCATTGCC CATCGCCTGC ACACGGTTCT AGGCTCCGAT AGGATTATGG 4320

TGCTGGCCCA GGGACAGGTG GTGGAGTTTG ACACCCCATC GGTCCTTCTG TCCAACGACA 4380

GTTCCCGATT CTATGCCATG TTTGCTGCTG CAGAGAACAA GGTCGCTGTC AAGGGCTGAC 4440

TCCTCCCTGT TGACGAAGTC TCTTTTCTTT AGAGCATTGC CATTCCCTGC CTGGGGCGGG 4500

CCCCTCATCG CGTCCTCCTA CCGAAACCTT GCCTTTCTCG ATTTTATCTT TCGCACAGCA 4560

GTTCCGGATT GGCTTGTGTG TTTCACTTTT AGGGAGAGTC ATATTTTGAT TATTGTATTT 4620

ATTCCATATT CATGTAAACA AAATTTAGTT TTTGTTCTTA ATTGCACTCT AAAAGGTTCA 4680

GGGAACCGTT ATTATAATTG TATCAGAGGC CTATAATGAA GCTTTATACG TGTAGCTATA 4740

TCTATATATA ATTCTGTACA TAGCCTATAT TTACAGTGAA AATGTAAGCT GTTTATTTTA 4800

TATTAAAATA AGCACTGTGC TAATAACAGT GCATATTCCT TTCTATCATT TTTGTACAGT 4860

TTGCTGTACT AGAGATCTGG TTTTGCTATT AGACTGTAGG AAGAGTAGCA TTTCATTCTT 4920

CTCTAGCTGG TGGTTTCACG GTGCCAGGTT TTCTGGGTGT CCAAAGGAAG ACGTGTGGCA 4980

ATAGTGGGCC CTCCGACAGC CCCCTCTGCC GCCTCCCCAC AGCCGCTCCA GGGGTGGCTG 5040

GAGACGGGTG GGCGGCTGGA GACCATGCAG AGCGCCGTGA GTTCTCAGGG CTCCTGCCTT 5100

CTGTCCTGGT GTCACTTACT GTTTCTGTCA GGAGAGCAGC GGGGCGAAGC CCAGGCCCCT 5160

TTTCACTCCC TCCATCAAGA ATGGGGATCA CAGAGACATT CCTCCGAGCC GGGGAGTTTC 5220

TTTCCTGCCT TCTTCTTTTT GCTGTTGTTT CTAAACAAGA ATCAGTCTAT CCACAGAGAG 5280

TCCCACTGCC TCAGGTTCCT ATGGCTGGCC ACTGCACAGA GCTCTCCAGC TCCAAGACCT 5340 GTTGGTTCCA AGCCCTGGAG CCAACTGCTG CTTTTTGAGG TGGCACTTTT TCATTTGCCT 5400

ATTCCCACAC CTCCACAGTT CAGTGGCAGG GCTCAGGATT TCGTGGGTCT GTTTTCCTTT 5460

CTCACCGCAG TCGTCGCACA GTCTCTCTCT CTCTCTCCCC TCAAAGTCTG CAACTTTAAG 5520

CAGCTCTTGC TAATCAGTGT CTCACACTGG CGTAGAAGTT TTTGTACTGT AAAGAGACCT 5580

ACCTCAGGTT GCTGGTTGCT GTGTGGTTTG GTGTGTTCCC GCAAACCCCC TTTGTGCTGT 5640

GGGGCTGGTA GCTCAGGTGG GCGTGGTCAC TGCTGTCATC AGTTGAATGG TCAGCGTTGC 5700

ATGTCGTGAC CAACTAGACA TTCTGTCGCC TTAGCATGTT TGCTGAACAC CTTGTGGAAG 5760

CAAAAATCTG AAAATGTGAA TAAAATTATT TTGGATTTTG TAAAAAAAAA AAAAAAAAAA 5820 AAAAAAAAAA AAAAAAAA

Seq ID NO: 194 Protein sequence: Protein Accession ft: NP_005679.1

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I I I I

MKDIDIGKEY IIPSPGYRSV R 1ERTSTSGTH RDREDSKFRR TRPLECQDAL ETAARAEGLS 60 LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP VDNAGLFSCM TFSWLSSLAR 120 VAHKKGELSM EDVWSLSKHE SSDVNCRRLE RLWQEELNEV GPDAASLRRV VWIFCRTRLI 180 LSIVCLMITQ LAGFSGPAFM VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW 240 ALNYRTGVRL RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 300 PWAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA TDERVQKMNE 360 VLTYIKFIKM YAWVKAFSQS VQKIREEERR I EKAGYFQG ITVGVAPI VIASWTFSV 420 HMTLGFDLTA AQAFTWTVF NSMTFALKVT PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK 480 NKPASPHIKI EMKNATLAWD SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA 540 VLAEQKGHLL LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG 600 KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD EERYNSVLNS 660 CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY SDRSIYILDD PLSALDAHVG 720 NHIFNSAIRK HLKSKTVLFV THQLQYLVDC DEVIFMKEGC ITERGTHEEL MNLNGDYATI 780 FNNLLLGETP PVEINSKKET SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS 840 VPWSVYGVYI QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS 900 VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGWFVKGT LRASSRLHDE LFRRILRSPM 960 KFFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV FFCVGMIAGV FPWFLVAVGP 1020 LVILFSVLHI VSRVLIRELK RLDNITQSPF LSHITSSIQG LATIHAYNKG QEFLHRYQEL 1080 LDDNQAPFFL FTCAMRWLAV RLDLISIALI TTTGLMIVLM HGQIPPAYAG LAISYAVQLT 1140 GLFQFTVRLA SETEARFTSV ERINHYIKTL SLEAPARIKN KAPSPDWPQE GEVTFENAEM 1200 RYRENLPLVL KKVSFTIKPK EKIGIVGRTG SGKSSLGMAL FRLVELSGGC IKIDGVRISD 1260 IGLADLRSKL SIIPQEPVLF SGTVRSNLDP FNQYTEDQIW DALERTHMKE CIAQLPLKLE 1320 SEVMENGDNF SVGERQLLCI ARALLRHCKI I DEATAAM DTETDLLIQE TIREAFADCT 1380 MLTIAHRLHT VLGSDRIMVL AQGQWEFDT PSVLLSNDSS RFYAMFAAAE NKVAVKG

Seq ID NO: 195 DNA sequence Nucleic Acid Accession ft: NM_006470 Coding sequence: 228..1922

11 21 31 41 51

I I I I

GCTGTCCTGA GCCTGAGTAC TCTAGCTGCC TTGTCGCCAT CGCATCTGGC T 1GCCATCCAG 60 CGCCAGCACA CAGTAATGAG TGGCCGAGCT TCCTCTGGGA GGGAGGAAAC AGTTAAAATC 120 TTGCAGCAGC TGCAATCATC TAGGCGTGGT TCTCTTGTCT GACTTGGGCT GCACAGATCC 180 TGGGCCAAGG GACAGAAGAA AGACAGCCTA GGAGCAGAGC CTCCCAGATG GCTGAGTTGG 240 ATCTAATGGC TCCAGGGCCA CTGCCCAGGG CCACTGCTCA GCCCCCAGCC CCTCTCAGCC 300 CAGACTCTGG GTCACCCAGC CCAGATTCTG GGTCAGCCAG CCCAGTGGAA GAAGAGGACG 360 TGGGCTCCTC GGAGAAGCTT GGCAGGGAGA CGGAGGAACA GGACAGCGAC TCTGCAGAGC 420 AGGGGGATCC TGCTGGTGAG GGGAAAGAGG TCCTGTGTGA CTTCTGCCTT GATGACACCA 480 GAAGAGTGAA GGCAGTGAAG TCCTGTCTAA CCTGCATGGT GAATTACTGT GAAGAGCACT 540 TGCAGCCGCA TCAGGTGAAC ATCAAACTGC AAAGCCACCT GCTGACCGAG CCAGTGAAGG 600 ACCACAACTG GCGATACTGC CCTGCCCACC ACAGCCCACT GTCTGCTTTC TGCTGCCCTG 660 ATCAGCAGTG CATCTGCCAG GACTGTTGCC AGGAGCACAG TGGCCACACC ATAGTCTCCC 720 TGGATGCAGC CCGCAGGGAC AAGGAGGCTG AACTCCAGTG CACCCAGTTA GACTTGGAGC 780 GGAAACTCAA GTTGAATGAA AATGCCATCT CCAGGCTCCA GGCTAACCAA AAGTCTGTTC 840 TGGTGTCGGT GTCAGAGGTC AAAGCGGTGG CTGAAATGCA GTTTGGGGAA CTCCTTGCTG 900 CTGTGAGGAA GGCCCAGGCC AATGTGATGC TCTTCTTAGA GGAGAAGGAG CAAGCTGCGC 960 TGAGCCAGGC CAACGGTATC AAGGCCCACC TGGAGTACAG GAGTGCCGAG ATGGAGAAGA 1020 GCAAGCAGGA GCTGGAGAGG ATGGCGGCCA TCAGCAACAC TGTCCAGTTC TTGGAGGAGT 1080 ACTGCAAGTT TAAGAACACT GAAGACATCA CCTTCCCTAG TGTTTACGTA GGGCTGAAGG 1140 ATAAACTCTC GGGCATCCGC AAAGTTATCA CGGAATCCAC TGTACACTTA ATCCAGTTGC 1200 TGGAGAACTA TAAGAAAAAG CTCCAGGAGT TTTCCAAGGA AGAGGAGTAT GACATCAGAA 1260 CTCAAGTGTC TGCCGTTGTT CAGCGCAAAT ATTGGACTTC CAAACCTGAG CCCAGCACCA 1320 GGGAACAGTT CCTCCAATAT GCGTATGACA TCACGTTTGA CCCGGACACA GCACACAAGT 1380 ATCTCCGGCT GCAGGAGGAG AACCGCAAGG TCACCAACAC CACGCCCTGG GAGCATCCCT 1440 ACCCGGACCT CCCCAGCAGG TTCCTGCACT GGCGGCAGGT GCTGTCCCAG CAGAGTCTGT 1500 ACCTGCACAG GTACTATTTT GAGGTGGAGA TCTTCGGGGC AGGCACCTAT GTTGGCCTGA 1560 CCTGCAAAGG CATCGACCGG AAAGGGGAGG AGCGCAACAG TTGCATTTCC GGAAACAACT 1620 TCTCCTGGAG CCTCCAATGG AACGGGAAGG AGTTCACGGC CTGGTACAGT GACATGGAGA 1680 CCCCACTCAA AGCTGGCCCT TTCCGGAGGC TCGGGGTCTA TATCGACTTC CCGGGAGGGA 1740 TCCTTTCCTT CTATGGCGTA GAGTATGATA CCATGACTCT GGTTCACAAG TTTGCCTGCA 1800 AATTTTCAGA ACCAGTCTAT GCTGCCTTCT GGCTTTCCAA GAAGGAAAAC GCCATCCGGA 1860 TTGTAGATCT GGGAGAGGAA CCCGAGAAGC CAGCACCGTC CTTGGGGGTG ACTGCTCCCT 1920 AGACTCCAGG AGCCATATCC CAGACCTTTG CCAGCTACAG TGATGGGATT TGCATTTTAG 1980 GGTGATTTGT GGGCAGAAAT AACTGCTGAT GGTAGCTGGC TTTTGAAATC CTATGGGGTC 2040 TCTGAATGAA AACATTCTCC AGCTGCTCTC TTTTGCTCCA TATGGTGCTG TTCTCTATGT 2100 GTTTGCAGTA ATTCTTTTTT TTTTTTTTGA GACGGAGTCT CGCACTGTTG CCCAGGCTGG 2160 AGAGCAGTGG CGCGATCTTG GCTCACTGCA AGCTCCGCCT CCCGAGTTCA AGCAATTCTC 2220 CTGCCTCAGC CTCCCGAGTA GCTGGGATTA CAGGTGCCTG CCAGCACACC CAGCTAATGT 2280 TTTGTATTTT TAGTAGAGAT GGGGTTTCAC CATGTTGGCC AGGCAGATCT CAAACTCCTG 2340 ACCTCGTGAT GCACCCACCT CGGCCTCCCA AAGTGCTGGG ATTACATGCG TGAGCCACTG 2400

CGCCCTGCCT GTTTGTAGTA ATTTTTAGGC ACCAAATCTC CCTCATCTTC TAGTGCCATT 2460

CTCCTCTCTG TTCAGGTAAA TGTCACACTG TGCCCAGAAT GGATGACCAG GAACCTTAAA 2520 GAGTGGCTGA AAAGATTGCA GAGTTATCAT AATAAATTGC TAACTTGCGT

Seq ID NO: 196 Protein sequence: Protein Accession ft: NP_006461

1 11 21 31 41 51

M IAELDLMAPG PILPRATAQPP AIPLSPDSGSP SIPDSGSASPV EIEEDVGSSEK LIGRETEEQDS 60

DSAEQGDPAG EGKEVLCDFC LDDTRRVKAV KSCLTCMVNY CEEHLQPHQV NIKLQSHLLT 120

EPVKDHNWRY CPAHHSPLSA FCCPDQQCIC QDCCQEHSGH TIVSLDAARR DKEAELQCTQ 180

LDLERKLKLN ENAISRLQAN QKSVLVSVSE VKAVAEMQFG ELLAAVRKAQ ANVMLFLEEK 240

EQAALSQANG IKAHLEYRSA EMEKSKQELE RMAAISNTVQ FLEEYCKFKN TEDITFPSVY 300

VGLKDKLSGI RKVITESTVH LIQLLENYKK KLQEFSKEEE YDIRTQVSAV VQRKYWTSKP 360

EPSTREQFLQ YAYDITFDPD TAHKYLRLQE ENRKVTNTTP WEHPYPDLPS RFLHWRQVLS 420

QQSLYLHRYY FEVEIFGAGT YVGLTCKGID RKGEERNSCI SGNNFSWSLQ WNGKEFTAWY 480

SDMETPLKAG PFRRLGVYID FPGGILSFYG VEYDTMTLVH KFACKFSEPV YAAFWLSKKE 540 NAIRIVDLGE EPEKPAPSLG VTAP

Seq ID NO: 197 DNA sequence Nucleic Acid Accession ft: NM_004316 Coding sequence: 433-1149

1 - 11 21 31 41 51

I I I I I I

CCCGAGACCC GGCGCAAGAG AGCGCAGCCT TAGTAGGAGA GGAACGCGAG ACGCGGCAGA 60

GCGCGTTCAG CACTGACTTT TGCTGCTGCT TCTGCTTTTT TTTTTCTTAG AAACAAGAAG 120

GCGCCAGCGG CAGCCTCACA CGCGAGCGCC ACGCGAGGCT CCCGAAGCCA ACCCGCGAAG 180

GGAGGAGGGG AGGGAGGAGG AGGCGGCGTG CAGGGAGGAG AAAAAGCATT TTCACCTTTT 240

TTGCTCCCAC TCTAAGAAGT CTCCCGGGGA TTTTGTATAT ATTTTTTAAC TTCCGTCAGG 300

GCTCCCGCTT CATATTTCCT TTTCTTTCCC TCTCTGTTCC TGCACCCAAG TTCTCTCTGT 360

GTCCCCCTCG CGGGCCCCGC ACCTCGCGTC CCGGATCGCT CTGATTCCGC GACTCCTTGG 420

CCGCCGCTGC GCATGGAAAG CTCTGCCAAG ATGGAGAGCG GCGGCGCCGG CCAGCAGCCC 480

CAGCCGCAGC CCCAGCAGCC CTTCCTGCCG CCCGCAGCCT GTTTCTTTGC CACGGCCGCA 540

GCCGCGGCGG CCGCAGCCGC CGCAGCGGCA GCGCAGAGCG CGCAGCAGCA GCAGCAGCAG 600

CAGCAGCAGC AGCAGCAGCA GCAGGCGCCG CAGCTGAGAC CGGCGGCCGA CGGCCAGCCC 660

TCAGGGGGCG GTCACAAGTC AGCGCCCAAG CAAGTCAAGC GACAGCGCTC GTCTTCGCCC 720

GAACTGATGC GCTGCAAACG CCGGCTCAAC TTCAGCGGCT TTGGCTACAG CCTGCCGCAG 780

CAGCAGCCGG CCGCCGTGGC GCGCCGCAAC GAGCGCGAGC GCAACCGCGT CAAGTTGGTC 840

AACCTGGGCT TTGCCACCCT TCGGGAGCAC GTCCCCAACG GCGCGGCCAA CAAGAAGATG 900

AGTAAGGTGG AGACACTGCG CTCGGCGGTC GAGTACATCC GCGCGCTGCA GCAGCTGCTG 960

GACGAGCATG ACGCGGTGAG CGCCGCCTTC CAGGCAGGCG TCCTGTCGCC CACCATCTCC 1020

CCCAACTACT CCAΛCGACTT GAACTCCATG GCCGGCTCGC CGGTCTCATC CTACTCGTCG 1080

GACGAGGGCT CTTACGACCC GCTCAGCCCC GAGGAGCAGG AGCTTCTCGA CTTCACCAAC 1140

TGGTTCTGAG GGGCTCGGCC TGGTCAGGCC CTGGTGCGAA TGGACTTTGG AAGCAGGGTG 1200

ATCGCACAAC CTGCATCTTT AGTGCTTTCT TGTCAGTGGC GTTGGGAGGG GGAGAAAAGG 1260

AAAAGAAAAA AAAAGAAGAA GAAGAAGAAA AGAGAAGAAG AAAAAAACGA AAACAGTCAA 1320

CCAACCCCAT CGCCAACTAA GCGAGGCATG CCTGAGAGAC ATGGCTTTCA GAAAACGGGA 1380

AGCGCTCAGA ACAGTATCTT TGCACTCCAA TCATTCACGG AGATATGAAG AGCAACTGGG 1440

ACCTGAGTCA ATGCGCAAAA TGCAGCTTGT GTGCAAAAGC AGTGGGCTCC TGGCAGAAGG 1500

GAGCAGCACA CGCGTTATAG TAACTCCCAT CACCTCTAAC ACGCACAGCT GAAAGTTCTT 1560

GCTCGGGTCC CTTCACCTCC CCGCCCTTTC TTAGAGTGCA GTTCTTAGCC CTGTAGAAAC 1620 GAGTTGGTGT CTTTC

Seq ID NO: 198 Protein sequence: Protein Accession ft: NP_004307

1 11 21 31 41 51

M IESSAKMESG GIAGQQPQPQP QIQPFLPPAAC FIFATAAAAAA AIAAAAAAQSA QIQQQQQQQQQ 60

QQQQAPQLRP AADGQPSGGG HKSAPKQVKR QRSSSPELMR CKRRLNFSGF GYSLPQQQPA 120

AVARRNERER NRVKLVNLGF ATLREHVPNG AANKKMSKVE TLRSAVEYIR ALQQLLDEHD 180 AVSAAFQAGV LSPTISPNYS NDLNSMAGSP VSSYSSDEGS YDPLSPEEQE LLDFTNWF

Seq ID NO: 199 DNA sequence Nucleic Acid Accession ft: NM 007015

Coding sequence: 1-1005

1 11 21 31 41 51

I I I I I I

ATGACAGAGA ACTCCGACAA AGTTCCCATT GCCCTGGTGG GACCTGATGA CGTGGAATTC 60

TGCAGCCCCC CGGCGTACGC TACGCTGACG GTGAAGCCCT CCAGCCCCGC GCGGCTGCTC 120

AAGGTGGGAG CCGTGGTCCT CATTTCGGGA GCTGTGCTGC TGCTCTTTGG GGCCATCGGG 180

GCCTTCTACT TCTGGAAGGG GAGCGACAGT CACATTTACA ATGTCCATTA CACCATGAGT 240

ATCAATGGGA AACTACAAGA TGGGTCAATG GAAATAGACG CTGGGAACAA CTTGGAGACC 300

TTTAAAATGG GAAGTGGAGC TGAAGAAGCA ATTGCAGTTA ATGATTTCCA GAATGGCATC 360

ACAGGAATTC GTTTTGCTGG AGGAGAGAAG TGCTACATTA AAGCGCAAGT GAAGGCTCGT 420

ATTCCTGAGG TGGGCGCCGT GACCAAACAG AGCATCTCCT CCAAACTGGA AGGCAAGATC 480

ATGCCAGTCA AATATGAAGA AAATTCTCTT ATCTGGGTGG CTGTAGATCA GCCTGTGAAG 540

GACAACAGCT TCTTGAGTTC TAAGGTGTTA GAACTCTGCG GTGACCTTCC TATTTTCTGG 600

CTTAAACCAA CCTATCCAAA AGAAATCCAG AGGGAAAGAA GAGAAGTGGT AAGAAAAATT 660

GTTCCAACTA CCACAAAAAG ACCACACAGT GGACCACGGA GCAACCCAGG CGCTGGAAGA 720

CTGAATAATG AAACCAGACC CAGTGTTCAA GAGGACTCAC AAGCCTTCAA TCCTGATAAT 780 CCTTATCATC AGCAGGAAGG GGAAAGCATG ACATTCGACC CTAGACTGGA TCACGAAGGA 840 ATCTGTTGTA TAGAATGTAG GCGGAGCTAC ACCCACTGCC AGAAGATCTG TGAACCCCTG 900 GGGGGCTATT ACCCATGGCC TTATAATTAT CAAGGCTGCC GTTCGGCCTG CAGAGTCATC 960 ATGCCATGTA GCTGGTGGGT GGCCCGTATC TTGGGCATGG TGTGAAATCA CTTCATATAT 1020 CACGTGCTGT AAAATAAGAA CTAGCTGAAG AGACAACCAA AGAAGCATTA AGGCAGGTTG 1080 ATGCTGATGG GACCATAAAA TATTTTTACA CGCAGCCTGA GCGGTTATTC TTGACACTCT 1140 TAACAGAATT TTTTTAATCG TTTTCCAGAA CTTTAGTATA TGCAAATGCA CTGAAAGGGT 1200 AGTTCAAGTC TAAAATGCCA TAACCCCGTT ATTTGTTATT TTTTATTTGC ATTGATTTGC 1260 CATAAGTCTT CCCTTGCTTG CATCTTCCAA AGCTATTTCG AAATAAACAC GAAAATTTAC 1320 AGTTTGCC

Seq ID NO: 200 Protein sequence: Protein Accession ft: NP 008946

11 21 31 41 51

MTENSDKVPI ALVGPDDVEF CSPPAYATLT VKPSSPARLL KVGAWLISG AVLLLFGAIG 60 AFYFWKGSDS HIYNVHYTMS INGKLQDGSM EIDAGNNLET FKMGSGAEEA lAVNDFQNGI 120 TGIRFAGGEK CYIKAQVKAR IPEVGAVTKQ SISSKLEGKI MPVKYEENSL IWVAVDQPVK 180 DNSFLSSKVL ELCGDLPIFW LKPTYPKEIQ RERREWRKI VPTTTKRPHS GPRSNPGAGR 240 LNNETRPSVQ EDSQAFNPDN PYHQQEGESM TFDPRLDHEG ICCIECRRSY THCQKICEPL 300 GGYYPWPYNY QGCRSACRVI MPCSWWVARI LGMV

Seq ID NO: 201 DNA sequence

Nucleic Acid Accession ft: NM_000728.2

Coding sequence: 112..495

11 21 31 41 51

I I I

GTAATAAGAG C IGGGGTCTCC GCGGGGAAGG CGCCCACAGC AGGTGTGGTG TTCATCCCGG 60 GTCGACCGGC CGCTCGCGCT GCCCTGAAAC TCTAGTCGCC AGAGAGGCGG CATGGGTTTC 120 CGGAAGTTCT CCCCCTTCCT GGCTCTCAGT ATCTTGGTCC TGTACCAGGC GGGCAGCCTC 180 CAGGCGGCGC CATTCAGGTC TGCCCTGGAG AGCAGCCCAG ACCCGGCCAC ACTCAGTAAA 240 GAGGACGCGC GCCTCCTGCT GGCTGCACTG GTGCAGGACT ATGTGCAGAT GAAGGCCAGT 300 GAGCTGAAGC AGGAGCAGGA GACACAGGGC TCCAGCTCCG CTGCCCAGAA GAGAGCCTGC 360 AACACTGCCA CCTGTGTGAC TCATCGGCTG GCAGGCTTGC TGAGCAGATC AGGGGGCATG 420 GTGAAGAGCA ACTTCGTGCC CACCAATGTG GGTTCCAAAG CCTTTGGCAG GCGCCGCAGG 480 GACCTTCAAG CCTGAGCAGA TGAATGACTC CAGGAAGAAG GTGTGTCCTA AATCCAATGA 540 CATATCCTTA TAAGAGATTC ACTCAGAAGA CACATGTGGA GAAGGTGACA TGACAGAGGC 600 AAGGAGGCAC AAGCCAAGGA AGTCTGTGTC TACCAGAAGC CAGAATCACA GAACAGTCTC 660 TGGAAGAAGA GCAGCCCTGC TGACACCTAG AGTTTGGACT TCCAGCTTCC AGAACTGTGA 720 GAGAATAATT TCTGTTGTTT TAAGCCACAA AGTTTGTGGT AATTTGTTAT GACAGCCCTA 780 GGAAACTAAT ACAATACATT TTCATTTATT TTGGGTAAAT GCCTTGGAGT GGGATTGCTG 840 GGTTATTTGG AAAGTGTGTA TTTAACTCTG TAAGAAACTG CCAAACTATT TTCTGAAGTG 900 ACTGTACCAC TTCGCCTTCT TGCCAGCCAC ATATGAGAGC TCTAGTATTT CCACAAATAG 960 GTATGTAGCA GTATCTCATT GCTGTTTTAA TTTGTATTTC CCCAATGACT AATGACGTTG 1020 AGCATCTATT TTACCATATG TTTATCACCT TTATTGAAGG GTCTGTTTAA ATCTTCTGCT 1080 AAATTTTTGT TGGCTTGCTT GCTTTATTAG TGTTGAGTTT TTAGAGCTCT TTATATGTTG 1140 TGGATGCAAG ATTGTTTTCA GATATATAGT TTGGAAACTT CCTTCCCCTG AATCTGCGGA 1200 TTGCTTTTTC ATTTTCTTAG CAGTGTCTCT CACAGAGAAA AAGTTGTAAT TTGAATAAGA 1260 TCCAATTCAT CTTTTTTTTT CTTTTATGTA TTGTGCTTTT AGTTCATGTC TAAGAACTCT 1320 TTGCCTAACT AAGGTCCCAA GGTCACAATA ACCTTATTCT ATACTTTCTT GTAAAAGTTT 1380 TATAGTTTTA TATTTTATAT GTAGATTAGT GATCTATTTT GAGTTAATTT TTGTATAAGG 1440 TGAGAGGTGT AGGTTGAAAT TCATACCTGT GAATATAGAT ACCCAATTGT TTCAGTGCCA 1500 TTTGTTAAAA AGACTGTTAT TTCACCATTT AATTGCCCCT GCACCTTTGT CAAAAAGCAA 1560 CTGATCATAT TTGTGTGGGT ATATTTCTGG GTTCTCAATT CTGTCTCATT GATTGATTTG 1620 ACCATTCTTT TGCCAATGTC ATACTGCCTT GATTAGTGTA GTGTTAAAGT GAATCTCAAA 1680 ACCAGATAAT GTGGGTCTAC CAACATTGTT CATTCTTGTT CAAAAAGATT TTAGCTACAT 1740 CTAAAATATT TTCTACATCT TTTATACATT TTAGAATCAG TGTGTTACTA TCTACAAAAT 1800 TTCTGATGAG ATTTTTAATG GGATTGTGTT AAATCAGTGG GTTAATTTTG GGAGAATTAG 1860 CATATTAATA ATATTAAGTC GTTCAATTCA TGAACACAAT ACATGTTTTC ACTTATTTAG 1920 GTTTTCTCTG TTTAACAGTG TTCTCAGTTT TCAACAGAAA TATTCTACAC 1980 ATATCTTGTT AGATTTTTAA CTATTTTATT TTTTGGTGCT AATGTAAATG GTACTTAAAC 2040 ATTTTTGTTT TTAATTGTTC ATTGCTAGTA GATAGAAATA CAATATTTAA AATATTAGGA 2100 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA

Seq ID NO: 202 Protein sequence: Protein Accession ft: NP_000719.1

1 11 21 31 41 51

1 I I I I I

MGFRKFSPFL ALSILVLYQA GSLQAAPFRS ALESSPDPAT LSKEDARLLL AALVQDYVQM 60 KASELKQEQE TQGSSSAAQK RACNTATCVT HRLAGLLSRS GGMVKSNFVP TNVGSKAFGR 120 RRRDLQA

Seq ID NO: 203 DNA sequence Nucleic Acid Accession ft: NM_001741 Coding sequence: 71.. 96

11 21 31 41 51

CTCTGGCTGG ACGCCGCCGC CGCCGCTGCC ACCGCCTCTG ATCCAAGCCA CCTCCCGCCA 60

GAGAGGTGTC ATGGGCTTCC AAAAGTTCTC CCCCTTCCTG GCTCTCAGCA TCTTGGTCCT 120 GTTGCAGGCA GGCAGCCTCC ATGCAGCACC ATTCAGGTCT GCCCTGGAGA GCAGCCCAGC 180

AGACCCGGCC ACGCTCAGTG AGGACGAAGC GCGCCTCCTG CTGGCTGCAC TGGTGCAGGA 240

CTATGTGCAG ATGAAGGCCA GTGAGCTGGA GCAGGAGCAA GAGAGAGAGG GCTCCAGCCT 300 GGACAGCCCC AGATCTAAGC GGTGCGGTAA TCTGAGTACT TGCATGCTGG GCACATACAC 360

GCAGGACTTC AACAAGTTTC ACACGTTCCC CCAAACTGCA ATTGGGGTTG GAGCACCTGG 420

AAAGAAAAGG GATATGTCCA GCGACTTGGA GAGAGACCAT CGCCCTCATG TTAGCATGCC 480

CCAGAATGCC AACTAAACTC CTCCCTTTCC TTCCTAATTT CCCTTCTTGC ATCCTTCCTA 540

TAACTTGATG CATGTGGTTT GGTTCCTCTC TGGTGGCTCT TTGGGCTGGT ATTGGTGGCT 600

TTCCTTGTGG CAGAGGATGT CTCAAACTTC AGATGGGAGG AAAGAGAGCA GGACTCACAG 660

GTTGGAAGAG AATCACCTGG GAAAATACCA GAAAATGAGG GCCGCTTTGA GTCCCCCAGA 720

GATGTCATCA GAGCTCCTCT GTCCTGCTTC TGAATGTGCT GATCATTTGA GGAATAAAAT 780 TATTTTTCCC C

Seq ID NO: 204 Protein sequence: Protein Accession ft: NP_001732

1 11 21 31 41 51

I I I I I I

MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL LAALVQDYVQ 60 MKASELEQEQ EREGSSLDSP RSKRCGNLST CMLGTYTQDF NKFHTFPQTA IGVGAPGKKR 120 DMSSDLERDH RPHVSMPQNA N

Seq ID NO: 205 DNA sequence Nucleic Acid Accession ft: NM_005361 Coding sequence: 1-945

11 21 31 41 51

I I I I I I

ATGCCTCTTG AGCAGAGGAG TCAGCACTGC AAGCCTGAAG AAGGCCTTGA GGCCCGAGGA 60

GAGGCCCTGG GCCTGGTGGG TGCGCAGGCT CCTGCTACTG AGGAGCAGCA GACCGCTTCT 120

TCCTCTTCTA CTCTAGTGGA AGTTACCCTG GGGGAGGTGC CTGCTGCCGA CTCACCGAGT 180 CCTCCCCACA GTCCTCAGGG AGCCTCCAGC TTCTCGACTA CCATCAACTA CACTCTTTGG 240

AGACAATCCG ATGAGGGCTC CAGCAACCAA GAAGAGGAGG GGCCAAGAAT GTTTCCCGAC 300

CTGGAGTCCG AGTTCCAAGC AGCAATCAGT AGGAAGATGG TTGAGTTGGT TCATTTTCTG 360

CTCCTCAAGT ATCGAGCCAG GGAGCCGGTC ACAAAGGCAG AAATGCTGGA GAGTGTCCTC 420

AGAAATTGCC AGGACTTCTT TCCCGTGATC TTCAGCAAAG CCTCCGAGTA CTTGCAGCTG 480 GTCTTTGGCA TCGAGGTGGT GGAAGTGGTC CCCATCAGCC ACTTGTACAT CCTTGTCACC 540

TGCCTGGGCC TCTCCTACGA TGGCCTGCTG GGCGACAATC AGGTCATGCC CAAGACAGGC 600

CTCCTGATAA TCGTCCTGGC CATAATCGCA ATAGAGGGCG ACTGTGCCCC TGAGGAGAAA 660

ATCTGGGAGG AGCTGAGTAT GTTGGAGGTG TTTGAGGGGA GGGAGGACAG TGTCTTCGCA 720

CATCCCAGGA AGCTGCTCAT GCAAGATCTG GTGCAGGAAA ACTACCTGGA GTACCGGCAG 780 GTGCCCGGCA GTGATCCTGC ATGCTACGAG TTCCTGTGGG GTCCAAGGGC CCTCATTGAA 840

ACCAGCTATG TGAAAGTCCT GCACCATACA CTAAAGATCG GTGGAGAACC TCACATTTCC 900 TACCCACCCC TGCATGAACG GGCTTTGAGA GAGGGAGAAG AGTGA

Seq ID NO: 206 Protein sequence: Protein Accession ft: NP_005352

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MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQQTAS SSSTLVEVTL GEVPAADSPS 60 PPHSPQGASS FSTTINYTLW RQSDEGSSNQ EEEGPRMFPD LESEFQAAIS RKMVELVHFL 120

LLKYRAREPV TKAEMLESVL RNCQDFFPVI FSKASEYLQL VFGIEWEW PISHLYILVT 180

CLGLSYDGLL GDNQVMPKTG LLIIVLAIIA IEGDCAPEEK IWEELSMLEV FEGREDSVFA 240

HPRKLLMQDL VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHT LKIGGEPHIS 300 YPPLHERALR EGEE

Seq ID NO: 207 DNA sequence Nucleic Acid Accession ft: NM_021115 Coding sequence: 743-2893

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AAAGGAAGGG AGGGAGGGAG AAAGGAGAAG TTGGTTTAGA GGCCAGCCGG ACGAGCTTTG 60

GGCACCGCCC TTAGGAGGGC CACCCTCAGA GTCTGACAGC AGGTGAAGGT CCTAAATCTC 120

CCCAAACTAA CTGGTGTCTT TTCTCCTCTT CCAAGATGCT CTTCCCGAGG GAGATGCTAG 180

CCCTTTGGGT CCTTACCTCC TGCCCTCAGG AGCCCCGGAG AGAGGCAGTC CTGGCAAAGA 240

GCACCCTGAA GAGAGAGTGG TAACAGCGCC CCCCAGTTCC TCACAGTCGG CGGAAGTGCT 300

GGGCGAGCTG GTGCTGGATG GGACCGCACC CTCTGCACAT CACGACATCC CAGCCCTGTC 360

ACCGCTGCTT CCAGAGGAGG CCCGCCCCAA GCACGCCTTG CCCCCCAAGA AGAAACTGCC 420

TTCGCTCAAG CAGGTGAACT CTGCCAGGAA GCAGCTGAGG CCCAAGGCCA CCTCCGCAGC 480

CACTGTCCAA AGGGCAGGGT CCCAGCCAGC GTCCCAGGGC CTAGATCTCC TCTCCTCCTC 540

CACGGAGAAG CCTGGCCCAC CGGGGGACCC GGACCCCATC GTGGCCTCCG AGGAGGCATC 600

AGAAGTGCCC CTTTGGCTGG ACCGAAAGGA GAGTGCGGTC CCTACAACAC CCGCACCCCT 660

GCAAATCTCC CCCTTCACTT CGCAGCCCTA TGTGGCCCAC ACACTCCCCC AGAGGCCAGA 720

ACCCGGGGAG CCTGGGCCTG ACATGGCCCA GGAGGCCCCC CAGGAGGACA CCAGCCCCAT 780

GGCCCTGATG GACAAAGGTG AGAATGAGCT GACTGGGTCA GCCTCAGAGG AGAGCCAGGA 840

GACCACTACC TCCACCATTA TCACCACCAC GGTCATCACC ACCGAGCAGG CACCAGCTCT 900

CTGCAGTGTG AGCTTCTCCA ATCCTGAGGG GTACATTGAC TCCAGCGACT ACCCACTGCT 960

GCCCCTCAAC AACTTTCTGG AGTGCACATA CAACGTGACA GTCTACACTG GCTATGGGGT 1020

GGAGCTCCAG GTGAAGAGTG TGAACCTGTC CGATGGGGAA CTGCTCTCCA TCCGCGGGGT 1080

GGACGGCCCT ACCCTGACCG TCCTGGCCAA CCAGACACTC CTGGTGGAGG GGCAGGTAAT 1140

CCGAAGCCCC ACCAACACCA TCTCCGTCTA CTTCCGGACC TTCCAGGACG ACGGCCTTGG 1200

GACCTTCCAG CTTCACTACC AGGCCTTCAT GCTGAGCTGC AACTTTCCCC GCCGGCCTGA 1260

CTCTGGGGAT GTCACGGTGA TGGACCTGCA CTCAGGTGGG GTGGCCCACT TTCACTGCCA 1320

CCTGGGCTAT GAGCTCCAGG GCGCTAAGAT GCTGACATGC ATCAATGCCT CCAAGCCGCA 1380

CTGGAGCAGC CAGGAGCCCA TCTGCTCAGC TCCTTGTGGA GGGGCAGTGC ACAATGCCAC 1440

CATCGGCCGC GTCCTCTCCC CAAGTTACCC TGAAAACACA AATGGGAGCC AATTCTGCAT 1500

CTGGACGATT GAAGCTCCAG AGGGCCAGAA GCTGCACCTG CACTTTGAGA GGCTGTTGCT 1560 GCATGACAAG GACAGGATGA CGGTTCACAG CGGGCAGACC AACAAGTCAG CTCTTCTCTA 1620

CGACTCCCTT CAAACCGAGA GTGTCCCTTT TGAGGGCCTG CTGAGCGAAG GCAACACCAT 1680

CCGCATCGAG TTCACGTCCG ACCAGGCCCG GGCGGCCTCC ACCTTCAACA TCCGATTTGA 1740

AGCGTTTGAG AAAGGCCACT GCTATGAGCC CTACATCCAG AATGGGAACT TCACTACATC 1800

CGACCCGACC TATAACATTG GGACTATAGT GGAGTTCACC TGCGACCCCG GCCACTCCCT 1860

GGAGCAGGGC CCGGCCATCA TCGAATGCAT CAATGTGCGG GACCCATACT GGAATGACAC 1920

AGAGCCCCTG TGCAGAGCCA TGTGTGGTGG GGAGCTCTCT GCTGTGGCTG GGGTGGTATT 1980

GTCCCCAAAC TGGCCCGAGC CCTACGTGGA AGGTGAAGAT TGTATCTGGA AGATCCACGT 2040

GGGAGAAGAG AAACGGATCT TCTTAGATAT CCAGTTCCTG AATCTGAGCA ACAGTGACAT 2100

CTTGACCATC TACGATGGCG ACGAGGTCAT GCCCCACATC TTGGGGCAGT ACCTTGGGAA 2160

CAGTGGCCCC CAGAAACTGT ACTCCTCCAC GCCAGACTTA ACCATCCAGT TCCATTCGGA 2220

CCCTGCTGGC CTCATCTTTG GAAAGGGCCA GGGATTTATC ATGAACTACA TAGAGGTATC 2280

AAGGAATGAC TCCTGCTCGG ATTTACCCGA GATCCAGAAT GGCTGGAAAA CCACTTCTCA 2340

CACGGAGTTG GTGCGGGGAG CCAGAATCAC CTACCAGTGT GACCCCGGCT ATGACATCGT 2400

GGGGAGTGAC ACCCTCACCT GCCAGTGGGA CCTCAGCTGG AGCAGCGACC CCCCATTTTG 2460

TGAGAAAATT ATGTACTGCA CCGACCCCGG AGAGGTGGAT CACTCGACCC GCTTAATTTC 2520

GGATCCTGTG CTGCTGGTGG GGACCACCAT CCAATACACC TGCAACCCCG GTTTTGTGCT 2580

TGAAGGGAGT TCTCTTCTGA CCTGCTACAG CCGTGAAACA GGGACTCCCA TCTGGACGTC 2640

TCGCCTGCCC CACTGCGTTT CAGAAGCGGC AGCAGAGACG TCGCTGGAAG GGGGGAACAT 2700

GGCCCTGGCT ATCTTCATCC CGGTCCTCAT CATCTCCTTA CTGCTGGGAG GAGCCTACAT 2760

TTACATCACA AGATGTCGCT ACTATTCCAA CCTCCGCCTG CCTCTGATGT ACTCCCACCC 2820

CTACAGCCAG ATCACCGTGG AAACCGAGTT TGACAACCCC ATTTACGAGA CAGGGGGAAC 2880

CCAAAAGGTT TAGGGTTTCA TTTAAAAAGA GGTACCCTTT AAAAAGGGGC TTGTGAACTC 2940

AACCCCAATT TCCCCGAGAC ATTTATCCAA AGGCCCTGGG GGCCTTGATT TAAACCCCCA 3000

AAAGGCGGCT GTTTTTTGGT TAAACTTTTT AACAAAGGGT TACGGGTTTT TTCCCCGGAT 3060 TTTATAAATT TTAAAAGTG

Seq ID NO: 208 Protein sequence: Protein Accession ft: NP 066938

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MAQEAPQEDT SPMALMDKGE NELTGSASEE SQETTTSTII TTTVITTEQA PALCSVSFSN 60

PEGYIDSSDY PLLPLNNFLE CTYNVTVYTG YGVELQVKSV NLSDGELLSI RGVDGPTLTV 120

LANQTLLVEG QVIRSPTNTI SVYFRTFQDD GLGTFQLHYQ AFMLSCNFPR RPDSGDVTVM 180

DLHSGGVAHF HCHLGYELQG AKMLTCINAS KPHWSSQEPI CSAPCGGAVH NATIGRVLSP 240

SYPENTNGSQ FCIWTIEAPE GQKLHLHFER LLLHDKDRMT VHSGQTNKSA LLYDSLQTES 300

VPFEGLLSEG NTIRIEFTSD QARAASTFNI RFEAFEKGHC YEPYIQNGNF TTSDPTYNIG 360

TIVEFTCDPG HSLEQGPAII ECINVRDPYW NDTEPLCRAM CGGELSAVAG WLSPNWPEP 420

YVEGEDCIWK IHVGEEKRIP LDIQFLNLSN SDILTIYDGD EVMPHILGQY LGNSGPQKLY 480

SSTPDLTIQF HSDPAGLIFG KGQGFIMNYI EVSRNDSCSD LPEIQNGWKT TSHTELVRGA 540

RITYQCDPGY DIVGSDTLTC QWDLSWSSDP PFCEKIMYCT DPGEVDHSTR LISDPVLLVG 600

TTIQYTCNPG FVLEGSSLLT CYSRETGTPI WTSRLPHCVS EAAAETSLEG GNMALAIFIP 660 VLIISLLLGG AYIYITRCRY YSNLRLPLMY SHPYSQITVE TEFDNPIYET GGTQKV

Seq ID NO: 209 DNA sequence

Nucleic Acid Accession ft: NM_001327.1

Coding sequence: 89-631

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AGCAGGGGGC GCTGTGTGTA CCGAGAATAC GAGAATACCT CGTGGGCCCT GACCTTCTCT 60

CTGAGAGCCG GGCAGAGGCT CCGGAGCCAT GCAGGCCGAA GGCCGGGGCA CAGGGGGTTC 120

GACGGGCGAT GCTGATGGCC CAGGAGGCCC TGGCATTCCT GATGGCCCAG GGGGCAATGC 180

TGGCGGCCCA GGAGAGGCGG GTGCCACGGG CGGCAGAGGT CCCCGGGGCG CAGGGGCAGC 240

AAGGGCCTCG GGGCCGGGAG GAGGCGCCCC GCGGGGTCCG CATGGCGGCG CGGCTTCAGG 300

GCTGAATGGA TGCTGCAGAT GCGGGGCCAG GGGGCCGGAG AGCCGCCTGC TTGAGTTCTA 360

CCTCGCCATG CCTTTCGCGA CACCCATGGA AGCAGAGCTG GCCCGCAGGA GCCTGGCCCA 420

GGATGCCCCA CCGCTTCCCG TGCCAGGGGT GCTTCTGAAG GAGTTCACTG TGTCCGGCAA 480

CATACTGACT ATCCGACTGA CTGCTGCAGA CCACCGCCAA CTGCAGCTCT CCATCAGCTC 540

CTGTCTCCAG CAGCTTTCCC TGTTGATGTG GATCACGCAG TGCTTTCTGC CCGTGTTTTT 600

GGCTCAGCCT CCCTCAGGGC AGAGGCGCTA AGCCCAGCCT GGCGCCCCTT CCTAGGTCAT 660

GCCTCCTCCC CTAGGGAATG GTCCCAGCAC GAGTGGCCAG TTCATTGTGG GGGCCTGATT 720 GTTTGTCGCT GGAGGAGGAC GGCTTACATG TTTGTTTCTG TAGAAAATAA AACTGAGCTA

Seq ID NO: 210 Protein sequence: Protein Accession ft: NP_001318.1

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MQAEGRGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPGGGA 60 PRGPHGGAAS GLNGCCRCGA RGPESRLLEF YLAMPFATPM EAELARRSLA QDAPPLPVPG 120 VLLKEFTVSG NILTIRLTAA DHRQLQLSIS SCLQQLSLLM WITQCFLPVF LAQPPSGQRR

Seq ID NO: 211 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 52-459

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I I I I I I

CCTCGTGGGC CCTGACCTTC TCTCTGAGAG CCGGGCAGAG GCTCCGGAGC CATGCAGGCC 60

GAAGGCCAGG GCACAGGGGG TTCGACGGGC GATGCTGATG GCCCAGGAGG CCCTGGCATT 120

CCTGATGGCC CAGGGGGCAA TGCTGGCGGC CCAGGAGAGG CGGGTGCCAC GGGCGGCAGA 180

GGTCCCCGGG GCGCAGGGGC AGCAAGGGCC TCGGGGCCGA GAGGAGGCGC CCCGCGGGGT 240

CCGCATGGCG GTGCCGCTTC TGCGCAGGAT GGAAGGTGCC CCTGCGGGGC CAGGAGGCCG 300 GACAGCCGCC TGCTTCAGTT CCGACTGACT GCTGCAGACC ACCGCCAACT GCAGCTCTCC 360

ATCAGCTCCT GTCTCCAGCA GCTTTCCCTG TTGATGTGGA TCACGCAGTG CTTTCTGCCC 420

GTGTTTTTGG CTCAGGCTCC CTCAGGGCAG AGGCGCTAAG CCCAGCCTGG CGCCCCTTCC 480

TAGGTCATGC CTCCTCCCCT AGGGAATGGT CCCAGCACGA GTGGCCAGTT CATTGTGGGG 540

GCCTGATTGT TTGTCGCTGG AGGAGGACGG CTTACATGTT TGTTTCTGTA GAAAATAAAG 600 CTGAGCTA

Seq ID NO 212 Protein sequence Protein Accession ft Eos sequence

1 11 21 31 41 51

MQAEGQGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPRGGA 60 PRGPHGGAAS AQDGRCPCGA RRPDSRLLQF RLTAADHRQL QLSISSCLQQ LSLLMWITQC 120 FLPVFLAQAP SGQRR

Seq ID NO 213 DNA sequence Nucleic Acid Accession ft NM_000555 Coding sequence 416 1498

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CTTATTTTTT ATGAATGTCG GATAGCTGCA CCAGCTTGGT GGGGAAAGGG TTTGATGAAT 60

AGCACAAAGA CACTGGCTGT TCCCTGGAGG CTGTCCCTTT AAAGGAGAAT CTTAGTTTAT 120

TCTGGGGGGA GGGGATGCAC ACATTAGAGT AGGAAAGAGG GCTTGGAATA AAATGAAAAC 180

ACTCCCCCTT CATAGTCATT GTACTGAAAT GCAAAGACTG CTTCCTAAGC TGGAGATGCT 240

AACCTTGGGT AGCTCCTTCT GTTCTCTTCA AGGGGAATTT TGTCAGGCTA TGGATTCATT 300

TACAACTGTT AGTCATGTGG GCATGTGTGA GGAAACAGAT GCCAGTTTTA ATGTATTTAG 360

CCCGAAGTTC CAATTTGATA GGAGCCACTG TCAGTCTCTG AGGTTCCACC AAAATATGGA 420

ACTTGATTTT GGACACTTTG ACGAAAGAGA TAAGACATCC AGGAACATGC GAGGCTCCCG 480

GATGAATGGG TTGCCTAGCC CCACTCACAG CGCCCACTGT AGCTTCTACC GAACCAGAAC 540

CTTGCAGGCA CTGAGTAATG AGAAGAAAGC CAAGAAGGTA CGTTTCTACC GCAATGGGGA 600

CCGCTACTTC AAGGGGATTG TGTACGCTGT GTCCTCTGAC CGTTTTCGCA GCTTTGACGC 660

CTTGCTGGCT GACCTGACGC GATCTCTGTC TGACAACATC AACCTGCCTC AGGGAGTGCG 720

TTACATTTAC ACCATTGATG GATCCAGGAA GATCGGAAGC ATGGATGAAC TGGAGGAAGG 780

GGAAAGCTAT GTCTGTTCCT CAGACAACTT CTTTAAAAAG GTGGAGTACA CCAAGAATGT 840

CAATCCCAAC TGGTCTGTCA ACGTAAAAAC ATCTGCCAAT ATGAAAGCCC CCCAGTCCTT 900

GGCTAGCAGC AACAGTGCAC AGGCCAGGGA GAACAAGGAC TTTGTGCGCC CCAAGCTGGT 960

TACCATCATC CGCAGTGGGG TGAAGCCTCG GAAGGCTGTG CGTGTGCTTC TGAACAAGAA 1020

GACAGCCCAC TCTTTTGAGC AAGTCCTCAC TGATATCACA GAAGCCATCA AACTGGAGAC 1080

CGGGGTTGTC AAAAAACTCT ACACTCTGGA TGGAAAACAG GTAACTTGTC TCCATGATTT 1140

CTTTGGTGAT GATGATGTGT TTATTGCCTG TGGTCCTGAA AAATTTCGCT ATGCTCAGGA 1200

TGATTTTTCT CTGGATGAAA ATGAATGCCG AGTCATGAAG GGAAACCCAT CAGCCACAGC 1260

TGGCCCAAAG GCATCCCCAA CACCTCAGAA GACTTCAGCC AAGAGCCCTG GTCCTATGCG 1320

CCGAAGCAAG TCTCCAGCTG ACTCAGCAAA CGGAACCTCC AGCAGCCAGC TCTCTACCCC 1380

CAAGTCTAAG CAGTCTCCCA TCTCTACGCC CACCAGTCCT GGCAGCCTCC GGAAGCACAA 1440

GGACCTGTAC CTGCCTCTGT CCTTGGATGA CTCGGACTCG CTTGGTGATT CCATGTAAAG 1500

GAGGGGAGAG TGCTCAGAGT CCAGAGTACA AATCCAAGCC TATCATTGTA GTAGGGTACT 1560

TCTGCTCAAG TGTCCAACAG GGCTATTGGT GCTTTCAAGT TTTTATTTTG TTGTTGTTGT 1620

TATTTTGAAA AACACATTGT AATATGTTGG GTTTATTTTC CTGTGATTTC TCCTCTGGGC 1680

CACTGATCCA CAGTTACCAA TTATGAGAGA TAGATTGATA ACCATCCTTT GGGGCAGCAT 1740

TCCAGGGATG CAAAATGTGC TAGTCCATGA CCTTTCAATG GAAAGCTTAG GGGCCTGGGG 1800

TAAATTTGCC CCGTTTAAAT TTGCCCAAAC AGTTTTCCTT TTGTAGAGGG GTGTTTAAAT 1860

ATACAGCAAT TAAAAAGTTT GTGTGGGGAA AAAAAAAACT CATTGGCAGA TCCAAGAATG 1920

ACAAACACAA GTGCCCCTTT TCTCTGGATC TCAAGAATGG TGGAGGACCC TGGAAGGACA 1980

GCAAGGCAGC TCCCCAGCCT CACTCTTCAC TCCTGATTGA GGCCCGGGTT TGTTGTCCAG 2040

CACCAATTCT GGCTGTCAAT GGGGAGAAAT AAACCAACAA CTTATAATTG TGACACCAGA 2100

TGCTTAGGAT CCTGGTGCTG GGTTAGCTAA GAGAATAGAC AGAATTGGAA AATACTGCAG 2160

ACATTTCCGA AGAGTTTATA AAGCACAGTG AATTCCTGGT CAATCTCTCC ACTGAGGCAA 2220

TTTGGAATCA ATAAGCAATT GATAATAGTT TGGAGTAAGG GACTTCATAT ACCTGATTCC 2280

TCTAGAAGGC TGTCTAACAT ACCACATGAT TACATGAACT GTATGGTATC CATCTATCTC 2340

TGTTCTATTG AATGCCTTGT TAACAGCCAA CACTGAAAAC ACTGTGAGAA TTTGTTTTCA 2400

GGTCTGACAC CTTTCAGTCT CTTTTTATAG CAAGAAATCA ATATCCTTTT TATAAAAATT 2460

CATGTCTGTA TTTCAGGAGC AAACTCTTCA GGCTCCTTTT TTATAAACTG GTGATTTTTC 2520

TTTTGTCTAA AAAACACATG AAGAAAATTT ACCAGAAAAA AAAAAAAAAG CCGAAGAATA 2580

ATGTTATTTA GAAATTATGC TGTCACTGCC AAACAGTAAC CTCCAGGAGA AAACAAGATG 2640

AATAGCAGAG GCCAATTCAA TAGAATCAGT TTTTTGATAG CTTTTTAACA GTTATGCTTG 2700

CATTAATAAT TTCAATGTGG ACCAGACATT CTAATTATAT TTTAAATGAA ATGTTACAGC 2760

ATATTTTAAG CAACTCTTTT TATCTATAAT CCTAATATTT CATACTGAAG ACACAGAAAT 2820

CTTTCACTTG TCTTTAACAT TAGAAAGGAT TTCTCTTTAC TAAGGACTGA TCATTTGAAA 2880

TAGTTTTCAG TCTTTTGAGA TACAGGTTTA TAACACTGCT TTTTTTTTCC TGTAAACATA 2940

GCCCATAATG GCAAAAACAA CTAATTTTAA TTGAAGGTCT TGCTTGCCAN TCCTGTGTTG 3000

GCTTTNACCA AATATAAAAA TTCCCTTATT CCTTGGTAAT GGTGCAAATN TTTGGAAAGG 3060

CACAGCATCC AAACCAAGCT GCTGTTTGGC TACTGAATGG CTTGCAGTTG TTCCTCCACT 3120

CTAAATGGAA TGAGCTTGCT GTGTGTGTGT GTGGTGGTGG TGGGAGGGGG TGGTGCATGT 3180

GTGTGTGTGT GTGTGCATCT GCAGCTGCTT CAAAATTAAG AAATACTACA AGACACCCCT 3240

GTAATGGATT GGTGGCAACT GGGTGGCACT GCTGATGTGC ACTGTGTAGG GGGGAACCCA 3300

GTGGTGGTGG GGTATCTCAA ATGCCCCTAG ACAAGCTTCA GATGTCTGTA GCTACCAAAA 3360

ACATTTTCGG TTCAAGAAAA GTGAGATGAT GGTAGTACTG GTTTCTGGTG AAATTGAAAA 3420

ACCCCAAATG ATGAGGATCT CTTTTTGCCC CCTCTCCTTT TTTTGTAAAC CCATTCAAAA 3480

CCATTAATAA GCCCATTTTA CTAANCCCCT ATTTCTTTCT AGAAGCTCAG GGTTTNCTTA 3540

GTGCCTCCCA NAACATTTTG TAGTTAATTG GGAAAAAGTG ATACTTGGAT TAGGGGGTGT 3600

GGGCATAAAG AATGGTGGGA GGCCTGATTT TAAAATTCAG GCCAGAACCC CCAATGACTC 3660

CACCCATAGT NTCACTTTAG GTCTCATTTA GTCCATCACC TTTATTTTAA GTTGAGGAAG 3720

TGGAGGCTGG TAAAGAGCAG GACCAGAGGA AGAATCCAGA TTTCCTTATG CTTGGGCCTC 3780

ACACTAGCTC TNTGAGTATT TCCTTGATTG CGGTATATGT ACTACTAGAA AATACCAAAT 3840

GGATATATTT TCTTTAGGAT AACCTTTGAA CCAACAATNT TCAATAACAA TAGTACATCT 3900 TCCATCTTAC TTTTAATCGA GTATAAGGAA ATGTTTCTTT ATGGCCATTT TGGAGGGAGC 3960

AGGGGATGAG GCTTGGCATA GTCCAAAATT TAAGNCTCCA ATAATTAATT GCATTTTAAA 4020

TTGTTTTAAA TTGGCCCACT TTCAAGGCAA TTTTTTTTGT GTGTCTGTAA CTGAGCTCCT 4080

CCACCCCTGT CATTCACTTC CAATTTTACC CAATCCAATT TTAGCACTCA AGTTCCATTG 4140

TGTTAATTTT TGCACGGTCT ACACACATCA AGTCAGCAAG CATTTGCCAC CACTCCCTAT 4200

ACTTCTCCCT CTTTTTTACA CACACACACA CACACACACA CACAATCCAT CTCTTGCTTG 4260

TTCCTACCTC CCTGATTTTT CTTCCCTACA GAAATAGAAA TAGGGACAAA GAAGGGGAAA 4320

ATGTATATAT TGGGGCTGGG CTGAACAACT AACTTCATAA GTAGTATTAA CTAGGGGTAA 4380

ATTGAGAGAA AAGCTCCTTT TCTCTTCACT GTTTTGGAAA GGATAGCCAT TAGCATGACT 4440

GCTTTGTGTC CTTATGGACT TTAGTATTAG CCTAGATTGA ATTATAGCGT TTTTCTAGCT 4500

GAAGGAACCT TAAGATCACA TCATCTACTC CTCTACTCCA AATTTCTCAT TCTTCAGGCC 4560

AGGAAACCGA GACACAGAGG TAAAGTAATT TCCCCAAGGT CACACAGCTG GCTGGGGCAG 4620

GATTGGGTTT ACAACCCACA TCTCCTGGCT CTTATTCCAG GGCCTTTTCC CACTAAGTAG 4680

TATTGCCTTC CATTAGGCTC CTGAGAGTTA TTTCTCAGGG TCATGTTGCA TCTTGGAGCC 4740

ACATGCTGCT GCCCTGATCT CAGTGGGAAA TNCACCCAGC AACCTAATAC AGCCCCTTTT 4800

CCCTGCATTC ACCTGGTTCC CATCCACATG GGTTGCAGAT GTCCTTGAAG AGAGTGAGGC 4860

ATTGAGGGCC AATAGGAGCA ATGGGGTCCC TGGCCTTGTC CATCTGATTC AGGAGATCAC 4920

TGCTCCATCG TGAGGAGCCC TCTGAATAGC CCCCCACTGA ATGCTTGCCT TGCCCAAATG 4980

GAATGGAGGA AGATTGATTT TCTCCATCAG TTCACCTTGT GTCATCTCAT AATGGTTGGT 5040

CTTTCCAGGC TGAGGGAAAT GTTTCTTGTT TCCANAGTAN AAAAAAGAAA GAGTGGAACA 5100

ATANCTTTGT TCATCCTAAC TTTCTGAGAT GGCTTTTCAA CATTTAAAAA AAACTAGTGT 5160

GGTACCATTC ACTGGCANGA TTTNTTTTAG AATATGGGAG TAAGATGAGG TAGAGAAAAT 5220

AACCTGGTCT CACTGTGGTT GCCCTCATCC ACAATGTCCC CAAAGCCATC CTGCTNTGAT 5280

GAGGACAATT TCCAGGTATA AGCAAGGGGC TTTGTGACAA AAATGTACCC TGGCTGATGT 5340

TAAACATTGG CTCCTGTGTT TGCACCAAAA TAGCAAGCTG TGTGCTCTAT ACACTCTTCC 5400

CATCGTCTTG TGTACACTGC TCCTGTGGCC TTCCACAGCA GAAACCAGGG CAAAAGGGTC 5460

CAAACACATG GTTTTCCTTG CTGCAAGGCT NTTCCTGGGA ACTAAGGGGG TATTTATTAG 5520

TTCAGTTNTA AGAGACCTCC TTCTGGGCTT ACCCCACTCC TCAGGTACTT CTCTCTCCTT 5580

CCTCCTTCTC CTCCACAGTC ACAAGTAACC AAGGAACCTG AAAGTGGATG TGTAGCTATT 5640 TGAAGAAGGC AAGGAACCCT GAGATTCTTC TTTGAATCCT TTAGTCCAAG TCTTAGACCA 5700

GTGATTGGTG CTTACCTTGA ACAAAATTTT GTCTGTGTTC CTAATCCCTT CAATACTNTG 5760

GGTACAATGC TCCCAATCAC CCTGCACATT TGATTCTAAA TGGCTTTTAT TTTTTAAAAA 5820

TCCATATCCC TAGGACAAGA NAACAGGATG CCTATATCCC CAAAATGAGC TCCAGGACAC 5880

TGATGGGAAT GATCCCAANG ATCACCCCAC CTCAGAAAAC GTCTGTGCCA ANAGACTTCC 5940

CCAGATAGAA NCACTGGGAC AGTGGTTTGA ACGACTTCTT TTATGGTTGT CCAGTTTGCT 6000

ATGGAAATAA AAGGCATTGA TTTTTTAAAA AAGATGATTG GAACCTGTCT TTGGCCACAT 6060

AGGGCCACTT GGATCCATTT CCAGGCCTTA CTCATATATT GCCTTCACTG AAGGGCTTTG 6120

GCTTTAAGTC CCAGACTGGT CTCCCAAGTG AACCATAAGT GTTTTGGAGC TCATCTGGGG 6180

TGAGGCATGA GAATGTTGCC CCATCTATCC CTTCAGGAAA AGGTGCCTTC CCTCCCTTTC 6240

TCCTAAAGCC TGGTCCCCAA AAATTGTTTT TGTCTCCAAA AGTCTAGTAT GGTCTTTATA 6300

CACCCANACT CTTAGTGTTG CGTCCTGCCT TGTTTCCTTG TTAAGGATCT ATGCANACCT 6360

CCCGCTTTGG CTTAGCTAGC GTGACATTGG CTATCATTTG ACAAGACTAA CTTTTTTTTT 6420

TTTTTTTTTG ACTGAGTCTC CCTCTGTCAC CTAGGCTGGA GTGCAGTGGC ACAATCTTGG 6480

CTCGCTGCAA CCTTCACCCT TCACCTCCCA GGTCGAAGCG ATTCTCCTGC CTCAGTCTCC 6540

CGAGTAGCTG GGATTACAGG CGTGCGCCAC CAAATCTGGC TATTTTTTTA TTATTATTAT 6600

TTTTAGTAGA GATGGGGTTT CACCATGTTG GCCAGACTGG TCTTGAACTC TTGGCCTCAA 6660

ATTATCTGCC CACCTCGGCC TCCCAAAGTG CTGGGATTAC AGGCATGAGC ACCATGCCCA 6720

GCTGACAAGA CTAATTTTTT ATCCCTTGGT TTATTGGCTT CAACATCTTC TGGAATCAGA 6780

GGTGATTTTT TCTTACCTTG GATGCCTGAG ACTAGGGGAG TATAGAATTC CAATTGGTAA 6840

TTAAGGCATC TTTCTGCTCC TGATCAGAAG GGCAGGTTAG TTGGGAGAGG TCAGATGGCA 6900

CAACAGAAGT CACCTTGTAA GTAAGGCAAA GACTTTGAAG GCATTAGCGT TTCTCATTAC 6960

TTAGGTCAAT AACCTTGAGG GAATCAATGG CTTTTTTGCC GCTCTACCTC TTTGTGTATC 7020

TCTTTGACTT TTCTTTCTCT GTCTAGTTTC CTCTGTTCTC AGTTTATATT CTATGTTATC 7080

AGTCTCTCTT TCCACAGTAC AAACATCCAT CCTTTCTCCT GTGCAATTCT GTCTCTCCCT 7140

CTTATTATCT TTATTTGTAC TTTTTCCTTC CTCCCTGTCT AGGCATTGGG CATGTGCCTC 7200

TTCTTAGCCT GTGATTTTGC CTTGGGACTG ATGATAAATT ATTTCCAGAT TCAATCAGCC 7260

CTGGTCCTAC CCCAGTCCAA TCAGAAGTAT GTTGGTGGGG AATCAACCTG ATCCTGGCCC 7320

TTTCTTCTTC TCCATTTTCA TTCGTAATCC CCCTCAGCAG ATCTTTACAA GCAGTTTCCT 7380

TATAGCTCAT GTATCTTTAG GTCTTTGCCT TCCAAGCACT GTACAGAATA CTTTGTGGTT 7440 CCTTTTTAGT CTGACATTTT GTGGAGCAGT GAAGCGTGCT CAGAGACATA ATCAGCTGAA 7500

GAGAAAAAAT CCACCCATGG ATTTATATCA GCTAAATACT AATAATTGAT TTTGTTTGAT 7560

GTGCCCATAA TTTTTAAAGC TGCAATATAA TATAATGAGG GACCACAGGT AATTTCTCCT 7620

GTCATTTGTT TTGGCTGGAT GGGGGTGGGG GAGTAATTGC TTAAAGTTTT ACCATTACAC 7680

ATTAAACTCT CTATAATAAT CTTGTTTGGG GCTTGCTAAC TGTTGAGCTG TTTTAACTAA 7740

ACTGGTAGGC AATCGGAGTT GATTTAAATG AAAAGATAAT TTAACAAATC TATACTATAA 7800

AAAGAGACAT TTGCTTAATT GACATGTATT TTTTCCTTCT GAGTCACCTA AACATTTACT 7860

CTTGACACCA ACTGTTCATG ATACTGAATA GACAGTCCAT ATAAGAGAAA TTAGTGGACC 7920

TAAAGAAGCC AGATTGTAGG TGTTAATTTA TTAAACAGAA TTGCAAAGCC CTTGGAAATG 7980

TCACTGCTTG GCAATACCAT ATGGCATGCC AAAATTTACA ATGACTTTTC TTTATAAGTT 8040

ATCCAAAAGG GATTTGAACA AGTAAGAGGT TATGCCAAAA TGTCTCCAAT GTATGGTCCT 8100

GTAATATATT GCAGCTTGAA GCCAATGATC CCTTATGACT TGTATACAAC TAATGCATGT 8160

TTTATTGAAT TTTGCATTTC CCACGTGTGG TAAGTCTTTA AAATGTTTTT GATCACCTTT 8220

NTGTGCCATT AAACTTGTAC AGAAAATGTT TTTATGGCCA TTTTCAAAGG GAGAAAGTTT 8280

AAAATGGAAA CAGCCCACCC TTTCTGCCCT ATAGCTGTAG TTAGAATTGA GTACCTGTAG 8340

CAAAACAGCT GTAATTGGTG GTTGTAGTGT TAGAGGTGTT AGCTTGCTAG TGACTAGCTT 8400

TGGAGAGTAA ATGCATGGTA TTGTACATCA CATTTCTTAA CTCGTTTTAA CCTCTGAAAA 8460

GAATATATTC TTCTTTGTAG TCCTTCTTCC CACCCCCTTG CCCTCTCCCT CTCCCTGCTC '8520

CCAGTTGTCT TACAGTTGTA AATATCTGAT TTGAGGCCCA ATAACTCTTG CCAAGTAAAG 8580

TCAGCAAACA ACAAACAAAC CAAAATGTGG GGAAAAGGCA TTTCTCAACC ATCTCTCAGC 8640

AGTTATTGAT CATTTCTTAA GGAACAGCAT TGTGATCAAA GACTCAACTT TACGTAAAAA 8700

TCAGTGGTAA ATTGGGGTTG TATTGGCCAT TGATTACATT CAGGATTGAA TAGTTTTCAG 8760

AATCACATGT AATCCAAAGA CAGTAGGTAG TGATGTCCCT TATCCCTGCA GCTGTTTTAA 8820

GATAGAGACC TCAGAAGACT CTGCTTGACC GATGACCAAT AATTATTTGA AAAAAAAAGA 8880

AAAAATGAGA GAAATAAAAC AGATATTTAA GAACTTTAGC CACCTATTTA GAATAGTTAT 8940

AGCCAGAAAA AAAAACAAGG GCATGAGTTC AAATGCATTA CTATCAGTGT CCTAGGCAAT 9000

ACCTAACCTA CTCTGAAATT GTGATTCAAA AGCAGTATTT CAAGAGGCAT TCTCCTTTTT 9060

TGGTTTGCTG ACCCCACTTG GACTGGTAGG TTTGGTGAGG CCCCCATAAA CCAGCTGGAG 9120 AGACCCTTT TCATCTC T CCTGTAAC AC CCTCTTC CCCCACCCCC TCCGCAATTC 9180

AATGAGGGCT TTCTTGGGTC AGAGGACTTC AAGGTTGTCT AGAGAAGTTT GCCATGTGTG 9240

TAAGGTGCTG TGAACTGTGA GTGCTGAAGA TTCGCAGCAT TCAATACCAG GCAGCCAAAG 9300

AGCTGCTCTT GCAATTATTT TGGCTCTCAA GCTCTGTTCT TCATCGCATT CTCATTTCTG 9360 TGTACATTTG CAAGATGTGT GTAATGTCAT TTTCCAAAAA TAAAATTTGA TTTCAAT

Seq ID NO: 214 Protein sequence: Protein Accession ft: NP_000546

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MELDFGHFDE RDKTSRNMRG SRMNGLPSPT HSAHCSFYRT RTLQALSNEK KAKKVRFYRN 60

GDRYFKGIVY AVSSDRFRSF DALLADLTRS LSDNINLPQG VRYIYTIDGS RKIGSMDELE 120

EGESYVCSSD NFFKKVEYTK NVNPNWSVNV KTSANMKAPQ SLASSNSAQA RENKDFVRPK 180

LVTIIRSGVK PRKAVRVLLN KKTAHSFEQV LTDITEAIKL ETG KKLYT LDGKQVTCLH 240

DFFGDDDVFI ACGPEKFRYA QDDFSLDENE CRVMKGNPSA TAGPKASPTP QKTSAKSPGP 300 MRRSKSPADS ANGTSSSQLS TPKSKQSPIS TPTSPGSLRK HKDLYLPLSL DDSDSLGDSM

Seq ID NO : 215 DNA sequence Nucleic Acid Accession ft : NM_130467 Coding sequence : 312 . . 644

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GGCACGAGGC AGAGCTCTGC AAGGAGAGGT TGTGTCTTCG TTCTTTCCGC CATCTTCGTT 60

CTTTCCAACA TCTTCGTTCT TTCTCACTGA CCGAGACTCA GCCGGTAGGT CTGCAGAGTG 120

GTCTTCCTGG TAATTTAGTT GTGAGTGAAT GTGTGGAGGA GCCAGCGGGC TTAGGACAGG 180

TCCTGTGGCA CAGTCCGTGG CTTTGAGGGA AAAGGGCCTC GCGGTGGTCC TCCGCCTTCC 240

CCCAGGTCGT GATGCAGGCG CCATGGGCCG GTAATCGTGG CTGGGCTGGA ACGAGGGAGG 300

AAGTGAGAGA TATGAGTGAG CATGTAACAA GATCCCAATC CTCAGAAAGA GGAAATGACC 360

AAGAGTCTTC CCAGCCAGTT GGACCTGTGA TTGTCCAGCA GCCCACTGAG GAAAAACGTC 420

AAGAAGAGGA ACCACCAACT GATAATCAGG GTATTGCACC TAGTGGGGAG ATCAAAAATG 480

AAGGAGCACC TGCTGTTCAA GGGACTGATG TGGAAGCTTT TCAACAGGAA CTGGCTCTGC 540

TTAAGATAGA GGATGCACCT GGAGATGGTC CTGATGTCAG GGAGGGGACT CTGCCCACTT 600

TTGATCCCAC TAAAGTGCTG GAAGCAGGTG AAGGGCAACT ATAGGTTTAA ACCAAGACAA 660

ATGAAGACTG AAACCAAGAA TATTGTTCTT ATGCTGGAAA TTTGACTGCT AACATTCTCT 720 TAATAAAGTT TTACAGTTTT CTGCAAAAAA AAAAAAAAAA AAA

Seq ID NO: 216 Protein sequence: Protein Accession ft: NP_569734

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MSEHVTRSQS SERGNDQESS QPVGPVIVQQ PTEEKRQEEE PPTDNQGIAP SGEIKNEGAP AVQGTDVEAF QQELALLKIE DAPGDGPDVR EGTLPTFDPT KVLEAGEGQL

Seq ID NO: 217 DNA sequence

Nucleic Acid Accession ft: NM_001476.1

Coding sequence: 82..435

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GCCAGGGAGC TGTGAGGCAG TGCTGTGTGG TTCCTGCCGT CCGGACTCTT TTTCCTCTAC 60

TGAGATTCAT CTGTGTGAAA TATGAGTTGG CGAGGAAGAT CGACCTATTA TTGGCCTAGA 120

CCAAGGCGCT ATGTACAGCC TCCTGAAGTG ATTGGGCCTA TGCGGCCCGA GCAGTTCAGT 180

GATGAAGTGG AACCAGCAAC ACCTGAAGAA GGGGAACCAG CAACTCAACG TCAGGATCCT 240

GCAGCTGCTC AGGAGGGAGA GGATGAGGGA GCATCTGCAG GTCAAGGGCC GAAGCCTGAA 300

GCTGATAGCC AGGAACAGGG TCACCCACAG ACTGGGTGTG AGTGTGAAGA TGGTCCTGAT 360

GGGCAGGAGG TGGACCCGCC AAATCCAGAG GAGGTGAAAA CGCCTGAAGA AGGTGAAAAG 420

CAATCACAGT GTTAAAAGAA GACACGTTGA AATGATGCAG GCTGCTCCTA TGTTGGAAAT 480 TTGTTCATTA AAATTCTCCC AATAAAGCTT TACAGCCTTC TGCAAAA

Seq ID NO: 218 Protein sequence: Protein Accession ft: NP_001467.1

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MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE 60 DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEVDPP NPEEVKTPEE GEKQSQC

Seq ID NO: 219 DNA sequence Nucleic Acid Accession ft: NM_001476 Coding sequence: 90-3671

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ACAGCGGAGC GCAGAGTGAG AACCACCAAC CGAGGCGCCG GGCAGCGACC CCTGCAGCGG 60

AGACAGAGAC TGAGCGGCCC GGCACCGCCA TGCCTGCGCT CTGGCTGGGC TGCTGCCTCT 120

GCTTCTCGCT CCTCCTGCCC GCAGCCCGGG CCACCTCCAG GAGGGAAGTC TGTGATTGCA 180

ATGGGAAGTC CAGGCAGTGT ATCTTTGATC GGGAACTTCA CAGACAAACT GGTAATGGAT 240

TCCGCTGCCT CAACTGCAAT GACAACACTG ATGGCATTCA CTGCGAGAAG TGCAAGAATG 300

GCTTTTACCG GCACAGAGAA AGGGACCGCT GTTTGCCCTG CAATTGTAAC TCCAAAGGTT 360 CTCTTAGTGC TCGATGTGAC AACTCTGGAC GGTGCAGCTG TAAACCAGGT GTGACAGGAG 420

CCAGATGCGA CCGATGTCTG CCAGGCTTCC ACATGCTCAC GGATGCGGGG TGCACCCAAG 480

ACCAGAGACT GCTAGACTCC AAGTGTGACT GTGACCCAGC TGGCATCGCA GGGCCCTGTG 540

ACGCGGGCCG CTGTGTCTGC AAGCCAGCTG TTACTGGAGA ACGCTGTGAT AGGTGTCGAT 600

CAGGTTACTA TAATCTGGAT GGGGGGAACC CTGAGGGCTG TACCCAGTGT TTCTGCTATG 660

GGCATTCAGC CAGCTGCCGC AGCTCTGCAG AATACAGTGT CCATAAGATC ACCTCTACCT 720

TTCATCAAGA TGTTGATGGC TGGAAGGCTG TCCAACGAAA TGGGTCTCCT GCAAAGCTCC 780

AATGGTCACA GCGCCATCAA GATGTGTTTA GCTCAGCCCA ACGACTAGAC CCTGTCTATT 840

TTGTGGCTCC TGCCAAATTT CTTGGGAATC AACAGGTGAG CTATGGGCAA AGCCTGTCCT 900

TTGACTACCG TGTGGACAGA GGAGGCAGAC ACCCATCTGC CCATGATGTG ATTCTGGAAG 960

GTGCTGGTCT ACGGATCACA GCTCCCTTGA TGCCACTTGG CAAGACACTG CCTTGTGGGC 1020

TCACCAAGAC TTAGACATTC AGGTTAAATG AGCATCCAAG CAATAATTGG AGCCCCCAGC 1080

TGAGTTACTT TGAGTATCGA AGGTTACTGC GGAATCTCAC AGCCCTCCGC ATCCGAGCTA 1140

CATATGGAGA ATACAGTACT GGGTACATTG ACAATGTGAC CCTGATTTCA GCCCGCCCTG 1200

TCTCTGGAGC CCCAGCACCC TGGGTTGAAC AGTGTATATG TCCTGTTGGG TACAAGGGGC 1260

AATTCTGCCA GGATTGTGCT TCTGGCTACA AGAGAGATTC AGCGAGACTG GGGCCTTTTG 1320

GCACCTGTAT TCCTTGTAAC TGTCAAGGGG GAGGGGCCTG TGATCCAGAC ACAGGAGATT 1380

GTTATTCAGG GGATGAGAAT CCTGACATTG AGTGTGCTGA CTGCCCAATT GGTTTCTACA 1440

ACGATCCGCA CGACCCCCGC AGCTGCAAGC CATGTCCCTG TCATAACGGG TTCAGCTGCT 1500

CAGTGATGCC GGAGACGGAG GAGGTGGTGT GCAATAACTG CCCTCCCGGG GTCACCGGTG 1560

CCCGCTGTGA GCTCTGTGCT GATGGCTACT TTGGGGACCC CTTTGGTGAA CATGGCCCAG 1620

TGAGGCCTTG TCAGCCCTGT CAATGCAACA ACAATGTGGA CCCCAGTGCC TCTGGGAATT 1680

GTGACCGGCT GACAGGCAGG TGTTTGAAGT GTATCCACAA CACAGCCGGC ATCTACTGCG 1740

ACCAGTGCAA AGCAGGCTAC TTCGGGGACC CATTGGCTCC CAACCCAGCA GACAAGTGTC 1800

GAGCTTGCAA CTGTAACCCC ATGGGCTCAG AGCCTGTAGG ATGTCGAAGT GATGGCACCT 1860

GTGTTTGCAA GCCAGGATTT GGTGGCCCCA ACTGTGAGCA TGGAGCATTC AGCTGTCCAG 1920

CTTGCTATAA TCAAGTGAAG ATTCAGATGG ATCAGTTTAT GCAGCAGCTT CAGAGAATGG 1980

AGGCCCTGAT TTCAAAGGCT CAGGGTGGTG ATGGAGTAGT ACCTGATACA GAGCTGGAAG 2040

GCAGGATGCA GCAGGCTGAG CAGGCCCTTC AGGACATTCT GAGAGATGCC CAGATTTCAG 2100

AAGGTGCTAG CAGATCCCTT GGTCTCCAGT TGGCCAAGGT GAGGAGCCAA GAGAACAGCT 2160

ACCAGAGCCG CCTGGATGAC CTCAAGATGA CTGTGGAAAG AGTTCGGGCT CTGGGAAGTC 2220

AGTACCAGAA CCGAGTTCGG GATACTCACA GGCTCATCAC TCAGATGCAG CTGAGCCTGG 2280

CAGAAAGTGA AGCTTCCTTG GGAAACACTA ACATTCCTGC CTCAGACCAC TACGTGGGGC 2340

CAAATGGCTT TAAAAGTCTG GCTCAGGAGG CCACAAGATT AGCAGAAAGC CACGTTGAGT 2400

CAGCCAGTAA CATGGAGCAA CTGACAAGGG AAACTGAGGA CTATTCCAAA CAAGCCCTCT 2460

CACTGGTGCG CAAGGCCCTG CATGAAGGAG TCGGAAGCGG AAGCGGTAGC CCGGACGGTG 2520

CTGTGGTGCA AGGGCTTGTG GAAAAATTGG AGAAAACCAA GTCCCTGGCC CAGCAGTTGA 2580

CAAGGGAGGC CACTCAAGCG GAAATTGAAG CAGATAGGTC TTATCAGCAC AGTCTCCGCC 2640

TCCTGGATTC AGTGTCTCGG CTTCAGGGAG TCAGTGATCA GTCCTTTCAG GTGGAAGAAG 2700

CAAAGAGGAT CAAACAAAAA GCGGATTCAC TCTCAACGCT GGTAACCAGG CATATGGATG 2760

AGTTCAAGCG TACACAAAAG AATCTGGGAA ACTGGAAAGA AGAAGCACAG CAGCTCTTAC 2820

AGAATGGAAA AAGTGGGAGA GAGAAATCAG ATCAGCTGCT TTCCCGTGCC AATCTTGCTA 2880

AAAGCAGAGC ACAAGAAGCA CTGAGTATGG GCAATGCCAC TTTTTATGAA GTTGAGAGCA 2940

TCCTTAAAAA CCTCAGAGAG TTTGACCTGC AGGTGGACAA CAGAAAAGCA GAAGCTGAAG 3000

AAGCCATGAA GAGACTCTCC TACATCAGCC AGAAGGTTTC AGATGCCAGT GACAAGACCC 3060

AGCAAGCAGA AAGAGCCCTG GGGAGCGCTG CTGCTGATGC ACAGAGGGCA AAGAATGGGG 3120

CCGGGGAGGC CCTGGAAATC TCCAGTGAGA TTGAACAGGA GATTGGGAGT CTGAACTTGG 3180

AAGCCAATGT GACAGCAGAT GGAGCCTTGG CCATGGAAAA GGGACTGGCC TCTCTGAAGA 3240

GTGAGATGAG GGAAGTGGAA GGAGAGCTGG AAAGGAAGGA GCTGGAGTTT GACACGAATA 3300

TGGATGCAGT ACAGATGGTG ATTACAGAAG CCCAGAAGGT TGATACCAGA GCCAAGAACG 3360

CTGGGGTTAC AATCCAAGAC ACACTCAACA CATTAGACGG CCTCCTGCAT CTGATGGACC 3420

AGCCTCTCAG TGTAGATGAA GAGGGGCTGG TCTTACTGGA GCAGAAGCTT TCCCGAGCCA 3480

AGACCCAGAT CAACAGCCAA CTGCGGCCCA TGATGTCAGA GCTGGAAGAG AGGGCACGTC 3540

AGCAGAGGGG CCACCTCCAT TTGCTGGAGA CAAGCATAGA TGGGATTCTG GCTGATGTGA 3600

AGAACTTGGA GAACATTAGG GACAACCTGC CCCCAGGCTG CTACAATACC CAGGCTCTTG 3660

AGCAACAGTG AAGCTGCCAT AAATATTTCT CAACTGAGGT TCTTGGGATA CAGATCTCAG 3720

GGCTCGGGAG CCATGTCATG TGAGTGGGTG GGATGGGGAC ATTTGAACAT GTTTAATGGG 3780

TATGCTCAGG TCAACTGACC TGACCCCATT CCTGATCCCA TGGCCAGGTG GTTGTCTTAT 3840

TGCACCATAC TCCTTGCTTC CTGATGCTGG GCAATGAGGC AGATAGCACT GGGTGTGAGA 3900

ATGATCAAGG ATCTGGACCC CAAAGAATAG ACTGGATGGA AAGACAAACT GCACAGGCAG 3960

ATGTTTGCCT CATAATAGTC GTAAGTGGAG TCCTGGAATT TGGACAAGTG CTGTTGGGAT 4020

ATAGTCAACT TATTCTTTGA GTAATGTGAC TAAAGGAAAA AACTTTGACT TTGCCCAGGC 4080

ATGAAATTCT TCCTAATGTC AGAACAGAGT GCAACCCAGT CACACTGTGG CCAGTAAAAT 4140

ACTATTGCCT CATATTGTCC TCTGCAAGCT TCTTGCTGAT CAGAGTTCCT CCTACTTACA 4200

ACCCAGGGTG TGAACATGTT CTCCATTTTC AAGCTGGAAG AAGTGAGCAG TGTTGGAGTG 4260

AGGACCTGTA AGGCAGGCCC ATTCAGAGCT ATGGTGCTTG CTGGTGCCTG CCACCTTCAA 4320

GTTCTGGACC TGGGCATGAC ATCCTTTCTT TTAATGATGC CATGGCAACT TAGAGATTGC 4380

ATTTTTATTA AAGCATTTCC TACCAGCAAA GCAAATGTTG GGAAAGTATT TACTTTTTCG 4440

GTTTCAAAGT GATAGAAAAG TGTGGCTTGG GCATTGAAAG AGGTAAAATT CTCTAGATTT 4500

ATTAGTCCTA ATTCAATCCT ACTTTTCGAA CACCAAAAAT GATGCGCATC AATGTATTTT 4560

ATCTTATTTT CTCAATCTCC TCTCTCTTTC CTCCACCCAT AATAAGAGAA TGTTCCTACT 4620

CACACTTCAG CTGGGTCACA TCCATCCCTC CATTCATCCT TCCATCCATC TTTCCATCCA 4680

TTACCTCCAT CCATCCTTCC AACATATATT TATTGAGTAC CTACTGTGTG CCAGGGGCTG 4740

GTGGGACAGT GGTGACATAG TCTCTGCCCT CATAGAGTTG ATTGTCTAGT GAGGAAGACA 4800

AGCATTTTTA AAAAATAAAT TTAAACTTAC AAACTTTGTT TGTCACAAGT GGTGTTTATT 4860

GCAATAACCG CTTGGTTTGC AACCTCTTTG CTCAACAGAA CATATGTTGC AAGACCCTCC 4920

CATGGGGGCA CTTGAGTTTT GGCAAGGCTG ACAGAGCTCT GGGTTGTGCA CATTTCTTTG 4980

CATTCCAGCT GTCACTCTGT GCCTTTCTAC AACTGATTGC AACAGACTGT TGAGTTATGA 5040

TAACACCAGT GGGAATTGCT GGAGGAACCA GAGGCACTTC CACCTTGGCT GGGAAGACTA 5100

TGGTGCTGCC TTGCTTCTGT ATTTCCTTGG ATTTTCCTGA AAGTGTTTTT AAATAAAGAA 5160 CAATTGTTAG ATGCC

Seq ID NO: 220 Protein sequence: Protein Accession #:NP_005553

1 11 21 31 41 51

I I I I I I MPALWLGCCL CFSLLLPAAR ATSRREVCDC NGKSRQCIFD RELHRQTGNG FRCLNCNDNT 60 DGIHCEKCKN GFYRHRERDR CLPCNCNSKG SLSARCDNSG RCSCKPGVTG ARCDRCLPGF 120 HMLTDAGCTQ DQRLLDSKCD CDPAGIAGPC DAGRCVCKPA VTGERCDRCR SGYYNLDGGN 180 PEGCTQCFCY GHSASCRSSA EYSVHKITST FHQDVDGWKA VQRNGSPAKL QWSQRHQDVF 240 SSAQRLDPVY FVAPAKFLGN QQVSYGQSLS FDYRVDRGGR HPSAHDVILE GAGLRITAPL 300

MPLGKTLPCG LTKTYTFRLN EHPSNNWSPQ LSYFEYRRLL RNLTALRIRA TYGEYSTGYI 360 DNVTLISARP VSGAPAPWVE QCICPVGYKG QFCQDCASGY KRDSARLGPF GTCIPCNCQG 420 GGACDPDTGD CYSGDENPDI ECADCPIGFY NDPHDPRSCK PCPCHNGFSC SVMPETEEW 480 CNNCPPGVTG ARCELCADGY FGDPFGEHGP VRPCQPCQCN NNVDPSASGN CDRLTGRCLK 540 , CIHNTAGIYC DQCKAGYFGD PLAPNPADKC RACNCNPMGS EPVGCRSDGT CVCKPGFGGP 600 NCEHGAFSCP ACYNQVKIQM DQFMQQLQRM EALISKAQGG DGWPDTELE GRMQQAEQAL 660 QDILRDAQIS EGASRSLGLQ LAKVRSQENS YQSRLDDLKM TVERVRALGS QYQNRVRDTH 720 RLITQMQLSL AESEASLGNT NIPASDHYVG PNGFKSLAQE ATRLAESHVE SASNMEQLTR 780 ETEDYSKQAL SLVRKALHEG VGSGSGSPDG AWQGLVEKL EKTKSLAQQL TREATQAEIE 840 ADRSYQHSLR LLDSVSRLQG VSDQSFQVEE AKRIKQKADS LSTLVTRHMD EFKRTQKNLG 900

NWKEEAQQLL QNGKSGREKS DQLLSRANLA KSRAQEALSM GNATFYEVES ILKNLREFDL 960 QVDNRKAEAE EAMKRLSYIS QKVSDASDKT QQAERALGSA AADAQRAKNG AGEALEISSE 1020 IEQEIGSLNL EANVTADGAL AMEKGLASLK SEMREVEGEL ERKELEFDTN MDAVQMVITE 1080 AQKVDTRAKN AGVTIQDTLN TLDGLLHLMD QPLSVDEEGL VLLEQKLSRA KTQINSQLRP 1140 MMSELEERAR QQRGHLHLLE TSIDGILADV KNLENIRDNL PPGCYNTQAL EQQ

Seq ID NO : 221 DNA sequence Nucleic Acid Accession ft : NM_016529 Coding sequence : 13-1854

11 21 31 41 51

GTCAAGAAAA GAATGTCTGT AATTGTTCGA ACTCCTTCAG GACGACTTCG GCTTTACTGT 60 AAAGGGGCTG ATAATGTGAT TTTTGAGAGA CTTTCAAAAG ACTCAAAATA TATGGAGGAA 120 ACATTATGCC ATCTGGAATA CTTTGCCACG GAAGGCTTGC GGACTCTCTG TGTGGCTTAT 180 GCTGATCTCT CTGAGAATGA GTATGAGGAG TGGCTGAAAG TCTATCAGGA AGCCAGCACC 240 ATATTGAAGG ACAGAGCTCA ACGGTTGGAA GAGTGTTACG AGATCATTGA GAAGAATTTG 300 CTGCTACTTG GAGCCACAGC CATAGAAGAT CGCCTTCAAG CAGGAGTTCC AGAAACCATC 360 GCAACACTGT TGAAGGCAGA AATTAAAATA TGGGTGTTGA CAGGAGACAA ACAAGAAACT 420 GCGATTAATA TAGGGTATTC CTGCCGATTG GTATCGCAGA ATATGGCCCT TATCCTATTG 480 AAGGAGGACT CTTTGGATGC CACAAGGGCA GCCATTACTC AGCACTGCAC TGACCTTGGG 540 AATTTGCTGG GCAAGGAAAA TGACGTGGCC CTCATCATCG ATGGCCACAC CCTGAAGTAC 600 GCGCTCTCCT TCGAAGTCCG GAGGAGTTTC CTGGATTTGG CACTCTCGTG CAAAGCGGTC 660 ATATGCTGCA GAGTGTCTCC TCTGCAGAAG TCTGAGATAG TGGATGTGGT GAAGAAGCGG 720 GTGAAGGCCA TCACCCTCGC CATCGGAGAC GGCGCCAACG ATGTCGGGAT GATCCAGACA 780 GCCCACGTGG GTGTGGGAAT CAGTGGGAAT GAAGGCATGC AGGCCACCAA CAACTCGGAT 840 TACGCCATCG CACAGTTTTC CTACTTAGAG AAGCTTCTGT TGGTTCATGG AGCCTGGAGC 900 TACAACCGGG TGACCAAGTG CATCTTGTAC TGCTTCTATA AGAACGTGGT CCTGTATATT 960 ATTGAGCTTT GGTTCGCCTT TGTTAATGGA TTTTCTGGGC AGATTTTATT TGAACGTTGG 1020 TGCATCGGCC TGTACAATGT GATTTTCACC GCTTTGCCGC CCTTCACTCT GGGAATCTTT 1080 GAGAGGTCTT GCACTCAGGA GAGCATGCTC AGGTTTCCCC AGCTCTACAA AATCACCCAG 1140 AATGGCGAAG GCTTCAACAC AAAGGTTTTC TGGGGTCACT GCATCAACGC CTTGGTCCAC 1200 TCCCTCATCC TCTTCTGGTT TCCCATGAAA GCTCTGGAGC ATGATACTGT GTTTGACAGT 1260 GGTCATGCTA CCGACTATTT ATTTGTTGGA AATATTGTTT ACACATATGT TGTTGTTACT 1320 GTTTGTCTGA AAGCTGGTTT GGAGACCACA GCTTGGACTA AATTCAGTCA TCTGGCTGTC 1380 TGGGGAAGCA TGCTGACCTG GCTGGTGTTT TTTGGCATCT ACTCGACCAT CTGGCCCACC 1440 ATTCCCATTG CTCCAGATAT GAGAGGACAG GCAACTATGG TCCTGAGCTC CGCACACTTC 1500 TGGTTGGGAT TATTTCTGGT TCCTACTGCC TGTTTGATTG AAGATGTGGC ATGGAGAGCA 1560 GCCAAGCACA CCTGCAAAAA GACATTGCTG GAGGAGGTGC AGGAGCTGGA AACCAAGTCT 1620 CGAGTCCTGG GAAAAGCGGT GCTGCGGGAT AGCAATGGAA AGAGGCTGAA CGAGCGCGAC 1680 CGCCTGATCA AGAGGCTGGG CCGGAAGACG CCCCCGACGC TGTTCCGGGG CAGCTCCCTG 1740 CAGCAGGGCG TCCCGCATGG GTATGCTTTT TCTCAAGAAG AACACGGAGC TGTTAGTCAG 1800 GAAGAAGTCA TCCGTGCTTA TGACACCACC AAAAAGAAAT CCAGGAAGAA ATAAGACATG 1860 AATTTTCCTG ACTGATCTTA GGAAAGAGAT TCAGTTTGTT GCACCCAGTG TTAACACATC 1920 TTTGTCAGAG AAGACTGGCG TCCAAGGCCA AAACACCAGG AAACACATTT CTGTGGCCTT 1980 AGTTAAGCAG TTTGTTAGTT ACATATTCCC TCGCAAACCT GGAGTGCAGA CCACAGGGGA 2040 AGCTATCTTT GCCCTCCCAA CTCGTCTGCA GTGCTTAGCC TAACTTTTGT TTATGTCGTT 2100 ATGAAGCATT CAACTGTGCT CTGTGAGGTC TCAAATTAAA AACATTATGT TTCACCAATA 2160 AGAAAAAAAA AAAAAAA

Seq ID NO: 222 Protein sequence: Protein Accession ft: NP_057613

11 21 31 41 51

I I I I

MSVIVRTPSG RLRLYCKGAD NVIFERLSKD SKYMEETLCH LEYFATEGLR TLCVAYADLS 60 ENEYEEWLKV YQEASTILKD RAQRLEECYE IIEKNLLLLG ATAIEDRLQA GVPETIATLL 120 KAEIKIWVLT GDKQETAINI GYSCRLVSQN MALILLKEDS LDATRAAITQ HCTDLGNLLG 180 KENDVALIID GHTLKYALSF EVRRSFLDLA LSCKAVICCR VSPLQKSEIV DWKKRVKAI 240 TLAIGDGAND VGMIQTAHVG VGISGNEGMQ ATNNSDYAIA QFSYLEKLLL VHGAWSYNRV 300 TKCILYCFYK NWLYIIELW FAFVNGFSGQ ILFERWCIGL YNVIFTALPP FTLGIFERSC 360 TQESMLRFPQ LYKITQNGEG FNTKVFWGHC INALVHSLIL FWFPMKALEH DTVFDSGHAT 420 DYLFVGNIVY TYWTVCLK AGLETTAWTK FSHLAVWGSM LTWLVFFGIY STIWPTIPIA 480 PDMRGQATMV LSSAHFWLGL FLVPTAC IE DVAWRAAKHT CKKTLLEEVQ ELETKSRVLG 540 KAVLRDSNGK RLNERDRLIK RLGRKTPPTL FRGSSLQQGV PHGYAFSQEE HGAVSQEEVI 600 RAYDTTKKKS RKK

Seq ID NO: 223 DNA sequence Nucleic Acid Accession ft: BC017001 Coding sequence: 1-394

11 21 31 AACGCTGGGC AGGGCCGGCG CGGGTCGGGG GGCGCCCGAG GGGCCCGGGC CGAGCGGCGG 60

CGCGCAGGGC GGCAGCATCC ACTCGGGCCG CATCGCCGCG GTGCACAACG TGCCGCTGAG 120

CGTGCTCATC CGGCCGCTGC CGTCCGTGTT GGACCCCGCC AAGGTGCAGA GCCTCGTGGA 180

CACGATCCGG GAGGACCCAG ACAGCGTGCC CCCCATCGAT GTCCTCTGGA TCAAAGGGGC 240

CCAGGGAGGT GACTACTTCT ACTCCTTTGG GGGCTGCCAC CGCTACGCGG CCTACCAGCA 300

ACTGCAGCGA GAGACCATCC CCGCCAAGCT TGTCCAGTCC ACTCTCTCAG ACCTAAGGGT 360

GTACCTGGGA GCATCCACAC CAGACTTGCA GTAGCAGCCT CCTTGGCACC TGCTGCCACC 420

TTCAAGAGCC CAGAAGACAC ACCTGGCCTC CAGCAGGCTG GGCCATGCAG AAGGGATAGC 480

AGGGGTGCAT TCTCTTTGCA CCTGGCGAGA GGGTCTGACT CTGGGCACCC CTCTCACCGG 540

CTACAAGGCC TTGGACTCAC TGTACAGTGT GGGAGCCCCA GTTCCCACCT CTGTGACAAT 600

AGGATCATGG CCTTACCCTT GAAGCATTAC CGAGAAGGAG AACAGAGATG GGCTTGAAGA 660

GCCACGTGCT GCCGGCTCCA AATTCCCAAG GACAAGGATC CCTCTGCATT TTTGTCTATG 720

TAACCTCTTA TATGGACTAC ATTCAGCTGC AAGGAAAGGA AAACCTTGAT TGCAGTGGTT 780

TAAACAAACA GAAGATTGTT TTTCCACATA GCATGGATTC TGGAGATGGG TGGCTAATGG 840

TATTGGTTCA ACAACTCCAC GGAGGTAGGG GTCACGTCTT GGATCCTTTT GCCTTAATCT 900

CAGTGCTCGT TACTTCATGG TCCCAAGATG GCTGCTGTAT CCCCAAGAAT CATGTCTGCG 960

TTCAAGGAAG GAGGGGTGGA GGAAGAGGAA GGGCCAAACT AGCTGGACCC GTCACCTTCT 1020

ATCAGAAAGT AAAACCTCGT CAGAAGTCTG TTTCCTGCTC TCTCCCTCTG CATATCTTCA 1080

CTTAGATGCC CTTGGCCCGA GCCAGCTACC ATTGCACCTC TAGCTGCAAA CAAAGCTAAG 1140

ACAGCAGGGA ACAGAATTGT CATGGCTGAA TAGACCAATC GTGTTCCATC TACTGAGACT 1200

GGCACACTGC CTCCTGCAAT AAAACTGGGA TCCCATTACC AAGAGAGAAA TGCAGAATTG 1260

TGTACCAGTT AGCTTTTGCT GTGTAACAAA CCATCCCCAA ACTTGGCAGC TAGAAACAAA 1320

CCCTGTATTT TCCCACAATC CTATGGGTTG GCAATTTGGG CTGGGCTCAA CAGGGCAGTT 1380

CTGCTGCTCA CACCTGGGAT CCCTCATGGA GCTAAGGTCA GCTGTTACCT CAGCTGGGCC 1440

TGGATGGTCT AGGATAGCCT TACTCACTTG CCTGGCAGGT GACAGGCTGT TGGCTGGAAT 1500

TGCTTGGTTC TCCTCCATGT GGCCTCTCCA GCAGGCTAGC TCAGGCTTAT TCACATGATG 1560

GCTTCAGGAT TCCAAAGAGA GTGAGAGTAG AAGCTGAAAG ACTTCTTGAG TTCTTGGCCT 1620

GGAACTGGGA CTAGGACAGT GTCACTTCTG CTAAGTTCTT TTGGTCAGAG CAAATCACAA 1680

GGCTTTACCC AGATTCAAGG GATGAGAAAC AGACTACATG TCTTGATGAG GGGAACCACA 1740

AAGAGCTTGT GGCCATTTTT CACCTATCAC AAATAATTTT GGATGGGTAT TTATTTGGAT 1800

AAAGGTATTT CCCTCTTCCC CCTTTCTCTC TGTCTCATGG GGCCTCACTC TGCCAAGTTG 1860

GAAGGCACTA AGACATTGTC CTGGCCCTCA GGGTCTAGGG GAAGAGGTGT TGGGGCAGGA 1920

AGTGAGTCTC TCCATGGGCT GGACCCACTG TAGTAGGAGT GCCTCCTTGT CTGCACTGCT 1980

GGTATGGGGT TAGGCCAGGT AGGACATTCC AGAGGGGCTT CTGAAAACCA AGAGTCCCTG 2040

GGGAAAGGGA ACAGAGTAAG GCAGGCCTTG TTCTCACTGC CCTCTAAGGG AACTTGGTCA 2100

CTCGGCACTT TTAAGCCTCA GTTTCTCCAG TTCAATAATA AGGACAAGAG CTTTTCCCAT 2160

GCATTCTCTT TCCCCGGGAA AGTTGACTGA GGTGACCAGT AATAGAATTG AAAAGGGAGA 2220

GTGTCTTCAG TGCAATGTGG CATCCTGGAT TGGGTCTTGG AACAAAAACA GGACATTAGT 2280

GGGAAAATTG GAAATCTGAA AAAAGTCTGA ATTTTAGTTA ATATACCAAT TTCAGTCTCT 2340

TGGTTTTGAC AGATGTACCA TGGTGATGTA AGATGTTGAC CTTGGGGTAG GCTGGGTGAA 2400

GGGTATACAG GAACTCTTTG TACTATCTCT GCAACTTCTC TGTAAATCTA GTATCATTCC 2460 AAAATAAAAG TTTATTTAAT TTAAAAAAAA AAAAAAAAAA AA

Seq ID NO: 224 Protem sequence: Protein Accession ft: AAH17001.1 1 11 21 31 41 51 i ] i i i i

TLGRAGAGRG APEGPGPSGG AQGGSIHSGR IAAVHNVPLS VLIRPLPSVL DPAKVQSLVD 60 TIREDPDSVP PIDVLWIKGA QGGDYFYSFG GCHRYAAYQQ LQRETIPAKL VQSTLSDLRV 120 YLGASTPDLQ

Seq ID NO: 225 DNA sequence Nucleic Acid Accession ft: NM_021048 Coding sequence. 1..1110

1 11 21 31 41 51

I I I I I I

ATGCCTCGAG CTCCAAAGCG TCAGCGCTGC ATGCCTGAAG AAGATCTTCA ATCCCAAAGT 60

GAGACACAGG GCCTCGAGGG TGCACAGGCT CCCCTGGCTG TGGAGGAGGA TGCTTCATCA 120

TCCACTTCCA CCAGCTCCTC TTTTCCATCC TCTTTTCCCT CCTCCTCCTC TTCCTCCTCC 180

TCCTCCTGCT ATCCTCTAAT ACCAAGCACC CCAGAGGAGG TTTCTGCTGA TGATGAGACA 240

CCAAATCCTC CCCAGAGTGC TCAGATAGCC TGCTCCTCCC CCTCGGTCGT TGCTTCCCTT 300

CCATTAGATC AATCTGATGA GGGCTCCAGC AGCCAAAAGG AGGAGAGTCC AAGCACCCTA 360

CAGGTCCTGC CAGACAGTGA GTCTTTACCC AGAAGTGAGA TAGATGAAAA GGTGACTGAT 420

TTGGTGCAGT TTCTGCTCTT CAAGTATCAA ATGAAGGAGC CGATCACAAA GGCAGAAATA 480 CTGGAGAGTG TCATAAAAAA TTATGAAGAC CACTTCCCTT TGTTGTTTAG TGAAGCCTCC 540

GAGTGCATGC TGCTGGTCTT TGGCATTGAT GTAAAGGAAG TGGATCCCAC TGGCCACTCC 600

TTTGTCCTTG TCACCTCCCT GGGCCTCACC TATGATGGGA TGCTGAGTGA TGTCCAGAGC 660

ATGCCCAAGA CTGGCATTCT CATACTTATC CTAAGCATAA TCTTCATAGA GGGCTACTGC 720

ACCCCTGAGG AGGTCATCTG GGAAGCACTG AATATGATGG GGCTGTATGA TGGGATGGAG 780

CACCTCATTT ATGGGGAGCC CAGGAAGCTG CTCACCCAAG ATTGGGTGCA GGAAAACTAC 840

CTGGAGTACC GGCAGGTGCC TGGCAGTGAT CCTGCACGGT ATGAGTTTCT GTGGGGTCCA 900

AGGGCTCATG CTGAAATTAG GAAGATGAGT CTCCTGAAAT TTTTGGCCAA GGTAAATGGG 960

AGTGATCCAA GATCCTTCCC ACTGTGGTAT GAGGAGGCTT TGAAAGATGA GGAAGAGAGA 1020

GCCCAGGACA GAATTGCCAC CACAGATGAT ACTACTGCCA TGGCCAGTGC AAGTTCTAGC 1080 GCTACAGGTA GCTTCTCCTA CCCTGAATAA

Seq ID NO: 226 Protein sequence: Protein Accession ft. NP_066386

1 11 21 31 41 51

I I I I I I

MPRAPKRQRC MPEEDLQSQS ETQGLEGAQA PLAVΞEDASS STSTSSSFPS SFPSSSSSSS 60 SSCYPLIPST PEEVSADDET PNPPQSAQIA CSSPSWASL PLDQSDEGSS SQKEESPΞTL 120

QVLPDSESLP RSEIDEKVTD LVQFLLFKYQ MKEPITKAEI LESVIKNYED HFPLLFSEAS 180

ECMLLVFGID VKEVDPTGHS FVLVTSLGLT YDGMLSDVQS MPKTGILILI LSIIFIEGYC 240

TPEEVIWEAL NMMGLYDGME HLIYGEPRKL LTQDWVQENY LEYRQVPGSD PARYEFLWGP 300

5 RAHAEIRKMS LLKFLAKVNG SDPRSFPLWY EEALKDEEER AQDRIATTDD TTAMASASSS 360 ATGSFSYPE

Seq ID NO: 227 DNA sequence Nucleic Acid Accession ft: NM_005025.1 10 Coding sequence: 82-1314

1 11 21 31 41 51

I I I I I I

GCGGAGCACA GTCCGCCGAG CACAAGCTCC AGCATCCCGT CAGGGGTTGC AGGTGTGTGG 60

15 GAGGCTTGAA ACTGTTACAA TATGGCTTTC CTTGGACTCT TCTCTTTGCT GGTTCTGCAA 120

AGTATGGCTA CAGGGGCCAC TTTCCCTGAG GAAGCCATTG CTGACTTGTC AGTGAATATG 180

TATAATCGTC TTAGAGCCAC TGGTGAAGAT GAAAATATTC TCTTCTCTCC ATTGAGTATT 240

GCTCTTGCAA TGGGAATGAT GGAACTTGGG GCCCAAGGAT CTACCCAGAA AGAAATCCGC 300

CACTCAATGG GATATGACAG CCTAAAAAAT GGTGAAGAAT TTTCTTTCTT GAAGGAGTTT 360

20 TCAAACATGG TAACTGCTAA AGAGAGCCAA TATGTGATGA AAATTGCCAA TTCCTTGTTT 420

GTGCAAAATG GATTTCATGT CAATGAGGAG TTTTTGCAAA TGATGAAAAA ATATTTTAAT 480

GCAGCAGTAA ATCATGTGGA CTTCAGTCAA AATGTAGCCG TGGCCAACTA CATCAATAAG 540

TGGGTGGAGA ATAACACAAA CAATCTGGTG AAAGATTTGG TATCCCCAAG GGATTTTGAT 600

GCTGCCACTT ATCTGGCCCT CATTAATGCT GTCTATTTCA AGGGGAACTG GAAGTCGCAG 660

25 TTTAGGCCTG AAAATACTAG AACCTTTTCT TTCACTAAAG ATGATGAAAG TGAAGTCCAA 720

ATTCCAATGA TGTATCAGCA AGGAGAATTT TATTATGGGG AATTTAGTGA TGGCTCCAAT 780

GAAGCTGGTG GTATCTACCA AGTCCTAGAA ATACCATATG AAGGAGATGA AATAAGCATG 840

ATGCTGGTGC TGTCCAGACA GGAAGTTCCT CTTGCTACTC TGGAGCCATT AGTCAAAGCA 900

CAGCTGGTTG AAGAATGGGC AAACTCTGTG AAGAAGCAAA AAGTAGAAGT ATACCTGCCC 960

30 AGGTTCACAG TGGAACAGGA AATTGATTTA AAAGATGTTT TGAAGGCTCT TGGAATAACT 1020

GAAATTTTCA TCAAAGATGC AAATTTGACA GGCCTCTCTG ATAATAAGGA GATTTTTCTT 1080

TCCAAAGCAA TTCACAAGTC CTTCCTAGAG GTTAATGAAG AAGGCTCAGA AGCTGCTGCT 1140

GTCTCAGGAA TGATTGCAAT TAGTAGGATG GCTGTGCTGT ATCCTCAAGT TATTGTCGAC 1200

CATCCATTTT TCTTTCTTAT CAGAAACAGG AGAACTGGTA CAATTCTATT CATGGGACGA 1260

35 GTCATGCATC CTGAAACAAT GAACACAAGT GGACATGATT TCGAAGAACT TTAAGTTACT 1320

TTATTTGAAT AACAAGGAAA ACAGTAACTA AGCACATTAT GTTTGCAACT GGTATATATT 1380

TAGGATTTGT GTTTTACAGT ATATCTTAAG ATAATATTTA AAATACTTCC AGATAAAAAC 1440

AATATATGTA AATTATAAGT AACTTGTCAA GGAATGTTAT CAGTATTAAG CTAATGGTCC 1500 TGTTATGTCA TTGTGTTTGT GTGCTGTTGT TTAAAATAAA AGTACCTATT GAACATGTG

40

Seq ID NO: 228 Protein sequence: Protein Accession ft: NP 005016.1

. _ 1 11 21 31 41 51

45 i i i i i i

MAFLGLFSLL VLQSMATGAT FPEEAIADLS VNMYNRLRAT GEDENILFSP LSIALAMGMM 60

ELGAQGSTQK EIRHSMGYDS LKNGEEFSFL KEFSNMVTAK ESQYVMKIAN SLFVQNGFHV 120

NEEFLQMMKK YFNAAVNHVD FSQNVAVANY INKWVENNTN NLVKDLVSPR DFDAATYLAL 180

INAVYFKGNW KSQFRPENTR TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ 240

50 VLEIPYEGDE ISMMLVLSRQ EVPLATLEPL VKAQLVEEWA NSVKKQKVEV YLPRFTVEQE 300

IDLKDVLKAL GITEIFIKDA NLTGLSDNKE IFLSKAIHKS FLEVNEEGSE AAAVSGMIAI 360 SRMAVLYPQV IVDHPFFFLI RNRRTGTILF MGRVMHPETM NTSGHDFEEL

Seq ID NO: 229 DNA sequence 55 Nucleic Acid Accession ft: NM_003695 Coding sequence: 12-398

1 11 21 31 41 51

60 I I I I I I

CGACATCAGA GATGAGGACA GCATTGCTGC TCCTTGCAGC CCTGGCTGTG GCTACAGGGC 60

CAGCCCTTAC CCTGCGCTGC CACGTGTGCA CCAGCTCCAG CAACTGCAAG CATTCTGTGG 120

TCTGCCCGGC CAGCTCTCGC TTCTGCAAGA CCACGAACAC AGTGGAGCCT CTGAGGGGGA 180

ATCTGGTGAA GAAGGACTGT GCGGAGTCGT GCACACCCAG CTACACCCTG CAAGGCCAGG 240

TCAGCAGCGG CACCAGCTCC ACCCAGTGCT GCCAGGAGGA CCTGTGCAAT GAGAAGCTGC 300

65 ACAACGCTGC ACCCACCCGC ACCGCCCTCG CCCACAGTGC CCTCAGCCTG GGGCTGGCCC 360

TGAGCCTCCT GGCCGTCATC TTAGCCCCCA GCCTGTGACC TTCCCCCCAG GGAAGGCCCC 420

TCATGCCTTT CCTTCCCTTT CTCTGGGGAT TCCACACCTC TCTTCCCCAG CCGGCAACGG 480

GGGTGCCAGG AGCCCCAGGC TGAGGGCTTC CCCGAAAGTC TGGGACCAGG TCCAGGTGGG 540

CATGGAATGC TGATGACTTG GAGCAGGCCC CACAGACCCC ACAGAGGATG AAGCCACCCC 600

70 ACAGAGGATG CAGCCCCCAG CTGCATGGAA GGTGGAGGAC AGAAGCCCTG TGGATCCCCG 660

GATTTCACAC TCCTTCTGTT TTGTTGCCGT TTATTTTGTA CTCAAATCTC TACATGGAGA 720 TAAATGATTT AAACC

Seq ID NO: 230 Protein sequence:

75 Protein Accession ft: NP 003686

1 11 21 31 41 51

I I I I I I

MRTALLLLAA LAVATGPALT LRCHVCTSSS NCKHSWCPA SSRFCKTTNT VEPLRGNLVK 60 80 KDCAESCTPS YTLQGQVSSG TSSTQCCQED LCNEKLHNAA PTRTALAHSA LSLGLALSLL 120 AVILAPSL

Seq ID NO: 231 DNA sequence O Nucleic Acid Accession ft: Eos sequence Coding sequence: 126-752 31 41 51

CCGGGCAGGT GGCTCATGCT CGGGAGCGTG GTTGAGCGGC TGGCGCGGTT GTCCTGGAGC 60 AGGGGCGCAG GAATTCTGAT GTGAAACTAA CAGTCTGTGA GCCCTGGAAC CTCCACTCAG 120 AGAAGATGAA GGATATCGAC ATAGGAAAAG AGTATATCAT CCCCAGTCCT GGGTATAGAA 180 GTGTGAGGGA GAGAACCAGC ACTTCTGGGA CGCACAGAGA CCGTGAAGAT TCCAAGTTCA 240 GGAGAACTCG ACCGTTGGAA TGCCAAGATG CCTTGGAAAC AGCAGCCCGA GCCGAGGGCC 300 TCTCTCTTGA TGCCTCCATG CATTCTCAGC TCAGAATCCT GGATGAGGAG CATCCCAAGG 360 GAAAGTACCA TCATGGCTTG AGTGCTCTGA AGCCCATCCG GACTACTTCC AAACACCAGC 420 ACCCAGTGGA CAATGCTGGG CTTTTTTCCT GTATGACTTT TTCGTGGCTT TCTTCTCTGG 480 CCCGTGTGGC CCACAAGAAG GGGGAGCTCT CAATGGAAGA CGTGTGGTCT CTGTCCAAGC 540 ACGAGTCTTC TGACGTGAAC TGCAGAAGAC TAGAGAGACT GTGGCAAGAA GAGCTGAATG 600 AAGTTGGGCC AGACGCTGCT TCCCTGCGAA GGGTTGTGTG GATCTTCTGC CGCACCAGGC 660 TCATCCTGTC CATCGTGTGC CTGATGATCA CGCAGCTGGC TGGCTTCAGT GGACCAAATT 720 TTCAGGATGG CTGTATTCTG CGGTCAGAAT GAGAGAGTCA AGCTGGGCAG AATCTCTCGC 780 CAAGAGTTCA GCCTTCCTTT GGAGACTGCT CCATCAGTGC CGAGGTGTGT GGGAACAGGC 840 TTCACTGCAC CGCCATCTTA CTGAGTTGCT TCACGTGAGG AAAAGGGGGC TTTGGCCCTG 900 TGACTCAGTT CCACATTTTG GATTGCATAC TGGAAAAGAA GCCAATCTTC TTGCTAGTAA 960 ACCAGCAACC CGGCTGTATA CAGTGGTGAC CCAAGCAATG GATATAAACC TAAAAATCTG 1020 AGGGAGGGGA GAGGTGGAAT ACAGTAGTTC TTGGAATCTG AAGTCTCCTA TTTGATCAGG 1080 TTATTTCCTG GGACTTGGCA AAAATCTGAT TGGTGGGGAT CTCCTAGGAC CTAGTGGACA 1140 TCTGGTATTA ATTTAATCTC AGGAAAAACA AGAAATTAAC CCAGAGAGAG TCTGGGTTTT 1200 GGAATTCAGC GTAGCTACCT CCAGACCGTG GTGTCTGGCC TCCATTTTTG TCTGTCATTC 1260 AGCTCTGACT TACAGCTGCA GTCACCTTTG CTATAAGGCA CCTGGGTAGA AGGGTGGATG 1320 GGCTTCACAT CAATTTTTTT CTTCCTTTAG GGTGGGGGAT TGGTTTGGCT TTCTTTTGTT 1380 GTGGTTTTTT GTTTTATTTT TGTCAAGATT GATTTTTAGA TGCAAGGACT TGAAAAGACC 1440 CAGAAGGATG CCACCAGTTT TTCCTTGAGG CCTAGGATTT TTTATTCTGT CCCGAGCAGA 1500 GGTAATTCCT CACAACTTAG TGCACCAGTA GCACCAGCCA TTTTGAGCAG AGTACCTCTT 1560 TGGGGAGCTT TTCGTTTTGT TTTGTTTTTA ATTCTCTTTC CTTAGCAGCA AGGTCTTTTT 1620 TCCTAGAGAA TCTACTCCGT TGCAGAATCA TTGCAACCTC AGGAGCCCTC ACTGATTGAG 1680 TGCTGTCAGC CTGATATACT ACTTTGGACT CTGGAAACAG ATATGGGTTC TATTCTCTAT 1740 TTCTACTGTG TGTCGTTAAA CAACCGTCGG AGACCAGATG ACCTGTTAGA TGGCTAGTCC 1800 TGTATAACTC GACTCTGTAT GTTTCAATGT ATGTTACTGC AATGCTTCAC CTGCTGTACA 1860 GTGTTTGTGA GATGCTCTTT GAAGATGGTA CTTTTATATT T

Seq ID NO: 232 Protein sequence: Protein Accession ft : Eos sequence

11 21 31 41 51

MKDIDIGKEY IIPSPGYRSV R IERTSTSGTH RDREDSKFRR TRPLECQDAL ETAARAEGLS 60 LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP VDNAGLFSCM TFSWLSSLAR 120 VAHKKGELSM EDVWSLSKHE SSDVNCRRLE RLWQEELNEV GPDAASLRRV VWIFCRTRLI 180 LSIVCLMITQ LAGFSGPNFQ DGCILRSE

Seq ID NO: 233 DNA sequence

Nucleic Acid Accession ft: CAT cluster

11 21 31 41 51

I I I I

TTTTAATGGT GCTCATATAT ACTGTATTTT TTGTTGTTTA GTTTTACTTA TTGAGAGTGT 60 CACAACATGA ATCACATAAT CATGATTTTT TTTTTTTACT TTTACTCCCC AAATTATTCA 120 TGTTTCTTAG ATCGTAGTCA TTGAGAAGTC CCAATAACTC TAAACTTTTG AGTTATAACG 180 TAGTAAACTT CTCTTTCATC TTTGTGTTAG CTCTGTAGTC TTAACCTGGA TTTTAATTTT 240 TTTGTTTCCA AAGTCACAAT TGAATTATTC TTAGATACCT TAAGCCACTG AATTCAGTTC 300 TGTTTGACTG AAAGCAAAAC AACGTGACAG TTTATTTTCA AACACTAACT TCTTGATATT 360 TTGTTATGGT ATATCTTTTT ATTAAATATT TATTTTGACT AAGCTTTCAT AAAATATTTG 420 AAGCTATTTT AATCATCAAG TATGGAAAAC AAATTACTAT TGCATTTTCC TATATATGCA 480 TATATTATGG ATTAACCAGA ATTGTATCAT TTTTGGCCTA ATGTCTGGAT ATAAAAGATA 540 ATTAGCCTAC TATAGTATTA ATAAATTTTT CAGTTGGTTT GGGCAAATTT AAACCTGAAA 600 AATAGGTTAA AAAGTAGTTA CAAATTAAAC TTACTAATTT ATACCTGATT TTTTTTCTTG 660 AATTAAAGTA CATTTTAAAT GAGCTTTATA ATACCTTAAA AAGTTGGTTC TAATTTAAAA 720 TATGAAAGCT CTGGCTATCA TCCTGGGATA GTAATTTCTA ATTATATAGT ATTTCAAAAC 780 TATATATTTT TTAGTTCCTT TGAGATAACT AATTTCTAAT TATATATGTT TCAAAAACCA 840 TATCCTGTAT TTTTTTTAAG AATTGTTTTA TAAATAGGTC ATAAGATACA AGGTCTGCAT 900 TAGAAGACCC ACTCTTACTA GGTTCCCTAA GGATCTGCCA TAGATTTTTT 960 TTTTTTTTAG GTAGTTTAAA GCAAGCACTG ATACCAGTGG GAGTTGGTCT TGATCTAGGA 1020 GATTCTGTTA AGCATCCAAA AACAATGCCT AATTTCAGTT CTTAGGTTAT GGCTTGTGAC 1080 TCCAGATAAA AGATGGAGAA TACCTCATGT ACTGTGACTT GAAAATGAAT TCTTAAAATT 1140 CTTAGGCTCT CTCCATGTAT CTTTCTTAAG GAAAAGTTTC TGAGTGTGAT CTCTCTTTTG 1200 CCATAGTATC AAGTGGAGGG TAGTTCAGAA AAGTTAATAG GAAATCTTTT GTGACAGCAG 1260 ACTATAATAG AAGTTTGAGT AATATTTTAA TAAATTTATA TAATTCAAAT GATAAAAATG 1320 TATCAATGTT ATCCAATGAT TTTTATTAAA AAATTACCTT ATTATTAGAA CTGTGCCTAT 1380 TACATAAAAA GTGCTCATGT ATTTGAATTT TAAATAATTT ATTTAAATCA AGACCACCAT 1440 AAGTCATTAA TAATTTAATA ATTGTTTTAA ATCAGTGGTT TTCAACCCTC ACTTCATATT 1500 AGAATCATCT GAGGACTTTT AATATGGAAT CCACCTCATA ACAATTAAGT CTAAATTTCT 1560 GGAAGATGGA GCCATGCTTG TTTTTCCAAA AGCTCTTTGA GTGATTCTAA TTTGTAGTCA 1620 GAGTTGAAGA CCACTGCTCT AAATTAGTGC AGGAAAATGC TTTTATTTCT CCCATGTTAA 1680 CTTTTAAAAC TAGTAATGTA CCCAGTTAAG TTTTGATGGT TTAAATTCCA CTAAAGAACA 1740 TATTCTTCTA ATAACTAGCA TTTATTACAT GAAATTTAAG AGTTTAAGTT CCATCAAACT 1800 AGCCCTTGTG TAAGATTATT ATTTCTTCTC TATAACTTCA AAATAGATAT TTCATTCAAA 1860 CTGTTCAGGT GAGAAAACAT AATGGATTTT CTCTGGAGCT GCCTGTTCAG 1920 TGAGATGGAG GAGGTGGGCA CATTTAAGGT CAGTTCACTA ACCTATGGTT CAGAGTTCTG 1980 ATCATATGGA AGTTTGGAAA AGAGAGCTTA TCACAGGTTT GTATGCTGGT GAATGGATAG 2040 TTTTAATTCT CACTGTCTCA AAAGAGAATC AGCTCTCCAG CAGTTCTAGA AAAGCTTTGA 2100 CAATCCCCAA GGGGCAGTGT TACCTTACTC CTTCACTGCT TCTTAGAAGG TAGAATTAAG 2160 TTTCTGGAAT TGCACCTACA TGTTTTCTTA TTAACATTCA GAATTGGGAA TATTAATTTT 2220 TCCAGTGAGT AGTTTTCTGA AATTGGTAAC TTGGAGAGTA AAATAACGTA TTTTGCTTTT 2280

CAATTTTGTG TTTGTTTACT TTTATGTAAA AATTTGATAT GTGAATTACA CAGTTCTAAT 2340

AAAACCTCAT GCCTTTTCAT TACATCTAAT TTGAACTCTC AACTTCAGTG CCAGAAGTGC 2400

TTTAAAGATG CTTTAATGAA AAGTATTAAG AAAATATATA GATTTGTATG TCAGTTTATA 2460

CTTCAGAAAT CCATATATTT GTCATATTTA TTTTTTTAGA AACCTCCTAA TTGGATAACT 2520

AGATGGTATT TAAAATGAAT GCCCAAAAAT ATCTTGTACC TTTGTCCAAA AGTTTATCTG 2580

TTGGAAGCCG CCAGCCATTC ATGTAGAGAG TTTATAAGAA AATAATTTAA AATTGTATGC 2640

ATTTTATATT ACTATGGTAT CTGTGTACCA TATTTCTAAG TATTCATTAT TAAATTGGTA 2700

CTTCTTAAAA CCATAACCTG GCTTGCCTTT TAGTGTTAAA CACAAAATCC AACATTGTAT 2760

ATAGAGATTC TTCTTTTATG AAGAAGAGCT GACGTAATTT ATTACCAGTG CATCTGCACA 2820

AAGACATTAA CATAAGTCTC TGAGCAGTGA TACATTTTCA AACATGAAGA GTGACAACCA 2880

CCACATTAAA CAACCACGGC AACACTCAGA CTTGGCACTT TCCTACGAAT CCATCCTATA 2940

TGTGCCTGGT ATCGCCTCTG GCATAACTTA CACGAATCGT CCTCCCTACT TGTCTACGCT 3000

CCTTCATCAA GCACTTGCCA ACACATTCAC CTCTAACTTG TACAACCTTA CCAACTCACC 3060

ACAACATCTG CAACTCTACC CTATCAACTG CCAACCTAAA GACCCCCAAC ACAACACAAC 3120

CCCCAAACAC AAAACCACTA AATCATAACC ACCACACACG CCACACACCA CACACCCACC 3180

CACACAACCA ACACACCACG ACCAAACACC CCACCACAAA CAAGCTAACA ACCACAAACA , 3240 GACAACACAT CACATACACT CACTACCCCC CCATACTCCC ACCCACCA Seq ID NO: 234 DNA sequence

Nucleic Acid Accession ft: Eos sequence Coding sequence: 27-281 1 11 21 31 41 51 i i i i i i

AGCAGGAGGA GAGCTGGCGG GAAGACATGC ACCCCTTGAA GACCCAGAGA GAGGCCGTCT 60

GTCTACCGCG TAGCAGTTAC ATCAGACTGA GACACTTCCT GTTTACAGGA GACTATAAAA 120

TTCCTGCCCC GTGCTCATTT GGGGCTGACG CCATTTTAGG CCTCAGCCCA TCTGCACCCA 180

GGCGCTCACT GAAACAGTGT GTTGCTCCAC ACCGCCTTGT TTTGCTTGTT GGCGCGCTCT 240

CAGGGTTCCG ACCAATCCAA GAGCCTTGCA GAAAGCATTA ACGTGCTTTT CTCTTTGGCA 300

GAGTTTTTCT TTGCTCTGAT CTTGGAGACA TCCCTCTGCC TAGTGGAAAC ATAAGGAATA 360

CAGAAAGAAT GCAAGGAGAT AGACCAACGT GAGATTCTCC TTCATGCACT CAAGAGAAAG 420

ATGTTGCAGG AAGAGCTAGT CTTTCAGGCT GGGCTGGTGA CCTGAGAAAG AATGTCCAGC 480

TTTTCTTCTC CACTTGGCAT ATCAAGAGCC AGGCGTGGAA GACTAAAACA GGAAATGTTT 540

ATAAAAACTG TTCAGCGGTT CGCCAACAAG AAGTGGTAAA GTAGCAAAAA TGGGGATGGA 600

GATGCCAGGA GGAAAGATGC CAGGGGTAAA GTGGGAAAAT GGGAACCTGA AGCCAGGAGG 660

TCAAGCCAAG CCAACAGGTG TTCTGTTTTT CATCACAGAA CTAATAAGTG GTGCTGAGGA 720

CTCAAACCCG GGGAAGCCCA CTCTAGAACC CATGCTGGTC ATCCATATCC CCAAGGCCCT 780

GGTCAGAACA CAGCTAAGCA GATGGCTTGG GTCATCAGGA CGTCCATTAC ATCCAAAGGA 840

AGACAGCCTG TGACGTTTCA AAAGCAAAAG TCCCCTACCA GCCAGTGAAG CTACCTGATT 900

TCTCAGTATC TTACGCCCAG TGACACGATC TACCCTCAAA ACTTAAAAAA AAAAGGGAAA 960

CATAAACACA TAACAGCAGC AGCAATAATT AAAGATGAGA TGAGAACAAT TAAGAAAAAA 1020

GGAAAGGTCT CCTGTGACTG TTTTATTTTT AGGGAAACAG AGAGGAAGAA GAATGATTTT 1080

TCTTTTGATG ACTCTATATC CAACTCTGAG GTTTGATTAA AGAAATGACC TTGAACCACA 1140

GCAAAGAAAA ATAAAAGACA ATTTCCAGTA AGTATGCCAG TTCGAATTAA TGATTTACTT 1200

TTTATTTTTA AACTGAATTC AGCAGAGATT TACATGCATT ACGATGATTA ACATCTGAAA 1260

TTTGACCTTG AAATAATCTT TACATTGTAA ATTCTTAATG ATCAAAACAA GGTTCTCAGT 1320

GATTAAAACA TATTAGTAAT TAATTATTAA AGGAGAATAA TTGCAAATAC AACATTCCTA 1380

AAATCTCAAG GCTTTTAAAG CATTTGTACA AATGACTGGA CATTTTTTAA ATTTGAAAAA 1440

AAAAAAAAGC CCTCCATCTG ATTCTCATTT TCATTGTCAG TGCAACAACA AAAAAGGTAT 1500

GCACTTCTCT TCTCATTTTC CACTGTCTCG CAAGCTAGAA ATTCTCACGA CTACCTTTGA 1560

TCCCATCAAA GCCAAAGAAA GAAAAGAAAA TTGTTCTGTA CAGATATATG ACATTAAAAA 1620 ATAATCCC

Seq ID NO: 235 Protein sequence: Protein Accession ft: Eos sequence

41

MHPLKTQREA VCLPRSSYIR LRHFLFTGDY KIPAPCSFGA DAILGLSPSA PRRSLKQCVA 60 PHRLVLLVGA LSGFRPIQEP CRKH

Seq ID NO: 236 DNA sequence Nucleic Acid Accession ft: NM_002075 Coding sequence: 406..1428

1 11 21 31 41 51

I I I I I I

CCACAATAGG GGCAGACCTG TCCATCCTTC TCTGTGGGTC CCCTGTACCT TTCTCCCCCA 60

ACAGGATCAG ACCCAGAGGC AGCTGGTTGG GGTTTGTCGA GAAGAAGGAT TATCCAGATC 120

AGTCCTTTCT AATCTCAGCT CCTGCCTGTA CCCTCCCATA CTCACCAAAC CCTCTTCCCC 180

ACCACCCTGA GCTGAGGAGC ACAGTTTGAG GCCCCCCCAA CCCCCCGCCG GTCGGGGCCA 240

GGCCAGGCCA GGCCAGCTCC TCTGGCAGCA GAGCCTGGGC AGGTGACGGG CGGGCGCGGG 300

CGTCGCAGCT GAGGGAGTAA GGAGGCTCCC AGGAACCGGA GCTGGAAACC CGGCCGAGGT 360

CCAGCCAGAG CCCAAGAGCC AGAGTGACCC CTCGACCTGT CAGCCATGGG GGAGATGGAG 420

CAACTGCGTC AGGAAGCGGA GCAGCTCAAG AAGCAGATTG CAGATGCCAG GAAAGCCTGT 480

GCTGACGTTA CTCTGGCAGA GCTGGTGTCT GGCCTAGAGG TGGTGGGACG AGTCCAGATG 540

CGGACGCGGC GGACGTTAAG GGGACACCTG GCCAAGATTT ACGCCATGCA CTGGGCCACT 600

GATTCTAAGC TGCTGGTAAG TGCCTCGCAA GATGGGAAGC TGATCGTGTG GGACAGCTAC 660

ACCACCAACA AGGTGCACGC CATCCCACTβ CGCTCCTCCT GGGTCATGAC CTGTGCCTAT 720

GCCCCATCAG GGAACTTTGT GGCATGTGGG GGGCTGGACA ACATGTGTTC CATCTACAAC 780

CTCAAATCCC GTGAGGGCAA TGTCAAGGTC AGCCGGGAGC TTTCTGCTCA CACAGGTTAT 840

CTCTCCTGCT GCCGCTTCCT GGATGACAAC AATATTGTGA CCAGCTCGGG GGACACCACG 900

TGTGCCTTGT GGGACATTGA GACTGGGCAG CAGAAGACTG TATTTGTGGG ACACACGGGT 960

GACTGCATGA GCCTGGCTGT GTCTCCTGAC TTCAATCTCT TCATTTCGGG GGCCTGTGAT 1020

GCCAGTGCCA AGCTCTGGGA TGTGCGAGAG GGGACCTGCC GTCAGACTTT CACTGGCCAC 1080 GAGTCGGACA TCAACGCCAT CTGTTTCTTC CCCAATGGAG AGGCCATCTG CACGGGCTCG 1140

GATGACGCTT CCTGCCGCTT GTTTGACCTG CGGGCAGACC AGGAGCTGAT CTGCTTCTCC 1200

CACGAGAGCA TCATCTGCGG CATCACGTCC GTGGCCTTCT CCCTCAGTGG CCGCCTACTA 1260

TTCGCTGGCT ACGACGACTT CAACTGCAAT GTCTGGGACT CCATGAAGTC TGAGCGTGTG 1320

GGCATCCTCT CTGGCCACGA TAACAGGGTG AGCTGCCTGG GAGTCACAGC TGACGGGATG 1380

GCTGTGGCCA CAGGTTCCTG GGACAGCTTC CTCAAAATCT GGAACTGAGG AGGCTGGAGA 1440

AAGGGAAGTG GAAGGCAGTG AACACACTCA GCAGCCCCCT GCCCGACCCC ATCTCATTCA 1500

GGTGTTCTCT TCTATATTCC GGGTGCCATT CCCACTAAGC TTTCTCCTTT GAGGGCAGTG 1560

GGGAGCATGG GACTGTGCCT TTGGGAGGCA GCATCAGGGA CACAGGGGCA AAGAACTGCC 1620

CCATCTCCTC CCATGGCCTT CCCTCCCCAC AGTCCTCACA GCCTCTCCCT TAATGAGCAA 1680

GGACAACCTG CCCCTCCCCA GCCCTTTGCA GGCCCAGCAG ACTTGAGTCT GAGGCCCCAG 1740

GCCCTAGGAT TCCTCCCCCA GAGCCACTAC CTTTGTCCAG GCCTGGGTGG TATAGGGCGT 1800

TTGGCCCTGT GACTATGGCT CTGGCACCAC TAGGGTCCTG GCCCTCTTCT TATTCATGCT 1860

TTCTCCTTTT TCTACCTTTT TTTCTCTCCT AAGACACCTG CAATAAAGTG TAGCACCCTG 1920 GT

Seq ID NO: 237 Protein sequence: Protein Accession ft: NP_002066

1 11 21 31 41 51

I I I I I I

MGEMEQLRQE AEQLKKQIAD ARKACADVTL AELVSGLEW GRVQMRTRRT LRGHLAKIYA 60

MHWATDSKLL VSASQDGKLI VWDSYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNM 120

CSIYNLKSRE GNVKVSRELS AHTGYLSCCR FLDDNNIVTS SGDTTCALWD IETGQQKTVF 180

VGHTGDCMSL AVSPDFNLFI SGACDASAKL WDVREGTCRQ TFTGHESDIN AICFFPNGEA 240

ICTGSDDASC RLFDLRADQE LICFSHESII CGITSVAFSL SGRLLFAGYD DFNCNVWDSM 300 KSERVGILSG HDNRVSCLGV TADGMAVATG SWDSFLKIWN

Seq ID NO: 238 DNA sequence Nucleic Acid Accession ft: CAT cluster

1 11 21 31 41 51

T ICCCAATGTG TINGAACCTAC CIATAAATTCT TITTCTTACNG GIACAATCTTA TINCTAANCAA 60

TACCATTTGC TTTTAAGGCA GATAATCCTC CAAGTTTTCT AATGATATCT GAAACTATTA 120

ACTGATTCTG TGAATTATGA AATCTGAAAA GGAATTGGAA GTTGCTAAAA ATCTATCATT 180

TGCATTGACC AGTGTGAAGC ACAGTGGAAT GAGAATGCGT GCCCTGACAC CAAAGAAAAA 240

TAAGTGACTG GAAAGCTGAA GAATCACCGG CTTCAGTGAC ATGGAACCCA GTGATTTGAT 300

TTTTGACGAG TATCGGGTGA CTTTGAGGTG GTCAAGAAAC CACACTTTAA GAACAATGTC 360

CAAAAAGGGG AAAAAAAAGA GCAACCAAAG AAAAAAAATC CATAAAATTG CACAGAAGAA 420

AAGAAAGAAA AATAAAATAC ACAATATGGA CGATGGAGAA AAACAGTTAC ATTTCTTTAT 480

GGATCAAGAA GTTTGTGTAC ACATAATCTC ATTTTGAGAT ATATAACTAT TTTTGTCTTT 540

CAGAAGTGAA TCAAAATATT TCAAAATGCT GTCTTATGAA ACTACAATAT TCTCACAGAT 600

TAGAAAAGTT TTTCTGTAAA AGTCAGATAG TAAATATTTT AGGTTTTGCA GTGTCTTTTG 660

CAACTACTCA ACTTTCCTAC TGTAGCACAA GAGTAGCTGT GGTACTGTGC AAATAAATTG 720

CTTGTGTTCC AATAAAGCTT CATTTACAAA AACATGCCAT GGGCCATATT TGGCCTGTAC 780

ACTGTTGTTT GCCAAGTCCT AATATAGTTG CTTAGCAAGT ATTGTGAGCT ATTTGAGGAA 840

GACATGAAAG TTCATTGGGT TGCTAAAAAG TATGTAGAAA TTCAAAGGAA AATTAAAATT 900

TAGGCTAAGT TATAATACAC TGTTTTAACA ATTGTAAAAT GTAAGAGAAA TTTACAAATA 960 AAAATCCCAA ATAAAA

Seq ID NO: 239 DNA sequence

Nucleic Acid Accession ft: NM_001786.1

Coding sequence: 130-1023

1 11 21 31 41 ■ 51

I I I I I I

GGGGGGGGGG GGCACTTGGC TTCAAAGCTG GCTCTTGGAA ATTGAGCGGA GAGCGACGCG 60

GTTGTTGTAG CTGCCGCTGC GGCCGCCGCG GAATAATAAG CCGGGATCTA CCATACCCAT 120

TGACTAACTA TGGAAGATTA TACCAAAATA GAGAAAATTG GAGAAGGTAC CTATGGAGTT 180

GTGTATAAGG GTAGACACAA AACTACAGGT CAAGTGGTAG CCATGAAAAA AATCAGACTA 240

GAAAGTGAAG AGGAAGGGGT TCCTAGTACT GCAATTCGGG AAATTTCTCT ATTAAAGGAA 300

CTTCGTCATC CAAATATAGT CAGTCTTCAG GATGTGCTTA TGCAGGATTC CAGGTTATAT 360

CTCATCTTTG AGTTTCTTTC CATGGATCTG AAGAAATACT TGGATTCTAT CCCTCCTGGT 420

CAGTACATGG ATTCTTCACT TGTTAAGAGT TATTTATACC AAATCCTACA GGGGATTGTG 480

TTTTGTCACT CTAGAAGAGT TCTTCACAGA GACTTAAAAC CTCAAAATCT CTTGATTGAT 540

GACAAAGGAA CAATTAAACT GGCTGATTTT GGCCTTGCCA GAGCTTTTGG AATACCTATC 600

AGAGTATATA CACATGAGGT AGTAACACTC TGGTACAGAT CTCCAGAAGT ATTGCTGGGG 660

TCAGCTCGTT ACTCAACTCC AGTTGACATT TGGAGTATAG GCACCATATT TGCTGAACTA 720

GCAACTAAGA AACCACTTTT CCATGGGGAT TCAGAAATTG ATCAACTCTT CAGGATTTTC 780

AGAGCTTTGG GCACTCCCAA TAATGAAGTG TGGCCAGAAG TGGAATCTTT ACAGGACTAT 840

AAGAATACAT TTCCCAAATG GAAACCAGGA AGCCTAGCAT CCCATGTCAA AAACTTGGAT 900

GAAAATGGCT TGGATTTGCT CTCGAAAATG TTAATCTATG ATCCAGCCAA ACGAATTTCT 960

GGCAAAATGG CACTGAATCA TCCATATTTT AATGATTTGG ACAATCAGAT TAAGAAGATG 1020

TAGCTTTCTG ACAAAAAGTT TCCATATGTT ATGTCAACAG ATAGTTGTGT TTTTATTGTT 1080

AACTCTTGTC TATTTTTGTC TTATATATAT TTCTTTGTTA TCAAACTTCA GCTGTACTTC 1140

GTCTTCTAAT TTCAAAAATA TAACTTAAAA ATGTAAATAT TCTATATGAA TTTAAATATA 1200 ATTCTGTAAA TGTGAAAAAA AAAAAAAAAA AAAAA

Seq ID NO: 240 Protein sequence: Protein Accession ft: NP_001777.1

1 11 21 31 41 51 i i i i I I

MEDYTKIEKI GEGTYG YK GRHKTTGQW AMKKIRLESE EEGVPSTAIR EISLLKELRH 60 PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM DSSLVKSYLY QILQGIVFCH 120 SRRVLHRDLK PQNLLIDDKG TIKLADFGLA RAFGIPIRVY THEWTLWYR SPEVLLGSAR 180 YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT 240 FPKWKPGSLA SHVKNLDENG LDLLSKMLIY DPAKRISGKM ALNHPYFNDL DNQIKKM

Seq ID NO : 241 DNA sequence

Nucleic Acid Accession ft : NM_033379 .1

Coding sequence : 132-854

1 11 21 31 41 51

I I I I I I

CGCCCGCGCG CGGGCTCAAC TTTGTAGAGC GAGGGGCCAA CTTGGCAGAG CGCGCGGCCA 60

GCTTTGCAGA GAGCGCCCTC CAGGGACTAT GCGTGCGGGG ACACGGGATC TACCCATACC 120

ATTGACTAAC TATGGAAGAT TATACCAAAA TAGAGAAAAT TGGAGAAGGT ACCTATGGAG 180

TTGTGTATAA GGGTAGACAC AAAACTACAG GTCAAGTGGT AGCCATGAAA AAAATCAGAC 240

TAGAAAGTGA AGAGGAAGGG GTTCCTAGTA CTGCAATTCG GGAAATTTCT CTATTAAAGG 300

AACTTCGTCA TCCAAATATA GTCAGTCTTC AGGATGTGCT TATGCAGGAT TCCAGGTTAT 360

ATCTCATCTT TGAGTTTCTT TCCATGGATC TGAAGAAATA CTTGGATTCT ATCCCTCCTG 420

GTCAGTACAT GGATTCTTCA CTTGTTAAGG TAGTAACACT CTGGTACAGA TCTCCAGAAG 480

TATTGCTGGG GTCAGCTCGT TACTCAACTC CAGTTGACAT TTGGAGTATA GGCACCATAT 540

TTGCTGAACT AGCAACTAAG AAACCACTTT TCCATGGGGA TTCAGAAATT GATCAACTCT 600

TCAGGATTTT CAGAGCTTTG GGCACTCCCA ATAATGAAGT GTGGCCAGAA GTGGAATCTT 660

TACAGGACTA TAAGAATACA TTTCCCAAAT GGAAACCAGG AAGCCTAGCA TCCCATGTCA 720

AAAACTTGGA TGAAAATGGC TTGGATTTGC TCTCGAAAAT GTTAATCTAT GATCCAGCCA 780

AACGAATTTC TGGCAAAATG GCACTGAATC ATCCATATTT TAATGATTTG GACAATCAGA 840

TTAAGAAGAT GTAGCTTTCT GACAAAAAGT TTCCATATGT TATGTCAACA GATAGTTGTG 900

TTTTTATTGT TAACTCTTGT CTATTTTTGT CTTATATATA TTTCTTTGTT ATCAAACTTC 960

AGCTGTACTT CGTCTTCTAA TTTCAAAAAT ATAACTTAAA AATGTAAATA TTCTATATGA 1020 ATTTAAATAT AATTCTGTAA ATGTGAAAAA AAAAAAAAAA AAAAAA

Seq ID NO: 242 Protem sequence: Protein Accession ft: NP 203698.1

1 11 21 31 41 51 i i i i i i

MEDYTKIEKI GEGTYGWYK GRHKTTGQW AMKKIRLESE EEGVPSTAIR EISLLKELRH 60

PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM DSSLVKWTL WYRSPEVLLG 120

SARYSTPVDI WSIGTIFAEL ATKKPLFHGD SEIDQLFRIF RALGTPNNEV WPEVESLQDY 180 KNTFPKWKPG SLASHVKNLD ENGLDLLSKM LIYDPAKRIS GKMALNHPYF NDLDNQIKKM

Seq ID NO: 243 DNA sequence

Nucleic Acid Accession ft: AF101051.

Coding sequence: 221-856

1 11 21 31 41 51

I I I I I I

GAGCAACCTC AGCTTCTAGT ATCCAGACTC CAGCGCCGCC CCGGGCGCGG ACCCCAACCC 60

CGACCCAGAG CTTCTCCAGC GGCGGCGCAG CGAGCAGGGC TCCCCGCCTT AACTTCCTCC 120

GCGGGGCCCA GCCACCTTCG GGAGTCCGGG TTGCCCACCT GCAAACTCTC CGCCTTCTGC 180

ACCTGCCACC CCTGAGCCAG CGCGGGCGCC CGAGCGAGTC ATGGCCAACG CGGGGCTGCA 240

GCTGTTGGGC TTCATTCTCG CCTTCCTGGG ATGGATCGGC GCCATCGTCA GCACTGCCCT 300

GCCCCAGTGG AGGATTTACT CCTATGCCGG CGACAACATC GTGACCGCCC AGGCCATGTA 360

CGAGGGGCTG TGGATGTCCT GCGTGTCGCA GAGCACCGGG CAGATCCAGT GCAAAGTCTT 420

TGACTCCTTG CTGAATCTGA GCAGCACATT GCAAGCAACC CGTGCCTTGA TGGTGGTTGG 480

CATCCTCCTG GGAGTGATAG CAATCTTTGT GGCCACCGTT GGCATGAAGT GTATGAAGTG 540

CTTGGAAGAC GATGAGGTGC AGAAGATGAG GATGGCTGTC ATTGGGGGTG CGATATTTCT 600

TCTTGCAGGT CTGGCTATTT TAGTTGCCAC AGCATGGTAT GGCAATAGAA TCGTTCAAGA 660

ATTCTATGAC CCTATGACCC CAGTCAATGC CAGGTACGAA TTTGGTCAGG CTCTCTTCAC 720

TGGCTGGGCT GCTGCTTCTC TCTGCCTTCT GGGAGGTGCC CTACTTTGCT GTTCCTGTCC 780

CCGAAAAACA ACCTCTTACC CAACACCAAG GCCCTATCCA AAACCTGCAC CTTCCAGCGG 840

GAAAGACTAC GTGTGACACA GAGGCAAAAG GAGAAAATCA TGTTGAAACA AACCGAAAAT 900

GGACATTGAG ATACTATCAT TAACATTAGG ACCTTAGAAT TTTGGGTATT GTAATCTGAA 960

GTATGGTATT ACAAAACAAA CAAACAAACA AAAAACCCAT GTGTTAAAAT ACTCAGTGCT 1020

AAACATGGCT TAATCTTATT TTATCTTCTT TCCTCAATAT AGGAGGGAAG ATTTTACCAT 1080

TTGTATTACT GCTTCCCATT GAGTAATCAT ACTCAAATGG GGGAAGGGGT GCTCCTTAAA 1140

TATATATAGA TATGTATATA TACATGTTTT TCTATTAAAA ATAGACAGTA AAATACTATT 1200

CTCATTATGT TGATACTAGC ATACTTAAAA TATCTCTAAA ATAGGTAAAT GTATTTAATT 1260

CCATATTGAT GAAGATGTTT ATTGGTATAT TTTCTTTTTC GTCCTTATAT ACATATGTAA 1320

CAGTCAAATA TCATTTACTC TTCTTCATTA GCTTTGGGTG CCTTTGCCAC AAGACCTAGC 1380 CTAATTTACC AAGGATGAAT TCTTTCAATT CTTCATGCGT GCCCTTTTCA TATACTTATT 1440

TTATTTTTTA CCATAATCTT ATAGCACTTG CATCGTTATT AAGCCCTTAT TTGTTTTGTG 1500

TTTCATTGGT CTCTATCTCC TGAATCTAAC ACATTTCATA GCCTACATTT TAGTTTCTAA 1560

AGCCAAGAAG AATTTATTAC AAATCAGAAC TTTGGAGGCA AATCTTTCTG CATGACCAAA 1620

GTGATAAATT CCTGTTGACC TTCCCACACA ATCCCTGTAC TCTGACCCAT AGCACTCTTG 1680

TTTGCTTTGA AAATATTTGT CCAATTGAGT AGCTGCATGC TGTTCCCCCA GGTGTTGTAA 1740

CACAACTTTA TTGATTGAAT TTTTAAGCTA CTTATTCATA GTTTTATATC CCCCTAAACT 1800

ACCTTTTTGT TCCCCATTCC TTAATTGTAT TGTTTTCCCA AGTGTAATTA TCATGCGTTT 1860

TATATCTTCC TAATAAGGTG TGGTCTGTTT GTCTGAACAA AGTGCTAGAC TTTCTGGAGT 1920

GATAATCTGG TGACAAATAT TCTCTCTGTA GCTGTAAGCA AGTCACTTAA TCTTTCTACC 1980

TCTTTTTTCT ATCTGCCAAA TTGAGATAAT GATACTTAAC CAGTTAGAAG AGGTAGTGTG 2040

AATATTAATT AGTTTATATT ACTCTCATTC TTTGAACATG AACTATGCCT ATGTAGTGTC 2100

TTTATTTGCT CAGCTGGCTG AGACACTGAA GAAGTCACTG AACAAAACCT ACACACGTAC 2160

CTTCATGTGA TTCACTGCCT TCCTCTCTCT ACCAGTCTAT TTCCACTGAA CAAAACCTAC 2220

ACACATACCT TCATGTGGTT CAGTGCCTTC CTCTCTCTAC CAGTCTATTT CCACTGAACA 2280 AAACCTACGC ACATACCTTC ATGTGGCTCA GTGCCTTCCT CTCTCTACCA GTCTATTTCC 2340

ATTCTTTCAG CTGTGTCTGA CATGTTTGTG CTCTGTTCCA TTTTAACAAC TGCTCTTACT 2400

TTTCCAGTCT GTACAGAATG CTATTTCACT TGAGCAAGAT GATGTATGGA AAGGGTGTTG 2460 GCACTGGTGT CTGGAGACCT GGATTTGAGT CTTGGTGCTA TCAATCACCG TCTGTGTTTG 2520

AGCAAGGCAT TTGGCTGCTG TAAGCTTATT GCTTCATCTG TAAGCGGTGG TTTGTAATTC 2580

CTGATCTTCC CACCTCACAG TGATGTTGTG GGGATCCAGT GAGATAGAAT ACATGTAAGT 2640

GTGGTTTTGT AATTTGAAAA GTGCTATACT AAGGGAAAGA ATTGAGGAAT TAACTGCATA 2700

5 CGTTTTGGTG TTGCTTTTCA AATGTTTGAA AATAAAAAAA TGTTAAGAAA TGGGTTTCTT 2760

GCCTTAACCA GTCTCTCAAG TGATGAGACA GTGAAGTAAA ATTGAGTGCA CTAAACGAAT 2820

AAGATTCTGA GGAAGTCTTA TCTTCTGCAG TGAGTATGGC CCAATGCTTT CTGTGGCTAA 2880

ACAGATGTAA TGGGAAGAAA TAAAAGCCTA CGTGTTGGTA AATCCAACAG CAAGGGAGAT 2940

TTTTGAATCA TAATAACTCA TAAGGTGCTA TCTGTTCAGT GATGCCCTCA GAGCTCTTGC 3000

10 TGTTAGCTGG CAGCTGACGC TGCTAGGATA GTTAGTTTGG AAATGGTACT TCATAATAAA 3060

CTACACAAGG AAAGTCAGCC ACCGTGTCTT ATGAGGAATT GGACCTAATA AATTTTAGTG 3120

TGCCTTCCAA ACCTGAGAAT ATATGCTTTT GGAAGTTAAA ATTTAAATGG CTTTTGCCAC 3180

ATACATAGAT CTTCATGATG TGTGAGTGTA ATTCCATGTG GATATCAGTT ACCAAACATT 3240

ACAAAAAAAT TTTATGGCCC AAAATGACCA ACGAAATTGT TACAATAGAA TTTATCCAAT 3300

15 TTTGATCTTT TTATATTCTT CTACCACACC TGGAAACAGA CCAATAGACA TTTTGGGGTT 3360

TTATAATGGG AATTTGTATA AAGCATTACT CTTTTTCAAT AAATTGTTTT TTAATTTAAA 3420

AAAAGGAAAA AAAAAAAAAA AAA

20 Seq ID NO: 244 Protein sequence :

Protein Accession ft : AAD16433 .1

1 11 21 31 41 51 r M IANAGLQLLG F IILAFLGWIG A IIVSTALPQW R IIYSYAGDNI V ITAQAMYEGL W IMSCVSQSTG 60

QIQCKVFDSL LNLSSTLQAT RALMWGILL GVIAIFVATV GMKCMKCLED DEVQKMRMAV 120

IGGAIFLLAG LAILVATAWY GNRIVQEFYD PMTPVNARYE FGQALFTGWA AASLCLLGGA 180 LLCCSCPRKT TSYPTPRPYP KPAPSSGKDY V

30 Seq ID NO: 245 DNA sequence

Nucleic Acid Accession ft: CAT cluster

1 11 21 31 41 51

I I I I I I

35 _{ττττττττττ ττττττχτττ} TTTTCAAGG AGAGCACAAG GAACTTTATT AATGACTTTC 60

TTAATGGTTA AATGCTGTTT ACCAAGTGAC CCAGAGGCAG CGTGGTTTAG TGGTTTCAAC 120

AGCATGGTCC CGAGAGTCTG ACAAACCTCA GTTCAAATCC TTCTTTTGTC TTCACTTAGT 180

TTTTCTTCCT GAGATTTAGT TTCTTCATCG TTAACAATGA GGATATTAAT ATGTTTCACA 240

CAGTTGTTAT GAAGAATGCA TATATTAGAA TGCCTGTAGT CTCAGCTACT CAGGAGGCTA 300

40 AGGTGGGGAG GTCGCTCAAG CCCAGGAATT CAAAGCTGCA ATGCATTATG ATTACAGCTG 360

TTAATAGCCA CTGCACTTCA GCCTGGGCAA TGTAGTAAGA TCCCATCTCT GGCTCGGAGG 420 GTCCTACGCC CACGGAGTCT CGCTGATTGC TAGCACAGCA GTCTGAGATC AAACTGCA

Seq ID NO: 246 DNA sequence 45 Nucleic Acid Accession ft: XM_058553.2 Coding sequence: 897-1400

1 11 21 31 41 51 _ςπ I I I I I I

JO AATTTTCAGA AGTTTCGTAT GGGGATGGTT TTATATAAAT TCAGGTTTTT CCCACAATAA 60

TAAATGTATT TAGTCTCAGT GCTCAATAGA AGAGATTTCT AATAGAAAAG GATTCAAACT 120

GTGAAACCAT TTCTCTTTTA ATGTTTCACA TTCCTGTTAC AGATTTGTTC TCTTGTGACT 180

CTGTTATCCA TAATATGGAC AGTTCTTGAG TCCTAACATT GAGAGGTTTT CCCTTAGTGC 240

ATAGAGGGAA TGAGTATTAA TTGGAGAAGC TTAAAGTATT GCCACTTTAG CACTGAAGAT 300

55 TGGGATGAGA GGAGGTGAAA CCTCACTAGA AAAAGGGACA ATGTTAGTGT GGCCCTTCCT 360

GATCATGTTT AAGAAAAGTC ATGAAAATGG TGAACTAGTG TTTCCAAGCA TATTGGAAGG 420

GTTGAGTGTA TACTGTCTGT CAAAGACTTC CAGCATTTCC AGGTCCTAGA GAGGAACAAG 480

ACTGGTAACC TGCCTATCTG TATTTTTAAG AACCCAGGAG GAAAGCTTTA TAATAGAACA 540

TTATTTCTGT GTTTATGTAT AAGGGGTTTT TTGTTTTTTT AAAGACAGGA TCTCACTCCA 600

60 TTGTCCAGGC CAAGTGCAAT GGCACGAACC TCATAGCTCC TGGACTTAAG TGATCTGCCT 660

GCCTTTGCCT CCTGAGTAGC TGGGACTACA GGCATGAGCC CCCATGCCTG GCTAAGTTTG 720

TTTTTTTGTT TGTTTGTTTG TTTGTTTTTG GGGGGGGTTG TTTTGTTTTT TGTAGAGACG 780

TAGTCTTGCT TTGTTGCCAG GCTAGTCTCA AACTCCTGGC TTCAAGTGAT CCTCCTGCCT 840

CAGCCTCCCA GAGTGCTAGG ATTACAGCAC TTGGATTCAG CTTCTTCATT TCCAACATGG 900

65 AAGAAACTTA CACCGACTCC CTGGACCCTG AGAAGCTATT GCAATGCCCC TATGACAAAA 960

ACCATCAAAT CAGGGCTTGC AGGTTTCCTT ATCATCTTAT CAAGTGCAGA AAGAATCATC 1020

CTGATGTTGC AAGCAAATTG GCTACTTGTC CCTTCAATGC TCGCCACCAG GTTCCTCGAG 1080

CTGAAATTAG TCATCATATC TCAAGCTGTG ATGACAGAAG TTGTATTGAG CAAGATGTTG 1140

TCAACCAAAC CAGGAGCCTT AGACAAGAGA CTCTGGCTGA GAGCACTTGG CAGTGCCCTC 1200

70 CTTGCGATGA AGACTGGGAT AAAGATTTGT GGGAGCAGAC CAGCACCCCA TTTGTCTGGG 1260

GCACAACTCA CTACTCTGAC AACAACAGCC CTGCGAGCAA CATAGTTACA GAACATAAGA 1320

ATAACCTGGC TTCAGGCATG CGAGTTCCCA AATCTCTGCC GTATGTTCTG CCATGGAAAA 1380

ACAATGGAAA TGCACAGTAA CTGAATACCT ATCTCATCAA ATGCCAGACC CTAGAAGACT 1440

GTTGCTTCTT CTTCTACCAG TGGGTTCTCA TTTTCCTCCT AATCTAATTA TAGAATGGTA 1500

75 AACTCCCTGT GACTTTCCAA ACTGACAAGC ACACTTTTTT CCTCCCCCCT TGAATCCTCA 1560 TTTAATGCAA GAACCCTCAT ACTCAGAAGC TTCCAAATAA ACCTTTGATA CAGATTG

Seq ID NO: 247 Protein sequence:

80 Protein Accession #: XP 058553.1

1 11 21 31 41 51

I I I I I I

MEETYTDSLD PEKLLQCPYD KNHQIRACRF PYHLIKCRKN HPDVASKLAT CPFNARHQVP 60 85 RAEISHHISS CDDRSCIEQD WNQTRSLRQ ETLAESTWQC PPCDEDWDKD LWEQTSTPFV 120 WGTTHYSDNN SPASNIVTEH KNNLASGMRV PKSLPYVLPW KNNGNAQ Seq ID NO: 248 DNA sequence Nucleic Acid Accession ft: NM_003392 Coding sequence: 758..1855

1 11 21 31 41 51

T ITAAGGAAAT CICGGGCTGCT CITTCCCCATC TIGGAAGTGGC TITTCCCCACA TICGGCTCGTA 60

AACTGATTAT GAAACATACG ATGTTAATTC GGAGCTGCAT TTCCCAGCTG GGCACTCTCG 120

CGCGCTGGTC CCCGGGGCCT CGCCCCCCAC CCCCTGCCCT TCCCTCCCGC GTCCTGCCCC 180

CATCCTCCAC CCCCCGCGCT GGCCACCCCG CCTCCTTGGC AGCCTCTGGC GGCAGCGCGC 240

TCCACTCGCC TCCCGTGCTC CTCTCGCCCA TGGAATTAAT TCTGGCTCCA CTTGTTGCTC 300

GGCCCAGGTT GGGGAGAGGA CGGAGGGTGG CCGCAGCGGG TTCCTGAGTG AATTACCCAG 360

GAGGGACTGA GCACAGCACC AACTAGAGAG GGGTCAGGGG GTGCGGGACT CGAGCGAGCA 420

GGAAGGAGGC AGCGCCTGGC ACCAGGGCTT TGACTCAACA GAATTGAGAC ACGTTTGTAA 480

TCGCTGGCGT GCCCCGCGCA CAGGATCCCA GCGAAAATCA GATTTCCTGG TGAGGTTGCG 540

TGGGTGGATT AATTTGGAAA AAGAAACTGC CTATATCTTG CCATCAAAAA ACTCACGGAG 600

GAGAAGCGCA GTCAATCAAC AGTAAACTTA AGAGACCCCC GATGCTCCCC TGGTTTAACT 660

TGTATGCTTG AAAATTATCT GAGAGGGAAT AAACATCTTT TCCTTCTTCC CTCTCCAGAA 720

GTCCATTGGA ATATTAAGCC CAGGAGTTGC TTTGGGGATG GCTGGAAGTG CAATGTCTTC 780

CAAGTTCTTC CTAGTGGCTT TGGCCATATT TTTCTCCTTC GCCCAGGTTG TAATTGAAGC 840

CAATTCTTGG TGGTCGCTAG GTATGAATAA CCCTGTTCAG ATGTCAGAAG TATATATTAT 900

AGGAGCACAG CCTCTCTGCA GCCAACTGGC AGGACTTTCT CAAGGACAGA AGAAACTGTG 960

CCACTTGTAT CAGGACCACA TGCAGTACAT CGGAGAAGGC GCGAAGACAG GCATCAAAGA 1020

ATGCCAGTAT CAATTCCGAC ATCGACGGTG GAACTGCAGC ACTGTGGATA ACACCTCTGT 1080

TTTTGGCAGG GTGATGCAGA TAGGCAGCCG CGAGACGGCC TTCACATACG CCGTGAGCGC 1140

AGCAGGGGTG GTGAACGCCA TGAGCCGGGC GTGCCGCGAG GGCGAGCTGT CCACCTGCGG 1200

CTGCAGCCGC GCCGCGCGCC CCAAGGACCT GCCGCGGGAC TGGCTCTGGG GCGGCTGCGG 1260

CGACAACATC GACTATGGCT ACCGCTTTGC CAAGGAGTTC GTGGACGCCC GCGAGCGGGA 1320

GCGCATCCAC GCCAAGGGCT CCTACGAGAG TGCTCGCATC CTCATGAACC TGCACAACAA 1380

CGAGGCCGGC CGCAGGACGG TGTACAACCT GGCTGATGTG GCCTGCAAGT GCCATGGGGT 1440

GTCCGGCTCA TGTAGCCTGA AGACATGCTG GCTGCAGCTG GCAGACTTCC GCAAGGTGGG 1500

TGATGCCCTG AAGGAGAAGT ACGACAGCGC GGCGGCCATG CGGCTCAACA GCCGGGGCAA 1560

GTTGGTACAG GTCAACAGCC GCTTCAACTC GCCCACCACA CAAGACCTGG TCTACATCGA 1620

CCCCAGCCCT GACTACTGCG TGCGCAATGA GAGCACCGGC TCGCTGGGCA CGCAGGGCCG 1680

CCTGTGCAAC AAGACGTCGG AGGGCATGGA TGGCTGCGAG CTCATGTGCT GCGGCCGTGG 1740

GTACGACCAG TTCAAGACCG TGCAGACGGA GCGCTGCCAC TGCAAGTTCC ACTGGTGCTG 1800

CTACGTCAAG TGCAAGAAGT GCACGGAGAT CGTGGACCAG TTTGTGTGCA AGTAGTGGGT 1860

GCCACCCAGC ACTCAGCCCC GCTCCCAGGA CCCGCTTATT TATAGAAAGT ACAGTGATTC 1920

TGGTTTTTGG TTTTTAGAAA TATTTTTTAT TTTTCCCCAA GAATTGCAAC CGGAACCATT 1980

TTTTTTCCTG TTACCATCTA AGAACTCTGT GGTTTATTAT TAATATTATA ATTATTATTT 2040

GGCAATAATG GGGGTGGGAA CCACGAAAAA TATTTATTTT GTGGATCTTT GAAAAGGTAA 2100

TACAAGACTT CTTTTGGATA GTATAGAATG AAGGGGGAAA TAACACATAC CCTAACTTAG 2160

CTGTGTGGGA CATGGTACAC ATCCAGAAGG TAAAGAAATA CATTTTCTTT TTCTCAAATA 2220

TGCCATCATA TGGGATGGGT AGGTTCCAGT TGAAAGAGGG TGGTAGAAAT CTATTCACAA 2280

TTCAGCTTCT ATGACCAAAA TGAGTTGTAA ATTCTCTGGT GCAAGATAAA AGGTCTTGGG 2340

AAAACAAAAC AAAACAAAAC AAACCTCCCT TCCCCAGCAG GGCTGCTAGC TTGCTTTCTG 2400

CATTTTCAAA ATGATAATTT ACAATGGAAG GACAAGAATG TCATATTCTC AAGGAAAAAA 2460

GGTATATCAC ATGTCTCATT CTCCTCAAAT ATTCCATTTG CAGACAGACC GTCATATTCT 2520

AATAGCTCAT GAAATTTGGG CAGCAGGGAG GAAAGTCCCC AGAAATTAAA AAATTTAAAA 2580

CTCTTATGTC AAGATGTTGA TTTGAAGCTG TTATAAGAAT TGGGATTCCA GATTTGTAAA 2640

AAGACCCCCA ATGATTCTGG ACACTAGATT TTTTGTTTGG GGAGGTTGGC TTGAACATAA 2700

ATGAAATATC CTGTATTTTC TTAGGGATAC TTGGTTAGTA AATTATAATA GTAGAAATAA 2760

TACATGAATC CCATTCACAG GTTTCTCAGC CCAAGCAACA AGGTAATTGC GTGCCATTCA 2820

GCACTGCACC AGAGCAGACA ACCTATTTGA GGAAAAACAG TGAAATCCAC CTTCCTCTTC 2880

ACACTGAGCC CTCTCTGATT CCTCCGTGTT GTGATGTGAT GCTGGCCACG TTTCCAAACG 2940

GCAGCTCCAC TGGGTCCCCT TTGGTTGTAG GACAGGAAAT GAAACATTAG GAGCTCTGCT 3000

TGGAAAACAG TTCACTACTT AGGGATTTTT GTTTCCTAAA ACTTTTATTT TGAGGAGCAG 3060

TAGTTTTCTA TGTTTTAATG ACAGAACTTG GCTAATGGAA TTCACAGAGG TGTTGCAGCG 3120

TATCACTGTT ATGATCCTGT GTTTAGATTA TCCACTCATG CTTCTCCTAT TGTACTGCAG 3180

GTGTACCTTA AAACTGTTCC CAGTGTACTT GAACAGTTGC ATTTATAAGG GGGGAAATGT 3240

GGTTTAATGG TGCCTGATAT CTCAAAGTCT TTTGTACATA ACATATATAT ATATATACAT 3300

ATATATAAAT ATAAATATAA ATATATCTCA TTGCAGCCAG TGATTTAGAT TTACAGCTTA 3360

CTCTGGGGTT ATCTCTCTGT CTAGAGCATT GTTGTCCTTC ACTGCAGTCC AGTTGGGATT 3420

ATTCCAAAAG TTTTTTGAGT CTTGAGCTTG GGCTGTGGCC CCGCTGTGAT CATACCCTGA 3480

GCACGACGAA GCAACCTCGT TTCTGAGGAA GAAGCTTGAG TTCTGACTCA CTGAAATGCG 3540

TGTTGGGTTG AAGATATCTT TTTTTCTTTT CTGCCTCACC CCTTTGTCTC CAACCTCCAT 3600

TTCTGTTCAC TTTGTGGAGA GGGCATTACT TGTTCGTTAT AGACATGGAC GTTAAGAGAT 3660

ATTCAAAACT CAGAAGCATC AGCAATGTTT CTCTTTTCTT AGTTCATTCT GCAGAATGGA 3720

AACCCATGCC TATTAGAAAT GACAGTACTT ATTAATTGAG TCCCTAAGGA ATATTCAGCC 3780

CACTACATAG ATAGCTTTTT TTTTTTTTTT TTTTTTTTAA TAAGGACACC TCTTTCCAAA 3840

CAGGCCATCA AATATGTTCT TATCTCAGAC TTACGTTGTT TTAAAAGTTT GGAAAGATAC 3900

ACATCTTTTC ATACCCCCCC TTAGGAGGTT GGGCTTTCAT ATCACCTCAG CCAACTGTGG 3960

CTCTTAATTT ATTGCATAAT GATATCCACA TCAGCCAACT GTGGCTCTTT AATTTATTGC 4020

ATAATGATAT TCACATCCCC TCAGTTGCAG TGAATTGTGA GCAAAAGATC TTGAAAGCAA 4080

AAAGCACTAA TTAGTTTAAA ATGTCACTTT TTTGGTTTTT ATTATACAAA AACCATGAAG 4140

TACTTTTTTT ATTTGCTAAA TCAGATTGTT CCTTTTTAGT GACTCATGTT TATGAAGAGA 4200

GTTGAGTTTA ACAATCCTAG CTTTTAAAAG AAACTATTTA ATGTAAAATA TTCTACATGT 4260

CATTCAGATA TTATGTATAT CTTCTAGCCT TTATTCTGTA CTTTTAATGT ACATATTTCT 4320

GTCTTGCGTG ATTTGTATAT TTCACTGGTT TAAAAAACAA ACATCGAAAG G-CTTATTCCA 4380 AATGGAAGAT AGAATATAAA ATAAAACGTT ACTTGTAAAA AAAAAAAA

Seq ID NO: 249 Protein sequence: Protein Accession ft: NP_003383

1 11 21 31 41 51

I I I I I I MAGSAMSSKF FLVALAIFFS FAQWIEANS WWSLGMNNPV QMSEVYIIGA QPLCSQLAGL 60

SQGQKKLCHL YQDHMQYIGE GAKTGIKECQ YQFRHRRWNC STVDNTSVFG RVMQIGSRET 120

AFTYAVSAAG WNAMSRACR EGELSTCGCS RAARPKDLPR DWLWGGCGDN IDYGYRFAKE 180

FVDARERERI HAKGSYESAR ILMNLHNNEA GRRTVYNLAD VACKCHGVSG SCSLKTCWLQ 240 LADFRKVGDA LKEKYDSAAA MRLNSRGKLV QVNSRFNSPT TQDLVYIDPS PDYCVRNEST 300

GSLGTQGRLC NKTSEGMDGC ELMCCGRGYD QFKTVQTERC HCKFHWCCYV KCKKCTEIVD 360 QFVCK

Seq ID NO: 250 DNA sequence Nucleic Acid Accession ft: NM_014058 Coding sequence: 56..1324

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TGACTTGGAT GTAGACCTCG ACCTTCACAG GACTCTTCAT TGCTGGTTGG CAATGATGTA 60

TCGGCCAGAT GTGGTGAGGG CTAGGAAAAG AGTTTGTTGG GAACCCTGGG TTATCGGCCT 120

CGTCATCTTC ATATCCCTGA TTGTCCTGGC AGTGTGCATT GGACTCACTG TTCATTATGT 180

GAGATATAAT CAAAAGAAGA CCTACAATTA CTATAGCACA TTGTCATTTA CAACTGACAA 240

ACTATATGCT GAGTTTGGCA GAGAGGCTTC TAACAATTTT ACAGAAATGA GCCAGAGACT 300

TGAATCAATG GTGAAAAATG CATTTTATAA ATCTCCATTA AGGGAAGAAT TTGTCAAGTC 360

TCAGGTTATC AAGTTCAGTC AACAGAAGCA TGGAGTGTTG GCTCATATGC TGTTGATTTG 420

TAGATTTCAC TCTACTGAGG ATCCTGAAAC TGTAGATAAA ATTGTTCAAC TTGTTTTACA 480

TGAAAAGCTG CAAGATGCTG TAGGACCCCC TAAAGTAGAT CCTCACTCAG TTAAAATTAA 540

AAAAATCAAC AAGACAGAAA CAGACAGCTA TCTAAACCAT TGCTGCGGAA CACGAAGAAG 600

TAAAACTCTA GGTCAGAGTC TCAGGATCGT TGGTGGGACA GAAGTAGAAG AGGGTGAATG 660

GCCCTGGCAG GCTAGCCTGC AGTGGGATGG GAGTCATCGC TGTGGAGCAA CCTTAATTAA 720

TGCCACATGG CTTGTGAGTG CTGCTCACTG TTTTACAACA TATAAGAACC CTGCCAGATG 780

GACTGCTTCC TTTGGAGTAA CAATAAAACC TTCGAAAATG AAACGGGGTC TCCGGAGAAT 840

AATTGTCCAT GAAAAATACA AACACCCATC ACATGACTAT GATATTTCTC TTGCAGAGCT 900

TTCTAGCCCT GTTCCCTACA CAAATGCAGT ACATAGAGTT TGTCTCCCTG ATGCATCCTA 960

TGAGTTTCAA CCAGGTGATG TGATGTTTGT GACAGGATTT GGAGCACTGA AAAATGATGG 1020

TTACAGTCAA AATCATCTTC GACAAGCACA GGTGACTCTC ATAGACGCTA CAACTTGCAA 1080

TGAACCTCAA GCTTACAATG ACGCCATAAC TCCTAGAATG TTATGTGCTG GCTCCTTAGA 1140

AGGAAAAACA GATGCATGCC AGGGTGACTC TGGAGGACCA CTGGTTAGTT CAGATGCTAG 1200

AGATATCTGG TACCTTGCTG GAATAGTGAG CTGGGGAGAT GAATGTGCGA AACCCAACAA 1260

GCCTGGTGTT TATACTAGAG TTACGGCCTT GCGGGACTGG ATTACTTCAA AAACTGGTAT 1320

CTAAGAGAGA AAAGCCTCAT GGAACAGATA ACATTTTTTT TTGTTTTTTG GGTGTGGAGG 1380

CCATTTTTAG AGATACAGAA TTGGAGAAGA CTTGCAAAAC AGCTAGATTT GACTGATCTC 1440 AATAAACTGT TTGCTTGATG CAAAAAAAAA A

Seq ID NO: 251 Protein sequence: Protein Accession ft: NP_054777

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MYRPDWRAR KRVCWEPWVI GLVIFISLIV LAVCIGLTVH YVRYNQKKTY NYYSTLSFTT 60

DKLYAEFGRE ASNNFTEMSQ RLESMVKNAF YKSPLREEFV KSQVIKFSQQ KHGVLAHMLL 120

ICRFHSTEDP ETVDKIVQLV LHEKLQDAVG PPKVDPHSVK IKKINKTETD SYLNHCCGTR 180

RSKTLGQSLR IVGGTEVEEG EWPWQASLQW DGSHRCGATL INATWLVSAA HCFTTYKNPA 240

RWTASFGVTI KPSKMKRGLR RIIVHEKYKH PSHDYDISLA ELSSPVPYTN AVHRVCLPDA 300

SYEFQPGDVM FVTGFGALKN DGYSQNHLRQ AQVTLIDATT CNEPQAYNDA ITPRMLCAGS 360

LEGKTDACQG DSGGPLVSSD ARDIWYLAGI VSWGDECAKP NKPGVYTRVT ALRDWITSKT 420 GI

Seq ID NO: 252 DNA sequence

Nucleic Acid Accession ft: NM_003504.2

Coding sequence: 71-1771

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GGCACGAGGC CTCGTGCCGC CGGGCTCTTG GTACCTCAGC GCGAGCGCCA GGCGTCCGGC 60

CGCCGTGGCT ATGTTCGTGT CCGATTTCCG CAAAGAGTTC TACGAGGTGG TCCAGAGCCA 120

GAGGGTCCTT CTCTTCGTGG CCTCGGACGT GGATGCTCTG TGTGCGTGCA AGATCCTTCA 180

GGCCTTGTTC CAGTGTGACC ACGTGCAATA TACGCTGGTT CCAGTTTCTG GGTGGCAAGA 240

ACTTGAAACT GCATTTCTTG AGCATAAAGA ACAGTTTCAT TATTTTATTC TCATAAACTG 300

TGGAGCTAAT GTAGACCTAT TGGATATTCT TCAACCTGAT GAAGACACTA TATTCTTTGT 360

GTGTGACACC CATAGGCCAG TCAATGTCGT CAATGTATAC AACGATACCC AGATCAAATT 420

ACTCATTAAA CAAGATGATG ACCTTGAAGT TCCCGCCTAT GAAGACATCT TCAGGGATGA 480

AGAGGAGGAT GAAGAGCATT CAGGAAATGA CAGTGATGGG TCAGAGCCTT CTGAGAAGCG 540

CACACGGTTA GAAGAGGAGA TAGTGGAGCA AACCATGCGG AGGAGGCAGC GGCGAGAGTG 600

GGAGGCCCGG AGAAGAGACA TCCTCTTTGA CTACGAGCAG TATGAATATC ATGGGACATC 660

GTCAGCCATG GTGATGTTTG AGCTGGCTTG GATGCTGTCC AAGGACCTGA ATGACATGCT 720

GTGGTGGGCC ATCGTTGGAC TAACAGACCA GTGGGTGCAA GACAAGATCA CTCAAATGAA 780

ATACGTGACT GATGTTGGTG TCCTGCAGCG CCACGTTTCC CGCCACAACC ACCGGAACGA 840

GGATGAGGAG AACACACTCT CCGTGGACTG CACACGGATC TCCTTTGAGT ATGACCTCCG 900

CCTGGTGCTC TACCAGCACT GGTCCCTCCA TGACAGCCTG TGCAACACCA GCTATACCGC 960

AGCCAGGTTC AAGCTGTGGT CTGTGCATGG ACAGAAGCGG CTCCAGGAGT TCCTTGCAGA 1020

CATGGGTCTT CCCCTGAAGC AGGTGAAGCA GAAGTTCCAG GCCATGGACA TCTCCTTGAA 1080

GGAGAATTTG CGGGAAATGA TTGAAGAGTC TGCAAATAAA TTTGGGATGA AGGACATGCG 1140

CGTGCAGACT TTCAGCATTC ATTTTGGGTT CAAGCACAAG TTTCTGGCCA GCGACGTGGT 1200

CTTTGCCACC ATGTCTTTGA TGGAGAGCCC CGAGAAGGAT GGCTCAGGGA CAGATCACTT 1260

CATCCAGGCT CTGGACAGCC TCTCCAGGAG TAACCTGGAC AAGCTGTACC ATGGCCTGGA 1320

ACTCGCCAAG AAGCAGCTGC GAGCCACCCA GCAGACCATT GCCAGCTGCC TTTGCACCAA 1380

CCTCGTCATC TCCCAGGGGC CTTTCCTGTA CTGCTCTCTC ATGGAGGGCA CTCCAGATGT 1440

CATGCTGTTC TCTAGGCCGG CATCCCTAAG CCTGCTCAGC AAACACCTGC TCAAGTCCTT 1500

TGTGTGTTCG ACAAAGAACC GGCGCTGCAA ACTGCTGCCC CTGGTGATGβ CTGCCCCCCT 1560 GAGCATGGAG CATGGCACAG TGACCGTGGT GGGCATCCCC CCAGAGACCG ACAGCTCGGA 1620

CAGGAAGAAC TTTTTTGGGA GGGCGTTTGA GAAGGCAGCG GAAAGCACCA GCTCCCGGAT 1680

GCTGCACAAC CATTTTGACC TCTCAGTAAT TGAGCTGAAA GCTGAGGATC GGAGCAAGTT 1740

TCTGGACGCA CTTATTTCCC TCCTGTCCTA GGAATTTGAT TCTTCCAGAA TGACCTTCTT 1800 ATTTATGTAA CTGGCTTTCA TTTAGATTGT AAGTTATGGA CATGATTTGA GATGTAGAAG 1860

CCATTTTTTA TTAAATAAAA TGCTTATTTT AGGCTCCGTC CCCAAAAAAA AAAAAAAAAA 1920 AAAAAAAAAA AA

Seq ID NO: 253 Protein sequence: Protein Accession ft: NP_003495.1

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MFVSDFRKEF YEWQSQRVL LFVASDVDAL CACKILQALF QCDHVQYTLV PVSGWQELET 60 AFLEHKEQFH YFILINCGAN VDLLDILQPD EDTIFFVCDT HRPVNWNVY NDTQIKLLIK 120

QDDDLEVPAY EDIFRDEEED EEHSGNDSDG SEPSEKRTRL EEEIVEQTMR RRQRREWEAR 180

RRDILFDYEQ YEYHGTSSAM VMFELAWMLS KDLNDMLWWA IVGLTDQWVQ DKITQMKYVT 240

DVGVLQRHVS RHNHRNEDEE NTLSVDCTRI SFEYDLRLVL YQHWSLHDSL CNTSYTAARF 300

KLWSVHGQKR LQEFLADMGL PLKQVKQKFQ AMDISLKENL REMIEESANK FGMKDMRVQT 360 FSIHFGFKHK FLASDWFAT MSLMESPEKD GSGTDHFIQA LDSLSRSNLD KLYHGLELAK 420

KQLRATQQTI ASCLCTNLVI SQGPFLYCSL MEGTPDVMLF SRPASLSLLS KHLLKSFVCS 480

TKNRRCKLLP LVMAAPLSME HGTVTWGIP PETDSSDRKN FFGRAFEKAA ESTSSRMLHN 540

HFDLSVIELK AEDRSKFLDA LISLLS Seq ID NO: 254 DNA sequence

Nucleic Acid Accession ft: NM_022337 Coding sequence: 48..683

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GGCTGCGCTT CCCTGGTCAG GCACGGCACG TCTGGCCGGC CGCCAGGATG CAGGCCCCGC 60

ACAAGGAGCA CCTGTACAAG TTGCTGGTGA TTGGCGACCT GGGCGTGGGG AAGACCAGTA 120

TCATCAAGCG CTACGTGCAC CAGAACTTCT CCTCGCACTA CCGGGCCACA ATCGGCGTGG 180

ACTTCGCGCT CAAGGTGCTC CACTGGGACC CGGAGACTGT GGTGCGCCTG CAGCTCTGGG 240

ATATCGCAGG TCAAGAAAGA TTTGGAAACA TGACGAGGGT CTATTACCGA GAAGCTATGG 300

GTGCATTTAT TGTCTTCGAT GTCACCAGGC CAGCCACATT TGAAGCAGTG GCAAAGTGGA 360

AAAATGATTT GGACTCCAAG TTAAGTCTCC CTAATGGCAA ACCGGTTTCA GTGGTTTTGT 420

TGGCCAACAA ATGTGACCAG GGGAAGGATG TGCTCATGAA CAATGGCCTC AAGATGGACC 480

AGTTCTGCAA GGAGCACGGT TTCGTAGGAT GGTTTGAAAC ATCAGCAAAG GAAAATATAA 540

ACATTGATGA AGCCTCCAGA TGCCTGGTGA AACACATACT TGCAAATGAG TGTGACCTAA 600

TGGAGTCTAT TGAGCCGGAC GTCGTGAAGC CCCATCTCAC ATCAACCAAG GTTGCCAGCT 660

GCTCTGGCTG TGCCAAATCC TAGTAGGCAC CTTTGCTGGT GTCTGGTAGG AATGACCTCA 720

TTGTTCCACA AATTGTGCCT CTATTTTTAC CATTTTGGGT AAACGTCAGG ATAGATATAC 780

CACATGTGGC AAGCCAAAGA TCTATGCCTC TGTTTTTTCA ATGAGAGAGA AATAGCAAAT 840

GTTCTTTCTA TGCTTTCCTC ACCATCATCA CAGTGTTTAC AAACTTTTGA AAATATTTAG 900

TCTGTTACAA ACTTCTGTCA TGTAGCTGAC CAAAATCCTG CAGGGCCACA GTCGGCACTG 960

TTATTTGCTT CTTTTAATCA GCAAAGGCCT CAAGTCTTAA AATAAAAGGG GAGAAGAACA 1020

AACTAGCTGT CAAGTCAAGG ACTGGCTTTC ACCTTGCCCT GGTGTCTTTT TCCAGATTTC 1080

AATATATTCT CTGATGGCCT GACAGGCCTA TTAAGTAGAT GTGATATTTT CTTCCAAGAT 1140

GACCTCCATT CTCGGCAGAC CTAAGAGTTG CCTCTGAGTT AGCTCTTTGG AATCGTGAAC 1200

ACAGGTGTGC TATATTGTCC TTGTCCTAAC TGTCACTTGC CATGGCCTGA ATGTTGGCTT 1260

AACTGAATAT TGTATGAAAA GACATGCCTC CATATGTGCC TTTCTGTTAG CTCTCTTTGA 1320

CTCAAGCTGT GGGGCTCCTC TATACATGCT ATACATGTAA TATATATTAT ATATATTTTT 1380 GCAAGTGAAC AATAAAACAT TAAAAGATAA AA

Seq ID NO: 255 Protein sequence: Protein Accession ft: NP 071732

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MQAPHKEHLY KLLVIGDLGV GKTSIIKRYV HQNFSSHYRA TIGVDFALKV LHWDPETWR 60

LQLWDIAGQE RFGNMTRVYY REAMGAFIVF DVTRPATFEA VAKWKNDLDS KLSLPNGKPV 120

SWLLANKCD QGKDVLMNNG LKMDQFCKEH GFVGWFETSA KENINIDEAS RCLVKHILAN 180 ECDLMESIEP DWKPHLTST KVASCSGCAK S

Seq ID NO: 256 DNA sequence Nucleic Acid Accession ft: NM_016321 Coding sequence: 25..1464

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GGAACCGCCC GCTGCCAGCC CGGCCAGGCA CCCCTGCAGC ATGGCCTGGA ACACCAACCT 60

CCGCTGGCGG CTGCCGCTCA CCTGCCTGCT CCTGCAGGTG ATTATGGTGA TTCTCTTCGG 120

GGTGTTCGTG CGCTACGACT TCGAGGCCGA CGCCCACTGG TGGTCAGAGA GGACGCACAA 180

GAACTTGAGC GACATGGAGA ACGAATTCTA CTATCGCTAC CCAAGCTTCC AGGACGTGCA 240

CGTGATGGTC TTCGTGGGCT TGGGCTTCCT CATGACTTTC CTGCAGCGCT ACGGCTTCAG 300

CGCCGTGGGC TTCAACTTCC TGTTGGCAGC CTTCGGCATC CAGTGGGCGC TGCTCATGCA 360

GGGCTGGTTC CACTTCTTAC AAGACCGCTA CATCGTCGTG GGCGTGGAGA ACCTCATCAA 420

CGCTGACTTC TGCGTGGCCT CTGTCTGCGT GGCCTTTGGG GCAGTTCTGG GTAAAGTCAG 480

CCCCATTCAG CTGCTCATCA TGACTTTCTT CCAAGTGACC CTCTTCGCTG TGAATGAGTT 540

CATTCTCCTT AACCTGCTAA AGGTGAAGGA TGCAGGAGGC TCCATGACCA TCCACACATT 600

TGGCGCCTAC TTTGGGCTCA CAGTGACCCG GATCCTCTAC CGACGCAACC TAGAGCAGAG 660 CAAGGAGAGA CAGAATTCTG TGTACCAGTC GGACCTCTTT GCCATGATTG GCACCCTCTT 720

CCTGTGGATG TACTGGCCCA GCTTCAACTC AGCCATATCC TACCATGGGG ACAGCCAGCA 780

CCGAGCCGCC ATCAACACCT ACTGCTCCTT GGCAGCCTGC GTGCTTACCT CGGTGGCAAT 840 ATCCAGTGCC CTGCACAAGA AGGGCAAGCT GGACATGGTG CACATCCAGA ATGCCACGCT 900

CGCAGGAGGG GTGGCCGTGG GTACCGCTGC TGAGATGATG CTCATGCCTT ACGGTGCCCT 960

CATCATCGGC TTCGTCTGCG GCATCATCTC CACCCTGGGT TTTGTATACC TGACCCCATT 1020

CCTGGAGTCC CGGCTGCACA TCCAGGACAC ATGTGGCATT AACAATCTGC ATGGCATTCC 1080

TGGCATCATA GGCGGCATCG TGGGTGCTGT GACAGCGGCC TCCGCCAGCC TTGAAGTCTA 1140

TGGAAAAGAA GGGCTTGTCC ATTCCTTTGA CTTTCAAGGT TTCAACGGGG ACTGGACCGC 1200

AAGAACACAG GGAAAGTTCC AGATTTATGG TCTCTTGGTG ACCCTGGCCA TGGCCCTGAT 1260

GGGTGGCATC ATTGTGGGGC TCATTTTGAG ATTACCATTC TGGGGACAAC CTTCAGATGA 1320

GAACTGCTTT GAGGATGCGG TCTACTGGGA GATGCCTGAA GGGAACAGCA CTGTCTACAT 1380

CCCTGAGGAC CCCACCTTCA AGCCCTCAGG ACCCTCAGTA CCCTCAGTAC CCATGGTGTC 1440

CCCACTACCC ATGGCTTCCT CGGTACCCTT GGTACCCTAG GCTCCCAGGG CAGGTGAGGA 1500

GCAGGCTCCA CAGACTSTCC TGGGGCCCAG AGGAGCTGGT GCTGACCTAG CTAGGGATGC 1560

AAGAGTGAGC AAGCAGCACC CCCACCTGCT GGCTTGGCCT CAAGGTGCCT CCACCCCTGC 1620

CCTCCCCTTC ATCCCAGGGG GTCTGMCTGA GAATGGAGAA GGAGAAGCTA CAAAGTGGGC 1680

ATCCAAGCCG GGTTCTGGCT GCAGAAGTTC TGCCTCTGCC TGGGGTCTTG GCCACATTGG 1740

AGAAAAACAG GCTCAAAGTG GGGCTGGGAC CTGGTGGGTG AACCTGAGCT CTCCCAGGAG 1800

ACAACTTAGC TGCCAGTCAC CACCTATGAG GCTCTTCTAC CCCGTGCCTG CACCTCGGCC 1860

AGCATCTCCT ATGCTCCCTG GGTCCCCCAG ACCTCTCTGT GTTGTGTGCG TGGCAGCCTC 1920 CAGGAATAAA CATTCTTGTT GTCCTTTGTA AAAAAAAAAA AAAAAAAA

Seq ID NO: 257 Protein sequence: Protein Accession ft: NP 057405

11 21 31 41 51

MAWNTNLRWR L IPLTCLLLQV I IMVILFGVFV R IYDFEADAHW WSERTHKNLS DMENEFYYRY 60 PSFQDVHVMV FVGFGFLMTF LQRYGFSAVG FNFLLAAFGI QWALLMQGWF HFLQDRYIW 120 GVENLINADF CVASVCVAFG AVLGKVSPIQ LLIMTFFQVT LFAVNEFILL NLLKVKDAGG 180 SMTIHTFGAY FGLTVTRILY RRNLEQSKER QNSVYQSDLF AMIGTLFLWM YWPSFNSAIS 240 YHGDSQHRAA INTYCSLAAC VLTSVAISSA LHKKGKLDMV HIQNATLAGG VAVGTAAEMM 300 LMPYGALIIG FVCGIISTLG FVYLTPFLES RLHIQDTCGI NNLHGIPGII GGIVGAVTAA 360 SASLEVYGKE GLVHSFDFQG FNGDWTARTQ GKFQIYGLLV TLAMALMGGI IVGLILRLPF 420 WGQPSDENCF EDAVYWEMPE GNSTVYIPED PTFKPSGPSV PSVPMVSPLP MASSVPLVP

Seq ID NO: 258 DNA sequence

Nucleic Acid Accession ft: NM_002358.2

Coding sequence: 75..692

11 21 31 41 51

GGGAAGTGCT GTTGGAGCCG CTGTGGTTGC TGTCCGCGGA GTGGAAGCGC GTGCTTTTGT 60 TTGTGTCCCT GGCCATGGCG CTGCAGCTGT CCCGGGAGCA GGGAATCACC CTGCGCGGGA 120 GCGCCGAAAT CGTGGCCGAG TTCTTCTCAT TCGGCATCAA CAGCATTTTA TATCAGCGTG 180 GCATATATCC ATCTGAAACC TTTACTCGAG TGCAGAAATA CGGACTCACC TTGCTTGTAA 240 CTACTGATCT TGAGCTCATA AAATACCTAA ATAATGTGGT GGAACAACTG AAAGATTGGT 300 TATACAAGTG TTCAGTTCAG AAACTGGTTG TAGTTATCTC AAATATTGAA AGTGGTGAGG 360 TCCTGGAAAG ATGGCAGTTT GATATTGAGT GTGACAAGAC TGCAAAAGAT GACAGTGCAC 420 CCAGAGAAAA GTCTCAGAAA GCTATCCAGG. ATGAAATCCG TTCAGTGATC AGACAGATCA 480 CAGCTACGGT GACATTTCTG CCACTGTTGG AAGTTTCTTG TTCATTTGAT CTGCTGATTT 540 ATACAGACAA AGATTTGGTT GTACCTGAAA AATGGGAAGA GTCGGGACCA CAGTTTATTA 600 CCAATTCTGA GGAAGTCCGC CTTCGTTCAT TTACTACTAC AATCCACAAA GTAAATAGCA 660 TGGTGGCCTA CAAAATTCCT GTCAATGACT GAGGATGACA TGAGGAAAAT AATGTAATTG 720 TAATTTTGAA ATGTGGTTTT CCTGAAATCA GGTCATCTAT AGTTGATATG TTTTATTTCA 780 TTGGTTAATT TTTACATGGA GAAAACCAAA ATGATACTTA CTGAACTGTG TGTAATTGTT ' 840 CCTTTATTTT TTTGGTACCT ATTTGACTTA CCATGGAGTT AACATCATGA ATTTATTGCA 900 CATTGTTCAA AAGGAACCAG GAGGTTTTTT TGTCAACATT GTGATGTATA TTCCTTTGAA 960 GATAGTAACT GTAGATGGAA AAACTTGTGC TATAAAGCTA GATGCTTTCC TAAATCAGAT 1020 GTTTTGGTCA AGTAGTTTGA CTCAGTATAG GTAGGGAGAT ATTTAAGTAT AAAATACAAC 1080 AAAGGAAGTC TAAATATTCA GAATCTTTGT TAAGGTCCTG AAAGTAACTC ATAATCTATA 1140 AACAATGAAA TATTGCTGTA TAGCTCCTTT TGACCTTCAT TTCATGTATA GTTTTCCCTA 1200 TTGAATCAGT TTCCAATTAT TTGACTTTAA TTTATGTAAC TTGAACCTAT GAAGCAATGG 1260 ATATTTGTAC TGTTTAATGT TCTGTGATAC AGAACTCTTA AAAATGTTTT TTCATGTGTT 1320 TTATAAAATC AAGTTTTAAG TGAAAGTGAG GAAATAAAGT TAAGTTTGTT TTAAAAAAAA 1380 AAAAAAAAAA

Seq ID NO: 259 Protein sequence: Protein Accession ft: NP 002349.1

11 21 31 41 51

MALQLSREQG ITLRGSAEIV AEFFSFGINS ILYQRGIYPS ETFTRVQKYG LTLLVTTDLE 60

LIKYLNNWE QLKDWLYKCS VQKLVWISN IESGEVLERW QFDIECDKTA KDDSAPREKS 120 QKAIQDEIRS VIRQITATVT FLPLLEVSCS FDLLIYTDKD LWPEKWEES GPQFITNSEE 180 VRLRSFTTTI HKVNSMVAYK IPVND

Seq ID NO: 260 DNA sequence Nucleic Acid Accession ft: NM_001211 Coding sequence: 43..3195

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AAAGGCCTGC AGCAGGACGA GGACCTGAGC CAGGAATGCA GGATGGCGGC GGTGAAGAAG 60 GAAGGGGGTG CTCTGAGTGA AGCCATGTCC CTGGAGGGAG ATGAATGGGA ACTGAGTAAA 120

GAAAATGTAC AACCTTTAAG GCAAGGGCGG ATCATGTCCA CGCTTCAGGG AGCACTGGCA 180

CAAGAATCTG CCTGTAACAA TACTCTTCAG CAGCAGAAAC GGGCATTTGA ATATGAAATT 240 CGATTTTACA CTGGAAATGA CCCTCTGGAT GTTTGGGATA GGTATATCAG CTGGACAGAG 300

CAGAACTATC CTCAAGGTGG GAAAGAGAGT AATATGTCAA CGTTATTAGA AAGAGCTGTA 360

GAAGCACTAC AAGGAGAAAA ACGATATTAT AGTGATCCTC GATTTCTCAA TCTCTGGCTT 420

AAATTAGGGC GTTTATGCAA TGAGCCTTTG GATATGTACA GTTACTTGCA CAACCAAGGG 480

ATTGGTGTTT GACTTGCTCA GTTCTATATC TCATGGGCAG AAGAATATGA AGCTAGAGAA 540

AACTTTAGGA AAGCAGATGC GATATTTCAG GAAGGGATTC AACAGAAGGC TGAACCACTA 600

GAAAGACTAC AGTCCCAGCA CCGACAATTC CAAGCTCGAG TGTCTCGGCA AACTCTGTTG 660

GCACTTGAGA AAGAAGAAGA GGAGGAAGTT TTTGAGTCTT CTGTACCACA ACGAAGCACA 720

CTAGCTGAAC TAAAGAGCAA AGGGAAAAAG ACAGCAAGAG CTCCAATCAT CCGTGTAGGA 780

GGTGCTCTCA AGGCTCCAAG CCAGAACAGA GGACTCCAAA ATCCATTTCC TCAACAGATG 840

CAAAATAATA GTAGAATTAC TGTTTTTGAT GAAAATGCTG ATGAGGCTTC TACAGCAGAG 900

TTGTCTAAGC CTACAGTCCA GCCATGGATA GCACCCCCCA TGCCCAGGGC CAAAGAGAAT 960

GAGCTGCAAG CAGGCCCTTG GAACACAGGC AGGTCCTTGG AACACAGGCC TCGTGGCAAT 1020

ACAGCTTCAC TGATAGCTGT ACCCGCTGTG CTTCCCAGTT TCACTCCATA TGTGGAAGAG 1080

ACTGCACAAC AGCCAGTTAT GACACCATGT AAAATTGAAC CTAGTATAAA CCACATCCTA 1140

AGCACCAGAA AGCCTGGAAA GGAAGAAGGA GATCCTCTAC AAAGGGTTCA GAGCCATCAG 1200

CAAGCGTCTG AGGAGAAGAA AGAGAAGATG ATGTATTGTA AGGAGAAGAT TTATGCAGGA 1260

GTAGGGGAAT TCTCCTTTGA AGAAATTCGG GCTGAAGTTT TCCGGAAGAA ATTAAAAGAG 1320

CAAAGGGAAG CCGAGCTATT GACCAGTGCA GAGAAGAGAG CAGAAATGCA GAAACAGATT 1380

GAAGAGATGG AGAAGAAGCT AAAAGAAATC CAAACTACTC AGCAAGAAAG AACAGGTGAT 1440

CAGCAAGAAG AGACGATGCC TACAAAGGAG ACAACTAAAC TGCAAATTGC TTCCGAGTCT 1500

CAGAAAATAC CAGGAATGAC TCTATCCAGT TCTGTTTGTC AAGTAAACTG TTGTGCCAGA 1560

GAAACTTCAC TTGCGGAGAA CATTTGGCAG GAACAACCTC ATTCTAAAGG TCCCAGTGTA 1620

CCTTTCTCCA TTTTTGATGA GTTTCTTCTT TCAGAAAAGA AGAATAAAAG TCCTCCTGCA 1680

GATCCCCCAC GAGTTTTAGC TCAACGAAGA CCCCTTGCAG TTCTCAAAAC CTCAGAAAGC 1740

ATCACCTCAA ATGAAGATGT GTCTCCAGAT GTTTGTGATG AATTTACAGG AATTGAACCC 1800

TTGAGCGAGG ATGCCATTAT CACAGGCTTC AGAAATGTAA CAATTTGTCC TAACCCAGAA 1860

GACACTTGTG ACTTTGCCAG AGCAGCTCGT TTTGTATCCA CTCCTTTTCA TGAGATAATG 1920

TCCTTGAAGG ATCTCCCTTC TGATCCTGAG AGACTGTTAC CGGAAGAAGA TCTAGATGTA 1980

AAGACCTCTG AGGACCAGCA GACAGCTTGT GGCACTATCT ACAGTCAGAC TCTCAGCATC 2040

AAGAAGCTGA GCCCAATTAT TGAAGACAGT CGTGAAGCCA CACACTCCTC TGGCTTCTCT 2100

GGTTCTTCTG CCTCGGTTGC AAGCACCTCC TCCATCAAAT GTCTTCAAAT TCCTGAGAAA 2160

CTAGAACTTA CTAATGAGAC TTCAGAAAAC CCTACTCAGT CACCATGGTG TTCACAGTAT 2220

CGCAGACAGC TACTGAAGTC CCTACCAGAG TTAAGTGCCT CTGCAGAGTT GTGTATAGAA 2280

GACAGACCAA TGCCTAAGTT GGAAATTGAG AAGGAAATTG AATTAGGTAA TGAGGATTAC 2340

TGCATTAAAC GAGAATACCT AATATGTGAA GATTACAAGT TATTCTGGGT GGCGCCAAGA 2400

AACTCTGCAG AATTAACAGT AATAAAGGTA TCTTCTCAAC CTGTCCCATG GGACTTTTAT 2460

ATCAACCTCA AGTTAAAGGA ACGTTTAAAT GAAGATTTTG ATCATTTTTG CAGCTGTTAT 2520

CAATATCAAG ATGGCTGTAT TGTTTGGCAC CAATATATAA ACTGCTTCAC CCTTCAGGAT 2580

CTTCTCCAAC ACAGTGAATA TATTACCCAT GAAATAACAG TGTTGATTAT TTATAACCTT 2640

TTGACAATAG TGGAGATGCT ACACAAAGCA GAAATAGTCC ATGGTGACTT GAGTCCAAGG 2700

TGTCTGATTC TCAGAAACAG AATCCACGAT CCCTATGATT GTAACAAGAA CAATCAAGCT 2760

TTGAAGATAG TGGACTTTTC CTACAGTGTT GACCTTAGGG TGCAGCTGGA TGTTTTTACC 2820

CTCAGCGGCT TTCGGACTGT ACAGATCCTG GAAGGACAAA AGATCCTGGC TAACTGTTCT 2880

TCTCCCTACC AGGTAGACCT GTTTGGTATA GCAGATTTAG CACATTTACT ATTGTTCAAG 2940

GAACACCTAC AGGTCTTCTG GGATGGGTCC TTCTGGAAAC TTAGCCAAAA TATTTCTGAG 3000

CTAAAAGATG GTGAATTGTG GAATAAATTC TTTGTGCGGA TTCTGAATGC CAATGATGAG 3060

GCCACAGTGT CTGTTCTTGG GGAGCTTGCA GCAGAAATGA ATGGGGTTTT TGACACTACA 3120

TTCCAAAGTC ACCTGAACAA AGCCTTATGG AAGGTAGGGA AGTTAACTAG TCCTGGGGCT 3180

TTGCTCTTTC AGTGAGCTAG GCAATCAAGT CTCACAGATT GCTGCCTCAG AGCAATGGTT 3240

GTATTGTGGA ACACTGAAAC TGTATGTGCT GTAATTTAAT TTAGGACACA TTTAGATGCA 3300

CTACCATTGC TGTTCTACTT TTTGGTACAG GTATATTTTG ACGTCACTGA TATTTTTTAT 3360

ACAGTGATAT ACTTACTCAT GGCCTTGTCT AACTTTTGTG AAGAACTATT TTATTCTAAA 3420

CAGACTCATT ACAAATGGTT ACCTTGTTAT TTAACCCATT TGTCTCTACT TTTCCCTGTA 3480

CTTTTCCCAT TTGTAATTTG TAAAATGTTC TCTTATGATC ACCATGTATT TTGTAAATAA 3540 TAAAATAGTA TCTGTTAAAA AAAAAAAAAA AAAAAAAAAA AAA

Seq ID NQ: 261 Protein sequence: Protein Accession ft: NP_001202

1 11 21 31 41 51

M IAAVKKEGGA LISEAMSLEGD EIWELSKENVQ PILRQGRIMST LIQGALAQESA CINNTLQQQKR 60

AFEYEIRFYT GNDPLDVWDR YISWTEQNYP QGGKESNMST LLERAVEALQ GEKRYYSDPR 120

FLNLWLKLGR LCNEPLDMYS YLHNQGIGVS LAQFYISWAE EYEARENFRK ADAIFQEGIQ 180

QKAEPLERLQ SQHRQFQARV SRQTLLALEK EEEEEVFESS VPQRSTLAEL KSKGKKTARA 240

PIIRVGGALK APSQNRGLQN PFPQQMQNNS RITVFDENAD EASTAELSKP TVQPWIAPPM 300

PRAKENELQA GPWNTGRSLE HRPRGNTASL IAVPAVLPSF TPYVEETAQQ PVMTPCKIEP 360

SINHILSTRK PGKEEGDPLQ RVQSHQQASE EKKEKMMYCK EKIYAGVGEF SFEEIRAEVF 420

RKKLKEQREA ELLTSAEKRA EMQKQIEEME KKLKEIQTTQ QERTGDQQEE TMPTKETTKL 480

QIASESQKIP GMTLSSSVCQ VNCCARETSL AENIWQEQPH SKGPSVPFSI FDEFLLSEKK 540

NKSPPADPPR VLAQRRPLAV LKTSESITSN EDVSPDVCDE FTGIEPLSED AIITGPRNVT 600

ICPNPEDTCD FARAARFVST PFHEIMSLKD LPSDPERLLP EEDLDVKTSE DQQTACGTIY 660

SQTLSIKKLS PIIEDSREAT HSSGFSGSSA SVASTSSIKC LQIPEKLELT NETSENPTQS 720

PWCSQYRRQL LKSLPELSAS AELCIEDRPM PKLEIEKEIE LGNEDYCIKR EYLICEDYKL 780

FWVAPRNSAE LTVIKVSSQP VPWDFYINLK LKERLNEDFD HFCSCYQYQD GCIVWHQYIN 840

CFTLQDLLQH SEYITHEITV LIIYNLLTIV EMLHKAEIVH GDLSPRCLIL RNRIHDPYDC 900

NKNNQALKIV DFSYSVDLRV QLDVFTLSGF RTVQILEGQK ILANCSSPYQ VDLFGIADLA 960

HLLLFKEHLQ VFWDGSFWKL SQNISELKDG ELWNKFFVRI LNANDEATVS VLGELAAEMN 1020 GVFDTTFQSH LNKALWKVGK LTSPGALLFQ

Seq ID NO: 262 DNA sequence Nucleic Acid Accession ft: NM_003784 Coding sequence: 365..1507

1 11 21 31 41 51 GTCTACTTAT CAATAAGCAG CTGCCTGTGC AGAGTGCAGG CTGCACCTTT GGACAGCCTT 60

TAAAACTGAA TTCTCAGAAT TTTAGAACAA ATTTTTGTCT AGAAATGCTβ ACTTTGGTTC 120

ATTAGGTAGT GGTAAAACAG GCTCCCTTCG AAGCTCTCCT TCATCACCTT CCTAAGTGCA 180

TGTACAGGGA AGCTCTCCTT CATCACCTTC CTAAGTGCAT GGGGGAAAAT ACCTAGGGCT 240

CAACAGTCTT GAGAAGTGTG GAAACATTTT CTTTGTGAGT GAGAACAGAT CACCTAGAGA 300

AAGGAAACCA GATTCCCATC ACTGCTTCTG GGTATCAGAT GCTAGCGCTG CACTCCATTT 360

TGCAATGGCC TCCCTTGCTG CAGCAAATGC AGAGTTTTGC TTCAACCTGT TCAGAGAGAT 420

GGATGACAAT CAAGGAAATG GAAATGTGTT CTTTTCCTCT CTGAGCCTCT TCGCTGCCCT 480

GGCCCTGGTC CGCTTGGGCG CTCAAGATGA CTCCCTCTCT CAGATTGATA AGTTGCTTCA 540

TGTTAACACT GCCTCAGGAT ATGGAAACTC TTCTAATAGT CAGTCAGGGC TCCAGTCTCA 600

ACTGAAAAGA GTTTTTTCTG ATATAAATGC ATCCCACAAG GATTATGATC TCAGCATTGT 660

GAATGGGCTT TTTGCTGAAA AAGTGTATGG CTTTCATAAG GACTACATTG AGTGTGCCGA 720

AAAATTATAC GATGCCAAAG TGGAGCGAGT TGACTTTACG AATCATTTAG AAGACACTAG 780

ACGTAATATT AATAAGTGGG TTGAAAATGA AACACATGGC AAAATCAAGA ACGTGATTGG 840

TGAAGGTGGC ATAAGCTCAT CTGCTGTAAT GGTGCTGGTG AATGCTGTGT ACTTCAAAGG 900

CAAGTGGCAA TCAGCCTTCA CCAAGAGCGA AACCATAAAT TGCCATTTCA AATCTCCCAA 960

GTGCTCTGGG AAGGCAGTCG CCATGATGCA TCAGGAACGG AAGTTCAATT TGTCTGTTAT 1020

TGAGGACCCA TCAATGAAGA TTCTTGAGCT CAGATACAAT GGTGGCATAA ACATGTACGT 1080

TCTGCTGCCT GAGAATGACC TCTCTGAAAT TGAAAACAAA CTGACCTTTC AGAATCTAAT 1140

GGAATGGACC AATCCAAGGC GAATGACCTC TAAGTATGTT GAGGTATTTT TTCCTCAGTT 1200

CAAGATAGAG AAGAATTATG AAATGAAACA ATATTTGAGA GCCCTAGGGC TGAAAGATAT 1260

CTTTGATGAA TCCAAAGCAG ATCTCTCTGG GATTGCTTCG GGGGGTCGTC TGTATATATC 1320

AAGGATGATG CACAAATCTT ACATAGAGGT CACTGAGGAG GGCACCGAGG CTACTGCTGC 1380

CACAGGAAGT AATATTGTAG AAAAGCAACT CCCTCAGTCC ACGCTGTTTA GAGCTGACCA 1440

CCCATTCCTA TTTGTTATCA GGAAGGATGA CATCATCTTA TTCAGTGGCA AAGTTTCTTG 1500

CCCTTGAAAA TCCAATTGGT TTCTGTTATA GCAGTCCCCA CAACATCAAA GRACCACCAC 1560

AAGTCAATAG ATYTGRGTTT AATTGGAAAA ATGTGGTGTT TCCTTTGAGT TTATTTCTTC 1620

CTAACATTGG TCAGCAGATG ACACTGGTGA CTTGACCCTT CCTAGACACC TGGTTGATTG 1680

TCCTGATCCC TGCTCTTAGC ATTCTACCAC CATGTGTCTC ACCCATTTCT AATTTCATTG 1740

TCTTTCTTCC CACGCTCATT TCTATCATTC TCCCCCATGA CCCGTCTGGA AATTATGGAG 1800

RGTGCTCAAC TGGTAAGGAG AACGTAGAAG TAGCCCTAGG GATCCTTTTT GAAACTCTAC 1860

AGTTATCGCA GATATTCTAG CTTCATTGTA AGCAATCTAG GAAATAAGCC CTGCTGCTTT 1920

CTAGAAATAA GTGTGAAGGA TAAATTTTCT TTGTTGACCT ATGAAGATTT TAGAGTTTAC 1980

CTTCATATGT TTGATTTTAA ATCAGTGTAT AATCTAGATG GTAAAAAATG TGAAATTGGG 2040

ATTAGGGACC TACCAAAATA TTTCATTAAT GCTTTCAATT GACAAATTTT GGCCTTTCTT 2100

TGATAAGACA ATATGTACAT GTTTTTTCAA ATATTAAAGA TCTTTTAACT GTTGGCAGTT 2160

GTTATCTACA GAATCATATT TCATATGCTG TGTAGTTTAT AAGTTTTTCC TCTATTTATC 2220 AGAATAAAGA AATACAACAT ACCTGTAAA

Seq ID NO: 263 Protein sequence: Protein Accession ft: NP 003775

31

MASLAAANAE FCFNLFREMD DNQGNGNVFF SSLSLFAALA LVRLGAQDDS LSQIDKLLHV 60

NTASGYGNSS NSQSGLQSQL KRVFSDINAS HKDYDLSIVN GLFAEKVYGF HKDYIECAEK 120

LYDAKVERVD FTNHLEDTRR NINKWVENET HGKIKNVIGE GGISSSAVMV LVNAVYFKGK 180

WQSAFTKSET INCHFKSPKC SGKAVAMMHQ ERKFNLSVIE DPSMKILELR YNGGINMYVL 240

LPENDLSEIE NKLTFQNLME WTNPRRMTSK YVEVFFPQFK IEKNYEMKQY LRALGLKDIF 300

DESKADLSGI ASGGRLYISR MMHKSYIEVT EEGTEATAAT GSNIVEKQLP QSTLFRADHP 360

FLFVIRKDDI ILFSGKVSCP

Seq ID NO: 264 DNA sequence Nucleic Acid Accession ft: AB052906 Coding sequence: 74-814

11 21 31

AAAACCTTGA GGTGATTCAT CTTCCAGGCT CTCCTTCCAT CAAGTCTCTC CTCCCTAGCG 60

CTCTGGGTCC TTAATGGCAG CAGCCGCCGC TACCAAGATC CTTCTGTGCC TCCCGCTTCT 120

GCTCCTGCTG TCCGGCTGGT CCCGGGCTGG GCGAGCCGAC CCTCACTCTC TTTGCTATGA 180

CATCACCGTC ATCCCTAAGT TCAGACCTGG ACCACGGTGG TGTGCGGTTC AAGGCCAGGT 240

GGATGAAAAG ACTTTTCTTC ACTATGACTG TGGCAACAAG ACAGTCACAC CTGTCAGTCC 300

CCTGGGGAAG AAACTAAATG TCACAACGGC CTGGAAAGCA CAGAACCCAG TACTGAGAGA 360

GGTGGTGGAC ATACTTACAG AGCAACTGCG TGACATTCAG CTGGAGAATT ACACACCCAA 420

GGAACCCCTC ACCCTGCAGG CCAGGATGTC TTGTGAGCAG AAAGCTGAAG GACACAGCAG 480

TGGATCTTGG CAGTTCAGTT TCGATGGGCA GATCTTCCTC CTCTTTGACT CAGAGAAGAG 540

AATGTGGACA ACGGTTCATC CTGGAGCCAG AAAGATGAAA GAAAAGTGGG AGAATGACAA 600

GGTTGTGGCC ATGTCCTTCC ATTACTTCTC AATGGGAGAC TGTATAGGAT GGCTTGAGGA 660

CTTCTTGATG GGCATGGACA GCACCCTGGA GCCAAGTGCA GGAGCACCAC TCGCCATGTC 720

CTCAGGCACA ACCCAACTCA GGGCCACAGC CACCACCCTC ATCCTTTGCT GCCTCCTCAT 780

CATCCTCCCC TGCTTCATCC TCCCTGGCAT CTGAGGAGAG TCCTTTAGAG TGACAGGTTA 840

AAGCTGATAC CAAAAGGCTC CTGTGAGCAC GGTCTTGATC AAACTCGCCC TTCTGTCTGG 900

CCAGCTGCCC ACGACCTACG GTGTATGTCC AGTGGCCTCC AGCAGATCAT GATGACATCA 960

TGGACCCAAT AGCTCATTCA CTGCCTTGAT TCCTTTTGCC AACAATTTTA CCAGCAGTTA 1020

TACCTAACAT ATTATGCAAT TTTCTCTTGG TGCTACCTGA TGGAATTCCT GCACTTAAAG 1080

TTCTGGCTGA CTAAACAAGA TATATCATTT TCTTTCTTCT CTTTTTGTTT GGAAAATCAA 1140

GTACTTCTTT GAATGATGAT CTCTTTCTTG CAAATGATAT TGTCAGTAAA ATAATCACGT 1200

TAGACTTCAG ACCTCTGGGG ATTCTTTCCG TGTCCTGAAA GAGAATTTTT AAATTATTTA 1260

ATAAGAAAAA ATTTATATTA ATGATTGTTT CCTTTAGTAA TTTATTGTTC TGTACTGATA 1320

TTTAAATAAA GAGTTCTATT TCCCAAAAAA AAAAAAAAAA A

Seq ID NO: 265 Protein sequence: Protein Accession ft: BAB61048.1 1 11 21 31 41 51

I I I I I I

MAAAAATKIL LCLPLLLLLS GWSRAGRADP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT 60

FLHYDCGNKT VTPVSPLGKK LNVTTAWKAQ NPVLREWDI LTEQLRDIQL ENYTPKEPLT 120

LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL FDSEKRMWTT VHPGARKMKE KWENDKWAM 180

SFHYFSMGDC IGWLEDFLMG MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC 240 FILPGI

Seq ID NO: 266 DNA sequence

Nucleic Acid Accession ft: XM_084853.1

Coding sequence: 127-444

1 11 21 31 41 51

A ITTGATGATA TIATTTAACGA AIATCAAATTT GIGTGAATATG TIGGACACTGG AIAAGCTAATC 60

GACAAGATCA ACTTACCAGA TTTCCTAAAA GTGTACCTTA ACCACAAGCC ACCTTTTGGT 120

AACACCATGA GTGGCATCCA CAAGAGCTTT GAGGTGCTCG GTTATACCAA CTCCAAAGGG 180

AAAAAGGCCA TTCGAAGAGA GGACTTCCTG AGACTGCTCG TTACTAAAGG TGAGCATATG 240

ACGGAGGAGG AGATGTTGGA TTGCTTTGCT TCACTGTTTG GCCTGAATCC CGAGGGATGG 300

AAATCCGAGC CTGCAACCTG CTCCGTCAAA GGTTCAGAAA TTTGCCTTGA AGAAGAACTT 360

CCAGACGAAA TCACTGCAGA AATATTCGCG ACTGAAATTC TTGGCTTAAC CATTTCAGAA 420

GATTCCGGCC AGGATGGTCA GTGAAGTTAC CAGGAATGTT TAAAGCACAA AGGACTTTGG 480

GTGTGTGTGC ATGCACATGT GTGTGTTTTC CATGAGGCAC TGCTTTTTAT GCATTTCCCT 540 CCCCCCTCTC ATCTTTAGAA CATTTAGACA TTAAAGCAAG TTTCTGGTGA GCAATG

Seq ID NO: 267 Protein sequence: Protein Accession ft: XP_084853.1

1 11 21 31 41 51

I I I I I I

MSGIHKSFEV LGYTNSKGKK AIRREDFLRL LVTKGEHMTE EEMLDCFASL FGLNPEGWKS 60 EPATCSVKGS EICLEEELPD EITAEIFATE ILGLTISEDS GQDGQ

Seq ID NO: 268 DNA sequence Nucleic Acid Accession ft: NM_001898 Coding sequence: 57-482

31 41 51

GGCTCTCACC CTCCTCTCCT GCAGCTCCAG CTTTGTGCTC TGCCTCTGAG GAGACCATGG 60

CCCAGTATCT GAGTACCCTG CTGCTCCTGC TGGCCACCCT AGCTGTGGCC CTGGCCTGGA 120

GCCCCAAGGA GGAGGATAGG ATAATCCCGG GTGGCATCTA TAACGCAGAC CTCAATGATG 180

AGTGGGTACA GCGTGCCCTT CACTTCGCCA TCAGCGAGTA TAACAAGGCC ACCAAAGATG 240

ACTACTACAG ACGTCCGCTG CGGGTACTAA GAGCCAGGCA ACAGACCGTT GGGGGGGTGA 300

ATTACTTCTT CGACGTAGAG GTGGGCCGCA CCATATGTAC CAAGTCCCAG CCCAACTTGG 360

ACACCTGTGC CTTCCATGAA CAGCCAGAAC TGCAGAAGAA ACAGTTGTGC TCTTTCGAGA 420

TCTACGAAGT TCCCTGGGAG AACAGAAGGT CCCTGGTGAA ATCCAGGTGT CAAGAATCCT 480

AGGGATCTGT GCCAGGCCAT TCGCACCAGC CACCACCCAC TCCCACCCCC TGTAGTGCTC 540

CCACCCCTGG ACTGGTGGCC CCCACCCTGC GGGAGGCCTC CCCATGTGCC TGCGCCAAGA 600

GACAGACAGA GAAGGCTGCA GGAGTCCTTT GTTGCTCAGC AGGGCGCTCT GCCCTCCCTC 660

CTTCCTTCTT GCTTCTAATA GCCCTGGTAC ATGGTACACA CCCCCCCACC TCCTGCAATT 720 AAACAGTAGC ATCGCC

Seq ID NO: 269 Protein sequence: Protein Accession #:NP_001889.1

1 11 21 31 41 51

1 I I I I I

MAQYLSTLLL LLATLAVALA WSPKEEDRII PGGIYNADLN DEWVQRALHP AISEYNKATK 60

DDYYRRPLRV LRARQQTVGG VNYFFDVEVG RTICTKSQPN LDTCAFHEQP ELQKKQLCSF 120 EIYEVPWENR RSLVKSRCQE S

Seq ID NO: 270 DNA sequence Nucleic Acid Accession ft: XM 093210

Coding sequence: 13-1854

1 11 21 31 41 51

A ITGGCAAGCG CICGGAATCTC CITCAGCTGCC GITTTCACAAA AIGAGGTACCA GIGTCCGCACC 60

AAACGAGCAC ACAAGCAGCA CCAGGAGCTG CAGAAGAAGG AGGCGGCAGC GATGGACCAG 120

GGCAGAGGGA ATGGGGAGGG GGCATCCTAC CCCATATCTG AGGTGCGACT GCGGGACGTA 180

GAGCGGACTG GGCCTTTCCC GTTGGCGCGT GGCCTCAATC AGGACTTCTT GCCCACGTGC 240

GCCTTCAAAA CGGTAAGAGC TGCAACTGAA CGTGTGAGAC ATGGTGCAGA TAGGCTGAGA 300

GGCGGCGGGA GAGATGCCCA TGAACTCAAG TACCCGGACA CGCCCTCCAC TTCTACCACC 360

ACGAGTAACA CCGCCCCCAC GGGACCGCTC TCGAGGTCCC CCAAGCCAAG GACGCAAGGA 420

GGAACGCCCC GGCGCGCGGC CAGCAGCGGC GGGCACCGGC CCAATGGCCA CGGAACTCAG 480

CACTGGCAGT CGGCCCTCCT CACACCGCAG GCGTGCAGTG TGGCCGACGG AGCCTCCCGG 540

GCCGAGGACC CAGCTAGGCC GTCACCCCGG TTGCTCCCAC GGGAAGGGGC ACCAGGCAAA 600

CTGCCCAAGG CCCCGAGCCC AGGCTCCCTG GCGGAGGCCT CCGCTGGTCC CGCCCAGATC 660

ATGGCCGCCA CCAGGCTCCC GAGCCATGGC TTCCTGTCCG GGAACGGCCC GGCGTCCTGG 720 CTGTCCAGCT AG

Seq ID NO: 271 Protein sequence: Protein Accession ft: XP_093210

11 21 31 I I I I I

MLRHGEQKRK RARKKWDFLP TCAFKTVRAA TERVRHGADR LRGGGRDAHE LKYPDTPSTS 60

TTTSNTAPTG PLSRSPKPRT QGGTPRRRPA AAGTRANGHG TQHWQSALLT PQACSVADGA 120

SRAEDPARPS PRLLPREGAP GKLPKAPSPG SLAEASAGLL AHVRLQNADA QRVSISQALP 180

PNSSVGRKEE RPGAGQQRRA PAPMATELST GSRPSSHRRR AVWPTEPPGP RTQLEPSPRL 240 LPREGAPGKL PKAPSPGSLA EASAGPAQIM AATRLPSRGF LSGNGPASWL SS

Seq ID NO: 272 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 1..732

1 11 21 31 41 51

I I I I I I

GGATACTGTG TCACTCAAAG TAATGGGAGG GAGAGAGAAC AGGGAGGGTA GGGATGCTTT 60

TGAAAAAGCT TTTTTTCCCA CTTTTAACTT GCTTTAGCGT TAAGAGTACT TACCAGCTAA 120

TAATGTGGAG GAAATTATTC TTTCTCATTG GAGATTACAG AATATATCTA TTCATCTTGA 180

ATACCCACTT GAAGCCTCTG TAGAAATGTC TCGTCCTCCG GTTGTATTTC TAAAACCTAC 240

ATGATTTTGT CTTGTTTCTG CAGTGAGAAA TTACATCCAT AGCAAAGACA AAAGTCTTTT 300

TAAATTATTT TTATTTATCT TTCATATAGT TCTTACAATT TCTAAAAAAT TAACACTCAT 360

TTAGTATCAC AATTTATGGG AGAGGGTTTT TTGTATTTTT AAGCATATGT GGCTTATATA 420

AAAATTGCAG AAGTCATAGG ACTGTCATGT ATTGCAGCTC TGAGAACCAA TGCCTGAAAC 480 TTAAGCC

Seq ID NO: 273 Protein sequence: Protein Accession ft: Eos sequence

1 11 21 31 41 51

I I I I I I

MGGRENREGR DAFEKAFFPT FNLL

Seq ID NO: 274 DNA sequence

Nucleic Acid Accession ft: NM_003976.2

Coding sequence: 299-961

1 11 21 31 41 51

C ITCTGAGCTT CITCTGAGCCT TIGTTTGCTCA TICTGGAAAAA GIGGGATTAAA CICATTTACCT 60

CATGGAGTTG TGAAAGAATA GCTGCAAAGC ACCTAACACA TAGTAAGGTT CCCAGTGCAG 120

CTACTTCTGC TGGGTTGAGT CTAGCTGTGT AGGCCCCTTG TTCCTCACCT GGAGAAACTG 180

GGGTGGCAGG CCGGTCCCCC ACAAAAGATA ACTCATCTCT TAATTTGCAA GCTGCCTCAA 240

CAGGAGGGTG GGGGAACAGC TCAACAATGG CTGATGGGCG CTCCTGGTGT TGATAGAGAT 300

GGAACTTGGA CTTGGAGGCC TCTCCACGCT GTCCCACTGC CCCTGGCCTA GGCGGCAGCC 360

TGCCCTGTGG CCCACCCTGG CCGCTCTGGC TCTGCTGAGC AGCGTCGCAG AGGCCTCCCT 420

GGGCTCCGCG CCCCGCAGCC CTGCCCCCCG CGAAGGCCCC CCGCCTGTCC TGGCGTCCCC 480

CGCCGGCCAC CTGCCGGGGG GACGCACGGC CCGCTGGTGC AGTGGAAGAG CCCGGCGGCC 540

GCCGCCGCAG CCTTCTCGGC CCGCGCCCCC GCCGCCTGCA CCCCCATCTG CTCTTCCCCG 600

CGGGGGCCGC GCGGCGCGGG CTGGGGGCCC GGGCAGCCGC GCTCGGGCAG CGGGGGCGCG 660

GGGCTGCCGC CTGCGCTCGC AGCTGGTGCC GGTGCGCGCG CTCGGCCTGG GCCACCGCTC 720

CGACGAGCTG GTGCGTTTCC GCTTCTGCAG CGGCTCCTGC CGCCGCGCGC GCTCTCCACA 780

CGACCTCAGC CTGGCCAGCC TACTGGGCGC CGGGGCCCTG CGACCGCCCC CGGGCTCCCG 840

GCCCGTCAGC CAGCCCTGCT GCCGACCCAC GCGCTACGAA GCGGTCTCCT TCATGGACGT 900

CAACAGCACC TGGAGAACCG TGGACCGCCT CTCCGCCACC GCCTGCGGCT GCCTGGGCTG 960

AGGGCTCGCT CCAGGGCTTT GCAGACTGGA CCCTTACCGG TGGCTCTTCC TGCCTGGGAC 1020

CCTCCCGCAG AGTCCCACTA GCCAGCGGCC TCAGCCAGGG ACGAAGGCCT CAAAGCTGAG 1080

AGGCCCCTAC CGGTGGGTGA TGGATATCAT CCCCGAACAG GTGAAGGGAC AACTGACTAG 1140

CAGCCCCAGA GCCCTCACCC TGCGGATCCC AGCCTAAAAG ACACCAGAGA CCTCAGCTAT 1200

GGAGCCCTTC GGACCCACTT CTCACAGACT CTGGCACTGG CCAGGCCTCG AACCTGGGAC 1260

CCCTCCTCTG ATGAACACTA CAGTGGCTGA GGCATCAGCC CCCGCCCAGG CCCTGTAGGG 1320

ACAGCATTTG AAGGACACAT ATTGCAGTTG CTTGGTTGAA AGTGCCTGTG CTGGAACTGG 1380 CCTGTACTCA CTCATGGGAG CTGGCCCC

Seq ID NO: 275 Protein sequence: Protein Accession ft: NP_003967.1

1 11 21 31 41 51

I I I I I I

MELGLGGLST LSHCPWPRRQ PALWPTLAAL ALLSSVAEAS LGSAPRSPAP REGPPPVLAS 60

PAGHLPGGRT ARWCSGRARR PPPQPSRPAP PPPAPPSALP RGGRAARAGG PGSRARAAGA 120

RGCRLRSQLV PVRALGLGHR SDELVRFRFC SGSCRRARSP HDLSLASLLG AGALRPPPGS 180 RPVSQPCCRP TRYEAVSFMD VNSTWRTVDR LSATACGCLG

Seq ID NO: 276 DNA sequence

Nucleic Acid Accession ft: NM_057091.1

Coding sequence: 783-1445

1 11 21 31 41 51

I I I I I I

ACTGGCCGCT GAGAGAAGAA TCGGGTGGAG CAGAGAGCAG CTGCTGCAGG GCAGACAGCC 60

GGACCCCCAA ATCTGCACGT ACCAGCAGTC AGCCGCCCCA CGCAGGGACC GGCTTACCCC 120

TCGCTCCCCG CCCTCACTCA CTTTCTCCCG CCCTCGGCCC GGCCTCCCAG CTCTCTACTT 180

CGCGTGTCTA CAAACTCAAC TCCCGGTTTC CGTGCCTCTC CACCGCTCGA GTTCTCTACT 240

CTCCATATCC GAGGGGCCCC TCCCAGCATC TACCCCCCTC CCAACCTCGG GGGACCTAGC 300

CAAGCTAGGG GGGACTGGAT CCGACGGGTG GAGCAGCCAG GTGAGCCCCG AAAGGTGGGG 360

CGGGGCAGGG GCGCTCCCAG CCCCACCCCG GGATCTGGTG ACGCTGGGGC TGGAATTTGA 420

CACCGGACGG CTGCGGCGGC GGGCAGGAGG CTGCTGAGGG ATGGAGTTGG GCCCGGCCCC 480

CAGACAAGGC CCGGGGGCTC CGCCAGCAGC AGGTCCCTCG GGCCCCAGCC CTCGCTGCCA 540 CCCGGGCCTG GAGCCCCACA CCCGAGGGTG CAGACTGGCT GCCAAGGCCA CACTTTTGGC 600

TAAAAGAGGC ACTGCCAGGT GTACAGTCCT GGGCATGCGC TGTTTGAGCT TCGGGGGAGA 660

GCCCAGGACT GGTCCCCGGA AAGGTGCCTA GAAGAACAAG GTGCAGGACC CCGTGCTGCC 720

TCAACAGGAG GGTGGGGGAA CAGCTCAACA ATGGCTGATG GGCGCTCCTG GTGTTGATAG 780

AGATGGAACT TGGACTTGGA GGCCTCTCCA CGCTGTCCCA CTGCCCCTGG CCTAGGCGGC 840

AGCCTGCCCT GTGGCCCACC CTGGCCGCTC TGGCTCTGCT GAGCAGCGTC GCAGAGGCCT 900

CCCTGGGCTC CGCGCCCCGC AGCCCTGCCC CCCGCGAAGG CCCCCCGCCT GTCCTGGCGT 960

CCCCCGCCGG CCACCTGCCG GGGGGACGCA CGGCCCGCTG GTGCAGTGGA AGAGCCCGGC 1020

GGCCGCCGCC GCAGCCTTCT CGGCCCGCGC CCCCGCCGCC TGCACCCCCA TCTGCTCTTC 1080

10 CCCGCGGGGG CCGCGCGGCG CGGGCTGGGG GCCCGGGCAG CCGCGCTCGG GCAGCGGGGG 1140

CGCGGGGCTG CCGCCTGCGC TCGCAGCTGG TGCCGGTGCG CGCGCTCGGC CTGGGCCACC 1200

GCTCCGACGA GCTGGTGCGT TTCCGCTTCT GCAGCGGCTC CTGCCGCCGC GCGCGCTCTC 1260

CACACGACCT CAGCCTGGCC AGCCTACTGG GCGCCGGGGC CCTGCGACCG CCCCCGGGCT 1320

CCCGGCCCGT CAGCCAGCCC TGCTGCCGAC CCACGCGCTA CGAAGCGGTC TCCTTCATGG 1380

15 ACGTCAACAG CACCTGGAGA ACCGTGGACC GCCTCTCCGC CACCGCCTGC GGCTGCCTGG 1440

GCTGAGGGCT CGCTCCAGGG CTTTGCAGAC TGGACCCTTA CCGGTGGCTC TTCCTGCCTG 1500

GGACCCTCCC GCAGAGTCCC ACTAGCCAGC GGCCTCAGCC AGGGACGAAG GCCTCAAAGC 1560

TGAGAGGCCC CTACCGGTGG GTGATGGATA TCATCCCCGA ACAGGTGAAG GGACAACTGA 1620

CTAGCAGCCC CAGAGCCCTC ACCCTGGGGA TCCCAGCCTA AAAGACACCA GAGACCTCAG 1680 0 CTATGGAGCC CTTCGGACCC ACTTCTCACA GACTCTGGCA CTGGCCAGGC CTCGAACCTG 1740

GGACCCCTCC TCTGATGAAC ACTACAGTGG CTGAGGCATC AGCCCCCGCC CAGGCCCTGT 1800

AGGGACAGCA TTTGAAGGAC ACATATTGCA GTTGCTTGGT TGAAAGTGCC TGTGCTGGAA 1860 CTGGCCTGTA CTCACTCATG GGAGCTGGCC CC 5 Seq ID NO: 277 Protein sequence: Protein Accession ft: NP_003967.1 1 11 21 31 41 51

M IELGLGGLST LISHCPWPRRQ PIALWPTLAAL AILLSSVAEAS LIGSAPRSPAP RIEGPPPVLAS 60 0 PAGHLPGGRT ARWCSGRARR PPPQPSRPAP PPPAPPSALP RGGRAARAGG PGSRARAAGA 120

RGCRLRSQLV PVRALGLGHR SDELVRFRFC SGSCRRARSP HDLSLASLLG AGALRPPPGS 180 RPVSQPCCRP TRYEAVSFMD VNSTWRTVDR LSATACGCLG

Seq ID NO: 278 DNA sequence 5 Nucleic Acid Accession ft: NM 057160.1

Coding sequence: 1-714

1 11 21 31 41 51

I I I I I I 0 ATGCCCGGCC TGATCTCAGC CCGAGGACAG CCCCTCCTTG AGGTCCTTCC TCCCCAAGCC 60

CACCTGGGTG CCCTCTTTCT CCCTGAGGCT CCACTTGGTC TCTCCGCGCA GCCTGCCCTG 120

TGGCCCACCC TGGCCGCTCT GGCTCTGCTG AGCAGCGTCG CAGAGGCCTC CCTGGGCTCC 180

GCGCCCCGCA GCCCTGCCCC CCGCGAAGGC CCCCCGCCTG TCCTGGCGTG CCCCGCCGGC 240

CACCTGCCGG GGGGACGCAC GGCCCGCTGG TGCAGTGGAA GAGCCCGGCG GCCGCCGCCG 300 5 CAGCCTTCTC GGCCCGCGCC CCCGCCGCCT GCACCCCCAT CTGCTCTTCC CCGCGGGGGC 360

CGCGCGGCGC GGGCTGGGGG CCCGGGCAGC CGCGCTCGGG CAGCGGGGGC GCGGGGCTGC 420

CGCCTGCGCT CGCAGCTGGT GCCGGTGCGC GCGCTCGGCC TGGGCCACCG CTCCGACGAG 480

CTGGTGCGTT TCCGCTTCTG CAGCGGCTCC TGCCGCCGCG CGCGCTCTCC ACACGACCTC 540

AGCCTGGCCA GCCTACTGGG CGCCGGGGCC CTGCGACCGC CCCCGGGCTC CCGGCCCGTC 600 0 AGCCAGCCCT GCTGCCGACC CACGCGCTAC GAAGCGGTCT CCTTCATGGA CGTCAACAGC 660

ACCTGGAGAA CCGTGGACCG CCTCTCCGCC ACCGCCTGCG GCTGCCTGGG CTGAGGGCTC 720

GCTCCAGGGC TTTGCAGACT GGACCCTTAC CGGTGGCTCT TCCTGCCTGG GACCCTCCCG 780

CAGAGTCCCA CTAGCCAGCG GCCTCAGCCA GGGACGAAGG CCTCAAAGCT GAGAGGCCCC 840

TACCGGTGGG TGATGGATAT CATCCCCGAA CAGGTGAAGG GACAACTGAC TAGCAGCCCC 900 5 AGAGCCCTCA CCCTGCGGAT CCCAGCCTAA AAGACACCAG AGACCTCAGC TATGGAGCCC 960

TTCGGACCCA CTTCTCACAG ACTCTGGCAC TGGCCAGGCC TCGAACCTGG GACCCCTCCT 1020

CTGATGAACA CTACAGTGGC TGAGGCATCA GCCCCCGCCC AGGCCCTGTA GGGACAGCAT 1080

TTGAAGGACA CATATTGCAG TTGCTTGGTT GAAAGTGCCT GTGCTGGAAC TGGCCTGTAC 1140 TCACTCATGG GAGCTGGCCC C 0

Seq ID NO: 279 Protein sequence: Protein Accession ft: NP 476501.1

, _ 1 11 21 31 41 51 5 i i i i i i

MPGLISARGQ PLLEVLPPQA HLGALFLPEA PLGLSAQPAL WPTLAALALL SSVAEASLGS 60

APRSPAPREG PPPVLASPAG HLPGGRTARW CSGRARRPPP QPSRPAPPPP APPSALPRGG 120

RAARAGGPGS RARAAGARGC RLRSQLVPVR ALGLGHRSDE LVRFRFCSGS CRRARSPHDL 180 SLASLLGAGA LRPPPGSRPV SQPCCRPTRY EAVSFMDVNS TWRTVDRLSA TACGCLG 0

Seq ID NO: 280 DNA sequence

Nucleic Acid Accession ft: NM_057090.1

Coding sequence: 29-715 5 1 11 21 31 41 51

I I I I I I

CTGATGGGCG CTCCTGGTGT TGATAGAGAT GGAACTTGGA CTTGGAGGCC TCTCCACGCT 60

GTCCCACTGC CCCTGGCCT GGCGGCAGGC TCCACTTGGT CTCTCCGCGC AGCCTGCCCT 120

GTGGCCCACC CTGGCCGCTC TGGCTCTGCT GAGCAGCGTC GCAGAGGCCT CCCTGGGCTC 180 0 CGCGCCCCGC AGCCCTGCCC CCCGCGAAGG CCCCCCGCCT GTCCTGGCGT CCCCCGCCGG 240

CCACCTGCCG GGGGGACGCA CGGCCCGCTG GTGCAGTGGA AGAGCCCGGC GGCCGCCGCC 300

GCAGCCTTCT CGGCCCGCGC CCCCGCCGCC TGCACCCCCA TCTGCTCTTC CCCGCGGGGG 360

CCGCGCGGCG CGGGCTGGGG GCCCGGGCAG CCGCGCTCGG GCAGCGGGGG CGCGGGGCTG 420

CCGCCTGCGC TCGCAGCTGG TGCCGGTGCG CGCGCTCGGC CTGGGCCACC GCTCCGACGA 480 5 GCTGGTGCGT TTCCGCTTCT GCAGCGGCTC CTGCCGCCGC GCGCGCTCTC CACACGACCT 540

CAGCCTGGCC AGCCTACTGG GCGCCGGGGC CCTGCGACCG CCCCCGGGCT CCCGGCCCGT 600

CAGCCAGCCC TGCTGCCGAC CCACGCGCTA CGAAGCGGTC TCCTTCATGG ACGTCAACAG 660 CACCTGGAGA ACCGTGGACC GCCTCTCCGC CACCGCCTGC GGCTGCCTGG GCTGAGGGCT 720 CGCTCCAGGG CTTTGCAGAC TGGACCCTTA CCGGTGGCTC TTCCTGCCTG GGACCCTCCC 780 GCAGAGTCCC ACTAGCCAGC GGCCTCAGCC AGGGACGAAG GCCTCAAAGC TGAGAGGCCC 840 CTACCGGTGG GTGATGGATA TCATCCCCGA ACAGGTGAAG GGACAACTGA CTAGCAGCCC 900 CAGAGCCCTC ACCCTGCGGA TCCCAGCCTA AAAGACACCA GAGACCTCAG CTATGGAGCC 960 CTTCGGACCC ACTTCTCACA GACTCTGGCA CTGGCCAGGC CTCGAACCTG GGACCCCTCC 1020 TCTGATGAAC ACTACAGTGG CTGAGGCATC AGCCCCCGCC CAGGCCCTGT AGGGACAGCA 1080 TTTGAAGGAC ACATATTGCA GTTGCTTGGT TGAAAGTGCC TGTGCTGGAA CTGGCCTGTA 1140 CTCACTCATG GGAGCTGGCC CC

Seq ID NO: 281 Protein sequence: Protein Accession ft: NP_476431.1

1 11 21 31 41 51

I I I I I I

MELGLGGLST LSHCPV1PRRQ APLGLSAQPA LWPTLAALAL LSSVAEASLG SAPRSPAPRE 60 GPPPVLASPA GHLPGGRTAR WCSGRARRPP PQPSRPAPPP PAPPSALPRG GRAARAGGPG 120 SRARAAGARG CRLRSQLVPV RALGLGHRSD ELVRFRFCSG SCRRARSPHD LSLASLLGAG 180 ALRPPPGSRP VSQPCCRPTR YEAVSFMDVN STWRTVDRLS ATACGCLG

Seq ID NO: 282 DNA sequence

Nucleic Acid Accession ft: Eos sequence

11 21 31 41 51

I I I I I

CTACTGCACC TGCCCTCTGT TTGCTTTGGA AATCTCTTAC CTTTCATTAG GGTTTCTTTC 60 ATAGCAATTT CCTTTGGTTT TTAAGACTTC TACATTGCTT TTTCTTTTAT TATCTGTGCT 120 CCGTGAACCT TATGAATGCT GCTTAAAAAT AATGTCAAAA TATGTTTTAG CTGCCTACTC 180 AGGTAACGTT TTCTTTTGCT CTCATCTTGG TTTCCATATA CTATTTTTGG TTTTTTGTGA 240 GATCTAATCA ATGATCTAGT CAGAAGCTAC TTCACTGGCT AACAGTGATC ATGTTCATGT 300 GCTAAAAATG AACTTGAAAC ACGGAAGTAG TGGTTGGTCC AGTTTGAAAG CTCTTATTAG 360 TATTCTTCAT CCTGGCTGTA ATAATAGCCA TTATTTGTTA TGCCTTTGTT ATGTAGCAGA 420 CACTCTTAAG GATTTTATGT GTATTATTCA AATTGCTATT ACTGTTCTTT TTATAGTTGA 480 GAATCTCAGG ATACCTACAT TTATCACTTT TTCAATATAT ATGTATTTCT TATT

Seq ID NO: 283 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 564-1481

11 21 31 51

GAGACTTTTA ATCATCTATC CCTTGTGCTT TACGCAGACC CTACAATACA CTAGAGGCTT 60 CAAAGAGGTC AAAAATTCAC ATGTGTAGAC AAATTAGGTC CCTTAAGATG CCAGGCAAAC 120 GAAGTGCTAC CAAAACACGC AATGACTGTC CTAAAAGTGC GTTCTGGGAT ACACCTGTAA 180 ACTTGGATCA AGTTCCCTCC CCTCTCCTCA AAATATATCG ACTTGTGCTG AAAGAAATCA 240 CGACCGATGC TCACAATTCT GACCTCGTAA TTATATAGGG GGTGGTTTTG GTTTCTGCGT 300 CTTTCCCTGA TTCAGTGGCA GGTAACATAT TTCATGTACA AAATGAACTG CAACACCACG 360 GCAAACAAGG GACAGGCCCT CAAAGTTGTC GGTAGGGAGC CAGGACCCCG CCAGTGGCGT 420 GGGGAGACAC CGTACTAAAC AAGCTTGCAA ACAGCAGGCA CCTTCCTGCC ACTGAGGAGG 480 AAGGGCTGGC TAAGGGAGGC CGGGGCGGAG GAAGCCAAGC TCTGCAGGCC CTGACAAAGT 540 CCTCCCGGCC TCCACGCGTC GCCATGGCAA CGCGGGGTCT GTGCTGGCCG GGATTGGCCG 600 GCCTGGCGCG CGCAGGGCCC GCTGGGAAAG CGCGTCCCCG CCGCGGCTCC GCCAGTTTGA 660 ACTTGGCGGG CCAGATGTGG GCGGCGGGGC GCTGGGGGCC TACTTTTCCC TCTTCCTACG 720 CCGGTTTCTC TGCTGACTGC AGACCCAGGT CTCGGCCCTC CTCGGACTCC TGCTCAGTCC 780 CTATGACGGG CGCACGTGGG CAGGGGCTGG AGGTGGTGCG CTCGCCGTCG CCGCCGCTGC 840 CGCTGAGCTG CAGCAATTCC ACCAGGTCGC TGTTGTCTCC CCTTGGCCAC CAGAGCTTCC 900 AGTTTGACGA GGACGACGGT GACGGGGAGG ATGAGGAAGA CGTGGATGAT GAGGAAGACG 960 TGGATGAAGA TGCCCATGAT TCAGAGGCCA AAGTGGCGAG CCTGAGAGGA ATGGAGTTAC 1020 AGGGGTGCGC CAGCACTCAG GTTGAATCAG AAAATAACCA AGAAGAACAG AAACAGGTGC 1080 GCTTACCAGA AAGCCGCCTG ACACCATGGG AGGTGTGGTT TATTGGCAAA GAAAAAGAAG 1140 AACGTGACCG GCTGCAACTG AAAGCTCTAG AGGAATTAAA TCAACAACTA GAAAAAAGAA 1200 AAGAAATGGA AGAACGTGAA AAAAGAAAGA TAATTGCTGA AGAAAAGCAC AAGGAATGGG 1260 TTCAGAAAAA GAATGAGCAA AAAAGAAAAG AAAGAGAACA AAAAATTAAT AAAGAAATGG 1320 AGGAAAAAGC AGCAAAGGAA CTGGAGAAAG AATACTTGCA AGAAAAAGCA AAAGAAAAAT 1380 ATCAAGAATG GTTAAAGAAA AAAAATGCTG AAGAATGTGA GAGGAAGAAG AAAGAAAAGA 1440 AAAACAACAG CAAGCTGAAA TACAGGAGAA AAAGGAAATA GCAGAAAAAA AGTTTCAAGA 1500 ATGGTTGGAA AATGCGAAAC ATAAACCTCG TCCAGCTGCA AAGAGCTATG GTTATGCCAA 1560 TGGAAAACTT ACAGGTTTTT ACAGTGGAAA TTCCTATCCA GAACCAGCCT TTTATAATCC 1620 AATTCCGTGG AAACCAATTC ATATGCCACC TCCCAAAGAA GCTAAGGATC TATCAGGAAG 1680 GAAGAGTAAA AGACCTGTGA TAAGTCAGCC ACACAAGTCA TCATCTCTGG TAATTCATAA 1740 AGCCAGGAGC AATCTTTGCC TTGGAACTCT GTGCAGAATA CAAAGATAGC GTATGTGGAA 1800 AATAACATGC TTTTATCTGG AGCTATTTAA TTTAAAAATC AGAAATTGTT TTTTACTGCT 1860 CAGTCAATAA CTCAACACTT AATGTGATTA TTGACAAATA GCAATTTTTG CATTTGTATA 1920 TGGAGTCCTT AGAGTTGAGG AAGATATTTT CTGGATTTTG GTTTTTATAA ACTTTTTAAG 1980 GTTGATCTTG GCATGTTGTT TTGCAGAATA AGTGGCTGAA TATGTAAGAA TTGTGTTTGT 2040 ATTTAGCTTG TATTAAAAGT ACACTGTAAT ACCAATAAAA CTAACAATTT TTCTTG

Seq ID NO: 284 Protein sequence: Protein Accession ft: Eos sequence

11 31

MATRGLCWPG LAGLARAGPA GKARPRRGSA SLNLAGQMWA AGRWGPTFPS SYAGFSADCR 60 PRSRPSSDSC SVPMTGARGQ GLEWRSPSP PLPLSCSNST RSLLSPLGHQ SFQFDEDDGD 120 GEDEEDVDDE EDVDEDAHDS EAKVASLRGM ELQGCASTQV ESENNQEEQK QVRLPESRLT 180 PWEVWFIGKE KEERDRLQLK ALEELNQQLE KRKEMEEREK RKIIAEEKHK EWVQKKNEQK 240 RKEREQKINK EMEEKAAKEL EKEYLQEKAK EKYQEWLKKK NAEECERKKK EKKNNSKLKY 300 RRKRK

Seq ID NO : 285 DNA sequence

Nucleic Acid Accession ft : Eos sequence

Coding sequence : 1-1746

11 21 31 41 51

ATGCCACTGA A IGCATTATCT I I

CCTTTTGCTG GTGGGCTGCC A IAGCCTGGGG T IGCAGGGTTG 60 GCCTACCATG GCTGCCCTAG CGAGTGTACC TGCTCCAGGG CCTCCCAGGT GGAGTGCACC 120 GGGGCACGCA TTGTGGCGGT GCCCACCCCT CTGCCCTGGA ACGCCATGAG CCTGCAGATC 180 CTCAACACGC ACATCACTGA ACTCAATGAG TCCCCGTTCC TCAATATCTC AGCCCTCATC 240 GCCCTGAGGA TTGAGAAGAA TGAGCTGTCG CGCATCACGC CTGGGGCCTT CCGAAACCTG 300 GGCTCGCTGC GCTATCTCAG CCTCGCCAAC AACAAGCTGC AGGTTCTGCC CATCGGCCTC 360 TTCCAGGGCC TGGACAGCCT TGAGTCTCTC CTTCTGTCCA GTAACCAGCT GTTGCAGATC 420 CAGCCGGCCC ACTTCTCCCA GTGCAGCAAC CTCAAGGAGC TGCAGTTGCA CGGCAACCAC 480 CTGGAATACA TCCCTGACGG AGCCTTCGAC CACCTGGTAG GACTCACGAA GCTCAATCTG 540 GGCAAGAATA GCCTCACCCA CATCTCACCC AGGGTCTTCC AGCACCTGGG CAATCTCCAG 600 GTCCTCCGGC TGTATGAGAA CAGGCTCACG GATATCCCCA TGGGCACTTT TGATGGGCTT 660 GTTAACCTGC AGGAACTGGC TCTACAGCAG AACCAGATTG GACTGCTCTC CCCTGGTCTC 720 TTCCACAACA ACCACAACCT CCAGAGACTC TACCTGTCCA ACAACCACAT CTCCCAGCTG 780 CCACCCAGCA TCTTCATGCA GCTGCCCCAG CTCAACCGTC TTACTCTCTT TGGGAATTCC 840 CTGAAGGAGC TCTCTCTGGG GATCTTCGGG CCCATGCCCA ACCTGCGGGA GCTTTGGCTC 900 TATGACAACC ACATCTCTTC TCTACCCGAC AATGTCTTCA GCAACCTCCG CCAGTTGCAG 960 GTCCTGATTC TTAGCCGCAA TCAGATCAGC TTCATCTCCC CGGGTGCCTT CAACGGGCTA 1020 ACGGAGCTTC GGGAGCTGTC CCTCCACACC AACGCACTGC AGGACCTGGA CGGGAATGTC 1080 TTCCGCATGT TGGCCAACCT GCAGAACATC TCCCTGCAGA ACAATCGCCT CAGACAGCTC 1140 CCAGGGAATA TCTTCGCCAA CGTCAATGGC CTCATGGCCA TCCAGCTGCA GAACAACCAG 1200 CTGGAGAACT TGCCCCTCGG CATCTTCGAT CACCTGGGGA AACTGTGTGA GCTGCGGCTG 1260 TATGACAATC CCTGGAGGTG TGACTCAGAC ATCCTTCCGC TCCGCAACTG GCTCCTGCTC 1320 AACCAGCCTA GGTTAGGGAC GGACACTGTA CCTGTGTGTT TCAGCCCAGC CAATGTCCGA 1380 GGCCAGTCCC TCATTATCAT CAATGTCAAC GTTGCTGTTC CAAGCGTCCA TGTCCCTGAG 1440 GTGCCTAGTT ACCCAGAAAC ACCATGGTAC CCAGACACAC CCAGTTACCC TGACACCACA 1500 TCCGTCTCTT CTACCACTGA GCTAACCAGC CCTGTGGAAG ACTACACTGA TCTGACTACC 1560 ATTCAGGTCA CTGATGACCG CAGCGTTTGG GGCATGACCC AGGCCCAGAG CGGGCTGGCC 1620 ATTGCCGCCA TTGTAATTGG CATTGTCGCC CTGGCCTGCT CCCTGGCTGC CTGCGTCGGC 1680 TGTTGCTGCT GCAAGAAGAG GAGCCAAGCT GTCCTGATGC AGATGAAGGC ACCCAATGAG 1740 TGTTAAAGAG GCAGGCTGGA GCAGGGCTGG GGAATGATGG GACTGGAGGA CCTGGGAATT 1800 TCATCTTTCT GCCTCCACCC CTGGGTCCAT GGAGCTTTCC CGTGATTGCT CTTTCTGGCC 1860 CTAGATAAAG GTGTGCCTAC CTCTTCCTGA CTTGCCTGAT TCTCCCGTAG AGAAGCAGGT 1920 CGTGCCGGAC CTTCCTACAA TCAGGAAGAT AGATCCAACT GGCCATGGCA AAAGCCCTGG 1980 GGATTTCCGA TTCATACCCC TGGGCTTCCT TCGAGAGGGC TCTTCCTCCA AATCCTCCCC 2040 ACCTGTCCTC CAAGAACAGC CTTCCCTGCG CCCAGGCCCC CTCCGGGCCT CTGTAGACTC 2100 AGTTAGTCCA CAGCCTGCTC ACTTCGTGGG AATAGTTCTC CGCTGAGATA GCCCCTCTCG 2160 CCTAAGTATT ATGTAAGTTG ATTTCCCTTC TTTTGTTTCT CTTGTTTGTG CTATGGCTTG 2220 ACCCAGCATG TCCCCTCAAA TGAAAGTTCT CCCCTTGATT TTCTGCTCCT GAAGGCAGGG 2280 TGAGTTCTCT CCTCAAAGAA GACTTCAAAC CATTTAACTG GTTTCTTAAG AGCCGTCAAT 2340 CAGCCTGGTT TTGGGGATGC TATGAAAGAG AGAAGGAAAA TCATGCCGCT CAGTTCCTGG 2400 AGACAGAAGA GCCGTCATCA GTGTCTCACT TGTGATTTTT ATCTGGAAAA GGAAGAAACA 2460 CCCCAGCACA GCAAGCTCAG CCTTTTAGAG AAGGATATTT CCAAACTGCA AACTTTGCTT 2520 TGAAAAGTTT AGCCCTTTAA GGAATGAAAT CATGTAGAAT TTTGGACTTC TAAAAACATT 2580 AAAATCAGCT TATTAATACG GGATAGAGAA AGAAATCTGG TGCCTGGGGG TCCCTGTGTT 2640 CACCCCTAGA GTTTGTTTTA AAATTTTTAA TTGAAGCATG TGAAGTGTAC STGCAGAAAA 2700 GTGGGAACAT GATAGTGTAT GGCTTGGTGG ATTTTCACAA ACTGAACATA CCTGTGTAAT 2760 CAGCATCTAG ACCCAGACCC AGAGCATCAC AAATATCCCC CATCCTGGGC TTTTCCCAGA 2820 GGAGATGGGG GCTTCTGAAG ATGGACTTAC CTGGGACCTG CCCCCCATGA GCCAGGACGG 2880 TCCCCCCACA GTCAGCCTGT GCAAAGGCCC CGTGGCCAGG GGTGGAGGAG AATATGTGGG 2940 TGTGGACAGG ATGGGAGACT GTGGCCTGAA CAGGAGATTT TATTATATCT GGAGACCCTG 3000 AGAGACCCTG AGACCTGGGG CACCATGGCT GGCCAGGTCA GAAGCATCCT GACTGCAGAG 3060 GTCCGTGCAG CCACACCCTC TTCCCTGCCA GCAAGTTGTC TGCGGCTCAT CGGAGGCCCC 3120 TCCGCCTGGA GCCTTCTATG GACGTGATAT GCCTGTATCT GTTTTTAATT TTCATTCTTC 3180 ACTTAGGGGA AGTGAAATCG CTCAGAGATG AGATCCTTTA ATTGAAAACG AAGTGTAACG 3240 GAATCTAGTG TCTTTCTAAT GTGGTAAAAT TCTCCATCAA CATCACAGTC AGCTGGCAGC 3300 TGAACTTCAG AATCTCACTT ACAGCAGGCG ACACGGGGGT ACACCGATGG GTCACACTGG 3360 GTCTGGGGGC TCCCTGGAGC TCCTCCTGCG TGTGGTCTGG TTAGGAGTTG AGTTGTTTGC 3420 TCCAGGGTTA TTCTCCTCCT CGAGTCACAG TCACACGAAT ACCTGCCTTC TCTGGCTTTC 3480 CTGCTATACA CATATTCACA TGGCGCTCAA GAAGTTAGGC TCATGGCAAC GTGTGTCTTT 3540 CTCTGGACAA CTGGCCCAGT TTACAGTGAA ATGGAGAATT TCAGGTCTCC ACGTCTGCCC 3600 AGGAAAGAAC TTCAGCTGAC TCCACGGGGA TCTGGAAATC CACGACCAAT CCCGATCGGC 3660 TCTTATTAGC TCCCCGCTCC ACAAGACACC TGTGCTTTGG AAATCCACCA CCAATCCCGA 3720 TCGGCTCTTA TTAGCTCCCC GCTCCACAAG ACACCTGTGA TCTGGAAATC TACCACCAAT 3780 CCCGATCGGC TCTTATTAGC TCCCCGCTCC ACAAGACACC TGTGACATCC TCCAGGGCCA 3840 CAGGAGCACG TGCTGACCAG TTTTCCCTTC CAGTTCCTGC ACAAAAAGTG TCCAGAGGGC 3900 TGTTTGCAAA CACTAGTGCA CTTTGTAGCT TTTCACCCTC TGTCCCAGGG AATCTAGGAG 3960 AGATGAGGCC CGTCAGAGTC AAGAGATGTC ATCCCCCCAG GGTCTCCAAG GCATTTCCAC 4020 ACTATTGGTG GCACCTGGAG GACATGCACC AAGGCTTGCC AGAGCCAACA GGAAGTGAGC 4080 CCAGAGCATG GCACATGAGC ATCACCCGCT GATGGTGGCC TGCTGTGCCT GGTGCCAACA 4140 GGGGCATCCC GGCCCGTACC CCTCCAGACA GGAAGCATGG GTTTGCCCAC AGACCTGTCG 4200 GGTGCTCCTG TGAGTGGCCT CCAGATGTCT TTGTGCATAG GCACAAGTGG GCCAGGGCTG 4260 GAGGGAGGTG GGAAACCTCA TCATCCGGTG GGCCCTGCCA ATCTTAACCC AGAACCCTTA 4320 GGTATTCCTG GCAGTAGCCA TGACATTGGA GCACCTTCCT CTCCAGCCAG AGGCTGACCT 4380 GAGGGCCACT GTCCTCAGAT GACACCACCC AGGAGCACCC TAGGTGAGGG GTGAGGGCCC 4440 CCTTATGTGA ACCTCTTGCC TCTTCCTTTC TCCCATCAGA GTGGTTGGAT GGAGCCATTG 4500 GCCTCCTTTT CTTCAGCGGG CCCTTCAACC TCTCTGCACC ATGTTGTCTG GCTGAGGAGC 4560 TACTAGAAAA GCTGAGTGGA GTCTCCTTTC CAACAGGATG ATGCATTTGC TCAATTCTCA 4620 GGGCTGGAAT GAGCCGGCTG GTCCCCCAGA AAGCTGGAGT GGGGTACAGA GTTCAGTTTT 4680 CCTCTCTGTT TACAGCTCCT TGACAGTCCC ACGCCCATCT GGAGTGGGAG CTGGGAGTTA 4740 GTGTTGGAGA AGAAACAACA AAAGCCAATT AGAACCACTA TTTTTAAAAA GTGCTTACTG 4800

TGCACAGATA CTCTTCAAGC ACTGGACGTG GATTCTCTCT CTAGCCCTCA GCACCCCTGC 4860

GGTAGGAGTG CCGCCTCTAC CCACTTGTGA TGGGGTACAG AGGCACTTGC TCTTCTGCAT 4920

GGTGTTCAAT AGGCTGGGAG TTTTATTTAT CTCTTCAAAC TTTGTACAAG AGCTCATGGC 4980

TTGTCTTGGG CTTTCGTCAT TAAACCAAAG GAAATGGAAG CCATTCCCCT GTTGCTCTCC 5040

TTAGTCTTGG TCATCAGAAC CTCACTTGGT ACCATATAGA TCAAAAGCTT TGTAACCACA 5100

GGAAAAAATA AACTCTTCCA TCCCTTAAAG AATAGAATAG TTTGTCCCTC TCATGGGAAT 5160

TGGGCTGTAT GTATATTGTT CTTCCTCCTT AGAATTTAGA GATACAAGAG TTCTACTTAG 5220

AACTTTTCAT GGACACAATT TCCACAACCT TTCAGATGCT GATGTAGAGC TATTGGGAAA 5280

10 GAACTTCCAA ACTCAGGAAG TTTGCAGAGA GCAGACAGCT AGAGATAACT CGGGACCCAG 5340

AGTTGGTCGA CAGATGTTAG ATGTATCCTA GCTTTTAGCC ATAAACCACT CAAAGATTCA 5400

GCCCCCAGAT CCCACAGTCA GAACTGAATC TGCGTTGTTG GGAAGCCAGC AGTGGCCTTG 5460

GGAAGGAAGC CATGGCTGTG GTTCAGAGAG GGTGGGCTGG CAAGCCACTT CCGGGGAAAA 5520

CTCCTTCCGC CCCAGGTTTC TTCTTCTCTT AAGGAGAGAT TGTTCTCACC AACCCGCTGC 5580

15 GTTCATGCTG CCTTCAAAGC TAGATCATGT TTGCCTTGCT TAGAGAATTA CTGCAAATCA 5640

GCCCCAGTGC TTGGCGATGC ATTTACAGAT TTCTAGGCCC TCAGGGTTTT GTAGAGTGTG 5700

AGCCCTGGTG GGCAGGGTTG GGGGGTCTGT CTTCTGCTGG ATGCTGCTTG TAATCCATTT 5760 GGTGTACAGA ATCAACAATA AATAATATAC ATGTAT

20 Seq ID NO: 286 Protein sequence: Protein Accession ft: NP_570843.1

1 11 21 31 41 51

₀r M IPLKHYLLLL V IGCQAWGAGL A IYHGCPSECT C ISRASQVECT G IARIVAVPTP L 1PWNAMSLQI 60

LNTHITELNE SPFLNISALI ALRIEKNELS RITPGAFRNL GSLRYLSLAN NKLQVLPIGL 120

FQGLDSLESL LLSSNQLLQI QPAHFSQCSN LKELQLHGNH LEYIPDGAFD HLVGLTKLNL 180

GKNSLTHISP RVFQHLGNLQ VLRLYENRLT DIPMGTFDGL VNLQELALQQ NQIGLLSPGL 240

FHNNHNLQRL YLSNNHISQL PPSIFMQLPQ LNRLTLFGNS LKELSLGIFG PMPNLRELWL 300

30 YDNHISSLPD NVFSNLRQLQ VLILSRNQIS FISPGAFNGL TELRELSLHT NALQDLDGNV 360

FRMLANLQNI SLQNNRLRQL PGNIFANVNG LMAIQLQNNQ LENLPLGIFD HLGKLCELRL 420

YDNPWRCDSD ILPLRNWLLL NQPRLGTDTV PVCFSPANVR GQSLIIINVN VAVPSVHVPE 480

VPSYPETPWY PDTPSYPDTT SVSSTTELTS PVEDYTDLTT IQVTDDRSVW GMTQAQSGLA 540 IAAIVIGIVA LACSLAACVG CCCCKKRSQA VLMQMKAPNE C

35

Seq ID NO: 287 DNA sequence Nucleic Acid Accession ft: NM 02362 Coding sequence: 1..954

40 1 11 21 31 41 51

I I I I I I

ATGTCTTCTG AGCAGAAGAG TCAGCACTGC AAGCCTGAGG AAGGCGTTGA GGCCCAAGAA 60

GAGGCGCTGG GCCTGGTGGG TGCACAGGCT CCTACTACTG AGGAGCAGGA GGCTGCTGTC 120

TCCTCCTCCT CTCCTCTGGT CCCTGGCACC CTGGAGGAAG TGCCTGCTGC TGAGTCAGCA 180

45 GGTCCTCCCC AGAGTCCTCA GGGAGCCTCT GCCTTACCCA CTACCATCAG CTTCACTTGC 240

TGGAGGCAAC CCAATGAGGG TTCCAGCAGC CAAGAAGAGG AGGGGCCAAG CACCTCGCCT 300

GACGCAGAGT CCTTGTTCCG AGAAGCACTC AGTAACAAGG TGGATGAGTT GGCTCATTTT 360

CTGCTCCGCA AGTATCGAGC CAAGGAGCTG GTCACAAAGG CAGAAATGCT GGAGAGAGTC 420

ATCAAAAATT ACAAGCGCTG CTTTCCTGTG ATCTTCGGCA AAGCCTCCGA GTCCCTGAAG 480

50 ATGATCTTTG GCATTGACGT GAAGGAAGTG GACCCCGCCA GCAACACCTA CACCCTTGTC 540

ACCTGCCTGG GCCTTTCCTA TGATGGCCTG CTGGGTAATA ATCAGATCTT TCCCAAGACA 600

GGCCTTCTGA TAATCGTCCT GGGCACAATT GCAATGGAGG GCGACAGCGC CTCTGAGGAG 660

GAAATCTGGG AGGAGCTGGG TGTGATGGGG GTGTATGATG GGAGGGAGCA CACTGTCTAT 720

GGGGAGCCCA GGAAACTGCT CACCCAAGAT TGGGTGCAGG AAAACTACCT GGAGTACCGG 780

55 CAGGTACCCG GCAGTAATCC TGCGCGCTAT GAGTTCCTGT GGGGTCCAAG GGCTCTGGCT 840

GAAACCAGCT ATGTGAAAGT CCTGGAGCAT GTGGTCAGGG TCAATGCAAG AGTTCGCATT 900 GCCTACCCAT CCCTGCGTGA AGCAGCTTTG TTAGAGGAGG AAGAGGGAGT CTGA

60 Seq ID NO: 288 Protein sequence: Protein Accession ft: NP 002353.1

1 11 21 31 41 51

_Λ- I I I I I I

DJ MSSEQKSQHC KPEEGVEAQE EALGLVGAQA PTTEEQEAAV SSSSPLVPGT LEEVPAAESA 60

GPPQSPQGAS ALPTTISFTC WRQPNEGSSS QEEEGPSTSP DAESLFREAL SNKVDELAHF 120

LLRKYRAKEL VTKAEMLERV IKNYKRCFPV IFGKASESLK MIFGIDVKEV DPASNTYTLV 180

TCLGLSYDGL LGNNQIFPKT GLLIIVLGTI AMEGDSASEE EIWEELGVMG VYDGREHTVY 240

GEPRKLLTQD WVQENYLEYR QVPGSNPARY EFLWGPRALA ETSYVKVLEH WRVNARVRI 300

70 AYPSLREAAL LEEEEGV

Seq ID NO: 289 DNA sequence Nucleic Acid Accession ft: NM_002362 Coding sequence: 46..1344

75

1 . 11 21 31 41 51

C IGGCGGCCGC GICCCTGGTTG GIGTCCCCACT GICTCTCGGGG GICGCCATGGA CIGAGGCCGTG 60

80 GGCGACCTGA AGCAGGCGCT TCCCTGTGTG GCCGAGTCGC CAACGGTCCA CGTGGAGGTG 120

CATCAGCGCG GCAGCAGCAC TGCAAAGAAA GAAGACATAA ACCTGAGTGT TAGAAAGCTA 180

CTCAACAGAC ATAATATTGT GTTTGGTGAT TACACATGGA CTGAGTTTGA TGAACCTTTT 240

TTGACCAGAA ATGTGCAGTC TGTGTCTATT ATTGACACAG AATTAAAGGT TAAAGACTCA 300

CAGCCCATCG ATTTGAGTGC ATGCACTGTT GCACTTCACA TTTTCCAGCT GAATGAAGAT 360

85 GGCCCCAGCA GTGAAAATCT GGAGGAAGAG ACAGAAAACA TAATTGCAGC AAATCACTGG 420

GTTCTACCTG CAGCTGAATT CCATGGGCTT TGGGACAGCT TGGTATACGA TGTGGAAGTC 480

AAATCCCATC TCCTCGATTA TGTGATGACA ACTTTACTGT TTTCAGACAA GAACGTCAAC 540 AGCAACCTCA TCACCTGGAA CCGGGTGGTG CTGCTCCACG GTCCTCCTGG CACTGGAAAA 600

ACATCCCTGT GTAAAGCGTT AGCCCAGAAA TTGACAATTA GACTTTCAAG CAGGTACCGA 660

TATGGCCAAT TAATTGAAAT AAACAGCCAC AGCCTCTTTT CTAAGTGGTT TTCGGAAAGT 720

GGCAAGCTGG TAACCAAGAT GTTTCAGAAG ATTCAGGATT TGATTGATGA TAAAGACGCC 780

CTGGTGTTCG TGCTGATTGA TGAGGTGGAG AGTCTCACAG CCGCCCGAAA TGCCTGCAGG 840

GCGGGCACCG AGCCATCAGA TGCCATCCGC GTGGTCAATG CTGTCTTGAC CCAAATTGAT 900

CAGATTAAAA GGCATTCCAA TGTTGTGATT CTGACCACTT CTAACATCAC CGAGAAGATC 960

GACGTGGCCT TCGTGGACAG GGCTGACATC AAGCAGTACA TTGGGCCACC CTCTGCAGCA 1020

GCCATCTTCA AAATCTACCT CTCTTGTTTG GAAGAACTGA TGAAGTGTCA GATCATATAC 1080

CCTCGCCAGC AGCTGCTGAC CCTCCGAGAG CTAGAGATGA TTGGCTTCAT TGAAAACAAC 1140

GTGTCAAAAT TGAGCCTTCT TTTGAATGAC ATTTCAAGGA AGAGCGAGGG CCTCAGCGGC 1200

CGGGTCCTGA GAAAACTCCC CTTTCTGGCT CATGCGCTGT ATGTCCAGGC CCCCACCGTC 1260

ACCATAGAGG GGTTCCTCCA GGCCCTGTCT CTGGCAGTGG ACAAGCAGTT TGAAGAGAGA 1320

AAGAAGCTTG CAGCTTACAT CTGATCCTGG GCTTCCCCAT CTGGTGCTTT TCCCATGGAG 1380

AACACACAAC CAGTAAGTGA GGTTGCCCCA CACAGCCGTC TCCCAGGGAA TCCCTTCTGC 1440

AAACCAAACG TTACTTAGAC TGCAAGCTAG AAAGCCACCA AGGCCAGGCT TTGTTAAAAG 1500

AAGTGTATTC TATTTATGTT GTTTTAAAAT GCATACTGAG AGACAAACAT CTTGTCATTT 1560

TCACTGTTTG TAAAAGATAA TTCAGATTGT TTGTCTCCTT GTGAAGAACC ATCGAAACCT 1620

GTTTGTTCCC AGCCCACCCC CAGTGGATGG GATGCATAAT GCCAGCAAGT TTTGTTTAAC 1680

AGCAAAAAAG GAAGATTAAT GCAGGTGTTA TAGAAGCCAG AAGAGAAACT GTGTCACCCT 1740

AAAGAAGCAT ATAATCATAG CATTAAAAAT GCACACATTA CTCCAGGTGG AAGGTGGCAA 1800

TTGCTTTCTG ATATCAGCTC GTTTGATTTA GTGCAAAAAT GTTTTCAAGA CTATTTAATG 1860

GATGTAAAAA AGCCTATTTC TACATTATAC CAACTGAGAA AAAAATGGTC GGTAAAGTGT 1920

TCTTTCATAA TAAATAATCA AGACATGGTC CCATTTGCAG GAAAAGTGCA GACTCTGAGT 1980

GTTCCAGGGA AACACATGCT GGACATCCCT TGTAACCCGG TATGGGCGCC CCTGCATTGC 2040

TGGGATGTTT CTGCCCACGG TTTTGTTTGT GCAATAACGT TATCACATTT CTAATGAGGA 2100

TTCACATTAA TATAATATAA AATAAATAGG TCAGTTACTG GTCTCTTTCT GCCGAATGTT 2160 ATGTTTTGCT TTTATCTCAC AGTAAAATAA ATATAATTAA AAA

Seq ID NO: 290 Protein sequence: Protein Accession ft: NP 004228

11 41 51

MDEAVGDLKQ ALPCVAESPT VHVEVHQRGS STAKKEDINL SVRKLLNRHN IVFGDYTWTE 60

FDEPFLTRNV QSVSIIDTEL KVKDSQPIDL SACTVALHIF QLNEDGPSSE NLEEETENII 120

AANHWVLPAA EFHGLWDSLV YDVEVKSHLL DYVMTTLLFS DKNVNSNLIT WNRWLLHGP 180

PGTGKTSLCK ALAQKLTIRL SSRYRYGQLI EINSHSLFSK WFSESGKLVT KMFQKIQDLI 240

DDKDALVFVL IDEVESLTAA RNACRAGTEP SDAIRWNAV LTQIDQIKRH SNWILTTSN 300

ITEKIDVAFV DRADIKQYIG PPSAAAIFKI YLSCLEELMK CQIIYPRQQL LTLRELEMIG 360

FIENNVSKLS LLLNDISRKS EGLSGRVLRK LPFLAHALYV QAPTVTIEGF LQALSLAVDK 420

QFEERKKLAA Yl

Seq ID NO: 291 DNA sequence Nucleic Acid Accession ft : NM_002658.1

Coding sequence : 77-1372

11 21 31 41 51

I I I I I

GTCCCCGCAG CGCCGTCGCG CCCTCCTGCC GCAGGCCACC GAGGCCGCCG CCGTCTAGCG 60 CCCCGACCTC GCCACCATGA GAGCCCTGCT GGCGCGCCTG CTTCTCTGCG TCCTGGTCGT 120 GAGCGACTCC AAAGGCAGCA ATGAACTTCA TCAAGTTCCA TCGAACTGTG ACTGTCTAAA 180 TGGAGGAACA TGTGTGTCCA ACAAGTACTT CTCCAACATT CACTGGTGCA ACTGCCCAAA 240 GAAATTCGGA GGGCAGCACT GTGAAATAGA TAAGTCAAAA ACCTGCTATG AGGGGAATGG 300 TCACTTTTAC CGAGGAAAGG CCAGCACTGA CACCATGGGC CGGCCCTGCC TGCCCTGGAA 360 CTCTGCCACT GTCCTTCAGC AAACGTACCA TGCCCACAGA TCTGATGCTC TTCAGCTGGG 420 CCTGGGGAAA CATAATTACT GCAGGAACCC AGACAACCGG AGGCGACCCT GGTGCTATGT 480 GCAGGTGGGC CTAAAGCCGC TTGTCCAAGA GTGCATGGTG CATGACTGCG CAGATGGAAA 540 AAAGCCCTCC TCTCCTCCAG AAGAATTAAA ATTTCAGTGT GGCCAAAAGA CTCTGAGGCC 600 CCGCTTTAAG ATTATTGGGG GAGAATTCAC CACCATCGAG AACCAGCCCT GGTTTGCGGC 660 CATCTACAGG AGGCACCGGG GGGGCTCTGT CACCTACGTG TGTGGAGGCA GCCTCATCAG 720 CCCTTGCTGG GTGATCAGCG CCACACACTG CTTCATTGAT TACCCAAAGA AGGAGGACTA 780 CATCGTCTAC CTGGGTCGCT CAAGGCTTAA CTCCAACACG CAAGGGGAGA TGAAGTTTGA 840 GGTGGAAAAC CTCATCCTAC ACAAGGACTA CAGCGCTGAC ACGCTTGCTC ACCACAACGA 900 CATTGCCTTG CTGAAGATCC GTTCCAAGGA GGGCAGGTGT GCGCAGCCAT CCCGGACTAT 960 ACAGACCATC TGCCTGCCCT CGATGTATAA CGATCCCCAG TTTGGCACAA GCTGTGAGAT 1020 CACTGGCTTT GGAAAAGAGA ATTCTACCGA CTATCTCTAT CCGGAGCAGC TGAAAATGAC 1080 TGTTGTGAAG CTGATTTCCC ACCGGGAGTG TCAGCAGCCC CACTACTACG GCTCTGAAGT 1140 CACCAGCAAA ATGCTATGTG CTGCTGACCC CCAATGGAAA ACAGATTCCT GCCAGGGAGA 1200 CTCAGGGGGA CCCCTCGTCT GTTCCCTCCA AGGCCGCATG ACTTTGACTG GAATTGTGAG 1260 CTGGGGCCGT GGATGTGCCC TGAAGGACAA GCCAGGCGTC TACACGAGAG TCTCACACTT 1320 CTTACCCTGG ATCCGCAGTC ACACCAAGGA AGAGAATGGC CTGGCCCTCT GAGGGTCCCC 1380 AGGGAGGAAA CGGGCACCAC CCGCTTTCTT GCTGGTTGTC ATTTTTGCAG TAGAGTCATC 1440 TCCATCAGCT GTAAGAAGAG ACTGGGAAGA TAGGCTCTGC ACAGATGGAT TTGCCTGTGG 1500 CACCACCAGG GTGAACGACA ATAGCTTTAC CCTCACGGAT AGGCCTGGGT GCTGGCTGCC 1560 CAGACCCTCT GGCCAGGATG GAGGGGTGGT CCTGACTCAA CATGTTACTG ACCAGCAACT 1620 TGTCTTTTTC TGGACTGAAG CCTGCAGGAG TTAAAAAGGG CAGGGCATCT CCTGTGCATG 1680 GGCTCGAAGG GAGAGCCAGC TCCCCCGACC GGTGGGCATT TGTGAGGCCC ATGGTTGAGA 1740 AATGAATAAT TTCCCAATTA GGAAGTGTAA GCAGCTGAGG TCTCTTGAGG GAGCTTAGCC 1800 AATGTGGGAG CAGCGGTTTG GGGAGCAGAG ACACTAACGA CTTCAGGGCA GGGCTCTGAT 1860 ATTCCATGAA TGTATCAGGA AATATATATG TGTGTGTATG TTTGCACACT TGTTGTGTGG 1920 GCTGTGAGTG TAAGTGTGAG TAAGAGCTGG TGTCTGATTG TTAAGTCTAA ATATTTCCTT 1980 AAACTGTGTG GACTGTGATG CCACACAGAG TGGTCTTTCT GGAGAGGTTA TAGGTCACTC 2040 CTGGGGCCTC TTGGGTCCCC CACGTGACAG TGCCTGGGAA TGTACTTATT CTGCAGCATG 2100 ACCTGTGACC AGCACTGTCT CAGTTTCACT TTCACATAGA TGTCCCTTTC TTGGCCAGTT 2160 ATCCCTTCCT TTTAGCCTAG TTCATCCAAT CCTCACTGGG TGGGGTGAGG ACCACTCCTT 2220 ACACTGAATA TTTATATTTC ACTATTTTTA TTTATATTTT TGTAATTTTA AATAAAAGTG 2280 ATCAATAAAA TGTGATTTTT CTGA

Seq ID NO: 292 Protein sequence: Protein Accession ft :NP_002649.1

1 11 21 31 41 51

M IRALLARLLL CIVLWSDSKG SINELHQVPSN CIDCLNGGTCV SINKYFSNIHW CINCPKKFGGQ 60

HCEIDKSKTC YEGNGHFYRG KASTDTMGRP CLPWNSATVL QQTYHAHRSD ALQLGLGKHN 120

10 YCRNPDNRRR PWCYVQVGLK PLVQECMVHD CADGKKPSSP PEELKFQCGQ KTLRPRFKII 180

GGEFTTIENQ PWFAAIYRRH RGGSVTYVCG GSLISPCWVI SATHCFIDYP KKEDYIVYLG 240

RSRLNSNTQG EMKFEVENLI LHKDYSADTL AHHNDIALLK IRSKEGRCAQ PSRTIQTICL 300

PSMYNDPQFG TSCEITGFGK ENSTDYLYPE QLKMTWKLI SHRECQQPHY YGSEVTTKML 360

CAADPQWKTD SCQGDSGGPL VCSLQGRMTL TGIVSWGRGC ALKDKPGVYT RVSHFLPWIR 420

15 SHTKEENGLA L

Seq ID NO: 293 DNA sequence Nucleic Acid Accession ft: NM_001498 Coding sequence: 93..2006

20

1 11 21 31 41 51

GGCACGAGGC TGAGTGTCCG TCTCGCGCCC GGAAGCGGGC GACCGCCGTC AGCCCGGAGG 60

25 AGGAGGAGGA GGAGGAGGAG GAGGGGGCGG CCATGGGGCT GCTGTCCCAG GGCTCGCCGC 120

TGAGCTGGGA GGAAACCAAG CGCCATGCCG ACCACGTGCG GCGGCACGGG ATCCTCCAGT 180

TCCTGCACAT CTACCACGCC GTGAAGGACC GGCACAAGGA CGTTCTCAAG TGGGGCGATG 240

AGGTGGAATA CATGTTGGTA TCTTTTGATC ATGAAAATAA AAAAGTCCGG TTGGTCCTGT 300

CTGGGGAGAA AGTTCTTGAA ACTCTGCAAG AGAAGGGGGA AAGGACAAAC CCAAACCATC 360

30 CTACCCTTTG GAGACCAGAG TATGGGAGTT ACATGATTGA AGGGACACCA GGACAGCCCT 420

ACGGAGGAAC AATGTCCGAG TTCAATACAG TTGAGGCCAA CATGCGAAAA CGCCGGAAGG 480

AGGCTACTTC TATATTAGAA GAAAATCAGG CTCTTTGCAC AATAACTTCA TTTCCCAGAT 540

TAGGCTGTCC TGGGTTCACA CTGCCCGAGG TCAAACCCAA CCCAGTGGAA GGAGGAGCTT 600

CCAAGTCCCT CTTCTTTCCA GATGAAGCAA TAAACAAGCA CCCTCGCTTC AGTACCTTAA 660

35 CAAGAAATAT CCGACATAGG AGAGGAGAAA AGGTTGTCAT CAATGTACCA ATATTTAAGG 720

ACAAGAATAC ACCATCTCCA TTTATAGAAA CATTTACTGA GGATGATGAA GCTTCAAGGG 780

CTTCTAAGCC GGATCATATT TACATGGATG CCATGGGATT TGGAATGGGC AATTGCTGTC 840

TCCAGGTGAC ATTCCAAGCC TGCAGTATAT CTGAGGCCAG ATACCTTTAT GATCAGTTGG 900

CTACTATCTG TCCAATTGTT ATGGCTTTGA GTGCTGCATC TCCCTTTTAC CGAGGCTATG 960

40 TGTCAGACAT TGATTGTCGC TGGGGAGTGA TTTCTGCATC TGTAGATGAT AGAACTCGGG 1020

AGGAGCGAGG ACTGGAGCCA TTGAAGAACA ATAACTATAG GATCAGTAAA TCCCGATATG 1080

ACTCAATAGA CAGCTATTTA TCTAAGTGTG GTGAGAAATA TAATGACATC GACTTGACGA 1140

TAGATAAAGA GATCTACGAA CAGCTGTTGC AGGAAGGCAT TGATCATCTC CTGGCCCAGC 1200

ATGTTGCTCA TCTCTTTATT AGAGACCCAC TGACACTGTT TGAAGAGAAA ATACACCTGG 1260

45 ATGATGCTAA TGAGTCTGAC CATTTTGAGA ATATTCAGTC CACAAATTGG CAGACAATGA 1320

GATTTAAGCC CCCTCCTCCA AACTCAGACA TTGGATGGAG AGTAGAATTT CGACCCATGG 1380

AGGTGCAATT AACAGACTTT GAGAACTCTG CCTATGTGGT GTTTGTGGTA CTGCTCACCA 1440

GAGTGATCCT TTCCTACAAA TTGGATTTTC TCATTCCACT GTCAAAGGTT GATGAGAACA 1500

TGAAGGTAGC ACAGAAAAGA GATGCTGTCT TGCAGGGAAT GTTTTATTTC AGGAAAGATA 1560

50 TTTGCAAAGG TGGCAATGCA GTGGTGGATG GTTGTGGCAA GGCCCAGAAC AGCACGGAGC 1620

TCGCTGCAGA GGAGTACACC CTCATGAGCA TAGACACCAT CATCAATGGG AAGGAAGGTG 1680

TGTTTCCTGG ACTGATCCCA ATTCTGAACT CTTACCTTGA AAACATGGAA GTGGATGTGG 1740

ACACCAGATG TAGTATTCTG AACTACCTAA AGCTAATTAA GAAGAGAGCA TCTGGAGAAC 1800

TAATGACAGT TGCCAGATGG ATGAGGGAGT TTATCGCAAA CCATCCTGAC TACAAGCAAG 1860

55 ACAGTGTCAT AACTGATGAA ATGAATTATA GCCTTATTTT GAAGTGTAAC CAAATTGCAA 1920

ATGAATTATG TGAATGCCCA GAGTTACTTG GATCAGCATT TAGGAAAGTA AAATATAGTG 1980

GAAGTAAAAC TGACTCATCC AACTAGACAT TCTACAGAAA GAAAAATGCA TTATTGACGA 2040

ACTGGCTACA GTACCATGCC TCTCAGCCCG TGTGTATAAT ATGAAGACCA AATGATAGAA 2100

CTGTACTGTT TTCTGGGCCA GTGAGCCAGA AATTGATTAA GGCTTTCTTT GGTAGGTAAA 2160

60 TCTAGAGTTT ATACAGTGTA CATGTACATA GTAAAGTATT TTTGATTAAC AATGTATTTT 2220

AATAACATAT CTAAAGTCAT CATGAACTGG CTTGTACATT TTTAAATTCT TACTCTGGAG 2280

CAACCTACTG TCTAAGCAGT TTTGTAAATG TACTGGTAAT TGTACAATAC TTGCATTCCA 2340

GAGTTAAAAT GTTTACTGTA AATTTTTGTT CTTTTAAAGA CTACCTGGGA CCTGATTTAT 2400

TGAAATTTTT CTCTTTAAAA ACATTTTCTC TCGTTAATTT TCCTTTGTCA TTTCCTTTGT 2460

65 TGTCTACATT AAATCACTTG AATCCATTGA AAGTGCTTCA AGGGTAATCT TGGGTTTCTA 2520

GCACCTTATC TATGATGTTT CTTTTGCAAT TGGAATAATC ACTTGGTCAC CTTGCCCCAA 2580 GCTTTCCCCT CTGAATAAAT ACCCATTGAA CTCTGAAAAA AAAAAAAAAA AAAA

70 Seq ID NO: 294 Protein sequence: Protein Accession ft: NP 001489

_,_ 1 11 21 31 41 51

75 i i i i i i

MGLLSQGSPL SWEETKRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE VEYMLVSFDH 60

ENKKVRLVLS GEKVLETLQE KGERTNPNHP TLWRPEYGSY MIEGTPGQPY GGTMSEFNTV 120

EANMRKRRKE ATSILEENQA LCTITSPPRL GCPGFTLPEV KPNPVEGGAS KSLFFPDEAI 180

- NKHPRFSTLT RNIRHRRGEK WINVPIFKD KNTPSPFIET FTEDDEASRA SKPDHIYMDA 240

80 MGFGMGNCCL QVTFQACSIS EARYLYDQLA TICPIVMALS AASPFYRGYV SDIDCRWGVI 300

SASVDDRTRE ERGLEPLKNN NYRISKSRYD SIDSYLSKCG EKYNDIDLTI DKEIYEQLLQ 360

EGIDHLLAQH VAHLFIRDPL TLFEEKIHLD DANESDHFEN IQSTNWQTMR FKPPPPNSDI 420

GWRVEFRPME VQLTDFENSA YWFWLLTR VILSYKLDFL IPLSKVDENM KVAQKRDAVL 480

__ QGMFYFRKDI CKGGNAWDG CGKAQNSTEL AAEEYTLMSI DTIINGKEGV FPGLIPILNS 540

85 YLENMEVDVD TRCSILNYLK LIKKRASGEL MTVARWMREF IANHPDYKQD SVITDEMNYS 600

LILKCNQIAN ELCECPELLG SAFRKVKYSG SKTDSSN Seq ID NO: 295 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 247-816

1 11 21 31 41 51

I I I I I I

AGTGTTCGGC TGGGGCAGGC ACGCTGTGGC TGGCTACTTC CCTTCCTCCC ATCCCCCTTG 60

GGCCAAACGG GATCGGTGCT TCTGGTGAGA CGCCTCCCCA TGCACATCAC TCCCAGGTGC 120

CCTAGGGGGC ACATTTCCCA CAACTCCCAG AGGGCAGGTT TCTAGAAAGT GCCACCAGTG 180

GGGAGGCGCC ACAACTTCAC TGCCATTTTG TGAGGTGCCG CCGTCTCTCC TCCAGCAAGG 240

GAAACAATGA CCGATAAAAC AGAGAAGGTG GCTGTAGATC CTGAAACTGT GTTTAAACGT 300

CCCAGGGAAT GTGACAGTCC TTCGTATCAG AAAAGGCAGA GGATGGCCCT GTTGGCAAGG 360

AAACAAGGAG CAGGAGACAG CCTTATTGCA GGCTCTGCCA TGTCCAAAGA AAAGAAGCTT 420

ATGACAGGAC ATGCTATTCC ACCCAGCCAA TTGGATTCTC AGATTGATGA CTTCACTGGT 480

TTCAGCAAAG ATAGGATGAT GCAGAAACCT GGTAGCAATG CACCTGTGGG AGGAAACGTT 540

ACCAGCAGTT TCTCTGGAGA TGACCTAGAA TGCAGAGAAA CAGCCTCCTC TCCCAAAAGC 600

CAACGAGAAA TTAATGCTGA TATAAAACGT AAATTAGTGA AGGAACTCCG ATGCGTTGGA 660

CAAAAATATG AAAAAATCTT CGAAATGCTT GAAGGAGTGC AAGGACCTAC TGCAGTCAGG 720

AAGCGATTTT TTGAATCCAT CATCAAGGAA GCAGCAAGAT GTATGAGACG AGACTTTGTT 780

AAGCACCTTA AGAAGAAACT GAAACGTATG ATTTGAGAAT ACTTGTCCCT GGAGGATTAT 840

CACACCCCAA ATGCATAATC TCGTTAATGA TTGAGGAGAG AAAAGGATCA GATTGCTGTT 900

TTCTACAATG GAGCAGGATA TTGCTGAAGT CTCCTGGCAT ATGTTACCGA ATCAAATAGC 960

CTTCCAGAGG CTAAGAAATT TCTGTTAGTA AAAGATGTTC TTTTTCCCAA AGCATTTTAT 1020

TTGAAAGGAT AACTTGTGTT TTGGTTATTT TGTATTCCCA CCTGTGCTGG TAGATATTAT 1080 TAACCCATTA GGTAAATACT ATTACAGTCG TGGTTTCTGC A

Seq ID NO: 296 Protein sequence: Protein Accession ft: Eos sequence

1 11 21 31 41 51

M ITDKTEKVAV DIPETVFKRPR EICDSPSYQKR QIRMALLARKQ GIAGDSLIAGS AIMSKEKKLMT 60

GHAIPPSQLD SQIDDFTGFS KDRMMQKPGS NAPVGGNVTS SFSGDDLECR ETASSPKSQR 120

EINADIKRKL VKELRCVGQK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH 180 LKKKLKRMI

Seq ID NO: 297 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 247-815

1 11 21 31 41 51

I I I I I I

AGTGTTCGGC TGGGGCAGGC ACGCTGTGGC TGGCTACTTC CCTTCCTCCC ATCCCCCTTG 60

GGCCAAACGG GATCGGTGCT TCTGGTGAGA CGCCTCCCCA TGCACATCAC TCCCAGGTGC 120

CCTAGGGGGC ACATTTCCCA CAACTCCCAG AGGGCAGGTT TCTAGAAAGT GCCACCAGTG 180

GGGAGGCGCC ACAACTTCAC TGCCATTTTG TGAGGTGCCG CCGTCTCTCC TCCAGCAAGG 240

GAAACAATGA CCGATAAAAC AGAGAAGGTG GCTGTAGATC CTGAAACTGT GTTTAAACGT 300

CCCAGGGAAT GTGACAGTCC TTCGTATCAG AAAAGGCAGA GGATGGCCCT GTTGGCAAGG 360

AAACAAGGAG CAGGAGACAG CCTTATTGCA GGCTCTGCCA TGTCCAAAGA AAAGAAGCTT 420

ATGACAGGAC ATGCTATTCC ACCCAGCCAA TTGGATTCTC AGATTGATGA CTTCACTGGT 480

TTCAGCAAAG ATAGGATGAT GCAGAAACCT GGTAGCAATG CACCTGTGGG AGGAAACGTT 540

ACCAGCAGTT TCTCTGGAGA TGACCTAGAA TGCAGAGAAA CAGCCTCCTC TCCCAAAAGC 600

CAACAAGAAA TTAATGCTGA TATAAAACGT AAATTAGTGA AGGAACTCCG ATGCGTTGGA 660

CAAAAATATG AAAAAATCTT CGAAATGCTT GAAGGAGTGC AAGGACCTAC TGCAGTCAGG 720

AAACGATTTT TTGAATCCAT CATCAAGGAA GCAGCAAGAT GTATGAGACG AGACTTTGTT 780

AAGCACCTTA AGAAGAAACT GAAACGTATG ATTTGAGAAT ACTTGTCCCT GGAGGATTAT 840

CACACCCCAA ATGCATAATC TCATTAATGA TTGAGGAGAG AAAAGGATCA GATTGCTGTT 900

TTCTACAATG GAGCAGGATA TTGCTGAAGT CTCCTGGCAT ATGTTACCGA ATCAACTGGC 960

CTTCCAGAGG CTAAGAAATT TCTGTTAGTA AAAGATGTTC TTTTTCCCAA AGCGTTTTAT 1020

TTGAAAGGAT AACTTGTGTT TTGGTTATTT TGTATTCCCA CCTGTGCTGG TAGATATTAT 1080 TAACCCATTA GGTAAATACT ATTACAGTCG TGGTTTCTGC A

Seq ID NO: 298 Protein sequence: Protein Accession ft: Eos sequence

1 11 21 31 41 51

M ITDKTEKVAV DIPETVFKRPR EICDSPSYQKR QIRMALLARKQ GIAGDSLIAGS AIMSKEKKLMT 60

GHAIPPSQLD SQIDDFTGFS KDRMMQKPGS NAPVGGNVTS SFSGDDLECR ETASSPKSQQ 120

EINADIKRKL VKELRCVGQK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH 180 LKKKLKRMI

Seq ID NO: 299 DNA sequence Nucleic Acid Accession ft: Eos sequence Coding sequence: 247-815

1 11 21 31 41 51

I I I I I I

AGTGTTCGGC TGGGGCAGGC ACGCTGTGGC TGGCTACTTC CCTTCCTCCC ATCCCCCTTG 60

GGCCAAACGG GATCGGTGCT TCTGGTGAGA CGCCTCCCCA TGCACATCAC TCCCAGGTGC 120

CCTAGGGGGC ACATTTCCCA CAACTCCCAG AGGGCAGGTT TCTAGAAAGT GCCACCAGTG 180

GGGAGGCGCC ACAACTTCAC TGCCATTTTG TGAGGTGCCG CCGTCTCTCC TCCAGCAAGG 240

GAAACAATGA CCGATAAAAC AGAGAAGGTG GCTGTAGATC CTGAAACTGT GTTTAAACGT 300

CCCAGGGAAT GTGACAGTCC TTCGTATCAG AAAAGGCAGA GGATGGCCCT GTTGGCAAGG 360

AAACAAGGAG CAGGAGACAG CCTTATTGCA GGCTCTGCCA TGTCCAAAGC AAAGAGCTTA 420

TGACAGGACA TGCTATTCCA CCCAGCCAAT TGGATTCTCA GATTGATGAC TTCACTGGTT 480 TCAGCAAAGA TAGGATGATG CAGAAACCTG GTAGCAATGC ACCTGTGGGA GGAAACGTTA 540

CCAGCAGTTT CTCTGGAGAT GACCTAGAAT GCAGAGAAAC AGCCTCCTCT CCCAAAAGCC 600

AACAAGAAAT TAATGCTGAT ATAAAACGTA AATTAGTGAA GGAACTCCGA TGCGTTGGAC 660

AAAAATATGA AAAAATCTTC GAAATGCTTG AAGGAGTGCA AGGACCTACT GCAGTCAGGA 720

AACGATTTTT TGAATCCATC ATCAAGGAAG CAGCAAGATG TATGAGACGA GACTTTGTTA 780

AGCACCTTAA GAAGAAACTG AAACGTATGA TTTGAGAATA CTTGTCCCTG GAGGATTATC 840

ACACCCCAAA TGCATAATCT CATTAATGAT TGAGGAGAGA AAAGGATCAG ATTGCTGTTT 900

TCTACAATGG AGCAGGATAT TGCTGAAGTC TCCTGGCATA TGTTACCGAA TCAACTGGCC 960

TTCCAGAGGC TAAGAAATTT CTGTTAGTAA AAGATGTTCT TTTTCCCAAA GCGTTTTATT 1020

TGAAAGGATA ACTTGTGTTT TGGTTATTTT GTATTCCCAC CTGTGCTGGT AGATATTATT 1080 AACCCATTAG GTAAATACTA TTACAGTCGT GGTTTCTGCA

Seq ID NO: 300 Protein sequence: Protein Accession ft: Eos sequence

1 11 21 31 41 51

I I I I I I

MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS AMSKAKKLMT 60

GHAIPPSQLD SQIDDFTGFS KDRMMQKPGS NAPVGGNVTS SFSGDDLECR ETASSPKSQQ 120

EINADIKRKL VKELRCVGQK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH 180 LKKKLKRMI

Seq ID NO : 301 DNA sequence Nucleic Acid Accession ft : Eos sequence Coding sequence : 247- 812

1 11 21 31 41 51

I I I I I I

AGTGTTCGGC TGGGGCAGGC ACGCTGTGGC TGGCTACTTC CCTTCCTCCC ATCCCCCTTG 60

GGCCAAACGG GATCGGTGCT TCTGGTGAGA CGCCTCCCCA TGCACATCAC TCCCAGGTGC 120

CCTAGGGGGC ACATTTCCCA CAACTCCCAG AGGGCAGGTT TCTAGAAAGT GCCACCAGTG 180

GGGAGGCGCC ACAACTTCAC TGCCATTTTG TGAGGTGCCG CCGTCTCTCC TCCAGCAAGG 240

GAAACAATGA CCGATAAAAC AGAGAAGGTG GCTGTAGATC CTGAAACTGT GTTTAAACGT 300

CCCAGGGAAT GTGACAGTCC TTCGTATCAG AAAAGGCAGA GGATGGCCCT GTTGGCAAGG 360

AAACAAGGAG CAGGAGACAG CCTTATTGCA GGCTCTGCCA TGTCCAAAGA AAAGAGCTTA 420

TGACAGGACA TGCTATTCCA CCCAGCCAAT TGGATTCTCA GATTGATGAC TTCACTGGTT 480

TCAGCAAAGA TGGGATGATG CAGAAACCTG GTAGCAATGC ACCTGTGGGA GGAAATGTTA 540

CCAGCAATTT CTCTGGAGAT GACCTAGAAT GCAGAGGAAT AGCCTCCTCT CCCAAAAGCC 600

AACAAGAAAT TAATGCTGAT ATAAAATGTC AAGTAGTGAA GGAAATCCGA TGCCTTGGAC 660

AATATGAAAA AATCTTCGAA ATGCTTGAAG GAGTGCAAGG ACCTACTGCA GTCAGGAAAC 720

GATTTTTTGA ATCCATCATC AAGGAAGCAG CAAGATGTAT GAGACGAGAC TTTGTTAAGC 780

ACCTTAAGAA GAAACTGAAA CGTATGATTT GAGAATACTT GTCCCTGGAG GATTATCACA 840

CCCCAAATGC ATAATCTCAT TAATGATTGA GGAGAGAAAA GGATCAGATT GCTGTTTTCT 900

ACAATGGAGC AGGATATTGC TGAAGTCTCC TGGCATATGT TACCGAATCA ACTGGCCTTC 960

CAGAGGCTAA GAAATTTCTG TTAGTAAAAβ ATGTTCTTTT TCCCAAAGCG TTTTATTTGA 1020

AAGGATAACT TGTGTTTTGG TTATTTTGTA TTCCCACCTG TGCTGGTAGA TATTATTAAC 1080 CCATTAGGTA AATACTATTA CAGTCGTGGT TTCTGCA

Seq ID NO: 302 Protein sequence: Protein Accession ft: Eos sequence

1 11 21 31 41 51

I I I I I I

MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS AMSKEKKLMT 60

GHAIPPSQLD SQIDDFTGFS KDGMMQKPGS NAPVGGNVTS NFSGDDLECR GIASSPKSQQ 120

EINADIKCQV VKEIRCLGQY EKIFEMLEGV QGPTAVRKRF FESIIKEAAR CMRRDFVKHL 180 KKKLKRMI

Seq ID NO : 303 DNA sequence Nucleic Acid Accession ft : Eos sequence

Coding sequence : 247-815

1 11 21 31 41 51

I I I I I I

AGTGTTCGGC TGGGACAGGC ACGCTGTGGC TGGCTACTTC CCTTCCTTCC ATCCCCCTTG 60

GGCCAAACAG GATCGGTGCT TCTGGTGAGA CGTCTCCCCA TGCACATCAC TCCCAGATGC 120

CCTAGGGGGC ACATTTCCCA CAACTCCCAG AGGGCAGGTT TCTAGAAAGT GCCACCAGTG 180

GGGAGGCGCC ACAACTTCAC TGCCATTTTG TGAGGTGCCG CCGTCTCTCC TCCAGCAAGG 240

GAAACAATGA CCGATAAAAC AGAGAAGGTG GCTGTAGATC CTGAAACTGT GTTTAAACGT 300

CCCAGGGAAT GTGACAGTCC TTCGTATCAG AAAAGGCAGA GGATGGCCCT GTTGGCAAGG 360

AAACAAGGAG CAGGAGACAG CCTTATTGCA GGCTCTGCCA TGTCCAAAGC AAAGAGCTTA 420

TGACAGGACA TGCTATTCCA CCCAGCCAAT TGGATTCTCA GATTGATGAC TTCACTGGTT 480

TCAGCAAAGA TAGGATGATG CAGAAACCTG GTAGCAATGC ACCTGTGGGA GGAAACGTTA 540

CCAGCAGTTT CTCTGGAGAT GACCTAGAAT GCAGAGAAAC AGCCTCCTCT CCCAAAAGCC 600

AACAAGAAAT TAATGCTGAT ATAAAACGTA AATTAGTGAA GGAACTCCGA TGCGTTGGAC 660

AAAAATATGA AAAAATCTTC GAAATGCTTG AAGGAGTGCA AGGACCTACT GCAGTCAGGA 720

AACGATTTTT TGAATCCATC ATCAAGGAAG CAGCAAGATG TATGAGACGA GACTTTGTTA 780

AGCACCTTAA GAAGAAACTG AAACGTATGA TTTGAGAATA CTTGTCCCTG GAGGATTATC 840

ACACCCCAAA TGCATAATCT CGTTAATGAT TGAGGAGAGA AAAGGATCAG ATTGCTGTTT 900

TCTACAATGG AGCAGGATAT TGCTGAAGTC TCCTGGCATA TGTTACCGAA TCAACTGGCC 960

TTCCAGAGGC TAAGAAATTT CTGTTAGTAA AAGATGTTCT TTTTCCCAAA GCGTTTTATT 1020

TGAAAGGATA ACTTGTGTTT TGGTTATTTT GTATTCCCAC CTGTGCTGGT AGATATTATT 1080 AACCCATTAG GTAAATACTA TTACAGTCGT GGTTTCTGCA

Seq ID NO: 304 Protein sequence: Protein Accession ft: Eos sequence 1 11 21 31 41 51

I I I I I I

MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS AMSKAKKLMT 60

GHAIPPSQLD SQIDDFTGFS KDRMMQKPGS NAPVGGNVTS SFSGDDLECR ETASSPKSQQ 120

5 EINADIKRKL VKELRCVGQK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH 180 LKKKLKRMI

Seq ID NO: 305 DNA sequence _Λ - Nucleic Acid Accession ft: Eos sequence I V Coding sequence: 87-689

1 11 21 31 41 51

I I I I I I

CGTGGAGGCA GCTAGCGCGA GGCTGGGGAG CGCTGAGCCG CGCGTCGTGC CCTGCGCTGC 60

15 CCAGACTAGC GAACAATACA GTCAGGATGG CTAAAGGTGA CCCCAAGAAA CCAAAGGGCA 120

AGATGTCCGC TTATGCCTTC TTTGTGCAGA CATGCAGAGA AGAACATAAG AAGAAAAACC 180

CAGAGGTCCC TGTCAATTTT GCGGAATTTT CCAAGAAGTG CTCTGAGAGG TGGAAGACGA 240

TGTCCGGGAA AGAGAAATCT AAATTTGATG AAATGGCAAA GGCAGATAAA GTGCGCTATG 300

ATCGGGAAAT GAAGGATTAT GGACCAGCTA AGGGAGGCAA GAAGAAGAAG GATCCTAATG 360 0 CTCCCAAAAG GCCACCGTCT GGATTCTTCC TGTTCTGTTC AGAATTCCGC CCCAAGATCA 420

AATCCACAAA CCCCGGCATC TCTATTGGAG ACGTGGCAAA AAAGCTGGGT GAGATGTGGA 480

ATAATTTAAA TGACAGTGAA AAGCAGCCTT ACATCACTAA GGCGGCAAAG CTGAAGGAGA 540

AGTATGAGAA GGATGTTGCT GACTATAAGT CGAAAGGAAA GTTTGATGGT GCAAAGGGTC 600

CTGCTAAAGT TGCCCGGAAA AAGGTGGAAG AGGAAGATGA AGAAGAGGAG GAGGAAGAAG 660 5 AGGAGGAGGA GGAGGAGGAG GATGAATAAA GAAACTGTTT ATCTGTCTCC TTGTGAATAC 720

TTAGAGTAGG GGAGCGCCGT AATTGACACA TCTCTTATTT GAGAAGTGTC TGTTGCCCTC 780

ATTAGGTTTA ATTACAAAAT TTGATCACGA TCATATTGTA GTCTCTCAAA GTGCTCTAGA 840

AATTGTCAGT GGTTTACATG AAGTGGCCAT GGGTGTCTGG AGCACCCTGA AACTGTATCA 900

AAGTTGTACA TATTTCCAAA CATTTTTAAA ATGAAAAGGC ACTCTCGTGT TCTCCTCACT 960 0 CTGTGCACTT TGCTGTTGGT GTGACAAGGC ATTTAAAGAT GTTTCTGGCA TTTTCTTTTT 1020

ATTTGTAAGG TGGTGGTAAC TATGGTTATT GGCTAGAAAT CCTGAGTTTT CAACTGTATA 1080

TATCTATAGT TTGTAAAAAG AACAAAACAA CCGAGACAAA CCCTTGATGC TCCTTGCTCG 1140

GCGTTGAGGC TGTGGGGAAG ATGCCTTTTG GGAGAGGCTG TAGCTCAGGG CGTGCACTGT 1200

GAGGCTGGAC CTGTTGACTC TGCAGGGGGC ATCCATTTAG CTTCAGGTTG TCTTGTTTCT 1260 5 GTATATAGTG ACATAGCATT CTGCTGCCAT CTTAGCTGTG GACAAAGGGG GGTCAGCTGG 1320

CATGAGAATA TTTTTTTTTT TAAGTGCGGT AGTTTTTAAA CTGTTTGTTT TTAAACAAAC 1380

TATAGAACTC TTCATTGTCA GCAAAGCAAA GAGTCACTGC ATCAATGAAA GTTCAAGAAC 1440

CTCCTGTACT TAAACACGAT TCGCAACGTT CTGTTATTTT TTTTGTATGT TTAGAATGCT 1500

GAAATGTTTT TGAAGTTAAA TAAACAGTAT TACATTTTTA AAACTCTTCT CTATTATAAC 1560 0 AGTCAATTTC TGACTCACAG CAGTGAACAA ACCCCCACTC CATTGTATTT GGAGACTGGC 1620

CTCCCTATAA ATGTGGTAGC TTCTTTTATT ACTCAGTGGC CAGCTCACTT AGGGCTGAGA 1680

TGAAGGAGAG GGCTACTTGA AGCTACTGTG TGATTTTGTT TGTGTCTGAG TGGCATTCAG 1740

ATGAAGTCTG GAGGAGTTAG GAGAACGACA TAGGCAAGGT TCAGCAGCCT TCCAAGGTAT 1800

AGGAAGGTGG GTGATTAGGA CTGAGGCTAT CTAGGTTTAA CTTTTGTCCC ACCTCCACCC 1860 5 CCTATTTTGT GGGGCCAAAT GCATTGCTAA ACAGCAATTT CAGAGTGTAT GGTGTGTCAA 1920

AAATTAAGGC CTTATTGTTT TTCTCTTTCA CCCCTACCCC CCGTGCTCCT GGCACATATC 1980

ACATTATTTG TGGTGCCCAA CATTTGGGGT CTTGAGCCTG CTGCTGGTCT CCTGGATGCC 2040

AGTGAGGGTA TGTGGGATGG GGTGGTGGGG TAGGGGACGG TATCCTTTTT TTGCTCCTAC 2100

TTGGAAACAC CAAACACCCC AAGGAAGATG ATAGGCTCCA TCTTGGGCCA CCTGAGCTAT 2160 0 AGGGCAGGCT AATGGAATCA ACCATTTCTG AGCACTAAAT GTATCATGAA AAGTTGAATG 2220

GCCTGCTCAT AAGTTTAGCT CATTCACTGG AAATGTAGAT TGATGTTCAA TGTTAAACTG 2280

GAAGGAGCTT GGTTTGTGTG TCAGTGGTTA TATTAGTGGG TAGTGTAACA TTTTATCCAG 2340

GTTGGGGTGA GGGGAGATGG CCACAGTAGC AAGTGGTGAC ACTAAATACC ATTTTGAAGG 2400

CTGATGTGTA TATACATCAT TACTGTCCGT AGCAATGAAG GATACAGTAC TGTGTTGTGG 2460 5 GTGAGTGTTG CTATTGCCCA GCATTAATAT TTGGGTGTGT ATGTTTGAGG CTATGAAACA 2520

CGCAGGAGTG TTTTTGTGCT ATTAATTTTA AGAGAAAGCA GCTTTTTCTT AAAATTCACT 2580

GTTGAGAAAC TTGCATGTCT GGAGGCGGTG TCCTCTCCGC CCTGTCGGGT CCTGGATGAG 2640

TACGAGTTAT GGTCACGGTC ACAGCCTGAT CTCTTATGTG TTCATAGCCA TTCGCTCTCC 2700

CATCAGAACT GTTTGTCCTG AATGTGTTCC TCTAGTTCTA GAAAATGACC ACTAATTTAA 2760 0 AAAACTCGGT TGTGAGGTTT GCCCAGAGGC ACTTGTTCCA GAATTTCCCC TCCTGCTTCA 2820

GCCATGTCCT TGTCACTTGG CATTCTAAGC TAAAGCTTTA GCTTCCCAAT TCGTGATGTG 2880

CTAGGCCAAG ATTCGGGAGC TGTTGCCAGC CTCGTCAAAT ATGGAAGAGA AACAACCTGC 2940

GGTCAAAAGG GAGTGATTTG TTAAGTGGTG CGCGTCTATC TCATAACTAG ATGTACCAAC 3000

CAGGGAAGGG CCAAGGATGG AAAGGGGTAA CTTTTGTGCT TCCAAAGTAG CTAAGCAGAA 3060 5 GTGGGGGAGC AGTTTAGCCA GATGATCTTT GATTAGGCAA ACATTGAGTT TTAAAGAGGC 3120

TGTCAAGTTG AGGCCACTTG GTCCATTAGC TGGGGCAGCA AGATCACTAC TCAACGTTTT 3180

CACACTGTGG CAAGATTGCT CTTCTAGTGG AATAATGCCC TAGTTTCTCT GAGATGATGT 3240

AAGTGGCATG ATGTTACCTA AGGCTTAGGC TTAGCTTGAT TTCTGGGCCC ACTGTCTGTG 3300

TTCTTAAGAT GCCAACCTGT TGCTTTTTTT TTTTTTTTCC CCCATTTAAA AGGATAGTAC 3360 0 CTACTCCCTC TAACCACCTC ACCCCATTCT TGAATGACAT TTTATCCTTC GGAAAGAACA 3420

AGGCTGTGAT GTAGTGACTA TTGTCTGTGT CTCCTGTGTG TGTCTGTTCT TGTCACAAAT 3480 GTATTTGGGG ACGTTGGATG CATTCATTTT CTGTAATAAA G

Seq ID NO: 306 Protein sequence: 5 Protein Accession ft: NP_005333.1

1 11 21 31 41 51

M IAKGDPKKPK GIKMSAYAFFV QITCREEHKKK NIPEVPVNFAE FISKKCSERWK TIMSGKEKSKF 60 0 DEMAKADKVR YDREMKDYGP AKGGKKKKDP NAPKRPPSGF FLFCSEFRPK IKSTNPGISI 120

GDVAKKLGEM WNNLNDSEKQ PYITKAAKLK EKYEKDVADY KSKGKFDGAK GPAKVARKKV 180

EEEDEEEEEE EEEEEEEEDE

Seq ID NO: 307 DNA sequence 5 Nucleic Acid Accession ft: NM_022342 Coding sequence: 1..2178 1 11 21 31 41 51

I I I I I I

ATGGGTACTA GGAAAAAAGT TCATGCATTT GTCCGTGTCA AACCCACCGA TGACTTTGCT 60 CATGAAATGA TCAGATACGG AGATGACAAA AGAAGCATTG ATATTCACTT AAAAAAAGAC 120

ATTCGGAGAG GAGTTGTCAA TAACCAACAG ACAGACTGGT CGTTTAAGTT GGATGGAGTT 180

TTCACGATG CCTCCCAGGA CTTGGTTTAT GAGACAGTTG CAAAGGATGT GGTTTCTCAG 240

CCCTCGATG GCTATAATGG CACCATCATG TGTTATGGGC AGACGGGAGC TGGCAAGACA 300

ACACCATGA TGGGGGCAAC TGAGAATTAC AAGCACCGGG GGATCCTCCC TCGTGCCCTG 360

AGCAGGTTT TTAGGATGAT CGAAGAACGC CCCACACATG CCATCACTGT GCGTGTTTCC 420

ACTTGGAAA TCTATAATGA GAGCCTGTTT GATCTCCTGT CCACTCTGCC CTATGTTGGA 480

CCTCAGTCA CACCAATGAC CATCGTGGAA AACCCTCAAG GAGTCTTCAT TAAGGGCTTG 540

CAGTTCACC TCACAAGTCA GGAGGAGGAT GCATTCAGCC TCCTTTTTGA GGGTGAGACC 600

ACAGGATTA TAGCCTCCCA CACTATGAAC AAAAACTCTT CCAGATCACA CTGCATTTTC 660

CCATCTACT TAGAGGCCCA TTCCCGGACC TTATCAGAGG AAAAGTACAT CACTTCCAAA 720

TTAACTTGG TGGATCTGGC AGGCTCAGAG AGGCTGGGGA AGTCTGGGTC TGAGGGCCAA 780

TCCTGAAGG AAGCCACCTA CATCAACAAA TCGCTCTCAT TCCTGGAGCA GGCCATCATT 840

CCCTTGGGG ACCAGAAGCG GGACCACATC CCCTTTCGGC AGTGCAAGCT CACCCACGCT 900

TGAAGGACT CGTTAGGGGG AAACTGCAAT ATGGTCCTCG TGACAAACAT CTATGGAGAA 960

CTGCCCAGT TAGAAGAAAC GCTATCTTCA CTGAGATTTG CCAGCAGGAT GAAGCTAGTC 1020

CCACTGAGC CTGCCATCAA TGAAAAGTAT GATGCTGAGA GAATGGTCAA GAACCTGGAG 1080

AGGAACTAG CACTACTCAA GCAGGAGCTG GCTATCCATG ACAGCCTGAC CAACCGCACC 1140

TTGTGACCT ATGACCCCAT GGATGAAATC CAGATTGCTG AGATCAACTC CCAGGTGCGG 1200

GGTACCTGG AGGGGACACT GGACGAGATC GACATAATCA GCCTTAGACA GATCAAGGAG 1260

TGTTCAACC AGTTCCGGGT GGTTCTGAGC CAACAGGAAC AGGAAGTGGA GTCCACTTTG 1320

GCAGGAAGT ACACCCTCAT TGACAGGAAT GACTTTGCAG CCATTTCTGC TATCCAGAAG 1380

CGGGGCTTG TGGATGTTGA TGGCCACCTA GTGGGTGAGC CTGAAGGACA AAACTTTGGA 1440

TCGGAGTCG CCCCTTTCTC TACCAAACCT GGGAAGAAAG CCAAGTCCAA GAAGACATTC 1500

AAGAGCCAC TCAGGCCCGA CACCCCACCC TCCAAACCAG TGGCCTTTGA GGAGTTTAAG 1560

ATGAGCAAG GTAGTGAGAT CAACCGAATT TTCAAAGAAA ACAAATCCAT CTTGAATGAA 1620

GGAGGAAAA GGGCCAGCGA GACCACACAG CACATCAATG CCATCAAGCG GGAGATTGAT 1680

TGACCAAGG AGGCCCTGAA TTTCCAGAAG TCACTACGGG AGAAGCAAGG CAAGTACGAA 1740

ACAAGGGGC TGATGATCAT CGATGAGGAA GAATTCCTGC TGATCCTCAA GCTCAAAGAC 1800

TCAAGAAGC AGTACCGCAG CGAGTACCAG GACCTGCGTG ACCTCAGGGC TGAGATCCAG 1860

ATTGCCAGC ACCTAGTGGA TCAGTGTCGC CACCGCCTGC TCATGGAATT TGACATCTGG 1920

ACAATGAGT CCTTTGTCAT CCCTGAGGAC ATGCAGATGG CACTGAAGCC AGGCGGCAGC 1980

TCCGGCCAG GCATGGTCCC TGTGAACAGG ATTGTGTCTC TGGGAGAAGA TGACCAGGAC 2040

AATTCAGCC AGCTGCAGCA GAGGGTGCTT CCTGAGGGCC CTGATTCCAT CTCCTTCTAC 2100

ATGCCAAAG TCAAGATAGA GCAGAAGCAT AATTACTTGA AAACCATGAT GGGCCTCCAG 2160 AGGCACATA GAAAATAG

Seq ID NO: 308 Protein sequence: Protein Accession ft: NP 071737

11 21 31 41 51

MGTRKKVHAF VRVKPTDDFA HEMIRYGDDK RSIDIHLKKD IRRGWNNQQ TDWSFKLDGV 60 LHDASQDLVY ETVAKDWSQ ALDGYNGTIM CYGQTGAGKT YTMMGATENY KHRGILPRAL 120 QQVFRMIEER PTHAITVRVS YLEIYNESLF DLLSTLPYVG PSVTPMTIVE NPQGVFIKGL 180 SVHLTSQEED AFSLLFEGET NRIIASHTMN KNSSRSHCIF TIYLEAHSRT LSEEKYITSK 240 INLVDLAGSE RLGKSGSEGQ VLKEATYINK SLSFLEQAII ALGDQKRDHI PPRQCKLTHA 300 LKDSLGGNCN MVLVTNIYGE AAQLEETLSS LRFASRMKLV TTEPAINEKY DAERMVKNLE 360 KELALLKQEL AIHDSLTNRT FVTYDPMDEI QIAEINSQVR RYLEGTLDEI DIISLRQIKE 420 VFNQFRWLS QQEQEVESTL RRKYTLIDRN DFAAISAIQK AGLVDVDGHL VGEPEGQNFG 480 LGVAPFSTKP GKKAKSKKTF KEPLRPDTPP SKPVAFEEFK NEQGSEINRI FKENKSILNE 540 RRKRASETTQ HINAIKREID VTKEALNFQK SLREKQGKYE NKGLMIIDEE EFL I KLKD 600 LKKQYRSEYQ DLRDLRAEIQ YCQHLVDQCR HRLLMEFDIW YNESFVIPED MQMALKPGGS 660 IRPGMVPVNR IVSLGEDDQD KFSQLQQRVL PEGPDSISFY NAKVKIEQKH NYLKTMMGLQ 720 QAHRK

Seq ID NO: 309 DNA sequence

Nucleic Acid Accession ft: CAT cluster

11 21 31 41 51

I I I

TTTTTTTTAA TGCCTGCTGT CATGCTCTGT CTACCAGGGT GAATTTCCAA 60

AAATTTCTGC ATAGCAATTT TAGCCAAAAC TATATATGTT CTGGGGAGGA TAGGCATAGG 120 CACATTGAAG ACCAAAGGAA AGAGTGAAGA AGTGTAGTTG GGTCATTGTG AATGGATGTT 180 TAGATTGTCA AGAAAAGTGG GCCAGAGGCC CCACCTCACA CTAGGACGGC AATTGCCTCT 240 CATTAGTATC TCAGGCACCA TGGGTCTTAT TTGGTGTCAT AAGAAACACC CTCAACAAAG 300 TAATGAACCC TCAGCCTCCA GCTTCTCTTC TTCGGGATTC TTCTTAGGGC CTCCTTTTTC 360 CTTTTATGTT TCCAGTACCC TGAATTTCTT ATTCCCATCC CCCATTAAAA TCTGCTTCAA 420 AGAAAAAACA AGAAGGACAC ATTCACTTTA AGATCCAAAT GAATGATAAG AGCTTAAAAC 480 ATTATACTTA TCAGTATTAT TTGCATTTTT ATAGAAACCA AAACCATATT TCAACAAC

Seq ID NO: 310 DNA sequence

Nucleic Acid Accession ft: NM_018622.2

Coding sequence: 1-1140

11 21 31 41 51

ATGGCGTGGC GAGGCTGGGC GCAGAGAGGC TGGGGCTGCG GCCAGGCGTG GGGTGCGTCG 60 GTGGGCGGCC GCAGCTGCGA GGAGCTCACT GCGGTCCTAA CCCCGCCGCA GCTCCTCGGA 120 CGCAGGTTTA ACTTCTTTAT TCAACAAAAA TGCGGATTCA GAAAAGCACC CAGGAAGGTT 180 GAACCTCGAA GATCAGACCC AGGGACAAGT GGTGAAGCAT ACAAGAGAAG TGCTTTGATT 240 CCTCCTGTGG AAGAAACAGT CTTTTATCCT TCTCCCTATC CTATAAGGAG TCTCATAAAA 300 CCTTTATTTT TTACTGTTGG GTTTACAGGC TGTGCATTTG GATCAGCTGC TATTTGGCAA 360 TATGAATCAC TGAAATCCAG GGTCCAGAGT TATTTTGATG GTATAAAAGC TGATTGGTTG 420

GATAGCATAA GACCACAAAA AGAAGGAGAC TTCAGAAAGG AGATTAACAA GTGGTGGAAT 480

AACCTAAGTG ATGGCCAGCG GACTGTGACA GGTATTATAG CTGCAAATGT CCTTGTATTC 540

TGTTTATGGA GAGTACCTTC TCTGCAGCGG ACAATGATCA GATATTTCAC ATCGAATCCA 600

GCCTCAAAGG TCCTTTGTTC TCCAATGTTG CTGTCAACAT TCAGTCACTT CTCCTTATTT 660

CACATGGCAG CAAATATGTA TGTTTTGTGG AGCTTCTCTT CCAGCATAGT GAACATTCTG 720

GGTCAAGAGC AGTTCATGGC AGTGTACCTA TCTGCAGGTG TTATTTCCAA TTTTGTCAGT 780

TACCTGGGTA AAGTTGCCAC AGGAAGATAT GGACCATCAC TTGGTGCATC TGGTGCCATC 840

ATGACAGTCC TCGCAGCTGT CTGCACTAAG ATCCCAGAAG GGAGGCTTGC CATTATTTTC 900

CTTCCGATGT TCACGTTCAC AGCAGGGAAT GCCCTGAAAG CCATTATCGC CATGGATACA 960

GCAGGAATGA TCCTGGGATG GAAATTTTTT GATCATGCGG CACATCTTGG GGGAGCTCTT 1020

TTTGGAATAT GGTATGTTAC TTACGGTCAT GAACTGATTT GGAAGAACAG GGAGCCGCTA 1080 GTGAAAATCT GGCATGAAAT AAGGACTAAT GGCCCCAAAA AAGGAGGTGβ CTCTAAGTAA

Seq ID NO: 311 Protein sequence: Protein Accession ft: NP 061092.2

1 11 21 31 41 51 i i i i i i

MAWRGWAQRG WGCGQAWGAS VGGRSCEELT AVLTPPQLLG RRFNFFIQQK CGFRKAPRKV 60

EPRRSDPGTS GEAYKRSALI PPVEETVFYP SPYPIRSLIK PLFFTVGFTG CAFGSAAIWQ 120

YESLKSRVQS YFDGIKADWL DSIRPQKEGD FRKEINKWWN NLSDGQRTVT GIIAANVLVF 180

CLWRVPSLQR TMIRYFTSNP ASKVLCSPML LSTFSHFSLF HMAANMYVLW SFSSSIVNIL 240 GQEQFMAVYL SAGVISNFVS YLGKVATGRY GPSLGASGAI MTVLAAVCTK IPEGRLAIIP 300

LPMFTFTAGN ALKAIIAMDT AGMILGWKFF DHAAHLGGAL FGIWYVTYGH ELIWKNREPL 360 VKIWHEIRTN GPKKGGGSK

Seq ID NO: 312 DNA sequence Nucleic Acid Accession #: NM_000625 Coding sequence: 195..3656

1 11 21 31 41 51 i i i i i i

CTCTCGGCCA CCTTTGATGA GGGGACTGGG CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG 60

CACAGGTCTC TTCCTGGTTT GACTGTCCTT ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA 120

GCCCCACAGT GAAGAACATC TGAGCTCAAA TCCAGATAAG TGACATAAGT GACCTGCTTT 180

GTAAAGCCAT AGAGATGGCC TGTCCTTGGA AATTTCTGTT CAAGACCAAA TTCCACCAGT 240 ATGCAATGAA TGGGGAAAAA GGCATCAACA ACAATGTGGA GAAAGCCCCC TGTGCCACCT 300

CCAGTCCAGT GACACAGGAT GACCTTCAGT ATCACAACCT CAGCAAGCAG CAGAATGAGT 360

CCCCGCAGCC CCTCGTGGAG ACGGGAAAGA AGTCTCCAGA ATCTCTGGTC AAGCTGGATG 420

CAACCCCATT GTCCTCCCCA CGGCATGTGA GGATCAAAAA CTGGGGCAGC GGGATGACTT 480

TCCAAGACAC ACTTCACCAT AAGGCCAAAG GGATTTTAAC TTGCAGGTCC AAATCTTGCC 540 TGGGGTCCAT TATGACTCCC AAAAGTTTGA CCAGAGGACC CAGGGACAAG CCTACCCCTC 600

CAGATGAGCT TCTACCTCAA GCTATCGAAT TTGTCAACCA ATATTACGGC TCCCTCAAAG 660

AGGCAAAAAT AGAGGAACAT CTGGCCAGGG TGGAAGCGGT AACAAAGGAG ATAGAAACAA 720

CAGTAACCTA CCAACTGACG GGAGATGAGC TCATCTTCGC CACCAAGCAG GCCTGGCGCA 780

ATGCCCCACG CTGCATTGGG AGGATCCAGT GGTCCAACCT GCAGGTCTTC GATGCCCGCA 840 GCTGTTCCAC TGCCCGGGAA ATGTTTGAAC ACATCTGCAG ACACGTGCGT TACTCCACCA 900

ACAATGGCAA CATCAGGTCG GCCATCACCG TGTTCCCCCA GCGGAGTGAT GGCAAGCACG 960

ACTTCCGGGT GTGGAATGCT CAGCTCATCC GCTATGCTGG CTACCAGATG CCAGATGGCA 1020

GCATCAGAGG GGACCCTGCC AACGTGGAAT TCSCTCAGCT GTGCATCGAC CTGGGCTGGA 1080

AGCCCAAGTA CGGCCGCTTC GATGTGGTCC CCCTGGTCCT GCAGGCCAAT GGCCGTGACC 1140 CTGAGCTCTT CGAAATCCCA CCTGACCTTG TGCTTGAGGT GGCCATGGAA CATCCCAAAT 1200

ACGAGTGGTT TCGGGAACTG GAGCTAAAGT GGTACGCCCT GCCTGCAGTG GCCAACATGC 1260

TGCTTGAGGT GGGCGGCCTG GAGTTCCCAG GGTGCCCCTT CAATGGCTGG TACATGGGCA 1320

CAGAGATCGG AGTCCGGGAC TTCTGTGATG TCCAGCGCTA CAACATCCTG GAGGAAGTGG 1380

GCAGGAGAAT GGGCCTGGAA ACGCACAAGC TGGCCTCGCT CTGGAAAGAC CAGGCTGTCG 1440 TTGAGATCAA CATTGCTGTG CTCCATAGTT TCCAGAAGCA GAATGTGACC ATCATGGACC 1500

ACCACTCGGC TGCAGAATCC TTCATGAAGT ACATGCAGAA TGAATACCGG TCCCGTGGGG 1560

GCTGCCCGGC AGACTGGATT TGGCTGGTCC CTCCCATGTC TGGGAGCATC ACCCCCGTGT 1620

TTCACCAGGA GATGCTGAAC TACGTCCTGT CCCCTTTCTA CTACTATCAG GTAGAGGCCT 1680

GGAAAACCCA TGTCTGGCAG GACGAGAAGC GGAGACCCAA GAGAAGAGAG ATTCCATTGA 1740 AAGTCTTGGT CAAAGCTGTG CTCTTTGCCT GTATGCTGAT GCGCAAGACA ATGGCGTCCC 1800

GAGTCAGAGT CACCATCCTC TTTGCGACAG AGACAGGAAA ATCAGAGGCG CTGGCCTGGG 1860

ACCTGGGGGC CTTATTCAGC TGTGCCTTCA ACCCCAAGGT TGTCTGCATG GATAAGTACA 1920

GGCTGAGCTG CCTGGAGGAG GAACGGCTGC TGTTGGTGGT GACCAGTACG TTTGGCAATG 1980

GAGACTGCCC TGGCAATGGA GAGAAACTGA AGAAATCGCT CTTCATGCTG AAAGAGCTCA 2040 ACAACAAATT CAGGTACGCT GTGTTTGGCC TCGGCTCCAG CATGTACCCT CGGTTCTGCG 2100

CCTTTGCTCA TGACATTGAT CAGAAGCTGT CCCACCTGGG GGCCTCTCAG CTCACCCCGA 2160

TGGGAGAAGG GGATGAGCTC AGTGGGCAGG AGGACGCCTT CCGCAGCTGG GCCGTGCAAA 2220

CCTTCAAGGC AGCCTGTGAG ACGTTTGATG TCCGAGGCAA ACAGCACATT CAGATCCCCA 2280

AGCTCTACAC CTCCAATGTG ACCTGGGACC CGCACCACTA CAGGCTCGTG CAGGACTCAC 2340 AGCCTTTGGA CCTCAGCAAA GCCCTCAGCA GCATGCATGC CAAGAACGTG TTCACCATGA 2400

GGCTCAAATC TCGGCAGAAT CTACAAAGTC CGACATCCAG CCGTGCCACC ATCCTGGTGG 2460

AACTCTCCTG TGAGGATGGC CAAGGCCTGA ACTACCTGCC GGGGGAGCAC CTTGGGGTTT 2520

GCCCAGGCAA CCAGCCGGCC CTGGTCCAAG GCATCCTGGA GCGAGTGGTG GATGGCCCCA 2580

CACCCCACCA GGCAGTGCGC CTGGAGGCCC TGGATGAGAG TGGCAGCTAC TGGGTCAGTG 2640 ACAAGAGGCT GCCCCCCTGC TCACTCAGCC AGGCCCTCAC CTACTTCCTG GACATCACCA 2700

CACCCCCAAC CCAGCTGCTG CTCCAAAAGC TGGCCCAGGT GGCCACAGAA GAGCCTGAGA 2760

GACAGAGGCT GGAGGCCCTG TGCCAGCCCT CAGAGTACAG CAAGTGGAAG TTCACCAACA 2820

GCCCCACATT CCTGGAGGTG CTAGAGGAGT TCCCGTCCCT GCGGGTGTCT GCTGGCTTCC 2880

TGCTTTCCCA GCTCCCCATT CTGAAGCCCA GGTTCTACTC CATCAGCTCC CCCCGGGATC 2940 ACACGCCCAC GGAGATCCAC CTGACTGTGG CCGTGGTCAC CTACCACACC CGAGATGGCC 3000

AGGGTCCCCT GCACCACGGC GTCTGCAGCA CATGGCTCAA CAGCCTGAAG CCCCAAGACC 3060

CAGTGCCCTG CTTTGTGCGG AATGCCAGCG GCTTCCACCT CCCCGAGGAT CCCTCCCATC 3120 CTTGGATCCT CATCGGGCCT GGCACAGGCA TCGCGCCCTT CCGCAGTTTC TGGCAGCAAC 3180

GGCTCCATGA CTCCCAGCAC AAGGGAGTGC GGGGAGGCCG CATGACCTTG GTGTTTGGGT 3240

GCCGCCGCCC AGATGAGGAC CACATCTACC AGGAGGAGAT GCTGGAGATG GCCCAGAAGG 3300

GGGTGCTGCA TGCGGTGCAC ACAGCCTATT CCCGCCTGCC TGGCAAGCCC AAGGTCTATG 3360

TTCAGGACAT CCTGCGGCAG CAGCTGGCCA GCGAGGTGCT CCGTGTGCTC CACAAGGAGC 3420

CAGGCCACCT CTATGTTTGC GGGGATGTGC GCATGGCCCG GGACGTGGCC CACACCCTGA 3480

AGCAGCTGGT GGCTGCCAAG CTGAAATTGA ATGAGGAGCA GGTCGAGGAC TATTTCTTTC 3540

AGCTCAAGAG CCAGAAGCGC TATCACGAAG ATATCTTTGG TGCTGTATTT CCTTACGAGG 3600

CGAAGAAGGA CAGGGTGGCG GTGCAGCCCA GCAGCCTGGA GATGTCAGCG CTCTGAGGGC 3660

CTACAGGAGG GGTTAAAGCT GCCGGCACAG AACTTAAGGA TGGAGCCAGC TCTGCATTAT 3720

CTGAGGTCAC AGGGCCTGGG GAGATGGAGG AAAGTGATAT CCCCCAGCCT CAAGTCTTAT 3780

TTCCTCAACG TTGCTCCCCA TCAAGCCCTT TACTTGACCT CCTAACAAGT AGCACCCTGG 3840 ATTGATCGGA GCCTC

Seq ID NO: 313 Protein sequence: Protein Accession ft: NP 000616

11 21 31 41 51

I I I

MACPWKFLFK TKFHQYAMNG E IKGINNNVEK A 1PCATSSPVT QDDLQYHNLS KQQNESPQPL 60 VETGKKSPES LVKLDATPLS SPRHVRIKNW GSGMTFQDTL HHKAKGILTC RSKSCLGSIM 120 TPKSLTRGPR DKPTPPDELL PQAIEFVNQY YGSLKEAKIE EHLARVEAVT KEIETTVTYQ 180 LTGDELIFAT KQAWRNAPRC IGRIQWSNLQ VFDARSCSTA REMFEHICRH VRYSTNNGNI 240 RSAITVFPQR SDGKHDFRVW NAQLIRYAGY QMPDGSIRGD PANVEFTQLC IDLGWKPKYG 300 RFDWPLVLQ ANGRDPELFE IPPDLVLEVA MEHPKYEWFR ELELKWYALP AVANMLLEVG 360 GLEFPGCPFN GWYMGTEIGV RDFCDVQRYN ILEEVGRRMG LETHKLASLW KDQAWEINI 420 AVLHSFQKQN VTIMDHHSAA ESFMKYMQNE YRSRGGCPAD WIWLVPPMSG SITPVFHQEM 480 LNYVLSPFYY YQVEAWKTHV WQDEKRRPKR REIPLKVLVK AVLFACMLMR KTMASRVRVT 540 ILFATETGKS EALAWDLGAL FSCAFNPKW CMDKYRLSCL EEERLLLWT STFGNGDCPG 600 NGEKLKKSLF MLKELNNKFR YAVFGLGSSM YPRFCAFAHD IDQKLSHLGA SQLTPMGEGD 660 ELSGQEDAFR SWAVQTFKAA CETFDVRGKQ HIQIPKLYTS NVTWDPHHYR LVQDSQPLDL 720 SKALSSMHAK NVFTMRLKSR QNLQSPTSSR ATILVELSCE DGQGLNYLPG EHLGVCPGNQ 780 PALVQGILER WDGPTPHQA VRLEALDESG SYWVSDKRLP PCSLSQALTY FLDITTPPTQ 840 LLLQKLAQVA TEEPERQRLE ALCQPSEYSK WKFTNSPTFL EVLEEFPSLR VSAGFLLSQL 900 PILKPRFYSI SSPRDHTPTE IHLTVAWTY HTRDGQGPLH HGVCSTWLNS LKPQDPVPCF 960 VRNASGFHLP EDPSHPCILI GPGTGIAPFR SFWQQRLHDS QHKGVRGGRM TLVFGCRRPD 1020 EDHIYQEEML EMAQKGVLHA VHTAYSRLPG KPKVYVQDIL RQQLASEVLR VLHKEPGHLY 1080 VCGDVRMARD VAHTLKQLVA AKLKLNEEQV EDYFFQLKSQ KRYHEDIFGA VFPYEAKKDR 1140 VAVQPSSLEM SAL

Seq ID NO: 314 DNA sequence Nucleic Acid Accession ft: XM_087254 Coding sequence: 47..2332

11 21 31 41 51

AGAGTACGTG TTTACAGATA AAACTGGTAC ACTGACAGAA AATGAGATGC AGTTTCGGGA 60 ATGTTCAATT AATGGCATGA AATACCAAGA AATTAATGGT AGACTTGTAC CCGAAGGACC 120 AACACCAGAC TCTTCAGAAG GAAACTTATC TTATCTTAGT AGTTTATCCC ATCTTAACAA 180 CTTATCCCAT CTTACAACCA GTTCCTCTTT CAGAACCAGT CCTGAAAATG AAACTGAACT 240 AATTAAAGAA CATGATCTCT TCTTTAAAGC AGTCAGTCTC TGTCACACTG TACAGATTAG 300 CAATGTTCAA ACTGACTGCA CTGGTGATGG TCCCTGGCAA TCCAACCTGG CACCATCGCA 360 GTTGGAGTAC TATGCATCTT CACCAGATGA AAAGGCTCTA GTAGAAGCTG CTGCAAGGAT 420 TGGTATTGTG TTTATTGGCA ATTCTGAAGA AACTATGGAG GTTAAAACTC TTGGAAAACT 480 GGAACGGTAC AAACTGCTTC ATATTCTGGA ATTTGATTCA GATCGTAGGA GAATGAGTGT 540 AATTGTTCAG GCACCTTCAG GTGAGAAGTT ATTATTTGCT AAAGGAGCTG AGTCATCAAT 600 TCTCCCTAAA TGTATAGGTG GAGAAATAGA AAAAACCAGA ATTCATGTAG ATGAATTTGC 660 TTTGAAAGGG CTAAGAACTC TGTGTATAGC ATATAGAAAA TTTACATCAA AAGAGTATGA 720 GGAAATAGAT AAACGCATAT TTGAAGCCAG GACTGCCTTG CAGCAGCGGG AAGAGAAATT 780 GGCAGCTGTT TTCCAGTTCA TAGAGAAAGA CCTGATATTA CTTGGAGCCA CAGCAGTAGA 840 AGACAGACTA CAAGATAAAG TTCGAGAAAC TATTGAAGCA TTGAGAATGG CTGGTATCAA 900 AGTATGGGTA CTTACTGGGG ATAAACATGA AACAGCTGTT AGTGTGAGTT TATCATGTGG 960 CCATTTTCAT AGAACCATGA ACATCCTTGA ACTTATAAAC CAGAAATCAG ACAGCGAGTG 1020 TGCTGAACAA TTGAGGCAGC TTGCCAGAAG AATTACAGAG GATCATGTGA TTCAGCATGG 1080 GCTGGTAGTG GATGGGACCA GCCTATCTCT TGCACTCAGG GAGCATGAAA AACTATTTAT 1140 GGAAGTTTGC AGAAATTGTT CAGCTGTATT ATGCTGTCGT ATGGCTCCAC TGCAGAAAGC 1200 AAAAGTAATA AGACTAATAA AAATATCACC TGAGAAACCT ATAACATTGG CTGTTGGTGA 1260 TGGTGCTAAT GACGTAAGCA TGATACAAGA AGCCCATGTT GGCATAGGAA TCATGGGTAA 1320 AGAAGGAAGA CAGGCTGCAA GAAACAGTGA CTATGCAATA GCCAGATTTA AGTTCCTCTC 1380 CAAATTGCTT TTTGTTCATG GTCATTTTTA TTATATTAGA ATAGCTACCC TTGTACAGTA 1440 TTTTTTTTAT AAGAATGTGT GCTTTATCAC ACCCCAGTTT TTATATCAGT TCTACTGTTT 1500 GTTTTCTCAG CAAACATTGT ATGACAGCGT GTACCTGACT TTATACAATA TTTGTTTTAC 1560 TTCCCTACCT ATTCTGATAT ATAGTCTTTT GGAACAGCAT GTAGACCCTC ATGTGTTACA 1620 AAATAAGCCC ACCCTTTATC GAGACATTAG TAAAAACCGC CTCTTAAGTA TTAAAACATT 1680 TCTTTATTGG ACCATCCTGG GCTTCAGTCA TGCCTTTATT TTCTTTTTTG GATCCTATTT 1740 ACTAATAGGG AAAGATACAT CTCTGCTTGβ AAATGGCCAG ATGTTTGGAA ACTGGACATT 1800 TGGCACTTTG GTCTTCACAG TCATGGTTAT TACAGTCACA GTAAAGATGG CTCTGGAAAC 1860 TCATTTTTGG ACTTGGATCA ACCATCTCGT TACCTGGGGA TCTATTATAT TTTATTTTGT 1920 ATTTTCCTTG TTTTATGGAG GGATTCTCTG GCCATTTTTG GGCTCCCAGA ATATGTATTT 1980 TGTGTTTATT CAGCTCCTGT CAAGTGGTTC TGCTTGGTTT GCCATAATCC TCATGGTTGT 2040 TACATGTCTA TTTCTTGATA TCATAAAGAA GGTCTTTGAC CGACACCTCC ACCCTACAAG 2100 TACTGAAAAG GCACAGCTTA CTGAAACAAA TGCAGGTATC AAGTGCTTGG ACTCCATGTG 2160 CTGTTTCCCG GAAGGAGAAG CAGCGTGTGC ATCTGTTGGA AGAATGCTGG AACGAGTTAT 2220 AGGAAGATGT AGTCCAACCC ACATCAGCAG ATCATGGAGT GCATCGGATC CTTTCTATAC 2280 CAACGACAGG AGCATCTTGA CTCTCTCCAC AATGGACTCA TCTACTTGTT AAAGGGGCAG 2340 TAGTACTTTG TGGGAGCCAG TTCACCTCCT TTCCTAAAAT TCAGTGTGAT CACCCTGTTA 2400 ATGGCCACAC TAGCTCTGAA ATTAATTTCC AAAATCTTTG TAGTAGTTCA TACCCACTCA 2460 GAGTTATAAT GGCAAACAAA CAGAAAGCAT TAGTACAAGC CCCTCCCAAC ACCCTTAATT 2520 TGAATCTGAA CATGTTAAAA TTTGAGAATA AAGAGACATT TTTCATCTCT TTGTCTGGTT 2580 TGTCCCTTGT GCTTATGGGA CTCCTAATGG CATTTCAGTC TGTTGCTGAG GCCATTATAT 2640 TTTAATATAA ATGTAGAAAA AAGAGAGAAA TCTTAGTAAA GAGTATTTTT TAGTATTAGC 2700 TTGATTATTG ACTCTTCTAT TTAAATCTGC TTCTGTAAAT TATGCTGAAA GTTTGCCTTG 2760 AGAACTCTAT TTTTTTATTA GAGTTATATT TAAAGCTTTT CATGGGAAAA GTTAATGTGA 2820 ATACTGAGGA ATTTTGGTCC CTCAGTGACC TGTGTTGTTA ATTCATTAAT GCATTCTGAG 2880 TTCACAGAGC AAATTAGGAG AATCATTTCC AACCATTATT TACTGCAGTA TGGGGAGTAA 2940 ATTTATACCA ATTCCTCTAA CTGTACTGTA ACACAGCCTG TAAAGTTAGC CATATAAATG 3000 CAAGGGTATA TCATATATAC AAATCAGGAA TCAGGTCCGT TCACCGAACT TCAAATTGAT 3060 GTTTACTAAT ATTTTTGTGA CAGAGTATAA AGACCCTATA GTGGGTAAAT TAGATACTAT 3120 TAGCATATTA TTAATTTAAT GTCTTTATCA TTGGATCTTT TGCATGCTTT AATCTGGTTA 3180 ACATATTTAA ATTTGCTTTT TTTCTCTTTA CCTGAAGGCT CTGTGTATAG TATTTCATGA 3240 CATCGTTGTA CAGTTTAACT ATATCAATAA AAAGTTTGGA CAGTATTTAA ATATTGCAAA 3300 TATGTTTAAT TATACAAATC AGAATAGTAT GGGTAATTAA ATGAATACAA AAAGAAGAGC 3360 CTCTTTCTGC AGCCGACTTA GACATGCTCT TCCCTTTCTA TAAGCTAGAT TTTAGAATAA 3420 AGGGTTTCAG TTAATAATCT TATTTTCAGG TTATGTCATC TAACTTATAG CAAACTACCA 3480 CAATACAGTG AGTTCTGCCA GTGTCCCAGT ACAAGGCATA TTTCAGGTGT GGCTGTGGAA 3540 TGTAAAAATG CTCAACTTGT ATCAGGTAAT GTTAGCAATA AATTAAATGC TAAGAATGAT 3600 TAATCGGGTA CATGTTACTG TAATTAACTC ATTGCACTTC AAAACCTAAC TTCCATCCTG 3660 AATTTATCAA GTAGTTCAGT ATTGTCATTT GTTTTTGTTT TATTGAAAAG TAATGTTGTC 3720 TTAAGATTTA GAAGTGATTA TTAGCTTGAG AACTATTACC CAGCTCTAAG CAAATAATGA 3780 TTGTATACAT ATTAAGATAA TGGTTAAATG CGGTTTTACC AAGTTTTCCC TTGAAAATGT 3840 AATTCCTTTA TGGAGATTTA TTGTGCAGCC CTAAGCTTCC TTCCCATTTC ATGAATATAA 3900 GGCTTCTAGA ATTGGACTGG CAGGGGAAAG AATGGTAGAG ACAGAAATTA AGACTTTATC 3960 CTTGTTTGCT TGTAAACTAT TATTTTCTTG CTAATGTAAC ATTTGTCTGT TCCAGTGATG 4020 TAAGGATATT AAGTTATTAA GCTAAATATT AATTTTCAAA AATAGTCCTT CTTTAACTTA 4080 GATATTTCAT AGCTGGATTT AGGAAGATCT GTTATTCTGG AAGTACTAAA AAGAATAATA 4140 CAACGTACAA TGTCTGCATT CACTAATTCA TGTTCCAGAA GAGGAAATAA TGAAGATATA 4200 CTCAGTAGAG TACTAGGTGG GAGGATATGG AAATTTGCTC ATAAAATCTC TTATAAAACG 4260 TGCATATAAC AAAATGACAC CCAGTAGGCC TGCATTACAT TTACATGACC GTGTTTATTT 4320 GCCATCAAAT AAACTGAGTA CTGACACCAG ACAAAGACTC CAAAGTCATA AAATAGCCTA 4380 TGACCAACTG CAGCAAGACA GGAGGTCAGC TCGCCTATAA TGGTGCTTAA AGTGTGATTG 4440 ATGTAATTTT CTGTACTCAC CATTTGAAGT TAGTTAAGGA GAACTTTATT TTTTTAAAAA 4500 AAGTAAATGG CAACCACTAG TGTGCTCATC CTGAACTGTT ACTCCAAATC CACTCCGTTT 4560 TTAAAGCAAA ATTATCTTGT GATTTTAAGA AAAGAGTTTT CTATTTATTT AAGAAAGTAA 4620 CAATGCAGTC TGCAAGCTTT CAGTAGTTTT CTAGTGCTAT ATTCATCCTG TAAAACTCTT 4680 ACTACGTAAC CAGTAATCAC AAGGAAAGTG TCCCCTTTGC ATATTTCTTT AAAATTCTTT 4740 CTTTGGAAAG TATGATGTTG ATAATTAACT TACCCTTATC TGCCAAAACC AGAGCAAAAT 4800 GCTAAATACG TTATTGCTAA TCAGTGGTCT CAAATCGATT TGCCTCCCTT TGCCTCGTCT 4860 GAGGGCTGTA AGCCTGAAGA TAGTGGCAAG CACCAAGTCA GTTTCCAAAA TTGCCCCTCA 4920 GCTGCTTTAA GTGACTCAGC ACCCTGCCTC AGCTTCAGCA GGCGTAGGCT CACCCTGGGC 4980 GGAGCAAAGT ATGGGCCAGG GAGAACTACA GCTACGAAGA CCTGCTGTCG AGTTGAGAAA 5040 AGGGGAGAAT TTATGGTCTG AATTTTCTAA CTGTCCTCTT TCTTGGGTCT AAAGCTCATA 5100 ATACACAAAG GCTTCCAGAC CTGAGCCACA CCCAGGCCCT ATCCTGAACA GGAGACTAAA 5160 CAGAGGCAAA TCAACCCTAG GAAATACTTG CATTCTGCCC TACGGTTAGT ACCAGGACTG 5220 AGGTCATTTC TACTGGAAAA GATTGTGAGA TTGAACTTAT CTGATCGCTT GAGACTCCTA 5280 ATAGGCAGGA GTCAAGGCCA CTAGAAAATT GACAGTTAAG AGCCAAAAGT TTTTAAAATA 5340 TGCTACTCTG AAAAATCTCG TGAAGGCTGT AGGAAAAGGG AGAATCTTCC ATGTTGGTGT 5400 TTTTCCTGTA AAGATCAGTT TGGGGTATGA TATAAGCAGG TATTAATAAA AATAACACAC 5460 CAAAGAGTTA CGTAAAACAT GTTTTATTAA TTTTGGTCCC CACGTACAGA CATTTTATTT 5520 CTATTTTGAA ATGAGTTATC TATTTTCATA AAAGTAAAAC ACTATTAAAG TGCTGTTTTA 5580 TGTGAAATAA CTTGAATGTT GTTCCTATAA AAAATAGATC ATAACTCATG ATATGTTTGT 5640 AATCATGGTA ATTTAGATTT TTATGAGGAA TGAGTATCTG GAAATATTGT AGCAATACTT 5700 GGTTTAAAAT TTTGGACCTG AGACACTGTG GCTGTCTAAT GTAATCCTTT AAAAATTCTC 5760 TGCATTGTCA GTAAATGTAG TATATTATTG TACAGCTACT CATAATTTTT TAAAGTTTAT 5820 GAAGTTATAT TTATCAAATA AAAACTTTCC TATAT

Seq ID NO : 315 Protein sequence : Protein Accession ft : XP 087254

31 51

MQFRECSING MKYQEINGRL VPEGPTPDSS EGNLSYLSSL SHLNNLSHLT TSSSFRTSPE 60

NETELIKEHD LFFKAVSLCH TVQISNVQTD CTGDGPWQSN LAPSQLEYYA SSPDEKALVE 120

AAARIGIVF1 GNSEETMEVK TLGKLERYKL LHILEFDSDR RRMSVIVQAP SGEKLLFAKG 180

AESSILPKCI GGEIEKTRIH VDEFALKGLR TLCIAYRKFT SKEYEEIDKR IFEARTALQQ 240

REEKLAAVFQ FIEKDLILLG ATAVEDRLQD KVRETIEALR MAGIKVWVLT GDKHETAVSV 300

SLSCGHFHRT MNILELINQK SDSECAEQLR QLARRITEDH VIQHGLWDG TSLSLALREH 360

EKLFMEVCRN CSAVLCCRMA PLQKAKVIRL IKISPEKPIT LAVGDGANDV SMIQEAHVGI 420

GIMGKEGRQA ARNSDYAIAR FKFLSKLLFV HGHFYYIRIA TLVQYPFYKN VCFITPQFLY 480

QFYCLFSQQT LYDSVYLTLY NICFTSLPIL IYSLLEQHVD PHVLQNKPTL YRDISKNRLL 540

SIKTFLYWTI LGFSHAFIFF FGSYLLIGKD TSLLGNGQMF GNWTFGTLVF TVMVITVTVK 600

MALETHFWTW INHLVTWGSI IFYFVFSLFY GGILWPFLGS QNMYFVFIQL LSSGSAWFAI 660

ILMWTCLFL DIIKKVFDRH LHPTSTEKAQ LTETNAGIKC LDSMCCFPEG EAACASVGRM 720

LERVIGRCSP THISRSWSAS DPFYTNDRSI LTLSTMDSST C

Seq ID NO: 316 DNA sequence Nucleic Acid Accession ft: NM_004473 Coding sequence: 661..1791

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CTCGCCAGCG GTCCGCGGGG CTGGAGACCC ACGCCGTGGA GAGGACCAGC CTCAGGTCGC 60 CCCGCCTGGG CCCGCGCCCC GACCTCGCTG CCCCCGCCTC GCCTCTCTGC CCGTGGCGCT 120

^•TACCGCCACC TTGGCCTCGG GGGCAGGGCA TGGGCGGCCC CCGCCAGATC GCCCAGCGCC 180

AGTACTAACT GCCCTCGCTC TGGCCTTCGA GCCCGAAGCC TCTTCTGCGC GCACAACCTA 240

GGCAGTAATC CTAAACTAGC GGGCACCACA GACCAGCTGC AGCCACCCCA ACCCAGGGAT 300

CACTTCCGGA CCCCTCGACC GCCCGGCACC AGCGCGCAAG GGACCCTTCA GCCGGAGACC 360

AGAGTCCAGT CCCGGTCGCG AGGCCACCGC CGCTGCCCGC CTCGAGAAGC ACAACGCGGG 420

CTGAGCCGTC GGCTAGCGGG TCACTCCCGA GCCTCTGTCT GCACCGCGCC AGCCCCAGAC 480

CACGGACGCT GAGCCTCCAG CGCGCGCCAG CCTGGGCCGC TGGGCTCTCC GGGCCAGCCC 540

GCGACGATCC CCTGAGCTCT CCGCAGAAGG GCCGAGCGTC CGTTCCGGGG ACGCCAGGCC 600

CGCCCCCGCC CCCCGACAGC CGCGGGGATC CAGAGCCCGG GGGTGCGGGA CGCGCGCGCC 660

ATGACTGCCG AGAGCGGGCC GCCGCCGCCG CAGCCGGAGG TGCTGGCTAC CGTGAAGGAA 720

GAGCGCGGCG AGACGGCAGC AGGGGCCGGG GTCCCAGGGG AGGCCACGGG CCGCGGGGCG 780

GGCGGGCGGC GCCGCAAGCG CCCCCTGCAG CGCGGGAAGC CGCCCTACAG CTACATCGCG 840

CTCATCGCCA TGGCCATCGC GCACGCGCCC GAGCGCCGCC TCACGCTGGG CGGCATCTAC 900

AAGTTCATCA CCGAGCGCTT CCCCTTCTAC CGCGACAACC CCAAAAAGTG GCAGAACAGC 960

ATCCGCCACA ACCTCACACT CAACGACTGC TTCCTCAAGA TCCCGCGCGA GGCCGGCCGC 1020

CCGGGTAAGG GCAACTACTG GGCGCTCGAC CCCAACGCGG AGGACATGTT CGAGAGCGGC 1080

AGCTTCCTGC GCCGCCGCAA GCGCTTCAAG CGCTCGGACC TCTCCACCTA CCCGGCTTAC 1140

ATGCACGACG CGGCGGCTGC CGCAGCCGCC GCTGCCGCAG CCGCCGCCGC CGCCGCCGCC 1200

GCCGCCATCT TCCCAGGCGC GGTGCCCGCC GCGCGCCCCC CCTACCCGGG CGCCGTCTAT 1260

GCAGGCTACG CGCCGCCGTC GCTGGCCGCG CCGCCTCCAG TCTACTACCC CGCGGCGTCG 1320

CCCGGCCCTT GCCGCGTCTT CGGCCTGGTT CCTGAGCGGC CGCTCAGCCC AGAGCTGGGG 1380

CCCGCACCGT CGGGGCCCGG CGGCTCTTGC GCCTTTGCCT CCGCCGGCGC CCCCGCTACC 1440

ACCACCGGCT ACCAGCCCGC AGGCTGCACC GGGGCCCGGC CGGCCAACCC CTCTGCCTAT 1500

GCGGCTGCCT AGGCGGGCCC CGACGGCGCG TACCCGCAGG GCGCCGGCAG TGCGATCTTT 1560

GCCGCTGCTG GCCGCCTGGC GGGACCCGCT TCGCCCCCAG CGGGCGGCAG CAGTGGCGGC 1620

GTGGAGACCA CGGTGGACTT CTACGGGCGC ACGTCGCCCG GCCAGTTCGG AGCGCTGGGA 1680

GCCTGCTACA ACCCTGGCGG GCAGCTCGGA GGGGCCAGTG CAGGCGCCTA CCATGCTCGC 1740

CATGCTGCCG CTTATCCCGG TGGGATAGAT CGGTTCGTGT CCGCCATGTG AGCCAGCGTA 1800

GGGACGAAAA CTCATAGACA CATCGGCTGT TCACACGTTC CCCGCAACCT GAGAACGAAC 1860

AGGAATGGAG AGAGGACTCA ACTGGGACCC ACGTGGAAAA GACCGAGCAG GCCACAGAGG 1920

CTCGGTCTCC CCGCGCACAG CGTAGGCACC CTGTGTACTC TGTAAACGGG AGGAGGTGGG 1980

GCGAGGCAGC CAGAGCCCTT GGACTGGCAC AGGGACCCTC GATGGAGCGA AGCCCTCAAA 2040

CGGGATGCTT TCTGGCATTC TATCGGGGAG GGTCCTTGGC GGTAACCAGA GGGCAGCGTA 2100

GTGTCAACAC CAGAGACCAG GATCCAAATT GTGGGGAATC AGTTTCAGCC TTCCATGTGC 2160

TGCCGGAACT CGGGCCTTTT TACGCGGTTC GTCCTCTAGT GCCTTTAACT GCGTTACTAC 2220

AATAAAAGGC TGCGGCAGCG CCTTTCTTCT TAAAGTGAGG AGGACAAATT TGCAAAAGAA 2280

ATAGGCTTTT CTTCTTTTTT AAATTGGAGA AATCTCTGCT CTGGTTGACC TGGGCTGGTT 2340

TTCCCTGTCT CTGAGAACTT GAGACCTAGC TCCGAGTTGA ACTGTGCGTC AGCACTCCAG 2400

TCCCATCACC TGAACCTTCA GTCTCCCCCA TCTGTTACAC TAGAGGGCTG CAGGACTCTA 2460

TCCACCGCCC CCGGGTTATC ATTCAGGGCC CCATCATCTT GGATGCTGCC CTGCGTATTT 2520

GGCAGCAATG CTGGGCCACC CAGGGCCTCT GAGTAGCCAC CCAAAGCCTA GCCGCTGTTC 2580

TAGGGAACGG AAAAGAGTTC ATGGCCAAGC GTCTAACCTA AAGTCCCAGG ATTGGCTCCA 2640

GGCAGCAATT ATATCATAAC TTATTGAACT TTTGAGCAGG ACGTGCTGGT AATTTCATGG 2700

CTGTTACTGC CCAGTCATAA ATCTGCTTTT CCATTATAAG GCAGAGAGAA GTACATTCGT 2760

TCATTTGTCC ACTGTTTCTT GTCATCACGC AGCCCTGGAC CCAAAGGGTG AACTAAAGTT 2820

TAAGGAGATG AGAGGATTCA AGGAGCCCGT TGGTGACGCC TTTCAGTAGC TGGGGAGGGC 2880

TCTTCCATCC CCAGCACCCC CTGCTACACC TCAGCAGCCT CCCCCATGCA AAAAGGAAAG 2940

AGAAAAATTA AGTTAGGGCA GTCAGTAAAG TGAGCTTTAG AAAGAAACTG GAATTTTAAC 3000

TTCATTTTGT ATCTTGCTTA AGTAGCAGGC TCACTAAAAT TAGAGAAAGT CCAATAACTC 3060

TCCCCCTTTC CCTTGAGAAA TCTTTAAGTT TCGATTCTGG AGCAAAAACT TTCAGCATTA 3120

AATATTTCAG AGGCTCCATT CACAGCTTTC AGATAAACTG GAGTGTTCAG ATGGACTGTT 3180

TTAATAAAAA TCTTTGAGCA AGTGAGTTAT GGCAAGAGAA ACTCAGCCTC TTTCTGTATA 3240

AACTTAACAG GGAAGGGCTG GGGTGTGAAA AAGAAGATTG TATGAAAACC ATTGGTAATT 3300

TTTATTTTTT ATTTTTGGGA CTGCACTATC CTGTTCACGA AGACATGTGA ACTTGGTTCA 3360

GTCCAAATGG GGATTTGTAT AAACCAGTGC TCTCCATTAG AAATATGGTG CAAGCCACAT 3420

ATGTAATTTT AAATATTCTA GTAGCCACAT TAATAAAGTN AAAAGAAACA AAAAAAAAAA 3480 AA

Seq ID NO: 317 Protein sequence: Protein Accession ft: NP_004464

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FKHLTHYROI DTRANSCRIP TIONFACTOR TTFMTAESGP PPPQPEVLAT VKEERGETAA 60

GAGVPGEATG RGAGGRRRKR PLQRGKPPYS YIALIAMAIA HAPERRLTLG GIYKFITERF 120

PFYRDNPKKW QNSIRHNLTL NDCFLKIPRE AGRPGKGNYW ALDPNAEDMF ESGSFLRRRK 180

RFKRSDLSTY PAYMHDAAAA AAAAAAAAAA AAAAAIFPGA VPAARPPYPG AVYAGYAPPS 240

LAAPPPVYYP AASPGPCRVF GLVPERPLSP ELGPAPSGPG GSCAFASAGA PATTTGYQPA 300

GCTGARPANP SAYAAAYAGP DGAYPQGAGS AIFAAAGRLA GPASPPAGGS SGGVETTVDF 360 YGRTSPGQFG ALGACYNPGG QLGGASAGAY HARHAAAYPG GIDRFVSAM

Seq ID NO: 318 DNA sequence Nucleic Acid Accession ft: NM_005688 Coding sequence: 126.. 439

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CCGGGCAGGT GGCTCATGCT CGGGAGCGTG GTTGAGCGGC TGGCGCGGTT GTCCTGGAGC 60

AGGGGCGCAG GAATTCTGAT GTGAAACTAA CAGTCTGTGA GCCCTGGAAC CTCCGCTCAG 120

AGAAGATGAA GGATATCGAC ATAGGAAAAG AGTATATCAT CCCCAGTCCT GGGTATAGAA 180

GTGTGAGGGA GAGAACCAGC ACTTCTGGGA CGCACAGAGA CCGTGAAGAT TCCAAGTTCA 240

GGAGAACTCG ACCGTTGGAA TGCCAAGATG CCTTGGAAAC AGCAGCCCGA GCCGAGGGCC 300

TCTCTCTTGA TGCCTCCATG CATTCTCAGC TCAGAATCCT GGATGAGGAG CATCCCAAGG 360

GAAAGTACCA TCATGGCTTG AGTGCTCTGA AGCCCATCCG GACTACTTCC AAACACCAGC 420

ACCCAGTGGA CAATGCTGGG CTTTTTTCCT GTATGACTTT TTCGTGGCTT TCTTCTCTGG 480 CCCGTGTGGC CCACAAGAAG GGGGAGCTCT CAATGGAAGA CGTGTGGTCT CTGTCCAAGC 540

ACGAGTCTTC TGACGTGAAC TGCAGAAGAC TAGAGAGACT GTGGCAAGAA GAGCTGAATG 600

AAGTTGGGCC AGACGCTGCT TCCCTGCGAA GGGTTGTGTG GATCTTCTGC CGCACCAGGC 660

TCATCCTGTC CATCGTGTGC CTGATGATCA CGCAGCTGGC TGGCTTCAGT GGACCAGCCT 720

TCATGGTGAA ACACCTCTTG GAGTATACCC AGGCAACAGA GTCTAACCTG CAGTACAGCT 780

TGTTGTTAGT GCTGGGCCTC CTCCTGACGG AAATCGTGCG GTCTTGGTCG CTTGCACTGA 840

CTTGGGCATT GAATTACCGA ACCGGTGTCC GCTTGCGGGG GGCCATCCTA ACCATGGCAT 900

TTAAGAAGAT CCTTAAGTTA AAGAACATTA AAGAGAAATC CCTGGGTGAG CTCATCAACA 960

TTTGCTCCAA CGATGGGCAG AGAATGTTTG AGGCAGCAGC CGTTGGCAGC CTGCTGGCTG 1020

GAGGACCCGT TGTTGCCATC TTAGGCATGA TTTATAATGT AATTATTCTG GGACCAACAG 1080

GCTTCCTGGG ATCAGCTGTT TTTATCCTCT TTTACCCAGC AATGATGTTT GCATCACGGC 1140

TCACAGCATA TTTCAGGAGA AAATGCGTGG CCGCCACGGA TGAACGTGTC CAGAAGATGA 1200

ATGAACTTCT TACTTACATT AAATTTATCA AAATGTATGC CTGGGTCAAA GCATTTTCTC 1260

AGAGTGTTCA AAAAATCCGC GAGGAGGAGC GTCGGATATT GGAAAAAGCC GGGTACTTCC 1320

AGGGTATCAC TGTGGGTGTG GCTCCCATTG TGGTGGTGAT TGCCAGCGTG GTGACCTTCT 1380

CTGTTCATAT GACCCTGGGC TTCGATCTGA CAGCAGCACA GGCTTTCACA GTGGTGACAG 1440

TCTTCAATTC CATGACTTTT GCTTTGAAAG TAACACCGTT TTCAGTAAAG TCCCTCTCAG 1500

AAGCCTCAGT GGCTGTTGAC AGATTTAAGA GTTTGTTTCT AATGGAAGAG GTTCACATGA 1560

TAAAGAACAA ACCAGCCAGT CCTCACATCA AGATAGAGAT GAAAAATGCC ACCTTGGCAT 1620

GGGACTCCTC CCACTCCAGT ATCCAGAACT CGCCCAAGCT GACCCCCAAA ATGAAAAAAG 1680

ACAAGAGGGC TTCCAGGGGC AAGAAAGAGA AGGTGAGGCA GCTGCAGCGC ACTGAGCATC 1740

AGGCGGTGCT GGCAGAGCAG AAAGGCCACC TCCTCCTGGA CAGTGACGAG CGGCCCAGTC 1800

CCGAAGAGGA AGAAGGCAAG CACATCCACC TGGGCCACCT GCGCTTACAG AGGACACTGC 1860

ACAGCATCGA TCTGGAGATC CAAGAGGGTA AACTGGTTGG AATCTGCGGC AGTGTGGGAA 1920

GTGGAAAAAC CTCTCTCATT TCAGCCATTT TAGGCCAGAT GACGCTTCTA GAGGGCAGCA 1980

TTGCAATCAG TGGAACCTTC GCTTATGTGG CCCAGCAGGC CTGGATCCTC AATGCTACTC 2040

TGAGAGACAA CATCCTGTTT GGGAAGGAAT ATGATGAAGA AAGATACAAC TCTGTGCTGA 2100

ACAGCTGCTG CCTGAGGCCT GACCTGGCCA TTCTTCCCAG CAGCGACCTG ACGGAGATTG 2160

GAGAGCGAGG AGCCAACCTG AGCGGTGGGC AGCGCCAGAG GATCAGCCTT GCCCGGGCCT 2220

TGTATAGTGA CAGGAGCATC TACATCCTGG ACGACCCCCT CAGTGCCTTA GATGCCCATG 2280

TGGGCAACCA CATCTTCAAT AGTGCTATCC GGAAACATCT CAAGTCCAAG ACAGTTCTGT 2340

TTGTTACCCA CCAGTTACAG TACCTGGTTG ACTGTGATGA AGTGATCTTC ATGAAAGAGG 2400

GCTGTATTAC GGAAAGAGGC ACCCATGAGG AACTGATGAA TTTAAATGGT GACTATGCTA 2460

CCATTTTTAA TAACCTGTTG CTGGGAGAGA CACCGCCAGT TGAGATCAAT TCAAAAAAGG 2520

AAACCAGTGG TTCACAGAAG AAGTCACAAG ACAAGGGTCC TAAAACAGGA TCAGTAAAGA 2580

AGGAAAAAGC AGTAAAGCCA GAGGAAGGGC AGCTTGTGCA GCTGGAAGAG AAAGGGCAGG 2640

GTTCAGTGCC CTGGTCAGTA TATGGTGTCT ACATCCAGGC TGCTGGGGGC CCCTTGGCAT 2700

TCCTGGTTAT TATGGCCCTT TTCATGCTGA ATGTAGGCAG CACCGCCTTC AGCACCTGGT 2760

GGTTGAGTTA CTGGATCAAG CAAGGAAGCG GGAACACCAC TGTGACTCGA GGGAACGAGA 2820

CCTCGGTGAG TGACAGCATG AAGGACAATC CTCATATGCA GTACTATGCC AGCATCTACG 2880

CCCTCTCCAT GGCAGTCATG CTGATCCTGA AAGCCATTCG AGGAGTTGTC TTTGTCAAGG 2940

GCACGCTGCG AGCTTCCTCC CGGCTGCATG ACGAGCTTTT CCGAAGGATC CTTCGAAGCC 3000

CTATGAAGTT TTTTGACACG ACCCCCACAG GGAGGATTCT CAACAGGTTT TCCAAAGACA 3060

TGGATGAAGT TGACGTGCGG CTGCCGTTCC AGGCCGAGAT GTTCATCCAG AACGTTATCC 3120

TGGTGTTCTT CTGTGTGGGA ATGATCGCAG GAGTCTTCCC GTGGTTCCTT GTGGCAGTGG 3180

GGCCCCTTGT CATCCTCTTT TCAGTCCTGC ACATTGTCTC CAGGGTCCTG ATTCGGGAGC 3240

TGAAGCGTCT GGACAATATC ACGCAGTCAC CTTTCCTCTC CCACATCACG TCCAGCATAC 3300

AGGGCCTTGC CACCATCCAC GCCTACAATA AAGGGCAGGA GTTTCTGCAC AGATACCAGG 3360

AGCTGCTGGA TGACAACCAA GCTCCTTTTT TTTTGTTTAC GTGTGCGATG CGGTGGCTGG 3420

CTGTGCGGCT GGACCTCATC AGCATCGCCC TCATCACCAC CACGGGGCTG ATGATCGTTC 3480

TTATGCACGG GCAGATTCCC CCAGCCTATG CGGGTCTCGC CATCTCTTAT GCTGTCCAGT 3540

TAACGGGGCT GTTCCAGTTT ACGGTCAGAC TGGCATCTGA GACAGAAGCT CGATTCACCT 3600

CGGTGGAGAG GATCAATCAC TACATTAAGA CTCTGTCCTT GGAAGCACCT GCCAGAATTA 3660

AGAACAAGGC TCCCTCCCCT GACTGGCCCC AGGAGGGAGA GGTGACCTTT GAGAACGCAG 3720

AGATGAGGTA CCGAGAAAAC CTCCCTCTTG TCCTAAAGAA AGTATCCTTC ACGATCAAAC 3780

CTAAAGAGAA GATTGGCATT GTGGGGCGGA CAGGATCAGG GAAGTCCTCG CTGGGGATGG 3840

CCCTCTTCCG TCTGGTGGAG TTATCTGGAG GCTGCATCAA GATTGATGGA GTGAGAATCA 3900

GTGATATTGG CCTTGCCGAC CTCCGAAGCA AACTCTCTAT CATTCCTCAA GAGCCGGTGC 3960

TGTTCAGTGG CACTGTCAGA TCAAATTTGG ACCCCTTCAA CCAGTACACT GAAGACCAGA 4020

TTTGGGATGC CCTGGAGAGG ACACACATGA AAGAATGTAT TGCTCAGCTA CCTCTGAAAC 4080

TTGAATCTGA AGTGATGGAG AATGGGGATA ACTTCTCAGT GGGGGAACGG CAGCTCTTGT 4140

GCATAGCTAG AGCCCTGCTC CGCCACTGTA AGATTCTGAT TTTAGATGAA GCCACAGCTG 4200

CCATGGACAC AGAGACAGAC TTATTGATTC AAGAGACCAT CCGAGAAGCA TTTGCAGACT 4260

GTACCATGCT GACCATTGCC CATCGCCTGC ACACGGTTCT AGGCTCCGAT AGGATTATGG 4320

TGCTGGCCCA GGGACAGGTG GTGGAGTTTG ACACCCCATC GGTCCTTCTG TCCAACGACA 4380

GTTCCCGATT CTATGCCATG TTTGCTGCTG CAGAGAACAA GGTCGCTGTC AAGGGCTGAC 4440

TCCTCCCTGT TGACGAAGTC TCTTTTCTTT AGAGCATTGC CATTCCCTGC CTGGGGCGGG 4500

CCCCTCATCG CGTCCTCCTA CCGAAACCTT GCCTTTCTCG ATTTTATCTT TCGCACAGCA 4560

GTTCCGGATT GGCTTGTGTG TTTCACTTTT AGGGAGAGTC ATATTTTGAT TATTGTATTT 4620

ATTCCATATT CATGTAAACA AAATTTAGTT TTTGTTCTTA ATTGCACTCT AAAAGGTTCA 4680

GGGAACCGTT ATTATAATTG TATCAGAGGC CTATAATGAA GCTTTATACG TGTAGCTATA 4740

TCTATATATA ATTCTGTACA TAGCCTATAT TTACAGTGAA AATGTAAGCT GTTTATTTTA 4800

TATTAAAATA AGCACTGTGC TAATAACAGT GCATATTCCT TTCTATCATT TTTGTACAGT 4860

TTGCTGTACT AGAGATCTGG TTTTGCTATT AGACTGTAGG AAGAGTAGCA TTTCATTCTT 4920

CTCTAGCTGG TGGTTTCACG GTGCCAGGTT TTCTGGGTGT CCAAAGGAAG ACGTGTGGCA 4980

ATAGTGGGCC CTCCGACAGC CCCCTCTGCC GCCTCCCCAC AGCCGCTCCA GGGGTGGCTG 5040

GAGACGGGTG GGCGGCTGGA GACCATGCAG AGCGCCGTGA GTTCTCAGGG CTCCTGCCTT 5100

CTGTGCTGGT GTCACTTACT GTTTCTGTCA GGAGAGCAGC GGGGCGAAGC CCAGGCCCCT 5160

TTTCACTCCC TCCATCAAGA ATGGGGATCA CAGAGACATT CCTCCGAGCC GGGGAGTTTC 5220

TTTCCTGCCT TCTTCTTTTT GCTGTTGTTT CTAAACAAGA ATCAGTCTAT CCACAGAGAG 5280

TCCCACTGCC TCAGGTTCCT ATGGCTGGCC ACTGCACAGA GCTCTCCAGC TCCAAGACCT 5340

GTTGGTTCCA AGCCCTGGAG CCAACTGCTG CTTTTTGAGG TGGCACTTTT TCATTTGCCT 5400

ATTCCCACAC CTCCACAGTT CAGTGGCAGG GCTCAGGATT TCGTGGGTCT GTTTTCCTTT 5460

CTCACCGCAG TCGTCGCACA GTCTCTCTCT CTCTCTCCCC TCAAAGTCTG CAACTTTAAG 5520

CAGCTCTTGC TAATCAGTGT CTCACACTGG CGTAGAAGTT TTTGTACTGT AAAGAGACCT 5580

ACCTCAGGTT GCTGGTTGCT GTGTGGTTTG GTGTGTTCCC GCAAACCCCC TTTGTGCTGT 5640

GGGGCTGGTA GCTCAGGTGG GCGTGGTCAC TGCTGTCATC AGTTGAATGG TCAGCGTTGC 5700 ATGTCGTGAC CAACTAGACA TTCTGTCGCC TTAGCATGTT TGCTGAACAC CTTGTGGAAG 5760

CAAAAATCTG AAAATGTGAA TAAAATTATT TTGGATTTTG TAAAAAAAAA AAAAAAAAAA 5820 AAAAAAAAAA AAAAAAAA

Seq ID NO: 319 Protein sequence: Protein Accession ft: NP_005679

1 11 21 31 41 51 I I I I I I

MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL ETAARAEGLS 60

LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP VDNAGLFSCM TFSWLSSLAR 120

VAHKKGELSM EDVWSLSKHE SSDVNCRRLE RLWQEELNEV GPDAASLRRV VWIFCRTRLI 180 LSIVCLMITQ LAGPSGPAFM VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW 240 ALNYRTGVRL RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 300

PWAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA TDERVQKMNE 360

VLTYIKFIKM YAWVKAFSQS VQKIREEERR ILEKAGYFQG ITVGVAPIW VIASWTFSV 420

HMTLGFDLTA AQAFTWTVF NSMTFALKVT PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK 480

NKPASPHIKI EMKNATLAWD SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA 540 VLAEQKGHLL LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG 600

KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD EERYNSVLNS 660

CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY SDRSIYILDD PLSALDAHVG 720

NHIFNSAIRK HLKSKTVLFV THQLQYLVDC DEVIFMKEGC ITERGTHEEL MNLNGDYATI 780

FNNLLLGETP PVEINSKKET SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS 840 VPWSVYGVYI QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS 900

VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGWFVKGT LRASSRLHDE LFRRILRSPM 960

KPFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV FFCVGMIAGV FPWFLVAVGP 1020

LVILFSVLHI VSRVLIRELK RLDNITQSPF LSHITSSIQG LATIHAYNKG QEFLHRYQEL 1080

LDDNQAPFFL FTCAMRWLAV RLDLISIALI TTTGLMIVLM HGQIPPAYAG LAISYAVQLT 1140 GLFQFTVRLA SETEARFTSV ERINHYIKTL SLEAPARIKN KAPSPDWPQE GEVTFENAEM 1200

RYRENLPLVL KKVSFTIKPK EKIGIVGRTG SGKSSLGMAL FRLVELSGGC IKIDGVRISD 1260

IGLADLRSKL SIIPQEPVLF SGTVRSNLDP FNQYTEDQIW DALERTHMKE CIAQLPLKLE 1320

SEVMENGDNF SVGERQLLCI ARALLRHCKI LILDEATAAM DTETDLLIQE TIREAFADCT 1380

MLTIAHRLHT VLGSDRIMVL AQGQWEFDT PSVLLSNDSS RFYAMFAAAE NKVAVKG

Seq ID NO: 320 DNA sequence

Nucleic Acid Accession ft: AK022089.1

Coding sequence: 181-1488

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I I I I I I

AGCAGTTGCA CAACTTCCAG CAACTTTCTC AGCCGGCTAC TAATGAGCTG AAAGCCAGGA 60

ACATCCGAGG AGAAGAGAAA GCTTCCAGCC CTCCTCCCTT CACCCTGGAA ATCCAGACAC 120

CCCCACCCCC ACCCTCAGAT CACTTTAAGA TAATTTCTTT ATTCGTTTGC CCGACAGACC 180

ATGGCTCCCT TTGGAAGAAA CTTGCTAAAG ACTCGGCATA AAAACAGATC TCCAACTAAA 240

GACATGGATT CAGAAGAGAA GGAAATTGTG GTTTGGGTTT GCCAAGAAGA GAAGCTTGTC 300

TGTGGGCTGA CTAAACGCAC CACCTCTGCT GATGTCATCC AGGCTTTGCT TGAGGAACAT 360

GAGGCTACGT TTGGAGAGAA ACGATTTCTT CTGGGGAAGC CCAGTGATTA CTGCATCATA 420

GAGAAGTGGA GAGGCTCCGA AAGGGTTCTT CCTCCACTAA CTAGAATCCT GAAGCTTTGG 480

AAAGCGTGGG GAGATGAGCA GCCCAATATG CAATTTGTTT TGGTTAAAGC AGATGCTTTT 540

CTTCCAGTTC CTTTGTGGCG GACAGCTGAA GCCAAATTAG TGCAAAACAC AGAAAAATTG 600

TGGGAGCTCA GCCCAGCAAA CTACATGAAG ACTTTACCAC CAGATAAACA AAAAAGAATA 660

GTCAGGAAAA CTTTCCGGAA ACTGGCTAAA ATTAAGCAGG ACACAGTTTC TCATGATCGA 720

GATAATATGG AGACATTAGT TCATCTGATC ATTTCCCAGG ACCATACTAT TCATCAGCAA 780

GTCAAGAGAA TGAAAGAGCT GGATCTGGAA ATTGAAAAGT GTGAAGCTAA GTTCCATCTT 840

GATCGAGTAG AAAATGATGG AGAAAACTAT GTTCAGGATG CATATTTAAT GCCCAGTTTC 900

AGTGAAGTTG AGCAAAATCT AGACTTGCAG TATGAGGAAA ACCAGACTCT GGAGGACCTG 960

AGCGAAAGTG ATGGAATTGA ACAGCTGGAA GAACGACTGA AATATTACCG AATACTCATT 1020

GATAAGCTCT CTGCTGAAAT AGAAAAAGAG GTAAAAAGTG TTTGCATTGA TATAAATGAA 1080

GATGCGGAAG GGGAAGCTGC AAGTGAACTG GAAAGCTCTA ATTTAGAGAG TGTTAAGTGT 1140

GATTTGGAGA AAAGCATGAA AGCTGGTTTG AAAATTCACT CTCATTTGAG TGGCATCCAG 1200

AAAGAGATTA AATACAGTGA CTCATTGCTT CAGATGAAAG CAAAAGAATA TGAACTCCTG 1260

GCCAAGGAAT TCAATTCACT TCACATTAGC AACAAAGATG GGTGCCAGTT AAAGGAAAAC 1320

AGAGCGAAGG AATCTGAGGT TCCCAGTAGC AATGGGGAGA TTCCTCCCTT TACTCAAAGA 1380

GTATTTAGCA ATTACACAAA TGACACAGAC TCGGACACTG GTATCAGTTC TAACCACAGT 1440

CAGGACTCCG AAACAACAGT AGGAGATGTG GTGCTGTTGT CAACATAGTT CCAATGGCTC 1500

CTTTCTGACC TGCTTTCATG TTTTAATGTT TGTTTAATTT AATAGGAAAC CTCATTTTAA 1560

ATATAACACT CAAAAAAATG TAAATCATAT TGTAGTATTC AATAGTTAAT AAAAACTCGA 1620 GAAATGTGTT GTTTCTG

Seq ID NO: 321 Protein sequence: Protein Accession ft: NP_005438.1

1 11 21 31 41 51

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MAPFGRNLLK TRHKNRSPTK DMDSEEKEIV VWVCQEEKLV CGLTKRTTSA DVIQALLEEH 60

EATFGEKRFL LGKPSDYCII EKWRGSERVL PPLTRILKLW KAWGDEQPNM QFVLVKADAF 120

LPVPLWRTAE AKLVQNTEKL WELSPANYMK TLPPDKQKRI VRKTFRKLAK IKQDTVSHDR 180

DNMETLVHLI ISQDHTIHQQ VKRMKELDLE IEKCEAKFHL DRVENDGENY VQDAYLMPSF 240

SEVEQNLDLQ YEENQTLEDL SESDGIEQLE ERLKYYRILI DKLSAEIEKE VKSVCIDINE 300

DAEGEAASEL ESSNLESVKC DLEKSMKAGL KIHSHLSGIQ KEIKYSDSLL QMKAKEYELL 360

AKEFNSLHIS NKDGCQLKEN RAKESEVPSS NGEIPPFTQR VFSNYTNDTD SDTGISSNHS 420 QDSETTVGDV VLLST

Seq ID NO: 322 DNA sequence

Nucleic Acid Accession ft: NM_030920.1 Coding sequence: 317-1123

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I I I I I I

AGCATTGAAG GGGAAGGAAC TGCGGGTGTG GTGTGTGTAT GTGTGTGTGT ATGTGTGTGC 60

GGCGCGTGCG TGCGTGTGTG TGCGCGCGCT AGTGTGTGGA CAAGGAGGTG GGGGCAGCTG 120

AGTTAGAGTC CCAACTCTTG GACTCCATTT GCTATTCTCT TCTTTCTCCC CCACACCTAT 180

CTGGTGGTGG TAGTGGGCGT TTATATTTGC GTTCCTTTTC ATTCATTTCT AAATCTCTTA 240

AAAATTTTGG GTTGGGGGTA TTGGGGAAGG CAGGAAAGGG AAAAGGAGAG TAGTAGCTGA 300

AGAGCAAGAG GAGGACATGG AGATGAAGAA GAAGATTAAC CTGGAGTTAA GGAACAGATC 60

CCCGGAGGAG GTGACAGAGT TAGTCCTTGA TAATTGCCTG TGTGTCAATG GGGAAATTGA 420

AGGCCTGAAT GATACTTTCA AAGAACTAGA ATTTCTGAGT ATGGCTAATG TGGAACTAAG 480

TTCGCTGGCC CGGCTTCCCA GCTTAAATAA ACTTCGAAAA TTGGAGCTTA GTGATAATAT 540

AATTTCTGGA GGCTTGGAAG TCCTGGCAGA GAAATGTCCA AATCTTACCT ACCTCAATCT 600

GAGTGGAAAC AAAATAAAAG ATCTCAGTAC AGTAGAAGCT CTGCAAAATC TTAAAAATTT 660

GAAAAGTCTT GACCTGTTTA ACTGTGAGAT CACAAACCTG GAAGATTATA GAGAAAGTAT 720

TTTTGAACTA CTGCAGCAAA TCACATACTT AGATGGATTT GATCAGGAGG ATAATGAAGC 780

GCCGGACTCT GAAGAGGAGG ATGATGAGGA TGGAGATGAA GATGATGAAG AGGAAGAGGA 840

AAATGAAGCT GGTCCACCGG AAGGATATGA GGAAGAGGAG GAGGAAGAGG AAGAGGAGGA 900

TGAGGATGAG GATGAAGATG AAGATGAAGG AGGTTCAGAG TTGGGAGAGG GAGAAGAGGA 960

AGTGGGCCTC TCATACTTAA TGAAAGAAGA AATTCAGGAT GAAGAAGATG ATGATGACTA 1020

TGTTGAAGAA GGGGAAGAAG AGGAAGAAGA GGAAGAAGGA GGTCTTCGAG GGGAGAAGAG 1080

GAAACGAGAT GCTGAAGACG ATGGAGAGGA AGAAGATGAC TAGATCATTC TAAGACCAGA 1140

TTCTCTAATG TTTCTGGGTG TGCAATAGAG TGATCACATC TTTGTTTCTT CATGTACGAT 1200

AGCTATCCCT ACAGAAGATA ATGTGTAACT TTTTATAGGA AAAGTGTGGT TTTACTATTT 1260

TTGCCTTATC ATTCCAAATA AGAACTAGTC TGTTAATGAT CATATTGTAT GTAGAGAAAA 1320

ATTTTCATTG ACTCCCATTG TGGAATTCCC TAGCAATTTA TTTAGACTTA ATTTTTTAAA 1380

TTCAAGCTTA CTGTATTAGT CATTTTTAGC CCATAATTAA AACATGATCA CTTTTAAACA 1440

GGTGTAGTAT GGTGCATTTC ATTCCTTATT TATAGATTAA CTGAAATTAC AGTTTGCTAT 1500

AATATAAAAT GACAATAGTC TCTTGAGTGG TAAGTTGGTT ATTTTTTTAG AGGTGATCCA 1560

GGAATCTTTA GTTTGAAGGC AGTTACCTTT TTTTTTTTTT TTTTTTTTTG ACTAAGAGTG 1620

TTTGGTTGCT TTTTTGTCAC AAGTAACTTG GAAAATAGAA GCAGAATAGT AAAGGTTCTA 1680

TTCAGCAACA TAGTTCATGG ATTTTGTGGA GGTTCTATTC AGTAATATGG TTCATGGATT 1740

TAGTGGTGAC TGATAAGATT TTATTTTTGA AGGAAAAATT GCTTATACTA AGTCCAGAGA 1800

CATGCAGGTG AGCCCTTTTG TCAGGCTGCA AATCATGACA TGCCGATGGT TGTTTATTTT 1860

GTTTTTAGGT GTGCATTCTT TTTCTTCTTA GCAATTCCTT TATGATCACC TTCCCTTCTT 1920

GTTTCACTCC CTCCCGCTCT CTCAAAAGGA ACTTGGGAAA CTTGTGAAAC CCAGGAAAAC 1980

CTTTAGTCTT ATACCTCAAC TACGTTTCAG TCCTGTCTGG GTTTTAAATA AGTGAAGTAG 2040

AAGAAATTGA GTATTTTCTG ACATAAGAAT ATATTATCAA TACAGTTTTA TGCAGTAAGC 2100

TCTCCTTACC ATAAATGTTT CTTGGTTGAC AACATCTAAG ACAATATTAG TGGGATGAAG 2160

AAAGAAAAGC AGGGGTGCTT TTGGAAGCAG TGTTAGTGTT CCTCAAAAGT CGGAACAATT 2220

GCCTGTTGAT ATATTAATAA GACATTAAAG TCAAATTTTA ATGTTGGCCT CTCAAATGAT 2280

TTGGATACCA CTCTGCAAAG TATTTCTAAC CTTTAATTCC CAGTTTTAAA ACAGATATAA 2340

TAATAGCATT TAATTGGAAT ATACTAGGCA GCTGGAAAAG TATTTGAAAC TAAATTGACA 2400

TTAAAATTAA GATTTGTTTT CAAGTGGATG TCCATTAAAA GTAGAAAAAT ATTTGGGATA 2460

AGTGAGTGTG TGTTTCCTTA CATGGCTACT AAATAAAATA TAATGAGTAT ACAAGTATAT 2520

CTCCTCTTTT GCTATGGAGG CTCCATGTTC AAGGCAATGG CTTTTTAAAT CTTGGCTATC 2580

TAAAATTTTT TCCCTTTGTT TTGAATATTT GTAAGTTTTT AAGAAGTTAG TGTCAGCAAA 2640

TTAATTGAAG TTATGCTTCT ATACTGGGAC ATATTTAAAT ACTGAGTATA GTACTGCTGC 2700

TACTGCTTCT ACAATGTAAA ATGTATGACT TGGTGTTTTA AAGTAAAAAT TATGATGTTA 2760

CTTGTGGAGA AACTAAAAAT GTTGTACAAC TGACCGAAAG AAAACCCTTG GGGATAAGTT 2820

TAGTGAGGGG ATTGGAATCC CCAAAAAGAT AACATTTTTC TTCTGCTTTT AAAAACTGAA 2880

ATTCCCTGTT CTAGTTCCTA ACAATTCTCA TTACATACTA TGCCAGATTA CAAAATACTT 2940

ATTTTTAAAA TGAAATCTAT ATATTGACTT TCTTATCAAT CATCTTACTG TGCAATCAAA 3000

ATTAGAGTAC TTTGGTTTGA AAACAACACT TAGAGCCTCC AGATAACTTT TAAGACTTAT 3060

TTAGCTTTGT GGGTGGTATT TTCATGCAAA TAAGTAAGGG TGGGTTTTAT ATTTTGTAGA 3120

AGTTTTCGGT CCTATTTTAA TGCTCTTTGT ATGGCAGTAT GTATATATTG TGTTAAGTTC 3180

CTCAAGAATC TCCTTAAAAA CTTTGAAGTT AATACTTTTG TGCAACTGTG TTTTGAATAA 3240 AGCCATGACA GTGTTAAAAA CAAAC

Seq ID NO: 323 Protein sequence: Protein Accession ft: NP 112182.1 1 11 21 31 41 51 i i i i i i

MEMKKKINLE LRNRSPEEVT ELVLDNCLCV NGEIEGLNDT FKELEFLSMA NVELSSLARL 60

PSLNKLRKLE LSDNIISGGL EVLAEKCPNL TYLNLSGNKI KDLSTVEALQ NLKNLKSLDL 120

FNCEITNLED YRESIFELLQ QITYLDGFDQ EDNEAPDSEE EDDEDGDEDD EEEEENEAGP 180

PEGYEEEEEE EEEEDEDEDE DEDEAGSELG EGEEEVGLSY LMKEEIQDEE DDDDYVEEGE 240 EEEEEEEGGL RGEKRKRDAE DDGEEEDD

Seq ID NO: 324 DNA sequence Nucleic Acid Accession ft: NM_003812 Coding sequence: 224..2722

1 11 21 31 41 51

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TCCTCTGCGT CCCGCCCCGG GAGTGGCTGC GAGGCTAGGC GAGCCGGGAA AGGGGGCGCC 60

GCCCAGCCCC GAGCCCCGCG CCCCGTGCCC CGAGCCCGGA GCCCCCTGCC CGCGGCGGCA 120

CCATGCGCGC CGAGCCGGCG TGACCGGCTC CGCCCGCGGC CGCCCCGCAG CTAGCCCGGC 180

GCTCTCGCCG GCCACACGGA GCGGCGCCCG GGAGCTATGA GCCATGAAGC CGCCCGGCAG 240

CAGCTCGCGG CAGCCGCCCC TGGCGGGCTG CAGCCTTGCC GGCGCTTCCT GCGGCCCCCA 300

ACGCGGCCCC GCCGGCTCGG TGCCTGCCAG CGCCCCGGCC CGCACGCCGC CCTGCCGCCT 360

GCTTCTCGTC CTTCTCCTGC TGCCTCCGCT CGCCGCCTCG TCCCGGCCCC GCGCCTGGGG 420

GGCTGCTGCG CCCAGCGCTC CGCATTGGAA TGAAACTGCA GAAAAAAATT TGGGAGTCCT 480

GGCAGATGAA GACAATACAT TGCAACAGAA TAGCAGCAGT AATATCAGTT ACAGCAATGC 540

AATGCAGAAA GAAATCACAC TGCCTTCAAG ACTCATATAT TACATCAACC AAGACTCGGA 600 AAGCCCTTAT CACGTTCTTG ACACAAAGGC AAGACACCAG CAAAAACATA ATAAGGCTGT 660

CCATCTGGCC CAGGCAAGCT TCCAGATTGA AGCCTTCGGC TCCAAATTCA TTCTTGACCT 720

CATACTGAAC AATGGTTTGT TGTCTTCTGA TTATGTGGAG ATTCACTACG AAAATGGGAA 780

ACCACAGTAC TCTAAGGGTG GAGAGCACTG TTACTACCAT GGAAGCATCA GAGGCGTCAA 840 AGACTCCAAG GTGGCTCTGT CAACCTGCAA TGGACTTCAT GGCATGTTTG AAGATGATAC 900

CTTCGTGTAT ATGATAGAGC CACTAGAGCT GGTTCATGAT GAGAAAAGCA CAGGTCGACC 960

ACATATAATC CAGAAAACCT TGGCAGGACA GTATTCTAAG CAAATGAAGA ATCTCACTAT 1020

GGAAAGAGGT GACCAGTGGC CCTTTCTCTC TGAATTACAG TGGTTGAAAA GAAGGAAGAG 1080

AGCAGTGAAT CCATCACGTG GTATATTTGA AGAAATGAAA TATTTGGAAC TTATGATTGT 1140 TAATGATCAC AAAACGTATA AGAAGCATCG CTCTTCTCAT GCACATACCA ACAACTTTGC 1200

AAAGTCCGTG GTCAACCTTG TGGATTCTAT TTACAAGGAG CAGCTCAACA CCAGGGTTGT 1260

CCTGGTGGCT GTAGAGACCT GGACTGAGAA GGATCAGATT GACATCACCA CCAACCCTGT 1320

GCAGATGCTC CATGAGTTCT CAAAATACCG GCAGCGCATT AAGCAGCATG CTGATGCTGT 1380

GCACCTCATC TCGCGGGTGA CATTTCACTA TAAGAGAAGC AGTCTGAGTT ACTTTGGAGG 1440 TGTCTGTTCT CGCACAAGAG GAGTTGGTGT GAATGAGTAT GGTCTTCCAA TGGCAGTGGC 1500

ACAAGTATTA TCGCAGAGCC TGGCTCAAAA CCTTGGAATC CAATGGGAAC CTTCTAGCAG 1560

AAAGCCAAAA TGTGACTGCA CAGAATCCTG GGGTGGCTGC ATCATGGAGG AAACAGGGGT 1620

GTCCCATTCT CGAAAATTTT CAAAGTGCAG CATTTTGGAG TATAGAGACT TTTTACAGAG 1680

AGGAGGTGGA GCCTGCCTTT TCAACAGGCC AACAAAGCTA TTTGAGCCCA CGGAATGTGG 1740 AAATGGATAC GTGGAAGCTG GGGAGGAGTG TGATTGTGGT TTTCATGTGG AATGCTATGG 1800

ATTATGCTGT AAGAAATGTT CCCTCTCCAA CGGGGCTCAC TGCAGCGACG GGCCCTGCTG 1860

TAACAATACC TCATGTCTTT TTCAGCCACG AGGGTATGAA TGCCGGGATG CTGTGAACGA 1920

GTGTGATATT ACTGAATATT GTACTGGAGA CTCTGGTCAG TGCCCACCAA ATCTTCATAA 1980

GCAAGACGGA TATGCATGCA ATCAAAATCA GGGCCGCTGC TACAATGGCG AGTGCAAGAC 2040 CAGAGACAAC CAGTGTCAGT ACATCTGGGG AACAAAGGGT GCAGGGTCTG ACAAGTTCTG 2100

CTATGAAAAG CTGAATACAG AAGGCACTGA GAAGGGAAAC TGCGGGAAGG ATGGAGACCG 2160

GTGGATTCAG TGCAGCAAAC ATGATGTGTT CTGTGGATTC TTACTCTGTA CCAATCTTAC 2220

TCGAGCTCCA CGTATTGGTC AACTTCAGGG TGAGATCATT CCAACTTCCT TCTACCATCA 2280

AGGCCGGGTG ATTGACTGCA GTGGTGCCCA TGTAGTTTTA GATGATGATA CGGATGTGGG 2340 CTATGTAGAA GATGGAACGC CATGTGGCCC GTCTATGATG TGTTTAGATC GGAAGTGCCT 2400

ACAAATTCAA GCCCTAAATA TGAGCAGCTG TCCACTCGAT TCCAAGGGTA AAGTCTGTTC 2460

GGGCCATGGG GTGTGTAGTA ATGAAGCCAC CTGCATTTGT GATTTCACCT GGGCAGGGAC 2520

AGATTGCAGT ATCCGGGATC CAGTTAGGAA CCTTCACCCC CCCAAGGATG AAGGACCCAA 2580

GGGTCCTAGT GCCACCAATC TCATAATAGG CTCCATCGCT GGTGCCATCC TGGTAGCAGC 2640 TATTGTCCTT GGGGGCACAG GCTGGGGATT TAAAAATGTC AAGAAGAGAA GGTTCGATCC 2700

TACTCAGCAA GGCCCCATCT GAATCAGCTG CGCTGGATGG ACACCGCCTT GCACTGTTGG 2760

ATTCTGGGTA TGACATACTC GCAGCAGTGT TACTGGAACT ATTAAGTTTG TAAACAAAAC 2820

CTTTGGGTGG TAATGACTAC GGAGCTAAAβ TTGGGGTGAC AAGGATGGGG TAAAAGAAAA 2880

CTGTCTCTTT TGGAAATAAT GTCAAAGAAC ACCTTTCACC ACCTGTCAGT AAACGGGGGA 2940 GGGGGCAAAA GACCATGCTA TAAAAAGAAC TGTTCCAGAA TCTTTTTTTT TCCCTAATGG 3000 ACGAAGGAAC AACACACACA CAAAAATTAA ATGCAATAAA GGAATCATTA AAAA

Seq ID NO: 325 Protein sequence: Protein Accession ft: NP 003803

11 21 31 41 51

I I I I I

MKPPGSSSRQ PPLAGCSLAG ASCGPQRGPA GSVPASAPAR TPPCRLLLVL LLLPPLAASS 60 RPRAWGAAAP SAPHWNETAE KNLGVLADED NTLQQNSSSN ISYSNAMQKE ITLPSRLIYY 120 INQDSESPYH VLDTKARHQQ KHNKAVHLAQ ASFQIEAFGS KFILDLILNN GLLSSDYVEI 180 HYENGKPQYS KGGEHCYYHG SIRGVKDSKV ALSTCNGLHG MFEDDTFVYM IEPLELVHDE 240 KSTGRPHIIQ KTLAGQYSKQ MKNLTMERGD QWPFLSELQW LKRRKRAVNP SRGIFEEMKY 300 LELMIVNDHK TYKKHRSSHA HTNNFAKSW NLVDSIYKEQ LNTRWLVAV ETWTEKDQID 360 ITTNPVQMLH EFSKYRQRIK QHADAVHLIS RVTFHYKRSS LSYFGGVCSR TRGVGVNEYG 420 LPMAVAQVLS QSLAQNLGIQ WEPSSRKPKC DCTESWGGCI MEETGVSHSR KFSKCSILEY 480 RDFLQRGGGA CLFNRPTKLF EPTECGNGYV EAGEECDCGF HVECYGLCCK KCSLSNGAHC 540 SDGPCCNNTS CLFQPRGYEC RDAVNECDIT EYCTGDSGQC PPNLHKQDGY ACNQNQGRCY 600 NGECKTRDNQ CQYIWGTKAA GSDKFCYEKL NTEGTEKGNC GKDGDRWIQC SKHDVFCGFL 660 LCTNLTRAPR IGQLQGEIIP TSFYHQGRVI DCSGAHWLD DDTDVGYVED GTPCGPSMMC 720 LDRKCLQIQA LNMSSCPLDS KGKVCSGHGV CSNEATCICD FTWAGTDCSI RDPVRNLHPP 780 KDEGPKGPSA TNLIIGSIAG AILVAAIVLG GTGWGFKNVK KRRFDPTQQG PI

Seq ID NO: 326 DNA sequence Nucleic Acid Accession ft: AK074418.1 Coding sequence: 244-1515

11 21 31 41 51

CTTTCTCCAA GACGGCCGGC CATGCTCTCC TCCTCTGCCA GTCTCCTCCA CCACTCTCTA 60 ACCTGAGAGC CTGTGGAACC TGCCCGTCTC CCCTCCTCCA TCAGACACAC CTGCCTAGGA 120 AACAGATGGA AAAAGTGAGG GACCGGTGAG TGACTTGCTG CTAAAGTTTA TACCAGATGC 180 AAATGACAGA GCTGGAGTTC TGCTGTGCCT GGAAAGGACC TCGGAAGTCT TCTAAGGAGA 240 GTCATGGCGT ATTACCAGGA GCCTTCAGTG GAGACCTCCA TCATCAAGTT CAAAGACCAG 300 GACTTTACCA CCTTGCGGGA TCACTGCCTG AGCATGGGCC GGACGTTTAA GGATGAGACA 360 TTCCCCGCAG CAGATTCTTC CATAGGCCAG AAGCTGCTCC AGGAAAAACG CCTCTCCAAT 420 GTGATATGGA AGCGGCCACA GGATCTACCA GGGGGTCCTC CTCACTTCAT CCTGGATGAT 480 ATAAGCAGAT TTGACATCCA ACAAGGAGGC GCAGCTGACT GCTGGTTCCT GGCAGCACTG 540 GGATCCTTGA CTCAGAACCC ACAGTACAGG CAGAAGATCC TGATGGTCCA AAGCTTTTCA 600 CACCAGTATG CTGGCATTTT CCGTTTCCGG TTCTGGCAAT GTGGCCAGTG GGTGGAAGTG 660 GTGATTGATG ACCGCCTACC TCTCCAGGGA GATAAATGCC TCTTTGTGCG TCCTCGCCAC 720 CAAAACCAAG AGTTCTGGCC CTGCCTGCTG GAGAAGGCCT ATGCCAAGCT GCTCGGATCC 780 TATTCCGATC TGCAGTATGG CTTCCTCGAG GATGCCCTGG TGGACCTCAC AGGAGGCGTG 840 ATCACCAACA TCCATCTGCA CTCTTCCCCT GTGGACCTGG TGAAGGCAGT GAAGACAGCG 900 ACCAAGGCAG GCTCCCTGAT AACCTGTGCC ACTCCAAGTG GGCCAACAGA TACAGCACAG 960 GCGATGGAGA ATGGGCTGGT GAGTCTCCAT GCCTACACTG TGACTGGGGC TGAGCAGATT 1020 CAATACCGAA GGGGCTGGGA AGAAATTATC TCCCTGTGGA ACCCCTGGGG CTGGGGCGAG 1080 ACCGAATGGA GAGGGCGCTG GAGTGATGGG TCTCAGGAGT GGGAGGAAAC CTGTGATCCG 1140 CGGAAAAGCC AGCTACATAA GAAACGGGAA GATGGCGAGT TTTGGATGTC GTGTCAAGAT 1200

TTCCAACAGA AATTCATCGC CATGTTTATA TGTAGCGAAA TTCCAATTAC CCTGGACCAT 1260

GGAAACACAC TCCACGAAGG ATGGTCCCAA ATAATGTTTA GGAAGCAAGT GATTCTAGGA 1320

AACACTGCAG GAGGACCTCG GAATGATGCT CAATTCAACT TCTCTGTGCA AGAGCCAATG 1380

GAAGGCACCA ATGTTGTCGT GTGCGTCACA GTTGCTGTCA CACCATCAAA TTTGAAAGCA 1440

GAAGATGCAA AATTTCCACT CGATTTCCAA GTGATTCTGG CTGGCTCACA GAAACACTGT 1500

CCAAAGCTCA AATAATAAAT TCCGCCGCAA CTTCACCATG ACTTACCATC TGAGCCCTGG 1560

GAACTATGTT GTGGTTGCAC AGACACGGAG AAAATCAGCG GAGTTCTTGC TCCGAATCTT 1620

CCTGAAAATG CCAGACAGTG ACAGGCACCT GAGCAGCCAT TTCAACCTCA GAATGAAGGG 1680

AAGCCCTTCA GAACATGGCT CCCAACAAAG CATTTTCAAC AGATATGCTC AGCAGGTATG 1740

GTACCTAGCA CCCAGGGGCC TTACGTGGGA TTGGAGAAAG GGGACCTGAG GGAGGGACAG 1800

CCCTCACAGG CCCTTACTGG GATGCAGAGA GGAGAAGTGA CTTGATGGAC TATTTTACCT 1860

GCCTCTCTTC CTGGATCGTC TCCAGAACTG CTGTGGCTGC CAAGCTCGGT AGAGACGTGG 1920

CGCCCCACCC AGTCTCATCC GGGGGACTTC AAGCTGGAAT GCAGAGCTTA GAAAGGGAGG 1980

GGATAATTAT GGGGTGTGAG GTGCATTGCC CTCTAAATCT TTAAACAAGC AATTGGCAGT 2040

ACCCCGTGAA ACCTTTCCTT CTCCTACTCG GCCACCTCCC ACCAACCTGG CATCGTTCCT 2100

CCCGGGAGCT AGCCAGCTTC AGAAAGCACA TACAGCATCC TTGCTGCCAA ACCACCTATG 2160

TGCACACAGG ATTTCCTTAA TGGCTTAATA AACTGTTATA AAGAACTCCT TGACTTGTCA 2220

GAATAAAATA GCTGCCAGGG GCTCTGCACA ATGAGCCTCT TACCGTTAAA AAAAAAAAAA 2280 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA

Seq ID NO: 327 Protein sequence: Protein Accession ft: BAB85075.1

51

MAYYQEPSVE TSIIKFKDQD FTTLRDHCLS MGRTFKDETF PAADSSIGQK LLQEKRLSNV 60

IWKRPQDLPG GPPHFILDDI SRFDIQQGGA ADCWFLAALG SLTQNPQYRQ KILMVQSFSH 120

QYAGIFRFRF WQCGQWVEW IDDRLPVQGD KCLFVRPRHQ NQEFWPCLLE KAYAKLLGSY 180

SDLHYGFLED ALVDLTGGVI TNIHLHSSPV DLVKAVKTAT KAGSLITCAT PSGPTDTAQA 240

MENGLVSLHA YTVTGAEQIQ YRRGWEEIIS LWNPWGWGET EWRGRWSDGS QEWEETCDPR 300

KSQLHKKRED GEFWMSCQDF QQKFIAMFIC SEIPITLDHG NTLHEGWSQI MFRKQVILGN 360

TAGGPRNDAQ FNFSVQEPME GTNVWCVTV AVTPSNLKAE DAKFPLDFQV ILAGSQKHCP 420

Seq ID NO: 328 DNA sequence

Nucleic Acid Accession ft: BC017490.1

Coding sequence: 74-2788

11 21 31 41 51

I I I I I

GTGGGTCACG TGAACCACTT TTCGCGCGAA ACCTGGTTGT TGCTGTAGTG GCGGAGAGGA 60 TCGTGGTACT GCTATGGCGG AATCATCGGA ATCCTTCACC ATGGCATCCA GCCCGGCCCA 120 GCGTCGGCGA GGCAATGATC CTCTCACCTC CAGCCCTGGC CGAAGCTCCC GGCGTACTGA 180 TGCCCTCACC TCCAGCCCTG GCCGTGACCT TCCACCATTT GAGGATGAGT CCGAGGGGCT 240 CCTAGGCACA GAGGGGCCCC TGGAGGAAGA AGAGGATGGA GAGGAGCTCA TTGGAGATGG 300 CATGGAAAGG GACTACCGCG CCATCCCAGA GCTGGACGCC TATGAGGCCG AGGGACTGGC 360 TCTGGATGAT GAGGACGTAG AGGAGCTGAC GGCCAGTCAG AGGGAGGCAG CAGAGCGGGC 420 CATGCGGCAG CGTGACCGGG AGGCTGGCCG GGGCCTGGGC CGCATGCGCC GTGGGCTCCT 480 GTATGACAGC GATGAGGAGG ACGAGGAGCG CCCTGCCCGC AAGCGCCGCC AGGTGGAGCG 540 GGCCACGGAG GACGGCGAGG AGGACGAGGA GATGATCGAG AGCATCGAGA ACCTGGAGGA 600 TCTCAAAGGC CACTCTGTGC GCGAGTGGGT GAGCATGGCG GGCCCCCGGC TGGAGATCCA 660 CCACCGCTTC AAGAACTTCC TGCGCACTCA CGTCGACAGC CACGGCCACA ACGTCTTCAA 720 GGAGCGCATC AGCGACATGT GCAAAGAGAA CCGTGAGAGC CTGGTGGTGA ACTATGAGGA 780 CTTGGCAGCC AGGGAGCACG TGCTGGCCTA CTTCCTGCCT GAGGCACCGG CGGAGCTGCT 840 GCAGATCTTT GATGAGGCTG CCCTGGAGGT GGTACTGGCC ATGTACCCCA AGTACGACCG 900 CATCACCAAC CACATCCATG TCCGCATCTC CCACCTGCCT CTGGTGGAGG AGCTGCGCTC 960 GCTGAGGCAG CTGCATCTGA ACCAGCTGAT CCGCACCAGT GGGGTGGTGA CCAGCTGCAC 1020 TGGCGTCCTG CCCCAGCTCA GCATGGTCAA GTACAACTGC AACAAGTGCA ATTTCGTCCT 1080 GGGTCCTTTC TGCCAGTCCC AGAACCAGGA GGTGAAACCA GGCTCCTGTC CTGAGTGCCA 1140 GTCGGCCGGC CCCTTTGAGG TCAACATGGA GGAGACCATC TATCAGAACT ACCAGCGTAT 1200 CCGAATCCAG GAGAGTCCAG GCAAAGTGGC GGCTGGCCGG CTGCCCCGCT CCAAGGACGC 1260 CATTCTCCTC GCAGATCTGG TGGACAGCTG CAAGCCAGGA GACGAGATAG AGCTGACTGG 1320 CATCTATCAC AACAACTATG ATGGGTCCCT CAACACTGCC AATGGCTTCC CTGTCTTTGC 1380 CACTGTCATC CTAGCCAACC ACGTGGCCAA GAAGGACAAC AAGGTTGCTG TAGGGGAACT 1440 GACCGATGAA GATGTGAAGA TGATCACTAG CCTCTCCAAG GATCAGCAGA TCGGAGAGAA 1500 GATCTTTGCC AGCATTGCTC CTTCCATCTA TGGTCATGAA GACATCAAGA GAGGCCTGGC 1560 TCTGGCCCTG TTCGGAGGGG AGCCCAAAAA CCCAGGTGGC AAGCACAAGG TACGTGGTGA 1620 TATCAACGTG CTCTTGTGCG GAGACCCTGG CACAGCGAAG TCGCAGTTTC TCAAGTATAT 1680 TGAGAAAGTG TCCAGCCGAG CCATCTTCAC CACTGGCCAG GGGGCGTCGG CTGTGGGCCT 1740 CACGGCGTAT GTCCAGCGGC ACCCTGTCAG CAGGGAGTGG ACCTTGGAGG CTGGGGCCCT 1800 GGTTCTGGCT GACCGAGGAG TGTGTCTCAT TGATGAATTT GACAAGATGA ATGACCAGGA 1860 CAGAACCAGC ATCCATGAGG CCATGGAGCA ACAGAGCATC TCCATCTCGA AGGCTGGCAT 1920 CGTCACCTCC CTGCAGGCTC GCTGCACGGT CATTGCTGCC GCCAACCCCA TAGGAGGGCG 1980 CTACGACCCC TCGCTGACTT TCTCTGAGAA CGTGGACCTC ACAGAGCCCA TCATCTCACG 2040 CTTTGACATC CTGTGTGTGG TGAGGGACAC CGTGGACCCA GTCCAGGACG AGATGCTGGC 2100 CCGCTTCGTG GTGGGCAGCC ACGTCAGACA CCACCCCAGC AACAAGGAGG AGGAGGGGCT 2160 GGCCAATGGC AGCGCTGCTG AGCCCGCCAT GCCCAACACG TATGGCGTGG AGCCCCTGCC 2220 CCAGGAGGTC CTGAAGAAGT ACATCATCTA CGCCAAGGAG AGGGTCCACC CGAAGCTCAA 2280 CCAGATGGAC CAGGACAAGG TGGCCAAGAT GTACAGTGAC CTGAGGAAAG AATCTATGGC 2340 GACAGGCAGC ATCCCCATTA CGGTGCGGCA CATCGAGTCC ATGATCCGCA TGGCGGAGGC 2400 CCACGCGCGC ATCCATCTGC GGGACTATGT GATCGAAGAC GACGTCAACA TGGCCATCCG 2460 CGTGATGCTG GAGAGCTTCA TAGACACACA GAAGTTCAGC GTCATGCGCA GCATGCGCAA 2520 GACTTTTGCC CGCTACCTTT CATTCCGGCG TGACAACAAT GAGCTGTTGC TCTTCATACT 2580 GAAGCAGTTA GTGGCAGAGC AGGTGACATA TCAGCGCAAC CGCTTTGGGG CCCAGCAGGA 2640 CACTATTGAG GTCCCTGAGA AGGACTTGGT GGATAAGGCT CGTCAGATCA ACATCCACAA 2700 CCTCTCTGCA TTTTATGACA GTGAGCTCTT CAGGATGAAC AAGTTCAGCC ACGACCTGAA 2760

AAGGAAAATG ATCCTGCAGC AGTTCTGAGG CCCTATGCCA TCCATAAGGA TTCCTTGGGA 2820

TTCTGGTTTG GGGTGGTCAG TGCCCTCTGT GCTTTATGGA CACAAAACCA GAGCACTTGA 2880

TGAACTCGGG GTACTAGGGT CAGGGCTTAT AGCAGGATGT CTGGCTGCAC CTGGCATGAC 2940

TGTTTGTTTC TCCAAGCCTG CTTTGTGCTT CTCACCTTTG GGTGGGATGC CTTGCCAGTG 3000

TGTCTTACTT GGTTGCTGAA CATCTTGCCA CCTCCGAGTG CTTTGTCTCC ACTCAGTACC 3060

TTGGATCAGA GCTGCTGAGT TCAGGATGCC TGCGTGTGGT TTAGGTGTTA GCCTTCTTAC 3120

ATGGATGTCA GGAGAGCTGC TGCCCTCTTG GCGTGAGTTG CGTATTCAGG CTGCTTTTGC 3180

TGCCTTTGGC CAGAGAGCTG GTTGAAGATG TTTGTAATCG TTTTCAGTCT CCTGCAGGTT 3240

TCTGTGCCCC TGTGGTGGAA GAGGGCACGA CAGTGCCAGC GCAGCGTTCT GGGCTCCTCA 3300

GTCGCAGGGG TGGGATGTGA GTCATGCGGA TTATCCACTC GCCACAGTTA TCAGCTGCCA 3360

TTGCTCCCTG TCTGTTTCCC CACTCTCTTA TTTGTGCATT CGGTTTGGTT TCTGTAGTTT 3420 TAATTTTTAA TAAAGTTGAA TAAAATATAA AAAAAAAAAA AAAAAA

Seq ID NO: 329 Protein sequence: Protein Accession ft: AAH17490.1

11 21 31 41 51

I I I I

MAESSESFTM ASSPAQRRRG NDPLTSSPGR SSRRTDALTS SPGRDLPPFE DESEGLLGTE 60 GPLEEEEDGE ELIGDGMERD YRAIPELDAY EAEGLALDDE DVEELTASQR EAAERAMRQR 120 DREAGRGLGR MRRGLLYDSD EEDEERPARK RRQVERATED GEEDEEMIES IENLEDLKGH 180 SVREWVSMAG PRLEIHHRFK NFLRTHVDSH GHNVFKERIS DMCKENRESL WNYEDLAAR 240 EHVLAYFLPE APAELL IFD EAALEWLAM YPKYDRITNH IHVRISHLPL VEELRSLRQL 300 HLNQLIRTSG WTSCTGVLP QLSMVKYNCN KCNFVLGPFC QSQNQEVKPG SCPECQSAGP 360 FEVNMEETIY QNYQRIRIQE SPGKVAAGRL PRSKDAILLA DLVDSCKPGD EIELTGIYHN 420 NYDGSLNTAN GFPVFATVIL ANHVAKKDNK VAVGELTDED VKMITSLSKD QQIGEKIFAS 480 IAPSIYGHED IKRGLALALF GGEPKNPGGK HKVRGDINVL LCGDPGTAKS QFLKYIEKVS 540 SRAIFTTGQG ASAVGLTAYV QRHPVSREWT LEAGALVLAD RGVCLIDEFD KMNDQDRTSI 600 HEAMEQQSIS ISKAGIVTSL QARCTVIAAA NPIGGRYDPS LTFSENVDLT EPIISRFDIL 660 CWRDTVDPV QDEMLARFW GSHVRHHPSN KEEEGLANGS AAEPAMPNTY GVEPLPQEVL 720 KKYIIYAKER VHPKLNQMDQ DKVAKMYSDL RKESMATGSI PITVRHIESM IRMAEAHARI 780 HLRDYVIEDD VNMAIRVMLE SFIDTQKFSV MRSMRKTFAR YLSFRRDNNE LLLFILKQLV 840 AEQVTYQRNR FGAQQDTIEV PEKDLVDKAR QINIHNLSAF YDSELFRMNK FSHDLKRKMI 900 LQQF

Seq ID NO: 330 DNA sequence Nucleic Acid Accession ft: M17254 Coding sequence: 257-1645

11 21 31 41 51

GTCCGCGCGT GTCCGCGCCC GCGTGTGCCA GCGCGCGTGC CTTGGCCGTG CGCGCCGAGC 60 CGGGTCGCAC TAACTCCCTC GGCGCCGACG GCGGCGCTAA CCTCTCGGTT ATTCCAGGAT 120 CTTTGGAGAC CCGAGGAAAG CCGTGTTGAC CAAAAGCAAG ACAAATGACT CACAGAGAAA 180 AAAGATGGCA GAACCAAGGG CAACTAAAGC CGTCAGGTTC TGAACAGCTG GTAGATGGGC 240 TGGCTTACTG AAGGACATGA TTCAGACTGT CCCGGACCCA GCAGCTCATA TCAAGGAAGC 300 CTTATCAGTT GTGAGTGAGG ACCAGTCGTT GTTTGAGTGT GCCTACGGAA CGCCACACCT 360 GGCTAAGACA GAGATGACCG CGTCCTCCTC CAGCGACTAT GGACAGACTT CCAAGATGAG 420 CCCACGCGTC CCTCAGCAGG ATTGGCTGTC TCAACCCCCA GCCAGGGTCA CCATCAAAAT 480 GGAATGTAAC CCTAGCCAGG TGAATGGCTC AAGGAACTCT CCTGATGAAT GCAGTGTGGC 540 CAAAGGCGGG AAGATGGTGG GCAGCCCAGA CACCGTTGGG ATGAACTACG GCAGCTACAT 600 GGAGGAGAAG CACATGCCAC CCCCAAACAT GACCACGAAC GAGCGCAGAG TTATCGTGCC 660 AGCAGATCCT ACGCTATGGA GTACAGACCA TGTGCGGCAG TGGCTGGAGT GGGCGGTGAA 720 AGAATATGGC CTTCCAGACG TCAACATCTT GTTATTCCAG AACATCGATG GGAAGGAACT 780 GTGCAAGATG ACCAAGGACG ACTTCCAGAG GCTCACCCCC AGCTACAACG CCGACATCCT 840 TCTCTCACAT CTCCACTACC TCAGAGAGAC TCCTCTTCCA CATTTGACTT CAGATGATGT 900 TGATAAAGCC TTACAAAACT CTCCACGGTT AATGCATGCT AGAAACACAG ATTTACCATA 960 TGAGCCCCCC AGGAGATCAG CCTGGACCGG TCACGGCCAC CCCACGCCCC AGTCGAAAGC 1020 TGCTCAACCA TCTCCTTCCA CAGTGCCCAA AACTGAAGAC CAGCCTCCTC AGTTAGATCC 1080 TTATCAGATT CTTGGACCAA CAAGTAGCCβ CCTTGCAAAT CCAGGCAGTG GCCAGATCCA 1140 GCTTTGGCAG TTCCTCCTGG AGCTCCTGTC GGACAGCTCC AACTCCAGCT GCATCACCTG 1200 GGAAGGCACC AACGGGGAGT TCAAGATGAC GGATCCCGAC GAGGTGGCCC GGCGCTGGGG 1260 AGAGCGGAAG AGCAAACCCA ACATGAACTA CGATAAGCTC AGCCGCGCCC TCCGTTACTA 1320 CTATGACAAG AACATCATGA CCAAGGTCCA TGGGAAGCGC TACGCCTACA AGTTCGACTT 1380 CCACGGGATC GCCCAGGCCC TCCAGCCCCA CCCCCCGGAG TCATCTCTGT ACAAGTACCC 1440 CTCAGACCTC CCGTACATGG GCTCCTATCA CGCCCACCCA CAGAAGATGA ACTTTGTGGC 1500 GCCCCACCCT CCAGCCCTCC CCGTGACATC TTCCAGTTTT TTTGCTGCCC CAAACCCATA 1560 CTGGAATTCA CCAACTGGGG GTATATACCC CAACACTAGG CTCCCCACCA GCCATATGCC 1620 TTCTCATCTG GGCACTTACT ACTAAAGACC TGGCGGAGGC TTTTCCCATC AGCGTGCATT 1680 CACCAGCCCA TCGCCACAAA CTCTATCGGA GAACATGAAT CAAAAGTGCC TCAAGAGGAA 1740 TGAAAAAAGC TTTACTGGGG CTGGGGAAGG AAGCCGGGGA AGAGATCCAA AGACTCTTGG 1800 GAGGGAGTTA CTGAAGTCTT ACTACAGAAA TGAGGAGGAT GCTAAAAATG TCACGAATAT 1860 GGACATATCA TCTGTGGACT GACCTTGTAA AAGACAGTGT ATGTAGAAGC ATGAAGTCTT 1920 AAGGACAAAG TGCCAAAGAA AGTGGTCTTA AGAAATGTAT AAACTTTAGA GTAGAGTTTG 1980 AATCCCACTA ATGCAAACTG GGATGAAACT AAAGCAATAG AAACAACACA GTTTTGACCT 2040 AACATACCGT TTATAATGCC ATTTTAAGGA AAACTACCTG TATTTAAAAA TAGTTTCATA 2100 TCAAAAACAA GAGAAAAGAC ACGAGAGAGA CTGTGGCCCA TCAACAGACG TTGATATGCA 2160 ACTGCATGGC ATGTGCTGTT TTGGTTGAAA TCAAATACAT TCCGTTTGAT GGACAGCTGT 2220 CAGCTTTCTC AAACTGTGAA GATGACCCAA AGTTTCCAAC TCCTTTACAG TATTACCGGG 2280 ACTATGAACT AAAAGGTGGG ACTGAGGATG TGTATAGAGT GAGCGTGTGA TTGTAGACAG 2340 AGGGGTGAAG AAGGAGGAGG AAGAGGCAGA GAAGGAGGAG ACCAGGCTGG GAAAGAAACT 2400 TCTCAAGCAA TGAAGACTGG ACTCAGGACA TTTGGGGACT GTGTACAATG AGTTATGGAG 2460 ACTCGAGGGT TCATGCAGTC AGTGTTATAC CAAACCCAGT GTTAGGAGAA AGGACACAGC 2520 GTAATGGAGA AAGGGAAGTA GTAGAATTCA GAAACAAAAA TGCGCATCTC TTTCTTTGTT 2580 TGTCAAATGA AAATTTTAAC TGGAATTGTC TGATATTTAA GAGAAACATT CAGGACCTCA 2640 TCATTATGTG GGGGCTTTGT TCTCCACAGG GTCAGGTAAG AGATGGCCTT CTTGGCTGCC 2700 ACAATCAGAA ATCACGCAGG CATTTTGGGT AGGCGGCCTC CAGTTTTCCT TTGAGTCGCG 2760

AACGCTGTGC GTTTGTCAGA ATGAAGTATA CAAGTCAATG TTTTTCCCCC TTTTTATATA 2820

ATAATTATAT AACTTATGCA TTTATACACT ACGAGTTGAT CTCGGCCAGC CAAAGACACA 2880

CGACAAAAGA GACAATCGAT ATAATGTGGC CTTGAATTTT AACTCTGTAT GCTTAATGTT 2940

TACAATATGA AGTTATTAGT TCTTAGAATG CAGAATGTAT GTAATAAAAT AAGCTTGGCC 3000

TAGCATGGCA AATCAGATTT ATACAGGAGT CTGCATTTGC ACTTTTTTTA GTGACTAAAG 3060

TTGCTTAATG AAAACATGTG CTGAATGTTG TGGATTTTGT GTTATAATTT ACTTTGTCCA 3120 GGAACTTGTG CAAGGGAGAG CCAAGGAAAT AGGATGTTTG GCACCC

Seq ID NO: 331 Protein sequence Protein Accession ft: AAA52398

1 11 21 31 41 51

I I I I I I

MIQTVPDPAA HIKEALSWS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ TSKMSPRVPQ 60

QDWLSQPPAR VTIKMECNPS QVNGSRNSPD ECSVAKGGKM VGSPDTVGMN YGSYMEEKHM 120

PPPNMTTNER RVIVPADPTL WSTDHVRQWL EWAVKEYGLP DVNILLFQNI DGKELCKMTK 180

DDFQRLTPSY NADILLSHLH YLRETPLPHL TSDDVDKALQ NSPRLMHARN TDLPYEPPRR 240

SAWTGHGHPT PQSKAAQPSP STVPKTEDQR PQLDPYQILG PTSSRLANPG SGQIQLWQFL 300

LELLSDSSNS SCITWEGTNG EFKMTDPDEV ARRWGERKSK PNMNYDKLSR ALRYYYDKNI 360

MTKVHGKRYA YKFDFHGIAQ ALQPHPPESS LYKYPSDLPY MGSYHAHPQK MNFVAPHPPA 420

LPVTSSSFFA APNPYWNSPT GGIYPNTRLP TSHMPSHLGT YY 462

Seq ID NO: 332 DNA sequence Nucleic Acid Accession ft: NM_000020 Coding sequence: 283-1794

1 11 21 31 41 51

I I I I I I

AGGAAACGGT TTATTAGGAG GGAGTGGTGG AGCTGGGCCA GGCAGGAAGA CGCTGGAATA 60

AGAAACATTT TTGCTCCAGC CCCCATCCCA GTCCCGGGAG GCTGCCGCGC CAGCTGCGCC 120

GAGCGAGCCC CTCCCCGGCT CCAGCCCGGT CCGGGGCCGC GCCGGACCCC AGCCCGCCGT 180

CCAGCGCTGG CGGTGCAACT GCGGCCGCGC GGTGGAGGGG AGGTGGCCCC GGTCCGCCGA 240

AGGCTAGCGC CCCGCCACCC GCAGAGCGGG CCCAGAGGGA CCATGACCTT GGGCTCCCCC 300

AGGAAAGGCC TTCTGATGCT GCTGATGGCC TTGGTGACCC AGGGAGACCC TGTGAAGCCG 360

TCTCGGGGCC CGCTGGTGAC CTGCACGTGT GAGAGCCCAC ATTGCAAGGG GCCTACCTGC 420

CGGGGGGCCT GGTGCACAGT AGTGCTGGTG CGGGAGGAGG GGAGGCACCC CCAGGAACAT 480

CGGGGCTGCG GGAACTTGCA CAGGGAGCTC TGCAGGGGGC GCCCCACCGA GTTCGTCAAC 540

CACTACTGCT GCGACAGCCA CCTCTGCAAC CACAACGTGT CCCTGGTGCT GGAGGCCACC 600

CAACCTCCTT CGGAGCAGCC GGGAACAGAT GGCCAGCTGG CCCTGATCCT GGGCCCCGTG 660

CTGGCCTTGC TGGCCCTGGT GGCCCTGGGT GTCCTGGGCC TGTGGCATGT CCGACGGAGG 720

CAGGAGAAGC AGCGTGGCCT GCACAGCGAG CTGGGAGAGT CCAGTCTCAT CCTGAAAGCA 780

TCTGAGCAGG GCGACACGAT GTTGGGGGAC CTCCTGGACA GTGACTGCAC CACAGGGAGT 840

GGCTCAGGGC TCCCCTTCCT GGTGCAGAGG ACAGTGGCAC GGCAGGTTGC CTTGGTGGAG 900

TGTGTGGGAA AAGGCCGCTA TGGCGAAGTG TGGCGGGGCT TGTGGCACGG TGAGAGTGTG 960

GCCGTCAAGA TCTTCTCCTC GAGGGATGAA CAGTCCTGGT TCCGGGAGAC TGAGATCTAT 1020

AACACAGTAT TGCTCAGACA CGACAACATC CTAGGCTTCA TCGCCTCAGA CATGACCTCC 1080

CGCAACTCGA GCACGCAGCT GTGGCTCATC ACGCACTACC ACGAGCACGG CTCCCTCTAC 1140

GACTTTCTGC AGAGACAGAC GCTGGAGCCC CATCTGGCTC TGAGGCTAGC TGTGTCCGCG 1200

GCATGCGGCC TGGCGCACCT GCACGTGGAG ATCTTCGGTA CACAGGGCAA ACCAGCCATT 1260

GCCCACCGCG ACTTCAAGAG CCGCAATGTG CTGGTCAAGA GCAACCTGCA GTGTTGCATC 1320

GCCGACCTGG GCCTGGCTGT GATGCACTCA CAGGGCAGCG ATTACCTGGA CATCGGCAAC 1380

AACCCGAGAG TGGGCACCAA GCGGTACATG GCACCCGAGG TGCTGGACGA GCAGATCCGC 1440

ACGGACTGCT TTGAGTCCTA CAAGTGGACT GACATCTGGG CCTTTGGCCT GGTGCTGTGG 1500

GAGATTGCCC GCCGGACCAT CGTGAATGGC ATCGTGGAGG ACTATAGACC ACCCTTCTAT 1560

GATGTGGTGC CCAATGACCC CAGCTTTGAG GACATGAAGA AGGTGGTGTG TGTGGATCAG 1620

CAGACCCCCA CCATCCCTAA CCGGCTGGCT GCAGACCCGG TCCTCTCAGG CCTAGCTCAG 1680

ATGATGCGGG AGTGCTGGTA CCCAAACCCC TCTGCCCGAC TCACCGCGCT GCGGATCAAG 1740

AAGACACTAC AAAAAATTAG CAACAGTCCA GAGAAGCCTA AAGTGATTCA ATAGCCCAGG 1800

AGCACCTGAT TCCTTTCTGC CTGCAGGGGG CTGGGGGGGT GGGGGGCAGT GGATGGTGCC 1860

CTATCTGGGT AGAGGTAGTG TGAGTGTGGT GTGTGCTGGG GATGGGCAGC TGCGCCTGCC 1920

TGCTCGGCCC CCAGCCCACC CAGCCAAAAA TACAGCTGGG CTGAAACCTG ATCCCCTGCT 1980

GTCTGGCCTG CTCAAAGCGG CAGGCTCCCT GACGCCTGGC TCTCTCCCCA CCCCTATGGC 2040

CAGCATGGTG CACCCCCTAC CACTCCCGGG ACAGGATGCA AAAGAGGCTC CAGAGTCAGA 2100

GTGCCAAGCC AGGGAATCCC AGTCCCAGAC TCAGAGCCCG GGCCTGCACT TTGCCCCCTG 2160

CCCTTGATCA ACCCCACTGC CCCACCAGAG CTGCCAGGGT GGCACAGGGC CCTGTCCAGC 2220

CCCTGGCACA CACTTCCCTG CCAGGCCTCA GCCTCTAGCA TAAGCTCCAG AGAGCCAGGG 2280

CCCATCAGTT TCTCTCTGTG GATTTGTATC TCAGCTCCAT GATGCCTTGG GCTTTCTGTC 2340

TCCTCAACAA GAGTGCAGCT TGCTGAATGT CAGCTGCCTG AGAGAGCTGG GGCCTGACTT 2400

ACTAGGGCAT TAAATCCTAA GAGGTCCTAC TGAGGTGTGG CAGGATCACA GGCCAGTGGA 2460

AAAAGGGCAG GTCAGATGGG CAAGGCCCAG GACTTTCAGA TTAACTGAGA GGATATCGAG 2520

GCCAAGCATG GCAGGGGGAA GGTCAGTGGG TGTCAAGAGA CCCAGGTCTG ACCCCGGATG 2580

TTTGCTCCAT GTGACAAAAG CAGGCCTGTC TCAGGACCTT TTCTTTTCTT TTTTCCTTCT 2640

TTTTTTTTTT GACACGGAGT TTCGCTCTTG TTGTCCAGGC TAGAGTGCAA TGGCATGATC 2700

CCAGCTCACC GCAACGTCTA CCTCCCAGGT TCAAATCATT CTCTTGCCTC AGACTCCCGA 2760

GTAGCTGGGA TTACAGGCAC ATGCCACCAT GCCTGGCTAA TTTTGTATAT TTAGTAGAAA 2820

CAGGGTTTCA CCATGCTGGC CATGCTGGTT CTCGAACTCC TGACCTCAGG TGTTCCACCT 2880

ACCTCAGCCT CCCAAAGTGC TGGGGTTACA GGTGTGAGCC ATCGCGCCTG GCCAGGACCT 2940

TTGTTTCTTA TCTACATATT GGAAGATTTG GTCCTGATGT CCTTTGAGGC TTCTTTAGCT 3000

CTAGTTCTCT GACACTTCAG CCTATATCAC AGCTAACTTC YTCAGTCTCA TCTATTCCTT 3060

ATGCTCCAGC CCCTGGCAAT TTGCCTCAAG ATGGGGGTTT GAAAATAACT TTACCTGACT 3120

CAAGGAGTGT CTGGAGCACC TCCTAGTCTA AGTCTGCAAG CTCCAGTTCT TGCCTAAAAC 3180

CATGCCAGTG GCCACCCTTG GGCTCAGACA GCTCTGGGCC TTTTGACCAC AAGCCAGCCC 3240

CTCGCCCTCT CTGTGGCATA GTCTTCTCTG GCCCAGGACT GCAGGGCGGC TTCCTCCAAG 3300

GCTTCCAAGG CTCAAAAGAA ATTTGGCTCC ATCCAAGAAG GCTCCAGCTC CCCTACTGGC 3360

CCCTGGCTTC AGGCCCACAC CCCTGGGCCA GGSCCAGAGA GTGTGTCTCA GGAGAATTCA 3420

ATGGGCTCTA GAGAGACACA CAGAAAGTTT GGGCATTTGG GAAATTTTCA AGGRTGTATG 3480 TATGGYTCAC GTATGGWGCA GGTTGTCCTG GTCCYKGGGT GCAGGGAAGT GGGCTGCAGG 3540

GAAGTGGATT GGAGGGGAGC TTGAGGAATA TAAGGAGCGG GGGTGGAGAC TCAGGCTATG 3600

GACAAGGACA GCCCCAAGGT TGGGAAGACC TGGCCTTAGT CGTCCTCAGC CTAGGGCAGG 3660

GCAGTGAAGA AAGCTCTCCC CGCTCCTGCT GTAATGACCC AGAGTAGCCT CCCCAGGCCG 3720

GCATCTTATG TGTGTCTTCC ACCATCCTCA TGGTGGCACT TTTCTAGGCC TGTCTCCCAG 3780

CATTGTGCAA GGCTCGGAAG AGAACCAGGA AGTGAAACTG GGTGAAAACA GAAAGCTCAA 3840

TGGATGGGCT AGGTTCCCAG ATCATTAGGG CAGAGTTTGC ACGTCCTCTG GTTCACTGGG 3900

AATCCACCCA GCCCACGAAT CATCTCCCTC TTTGAAGGAT TTTWATTTCT ACTGGGTTTT 3960

GGAACAAACT CCTGCTGAGA CCCCACAGCC AGAAACTGAA AGCAGCAGCT CCCCAAAGCC 4020

10 TGGAAAATCC CTAAGAGAAG GCCTGGGGGA MAGGAAKTGG AGTGACAGGG GACAGGTAGA 4080

GAGAAGGGGG CCCAATGGCC AGGGAGTGAA GGAGGTGGCG TTGCTGAGAG CAGTCTGCAC 4140

ATGCTTCTGT CTGAGTGCAG GAAGGTGTTC CAGGGTCGAA ATTACACTTC TCGTACCTGG 4200

AGACGCTGTT TGTGGGAGCA CTGGGCTCAT GCCTGGCACA CAATAGGTCT GCAATAAACC 4260 ATGGTTAAAT CCTGAAAAAA AAAAAAAAA

15

Seq ID NO: 333 Protein sequence Protein Accession ft: NP 000011

20 1 11 21 31 41 51

M ITLGSPRKGL LIMLLMALVTQ GIDPVKPSRGP LIVTCTCESPH CIKGPTCRGAW CITWLVREEG 60

RHPQEHRGCG NLHRELCRGR PTEFVNHYCC DSHLCNHNVS LVLEATQPPS EQPGTDGQLA 120

LILGPVLALL ALVALGVLGL WHVRRRQEKQ RGLHSELGES SLILKASEQG DTMLGDLLDS 180

25 DCTTGSGSGL PFLVQRTVAR QVALVECVGK GRYGEVWRGL WHGESVAVKI FSSRDEQSWF 240

RETEIYNTVL LRHDNILGFI ASDMTSRNSS TQLWLITHYH EHGSLYDFLQ RQTLEPHLAL 300

RLAVSAACGL AHLHVEIFGT QGKPAIAHRD FKSRNVLVKS NLQCCIADLG LAVMHSQGSD 360

YLDIGNNPRV GTKRYMAPEV LDEQIRTDCF ESYKWTDIWA FGLVLWEIAR RTIVNGIVED 420

YRPPFYDWP NDPSFEDMKK WCVDQQTPT IPNRLAADPV LSGLAQMMRE CWYPNPSARL 480

30 TALRIKKTLQ KISNSPEKPK VIQ

Seq ID NO: 334 DNA sequence

Nucleic Acid Accession ft: NM_004126.1

Coding sequence: 108-329

35

1 11 21 31 41 51

I I I I I I

GGCACGAGCT CGTGCCGGCC TTCAGTTGTT TCGGGACGCG CCGAGCTTCG CCGCTCTTCC 60

AGCGGCTCCG CTGCCAGAGC TAGCCCGAGC CCGGTTCTGG GGCGAAAATG CCTGCCCTTC 120

40 ACATCGAAGA TTTGCCAGAG AAGGAAAAAC TGAAAATGGA AGTTGAGCAG CTTCGCAAAG 180

AAGTGAAGTT GCAGAGACAA CAAGTGTCTA AATGTTCTGA AGAAATAAAG AACTATATTG 240

AAGAACGTTC TGGAGAGGAT CCTCTAGTAA AGGGAATTCC AGAAGACAAG AACCCCTTTA 300

AAGAAAAAGG CAGCTGTGTT ATTTCATAAA TAACTTGGGA GAAACTGCAT CCTAAGTGGA 360

AGAACTAGTT TGTTTTAGTT TTCCCAGATA AAACCAACAT GCTTTTTAAG GAAGGAAGAA 420

45 TGAAATTAAA AGGAGACTTT CTTAAGCACC ATATAGATAG GGTTATGTAT AAAAGCATAT 480

GTGCTACTCA TCTTTGCTCA CTATGCAGTC TTTTTTAAGA GAGCAGAGAG TATCAGATGT 540

ACAATTATGG AAATAAGAAC ATTACTTGAG CATGACACTT CTTTCAGTAT ATTGCTTGAT 600 GCTTCAAATA AAGTTTTGTC TT

50 Seq ID NO: 335 Protein sequence Protein Accession ft: NP_004117.1

1 11 21 31 41 51

55 I I I I I I

MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE DPLVKGIPED 60

KNPFKEKGSC VIS

Seq ID NO : 336 DNA sequence 60 Nucleic Acid Accession ft : NM_005795

Coding sequence : 555 -1940

1 11 21 31 41 51

_ΛC I I I I I I

OD GCACGAGGGA ACAACCTCTG TCTCTSCAGC AGAGAGTGTC ACCTCCTGCT TTAGGACCAT 60

CAAGCTCTGC TAACTGAATC TCATCCTAAT TGCAGGATCA CATTGCAAAG CTTTCACTCT 120

TTCCCACCTT GCTTGTGGGT AAATCTCTTC TGCGGAATCT CAGAAAGTAA AGTTCCATCC 180

TGAGAATATT TCACAAAGAA TTTCCTTAAG AGCTGGACTG GGTCTTGACC CCTGGAATTT 240

AAGAAATTCT TAAAGACAAT GTCAAATATG ATCCAAGAGA AAATGTGATT TGAGTCTGGA 300

70 GACAATTGTG CATATCGTCT AATAATAAAA ACCCATACTA GCCTATAGAA AACAATATTT 360

GAATAATAAA AACCCATACT AGCCTATAGA AAACAATATT TGAAAGATTG CTACCACTAA 420

AAAGAAAACT ACTACAACTT GACAAGACTG CTGCAAACTT CAATTGGTCA CCACAACTTG 480

ACAAGGTTGC TATAAAACAA GATTGCTACA ACTTCTAGTT TATGTTATAC AGCATATTTC 540

ATTTGGGCTT AATGATGGAG AAAAAGTGTA CCCTGTATTT TCTGGTTCTC TTGCCTTTTT 600

75 TTATGATTCT TGTTACAGCA GAATTAGAAG AGAGTCCTGA GGACTCAATT CAGTTGGGAG 660

TTACTAGAAA TAAAATCATG ACAGCTCAAT ATGAATGTTA CCAAAAGATT ATGCAAGACC 720

CCATTCAACA AGCAGAAGGC GTTTACTGCA ACAGAACCTG GGATGGATGG CTCTGCTGGA 780

ACGATGTTGC AGCAGGAACT GAATCAATGC AGCTCTGCCC TGATTACTTT CAGGACTTTG 840

ATCCATCAGA AAAAGTTACA AAGATCTGTG ACCAAGATGG AAACTGGTTT AGACATCCAG 900

80 CAAGCAACAG AACATGGACA AATTATACCC AGTGTAATGT TAACACCCAC GAGAAAGTGA 960

AGACTGCACT AAATTTGTTT TACCTGACCA TAATTGGACA CGGATTGTCT ATTGCATCAC 1020

TGCTTATCTC GCTTGGCATA TTCTTTTATT TCAAGAGCCT AAGTTGCCAA AGGATTACCT 1080

TACACAAAAA TCTGTTCTTC TCATTTGTTT GTAACTCTGT TGTAACAATC ATTCACCTCA 1140

CTGCAGTGGC CAACAACCAG GCCTTAGTAG CCACAAATCC TGTTAGTTGC AAAGTGTCCC 1200

85 AGTTCATTCA TCTTTACCTG ATGGGCTGTA ATTACTTTTG GATGCTCTGT GAAGGCATTT 1260

ACCTACACAC ACTCATTGTG GTGGCCGTGT TTGCAGAGAA GCAACATTTA ATGTGGTATT 1320

ATTTTCTTGG CTGGGGATTT CCACTGATTC CTGCTTGTAT ACATGCCATT GCTAGAAGCT 1380 TATATTACAA TGACAATTGC TGGATCAGTT CTGATACCCA TCTCCTCTAC ATTATCCATG 1440

GCCCAATTTG TGCTGCTTTA CTGGTGAATC TTTTTTTCTT GTTAAATATT GTACGCGTTC 1500

TCATCACCAA GTTAAAAGTT ACACACCAAG CGGAATCCAA TCTGTACATG AAAGCTGTGA 1560

GAGCTACTCT TATCTTGGTG CCATTGCTTG GCATTGAATT TGTGCTGATT CCATGGCGAC 1620

CTGAAGGAAA GATTGCAGAG GAGGTATATG ACTACATCAT GCACATCCTT ATGCACTTCC 1680

AGGGTCTTTT GGTCTCTACC ATTTTCTGCT TCTTTAATGG AGAGGTTCAA GCAATTCTGA 1740

GAAGAAACTG GAATCAATAC AAAATCCAAT TTGGAAACAG CTTTTCCAAC TCAGAAGCTC 1800

TTCGTAGTGC GTCTTACACA GTGTCAACAA TCAGTGATGG TCCAGGTTAT AGTCATGACT 1860

GTCCTAGTGA ACACTTAAAT GGAAAAAGCA TCCATGATAT TGAAAATGTT CTCTTAAAAC 1920

10 CAGAAAATTT ATATAATTGA AAATAGAAGG ATGGTTGTCT CACTGTTTGG TGCTTCTCCT 1980

AACTCAAGGA CTTGGACCCA TGACTCTGTA GCCAGAAGAC TTCAATATTA AATGACTTTG 2040

GGGAATGTCA TAAAGAAGAG CCTTCACATG AAATTAGTAG TGTGTTGATA AGAGTGTAAC 2100

ATCCAGCTCT ATGTGGGAAA AAAGAAATCC TGGTTTGTAA TGTTTGTCAG TAAATACTCC 2160

CACTATGCCT GATGTGACGC TACTAACCTG ACATCACCAA GTGTGGAATT GGAGAAAAGC 2220

15 ACAATCAACT TTTCTGAGCT GGTGTAAGCC AGTTCCAGCA CACCATTGAT GAATTCAAAC 2280

AAATGGCTGT AAAACTAAAC ATACATGTTG GGCATGATTC TACCCTTATT CSCCCCAAGA 2340

GACCTAGCTA AGGTCTATAA ACATGAAGGG AAAATTAGCT TTTAGTTTTA AAACTCTTTA 2400

TCCCATCTTG ATTGGGGCAG TTGACTTTTT TTTTTTCCCA GAGTGCCGTA GTCCTTTTTG 2460

TAACTACCCT CTCAAATGGA CAATACCAGA AGTGAATTAT CCCTGCTGGC TTTCTTTTCT 2520

20 CTATGAAAAG CAACTGAGTA CAATTGTTAT GATCTACTCA TTTGCTGACA CATCAGTTAT 2580

ATCTTGTGGC ATATCCATTG TGGAAACTGG ATGAACAGGA TGTATAATAT GCAATCTTAC 2640

TTCTATATGA TTAGGAAAAC ATCTTAGTTG ATGCTACAAA ACACCTTGTC AACCTCTTCC 2700

TGTCTTACCA AACAGTGGGA GGGAATTCCT AGCTGTAAAT ATAAATTTTG CCCTTCCATT 2760

TCTACTGTAT AAACAAATTA GCAATCATTT TATATAAAGA AAATCAATGA AGGATTTCTT 2820

25 ATTTTCTTGG AATTTTGTAA AAAGAAATTG TGAAAAATGA GCTTGTAAAT ACTCCATTAT 2880

TTTATTTTAT AGTCTCAAAT CAAATACATA CAACCTATGT AATTTTTAAA GCAAATATAT 2940

AATGCAACAA TGTGTGTATG TTAATATCTG ATACTGTATC TGGGCTGATT TTTTAAATAA 3000 AATAGAGTCT GGAATGCT

30 Seq ID NO: 337 protein sequence

Protein Accession ft: NP_005786.1

1 11 21 31 41 51

- I I I I I I

JJ MEKKCTLYFL VLLPFFMILV TAELEESPED SIQLGVTRNK IMTAQYECYQ KIMQDPIQQA 60

EGVYCNRTWD GWLCWNDVAA GTESMQLCPD YFQDFDPSEK VTKICDQDGN WFRHPASNRT 120

WTNYTQCNVN THEKVKTALN LFYLTIIGHG LSIASLLISL GIFFYFKSLS CQRITLHKNL 180

FFSFVCNSW TIIHLTAVAN NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL 240

IWAVFAEKQ HLMWYYFLGW GFPLIPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA 300

40 ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV LIPWRPEGKI 360

AEEVYDYIMH ILMHFQGLLV STIFCFFNGE VQAILRRNWN QYKIQFGNSF SNSEALRSAS 420

YTVSTISDGP GYSHDCPSEH LNGKSIHDIE NVLLKPENLY N

Seq ID NO: 338 DNA sequence

45 Nucleic Acid Accession ft: NM_001795 Coding sequence: 25-2379

1 11 21 31 41 51

50 G ICACGATCTG TITCCTCCTGG GIAAGATGCAG AIGGCTCATGA TIGCTCCTCGC CIACATCGGGC 60

GCCTGCCTGG GCCTGCTGGC AGTGGCAGCA GTGGCAGCAG CAGGTGCTAA CCCTGCCCAA 120

CGGGACACCC ACAGCCTGCT GCCCACCCAC CGGCGCCAAA AGAGAGATTG GATTTGGAAC 180

CAGATGCACA TTGATGAAGA GAAAAACACC TCACTTCCCC ATCATGTAGG CAAGATCAAG 240

TCAAGCGTGA GTCGCAAGAA TGCCAAGTAC CTGCTCAAAG GAGAATATGT GGGCAAGGTC 300

55 TTCCGGGTCG ATGCAGAGAC AGGAGACGTG TTCGCCATTG AGAGGCTGGA CCGGGAGAAT 360

ATCTCAGAGT ACCACCTCAC TGCTGTCATT GTGGACAAGG ACACTGGTGA AAACCTGGAG 420

ACTCCTTCCA GCTTCACCAT CAAAGTTCAT GACGTGAACG ACAACTGGCC TGTGTTCACG 480

CATCGGTTGT TCAATGCGTC CGTGCCTGAG TCGTCGGCTG TGGGGACCTC AGTCATCTCT 540

GTGACAGCAG TGGATGCAGA CGACCCCACT GTGGGAGACC ACGCCTCTGT CATGTACCAA 600

60 ATCCTGAAGG GGAAAGAGTA TTTTGCCATC GATAATTCTG GACGTATTAT CACAATAACG 660

AAAAGCTTGG ACCGAGAGAA GCAGGCCAGG TATGAGATCG TGGTGGAAGC GCGAGATGCC 720

CAGGGCCTCC GGGGGGACTC GGGCACGGCC ACCGTGCTGG TCACTCTGCA AGACATCAAT 780

GACAACTTCC CCTTCTTCAC CCAGACCAAG TACACATTTG TCGTGCCTGA AGACACCCGT 840

GTGGGCACCT CTGTGGGCTC TCTGTTTGTT GAGGACCCAG ATGAGCCCCA GAACCGGATG 900

65 ACCAAGTACA GCATCTTGCG GGGCGACTAC CAGGACGCTT TCACCATTGA GACAAACCCC 960

GCCCACAACG AGGGCATCAT CAAGCCCATG AAGCCTCTGG ATTATGAATA CATCCAGCAA 1020

TACAGCTTCA TCGTCGAGGC CACAGACCCC ACCATCGACC TCCGATACAT GAGCCCTCCC 1080

GCGGGAAACA GAGCCCAGGT CATTATCAAC ATCACAGATG TGGACGAGCC CCCCATTTTC 1140

CAGCAGCCTT TCTACCACTT CCAGCTGAAG GAAAACCAGA AGAAGCCTCT GATTGGCACA 1200

70 GTGCTGGCCA TGGACCCTGA TGCGGCTAGG CATAGCATTG GATACTCCAT CCGCAGGACC 1260

AGTGACAAGG GCCAGTTCTT CCGAGTCACA AAAAAGGGGG ACATTTACAA TGAGAAAGAA 1320

CTGGACAGAG AAGTCTACCC CTGGTATAAC CTGACTGTGG AGGCCAAAGA ACTGGATTCC 1380

ACTGGAACCC CCACAGGAAA AGAATCCATT GTGCAAGTCC ACATTGAAGT TTTGGATGAG 1440

AATGACAATG CCCCGGAGTT TGCCAAGCCC TACCAGCCCA AAGTGTGTGA GAACGCTGTC 1500

75 CATGGCCAGC TGGTCCTGCA GATCTCCGCA ATAGACAAGG ACATAACACC ACGAAACGTG 1560

AAGTTCAAAT TCACCTTGAA TACTGAGAAC AACTTTACCC TCACGGATAA TCACGATAAC 1620

ACGGCCAACA TCACAGTCAA GTATGGGCAG TTTGACCGGG AGCATACCAA GGTCCACTTC 1680

CTACCCGTGG TCATCTCAGA CAATGGGATG CCAAGTCGCA CGGGCACCAG CACGCTGACC 1740

GTGGCCGTGT GCAAGTGCAA CGAGCAGGGC GAGTTCACCT TCTGCGAGGA TATGGCCGCC 1800

80 CAGGTGGGCG TGAGCATCCA GGCAGTGGTA GCCATCTTAC TCTGCATCCT CACCATCACA 1860

GTGATCACCC TGCTCATCTT CCTGCGGCGG CGGCTCCGGA AGCAGGCCCG CGCGCACGGC 1920

AAGAGCGTGC CGGAGATCCA CGAGCAGCTG GTCACCTACG ACGAGGAGGG CGGCGGCGAG 1980

ATGGACACCA CCAGCTACGA TGTGTCGGTG CTCAACTCGG TGCGCCGCGG CGGGGCCAAG 2040

CCCCCGCGGC CCGCGCTGGA CGCCCGGCCT TCCCTCTATG CGCAGGTGCA GAAGCCACCG 2100

85 AGGCACGCGC CTGGGGCACA CGGAGGGCCC GGGGAGATGG CAGCCATGAT CGAGGTGAAG 2160

AAGGACGAGG CGGACCACGA CGGCGACGGC CCCCCCTACG ACACGCTGCA CATCTACGGC 2220

TACGAGGGCT CCGAGTCCAT AGCCGAGTCC CTCAGCTCCC TGGGCACCGA CTCATCCGAC 2280 TCTGACGTGG ATTACGACTT CCTTAACGAC TGGGGACCCA GGTTTAAGAT GCTGGCTGAG 2340

CTGTACGGCT CGGACCCCCG GGAGGAGCTG CTGTATTAGG CGGCCGAGGT CACTCTGGGC 2400

CTGGGGACCC AAACCCCCTG CAGCCCAGGC CAGTCAGACT CCAGGCACCA CAGCCTCCAA 2460

AAATGGCAGT GACTCCCCAG CCCAGCACCC CTTCCTCGTG GGTCCCAGAG ACCTCATCAG 2520

CCTTGGGATA GCAAACTCCA GGTTCCTGAA ATATCCAGGA ATATATGTCA GTGATGACTA 2580

TTCTCAAATG CTGGCAAATC CAGGCTGGTG TTCTGTCTGG GCTCAGACAT CCACATAACC 2640

CTGTCACCCA CAGACCGCCG TCTAACTCAA AGACTTCCTC TGGCTCCCCA AGGCTGCAAA 2700

GCAAAACAGA CTGTGTTTAA CTGCTGCAGG GTCTTTTTCT AGGGTCCCTG AACGCCCTGG 2760

TAAGGCTGGT GAGGTCCTGG TGCCTATCTG CCTGGAGGCA AAGGCCTGGA CAGCTTGACT 2820

TGTGGGGCAG GATTCTCTGC AGCCCATTCC CAAGGGAGAC TGACCATCAT GCCCTCTCTC 2880

GGGAGCCCTA GCCCTGCTCC AACTCCATAC TCCACTCCAA GTGCCCCACC ACTCCCCAAC 2940

CCCTCTCCAG GCCTGTCAAG AGGGAGGAAG GGGCCCCATG GCAGCTCCTG^" ACCTTGGGTC 3000

CTGAAGTGAC CTCACTGGCC TGCCATGCCA GTAACTGTGC TGTACTGAGC ACTGAACCAC 3060

ATTCAGGGAA ATGCTTATTA AACCTTGAAG CAACTGTGAA TTCATTCTGG AGGGGCAGTG 3120

GAGATCAGGA GTGACAGATC ACAGGGTGAG GGCCACCTCC ACACCCACCC CCTCTGGAGA 3180

AGGCCTGGAA GAGCTGAGAC CTTGCTTTGA GACTCCTCAG CACCCCTCCA GTTTTGCCTG 3240

AGAAGGGGCA GATGTTCCCG GAGATCAGAA GACGTCTCCC CTTCTCTGCC TCACCTGGTC 3300

GCCAATCCAT GCTCTCTTTC TTTTCTCTGT CTACTCCTTA TCCCTTGGTT TAGAGGAACC 3360

CAAGATGTGG CCTTTAGCAA AACTGACAAT GTCCAAACCC ACTCATGACT GCATGACGGA 3420

GCCGAGCATG TGTCTTTACA CCTCGCTGTT GTCACATCTC AGGGAACTGA CCCTCAGGCA 3480

CACCTTGCAG AAGGAAGGCC CTGCCCTGCC CAACCTCTGT GGTCACCCAT GCATCATTCC 3540

ACTGGAACGT TTCACTGCAA ACACACCTTG GAGAAGTGGC ATCAGTCAAC AGAGAGGGGC 3600

AGGGAAGGAG ACACCAAGCT CACCCTTCGT CATGGACCGA GGTTCCCACT CTGGCAAAGC 3660

CCCTCACACT GCAAGGGATT GTAGATAACA CTGACTTGTT TGTTTTAACC AATAACTAGC 3720

TTCTTATAAT GATTTTTTTA CTAATGATAC TTACAAGTTT CTAGCTCTCA CAGACATATA 3780

GAATAAGGGT TTTTGCATAA TAAGCAGGTT GTTATTTAGG TTAACAATAT TAATTCAGGT 3840

TTTTTAGTTG GAAAAACAAT TCCTGTAACC TTCTATTTTC TATAATTGTA GTAATTGCTC 3900

TACAGATAAT GTCTATATAT TGGCCAAACT GGTGCATGAC AAGTACTGTA TTTTTTTATA 3960 CCTAAATAAA GAAAAATCTT TAGCCTGGGC AACAAAAAAA

Seq ID NO: 339 Protein sequence Protein Accession ft: NP 001786

11 21 31 41 51

I I I I

MQRLMMLLAT SGACLGLLAV AAVAAAGANP AQRDTHSLLP THRRQKRDWI WNQMHIDEEK 60 NTSLPHHVGK IKSSVSRKNA KYLLKGEYVG KVFRVDAETG DVFAIERLDR ENISEYHLTA 120 VIVDKDTGEN LETPSSFTIK VHDVNDNWPV FTHRLFNASV PESSAVGTSV ISVTAVDADD 180 PTVGDHASVM YQILKGKEYF AIDNSGRIIT ITKSLDREKQ ARYEIWEAR DAQGLRGDSG 240 TATVLVTLQD INDNFPFFTQ TKYTFWPED TRVGTSVGSL FVEDPDEPQN RMTKYSI RG 300 DYQDAFTIET NPAHNEGIIK PMKPLDYEYI QQYSFIVEAT DPTIDLRYMS PPAGNRAQVI 360 INITDVDEPP IFQQPFYHFQ LKENQKKPLI GTVLAMDPDA ARHSIGYSIR RTSDKGQFFR 420 VTKKGDIYNE KELDREVYPW YNLTVEAKEL DSTGTPTGKE SIVQVHIEVL DENDNAPEFA 480 KPYQPKVCEN AVHGQLVLQI SAIDKDITPR NVKFKFTLNT ENNFTLTDNH DNTANITVKY 540 GQFDREHTKV HFLPWISDN GMPSRTGTST LTVAVCKCNE QGEFTFCEDM AAQVGVSIQA 600 WAILLCILT ITVITLLIFL RRRLRKQARA HGKSVPEIHE QLVTYDEEGG GEMDTTSYDV 660 SVLNSVRRGG AKPPRPALDA RPSLYAQVQK PPRHAPGAHG GPGEMAAMIE VKKDEADHDG 720 DGPPYDTLHI YGYEGSESIA ESLSSLGTDS SDSDVDYDFL NDWGPRFKML AELYGSDPRE 780 ELLY

Seq ID NO: 340 DNA sequence Nucleic Acid Accession ft: NM_003088 Coding sequence: 112-1593

11 21 31 41 51

GCGGAGGGTG CGTGCGGGCC GCGGCAGCCG AACAAAGGAG CAGGGGCGCC GCCGCAGGGA 60 CCCGCCACCC ACCTCCCGGG GCCGCGCAGC GGCCTCTCGT CTACTGCCAC CATGACCGCC 120 AACGGCACAG CCGAGGCGGT GCAGATCCAG TTCGGCCTCA TCAACTGCGG CAACAAGTAC 180 CTGACGGCCG AGGCGTTCGG GTTCAAGGTG AACGCGTCCG CCAGCAGCCT GAAGAAGAAG 240 CAGATCTGGA CGCTGGAGCA GCCCCCTGAC GAGGCGGGCA GCGCGGCCGT GTGCCTGCGC 300 AGCCACCTGG GCCGCTACCT GGCGGCGGAC AAGGACGGCA ACGTGACCTG CGAGCGCGAG 360 GTGCCCGGTC CCGACTGCCG TTTCCTCATC GTGGCGCACG ACGACGGTCG CTGGTCGCTG 420 CAGTCCGAGG CGCACCGGCG CTACTTCGGC GGCACCGAGG ACCGCCTGTC CTGCTTCGCG 480 CAGACGGTGT CCCCCGCCGA GAAGTGGAGC GTGCACATCG CCATGCACCC TCAGGTCAAC ^• 540 ATCTACAGTG TCACCCGTAA GCGCTACGCG CACCTGAGCG CGCGGCCGGC CGACGAGATC 600 GCCGTGGACC GCGACGTGCC CTGGGGCGTC GACTCGCTCA TCACCCTCGC CTTCCAGGAC 660 CAGCGCTACA GCGTGCAGAC CGCCGACCAC CGCTTCCTGC GCCACGACGG GCGCCTGGTG 720 GCGCGCCCCG AGCCGGCCAC TGGCTACACG CTGGAGTTCC GCTCCGGCAA GGTGGCCTTC 780 CGCGACTGCG AGGGCCGTTA CCTGGGGCCG TCGGGGCCCA GCGGCACGCT CAAGGCGGGC 840 AAGGCCACCA AGGTGGGCAA GGACGAGCTC TTTGCTCTGG AGCAGAGCTG CGCCCAGGTC 900 GTGCTGCAGG CGGCCAACGA GAGGAACGTG TCCACGCGCC AGGGTATGGA CCTGTCTGCC 960 AATCAGGACG AGGAGACCGA CCAGGAGACC TTCCAGCTGG AGATCGACCG CGACACCAAA 1020 AAGTGTGCCT TCCGTACCCA CACGGGCAAG TACTGGACGC TGACGGCCAC CGGGGGCGTG 1080 CAGTCCACCG CCTCCAGCAA GAATGCCAGC TGCTACTTTG ACATCGAGTG GCGTGACCGG 1140 CGCATCACAC TGAGGGCGTC CAATGGCAAG TTTGTGACCT CCAAGAAGAA TGGGCAGCTG 1200 GCCGCCTCGG TGGAGACAGC AGGGGACTCA GAGCTCTTCC TCATGAAGCT CATCAACCGC 1260 CCCATCATCG TGTTCCGCGG GGAGCATGGC TTCATCGGCT GCCGCAAGGT CACGGGCACC 1320 CTGGACGCCA ACCGCTCCAG CTATGACGTC TTCCAGCTGG AGTTCAACGA TGGCGCCTAC 1380 AACATCAAAG ACTCCACAGG CAAATACTGG ACGGTGGGCA GTGACTCCGC GGTCACCAGC 1440 AGCGGCGACA CTCCTGTGGA CTTCTTCTTC GAGTTCTGCG ACTATAACAA GGTGGCCATC 1500 AAGGTGGGCG GGCGCTACCT GAAGGGCGAC CACGCAGGCG TCCTGAAGGC CTCGGCGGAA 1560 ACCGTGGACC CCGCCTCGCT CTGGGAGTAC TAGGGCCGGC CCGTCCTTCC CCGCCCCTGC 1620 CCACATGGCG GCTCCTGCCA ACCCTCCCTG CTAACCCCTT CTCCGCCAGG TGGGCTCCAG 1680 GGCGGGAGGC AAGCCCCCTT GCCTTTCAAA CTGGAAACCC CAGAGAAAAC GGTGCCCCCA 1740 CCTGTCGCCC CTATGGACTC CCCACTCTCC CCTCCGCCCG GGTTCCCTAC TCCCCTCGGG 1800 TCAGCGGCTG CGGCCTGGCC CTGGGAGGGA TTTCAGATGC CCCTGCCCTC TTGTCTGCCA 1860

CGGGGCGAGT CTGGCACCTC TTTCTTCTGA CCTCAGACGG CTCTGAGCCT TATTTCTCTG 1920

GAAGCGGCTA AGGGACGGTT GGGGGCTGGG AGCCCTGGGC GTGTAGTGTA ACTGGAATCT 1980

TTTGCCTCTC CCAGCCACCT CCTCCCAGCC CCCCAGGAGA GCTGGGCACA TGTCCCAAGC 2040

CTGTCAGTGG CCCTCCCTGG TGCACTGTCC CCGAAACCCC TGCTTGGGAA GGGAAGCTGT 2100

CGGGAGGGCT AGGACTGACC CTTGTGGTGT TTTTTTGGGT GGTGGCTGGA AACAGCCCCT 2160

CTCCCACGTG GGAGAGGCTC AGCCTGGCTC CCTTCCCTGG AGCGGCAGGG CGTGACGGCC 2220

ACAGGGTCTG CCCGCTGCAC GTTCTGCCAA GGTGGTGGTG GCGGGCGGGT AGGGGTGTGG 2280

GGGCCGTCTT CCTCCTGTCT CTTTCCTTTC ACCCTAGCCT GACTGGAAGC AGAAAATGAC 2340

CAAATCAGTA TTTTTTTTAA TGAAATATTA TTGCTGGAGG CGTCCCAGGC AAGCCTGGCT 2400

GTAGTAGCGA GTGATCTGGC GGGGGGCGTC TCAGCACCCT CCCCAGGGGG TGCATCTCAG 2460

CCCCCTCTTT CCGTCCTTCC CGTCCAGCCC CAGCCCTGGG CCTGGGCTGC CGACACCTGG 2520

GCCAGAGCCC CTGCTGTGAT TGGTGCTCCC TGGGCCTCCC GGGTGGATGA AGCCAGGCGT 2580

CGCCCCCTCC GGGAGCCCTG GGGTGAGCCG CCGGGGCCCC CCTGCTGCCA GCCTCCCCCG 2640

TCCCCAACAT GCATCTCACT CTGGGTGTCT TGGTCTTTTA TTTTTTGTAA GTGTCATTTG 2700

TATAACTCTA AACGCCCATG ATAGTAGCTT CAAACTGGAA ATAGCGAAAT AAAATAACTC 2760 AGTCTGC

Seq ID NO: 341 Protein sequence Protein Accession ft: NP 003079

11 21 31 41 51

I

MTANGTAEAV Q IIQFGLINCG NKYLTAEAFG FKVNASASSL K IKKQIWTLEQ PPDEAGSAAV 60 CLRSHLGRYL AADKDGNVTC EREVPGPDCR F IVAHDDGR WSLQSEAHRR YFGGTEDRLS 120 CFAQTVSPAE KWSVHIAMHP QVNIYSVTRK RYAHLSARPA DEIAVDRDVP WGVDSLITLA 180 FQDQRYSVQT ADHRFLRHDG RLVARPEPAT GYTLEFRSGK VAFRDCEGRY LAPSGPSGTL 240 KAGKATKVGK DELFALEQSC AQWLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDR 300 DTKKCAFRTH TGKYWTLTAT GGVQSTASSK NASCYFDIEW RDRRITLRAS NGKFVTSKKN 360 GQLAASVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV TGTLDANRSS YDVFQLEFND 420 GAYNIKDSTG KYWTVGSDSA VTSSGDTPVD FFFEFCDYNK VAIKVGGRYL KGDHAGVLKA 480 SAETVDPASL WEY Seq ID NO: 342 DNA sequence

Nucleic Acid Accession ft: FGENESH predicted Coding sequence: 660..1705

60

120

180

CTCGAGCGGG ACAGATCCAA GTTGGGAGCA GCTCTGCGTG CGGGGCCTCA GAGAATGAGG 240

CCGGCGTTCG CCCTGTGCCT CCTCTGGCAG GCGCTCTGGC CCGGGCCGGG CGGCGGCGAA 300

CACCCCACTG CCGACCGTGC TGGCTGCTCG GCCTCGGGGG CCTGCTACAG CCTGCACCAC 360

GCTACCATGA AGCGGCAGGC GGCCGAGGAG GCCTGCATCC TGCGAGGTGG GGCGCTCAGC 420

ACCGTGCGTG CGGGCGCCGA GCTGCGCGCT GTGCTCGCGC TCCTGCGGGC AGGCCCAGGG 480

CCCGGAGGGG GCTCCAAAGA CCTGCTGTTC TGGGTCGCAC TGGAGCGCAG GCGTTCCCAC 540

TGCACCCTGG AGAACGAGCC TTTGCGGGGT TTCTCCTGGC TGTCCTCCGA CCCCGGCGGT 600

CTCGAAAGCG ACACGCTGCA GTGGGTGGAG GAGCCCCAAC GCTCCTGCAC CGCGCGGAGA 660

TGCGCGGTAC TCCAGGCCAC CGGTGGGGTC GAGCCCGCAG CTGGAAGGAG ATGCGATGCC 720

ACCTGCGCGC CAACGGCTAC CTGTGCAAGT ACCAGTTTGA GGTCTTGTGT CCTGCGCCGC 780

GCCCCGGGGC CGCCTCTAAC TTGAGCTATC GCGCGCCCTT CCAGCTGCAC AGCGCCGCTC 840

TGGACTTCAG TCCACCTGGG ACCGAGGTGA GTGCGCTCTG CCGGGGACAG CTCCCGATCT 900

CAGTTACTTG CATCGCGGAC GAAATCGGCG CTCGCTGGGA CAAACTCTCG GGCGATGTGT 960

TGTGTCCCTG CCCCGGGAGG TACCTCCGTG CTGGCAAATG CGCAGAGCTC CCTAACTGCC 1020

TAGACGACTT GGGAGGCTTT GCCTGCGAAT GTGCTACGGG CTTCGAGCTG GGGAAGGACG 1080

GCCGCTCTTG TGTGACCAGT GGGGAAGGAC AGCCGACCCT TGGGGGGACC GGGGTGCCCA 1140

CCAGGCGCCC GCCGGCCACT GCAACCAGCC CCGTGCCGCA GAGAACATGG CCAATCAGGG 1200

TCGACGAGAA GCTGGGAGAG ACACCACTTG TCCCTGAACA AGACAATTCA GTAACATCTA 1260

TTCCTGAGAT TCCTCGATGG GGATCACAGA GCACGATGTC TACCCTTCAA ATGTCCCTTC 1320

AAGCCGAGTC AAAGGCCACT ATCACCCCAT CAGGGAGCGT GATTTCCAAG TTTAATTCTA 1380

CGACTTCCTC TGCCACTCCT CAGGCTTTCG ACTCCTCCTC TGCCGTGGTC TTCATATTTG 1440

TGAGCACAGC AGTAGTAGTG TTGGTGATCT TGACCATGAC AGTACTGGGG CTTGTCAAGC 1500

TCTGCTTTCA CGAAAGCCCC TCTTCCCAGC CAAGGAAGGA GTCTATGGGC CCGCCGGGCC 1560

TGGAGAGTGA TCCTGAGCCC GCTGCTTTGG GCTCCAGTTC TGCACATTGC ACAAACAATG 1620

GGGTGAAAGT CGGGGACTGT GATCTGCGGG ACAGAGCAGA GGGTGCCTTG CTGGCGGAGT 1680

CCCCTCTTGG CTCTAGTGAT GCATAG

Seq ID NO: 343 Protein sequence Protein Accession ft: FGENESH predicted

11 21 31 41 51

MGKDFMTKTP K IAFATKAKID I

K IWDLIKLKSF CTAKETIIRV N ISQPTDWQKT FAIYPSDKGV 60 IARIYKELEQ IYKKKKPTKT LRTHFLSRPK GNCWPLGPRG DSWQLGGPSG ARAEGKGGGT 120 GLGKPAVEGG DRAPDTALRP RAGQIQVGSS SACGASENEA GVRPVPPLAG ALARAGRRRT 180 PHCRPCWLLG LGGLLQPAPR YHEAAGGRGG LHPARWGAQH RACGRRAARC ARAPAGRPRA 240 RRGLQRPAVL GRTGAQAFPL HPGERAFAGF LLAVLRPRRS RKRHAAVGGG APTLLHRAEM 300 RGTPGHRWGR ARSWKEMRCH LRANGYLCKY QFEVLCPAPR PGAASNLSYR APFQLHSAAL 360 DPSPPGTEVS ALCRGQLPIS VTCIADEIGA RWDKLSGDVL CPCPGRYLRA GKCAELPNCL 420 DDLGGFACEC ATGFELGKDG RSCVTSGEGQ PTLGGTGVPT RRPPATATSP VPQRTWPIRV 480 DEKLGETPLV PEQDNSVTSI PEIPRWGSQS TMSTLQMSLQ AESKATITPS GSVISKFNST 540 TSSATPQAFD SSSAWFIFV STAVWLVIL TMTVLGLVKL CFHESPSSQP RKESMGPPGL 600 ESDPEPAALG SSSAHCTNNG VKVGDCDLRD RAEGALLAES PLGSSDA Seq ID NO: 344 DNA sequence Nucleic Acid Accession ft: NM_012072 Coding sequence: 149-2107

11 21 31 41 51

I I I I I

AAAGCCCTCA GCCTTTGTGT CCTTCTCTGC GCCGGAGTGG CTGCAGCTCA CCCCTCAGCT 60 CCCCTTGGGG CCCAGCTGGG AGCCGAGATA GAAGCTCCTG TCGCCGCTGG GCTTCTCGCC 120 TCCCGCAGAG GGCCACACAG AGACCGGGAT GGCCACCTCC ATGGGCCTGC TGCTGCTGCT 180 GCTGCTGCTC CTGACCCAGC CCGGGGCGGG GACGGGAGCT GACACGGAGG CGGTGGTCTG 240 CGTGGGGACC GCCTGCTACA CGGCCCACTC GGGCAAGCTG AGCGCTGCCG AGGCCCAGAA 300 CCACTGCAAC CAGAACGGGG GCAACCTGGC CACTGTGAAG AGCAAGGAGG AGGCCCAGCA 360 CGTCCAGCGA GTACTGGCCC AGCTCCTGAG GCGGGAGGCA GCCCTGACGG CGAGGATGAG 420 CAAGTTCTGG ATTGGGCTCC AGCGAGAGAA GGGCAAGTGC CTGGACCCTA GTCTGCCGCT 480 GAAGGGCTTC AGCTGGGTGG GCGGGGGGGA GGACACGCCT TACTCTAACT GGCACAAGGA 540 GCTCCGGAAC TCGTGCATCT CCAAGCGCTG TGTGTCTCTG CTGCTGGACC TGTCCCAGCC 600 GCTCCTTCCC AACCGCCTGC CCAAGTGGTC TGAGGGCCCC TGTGGGAGCC CAGGCTCCCC 660 CGGAAGTAAC ATTGAGGGCT TCGTGTGCAA GTTCAGCTTC AAAGGCATGT GCCGGCCTCT 720 GGCCCTGGGG GGCCCAGGTC AGGTGACCTA CACCACCCCC TTCCAGACCA CCAGTTCCTC 780 CTTGGAGGCT GTGCCCTTTG CCTCTGCGGC CAATGTAGCC TGTGGGGAAG GTGACAAGGA 840 CGAGACTCAG AGTCATTATT TCCTGTGCAA GGAGAAGGCC CCCGATGTGT TCGACTGGGG 900 CAGCTCGGGC CCCCTCTGTG TCAGCCCCAA GTATGGCTGC AACTTCAACA ATGGGGGCTG 960 CCACCAGGAC TGCTTTGAAG GGGGGGATGG CTCCTTCCTC TGCGGCTGCC GACCAGGATT 1020 CCGGCTGCTG GATGACCTGG TGACCTGTGC CTCTCGAAAC CCTTGCAGCT CCAGCCCATG 1080 TCGTGGGGGG GCCACGTGCG TCCTGGGACC CCATGGGAAA AACTACACGT GCCGCTGCCC 1140 CCAAGGGTAC CAGCTGGACT CGAGTCAGCT GGACTGTGTG GACGTGGATG AATGCCAGGA 1200 CTCCCCCTGT GCCCAGGAGT GTGTCAACAC CCCTGGGGGC TTCCGCTGCG AATGCTGGGT 1260 TGGCTATGAG CCGGGCGGTC CTGGAGAGGG GGCCTGTCAG GATGTGGATG AGTGTGCTCT 1320 GGGTCGCTCG CCTTGCGCCC AGGGCTGCAC CAACACAGAT GGCTCATTTC ACTGCTCCTG 1380 TGAGGAGGGC TACGTCCTGG CCGGGGAGGA CGGGACTCAG TGCCAGGACG TGGATGAGTG 1440 TGTGGGCCCG GGGGGCCCCC TCTGCGACAG CTTGTGCTTC AACACACAAG GGTCCTTCCA 1500 CTGTGGCTGC CTGCCAGGCT GGGTGCTGGC CCCAAATGGG GTCTCTTGCA CCATGGGGCC 1560 TGTGTCTCTG GGACCACCAT CTGGGCCCCC CGATGAGGAG GACAAAGGAG AGAAAGAAGG 1620 GAGCACCGTG CCCCGCGCTG CAACAGCCAG TCCCACAAGG GGCCCCGAGG GCACCCCCAA 1680 GGCTACACCC ACCACAAGTA GACCTTCGCT GTCATCTGAC GCCCCCATCA CATCTGCCCC 1740 ACTCAAGATG CTGGCCCCCA GTGGGTCCTC AGGCGTCTGG AGGGAGCCCA GCATCCATCA 1800 CGCCACAGCT GCCTCTGGCC CCCAGGAGCC TGCAGGTGGG GACTCCTCCG TGGCCACACA 1860 AAACAACGAT GGCACTGACG GGCAAAAGCT GCTTTTATTC TACATCCTAG GCACCGTGGT 1920 GGCCATCCTA CTCCTGCTGG CCCTGGCTCT GGGGCTACTG GTCTATCGCA AGCGGAGAGC 1980 GAAGAGGGAG GAGAAGAAGG AGAAGAAGCC CCAGAATGCG GCAGACAGTT ACTCCTGGGT 2040 TCCAGAGCGA GCTGAGAGCA GGGCCATGGA GAACCAGTAC AGTCCGACAC CTGGGACAGA 2100 CTGCTGAAAG TGAGGTGGCC CTAGAGACAC TAGAGTCACC AGCCACCATC CTCAGAGCTT 2160 TGAACTCCCC ATTCCAAAGG GGCACCCACA TTTTTTTGAA AGACTGGACT GGAATCTTAG 2220 CAAACAATTG TAAGTCTCCT CCTTAAAGGC CCCTTGGAAC ATGCAGGTAT TTTCTACGGG 2280 TGTTTGATGT TCCTGAAGTG GAAGCTGTGT GTTGGCGTGC CACGGTGGGG ATTTCGTGAC 2340 TCTATAATGA TTGTTACTCC CCCTCCCTTT TCAAATTCCA ATGTGACCAA TTCCGGATCA 2400 GGGTGTGAGG AGGCTGGGGC TAAGGGGCTC CCCTGAATAT CTTCTCTGCT CACTTCCACC 2460 ATCTAAGAGG AAAAGGTGAG TTGCTCATGC TGATTAGGAT TGAAATGATT TGTTTCTCTT 2520 CCTAGGATGA AAACTAAATC AATTAATTAT TCAATTAGGT AAGAAGATCT GGTTTTTTGG 2580 TCAAAGGGAA CATGTTCGGA CTGGAAACAT TTCTTTACAT TTGCATTCCT CCATTTCGCC 2640 AGCACAAGTC TTGCTAAATG TGATACTGTT GACATCCTCC AGAATGGCCA GAAGTGCAAT 2700 TAACCTCTTA GGTGGCAAGG AGGCAGGAAG TGCCTCTTTA GTTCTTACAT TTCTAATAGC 2760 CTTGGGTTTA TTTGCAAAGG AAGCTTGAAA AATATGAGAA AAGTTGCTTG AAGTGCATTA 2820 CAGGTGTTTG TGAAGTCACA TAATCTACGG GGCTAGGGCG AGAGAGGCCA GGGATTTGTT 2880 CACAGATACT TGAATTAATT CATCCAAATG TACTGAGGTT ACCACACACT TGACTACGGA 2940 TGTGATCAAC ACTAACAAGG AAACAAATTC AAGGACAACC TGTCTTTGAG CCAGGGCAGG 3000 CCTCAGACAC CCTGCCTGTG GCCCCGCCTC CACTTCATCC TGCCCGGAAT GCCAGTGCTC 3060 CGAGCTCAGA CAGAGGAAGC CCTGCAGAAA GTTCCATCAG GCTGTTTCCT AAAGGATGTG 3120 TGAACGGGAG ATGATGCACT GTGTTTTGAA AGTTGTCATT TTAAAGCATT TTAGCACAGT 3180 TCATAGTCCA CAGTTGATGC AGCATCCTGA GATTTTAAAT CCTGAAGTGT GGGTGGCGCA 3240 CACACCAAGT AGGGAGCTAG TCAGGCAGTT TGCTTAAGGA ACTTTTGTTC TCTGTCTCTT 3300 TTCCTTAAAA TTGGGGGTAA GGAGGGAAGG AAGAGGGAAA GAGATGACTA ACTAAAATCA 3360 TTTTTACAGC AAAAACTGCT CAAAGCCATT TAAATTATAT CCTCATTTTA AAAGTTACAT 3420 TTGCAAATAT TTCTCCCTAT GATAATGCAG TCGATAGTGT GCACTCTTTC TCTCTCTCTC 3480 TCTCTCTCAC ACACACACAC ACACACACAC ACACACACAC AGAGACACGG CACCATTCTG 3540 CCTGGGGCAC TGGAACACAT TCCTGGGGGT CACCGATGGT CAGAGTCACT AGAAGTTACC 3600 TGAGTATCTC TGGGAGGCCT CATGTCTCCT GTGGGCTTTT TACCACCACT GTGCAGGAGA 3660 ACAGACAGAG GAAATGTGTC TCCCTCCAAG GCCCCAAAGC CTCAGAGAAA GGGTGTTTCT 3720 GGTTTTGCCT TAGCAATGCA TCGGTCTCTG AGGTGACACT CTGGAGTGGT TGAAGGGCCA 3780 CAAGGTGCAG GGTTAATACT CTTGCCAGTT TTGAAATATA GATGCTATGG TTCAGATTGT 3840 TTTTAATAGA AAACTAAAGG GGCAGGGGAA GTGAAAGGAA AGATGGAGGT TTTGTGCGGC 3900 TCGATGGGGC ATTTGGAACT TCTTTTTAAA GTCATCTCAT GGTCTCCAGT TTTCAGTTGG 3960 AACTCTGGTG TTTAACACTT AAGGGAGACA AAGGCTGTGT CCATTTGGCA AAACTTCCTT 4020 GGCCACGAGA CTCTAGGTGA TGTGTGAAGC TGGGCAGTCT GTGGTGTGGA GAGCAGCCAT 4080 CTGTCTGGCC ATTCAGAGGA TTCTAAAGAC ATGGCTGGAT GCGCTGCTGA CCAACATCAG 4140 CACTTAAATA AATGCAAATG CAACATTTCT CCCTCTGGGC CTTGAAAATC CTTGCCCTTA 4200 TCATTTGGGG TGAAGGAGAC ATTTCTGTCC TTGGCTTCCC ACAGCCCCAA CGCAGTCTGT 4260 GTATGATTCC TGGGATCCAA CGAGCCCTCC TATTTTCACA GTGTTCTGAT TGCTCTCACA 4320 GCCCAGGCCC ATCGTCTGTT CTCTGAATGC AGCCCTGTTC TCAACAACAG GGAGGTCATG 4380 GAACCCCTCT GTGGAACCCA CAAGGGGAGA AATGGGTGAT AAAGAATCCA GTTCCTCAAA 4440 ACCTTCCCTG GCAGGCTGGG TCCCTCTCCT GCTGGGTGGT GCTTTCTCTT GCACACCACT 4500 CCCACCACGG GGGGAGAGCC AGCAACCCAA CCAGACAGCT CAGGTTGTGC ATCTGATGGA 4560 AACCACTGGG CTCAAACACG TGCTTTATTC TCCTGTTTAT TTTTGCTGTT ACTTTGAAGC 4620 ATGGAAATTC TTGTTTGGGG GATCTTGGGG CTACAGTAGT GGGTAAACAA ATGCCCACCG 4680 GCCAAGAGGC CATTAACAAA TCGTCCTTGT CCTGAGGGGC CCCAGCTTGC TCGGGCGTGG 4740 CACAGTGGGG AATCCAAGGG TCACAGTATG GGGAGAGGTG CACCCTGCCA CCTGCTAACT 4800 ^■ TCTCGCTAGA CACAGTGTTT CTGCCCAGGT GACCTGTTCA GCAGCAGAAC AAGCCAGGGC 4860

CATGGGGACG GGGGAAGTTT TCACTTGGAG ATGGACACCA AGACAATGAA GATTTGTTGT 4920

CCAAATAGGT CAATAATTCT GGGAGACTCT TGGAAAAAAC TGAATATATT CAGGACCAAC 4980

TCTCTCCCTC CCCTCATCCC ACATCTCAAA GCAGACAATG TAAAGAGAGA ACATCTCACA 5040

CACCCAGCTC GCCATGCCTA CTCATTCCTG AATTTCAGGT GCCATCACTG CTCTTTCTTT 5100

CTTCTTTGTC ATTTGAGAAA GGATGCAGGA GGACAATTCC CACAGATAAT CTGAGGAATG 5160

CAGAAAAACC AGGGCAGGAC AGTTATCGAC AATGCATTAG AACTTGGTGA GCATCCTCTG 5220

TAGAGGGACT CCACCCCTGC TCAACAGCTT GGCTTCCAGG CAAGACCAAC CACATCTGGT 5280

CTCTGCCTTC GGTGGCCCAC ACACCTAAGC GTCATCGTCA TTGCCATAGC ATCATGATGC 5340

AACACATCTA CGTGTAGCAC TACGACGTTA TGTTTGGGTA ATGTGGGGAT GAACTGCATG 5400

AGGCTCTGAT TAAGGATGTG GGGAAGTGGG CTGCGGTCAC TGTCGGCCTT GCAAGGCCAC 5460

CTGGAGGCCT GTCTGTTAGC CAGTGGTGGA GGAGCAAGGC TTCAGGAAGG GCCAGCCACA 5520

TGCCATCTTC CCTGCGATCA GGCAAAAAAG TGGAATTAAA AAGTCAAACC TTTATATGCA 5580

TGTGTTATGT CCATTTTGCA GGATGAACTG AGTTTAAAAG AATTTTTTTT TCTCTTCAAG 5640

TTGCTTTGTC TTTTCCATCC TCATCACAAG CCCTTGTTTG AGTGTCTTAT CCCTGAGCAA 5700

TCTTTCGATG GATGGAGATG ATCATTAGGT ACTTTTGTTT CAACCTTTAT TCCTGTAAAT 5760

ATTTCTGTGA AAACTAGGAG AACAGAGATG AGATTTGACA AAAAAAAATT GAATTAAAAA 5820

TAACACAGTC TTTTTAAAAC TAACATAGGA AAGCCTTTCC TATTATTTCT CTTCTTAGCT 5880

TCTCCATTGT CTAAATCAGG AAAACAGGAA AACACAGCTT TCTAGCAGCT GCAAAATGGT 5940

TTAATGCCCC CTACATATTT CCATCACCTT GAACAATAGC TTTAGCTTGG GAATCTGAGA 6000

TATGATCCCA GAAAACATCT GTCTCTACTT CGGCTGCAAA ACCCATGGTT TAAATCTATA 6060

TGGTTTGTGC ATTTTCTCAA CTAAAAATAG AGATGATAAT CCGAATTCTC CATATATTCA 6120

CTAATCAAAG ACACTATTTT CATACTAGAT TCCTGAGACA AATACTCACT GAAGGGCTTG 6180

TTTAAAAATA AATTGTGTTT TGGTCTGTTC TTGTAGATAA TGCCCTTCTA TTTTAGGTAG 6240

AAGCTCTGGA ATCCCTTTAT TGTGCTGTTG CTCTTATCTG CAAGGTGGCA AGCAGTTCTT 6300

TTCAGCAGAT TTTGCCCACT ATTCCTCTGA GCTGAAGTTC TTTGCATAGA TTTGGCTTAA 6360

GCTTGAATTA GATCCCTGCA AAGGCTTGCT CTGTGATGTC AGATGTAATT GTAAATGTCA 6420

GTAATCACTT CATGAATGCT AAATGAGAAT GTAAGTATTT TTAAATGTGT GTATTTCAAA 6480

TTTGTTTGAC TAATTCTGGA ATTACAAGAT TTCTATGCAG GATTTACCTT CATCCTGTGC 6540

ATGTTTCCCA AACTGTGAGG AGGGAAGGCT CAGAGATCGA GCTTCTCCTC TGAGTTCTAA 6600

CAAAATGGTG CTTTGAGGGT CAGCCTTTAG GAAGGTGCAG CTTTGTTGTC CTTTGAGCTT 6660 TGTGTTATGT GCCTATCCTA ATAAACTCTT AAACACATT

Seq ID NO: 345 Protein sequence Protein Accession ft: NP_036204

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MATSMGLLLL LLLLLTQPGA GTGADTEAW CVGTACYTAH SGKLSAAEAQ NHCNQNGGNL 60

ATVKSKEEAQ HVQRVLAQLL RREAALTARM SKFWIGLQRE KGKCLDPSLP LKGFSWVGGG 120

EDTPYSNWHK ELRNSCISKR CVSLLLDLSQ PLLPNRLPKW SEGPCGSPGS PGSNIEGFVC 180

KFSFKGMCRP LALGGPGQVT YTTPFQTTSS SLEAVPFASA ANVACGEGDK DETQSHYFLC 240

KEKAPDVFDW GSSGPLCVSP KYGCNFNNGG CHQDCFEGGD GSFLCGCRPG FRLLDDLVTC 300

ASRNPCSSSP CRGGATCVLG PHGKNYTCRC PQGYQLDSSQ LDCVDVDECQ DSPCAQECVN 360

TPGGFRCECW VGYEPGGPGE GACQDVDECA LGRSPCAQGC TNTDGSFHCS CEEGYVLAGE 420

DGTQCQDVDE CVGPGGPLCD SLCFNTQGSF HCGCLPGWVL APNGVSCTMG PVSLGPPSGP 480

PDEEDKGEKE GSTVPRAATA SPTRGPEGTP KATPTTSRPS LSSDAPITSA PLKMLAPSGS 540

SGVWREPSIH HATAASGPQE PAGGDSSVAT QNNDGTDGQK LLLFYILGTV VAILLLLALA 600 LGLLVYRKRR AKREEKKEKK PQNAADSYSW VPERAESRAM ENQYSPTPGT DC

Seq ID NO: 346 DNA sequence Nucleic Acid Accession ft: Z31560 Coding sequence: <l-966

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CACAGCGCCC GCATGTACAA CATGATGGAG ACGGAGCTGA AGCCGCCGGG CCCGCAGCAA 60

ACTTCGGGGG GCGGCGGCGG CAACTCCACC GCGGCGGCGG CCGGCGGCAA CCAGAAAAAC 120

AGCCCGGACC GCGTCAAGCG GCCCATGAAT GCCTTCATGG TGTGGTCCCG CGGGCAGCGG 180

CGCAAGATGG CCCAGGAGAA CCCCAAGATG CACAACTCGG AGATCAGCAA GCGCCTGGGC 240

GCCGAGTGGA AACTTTTGTC GGAGACGGAG AAGCGGCCGT TCATCGACGA GGCTAAGCGG 300

CTGCGAGCGC TGCACATGAA GGAGCACCCG GATTATAAAT ACCGGCCCCG GCGGAAAACC 360

AAGACGCTCA TGAAGAAGGA TAAGTACACG CTGCCCGGCG GGCTGCTGGC CCCCGGCGGC 420

AATAGCATGG CGAGCGGGGT CGGGGTGGGC GCCGGCCTGG GCGCGGGCGT GAACCAGCGC 480

ATGGACAGTT ACGCGCACAT GAACGGCTGG AGCAACGGCA GCTACAGCAT GATGCAGGAC 540

CAGCTGGGCT ACCCGCAGCA CCCGGGCCTC AATGCGCACG GCGCAGCGCA GATGCAGCCC 600

ATGCACCGCT ACGACGTGAG CGCCCTGCAG TACAACTCCA TGACCAGCTC GCAGACCTAC 660

ATGAACGGCT CGCCCACCTA CAGCATGTCC TACTCGCAGC AGGGCACCCC TGGCATGGCT 720

CTTGGCTCCA TGGGTTCGGT GGTCAAGTCC GAGGCCAGCT CCAGCCCCCC TGTGGTTACC 780

TCTTCCTCCC ACTCCAGGGC GCCCTGCCAG GCCGGGGACC TCCGGGACAT GATCAGCATG 840

TATCTCCCCG GCGCCGAGGT GCCGGAACCC GCCGCCCCCA GCAGACTTCA CATGTCCCAG 900

CACTACCAGA GCGGCCCGGT GCCCGGCACG GCCATTAACG GCACACTGCC CCTCTCACAC 960

ATGTGAGGGC CGGACAGCGA ACTGGAGGGG GGAGAAATTT TCAAAGAAAA ACGAGGGAAA 1020

TGGGAGGGGT GCAAAAGAGG AGAGTAAGAA ACAGCATGGA GAAAACCCGG TACGCTCAAA 1080 AAAAA

Seq ID NO: 347 Protein sequence Protein Accession ft: CAA83435

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HSARMYNMME TELKPPGPQQ TSGGGGGNST AAAAGGNQKN SPDRVKRPMN AFMVWSRGQR 60

RKMAQENPKM HNSEISKRLG AEWKLLSETE KRPFIDEAKR LRALHMKEHP DYKYRPRRKT 120

KTLMKKDKYT LPGGLLAPGG NSMASGVGVG AGLGAGVNQR MDSYAHMNGW SNGSYSMMQD 180

QLGYPQHPGL NAHGAAQMQP MHRYDVSALQ YNSMTSSQTY MNGSPTYSMS YSQQGTPGMA 240

LGSMGSWKS EASSSPPWT SSSHSRAPCQ AGDLRDMISM YLPGAEVPEP AAPSRLHMSQ 300 HYQSGPVPGT AINGTLPLSH M Seq ID NO: 348 DNA sequence Nucleotide Accession ft: NM_002638 Coding sequence: 120-473

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CAATACAGCT AAGGAATTAT CCCTTGTAAA TACCACAGAC CCGCCCTGGA GCCAGGCCAA 60

GCTGGACTGC ATAAAGATTG GTATGGCCTT AGCTCTTAGC CAAACACCTT CCTGACACCA 120

TGAGGGCCAG CAGCTTCTTG ATCGTGGTGG TGTTCCTCAT CGCTGGGACG CTGGTTCTAG 180

AGGCAGCTGT CACGGGAGTT CCTGTTAAAG GTCAAGACAC TGTCAAAGGC CGTGTTCCAT 240

TCAATGGACA AGATCCCGTT AAAGGACAAG TTTCAGTTAA AGGTCAAGAT AAAGTCAAAG 300

CGCAAGAGCC AGTCAAAGGT CCAGTCTCCA CTAAGCCTGG CTCCTGCCCC ATTATCTTGA 360

TCCGGTGCGC CATGTTGAAT CCCCCTAACC GCTGCTTGAA AGATACTGAC TGCCCAGGAA 420

TCAAGAAGTG CTGTGAAGGC TCTTGCGGGA TGGCCTGTTT CGTTCCCCAG TGAAGGGAGC 480

CGGTCCTTGC TGCACCTGTG CCGTCCCCAG AGCTACAGGC CCCATCTGGT CCTAAGTCCC 540

TGCTGCCCTT CCCCTTCCCA CACTGTCCAT TCTTCCTCCC ATTCAGGATG CCCACGGCTG 600 GAGCTGCCTC TCTCATCCAC TTTCCAATAA A

Seq ID NO: 349 Protein sequence: Protein Accession ft: NP_002629

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MRASSFLIW VFLIAGTLVL EAAVTGVPVK GQDTVKGRVP FNGQDPVKGQ VSVKGQDKVK 60 AQEPVKGPVS TKPGSCPIIL IRCAMLNPPN RCLKDTDCPG IKKCCEGSCG MACFVPQ

Seq ID NO: 350 DNA sequence Nucleic Acid Accession ft: NM 007183

Coding sequence: 75-2468

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GAATTCCGGA CAGGACGTGA AGATAGTTGG GTTTGGAGGC GGCCGCCAGG CCCAGGCCCG 60

GTGGACCTGC CGCCATGCAG GACGGTAACT TCCTGCTGTC GGCCCTGCAG CCTGAGGCCG 120

GCGTGTGCTC CCTGGCGCTG CCCTCTGACC TGCAGCTGGA GCGCCGGGGC GCCGAGGGGC 180

CGGAGGCCGA GCGGCTGCGG GCAGCCCGCG TCCAGGAGCA GGTCCGCGCC CGCCTCTTGC 240

AGCTGGGACA GCAGCCGCGG CACAACGGGG CCGCTGAGCC CGAGCCTGAG GCCGAGACTG 300

CCAGAGGCAC ATCCAGGGGG CAGTACCACA CCCTGCAGGC TGGCTTCAGC TCTCGCTCTC 360

AGGGCCTGAG TGGGGACAAG ACCTCGGGCT TCCGGCCCAT CGCCAAGCCG GCCTACAGCC 420

CAGCCTCCTG GTCCTCCCGC TCCGCCGTGG ATCTGAGCTG CAGTCGGAGG CTGAGTTCAG 480

CCCACAATGG GGGCAGCGCC TTTGGGGCCG CTGGGTACGG GGGTGCCCAG CCCACCCCTC 540

CCATGCCCAC CAGGCCCGTG TCCTTCCATG AGCGCGGTGG GGTTGGGAGC CGGGCCGACT 600

ATGACACACT CTCCCTGCGC TCGCTGCGGC TGGGGCCCGG GGGCCTGGAC GACCGCTACA 660

GCCTGGTGTC TGAGCAGCTG GAGCCCGCGG CCACCTCCAC CTACAGGGCC TTTGCGTACG 720

AGCGCCAGGC CAGCTCCAGC TCCAGCCGGG CAGGGGGGCT GGACTGGCCC GAGGCCACTG 780

AGGTTTCCCC GAGCCGGACC ATCCGTGCCC CTGCCGTGCG GACCCTGCAG CGATTCCAGA 840

GCAGCCACCG GAGCCGCGGG GTAGGCGGGG CAGTGCCGGG GGCCGTCCTG GAGCCAGTGG 900

CTCGAGCGCC ATCTGTGCGC AGCCTCAGCC TCAGCCTGGC TGACTCGGGC CACCTGCCGG 960

ACGTGCATGG GTTCAACAGC TACGGTAGCC ACCGAACCCT βCAGAGACTC AGCAGCGGTT 1020

TTGATGACAT TGACCTGCCC TCAGCAGTCA AGTACCTCAT GGCTTCAGAC CCCAACCTGC 1080

AGGTGCTGGG AGCGGCCTAC ATCCAGCACA AGTGCTACAG CGATGCAGCC GCCAAGAAGC 1140

AGGCCCGCAG CCTTCAGGCC GTGCCTAGGC TGGTGAAGCT CTTCAACCAC GCCAACCAGG 1200

AAGTGCAGCG CCATGCCACA GGTGCCATGC GCAACCTCAT CTACGACAAC GCTGACAACA 1260

AGCTGGCCCT GGTGGAGGAG AACGGGATCT TCGAGCTGCT GCGGACACTG CGGGAGCAGG 1320

ATGATGAGCT TCGCAAAAAT GTCACAGGGA TCCTGTGGAA CCTTTCATCC AGCGACCACC 1380

TGAAGGACCG CCTGGCCAGA GACACGCTGG AGCAGCTCAC GGACCTGGTG TTGAGCCCCC 1440

TGTCGGGGGC TGGGGGTCCC CCCCTCATCC AGCAGAACGC CTCGGAGGCG GAGATCTTCT 1500

ACAACGCCAC CGGCTTCCTC AGGAACCTCA GCTCAGCCTC TCAGGCCACT CGCCAGAAGA 1560

TGCGGGAGTG CCACGGGCTG GTGGACGCCC TGGTCACCTC TATCAACCAC GCCCTGGACG 1620

CGGGCAAATG CGAGGACAAG AGCGTGGAGA ACGCGGTGTG CGTCCTGCGG AACCTGTCCT 1680

ACCGCCTCTA CGACGAGATG CCGCCGTCCG CGCTGCAGCG GCTGGAGGGT CGCGGCCGCA 1740

GGGACCTGGC GGGGGCGCCG CCGGGAGAGG TCGTGGGCTG CTTCACGCCG CAGAGCCGGC 1800

GGCTGCGCGA GCTGCCCCTC GCCGCCGATG CGCTCACCTT CGCGGAGGTG TCCAAGGACC 1860

CCAAGGGCCT CGAGTGGCTG TGGAGCCCCC AGATCGTGGG GCTGTACAAC CGGCTGCTGC 1920

AGCGCTGCGA GCTCAACCGG CACACGACGG AGGCGGCCGC CGGGGCGCTG CAGAACATCA 1980

CGGCAGGCGA CCGCAGGTGG GCGGGGGTGC TGAGCCGCCT GGCCCTGGAG CAGGAGCGTA 2040

TTCTGAACCC CCTGCTAGAC CGTGTCAGGA CCGCCGACCA CCACCAGCTG CGCTCACTGA 2100

CTGGCCTCAT CCGAAACCTG TCTCGGAACG CTAGGAACAA GGACGAGATG TCCACGAAGG 2160

TGGTGAGCCA CCTGATCGAG AAGCTGCCAG GCAGCGTGGG TGAGAAGTCG CCCCCAGCCG 2220

AGGTGCTGGT CAACATCATA GCTGTGCTCA ACAACCTGGT GGTGGCCAGC CCCATCGCTG 2280

CCCGAGACCT GCTGTATTTT GACGGACTCC GAAAGCTCAT CTTCATCAAG AAGAAGCGGG 2340

ACAGCCCCGA CAGTGAGAAG TCCTCCCGGG CAGCATCCAG CCTCCTGGCC AACCTGTGGC 2400

AGTACAACAA GCTCCACCGT GACTTTCGGG CGAAGGGCTA TCGGAAGGAG GACTTCCTGG 2460

GCCCATAGGT GAAGCCTTCT GGAGGAGAAG GTGACGTGGC CCAGCGTCCA AGGGACAGAC 2520

TCAGCTCCAG GCTGCTTGGC AGCCCAGCCT GGAGGAGAAG GCTAATGACG GAGGGGCCCC 2580

TCGCTGGGGC CCCTGTGTGC ATCTTTGAGG GTCCTGGGCC ACCAGGAGGG GCAGGGTCTT 2640

ATAGCTGGGG ACTTGGCTTC CGCAGGGCAG GGGGTGGGGC AGGGCTCAAG GCTGCTCTGG 2700

TGTATGGGGT GGTGACCCAG TCACATTGGC AGAGGTGGGG GTTGGCTGTG GCCTGGCAGT 2760

ATCTTGGGAT AGCCAGCACT GGGAATAAAG ATGGCCATGA ACAGTCACAA AAAAAAAAAA 2820 AAAAGGAATT C

Seq ID NO: 351 Protein sequence Protein Accession ft: NP_009114.1

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MQDGNFLLSA LQPEAGVCSL ALPSDLQLDR RGAEGPEAER LRAARVQEQV RARLLQLGQQ 60

PRHNGAAEPE PEAETARGTS RGQYHTLQAG FSSRSQGLSG DKTSGFRPIA KPAYSPASWS 120

SRSAVDLSCS RRLSSAHNGG SAFGAAGYGG AQPTPPMPTR PVSFHERGGV GSRADYDTLS 180

LRSLRLGPGG LDDRYSLVSE QLEPAATSTY RAFAYERQAS SSSSRAGGLD WPEATEVSPS 240

RTIRAPAVRT LQRFQSSHRS RGVGGAVPGA VLEPVARAPS VRSLSLSLAD SGHLPDVHGF 300

NSYGSHRTLQ RLSSGFDDID LPSAVKYLMA SDPNLQVLGA AYIQHKCYSD AAAKKQARSL 360

QAVPRLVKLF NHANQEVQRH ATGAMRNLIY DNADNKLALV EENGIFELLR TLREQDDELR 420

KNVTGILWNL SSSDHLKDRL ARDTLEQLTD LVLSPLSGAG GPPLIQQNAS EAEIFYNATG 480

FLRNLSSASQ ATRQKMRECH GLVDALVTSI NHALDAGKCE DKSVENAVCV LRNLSYRLYD 540

EMPPSALQRL EGRGRRDLAG APPGEWGCF TPQSRRLREL PLAADALTFA EVSKDPKGLE 600

WLWSPQIVGL YNRLLQRCEL NRHTTEAAAG ALQNITAGDR RWAGVLSRLA LEQERILNPL 660

LDRVRTADHH QLRSLTGLIR NLSRNARNKD EMSTKWSHL IEKLPGSVGE KSPPAEVLVN 720

IIAVLNNLW ASPIAARDLL YFDGLRKLIF IKKKRDSPDS EKSSRAASSL LANLWQYNKL 780 HRDFRAKGYR KEDFLGP

Seq ID NO: 352 DNA sequence Nucleic Acid Accession ft: M31469 Coding sequence: 1-651

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ATGGCTGCGC AGGGAGAGCC CCAGGTCCAG TTCAAACTTG TATTGGTTGG TGATGGTGGT 60

ACTGGAAAAA CGACCTTCGT GAAACGTCAT TTGACTGGTG AATTTGAGAA GAAGTATGTA 120

GCCACCTTGG GTGTTGAGGT TCATCCCCTA GTGTTCCACA CCAACAGAGG ACCTATTAAG 180

TTCAATGTAT GGGACACAGC CGGCCAGGAG AAATTCGGTG GACTGAGAGA TGGCTATTAT 240

ATCCAAGCCC AGTGTGCCAT CATAATGTTT GATGTAACAT CGAGAGTTAC TTACAAGAAT 300

GTGCCTAACT GGCATAGAGA TCTGGTACGA GTGTGTGAAA ACATCCCCAT TGTGTTGTGT 360

GGCAACAAAG TGGATATTAA GGACAGGAAA GTGAAGGCGA AATCCATTGT CTTCCACCGA 420

AAGAAGAATC TTCAGTACTA CGACATTTCT GCCAAAAGTA ACTACAACTT TGAAAAGCCC 480

TTCCTCTGGC TTGCTAGGAA GCTCATTGGA GACCCTAACT TGGAATTTGT TGCCATGCCT 540

GCTCTCGCCC CACCAGAAGT TGTCATGGAC CCAGCTTTGG CAGCACAGTA TGAGCACGAC 600 TTAGAGGTTG CTCAGACAAC TGCTCTCCCG GATGAGGATG ATGACCTGTG A

Seq ID NO: 353 Protein sequence Protein Accession ft: AAA36546

1 11 21 31 41 51 i I I I I I

MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL VFHTNRGPIK 60

FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN VPNWHRDLVR VCENIPIVLC 120

GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS AKSNYNFEKP FLWLARKLIG DPNLEFVAMP 180 ALAPPEWMD PALAAQYEHD LEVAQTTALP DEDDDL

Seq ID NO: 354 DNA sequence Nucleic Acid Accession ft: NM_002820 Coding sequence: 304-831

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CCGGTTCGCA AAGAAGCTGA CTTCAGAGGG GGAAACTTTC TTCTTTTAGG AGGCGGTTAG 60

CCCTGTTCCA CGAACCCAGG AGAACTGCTG GCCAGATTAA TTAGACATTG CTATGGGAGA 120 CGTGTAAACA CACTACTTAT CATTGATGCA TATATAAAAC CATTTTATTT TCGCTATTAT 180

TTCAGAGGAA GCGCCTCTGA TTTGTTTCTT TTTTCCCTTT TTGCTCTTTC TGGCTGTGTG 240

GTTTGGAGAA AGCACAGTTG GAGTAGCCGG TTGCTAAATA AGTCCCGAGC GCGAGCGGAG 300

ACGATGCAGC GGAGACTGGT TCAGCAGTGG AGCGTCGCGG TGTTCCTGCT GAGCTACGCG 360

GTGCCCTCCT GCGGGCGCTC GGTGGAGGGT CTCAGCCGCC GCCTCAAAAG AGCTGTGTCT 420 GAACATCAGC TCCTCCATGA CAAGGGGAAG TCCATCCAAG ATTTACGGCG ACGATTCTTC 480

CTTCACCATC TGATCGCAGA AATCCACACA GCTGAAATCA GAGCTACCTC GGAGGTGTCC 540

CCTAACTCCA AGCCCTCTCC CAACACAAAG AACCACCCCG TCCGATTTGG GTCTGATGAT 600

GAGGGCAGAT ACCTAACTCA GGAAACTAAC AAGGTGGAGA CGTACAAAGA GCAGCCGCTC 660

AAGACACCTG GGAAGAAAAA GAAAGGCAAG CCCGGGAAAC GCAAGGAGCA GGAAAAGAAA 720 AAACGGCGAA CTCGCTCTGC CTGGTTAGAC TCTGGAGTGA CTGGGAGTGG GCTAGAAGGG 780

GACCACCTGT CTGACACCTC CACAACGTCG CTGGAGCTCG ATTCACGGTA ACAGGCTTCT 840

CTGGCCCGTA GCCTCAGCGG GGTGCTCTCA GCTGGGTTTT GGAGCCTCCC TTCTGCCTTG 900

GCTTGGACAA ACCTAGAATT TTCTCCCTTT ATGTATCTCT ATCGATTGTG TAGCAATTGA 960

CAGAGAATAA CTCAGAATAT TGTCTGCCTT AAAGCAGTAC CCCCCTACCA CACACACCCC 1020 TGTCCTCCAG CACCATAGAG AGGCGCTAGA GCCCATTCCT CTTTCTCCAC CGTCACCCAA 1080

CATCAATCCT TTACCACTCT ACCAAATAAT TTCATATTCA AGCTTCAGAA GCTAGTGACC 1140

ATCTTCATAA TTTGCTGGAG AAGTGTATTT CTTCCCCTTA CTCTCACACC TGGGCAAACT 1200

TTCTTCAGTG TTTTTCATTT CTTACGTTCT TTCACTTCAA GGGAGAATAT AGAAGCATTT 1260

GATATTATCT ACAAACACTG CAGAACAGCA TCATGTCATA AACGATTCTG AGCCATTCAC 1320 ACTTTTTATT TAATTAAATG TATTTAATTA AATCTCAAAT TTATTTTAAT GTAAAGAACT 1380

TAAATTATGT TTTAAACACA TGCCTTAAAT TTGTTTAATT AAATTTAACT CTGGTTTCTA 1440

CCAGCTCATA CAAAATAAAT GGTTTCTGAA AATGTTTAAG TATTAACTTA CAAGGATATA 1500

GGTTTTTCTC ATGTATCTTT TTGTTCATTG GCAAGATGAA ATAATTTTTC TAGGGTAATG 1560 CCGTAGGAAA AATAAAACTT CACATTTAAA AAAAA

Seq ID NO: 355 Protein sequence Protein Accession ft: NM_002820

1 11 21 31 41 51 I I I I I I

MQRRLVQQWS VAVFLLSYAV PSCGRSVEGL SRRLKRAVSE HQLLHDKGKS IQDLRRRFFL 60 HHLIAEIHTA EIRATSEVSP NSKPSPNTKN HPVRFGSDDE GRYLTQETNK VETYKEQPLK 120 TPGKKKKGKP GKRKEQEKKK RRTRSAWLDS GVTGSGLEGD HLSDTSTTSL ELDSR

Seq ID NO: 356 DNA sequence Nucleic Acid Accession ft: NM_017522 Coding sequence: 1-2100

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ATGGGCCTCC CCGAGCCGGG CCCTCTCCGG CTTCTGGCGC TGCTGCTGCT GCTGCTGCTG 60 CTGCTGCTGC TGCGGCTCCA GCATCTTGCG GCGGCAGCGG CTGATCCGCT GCTCGGCGGC 120

CAAGGGCCGG CCAAGGAGTG CGAAAAGGAC CAATTCCAGT GCCGGAACGA GCGCTGCATC 180

CCCTCTGTGT GGAGATGCGA CGAGGACGAT GACTGCTTAG ACCACAGCGA CGAGGACGAC 240

TGCCCCAAGA AGACCTGTGC AGACAGTGAC TTCACCTGTG ACAACGGCCA CTGCATCCAC 300

GAACGGTGGA AGTGTGACGG CGAGGAGGAG TGTCCTGATG GCTCCGATGA GTCCGAGGCC 360 ACTTGCACCA AGCAGGTGTG TCCTGCAGAG AAGCTGAGCT GTGGACCCAC CAGCCACAAG 420

TGTGTACCTG CCTCGTGGCG CTGCGACGGG GAGAAGGACT GCGAGGGTGG AGCGGATGAG 480

GCCGGCTGTG CTACCTCACT GGGCACCTGC CGTGGGGACG AGTTCCAGTG TGGGGATGGG 540

ACATGTGTCC TTGCAATCAA GCACTGCAAC CAGGAGCAGG ACTGTCCAGA TGGGAGTGAT 600

GAAGCTGGCT GCCTACAGGG GCTGAACGAG TGTCTGCACA ACAATGGCGG CTGCTCACAC 660 ATCTGCACTG ACCTCAAGAT TGGCTTTGAA TGCACGTGCC CAGCAGGCTT CCAGCTCCTG 720

GACCAGAAGA CTTGTGGCGA CATTGATGAG TGCAAGGACC CAGATGCCTG CAGCCAGATC 780

TGTGTCAATT ACAAGGGCTA TTTTAAGTGT GAGTGCTACC CTGGCTGCGA GATGGACCTA 840

CTGACCAAGA ACTGCAAGGC TGCTGCTGGC AAGAGCCCAT CCCTAATCTT CACCAACCGC 900

ACGAGTGCGG AGGATCGACC TGTGAAGCGG AACTATTCAC GCCTCATCCC CATGCTCAAG 960 AATGTCGTGG CACTAGATGT GGAAGTTGCC ACCAATCGCA TCTACTGGTG TGACCTCTCC 1020

TACCGTAAGA TCTATAGCGC CTACATGGAC AAGGCCAGTG ACCCGAAAGA GCGGGAGGTC 1080

CTCATTGACG AGCAGTTGCA CTCTCCAGAG GGCCTGGCAG TGGACTGGGT CCACAAGCAC 1140

ATCTACTGGA CTGACTCGGG CAATAAGACC ATCTCAGTGG CCACAGTTGA TGGTGGCCGC 1200

CGACGCACTC TCTTCAGCCG TAACCTCAGT GAACCCCGGG CCATCGCTGT TGACCCCCTG 1260 CGAGGGTTCA TGTATTGGTC TGACTGGGGG GACCAGGCCA AGATTGAGAA ATCTGGGCTC 1320

AACGGTGTGG ACCGGCAAAC ACTGGTGTCA GACAATATTG AATGGCCCAA CGGAATCACC 1380

CTGGATCTGC TGAGCCAGCG CTTGTACTGG GTAGACTCCA AGCTACACCA ACTGTCCAGC 1440

ATTGACTTCA GTGGAGGCAA CAGAAAGACG CTGATCTCCT CCACTGACTT CCTGAGCCAC 1500

CCTTTTGGGA TAGCTGTGTT TGAGGACAAG GTGTTCTGGA CAGACCTGGA GAACGAGGCC 1560 ATTTTCAGTG CAAATCGGCT CAATGGCCTG GAAATCTCCA TCCTGGCTGA GAACCTCAAC 1620

AACCCACATG ACATTGTCAT CTTCCATGAG CTGAAGCAGC CAAGAGCTCC AGATGCCTGT 1680

GAGCTGAGTG TCCAGCCTAA TGGAGGCTGT GAATACCTGT GCCTTCCTGC TCCTCAGATC 1740

TCCAGCCACT CTCCCAAGTA CACATGTGCC TGTCCTGACA CAATGTGGCT GGGTCCAGAC 1800

ATGAAGAGGT GCTACCGAGA TGCAAATGAA GACAGTAAGA TGGGCTCAAC AGTCACTGCC 1860 GCTGTTATCG GGATCATCGT GCCCATAGTG GTGATAGCCC TCCTGTGCAT GAGTGGATAC 1920

CTGATCTGGA GAAACTGGAA GCGGAAGAAC ACCAAAAGCA TGAATTTTGA CAACCCAGTC 1980

TACAGGAAAA CAACAGAAGA AGAAGATGAA GATGAGCTCC ATATAGGGAG AACTGCTCAG 2040

ATTGGCCATG TCTATCCTGC ACGAGTGGCA TTAAGCCTTG AAGATGATGG ACTACCCTGA 2100

GGATGGGATC ACCCCCTTCG TGCCTCATGG AATTCAGTCC CATGCACTAC ACTCCGGATG 2160 GTGTATGACT GGATGAATGG GTTTCTATAT ATGGGTCTGT GTGAGTGTAT GTGTGTGTGT 2220

GATTTTTTTT TTTAAATTTA TGTTGCGGAA AGGTAACCAC AAAGTTATGA TGAACTGCAA 2280

ACATCCAAAG GATGTGAGAG TTTTTCTATG TATAATGTTT TATACACTTT TTAACTGGTT 2340

GCACTACCCA TGAGGAATTC GTGGAATGGC TACTGCTGAC TAACATGATG CACATAACCA 2400

AATGGGGGCC AATGGCACAG TACCTTACTC ATCATTTAAA AACTATATTT ACAGAAGATG 2460 TTTGGTTGCT GGGGGGCTTT TTTAGGTTTT GGGCATTTGT TTTTTGTAAA TAAGATGATT 2520

ATGCTTTGTG GCTATCCATC AACATAAGT

Seq ID NO: 357 Protein sequence Protein Accession ft: NP_059992

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MGLPEPGPLR LLALLLLLLL LLLLRLQHLA AAAADPLLGG QGPAKECEKD QFQCRNERCI 60

PSVWRCDEDD DCLDHSDEDD CPKKTCADSD FTCDNGHCIH ERWKCDGEEE CPDGSDESEA 120 TCTKQVCPAE KLSCGPTSHK CVPASWRCDG EKDCEGGADE AGCATSLGTC RGDEFQCGDG 180

TCVLAIKHCN QEQDCPDGSD EAGCLQGLNE CLHNNGGCSH ICTDLKIGFE CTCPAGFQLL 240

DQKTCGDIDE CKDPDACSQI CVNYKGYFKC ECYPGCEMDL LTKNCKAAAG KSPSLIFTNR 300

TSAEDRPVKR NYSRLIPMLK NWALDVEVA TNRIYWCDLS YRKIYSAYMD KASDPKEREV 360

LIDEQLHSPE GLAVDWVHKH IYWTDSGNKT ISVATVDGGR RRTLFSRNLS EPRAIAVDPL* 420 RGFMYWSDWG DQAKIEKSGL NGVDRQTLVS DNIEWPNGIT LDLLSQRLYW VDSKLHQLSS 480

IDFSGGNRKT LISSTDFLSH PFGIAVFEDK VFWTDLENEA IFSANRLNGL EISILAENLN 540

NPHDIVIFHE LKQPRAPDAC ELSVQPNGGC EYLCLPAPQI SSHSPKYTCA CPDTMWLGPD 600

MKRCYRDANE DSKMGSTVTA AVIGIIVPIV VIALLCMSGY LIWRNWKRKN TKSMNFDNPV 660

YRKTTEEEDE DELHIGRTAQ IGHVYPARVA LSLEDDGLP

Seq ID NO: 358 DNA sequence Nucleic Acid Accession ft: M27826 Coding sequence: <l-503

1 11 21 31 41 51

A IGCCCAAGAA AICATCTCACC AIATTTCAAAT CITGATCTATT CIGGCTTAGCG AICTGAAGATT 60

GACGCTGCCC GATCGCCTCG GAAGTCCCCT GGACCATCAC AGAAGCCGAG CTTCGGGTAA 120

CTCTCACAGT GGAGGGTAAG TCCATCCCCT GTTTAATCGA TACGGGGGCT ACCCACTCCA 180

CGTTGCCTTC TTTTCAAGGG CCTGTTTCCC TTGCCCCCAT AACTGTTGTG GGTATTGACG 240

GCCAAGCTTC AAAACCCCTG AAAACTCCCC CACTCTGGTG CCAACTTGGA CAACACTCTT 300

TTATGCACTC TTTTTTAGTT ATCCCCACCT GCCCACTTCC CTTATTAGGC CGAAATATTT 360

TAACCAAATT ATCTGCTTCC CTGACTATTC CTGGAGTACA GCTACATCTC ATTGCTGCCC 420

TTCTTCCCAA TCCAAAGCCT CCTTTGTGTC CTCTAACATC CCCACAATAT CAGCCCTTAC 480

CACAAGACCT CCCTTCAGCT TAATCTCTCC CACTCTAGGT TCCCACGCCG CCCCTAATCC 540

CACTTGAAGC AGCCCTGAGA AACATCGCCC ATTCTCTCTC CATACCACCC CCCAAAAATT 600

TTCGCCGCTC CAACACTTCA ACACTATTTT GTTTTATTTG TCTTATTAAT ATCAGAAGGC 660 AGGAATGTCA GGCCTCTGAG CCCAGGCCAG GCCATCGCAT CCCCTGTGAC TTGCACGTAT 720

ACATCCAGAT GGCCTGAAGT AACTGAAGAT CCACAAAAGA AGTAAAAACA GCCTTAACTG 780

ATGACATTCC ACCATTGTGA TTTGTTCCTG CCCCACCCTA ACTGATCAAT GTACTTTGTA 840

ATCTCCCCCA CCCTTAAGAA GGTTCTTTGT AATTCTCCCC ACCCTTGAGA ATGTACTTTG 900

TGAGATCCAC CCCTGCCCAC CAGAGAACAA CCCCCTTTGA TTGTAATTTT TTATTACCTT 960

CCCAAATCCT ATAAAACAGC CCCACCCCTA TCTTCCTTCA CTGACTCTCT TTTCGGACTC 1020 AGCCACCGGC ACCCAGGTGA AATAAACAGC TTTATTGCTC AC

Seq ID NO : 359 Protein sequence Protein Accession ft : AAA65999

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PKKHLTNFKS DLFGLATEDW RCPIASEVPW TITEAELRVT LTVEGKSIPC LIDTGATHST 60 LPSFQGPVSL APITWGIDG QASKPLKTPP LWCQLGQHSF MHSFLVIPTC PLPLLGRNIL 120

TKLSASLTIP GVQLHLIAAL LPNPKPPLCP LTSPQYQPLP QDLPSA

Seq ID NO : 360 DNA sequence Nucleic Acid Accession ft : NM_001854 Coding sequence : 162 -5582

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AACCATCAAA TTTAGAAGAA AAAGCCCTTT GACTTTTTCC CCCTCTCCCT CCCCAATGGC 60

TGTGTAGCAA ACATCCCTGG CGATACCTTG GAAAGGACGA AGTTGGTCTG CAGTCGCAAT 120

TTCGTGGGTT GAGTTCACAG TTGTGAGTGC GGGGCTCGGA GATGGAGCCG TGGTCCTCTA 180

GGTGGAAAAC GAAACGGTGG CTCTGGGATT TCACCGTAAC AACCCTCGCA TTGACCTTCC 240

TCTTCCAAGC TAGAGAGGTC AGAGGAGCTG CTCCAGTTGA TGTACTAAAA GCACTAGATT 300

TTCACAATTC TCCAGAGGGA ATATCAAAAA CAACGGGATT TTGCACAAAC AGAAAGAATT 360 CTAAAGGCTC AGATACTGCT TACAGAGTTT CAAAGCAAGC ACAACTCACT GCCCCAACAA 420

AACAGTTATT TCCAGGTGGA ACTTTCCCAG AAGACTTTTC AATACTATTT ACAGTAAAAC 480

GAAAAAAAGG AATTCAGTCT TTCCTTTTAT CTATATATAA TGAGCATGGT ATTCAGCAAA 540

TTGGTGTTGA GGTTGGGAGA TCACCTGTTT TTCTGTTTGA AGACCACACT GGAAAACCTG 600

CCCCAGAAGA CTATCCCCTC TTCAGAACTG TTAACATCGC TGACGGGAAG TGGCATCGGG 660

TAGCAATCAG CGTGGAGAAG AAAACTGTGA CAATGATTGT TGATTGTAAG AAGAAAACCA 720

CGAAACCACT TGATAGAAGT GAGAGAGCAA TTGTTGATAC CAATGGAATC ACGGTTTTTG 780

GAACAAGGAT TTTGGATGAA GAAGTTTTTG AGGGGGACAT TCAGCAGTTT TTGATCACAG 840

GTGATCCCAA GGCAGCATAT GACTACTGTG AGCATTATAG TCCAGACTGT GACTCTTCAG 900

CACCCAAGGC TGCTCAAGCT CAGGAACCTC AGATAGATGA GTATGCACCA GAGGATATAA 960

TCGAATATGA CTATGAGTAT GGGGAAGCAG AGTATAAAGA GGCTGAAAGT GTAACAGAGG 1020

GACCCACTGT AACTGAGGAG ACAATAGCAC AGACGGAGGC AAACATCGTT GATGATTTTC 1080

AAGAATACAA CTATGGAACA ATGGAAAGTT ACCAGACAGA AGCTCCTAGG CATGTTTCTG 1140

GGACAAATGA GCCAAATCCA GTTGAAGAAA TATTTACTGA AGAATATCTA ACGGGAGAGG 1200

ATTATGATTC CCAGAGGAAA AATTCTGAGG ATACACTATA TGAAAACAAA GAAATAGACG 1260

GCAGGGATTC TGATCTTCTG GTAGATGGAG ATTTAGGCGA ATATGATTTT TATGAATATA 1320

AAGAATATGA AGATAAACCA ACAAGCCCCC CTAATGAAGA ATTTGGTCCA GGTGTACCAG 1380

CAGAAACTGA TATTACAGAA ACAAGCATAA ATGGCCATGG TGCATATGGA GAGAAAGGAC 1440

AGAAAGGAGA ACCAGCAGTG GTTGAGCCTG GTATGCTTGT CGAAGGACCA CCAGGACCAG 1500

CAGGACCTGC AGGTATTATG GGTCCTCCAG GTCTACAAGG CCCCACTGGA CCCCCTGGTG 1560

ACCCTGGGGA TAGGGGCCCC CCAGGACGTC CTGGCTTACC AGGGGCTGAT GGTCTACCTG 1620

GTCCTCCTGG TACTATGTTG ATGTTACCGT TCCGTTATGG TGGTGATGGT TCCAAAGGAC 1680

CAACCATCTC TGCTCAGGAA GCTCAGGCTC AAGCTATTCT TCAGCAGGCT CGGATTGCTC 1740

TGAGAGGCCC ACCTGGCCCA ATGGGTCTAA CTGGAAGACC AGGTCCTGTG GGGGGGCCTG 1800

GTTCATCTGG GGCCAAAGGT GAGAGTGGTG ATCCAGGTCC TCAGGGCCCT CGAGGCGTCC 1860

AGGGTCCCCC TGGTCCAACG GGAAAACCTG GAAAAAGGGG TCGTCCAGGT GCAGATGGAG 1920

GAAGAGGAAT GCCAGGAGAA CCTGGGGCAA AGGGAGATCG AGGGTTTGAT GGACTTCCGG 1980

GTCTGCCAGG TGACAAAGGT CACAGGGGTG AACGAGGTCC TCAAGGTCCT CCAGGTCCTC 2040

CTGGTGATGA TGGAATGAGG GGAGAAGATG GAGAAATTGG ACCAAGAGGT CTTCCAGGTG 2100

AAGCTGGCCC ACGAGGTTTG CTGGGTCCAA GGGGAACTCC AGGAGCTCCA GGGCAGCCTG 2160

GTATGGCAGG TGTAGATGGC CCCCCAGGAC CAAAAGGGAA CATGGGTCCC CAAGGGGAGC 2220

CTGGGCCTCC AGGTCAACAA GGGAATCCAG GACCTCAGGG TCTTCCTGGT CCACAAGGTC 2280

CAATTGGTCC TCCTGGTGAA AAAGGACCAC AAGGAAAACC AGGACTTGCT GGACTTCCTG 2340

GTGCTGATGG GCCTCCTGGT CATCCTGGGA AAGAAGGCCA GTCTGGAGAA AAGGGGGCTC 2400

TGGGTCCCCC TGGTCCACAA GGTCCTATTG GATNNCCGGG CCCCCGGGGA GTAAAGGGAG 2460 CAGATGGTGT CAGAGGTCTC AAGGGATCTA AAGGTGAAAA GGGTGAAGAT GGTTTTCCAG 2520

GATTCAAAGG TGACATGGGT CTAAAAGGTG ACAGAGGAGA AGTTGGTCAA ATTGGCCCAA 2580

GAGGGNAAGA TGGCCCTGAA GGACCCAAAG GTCGAGCAGG CCCAACTGGA GACCCAGGTC 2640

CTTCAGGTCA AGCAGGAGAA AAGGGAAAAC TTGGAGTTCC AGGATTACCA GGATATCCAG 2700

GAAGACAAGG TCCAAAGGGT TCCACTGGAT TCCCTGGGTT TCCAGGTGCC AATGGAGAGA 2760

AAGGTGCACG GGGAGTAGCT GGCAAACCAG GCCCTCGGGG TCAGCGTGGT CCAACGGGTC 2820

CTCGAGGTTC AAGAGGTGCA AGAGGTCCCA CTGGGAAACC TGGGCCAAAG GGCACTTCAG 2880

GTGGCGATGG CCCTCCTGGC CCTCCAGGTG AAAGAGGTCC TCAAGGACCT CAGGGTCCAG 2940

TTGGATTCCC TGGACCAAAA GGCCCTCCTG GACCACCAGG AAGGATGGGC TGCCCAGGAC 3000

ACCCTGGGCA ACGTGGGGAG ACTGGATTTC AAGGCAAGAC CGGCCCTCCT GGGCCAGGGG 3060

GAGTGGTTGG ACCACAGGGA CCAACCGGTG AGACTGGTCC AATAGGGGAA CGTGGGTATC 3120

CTGGTCCTCC TGGCCCTCCT GGTGAGCAAG GTCTTCCTGG TGCTGCAGGA AAAGAAGGTG 3180

CAAAGGGTGA TCCAGGTCCT CAAGGTATCT CAGGGAAAGA TGGACCAGCA GGATTACGTG 3240

GTTTCCCAGG GGAAAGAGGT CTTCCTGGAG CTCAGGGTGC ACCTGGACTG AAAGGAGGGG 3300

AAGGTCCCCA GGGCCCACCA GGTCCAGTTG GCTCACCAGG AGAACGTGGG TCAGCAGGTA 3360

CAGCTGGCCC AATTGGTTTA CGAGGGCGCC CGGGACCTCA GGGTCCTCCT GGTCCAGCTG 3420

GAGAGAAAGG TGCTCCTGGA GAAAAAGGTC CCCAAGGGCC TGCAGGGAGA GATGGAGTTC 3480

AAGGTCCTGT TGGTCTCCCA GGGCCAGCTG GTCCTGCCGG CTCCCCTGGG GAAGACGGAG 3540

ACAAGGGTGA AATTGGTGAG CCGGGACAAA AAGGCAGCAA GGGTGGCAAG GGAGAAAATG 3600

GCCCTCCCGG TCCCCCAGGT CTTCAAGGAC CAGTTGGTGC CCCTGGAATT GCTGGAGGTG 3660

ATGGTGAACC AGGTCCTAGA GGACAGCAGG GGATGTTTGG GCAAAAAGGT GATGAGGGTG 3720

CCAGAGGCTT CCCTGGACCT CCTGGTCCAA TAGGTCTTCA GGCTCTGCCA GGCCCACCTG 3780

GTGAAAAAGG TGAAAATGGG GATGTTGGTC CATGGGGGCC ACCTGGTCCT CCAGGCCCAA 3840 GAGGCCCTCA AGGTCCCAAT GGAGCTGATG GACCACAAGG ACCCCCAGGT TCTGTTGGTT 3900 CAGTTGGTGG TCTTGGAGAA AAGGGTGAAC CTGGAGAAGC AGGAAACCCA GGGCCTCCTG 3960 GGGAAGCAGG TGTAGGCGGT CCCAAAGGAG AAAGAGGAGA GAAAGGGGAA GCTGGTCCAC 4020 CTGGAGCTGC TGGACCTCCA GGTGCCAAGG GGCCGCCAGG TGATGATGGC CCTAAGGGTA 4080 ACCCGGGTCC TGTTGGTTTT CCTGGAGATC CTGGTCCTCC TGGGGAACTT GGCCCTGCAG 4140 GTCAAGATGG TGTTGGTGGT GACAAGGGTG AAGATGGAGA TCCTGGTCAA CCGGGTCCTC 4200 CTGGCCCATC TGGTGAGGCT GGCCCACCAG GTCCTCCTGG AAAACGAGGT CCTCCTGGAG 4260 CTGCAGGTGC AGAGGGAAGA CAAGGTGAAA AAGGTGCTAA GGGGGAAGCA GGTGCAGAAG 4320 GTCCTCCTGG AAAAACCGGC CCAGTCGGTC CTCAGGGACC TGCAGGAAAG CCTGGTCCAG 4380 AAGGTCTTCG GGGCATCCCT GGTCCTGTGG GAGAACAAGG TCTCCCTGGA GCTGCAGGCC 4440 AAGATGGACC ACCTGGTCCT ATGGGACCTC CTGGCTTACC TGGTCTCAAA GGTGACCCTG 4500 GCTCCAAGGG TGAAAAGGGA CATCCTGGTT TAATTGGCCT GATTGGTCCT CCAGGAGAAC 4560 AAGGGGAAAA AGGTGACCGA GGGCTCCCTG GAACTCAAGG ATCTCCAGGA GCAAAAGGGG 4620 ATGGGGGAAT TCCTGGTCCT GCTGGTCCCT TAGGTCCACC TGGTCCTCCA GGCTTACCAG 4680 GTCCTCAAGG CCCAAAGGGT AACAAAGGCT CTACTGGACC CGCTGGCCAG AAAGGTGACA 4740 GTGGTCTTCC AGGGCCTCCT GGGCCTCCAG GTCCACCTGG TGAAGTCATT CAGCCTTTAC 4800 CAATCTTGTC CTCCAAAAAA ACGAGAAGAC ATACTGAAGG CATGCAAGCA GATGCAGATG 4860 ATAATATTCT TGATTACTCG GATGGAATGG AAGAAATATT TGGTTCCCTC AATTCCCTGA 4920 AACAAGACAT CGAGCATATG AAATTTCCAA TGGGTACTCA GACCAATCCA GCCCGAACTT 4980 GTAAAGACCT GCAACTCAGC CATCCTGACT TCCCAGATGG TGAATATTGG ATTGATCCTA 5040 ACCAAGGTTG CTCAGGAGAT TCCTTCAAAG TTTACTGTAA TTTCACATCT GGTGGTGAGA 5100 CTTGCATTTA TCCAGACAAA AAATCTGAGG GAGTAAGAAT TTCATCATGG CCAAAGGAGA 5160 AACCAGGAAG TTGGTTTAGT GAATTTAAGA GGGGAAAACT GCTTTCATAC TTAGATGTTG 5220 AAGGAAATTC CATCAATATG GTGCAAATGA CATTCCTGAA ACTTCTGACT GCCTCTGCTC 5280 GGCAAAATTT CACCTACCAC TGTCATCAGT CAGCAGCCTG GTATGATGTG TCATCAGGAA 5340 GTTATGACAA AGCACTTCGC TTCCTGGGAT CAAATGATGA GGAGATGTCC TATGACAATA 5400 ATCCTTTTAT CAAAACACTG TATGATGGTT GTACGTCCAG AAAAGGCTAT GAAAAAACTG 5460 TCATTGAAAT CAATACACCA AAAATTGATC AAGTACCTAT TGTTGATGTC ATGATCAGTG 5520 ACTTTGGTGA TCAGAATCAG AAGTTCGGAT TTGAAGTTGG TCCTGTTTGT TTTCTTGGCT 5580 AAGATTAAGA CAAAGAACAT ATCAAATCAA CAGAAAATGT ACCTTGGTGC CACCAACCCA 5640 TTTTGTGCCA CATGCAAGTT TTGAATAAGG ATGTATGGAA AACAACGCTG CATATACAGG 5700 TACCATTTAG GAAATACCGA TGCCTTTGTG GGGGCAGAAT CACAGACAAA AGCTTTGAAA 5760 ATCATAAAGA TATAAGTTGG TGTGGCTAAG ATGGAAACAG GGCTGATTCT TGATTCCCAA 5820 TTCTCAACTC TCCTTTTCCT ATTTGAATTT CTTTGGTGCT GTAGAAAACA AAAAAAGAAA 5880 AATATATATT CATAAAAAAT ATGGTGCTCA TTCTCATCCA TCCAGGATGT ACTAAAACAG 5940 TGTGTTTAAT AAATTGTAAT TATTTTGTGT ACAGTTCTAT ACTGTTATCT GTGTCCATTT 6000 CCAAAACTTG CACGTGTCCC TGAATTCCGC TGACTCTAAT TTATGAGGAT GCCGAACTCT 6060 GATGGCAATA ATATATGTAT TATGAAAATG AAGTTATGAT TTCCGATGAC CCTAAGTCCC 6120 TTTCTTTGGT TAATGATGAA ATTCCTTTGT GTGTGTTT

Seq ID NO: 361 Protein sequence Protein Accession ft: NP 001845

11 21 31 41 51

MEPWSSRWKT K IRWLWDFTVT TLALTFLFQA REVRGAAPVD VLKALDFHNS P IEGISKTTGF 60 CTNRKNSKGS DTAYRVSKQA QLSAPTKQLF PGGTFPEDFS ILFTVKPKKG IQSFLLSIYN 120 EHGIQQIGVE VGRSPVFLFE DHTGKPAPED YPLFRTVNIA DGKWHRVAIS VEKKTVTMIV 180 DCKKKTTKPL DRSERAIVDT NGITVFGTRI LDEEVFEGDI QQFLITGDPK AAYDYCEHYS 240 PDCDSSAPKA AQAQEPQIDE YAPEDIIEYD YEYGEAEYKE AESVTEGPTV TEETIAQTEA 300 NIVDDFQEYN YGTMESYQTE APRHVSGTNE PNPVEEIFTE EYLTGEDYDS QRKNSEDTLY 360 ENKEIDGRDS DLLVDGDLGE YDFYEYKEYE DKPTSPPNEE FGPGVPAETD ITETSINGHG 420 AYGEKGQKGE PAWEPGMLV EGPPGPAGPA GIMGPPGLQG PTGPPGDPGD RGPPGRPGLP 480 GADGLPGPPG TMLMLPFRYG GDGSKGPTIS AQEAQAQAIL QQARIALRGP PGPMGLTGRP 540 GPVGGPGSSG AKGESGDPGP QGPRGVQGPP GPTGKPGKRG RPGADGGRGM PGEPGAKGDR 600 GFDGLPGLPG DKGHRGERGP QGPPGPPGDD GMRGEDGEIG PRGLPGEAGP RGLLGPRGTP 660 GAPGQPGMAG VDGPPGPKGN MGPQGEPGPP GQQGNPGPQG LPGPQGPIGP PGEKGPQGKP 720 GLAGLPGADG PPGHPGKEGQ SGEKGALGPP GPQGPIGXPG PRGVKGADGV RGLKGSKGEK 780 GEDGFPGFKG DMGLKGDRGE VGQIGPRGXD GPEGPKGRAG PTGDPGPSGQ AGEKGKLGVP 840 GLPGYPGRQG PKGSTGFPGF PGANGEKGAR GVAGKPGPRG QRGPTGPRGS RGARGPTGKP 900 GPKGTSGGDG PPGPPGERGP QGPQGPVGFP GPKGPPGPPG RMGCPGHPGQ RGETGFQGKT 960 GPPGPGGWG PQGPTGETGP IGERGYPGPP GPPGEQGLPG AAGKEGAKGD PGPQGISGKD 1020 GPAGLRGFPG ERGLPGAQGA PGLKGGEGPQ GPPGPVGSPG ERGSAGTAGP IGLRGRPGPQ 1080 GPPGPAGEKG APGEKGPQGP AGRDGVQGPV GLPGPAGPAG SPGEDGDKGE IGEPGQKGSK 1140 GGKGENGPPG PPGLQGPVGA PGIAGGDGEP GPRGQQGMFG QKGDEGARGF PGPPGPIGLQ 1200 GLPGPPGEKG ENGDVGPWGP PGPPGPRGPQ GPNGADGPQG PPGSVGSVGG VGEKGEPGEA 1260 GNPGPPGEAG VGGPKGERGE KGEAGPPGAA GPPGAKGPPG DDGPKGNPGP VGFPGDPGPP 1320 GELGPAGQDG VGGDKGEDGD PGQPGPPGPS GEAGPPGPPG KRGPPGAAGA EGRQGEKGAK 1380 GEAGAEGPPG KTGPVGPQGP AGKPGPEGLR GIPGPVGEQG LPGAAGQDGP PGPMGPPGLP 1440 GLKGDPGSKG EKGHPGLIGL IGPPGEQGEK GDRGLPGTQG SPGAKGDGGI PGPAGPLGPP 1500 GPPGLPGPQG PKGNKGSTGP AGQKGDSGLP GPPGPPGPPG EVIQPLPILS SKKTRRHTEG 1560 MQADADDNIL DYSDGMEEIF GSLNSLKQDI EHMKFPMGTQ TNPARTCKDL QLSHPDFPDG 1620 EYWIDPNQGC SGDSFKVYCN FTSGGETCIY PDKKSEGVRI SSWPKEKPGS WFSEFKRGKL 1680 LSYLDVEGNS INMVQMTPLK LLTASARQNF TYHCHQSAAW YDVSSGSYDK ALRFLGSNDE 1740 EMSYDNNPFI KTLYDGCTSR KGYEKTVIEI NTPKIDQVPI VDVMISDFGD QNQKFGFEVG 1800 PVCFLG

Seq ID NO: 362 DNA sequence Nucleic Acid Accession ft: NM_003107 Coding sequence: 351-1775

1 11 21 31 41 51

I I I I I I

TTCCCCAGCA TTCGAGAAAC TCCTCTCTAC TTTAGCACGG TCTCCAGACT CAGCCGAGAG 60 ACAGCAAACT GCAGCGCGGT GAGAGAGCGA GAGAGAGGGA GAGAGAGACT CTCCAGCCTG 120 GGAACTATAA CTCCTCTGCG AGAGGCGGAG AACTCCTTCC CCAAATCTTT TGGGGACTTT 180 TCTCTCTTTA CCCACCTCCG CCCCTGCGAG GAGTTGAGGG GCCAGTTCGG CCGCCGCGCG 240

CGTCTTCCCG TTCGGCGTGT GCTTGGCCCG GGGAACCGGG AGGGCCCGGC GATCGCGCGG 300

CGGCCGCCGC GAGGGTGTGA GCGCGCGTGG GCGCCCGCCG AGCCGAGGCC ATGGTGCAGC 360

AAACCAACAA TGCCGAGAAC ACGGAAGCGC TGCTGGCCGG CGAGAGCTCG GACTCGGGCG 420

CCGGCCTCGA GCTGGGAATC GCCTCCTCCC CCACGCCCGG CTCCACCGCC TCCACGGGCG 480

GCAAGGCCGA CGACCCGAGC TGGTGCAAGA CCCCGAGTGG GCACATCAAG CGACCCATGA 540

ACGCCTTCAT GGTGTGGTCG CAGATCGAGC GGCGCAAGAT CATGGAGCAG TCGCCCGACA 600

TGCACAACGC CGAGATCTCC AAGCGGCTGG GCAAACGCTG GAAGCTGCTC AAAGACAGCG 660

ACAAGATCCC TTTCATTCGA GAGGCGGAGC GGCTGCGCCT CAAGCACATG GCTGACTACC 720

CCGACTACAA GTACCGGCCC AGGAAGAAGG TGAAGTCCGG CAACGCCAAC TCCAGCTCCT 780

CGGCCGCCGC CTCCTCCAAG CCGGGGGAGA AGGGAGACAA GGTCGGTGGC AGTGGCGGGG 840

GCGGCCATGG GGGCGGCGGC GGCGGCGGGA GCAGCAACGC GGGGGGAGGA GGCGGCGGTG 900

CGAGTGGCGG CGGCGCCAAC TCCAAACCGG CGCAGAAAAA GAGCTGCGGC TCCAAAGTGG 960

CGGGCGGCGC GGGCGGTGGG GTTAGCAAAC CGCACGCCAA GCTCATCCTG GCAGGCGGCG 1020

GCGGCGGCGG GAAAGCAGCG GCTGCCGCCG CCGCCTCCTT CGCCGCCGAA CAGGCGGGGG 1080

CCGCCGCCCT GCTGCCCCTG GGCGCCGCCG CCGACCACCA CTCGCTGTAC AAGGCGCGGA 1140

CTCCCAGCGC CTCGGCCTCC GCCTCCTCGG CAGCCTCGGC CTCCGCAGCG CTCGCGGCCC 1200

CGGGCAAGCA CCTGGCGGAG AAGAAGGTGA AGCGCGTCTA CCTGTTCGGC GGCCTGGGCA 1260

CGTCGTCGTC GCCCGTGGGC GGCGTGGGCG CGGGAGCCGA CCCCAGCGAC CCCCTGGGCC 1320

TGTACGAGGA GGAGGGCGCG GGCTGCTCGC CCGACGCGCC CAGCCTGAGC GGCCGCAGCA 1380

GCGCCGCCTC GTCCCCCGCC GCCGGCCGCT CGCCCGCCGA CCACCGCGGC TACGCCAGCC 1440

TGCGCGCCGC CTCGCCCGCC CCGTCCAGCG CGCCCTCGCA CGCGTCCTCC TCGGCCTCGT 1500

CCCACTCCTC CTCTTCCTCC TCCTCGGGCT CCTCGTCCTC CGACGACGAG TTCGAAGACG 1560

ACCTGCTCGA CCTGAACCCC AGCTCAAACT TTGAGAGCAT GTCCCTGGGC AGCTTCAGTT 1620

CGTCGTCGGC GCTCGACCGG GACCTGGATT TTAACTTCGA GCCCGGCTCC GGCTCGCACT 1680

TCGAGTTCCC GGACTACTGC ACGCCCGAGG TGAGCGAGAT GATCTCGGGA GACTGGCTCG 1740

AGTCCAGCAT CTGCAACCTG GTTTTCACCT ACTGAAGGGC GCGCAGGCAG GGAGAAGGGC 1800

CGGGGGGGGT AGGAGAGGAG^"AAAAAAAAAG TGAAAAAAAG AAACGAAAAG GACAGACGAA 1860

GAGTTTAAAG AGAAAAGGGA AAAAAGAAAG AAAAAGTAAG CAGGGCTCGT TCGCCCGCGT 1920

TCTCGTCGTC GGATCAAGGA GCGCGGCGGC GTTTTGGACC CGCGCTCCCA TCCCCCACCT 1980

TCCCGGGCCG GGGACCCACT CTGCCCAGCC GGAGGGACGC GGAGGAGGAA GAGGGTAGAC 2040

AGGGGCGACC TGTGATTGTT GTTATTGATG TTGTTGTTGA TGGCAAAAAA AAAAAGCGAC 2100

TTCGAGTTTG CTCCCCTTTG CTTGAAGAGA CCCCCTCCCC CTTCCAACGA GCTTCCGGAC 2160

TTGTCTGCAC CCCCAGCAAG AAGGCGAGTT AGTTTTCTAG AGACTTGAAG GAGTCTCCCC 2220

CTTCCTGCAT CACCACCTTG GTTTTGTTTT ATTTTGCTTC TTGGTCAAGA AAGGAGGGGA 2280

GAACCCAGCG CACCCCTCCC CCCCTTTTTT TAAACGCGTG ATGAAGACAG AAGGCTCCGG 2340

GGTGACGAAT TTGGCCGATG GCAGATGTTT TGGGGGAACG CCGGGACTGA GAGACTCCAC 2400

GCAGGCGAAT TCCCGTTTGG GGCCTTTTTT TCCTCCCTCT TTTCCCCTTG CCCCCTCTGC 2460

AGCCGGAGGA GGAGATGTTG AGGGGAGGAG GCCAGCCAGT GTGACCGGCG CTAGGAAATG 2520

ACCCGAGAAC CCCGTTGGAA GCGCAGCAGC GGGAGCTAGG GGCGGGGGCG GAGGAGGACA 2580

CGAACTGGAA GGGGGTTCAC GGTCAAACTG AAATGGATTT GCACGTTGGG GAGCTGGCGG 2640

CGGCGGCTGC TGGGCCTCCG CCTTCTTTTC TACGTGAAAT CAGTGAGGTG AGACTTCCCA 2700

GACCCCGGAG GCGTGGAGGA GAGGAGACTG TTTGATGTGG TACAGGGGCA GTCAGTGGAG 2760 GGCGAGTGGT TTCGGAAAAA AAAAAAGAAA AAAAGGG

Seq ID NO: 363 Protein sequence Protein Accession ft: NP 003098 1 11 21 31 41 51 i i I ^' I I I

MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS WCKTPSGHIK 60

RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL KDSDKIPFIR EAERLRLKHM 120

ADYPDYKYRP RKKVKSGNAN SSSSAAASSK PGEKGDKVGG SGGGGHGGGG GGGSSNAGGG 180

GGGASGGGAN SKPAQKKSCG SKVAGGAGGG VSKPHAKLIL AGGGGGGKAA AAAAASFAAE 240 QAGAAALLPL GAAADHHSLY KARTPSASAS ASSAASASAA LAAPGKHLAE KKVKRVYLFG 300

GLGTSSSPVG GVGAGADPSD PLGLYEEEGA GCSPDAPSLS GRSSAASSPA AGRSPADHRG 360

YASLRAASPA PSSAPSHASS SASSHSSSSS SSGSSSSDDE FEDDLLDLNP SSNFESMSLG 420 SFSSSSALDR DLDFNFEPGS GSHFEFPDYC TPEVSEMISG DWLESSISNL VFTY

Seq ID NO: 364 DNA sequence Nucleic Acid Accession ft: U10860 Coding sequence: 123-2204

1 11 21 31 41 51

I I I I I I

TGCCGGCTGC TCCTCGACCA GGCCTCCTTC TCAACCTCAG CCCGCGGCGC CGACCCTTCC 60

GGCACCCTCC CGCCCCGTCT CGTACTGTCG CCGTCACCGC CGCGGCTCCG GCCCTGGCCC 120

CGATGGCTCT GTGCAACGGA GACTCCAAGC TGGAGAATGC TGGAGGAGAC CTTAAGGATG 180

GCCACCACCA CTATGAAGGA GCTGTTGTCA TTCTGGATGC TGGTGCTCAG TACGGGAAAG 240

TCATAGACCG AAGAGTGAGG GAACTGTTCG TGCAGTCTGA AATTTTCCCC TTGGAAACAC 300

CAGCATTTGC TATAAAGGAA CAAGGATTCC GTGCTATTAT CATCTCTGGA GGACCTAATT 360

CTGTGTATGC TGAAGATGCT CCCTGGTTTG ATCCAGCAAT ATTCACTATT GGCAAGCCTG 420

TTCTTGGAAT TTGCTATGGT ATGCAGATGA TGAATAAGGT ATTTGGAGGT ACTGTGCACA 480

AAAAAAGTGT CAGAGAAGAT GGAGTTTTCA ACATTAGTGT GGATAATACA TGTTCATTAT 540

TCAGGGGCCT TCAGAAGGAA GAAGTTGTTT TGCTTACACA TGGAGATAGT GTAGACAAAG 600

TAGCTGATGG ATTCAAGGTT GTGGCACGTT CTGGAAACAT AGTAGCAGGC ATAGCAAATG 660

AATCTAAAAA GTTATATGGA GCACAGTTCC ACCCTGAAGT TGGCCTTACA GAAAATGGAA 720

AAGTAATACT GAAGAATTTC CTTTATGATA TAGCTGGATG CAGTGGAACC TTCACCGTGC 780

AGAACAGAGA ACTTGAGTGT ATTCGAGAGA TCAAAGAGAG AGTAGGCACG TCAAAAGTTT 840

TGGTTTTACT CAGTGGTGGA GTAGACTCAA CAGTTTGTAC AGCTTTGCTA AATCGTGCTT 900

TGAACCAAGA ACAAGTCATT GCTGTGCACA TTGATAATGG CTTTATGAGA AAACGAGAAA 960

GCCAGTCTGT TGAAGAGGCC CTCAAAAAGC TTGGAATTCA GGTCAAAGTG ATAAATGCTG 1020

CTCATTCTTT CTACAATGGA ACAACAACCC TACCAATATC AGATGAAGAT AGAACCCCAC 1080

GGAAAAGAAT TAGCAAAACG TTAAATATGA CCACAAGTCC TGAAGAGAAA AGAAAAATCA 1140

TTGGGGATAC TTTTGTTAAG ATTGCCAATG AAGTAATTGG AGAAATGAAC TTGAAACCAG 1200

AGGAGGTTTT CCTTGCCCAA GGTACTTTAC GGCCTGATCT AATTGAAAGT GCATCCCTTG 1260 TTGCAAGTGG CAAAGCTGAA CTCATCAAAA CCCATCACAA TGACACAGAG CTCATCAGAA 1320

AGTTGAGAGA GGAGGGAAAA GTAATAGAAC CTCTGAAAGA TTTTCATAAA GATGAAGTGA 1380

GAATTTTGGG CAGAGAACTT GGACTTCCAG AAGAGTTAGT TTCCAGGCAT CCATTTCCAG 1440

GTCCTGGCCT GGCAATCAGA GTAATATGTG CTGAAGAACC TTATATTTGT AAGGACTTTC 1500

CTGAAACCAA CAATATTTTG AAAATAGTAG CTGATTTTTC TGCAAGTGTT AAAAAGCCAC 1560

ATACCCTATT ACAGAGAGTC AAAGCCTGCA CAACAGAAGA GGATCAGGAG AAGCTGATGC 1620

AAATTACCAG TCTGCATTCA CTGAATGCCT TCTTGCTGCC AATTAAAACT GTAGGTGTGC 1680

AGGGTGACTG TCGTTCCTAC AGTTACGTGT GTGGAATCTC CAGTAAAGAT GAACCTGACT 1740

GGGAATCACT TATTTTTCTG GCTAGGCTTA TACCTCGCAT GTGTCACAAC GTTAACAGAG 1800

TTGTTTATAT ATTTGGCCCA CCAGTTAAAG AACCTCCTAC AGATGTTACT CCCACTTTCT 1860

TGACAACAGG GGTGCTCAGT ACTTTACGCC AAGCTGATTT TGAGGCCCAT AACATTCTCA 1920

GGGAGTCTGG GTATGCTGGG AAAATCAGCG AGATGCCGGT GATTTTGACA CCATTACATT 1980

TTGATCGGGA CCCACTTCAA AAGCAGCCTT CATGCCAGAG ATCTGTGGTT ATTCGAACCT 2040

TTATTACTAG TGACTTCATG ACTGGTATAC CTGCAACACC TGGCAATGAG ATCCCTGTAG 2100

AGGTGGTATT AAAGATGGTC ACTGAGATTA AGAAGATTCC TGGTATTTCT CGAATTATGT 2160 ATGACTTAAC ATCAAAGCCC CCAGGAACTA CTGAGTGGGA GTAATAAACT TC

Seq ID NO: 365 Protein sequence Protein Accession ft: AAA60331

41 51

MALCNGDSKL ENAGGDLKDG HHHYEGAWI LDAGAQYGKV IDRRVRELFV QSEIFPLETP 60

AFAIKEQGFR AIIISGGPNS VYAEDAPWPD PAIFTIGKPV LGICYGMQMM NKVFGGTVHK 120

KSVREDGVFN ISVDNTCSLF RGLQKEEWL LTHGDSVDKV ADGFKWARS GNIVAGIANE 180

SKKLYGAQFH PEVGLTENGK VILKNFLYDI AGCSGTFTVQ NRELECIREI KERVGTSKVL 240

VLLSGGVDST VCTALLNRAL NQEQVIAVHI DNGFMRKRES QSVEEALKKL GIQVKVINAA 300

HSFYNGTTTL PISDEDRTPR KRISKTLNMT TSPEEKRKII GDTFVKIANE VIGEMNLKPE 360

EVFLAQGTLR PDLIESASLV ASGKAELIKT HHNDTE IRK LREEGKVIEP LKDFHKDEVR 420

ILGRELGLPE ELVSRHPFPG PGLAIRVICA EEPYICKDFP ETNNILKIVA DFSASVKKPH 480

TLLQRVKACT TEEDQEKLMQ ITSLHSLNAF LLPIKTVGVQ GDCRSYSYVC GISSKDEPDW 540

ESLIFLARLI PRMCHNVNRV VYIFGPPVKE PPTDVTPTFL TTGVLSTLRQ ADFEAHNILR 600

ESGYAGKISQ MPVILTPLHF DRDPLQKQPS CQRSWIRTF ITSDFMTGIP ATPGNEIPVE 660

WLKMVTEIK KIPGISRIMY DLTSKPPGTT EWE

Seq ID NO: 366 DNA sequence Nucleic Acid Accession ft: NM_004219 Coding sequence: 46-654

11 21 31 41 51

GCGGCCTCAG ATGAATGCGG CTGTTAAGAC CTGCAATAAT CCAGAATGGC TACTCTGATC 60 TATGTTGATA AGGAAAATGG AGAACCAGGC ACCCGTGTGG TTGCTAAGGA TGGGCTGAAG 120 CTGGGGTCTG GACCTTCAAT CAAAGCCTTA GATGGGAGAT CTCAAGTTTC AACACCACGT 180 TTTGGCAAAA CGTTCGATGC CCCACCAGCC TTACCTAAAG CTACTAGAAA GGCTTTGGGA 240 ACTGTCAACA GAGCTACAGA AAAGTCTGTA AAGACCAAGG GACCCCTCAA ACAAAAACAG 300 CCAAGCTTTT CTGCCAAAAA GATGACTGAG AAGACTGTTA AAGCAAAAAG CTCTGTTCCT 360 GCCTCAGATG ATGCCTATCC AGAAATAGAA AAATTCTTTC CCTTCAATCC TCTAGACTTT 420 GAGAGTTTTG ACCTGCCTGA AGAGCACCAG ATTGCGCACC TCCCCTTGAG TGGAGTGCCT 480 CTCATGATCC TTGACGAGGA GAGAGAGCTT GAAAAGCTGT TTCAGCTGGG CCCCCCTTCA 540 CCTGTGAAGA TGCCCTCTCC ACCATGGGAA TCCAATCTGT TGCAGTCTCC TTCAAGCATT 600 CTGTCGACCC TGGATGTTGA ATTGCCACCT GTTTGCTGTG ACATAGATAT TTAAATTTCT 660 TAGTGCTTCA GAGTTTGTGT GTATTTGTAT TAATAAAGCA TTCTTCAACA GAAAAAAAAA 720 AAAAAAAA

Seq ID NO: 367 Protein sequence Protein Accession ft: NP 004210

11 21 31 41 51

MATLIYVDKE NGEPGTRWA KDGLKLGSGP SIKALDGRSQ VSTPRFGKTF DAPPALPKAT 60

RKALGTVNRA TEKSVKTKGP LKQKQPSFSA KKMTEKTVKA KSSVPASDDA YPEIEKFFPF 120

NPLDFESFDL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPSPVKMP SPPWESNLLQ 180 SPSSILSTLD VELPPVCCDI DI

Seq ID NO: 368 DNA sequence Nucleic Acid Accession ft: NM_000597 Coding sequence: 118-1104

11 21 31 41 51

ATTCGGGGCG AGGGAGGAGG AAGAAGCGGA GGAGGCGGCT CCCGCTCGCA GGGCCGTGCA 60 CCTGCCCGCC CGCCCGCTCG CTCGCTCGCC CGCCGCGCCG CGCTGCCGAC CGCCAGCATG 120 CTGCCGAGAG TGGGCTGCCC CGCGCTGCCG CTGCCGCCGC CGCCGCTGCT GCCGCTGCTG 180 CCGCTGCTGC TGCTGCTACT GGGCGCGAGT GGCGGCGGCG GCGGGGCGCG CGCGGAGGTG 240 CTGTTCCGCT GCCCGCCCTG CACACCCGAG CGCCTGGCCG CCTGCGGGCC CCCGCCGGTT 300 GCGCCGCCCG CCGCGGTGGC CGCAGTGGCC GGAGGCGCCC GCATGCCATG CGCGGAGCTC 360 GTCCGGGAGC CGGGCTGCGG CTGCTGCTCG GTGTGCGCCC GGCTGGAGGG CGAGGCGTGC 420 GGCGTCTACA CCCCGCGCTG CGGCCAGGGG CTGCGCTGCT ATCCCCACCC GGGCTCCGAG 480 CTGCCCCTGC AGGCGCTGGT CATGGGCGAG GGCACTTGTG AGAAGCGCCG GGACGCCGAG 540 TATGGCGCCA GCCCGGAGCA GGTTGCAGAC AATGGCGATβ ACCACTCAGA AGGAGGCCTG 600 GTGGAGAACC ACGTGGACAG CACCATGAAC ATGTTGGGCG GGGGAGGCAG TGCTGGCCGG 660 AAGCCCCTCA AGTCGGGTAT GAAGGAGCTG GCCGTGTTCC GGGAGAAGGT CACTGAGCAG 720 CACCGGCAGA TGGGCAAGGG TGGCAAGCAT CACCTTGGCC TGGAGGAGCC CAAGAAGCTG 780 CGACCACCCC CTGCCAGGAC TCCCTGCCAA CAGGAACTGG ACCAGGTCCT GGAGCGGATC 840 TCCACCATGC GCCTTCCGGA TGAGCGGGGC CCTCTGGAGC ACCTCTACTC CCTGCACATC 900

CCCAACTGTG ACAAGCATGG CCTGTACAAC CTCAAACAGT GCAAGATGTC TCTGAACGGG 960

CAGCGTGGGG AGTGCTGGTG TGTGAACCCC AACACCGGGA AGCTGATCCA GGGAGCCCCC 1020

ACCATCCGGG GGGACCCCGA GTGTCATCTC TTCTACAATG AGCAGCAGGA GGCTTGCGGG 1080

GTGCACACCC AGCGGATGCA GTAGACCGCA GCCAGCCGGT GCCTGGCGCC CCTGCCCCCC 1140

GCCCCTCTCC AAACACCGGC AGAAAACGGA GAGTGCTTGG GTGGTGGGTG CTGGAGGATT 1200

TTCCAGTTCT GACACACGTA TTTATATTTG GAAAGAGACC AGCACCGAGC TCGGCACCTC 1260

CCCGGCCTCT CTCTTCCCAG CTGCAGATGC CACACCTGCT CCTTCTTGCT TTCCCCGGGG 1320

GAGGAAGGGG GTTGTGGTCG GGGAGCTGGG GTACAGGTTT GGGGAGGGGG AAGAGAAATT 1380 TTTATTTTTG AACCCCTGTG TCCCTTTTGC ATAAGATTAA AGGAAGGAAA AGT

Seq ID NO: 369 Prote sequence Protein Accession ft: NP_000588

1 11 21 31 41 51

I I I I I I

MLPRVGCPAL PLPPPPLLPL LPLLLLLLGA SGGGGGARAE VLFRCPPCTP ERLAACGPPP 60

VAPPAAVAAV AGGARMPCAE LVREPGCGCC SVCARLEGEA CGVYTPRCGQ GLRCYPHPGS 120

ELPLQALVMG EGTCEKRRDA EYGASPEQVA DNGDDHSEGG LVENHVDSTM NMLGGGGSAG 180

RKPLKSGMKE LAVPREKVTE QHRQMGKGGK HHLGLEEPKK LRPPPARTPC QQELDQVLER 240

ISTMRLPDER GPLEHLYSLH IPNCDKHGLY NLKQCKMSLN GQRGECWCVN PNTGKLIQGA 300 PTIRGDPECH LFYNEQQEAC GVHTQRMQ

Seq ID NO: 370 DNA sequence Nucleic Acid Accession ft: NM 004264

Coding sequence: 6-440

1 11 21 31 41 51

I I I I I I

GGAACATGGC GGATCGGCTC ACGCAGCTTC AGGACGCTGT GAATTCGCTT GCAGATCAGT 60

TTTGTAATGC CATTGGAGTA TTGCAGCAAT GTGGTCCTCC TGCCTCTTTC AATAATATTC 120

AGACAGCAAT TAACAAAGAC CAGCCAGCTA ACCCTACAGA AGAGTATGCC CAGCTTTTTG 180

CAGCACTGAT TGCACGAACA GCAAAAGACA TTGATGTTTT GATAGATTCC TTACCCAGTG 240

AAGAATCTAC AGCTGCTTTA CAGGCTGCTA GCTTGTATAA GCTAGAAGAA GAAAACCATG 300

AAGCTGCTAC ATGTGTGGAG GATGTTGTTT ATCGAGGAGA CATGCTTCTG GAGAAGATAC 360

AAAGCGCACT TGCTGATATT GCACAGTCAC AGCTGAAGAC AAGAAGTGGT ACCCATAGCC 420

AGTCTCTTCC AGACTCATAG CATCAGTGGA TACCATGTGG CTGAGAAAAG AACTGTTTGA 480

GTGCCATTAA GAATTCTGCA TCAGACTTAG ATACAAGCCT TACCAACAAT TACAGAAACA 540

TTAAACACTA TGACACATTA CCTTTTTAGC TATTTTTAAT AGTCTTCTAT TTTCACTCTT 600

GATAAGCTTA TAAATCATGA TTGAATCAGC TTTAAAGCAT CATACCATCA TTTTTTAACT 660

GAGTGAAATT ATTAAGGCAT GTAATACATT AATGAACATA ATATAAGGAA ACATATGTAA 720

AATTCTGTTA TGACATAATT TATGTCTCCA TTTTGTTGTA TTGGCCAGTA CTTTTACAAT 780 C

Seq ID NO: 371 Protein sequence Protem Accession ft : NP_004255

1 11 21 31 41 51

I I I I I I

MADRLTQLQD AVNSLADQFC NAIGVLQQCG PPASFNNIQT AINKDQPANP TEEYAQLFAA 60 LIARTAKDID VLIDSLPSEE STAALQAASL YKLEEENHEA ATCVEDWYR GDMLLEKIQS 120 ALADIAQSQL KTRSGTHSQS LPDS

Seq ID NO: 372 DNA sequence Nucleic Acid Accession ft: AJ271091 Coding sequence: 1-1113

1 11 21 31 41 51

I I I I I I

ATGGAGAATC AGGTGTTGAC GCCGCATGTC TACTGGGCTC AGCGACACCG CGAGCTATAT 60

CTGCGCGTGG AGCTGAGTGA CGTACAGAAC CCTGCCATCA GCATCACTGA AAACGTGCTG 120

CATTTCAAAG CTCAAGGACA TGGTGCCAAA GGAGACAATG TCTATGAATT TCACCTGGAG 180

TTCTTAGACC TTGTGAAACC AGAGCCTGTT TACAAACTGA CCCAGAGGCA GGTAAACATT 240

ACAGTACAGA AGAAAGTGAG TCAGTGGTGG GAGAGACTCA CAAAGCAGGA AAAGCGACCA 300

CTGTTTTTGG CTCCTGACTT TGATCGTTGG CTGGATGAAT CTGATGCGGA AATGGAGCTC 360

AGAGCTAAGG AAGAAGAGCG CCTAAATAAA CTCCGACTGG AAAGCGAAGG CTCTCCTGAA 420

ACTCTTACAA ACTTAAGGAA AGGATACCTG TTTATGTATA ATCTTGTGCA ATTCTTGGGA 480

TTCTCCTGGA TCTTTGTCAA CCTGACTGTG CGATTCTGTA TCTTGGGAAA AGAGTCCTTT 540

TATGACACAT TCCATACTGT GGCTGACATG ATGTATTTCT GCCAGATGCT GGCAGTTGTG 600

GAAACTATCA ATGCAGCAAT TGGAGTCACT ACGTCACCGG TGCTGCCTTC TCTGATCCAG 660

CTTCTTGGAA GAAATTTTAT TTTGTTTATC ATCTTTGGCA CCATGGAAGA AATGCAGAAC 720

AAAGCTGTGG TTTTCTTTGT GTTTTATTTG TGGAGTGCAA TTGAAATTTT CAGGTACTCT 780

TTCTACATGC TGACGTGCAT TGACATGGAT TGGAAGGTGC TCACATGGCT TCGTTACACT 840

CTGTGGATTC CCTTATATCC ACTGGGATGT TTGGCGGAAG CTGTCTCAGT GATTCAGTCC 900

ATTCCAATAT TCAATGAGAC CGGACGATTC AGTTTCACAT TGCCATATCC AGTGAAAATC 960

AAAGTTAGAT TTTCCTTTTT TCTTCAGATT TATCTTATAA TGATATTTTT AGGTTTATAC 1020

ATAAATTTTC GTCACCTTTA TAAACAGCGC AGACTGAAAA TGAGGGCAGG CGCAGTGGCT 1080 CATGCCTGTG ATCCCAGCGC TTTGGGAGGC TGA

Seq ID NO: 373 Protein sequence Protein Accession ft: CAB69070

1 11 21 31 41 51

M IENQVLTPHV YIWAQRHRELY LIRVELSDVQN PIAISITENVL HIFKAQGHGAK GIDNVYEFHLE 60

FLDLVKPEPV YKLTQRQVNI TVQKKVSQWW ERLTKQEKRP LPLAPDFDRW LDESDAEMEL 120

RAKEEERLNK LRLESEGSPE TLTNLRKGYL FMYNLVQFLG FSWIFVNLTV RFCILGKESP 180 YDTFHTVADM MYFCQMLAW ETINAAIGVT TSPVLPSLIQ LLGRNFILFI IFGTMEEMQN 240

KAWFFVFYL WSAIEIFRYS FYMLTCIDMD WKVLTWLRYT LWIPLYPLGC LAEAVSVIQS 300

IPIFNETGRF SFTLPYPVKI KVRFSPFLQI YLIMIFLGLY INFRHLYKQR RLKMRAGAVA 360 HACDPSALGG

Seq ID NO: 374 DNA sequence Nucleic Acid Accession ft: NM_016 95 Coding sequence: 1-1113

1 11 21 31 41 51

I I I I I I

ATGGAGAATC AGGTGTTGAC GCCGCATGTC TACTGGGCTC AGCGACACCG CGAGCTATAT 60

CTGCGCGTGG AGCTGAGTGA CGTACAGAAC CCTGCCATCA GCATCACTGA AAACGTGCTG 120 CATTTCAAAG CTCAAGGACA TGGTGCCAAA GGAGACAATG TCTATGAATT TCACCTGGAG 180

TTCTTAGACC TTGTGAAACC AGAGCCTGTT TACAAACTGA CCCAGAGGCA GGTAAACATT 240

ACAGTACAGA AGAAAGTGAG TCAGTGGTGG GAGAGACTCA CAAAGCAGGA AAAGCGACCA 300

CTGTTTTTGG CTCCTGACTT TGATCGTTGG CTGGATGAAT CTGATGCGGA AATGGAGCTC 360

AGAGCTAAGG AAGAAGAGCG CCTAAATAAA CTCCGACTGG AAAGCGAAGG CTCTCCTGAA 420 ACTCTTACAA ACTTAAGGAA AGGATACCTG TTTATGTATA ATCTTGTGCA ATTCTTGGGA 480

TTCTCCTGGA TCTTTGTCAA CCTGACTGTG CGATTCTGTA TCTTGGGAAA AGAGTCCTTT 540

TATGACACAT TCCATACTGT GGCTGACATG ATGTATTTCT GCCAGATGCT GGCAGTTGTG 600

GAAACTATCA ATGCAGCAAT TGGAGTCACT ACGTCACCGG TGCTGCCTTC TCTGATCCAG 660

CTTCTTGGAA GAAATTTTAT TTTGTTTATC ATCTTTGGCA CCATGGAAGA AATGCAGAAC 720 AAAGCTGTGG TTTTCTTTGT GTTTTATTTG TGGAGTGCAA TTGAAATTTT CAGGTACTCT 780

TTCTACATGC TGACGTGCAT TGACATGGAT TGGAAGGTGC TCACATGGCT TCGTTACACT 840

CTGTGGATTC CCTTATATCC ACTGGGATGT TTGGCGGAAG CTGTCTCAGT GATTCAGTCC 900

ATTCCAATAT TCAATGAGAC CGGACGATTC AGTTTCACAT TGCCATATCC AGTGAAAATC 960

AAAGTTAGAT TTTCCTTTTT TCTTCAGATT TATCTTATAA TGATATTTTT AGGTTTATAC 1020 ATAAATTTTC GTCACCTTTA TAAACAGCGC AGACTGAAAA TGAGGGCAGG CGCAGTGGCT 1080 CATGCCTGTG ATCCCAGCGC TTTGGGAGGC TGA

Seq ID NO: 375 Protein sequence Protein Accession ft: NP_057479

1 11 21 31 41 51

I I I I I I

MENQVLTPHV YWAQRHRELY LRVELSDVQN PA1SITENVL HFKAQGHGAK GDNVYEEHLE 60 FLDLVKPEPV YKLTQRQVNI TVQKKVSQWW ERLTKQEKRP LFLAPDFDRW LDESDAEMEL 120

RAKEEERLNK LRLESEGSPE TLTNLRKGYL FMYNLVQFLG FSWIFVNLTV RFCILGKESF 180

YDTFHTVADM MYFCQMLAW ETINAAIGVT TSPVLPSLIQ LLGRNFILFI IFGTMEEMQN 240

KAWFFVFYL WSAIEIFRYS FYMLTCIDMD WKVLTWLRYT LWIPLYPLGC LVEAVSVIQS 300

IPIFNETGRF SFTLPYPVKI KVRFSPFLQI YLIMIFLGLY INFRHLYKQR RRRYGKKRKR 360 STKKKDLDGF LPV

Seq ID NO: 376 DNA sequence Nucleic Acid Accession ft: NM_005987 Coding sequence: 1-270

1 11 21 31 41 51

I I I I I I

ATGAATTCTC AGCAGCAGAA GCAGCCTTGC ACCCCACCCC CTCAGCCTCA GCAGCAGCAG 60

GTGAAACAAC CTTGCCAGCC TCCACCCCAG GAACCATGCA TCCCCAAAAC CAAGGAGCCC 120

TGCCAACCCA AGGTGCCTGA GCCCTGCCAC CCCAAAGTGC CTGAGCCCTG CCAGCCCAAG 180

ATTCCAGAGC CCTGCCAGCC CAAGGTGCCT GAGCCCTGCC CTTCAACGGT CACTCCAGCA 240 CCAGCCCAGC AGAAGACCAA GCAGAAGTAA

Seq ID NO: 377 Protein sequence Protein Accession ft: NP 005978

1 11 21 31 41 51

M INSQQQKQPC TIPPPQPQQQQ VIKQPCQPPPQ EIPCIPKTKEP CIQPKVPEPCH PIKVPEPCQPK IPEPCQPKVP EPCPSTVTPA PAQQKTKQK

Seq ID NO: 378 DNA sequence Nucleic Acid Accession ft: NM_002105 Coding sequence: 74-505

1 11 21 31 41 51

I I I I I I

ACAGCAGTTA CACTGCGGCG GGCGTCTGTT CTAGTGTTTG AGCCGTCGTG CTTCACCGGT 60

CTACCTCGCT AGCATGTCGG GCCGCGGCAA GACTGGCGGC AAGGCCCGCG CCAAGGCCAA 120

GTCGCGCTCG TCGCGCGCCG GCCTCCAGTT CCCAGTGGGC CGTGTACACC GGCTGCTGCG 180

GAAGGGCCAC TACGCCGAGC GCGTTGGCGC CGGCGCGCCA GTGTACCTGG CGGCAGTGCT 240

GGAGTACCTC ACCGCTGAGA TCCTGGAGCT GGCGGGCAAT GCGGCCCGCG ACAACAAGAA 300

GACGCGAATC ATCCCCCGCC ACCTGCAGCT GGCCATCCGC AACGACGAGG AGCTCAACAA 360 GCTGCTGGGC GGCGTGACGA TCGCCCAGGG AGGCGTCCTG CCCAACATCC AGGCCGTGCT 420

GCTGCCCAAG AAGACCAGCG CCACCGTGGG GCCGAAGGCG CCCTCGGGCG GCAAGAAGGC 480

CACCCAGGCC TCCCAGGAGT ACTAAGAGGG CCCGCGCCGC GGCCGGCCGC CCCAGCTCCC 540

CATGCCACCA CAAAGGCCCT TTTAAGGGCC ACCACCGCCC TCATGGAAAG AGCTGAGCCG 600

CTTCAGACTG CGGGGCAAGC GGGCCGCGGC TCCCTTCCCC TCCCCTCCCC TCGCCCGCCT 660 TCGCCGCCCG GCCTCGAGTC CCCGCCCGCC CCCGCTCCCG TCCCGCACCG CCTGCCGCGT 720

CGGCCTCGGG CCTGCCCTGT CCGCCGTCCG CCCTCCGGTA GGGTTCGGGC CTTCCGGATG 780

CGGCTTGGGC GCTCTTCGGG GACCTCCGTG GCGCGGAAGA CCCGAGCCTG CCGGGGGGAG 840 GCCGGCGGCG CCGCACCTGC CCGCCTCGGC GTTCGTGACT CAGCCGCCCC ATCCCGAGTC 900

GCTAAGGGGC TGCGGGGAGG CCGCAGCACC TTCTGGAAGA CTTGGCCTTC CGCTCTGACG 960

CAGGGCCGAG GTGGGCAGTC CAGGCCGAGA GCCGGCGGCC CTGAAGGTGA GTGAGGCCCT 1020

CGGCAGCTGC AGCCGGGGTG TCTGGTACCC CCCCGGCGTG GTGCTTAGCC CAGGACTTTC 1080

AGACGGCCGC TGGCCGGGAG GCTTTGGTGG GAGAGACGCG ATCGCCGATT TCGGTCTGGC 1140

GCCCCTTCTG CGGCCGGGAC CCAGGCCTTT CACATCAGCT CTCCCTCCAT CTTCATTCAT 1200

AGGTCTGCGC TGGGGCCGGG ACGAAGCACT TGGTAACAGG CACATCTTCC TCCCGAGTGA 1260

CTGCCTCCTA GGAGGACATT TAGGGGAGGG CAGAGGCCTG CAGTTTGGCT TCACGGCTGG 1320

CTATGTGGAC AGCAAGAGTC GTTTTGCGGA ACGCGACTGG CAGCCAGGCC TGTCGGGCCC 1380

CCGACGCCGC CCCATTTCCC TTCCAGCAAA CTCAACTCGG CAATCCAAGC ACCTAGATAC 1440

CAGCACAAGT CGGTTAATCC CTGTCTGGAC TGAGCCTCCG TTGGCTTCTG AACTGGAATT 1500

CTGCAGCTAA CCCTTCCACG ACTAGAACCT TAGGCATTGG GGAGTTTTAG ATGGACTAAT 1560 TTTATTAAAG GATTGTTTTT TTTTT

Seq ID NO: 379 Protein sequence Protein Accession ft: NP_002096

1 11 21 31 41 51

I I I I I I

MSGRGKTGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGHY AERVGAGAPV YLAAVLEYLT 60 AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGG VTIAQGGVLP NIQAVLLPKK 120 TSATVGPKAP SGGKKATQAS QEY

Seq ID NO: 380 DNA sequence Nucleic Acid Accession ft: AL136942 Coding sequence: 184-864 1 11 21 31 41 51 i i i i i i

ACGCGTCCGG CAGAAGCTCG GAGCTCTCGG GGTATCGAGG AGGCAGGCCC GCGGGCGCAC 60

GGGCGAGCGG GCCGGGAGCC GGAGCGGCGG AGGAGCCGGC AGCAGCGGCG CGGCGGGCTC 120

CAGGCGAGGC GGTCGACGCT CCTGAAAACT TGCGCGCGCG CTCGCGCCAC TGCGCCCGGA 180

GCGATGAAGA TGGTCGCGCC CTGGACGCGG TTCTACTCCA ACAGCTGCTG CTTGTGCTGC 240

CATGTCCGCA CCGGCACCAT CCTGCTCGGC GTCTGGTATC TGATCATCAA TGCTGTGGTA 300

CTGTTGATTT TATTGAGTGC CCTGGCTGAT CCGGATCAGT ATAACTTTTC AAGTTCTGAA 360

CTGGGAGGTβ ACTTTGAGTT CATGGATGAT GCCAACATGT GCATTGCCAT TGCGATTTCT 420

CTTCTCATGA TCCTGATATG TGCTATGGCT ACTTACGGAG CGTACAAGCA ACGGGCAGCC 480

TGGATCATCC CATTCTTCTG TTACCAGATC TTTGACTTTG CCCTGAACAT GTTGGTTGCA 540

ATCACTGTGC TTATTTATCC AAACTCCATT CAGGAATACA TACGGCAACT GCCTCCTAAT 600

TTTCCCTACA GAGATGATGT CATGTCAGTG AATCCTACCT GTTTGGTCCT TATTATTCTT 660

CTGTTTATTA GCATTATCTT GACTTTTAAG GGTTACTTGA TTAGCTGTGT TTGGAACTGC 720

TACCGATACA TCAATGGTAG GAACTCCTCT GATGTCCTGG TTTATGTTAC CAGCAATGAC 780

ACTACGGTGC TGCTACCCCC GTATGATGAT GCCACTGTGA ATGGTGCTGC CAAGGAGCCA 840

CCGCCACCTT ACGTGTCTGC CTAAGCCTTC AAGTGGGCGG AGCTGAGGGC AGCAGCTTGA 900

CTTTGCAGAC ATCTGAGCAA TAGTTCTGTT ATTTCACTTT TGCCATGAGC CTCTCTGAGC 960

TTGTTTGTTG CTGAAATGCT ACTTTTTAAA ATTTAGATGT TAGATTGAAA ACTGTAGTTT 1020

TCAACATATG CTTTGCTAGA ACACTGTGAT AGATTAACTG TAGAATTCTT CCTGTACGAT 1080

TGGGGATATA ACGGGCTTCA CTAACCTTCC CTAGGCATTG AAACTTCCCC CAAATCTGAT 1140

GGACCTAGAA GTCTGCTTTT GTACCTGCTG GGCCCCAAAG TTGGGCATTT TTCTCTCTGT 1200

TCCCTCTCTT TTGAAAATGT AAAATAAAAC CAAAAATAGA CAACTTTTTC TTCAGCCATT 1260

CCAGCATAGA GAACAAAACC TTATGGAAAC AGGAATGTCA ATTGTGTAAT CATTGTTCTA 1320

ATTAGGTAAA TAGAAGTCCT TATGTATGTG TTACAAGAAT TTCCCCCACA ACATCCTTTA 1380

TGACTGAAGT TCAATGACAG TTTGTGTTTG GTGGTAAAGG ATTTTCTCCA TGGCCTGAAT 1440

TAAGACCATT AGAAAGCACC AGGCCGTGGG AGCAGTGACC ATCTACTGAC TGTTCTTGTG 1500

GATCTTGTGT CCAGGGACAT GGGGTGACAT GCCTCGTATG TGTTAGAGGG TGGAATGGAT 1560

GTGTTTGGCG CTGCATGGGA TCTGGTGCCC CTCTTCTCCT GGATTCACAT CCCCACCCAG 1620

GGCCCGCTTT TACTAAGTGT TCTGCCCTAG ATTGGTTCAA GGAGGTCATC CAACTGACTT 1680

TATCAAGTGG AATTGGGATA TATTTGATAT ACTTCTGCCT AACAACATGG AAAAGGGTTT 1740

TCTTTTCCCT GCAAGCTACA TCCTACTGCT TTGAACTTCC AAGTATGTCT AGTCACCTTT 1800

TAAAATGTAA ACATTTTCAG AAAAATGAGG ATTGCCTTCC TTGTATGCGC TTTTTACCTT 1860

GACTACCTGA ATTGCAAGGG ATTTTTATAT ATTCATATGT TACAAAGTCA GCAACTCTCC 1920

TGTTGGTTCA TTATTGAATG TGCTGTAAAT TAAGTCGTTT GCAATTAAAA CAAGGTTTGC 1980 CCACATCCAA AAAAAAAAAA AAAAA

Seq ID NO: 381 Protein sequence Protein Accession ft: CAB66876

1 11 21 31 41 51

I I I I I I

MKMVAPWTRF YSNSCCLCCH VRTGTILLGV WYLIINAWL LILLSALADP DQYNFSSSEL 60

GGDFEFMDDA NMCIAIAISL LMILICAMAT YGAYKQRAAW IIPFFCYQIF DFALNMLVAI 120

TVLIYPNSIQ EYIRQLPPNF PYRDDVMSVN PTCLVLIILL FISIILTFKG YLISCVWNCY 180

RYINGRNSSD VLVYVTSNDT TVLLPPYDDA TVNGAAKEPP PPYVSA

Seq ID NO: 382 DNA sequence Nucleic Acid Accession ft: NM_002510 Coding sequence: 92-1774

1 11 21 31 41 51

I I I I I I

CAGATGCCAG AAGAACACTG TTGCTCTTGG TGGACGGGCC CAGAGGAATT CAGAGTTAAA 60

CCTTGAGTGC CTGCGTCCGT GAGAATTCAG CATGGAATGT CTCTACTATT TCCTGGGATT 120 TCTGCTCCTG GCTGCAAGAT TGCCACTTGA TGCCGCCAAA CGATTTCATG ATGTGCTGGG 180

CAATGAAAGA CCTTCTGCTT ACATGAGGGA GCACAATCAA TTAAATGGCT GGTCTTCTGA 240

TGAAAATGAC TGGAATGAAA AACTCTACCC AGTGTGGAAG CGGGGAGACA TGAGGTGGAA 300

AAACTCCTGG AAGGGAGGCC GTGTGCAGGC GGTCCTGACC AGTGACTCAC CAGCCCTCGT 360 GGGCTCAAAT ATAACATTTG CGGTGAACCT GATATTCCCT AGATGCCAAA AGGAAGATGC 420

CAATGGGAAC ATAGTCTATG AGAAGAACTG CAGAAATGAG GCTGGTTTAT CTGCTGATCC 480

ATATGTTTAC AACTGGACAG CATGGTCAGA GGACAGTGAC GGGGAAAATG GCACCGGCCA 540

AAGCCATCAT AACGTCTTCC CTGATGGGAA ACCTTTTCCT CACCACCCCG GATGGAGAAG 600

ATGGAATTTC ATCTACGTCT TCCACACACT TGGTCAGTAT TTCCAGAAAT TGGGACGATG 660

TTCAGTGAGA GTTTCTGTGA ACACAGCCAA TGTGACACTT GGGCCTCAAC TCATGGAAGT 720

GACTGTCTAC AGAAGACATG GACGGGCATA TGTTCCCATC GCACAAGTGA AAGATGTGTA 780

CGTGGTAACA GATCAGATTC CTGTGTTTGT GACTATGTTC CAGAAGAACG ATCGAAATTC 840

ATCCGACGAA ACCTTCCTCA AAGATCTCCC CATTATGTTT GATGTCCTGA TTCATGATCC 900

TAGCCACTTC CTCAATTATT CTACCATTAA CTACAAGTGG AGCTTCGGGG ATAATACTGG 960

CCTGTTTGTT TCCACCAATC ATACTGTGAA TCACACGTAT GTGCTCAATG GAACCTTCAG 1020

CCTTAACCTC ACTGTGAAAG CTGCAGCACC AGGACCTTGT CCGCCACCGC CACCACCACC 1080

CAGACCTTCA AAACCCACCC CTTCTTTAGG ACCTGCTGGT GACAACCCCC TGGAGCTGAG 1140

TAGGATTCCT GATGAAAACT GCCAGATTAA CAGATATGGC CACTTTCAAG CCACCATCAC 1200

AATTGTAGAG GGAATCTTAG AGGTTAACAT CATCCAGATG ACAGACGTCC TGATGCCGGT 1260

GCCATGGCCT GAAAGCTCCC TAATAGACTT TGTCGTGACC TGCCAAGGGA GCATTCCCAC 1320

GGAGGTCTGT ACCATCATTT CTGACCCCAC CTGCGAGATC ACCCAGAACA CAGTCTGCAG 1380

CCCTGTGGAT GTGGATGAGA TGTGTCTGCT GACTGTGAGA CGAACCTTCA ATGGGTCTGG 1440

GACGTACTGT GTGAACCTCA CCCTGGGGGA TGACACAAGC CTGGCTCTCA CGAGCACCCT 1500

GATTTCTGTT CCTGACAGAG ACCCAGCCTC GCCTTTAAGG ATGGCAAACA GTGCCCTGAT 1560

CTCCGTTGGC TGCTTGGCCA TATTTGTCAC TGTGATCTCC CTCTTGGTGT ACAAAAAACA 1620

CAAGGAATAC AACCCAATAG AAAATAGTCC TGGGAATGTG GTCAGAAGCA AAGGCCTGAG 1680

TGTCTTTCTC AACCGTGCAA AAGCCGTGTT CTTCCCGGGA AACCAGGAAA AGGATCCGCT 1740

ACTCAAAAAC CAAGAATTTA AAGGAGTTTC TTAAATTTCG ACCTTGTTTC TGAAGCTCAC 1800

TTTTCAGTGC CATTGATGTG AGATGTGCTG GAGTGGCTAT TAACCTTTTT TTCCTAAAGA 1860

TTATTGTTAA ATAGATATTG TGGTTTGGGG AAGTTGAATT TTTTATAGGT TAAATGTCAT 1920

TTTAGAGATG GGGAGAGGGA TTATACTGCA GGCAGCTTCA GCCATGTTGT GAAACTGATA 1980

AAAGCAACTT AGCAAGGCTT CTTTTCATTA TTTTTTATGT TTCACTTATA AAGTCTTAGG 2040

TAACTAGTAG GATAGAAACA CTGTGTCCCG AGAGTAAGGA GAGAAGCTAC TATTGATTAG 2100

AGCCTAACCC AGGTTAACTG CAAGAAGAGG CGGGATACTT TCAGCTTTCC ATGTAACTGT 2160

ATGCATAAAG CCAATGTAGT CCAGTTTCTA AGATCATGTT CCAAGCTAAC TGAATCCCAC 2220

TTCAATACAC ACTCATGAAC TCCTGATGGA ACAATAACAG GCCCAAGCCT GTGGTATGAT 2280

GTGCACACTT GCTAGACTCA GAAAAAATAC TACTCTCATA AATGGGTGGG AGTATTTTGG 2340

TGACAACCTA CTTTGCTTGG CTGAGTGAAG GAATGATATT CATATATTCA TTTATTCCAT 2400

GGACATTTAG TTAGTGCTTT TTATATACCA GGCATGATGC TGAGTGACAC TCTTGTGTAT 2460

ATTTCCAAAT TTTTGTATAG TCGCTGCACA TATTTGAAAT CATATATTAA GACTTTCCAA 2520

AGATGAGGTC CCTGGTTTTT CATGGCAACT TGATCAGTAA GGATTTCACC TCTGTTTGTA 2580

ACTAAAACCA TCTACTATAT GTTAGACATG ACATTCTTTT TCTCTCCTTC CTGAAAAATA 2640 AAGTGTGGGA AGAGACAAAA AAAAAAAAA

Seq ID NO: 383 Protein sequence Protein Accession ft: NP 002501 1 11 21 31 41 51 i i i i i i

MECLYYFLGF LLLAARLPLD AAKRFHDVLG NERPSAYMRE HNQLNGWSSD ENDWNEKLYP 60

VWKRGDMRWK NSWKGGRVQA VLTSDSPALV GSNITFAVNL IPPRCQKEDA NGNIVYEKNC 120

RNEAGLSADP YVYNWTAWSE DSDGENGTGQ SHHNVFPDGK PFPHHPGWRR WNFIYVFHTL 180

GQYFQKLGRC SVRVSVNTAN VTLGPQLMEV TVYRRHGRAY VPIAQVKDVY WTDQIPVFV 240

TMFQKNDRNS SDETFLKDLP IMFDVLIHDP SHFLNYSTIN YKWSFGDNTG LFVSTNHTVN 300

HTYVLNGTFS LNLTVKAAAP GPCPPPPPPP RPSKPTPSLG PAGDNPLELS RIPDENCQIN 360

RYGHFQATIT IVEGILEVNI IQMTDVLMPV PWPESSLIDF WTCQGSIPT EVCTIISDPT 420

CEITQNTVCS PVDVDEMCLL TVRRTFNGSG TYCVNLTLGD DTSLALTSTL ISVPDRDPAS 480

PLRMANSALI SVGCLAIFVT VISLLVYKKH KEYNPIENSP GNWRSKGLS VFLNRAKAVF 540 FPGNQEKDPL LKNQEFKGVS

Seq ID NO: 384 DNA sequence Nucleic Acid Accession ft: NM_001134 Coding sequence: 48-1877

1 11 21 31 41 51

T ICCATATTGT GICTTCCACCA CITGCCAATAA CIAAAATAACT AIGCAACCATG AIAGTGGGTGG 60

AATCAATTTT TTTAATTTTC CTACTAAATT TTACTGAATC CAGAACACTG CATAGAAATG 120

AATATGGAAT AGCTTCCATA TTGGATTCTT ACCAATGTAC TGCAGAGATA AGTTTAGCTG 180

ACCTGGCTAC CATATTTTTT GCCCAGTTTG TTCAAGAAGC CACTTACAAG GAAGTAAGCA 240

AAATGGTGAA AGATGCATTG ACTGCAATTG AGAAACCCAC TGGAGATGAA CAGTCTTCAG 300

GGTGTTTAGA AAACCAGCTA CCTGCCTTTC TGGAAGAACT TTGCCATGAG AAAGAAATTT 360

TGGAGAAGTA CGGACATTCA GACTGCTGCA GCCAAAGTGA AGAGGGAAGA CATAACTGTT 420

TTCTTGCACA CAAAAAGCCC ACTCCAGCAT CGATCCCACT TTTCCAAGTT CCAGAACCTG 480

TCACAAGCTG TGAAGCATAT GAAGAAGACA GGGAGACATT CATGAACAAA TTCATTTATG 540

AGATAGCAAG AAGGCATCCC TTCCTGTATG CACCTACAAT TCTTCTTTGG GCTGCTCGCT 600

ATGACAAAAT AATTCCATCT TGCTGCAAAG CTGAAAATGC AGTTGAATGC TTCCAAACAA 660

AGGCAGCAAC AGTTACAAAA GAATTAAGAG AAAGCAGCTT GTTAAATCAA CATGCATGTG 720

CAGTAATGAA AAATTTTGGG ACCCGAACTT TCCAAGCCAT AACTGTTACT AAACTGAGTC 780

AGAAGTTTAC CAAAGTTAAT TTTACTGAAA TCCAGAAACT AGTCCTGGAT GTGGCCCATG 840

TACATGAGCA CTGTTGCAGA GGAGATGTGC TGGATTGTCT GCAGGATGGG GAAAAAATCA 900

TGTCCTACAT ATGTTCTCAA CAAGACACTC TGTCAAACAA AATAACAGAA TGCTGCAAAC 960

TGACCACGCT GGAACGTGGT CAATGTATAA TTCATGCAGA AAATGATGAA AAACCTGAAG 1020

GTCTATCTCC AAATCTAAAC AGGTTTTTAG GAGATAGAGA TTTTAACCAA TTTTCTTCAG 1080

GGGAAAAAAA TATCTTCTTG GCAAGTTTTG TTCATGAATA TTCAAGAAGA CATCCTCAGC 1140

TTGCTGTCTC AGTAATTCTA AGAGTTGCTA AAGGATACCA GGAGTTATTG GAGAAGTGTT 1200

TCCAGACTGA AAACCCTCTT GAATGCCAAG ATAAAGGAGA AGAAGAATTA CAGAAATACA 1260

TCCAGGAGAG CCAAGCATTG GCAAAGCGAA GCTGCGGCCT CTTCCAGAAA CTAGGAGAAT 1320

ATTACTTACA AAATGCGTTT CTCGTTGCTT ACACAAAGAA AGCCCCCCAG CTGACCTCGT 1380

CGGAGCTGAT GGCCATCACC AGAAAAATGG CAGCCACAGC AGCCACTTGT TGCCAACTCA 1440

GTGAGGACAA ACTATTGGCC TGTGGCGAGG GAGCGGCTGA CATTATTATC GGACACTTAT 1500 GTATCAGACA TGAAATGACT CCAGTAAACC CTGGTGTTGG CCAGTGCTGC ACTTCTTCAT 1560

ATGCCAACAG GAGGCCATGC TTCAGCAGCT TGGTGGTGGA TGAAACATAT GTCCCTCCTG 1620

CATTCTCTGA TGACAAGTTC ATTTTCCATA AGGATCTGTG CCAAGCTCAG GGTGTAGCGC 1680

TGCAAACGAT GAAGCAAGAG TTTCTCATTA ACCTTGTGAA GCAAAAGCCA CAAATAACAG 1740

AGGAACAACT TGAGGCTGTC ATTGCAGATT TCTCAGGCCT GTTGGAGAAA TGCTGCCAAG 1800

GCCAGGAACA GGAAGTCTGC TTTGCTGAAG AGGGACAAAA ACTGATTTCA AAAACTCGTG 1860

CTGCTTTGGG AGTTTAAATT ACTTCAGGGG AAGAGAAGAC AAAACGAGTC TTTCATTCGG 1920

TGTGAACTTT TCTCTTTAAT TTTAACTGAT TTAACACTTT TTGTGAATTA ATGAAATGAT 1980 AAAGACTTTT ATGTGAGATT TCCTTATCAC AGAAATAAAA TATCTCCAAA TG

Seq ID NO: 385 Protein sequence Protein Accession ft: NP_001125

1 11 21 31 41 51

I I I I I I

MKWVESIFLI FLLNFTESRT LHRNEYGIAS ILDSYQCTAE ISLADLATIF FAQFVQEATY 60

KEVSKMVKDA LTAIEKPTGD' EQSSGCLENQ LPAFLEELCH EKEILEKYGH SDCCSQSEEG 120

RHNCFLAHKK PTPASIPLFQ VPEPVTSCEA YEEDRETFMN KFIYEIARRH PPLYAPTILL 180

KAARYDKIIP SCCKAENAVE CFQTKAATVT KELRESSLLN QHACAVMKNF GTRTFQAITV 240

TKLSQKFTKV NFTEIQKLVL DVAHVHEHCC RGDVLDCLQD GEKIMSYICS QQDTLSNKIT 300

ECCKLTTLER GQCIIHAEND EKPEGLSPNL NRFLGDRDFN QFSSGEKNIF LASFVHEYSR 360

RHPQLAVSVI LRVAKGYQEL LEKCFQTENP LECQDKGEEE LQKYIQESQA LAKRSCGLFQ 420

KLGEYYLQNA FLVAYTKKAP QLTSSELMAI TRKMAATAAT CCQLSEDKLL ACGEGAADII 480

IGHLCIRHEM TPVNPGVGQC CTSSYANRRP CFSSLWDET YVPPAFSDDK FIFHKDLCQA 540

QGVALQTMKQ EPLINLVKQK PQITEEQLEA VIADFSGLLE KCCQGQEQEV CPAEEGQKLI 600 SKTRAALGV

Seq ID NO: 386 DNA sequence Nucleic Acid Accession ft: NM_002205.1 Coding sequence: 1..3149

1 11 21 31 41 51

I I . I ^• I I I

ATGGGGAGCC GGACGCCAGA GTCCCCTCTC CACGCCGTGC AGCTGGGCTG GGGCCCCCGG 60

CGCCGACCCC CGCTSSTGCC GCTGCTGTTG CTGCTSSTGC CGCCGCCACC CAGGGTCGGG 120

GGCTTCAACT TAGACGCGGA GGCCCCAGCA GTACTCTCGG GGCCCCCGGG CTCCTTCTTC 180

GGATTCTCAG TGGAGTTTTA CCGGCCGGGA ACAGACGGGG TCAGTGTGCT GGTGGGAGCA 240

CCCAAGGCTA ATACCAGCCA GCCAGGAGTG CTGCAGGGTG GTGCTGTCTA CCTCTGTCCT 300

TGGGGTGCCA GCCCCACACA GTGCACCCCC ATTGAATTTG ACAGCAAAGG CTCTCGGCTC 360

CTGGAGTCCT CACTGTCCAG CTCAGAGGGA GAGGAGCCTG TGGAGTACAA GTCCTTGCAG 420

TGGTTCGGGG CAACAGTTCG AGCCCATGGC TCCTCCATCT TGGCATGCGC TCCACTGTAC 480

AGCTGGCGCA CAGAGAAGGA GCCACTGAGC GACCCCCTGG GCACCTGCTA CCTCTCCACA 540

GATAACTTCA CCCGAATTCT GGAGTATGCA CCCTGCCGCT CAGATTTCAG CTGGGCAGCA 600

GGACAGGGTT ACTGCCAAGG AGGCTTCAGT GCCGAGTTCA CCAAGACTGG CCGTGTGGTT 660

TTAGGTGGAC CAGGAAGCTA TTTCTGGCAA GGCCAGATCC TGTCTGCCAC TCAGGAGCAG 720

ATTGCAGAAT CTTATTACCC CGAGTACCTG ATCAACCTGG TTCAGGGGCA GCTGCAGACT 780

CGCCAGGCCA GTTCCATCTA TGATGACAGC TACCTAGGAT ACTCTGTGGC TGTTGGTGAA 840

TTCAGTGGTG ATGACACAGA AGACTTTGTT GCTGGTGTGC CCAAAGGGAA CCTCACTTAC 900

GGCTATGTCA CCATCCTTAA TGGCTCAGAC ATTCGATCCC TCTACAACTT CTCAGGGGAA 960

CAGATGGCCT CCTACTTTGG CTATGCAGTG GCCGCCACAG ACGTCAATGG GGACGGGCTG 1020

GATGACTTGC TGGTGGGGGC ACCCCTGCTC ATGGATCGGA CCCCTGACGG GCGGCCTCAG 1080

GAGGTGGGCA GGGTCTACGT CTACCTGCAG CACCCAGCCG GCATAGAGCC CACGCCCACC 1140

CTTACCCTCA CTGGCCATGA TGAGTTTGGC CGATTTGGCA GCTCCTTGAC CCCCCTGGGG 1200

GACCTGGACC AGGATGGCTA CAATGATGTG GCCATCGGGG CTCCCTTTGG TGGGGAGACC 1260

CAGCAGGGAG TAGTGTTTGT ATTTCCTGGG GGCCCAGGAG GGCTGGGCTC TAAGCCTTCC 1320

CAGGTTCTGC AGCCCCTGTG GGCAGCCAGC CACACCCCAG ACTTCTTTGG CTCTGCCCTT 1380

CGAGGAGGCC GAGACCTGGA TGGCAATGGA TATCCTGATC TGATTGTGGG GTCCTTTGGT 1440

GTGGACAAGG CTGTGGTATA CAGGGGCCGC CCCATCGTGT CCGCTAGTGC CTCCCTCACC 1500

ATCTTCCCCG CCATGTTCAA CCCAGAGGAG CGGAGCTGCA GCTTAGAGGG GAACCCTGTG 1560

GCCTGCATCA ACCTTAGCTT CTGCCTCAAT GCTTCTGGAA AACACGTTGC TGACTCCATT 1620

GGTTTCACAG TGGAACTTCA GCTGGACTGG CAGAAGCAGA AGGGAGGGGT ACGGCGGGCA 1680

CTGTTCCTGG CCTCCAGGCA GGCAACCCTG ACCCAGACCC TGCTCATCCA GAATGGGGCT 1740

CGAGAGGATT GCAGAGAGAT GAAGATCTAC CTCAGGAACG AGTCAGAATT TCGAGACAAA 1800

CTCTCGCCGA TTCACATCGC TCTCAACTTC TCCTTGGACC CCCAAGCCCC AGTGGACAGC 1860

CACGGCCTCA GGCCAGCCCT ACATTATCAG AGCAAGAGCC GGATAGAGGA CAAGGCTCAG 1920

ATCTTGCTGG ACTGTGGAGA AGACAACATC TGTGTGCCTG ACCTGCAGCT GGAAGTGTTT 1980

GGGGAGCAGA ACCATGTGTA CCTGGGTGAC AAGAATGCCC TGAACCTCAC TTTCCATGCC 2040

CAGAATGTGG GTGAGGGTGG CGCCTATGAG GCTGAGCTTC GGGTCACCGC CCCTCCAGAG 2100

GCTGAGTACT CAGGACTCGT CAGACACCCA GGGAACTTCT CCAGCCTGAG CTGTGACTAC 2160

TTTGCCGTGA ACCAGAGCCG CCTGCTGGTG TGTGACCTGG GCAACCCCAT GAAGGCAGGA 2220

GCCAGTCTGT GGGGTGGCCT TCGGTTTACA GTCCCTCATC TCCGGGACAC TAAGAAAACC 2280

ATCCAGTTTG ACTTCCAGAT CCTCAGCAAG AATCTCAACA ACTCGCAAAG CGACGTGGTT 2340

TCCTTTCGGC TCTCCGTGGA GGCTCAGGCC CAGGTCACCC TGAACGGTGT CTCCAAGCCT 2400

GAGGCAGTGC TATTCCCAGT AAGCGACTGG CATCCCCGAG ACCAGCCTCA GAAGGAGGAG 2460

GACCTGGGAC CTGCTGTCCA CCATGTCTAT GAGCTCATCA ACCAAGGCCC CAGCTCCATT 2520

AGCCAGGGTG TGCTGGAACT CAGCTGTCCC CAGGCTCTGG AAGGTCAGCA GCTCCTATAT 2580

GTGACCAGAG TTACGGGACT CAACTGCACC ACCAATCACC CCATTAACCC AAAGGGCCTG 2640

GAGTTGGATC CCGAGGGTTC CCTGCACCAC CAGCAAAAAC GGGAAGCTCC AAGCCGCAGC 2700

TCTGCTTCCT CGGGACCTCA GATCCTGAAA TGCCCGGAGG CTGAGTGTTT CAGGCTGCGC 2760

TGTGAGCTCG GGCCCCTGCA CCAACAAGAG AGCCAAAGTC TGCAGTTGCA TTTCCGAGTC 2820

TGGGCCAAGA CTTTCTTGCA GCGGGAGCAC CAGCCATTTA GCCTGCAGTG TGAGGCTGTG 2880

TACAAAGCCC TGAAGATGCC CTACCGAATC CTGCCTCGGC AGCTGCCCCA AAAAGAGCGT 2940

CAGGTGGCCA CAGCTGTGCA ATGGACCAAG GCAGAAGGCA GCTATGGCGT CCCACTGTGG 3000

ATCATCATCC TAGCCATCCT GTTTGGCCTC CTGCTCCTAG GTCTACTCAT CTACATCCTC 3060

TACAAGCTTG GATTCTTCAA ACGCTCCCTC CCATATGGCA CCGCCATGGA AAAAGCTCAG 3120 CTCAAGCCTC CAGCCACCTC TGATGCCTGA Seq ID NO: 387 Protein sequence Protein Accession ft: NP_002196.1

1 11 21 31 41 51

I I I I I I

MGSRTPESPL HAVQLRWGPR RRPPLLPLLL LLLPPPPRVG GFNLDAEAPA VLSGPPGSFF 60

GFSVEFYRPG TDGVSVLVGA PKANTSQPGV LQGGAVYLCP WGASPTQCTP IEFDSKGSRL 120

LESSLSSSEG EEPVEYKSLQ WFGATVRAHG SSILACAPLY SWRTEKEPLS DPVGTCYLST 180

DNFTRILEYA PCRSDFSWAA GQGYCQGGFS AEFTKTGR LGGPGSYFWQ GQILSATQEQ 240

IAESYYPEYL ^'INLVQGQLQT RQASSIYDDS YLGYSVAVGE FSGDDTEDFV AGVPKGNLTY 300

GYVTILNGSD IRSLYNFSGE QMASYFGYAV AATDVNGDGL DDLLVGAPLL MDRTPDGRPQ 360

EVGRVYVYLQ HPAGIEPTPT LTLTGHDEFG RFGSSLTPLG DLDQDGYNDV AIGAPFGGET 420

QQGWFVFPG GPGGLGSKPS QVLQPLWAAS HTPDFFGSAL RGGRDLDGNG YPDLIVGSFG 480

VDKAWYRGR PIVSASASLT IFPAMFNPEE RSCSLEGNPV ACINLSFCLN ASGKHVADSI 540

GFTVELQLDW QKQKGGVRRA LFLASRQATL TQTLLIQNGA REDCREMKIY LRNESEFRDK 600

LSPIHIALNF SLDPQAPVDS HGLRPALHYQ SKSRIEDKAQ ILLDCGEDNI CVPDLQLEVF 660

GEQNHVYLGD KNALNLTFHA QNVGEGGAYE AELRVTAPPE AEYSGLVRHP GNFSSLSCDY 720

FAVNQSRLLV CDLGNPMKAG ASLWGGLRFT VPHLRDTKKT IQFDFQILSK NLNNSQSDW 780

SFRLSVEAQA QVTLNGVSKP EAVLFPVSDW HPRDQPQKEE DLGPAVHHVY ELINQGPSSI 840

SQGVLELSCP QALEGQQLLY VTRVTGLNCT TNHPINPKGL ELDPEGSLHH QQKREAPSRS 900

SASSGPQILK CPEAECFRLR CELGPLHQQE SQSLQLHFRV WAKTFLQREH QPFSLQCEAV 960

YKALKMPYRI LPRQLPQKER QVATAVQWTK AEGSYGVPLW IIILAILFGL LLLGLLIYIL 1020 YKLGFFKRSL PYGTAMEKAQ LKPPATSDA

Seq' ID NO: 388 DNA sequence

Nucleic Acid Accession ft: NM_002425

Coding sequence: 26..1453

1 11 21 31 41 51

I I I I I I

AAAGAAGGTA AGGGCAGTGA GAATGATGCA TCTTGCATTC CTTGTGCTGT TGTGTCTGCC 60

AGTCTGCTCT GCCTATCCTC TGAGTGGGGC AGCAAAAGAG GAGGACTCCA ACAAGGATCT 120

TGCCCAGCAA TACCTAGAAA AGTACTACAA CCTCGAAAAG GATGTGAAAC AGTTTAGAAG 180

AAAGGACAGT AATCTCATTG TTAAAAAAAT CCAAGGAATG CAGAAGTTCC TTGGGTTGGA 240

GGTGACAGGG AAGCTAGACA CTGACACTCT GGAGGTGATG CGCAAGCCCA GGTGTGGAGT 300

TCCTGACGTT GGTCACTTCA GCTCCTTTCC TGGCATGCCG AAGTGGAGGA AAACCCACCT 360

TACATACAGG ATTGTGAATT ATACACCAGA TTTGCCAAGA GATGCTGTTG ATTCTGCCAT 420

TGAGAAAGCT CTGAAAGTCT GGGAAGAGGT GACTCCACTC ACATTCTCCA GGCTGTATGA 480

AGGAGAGGCT GATATAATGA TCTCTTTCGC AGTTAAAGAA CATGGAGACT TTTACTCTTT 540

TGATGGCCCA GGACACAGTT TGGCTCATGC CTACCCACCT GGACCTGGGC TTTATGGAGA 600

TATTCACTTT GATGATGATG AAAAATGGAC AGAAGATGCA TCAGGCACCA ATTTATTCCT 660

CGTTGCTGCT CATGAACTTG GCCACTCCCT GGGGCTCTTT CACTCAGCCA ACACTGAAGC 720

TTTGATGTAC CCACTCTACA ACTCATTCAC AGAGCTCGCC CAGTTCCGCC TTTCGCAAGA 780

TGATGTGAAT GGCATTCAGT CTCTCTACGG ACCTCCCCCT GCCTCTACTG AGGAACCCCT 840

GGTGCCCACA AAATCTGTTC CTTCGGGATC TGAGATGCCA GCCAAGTGTG ATCCTGCTTT 900

GTCCTTCGAT GCCATCAGCA CTCTGAGGGG AGAATATCTG TTCTTTAAAG ACAGATATTT 960

TTGGCGAAGA TCCCACTGGA ACCCTGAACC TGAATTTCAT TTGATTTCTG CATTTTGGCC 1020

CTCTCTTCCA TCATATTTGG ATGCTGCATA TGAAGTTAAC AGCAGGGACA CCGTTTTTAT 1080

TTTTAAAGGA AATGAGTTCT GGGCCATCAG AGGAAATGAG GTACAAGCAG GTTATCCAAG 1140

AGGCATCCAT ACCCTGGGTT TTCCTCCAAC CATAAGGAAA ATTGATGCAG CTGTTTCTGA 1200

CAAGGAAAAG AAGAAAACAT ACTTCTTTGC AGCGGACAAA TACTGGAGAT TTGATGAAAA 1260

TAGCCAGTCC ATGGAGCAAG GCTTCCCTAG ACTAATAGCT GATGACTTTC CAGGAGTTGA 1320

GCCTAAGGTT GATGCTGTAT TACAGGCATT TGGATTTTTC TACTTCTTCA GTGGATCATC 1380

ACAGTTTGAG TTTGACCCCA ATGCCAGGAT GGTGACACAC ATATTAAAGA GTAACAGCTG 1440

GTTACATTGC TAGGCGAGAT AGGGGGAAGA CAGATATGGG TGTTTTTAAT AAATCTAATA 1500

ATTATTCATC TAATGTATTA TGAGCCAAAA TGGTTAATTT TTCCTGCATG TTCTGTGACT 1560

GAAGAAGATG AGCCTTGCAG ATATCTGCAT GTGTCATGAA GAATGTTTCT GGAATTCTTC 1620

ACTTGCTTTT GAATTGCACT GAACAGAATT AAGAAATACT CATGTGCAAT AGGTGAGAGA 1680

ATGTATTTTC ATAGATGTGT TATTACTTCC TCAATAAAAA GTTTTATTTT GGGCCTGTTC 1740 CTT

Seq ID NO: 389 Protein sequence Protein Accession ft: NP 002416

1 11 21 31 41 51

I I I I I I

MHLAFLVLLC LPVCSAYPLS GAAKEEDSNK DLAQQYLEKY YNLEKDVKQF RRKDSNLIVK 60

KIQGMQKFLG LEVTGKLDTD TLEVMRKPRC GVPDVGHFSS FPGMPKWRKT HLTYRIVNYT 120 PDLPRDAVDS AIEKALKVWE EVTPLTFSRL YEGEADIMIS FAVKEHGDFY SFDGPGHSLA 180

HAYPPGPGLY GDIHFDDDEK WTEDASGTNL FLVAAHELGH SLGLFHSANT EALMYPLYNS 240

FTELAQFRLS QDDVNGIQSL YGPPPASTEE PLVPTKSVPS GSEMPAKCDP ALSFDAISTL 300

RGEYLFFKDR YFWRRSHWNP EPEFHLISAF WPSLPSYLDA AYEVNSRDTV FIFKGNEFWA 360

IRGNEVQAGY PRGIHTLGFP PTIRKIDAAV SDKEKKKTYF FAADKYWRFD ENSQSMEQGF 420 PRLIADDFPG VEPKVDAVLQ AFGFPYFFSG SSQFEFDPNA RMVTHILKSN SWLHC

Seq ID NO: 390 DNA sequence

Nucleic Acid Accession ft: NM_002421.2

Coding sequence: 1..1409

1 11 21 31 41 51

I I I I I I

ATGCACAGCT TTCCTCCACT GCTGCTGCTG CTGTTCTGGG GTGTGGTGTC ACACAGCTTC 60

CCAGCGACTC TAGAAACACA AGAGCAAGAT GTGGACTTAG TCCAGAAATA CCTGGAAAAA 120

TACTACAACC TGAAGAATGA TGGGAGGCAA GTTGAAAAGC GGAGAAATAG TGGCCCAGTG 180

GTTGAAAAAT TGAAGCAAAT GCAGGAATTC TTTGGGCTGA AAGTGACTGG GAAACCAGAT 240

GCTGAAACCC TGAAGGTGAT GAAGCAGCCC AGATGTGGAG TGCCTGATGT GGCTCAGTTT 300 GTCCTCACTG AGGGGAACCC TCGCTGGGAG CAAACACATC TGACCTACAG GATTGAAAAT 360

TACACGCCAG ATTTGCCAAG AGCAGATGTG GACCATGCCA TTGAGAAAGC CTTCCAACTC 420

TGGAGTAATG TCACACCTCT GACATTCACC AAGGTCTCTG AGGGTCAAGC AGACATCATG 480

ATATCTTTTG TCAGGGGAGA TCATCGGGAC AACTCTCCTT TTGATGGACC TGGAGGAAAT 540

CTTGCTCATG CTTTTCAACC AGGCCCAGGT ATTGGAGGGG ATGCTCATTT TGATGAAGAT 600

GAAAGGTGGA CCAACAATTT CAGAGAGTAC AACTTACATC GTGTTGCGGC TCATGAACTC 660

GGCCATTCTC TTGGACTCTC CCATTCTACT GATATCGGGG CTTTGATGTA CCCTAGCTAC 720

ACCTTCAGTG GTGATGTTCA GCTAGCTCAG GATGACATTG ATGGCATCCA AGCCATATAT 780

GGACGTTCCC AAAATCCTGT CCAGGCCATC GGCCCACAAA CCCCAAAAGC ATGTGACAGT 840

AAGCTAACCT TTGATGCTAT AACTACGATT CGGGGAGAAG TGATGTTCTT TAAAGACAGA 900

TTCTACATGC GCACAAATCC CTTCTACCCG GAAGTTGAGC TCAATTTCAT TTCTGTTTTC 960

TGGCCACAAC TGCCAAATGG GCTTGAAGCT GCTTACGAAT TTGCCGACAG AGATGAAGTC 1020

CGGTTTTTCA AAGGGAATAA GTACTGGGCT GTTCAGGGAC AGAATGTGCT ACACGGATAC 1080

CCCAAGGACA TCTACAGCTC CTTTGGCTTC CCTAGAACTG TGAAGCATAT CGATGCTGCT 1140

CTTTCTGAGG AAAACACTGG AAAAACCTAC TTCTTTGTTG CTAACAAATA CTGGAGGTAT 1200

GATGAATATA AACGATCTAT GGATCCAGGT TATCCCAAAA TGATAGCACA TGACTTTCCT 1260

GGAATTGGCC ACAAAGTTGA TGCAGTTTTC ATGAAAGATG GATTTTTCTA TTTCTTTCAT 1320

GGAACAAGAC AATACAAATT TGATGCTAAA ACGAAGAGAA TTTTGACTCT CCAGAAAGCT 1380 AATAGCTGGT TCAACTGCAG GAAAAATTAG

Seq ID NO: 391 Protein sequence Protein Accession ft: NP 002412.1 1 11 21 31 41 51 i i i i i i

MHSFPPLLLL LFWGWSHSF PATLETQEQD VDLVQKYLEK YYNLKNDGRQ VEKRRNSGPV 60

VEKLKQMQEF FGLKVTGKPD AETLKVMKQP RCGVPDVAQF VLTEGNPRWE QTHLTYRIEN 120

YTPDLPRADV DHAIEKAFQL WSNVTPLTFT KVSEGQADIM ISFVRGDHRD NSPFDGPGGN 180

LAHAFQPGPG IGGDAHFDED ERWTNNFREY NLHRVAAHEL GHSLGLSHST DIGALMYPSY 240

TFSGDVQLAQ DDIDGIQAIY GRSQNPVQPI GPQTPKACDS KLTFDAITTI RGEVMFFKDR 300

FYMRTNPFYP EVELNFISVF WPQLPNGLEA AYEFADRDEV RFFKGNKYWA VQGQNVLHGY 360

PKDIYSSFGF PRTVKHIDAA LSEENTGKTY PFVANKYWRY DEYKRSMDPG YPKMIAHDFP 420 GIGHKVDAVF MKDGFFYFFH GTRQYKFDPK TKRILTLQKA NSWFNCRKN

Seq ID NO: 392 DNA sequence

Nucleic Acid Accession ft: NM_002421.2

Coding sequence: 1..1409

11 21 31 41 51

ATGCACAGCT TTCCTCCACT GCTGCTGCTG CTGTTCTGGG GTGTGGTGTC ACACAGCTTC 60

CCAGCGACTC TAGAAACACA AGAGCAAGAT GTGGACTTAG TCCAGAAATA CCTGGAAAAA 120

TACTACAACC TGAAGAATGA TGGGAGGCAA GTTGAAAAGC GGAGAAATAG TGGCCCAGTG 180

GTTGAAAAAT TGAAGCAAAT GCAGGAATTC TTTGGGCTGA AAGTGACTGG GAAACCAGAT 240

GCTGAAACCC TGAAGGTGAT GAAGCAGCCC AGATGTGGAG TGCCTGATGT GGCTCAGTTT 300

GTCCTCACTG AGGGGAACCC TCGCTGGGAG CAAACACATC TGACCTACAG GATTGAAAAT 360

TACACGCCAG ATTTGCCAAG AGCAGATGTG GACCATGCCA TTGAGAAAGC CTTCCAACTC 420

TGGAGTAATG TCACACCTCT GACATTCACC AAGGTCTCTG AGGGTCAAGC AGACATCATG 480

ATATCTTTTG TCAGGGGAGA TCATCGGGAC AACTCTCCTT TTGATGGACC TGGAGGAAAT 540

CTTGCTCATG CTTTTCAACC AGGCCCAGGT ATTGGAGGGG ATGCTCATTT TGATGAAGAT 600

GAAAGGTGGA CCAACAATTT CAGAGAGTAC AACTTACATC GTGTTGCGGC TCATGCCCTC 660

GGCCATTCTC TTGGACTCTC CCATTCTACT GATATCGGGG CTTTGATGTA CCCTAGCTAC 720

ACCTTCAGTG GTGATGTTCA GCTAGCTCAG GATGACATTG ATGGCATCCA AGCCATATAT 780

GGACGTTCCC AAAATCCTGT CCAGGCCATC GGCCCACAAA CCCCAAAAGC ATGTGACAGT 840

AAGCTAACCT TTGATGCTAT AACTACGATT CGGGGAGAAG TGATGTTCTT TAAAGACAGA 900

TTCTACATGC GCACAAATCC CTTCTACCCG GAAGTTGAGC TCAATTTCAT TTCTGTTTTC 960

TGGCCACAAC TGCCAAATGG GCTTGAAGCT GCTTACGAAT TTGCCGACAG AGATGAAGTC 1020

CGGTTTTTCA AAGGGAATAA GTACTGGGCT GTTCAGGGAC AGAATGTGCT ACACGGATAC 1080

CCCAAGGACA TCTACAGCTC CTTTGGCTTC CCTAGAACTG TGAAGCATAT CGATGCTGCT 1140

CTTTCTGAGG AAAACACTGG AAAAACCTAC TTCTTTGTTG CTAACAAATA CTGGAGGTAT 1200

GATGAATATA AACGATCTAT GGATCCAGGT TATCCCAAAA TGATAGCACA TGACTTTCCT 1260

GGAATTGGCC ACAAAGTTGA TGCAGTTTTC ATGAAAGATG GATTTTTCTA TTTCTTTCAT 1320

GGAACAAGAC AATACAAATT TGATCCTAAA ACGAAGAGAA TTTTGACTCT CCAGAAAGCT 1380 AATAGCTGGT TCAACTGCAG GAAAAATTAG

Seq ID NO: 393 Protein sequence Protein Accession ft: NP_002412.1

1 11 21 31 41 51

I I I I I I

MHSFPPLLLL LFWGWSHSF PATLETQEQD VDLVQKYLEK YYNLKNDGRQ VEKRRNSGPV 60

VEKLKQMQEF FGLKVTGKPD AETLKVMKQP RCGVPDVAQF VLTEGNPRWE QTHLTYRIEN 120

YTPDLPRADV DHAIEKAFQL WSNVTPLTFT KVSEGQADIM ISFVRGDHRD NSPFDGPGGN 180

LAHAFQPGPG IGGDAHFDED ERWTNNFREY NLHRVAAHAL GHSLGLSHST DIGALMYPSY 240

TFSGDVQLAQ DDIDGIQAIY GRSQNPVQPI GPQTPKACDS KLTFDAITTI RGEVMFFKDR 300

FYMRTNPFYP EVELNFISVF WPQLPNGLEA AYEFADRDEV RFFKGNKYWA VQGQNVLHGY 360

PKDIYSSFGF PRTVKHIDAA LSEENTGKTY FFVANKYWRY DEYKRSMDPG YPKMIAHDFP 420 GIGHKVDAVF MKDGFFYFFH GTRQYKFDPK TKRILTLQKA NSWFNCRKN

Seq ID NO: 394 DNA sequence

Nucleic Acid Accession ft: NM_014331.2

Coding sequence: 1..1506

1 11 21 31 41 51

I I I I I I ATGGTCAGAA AGCCTGTTGT GTCCACCATC TCCAAAGGAG GTTACCTGCA GGGAAATGTT 60

AACGGGAGGC TGCCTTCCCT GGGCAACAAG GAGCCACCTG GGCAGGAGAA AGTGCAGCTG 120

AAGAGGAAAG TCACTTTACT GAGGGGAGTC TCCATTATCA TTGGCACCAT CATTGGAGCA 180

GGAATCTTCA TCTCTCCTAA GGGCGTGCTC CAGAACACGG GCAGCGTGGG CATGTCTCTG 240

ACCATCTGGA CGGTGTGTGG GGTCCTGTCA CTATTTGGAG CTTTGTCTTA TGCTGAATTG 300

GGAACAACTA TAAAGAAATC TGGAGGTCAT TACACATATA TTTTGGAAGT CTTTGGTCCA 360

TTACCAGCTT TTGTACGAGT CTGGGTGGAA CTCCTCATAA TACGCCCTGC AGCTACTGCT 420

GTGATATCCC TGGCATTTGG ACGCTACATT CTGGAACCAT TTTTTATTCA ATGTGAAATC 480

CCTGAACTTG CGATCAAGCT CATTACAGCT GTGGGCATAA CTGTAGTGAT GGTCCTAAAT 540

AGCATGAGTG TCAGCTGGAG CGCCCGGATC CAGATTTTCT TAACCTTTTG CAAGCTCACA 600

GCAATTCTGA TAATTATAGT CCCTGGAGTT ATGCAGCTAA TTAAAGGTCA AACGCAGAAC 660

TTTAAAGACG CGTTTTCAGG AAGAGATTCA AGTATTACGC GGTTGCCACT GGCTTTTTAT 720

TATGGAATGT ATGCATATGC TGGCTGGTTT TACCTCAACT TTGTTACTGA AGAAGTAGAA 780

AACCCTGAAA AAACCATTCC CCTTGCAATA TGTATATCCA TGGCCATTGT CACCATTGGC 840

TATGTGCTGA CAAATGTGGC CTACTTTACG ACCATTAATG CTGAGGAGCT GCTGCTTTCA 900

AATGCAGTGG CAGTGACCTT TTCTGAGCGG CTACTGGGAA ATTTCTCATT AGCAGTTCCG 960

ATCTTTGTTG CCCTCTCCTG CTTTGGCTCC ATGAACGGTG GTGTGTTTGC TGTCTCCAGG 1020

TTATTCTATG TTGCGTCTCG AGAGGGTCAC CTTCCAGAAA TCCTCTCCAT GATTCATGTC 1080

CGCAAGCACA CTCCTCTACC AGCTGTTATT GTTTTGCACC CTTTGACAAT GATAATGCTC 1140

TTCTCTGGAG ACCTCGACAG TCTTTTGAAT TTCCTCAGTT TTGCCAGGTG GCTTTTTATT 1200

GGGCTGGCAG TTGCTGGGCT GATTTATCTT CGATACAAAT GCCCAGATAT GCATCGTCCT 1260

TTCAAGGTGC CACTGTTCAT CCCAGCTTTG TTTTCCTTCA CATGCCTCTT CATGGTTGCC 1320

CTTTCCCTCT ATTCGGACCC ATTTAGTACA GGGATTGGCT TCGTCATCAC TCTGACTGGA 1380

GTCCCTGCGT ATTATCTCTT TATTATATGG GACAAGAAAC CCAGGTGGTT TAGAATAATG 1440

TCAGAGAAAA TAACCAGAAC ATTACAAATA ATACTGGAAG TTGTACCAGA AGAAGATAAG 1500

TTATGAACTA ATGGACTTGA GATCTTGGCA ATCTGCCCAA GGGGAGACAC AAAATAGGGA 1560

TTTTTACTTC ATTTTCTGAA AGTCTAGAGA ATTACAACTT TGGTGATAAA CAAAAGGAGT 1620

CAGTTATTTT TATTCATATA TTTTAGCATA TTCGAACTAA TTTCTAAGAA ATTTAGTTAT 1680

AACTCTATGT AGTTATAGAA AGTGAATATG CAGTTATTCT ATGAGTCGCA CAATTCTTGA 1740

GTCTCTGATA CCTACCTATT GGGGTTAGGA GAAAAGACTA GACAATTACT ATGTGGTCAT 1800

TCTCTACAAC ATATGTTAGC ACGGCAAAGA ACCTTCAAAT TGAAGACTGA GATTTTTCTG 1860

TATATATGGG TTTTGTAAAG ATGGTTTTAC ACACTACAGA TGTCTATACT GTGAAAAGTG 1920

TTTTCAATTC TGAAAAAAAG CATACATCAT GATTATGGCA AAGAGGAGAG AAAGAAATTT 1980

ATTTTACATT GACATTGCAT TGCTTCCCCT TAGATACCAA TTTAGATAAC AAACACTCAT 2040

GCTTTAATGG ATTATACCCA GAGCACTTTG AACAAAGGTC AGTGGGGATT GTTGAATACA 2100

TTAAAGAAGA GTTTCTAGGG GCTACTGTTT ATGAGACACA TCCAGGAGTT ATGTTTAAGT 2160

AAAAATCCTT GAGAATTTAT TATGTCAGAT GTTTTTTCAT TCATTATCAG GAAGTTTTAG 2220

TTATCTGTCA TTTTTTTTTT TCACATCAGT TTGATCAGGA AAGTGTATAA CACATCTTAG 2280

AGCAAGAGTT AGTTTGGTAT TAAATCCTCA TTAGAACAAC CACCTGTTTC ACTAATAACT 2340

TACCCCTGAT GAGTCTATCT AAACATATGC ATTTTAAGCC TTCAAATTAC ATTATCAACA 2400

TGAGAGAAAT AACCAACAAA GAAGATGTTC AAAATAATAG TCCCATATCT GTAATCATAT 2460

CTACATGCAA TGTTAGTAAT TCTGAAGTTT TTTAAATTTA TGGCTATTTT TACACGATGA 2520

TGAATTTTGA CAGTTTGTGC ATTTTCTTTA TACATTTTAT ATTCTTCTGT TAAAATATCT 2580

CTTCAGATGA AACTGTCCAG ATTAATTAGG AAAAGGCATA TATTAACATA AAAATTGCAA 2640

AAGAAATGTC GCTGTAAATA AGATTTACAA CTGATGTTTC TAGAAAATTT CCACTTCTAT 2700

ATCTAGGCTT TGTCAGTAAT TTCCACACCT TAATTATCAT TCAACTTGCA AAAGAGACAA 2760

CTGATAAGAA GAAAATTGAA ATGAGAATCT GTGGATAAGT GTTTGTGTTC AGAAGATGTT 2820

GTTTTGCCAG TATTAGAAAA TACTGTGAGC CGGGCATGGT GGCTTACATC TGTAATCCCA 2880

GCACTTTGGG AGGCTGAGGG GGTGGATCAC CTGAGGTCGG GAGTTCTAGA CCAGCCTGAC 2940

CAACATGGAG AAACCCCATC TCTACTAAAA ATACAAAATT AGCTGGGCAT GGTGGCACAT 3000

GCTGGTAATC TCAGCTATTG AGGAGGCTGA GGCAGGAGAA TTGCTTGAAC CCGGGAGGCG 3060

GAGGTTGCAG TGAGCCAAGA TTGCACCACT GTACTCCAGC CTGGGTGACA AAGTCAGACT 3120 CCATCTCCAA AAAAAAAAAA AAAA

Seq ID NO: 395 Protein sequence Protein Accession ft: NP_055146.1

1 11 21 31 41 51

M IVRKPWSTI SIKGGYLQGNV NIGRLPSLGNK EIPPGQEKVQL KIRKVTLLRGV SIIIIGTIIGA 60

GIFISPKGVL QNTGSVGMSL TIWTVCGVLS LFGALSYAEL GTTIKKSGGH YTYILEVFGP 120

LPAFVRVWVE LLIIRPAATA VISLAFGRYI LEPFFIQCEI PELAIKLITA VGITWMVLN 180

SMSVSWSARI QIFLTFCKLT AILIIIVPGV MQLIKGQTQN FKDAFSGRDS SITRLPLAFY 240

YGMYAYAGWF YLNFVTEEVE NPEKTIPLAI CISMAITIGV YVLTNVAYFT TINAEELLLS 300

NAVAVTFSER LLGNFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH LPEILSMIHV 360

RKHTPLPAVI VLHPLTMIML FSGDLDSLLN FLSFARWLFI GLAVAGLIYL RYKCPDMHRP 420

FKVPLFIPAL FSFTCLFMVA LSLYSDPFST GIGFVITLTG VPAYYLFIIW DKKPRWFRIM 480 SEKITRTLQI ILEWPEEDK L

Seq ID NO: 396 DNA sequence Nucleic Acid Accession ft: NM_006528 Coding sequence: 57..764

1 11 21 31 41 51

G ICCGCCAGCG G ICTTTCTCGG A ICGCCTTGCC C IAGCGGGCCG C ICCGACCCCC T IGCACCATGG 60

ACCCCGCTCG CCCCCTGGGG CTGTCGATTC TGCTGCTTTT CCTGACGGAG GCTGCACTGG 120

GCGATGCTGC TCAGGAGCCA ACAGGAAATA ACGCGGAGAT CTGTCTCCTG CCCCTAGACT 180

ACGGACCCTG CCGGGCCCTA CTTCTCCGTT ACTACTACGA CAGGTACACG CAGAGCTGCC 240

GCCAGTTCCT GTACGGGGGC TGCGAGGGCA ACGCCAACAA TTTCTACACC TGGGAGGCTT 300

GCGACGATGC TTGCTGGAGG ATAGAAAAAG TTCCCAAAGT TTGCCGGCTG CAAGTGAGTG 360

TGGACGACCA GTGTGAGGGG TCCACAGAAA AGTATTTCTT TAATCTAAGT TCCATGACAT 420

GTGAAAAATT CTTTTCCGGT GGGTGTCACC GGAACCGGAT TGAGAACAGG TTTCCAGATG 480

AAGCTACTTG TATGGGCTTC TGCGCACCAA AGAAAATTCC ATCATTTTGC TACAGTCCAA 540

AAGATGAGGG ACTGTGCTCT GCCAATGTGA CTCGCTATTA TTTTAATCCA AGATACAGAA 600

CCTGTGATGC TTTCACCTAT ACTGGCTGTG GAGGGAATGA CAATAACTTT GTTAGCAGGG 660 AGGATTGCAA ACGTGCATGT GCAAAAGCTT TGAAAAAGAA AAAGAAGATG CCAAAGCTTC 720

GCTTTGCCAG TAGAATCCGG AAAATTCGGA AGAAGCAATT TTAAACATTC TTAATATGTC 780

ATCTTGTTTG TCTTTATGGC TTATTTGCCT TTATGGTTGT ATCTGAAGAA TAATATGACA 840

GCATGAGGAA ACAAATCATT GGTGATTTAT TCACCAGTTT TTATTAATAC AAGTCACTTT 900

TTCAAAAATT TGGATTTTTT TATATATAAC TAGCTGCTAT TCAAATGTGA GTCTACCATT 960

TTTAATTTAT GGTTCAACTG TTTGTGAGAC GAATTCTTGC AATGCATAAG ATATAAAAGC 1020

AAATATGACT CACTCATTTC TTGGGGTCGT ATTCCTGATT TCAGAAGAGG ATCATAACTG 1080

AAACAACATA AGACAATATA ATCATGTGCT TTTAACATAT TTGAGAATAA AAAGGACTAG 1140 CC

Seq ID NO 397 Protein sequence Prote Accession ft: NP 006519

1 11 21 31 41 51 i i i i i i

MDPARPLGLS ILLLFLTEAA LGDAAQEPTG NNAEICLLPL DYGPCRALLL RYYYDRYTQS 60

CRQFLYGGCE GNANNFYTWE ACDDACWRIE KVPKVCRLQV SVDDQCEGST EKYFFNLSSM 120

TCEKPFSGGC HRNRIENRFP DEATCMGFCA PKKIPSFCYS PKDEGLCSAN VTRYYFNPRY 180

RTCDAFTYTG CGGNDNNFVS REDCKRACAK ALKKKKKMPK LRFASRIRKI RKKQF

Seq ID NO: 398 DNA sequence

Nucleic Acid Accession ft: NM_001508.1

Coding sequence: 1..1361

1 11 21 31 41 51

I I I I I I

ATGGCTTCAC CCAGCCTCCC GGGCAGTGAC TGCTCCCAAA TCATTGATCA CAGTCATGTC 60

CCCGAGTTTG AGGTGGCCAC CTGGATCAAA ATCACCCTTA TTCTGGTGTA CCTGATCATC 120

TTCGTGATGG GCCTTCTGGG GAACAGCGTC ACCATTCGGG TCACCCAGGT GCTGCAGAAG 180

AAAGGATACT TGCAGAAGGA GGTGACAGAC CACATGGTGA GTTTGGCTTG CTCGGACATC 240

TTGGTGTTCC TCATCGGCAT GCCCATGGAG TTCTACAGCA TCATCTGGAA TCCCCTGACC 300

ACGTCCAGCT ACACCCTGTC CTGCAAGCTG CACACTTTCC TCTTCGAGGC CTGCAGCTAC 360

GCTACGCTGC TGCACGTGCT GACGCTGAGC TTTGAGCGCT ACATCGCCAT CTGTCACCCC 420

TTCAGGTACA AGGCTGTGTC GGGACCTTGC CAGGTGAAGC TGCTGATTGG CTTCGTCTGG 480

GTCACCTCCG CCCTGGTGGC ACTGCCCTTG CTGTTTGCCA TGGGTACTGA GTACCCCCTG 540

GTGAACGTGC CCAGCCACCG GGGTCTCACT TGCAACCGCT CCAGCACCCG CCACCACGAG 600

CAGCCCGAGA CCTCCAATAT GTCCATCTGT ACCAACCTCT CCAGCCGCTG GACCGTGTTC 660

CAGTCCAGCA TCTTCGGCGC CTTCGTGGTC TACCTCGTGG TCCTGCTCTC CGTAGCCTTC 720

ATGTGCTGGA ACATGATGCA GGTGCTCATG AAAAGCCAGA AGGGCTCGCT GGCCGGGGGC 780

ACGCGGCCTC CGCAGCTGAG GAAGTCCGAG AGCGAAGAGA GCAGGACCGC CAGGAGGCAG 840

ACCATCATCT TCCTGAGGCT GATTGTTGTG ACATTGGCCG TATGCTGGAT GCCCAACCAG 900

ATTCGGAGGA TCATGGCTGC GGCCAAACCC AAGCACGACT GGACGAGGTC CTACTTCCGG 960

GCGTACATGA TCCTCCTCCC CTTCTCGGAG ACGTTTTTCT ACCTCAGCTC GGTCATCAAC 1020

CCGCTCCTGT ACACGGTGTC CTCGCAGCAG TTTCGGCGGG TGTTCGTGCA GGTGCTGTGC 1080

TGCCGCCTGT CGCTGCAGCA CGCCAACCAC GAGAAGCGCC TGCGCGTACA TGCGCACTCC 1140

ACCACCGACA GCGCCCGCTT TGTGCAGCGC CCGTTGCTCT TCGCGTCCCG GCGCCAGTCC 1200

TCTGCAAGGA GAACTGAGAA GATTTTCTTA AGCACTTTTC AGAGCGAGGC CGAGCCCCAG 1260

TCTAAGTCCC AGTCATTGAG TCTCGAGTCA CTAGAGCCCA ACTCAGGCGC GAAACCAGCC 1320 AATTCTGCTG CAGAGAATGG TTTTCAGGAG CATGAAGTTT GA

Seq ID NO: 399 Protein sequence Protein Accession ft: NP 001499.1

1 11 21 31 41 51 i i i ] i i

MASPSLPGSD CSQIIDHSHV PEFEVATWIK ITLILVYLII FVMGLLGNSV TIRVTQVLQK 60

KGYLQKEVTD HMVSLACSDI LVFLIGMPME FYSIIWNPLT TSSYTLSCKL HTFLFEACSY 120

ATLLHVLTLS FERYIAICHP FRYKAVSGPC QVKLLIGFVW VTSALVALPL LFAMGTEYPL 180

VNVPSHRGLT CNRSSTRHHE QPETSNMSIC TNLSSRWTVF QSSIFGAFW YLWLLSVAF 240 MCWNMMQVLM KSQKGSLAGG TRPPQLRKSE SEESRTARRQ TIIFLRLIW TLAVCWMPNQ 300

IRRIMAAAKP KHDWTRSYFR AYMILLPFSE TFFYLSSVIN PLLYTVSSQQ FRRVFVQVLC 360

CRLSLQHANH EKRLRVHAHS TTDSARFVQR PLLFASRRQS SARRTEKIFL STFQSEAEPQ 420 SKSQSLSLES LEPNSGAKPA NSAAENGFQE HEV

Seq ID NO: 400 DNA sequence

Nucleic Acid Accession ft: NM_006475.1

Coding sequence: 28..2538 1 11 21 31 41 51 i i i i i i

AACAGAACTG CAACGGAGAG ACTCAAGATG ATTCCCTTTT TACCCATGTT TTCTCTACTA 60

TTGCTGCTTA TTGTTAACCC TATAAACGCC AACAATCATT ATGACAAGAT CTTGGCTCAT 120

AGTCGTATCA GGGGTCGGGA CCAAGGCCCA AATGTCTGTG CCCTTCAACA GATTTTGGGC 180

ACCAAAAAGA AATACTTCAG CACTTGTAAG AACTGGTATA AAAAGTCCAT CTGTGGACAG 240 AAAACGACTG TTTTATATGA ATGTTGCCCT GGTTATATGA GAATGGAAGG AATGAAAGGC 300

TGCCCAGCAG TTTTGCCCAT TGACCATGTT TATGGCACTC TGGGCATCGT GGGAGCCACC 360

ACAACGCAGC GCTATTCTGA CGCCTCAAAA CTGAGGGAGG AGATCGAGGG AAAGGGATCC 420

TTCACTTACT TTGCACCGAG TAATGAGGCT TGGGACAACT TGGATTCTGA TATCCGTAGA 480

GGTTTGGAGA GCAACGTGAA TGTTGAATTA CTGAATGCTT TACATAGTCA CATGATTAAT 540

AAGAGAATGT TGACCAAGGA CTTAAAAAAT GGCATGATTA TTCCTTCAAT GTA AACAAT 600

TTGGGGCTTT TCATTAACCA TTATCCTAAT GGGGTTGTCA CTGTTAATTG TGCTCGAATC 660

ATCCATGGGA ACCAGATTGC AACAAATGGT GTTGTCCATG TCATTGACCG TGTGCTTACA 720

CAAATTGGTA CCTCAATTCA AGACTTCATT GAAGCAGAAG ATGACCTTTC ATCTTTTAGA 780 GCAGCTGCCA TCACATCGGA CATATTGGAG GCCCTTGGAA GAGACGGTCA CTTCACACTC 840 TTTGCTCCCA CCAATGAGGC TTTTGAGAAA CTTCCACGAG GTGTCCTAGA AAGGTTCATG 900

GGAGACAAAG TGGCTTCCGA AGCTCTTATG AAGTACCACA TCTTAAATAC TCTCCAGTGT 960

TCTGAGTCTA TTATGGGAGG AGCAGTCTTT GAGACGCTGG AAGGAAATAC AATTGAGATA 1020 GGATGTGACG GTGACAGTAT AACAGTAAAT GGAATCAAAA TGGTGAACAA AAAGGATATT 1080 GTGACAAATA ATGGTGTGAT CCATTTGATT GATCAGGTCC TAATTCCTGA TTCTGCCAAA 1140 CAAGTTATTG AGCTGGCTGG AAAACAGCAA ACCACCTTCA CGGATCTTGT GGCCCAATTA 1200 GGCTTGGCAT CTGCTCTGAG GCCAGATGGA GAATACACTT TGCTGGCACC TGTGAATAAT 1260 GCATTTTCTG ATGATACTCT CAGCATGGTT CAGCGCCTCC TTAAATTAAT TCTGCAGAAT 1320 CACATATTGA AAGTAAAAGT TGGCCTTAAT GAGCTTTACA ACGGGCAAAT ACTGGAAACC 1380 ATCGGAGGCA AACAGCTCAG AGTCTTCGTA TATCGTACAG CTGTCTGCAT TGAAAATTCA 1440 TGCATGGAGA AAGGGAGTAA GCAAGGGAGA AACGGTGCGA TTCACATATT CCGCGAGATC 1500 ATCAAGCCAG CAGAGAAATC CCTCCATGAA AAGTTAAAAC AAGATAAGCG CTTTAGCACC 1560 TTCCTCAGCC TACTTGAAGC TGCAGACTTG AAAGAGCTCC TGACACAACC TGGAGACTGG 1620 ACATTATTTG TGCCAACCAA TGATGCTTTT AAGGGAATGA CTAGTGAAGA AAAAGAAATT 1680 CTGATACGGG ACAAAAATGC TCTTCAAAAC ATCATTCTTT ATCACCTGAC ACCAGGAGTT 1740 TTCATTGGAA AAGGATTTGA ACCTGGTGTT ACTAACATTT TAAAGACCAC ACAAGGAAGC 1800 AAAATCTTTC TGAAAGAAGT AAATGATACA CTTCTGGTGA ATGAATTGAA ATCAAAAGAA 1860 TCTGACATCA TGACAACAAA TGGTGTAATT CATGTTGTAG ATAAACTCCT CTATCCAGCA 1920 GACACACCTG TTGGAAATGA TCAACTGCTG GAAATACTTA ATAAATTAAT CAAATACATC 1980 CAAATTAAGT TTGTTCGTGG TAGCACCTTC AAAGAAATCC CCGTGACTGT CTATACAACT 2040 AAAATTATAA CCAAAGTTGT GGAACCAAAA ATTAAAGTGA TTGAAGGCAG TCTTCAGCCT 2100 ATTATCAAAA CTGAAGGACC CACACTAACA AAAGTCAAAA TTGAAGGTGA ACCTGAATTC 2160 AGACTGATTA AAGAAGGTGA AACAATAACT GAAGTGATCC ATGGAGAGCC AATTATTAAA 2220 AAATACACCA AAATCATTGA TGGAGTGCCT GTGGAAATAA CTGAAAAAGA GACACGAGAA 2280 GAACGAATCA TTACAGGTCC TGAAATAAAA TACACTAGGA TTTCTACTGG AGGTGGAGAA 2340 ACAGAAGAAA CTCTGAAGAA ATTGTTACAA GAAGAGGTCA CCAAGGTCAC CAAATTCATT 2400 GAAGGTGGTG ATGGTCATTT ATTTGAAGAT GAAGAAATTA AAAGACTGCT TCAGGGAGAC 2460 ACACCCGTGA GGAAGTTGCA AGCCAACAAA AAAGTTCAAG GTTCTAGAAG ACGATTAAGG 2520 GAAGGTCGTT CTCAGTGAAA ATCCAAAAAC CAGAAAAAAA TGTTTATACA ACCCTAAGTC 2580 AATAACCTGA CCTTAGAAAA TTGTGAGAGC CAAGTTGACT TCAGGAACTG AAACATCAGC 2640 ACAAAGAAGC AATCATCAAA TAATTCTGAA CACAAATTTA ATATTTTTTT TTCTGAATGA 2700 GAAACATGAG GGAAATTGTG GAGTTAGCCT CCTGTGGTAA AGGAATTGAA GAAAATATAA 2760 CACCTTACAC CCTTTTTCAT CTTGACATTA AAAGTTCTGG CTAACTTTGG AATCCATTAG 2820 AGAAAAATCC TTGTCACCAG ATTCATTACA ATTCAAATCG AAGAGTTGTG AACTGTTATC 2880 CCATTGAAAA GACCGAGCCT TGTATGTATG TTATGGATAC ATAAAATGCA CGCAAGCCAT 2940 TATCTCTCCA TGGGAAGCTA AGTTATAAAA ATAGGTGCTT GGTGTACAAA ACTTTTTATA 3000 TCAAAAGGCT TTGCACATTT CTATATGAGT GGGTTTACTG GTAAATTATG TTATTTTTTA 3060 CAACTAATTT TGTACTCTCA GAATGTTTGT CATATGCTTC TTGCAATGCA TATTTTTTAA 3120 TCTCAAACGT TTCAATAAAA CCATTTTTCA GATATAAAGA GAATTACTTC AAATTGAGTA 3180 ATTCAGAAAA ACTCAAGATT TAAGTTAAAA AGTGGTTTGG ACTTGGGAA

Seq ID NO: 401 Protein sequence Protein Accession ft: NP 006466.1

MIPFLPMFSL LLLLIVNPIN ANNHYDKILA HSRIRGRDQG PNVCALQQIL GTKKKYFSTC 60

KNWYKKSICG QKTTVLYECC PGYMRMEGMK GCPAVLPIDH VYGTLGIVGA TTTQRYSDAS 120

KLREEIEGKG SFTYFAPSNE AWDNLDSDIR RGLESNVNVE LLNALHSHMI NKRMLTKDLK 180

NGMIIPSMYN NLGLFINHYP NGWTVNCAR IIHGNQIATN GWHVIDRVL TQIGTSIQDF 240

IEAEDDLSSF RAAAITSDIL EALGRDGHPT LFAPTNEAFE KLPRGVLERF MGDKVASEAL 300

MKYHILNTLQ CSESIMGGAV FETLEGNTIE IGCDGDSITV NGIKMVNKKD IVTNNGVIHL 360

IDQVLIPDSA KQVIELAGKQ QTTFTDLVAQ LGLASALRPD GEYTLLAPVN NAFSDDTLSM 420

VQRLLK ILQ NHILKVKVGL NELYNGQILE TIGGKQLRVF VYRTAVCIEN SCMEKGSKQG 480

RNGAIHIFRE IIKPAEKSLH EKLKQDKRFS TFLSLLEAAD LKELLTQPGD WTLFVPTNDA 540

FKGMTSEEKE ILIRDKNALQ NIILYHLTPG VFIGKGFEPG VTNILKTTQG SKIFLKEVND 600

TLLVNELKSK ESDIMTTNGV IHWDKLLYP ADTPVGNDQL LEILNKLIKY IQIKFVRGST 660

FKEIPVTVYT TKIITK EP KIKVIEGSLQ PIIKTEGPTL TKVKIEGEPE FRLIKEGETI 720

TEVIHGEPII KKYTKIIDGV PVEITEKETR EERIITGPEI KYTRISTGGG ETEETLKKLL 780

QEEVTKVTKF IEGGDGHLFE DEEIKRLLQG DTPVRKLQAN KKVQGSRRRL REGRSQ

Seq ID NO: 402 DNA sequence Nucleic Acid Accession ft: NM_002416 Coding sequence: 40..417

60

120

AAGGGTCGCT GTTCCTGCAT CAGCACCAAC CAAGGGACTA TCCACCTACA ATCCTTGAAA 180

GACCTTAAAC AATTTGCCCC AAGCCCTTCC TGCGAGAAAA TTGAAATCAT TGCTACACTG 240

AAGAATGGAG TTCAAACATG TCTAAACCCA GATTCAGCAG ATGTGAAGGA ACTGATTAAA 300

AAGTGGGAGA AACAGGTCAG CCAAAAGAAA AAGCAAAAGA ATGGGAAAAA ACATCAAAAA 360

AAGAAAGTTC TGAAAGTTCG AAAATCTCAA CGTTCTCGTC AAAAGAAGAC TACATAAGAG 420

ACCACTTCAC CAATAAGTAT TCTGTGTTAA AAATGTTCTA TTTTAATTAT ACCGCTATCA 480

TTCCAAAGGA GGATGGCATA TAATACAAAG GCTTATTAAT TTGACTAGAA AATTTAAAAC 540

ATTACTCTGA AATTGTAACT AAAGTTAGAA AGTTGATTTT AAGAATCCAA ACGTTAAGAA 600

TTGTTAAAGG CTATGATTGT CTTTGTTCTT CTACCACCCA CCAGTTGAAT TTCATCATGC 660

TTAAGGCCAT GATTTTAGCA ATACCCATGT CTACACAGAT GTTCACCCAA CCACATCCCA 720

CTCACAACAG CTGCCTGGAA GAGCAGCCCT AGGCTTCCAC GTACTGCAGC CTCCAGAGAG 780

TATCTGAGGC ACATGTCAGC AAGTCCTAAG CCTGTTAGCA TGCTGGTGAG CCAAGCAGTT 840

TGAAATTGAG CTGGACCTCA CCAAGCTGCT GTGGCCATCA ACCTCTGTAT TTGAATCAGC 900

CTACAGGCCT CACACACAAT GTGTCTGAGA GATTCATGCT GATTGTTATT GGGTATCACC 960

ACTGGAGATC ACCAGTGTGT GGCTTTCAGA GCCTCCTTTC TGGCTTTGGA AGCCATGTGA 1020

TTCCATCTTG CCCGCTCAGG CTGACCACTT TATTTCTTTT TGTTCCCCTT TGCTTCATTC 1080

AAGTCAGCTC TTCTCCATCC TACCACAATG CAGTGCCTTT CTTCTCTCCA GTGCACCTGT 1140

CATATGCTCT GATTTATCTG AGTCAACTCC TTTCTCATCT TGTCCCCAAC ACCCCACAGA 1200

AGTGCTTTCT TCTCCCAATT CATCCTCACT CAGTCCAGCT TAGTTCAAGT CGTGCCTCTT 1260

AAATAAACCT TTTTGGACAC ACAAATTATC TTAAAACTCC TGTTTCACTT GGTTCAGTAC 1320

CACATGGGTG AACACTCAAT GGTTAACTAA TTCTTGGGTG TTTATCCTAT CTCTCCAACC 1380 AGATTGTCAG CTCCTTGAGG GCAAGAGCCA CAGTATATTT CCCTGTTTCT TCCACAGTGC 1440

CTAATAATAC TGTGGAACTA GGTTTTAATA ATTTTTTAAT TGATGTTGTT ATGGGCAGGA 1500

TGGCAACCAG ACCATTGTCT CAGAGCAGGT GCTGGCTCTT TCCTGGCTAC TCCATGTTGG 1560

CTAGCCTCTG GTAACCTCTT ACTTATTATC TTCAGGACAC TCACTACAGG GACCAGGGAT 1620

GATGCAACAT CCTTGTCTTT TTATGACAGG ATGTTTGCTC AGCTTCTCCA ACAATAAGAA 1680

GCACGTGGTA AAACACTTGC GGATATTCTG GACTGTTTTT AAAAAATATA CAGTTTACCG 1740

AAAATCATAT AATCTTACAA TGAAAAGGAC TTTATAGATC AGCCAGTGAC CAACCTTTTC 1800

CCAACCATAC AAAAATTCCT TTTCCCGAAG GAAAAGGGCT TTCTCAATAA GCCTCAGCTT 1860

TCTAAGATCT AACAAGATAG CCACCGAGAT CCTTATCGAA ACTCATTTTA GGCAAATATG 1920

AGTTTTATTG TCCGTTTACT TGTTTCAGAG TTTGTATTGT GATTATCAAT TACCACACCA 1980

TCTCCCATGA AGAAAGGGAA CGGTGAAGTA CTAAGCGCTA GAGGAAGCAG CCAAGTCGGT 2040

TAGTGGAAGC ATGATTGGTG CCCAGTTAGC CTCTGCAGGA TGTGGAAACC TCCTTCCAGG 2100

GGAGGTTCAG TGAATTGTGT AGGAGAGGTT GTCTGTGGCC AGAATTTAAA CCTATACTCA 2160

CTTTCCCAAA TTGAATCACT GCTCACACTG CTGATGATTT AGAGTGCTGT CCGGTGGAGA 2220

TCCCACCCGA ACGTCTTATC TAATCATGAA ACTCCCTAGT TCCTTCATGT AACTTCCCTG 2280

AAAAATCTAA GTGTTTCATA AATTTGAGAG TCTGTGACCC ACTTACCTTG CATCTCACAG 2340

GTAGACAGTA TATAACTAAC AACCAAAGAC TACATATTGT CACTGACACA CACGTTATAA 2400

TCATTTATCA TATATATACA TACATGCATA CACTCTCAAA GCAAATAATT TTTCACTTCA 2460

AAACAGTATT GACTTGTATA CCTTGTAATT TGAAATATTT TCTTTGTTAA AATAGAATGG 2520 TATCAATAAA TAGACCATTA ATCAG

Seq ID NO: 403 Protein sequence Protein Accession ft: NP_002407

1 11 21 31 41 51

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MKKSGVLFLL GIILLVLIGV QGTPWRKGR CSCISTNQGT IHLQSLKDLK QFAPSPSCEK 60 IEIIATLKNG VQTCLNPDSA DVKELIKKWE KQVSQKKKQK NGKKHQKKKV LKVRKSQRSR 120 QKKTT

Seq ID NO: 404 DNA sequence

Nucleic Acid Accession ft: NM_006670

Coding sequence: 85..1347

11 21 31 41 51

CCGGCTCGCG CCCTCCGGGC CCAGGCTCCC GAGCCTTCGG AGCGGGCGCC GTCCCAGCCC 60 AGCTCCGGGG AAACGCGAGC CGCGATGCCT GGGGGGTGCT CCCGGGGCCC CGCCGCCGGG 120 GACGGGCGTC TGCGGCTGGC GCGACTAGCG CTGGTACTCC TGGGCTGGGT CTCCTCGTCT 180 TCTCCCACCT CCTCGGCATC CTCCTTCTCC TCCTCGGCGC CGTTCCTGGC TTCCGCCGTG 240 TCCGCCCAGC CCCCGCTGCC GGACCAGTGC CCCGCGCTGT GCGAGTGCTC CGAGGCAGCG 300 CGCACAGTCA AGTGCGTTAA CCGCAATCTG ACCGAGGTGC CCACGGACCT GCCCGCCTAC 360 GTGCGCAACC TCTTCCTTAC CGGCAACCAG CTGGCCGTGC TCCCTGCCGG CGCCTTCGCC 420 CGCCGGCCGC CGCTGGCGGA GCTGGCCGCG CTCAACCTCA GCGGCAGCCG CCTGGACGAG 480 GTGCGCGCGG GCGCCTTCGA GCATCTGCCC AGCCTGCGCC AGCTCGACCT CAGCCACAAC 540 CCACTGGCCG ACCTCAGTCC CTTCGCTTTC TCGGGCAGCA ATGCCAGCGT CTCGGCCCCC 600 AGTCCCCTTG TGGAACTGAT CCTGAACCAC ATCGTGCCCC CTGAAGATGA GCGGCAGAAC 660 CGGAGCTTCG AGGGCATGGT GGTGGCGGCC CTGCTGGCGG GCCGTGCACT GCAGGGGCTC 720 CGCCGCTTGG AGCTGGCCAG CAACCACTTC CTTTACCTGC CGCGGGATGT GCTGGCCCAA 780 CTGCCCAGCC TCAGGCACCT GGACTTAAGT AATAATTCGC TGGTGAGCCT GACCTACGTG 840 TCCTTCCGCA ACCTGACACA TCTAGAAAGC CTCCACCTGG AGGACAATGC CCTCAAGGTC 900 CTTCACAATG GCACCCTGGC TGAGTTGCAA GGTCTACCCC ACATTAGGGT TTTCCTGGAC 960 AACAATCCCT GGGTCTGCGA CTGCCACATG GCAGACATGG TGACCTGGCT CAAGGAAACA 1020 GAGGTAGTGC AGGGCAAAGA CCGGCTCACC TGTGCATATC CGGAAAAAAT GAGGAATCGG 1080 GTCCTCTTGG AACTCAACAG TGCTGACCTG GACTGTGACC CGATTCTTCC CCCATCCCTG 1140 CAAACCTCTT ATGTCTTCCT GGGTATTGTT TTAGCCCTGA TAGGCGCTAT TTTCCTCCTG 1200 GTTTTGTATT TGAACCGCAA GGGGATAAAA AAGTGGATGC ATAACATCAG AGATGCCTGC 1260 AGGGATCACA TGGAAGGGTA TCATTACAGA TATGAAATCA ATGCGGACCC CAGATTAACA 1320 AACCTCAGTT CTAACTCGGA- TGTCTGAGAA ATATTAGAGG ACAGACCAAG GACAACTCTG 1380 CATGAGATGT AGACTTAAGC TTTATCCCTA CTAGGCTTGC TCCACTTTCA TCCTCCACTA 1440 TAGATACAAC GGACTTTGAC TAAAAGCAGT GAAGGGGATT TGCTTCCTTG TTATGTAAAG 1500 TTTCTCGGTG TGTTCTGTTA ATGTAAGACG ATGAACAGTT GTGTATAGTG TTTTACCCTC 1560 TTCTTTTTCT TGGAACTCCT CAACACGTAT GGAGGGATTT TTCAGGTTTC AGCATGAACA 1620 TGGGCTTCTT GCTGTCTGTC TCTCTCTCAG TACAGTTCAA GGTGTAGCAA GTGTACCCAC 1680 ACAGATAGCA TTCAACAAAA GCTGCCTCAA CTTTTTCGAG AAAAATACTT TATTCATAAA 1740 TATCAGTTTT ATTCTCATGT ACCTAAGTTG TGGAGAAAAT AATTGCATCC TATAAACTGC 1800 CTGCAGACGT TAGCAGGCTC TTCAAAATAA CTCCATGGTG CACAGGAGCA CCTGCATCCA 1860 AGAGCATGCT TACATTTTAC TGTTCTGCAT ATTACAAAAA ATAACTTGCA ACTTCATAAC 1920 TTCTTTGACA AAGTAAATTA CTTTTTTGAT TGCAGTTTAT ATGAAAATGT ACTGATTTTT 1980 TTTTAATAAA CTGCATCGAG ATCCAACCGA CTGAATTGTT AAAAAAAAAA AAAAATAAAG 2040 ATTCTTAAAA GAA

Seq ID NO: 405 Protein sequence Protein Accession ft: NP 006661

11 21 31 41 51

MPGGCSRGPA A IGDGRLRLAR LALVLLGWVS SSSPTSSASS F ISSSAPFLAS A IVSAQPPLPD 60 QCPALCECSE AARTVKCVNR NLTEVPTDLP AYVRNLFLTG NQLAVLPAGA FARRPPLAEL 120 AALNLSGSRL DEVRAGAFEH LPSLRQLDLS HNPLADLSPF AFSGSNASVS APSPLVELIL 180 NHIVPPEDER QNRSFEGMW AALLAGRALQ GLRRLELASN HFLYLPRDVL AQLPSLRHLD 240 LSNNSLVSLT YVSFRNLTHL ESLHLEDNAL KVLHNGTLAE LQGLPHIRVF LDNNPWVCDC 300 HMADMVTWLK ETEWQGKDR LTCAYPEKMR NRVLLELNSA DLDCDPILPP SLQTSYVFLG 360 IVLALIGAIF LLVLYLNRKG IKKWMHNIRD ACRDHMEGYH YRYEINADPR LTNLSSNSDV

Seq ID NO: 406 DNA sequence

Nucleic Acid Accession ft: Eos sequence Coding sequence: 1..927

1 11 21 31 41 51

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ATGCCTGGGG GGTGCTCCCG GGGCCCCGCC GCCGGGGACG GGCGTCTGCG GCTGGCGCGA 60

CTAGCGCTGG TACTCCTGGG CTGGGTCTCC TCGTCTTCTC CCACCTCCTC GGCATCCTCC 120

TTCTCCTCCT CGGCGCCGTT CCTGGCTTCC GCCGTGTCCG CCCAGCCCCC GCTGCCGGAC 180

CAGTGCCCCG CGCTGTGCGA GTGCTCCGAG GCAGCGCGCA CAGTCAAGTG CGTTAACCGC 240

AATCTGACCG AGGTGCCCAC GGACCTGCCC GCCTACGTGC GCAACCTCTT CCTTACCGGC 300

AACCAGCTGG CCAGCAACCA CTTCCTTTAC CTGCCGCGGG ATGTGCTGGC CCAACTGCCC 360

AGCCTCAGGC ACCTGGACTT AAGTAATAAT TCGCTGGTGA GCCTGACCTA CGTGTCCTTC 420

CGCAACCTGA CACATCTAGA AAGCCTCCAC CTGGAGGACA ATGCCCTCAA GGTCCTTCAC 480

AATGGCACCC TGGCTGAGTT GCAAGGTCTA CCCCACATTA GGGTTTTCCT GGACAACAAT 540

CCCTGGGTCT GCGACTGCCA CATGGCAGAC ATGGTGACCT GGCTCAAGGA AACAGAGGTA 600

GTGCAGGGCA AAGACCGGCT CACCTGTGCA TATCCGGAAA AAATGAGGAA TCGGGTCCTC 660

TTGGAACTCA ACAGTGCTGA CCTGGACTGT GACCCGATTC TTCCCCCATC CCTGCAAACC 720

TCTTATGTCT TCCTGGGTAT TGTTTTAGCC CTGATAGGCG CTATTTTCCT CCTGGTTTTG 780

TATTTGAACC GCAAGGGGAT AAAAAAGTGG ATGCATAACA TCAGAGATGC CTGCAGGGAT 840

CACATGGAAG GGTATCATTA CAGATATGAA ATCAATGCGG ACCCCAGATT AACAAACCTC 900 AGTTCTAACT CGGATGTCCT CGAGTGA

Seq ID NO: 407 Protein sequence Protein Accession ft: Eos sequence

1 11 21 31 41 51

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MPGGCSRGPA AGDGRLRLAR LALVLLGWVS SSSPTSSASS FSSSAPFLAS AVSAQPPLPD 60

QCPALCECSE AARTVKCVNR NLTEVPTDLP AYVRNLFLTG NQLASNHFLY LPRDVLAQLP 120

SLRHLDLSNN SLVSLTYVSF RNLTHLESLH LEDNALKVLH NGTLAELQGL PHIRVFLDNN 180

PWVCDCHMAD MVTWLKETEV VQGKDRLTCA YPEKMRNRVL LELNSADLDC DPILPPSLQT 240

SYVFLGIVLA LIGAIFLLVL YLNRKGIKKW MHNIRDACRD HMEGYHYRYE INADPRLTNL 300 SSNSDVLE

Seq ID NO: 408 DNA sequence Nucleic Acid Accession ft: NM 000095.1

Coding sequence: 26..2299

1 11 21 31 41 51

I I I I I I

CAGCACCCAG CTCCCCGCCA CCGCCATGGT CCCCGACACC GCCTGCGTTC TTCTGCTCAC 60

CCTGGCTGCC CTCGGCGCGT CCGGACAGGG CCAGAGCCCG TTGGGCTCAG ACCTGGGCCC 120

GCAGATGCTT CGGGAACTGC AGGAAACCAA CGCGGCGCTG CAGGACGTGC GGGACTGGCT 180

GCGGCAGCAG GTCAGGGAGA TCACGTTCCT GAAAAACACG GTGATGGAGT GTGACGCGTG 240

CGGGATGCAG CAGTCAGTAC GCACCGGCCT ACCCAGCGTG CGGCCCCTGC TCCACTGCGC 300

GCCCGGCTTC TGCTTCCCCG GCGTGGCCTG CATCCAGACG GAGAGCGGCG GCCGCTGCGG 360

CCCCTGCCCC GCGGGCTTCA CGGGCAACGG CTCGCACTGC ACCGACGTCA ACGAGTGCAA 420

CGCCCACCCC TGCTTCCCCC GAGTCCGCTG TATCAACACC AGCCCGGGGT TCCGCTGCGA 480

GGCTTGCCCG CCGGGGTACA GCGGCCCCAC CCACCAGGGC GTGGGGCTGG CTTTCGCCAA 540

GGCCAACAAG CAGGTTTGCA CGGACATCAA CGAGTGTGAG ACCGGGCAAC ATAACTGCGT 600

CCCCAACTCC GTGTGCATCA ACACCCGGGG CTCCTTCCAG TGCGGCCCGT GCCAGCCCGG 660

CTTCGTGGGC GACCAGGCGT CCGGCTGCCA GCGCGGCGCA CAGCGCTTCT GCCCCGACGG 720

CTCGCCCAGC GAGTGCCACG AGCATGCAGA CTGCGTCCTA GAGCGCGATG GCTCGCGGTC 780

GTGCGTGTGT CGCGTTGGCT GGGCCGGCAA CGGGATCCTC TGTGGTCGCG ACACTGACCT 840

AGACGGCTTC CCGGACGAGA AGCTGGGCTG CCCGGAGCCG CAGTGCCGTA AGGACAACTG 900

CGTGACTGTG CCCAACTCAG GGCAGGAGGA TGTGGACCGC GATGGCATCG GAGACGCCTG 960

CGATCCGGAT GCCGACGGGG ACGGGGTCCC CAATGAAAAG GACAACTGCC CGCTGGTGCG 1020

GAACCCAGAC CAGCGCAACA CGGACGAGGA CAAGTGGGGC GATGCGTGCG ACAACTGCCG 1080

GTCCCAGAAG AACGACGACC AAAAGGACAC AGACCAGGAC GGCCGGGGCG ATGCGTGCGA 1140

CGACGACATC GACGGCGACC GGATCCGCAA CCAGGCCGAC AACTGCCCTA GGGTACCCAA 1200

CTCAGACCAG AAGGACAGTG ATGGCGATGG TATAGGGGAT GCCTGTGACA ACTGTCCCCA 1260

GAAGAGCAAC CCGGATCAGG CGGATGTGGA CCACGACTTT GTGGGAGATG CTTGTGACAG 1320

CGATCAAGAC CAGGATGGAG ACGGACATCA GGACTCTCGG GACAACTGTC CCACGGTGCC 1380

TAACAGTGCC CAGGAGGACT CAGACCACGA TGGCCAGGGT GATGCCTGCG ACGACGACGA 1440

CGACAATGAC GGAGTCCCTG ACAGTCGGGA CAACTGCCGC CTGGTGCCTA ACCCCGGCCA 1500

GGAGGACGCG GACAGGGACG GCGTGGGCGA CGTGTGCCAG GACGACTTTG ATGCAGACAA 1560

GGTGGTAGAC AAGATCGACG TGTGTCCGGA GAACGCTGAA GTCACGCTCA CCGACTTCAG 1620

GGCCTTCCAG ACAGTCGTGC TGGACCCGGA GGGTGACGCG CAGATTGACC CCAACTGGGT 1680

GGTGCTCAAC CAGGGAAGGG AGATCGTGCA GACAATGAAC AGCGACCCAG GCCTGGCTGT 1740

GGGTTACACT GCCTTCAATG GCGTGGACTT CGAGGGCACG TTCCATGTGA ACACGGTCAC 1800

GGATGACGAC TATGCGGGCT TCATCTTTGG CTACCAGGAC AGCTCCAGCT TCTACGTGGT 1860

CATGTGGAAG CAGATGGAGC AAACGTATTG GCAGGCGAAC CCCTTCCGTG CTGTGGCCGA 1920

GCCTGGCATC CAACTCAAGG CTGTGAAGTC TTCCACAGGC CCCGGGGAAC AGCTGCGGAA 1980

CGCTCTGTGG CATACAGGAG ACACAGAGTC CCAGGTGCGG CTGCTGTGGA AGGACCCGCG 2040

AAACGTGGGT TGGAAGGACA AGAAGTCCTA TCGTTGGTTC CTGCAGCACC GGCCCCAAGT 2100

GGGCTACATC AGGGTGCGAT TCTATGAGGG CCCTGAGCTG GTGGCCGACA GCAACGTGGT 2160

CTTGGACACA ACCATGCGGG GTGGCCGCCT GGGGGTCTTC TGCTTCTCCC AGGAGAACAT 2220

CATCTGGGCC AACCTGCGTT ACCGCTGCAA TGACACCATC CCAGAGGACT ATGAGACCCA 2280

TCAGCTGCGG CAAGCCTAGG GACCAGGGTG AGGACCCGCC GGATGACAGC CACCCTCACC 2340

GCGGCTGGAT GGGGGCTCTG CAGCCAGCCC AAGGGGTGGC CGTCCTGAGG GGGAAGTGAG 2400 AAGGGCTCAG AGAGGACAAA ATAAAGTGTG TGTGCAGGG

Seq ID NO: 409 Protein sequence Protein Accession ft: NP_000086.1

1 11 21 31 41 51

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MVPDTACVLL LTLAALGASG QGQSPLGSDL GPQMLRELQE TNAALQDVRD WLRQQVREIT 60 FLKNTVMECD ACGMQQSVRT GLPSVRPLLH CAPGFCFPGV ACIQTESGGR CGPCPAGFTG 120 NGSHCTDVNE CNAHPCFPRV RCINTSPGFR CEACPPGYSG PTHQGVGLAF AKANKQVCTD 180 INECETGQHN CVPNSVCINT RGSFQCGPCQ PGPVGDQASG CQRGAQRFCP DGSPSECHEH 240 ADCVLERDGS RSCVCRVGWA GNGILCGRDT DLDGFPDEKL RCPEPQCRKD NCVTVPNSGQ 300 EDVDRDGIGD ACDPDADGDG VPNEKDNCPL VRNPDQRNTD EDKWGDACDN CRSQKNDDQK 360 DTDQDGRGDA CDDDIDGDRI RNQADNCPRV PNSDQKDSDG DGIGDACDNC PQKSNPDQAD 420 VDHDFVGDAC DSDQDQDGDG HQDSRDNCPT VPNSAQEDSD HDGQGDACDD DDDNDGVPDS 480 RDNCRLVPNP GQEDADRDGV GDVCQDDFDA DKWDKIDVC PENAEVTLTD FRAFQTWLD 540 PEGDAQIDPN WWLNQGREI VQTMNSDPGL AVGYTAFNGV DFEGTFHVNT VTDDDYAGFI 600 FGYQDSSSFY WMWKQMEQT YWQANPFRAV AEPGIQLKAV KSSTGPGEQL RNALWHTGDT 660 ESQVRLLWKD PRNVGWKDKK SYRWFLQHRP QVGYIRVRFY EGPELVADSN WLDTTMRGG 720 RLGVFCFSQE NIIWANLRYR CNDTIPEDYE THQLRQA

Seq ID NO: 410 DNA sequence

Nucleic Acid Accession ft: NM_001565.1

Coding sequence: 67..363

11 21 31 41 51

I I I I I

GAGACATTCC TCAATTGCTT AGACATATTC TGAGCCTACA GCAGAGGAAC CTCCAGTCTC 60 AGCACCATGA ATCAAACTGC GATTCTGATT TGCTGCCTTA TCTTTCTGAC TCTAAGTGGC 120 ATTCAAGGAG TACCTCTCTC TAGAACCGTA CGCTGTACCT GCATCAGCAT TAGTAATCAA 180 CCTGTTAATC CAAGGTCTTT AGAAAAACTT GAAATTATTC CTGCAAGCCA ATTTTGTCCA 240 CGTGTTGAGA TCATTGCTAC AATGAAAAAG AAGGGTGAGA AGAGATGTCT GAATCCAGAA 300 TCGAAGGCCA TCAAGAATTT ACTGAAAGCA GTTAGCAAGG AAATGTCTAA AAGATCTCCT 360 TAAAACCAGA GGGGAGCAAA ATCGATGCAG TGCTTCCAAG GATGGACCAC ACAGAGGCTG 420 CCTCTCCCAT CACTTCCCTA CATGGAGTAT ATGTCAAGCC ATAATTGTTC TTAGTTTGCA 480 GTTACACTAA AAGGTGACCA ATGATGGTCA CCAAATCAGC TGCTACTACT CCTGTAGGAA 540 GGTTAATGTT CATCATCCTA AGCTATTCAG TAATAACTCT ACCCTGGCAC TATAATGTAA 600 GCTCTACTGA GGTGCTATGT TCTTAGTGGA TGTTCTGACC CTGCTTCAAA TATTTCCCTC 660 ACCTTTCCCA TCTTCCAAGG GTACTAAGGA ATCTTTCTGC TTTGGGGTTT ATCAGAATTC 720 TCAGAATCTC AAATAACTAA AAGGTATGCA ATCAAATCTG CTTTTTAAAG AATGCTCTTT 780 ACTTCATGGA CTTCCACTGC CATCCTCCCA AGGGGCCCAA ATTCTTTCAG TGGCTACCTA 840 CATACAATTC CAAACACATA CAGGAAGGTA GAAATATCTG AAAATGTATG TGTAAGTATT 900 CTTATTTAAT GAAAGACTGT ACAAAGTATA AGTCTTAGAT GTATATATTT CCTATATTGT 960 TTTCAGTGTA CATGGAATAA CATGTAATTA AGTACTATGT ATCAATGAGT AACAGGAAAA 1020 TTTTAAAAAT ACAGATAGAT ATATGCTCTG CATGTTACAT AAGATAAATG TGCTGAATGG 1080 TTTTCAAATA AAAATGAGGT ACTCTCCTGG AAATATTAAG

Seq ID NO: 411 Protein sequence Protein Accession ft: NP 001556.1

1 11 21 31 41 51

I I I I I I

MNQTAILICC LIFLTLSGIQ GVPLSRTVRC TCISISNQPV NPRSLEKLEI IPASQFCPRV 60 EIIATMKKKG EKRCLNPESK AIKNLLKAVS KEMSKRSP

Seq ID NO: 412 DNA sequence

Nucleic Acid Accession ft: XM_057014

Coding sequence: 143..874

11 21 31 41 51

GGGAGGGAGA GAGGCGCGCG GGTGAAAGGC GCATTGATGC AGCCTGCGGC GGCCTCGGAG 60 CGCGGCGGAG CCAGACGCTG ACCACGTTCC TCTCCTCGGT CTCCTCCGCC TCCAGCTCCG 120 CGCTGCCCGG CAGCCGGGAG CCATGCGACC CCAGGGCCCC GCCGCCTCCC CGCAGCGGCT 180 CCGCGGCCTC CTGCTGCTCC TGCTGCTGCA GCTGCCCGCG CCGTCGAGCG CCTCTGAGAT 240 CCCCAAGGGG AAGCAAAAGG CGCAGCTCCG GCAGAGGGAG GTGGTGGACC TGTATAATGG 300 AATGTGCTTA CAAGGGCCAG CAGGAGTGCC TGGTCGAGAC GGGAGCCCTG GGGCCAATGG 360 CATTCCGGGT ACACCTGGGA TCCCAGGTCG GGATGGATTC AAAGGAGAAA AGGGGGAATG 420 TCTGAGGGAA AGCTTTGAGG AGTCCTGGAC ACCCAACTAC AAGCAGTGTT CATGGAGTTC 480 ATTGAATTAT GGCATAGATC TTGGGAAAAT TGCGGAGTGT ACATTTACAA AGATGCGTTC 540 AAATAGTGCT CTAAGAGTTT TGTTCAGTGG CTCACTTCGG CTAAAATGCA GAAATGCATG 600 CTGTCAGCGT TGGTATTTCA CATTCAATGG AGCTGAATGT TCAGGACCTC TTCCCATTGA 660 AGCTATAATT TATTTGGACC AAGGAAGCCC TGAAATGAAT TCAACAATTA ATATTCATCG 720 CACTTCTTCT GTGGAAGGAC TTTGTGAAGG AATTGGTGCT GGATTAGTGG ATGTTGCTAT 780 CTGGGTTGGC ACTTGTTCAG ATTACCCAAA AGGAGATGCT TCTACTGGAT GGAATTCAGT 840 TTCTCGCATC ATTATTGAAG AACTACCAAA ATAAATGCTT TAATTTTCAT TTGCTACCTC 900 TTTTTTTATT ATGCCTTGGA ATGGTTCACT TAAATGACAT TTTAAATAAG TTTATGTATA 960 CATCTGAATG AAAAGCAAAG CTAAATATGT TTACAGACCA AAGTGTGATT TCACACTGTT 1020 TTTAAATCTA GCATTATTCA TTTTGCTTCA ATCAAAAGTG GTTTCAATAT TTTTTTTAGT 1080 TGGTTAGAAT ACTTTCTTCA TAGTCACATT CTCTCAACCT ATAATTTGGA ATATTGTTGT 1140 GGTCTTTTGT TTTTTCTCTT AGTATAGCAT TTTTAAAAAA ATATAAAAGC TACCAATCTT 1200 TGTACAATTT GTAAATGTTA AGAATTTTTT TTATATCTGT TAAATAAAAA TTATTTCCAA 1260 CAACCTTAAA AAAAAAAAAA AAAA

Seq ID NO: 413 Protein sequence Protein Accession ft: XP 057014

11 21 31 41 51

I 1 I I I I

MRPQGPAASP QRLRGLLLLL LLQLPAPSSA SEIPKGKQKA QLRQREWDL YNGMCLQGPA 60

GVPGRDGSPG ANGIPGTPGI PGRDGFKGEK GECLRESFEE SWTPNYKQCS WSSLNYGIDL 120

GKIAECTFTK MRSNSALRVL FSGSLRLKCR NACCQRWYFT FNGAECSGPL PIEAIIYLDQ 180

GSPEMNSTIN IHRTSSVEGL CEGIOAGLVD VAIWVGTCSD YPKGDASTGW NSVSRIIIEE 240

LPK Seq ID NO: 414 DNA sequence

Nucleic Acid Accession ft: XM_084007

Coding sequence: 138..2405

1 11 21 31 41 51

I I I I I I

CTCGTGCCGA ATTCGGCACG AGACCGCGTG TTCGCGCCTG GTAGAGATTT CTCGAAGACA 60

CCAGTGGGCC CGTGTGGAAC CAAACCTGCG CGCGTGGCCG GGCCGTGGGA CAACGAGGCC 120

GCGGAGACGA AGGCGCAATG GCGAGGAAGT TATCTGTAAT CTTGATCCTG ACCTTTGCCC 180

TCTCTGTCAC AAATCCCCTT CATGAACTAA AAGCAGCTGC TTTCCCCCAG ACCACTGAGA 240

AAATTAGTCC GAATTGGGAA TCTGGCATTA ATGTTGACTT GGCAATTTCC ACACGGCAAT 300

ATCATCTACA ACAGCTTTTC TACCGCTATG GAGAAAATAA TTCTTTGTCA GTTGAAGGGT 360

TCAGAAAATT ACTTCAAAAT ATAGGCATAG ATAAGATTAA AAGAATCCAT ATACACCATG 420

ACCACGACCA TCACTCAGAC CACGAGCATC ACTCAGACCA TGAGCGTCAC TCAGACCATG 480

AGCATCACTC AGACCACGAG CATCACTCTG ACCATGATCA TCACTCCCAC CATAATCATG 540

CTGCTTCTGG TAAAAATAAG CGAAAAGCTC TTTGCCCAGA CCATGACTCA GATAGTTCAG 600

GTAAAGATCC TAGAAACAGC CAGGGGAAAG GAGCTCACCG ACCAGAACAT GCCAGTGGTA 660

GAAGGAATGT CAAGGACAGT GTTAGTGCTA GTGAAGTGAC CTCAACTGTG TACAACACTG 720

TCTCTGAAGG AACTCACTTT CTAGAGACAA TAGAGACTCC AAGACCTGGA AAACTCTTCC 780

CCAAAGATGT AAGCAGCTCC ACTCCACCCA GTGTCACATC AAAGAGCCGG GTGAGCCGGC 840

TGGCTGGTAG GAAAACAAAT GAATCTGTGA GTGAGCCCCG AAAAGGCTTT ATGTATTCCA 900

GAAACACAAA TGAAAATCCT CAGGAGTGTT TCAATGCATC AAAGCTACTG ACATCTCATG 960

GCATGGGCAT CCAGGTTCCG CTGAATGCAA CAGAGTTCAA CTATCTCTGT CCAGCCATCA 1020

TCAACCAAAT TGATGCTAGA TCTTGTCTGA TTCATACAAG TGAAAAGAAG GCTGAAATCC 1080

CTCCAAAGAC CTATTCATTA CAAATAGCCT GGGTTGGTGG TTTTATAGCC ATTTCCATCA 1140

TCAGTTTCCT GTCTCTGCTG GGGGTTATCT TAGTGCCTCT CATGAATCGG GTGTTTTTCA 1200

AATTTCTCCT GAGTTTCCTT GTGGCACTGG CCGTTGGGAC TTTGAGTGGT GATGCTTTTT 1260

TACACCTTCT- TCCACATTCT CATGCAAGTC ACCACCATAG TCATAGCCAT GAAGAACCAG 1320

CAATGGAAAT GAAAAGAGGA CCACTTTTCA GTCATCTGTC TTCTCAAAAC ATAGAAGAAA 1380

GTGCCTATTT TGATTCCACG TGGAAGGGTC TAACAGCTCT AGGAGGCCTG TATTTCATGT 1440

TTCTTGTTGA ACATGTCCTC ACATTGATCA AACAATTTAA AGATAAGAAG AAAAAGAATC 1500

AGAAGAAACC TGAAAATGAT GATGATGTGG AGATTAAGAA GCAGTTGTCC AAGTATGAAT 1560

CTCAACTTTC AACAAATGAG GAGAAAGTAG ATACAGATGA TCGAACTGAA GGCTATTTAC 1620

GAGCAGACTC ACAAGAGCCC TCCCACTTTG ATTCTCAGCA GCCTGCAGTC TTGGAAGAAG 1680

AAGAGGTCAT GATAGCTCAT GCTCATCCAC AGGAAGTCTA CAATGAATAT GTACCCAGAG 1740

GGTGCAAGAA TAAATGCCAT TCACATTTCC ACGATACACT CGGCCAGTCA GACGATCTCA 1800

TTCACCACCA TCATGACTAC CATCATATTC TCCATCATCA CCACCACCAA AACCACCATC 1860

CTCACAGTCA CAGCCAGCGC TACTCTCGGG AGGAGCTGAA AGATGCCGGC GTCGCCACTT 1920

TGGCCTGGAT GGTGATAATG GGTGATGGCC TGCACAATTT CAGCGATGGC CTAGCAATTG 1980

CTGCTGCTTT TACTGAAGGC TTATCAAGTG GTTTAAGTAC TTCTGTTGCT GTGTTCTGTC 2040

ATGAGTTGCC TCATGAATTA GGTGACTTTG CTGTTCTACT AAAGGCTGGC ATGACCGTTA 2100

AGCAGGCTGT CCTTTATAAT GCATTGTCAG CCATGCTGGC GTATCTTGGA ATGGCAACAG 2160

GAATTTTCAT TGGTCATTAT GCTGAAAATG TTTCTATGTG GATATTTGCA CTTACTGCTG 2220

GCTTATTCAT GTATGTTGCT CTGGTTGATA TGGTACCTGA AATGCTGCAC AATGATGCTA 2280

GTGACCATGG ATGTAGCCQC TGGGGGTATT TCTTTTTACA GAATGCTGGG ATGCTTTTGG 2340

GTTTTGGAAT TATGTTACTT ATTTCCATAT TTGAACATAA AATCGTGTTT CGTATAAATT 2400

TCTAGTTAAG GTTTAAATGC TAGAGTAGCT TAAAAAGTTG TCATAGTTTC AGTAGGTCAT 2460

AGGGAGATGA GTTTGTATGC TGTACTATGC AGCGTTTAAA GTTAGTGGGT TTTGTGATTT 2520

TTGTATTGAA TATTGCTGTC TGTTACAAAG TCAGTTAAAG GTACGTTTTA ATATTTAAGT 2580

TATTCTATCT TGGAGATAAA ATCTGTATGT GCAATTCACC GGTATTACCA GTTTATTATG 2640

TAAACAAGAG ATTTGGCATG ACATGTTCTG TATGTTTCAG GGAAAAATGT CTTTAATGCT 2700

TTTTCAAGAA CTAACACAGT TATTCCTATA CTGGATTTTA GGTCTCTGAA GAACTGCTGG 2760

TGTTTAGGAA TAAGAATGTG CATGAAGCCT AAAATACCAA GAAAGCTTAT ACTGAATTTA 2820

AGCAAAGAAA TAAAGGAGAA AAGAGAAGAA TCTGAGAATT GGGGAGGCAT AGATTCTTAT 2880

AAAAATCACA AAATTTGTTG TAAATTAGAG GGGAGAAATT TAGAATTAAG TATAAAAAGG 2940

CAGAATTAGT ATAGAGTACA TTCATTAAAC ATTTTTGTCA GGATTATTTC CCGTAAAAAC 3000

GTAGTGAGCA CTCTCATATA CTAATTAGTG TACATTTAAC TTTGTATAAT ACAGAAATCT 3060

AAATATATTT AATGAATTCA AGCAATATAC ACTTGACCAA GAAATTGGAA TTTCAAAATG 3120

TTCGTGCGGG TTATATACCA GATGAGTACA GTGAGTAGTT TATGTATCAC CAGACTGGGT 3180

TATTGCCAAG TTATATATCA CCAAAAGCTG TATGACTGGA TGTTCTGGTT ACCTGGTTTA 3240

CAAAATTATC AGAGTAGTAA AACTTTGATA TATATGAGGA TATTAAAACT ACACTAAGTA 3300

TCATTTGATT CGATTCAGAA AGTACTTTGA TATCTCTCAG TGCTTCAGTG CTATCATTGT 3360

GAGCAATTGT CTTTATATAC GGTACTGTAG CCATACTAGG CCTGTCTGTG GCATTCTCTA 3420 GATGTTTCTT TTTTACACAA TAAATTCCTT ATATCAGCTT G

Seq ID NO: 415 Protein sequence Protein Accession ft: XP 084007 1 11 21 31 41 51 i i i i i i

MARKLSVILI LTFALSVTNP LHELKAAAFP QTTEKISPNW ESGINVDLAI STRQYHLQQL 60

FYRYGENNSL SVEGFRKLLQ NIGIDKIKRI HIHHDHDHHS DHEHHSDHER HSDHEHHSDH 120

EHHSDHDHHS HHNHAASGKN KRKALCPDHD SDSSGKDPRN SQGKGAHRPE HASGRRNVKD 180

SVSASEVTST VYNTVSEGTH FLETIETPRP GKLFPKDVSS STPPSVTSKS RVSRLAGRKT 240 NESVSEPRKG FMYSRNTNEN PQECPNASKL LTSHGMGIQV PLNATEFNYL CPAIINQIDA 300

RSCLIHTSEK KAEIPPKTYS LQIAWVGGFI AISIISFLSL LGVILVPLMN RVFFKFLLSP 360

LVALAVGTLS GDAFLHLLPH SHASHHHSHS HEEPAMEMKR GPLFSHLSSQ NIEESAYFDS 420

TWKGLTALGG LYFMFLVEHV LTLIKQFKDK KKKNQKKPEN DDDVEIKKQL SKYESQLSTN 480

EEKVDTDDRT EGYLRADSQE PSHFDSQQPA VLEEEEVMIA HAHPQEVYNE YVPRGCKNKC 540 HSHFHDTLGQ SDDLIHHHHD YHHILHHHHH QNHHPHSHSQ RYSREELKDA GVATLAWMVI 600

MGDGLHNFSD GLAIGAAFTE GLSSGLSTSV AVFCHELPHE LGDFAVLLKA GMTVKQAVLY 660

NALSAMLAYL GMATGIFIGH YAENVSMWIF ALTAGLFMYV ALVDMVPEML HNDASDHGCS 720 RWGYFFLQNA GMLLGFGIML LISIFEHKIV FRINF Seq ID NO: 416 DNA sequence

Nucleic Acid Accession ft: NM_015419.1 Coding sequence: 1..8487 1 11 21 31 41 51

I I I I I I

ATGCCCAAGC GCGCGCACTG GGGGGCCCTC TCCGTGGTGC TGATCCTGCT TTGGGGCCAT 60

CCGCGAGTGG CGCTGGCCTG CCCGCATCCT TGTGCCTGCT ACGTCCCCAG CGAGGTCCAC 120

TGCACGTTCC GATCCCTGGC TTCCGTGCCC GCTGGCATTG CTAGACACGT GGAAAGAATC 180

AATTTGGGGT TTAATAGCAT ACAGGCCCTG TCAGAAACCT CATTTGCAGG ACTGACCAAG 240

TTGGAGCTAC TTATGATTCA CGGCAATGAG ATCCCAAGCA TCCCCGATGG AGCTTTAAGA 300

GACCTCAGCT CTCTTCAGGT TTTCAAGTTC AGCTACAACA AGCTGAGAGT GATCACAGGA 360

CAGACCCTCC AGGGTCTCTC TAACTTAATG AGGCTGCACA TTGACCACAA CAAGATCGAG 420

TTTATCCACC CTCAAGCTTT CAACGGCTTA ACGTCTCTGA GGCTACTCCA TTTGGAAGGA 480

AATCTCCTCC ACCAGCTGCA CCCCAGCACC TTCTCCACGT TCACATTTTT GGATTATTTC 540

AGACTCTCCA CCATAAGGCA CCTCTACTTA GCAGAGAACA TGGTTAGAAC TCTTCCTGCC 600

AGCATGCTTC GGAACATGCC GCTTCTGGAG AATCTTTACT TGCAGGGAAA TCCGTGGACC 660

TGCGATTGTG AGATGAGATG GTTTTTGGAA TGGGATGCAA AATCCAGAGG AATTCTGAAG 720

TGTAAAAAGG ACAAAGCTTA TGAAGGCGGT CAGTTGTGTG CAATGTGCTT CAGTCCAAAG 780

AAGTTGTACA AACATGAGAT ACACAAGCTG AAGGACATGA CTTGTCTGAA GCCTTCAATA 840

GAGTCCCCTC TGAGACAGAA CAGGAGCAGG AGTATTGAGG AGGAGCAAGA ACAGGAAGAG 900

GATGGTGGCA GCCAGCTCAT CCTGGAGAAA TTCCAACTGC CCCAGTGGAG CATCTCTTTG 960

AATATGACCG ACGAGCACGG GAACATGGTG AACTTGGTCT GTGACATCAA GAAACCAATG 1020

GATGTGTACA AGATTCACTT GAACCAAACG GATCCTCCAG ATATTGACAT AAATGCAACA 1080

GTTGCCTTGG ACTTTGAGTG TCCAATGACC CGAGAAAACT ATGAAAAGCT ATGGAAATTG 1140

ATAGCATACT ACAGTGAAGT TCCCGTGAAG CTACACAGAG AGCTCATGCT CAGCAAAGAC 1200

CCCAGAGTCA GCTACCAGTA CAGGCAGGAT GCTGATGAGG AAGCTCTTTA CTACACAGGT 1260

GTGAGAGCCC AGATTCTTGC AGAACCAGAA TGGGTCATGC AGCCATCCAT AGATATCCAG 1320

CTGAACCGAC GTCAGAGTAC GGCCAAGAAG GTGCTACTTT CCTACTACAC CCAGTATTCT 1380

CAAACAATAT CCACCAAAGA TACAAGGCAG GCTCGGGGCA GAAGCTGGGT AATGATTGAG 1440

CCTAGTGGAG CTGTGCAAAG AGATCAGACT GTCCTGGAAG GGGGTCCATG CCAGTTGAGC 1500

TGCAACGTGA AAGCTTCTGA GAGTCCATCT ATCTTCTGGG TGCTTCCAGA TGGCTCCATC 1560

CTGAAAGCGC CCATGGATGA CCCAGACAGC AAGTTCTCCA TTCTCAGCAG TGGCTGGCTG 1620

AGGATCAAGT CCATGGAGCC ATCTGACTCA GGCTTGTACC AGTGCATTGC TCAAGTGAGG 1680

GATGAAATGG ACCGCATGGT ATATAGGGTA CTTGTGCAGT CTCCCTCCAC TCAGCCAGCC 1740

GAGAAAGACA CAGTGACAAT TGGCAAGAAC CCAGGGGAGT CGGTGACATT GCCTTGCAAT 1800

GCTTTAGCAA TACCCGAAGC CCACCTTAGC TGGATTCTTC CAAACAGAAG GATAATTAAT 1860

GATTTGGCTA ACACATCACA TGTATACATG TTGCCAAATG GAACTCTTTC CATCCCAAAG 1920

GTCCAAGTCA GTGATAGTGG TTACTACAGA TGTGTGGCTG TCAACCAGCA AGGGGCAGAC 1980

CATTTTACGG TGGGAATCAC AGTGACCAAG AAAGGGTCTG GCTTGCCATC CAAAAGAGGC 2040

AGACGCCCAG GTGCAAAGGC TCTTTCCAGA GTCAGAGAAG ACATCGTGGA GGATGAAGGG 2100

GGCTCGGGCA TGGGAGATGA AGAGAACACT TCAAGGAGAC TTCTGCATCC AAAGGACCAA 2160

GAGGTGTTCC TCAAAACAAA GGATGATGCC ATCAATGGAG ACAAGAAAGC CAAGAAAGGG 2220

AGAAGAAAGC TGAAACTCTG GAAGCATTCG GAAAAAGAAC CAGAGACCAA TGTTGCAGAA 2280

GGTCGCAGAG TGTTTGAATC TAGACGAAGG ATAAACATGG CAAACAAACA GATTAATCCG 2340

GAGCGCTGGG CTGATATTTT AGCCAAAGTC CGTGGGAAAA ATCTCCCTAA GGGCACAGAA 2400

GTACCCCCGT TGATTAAAAC CACAAGTCCT CCATCCTTGA GCCTAGAAGT CACACCACCT 2460

TTTCCTGCTG TTTCTCCCCC CTCAGCATCT CCTGTGCAGA CAGTAACCAG TGCTGAAGAA 2520

TCCTCAGCAG ATGTACCTCT ACTTGGTGAA GAAGAGCACG TTTTGGGTAC CATTTCCTCA 2580

GCCAGCATGG GGCTAGAACA CAACCACAAT GGAGTTATTC TTGTTGAACC TGAAGTAACA 2640

AGCACACCTC TGGAGGAAGT TGTTGATGAC CTTTCTGAGA AGACTGAGGA GATAACTTCC 2700

ACTGAAGGAG ACCTGAAGGG GACAGCAGCC CCTACACTTA TATCTGAGCC TTATGAACCA 2760

TCTCCTACTC TGCACACATT AGACACAGTC TATGAAAAGC CCACCCATGA AGAGACGGCA 2820

ACAGAGGGTT GGTCTGCAGC AGATGTTGGA TCGTCACCAG AGCCCACATC CAGTGAGTAT 2880

GAGCCTCCAT TGGATGCTGT CTCCTTGGCT GAGTCTGAGC CCATGCAATA CTTTGACCCA 2940

GATTTGGAGA CTAAGTCACA ACCAGATGAG GATAAGATGA AAGAAGACAC CTTTGCACAC 3000

CTTACTCCAA CCCCCACCAT CTGGGTTAAT GACTCCAGTA CATCACAGTT ATTTGAGGAT 3060

TCTACTATAG GGGAACCAGG TGTCCCAGGC CAATCACATC TACAAGGACT GACAGACAAC 3120

ATCCACCTTG TGAAAAGTAG TCTAAGCACT CAAGACACCT TACTGATTAA AAAGGGTATG 3180

AAAGAGATGT CTCAGACACT ACAGGGAGGA AATATGCTAG AGGGAGACCC CACACACTCC 3240

AGAAGTTCTG AGAGTGAGGG CCAAGAGAGC AAATCCATCA CTTTGCCTGA CTCCACACTG 3300

GGTATAATGA GCAGTATGTC TCCAGTTAAG AAGCCTGCGG AAACCACAGT TGGTACCCTC 3360

CTAGACAAAG ACACCACAAC AGTAACAACA ACACCAAGGC AAAAAGTTGC TCCGTCATCC 3420

ACCATGAGCA CTCACCCTTC TCGAAGGAGA CCCAACGGGA GAAGGAGATT ACGCCCCAAC 3480

AAATTCCGCC ACCGGCACAA GCAAACCCCA CCCACAACTT TTGCCCCATC AGAGACTTTT 3540

TCTACTCAAC CAACTCAAGC ACCTGACATT AAGATTTCAA GTCAAGTGGA GAGTTCTCTG 3600

GTTCCTACAG CTTGGGTGGA TAACACAGTT AATACCCCCA AACAGTTGGA AATGGAGAAG 3660

AATGCAGAAC CCACATCCAA GGGAACACCA CGGAGAAAAC ACGGGAAGAG GCCAAACAAA 3720

CATCGATATA CCCCTTCTAC AGTGAGCTCA AGAGCGTCCG GATCCAAGCC CAGCCCTTCT 3780

CCAGAAAATA AACATAGAAA CATTGTTACT CCCAGTTCAG AAACTATACT TTTGCCTAGA 3840

ACTGTTTCTC TGAAAACTGA GGGCCCTTAT GATTCCTTAG ATTACATGAC AACCACCAGA 3900

AAAATATATT CATCTTACCC TAAAGTCCAA GAGACACTTC CAGTCACATA TAAACCCACA 3960

TCAGATGGAA AAGAAATTAA GGATGATGTT GCCACAAATG TTGACAAACA TAAAAGTGAC 4020

ATTTTAGTCA CTGGTGAATC AATTACTAAT GCCATACCAA CTTCTCGCTC CTTGGTCTCC 4080

ACTATGGGAG AATTTAAGGA AGAATCCTCT CCTGTAGGCT TTCCAGGAAC TCCAACCTGG 4140

AATCCCTCAA GGACGGCCCA GCCTGGGAGG CTACAGACAG ACATACCTGT TACCACTTCT 4200

GGGGAAAATC TTACAGACCC TCCCCTTCTT AAAGAGCTTG AGGATGTGGA TTTCACTTCC 4260

GAGTTTTTGT CCTCTTTGAC AGTCTCCACA CCATTTCACC AGGAAGAAGC TGGTTCTTCC 4320

ACAACTCTCT CAAGCATAAA AGTGGAGGTG GCTTCAAGTC AGGCAGAAAC CACCACCCTT 4380

GATCAAGATC ATCTTGAAAC CACTGTGGCT ATTCTCCTTT CTGAAACTAG ACCACAGAAT 4440

CACACCCCTA CTGCTGCCCG GATGAAGGAG CCAGCATCCT CGTCCCCATC CACAATTCTC 4500

ATGTCTTTGG GACAAACCAC CACCACTAAG CCAGCACTTC CCAGTCCAAG AATATCTCAA 4560

GCATCTAGAG ATTCCAAGGA AAATGTTTTC TTGAATTATG TGGGGAATCC AGAAACAGAA 4620

GCAACCCCAG TCAACAATGA AGGAACACAG CATATGTCAG GGCCAAATGA ATTATCAACA 4680

CCCTCTTCCG ACCGGGATGC ATTTAACTTG TCTACAAAGC TGGAATTGGA AAAGCAAGTA 4740

TTTGGTAGTA GGAGTCTACC ACGTGGCCCA GATAGCCAAC GCCAGGATGG AAGAGTTCAT 4800

GCTTCTCATC AACTAACCAG AGTCCCTGCC AAACCCATCC TACCAACAGC AACAGTGAGG 4860

CTACCTGAAA TGTCCACACA AAGCGCTTCC AGATACTTTG TAACTTCCCA GTCACCTCGT 4920

CACTGGACCA ACAAACCGGA AATAACTACA TATCCTTCTG GGGCTTTGCC AGAGAACAAA 4980

CAGTTTACAA CTCCAAGATT ATCAAGTACA ACAATTCCTC TCCCATTGCA CATGTCCAAA 5040 CCCAGCATTC CTAGTAAGTT TACTGACCGA AGAACTGACC AATTCAATGG TTACTCCAAA 5100

GTGTTTGGAA ATAACAACAT CCCTGAGGCA AGAAACCCAG TTGGAAAGCC TCCCAGTCCA 5160

AGAATTCCTC ATTATTCCAA TGGAAGACTC CCTTTCTTTA CCAACAAGAC TCTTTCTTTT 5220

CCACAGTTGG GAGTCACCCG GAGACCCCAG ATACCCACTT CTCCTGCCCC AGTAATGAGA 5280

GAGAGAAAAG TTATTCCAGG TTCCTACAAC AGGATACATT CCCATAGCAC CTTCCATCTG 5340

GACTTTGGCC CTCCGGCACC TCCGTTGTTG CACACTCCGC AGACCACGGG ATCACCCTCA 5400

ACTAACTTAC AGAATATCCC TATGGTCTCT TCCACCCAGA GTTCTATCTC CTTTATAACA 5460

TCTTCTGTCC AGTCCTCAGG AAGCTTCCAC CAGAGCAGCT CAAAGTTCTT TGCAGGAGGA 5520

CCTCCTGCAT CCAAATTCTG GTCTCTTGGG GAAAAGCCCC AAATCCTCAC CAAGTCCCCA 5580

CAGACTGTGT CCGTCACCGC TGAGACAGAC ACTGTGTTCC CCTGTGAGGC AACAGGAAAA 5640

CCAAAGCCTT TCGTTACTTG GACAAAGGTT TCCACAGGAG CTCTTATGAC TCCGAATACC 5700

AGGATACAAC GGTTTGAGGT TCTCAAGAAC GGTACCTTAG TGATACGGAA GGTTCAAGTA 5760

CAAGATCGAG GCCAGTATAT GTGCACCGCC AGCAACCTGC ACGGCCTGGA CAGGATGGTG 5820

GTCTTGCTTT CGGTCACCGT GCAGCAACCT CAAATCCTAG CCTCCCACTA CCAGGACGTC 5880

ACTGTCTACC TGGGAGACAC CATTGCAATG GAGTGTCTGG CCAAAGGGAC CCCAGCCCCC 5940

CAAATTTCCT GGATCTTCCC TGACAGGAGG GTGTGGCAAA CTGTGTCCCC CGTGGAGAGC 6000

CGCATCACCC TGCACGAAAA CCGGACCCTT TCCATCAAGG AGGCGTCCTT CTCAGACAGA 6060

GGCGTCTATA AGTGCGTGGC CAGCAATGCA GCCGGGGCGG ACAGCCTGGC CATCCGCCTG 6120

CACGTGGCGG CACTGCCCCC CGTTATCCAC CAGGAGAAGC TGGAGAACAT CTCGCTGCCC 6180

CCGGGGCTCA GCATTCACAT TCACTGCACT GCCAAGGCTG CGCCCCTGCC CAGCGTGCGC 6240

TGGGTGCTCG GGGACGGTAC CCAGATCCGC CCCTCGCAGT TCCTCCACGG GAACTTGTTT 6300

GTTTTCCCCA ACGGGACGCT CTACATCCGC AACCTCGCGC CCAAGGACAG CGGGCGCTAT 6360

GAGTGCGTGG CCGCCAACCT GGTAGGCTCC GCGCGCAGGA CGGTGCAGCT GAACGTGCAG 6420

CGTGCAGCAG CCAACGCGCG CATCACGGGC ACCTCCCCGC GGAGGACGGA CGTCAGGTAC 6480

GGAGGAACCC TCAAGCTGGA CTGCAGCGCC TCGGGGGACC CCTGGCCGCG CATCCTCTGG 6540

AGGCTGCCGT CCAAGAGGAT GATCGACGCG CTCTTCAGTT TTGATAGCAG AATCAAGGTG 6600

TTTGCCAATG GGACCCTGGT GGTGAAATCA GTGACGGACA AAGATGCCGG AGATTACCTG 6660

TGCGTAGCTC GAAATAAGGT TGGTGATGAC TACGTGGTGC TCAAAGTGGA TGTGGTGATG 6720

AAACCGGCCA AGATTGAACA CAAGGAGGAG AACGACCACA AAGTCTTCTA CGGGGGTGAC 6780

CTGAAAGTGG ACTGTGTGGC CACCGGGCTT CCCAATCCCG AGATCTCCTG GAGCCTCCCA 6840

GACGGGAGTC TGGTGAACTC CTTCATGCAG TCGGATGACA GCGGTGGACG CACCAAGCGC 6900

TATGTCGTCT TCAACAATGG GACACTCTAC TTTAACGAAG TGGGGATGAG GGAGGAAGGA 6960

GACTACACCT GCTTTGCTGA AAATCAGGTC GGGAAGGACG AGATGAGAGT CAGAGTCAAG 7020

GTGGTGACAG CGCCCGCCAC CATCCGGAAC AAGACTTACT TGGCGGTTCA GGTGCCCTAT 7080 GGAGACGTGG TCACTGTAGC CTGTGAGGCC AAAGGAGAAC CCATGCCCAA GGTGACTTGG 7140

TTGTCCCCAA CCAACAAGGT GATCCCCACC TCCTCTGAGA AGTATCAGAT ATACCAAGAT 7200

GGCACTCTCC TTATTCAGAA AGCCCAGCGT TCTGACAGCG GCAACTACAC CTGCCTGGTC 7260

AGGAACAGCG CGGGAGAGGA TAGGAAGACG GTGTGGATTC ACGTCAACGT CCAGCCACCC 7320

AAGATCAACG GTAACCCCAA CCCCATCACC ACCGTGCGGG AGATAGCAGC CGGGGGCAGT 7380 CGGAAACTGA TTGACTGCAA AGCTGAAGGC ATCCCCACCC CGAGGGTGTT ATGGGCTTTT 7440

CCCGAGGGTG TGGTTCTGCC AGCTCCATAC TATGGAAACC GGATCACTGT CCATGGCAAC 7500

GGTTCCCTGG ACATCAGGAG TTTGAGGAAG AGCGACTCCG TCCAGCTGGT ATGCATGGCA 7560

CGCAACGAGG GAGGGGAGGC GAGGTTGATC GTGCAGCTCA CTGTCCTGGA GCCCATGGAG 7620

AAACCCATCT TCCACGACCC GATCAGCGAG AAGATCACGG CCATGGCGGG CCACACCATC 7680 AGCCTCAACT GCTCTGCCGC GGGGACCCCG ACACCCAGCC TGGTGTGGGT CCTTCCCAAT 7740

GGCACCGATC TGCAGAGTGG ACAGCAGCTG CAGCGCTTCT ACCACAAGGC TGACGGCATG 7800

CTACACATTA GCGGTCTCTC CTCGGTGGAC GCTGGGGCCT ACCGCTGCGT GGCCCGCAAT 7860

GCCGCTGGCC ACACGGAGAG GCTGGTCTCC CTGAAGGTGG GACTGAAGCC AGAAGCAAAC 7920

AAGCAGTATC ATAACCTGGT CAGCATCATC AATGGTGAGA CCCTGAAGCT CCCCTGCACC 7980

CCTCCCGGGG CTGGGCAGGG ACGTTTCTCC TGGACGCTCC CCAATGGCAT GCATCTGGAG 8040

GGCCCCCAAA CCCTGGGACG CGTTTCTCTT CTGGACAATG GCACCCTCAC GGTTCGTGAG 8100

GCCTCGGTGT TTGACAGGGG TACCTATGTA TGCAGGATGG AGACGGAGTA CGGCCCTTCG 8160

GTCACCAGCA TCCCCGTGAT TGTGATCGCC TATCCTCCCC GGATCACCAG CGAGCCCACC 8220

CCGGTCATCT ACACCCGGCC CGGGAACACC GTGAAACTGA ACTGCATGGC TATGGGGATT 8280

CCCAAAGCTG ACATCACGTG GGAGTTACCG GATAAGTCGC ATCTGAAGGC AGGGGTTCAG 8340

GCTCGTCTGT ATGGAAACAG ATTTCTTCAC CCCCAGGGAT CACTGACCAT CCAGCATGCC 8400

ACACAGAGAG ATGCCGGCTT CTACAAGTGC ATGGCAAAAA ACATTCTCGG CAGTGACTCC 8460

AAAACAACTT ACATCCACGT CTTCTGAAAT GTGGATTCCA GAATGATTGC TTAGGAACTG 8520

ACAACAAAGC GGGGTTTGTA AGGGAAGCCA GGTTGGGGAA TAGGAGCTCT TAAATAATGT 8580

GTCACAGTGC ATGGTGGCCT CTGGTGGGTT TCAAGTTGAG GTTGATCTTG ATCTACAATT 8640

GTTGGGAAAA GGAAGCAATG CAGACACGAG AAGGAGGGCT CAGCCTTGCT GAGACACTTT 8700

CTTTTGTGTT TACATCATGC CAGGGGCTTC ATTCAGGGTG TCTGTGCTCT GACTGCAATT 8760

TTTCTTCTTT TGCAAATGCC ACTCGACTGC CTTCATAAGC GTCCATAGGA TATCTGAGGA 8820

ACATTCATCA AAAATAAGCC ATAGACATGA ACAACACCTC ACTACCCCAT TGAAGACGCA 8880

TCACCTAGTT AACCTGCTGC AGTTTTTACA TGATAGACTT TGTTCCAGAT TGACAAGTCA 8940

TCTTTCAGTT ATTTCCTCTG TCACTTCAAA ACTCCAGCTT GCCCAATAAG GATTTAGAAC 9000

CAGAGTGACT GATATATATA TATATATTTT AATTCAGAGT TACATACATA CAGCTACCAT 9060

TTTATATGAA AAAAGAAAAA CATTTCTTCC TGGAACTCAC TTTTTATATA ATGTTTTATA 9120

TATATATTTT TTCCTTTCAA ATCAGACGAT GAGACTAGAA GGAGAAATAC TTTCTGTCTT 9180 ATTAAAATTA ATAAATTATT GGTCTTTACA AGACTTGGAT ACATTACAGC AGACATGGAA 9240

ATATAATTTT AAAAAATTTC TCTCCAACCT CCTTCAAATT CAGTCACCAC^• TGTTATATTA 9300

CCTTCTCCAG GAACCCTCCA GTGGGGAAGG CTGCGATATT AGATTTCCTT GTATGCAAAG 9360

TTTTTGTTGA AAGCTGTGCT CAGAGGAGGT GAGAGGAGAG GAAGGAGAAA ACTGCATCAT 9420

AACTTTACAG AATTGAATCT AGAGTCTTCC CCGAAAAGCC CAGAAACTTC TCTGCAGTAT 9480 CTGGCTTGTC CATCTGGTCT AAGGTGGCTG CTTCTTCCCC AGCCATGAGT CAGTTTGTGC 9540

CCATGAATAA TACACGACCT GTTATTTCCA TGACTGCTTT ACTGTATTTT TAAGGTCAAT 9600

ATACTGTACA TTTGATAATA AAATAATATT CTCCCAAAAA AAAAA

Seq ID NO: 417 Protein sequence Protein Accession ft: NP_056234.1

1 11 21 31 41 51

I I I I I I

MPKRAHWGAL S LILLWGH PRVALACPHP CACYVPSEVH CTFRSLASVP AGIARHVERI 60 NLGFNSIQAL SETSFAGLTK LELLMIHGNE IPSIPDGALR DLSSLQVFKF SYNKLRVITG 120

QTLQGLSNLM RLHIDHNKIE FIHPQAFNGL TSLRLLHLEG NLLHQLHPST FSTFTFLDYF 180

RLSTIRHLYL AENMVRTLPA SMLRNMPLLE NLYLQGNPWT CDCEMRWFLE WDAKSRGILK 240 CKKDKAYEGG QLCAMCFSPK KLYKHEIHKL KDMTCLKPSI ESPLRQNRSR SIEEEQEQEE 300

DGGSQLILEK FQLPQWSISL NMTDEHGNMV NLVCDIKKPM DVYKIHLNQT DPPDIDINAT 360

VALDFECPMT RENYEKLWKL IAYYSEVPVK LHRELMLSKD PRVSYQYRQD ADEEALYYTG 420

VRAQILAEPE WVMQPSIDIQ LNRRQSTAKK VLLSYYTQYS QTISTKDTRQ ARGRSWVMIE 480

PSGAVQRDQT VLEGGPCQLS CNVKASESPS IFWVLPDGSI LKAPMDDPDS KFSILSSGWL 540

RIKSMEPSDS GLYQCIAQVR DEMDRMVYRV LVQSPSTQPA EKDTVTIGKN PGESVTLPCN 600

ALAIPEAHLS WILPNRRIIN DLANTSHVYM LPNGTLSIPK VQVSDSGYYR CVAVNQQGAD 660

HFTVGITVTK KGSGLPSKRG RRPGAKALSR VREDIVEDEG GSGMGDEENT SRRLLHPKDQ 720

EVFLKTKDDA INGDKKAKKG RRKLKLWKHS EKEPETNVAE GRRVFESRRR INMANKQINP 780

ERWADILAKV RGKNLPKGTE VPPLIKTTSP PSLSLEVTPP FPAVSPPSAS PVQTVTSAEE 840

SSADVPLLGE EEHVLGTISS ASMGLEHNHN GVILVEPEVT STPLEE DD LSEKTEEITS 900

TEGDLKGTAA PTLISEPYEP SPTLHTLDTV YEKPTHEETA TEGWSAADVG SSPEPTSSEY 960

EPPLDAVSLA ESEPMQYFDP DLETKSQPDE DKMKEDTFAH LTPTPTIWVN DSSTSQLFED 1020

STIGEPGVPG QSHLQGLTDN IHLVKSSLST QDTLLIKKGM KEMSQTLQGG NMLEGDPTHS 1080

RSSESEGQES KSITLPDSTL GIMSSMSPVK KPAETTVGTL LDKDTTTVTT TPRQKVAPSS 1140

TMSTHPSRRR PNGRRRLRPN KFRHRHKQTP PTTFAPSETF STQPTQAPDI KISSJVESSL 1200

VPTAWVDNTV NTPKQLEMEK NAEPTSKGTP RRKHGKRPNK HRYTPSTVSS RASGSKPSPS 1260

PENKHRNIVT PSSETILLPR TVSLKTEGPY DSLDYMTTTR KIYSSYPKVQ ETLPVTYKPT 1320

SDGKEIKDDV ATNVDKHKSD ILVTGESITN AIPTSRSLVS TMGEFKEESS PVGFPGTPTW 1380

NPSRTAQPGR LQTDIPVTTS GENLTDPPLL KELEDVDFTS EFLSSLTVST PFHQEEAGSS 1440

TTLSSIKVEV ASSQAETTTL DQDHLETTVA ILLSETRPQN HTPTAARMKE PASSSPSTIL 1500

MSLGQTTTTK PALPSPRISQ ASRDSKENVF LNYVGNPETE ATPVNNEGTQ HMSGPNELST 1560

PSSDRDAFNL STKLELEKQV FGSRSLPRGP DSQRQDGRVH ASHQLTRVPA KPILPTATVR 1620

LPEMSTQSAS RYFVTSQSPR HWTNKPEITT YPSGALPENK QFTTPRLSST TIPLPLHMSK 1680

PSIPSKFTDR RTDQFNGYSK VFGNNNIPEA RNPVGKPPSP RIPHYSNGRL PFFTNKTLSF 1740

PQLGVTRRPQ IPTSPAPVMR ERKVIPGSYN RIHSHSTFHL DFGPPAPPLL HTPQTTGSPS 1800

TNLQNIPMVS STQSSISFIT SSVQSSGSFH QSSSKFFAGG PPASKFWSLG EKPQILTKSP 1860

QTVSVTAETD TVFPCEATGK PKPFVTWTKV STGALMTPNT RIQRFEVLKN GTLVIRKVQV 1920

QDRGQYMCTA SNLHGLDRMV VLLSVTVQQP QILASHYQDV TVYLGDTIAM ECLAKGTPAP 1980

QISWIFPDRR VWQTVSPVES RITLHENRTL SIKEASFSDR GVYKCVASNA AGADSLAIRL 2040

HVAALPPVIH QEKLENISLP PGLSIHIHCT AKAAPLPSVR WVLGDGTQIR PSQFLHGNLF 2100

VFPNGTLYIR NLAPKDSGRY ECVAANLVGS ARRTVQLNVQ RAAANARITG TSPRRTDVRY 2160

GGTLKLDCSA SGDPWPRILW RLPSKRMIDA LPSFDSRIKV FANGTLWKS VTDKDAGDYL 2220

CVARNKVGDD YWLKVDWM KPAKIEHKEE NDHKVFYGGD LKVDCVATGL PNPEISWSLP 2280

DGSLVNSFMQ SDDSGGRTKR YWFNNGTLY FNEVGMREEG DYTCFAENQV GKDEMRVRVK 2340

WTAPATIRN KTYLAVQVPY GDWTVACEA KGEPMPKVTW LSPTNKVIPT SSEKYQIYQD 2400

GTLLIQKAQR SDSGNYTCLV RNSAGEDRKT VWIHVNVQPP KINGNPNPIT TVREIAAGGS 2460

RKLIDCKAEG IPTPRVLWAF PEGWLPAPY YGNRITVHGN GSLDIRSLRK SDSVQLVCMA 2520

RNEGGEARLI VQLTVLEPME KPIFHDPISE KITAMAGHTI SLNCSAAGTP TPSLVWVLPN 2580

GTDLQSGQQL QRFYHKADGM LHISGLSSVD AGAYRCVARN AAGHTERLVS LKVGLKPEAN 2640

KQYHNLVSII NGETLKLPCT PPGAGQGRFS WTLPNGMHLE GPQTLGRVSL LDNGTLTVRE 2700

ASVFDRGTYV CRMETEYGPS VTSIPVIVIA YPPRITSEPT PVIYTRPGNT VKLNCMAMGI 2760

PKADITWELP DKSHLKAGVQ ARLYGNRFLH PQGSLTIQHA TQRDAGFYKC MAKNILGSDS 2820 KTTYIHVF

Seq ID NO: 418 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 1..5001

1 11 21 31 41 51

A ITGCCAGGCA CIAAAACTAAC CICGAACAGGC GICCCCAGCAG AICTACAGAGT GIATATTGAAG 60

ACCTCTCAAG AGGACGAATT GGATGTACCT GACGACATCA GCGTCCGGGT TATGTCATCT 120

CAGTCTGTGC TTGTGTCCTG GGTGGATCCT GTTCTGGAAA AACAGAAGAA AGTTGTTGCA 180

TCAAGACAGT ACACCGTGCG CTATCGAGAG AAGGGGGAAT TGGCCAGGTG GGATTATAAG 240

CAGATCGCTA ACAGGCGTGT GCTGATTGAG AACCTGATTC CAGACACTGT GTATGAATTT 300

GCAGTCCGTA TTTCACAGGG TGAAAGAGAT GGCAAATGGA GTACGTCAGT CTTCCAAAGA 360

ACACCAGAAT CTGCCCCTAC CACAGCTCCT GAAAACTTGA ACGTCTGGCC AGTCAATGGC 420

AAACCTACAG TTGTCGCTGC ATCTTGGGAT GCGCTACCAG AGACTGAGGG GAAAGTGAAA 480

GTCTGTCTGC TGGACACAGG ACTGTTTTCA GTTTCCTCCT TCCAACCATC TGCCAAATCA 540

TTTGAGAATA CATTCTTTCA TACGCCCCGG CTCTCAAACC ATTTGGAGCA AAGTCCCTCA 600

CCTATCCTGG AGACACTACT TCTGCCCTGG TGGATGGTCT GCAGCCTGGG GAACGCTATC 660

TTTTCAAAAT CCGGGCCACA AACAGGAGAG GCCTGGGACC TCACTCCAAA GCCTTCATTG 720

TCGCTATGCC AACAAGAATG CAGCTGTACC CAGAAGGATT TCAGTTGTCT AGCTTACCTG 780

ATCGATATCC AAACCAAACA AGTTAATAAA GATCCACAAC TGGAAGGGAG TGTTTTTGGA 840

CCATGTTTTC TTTTCTACTT CCTCACATTT ATGCTGGATA TTGGCGGCTT TTCCTTCATT 900

ATGTGCTATG AAGACCCANN TGTTTCTTCT TTGACAGGCA ATTCTTTAAA ATCTGTTGCA 960

GCCAGTAAGG CGGATGTTCA GCAGAACACG GAGGACAATG GGAAACCCGA AAAACCTGAG 1020

CCTTCCTCAC CTTCTCCCAG AGCTCCAGCT TCCTCCCAAC ACCCCTCTGT GCCTGCTTCT 1080

CCCCAAGGGA GAAATGCCAA GGACCTTCTT CTTGACTTGA AGAACAAAAT ATTGGCTAAT 1140

GGTGGGGCGC CCCGAAAACC CCAGCTTCGC GCCAAGAAGG CAGAGGAGCT GGATCTTCAG 1200

TCGACAGAAA TCACTGGGGA GGAGGAGCTG GGTTCCCGGG AGGACTCGCC CATGTCACCC 1260

TCAGACACCC AAGACCAGAA ACGGACCCTG AGGCCGCCAA GTAGACACGG CCACTCGGTG 1320

GTTGCTCCCG GCAGGACTGC AGTGAGGGCC CGGATGCCAG CGCTGCCCCG AAGGGAAGGC 1380

GTAGATAAGC CTGGCTTTTC CCTGGCCACG CAGCCCCGCC CAGGGGCGCC CCCCTCGGCT 1440

TCGGCCTCTC CTGCCCACCA CGCGTCCACC CAGGGCACCT CTCATCGTCC TTCCCTGCCT 1500

GCCAGCTTGA ATGACAACGA CTTGGTGGAC TCAGACGAAG ATGAGCGCGC TGTGGGCTCC 1560

CTCCACCCCA AGGGCGCCTT CGCCCAGCCC CGGCCAGCCC TGTCCCCCAG CCGCCAGTCC 1620

CCGTCCAGCG TTCTCCGCGA CAGAAGCTCT GTGCACCCCG GCGCAAAGCC AGCCTCGCCG 1680

GCGCGGAGGA CCCCCCATTC AGGGGCCGCA GAGGAAGATT CCAGTGCCTC AGCCCCACCC 1740

TCAAGACTTT CTCCACCCCA TGGGGGATCA TCTCGGCTGC TGCCCACCCA GCCACACCTG 1800

AGCTCTCCAC TTTCCAAGGG CGGGAAGGAT GGTGAGGACG CCCCAGCCAC CAACTCCAAT 1860

GCGCCATCAC GGTCCACCAT GTCCTCCTCC GTCTCTTCTC ATCTCTCGTC CAGGACGCAG 1920

GTCTCTGAGG GAGCGGAGGC TTCTGATGGT GAAAGCCACG CTGACGGCGA TAGGGAAGAC 1980

GGCGGAAGGC AGGCGGAGGC CACGGCCCAG ACGCTGCGGG CCCGGCCTGC CTCTGGACAC 2040

TTCCATTTGC TCAGACACAA ACCCTTTGCT GCCAACGGGA GGTCTCCAAG CAGGTTCAGC 2100

ATTGGGCGGG GACCTCGGCT GCAGCCCTCC AGCTCCCCAC AGTCGACTGT GCCCTCCCGA 2160 GCCCACCCCA GGGTTCCCTC TCACTCTGAT TCCCACCGTA AGCTTAGCTC AGGTATCCAT 2220

GGAGACGAGG AGGATGAGAA GCCGCTTCCT GCCACCGTTG TCAATGACCA CGTGCCTTCC 2280

TCCTCCAGGC AGCCCATCTC CCGGGGCTGG GAGGACTTAA GGAGAAGCCC GCAGAGAGGΒ 2340

GCCAGCCTGC ATCGGAAGGA ACCCATCCCA GAGAACCCCA AATCCACAGG GGCAGATACA 2400

CATCCTCAGG GCAAGTACTC CTCCCTGGCC TCCAAGGCTC AGGATGTTCA ACAGAGCACA 2460

GACGCGGACA CGGAGGGTCA TTCTCCCAAA GCACAGCCAG GGTCCACAGA CCGCCACGCG 2520

TCCCCTGCTC GTCCTCCCGC AGCACGGTCA CAGCAGCATC CCAGTGTTCC CAGAAGGATG 2580

ACACCCGGCC GGGCCCCAGA ACAGCAGCCC CCTCCTCCCG TCGCCACGTC CCAGCACCAC 2640

CCGGGACCCC AGAGCAGAGA CGCGGGTCGG TCACCTTCCC AGCCCAGGCT CTCACTGACC 2700

CAGGCCGGGC GGCCCCGCCC CACGTCGCAG GGCCGCTCCC ACTCCTCCTC GGACCCTTAC 2760

ACGGCGAGCT CCAGAGGGAT GCTCCCCACG GCCCTCCAGA ACCAGGACGA GGATGCCCAG 2820

GGCAGCTACG ACGACGACAG CACAGAAGTC GAGGCCCAGG ATGTGCGGGC CCCCGCGCAC 2880

GCCGCGCGCG CCAAGGAGGC AGCTGCGTCC CTTCCCAAGC ACCAGCAGGT GGAGTCTCCC 2940

ACAGGCGCAG GGGCAGGTGG CGACCACAGG TCCCAGCGCG GACATGCGGC CTCCCCCGCC 3000

AGGCCCAGCC GACCCGGCGG CCCCCAGTCC CGCGCCCGGG TCCCCAGCAG GGCAGCGCCG 3060

GGGAAGTCGG AGCCTCCTTC CAAGCGGCCC CTGTCCTCCA AGTCCCAGCA GTCGGTCTCA 3120

GCCGAGGACG AGGAGGAGGA GGACGCGGGG TTTTTTAAAG GCGGGAAAGA AGACCTTCTG 3180

TCTTCCTCTG TGCCAAAGTG GCCCTCTTCC TCCACTCCCA GGGGCGGCAA AGACGCCGAT 3240

GGGAGCCTCG CCAAGGAAGA GAGGGAGCCT GCCATCGCGC TTGCCCCTCG CGGAGGGAGC 3300

CTGGCTCCTG TGAAGCGACC TCTCCCCCCA CCTCCAGGCA GCTCCCCCAG GGCCTCCCAC 3360

GTCCCTTCCC GACCGCCGCC TCGCAGCGCT GCCACCGTGA GCCCCGTCGC GGGCACCCAC 3420

CCCTGGCCGC GGTACACCAC GCGCGCCCCV CCTGGCCACT TCTCCACCAC CCCGATGCTG 3480

TCCTTGCGCC AGAGGATGAT GCATGCCAGA TTCCGTAACC CTCTCTCCCG ACAGCCTGCC 3540

AGACCCTCTT ACAGACAAGG TTATAATGGC AGACCAAATG TAGAAGGGAA AGTCCTTCCT 3600

GGTAGTAATG GAAAACCGAA TGGACAGAGA ATTATCAATG GCCCTCAAGG AACAAAGTGG 3660

GTTGTGGACC TTGATCGTGG GTTAGTATTG AATGCAGAAG GAAGGTACCT CCAAGATTCA 3720

CATGGAAATC CTCTTCGGAT TAAACTAGGA GGAGATGGTC GAACCATTGT AGATCTGGAA 3780

GGGACCCCCG TGGTGAGTCC TGACGGCCTC CCACTCTTTG GGCAGGGGCG ACATGGCACA 3840

CCTCTGGCCA ATGCCCAAGA TAAGCCAATT TTGAGTCTTG GAGGAAAGCC GCTGGTGGGC 3900

TTGGAGGTCA TCAAAAAAAC CACCCATCCC CCTACCACTA CCATGCAGCC CACCACTACT 3960

ACGACGCCCC TGCCTACCAC TACAACCCCG AGGCCCACCA CTGCCACCAC CATGCAGCCC 4020

ACCACTACTA CGACGCCCCT GCCTACCACT ACACCGAGGC CCACCACTGC CACCACCCGC 4080

CGCACGACCA CCAGGCGTCC AACAACCACA GTCCGAACCA CTACGCGGAC AACCACCACC 4140

ACCACCCCCA AACCCACCAC TCCCATCCCC ACCTGTCCCC CTGGGACCTT GGAACGGCAC 4200

GACGATGATG GCAACCTGAT AATGAGCTCC AATGGGATCC CAGAGTGCTA CGCTGAAGAA 4260

GATGAGTTCT CAGGCTTGGA GACTGACACT GCAGTACCTA CGGAAGAGGC CTACGTTATA 4320

TATGATGAAG ATTATGAATT TGAGACGTCA AGGCCACCAA CCACCACTGA GCCTTCGACC 4380

ACTGCTACCA CACCGAGGGT GATCCCAGAG GAAGGCGCCA TCAGTTCCTT TCCTGAAGAA 4440

GAATTTGATC TGGCTGGAAG GAAACGATTT GTTGCTCCTT ACGTGACGTA CCTAAATAAA 4500

GACCCATCAG CCCCGTGCTC TCTGACTGAT GCACTGGATC ACTTCCAAGT GGACAGCCTG 4560

GATGAAATCA TCCCCAATGA CCTGAAGAAG AGTGATCTGC CTCCCCAGCA TGCTCCCCGC 4620

AACATCACCG TGGTGGCCGT GGAAGGTTGC CACTCATTTG TCATTGTGGA TTGGGACAAA 4680

GCCACCCCAG GAGATTTGGT CACAGGTTAT TTGGTTTACA GTGCATCCTA TGAAGATTTC 4740

ATCAGGAACA AGTTTTCCAC TCAAGCTTCA TCAGTAACTC ACTTGCCCAT TGAGAACCTA 4800

AAGCCCAACA CGAGGTATTA TTTTAAAGTG CAAGCACAAA ATCCTCATGG CTACGGACCT 4860

ATCAGCCCΓΓ CGGTCTCATT TGTCACCGAA TCAGATAATC CTCTGCTTGT TGTGAGGCCC 4920

CCAGGCGGTG AGCTATCTGG ATCCCATTCG CTTTCAAACA TGATCCCAGC TACACGGACT 4980

GCCATGGACG GCAATATGTG AAGCGCACGT GGTATCGAAA GTTCGTGGGA GTTGTTCTTT 5040

GTAATTCACT GAGGTATAAA ATCTACCTCA GTGACAACCT GAAAGATACA TTCTACAGCA 5100

TTGGAGACAG CTGGGGAAGA GGTGAAGACC ATTGCCAATT TGTGGATTCA CACCTTGATG 5160

GAAGAACAGG GCCTCAGTCC TATGTAGAAG CCCTCCCTAC TATTCAAGGC TACTATCGCC 5220

AGTATCGTCA GGAGCCTGTC AGGTTTGGGA ACATCGGCTT CGGAACCCCC TACTACTATG 5280

TGGGCTGGTA CGAGTGTGGG GTCTCCATCC CTGGAAAGTG GTAATCACAG GACCGTCATG 5340

CTGCAAGCTT GCCCTGCCCA GCCCCACCAA CTAAGTCGCA CTAGGGGCTG TGAGCAAAGA 5400

CAGCCAGCAT GCTCAGCCCC GCTGCCCTAG GTGCCAGGAA GGTCACAGAT GGACACTGGC 5460

CATTCTGGTC ATCTCAGTCT GGAACTCAGT CCCACTTCTT GGCCTGGACA ATGAACAGGA 5520

TTCAGTTTTG CTGTTAACTT TGCTTCTCTA CTTTTTTTTG TTTGTTTGTA ATAGCACATC 5580

CCAGAGACAT CAGAAACCAG CAACTGATTC AGTGTGATTT CCCAGACTTT TTAGGCATGA 5640

AATTCGGACA CTTCAGTATT TCCAGGAATA GCATATGCAC GCTGTTCTTG CTTCATGGAA 5700

^'TGCTACATGC TTTCTGTTTT TCTCATTTTG GATTTCTCCA AAACTAACTG AATTTAAGCT 5760

TCAGGTCCCT TTGTATGCAG TAGAAAGGAA TTATTAAAAA CACCAGCAAA GAAAATAAAT 5820

ATATCCTACT TGAAATTTAC TCTATGGACT TACCCACTGC TAGAATAAAT GTATCAAATC 5880

TTATTTGTAA ATTCTCAATT TTGATATATA TATGTATATA TGCATATACA TATCCACACT 5940

TGTCTGCAAG AATATTGATT AAAATTGCTA AATTTGTACT TGTTCACCAA AAAAAAAAAA 6000

AAAAAAA

Seq ID NO: 419 Protein sequence Protein Accession ft: Eos sequence

1 11 21 31 41 51

MPGTKLTRTG APADYRVILK TSQEDELDVP DDISVRVMSS QSVLVSWVDP VLEKQKKWA 60

SRQYTVRYRE KGELARWDYK QIANRRVLIE NLIPDTVYEF AVRISQGERD GKWSTSVFQR 120

TPESAPTTAP ENLNVWPVNG KPTWAASWD ALPETEGKVK VCLLDTGLFS VSSFQPSAKS 180 FQNTFFHTPR LSNHLEQSPS PILETLLLPW WMVCSLGNAI FSKSGPQTGE AWDLTPKPSL 240

SLCQQECSCT QKDFSCLAYL IDIQTKQVNK DPQLEGSVFG PCFLFYFLTF MLDIGGFSFI 300

MCYEDPVSSL TGNSLKSVAA SKADVQQNTE DNGKPEKPEP SSPSPRAPAS SQHPSVPASP 360

QGRNAKDLLL DLKNKILANG GAPRKPQLRA KKAEELDLQS TEITGEEELG SREDSPMSPS 420

DTQDQKRTLR PPSRHGHSW APGRTAVRAR MPALPRREGV DKPGFSLATQ PRPGAPPSAS 480 ASPAHHASTQ GTSHRPSLPA SLNDNDLVDS DEDERAVGSL HPKGAFAQPR PALSPSRQSP 540

SSVLRDRSSV HPGAKPASPA RRTPHSGAAE EDSSASAPPS RLSPPHGGSS RLLPTQPHLS 600

SPLSKGGKDG EDAPATNSNA PSRSTMSSSV SSHLSSRTQV SEGAEASDGE SHGDGDREDG 660

GRQAEATAQT LRARPASGHF HLLRHKPFAA NGRSPSRFSI GRGPRLQPSS SPQSTVPSRA 720

HPRVPSHSDS HPKLSSGIHG DEEDEKPLPA TWNDHVPSS SRQPISRGWE DLRRSPQRGA 780 SLHRKEPIPE NPKSTGADTH PQGKYSSLAS KAQDVQQSTD ADTEGHSPKA QPGSTDRHAS 840

PARPPAARSQ QHPSVPRRMT PGRAPEQQPP PPVATSQHHP GPQSRDAGRS PSQPRLSLTQ 900

AGRPRPTSQG RSHSSSDPYT ASSRGMLPTA LQNQDEDAQG SYDDDSTEVE AQDVRAPAHA 960 ARAKEAAASL PKHQQVBSPT GAGAGGDHRS QRGHAASPAR PSRPGGPQSR ARVPSRAAPG 1020

KSEPPSKRPL SSKSQQSVSA EDEEEEDAGF FKGGKEDLLS SSVPKWPSSS TPRGGKDADG 1080

SLAKEEREPA IALAPRGGSL APVKRPLPPP PGSSPRASHV PSRPPPRSAA TVSPVAGTHP 1140

WPRYTTRAPP GHFSTTPMLS LRQRMMHARF RNPLSRQPAR PSYRQGYNGR PNVEGKVLPG 1200

5 SNGKPNGQRI INGPQGTKWV VDLDRGLVLN AEGRYLQDSH GNPLRIKLGG DGRTIVDLEG 1260

TPWSPDGLP LFGQGRHGTP LANAQDKPIL SLGGKPLVGL EVIKKTTHPP TTTMQPTTTT 1320

TPLPTTTTPR PTTATTMQPT TTTTPLPTTT PRPTTATTRR TTTRRPTTTV RTTTRTTTTT 1380

TPKPTTPIPT CPPGTLERHD DDGNLIMSSN GIPECYAEED EFSGLETDTA VPTEEAYVIY 1440

DEDYEFETSR PPTTTEPSTT ATTPRVIPEE GAISSFPEEE FDLAGRKRFV APYVTYLNKD 1500

10 PSAPCSLTDA LDHFQVDSLD EIIPNDLKKS DLPPQHAPRN ITWAVEGCH SFVIVDWDKA 1560

TPGDLVTGYL VYSASYEDFI RNKFSTQASS VTHLPIENLK PNTRYYFKVQ AQNPHGYGPI 1620 SPSVSFVTES DNPLLWRPP GGELSGSHSL SNMIPATRTA MDGNM

Seq ID NO: 420 DNA sequence 15 Nucleic Acid Accession ft: NM_022743 Coding sequence: 128..1237

1 11 21 31 41 51

_9n I I I I I I

Δ\J GTGGATTTTA GAGATACCTC CCCTCCTTCT GCTCAGCTGC CTTGCAGTAA TTAAACTCTT 60

TCTCTGCTGC AACACCCCTA CTGTTCTCCG TGTATTGGCT TTTCTGGGCA GCAGGAAGGA 120

AAAGCTGATG CGATGCTCTC AGTGCCGCGT CGCCAAATAC TGTAGTGCTA AGTGTCAGAA 180

AAAAGCTTGG CCAGACCACA AGCGGGAATG CAAATGCCTT AAAAGCTGCA AACCCAGATA 240

TCCTCCAGAC TCCGTTCGAC TTCTTGGCAG AGTTGTCTTC AAACTTATGG ATGGAGCACC 300

25 TTCAGAATCA GAGAAGCTTT ACTCATTTTA TGATCTGGAG TCAAATATTA ACAAACTGAC . 360

TGAAGATAAG AAAGAGGGCC TCAGGCAACT CGTAATGACA TTTCAACATT TCATGAGAGA 420

AGAAATACAG GATGCCTCTC AGCTGCCACC TGCCTTTGAC CTTTTTGAAG CCTTTGCAAA 480

AGTGATCTGC AACTCTTTCA CCATCTGTAA TGCGGAGATG CAGGAAGTTG GTGTTGGCCT 540

ATATCCCAGT ATCTCTTTGC TCAATCACAG CTGTGACCCC AACTGTTCGA TTGTGTTCAA 600

30 TGGGCCCCAC CTCTTACTGC GAGCAGTCCG AGACATCGAG GTGGGAGAGG AGCTCACCAT 660

CTGCTACCTG GATATGCTGA TGAGCAGTGA GGAGCGCCGG AAGCAGCTGA GGGACCAGTA 720

CTGCTTTGAA TGTGACTGTT TCCGTTGCCA AACCCAGGAC AAGGATGCTG ATATGCTAAC 780

TGGTGATGAG CAAGTATGGA AGGAAGTTCA AGAATCCCTG AAAAAAATTG AAGAACTGAA 840

GGCACACTGG AAGTGGGAGC AGGTTCTGGC CATGTGCCAG GCGATCATAA GCAGCAATTC 900

35 TGAACGGCTT CCCGATATCA ACATCTACCA GCTGAAGGTG CTCGACTGCG CCATGGATGC 960

CTGCATCAAC CTCGGCCTGT TGGAGGAAGC CTTGTTCTAT GGTACTCGGA CCATGGAGCC 1020

ATACAGGATT TTTTTCCCAG GAAGCCATCC CGTCAGAGGG GTTCAAGTGA TGAAAGTTGG 1080

CAAACTGCAG CTACATCAAG GCATGTTTCC CCAAGCAATG AAGAATCTGA GACTGGCTTT 1140

TGATATTATG AGAGTGACAC ATGGCAGAGA ACACAGCCTG ATTGAAGATT TGATTCTACT 1200

40 TTTAGAAGAA TGCGACGCCA ACATCAGAGC ATCCTAAGGG AACGCAGTCA GAGGGAAATA 1260

CGGCGTGTGT CTTTGTTGAA TGCCTTATTG AGGTCACACA CTCTATGCTT TGTTAGCTGT 1320

GTGAACCTCT CTTATTGGAA ATTCTGTTCC ^'GTGTTTGTGT AGGTAAATAA AGGCAGACAT 1380

GGTTTGCAAA CCACAAGAAT CATTAGTTGT AGAGAAGCAC GATTATAATA AATTCAAAAC 1440

ATTTGGTTGA GGATGCCAAA AAAAAAAAAA AAAAAAA

45

Seq ID NO: 421 Protein sequence Protein Accession ft: NP_073580

1 11 21 31 41 51

50 i i i i i i

MRCSQCRVAK YCSAKCQKKA WPDHKRECKC LKSCKPRYPP DSVRLLGRW FKLMDGAPSE 60

SEKLYSFYDL ESNINKLTED KKEGLRQLVM TFQHFMREEI QDASQLPPAF DLFEAFAKVI 120

CNSFTICNAE MQEVGVGLYP SISLLNHSCD PNCSIVFNGP HLLLRAVRDI EVGEELTICY 180

LDMLMTSEER RKQLRDQYCF ECDCFRCQTQ DKDADMLTGD EQVWKEVQES LKKIEELKAH 240

55 WKWEQVLAMC QAIISSNSER LPDINIYQLK VLDCAMDACI NLGLLEEALF YGTRTMEPYR 300

IFFPGSHPVR GVQVMKVGKL QLHQGMFPQA MKNLRLAFDI MRVTHGREHS LIEDLILLLE 360 ECDANIRAS

Seq ID NO: 422 DNA sequence

60 Nucleic Acid Accession ft: NM_003014.2

Coding sequence: 238..648

1 11 21 31 41 51 5 I I I I I I

GGCGGGTTCG CGCCCCGAAG GCTGAGAGCT GGCGCTGCTC GTGCCCTGTG TGCCAGACGG 60

CGGAGCTCCG CGGCCGGACC CCGCGGCCCC GCTTTGCTGC CGACTGGAGT TTGGGGGAAG 120

AAACTCTCCT GCGCCCCAGA AGATTTCTTC CTCGGCGAAG GGACAGCGAA AGATGAGGGT 180

GGCAGGAAGA GAAGGCGCTT TCTGTCTGCC GGGGTCGCAG CGCGAGAGGG CAGTGCCATG 240

TTCCTCTCCA TCCTAGTGGC GCTGTGCCTG TGGCTGCACC TGGCGCTGGG CGTGCGCGGC 300 0 GCGCCCTGCG AGGCGGTGCG CATCCCTATG TGCCGGCACA TGCCCTGGAA CATCACGCGG 360

ATGCCCAACC ACCTGCACCA CAGCACGCAG GAGAACGCCA TCCTGGCCAT CGAGCAGTAC 420

GAGGAGCTGG TGGACGTGAA CTGCAGCGCC GTGCTGCGCT TCTTCTTCTG TGCCATGTAC 480

GCGCCCATTT GCACCCTGGA GTTCCTGCAC GACCCTATCA AGCCGTGCAA GTCGGTGTGC 540

CAACGCGCGC GCGACGACTG CGAGCCCCTC ATGAAGATGT ACAACCACAG CTGGCCCGAA 600 5 AGCCTGGCCT GCGACGAGCT GCCTGTCTAT GACCGTGGCG TGTGCATTTC GCCTGAAGCC 660

ATCGTCACGG ACCTCCCGGA GGATGTTAAG TGGATAGACA TCACACCAGA CATGATGGTA 720

CAGGAAAGGC CTCTTGATGT TGACTGTAAA CGCCTAAGCC CCGATCGGTG CAAGTGTAAA 780

AAGGTGAAGC CAACTTTGGC AACGTATCTC AGCAAAAACT ACAGCTATGT TATTCATGCC 840

AAAATAAAAG CTGTGCAGAG GAGTGGCTGC AATGAGGTCA CAACGGTGGT GGATGTAAAA 900 0 GAGATCTTCA AGTCCTCATC ACCCATCCCT CGAACTCAAG TCCCGCTCAT TACAAATTCT 960

TCTTGCCAGT GTCCACACAT CCTGCCCCAT CAAGATGTTC TCATCATGTG TTACGAGTGG 1020

CGTTCAAGGA TGATGCTTCT TGAAAATTGC TTAGTTGAAA AATGGAGAGA TCAGCTTAGT 1080

AAAAGATCCA TACAGTGGGA AGAGAGGCTG CAGGAACAGC GGAGAACAGT TCAGGACAAG 1140

AAGAAAACAG CCGGGCGCAC CAGTCGTAGT AATCCCCCCA AACCAAAGGG AAAGCCTCCT 1200 5 GCTCCCAAAC CAGCCAGTCC CAAGAAGAAC ATTAAAACTA GGAGTGCCCA GAAGAGAACA 1260

.AACCCGAAAA GAGTGTGAGC TAACTAGTTT CCAAAGCGGA GACTTCCGAC TTCCTTACAG 1320

GATGAGGCTG GGCATTGCCT GGGACAGCCT ATGTAAGGCC ATGTGCCCCT TGCCCTAACA 1380 ACTCACTGCA GTGCTCTTCA TAGACACATC TTGCAGCATT TTTCTTAAGG CTATGCTTCA 1440 GTTTTTCTTT GTAAGCCATC ACAAGCCATA GTGGTAGGTT TGCCCTTTGG TACAGAAGGT 1500 GAGTTAAAGC TGGTGGAAAA GGCTTATTGC ATTGCATTCA GAGTAACCTG TGTGCATACT 1560 CTAGAAGAGT AGGGAAAATA ATGCTTGTTA CAATTCGACC TAATATGTGC ATTGTAAAAT 1620 AAATGCCATA TTTCAAACAA AACACGTAAT TTTTTTACAG TATGTTTTAT TACCTTTTGA 1680 TATCTGTTGT TGCAATGTTA GTGATGTTTT AAAATGTGAT GAAAATATAA TGTTTTTAAG 1740 AAGGAACAGT AGTGGAATGA ATGTTAAAAG ATCTTTATGT GTTTATGGTC TGCAGAAGGA 1800 TTTTTGTGAT GAAAGGGGAT TTTTTGAAAA ATTAGAGAAG TAGCATATGG AAAATTATAA 1860 TGTGTTTTTT TACCAATGAC TTCAGTTTCT GTTTTTAGCT AGAAACTTAA AAACAAAAAT 1920 AATAATAAAG AAAAATAAAT AAAAAGGAGA GGCAGACAAT GTCTGGATTC CTGTTTTTTG 1980 GTTACCTGAT TTCCATGATC ATGATGCTTC TTGTCAACAC CCTCTTAAGC AGCACCAGAA 2040 ACAGTGAGTT TGTCTGTACC ATTAGGAGTT AGGTACTAAT TAGTTGGCTA ATGCTCAAGT 2100 ATTTTATACC CACAAGAGAG GTATGTCACT CATCTTACTT CCCAGGACAT CCACCCTGAG 2160 AATAATTTGA CAAGCTTAAA AATGGCCTTC ATGTGAGTGC CAAATTTTGT TTTTCTTCAT 2220 TTAAATATTT TCTTTGCCTA AATACATGTG AGAGGAGTTA AATATAAATG TACAGAGAGG 2280 AAAGTTGAGT TCCACCTCTG AAATGAGAAT TACTTGACAG TTGGGATACT TTAATCAGAA 2340 AAAAAGAACT TATTTGCAGC ATTTTATCAA CAAATTTCAT AATTGTGGAC AATTGGAGGC 2400 ATTTATTTTA AAAAACAATT TTATTGGCCT TTTGCTAACA CAGTAAGCAT GTATTTTATA 2460 AGGCATTCAA TAAATGCACA ACGCCCAAAG GAAATAAAAT CCTATCTAAT CCTACTCTCC 2520 ACTACACAGA GGTAATCACT ATTAGTATTT TGGCATATTA TTCTCCAGGT GTTTGCTTAT 2580 GCACTTATAA AATGATTTGA ACAAATAAAA CTAGGAACCT GTATACATGT GTTTCATAAC 2640 CTGCCTCCTT TGCTTGGCCC TTTATTGAGA TAAGTTTTCC TGTCAAGAAA GCAGAAACCA 2700 TCTCATTTCT AACAGCTGTG TTATATTCCA TAGTATGCAT TACTCAACAA ACTGTTGTGC 2760 TATTGGATAC TTAGGTGGTT TCTTCACTGA CAATACTGAA TAAACATCTC ACCGGAATTC

Seq ID NO: 423 Protein sequence Protein Accession ft: NP 003005.1

11 21 31 41 51

I I

MFLSILVALC LWLHLALGVR G IAPCEAVRIP I

MCRHMPWNIT R IMPNHLHHST QENAILAIEQ 60 YEELVDVNCS AVLRFFFCAM YAPICTLEFL HDPIKPCKSV CQRARDDCEP LMKMYNHSWP 120 ESLACDELPV YDRGVCISPE AIVTDLPEDV KWIDITPDMM VQERPLDVDC KRLSPDRCKC 180 KKVKPTLATY LSKNYSYVIH AKIKAVQRSG CNEVTTWDV KEIFKSSSPI PRTQVPLITN 240 SSCQCPHILP HQDVLIMCYE WRSRMMLLEN CLVEKWRDQL SKRSIQWEER LQEQRRTVQD 300 KKKTAGRTSR SNPPKPKGKP PAPKPASPKK NIKTRSAQKR TNPKRV

Seq ID NO: 424 DNA sequence Nucleic Acid Accession ft: BC010423 Coding sequence: 248..1780

11 21 31 41 51

CACAGCGTGG GAAGCAGCTC TGGGGGAGCT CGGAGCTCCC GATCACGGCT TCTTGGGGGT 60 AGCTACGGCT GGGTGTGTAG AACGGGGCCG GGGCTGGGGC TGGGTCCCCT AGTGGAGACC 120 CAAGTGCGAG AGGCAAGAAC TCTGCAGCTT CCTGCCTTCT GGGTCAGTTC CTTATTCAAG 180 TCTGCAGCCG GCTCCCAGGG AGATCTCGGT GGAACTTCAG AAACGCTGGG CAGTCTGCCT 240 TTCAACCATG CCCCTGTCCC TGGGAGCCGA GATGTGGGGG CCTGAGGCCT GGCTGCTGCT 300 GCTGCTACTG CTGGCATCAT TTACAGGCCG GTGCCCCGCG GGTGAGCTGG AGACCTCAGA 360 CGTGGTAACT GTGGTGCTGG GCCAGGACGC AAAACTGCCC TGCTTCTACC GAGGGGACTC 420 CGGCGAGCAA GTGGGGCAAG TGGCATGGGC TCGGGTGGAC GCGGGCGAAG GCGCCCAGGA 480 ACTAGCGCTA CTGCACTCCA AATACGGGCT TCATGTGAGC CCGGCTTACG AGGGCCGCGT 540 GGAGCAGCCG CCGCCCCCAC GCAACCCCCT GGACGGCTCA GTGCTCCTGC GCAACGCAGT 600 GCAGGCGGAT GAGGGCGAGT ACGAGTGCCG GGTCAGCACC TTCCCCGCCG GCAGCTTCCA 660 GGCGCGGCTG CGGCTCCGAG TGCTGGTGCC TCCCCTGCCC TCACTGAATC CTGGTCCAGC 720 ACTAGAAGAG GGCCAGGGCC TGACCCTGGC AGCCTCCTGC ACAGCTGAGG GCAGCCCAGC 780 CCCCAGCGTG ACCTGGGACA CGGAGGTCAA AGGCACAACG TCCAGCCGTT CCTTCAAGCA 840 CTCCCGCTCT GCTGCCGTCA CCTCAGAGTT CCACTTGGTG CCTAGCCGCA GCATGAATGG 900 GCAGCCACTG ACTTGTGTGG TGTCCCATCC TGGCCTGCTC CAGGACCAAA GGATCACCCA 960 CATCCTCCAC GTGTCCTTCC TTGCTGAGGC CTCΪGTGAGG GGCCTTGAAG ACCAAAATCT 1020 GTGGCACATT GGCAGAGAAG GAGCTATGCT CAAGTGCCTG AGTGAAGGGC AGCCCCCTCC 1080 CTCATACAAC TGGACACGGC TGGATGGGCC TCTGCCCAGT GGGGTACGAG TGGATGGGGA 1140 CACTTTGGGC TTTCCCCCAC TGACCACTGA GCACAGCGGC ATCTACGTCT GCCATGTCAG 1200 CAATGAGTTC TCCTCAAGGG ATTCTCAGGT CACTGTGGAT GTTCTTGACC CCCAGGAAGA 1260 CΓCTGGGAAG CAGGTGGACC TAGTGTCAGC CTCGGTGGTG GTGGTGGGTG TGATCGCCGC 1320 ACTCTTGTTC TGCCTTCTGG TGGTGGTGGT GGTGCTCATG TCCCGATACC ATCGGCGCAA 1380 GGCCCAGCAG ATGACCCAGA AATATGAGGA GGAGCTGACC CTGACCAGGG AGAACTCCAT 1440 CCGGAGGCTG CATTCCCATC ACACGGACCC CAGGAGCCAG CCGGAGGAGA GTGTAGGGCT 1500 GAGAGCCGAG GGCCACCCTG ATAGTCTCAA GGACAACAGT AGCTGCTCTG TGATGAGTGA 1560 AGAGCCCGAG GGCCGCAGTT ACTCCACGCT GACCACGGTG AGGGAGATAG AAACACAGAC 1620^* TGAACTGCTG TCTCCAGGCT CTGGGCGGGC CGAGGAGGAG GAAGATCAGG ATGAAGGCAT 1680 CAAACAGGCC ATGAACCATT TTGTTCAGGA GAATGGGACC CTACGGGCCA AGCCCACGGG 1740 CAATGGCATC TACATCAATG GGCGGGGACA CCTGGTCTGA CCCAGGCCTG CCTCCCTTCC 1800 CTAGGCCTGG CTCCTTCTGT TGACATGGGA GATTTTAGCT CATCTTGGGG GCCTCCTTAA 1860 ACACCCCCAT TTCTTGCGGA AGATGCTCCC CATCCCACTG ACTGCTTGAC CTTTACCTCC 1920 AACCCTTCTG TTCATCGGGA GGGCTCCACC AATTGAGTCT CTCCCACCAT GCATGCAGGT 1980 CACTGTGTGT GTGCATGTGT GCCTGTGTGA GTGTTGACTG ACTGTGTGTG TGTGGAGGGG 2040 TGACTGTCCG TGGAGGGGTG ACTGTGTCCG TGGTGTGTAT TATGCTGTCA TATCAGAGTC 2100 AAGTGAACTG TGGTGTATGT GCCACGGGAT TTGAGTGGTT GCGTGGGCAA CACTGTCAGG 2160 GTTTGGCGTG TGTGTCATGT GGCTGTGTGT GACCTCTGCC TGAAAAAGCA GGTATTTTCT 2220 CAGACCCCAG AGCAGTATTA ATGATGCAGA GGTTGOAGGA GAGAGGTGGA GACTGTGGCT 2280 CAGACCCAGG TGTGCGGGCA TAGCTGGAGC TGGAATCTGC CTCCGGTGTG AGGGAACCTG 2340 TCTCCTACCA CTTCGGAGCC ATGGGGGCAA GTGTGAAGCA GCCAGTCCCT GGGTCAGCCA 2400 GAGGCTTGAA CTGTTACAGA AGCCCTCTGC CCTCTGGTGG CCTCTGGGCC TGCTGCATGT 2460 ACATATTTTC TGTAAATATA CATGCGCCGG GAGCTTCTTG CAGGAATACT GCTCCGAATC 2520 ACTTTTAATT TTTTTCTTTT TTTTTTCTTG CCCTTTCCAT TAGTTGTATT TTTTATTTAT 2580 TTTTATTTTT ATTTTTTTTT AGAGTTTGAG TCCAGCCTGG ACGATATAGC CAGACCCTGT 2640 CTGTAAAAAA ACCAAAACCC AAAAAAAAAA AAAAAAAAAA

Seq ID NO: 425 Protein sequence Protein Accession ft: AAH10423

1 11 21 31 41 51

I I I I I I

MPLSLGAEMW GPEAWLLLLL LLASFTGRCP AGELETSD TWLGQDAKL PCFYRGDSGE 60

QVGQVAWARV DAGEGAQELA LLHSKYGLHV SPAYEGRVEQ PPPPRNPLDG SVLLRNAVQA 120

DEGEYECRVS TFPAGSFQAR LRLRVLVPPL PSLNPGPALE EGQGLTLAAS CTAEGSPAPS 180

VTWDTEVKGT TSSRSFKHSR SAAVTSEFHL VPSRSMNGQP LTCWSHPGL LQDQRITHIL 240

HVSFLAEASV RGLEDQNLWH IGREGAMLKC LSEGQPPPSY NWTRLDGPLP SGVRVDGDTL 300

GFPPLTTEHS GIYVCHVSNE FSSRDSQVTV DVLDPQEDSG KQVDLVSASV VGVIAALL 360

FCLLVWWL MSRYHRRKAQ QMTQKYEEEL TLTRENSIRR LHSHHTDPRS QPEESVGLRA 420

EGHPDSLKDN SSCSVMSEEP EGRSYSTLTT VREIETQTEL LSPGSGRAEE EEDQDEGIKQ 480

AMNHFVQENG TLRAKPTGNG IYINGRGHLV

Seq ID NO: 426 DNA sequence Nucleic Acid Accession ft: NM_003474.2 Coding sequence: 37..3036

1 11 21 31 41 51

I I I I I I

CACTAACGCT CTTCCTAGTC CCCGGGCCAA CTCGGACAGT TTGCTCATTT ATTGCAACGG 60

TCAAGGCTGG CTTGTGCCAG AACGGCGCGC GCGCGACGCA CGCACACACA CGGGGGGAAA 120

CTTTTTTAAA AATGAAAGGC TAGAAGAGCT CAGCGGCGGC GCGGGCCGTG CGCGAGGGCT 180

CCGGAGCTGA CTCGCCGAGG CAGGAAATCC CTCCGGTCGC GACGCCCGGC CCCGCTCGGC 240

GCCCGCGTGG GATGGTGCAG CGCTCGCCGC CGGGCCCGAG AGCTGCTGCA CTGAAGGCCG 300

GCGACGATGG CAGCGCGCCC GCTGCCCGTG TCCCCCGCCC GCGCCCTCCT GCTCGCCCTG 360

GCCGGTGCTC TGCTCGCGCC CTGCGAGGCC CGAGGGGTGA GCTTATGGAA CGAAGGAAGA 420

GCTGATGAAG TTGTCAGTGC CTCTGTTCGG AGTGGGGACC TCTGGATCCC AGTGAAGAGC 480

TTCGACTCCA AGAATCATCC AGAAGTGCTG AATATTCGAC TACAACGGGA AAGCAAAGAA 540

CTGATCATAA ATCTGGAAAG AAATGAAGGT CTCATTGCCA GCAGTTTCAC GGAAACCCAC 600

TATCTGCAAG ACGGTACTGA TGTCTCCCTC GCTCGAAATT ACACGGTAAT TCTGGGTCAC 660

TGTTACTACC ATGGACATGT ACGGGGATAT TCTGATTCAG CAGTCAGTCT CAGCACGTGT 720

TCTGGTCTCA GGGGACTTAT TGTGTTTGAA AATGAAAGCT ATGTCTTAGA ACCAATGAAA 780

AGTGCAACCA ACAGATACAA ACTCTTCCCA GCGAAGAAGC TGAAAAGCGT CCGGGGATCA 840

TGTGGATCAC ATCACAACAC ACCAAACCTC GCTGCAAAGA ATGTGTTTCC ACCACCCTCT 900

CAGACATGGG CAAGAAGGCA TAAAAGAGAG ACCCTCAAGG CAACTAAGTA TGTGGAGCTG 960

GTGATCGTGG CAGACAACCG AGAGTTTCAG AGGCAAGGAA AAGATCTGGA AAAAGTTAAG 1020

CAGCGATTAA TAGAGATTGC TAATCACGTT GACAAGTTTT ACAGACCACT GAACATTCGG 1080

ATCGTGTTGG TAGGCGTGGA AGTGTGGAAT GACATGGACA AATGCTCTGT AAGTCAGGAC 1140

CCATTCACCA GCCTCCATGA ATTTCTGGAC TGGAGGAAGA TGAAGCTTCT ACCTCGCAAA 1200

TCCCATGACA ATGCGCAGCT TGTCAGTGGG GTTTATTTCC AAGGGACCAC CATCGGCATG 1260

GCCCCAATCA TGAGCATGTG CACGGCAGAC CAGTCTGGGG GAATTGTCAT GGACCATTCA 1320

GACAATCCCC TTGGTGCAGC CGTGACCCTG GCACATGAGC TGGGCCACAA TTTCGGGATG 1380

AATCATGACA CACTGGACAG GGGCTGTAGC TGTCAAATGG CGGTTGAGAA AGGAGGCTGC 1440

ATCATGAACG CTTCCACCGG GTACCCATTT CCCATGGTGT TCAGCAGTTG CAGCAGGAAG 1500

GACTTGGAGA CCAGCCTGGA GAAAGGAATG GGGGTGTGCC TGTTTAACCT GCCGGAAGTC 1560

AGGGAGTCTT TCGGGGGCCA GAAGTGTGGG AACAGATTTG TGGAAGAAGG AGAGGAGTGT 1620

GACTGTGGGG AGCCAGAGGA ATGTATGAAT CGCTGCTGCA ATGCCACCAC CTGTACCCTG 1680

AAGCCGGACG CTGTGTGCGC ACATGGGCTG TGCTGTGAAG ACTGCCAGCT GAAGCCTGCA 1740

GGAACAGCGT GCAGGGACTC CAGCAACTCC TGTGACCTCC CAGAGTTCTG CACAGGGGCC 1800

AGCCCTCACT GCCCAGCCAA CGTGTACCTG CACGATGGGC ACTCATGTCA GGATGTGGAC 1860

GGCTACTGCT ACAATGGCAT CTGCCAGACT CACGAGCAGC AGTGTGTCAC ACTCTGGGGA 1920

CCAGGTGCTA AACCTGCCCC TGGGATCTGC TTTGAGAGAG TCAATTCTGC AGGTGATCCT 1980

TATGGCAACT GTGGCAAAGT CTCGAAGAGT TCCTTTGCCA AATGCGAGAT GAGAGATGCT 2040

AAATGTGGAA AAATCCAGTG TCAAGGAGGT GCCAGCCGGC CAGTCATTGG TACCAATGCC 2100

GTTTCCATAG AAACAAACAT CCCCCTGCAG CAAGGAGGCC GGATTCTGTG CCGGGGGACC 2160

CACGTGTACT TGGGCGATGA CATGCCGGAC CCAGGGCTTG TGCTTGCAGG CACAAAGTGT 2220

GCAGATGGAA AAATCTGCCT GAATCGTCAA TGTCAAAATA TTAGTGTCTT TGGGGTTCAC 2280

GAGTGTGCAA TGCAGTGCCA CGGCAGAGGG GTGTGCAACA ACAGGAAGAA CTGCCACTGC 2340

GAGGCCCACT GGGCACCTCC CTTCTGTGAC AAGTTTGGCT TTGGAGGAAG CACAGACAGC 2400

GGCCCCATCC GGCAAGCAGA TAACCAAGGT TTAACCATAG GAATTCTGGT GACCATCCTG 2460

TGTCTTCTTG CTGCCGGATT TGTGGTTTAT CTCAAAAGGA AGACCTTGAT ACGACTGCTG 2520

TTTACAAATA AGAAGACCAC CATTGAAAAA CTAAGGTGTG TGCGCCCTTC CCGGCCACCC 2580

CGTGGCTTCC AACCCTGTCA GGCTCACCTC GGCCACCTTG GAAAAGGCCT GATGAGGAAG 2640

CCGCCAGATT CCTACCCACC GAAGGACAAT CCCAGGAGAT TGCTGCAGTG TCAGAATGTT 2700

GACATCAGCA GACCCCTCAA CGGCCTGAAT GTCCCTCAGC CCCAGTCAAC TCAGCGAGTG 2760

CTTCCTCCCC TCCACCGGGC CCCACGTGCA CCTAGCGTCC CTGCCAGACC CCTGCCAGCC 2820

AAGCCTGCAC TTAGGCAGGC CCAGGGGACC TGTAAGCCAA ACCCCCCTCA GAAGCCTCTG 2880

CCTGCAGATC CTCTGGCCAG AACAACTCGG CTCACTCATG CCTTGGCCAG GACCCCAGGA 2940

CAATGGGAGA CTGGGCTCCG CCTGGCACCC CTCAGACCTG CTCCACAATA TCCACACCAA 3000

GTGCCCAGAT CCACCCACAC CGCCTATATT AAGTGAGAAG CCGACACCTT TTTTCAACAG 3060

TGAAGACAGA AGTTTGCACT ATCTTTCAGC TCCAGTTGGA GTTTTTTGTA CCAACTTTTA 3120

GGATTTTTTT TAATGTTTAA AACATCATTA CTATAAGAAC TTTGAGCTAC TGCCGTCAGT 3180

GCTGTGCTGT GCTATGGTGC TCTGTCTACT TGCACAGGTA CTTGTAAATT ATTAATTTAT 3240

GCAGAATGTT GATTACAGTG CAGTGCGCTG TAGTAGGCAT TTTTACCATC ACTGAGTTTT 3300

CCATGGCAGG AAGGCTTGTT GTGCTTTTAG TATTTTAGTG AACTTGAAAT ATCCTGCTTG 3360

ATGGGATTCT GGACAGGATG TGTTTGCTTT CTGATCAAGG CCTTATTGGA AAGCAGTCCC 3420

CCAACTACCC CCAGCTGTGC TTATGGTACC AGATGCAGCT CAAGAGATCC CAAGTAGAAT 3480

CTCAGTTGAT TTTCTGGATT CCCCATCTCA GGCCAGAGCC AAGGGGCTTC AGGTCCAGGC 3540

TGTGTTTGGC TTTCAGGGAG GCCCTGTGCC CCTTGACAAC TGGCAGGCAG GCTCCCAGGG 3600

ACACCTGGGA GAAATCTGGC TTCTGGCCAG GAAGCTTTGG TGAGAACCTG GGTTGCAGAC 3660

AGGAATCTTA AGGTGTAGCC ACACCAGGAT AGAGACTGGA ACACTAGACA AGCCAGAACT 3720

TGACCCTGAG CTGACCAGCC GTGAGCATCT TTGGAAGGGG TCTGTAGTGT CACTCAAGGC 3780

GGTGCTTGAT AGAAATGCCA AGCACTTCTT TTTCTCGCTG TCCTTTCTAG AGCACTGCCA 3840 CCAGTAGGTT ATTTAGCTTG GGAAAGGTGG TGTTTCTGTA AGAAACCTAC TGCCCAGGCA 3900 CTGCAAACCG CCACCTCCCT ATACTGCTTG GAGCTGAGCA AATCACCACA AACTGTAATA 3960 CAATGATCCT GTATTCAGAC AGATGAGGAC TTTCCATGGG ACCACAACTA TTTTCAGATG 4020 TGAACCATTA ACCAGATCTA GTCAATCAAG TCTGTTTACT GCAAGGTTCA ACTTATTAAC 4080 AATTAGGCAG ACTCTTTATG CTTGCAAAAA CTACAACCAA TGGAATGTGA TGTTCATGGG 4140 TATAGTTCAT GTCTGCTATC ATTATTCGTA GATATTGGAC AAAGAACCTT CTCTATGGGG 4200 CATCCTCTTT TTCCAACTTG GCTGCAGGAA TCTTTAAAAG ATGCTTTTAA CAGAGTCTGA 4260 ACCTATTTCT TAAACACTTG CAACCTACCT GTTGAGCATC ACAGAATGTG ATAAGGAAAT 4320 CAACTTGCTT ATCAACTTCC TAAATATTAT GAGATGTGGC TTGGGCAGCA TCCCCTTGAA 4380 CTCTTCACTC TTCAAATGCC TGACTAGGGA GCCATGTTTC ACAAGGTCTT TAAAGTGACT 4440 AATGGCATGA GAAATACAAA AATACTCAGA TAAGGTAAAA TGCCATGATG CCTCTGTCTT 4500 CTGGACTGGT TTTCACATTA GAAGACAATT GACAACAGTT ACATAATTCA CTCTGAGTGT 4560 TTTATGAGAA AGCCTTCTTT TGGGGTCAAC AGTTTTCCTA TGCTTTGAAA CAGAAAAATA 4620 TGTACCAAGA ATCTTGGTTT GCCTTCCAGA AAACAAAACT GCATTTCACT TTCCCGGTGT 4680 TCCCCACTGT ATCTAGGCAA CATAGTATTC ATGACTATGG ATAAACTAAA CACGTGACAC 4740 AAACACACAC AAAAGGGAAC CCAGCTCTAA TACATTCCAA CTCGTATAGC ATGCATCTGT 4800 TTATTCTATA GTTATTAAGT TCTTTAAAAT GTAAAGCCAT GCTGGAAAAT AATACTGCTG 4860 AGATACATAC AGAATTACTG TAACTGATTA CACTTGGTAA TTGTACTAAA GCCAAACATA 4920 TATATACTAT TAAAAAGGTT TACAGAATTT TATGGTGCAT TACGTGGGCA TTGTCTTTTT 4980 AGATGCCCAA ATCCTTAGAT CTGGCATGTT AGCCCTTCCT CCAATTATAA GAGGATATGA 5040 ACCAAAAAAA AAAAAAAAAA AA

Seq ID NO: 427 Protein sequence Protein Accession ft: NP 003465

11 21 31 41 51

I I I I I

MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNEGRAD EWSASVRSG DLWIPVKSFD 60 SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL QDGTDVSLAR NYTVILGHCY 120 YHGHVRGYSD SAVSLSTCSG LRGLIVFENE SYVLEPMKSA TNRYKLFPAK KLKSVRGSCG 180 SHHNTPNLAA KNVFPPPSQT WARRHKRETL KATKYVELVI VADNREFQRQ GKDLEKVKQR 240 LIEIANHVDK FYRPLNIRIV LVGVEVWNDM DKCSVSQDPF TSLHEFLDWR KMKLLPRKSH 300 DNAQLVSGVY FQGTTIGMAP IMSMCTADQS GGIVMDHSDN PLGAAVTLAH ELGHNFGMNH 360 DTLDRGCSCQ MAVEKGGCIM NASTGYPFPM VFSSCSRKDL ETSLEKGMGV CLFNLPEVRE 420 SFGGQKCGNR FVEEGEECDC GEPEECMNRC CNATTCTLKP DAVCAHGLCC EDCQLKPAGT 480 ACRDSSNSCD LPEFCTGASP HCPANVYLHD GHSCQDVDGY CYNGICQTHE QQCVTLWGPG 540 AKPAPGICFE RVNSAGDPYG NCGKVSKSSF AKCEMRDAKC GKIQCQGGAS RPVIGTNAVS 600 IETNIPLQQG GRILCRGTHV YLGDDMPDPG LVLAGTKCAD GKICLNRQCQ NISVFGVHEC 660 AMQCHGRGVC NNRKNCHCEA HWAPPFCDKF GFGGSTDSGP IRQADNQGLT IGILVTILCL 720 LAAGFWYLK RKTLIRLLFT NKKTTIEKLR CVRPSRPPRG FQPCQAHLGH LGKGLMRKPP 780 DSYPPKDNPR RLLQCQNVDI SRPLNGLNVP QPQSTQRVLP PLHRAPRAPS VPARPLPAKP 840 ALRQAQGTCK PNPPQKPLPA DPLARTTRLT HALARTPGQW ETGLRLAPLR PAPQYPHQVP 900 RSTHTAYIK

Seq ID NO: 428 DNA sequence

Nucleic Acid Accession ft: NM_003714

Coding sequence: 135..1043

11 21 31 41 51

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GAGGAGGAGG GAAAAGGCGA GCAAAAAGGA AGAGTGGGAG GAGGAGGGGA AGCGGCGAAG 60 GAGGAAGAGG AGGAGGAGGA AGAGGGGAGC ACAAAGGATC CAGGTCTCCC GACGGGAGGT 120 TAATACCAAG AACCATGTGT GCCGAGCGGC TGGGCCAGTT CATGACCCTG GCTTTGGTGT 180 TGGCCACCTT TGACCCGGCG CGGGGGACCG ACGCCACCAA CCCACCCGAG GGTCCCCAAG 240 ACAGGAGCTC CCAGCAGAAA GGCCGCCTGT CCCTGCAGAA TACAGCGGAG ATCCAGCACT 300 GTTTGGTCAA CGCTGGCGAT GTGGGGTGTG GCGTGTTTGA ATGTTTCGAG AACAACTCTT 360 GTGAGATTCG GGGCTTACAT GGGATTTGCA TGACTTTTCT GCACAACGCT GGAAAATTTG 420 ATGCCCAGGG CAAGTCATTC ATCAAAGACG CCTTGAAATG TAAGGCCCAC GCTCTGCGGC 480 ACAGGTTCGG CTGCATAAGC CGGAAGTGCC CGGCCATCAG GGAAATGGTG TCCCAGTTGC 540 AGCGGGAATG CTACCTCAAG CACGACCTGT GCGCGGCTGC CCAGGAGAAC ACCCGGGTGA 600 TAGTGGAGAT GATCCATTTC AAGGACTTGC TGCTGCACGA ACCCTACGTG GACCTCGTGA 660 ACTTGCTGCT GACCTGTGGG GAGGAGGTGA AGGAGGCCAT CACCCACAGC GTGCAGGTTC 720 AGTGTGAGCA GAACTGGGGA AGCCTGTGCT CCATCTTGAG CTTCTGCACC TCGGCCATCC 780 AGAAGCCTCC CACGGCGCCC CCCGAGCGCC AGCCCCAGGT GGACAGAACC AAGCTCTCCA 840 GGGCCCACCA CGGGGAAGCA GGACATCACC TCCCAGAGCC CAGCAGTAGG GAGACTGGCC 900 GAGGTGCCAA GGGTGAGCGA GGTAGCAAGA GCCACCCAAA CGCCCATGCC CGAGGCAGAG 960 TCGGGGGCCT TGGGGCTCAG GGACCTTCCG GAAGCAGCGA GTGGGAAGAC GAACAGTCTG 1020 AGTATTCTGA TATCCGGAGG TGAAATGAAA GGCCTGGCCA CGAAATCTTT CCTCCACGCC 1080 GTCCATTTTC TTATCTATGG ACATTCCAAA ACATTTACCA TTAGAGAGGG GGGATGTCAC 1140 ACGCAGGATT CTGTGGGGAC TGTGGACTTC ATCGAGGTGT GTGTTCGCGG AACGGACAGG 1200 TGAGATGGAG ACCCCTGGGG CCGTGGGGTC TCAGGGGTGC CTGGTGAATT CTGCACTTAC 1260 ACGTACTCAA GGGAGCGCGC CCGCGTTATC CTCGTACCTT TGTCTTCTTT CCATCTGTGG 1320 AGTCAGTGGG TGTCGGCCGC TCTGTTGTGG GGGAGGTGAA CCAGGGAGGG GCAGGGCAAG 1380 GCAGGGCCCC CAGAGCTGGG CCACACAGTG GGTGCTGGGC CTCGCCCCGA AGCTTCTGGT 1440 GCAGCAGCCT CTGGTGCTGT CTCCGCGGAA GTCAGGGCGG CTGGATTCCA GGACAGGAGT 1500 GAATGTAAAA ATAAATATCG CTTAGAATGC AGGAGAAGGG TGGAGAGGAG GCAGGGGCCG 1560 AGGGGGTGCT TGGTGCCAAA CTGAAATTCA GTTTCTTGTG TGGGGCCTTG CGGTTCAGAG 1620 CTCTTGGCGA GGGTGGAGGG AGGAGTGTCA TTTCTATGTG TAATTTCTGA GCCATTGTAC 1680 TGTCTGGGCT GGGGGGGACA CTGTCCAAGG GAGTGGCCCC TATGAGTTTA TATTTTAACC 1740 ACTGCTTCAA ATCTCGATTT CACTTTTTTT ATTTATCCAG TTATATCTAC ATATCTGTCA 1800 TCTAAATAAA TGGCTTTCAA ACAAAGCAAC TGGGTCATTA AAACCAGCTC AAAGGGGGTT 1860 TAAAAAAAAA AAAACCAGCC CATCCTTTGA GGCTGATTTT TCTTTTTTTT AAGTTCTATT 1920 TTAAAAGCTA TCAAACAGCG ACATAGCCAT ACATCTGACT GCCTGACATG GACTCCTGCC 1980 CACTTGGGGG AAACCTTATA CCCAGAGGAA AATACACACC TGGGGAGTAC ATTTGACAAA 2040 TTTCCCTTAG GATTTCGTTA TCTCACCTTG ACCCTCAGCC AAGATTGGTA AAGCTGCGTC 2100 CTGGCGATTC CAGGAGACCC AGCTGGAAAC CTGGCTTCTC CATGTGAGGG GATGGGAAAG 216Q GAAAGAAGAG AATGAAGACT ACTTAGTAAT TCCCATCAGG AAATGCTGAC CTTTTACATA 2220 AAATCAAGGA GACTGCTGAA AATCTCTAAG GGACAGGATT TTCCAGATCC TAATTGGAAA 2280 TTTAGCAATA AGGAGAGGAG TCCAAGGGGA CAAATAAAGG CAGAGAGAGA GAGAGAGAGA 2340 GGGAGAGGAA GAAAAGAGAG AGAGAAAAGA GCCTCGTGCC

Seq ID NO: 429 Protein sequence Protein Accession ft: NP_003705

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MCAERLGQFM TLALVLATFD PARGTDATNP PEGPQDRSSQ QKGRLSLQNT AEIQHCLVNA 60

GDVGCGVFEC FENNSCEIRG LHGICMTFLH NAGKFDAQGK SFIKDALKCK AHALRHRFGC 120

ISRKCPAIRE MVSQLQRECY LKHDLCAAAQ ENTRVIVEMI HFKDLLLHEP YVDLVNLLLT 180

CGEEVKEAIT HSVQVQCEQN WGSLCSILSF CTSAIQKPPT APPERQPQVD RTKLSRAHHG 240

EAGHHLPEPS SRETGRGAKG ERGSKSHPNA HARGRVGGLG AQGPSGSSEW EDEQSEYSDI 300 RR

Seq ID NO: 430 DNA sequence

Nucleic Acid Accession ft: NM_005940

Coding sequence: 23..1489

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AAGCCCAGCA GCCCCGGGGC GGATGGCTCC GGCCGCCTGG CTCCGCAGCG CGGCCGCGCG 60

CGCCCTCCTG CCCCCGATGC TGCTGCTGCT GCTCCAGCCG CCGCCGCTGC TGGCCCGGGC 120 TCTGCCGCCG GACGTCCACC ACCTCCATGC CGAGAGGAGG GGGCCACAGC CCTGGCATGC 180

AGCCCTGCCC AGTAGCCCGG CACCTGCCCC TGCCACGCAG GAAGCCCCCC GGCCTGCCAG 240

CAGCCTCAGG CCTCCCCGCT GTGGCGTGCC CGACCCATCT GATGGGCTGA GTGCCCGCAA 300

CCGACAGAAG AGGTTCGTGC TTTCTGGCGG GCGCTGGGAG AAGACGGACC TGACCTACAG 360

GATCCTTCGG TTCCCATGGC AGTTGGTGCA GGAGCAGGTG CGGCAGACGA TGGCAGAGGC 420 CCTAAAGGTA TGGAGCGATG TGACGCCACT CACCTTTACT GAGGTGCACG AGGGCCGTGC 480

TGACATCATG ATCGACTTCG CCAGGTACTG GCATGGGGAC GACCTGCCGT TTGATGGGCC 540

TGGGGGCATC CTGGCCCATG CCTTCTTCCC CAAGACTCAC CGAGAAGGGG ATGTCCACTT 600

CGACTATGAT GAGACCTGGA CTATCGGGGA TGACCAGGGC ACAGACCTGC TGCAGGTGGC 660

AGCCCATGAA TTTGGCCACG TGCTGGGGCT GCAGCACACA ACAGCAGCCA AGGCCCTGAT 720 GTCCGCCTTC TACACCTTTC GCTACCCACT GAGTCTCAGC CCAGATGACT GCAGGGGCGT 780

TCAACACCTA TATGGCCAGC CCTGGCCCAC TGTCACCTCC AGGACCCCAG CCCTGGGCCC 840

CCAGGCTGGG ATAGACACCA ATGAGATTGC ACCGCTGGAG CCAGACGCCC CGCCAGATGC 900

CTGTGAGGCC TCCTTTGACG CGGTCTCCAC CATCCGAGGC GAGCTCTTTT TCTTCAAAGC 960

GGGCTTTGTG TGGCGCCTCC GTGGGGGCCA GCTGCAGCCC GGCTACCCAG CATTGGCCTC 1020 TCGCCACTGG CAGGGACTGC CCAGCCCTGT GGACGCTGCC TTCGAGGATG CCCAGGGCCA 1080

CATTTGGTTC TTCCAAGGTG CTCAGTACTG GGTGTACGAC GGTGAAAAGC CAGTCCTGGG 1140

CCCCGCACCC CTCACCGAGC TGGGCCTGGT GAGGTTCCCG GTCCATGCTG CCTTGGTCTG 1200

GGGTCCCGAG AAGAACAAGA TCTACTTCTT CCGAGGCAGG GACTACTGGC GTTTCCACCC 1260

CAGCACCCGG CGTGTAGACA GTCCCGTGCC CCGCAGGGCC ACTGACTGGA GAGGGGTGCC 1320 CTCTGAGATC GACGCTGCCT TCCAGGATGC TGATGGCTAT GCCTACTTCC TGCGCGGCCG 1380

CCTCTACTGG AAGTTTGACC CTGTGAAGGT GAAGGCTCTG GAAGGCTTCC CCCGTCTCGT 1440

GGGTCCTGAC TTCTTTGGCT GTGCCGAGCC TGCCAACACT TTCCTCTGAC CATGGCTTGG 1500

ATGCCCTCAG GGGTGCTGAC CCCTGCCAGG CCACGAATAT CAGGCTAGAG ACCCATGGCC 1560

ATCTTTGTGG CTGTGGGCAC CAGGCATGGG ACTGAGCCCA TGTCTCCTGC AGGGGGATGG 1620 GGTGGGGTAC AACCACCATG ACAACTGCCG GGAGGGCCAC GCAGGTCGTG GTCACCTGCC 1680

AGCGACTGTC TCAGACTGGG CAGGGAGGCT TTGGCATGAC TTAAGAGGAA GGGCAGTCTT 1740

GGGACCCGCT ATGCAGGTCC TGGCAAACCT GGCTGCCCTG TCTCATCCCT GTCCCTCAGG 1800

GTAGCACCAT GGCAGGACTG GGGGAACTGG AGTGTCCTTG CTGTATCCCT GTTGTGAGGT 1860

TCCTTCCAGG GGCTGGCACT GAAGCAAGGG TGCTGGGGCC CCATGGCCTT CAGCCCTGGC 1920 TGAGCAACTG GGCTGTAGGG CAGGGCCACT TCCTGAGGTC AGGTCTTGGT AGGTGCCTGC 1980

ATCTGTCTGC CTTCTGGCTG ACAATCCTGG AAATCTGTTC TCCAGAATCC AGGCCAAAAA 2040

GTTCACAGTC AAATGGGGAG GGGTATTCTT CATGCAGGAG ACCCCAGGCC CTGGAGGCTG 2100

CAACATACCT CAATCCTGTC CCAGGCCGGA TCCTCCTGAA GCCCTTTTCG CAGCACTGCT 2160

ATCCTCCAAA GCCATTGTAA ATGTGTGTAC AGTGTGTATA AACCTTCTTC TTCTTTTTTT 2220 TTTTTAAACT GAGGATTGTC ATTAAACACA GTTGTTTTCT

Seq ID NO: 431 Protein sequence Protein Accession ft: NP 005931

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MAPAAWLRSA AARALLPPML LLLLQPPPLL ARALPPDVHH LHAERRGPQP WHAALPSSPA 60

PAPATQEAPR PASSLRPPRC GVPDPSDGLS ARNRQKRFVL SGGRWEKTDL TYRILRFPWQ 120

LVQEQVRQTM AEALKVWSDV TPLTFTEVHE GRADIMIDFA RYWHGDDLPF DGPGGILAHA 180 FFPKTHREGD VHFDYDETWT IGDDQGTDLL QVAAHEFGHV LGLQHTTAAK ALMSAFYTFR 240

YPLSLSPDDC RGVQHLYGQP WPTVTSRTPA LGPQAGIDTN EIAPLEPDAP PDACEASFDA 300

VSTIRGELFF FKAGFVWRLR GGQLQPGYPA LASRHWQGLP SPVDAAFEDA QGHIWFFQGA 360

QYWVYDGEKP VLGPAPLTEL GLVRFPVHAA LVWGPEKNKI YFFRGRDYWR FHPSTRRVDS 420

PVPRRATDWR GVPSEIDAAF QDADGYAYFL RGRLYWKFDP VKVKALEGFP RLVGPDFFGC 480 AEPANTFL

Seq ID NO: 432 DNA sequence

Nucleic Acid Accession ft: NM_024022

Coding sequence: 202..1563

1 11 21 31 41 51

A ICCGGGCACC GIGACGGCTCG GIGTACTTTCG TITCTTAATTA GIGTCATGCCC GITGTGAGCCA 60

GGAAAGGGCT GTGTTTATGG GAAGCCAGTA ACACTGTGGC CTACTATCTC TTCCGTGGTG 120 CCATCTACAT TTTTGGGACT CGGGAATTAT GAGGTAGAGG TGGAGGCGGA GCCGGATGTC 180

AGAGGTCCTG AAATAGTCAC CATGGGGGAA AATGATCCGC CTGCTGTTGA AGCCCCCTTC 240

TCATTCCGAT CGCTTTTTGG CCTTGATGAT TTGAAAATAA GTCCTGTTGC ACCAGATGCA 300 GATGCTGTTG CTGCACAGAT CCTGTCACTG CTGCCATTGA AGTTTTTTCC AATCATCGTC 360

ATTGGGATCA TTGCATTGAT ATTAGCACTG GCCATTGGTC TGGGCATCCA CTTCGACTGC 420

TCAGGGAAGT ACAGATGTCG CTCATCCTTT AAGTGTATCG AGCTGATAGC TCGATGTGAC 480

GGAGTCTCGG ATTGCAAAGA CGGGGAGGAC GAGTACCGCT GTGTCCGGGT GGGTGGTCAG 540

AATGCCGTGC TCCAGGTGTT CACAGCTGCT TCGTGGAAGA CCATGTGCTC CGATGACTGG 600

AAGGGTCACT ACGCAAATGT TGCCTGTGCC CAACTGGGTT TCCCAAGCTA TGTGAGTTCA 660

GATAACCTCA GAGTGAGCTC GCTGGAGGGG CAGTTCCGGG AGGAGTTTGT GTCCATCGAT 720

CACCTCTTGC CAGATGACAA GGTGACTGCA TTACACCACT CAGTATATGT GAGGGAGGGA 780

TGTGCCTCTG GCCACGTGGT^ TACCTTGCAG TGCACAGCCT GTGGTCATAG AAGGGGCTAC 840

AGCTCACGCA TCGTGGGTGG' AAACATGTCC TTGCTCTCGC AGTGGCCCTG GCAGGCCAGC 900

CTTCAGTTCC AGGGCTACCA CCTGTGCGGG GGCTCTGTCA TCACGCCCCT GTGGATCATC 960

ACTGCTGCAC ACTGTGTTTA TGACTTGTAC CTCCCCAAGT CATGGACCAT CCAGGTGGGT 1020

CTAGTTTCCC TGTTGGACAA TCCAGCCCCA TCCCACTTGG TGGAGAAGAT TGTCTACCAC 1080

AGCAAGTACA AGCCAAAGAG GCTGGGCAAT GACATCGCCC TTATGAAGCT GGCCGGGCCA 1140

CTCACGTTCA ATGAAATGAT CCAGCCTGTG TGCCTGCCCA ACTCTGAAGA GAACTTCCCC 1200

GATGGAAAAG TGTGCTGGAC GTCAGGATGG GGGGCCACAG AGGATGGAGG TGACGCCTCC 1260

CCTGTCCTGA ACCACGCGGC CGTCCCTTTG ATTTCCAACA AGATCTGCAA CCACAGGGAC 1320

GTGTACGGTG GCATCATCTC CCCCTCCATG CTCTGCGCGG GCTACCTGAC GGGTGGCGTG 1380

GACAGCTGCC AGGGGGACAG CGGGGGGCCC CTGGTGTGTC AAGAGAGGAG GCTGTGGAAG 1440

TTAGTGGGAG CGACCAGCTT TGGCATCGGC TGCGCAGAGG TGAACAAGCC TGGGGTGTAC 1500

ACCCGTGTCA CCTCCTTCCT GGACTGGATC CACGAGCAGA TGGAGAGAGA CCTAAAAACC 1560

TGAAGAGGAA GGGGACAAGT AGCCACCTGA GTTCCTGAGG TGATGAAGAC AGCCCGATCC 1620

TCCCCTGGAC TCCCGTGTAG GAACCTGCAC ACGAGCAGAC ACCCTTGGAG CTCTGAGTTC 1680

CGGCACCAGT AGCAGGCCCG AAAGAGGCAC CCTTCCATCT GATTCCAGCA CAACCTTCAA 1740

GCTGCTTTTT GTTTTTTGTT TTTTTGAGGT GGAGTCTCGC TCTGTTGCCC AGGCTGGAGT 1800

GCAGTGGCGA AATCCCTGCT CACTGCAGCC TCCGCTTCCC TGGTTCAAGC GATTCTCTTG 1860

CCTCAGCTTC CCCAGTAGCT GGGACCACAG GTGCCCGCCA CCACACCCAA CTAATTTTTG 1920

TATTTTTAGT AGAGACAGGG TTTCACCATG TTGGCCAGGC TGCTCTCAAA CCCCTGACCT 1980

CAAATGATGT GCCTGCTTCA GCCTCCCACA GTGCTGGGAT TACAGGCATG GGCCACCACG 2040

CCTAGCCTCA CGCTCCTTTC TGATCTTCAC TAAGAACAAA AGAAGCAGCA ACTTGCAAGG 2100

GCGGCCTTTC CCACTGGTCC ATCTGGTTTT CTCTCCAGGG GTCTTGCAAA ATTCCTGACG 2160

AGATAAGCAG TTATGTGACC TCACGTGCAA AGCCACCAAC AGCCACTCAG AAAAGACGCA 2220

CCAGCCCAGA AGTGCAGAAC TGCAGTCACT GCACGTTTTC ATCTCTAGGG ACCAGAACCA 2280

AACCCACCCT TTCTACTTCC AAGACTTATT TTCACATGTG GGGAGGTTAA TCTAGGAATG 2340

ACTCGTTTAA GGCCTATTTT CATGATTTCT TTGTAGCATT TGGTGCTTGA CGTATTATTG 2400

TCCTTTGATT CCAAATAATA TGTTTCCTTC CCTCAAAAAA AAAAAAAAAA AAAAAAAAAA 2460 AAAAA

Seq ID NO: 433 Protein sequence Protein Accession ft: NP_076927

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MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP IIVIGIIALI 60 LALAIGLGIH FDCSGKYRCR SSFKCIELIA RCDGVSDCKD GEDEYRCVRV GGQNAVLQVF 120

TAASWKTMCS DDWKGHYANV ACAQLGFPSY VSSDNLRVSS LEGQFREEFV SIDHLLPDDK 180

VTALHHSVYV REGCASGHW TLQCTACGHR RGYSSRIVGG NMSLLSQWPW QASLQFQGYH 240

LCGGSVITPL WIITAAHCVY DLYLPKSWTI QVGLVSLLDN PAPSHLVEKI VYHSKYKPKR 300

LGNDIALMKL AGPLTFNEMI QPVCLPNSEE NFPDGKVCWT SGWGATEDGG DASPVLNHAA 360 VPLISNKICN HRDVYGGIIS PSMLCAGYLT GGVDSCQGDS GGPLVCQERR LWKLVGATSF 420 GIGCAEVNKP GVYTRVTSFL DWIHEQMERD LKT

Seq ID NO: 434 DNA sequence

Nucleic Acid Accession ft: NM_000493.2

Coding sequence: 97..2139

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CACCTTCTGC ACTGCTCATC TGGGCAGAGG AAGCTTCAGA AAGCTGCCAA GGCACCATCT 60

CCAGGAACTC CCAGCACGCA GAATCCATCT GAGAATATGC TGCCACAAAT ACCCTTTTTG 120

CTGCTAGTAT CCTTGAACTT GGTTCATGGA GTGTTTTACG CTGAACGATA CCAAATGCCC 180

ACAGGCATAA AAGGCCCACT ACCCAACACC AAGACACAGT TCTTCATTCC CTACACCATA 240

AAGAGTAAAG GTATAGCAGT AAGAGGAGAG CAAGGTACTC CTGGTCCACC AGGCCCTGCT 300

GGACCTCGAG GGCACCCAGG TCCTTCTGGA CCACCAGGAA AACCAGGCTA CGGAAGTCCT 360

GGACTCCAAG GAGAGCCAGG GTTGCCAGGA CCACCGGGAC CATCAGCTGT AGGGAAACCA 420

GGTGTGCCAG GACTCCCAGG AAAACCAGGA GAGAGAGGAC CATATGGACC AAAAGGAGAT 480

GTTGGACCAG CTGGCCTACC AGGACCCCGG GGCCCACCAG GACCACCTGG AATCCCTGGA 540

CCGGCTGGAA TTTCTGTGCC AGGAAAACCT GGACAACAGG GACCCACAGG AGCCCCAGGA 600

CCCAGGGGCT TTCCTGGAGA AAAGGGTGCA CCAGGAGTCC CTGGTATGAA TGGACAGAAA 660

GGGGAAATGG GATATGGTGC TCCTGGTCGT CCAGGTGAGA GGGGTCTTCC AGGCCCTCAG 720

GGTCCCACAG GACCATCTGG CCCTCCTGGA GTGGGAAAAA GAGGTGAAAA TGGGGTTCCA 780

GGACAGCCAG GCATCAAAGG TGATAGAGGT TTTCCGGGAG AAATGGGACC AATTGGCCCA 840

CCAGGTCCCC AAGGCCCTCC TGGGGAACGA GGGCCAGAAG GCATTGGAAA GCCAGGAGCT 900

GCTGGAGCCC CAGGCCAGCC AGGGATTCCA GGAACAAAAG GTCTCCCTGG GGCTCCAGGA 960

ATAGCTGGGC CCCCAGGGCC' TCCTGGCTTT GGGAAACCAG GCTTGCCAGG CCTGAAGGGA 1020

GAAAGAGGAC CTGCTGGCCT TCCTGGGGGT CCAGGTGCCA AAGGGGAACA AGGGCCAGCA 1080

GGTCTTCCTG GGAAGCCAGG TCTGACTGGA CCCCCTGGGA ATATGGGACC CCAAGGACCA 1140

AAAGGCATCC CGGGTAGCCA TGGTCTCCCA GGCCCTAAAG GTGAGACAGG GCCAGCTGGG 1200

CCTGCAGGAT ACCCTGGGGC TAAGGGTGAA AGGGGTTCCC CTGGGTCAGA TGGAAAACCA 1260

GGGTACCCAG GAAAACCAGG TCTCGATGGT CCTAAGGGTA ACCCAGGGTT ACCAGGTCCA 1320

AAAGGTGATC CTGGAGTTGG AGGACCTCCT GGTCTCCCAG GCCCTGTGGG CCCAGCAGGA 1380

GCAAAGGGAA TGCCCGGACA CAATGGAGAG GCTGGCCCAA GAGGTGCCCC TGGAATACCA 1440

GGTACTAGAG GCCCTATTGG GCCACCAGGC ATTCCAGGAT TCCCTGGGTC TAAAGGGGAT 1500

CCAGGAAGTC CCGGTCCTCC TGGCCCAGCT GGCATAGCAA CTAAGGGCCT CAATGGACCC 1560

ACCGGGCCAC CAGGGCCTCC AGGTCCAAGA GGCCACTCTG GAGAGCCTGG TCTTCCAGGG 1620

CCCCCTGGGC CTCCAGGCCC ACCAGGTCAA GCAGTCATGC CTGAGGGTTT TATAAAGGCA 1680

GGCCAAAGGC CCAGTCTTTC TGGGACCCCT CTTGTTAGTG CCAACCAGGG GGTAACAGGA 1740 ATGCCTGTGT CTGCTTTTAC TGTTATTCTC TCCAAAGCTT ACCCAGCAAT AGGAACTCCC 1800

ATACCATTTG ATAAAATTTT GTATAACAGG CAACAGCATT ATGACCCAAG GACTGGAATC 1860

TTTACTTGTC AGATACCAGG AATATACTAT TTTTCATACC ACGTGCATGT GAAAGGGACT 1920

CATGTTTGGG TAGGCCTGTA TAAGAATGGC ACCCCTGTAA TGTACACCTA TGATGAA AC 1980

ACCAAAGGCT ACCTGGATCA GGCTTCAGGG AGTGCCATCA TCGATCTCAC AGAAAATGAC 2040

CAGGTGTGGC TCCAGCTTCC CAATGCCGAG TCAAATGGCC TATACTCCTC TGAGTATGTC 2100

CACTCCTCTT TCTCAGGATT CCTAGTGGCT CCAATGTGAG TACACCCCAC AGAGCTAATC 2160

TAAATCTTGT GCTAGAAAAA GCATTCTCTA ACTCTACCCC ACCCTACAAA ATGCATATGG 2220

AGGTAGGCTG AAAAGAATGT AATTTTTATT TTCTGAAATA CAGATTTGAG CTATCAGACC 2280

10 AACAAACCTT CCCCCTGAAA AGTGAGCAGC AACGTAAAAA CGTATGTGAA GCCTCTCTTG 2340

AATTTCTAGT TAGCAATCTT AAGGCTCTTT AAGGTTTTCT CCAATATTAA AAAATATCAC 2400

CAAAGAAGTC CTGCTATGTT AAAAACAAAC AACAAAAAAC AAAGCAACAA AAAAAAAAAT 2460

TAAAAAAAAA AACAGAAATA GAGCTCTAAG TTATGTGAAA TTTGATTTGA GAAACTCGGC 2520

ATTTCCTTTT TAAAAAAGCC TGTTTCTAAC TATGAATATG AGAACTTCTA GGAAACATCC 2580

15 AGGAGGTATC ATATAACTTT GTAGAACTTA AATACTTGAA TATTCAAATT TAAAAGACAC 2640

TGTATCCCCT AAAATATTTC TGATGGTGCA CTACTCTGAG GCCTGTATGG CCCCTTTCAT 2700

CAATATCTAT TCAAATATAC AGGTGCATAT ATACTTGTTA AAGCTCTTAT ATAAAAAAGC 2760

CCCAAAATAT TGAAGTTCAT CTGAAATGCA AGGTGCTTTC ATCAATGAAC CTTTTCAAAA 2820

CTTTTCTATG ATTGCAGAGA AGCTTTTTAT ATACCCAGCA TAACTTGGAA ACAGGTATCT 2880

20 GACCTATTCT TATTTAGTTA ACACAAGTGT GATTAATTTG ATTTCTTTAA TTCCTTATTG 2940

AATCTTATGT GATATGATTT TCTGGATTTA CAGAACATTA GCACATGTAC CTTGTGCCTC 3000

CCATTCAAGT GAAGTTATAA TTTACACTGA GGGTTTCAAA ATTCGACTAG AAGTGGAGAT 3060

ATATTATTTA TTTATGCACT GTACTGTATT TTTATATTGC TGTTTAAAAC TTTTAAGCTG 3120

TGCCTCACTT ATTAAAGCAC AAAATGTTTT ACCTACTCCT TATTTACGAC ACAATAAAAT 3180

25 AACATCAATA GATTTTTAGG CTGAATTAAT TTGAAAGCAG CAATTTGCTG TTCTCAACCA 3240 TTCTTTCAAG GCTTTTCATT CGACACAATA AAATAACATC AATAG

Seq ID NO: 435 Protein sequence Protein Accession ft: NP_000484.2

30

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MLPQIPFLLL VSLNLVHGVF YAERYQMPTG IKGPLPNTKT QFFIPYTIKS KGIAVRGEQG 60

TPGPPGPAGP RGHPGPSGPP GKPGYGSPGL QGEPGLPGPP GPSAVGKPGV PGLPGKPGER 120

35 GPYGPKGDVG PAGLPGPRGP PGPPGIPGPA GISVPGKPGQ QGPTGAPGPR GFPGEKGAPG 180

VPGMNGQKGE MGYGAPGRPG ERGLPGPQGP TGPSGPPGVG KRGENGVPGQ PGIKGDRGFP 240

GEMGPIGPPG PQGPPGERGP EGIGKPGAAG APGQPGIPGT KGLPGAPGIA GPPGPPGFGK 300

PGLPGLKGER GPAGLPGGPG AKGEQGPAGL PGKPGLTGPP GNMGEQGPKG IPGSHGLPGP 360

KGETGPAGPA GYPGAKGERG SPGSDGKPGY PGKPGLDGPK GNPGLPGPKG DPGVGGPPGL 420

40 PGPVGPAGAK GMPGHNGEAG PRGAPGIPGT RGPIGPPGIP GFPGSKGDPG SPGPPGPAGI 480

ATKGLNGPTG PPGPPGPRGH SGEPGLPGPP GPPGPPGQAV MPEGFIKAGQ RPSLSGTPLV 540

SANQGVTGMP VSAFTVILSK AYPAIGTPIP FDKILYNRQQ HYDPRTGIFT CQIPGIYYFS 600

YHVHVKGTHV WVGLYKNGTP VMYTYDEYTK GYLDQASGSA IIDLTENDQV WLQLPNAESN 660 GLYSSEYVHS SFSGFLVAPM

45

Seq ID NO: 436 DNA sequence

Nucleic Acid Accession ft: XM_062811

Coding sequence: 1..888

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ATGTGGGGCG CTGGCCGCTC GTCCGTCTCC TCATCCTGGA ACGCCGCTTC GCTCCTGCAG 60

CTGCTGCTGG CTGCGCTGCT GGCGGCGGGG GCGAGGGCCA GCGGCGAGTA CTGCCACGGC 120

TGGCTGGACG CGCAGGGCGT CTGGCGCATC GGCTTCCAGT GTCCCGAGCG CTTCGACGGC 180

55 GGCGACGCCA CCATCTGCTG CGGCAGCTGC GCGTTGCGCT ACTGCTGCTC CAGCGCCGAG 240

GCGCGCCTGG ACCAGGGCGG CTGCGACAAT GACCGCCAGC AGGGCGCTGG CGAGCCTGGC 300

CGGGCGGACA AAGACGGCCC CGACGGCTCG GCAGTGCCCA TCTACGTGCC GTTCCTCATT 360

GTTGGCTCCG TGTTTGTCGC CTTTATCATC TTGGGGTCCC TGGTGGCAGC CTGTTGCTGC 420

- AGATGTCTCC GGCCTAAGCA GGATCCCCAG CAGAGCCGAG CCCCAGGGGG TAACCGCTTG 480

60 ATGGAGACCA TCCCCATGAT CCCCAGTGCC AGCACCTCCC GGGGGTCGTC CTCAGGCCAG 540

TCCAGCACAG CTGCCAGTTC CAGCTCCAGC GCCAACTCAG GGGCCCGGGC GCCCCCAACA 600

AGGTCACAGA CCAACTGTTG CTTGCCGGAA GGGACCATGA ACAACGTGTA TGTCAACATG 660

CCCACGAATT TCTCTGTGCT GAACTGTCAG CAGGCCACCC AGATTGTGCC ACATCAAGGG 720

CAGTATCTGC ATCCCCCATA CGTGGGGTAC ACGGTGCAGC ACGACTCTGT GCCCATGACA 780

65 GCTGTGCCAC CTTTCATGGA CGGCCTGCAG CCTGGCTACA GGCAGATTCA GTCCCCCTTC 840 CCTCACACCA ACAGTGAACA GAAGATGTAC CCAGCGGTGA CTGTATAA

Seq ID NO: 437 Protein sequence Protein Accession ft: XP 062811

70

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MWGARRSSVS SSWNAASLLQ LLLAALLAAG ARASGEYCHG WLDAQGVWRI GFQCPERFDG 60

GDATICCGSC ALRYCCSSAE ARLDQGGCDN DRQQGAGEPG RADKDGPDGS AVPIYVPFLI 120

75 VGSVFVAFII LGSLVAACCC RCLRPKQDPQ QSRAPGGNRL METIPMIPSA STSRGSSSRQ 180

SSTAASSSSS ANSGARAPPT RSQTNCCLPE GTMNNVYVNM PTNFSVLNCQ QATQIVPHQG 240

QYLHPPYVGY TVQHDSVPMT AVPPFMDGLQ PGYRQIQSPF PHTNSEQKMY PAVTV

Seq ID NO: 438 DNA sequence 80 Nucleic Acid Accession ft: NM_004004.1 Coding sequence: 1..681

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OJ ATGGATTGGG GCACGCTGCA GACGATCCTG GGGGGTGTGA ACAAACACTG CACCAGCATT 60

GGAAAGATCT GGCTCACCGT CCTCTTCATT TTTCGCATTA TGATCCTCGT TGTGGCTGCA 120

AAGGAGGTGT GGGGAGATGA GCAGGCCGAC TTTGTCTGCA ACACCCTGCA GCCAGGCTGC 180 AAGAACGTGT GCTACGATCA CTACTTCCCC ATCTCCCACA TCCGGCTATG GGCCCTGCAG 240

CTGATCTTCG TGTCCAGCCC AGCGCTCCTA GTGGCCATGC ACGTGGCCTA CCGGAGACAT 300

GAGAAGAAGA GGAAGTTCAT CAAGGGGGAG ATAAAGAGTG AATTTAAGGA CATCGAGGAG 360

ATCAAAACCC AGAAGGTCCG CATCGAAGGC TCCCTGTGGT GGACCTACAC AAGCAGCATC 420

TTCTTCCGGG TCATCTTCGA AGCCGCCTTC ATGTACGTCT TCTATGTCAT GTACGACGGC 480

TTCTCCATGC AGCGGCTGGT GAAGTGCAAC GCCTGGCCTT GTCCCAACAC TGTGGACTGC 540

TTTGTGTCCC GGCCCACGGA GAAGACTGTC TTCACAGTGT TCATGATTGC AGTGTCTGGA 600

ATTTGCATCC TGCTGAATGT CACTGAATTG TGTTATTTGC TAATTAGATA TTGTTCTGGG 660 AAGTCAAAAA AGCCAGTTTA A

10

Seq ID NO: 439 Protein sequence Protein Accession ft: NP 003995.1

, 1 11 21 31 41 51

15 i i i i i i

MDWGTLQTIL GGVNKHSTSI GKIWLTVLFI FRIMILWAA KEVWGDEQAD FVCNTLQPGC 60

KNVCYDHYFP ISHIRLWALQ LIFVSSPALL VAMHVAYRRH EKKRKFIKGE IKSEFKDIEE 120

IKTQKVRIEG SLWWTYTSSI FFRVIFEAAF MYVFYVMYDG FSMQRLVKCN AWPCPNTVDC 180 FVSRPTEKTV FTVFMIAVSG ICILLNVTEL CYLLIRYCSG KSKKPV

20

Seq ID NO: 440 DNA sequence

Nucleic Acid Accession ft: XM_061091.1

Coding sequence: 1..2481

25

1 11 21 31 41 51

I I I I I I

ATGCCAAATA CTTCAGGAAC AACCAGGATT GAAATTTGGC TTCTCCAAGA GCCGCCCGGG 60

CACCGAGCGC TGGTCGCCGC TCTCCTTCCG GTGAGTCCCA GCCCCGAGTT GGCTCTGGCG 120

30 CCCGGGTACC CGCCAGTGCC GGCTGCCGAT GACCGATTCA CGCTCCCGAT GATTGGAGGT 180

CAGATGCATG GTGAGAAGGT AGATCTCTGG AGCCTTGGTG TTCTTTGCTA TGAATTTTTA 240

GTTGGGAAGC CTCCTTTTGA GGCAAACGAA GTCCATGTAA GCAAAGAAAC CATCGGGAAG 300

ATTTCAGCTG CCAGCAAAAT GATGTGGTGC TCGGCTGCAG TGGACATCAT GTTTCTGTTA 360

GATGGGTCTA ACAGCGTCGG GAAAGGGAGC TTTGAAAGGT CCAAGCACTT TGCCATCACA 420

35 GTCTGTGACG GTCTGGACAT CAGCCCCGAG AGGGTCAGAG TGGGAGCATT CCAGTTCAGT 480

TCCACTCCTC ATCTGGAATT CCCCTTGGAT TCATTTTCAA CCCAACAGGA AGTGAAGGCA 540

AGAATCAAGA GGATGGTTTT CAAAGGAGGG CGCACGGAGA CGGAACTTGC TCTGAAATAC 600

CTTCTGCACA GAGGGTTGCC TGGAGGCAGA AATGCTTCTG TGCCCCAGAT CCTCATCATC 660

GTCACTGATG GGAAGTCCCA GGGGGATGTG GCAGTGCCAT CCAAGCAGCT GAAGGAAAGG 720

40 GGTGTCACTG TGTTTGCTGT GGGGGTCAGG TTTCCCAGGT GGGAGGAGCT GCATGCACTG 780

GCCAGCGAGC CTAGAGGGCA GCACGTGCTG TTGGCTGAGC AGGTGGAGGA TGCCACCAAC 840

GGCCTCTTCA GCACCCTCAG CAGCTCGGCC ATCTGCTCCA GCGCCACGCC AGCTGGGAGC 900

CCCGAGCTTG TCTTCATGGA GCGGTTAATG GGCATCTCTC TGATAGGCCC CTGTGACTCG 960

CAGCCCTGCC AGAATGGAGG CACATGTGTT CCAGAAGGAC TGGACGGCTA CCAGTGCCTC 1020

45 TGCCCGCTGG CCTTTGGAGG GGAGGCTAAC TGTGCCCTGA AGCTGAGCCT GGAATGCAGG 1080

GTCGACCTCC TCTTCCTGCT GGACAGCTCT GCGGGCACCA CTCTGGACGG CTTCCTGCGG 1140

GCCAAAGTCT TCGTGAAGCG GTTTGTGCGG GCCGTGCTGA GCGAGGACTC TCGGGCCCGA 1200

GTGGGTGTGG CCACATACAG CAGGGAGCTG CTGGTGGCGG TGCCTGTGGG GGAGTACCAG 1260

GATGTGCCTG ACCTGGTCTG GAGCCTCGAT GGCATTCCCT TCCGTGGTGG CCCCACCCTG 1320

50 ACGGGCAGTG CCTTGCGGCA GGCGGCAGAG CGTGGCTTCG GGAGCGCCAC CAGGACAGGC 1380

CAGGACCGGC CACGTAGAGT GGTGGTTTTG CTCACTGAGT CACACTCCGA GGATGAGGTT 1440

GCGGGCCCAG CGCGTCACGC AAGGGCGCGA GAGCTGCTCC TGCTGGGTGT AGGCAGTGAG 1500

GCCGTGCGGG CAGAGCTGGA GGAGATCACA GGCAGCCCAA AGCATGTGAT GGTCTACTCG 1560

GATCCTCAGG ATCTGTTCAA CCAAATCCCT GAGCTGCAGG GGAAGCTGTG CAGCCGGCAG 1620

55 CGGCCAGGGT GCCGGACACA AGCCCTGGAC CTCGTCTTCA TGTTGGACAC CTCTGCCTCA 1680

GTAGGGCCCG AGAATTTTGC TCAGATGCAG AGCTTTGTGA GAAGCTGTGC CCTCCAGTTT 1740

GAGGTGAACC CTGACGTGAC ACAGGTCGGC CTGGTGGTGT ATGGCAGCCA GGTGCAGACT 1800

GCCTTCGGGC TGGACACCAA ACCCACCCGG GCTGCGATGC TGCGGGCCAT TAGCCAGGCC 1860

CCCTACCTAG GTGGGGTGGG CTCAGCCGGC ACCGCCCTGC TGCACATCTA TGACAAAGTG 1920

60 ATGACCGTCC AGAGGGGTGC CCGGCCTGGT GTCCCCAAAG CTGTGCTGGT GCTCACAGGC 1980

GGGAGAGGCG CAGAGGATGC AGCCGTTCCT GCCCAGAAGC TGAGGAACAA TGGCATCTCT 2040

GTCTTGGTCG TGGGCGTGGG GCCTGTCCTA AGTGAGGGTC TGCGGAGGCT TGCAGGTCCC 2100

CGGGATTCCC TGATCCACGT GGCAGCTTAC GCCGACCTGC GGTACCACCA GGACGTGCTC 2160

ATTGAGTGGC TGTGTGGAGA AGCCAAGCAG CCAGTCAACC TCTGCAAACC CAGCCCGTGC 2220

65 ATGAATGAGG GCAGCTGCGT CCTGCAGAAT GGGAGCTACC GCTGCAAGTG TCGGGATGGC 2280

TGGGAGGGCC CCCACTGCGA GAACCGTGAG TGGAGCTCTT GCTCTGTATG TGTGAGCCAG 2340

GGATGGATTC TTGAGACGCC CCTGAGGCAC ATGGCTCCCG TGCAGGAGGG CAGCAGCCGT 2400

ACCCCTCCCA GCAACTACAG AGAAGGCCTG GGCACTGAAA TGGTGCCTAC CTTCTGGAAT 2460 GTCTGTGCCC CAGGTCCTTA G

70

Seq ID NO: 441 Protein sequence Protein Accession ft: XP 061091.1

__ 1 11 21 31 41 51

75 i i i i i i

MPNTSGTTRI EIWLLQEPPG HRALVAALLP VSPSPELALA PGYPPVPAAD DRFTLPMIGG 60

QMHGEKVDLW SLGVLCYEFL VGKPPFEANE VHVSKETIGK ISAASKMMWC SAAVDIMFLL 120

DGSNSVGKGS FERSKHFAIT VCDGLDISPE RVRVGAFQFS STPHLEFPLD SFSTQQEVKA 180

RIKRMVFKGG RTETELALKY LLHRGLPGGR NASVPQILII VTDGKSQGDV ALPSKQLKER 240

80 GVTVFAVGVR FPRWEELHAL ASEPRGQHVL LAEQVEDATN GLFSTLSSSA ICSSATPAGS 300

PELVFMERLM GISLIGPCDS QPCQNGGTCV PEGLDGYQCL CPLAFGGEAN CALKLSLECR 360

VDLLFLLDSS AGTTLDGFLR AKVFVKRFVR AVLSEDSRAR VGVATYSREL LVAVPVGEYQ 420

DVPDLVWSLD GIPFRGGPTL TGSALRQAAE RGFGSATRTG QDRPRRVWL LTESHSEDEV 480

AGPARHARAR ELLLLGVGSE AVRAELEEIT GSPKHVMVYS DPQDLFNQIP ELQGKLCSRQ 540

85 RPGCRTQALD LVFMLDTSAS VGPENFAQMQ SFVRSCALQF EVNPDVTQVG LWYGSQVQT 600

AFGLDTKPTR AAMLRAISQA PYLGGVGSAG TALLHIYDKV MTVQRGARPG VPKAVWLTG 660

GRGAEDAAVP AQKLRNNGIS VL GVGPVL SEGLRRLAGP RDSLIHVAAY ADLRYHQDVL 720 IEWLCGEAKQ PVNLCKPSPC MNEGSCVLQN GSYRCKCRDG WEGPHCENRE WSSCSVCVSQ 780 GWILETPLRH MAPVQEGSSR TPPSNYREGL GTEMVPTFWN VCAPGP

Seq ID NO: 442 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 1..2424

1 11 21 31 41 51

A ITGCCCCCTT TICCTGTTGCT GIGAGGCCGTC TIGTGTTTTCC TIGTTTTCCAG AIGTGCCCCCA 60

TCTCTCCCTC TCCAGGAAGT CCATGTAAGC AAAGAAACCA TCGGGAAGAT TTCAGCTGCC 120

AGCAAAATGA TGTGGTGCTC GGCTGCAGTG GACATCATGT TTCTGTTAGA TGGGTCTAAC 180

AGCGTCGGGA AAGGGAGCTT TGAAAGGTCC AAGCACTTTG CCATCACAGT CTGTGACGGT 240

CTGGACATCA GCCCCGAGAG GGTCAGAGTG GGAGCATTCC AGTTCAGTTC CACTCCTCAT 300

CTGGAATTCC CCTTGGATTC ATTTTCAACC CAACAGGAAG TGAAGGCAAG AATCAAGAGG 360

ATGGTTTTCA AAGGAGGGCG CACGGAGACG GAACTTGCTC TGAAATACCT TCTGCACAGA 420

GGGTTGCCTG GAGGCAGAAA TGCTTCTGTG CCCCAGATCC TCATCATCGT CACTGATGGG 480

AAGTCCCAGG GGGATGTGGC ACTGCCATCC AAGCAGCTGA AGGAAAGGGG TGTCACTGTG 540

TTTGCTGTGG GGGTCAGGTT TCCCAGGTGG GAGGAGCTGC ATGCACTGGC CAGCGAGCCT 600

AGAGGGCAGC ACGTGCTGTT GGCTGAGCAG GTGGAGGATG CCACCAACGG CCTCTTCAGC 660

ACCCTCAGCA GCTCGGCCAT CTGCTCCAGC GCCACGCCAG ACTGCAGGGT CGAGGCTCAC 720

CCCTGTGAGC ACAGGACGCT GGAGATGGTC CGGGAGTTCG CTGGCAATGC CCCATGCTGG 780

AGAGGATCGC GGCGGACCCT TGCGGTGCTG GCTGCACACT GTCCCTTCTA CAGCTGGAAG 840

AGAGTGTTCC TAACCCACCC TGCCACCTGC TACAGGACCA CCTGCCCAGG CCCCTGTGAC 900

TCGCAGCCCT GCCAGAATGG AGGCACATGT GTTCCAGAAG GACTGGACGG CTACCAGTGC 960

CTCTGCCCGC TGGCCTTTGG AGGGGAGGCT AACTGTGCCC TGAAGCTGAG CCTGGAATGC 1020

AGGGTCGACC TCCTCTTCCT GCTGGACAGC TCTGCGGGCA CCACTCTGGA CGGCTTCCTG 1080

CGGGCCAAAG TCTTCGTGAA GCGGTTTGTG CGGGCCGTGC TGAGCGAGGA CTCTCGGGCC 1140

CGAGTGGGTG TGGCCACATA CAGCAGGGAG CTGCTGGTGG CGGTGCCTGT GGGGGAGTAC 1200

CAGGATGTGC CTGACCTGGT CTGGAGCCTC GATGGCATTC CCTTCCGTGG TGGCCCCACC 1260

CTGACGGGCA GTGCCTTGCG GCAGGCGGCA GAGCGTGGCT TCGGGAGCGC CACCAGGACA 1320

GGCCAGGACC GGCCACGTAG AGTGGTGGTT TTGCTCACTG AGTCACACTC CGAGGATGAG 1380

GTTGCGGGCC CAGCGCGTCA CGCAAGGGCG CGAGAGCTGC TCCTGCTGGG TGTAGGCAGT 1440

GAGGCCGTGC GGGCAGAGCT GGAGGAGATC ACAGGCAGCC CAAAGCATGT GATGGTCTAC 1500

TCGGATCCTC AGGATCTGTT CAACCAAATC CCTGAGCTGC AGGGGAAGCT GTGCAGCCGG 1560

CAGCGGCCAG GGTGCCGGAC ACAAGCCCTG GACCTCGTCT TCATGTTGGA CACCTCTGCC 1620

TCAGTAGGGC CCGAGAATTT TGCTCAGATG CAGAGCTTTG TGAGAAGCTG TGCCCTCCAG 1680

TTTGAGGTGA ACCCTGACGT GACACAGGTC GGCCTGGTGG TGTATGGCAG CCAGGTGCAG 1740

ACTGCCTTCG GGCTGGACAC CAAACCCACC CGGGCTGCGA TGCTGCGGGC CATTAGCCAG 1800

GCCCCCTACC TAGGTGGGGT GGGCTCAGCC GGCACCGCCC TGCTGCACAT CTATGACAAA 1860

GTGATGACCG TCCAGAGGGG TGCCCGGCCT GGTGTCCCCA AAGCTGTGGT GGTGCTCACA 1920

GGCGGGAGAG GCGCAGAGGA TGCAGCCGTT CCTGCCCAGA AGCTGAGGAA CAATGGCATC 1980

TCTGTCTTGG TCGTGGGCGT GGGGCCTGTC CTAAGTGAGG GTCTGCGGAG GCTTGCAGGT 2040

CCCCGGGATT CCCTGATCCA CGTGGCAGCT TACGCCGACC TGCGGTACCA CCAGGACGTG 2100

CTCATTGAGT GGCTGTGTGG AGAAGCCAAG CAGCCAGTCA ACCTCTGCAA ACCCAGCCCG 2160

TGCATGAATG AGGGCAGCTG CGTCCTGCAG AATGGGAGCT ACCGCTGCAA GTGTCGGGAT 2220

GGCTGGGAGG GCCCCCACTG CGAGAACCGT GAGTGGAGCT CTTGCTCTGT ATGTGTGAGC 2280

CAGGGATGGA TTCTTGAGAC GCCCCTGAGG CACATGGCTC CCGTGCAGGA GGGCAGCAGC 2340

CGTACCCCTC CCAGCAACTA CAGAGAAGGC CTGGGCACTG AAATGGTGCC TACCTTCTGG 2400 AATGTCTGTG CCCCAGGTCC TTAG

Seq ID NO: 443 Protein sequence Protein Accession ft: Eos sequence

1 11 21 31 41 51

M IPPFLLLEAV CIVFLFSRVPP SILPLQEVHVS KIETIGKISAA SIKMMWCSAAV DIIMFLLDGSN 60

SVGKGSFERS KHFAITVCDG LDISPERVRV GAFQFSSTPH LEFPLDSFST QQEVKARIKR 120

MVFKGGRTET ELALKYLLHR GLPGGRNASV PQILIIVTDG KSQGDVALPS KQLKERGVTV 180

FAVGVRFPRW EELHALASEP RGQHVLLAEQ VEDATNGLFS TLSSSAICSS ATPDCRVEAH 240

PCEHRTLEMV REFAGNAPCW RGSRRTLAVL AAHCPFYSWK RVFLTHPATC YRTTCPGPCD 300

SQPCQNGGTC VPEGLDGYQC LCPLAFGGEA NCALKLSLEC RVDLLFLLDS SAGTTLDGFL 360

RAKVFVKRFV RAVLSEDSRA RVGVATYSRE LLVAVPVGEY QDVPDLVWSL DGIPFRGGPT 420

LTGSALRQAA ERGFGSATRT GQDRPRR V LLTESHSEDE VAGPARHARA RELLLLGVGS 480

EAVRAELEEI TGSPKHVMVY SDPQDLFNQI PELQGKLCSR QRPGCRTQAL DLVFMLDTSA 540

SVGPENFAQM QSFVRSCALQ FEVNPDVTQV GL YGSQVQ TAFGLDTKPT RAAMLRAISQ 600

APYLGGVGSA GTALLHIYDK VMTVQRGARP GVPKA WLT GGRGAEDAAV PAQKLRNNGI 660

SVLWGVGPV LSEGLRRLAG PRDSLIHVAA YADLRYHQDV LIEWLCGEAK QPVNLCKPSP 720

CMNEGSCVLQ NGSYRCKCRD GWEGPHCENR EWSSCSVCVS QGWILETPLR HMAPVQEGSS 780 RTPPSNYREG LGTEMVPTFW NVCAPGP

Seq ID NO: 444 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 89..2356

1 11 21 31 41 51

I I I I I I

GCCCCCTGGC CCGAGCCGCG CCCGGGTCTG TGAGTAGAGC CGCCCGGGCA CCGAGCGCTG 60

GTCGCCGCTC TCCTTCCGTT ATATCAACAT GCCCCCTTTC CTGTTGCTGG AAGCCGTCTG 120

TGTTTTCCTG TTTTCCAGAG TGCCCCCATC TCTCCCTCTC CAGGAAGTCC ATGTAAGCAA 180

AGAAACCATC GGGAAGATTT CAGCTGCCAG CAAAATGATG TGGTGCTCGG CTGCAGTGGA 240

CATCATGTTT CTGTTAGATG GGTCTAACAG CGTCGGGAAA GGGAGCTTTG AAAGGTCCAA 300

GCACTTTGCC ATCACAGTCT GTGACGGTCT GGACATCAGC CCCGAGAGGG TCAGAGTGGG 360

AGCATTCCAG TTCAGTTCCA CTCCTCATCT GGAATTCCCC TTGGATTCAT TTTCAACCCA 420

ACAGGAAGTG AAGGCAAGAA TCAAGAGGAT GGTTTTCAAA GGAGGGCGCA CGGAGACGGA 480

ACTTGCTCTG AAATACCTTC TGCACAGAGG GTTGCCTGGA GGCAGAAATG CTTCTGTGCC 540

CCAGATCCTC ATCATCGTCA CTGATGGGAA GTCCCAGGGG GATGTGGCAC TGCCATCCAA 600 GCAGCTGAAG GAAAGGGGTG TCACTGTGTT TGCTGTGGGG GTCAGGTTTC CCAGGTGGGA 660

GGAGCTGCAT GCACTGGCCA GCGAGCCTAG AGGGCAGCAC GTGCTGTTGG CTGAGCAGGT 720

GGAGGATGCC ACCAACGGCC TCTTCAGCAC CCTCAGCAGC TCGGCCATCT GCTCCAGCGC 780

CACGCCAGAC TGCAGGGTCG AGGCTCACCC CTGTGAGCAC AGGACGCTGG AGATGGTCCG 840

GGAGTTCGCT GGCAATGCCC CATGCTGGAG AGGATCGCGG CGGACCCTTG CGGTGCTGGC 900

TGCACACTGT CCCTTCTACA GCTGGAAGAG AGTGTTCCTA ACCCACCCTG CCACCTGCTA 960

CAGGACCACC TGCCCAGGCC CCTGTGACTC GCAGCCCTGC GAGAATGGAG GCACATGTGT 1020

TCCAGAAGGA CTGGACGGCT ACCAGTGCCT CTGCCCGCTG GCCTTTGGAG GGGAGGCTAA 1080

CTGTGCCCTG AAGCTGAGCC TGGAATGCAG GGTCGACCTC CTCTTCCTGC TGGACAGCTC 1140

TGCGGGCACC ACTCTGGACG GCTTCCTGCG GGCCAAAGTC TTCGTGAAGC GGTTTGTGCG 1200

GGCCGTGCTG AGCGAGGACT CTCGGGCCCG AGTGGGTGTG GCCACATACA GCAGGGAGCT 1260

GCTGGTGGCG GTGCCTGTGG GGGAGTACCA GGATGTGCCT GACCTGGTCT GGAGCCTCGA 1320

TGGCATTCCC TTCCGTGGTG GCCCCACCCT GACGGGCAGT GCCTTGCGGC AGGCGGCAGA 1380

GCGTGGCTTC GGGAGCGCCA CCAGGACAGG CCAGGACCGG CCACGTAGAG TGGTGGTTTT 1440

GCTCACTGAG TCACACTCCG AGGATGAGGT TGCGGGCCCA GCGCGTCACG CAAGGGCGCG 1500

AGAGCTGCTC CTGCTGGGTG TAGGCAGTGA GGCCGTGCGG GCAGAGCTGG AGGAGATCAC 1560

AGGCAGCCCA AAGCATGTGA TGGTCTACTC GGATCCTCAG GATCTGTTCA ACCAAATCCC 1620

TGAGCTGCAG GGGAAGCTGT GCAGCCGGCA GCGGCCAGGG TGCCGGACAC AAGCCCTGGA 1680

CCTCGTCTTC ATGTTGGACA CCTCTGCCTC AGTAGGGCCC GAGAATTTTG CTCAGATGCA 1740

GAGCTTTGTG AGAAGCTGTG CCCTCCAGTT TGAGGTGAAC CCTGACGTGA CACAGGTCGG 1800

CCTGGTGGTG TATGGCAGCC AGGTGCAGAC TGCCTTCGGG CTGGACACCA AACCCACCCG 1860

GGCTGCGATG CTGCGGGCCA TTAGCCAGGC CCCCTACCTA GGTGGGGTGG GCTCAGCCGG 1920

CACCGCCCTG CTGCACATCT ATGACAAAGT GATGACCGTC CAGAGGGGTG CCCGGCCTGG 1980

TGTCCCCAAA GCTGTGGTGG TGCTCACAGG CGGGAGAGGC GCAGAGGATG CAGCCGTTCC 2040

TGCCCAGAAG CTGAGGAACA ATGGCATCTC TGTCTTGGTC GTGGGCGTGG GGCCTGTCCT 2100

AAGTGAGGGT CTGCGGAGGC TTGCAGGTCC CCGGGATTCC CTGATCCACG TGGCAGCTTA 2160

CGCCGACCTG CGGTACCACC AGGACGTGCT CATTGAGTGG CTGTGTGGAG AAGCCAAGCA 2220

GCCAGTCAAC CTCTGCAAAC CCAGCCCGTG CATGAATGAG GGCAGCTGCG TCCTGCAGAA 2280

TGGGAGCTAC CGCTGCAAGT GTCGGGATGG CTGGGAGGGC CCCCACTGCG AGAACCGATT 2340

CTTGAGACGC CCCTGAGGCA CATGGCTCCC GTGCAGGAGG GCAGCAGCCG TACCCCTCCC 2400

AGCAACTACA GAGAAGGCCT GGGCACTGAA ATGGTGCCTA CCTTCTGGAA TGTCTGTGCC 2460

CCAGGTCCTT AGAATGTCTG CTTCCCGCCG TGGCCAGGAC CACTATTCTC ACTGAGGGAG 2520

GAGGATGTCC CAACTGCAGC CATGCTGCTT AGAGACAAGA AAGCAGCTGA TGTCACCCAC 2580

AAACGATGTT GTTGAAAAGT TTTGATGTGT AAGTAAATAC CCACTTTCTG TACCTGCTGT 2640 GCCTTGTTGA GGCTATGTCA TCTGCCACCT TTCCCTTGAG GATAAACAAG GGGTCCTGAA 2700

GACTTAAATT TAGCGGCCTG ACGTTCCTTT GCACACAATC AATGCTCGCC AGAATGTTGT 2760 TGACACAGTA ATGCCCAGCA GAGGCCTTTA CTAGAGCATC CTTTGGACGG

Seq ID NO: 445 Protein sequence Protein Accession ft: Eos sequence

1 11 21 31 41 51

I I I I I I

MPPFLLLEAV CVFLFSRVPP SLPLQEVHVS KETIGKISAA SKMMWCSAAV DIMFLLDGSN 60 SVGKGSFERS KHFAITVCDG LDISPERVRV GAFQFSSTPH LEFPLDSFST QQEVKARIKR 120

MVFKGGRTET ELALKYLLHR GLPGGRNASV PQILIIVTDG KSQGDVALPS KQLKERGVTV 180

FAVGVRFPRW EELHALASEP RGQHVLLAEQ VEDATNGLFS TLSSSAICSS ATPDCRVEAH 240

PCEHRTLEMV REFAGNAPCW RGSRRTLAVL AAHCPFYSWK RVFLTHPATC YRTTCPGPCD 300

SQPCQNGGTC VPEGLDGYQC LCPLAFGGEA NCALKLSLEC RVDLLFLLDS SAGTTLDGFL 360 RAKVFVKRFV RAVLSEDSRA RVGVATYSRE LLVAVPVGEY QDVPDLVWSL DGIPFRGGPT 420

LTGSALRQAA ERGFGSATRT GQDRPRRVW LLTESHSEDE VAGPARHARA RELLLLGVGS 480

EAVRAELEEI TGSPKHVMVY SDPQDLFNQI PELQGKLCSR QRPGCRTQAL DLVFMLDTSA 540

SVGPENFAQM QSFVRSCALQ FEVNPDVTQV GL YGSQVQ TAFGLDTKPT RAAMLRAISQ 600

APYLGGVGSA GTALLHIYDK VMTVQRGARP GVPKAVWLT GGRGAEDAAV PAQKLRNNGI 660 SVLWGVGPV LSEGLRRLAG PRDSLIHVAA YADLRYHQDV LIEWLCGEAK QPVNLCKPSP 720

CMNEGSCVLQ NGSYRCKCRD GWEGPHCENR FLRRP

Seq ID NO: 446 DNA sequence Nucleic Acid Accession ft: NM_031942.1 Coding sequence: 145..1260

1 11 21 31 41 51

I I I I I I

CCCGAGCCCC GCCCCTCCGG GCCCGGGTCβ GCGCGCCCAG CCTGCCAGCC GCGCTGCTGC 60 TGCTCCTCCT GCTGTGGGAC CGCTGACCGC GCGGCTGCTC CGCTCTCCCC GCTCCAAGCG 120

CCGATCTGGG CACCCGCCAC CAGCATGGAC GCTCGCCGCG TGCCGCAGAA AGATCTCAGA 180

GTAAAGAAGA ACTTAAAGAA ATTCAGATAT GTGAAGTTGA TTTCCATGGA AACCTCGTCA 240

TCCTCTGATG ACAGTTGTGA CAGCTTTGCT TCTGATAATT TTGCAAACAC GAGGCTGCAG 300

TCAGTTCGGG AAGGCTGTAG GACCCGCAGC CAGTGCAGGC ACTCTGGACC TCTCAGGGTG 360 GCGATGAAGT TTCCAGCGCG GAGTACCAGG GGAGCAACCA ACAAAAAAGC AGAGTCCCGC 420

CAGCCCTCAG AGAATTCTGT GACTGATTCC AACTCCGATT CAGAAGATGA AAGTGGAATG 480

AATTTTTTGG AGAAAAGGGC TTTAAATATA AAGCAAAACA AAGCAATGCT TGCAAAACTC 540

ATGTCTGAAT TAGAAAGCTT CCCTGGCTCG TTCCGTGGAA GACATCCCCT CCCAGGCTCC 600

GACTCACAAT CAAGGAGACC GCGAAGGCGT ACATTCCCGG GTGTTGCTTC CAGGAGAAAC 660 CCTGAACGGA GAGCTCGTCC TCTTACCAGG TCAAGGTCCC GGATCCTCGG GTCCCTTGAC 720

GCTCTACCCA TGGAGGAGGA GGAGGAAGAG GATAAGTACA TGTTGGTGAG AAAGAGGAAG 780

ACCGTGGATG GCTACATGAA TGAAGATGAC CTGCCCAGAA GCCGTCGCTC CAGATCATCC 840

GTGACCCTTC CGCATATAAT TCGCCCAGTG GAAGAAATTA CAGAGGAGGA GTTGGAGAAC 900

GTCTGCAGCA ATTCTCGAGA GAAGATATAT AACCGTTCAC TGGGCTCTAC TTGTCATCAA 960 TGCCGTCAGA AGACTATTGA TACCAAAACA AACTGCAGAA ACCCAGACTG CTGGGGCGTT 1020

CGAGGCCAGT TCTCTGGCCC CTGCCTTCGA AACCGTTATG GTGAAGAGGT CAGGGATGCT 1080

CTGCTGGATC CGAACTGGCA TTGCCCGCCT TGTCGAGGAA TCTGCAACTG CAGTTTCTGC 1140

CGGCAGCGAG ATGGACGGTG TGCGACTGGG GTCCTTGTGT ATTTAGCCAA ATATCATGGC 1200

TTTGGGAATG TGCATGCCTA CTTGAAAAGC CTGAAACAGG AATTTGAAAT GCAAGCATAA 1260 TATCTGGAAA ATTTGCTGCC TGCCTTCTAC TTCTCAAATC TTTCTTGTAA AAGTTTCCAA 1320

TTTTTTCACT GAAACCTGAG TTAAAAATCT TGATGATCAG CCTGTTTCAT AAGAAACTCC 1380

AATCAAGTTA ATCTTAGCAG ACATGTGTTT CTGGAGCATC ACAGAAGGTA TATTGCTAGT 1440 TACACTTTGC CCTCCTGCAG TTTCTTCTCT GCTCCCAACC CCCATCTCAT AGCATCCCCC 1500

TCTATTTCCA ATGCTCCTCT CCAACCGCTT AGTTTCTGAA TTTCTTTTAA ATTACAGTTT 1560

TATGAAAGCA TATTTTATTT ACTTGGTGTT GAAATAGCCC TCATAAAACC TAAGCACTTG 1620

GAAACACAAT AATAGTATTA ACTAACTAGA TCTATTGAAT TTCAGAGAAG AGCCTTCTAA 1680

CTTGTTTACA CAAAAACGAG TATGATTTAG CACTCATACT AGTTGAAATT TTTAATAGAA 1740

TCAAGGCACA AAAGTCTTAA AACCATGTGG AAAAATTAGG TAATTATTGC AGATTGATGT 1800

CTCTCAATCC CATGTATTGC GCTTATGTTA CAAGTTGTTG TCACAGTTGA GACTTAATTT 1860

CTCCTAATTT CTTCTGCCCG AAGGGTAAGT GGTGCGTCCA GCTTACACGA TCATAATTCA 1920

AAGGTTGGTG GGCAATGTAA TACTTAATTA AAATAATGAT GGAAGAGCTA TCTGGAGATT 1980

ATGAGTAAGC TGATTTGAAT TTTCAGTATA AAACTTTAGT ATAATTGTAG TTTGCAAAGT 2040

TTATTTCAGT TCACATGTAA GGTATTGCAA ATAAATTCTT GGACAATTTT GTATGGAAAC 2100

TTGATATTAA AAACTAGTCT GTGGTTCTTT GCAGTTTCTT GTAAATTTAT AAACCAGGCA 2160

CAAGGTTCAA GTTTAGATTT TAAGCACTTT TATAACAATG ATAAGTGCCT TTTTGGAGAT 2220

GTAACTTTTA GCAGTTTGTT AACCTGACAT CTCTGCCAGT CTAGTTTCTG GGCAGGTTTC 2280

CTGTGTCAGT ATTCCCCCTC CTCTTTGCAT TAATCAAGGT ATTTGGTAGA GGTGGAATCT 2340

AAGTGTTTGT ATGTCCAATT TACTTGCATA TGTAAACCAT TGCTGTGCCA TTCAATGTTT 2400

GATGCATAAT TGGACCTTGA ATCGATAAGT GTAAATACAG CTTTTGATCT GTAATGCTTT 2460 TATACAAAAG TTTATTTTAA TAATAAAATG TTTGTTCTAA AAAAAAAAAA

Seq ID NO: 447 Protein sequence Protein Accession ft: NP 114148.1

11 21 31 41 51

I

MDARRVPQKD L IRVKKNLKKF RYVKLISMET S ISSSDDSCDS FASDNFANTR L IQSVREGCRT 60 RSQCRHSGPL RVAMKFPARS TRGATNKKAE SRQPSENSVT DSNSDSEDES GMNFLEKRAL 120 NIKQNKAMLA KLMSELESFP GSFRGRHPLP GSDSQSRRPR RRTFPGVASR RNPERRARPL 180 TRSRSRILGS LDALPMEEEE EEDKYMLVRK RKTVDGYMNE DDLPRSRRSR SSVTLPHIIR 240 PVEEITEEEL ENVCSNSREK IYNRSLGSTC HQCRQKTIDT KTNCRNPDCW GVRGQFCGPC 300 LRNRYGEEVR DALLDPNWHC PPCRGICNCS FCRQRDGRCA TGVLVYLAKY HGFGNVHAYL 360 KSLKQEFEMQ A

Seq ID NO: 448 DNA sequence

Nucleic Acid Accession ft: NM_019894

Coding sequence: 1..1314

11 21 31 41 51

ATGTTACAGG ATCCTGACAG TGATCAACCT CTGAACAGCC TCGATGTCAA ACCCCTGCGC 60 AAACCCCGTA TCCCCATGGA GACCTTCAGA AAGGTGGGGA TCCCCATCAT CATAGCACTA 120 CTGAGCCTGG CGAGTATCAT CATTGTGGTT GTCCTCATCA AGGTGATTCT GGATAAATAC 180 TACTTCCTCT GCGGGCAGCC TCTCCACTTC ATCCCGAGGA AGCAGCTGTG TGACGGAGAG 240 CTGGACTGTC CCTTGGGGGA GGACGAGGAG CACTGTGTCA AGAGCTTCCC CGAAGGGCCT 300 GCAGTGGCAG TCCGCCTCTC CAAGGACCGA TCCACACTGC AGGTGCTGGA CTCGGCCACA 360 GGGAACTGGT TCTCTGCCTG TTTCGACAAC TTCACAGAAG CTCTCGCTGA GACAGCCTGT 420 AGGCAGATGG GCTACAGCAG CAAACCCACT TTCAGAGCTG TGGAGATTGG CCCAGACCAG 480 GATCTGGATG TTGTTGAAAT CACAGAAAAC AGCCAGGAGC TTCGCATGCG GAACTCAAGT 540 GGGCCCTGTC TCTCAGGCTC CCTGGTCTCC CTGCACTGTC TTGCCTGTGG GAAGAGCCTG 600 AAGACCCCCC GTGTGGTGGG TGGGGAGGAG GCCTCTGTGG ATTCTTGGCC TTGGCAGGTC 660 AGCATCCAGT ACGACAAACA GCACGTCTGT GGAGGGAGCA TCCTGGACCC CCACTGGGTC 720 CTCACGGCAG CCCACTGCTT CAGGAAACAT ACCGATGTGT TCAACTGGAA GGTGCGGGCA 780 GGCTCAGACA AACTGGGCAG CTTCCCATCC CTGGCTGTGG CCAAGATCAT CATCATTGAA 840 TTCAACCCCA TGTACCCCAA AGACAATGAC ATCGCCCTCA TGAAGCTGCA GTTCCCACTC 900 ACTTTCTCAG GCACAGTCAG GCCCATCTGT CTGCCCTTCT TTGATGAGGA GCTCACTCCA 960 GCCACCCCAC TCTGGATCAT TGGATGGGGC TTTACGAAGC AGAATGGAGG GAAGATGTCT 1020 GACATACTGC TGCAGGCGTC AGTCCAGGTC ATTGACAGCA CACGGTGCAA TGCAGACGAT 1080 GCGTACCAGG GGGAAGTCAC CGAGAAGATG ATGTGTGCAG GCATCCCGGA AGGGGGTGTG 1140 GACACCTGCC AGGGTGACAG TGGTGGGCCC CTGATGTACC AATCTGACCA GTGGCATGTG 1200 GTGGGCATCG TTAGCTGGGG CTATGGCTGC GGGGGCCCGA GCACCCCAGG AGTATACACC 1260 AAGGTCTCAG CCTATCTCAA CTGGATCTAC AATGTCTGGA AGGCTGAGCT GTAA

Seq ID NO: 449 Protein sequence Protein Accession ft: NP 063947.1

11 21 31 41 51

MLQDPDSDQP LNSLDVKPLR KPRIPMETFR KVGIPIIIAL LSLASIIIW VLIKVILDKY 60 YFLCGQPLHF IPRKQLCDGE LDCPLGEDEE HCVKSFPEGP AVAVRLSKDR STLQVLDSAT 120 GNWFSACFDN FTEALAETAC RQMGYSSKPT FRAVEIGPDQ DLDWEITEN SQELRMRNSS 180 GPCLSGSLVS LHCLACGKSL KTPRWGGEE ASVDSWPWQV SIQYDKQHVC GGSILDPHWV 240 LTAAHCFRKH TDVFNWKVRA GSDKLGSFPS LAVAKIIIIE FNPMYPKDND lALMKLQFPL 300 TFSGTVRPIC LPFFDEELTP ATPLWIIGWG FTKQNGGKMS DILLQASVQV IDSTRCNADD 360 AYQGEVTEKM MCAGIPEGGV DTCQGDSGGP LMYQSDQWHV VGIVSWGYGC GGPSTPGVYT 420

Seq ID NO: 450 DNA sequence

Nucleic Acid Accession ft: XM_051860.2

Coding sequence: 52..3042

11 21 31 41 51

GCTCACCCAG GAAAAATATG CAATCGTCCC ATTGATATAC AGGCCACTAC AATGGATGGA 60 GTTAACCTCA GCACCGAGGT TGTCTACAAA AAAGGCCAGG ATTATAGGTT TGCTTGCTAC 120 GACCGGGGCA GAGCCTGCCG GAGCTACCGT GTACGGTTCC TCTGTGGGAA GCCTGTGAGG 180 CCCAAACTCA CAGTCACCAT TGACACCAAT GTGAACAGCA CCATTCTGAA CTTGGAGGAT 240 AATGTACAGT CATGGAAACC TGGAGATACC CTGGTCATTG CCAGTACTGA TTACTCCATG 300 TACCAGGCAG AAGAGTTCCA GGTGCTTCCC TGCAGATCCT GCGCCCCCAA CCAGGTCAAA 360 GTGGCAGGGA AACCAATGTA CCTGCACATC GGGGAGGAGA TAGACGGCGT GGACATGCGG 420 GCGGAGGTTG GGCTTCTGAG CCGGAACATC ATAGTGATGG GGGAGATGGA GGACAAATGC 480 TACCCCTACA GAAACCACAT CTGCAATTTC TTTGACTTCG ATACCTTTGG GGGCCACATC 540 AAGTTTGCTC TGGGATTTAA GGCAGCACAC TTGGAGGGCA CGGAGCTGAA GCATATGGGA 600 CAGCAGCTGG TGGGTCAGTA CCCGATTCAC TTCCACCTGG CCGGTGATGT AGACGAAAGG 660 GGAGGTTATG ACCCACCCAC ATACATCAGG GACCTCTCCA TCCATCATAC ATTCTCTCGC 720 TGCGTCACAG TCCATGGCTC CAATGGCTTG TTGATCAAGG ACGTTGTGGG CTATAACTCT 780 TTGGGCCACT GCTTCTTCAC GGAAGATGGG CCGGAGGAAC GCAACACTTT TGACCACTGT 840 CTTGGCCTCC TTGTCAAGTC TGGAACCCTC CTCCCCTCGG ACCGTGACAG CAAGATGTGC 900 AAGATGATCA CAGGAGACTC CTACCCAGGG TACATCCCCA AGCCCAGGCA AGACTGCAAT 960

GCTGTGTCCA CCTTCTGGAT GGCCAATCCC AACAACAACC TCATCAACTG TGCCGCTGCA 1020

GGATCTGAGG AAACTGGATT TTGGTTTATT TTTCACCACG TACCAACGGG CCCCTCCGTG 1080

GGAATGTACT CCCCAGGTTA TTCAGAGCAC ATTCCACTGG GAAAATTCTA TAACAACCGA 1140

GCACATTCCA ACTACCGGGC TGGCATGATC ATAGACAACG GAGTCAAAAC CACCGAGGCC 1200

TCTGCCAAGG ACAAGCGGCC GTTCCTCTCA ATCATCTCTG CCAGATACAG CCCTCACCAG 1260

GACGCCGACC CGCTGAAGCC CCGGGAGCCG GCCATCATCA GACACTTCAT TGCCTACAAG 1320

AACCAGGACC ACGGGGCCTG GCTGCGCGGC GGGGATGTGT GGCTGGACAG CTGCCGGTTT 1380

GCTGACAATG GCATTGGCCT GACCCTGGCC AGTGGTGGAA CCTTCCCGTA TGACGACGGC 1440

TCCAAGCAAG AGATAAAGAA CAGCTTGTTT GTTGGCGAGA GTGGCAACGT GGGGACGGAA 1500

ATGATGGACA ATAGGATCTG GGGCCCTGGC GGCTTGGACC ATAGCGGAAG GACCCTCCCT 1560

ATAGGCCAGA ATTTTCCAAT TAGAGGAATT CAGTTATATG ATGGCCCCAT CAACATCCAA 1620

AACTGCACTT TCCGAAAGTT TGTGGCCCTG GAGGGCCGGC ACACCAGCGC CCTGGCCTTC 1680

CGCCTGAATA ATGCCTGGCA GAGCTGCCCC CATAACAACG TGACCGGCAT TGCCTTTGAG 1740

GACGTTCCGA TTACTTCCAG AGTGTTCTTC GGAGAGCCTG GGCCCTGGTT CAACCAGCTG 1800

GACATGGATG GGGATAAGAC ATCTGTGTTC CATGACGTCG ACGGCTCCGT GTCCGAGTAC 1860

CCTGGCTCCT ACCTCACGAA GAATGACAAC TGGCTGGTCC GGCACCCAGA CTGCATCAAT 1920

GTTCCCGACT GGAGAGGGGC CATTTGCAGT GGGTGCTATG CACAGATGTA CATTCAAGCC 1980

TACAAGACCA GTAACCTGCG AATGAAGATC ATCAAGAATG ACTTCCCCAG CCACCCTCTT 2040

TACCTGGAGG GGGCGCTCAC CAGGAGCACC CATTACCAGC AATACCAACC GGTTGTCACC 2100

CTGCAGAAGG GCTACACCAT CCACTGGGAC CAGACGGCCC CCGCCGAACT CGCCATCTGG 2160

CTCATCAACT TCAACAAGGG CGACTGGATC CGAGTGGGGC TCTGCTACCC GCGAGGCACC 2220

ACATTCTCCA TCCTCTCGGA TGTTCACAAT CGCCTGCTGA AGCAAACGTC CAAGACGGGC 2280

GTCTTCGTGA GGACCTTGCA GATGGACAAA GTGGAGCAGA GCTACCCTGG CAGGAGCCAC 2340

TACTACTGGG ACGAGGACTC AGGGCTGTTG TTCCTGAAGC TGAAAGCTCA GAACGAGAGA 2400

GAGAAGTTTG CTTTCTGCTC CATGAAAGGC TGTGAGAGGA TAAAGATTAA AGCTCTGATT 2460

CCAAAGAACG CAGGCGTCAG TGACTGCACA GCCACAGCTT ACCCCAAGTT CACCGAGAGG 2520

GCTGTCGTAG ACGTGCCGAT GCCCAAGAAG CTCTTTGGTT CTCAGCTGAA AACAAAGGAC 2580

CATTTCTTGG AGGTGAAGAT GGAGAGTTCC AAGCAGCACT TCTTCCACCT CTGGAACGAC 2640

TTCGCTTACA TTGAAGTGGA TGGGAAGAAG TACCCCAGTT CGGAGGATGG CATCCAGGTG 2700

GTGGTGATTG ACGGGAACCA AGGGCGCGTG GTGAGCCACA CGAGCTTCAG GAACTCCATT 2760

CTGCAAGGCA TACCATGGCA GCTTTTCAAC TATGTGGCGA CCATCCCTGA CAATTCCATA 2820

GTGCTTATGG CATCAAAGGG AAGATACGTC TCCAGAGGCC CATGGACCAG AGTGCTGGAA 2880

AAGCTTGGGG CAGACAGGGG TCTCAAGTTG AAAGAGCAAA TGGCATTCGT TGGCTTCAAA 2940

GGCAGCTTCC GGCCCATCTG GGTGACACTG GACACTGAGG ATCACAAAGC CAAAATCTTC 3000

CAAGTTGTGC CCATCCCTGT GGTGAAGAAG AAGAAGTTGT GAGGACAGCT GCCGCCCGGT 3060

GCCACCTCGT GGTAGACTAT GACGGTGACT CTTGGCAGCA GACCAGTGGG GGATGGCTGG 3120

GTCCCCCAGC CCCTGCCAGG AGCTGCCTGG GAAGGCCGTG TTTCAGCCCT GATGGGCCAA 3180

GGGAAGGCTA TCAGAGACCC TGGTGCTGCC ACCTGCCCCT ACTCAAGTGT CTACCTGGAG 3240

CCCCTGGGGC GGTGCTGGCC AATGCTGGAA ACATTCACTT TCCTGCAGCC TCTTGGGTGC 3300

TTCTCTCCTA TCTGTGCCTC TTCAGTGGGG GTTTGGGGAC CATATCAGGA GACCTGGGTT 3360

GTGCTGACAG CAAAGATCCA CTTTGGCAGG AGCCCTGACC CAGCTAGGAG GTAGTCTGGA 3420

GGGCTGGTCA TTCACAGATC CCCATGGTCT TCAGCAGACA AGTGAGGGTG GTAAATGTAG 3480

GAGAAAGAGC CTTGGCCTTA AGGAAATCTT TACTCCTGTA AGCAAGAGCC AACCTCACAG 3540

GATTAGGAGC TGGGGTAGAA CTGGCTATCC TTGGGGAAGA GGCAAGCCCT GCCTCTGGCC 3600

GTGTCCACCT TTCAGGAGAC TTTGAGTGGC AGGTTTGGAC TTGGACTAGA TGACTCTCAA 3660

AGGCCCTTTT AGTTCTGAGA TTCCAGAAAT CTGCTGCATT TCACATGGTA CCTGGAACCC 3720

AACAGTTCAT GGATATCCAC TGATATCCAT GATGCTGGGT GCCCCAGCGC ACACGGGATG 3780

GAGAGGTGAG AACTAATGCC TAGCTTGAGG GGTCTGCAGT CCAGTAGGGC AGGCAGTCAG 3840

GTCCATGTGC ACTGCAATGC CAGGTGGAGA AATCACAGAG AGGTAAAATG GAGGCCAGTG 3900

CCATTTCAGA GGGGAGGCTC AGGAAGGCTT CTTGCTTACA GGAATGAAGG CTGGGGGCAT 3960

TTTGCTGGGG GGAGATGAGG CAGCCTCTGG AATGGCTCAG GGATTCAGCC CTCCCTGCCG 4020

CTGCCTGCTG AAGCTGGTGA CTACGGGGTC GCCCTTTGCT CACGTCTCTC TGGCCCACTC 4080

ATGATGGAGA AGTGTGGTCA GAGGGGAGCA ATGGGCTTTG CTGCTTATGA GCACAGAGGA 4140

ATTCAGTCCC CAGGCAGCCC TGCCTCTGAC TCCAAGAGGG TGAAGTCCAC AGAAGTGAGC 4200

TCCTGCCTTA GGGCCTCATT TGCTCTTCAT CCAGGGAACT GAGCACAGGG GGCCTCCAGG 4260

AGACCCTAGA TGTGCTCGTA CTCCCTCGGC CTGGGATTTC AGAGCTGGAA ATATAGAAAA 4320

TATCTAGCCC AAAGCCTTCA TTTTAACAGA TGGGGAAAGT GAGCCCCCAA GATGGGAAAG 4380

AACCACACAG CTAAGGGAGG GCCTGGGGAG CCCCACCCTA GCCCTTGCTG CCACACCACA 4440

TTGCCTCAAC AACCGGCCCC AGAGTGCCCA GGCACTCCTG AGGTAGCTTC TGGAAATGGG 4500

GACAAGTCCC CTCGAAGGAA AGGAAATGAC TAGAGTAGAA TGACAGCTAG CAGATCTCTT 4560

CCCTCCTGCT CCCAGCGCAC ACAAACCCGC CCTCCCCTTG GTGTTGGCGG TCCCTGTGGC 4620

CTTCACTTTG TTCACTACCT GTCAGCCCAG CCTGGGTGCA CAGTAGCTGC AACTCCCCAT 4680

TGGTGCTACC TGGCTCTCCT GTCTCTGCAG CTCTACAGGT GAGGCCCAGC AGAGGGAGTA 4740

GGGCTCGCCA TGTTTCTGGT GAGCCAATTT GGCTGATCTT GGGTGTCTGA ACAGCTATTG 4800

GGTCCACCCC AGTCCCTTTC AGCTGCTGCT TAATGCCCTG CTCTCTCCCT GGCCCACCTT 4860

ATAGAGAGCC CAAAGAGCTC CTGTAAGAGG GAGAACTCTA TCTGTGGTTT ATAATCTTGC 4920

ACGAGGCACC AGAGTCTCCC TGGGTCTTGT GATGAACTAC ATTTATCCCC TTTCCTGCCC 4980

CAACCACAAA CTCTTTCCTT CAAAGAGGGC CTGCCTGGCT CCCTCCACCC AACTGCACCC 5040

ATGAGACTCG GTCCAAGAGT CCATTCCCCA GGTGGGAGCC AACTGTCAGG GAGGTCTTTC 5100

CCACCAAACA TCTTTCAGCT GCTGGGAGGT GACCATAGGG CTCTGCTTTT AAAGATATGG 5160

CTGCTTCAAA GGCCAGAGTC ACAGGAAGGA CTTCTTCCAG GGAGATTAGT GGTGATGGAG 5220

AGGAGAGTTA AAATGACCTC ATGTCCTTCT TGTCCACGGT TTTGTTGAGT TTTCACTCTT 5280

CTAATGCAAG GGTCTCACAC TGTGAACCAC TTAGGATGTG ATCACTTTCA GGTGGCCAGG 5340

AATGTTGAAT GTCTTTGGCT CAGTTCATTT AAAAAAGATA TCTATTTGAA AGTTCTCAGA 5400

GTTGTACATA TGTTTCACAG TACAGGATCT GTACATAAAA GTTTCTTTCC TAAACCATTC 5460

ACCAAGAGCC AATATCTAGG CATTTTCTTG GTAGCACAAA TTTTCTTATT GCTTAGAAAA 5520

TTGTCCTCCT TGTTATTTCT GTTTGTAAGA CTTAAGTGAG TTAGGTCTTT AAGGAAAGCA 5580 ACGCTCCTCT GAAATGCTTG TCTTTTTTCT GTTGCCGAAA TAGCTGGTCC TTTTTCGGGA 5640

GTTAGATGTA TAGAGTGTTT GTATGTAAAC ATTTCTTGTA GGCATCACCA TGAACAAAGA 5700

TATATTTTCT ATTTATTTAT TATATGTGCA CTTCAAGAAG TCACTGTCAG AGAAATAAAG 5760 AATTGTCTTA AATGTCAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAA

Seq ID NO: 451 Protein sequence Protein Accession ft: XP_051860.2

10 1 11 21 31 41 51

MDGVNLSTEV VYKKGQDYRF ACYDRGRACR SYRVRFLCGK PVRPKLTVTI DTNVNSTILN 60

LEDNVQSWKP GDTLVIASTD YSMYQAEEFQ VLPCRSCAPN QVKVAGKPMY LHIGEEIDGV 120

DMRAEVGLLS RNIIVMGEME DKCYPYRNHI CNFFDFDTFG GHIKFALGFK AAHLEGTELK 180

15 HMGQQLVGQY PIHFHLAGDV DERGGYDPPT YIRDLSIHHT FSRCVTVHGS NGLLIKDWG 240

YNSLGHCFFT EDGPEERNTF DHCLGLLVKS GTLLPSDRDS KMCKMITGDS YPGYIPKPRQ 300

DCNAVSTFWM ANPNNNLINC AAAGSEETGF WFIFHHVPTG PSVGMYSPGY SEHIPLGKFY 360

NNRAHSNYRA GMIIDNGVKT TEASAKDKRP FLSIISARYS PHQDADPLKP REPAIIRHFI 420

AYKNQDHGAW LRGGDVWLDS CRFADNGIGL TLASGGTFPY DDGSKQEIKN SLFVGESGNV 480

20 GTEMMDNRIW GPGGLDHSGR TLPIGQNFPI RGIQLYDGPI NIQNCTFRKF VALEGRHTSA 540

LAFRLNNAWQ SCPHNNVTGI AFEDVPITSR VFFGEPGPWF NQLDMDGDKT SVFHDVDGSV 600

SEYPGSYLTK NDNWLVRHPD CINVPDWRGA ICSGCYAQMY IQAYKTSNLR MKIIKNDFPS 660

HPLYLEGALT RSTHYQQYQP TLQKGYTI HWDQTAPAEL AIWLINFNKG DWIRVGLCYP 720

RGTTFSILSD VHNRLLKQTS KTGVFVRTLQ MDKVEQSYPG RSHYYWDEDS GLLFLKLKAQ 780

25 NEREKFAFCS MKGCERIKIK ALIPKNAGVS DCTATAYPKF TERAWDVPM PKKLFGSQLK 840

TKDHFLEVKM ESSKQHFFHL WNDFAYIEVD GKKYPSSEDG IQWVIDGNQ GRWSHTSFR 900

NSILQGIPWQ LFNYVATIPD NSIVLMASKG RYVSRGPWTR VLEKLGADRG LKLKEQMAFV 960 GFKGSFRPIW VTLDTEDHKA KIFQWPIPV VKKKKL

30 Seq ID NO: 452 DNA sequence

Nucleic Acid Accession ft: Eos sequence Coding sequence: 261..2861

_ _ 1 11 21 31 41 51

35 i i i i i i

GAGCTAGCGC TCAAGCAGAG CCCAGCGCGG TGCTATCGGA CAGAGCCTGG CGAGCGCAAG 60

CGGCGCGGGG AGCCAGCGGG GCTGAGCGCG GCCAGGGTCT GAACCCAGAT TTCCCAGACT 120

AGCTACCACT CCGCTTGCCC ACGCCCCGGG AGCTCGCGGC GCCTGGCGGT CAGCGACCAG 180

ACGTCCGGGG CCGCTGCGCT CCTGGCCCGC GAGGCGTGAC ACTGTCTCGG CTACAGACCC 240

40 AGAGGGAGCA CACTGCCAGG ATGGGAGCTG CTGGGAGGCA GGACTTCCTC TTCAAGGCCA 300

TGCTGACCAT CAGCTGGCTC ACTCTGACCT GCTTCCCTGG GGCCACATCC ACAGTGGCTG 360

CTGGGTGCCC TGACCAGAGC CCTGAGTTGC AACCCTGGAA CCCTGGCCAT GACCAAGACC 420

ACCATGTGCA TATCGGCCAG GGCAAGACAC TGCTGCTCAC CTCTTCTGCC ACGGTCTATT 480

CCATCCACAT CTCAGAGGGA GGCAAGCTGG TCATTAAAGA CCACGACGAG CCGATTGTTT 540

45 TGCGAACCCG GCACATCCTG ATTGACAACG GAGGAGAGCT GCATGCTGGG AGTGCCCTCT 600

GCCCTTTCCA GGGCAATTTC ACCATCATTT TGTATGGAAG GGCTGATGAA GGTATTCAGC 660

CGGATCCTTA CTATGGTCTG AAGTACATTG GGGTTGGTAA AGGAGGCGCT CTTGAGTTGC 720

ATGGACAGAA AAAGCTCTCC TGGACATTTC TGAACAAGAC CCTTCACCCA GGTGGCATGG 780

CAGAAGGAGG CTATTTTTTT GAAAGGAGCT GGGGCCACCG TGGAGTTATT GTTCATGTCA 840

50 TCGACCCCAA ATCAGGCACA GTCATCCATT CTGACCGGTT TGACACCTAT AGATCCAAGA 900

AAGAGAGTGA ACGTCTGGTC CAGTATTTGA ACGCGGTGCC CGATGGCAGG ATCCTTTCTG 960

TTGCAGTGAA TGATGAAGGT TCTCGAAATC TGGATGACAT GGCCAGGAAG GCGATGACCA 1020

AATTGGGAAG CAAACACTTC CTGCACCTTG GATTTAGACA CCCTTGGAGT TTTCTAACTG 1080

TGAAAGGAAA TCCATCATCT TCAGTGGAAG ACCATATTGA ATATCATGGA CATCGAGGCT 1140

55 CTGCTGCTGC CCGGGTATTC AAATTGTTCC AGACAGAGCA TGGCGAATAT TTCAATGTTT 1200

CTTTGTCCAG TGAGTGGGTT CAAGACGTGG AGTGGACGGA GTGGTTCGAT CATGATAAAG 1260

TATCTCAGAC TAAAGGTGGG GAGAAAATTT CAGACCTCTG GAAAGCTCAC CCAGGAAAAA 1320

TATGCAATCG TCCCATTGAT ATACAGGCCA CTACAATGGA TGGAGTTAAC CTCAGCACCG 1380

AGGTTGTCTA CAAAAAAGGC CAGGATTATA GGTTTGCTTG CTACGACCGG GGCAGAGCCT 1440 0 GCCGGAGCTA CCGTGTACGG TTCCTCTGTG GGAAGCCTGT GAGGCCCAAA CTCACAGTCA 1500

CCATTGACAC CAATGTGAAC AGCACCATTC TGAACTTGGA GGATAATGTA CAGTCATGGA 1560

AACCTGGAGA TACCCTGGTC ATTGCCAGTA CTGATTACTC CATGTACCAG GCAGAAGAGT 1620

TCCAGGTGCT TCCCTGCAGA TCCTGCGCCC CCAACCAGGT CAAAGTGGCA GGGAAACCAA 1680

TGTACCTGCA CATCGGGGAG GAGATAGACG GCGTGGACAT GCGGGCGGAG GTTGGGCTTC 1740 5 TGAGCCGGAA CATCATAGTG ATGGGGGAGA TGGAGGACAA ATGCTACCCC TACAGAAACC 1800

ACATCTGCAA TTTCTTTGAC TTCGATACCT TTGGGGGCCA CATCAAGTTT GCTCTGGGAT 1860

TTAAGGCAGC ACACTTGGAG GGCACGGAGC TGAAGCATAT GGGACAGCAG CTGGTGGGTC 1920

AGTACCCGAT TCACTTCCAC CTGGCCGGTG ATGTAGACGA AAGGGGAGGT TATGACCCAC 1980

CCACATACAT CAGGGACCTC TCCATCCATC ATACATTCTC TCGCTGCGTC ACAGTCCATG 2040 0 GCTCCAATGG CTTGTTGATC AAGGACGTTG TGGGCTATAA CTCTTTGGGC CACTGCTTCT 2100

TCACGGAAGA TGGGCCGGAG GAACGCAACA CTTTTGACCA CTGTCTTGGC CTCCTTGTCA 2160

AGTCTGGAAC CCTCCTCCCC TCGGACCGTG ACAGCAAGAT GTGCAAGATG ATCACAGAGG 2220

ACTCCTACCC AGGGTACATC CCCAAGCCCA GGCAAGACTG CAATGCTGTG TCCACCTTCT 2280

GGATGGCCAA TCCCAACAAC AACCTCATCA ACTGTGCCGC TGCAGGATCT GAGGAAACTG 2340 5 GATTTTGGTT TATTTTTCAC CACGTACCAA CGGGCCCCTC CGTGGGAATG TACTCCCCAG 2400

GTTATTCAGA GCACATTCCA CTGGGAAAAT TCTATAACAA CCGAGCACAT TCCAACTACC 2460

GGGCTGGCAT GATCATAGAC AACGGAGTCA AAACCACCGA GGCCTCTGCC AAGGACAAGC 2520

GGCCGTTCCT CTCAATCATC TCTGCCAGAT ACAGCCCTCA CCAGGACGCC GACCCGCTGA 2580

AGCCCCGGGA GCCGGCCATC ATCAGACACT TCATTGCCTA CAAGAACCAG GACCACGGGG 2640 0 CCTGGCTGCG CGGCGGGGAT GTGTGGCTGG ACAGCTGCCA TTTCAGAGGG GAGGCTCAGG 2700

AAGGCTTCTT GCTTACAGGA ATGAAGGCTG GGGGCATTTT GCTGGGGGGA GATGAGGCAG 2760

CCTCTGGAAT GGCTCAGGGA TTCAGCCCTC CCTGCCGCTG CCTGCTGAAG CTGGTGACTA 2820

CGGGGTCGCC CTTTGCTCAC GTCTCTCTGG CCCACTCATG ATGGAGAAGT GTGGTCAGAG 2880

GGGAGCAATG GGCTTTGCTG CTTATGAGCA CAGAGGAATT CAGTCCCCAG GCAGCCCTGC 2940 5 CTCTGACTCC AAGAGGGTGA AGTCCACAGA AGTGAGCTCC TGCCTTAGGG CCTCATTTGC 3000

TCTTCATCCA GGGAACTGAG CACAGGGGGC CTCCAGGAGA CCCTAGATGT GCTCGTACTC 3060

CCTCGGCCTG GGATTTCAGA GCTGGAAATA TAGAAAATAT CTAGCCCAAA GCCTTCATTT 3120 TAACAGATGG GGAAAGTGAG CCCCCAAGAT GGGAAAGAAC CACACAGCTA AGGGAGGGCC 3180

TGGGGAGCCC CACCCTAGCC CTTGCTGCCA CACCACATTG CCTCAACAAC CGGCCCCAGA 3240

GTGCCCAGGC ACTCCTGAGG TAGCTTCTGG AAATGGGGAC AAGTCCCCTC GAAGGAAAGG 3300

AAATGACTAG AGTAGAATGA CAGCTAGCAG ATCTCTTCCC TCCTGCTCCC AGCGCACACA 3360

AACCCGCCCT CCCCTTGGTG TTGGCGGTCC CTGTGGCCTT CACTTTGTTC ACTACCTGTC 3420

AGCCCAGCCT GGGTGCACAG TAGCTGCAAC TCCCCATTGG TGCTACCTGG CTCTCCTGTC 3480

TCTGCAGCTC TACAGGTGAG GCCCAGCAGA GGGAGTAGGG CTCGCCATGT TTCTGGTGAG 3540

CCAATTTGGC TGATCTTGGG TGTCTGAACA GCTATTGGGT CCACCCCAGT CCCTTTCAGC 3600

TGCTGCTTAA TGCCCTGCTC TCTCCCTGGC CCACCTTATA GAGAGCCCAA AGAGCTCCTG 3660

TAAGAGGGAG AACTCTATCT GTGGTTTATA ATCTTGCACG AGGCACCAGA GTCTCCCTGG 3720

GTCTTGTGAT GAACTACATT TATCCCCTTT CCTGCCCCAA CCACAAACTC TTTCCTTCAA 3780

AGAGGGCCTG CCTGGCTCCC TCCACCCAAC TGCACCCATG AGACTCGGTC CAAGAGTCCA 3840

TTCCCCAGGT GGGAGCCAAC TGTCAGGGAG GTCTTTCCCA CCAAACATCT TTCAGCTGCT 3900

GGGAGGTGAC CATAGGGCTC TGCTTTTAAA GATATGGCTG CTTCAAAGGC CAGAGTCACA 3960

GGAAGGACTT CTTCCAGGGA GATTAGTGGT GATGGAGAGG AGAGTTAAAA TGACCTCATG 4020

TCCTTCTTGT CCACGGTTTT GTTGAGTTTT CACTCTTCTA ATGCAAGGGT CTCACACTGT 4080

GAACCACTTA GGATGTGATC ACTTTCAGGT GGCCAGGAAT GTTGAATGTC TTTGGCTCAG 4140

TTCATTTAAA AAAGATATCT ATTTGAAAGT TCTCAGAGTT GTACATATGT TTCACAGTAC 4200

AGGATCTGTA CATAAAAGTT TCTTTCCTAA ACCATTCACC AAGAGCCAAT ATCTAGGCAT 4260

TTTCTTGGTA GCACAAATTT TCTTATTGCT TAGAAAATTG TCCTCCTTGT TATTTCTGTT 4320

TGTAAGACTT AAGTGAGTTA GGTCTTTAAG GAAAGCAACG CTCCTCTGAA ATGCTTGTCT 4380

TTTTTCTGTT GCCGAAATAG CTGGTCCTTT TTCGGGAGTT AGATGTATAG AGTGTTTGTA 4440

TGTAAACATT TCTTGTAGGC ATCACCATGA ACAAAGATAT ATTTTCTATT TATTTATTAT 4500

ATGTGCACTT CAAGAAGTCA CTGTCAGAGA AATAAAGAAT TGTCTTAAAT GTCATGATTG 4560

GAGATGTCCT TTGCATTGCT TGGAAGGGGT GTACCTAGAG CCAAGGAAAT TGGCTCTGGT 4620

TTGGAAAAAT TTTGCTGTTA TTATAGTAAA CATACAAAGG ATCTCAAAAA AAAAAAAAAA 4680 AAAAAAAAAA AAAAAAAAAA AA

Seq ID NO: 453 Protein sequence Protein Accession ft: Eos sequence

11 21 31 41 51

MGAAGRQDFL FKAMLTISWL TLTCFPGATS TVAAGCPDQS PELQPWNPGH DQDHHVHIGQ 60 GKTLLLTSSA TVYSIHISEG GKLVIKDHDE PIVLRTRHIL IDNGGELHAG SALCPFQGNF 120 TIILYGRADE GIQPDPYYGL KYIGVGKGGA LELHGQKKLS WTFLNKTLHP GGMAEGGYFF 180 ERSWGHRGVI VHVIDPKSGT VIHSDRFDTY RSKKESERLV QYLNAVPDGR ILSVAVNDEG 240 SRNLDDMARK AMTKLGSKHF LHLGFRHPWS FLTVKGNPSS SVEDHIEYHG HRGSAAARVF 300 KLFQTEHGEY FNVSLSSEWV QDVEWTEWFD HDKVSQTKGG EKISDLWKAH PGKICNRPID 360 IQATTMDGVN LSTEWYKKG QDYRFACYDR GRACRSYRVR FLCGKPVRPK LTVTIDTNVN 420 STILNLEDNV QSWKPGDTLV IASTDYSMYQ AEEFQVLPCR SCAPNQVKVA GKPMYLHIGE 480 EIDGVDMRAE VGLLSRNIIV MGEMEDKCYP YRNHICNFFD FDTFGGHIKF ALGFKAAHLE 540 GTELKHMGQQ LVGQYPIHFH LAGDVDERGG YDPPTYIRDL SIHHTFSRCV TVHGSNGLLI 600 KDWGYNSLG HCFFTEDGPE ERNTFDHCLG LLVKSGTLLP SDRDSKMCKM ITEDS PGYI 660 PKPRQDCNAV STFWMANPNN NLINCAAAGS EETGFWFIFH HVPTGPSVGM YSPGYSEHIP 720 LGKFYNNRAH SNYRAGMIID NGVKTTEASA KDKRPFLSII SARYSPHQDA DPLKPREPAI 780 IRHFIAYKNQ DHGAWLRGGD VWLDSCHFRG EAQEGFLLTG MKAGGILLGG DEAASGMAQG 840 FSPPCRCLLK LVTTGSPFAH VSLAHS

Seq ID NO: 454 DNA sequence

Nucleic Acid Accession ft: NM_013282.2

Coding sequence: 85..2466

11 21 31 41 51

I I I I

CGACTCCTTA G 1AGCATGGCA TGGCTCAGAG GTGCTGGTAA AACTGATGGG GGTTTTTGCT 60 GTCCCTCCCC TCAGCGCCGA CACCATGTGG ATCCAGGTTC GGACCATGGA CGGGAGGCAG 120 ACCCACACGG TGGACTCGCT GTCCAGGCTG ACCAAGGTGG AGGAGCTGAG GCGGAAGATC 180 CAGGAGCTGT TCCACGTGGA GCCAGGCCTG CAGAGGCTGT TCTACAGGGG CAAACAGATG 240 GAGGACGGCC ATACCCTCTT CGACTACGAG GTCCGCCTGA ATGACACCAT CCAGCTCCTG 300 GTCCGCCAGA GCCTCGTGCT CCCCCACAGC ACCAAGGAGC GGGACTCCGA GCTCTCCGAC 360 ACCGACTCCG GCTGCTGCCT GGGCCAGAGT GAGTCAGACA AGTCCTCCAC CCACGGCGAG 420 GCGGCCGCCG AGACTGACAG CAGGCCAGCC GATGAGGACA TGTGGGATGA GACGGAATTG 480 GGGCTGTACA AGGTCAATGA GTACGTCGAT GCTCGGGACA CGAACATGGG GGCGTGGTTT 540 GAGGCGCAGG TGGTCAGGGT GACGCGGAAG GCCCCCTCCC GGGACGAGCC CTGCAGCTCC 600 ACGTCCAGGC CGGCGCTGGA GGAGGACGTC ATTTACCACG TGAAATACGA CGACTACCCG 660 GAGAACGGCG TGGTCCAGAT GAACTCCAGG GACGTCCGAG CGCGCGCCCG CACCATCATC 720 AAGTGGCAGG ACCTGGAGGT GGGCCAGGTG GTCATGCTCA ACTACAACCC CGACAACCCC 780 AAGGAGCGGG GCTTCTGGTA CGACGCGGAG ATCTCCAGGA AGCGCGAGAC CAGGACGGCG 840 CGGGAACTCT ACGCCAACGT GGTGCTGGGG GATGATTCTC TGAACGACTG TCGGATCATC 900 TTCGTGGACG AAGTCTTCAA GATTGAGCGG CCGGGTGAAG GGAGCCCCAT GGTTGACAAC 960 CCCATGAGAC GGAAGAGCGG GCCGTCCTGC AAGCACTGCA AGGACGACGT GAACAGACTC 1020 TGCCGGGTCT GCGCCTGCCA CCTGTGCGGG GGCCGGCAGG ACCCCGACAA GCAGCTCATG 1080 TGCGATGAGT GCGACATGGC CTTCCACATC TACTGCCTGG ACCCGCCCCT CAGCAGTGTT 1140 CCCAGCGAGG ACGAGTGGTA CTGCCCTGAG TGCCGGAATG ATGCCAGCGA GGTGGTACTG 1200 GCGGGAGAGC GGCTGAGAGA GAGCAAGAAG AAGGCGAAGA TGGCCTCGGC CACATCGTCC 1260 TCACAGCGGG ACTGGGGCAA GGGCATGGCC TGTGTGGGCC GCACCAAGGA ATGTACCATC 1320 GTCCCGTCCA ACCACTACGG ACCCATCCCG GGGATCCCCG TGGGCACCAT GTGGCGGTTC 1380 CGAGTCCAGG TCAGCGAGTC GGGTGTCCAT CGGCCCCACG TGGCTGGCAT ACACGGCCGG 1440 AGCAACGACG GAGCGTACTC CCTAGTCCTG GCGGGGGGCT ATGAGGATGA CGTGGACCAT 1500 GGGAATTTTT TCACATACAC GGGTAGTGGT GGTCGAGATC TTTCCGGCAA CAAGAGGACC 1560 GCGGAACAGT CTTGTGATCA GAAACTCACC AACACCAACA GGGCGCTGGC TCTCAACTGC 1620 TTTGCTCCCA TCAATGACCA AGAAGGGGCC GAGGCCAAGG ACTGGCGGTC GGGGAAGCCG 1680 GTCAGGGTGG TGCGCAATGT CAAGGGTGGC AAGAATAGCA AGTACGCCCC CGCTGAGGGC 1740 AACCGCTACG ATGGCATCTA CAAGGTTGTG AAATACTGGC CCGAGAAGGG GAAGTCCGGG 1800 TTTCTCGTGT GGCGCTACCT TCTGCGGAGG GACGATGATG AGCCTGGCCC TTGGACGAAG 1860 GAGGGGAAGG ACCGGATCAA GAAGCTGGGG CTGACCATGC AGTATCCAGA AGGCTACCTG 1920 GAAGCCCTGG CCAACCGAGA GCGAGAGAAG GAGAACAGCA AGAGGGAGGA GGAGGAGCAG 1980

CAGGAGGGGG GCTTCGCGTC CCCCAGGACG GGCAAGGGCA AGTGGAAGCG GAAGTCGGCA 2040

GGAGGTGGCC CGAGCAGGGC CGGGTCCCCG CGCCGGACAT CCAAGAAAAC CAAGGTGGAG 2100

CCCTACAGTC TCACGGCCCA GCAGAGCAGC CTCATCAGAG AGGACAAGAG CAACGCCAAG 2160

CTGTGGAATG AGGTCCTGGC GTCACTCAAG GACCGGCCGG CGAGCGGCAG CCCGTTCCAG 2220

TTGTTCCTGA GTAAAGTGGA GGAGACGTTC CAGTGTATCT GCTGTCAGGA GCTGGTGTTC 2280

CGGCCCATCA CGACCGTGTG CCAGCACAAC GTGTGCAAGG ACTGCCTGGA CAGATCCTTT 2340

CGGGCACAGG TGTTCAGCTG CCCTGCCTGC CGCTACGACC TGGGCCGCAG CTATGCCATG 2400

CAGGTGAACC AGCCTCTGCA GACCGTCCTC AACCAGCTCT TCCCCGGCTA CGGCAATGGC 2460

CGGTGATCTC CAAGCACTTC TCGACAGGCG TTTTGCTGAA AACGTGTCGG AGGGCTCGTT 2520

CATCGGCACT GATTTTGTTC TTAGTGGGCT TAACTTAAAC AGGTAGTGTT TCCTCCGTTC 2580

CCTAAAAAGG TTTGTCTTCC TTTTTTTTTA TTTTTATTTT TCAAATCTAT ACATTTTCAG 2640

GAATTTATGT ATTCTGGCTA AAAGTTGGAC TTCTCAGTAT TGTGTTTAGT TCTTTGAAAA 2700

CATAAAAGCC TGCAATTTCT CGACAAAACA ACACAAGATT TTTTAAAGAT GGAATCAGAA 2760

ACTACGTGGT GTGGAGGCTG TTGATGTTTC TGGTGTCAAG TTCTCAGAAG TTGCTGCCAC 2820

CAACTCTTTA AGAAGGCGAC AGGATCAGTC CTTCTCTAGG GTTCTGGCCC CCAAGGTCAG 2880

AGCAAGCATC TTCCTGACAG CATTTTGTCA TCTAAAGTCC AGTGACATGG TTCCCCGTGG 2940

TGGCCCGTGG CAGCCCGTGG CATGGCGTGG CTCAGCTGTC TGTTGAAGTT GTTGCAAGGA 3000

AAAGAGGAAA CATCTCGGGC CTAGTTCAAA CCTTTGCCTC AAAGCCATCC CCCACCAGAC 3060

TGCTTAGCGT CTGAGATCCG CGTGAAAAGT CCTCTGCCCA CGAGAGCAGG GAGTTGGGGC 3120

CACGCAGAAA TGGCCTCAAG GGGACTCTGC TCCACGTGGG GCCAGGCGTG TGACTGACGC 3180

TGTCCGACGA AGGCGGCCAC GGACGGACGC CAGCACACGA AGTCACGTGC AAGTGCCTTT 3240

GATTCGTTCC TTCTTTCTAA AGACGACAGT CTTTGTTGTT AGCACTGAAT TATTGAAAAT 3300

GTCAACCAGA TTCTAGAAAC TGCGGTCATC CAGTTCTTCC TGACACCGGA TGGGTGCTTG 3360

GGAACCGTTT GAGCCTTATA GATCATTTAC ATTCAATTTT TTTAACTCAG CAAGTGAGAA 3420

CTTACAAGAG GGTTTTTTTT TAATTTTTTT TTCTCTTAAT GAACACATTT TCTAAATGAA 3480

TTTTTTTTGT AGTTACTGTA TATGTACCAA GAAAGATATA ACGTTAGGGT TTGGTTGTTT 3540

TTGTTTTTGT ATTTTTTTTC TTTTGAAAGG GTTTGTTAAT TTTTCTAATT TTACCAAAGT 3600

TTGCAGCCTA TACCTCAATA AAACAGGGAT ATTTTAAATC ACATACCTGC AGACAAACTG 3660

GAGCAATGTT ATTTTTAAAG GGTTTTTTTC ACCTCCTTAT TCTTAGATTA TTAATGTATT 3720

AGGGAAGAAT GAGACAATTT TGTGTAGGCT TTTTCTAAAG TCCAGTACTT TGTCCAGATT 3780 TTAGATTCTC AGAATAAATG TTTTTCACAG ATTGAAAAAA AAAAAAAA

Seq ID NO: 455 Protein sequence Protein Accession ft: NP 037414.2

1 11 21 31 41 51

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MWIQVRTMDG RQTHTVDSLS RLTKVEELRR KIQELFHVEP GLQRLFYRGK QMEDGHTLFD 60 YEVRLNDTIQ LLVRQSLVLP HSTKERDSEL SDTDSGCCLG QSESDKSSTH GEAAAETDSR 120 PADEDMWDET ELGLYKVNEY VDARDTNMGA WFEAQWRVT RKAPSRDEPC SSTSRPALEE 180 D IYHVKYDD YPENGWQMN SRDVRARART IIKWQDLEVG QWMLNYNPD NPKERGFWYD 240 AEISRKRETR TARELYANW LGDDSLNDCR IIFVDEVFKI ERPGEGSPMV DNPMRRKSGP 300 SCKHCKDDVN RLCRVCACHL CGGRQDPDKQ LMCDECDMAF HIYCLDPPLS SVPSEDEWYC 360 PECRNDASEV VLAGERLRES KKKAKMASAT SSSQRDWGKG MACVGRTKEC TIVPSNHYGP 420 IPG1PVGTMW RFRVQVSESG VHRPHVAGIH GRSNDGAYSL VLAGGYEDDV DHGNFFTYTG 480 SGGRDLSGNK RTAEQSCDQK LTNTNRALAL NCFAPINDQE GAEAKDWRSG KPVRWRNVK 540 GGKNSKYAPA EGNRYDGIYK KYWPEKGK SGFLVWRYLL RRDDDEPGPW TKEGKDRIKK 600 LGLTMQYPEG YLEALANRER EKENSKREEE EQQEGGFASP RTGKGKWKRK SAGGGPSRAG 660 SPRRTSKKTK VEPYSLTAQQ SSLIREDKSN AKLWNEVLAS LKDRPASGSP FQLFLSKVEE 720 TFQCICCQEL VFRPITTVCQ HNVCKDCLDR SFRAQVFSCP ACRYDLGRSY AMQVNQPLQT

Seq ID NO: 456 DNA sequence

Nucleic Acid Accession ft: NM_001200.1

Coding sequence: 325..1514

11 31 51

GGGGACTTCT TGAACTTGCA GGGAGAATAA CTTGCGCACC CCACTTTGCG CCGGTGCCTT 60 TGCCCCAGCG GAGCCTGCTT CGCCATCTCC GAGCCCCACC GCCCCTCCAC TCCTCGGCCT 120 TGCCCGACAC TGAGACGCTG TTCCCAGCGT GAAAAGAGAG ACTGCGCGGC CGGCACCCGG 180 GAGAAGGAGG AGGCAAAGAA AAGGAACGGA CATTCGGTCC TTGCGCCAGG TCCTTTGACC 240 AGAGTTTTTC CATGTGGACG CTCTTTCAAT GGACGTGTCC CCGCGTGCTT CTTAGACGGA 300 CTGCGGTCTC CTAAAGGTCG ACCATGGTGβ CCGGGACCCG CTGTCTTCTA GCGTTGCTGC 360 TTCCCCAGGT CCTCCTGGGC GGCGCGGCTG GCCTCGTTCC GGAGCTGGGC CGCAGGAAGT 420 TCGCGGCGGC GTCGTCGGGC CGCCCCTCAT CCCAGCCCTC TGACGAGGTC CTGAGCGAGT 480 TCGAGTTGCG GCTGCTCAGC ATGTTCGGCC TGAAACAGAG ACCCACCCCC AGCAGGGACG 540 CCGTGGTGCC CCCCTACATG CTAGACCTGT ATCGCAGGCA CTCAGGTCAG CCGGGCTCAC 600 CCGCCCCAGA CCACCGGTTG GAGAGGGCAG CCAGCCGAGC CAACACTGTG CGCAGCTTCC 660 ACCATGAAGA ATCTTTGGAA GAACTACCAG AAACGAGTGG GAAAACAACC CGGAGATTCT 720 TCTTTAATTT AAGTTCTATC CCCACGGAGG AGTTTATCAC CTCAGCAGAG CTTCAGGTTT 780 TCCGAGAACA GATGCAAGAT GCTTTAGGAA ACAATAGCAG TTTCCATCAC CGAATTAATA 840 TTTATGAAAT CATAAAACCT GCAACAGCCA ACTCGAAATT CCCCGTGACC AGACTTTTGG 900 ACACCAGGTT GGTGAATCAG AATGCAAGCA GGTGGGAAAG TTTTGATGTC ACCCCCGCTG 960 TGATGCGGTG GACTGCACAG GGACACGCCA ACCATGGATT CGTGGTGGAA GTGGCCCACT 1020 TGGAGGAGAA ACAAGGTGTC TCCAAGAGAC ATGTTAGGAT AAGCAGGTCT TTGCACCAAG 1080 ATGAACACAG CTGGTCACAG ATAAGGCCAT TGCTAGTAAC TTTTGGCCAT GATGGAAAAG 1140 GGCATCCTCT CCACAAAAGA GAAAAACGTC AAGCCAAACA CAAACAGCGG AAACGCCTTA 1200 AGTCCAGCTG TAAGAGACAC CCTTTGTACG TGGACTTCAG TGACGTGGGG TGGAATGACT 1260 GGATTGTGGC TCCCCCGGGG TATCACGCCT TTTACTGCCA CGGAGAATGC CCTTTTCCTC 1320 TGGCTGATCA TCTGAACTCC ACTAATCATG CCATTGTTCA GACGTTGGTC AACTCTGTTA 1380 ACTCTAAGAT TCCTAAGGCA TGCTGTGTCC CGACAGAACT CAGTGCTATC TCGATGCTGT 1440 ACCTTGACGA GAATGAAAAG GTTGTATTAA AGAACTATCA GGACATGGTT GTGGAGGGTT 1500 GTGGGTGTCG CTAGTACAGC AAAATTAAAT ACATAAATAT ATATATA

Seq ID NO: 457 Protein sequence Protein Accession ft: NP 001191.1 11 21 31 41 51

MVAGTRCLLA LLLPQVLLGG AAGLVPELGR RKFAAASSGR PSSQPSDEVL SEFELRLLSM 60 FGLKQRPTPS RDAWPPYML DLYRRHSGQP GSPAPDHRLE RAASRANTVR SFHHEESLEE 120

LPETSGKTTR RFFFNLSSIP TEEFITSAEL QVFREQMQDA LGNNSSFHHR INIYEIIKPA 180 TANSKFPVTR LLDT Seq ID NO: 458 DNA sequence Nucleic Acid Accession ft : NM_001999.2

Coding sequence : 1. .8736

11 21 31 41 51

I I I I I

ATGGGGAGAA GACGGAGGCT GTGTCTCCAG CTCTACTTCC TGTGGCTGGG CTGTGTGGTG 60 CTCTGGGCGC AGGGCACGGC CGGCCAGCCT CAGCCTCCTC CGCCCAAGCC GCCCCGGCCC 120 CAGCCGCCGC CGCAACAGGT TCGGTCCGCT ACAGCAGGCT CTGAAGGCGG GTTTCTAGCG 180 CCCGAGTATC GCGAGGAGGG TGCCGCAGTG GCCAGCCGCG TCCGCCGGCG AGGACAGCAG 240 GACGTGCTCC GAGGGCCCAA CGTGTGCGGC TCCAGATTCC ACTCCTACTG CTGCCCTGGA 300 TGGAAGACGC TCCCTGGAGG AAACCAGTGC ATTGTCCCGA TTTGTAGAAA TAGTTGTGGA 360 GATGGATTTT GTTCCCGTCC TAACATGTGT ACTTGTTCCA GTGGGCAAAT ATCATCAACC 420 TGTGGATCAA AATCAATTCA GCAGTGCAGT GTGAGATGCA TGAATGGTGG GACCTGTGCA 480 GATGACCACT GCCAGTGCCA GAAAGGATAT ATTGGAACTT ATTGTGGACA ACCTGTCTGT 540 GAAAATGGAT GTCAGAATGG TGGACGTTGC ATCGCCCAAC CGTGTGCTTG TGTTTATGGG 600 TTCACTGGTC CACAGTGTGA AAGAGATTAC AGGACAGGCC CGTGTTTCAC TCAGGTCAAC 660 AACCAGATGT GCCAAGGGCA GCTGACAGGC ATTGTCTGCA CGAAGACTCT GTGCTGTGCC 720 ACCACTGGAC GGGCGTGGGG CCATCCCTGT GAGATGTGTC CAGCCCAGCC TCAGCCCTGC 780 CGACGGGGTT TCATCCCCAA CATCCGCACT GGAGCTTGCC AAGATGTTGA TGAATGCCAG 840 GCTATCCCAG GGATATGCCA AGGAGGAAAC TGTATCAATA CAGTGGGCTC TTTTGAATGC 900 AGATGCCCTG CTGGTCACAA ACAGAGTGAA ACTACTCAGA AATGTGAAGA CATTGATGAG 960 TGCAGCATCA TTCCTGGGAT ATGTGAAACT GGTGAATGTT CCAACACCGT GGGAAGCTAT 1020 TTTTGTGTTT GTCCACGTGG ATATGTAACC TCAACAGATG GCTCTCGATG CATCGATCAG 1080 AGAACAGGCA TGTGTTTCTC GGGCCTGGTG AATGGCCGCT GTGCACAAGA GCTCCCGGGG 1140 AGAATGACGA AAATGCAGTG CTGCTGTGAG CCTGGCCGCT GCTGGGGCAT CGGAACCATT 1200 CCTGAAGCCT GTCCTGTCAG AGGTTCTGAG GAATATCGCA GACTTTGCAT GGATGGACTT 1260 CCAATGGGAG GAATTCCAGG GAGTGCTGGT TCCAGACCTG GAGGCACTGG GGGAAATGGC 1320 TTTGCCCCAA GTGGCAATGG CAATGGCTAT GGCCCAGGAG GGACAGGCTT CATCCCCATC 1380 CCTGGAGGCA ATGGCTTTTC TCCTGGCGTT GGGGGAGCCG GTGTGGGGGC CGGGGGACAG 1440 GGACCTATCA TCACTGGACT AACAATTCTG AACCAGACAA TAGATATCTG TAAGCATCAT 1500 GCTAACCTTT GTTTAAATGG ACGCTGTATA CCAACTGTCT CAAGCTACCG ATGTGAATGC 1560 AACATGGGTT ATAAGCAGGA TGCAAATGGA GATTGTATAG ATGTTGATGA ATGCACATCA 1620 AATCCCTGCA CTAATGGAGA TTGTGTTAAC ACACCTGGTT CCTATTATTG TAAATGTCAT 1680 GCTGGATTCC AGAGGACTCC TACCAAGCAA GCATGCATTG ATATTGATGA GTGCATCCAG 1740 AATGGGGTTC TTTGTAAAAA CGGTCGATGC GTGAACTCAG ATGGAAGTTT CCAGTGCATT 1800 TGCAATGCCG GCTTTGAATT AACTACAGAT GGAAAAAACT GTGTTGATCA TGATGAATGT 1860 ACAACTACCA ACATGTGTTT GAATGGAATG TGCATCAATG AAGATGGCAG CTTCAAGTGC 1920 ATCTGCAAAC CAGGATTTGT CTTGGCTCCA AATGGGCGTT ACTGTACTGA TGTTGATGAA 1980 TGCCAGACCC CAGGAATCTG CATGAATGGG CACTGCATCA ACAGTGAAGG GTCCTTCCGC 2040 TGTGACTGTC CCCCAGGCCT GGCTGTGGGC ATGGATGGAC GTGTGTGTGT TGATACTCAC 2100 ATGCGCAGTA CCTGCTATGG AGGAATCAAG AAAGGAGTGT GTGTGCGTCC TTTCCCCGGT 2160 GCAGTGACCA AGTCCGAATG CTGCTGTGCC AATCCAGACT ATGGTTTTGG AGAACCCTGC 2220 CAGCCATGCC CTGCAAAAAA TTCAGCTGAA TTCCACGGCC TTTGTAGTAG TGGAGTAGGT 2280 ATCACTGTGG ATGGAAGAGA TATCAATGAA TGTGCTTTGG ATCCTGATAT ATGTGCCAAT 2340 GGGATTTGTG AAAACTTACG TGGTAGTTAC CGTTGTAATT GCAACAGTGG CTATGAACCA 2400 GATGCCTCTG GAAGAAACTG TATTGACATT GATGAATGTT TAGTAAACAG ACTGCTTTGT 2460 GATAACGGAT TGTGCCGAAA CACGCCAGGA AGTTACAGCT GTACGTGCCC ACCAGGGTAT 2520 GTGTTCAGGA CTGAGACAGA GACCTGTGAA GATATAAATG AATGTGAAAG CAACCCATGT 25B0 GTCAATGGGG CCTGCAGAAA CAACCTTGGA TCTTTCAATT GTGAATGTTC GCCCGGCAGC 2640 AAACTCAGCT CCACAGGATT GATCTGTATT GACAGCCTGA AGGGGACCTG TTGGCTCAAC 2700 ATCCAGGACA GCCGCTGTGA GGTGAATATT AATGGAGCCA CTCTGAAATC TGAATGCTGT 2760 GCCACCCTCG GAGCCGCCTG GGGGAGCCCC TGTGAGCGGT GTGAACTAGA TACAGCTTGC 2820 CCAAGAGGGC TTGCCAGGAT TAAAGGTGTT ACGTGTGAAG ATGTTAATGA GTGTGAGGTG 2880 TTCCCTGGCG TTTGTCCAAA TGGACGCTGT GTCAACAGTA AGGGATCTTT TCATTGCGAG 2940 TGCCCTGAAG GCCTTACGTT GGATGGGACT GGCCGTGTAT GTTTGGATAT TCGCATGGAG 3000 CAGTGTTACT TGAAGTGGGA TGAAGATGAA TGCATCCACC CCGTTCCTGG AAAGTTCCGC 3060 ATGGATGCCT GCTGCTGTGC TGTCGGGGCG GCTTGGGGCA CCGAGTGTGA GGAGTGCCCC 3120 AAACCTGGCA CCAAGGAATA CGAGACACTG TGCCCCCGCG GGGCTGGCTT TGCTAACCGA 3180 GGGGATGTTC TTACTGGGCG GCCATTTTAC AAAGACATCA ATGAATGGAA AGCATTTCCT 3240 GGGATGTGCA CTTATGGGAA GTGCAGAAAT ACAATCGGAA GCTTCAAATG CCGTTGCAAT 3300 AGTGGCTTTG CTCTAGACAT GGAGGAAAGA AACTGCACGG ACATCGACGA GTGCAGGATT 3360 TCTCCTGACC TCTGTGGCAG TGGAATCTGC GTCAATACAC CGGGCAGCTT TGAGTGCGAG 3420 TGCTTCGAAG GCTATGAAAG TGGCTTCATG ATGATGAAGA ACTGCATGGA CATTGACGGA 3480 TGTGAACGTA ACCCTCTCCT TTGTAGGGGT GGCACCTGTG TGAACACTGA GGGCAGCTTT 3540 CAGTGTGACT GCCCACTGGG ACACGAGCTG TCACCATCCC GTGAGGACTG TGTGGATATT 3600 AATGAATGCT CCCTGAGTGA CAATCTCTGC AGAAATGGAA AATGTGTGAA CATGATTGGA 3660 ACCTATCAGT GCTCTTGCAA TCCTGGATAT CAGGCTACGC CAGACCGCCA GGGCTGTACA 3720 GATATTGATG AATGTATGAT AATGAACGGA GGCTGTGACA CCCAGTGCAC AAATTCAGAG 3780 GGAAGCTACG AATGCAGCTG CAGTGAGGGT TATGCCCTGA TGCCAGATGG GAGATCGTGT 3840 GCAGACATTG ATGAATGTGA AAACAATCCT GATATCTGTG ATGGCGGCCA GTGTACCAAC 3900 ATTCCTGGAG AGTATCGCTG CCTCTGCTAT GATGGCTTCA TGGCTTCCAT GGACATGAAA 3960 ACATGCATTG ATGTCAATGA ATGTGACCTA AATTCAAATA TCTGCATGTT TGGGGAATGT 4020 GAGAACACAA AGGGATCCTT CATTTGCCAC TGTCAGCTGG GTTACTCAGT GAAGAAGGGG 4080 ACCACAGGAT GTACAGATGT GGATGAGTGT GAAATTGGTG CTCATAACTG CGACATGCAT 4140 GCCTCATGTC TGAATATCCC AGGAAGCTTC AAGTGTAGCT GCAGAGAAGG CTGGATTGGA 4200 AACGGCATCA AGTGTATTGA TCTGGACGAA TGTTCTAATG GAACCCACCA GTGTAGCATC 4260 AATGCTCAGT GTGTAAATAC CCCGGGCTCA TACCGCTGTG CCTGCTCCGA AGGTTTCACT 4320 GGTGATGGCT TTACCTGCTC AGATGTTGAT GAGTGTGCAG AAAACATAAA GCTCTGTGAG 4380 AACGGACAGT GCCTTAATGT CCCGGGTGCA TATCGCTGCG AGTGTGAGAT GGGCTTCACT 4440

CCAGCCTCAG ACAGCAGATC CTGCCAAGAT ATTGATGAAT GCTCCTTCCA AAACATTTGT 4500

GTCTCTGGAA CATGTAATAA CCTGCCTGGA ATGTTTCATT GCATCTGCGA TGATGGTTAT 4560

GAATTGGACA GAACAGGAGG GAACTGTACA GATATTGATG AGTGTGCAGA TCCTATAAAC 4620

TGTGTCAATG GCCTATGTGT CAACACGCCT GGTCGCTATG AGTGTAACTG CCCACCCGAT 4680

TTTCAGTTGA ACCCAACTGG TGTGGGTTGT GTTGACAACC GTGTGGGCAA CTGCTACCTG 4740

AAGTTTGGAC CTCGAGGAGA TGGGAGTCTG TCTTGCAACA CCGAGATCGG GGTGGGCGTC 4800

AGTCGCTCTT CATGCTGCTG CTCTCTGGGA AAGGCCTGGQ GAAACCCCTG TGAGACATGC 4860

CCCCCTGTCA ATAGCACTGA ATATTACACC CTGTGTCCCG GAGGTGAAGG CTTCAGACCT 4920

AACCCCATCA CAATCATTTT AGAAGACATT GACGAATGCC AGGAGTTACC AGGTCTCTGC 4980

CAGGGTGGAA ACTGCATCAA CACTTTTGGG AGCTTCCAGT GTGAGTGCCC ACAAGGCTAC 5040

TACCTCAGCG AGGATACCCG CATCTGTGAG GATATTGATG AGTGTTTTGC ACATCCTGGT 5100

GTGTGTGGGC CTGGGACCTG CTATAACACC CTGGGAAATT ACACCTGCAT TTGCCCACCT 5160

GAGTACATGC AGGTCAATGG AGGCCACAAC TGCATGGACA TGAGAAAAAG CTTTTGCTAC 5220

CGAAGCTATA ATGGAACCAC TTGTGAGAAT GAGTTGCCTT TCAATGTGAC AAAAAGGATG 5280

TGCTGCTGCA CATATAATGT GGGCAAAGCT GGGAACAAAC CTTGTGAACC ATGCCCAACT 5340

CCAGGAACAG CTGACTTTAA AACCATATGT GGAAATATTC CTGGATTCAC CTTTGACATT 5400

CACACAGGAA AAGCTGTTGA CATTGATGAA TGTAAAGAGA TTCCAGGCAT TTGTGCAAAT 5460

GGTGTGTGCA TTAACCAGAT TGGCAGTTTC CGCTGTGAAT GCCCTACAGG ATTCAGTTAC 5520

AATGACCTGC TGTTGGTTTG TGAAGATATA GATGAGTGCA GCAATGGTGA TAATCTCTGC 5580

CAGCGGAATG CAGACTGCAT CAATAGTCCT GGTAGTTACC GCTGTGAATG TGCCGCGGGT 5640

TTCAAACTTT CACCCAATGG GGCCTGTGTA GATCGCAATG AATGTTTAGA AATTCCTAAC 5700

GTTTGCAGTC ATGGCTTGTG TGTTGATCTG CAAGGAAGTT ACCAGTGCAT CTGCCACAAT 5760

GGCTTTAAGG CTTCTCAGGA CCAGACCATG TGCATGGATG TTGATGAGTG CGAGCGGCAC 5820

CCATGTGGAA ATGGAACTTG TAAAAACACC GTTGGATCCT ATAACTGTCT GTGCTACCCA 5880

GGGTTTGAAC TCACTCATAA TAATGATTGC CTGGACATAG ATGAGTGCAG TTCCTTTTTT 5940

GGTCAGGTGT GCAGAAATGG ACGTTGTTTT AATGAAATTG GTTCTTTCAA GTGTCTATGT 6000

AACGAAGGTT ATGAACTTAC CCCAGATGGC AAAAACTGTA TAGACACTAA TGAGTGTGTC 6060

GCCCTTCCCG GCTCTTGCTC TCCTGGTACC TGTCAGAATT TGGAGGGATC CTTCAGATGC 6120

ATCTGTCCCC CAGGGTATGA AGTAAAAAGC GAGAACTGCA TTGATATAAA TGAATGTGAT 6180

GAAGATCCCA ACATTTGTCT TTTTGGTTCC TGTACTAATA CTCCAGGGGG CTTCCAGTGC 6240

CTCTGCCCCC CTGGCTTTGT ACTATCTGAT AATGGACGGA GATGCTTTGA TACTCGCCAG 6300

AGCTTCTGCT TCACAAATTT TGAAAATGGA AAGTGTTCTG TACCCAAAGC TTTCAACACC 6360

ACAAAAGCAA AATGCTGCTG TAGTAAGATG CCAGGAGAGG GCTGGGGGGA CCCCTGTGAG 6420

CTGTGCCCCA AAGACGATGA AGTTGCATTT CAGGATTTGT GTCCATATGG CCATGGAACT 6480

GTCCCTAGTC TTCATGATAC ACGTGAAGAT GTCAATGAGT GTCTTGAGAG CCCAGGCATT 6540

TGTTCAAATG GTCAATGTAT CAACACCGAC GGATCTTTTC GCTGTGAATG TCCAATGGGC 6600

TACAACCTTG ACTACACTGG AGTACGCTGT GTGGATACTG ATGAGTGTTC AATCGGCAAT 6660

CCGTGTGGAA ATGGTACATG CACCAATGTT ATTGGGAGTT TTGAATGCAA TTGCAATGAA 6720

GGCTTTGAGC CAGGGCCCAT GATGAATTGT GAAGATATCA ACGAATGTGC CCAGAACCCA 6780

CTGCTGTGTG CTTTACGCTG CATGAACACT TTTGGGTCCT ATGAATGCAC GTGCCCGATT 6840

GGCTATGCCC TCAGGGAAGA TCAAAAGATG TGCAAAGATC TGGATGAATG TGCTGAAGGG 6900

TTACACGACT GTGAATCTAG GGGCATGATG TGTAAGAATC TAATCGGCAC CTTCATGTGC 6960

ATCTGCCCTC CTGGAATGGC CCGAAGGCCC GATGGAGAAG GCTGTGTAGA TGAAAATGAA 7020

TGCAGGACCA AGCCAGGAAT CTGTGAAAAT GGACGTTGTG TTAACATTAT TGGAAGCTAT 7080

AGATGTGAGT GTAATGAAGG ATTCCAGTCA AGTTCTTCAG GCACTGAATG CCTTGACAAT 7140

CGACAGGGTC TCTGCTTTGC AGAGGTACTG CAGACAATAT GTCAAATGGC ATCCAGTAGT 7200

CGCAATCTCG TCACTAAGTC AGAATGCTGC TGTGATGGTG GGCGAGGCTG GGGCCACCAG 7260

TGCGAGCTTT GCCCACTTCC TGGAACTGCC CAGTACAAAA AGATATGTCC TCATGGCCCA 7320

GGATATACAA CTGATGGAAG AGATATTGAT GAATGTAAGG TAATGCCAAA CCTCTGCACC 7380

AATGGTCAGT GCATCAATAC CATGGGCTCA TTCCGATGCT TCTGCAAGGT TGGCTACACC 7440

ACAGACATCA GTGGAACCTC TTGTATAGAC. CTTGATGAAT GCTCCCAGTC CCCGAAACCA 7500

TGCAACTACA TCTGCAAGAA CACTGAGGGG AGTTATCAGT GTTCATGTCC GAGGGGGTAT 7560

GTCCTGCAAG AGGATGGAAA GACATGCAAA GACCTTGATG AATGTCAAAC AAAGCAGCAT 7620

AACTGCCAGT TCCTCTGTGT CAACACCCTG GGGGGGTTTA CCTGTAAATG TCCACCTGGT 7680

TTCACACAGC ATCACACTGC TTGTATCGAC AACAACGAAT GTGGGTCTCA ACCTTTGCTT 7740

TGTGGAGGAA AGGGAATCTG TCAAAACACT CCAGGCAGTT TCAGCTGTGA ATGCCAAAGA 7800

GGGTTCTCTC TTGATGCCAC CGGACTGAAC TGTGAAGATG TTGATGAATG TGATGGGAAC 7860

CACAGGTGCC AACACGGCTG CCAGAACATC CTGGGTGGCT ACAGATGTGG CTGCCCCCAA 7920

GGCTACATCC AGCACTACCA GTGGAATCAG TGTGTCGATG AGAATGAATG CTCCAATCCC 79B0

AATGCCTGTG GCTCTGCTTC CTGCTACAAC ACCCTGGGGA GTTACAAGTG CGCCTGCCCC 8040

TCGGGGTTCT CCTTCGACCA GTTCTCCAGT GCCTGCCACG ACGTGAATGA GTGCTCGTCC 8100

TCCAAGAACC CCTGCAATTA CGGCTGCTCT AACACGGAGG GGGGCTACCT CTGTGGCTGC 8160

CCCCCTGGGT ATTACAGAGT GGGACAAGGC CACTGTGTCT CAGGAATGGG ATTTAACAAG 8220

GGGCAGTACC TGTCACTGGA TACAGAGGTC GATGAGGAAA ATGCTCTGTC CCCAGAAGCA 8280

TGCTACGAGT GCAAAATCAA CGGCTATCCT AAGAAAGACA GCAGGCAGAA GAGAAGTATT 8340

CATGAACCTG ATCCCACTGC TGTTGAACAG ATCAGCCTAG AGAGTGTCGA CATGGACAGC 8400

CCCGTCAACA TGAAGTTCAA CCTCTCCCAC CTCGGCTCTA AGGAGCACAT CCTGGAACTA 8460

AGGCCCGCCA TCCAGCCCCT CAACAACCAC ATCCGTTATG TCATCTCTCA AGGGAACGAT 8520

GACAGCGTCT TCCGCATCCA CCAAAGGAAT GGGCTCAGCT ACTTGCACAC GGCCAAGAAG 8580

AAGCTCATGC CCGGCACATA CACACTGGAA ATCACTAGCA TCCCTCTCTA CAAGAAGAAG 8640

GAGCTTAAGA AACTGGAAGA GAGCAATGAG GATGACTACC TCCTAGGGGA GCTTGGGGAG 8700

GCTCTCAGAA TGAGGCTGCA GATTCAGCTC TATTAACCGT TCACAGACTT GGGCCCAGGC 8760

TCAAATCCTA GCACAGCCAG TCTGCAGAAG CATTTGAAAA GTCAAGGACT AATTTTAAAG 8820

AGGAAAAATA ATAATAACTC TTGTTTCTTT CCTCCCTGTC TTAGACTTTG AATGTTGACC 8880

CTCACAGGGA GGGATAATTT AGACTCTGGT ATGGCCAAAG ATTTGAGCTC AAAGGCAACC 8940

GTGGTTACTG TATTTTTTAT ATAACTTCAT TTTAAAATAT ATTAAAAGAA ACCTAAATGT 9000

TCAAGATATC AGCATATGGC ACTAAATGCA CAAAAATAAT GTGAGCTTTT TTTTTTTTTT 9060

CCTGTTAGCA GTCTGTAACA CTTTGGGTAT TTTGCTATAG TTGCTAATTA AAAAAATATA 9120

GATGTTTATT TATTTTTAAT GCAGTAATAT ATGGAGAAAT GAACAAACTA TGTAAACAAA 9180

AAGGGAAACT CACTTGTTTT TCTTTAGATT TATAAATTTG AGCTATTTTT TTTAGAGGTG 9240

CTTTTTAAAA ATCCAATAGA TACAAGAGAT GTTTCCTTTG GTTTTCTGCC AGTCATCCAG 9300

CTGATACACA CCTGATCGAT TTTAAAGAAA GCCACACAGA GCTGAATCGG GCAGTGCTAA 9360

TCAATAATTT AAAAGACATG AATGTCATTA GATCCTTTAT AACGTAGATC GAAGCCAAAG 9420

CAGCTCATTT GTGACAACAT TTCATATCAC CAGACACACC AGGCAACAGA AGTTGAAGCA 9480

CAACCACTGT AGCAAAATAC CTTGACTGCT TGTGAGACCA TTAGCATTGC AGGCCAAACC 9540

GTACTGTATT TCCTTCTCAT AACCTCAAGG AACCATATGT GCTACCCACA ACACCTCATT 9600 CTTACCCAGG GTGCGCTGCG TCCTCATGGT ACTGTAGGCA GCTGAAGAAC CGCCGTTCCC 9660

TTGAAAGGGA ACACCTGGCA TTCTGTGGTG TTTCGTGCTG TCTTAAATAA TGGTGCATTT 9720

ATTATGTTCA AGTTATTTCA GGATTGCCAT ATGTGCAAAC AAATCATGCA ATGCAGCCAA 9780

GGAATATATG TTGTTGTTGT TGTTTTAAAC CCATTTTTTT TTTAGAATTT TCATTAATAC 9840

TGTAGTTATA CACCATATGC CTCATTTTAT CATAGCCTAT TGTGTATGAA AGATGTTTGT 9900

ACAATGAATT GATGTTTAGT TTGCTTTAGT CATTTAAAAA GATATTGTAC CAGGATGTGC 9960

TATTAAGAGC ACGTATCCAT TATTCTTCTC AACCCAAGAA CCTGTTTCCT GGACCAGTGA 10020

CCAAACCTCA TATGTGAAAT GGCCAAAGCA CATGCAGGCT CCTGGTTGTT CCTCTCAAAC 10080

CTGTGCTGAC CAAAGATTAG TAACCAGTTA TACCCAGTAT TTTGAGGTTT TATTGTTTTT 10140 TTAATAACTA AAAAAAAACT CGTGCC

Seq ID NO: 459 Protein sequence Protein Accession ft: NP 001990.1

11 21 31 41 51

MGRRRRLCLQ LYFLWLGCW LWAQGTAGQP QPPPPKPPRP QPPPQQVRSA TAGSEGGFLA 60 PEYREEGAAV ASRVRRRGQQ DVLRGPNVCG SRFHSYCCPG WKTLPGGNQC IVPICRNSCG 120 DGFCSRPNMC TCSSGQISST CGSKSIQQCS VRCMNGGTCA DDHCQCQKGY IGTYCGQPVC 180 ENGCQNGGRC IAQPCACVYG FTGPQCERDY RTGPCFTQVN NQMCQGQLTG IVCTKTLCCA 240 TTGRAWGHPC EMCPAQPQPC RRGFIPNIRT GACQDVDECQ AIPGICQGGN CINTVGSFEC 300 RCPAGHKQSE TTQKCEDIDE CSIIPGICET GECSNTVGSY FCVCPRGYVT STDGSRCIDQ 360 RTGMCFSGLV NGRCAQELPG RMTKMQCCCE PGRCWGIGTI PEACPVRGSE EYRRLCMDGL 420 PMGGIPGSAG SRPGGTGGNG FAPSGNGNGY GPGGTGFIPI PGGNGFSPGV GGAGVGAGGQ 480 GPIITGLTIL NQTIDICKHH ANLCLNGRCI PTVSSYRCEC NMGYKQDANG DCIDVDECTS 540 NPCTNGDCVN TPGSYYCKCH AGFQRTPTKQ ACIDIDECIQ NGVLCKNGRC VNSDGSFQCI 600 CNAGFELTTD GKNCVDHDEC TTTNMCLNGM CINEDGSFKC ICKPGFVLAP NGRYCTDVDE 660 CQTPGICMNG HCINSEGSFR CDCPPGLAVG MDGRVCVDTH MRSTCYGGIK KGVCVRPFPG 720 AVTKSECCCA NPDYGFGEPC QPCPAKNSAE FHGLCSSGVG ITVDGRDINE CALDPDICAN 780 GICENLRGSY RCNCNSGYEP DASGRNCIDI DECLVNRLLC DNGLCRNTPG SYSCTCPPGY 840 VFRTETETCE DINECESNPC VNGACRNNLG SFNCECSPGS KLSSTGLICI DSLKGTCWLN 900 IQDSRCEVNI NGATLKSECC ATLGAAWGSP CERCELDTAC PRGLARIKGV TCEDVNECEV 960 FPGVCPNGRC VNSKGSFHCE CPEGLTLDGT GRVCLDIRME QCYLKWDEDE CIHPVPGKFR 1020 MDACCCAVGA AWGTECEECP KPGTKEYETL CPRGAGFANR GDVLTGRPFY KDINECKAFP 1080 GMCTYGKCRN TIGSFKCRCN SGFALDMEER NCTDIDECRI SPDLCGSGIC VNTPGSFECE 1140 CFEGYESGFM MMKNCMDIDG CERNPLLCRG GTCVNTEGSF QCDCPLGHEL SPSREDCVDI 1200 NECSLSDNLC RNGKCVNMIG TYQCSCNPGY QATPDRQGCT DIDECMIMNG GCDTQCTNSE 1260 GSYECSCSEG YALMPDGRSC ADIDECENNP DICDGGQCTN IPGEYRCLCY DGFMASMDMK 1320 TCIDVNECDL NSNICMFGEC ENTKGSFICH CQLGYSVKKG TTGCTDVDEC EIGAHNCDMH 1380 ASCLNIPGSF KCSCREGWIG NGIKCIDLDE CSNGTHQCSI NAQCVNTPGS YRCACSEGFT 1440 GDGFTCSDVD ECAENINLCE NGQCLNVEGA YRCECEMGFT PASDSRSCQD IDECSFQNIC 1500 VSGTCNNLPG MFHCICDDGY ELDRTGGNCT DIDECADPIN CVNGLCVNTP GRYECNCPPD 1560 FQLNPTGVGC VDNRVGNCYL KFGPRGDGSL SCNTEIGVGV SRSSCCCSLG KAWGNPCETC 1620 PPVNSTEYYT LCPGGEGFRP NPITIILEDI DECQELPGLC QGGNCINTFG SFQCECPQGY 1680 YLSEDTRICE DIDECFAHPG VCGPGTCYNT LGNYTCICPP EYMQVNGGHN CMDMRKSFCY 1740 RSYNGTTCEN ELPFNVTKRM CCCTYNVGKA GNKPCEPCPT PGTADFKTIC GNIPGFTFDI 1800 HTGKAVDIDE CKEIPGICAN GVCINQIGSF RCECPTGFSY NDLLLVCEDI DECSNGDNLC 1860 QRNADCINSP GSYRCECAAG FKLSPNGACV DRNECLEIPN VCSHGLCVDL QGSYQCICHN 1920 GFKASQDQTM CMDVDECERH PCGNGTCKNT VGSYNCLCYP GFELTHNNDC LDIDECSSFF 1980 GQVCRNGRCF NEIGSFKCLC NEGYELTPDG KNCIDTNECV ALPGSCSPGT CQNLEGSFRC 2040 ICPPGYEVKS ENCIDINECD EDPNICLFGS CTNTPGGFQC LCPPGFVLSD NGRRCFDTRQ 2100 SFCFTNFENG KCSVPKAFNT TKAKCCCSKM PGEGWGDPCE LCPKDDEVAF QDLCPYGHGT 2160 VPSLHDTRED VNECLESPGI CSNGQCINTD GSFRCECPMG YNLDYTGVRC VDTDECSIGN 2220 PCGNGTCTNV IGSFECNCNE GFEPGPMMNC EDINECAQNP LLCALRCMNT FGSYECTCPI 2280 GYALREDQKM CKDLDECAEG LHDCESRGMM CKNLIGTFMC ICPPGMARRP DGEGCVDENE 2340 CRTKPGICEN GRCVNIIGSY RCECNEGFQS SSSGTECLDN RQGLCFAEVL QTICQMASSS 2400 RNLVTKSECC CDGGRGWGHQ CELCPLPGTA QYKKICPHGP GYTTDGRDID ECKVMPNLCT 2460 NGQCINTMGS FRCFCKVGYT TDISGTSCID LDECSQSPKP CNYICKNTEG SYQCSCPRGY 2520 VLQEDGKTCK DLDECQTKQH NCQFLCVNTL GGFTCKCPPG FTQHHTACID NNECGSQPLL 2580 CGGKGICQNT PGSFSCECQR GFSLDATGLN CEDVDECDGN HRCQHGCQNI LGGYRCGCPQ 2640 GYIQHYQWNQ CVDENECSNP NACGSASCYN TLGSYKCACP SGFSFDQFSS ACHDVNECSS 2700 SKNPCNYGCS NTEGGYLCGC PPGYYRVGQG HCVSGMGFNK GQYLSLDTEV DEENALSPEA 2760 CYECKINGYP KKDSRQKRSI HEPDPTAVEQ ISLESVDMDS PVNMKFNLSH LGSKEHILEL 2820 RPAIQPLNNH IRYVISQGND DSVFRIHQRN GLSYLHTAKK KLMPGTYTLE ITSIPLYKKK 2B80 ELKKLEESNE DDYLLGELGE ALRMRLQIQL Y

Seq ID NO: 460 DNA sequence

Nucleic Acid Accession ft: NM_013372.1

Coding sequence: 63..617

11 21 31 41 51

GCGGCCGCAC TCAGCGCCAC GCGTCGAAAG CGCAGGCCCC GAGGACCCGC CGCACTGACA 60 GTATGAGCCG CACAGCCTAC ACGGTGGGAG CCCTGCTTCT CCTCTTGGGG ACCCTGCTGC 120 CGGCTGCTGA AGGGAAAAAG AAAGGGTCCC AAGGTGCCAT CCCCCCGCCA GACAAGGCCC 180 AGCACAATGA CTCAGAGCAG ACTCAGTCGC CCCAGCAGCC TGGCTCCAGG AACCGGGGGC 240 GGGGCCAAGG GCGGGGCACT GCCATGCCCG GGGAGGAGGT GCTGGAGTCC AGCCAAGAGG 300 CCCTGCATGT GACGGAGCGC AAATACCTGA AGCGAGACTG GTGCAAAACC CAGCCGCTTA 360 AGCAGACCAT CCACGAGGAA GGCTGCAACA GTCGCACCAT CATCAACCGC TTCTGTTACG 420 GCCAGTGCAA CTCTTTCTAC ATCCCCAGGC ACATCCGGAA GGAGGAAGGT TCCTTTCAGT 480 CCTGCTCCTT CTGCAAGCCC AAGAAATTCA CTACCATGAT GGTCACACTC AACTGCCCTG 540 AACTACAGCC ACCTACCAAG AAGAAGAGAG TCACACGTGT GAAGCAGTGT CGTTGCATAT 600 CCATCGATTT GGATTAAGCC AAATCCAGGT GCACCCAGCA TGTCCTAGGA ATGCAGCCCC 660 AGGAAGTCCC AGACCTAAAA CAACCAGATT CTTACTTGGC TTAAACCTAG AGGCCAGAAG 720 AACCCCCAGC TGCCTCCTGG CAGGAGCCTG CTTGTGCGTA GTTCGTGTGC ATGAGTGTGG 780 ATGGGTGCCT GTGGGTGTTT TTAGACACCA GAGAAAACAC AGTCTCTGCT AGAGAGCACT 840 CCCTATTTTG TAAACATATC TGCTTTAATG GGGATGTACC AGAAACCCAC CTCACCCCGG 900 CTCACATCTA AAGGGGCGGG GCCGTGGTCT GGTTCTGACT TTGTGTTTTT GTGCCCTCCT 960

GGGGACCAGA ATCTCCTTTC GGAATGAATG TTCATGGAAG AGGCTCCTCT GAGGGCAAGA 1020

GACCTGTTTT AGTGCTGCAT TCGACATGGA AAAGTCCTTT TAACCTGTGC TTGCATCCTC 1080

CTTTCCTCCT CCTCCTCACA ATCCATCTCT TCTTAAGTTG ATAGTGACTA TGTCAGTCTA 1140

ATCTCTTGTT TGCCAAGGTT CCTAAATTAA TTCACTTAAC CATGATGCAA ATGTTTTTCA 1200

TTTTGTGAAG ACCCTCCAGA CTCTGGGAGA GGCTGGTGTG GGCAAGGACA AGCAGGATAG 1260

TGGAGTGAGA AAGGGAGGGT GGAGGGTGAG GCCAAATCAG GTCCAGCAAA AGTCAGTAGG 1320

GACATTGCAG AAGCTTGAAA GGCCAATACC AGAACACAGG CTGATGCTTC TGAGAAAGTC 1380

TTTTCCTAGT ATTTAACAGA ACCCAAGTGA ACAGAGGAGA AATGAGATTG CCAGAAAGTG 1440

ATTAACTTTG GCCGTTGCAA TCTGCTCAAA CCTAACACCA AACTGAAAAC ATAAATACTG 1500

ACCACTCCTA TGTTCGGACC CAAGCAAGTT AGCTAAACCA AACCAACTCC TCTGCTTTGT 1560

CCCTCAGGTG GAAAAGAGAG GTAGTTTAGA ACTCTCTGCA TAGGGGTGGG AATTAATCAA 1620

AAACCKCAGA GGCTGAAATT CCTAATACCT TTCCTTTATC GTGGTTATAG TCAGCTCATT 1680

TCCATTCCAC TATTTCCCAT AATGCTTCTG AGAGCCACTA ACTTGATTGA TAAAGATCCT 1740

GCCTCTGCTG AGTGTACCTG ACAGTAAGTC TAAAGATGAR AGAGTTTAGG GACTACTCTG 1800

TTTTAGCAAG ARATATTKTG GGGGTCTTTT TGTTTTAACT ATTGTCAGGA GATTGGGCTA 1860

RAGAGAAGAC GACGAGAGTA AGGAAATAAA GGGRATTGCC TCTGGCTAGA GAGTAAGTTA 1920

GGTGTTAATA CCTGGTAGAA ATGTAAGGGA TATGACCTCC CTTTCTTTAT GTGCTCACTG 1980

AGGATCTGAG GGGACCCTGT TAGGAGAGCA TAGCATCATG ATGTATTAGC TGTTCATCTG 2040

CTACTGGTTG GATGGACATA ACTATTGTAA CTATTCAGTA TTTACTGGTA GGCACTGTCC 2100

TCTGATTAAA CTTGGCCTAC TGGCAATGGC TACTTAGGAT TGATCTAAGG GCCAAAGTGC 2160

AGGGTGGGTG AACTTTATTG TACTTTGGAT TTGGTTAACC TGTTTTCTTC AAGCCTGAGG 2220

TTTTATATAC AAACTCCCTG AATACTCTTT TTGCCTTGTA TCTTCTCAGC CTCCTAGCCA 2280

AGTCCTATGT AATATGGAAA ACAAACACTG CAGACTTGAG ATTCAGTTGC CGATCAAGGC 2340

TCTGGCATTC AGAGAACCCT TGCAACTCGA GAAGCTGTTT TTATTTCGTT TTTGTTTTGA 2400

TCCAGTGCTC TCCCATCTAA CAACTAAACA GGAGCCATTT CAAGGCGGGA GATATTTTAA 2460

ACACCCAAAA TGTTGGGTCT GATTTTCAAA CTTTTAAACT CACTACTGAT GATTCTCACG 2520

CTAGGCGAAT TTGTCCAAAC ACATAGTGTG TGTGTTTTGT ATACACTGTA TGACCCCACC 2580

CCAAATCTTT GTATTGTCCA CATTCTCCAA CAATAAAGCA CAGAGTGGAT TTAATTAAGC 2640

ACACAAATGC TAAGGCAGAA TTTTGAGGGT GGGAGAGAAG AAAAGGGAAA GAAGCTGAAA 2700

ATGTAAAACC ACACCAGGGA GGAAAAATGA CATTCAGAAC CAGCAAACAC TGAATTTCTC 2760

TTGTTGTTTT AACTCTGCCA CAAGAATGCA ATTTCGTTAA TGGAGATGAC TTAAGTTGGC 2820

AGCAGTAATC TTCTTTTAGG AGCTTGTACC ACAGTCTTGC ACATAAGTGC AGATTTGGCT 2880

CAAGTAAAGA GAATTTCCTC AACACTAACT TCACTGGGAT AATCAGCAGC GTAACTACCC 2940

TAAAAGCATA TCACTAGCCA AAGAGGGAAA TATCTGTTCT TCTTACTGTG CCTATATTAA 3000

GACTAGTACA AATGTGGTGT GTCTTCCAAC TTTCATTGAA AATGCCATAT CTATACCATA 3060

TTTTATTCGA GTCACTGATG ATGTAATGAT ATATTTTTTC ATTATTATAG TAGAATATTT 3120

TTATGGCAAG ATATTTGTGG TCTTGATCAT ACCTATTAAA ATAATGCCAA ACACCAAATA 3180

TGAATTTTAT GATGTACACT TTGTGCTTGG CATTAAAAGA AAAAAACACA CATCCTGGAA 3240

GTCTGTAAGT TGTTTTTTGT TACTGTAGGT CTTCAAAGTT AAGAGTGTAA GTGAAAAATC 3300

TGGAGGAGAG GATAATTTCC ACTGTGTGGA ATGTGAATAG TTAAATGAAA AGTTATGGTT 3360

ATTTAATGTA ATTATTACTT CAAATCCTTT GGTCACTGTG ATTTCAAGCA TGTTTTCTTT 3420

TTCTCCTTTA TATGACTTTC TCTGAGTTGG GCAAAGAAGA AGCTGACACA CCGTATGTTG 3480

TTAGAGTCTT TTATCTGGTC AGGGGAAACA AAATCTTGAC CCAGCTGAAC ATGTCTTCCT 3540

GAGTCAGTGC CTGAATCTTT ATTTTTTAAA TTGAATGTTC CTTAAAGGTT AACATTTCTA 3600

AAGCAATATT AAGAAAGACT TTAAATGTTA TTTTGGAAGA CTTACGATGC ATGTATACAA 3660

ACGAATAGCA GATAATGATG ACTAGTTCAC ACATAAAGTC CTTTTAAGGA GAAAATCTAA 3720

AATGAAAAGT GGATAAACAG AACATTTATA AGTGATCAGT TAATGCCTAA GAGTGAAAGT 3780

AGTTCTATTG ACATTCCTCA AGATATTTAA TATCAACTGC ATTATGTATT ATGTCTGCTT 3840

AAATCATTTA AAAACGGCAA AGAATTATAT AGACTATGAG GTACCTTGCT GTGTAGGAGG 3900

ATGAAAGGGG AGTTGATAGT CTCATAAAAC TAATTTGGCT TCAAGTTTCA TGAATCTGTA 3960

ACTAGAATTT AATTTTCACC CCAATAATGT TCTATATAGC CTTTGCTAAA GAGCAACTAA 4020 TAAATTAAAC CTATTCTTTC AAAAAAAAA

Seq ID NO: 461 Protein sequence Protein Accession ft: NP 037504.1

1 11 21 31 41 51

I I I I I I

MSRTAYTVGA LLLLLGTLLP AAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP QQPGSRNRGR 60 GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK QTIHEEGCNS RTIINRFCYG 120 QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS 180 IDLD

Seq ID NO: 462 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 1..2733

11 21 31 41

ATGAAAGTTG GAGTGCTGTG GCTCATTTCT TTCTTCACCT TCACTGACGG CCACGGTGGC 60

TTCCTGGGGA AAAATGATGG CATCAAAACA AAAAAAGAAC TCATTGTGAA TAAGAAAAAA 120

CATCTAGGCC CAGTCGAAGA ATATCAGCTG CTGCTTCAGG TGACCTATAG AGATTCCAAG 180

GAGAAAAGAG ATTTGAGAAA TTTTCTGAAG CTCTTGAAGC CTCCATTATT ATGGTCACAT 240

GGGCTAATTA GAATTATCAG AGCAAAGGCT ACCACAGACT GCAACAGCCT GAATGGAGTC 300

CTGCAGTGTA CCTGTGAAGA CAGCTACACC TGGTTTCCTC CCTCATGCCT TGATCCCCAG 360

AACTGCTACC TTCACACGGC TGGAGCACTC CCAAGCTGTG AATGTCATCT CAACAACCTC 420

AGCCAGAGTG TCAATTTCTG TGAGAGAACA AAGATTTGGG GCACTTTCAA AATTAATGAA 480

AGGTTTACAA ATGACCTTTT GAATTCATCT TCTGCTATAT ACTCCAAATA TGCAAATGGA 540

ATTGAAATTC AACTTAAAAA AGCATATGAA AGAATTCAAG GTTTTGAGTC GGTTCAGGTC 600

ACCCAATTTC GAAATGGAAG CATCGTTGCT GGGTATGAAG TTGTTGGCTC CAGCAGTGCA 660

TCTGAACTGC TGTCAGCCAT TGAACATGTT GCCGAGAAGG CTAAGACAGC CCTTCACAAG 720

CTGTTTCCAT TAGAAGACGG CTCTTTCAGA GTGTTCGGAA AAGCCCAGTG TAATGACATT 780

GTCTTTGGAT TTGGGTCCAA GGATGATGAA TATACCCTGC CCTGCAGCAG TGGCTACAGG 840

GGAAACATCA CAGCCAAGTG TGAGTCCTCT GGGTGGCAGG TCATCAGGGA GACTTGTGTG 900

CTCTCTCTGC TTGAAGAACT GAACAAGAAT TTCAGTATGA TTGTAGGCAA TGCCACTGAG 960

GCAGCTGTGT CATCCTTCGT GCAAAATCTT TCTGTCATCA TTCGGCAAAA CCCATCAACC 1020 ACAGTGGGGA ATCTGGCTTC GGTGGTGTCG ATTCTGAGCA ATATTTCATC TCTGTCACTG 1080

GCCAGCCATT TCAGGGTGTC CAATTCAACA ATGGAGGATG TCATCAGTAT AGCTGACAAT 1140

ATCCTTAATT CAGCCTCAGT AACCAACTGG ACAGTCTTAC TGCGGGAAGA AAAGTATGCC 1200

AGCTCACGGT TACTAGAGAC ATTAGAAAAC ATCAGCACTC TGGTGCCTCC GACAGCTCTT 1260

CCTCTGAATT TTTCTCGGAA ATTCATTGAC TGGAAAGGGA TTCCAGTGAA CAAAAGCCAA 1320

CTCAAAAGGG GTTACAGCTA TCAGATTAAA ATGTGTCCCC AAAATACATC TATTCCCATC 1380

AGAGGCCGTG TGTTAATTGG GTCAGACCAA TTCCAGAGAT CCCTTCCAGA AACTATTATC 1440

AGCATGGCCT CGTTGACTCT GGGGAACATT CTACCCGTTT CCAAAAATGG AAATGCTCAG 1500

GTCAATGGAC CTGTGATATC CACGGTTATT CAAAACTATT CCATAAATGA AGTTTTCCTA 1560

TTTTTTTCCA AGATAGAGTC AAACCTGAGC CAGCCTCATT GTGTGTTTTG GGATTTCAGT 1620

CATTTGCAGT GGAACGATGC AGGCTGCCAC CTAGTGAATG AAACTCAAGA CATCGTGACG 1680

TGCCAATGTA CTCACTTGAC CTCCTTCTCC ATATTGATGT CACCTTTTGT CCCCTCTACA 1740

ATCTTCCCCG TTGTAAAATG GATCACCTAT GTGGGACTGG GTATCTCCAT TGGAAGTCTC 1800

ATTTTATGCC TGATCATCGA GGCTTTGTTT TGGAAGCAGA TTAAAAAAAG CCAAACCTCT 1860

CACACACGTC GTATTTGCAT GGTGAACATA GCCCTGTCCC TCTTGATTGC TGATGTCTGG 1920

TTTATTGTTG GTGCCACAGT GGACACCACG GTGAACCCTT CTGGAGTCTG CACAGCTGCT 1980

GTGTTCTTTA CACACTTCTT CTACCTCTCT TTGTTCTTCT GGATGCTCAT GCTTGGCATC 2040

CTGCTGGCTT ACCGGATCAT CCTCGTGTTC CATCACATGG CCCAGCATTT GATGATGGCT 2100

GTTGGATTTT GCCTGGGTTA TGGGTGCCCT CTCATTATAT CTGTCATTAC CATTGCTGTC 2160

ACGCAACCTA GCAATACCTA CAAAAGGAAA GATGTGTGTT GGCTTAACTG GTCCAATGGA 2220

AGCAAACCAC TCCTGGCTTT TGTTGTCCCT GCACTGGCTA TTGTGGCTGT GAACTTCGTT 2280

GTGGTGCTGC TAGTTCTCAC AAAGCTCTGG AGGCCGACTG TTGGGGAAAG ACTGAGTCGG 2340

GATGACAAGG CCACCATCAT CCGCGTGGGG AAGAGCCTCC TCATTCTGAC CCCTCTGCTA 2400

GGGCTCACCT GGGGCTTTGG AATAGGAACA ATAGTGGACA GCCAGAATCT GGCTTGGCAT 2460

GTTATTTTTG CTTTACTCAA TGCATTCCAG GGATTTTTTA TCTTATGCTT TGGAATACTC 2520

TTGGACAGTA AGCTGCGACA ACTTCTGTTC AACAAGTTGT CTGCCTTAAG TTCTTGGAAG 2580

CAAACAGAAA AGCAAAACTC ATCAGATTTA TCTGCCAAAC CCAAATTCTC AAAGCCTTTC 2640

AACCCACTGC AAAACAAAGG CCATTATGCA TTTTCTCATA CTGGAGATTC CTCCGACAAC 2700 ^" ATCATGCTAA CTCAGTTTGT CTCAAATGAA TAA

Seq ID NO: 463 Protein sequence Protein Accession ft : Eos sequence 1 11 21 31 41 51 i i i i i i

MKVGVLWLIS FFTFTDGHGG FLGKNDGIKT KKELIVNKKK HLGPVEEYQL LLQVTYRDSK 60

EKRDLRNFLK LLKPPLLWSH GLIRIIRAKA TTDCNSLNGV LQCTCEDSYT WFPPSCLDPQ 120

NCYLHTAGAL PSCECHLNNL SQSVNFCERT KIWGTFKINE RFTNDLLNSS SAIYSKYANG 180

IEIQLKKAYE RIQGFESVQV TQFRNGSIVA GYEWGSSSA SELLSAIEHV AEKAKTALHK 240 LFPLEDGSFR VFGKAQCNDI VFGFGSKDDE YTLPCSSGYR GNITAKCESS GWQVIRETCV 300

LSLLEELNKN FSMIVGNATE AAVSSFVQNL SVIIRQNPST TVGNLASWS ILSNISSLSL 360

ASHFRVSNST MEDVISIADN ILNSASVTNW TVLLREEKYA SSRLLETLEN ISTLVPPTAL 420

PLNFSRKFID WKGIPVNKSQ LKRGYSYQIK MCPQNTSIPI RGRVLIGSDQ FQRSLPETII 480

SMASLTLGNI LPVSKNGNAQ VNGPVISTVI QNYSINEVFL FFSKIESNLS QPHCVFWDFS 540 HLQWNDAGCH LVNETQDIVT CQCTHLTSFS ILMSPFVPST IFPWKWITY VGLGISIGSL 600

ILCLIIEALF WKQIKKSQTS HTRRICMVNI ALSLLIADVW FIVGATVDTT VNPSGVCTAA 660

VFFTHFFYLS LFFWMLMLGI LLAYRIILVF HHMAQHLMMA VGFCLGYGCP LIISVITIAV 720

TQPSNTYKRK DVCWLNWSNG SKPLLAFWP ALAIVAVNFV WLLVLTKLW RPTVGERLSR 780

DDKATIIRVG KSLLILTPLL GLTWGFGIGT IVDSQNLAWH VIFALLNAFQ GFFILCFGIL 840 LDSKLRQLLF NKLSALSSWK QTEKQNSSDL SAKPKFSKPF NPLQNKGHYA FSHTGDSSDN 900 IMLTQFVSNE

Seq ID NO: 464 DNA sequence

Nucleic Acid Accession ft: AB035089.1

Coding sequence: 9845..10219

1 11 21 31 41 51

I I I I I I

GGGCATGCAG CCATCGGGGA AAATCCATAG TGCAGATAAA GCAAGGAGGA AGAAGAAGGA 60

CAGTTCTAGT AAAAGGGAGA ACATCAATAT AGGATGTTTC TTAGCAATAG AAAAAGAAGG 120

CCAAGAGGAA TTAGGGAGAG AGTTATAAGA GATCAGCAAG GGGACAGGGT TAGATTTGGT 180

TTGGTTTGAA AGCATACAGT AAATATGATG TCTGTCCCTG GCAGTGTTGG CAGAGTAGGA 240

AGGAGGAAGG GAGGCAAGAG ATAATATCAT TTTCTCTGTG CTCCAACTGT ACTTACATAT 300

GAGACTATTT CCCTCTCTGC TTTTCAAACC TTACTGGAGT TGTTTTCCCT CATGAAAACC 360

AAGAAAGGAA AGCTAGTTAG TCTTGTTCTG AGGTTGTTCA ATGTATACAT ATCTATATCT 420

GTAGACAGAA TCCTTGGGAA TACAGTAATT GACATATATT CTGTTATTTG ATGCTTGAAA 480

AATCTCCTCC ACTAACCAGT TTCCCTATAG ATTGCCACAA GCACATAATA AGAAACAATA 540

AATAAAATGT TCTCTTGACT TTGTTACTTA ACAATGCTGA GAAAACTTTA CAGCCTTCAT 600

AAGGAAGTGA GGTCCAGGAA AATCTAGGAG ATATTTCTTA ACCAATCTAT AAAGGCATTA 660

GTAATGACAG GATATTTCCT GAAAGTGTAA TTTCCCATTG AGGATTTGTT TTTAATTTCT 720

GGATTCCTGG AGCCAATGAA GTTGGTGTAT GTTTATGAAA TATCAAGAGA CATAAGTTGG 780

CAAGTGTTCA TATGCAAAAA CTTCTTGGAA TTTCTGAGTT CTCTGTGGCA ATATATGACA 840

TCAGGATATG TCCAGTCTCA CACACCAGGA TATGTCCTTT CTAGCCTGTC TATCACATGC 900

TAGGAGAACT ATTTAGGAAC AGAAAAAAAT GCCTGAAATG ATTTCTCATT TGAACTCATC 960

CAAGCTTTCT CTAAATTTAA GCAAACTCCT GGTCATTTTC AGTTAGTACC TTTCCTTAAG 1020

TTCAACCTTC AGGGCAAACC TCCGTGCCTC AGACGTTTAG CCATAGTCTG AAATTCTCTT 1080

CCATAGATTG GTCCCCTGTA ACCCCGGTTT GTCTCAGCTT GTTATCCTGT TTTTTTCTTC 1140

CCTCCATTCC CAGGATGAGC TTGTTGCTTC TGTCCTATGA GACATTAGAT TCCTTTTCTT 1200

TGGTACCCGA GTAAATCCAT CCTACTCCAA TAGAGGAAGG TCCATTTTTG TCTTATAGCG 1260

CTGGATGCAG ACTCAGCTGA GAAGACCATT ATTCATTTTT GGAATTCTTT ATCTCAGATA 1320

TTTCCTCTTC TTTCTTTTTC TTCTATCTTT GGATTTTTAG TCCATCAACG CCCCATTAGT 1380

CTATTCCCCG ACTTCAATCA GGGAACTTAT ACCTCTTAAA CTCATTCAGA GACTCAAAAC 1440

ATATATATTG ATACAGGAGA CCTAAGAAGA GCATGTCTTG GGGGTTGAGG AAACAGGCAG 1500

GTGAGAAATT TCCAGATTGG AAACACAGCT TCCTTTCTGC CATCCAGCCC CTACTTTCAG 1560

CCTATGTGTT TCTGGCACCT TGTTGTAGAT AAATCTCCCT TGACTTTGTG ATGTGCTGAG 1620

AAAACAAACT CACGGCTGGT GTTAAAAAGG GCCCATGACA ATACCAAGTG TTGGGGAGAA 1680

TGTGGAGAAA TCAGAACTCT ATTCACGGTC GGTTGGAATG CACACTTGTG CAGAATTCTA 1740 TGGAGAAGAG TCTGGCATTT CCTCAAAATG TTAACCTGGA TTTACCATAT GACCCAGCGA 1800 TTTCATTCAT AGGTTTATAC TCAAAAGAAA TGAAGAAATA TGCCATGCAA AAAAATGTAC 1860 ATGAAAGGTC ACAACATCAT TATTCATAAT AGTAAAAGGA TGGAAACAAC ACAAATGTCC 1920 ATCAACTTAT GATTAAAGAA AATCTGGTCT ATTCATAGAA TGGAATATTA TTCGACCACA 1980 AAAAGGAATG ATGTACTGAT CCATGCAATG ATGTGGACAA ACCATGAAAA TAACACTAGA 2040 TTAAAGAAGC CAGTCACAAA AGGACTTACT GTATGATTCC ATTTACCTGA AATGTTTGGA 2100 ATAGGCAAAT CCATAGAAAC AGGAGGTAGA TTCCTGGTTT CCAGGGTCTC CAGGAAGGGA 2160 AGAATGAAGT ACAAGATTTC TTTTGGAGGT AGTGAAATTG TTGTGGAATG AGATCATGAT 2220 GATGATAGCA CAACTTTGTG AATATAATAA AATCATTGAA TTGTACAGTT GAATTTATGG 2280 TATATAAATT ATATGTTAAT AAAAAGGGGG TCCACAAAAC AAACAGCCCC CCACTCTGGT 2340 TGTCAGGGAG ATATTGGATT AAATGGCCTT GGACAACAAC CCCTCTCCCT GGCCACAGAC 2400 ATTCTTCAGA TTACAAGATA TTCCAGGGGA AACACTGGAA TGAGTCTGAA GCCAGGTGCT 2460 AAACAGAAGG ACCATTGAGA AATGTTGTGA TCCTGACAGG TCAAGCAATT TATTTTTCGG 2520 CTTCATTTTT AAATGTAAAA TTAGAAAGCT GCCATTTAAA ATGGCCCGTC TGTTTCAATT 2580 GCTCTTCTCA GTGTCAGCCT GTTAACTCAA TGTGTTAGTC TGTTTTCATG CTGCTGATAA 2640 AAACATACCT GAGACTGGCA AGAAAAAGAG GTTTAATTGG GCTTAGAGTT CCACGTGATT 2700 GGGGAGGCCT CAGAATCACA GTAGGAGGCA AAAGTTATTC TTACATGGTG GCTGCAAGAG 2760 AAGATGAGGA AGAAGCAAAA GAAGAAACCC CTGATAAACC CATCGGATCT CCTGAGGCTT 2820 ATTAACTATC ATGAGAATAG CACAAGAAAG ACCGGCCCCC ATGATTCAAT TACCTCTACC 2880 TGGGTCCCTC CAATAACATG TGGAAATTCT GGTAGATACA ATTCAAGTTG AGATTTGGGT 2940 GGGAACACAG CCAAACCATA TCACTCAGCA AGGCAGATAA CTTTCTCACT GAGCCTATGC 3000 AACAGAAAAC CATCTGGGAT GGTTGTAAGG GGCACAGGAA GTGACTGGTA GGATCACTGC 3060 CAAAGCTGAG CACTCAGGAG AAGGCAATAG AATCCTATTC TCCATAGTAT GCTATAAGAT 3120 ACTGAAGTAC ACTTCTTCAC TATCTCTTTG GACTTAGAAT TAGCACTACA TTCCTTGTTA 3180 TACAGAAAAA TTACTAAGGA AATTCATAGG ATGACAAAAA CTTTCAGAAC TGAAAAACAG 3240 GAAATGTAAG CTTTTTAGTT CTTTGGTATT CGAAGTATGC CTAAAAGACA ATGCAAAATC 3300 CAAGAAAAGA ATGGTGGGGT TTTTGTTTGT TTGGTTTTGT TTTTGTTTTA CAGCTGGAGT 3360 AGAATACAAA GGGATGGAGT TGAAACAAAT ^"GAGAGGAAAT TGGAATTCTA AACTTATTCT 3420 CATTGGCATT AGAAAGGCAC CTACATGTAT TTCACATGAG CCGGTGACTG CTGACTTGCA 3480 TTCTTATTTT TTCCCTATAG ATTAAAAAGG AGGTACAATG GTAGAACTGT AATCCTGTCC 3540 TTTGTCATAA ATTTTCATAT TCATAAAGGT GAGTGTTAGC CCGCTTGTGA AATCTGAAGT 3600 TGAGTAACTT CAAATACTAA CCACAGAGGG AAAGGCAGCA AGAGGAGAGG CATAAATTTA 3660 GGATCTCACC CTTCATTCCA CAGACACACA CAGCCTCTCT GCCCACCTCT GCTTCCTCTA 3720 GGAACACAGG TAAGAGCTTC AAGCCTCTCC AGCTTAATAA CATGAATTAT TTTTGAGAAT 3780 AATAATGATA CTGTGTTCTA TATCATGCAT CTCCTGCATT CTGTCTGATT ATATTTTACT 3840 TATTCTGCCA GAGCAAAATT AAAATACCTA TTTCATCTGA TTTGTCCTTT ATCTAAATTG 3900 CTTAGTTCCA AGTAAACCAA GGCACTTTTA GGAACACAGA GGGAGAGTGC CTTGCAGCCA 3960 GAGAGTCTTG AAGGAGATGT CAGGGACGCA TCTTAACAGC TGGTTGGATG TGATCCACAG 4020 AGGTCTCCTG TTAGCATTCA TTGTAAAGCC ATCCTACCTA GCTCTAGTGT AACCAGCAAT 4080 GAAAGAAAGA TAAAGAGGGT CGATTACTTA TTTACAATAG TCTTTAAAAA CGTAGTTTTG 4140 TAAGCCTTCT AATTAGGACA TTAATATATT TAATATATGC ACATTGTAGA AAGATTGAAG 4200 CGTTAAAAAT AAGAGAAAAA CTTTAAATGT CAAAATCTCA CAACCCAGAT ATATCATTTC 4260 TTTAAGAAAA TTGTACTACA AAATACCATT CCATTTATTA AAGTCATTCT GACAGGAATC 4320 TGATGCTTTT CCAGGAGTTC CAGATCACAT CGAGTTCACC ATGAATTCAC TCAGTGAAGC 4380 CAACACCAAG TTCATGTTCG ATCTGTTCCA ACAGTTCAGA AAATCAAAAG AGAACAACAT 4440 CTTCTATTCC CCTATCAGCA TCACATCAGC ATTAGGGATG GTCCTCTTAG GAGCCAAAGA 4500 CAACACTGCA CAACAAATTA GCAAGGTAGC TATCAGCATC ATTACGTTGT CCTGTTGCAG 4560 TTTTTCTCTG GTTCCGTCGG CTAGCACGCA GATGGTAATA GATGTGGTGG TCTGATGGGT 4620 AGCACAGGGG GCTGTGCAGG AATTCCCATA ACTGTGAGAC CACTGACTTA AACAGATCTT 4680 TTGAGTAAAG TTTTCTTGTC CCGCTTCATG TCTCTTCCAG GTTCTTCACT TTGATCAAGT 4740 CACAGAGAAC ACCACAGAAA AAGCTGCAAC ATATCATGTG AGTCACAGAG CACTCTGATT 4800 CAGCTTTAGA TCCCTGAACA GGTCATAGTT TAAACCTGGA ACTTCACAAA AACTAAGAAA 4860 AGGCCAGTTT TAGGGAAAAT CTTGGACACA AAGATTGAGA CATACAGAGT GGGTTGGCAT 4920 TTCATGGCAC ATAATTATTA TTCCTCATTT CTGCGTTACT AAAAGACAGT CAGCACTGTA 4980 CCTCAGAGCA TAGGTCTGGA TCAGGATAGG CTGGGTTCAG ACTCCAGCTT TGCTCTTCAC 5040 AAATGATGAA TAAGAGCAGG ACACAACTGC TCGGAGTCCC AGTGACCTCA TCCCAGAAAA 5100 CTAAGGGTAA GAAAAAATCT GACTCAATAC ATGCAAATAC ATGCAAATGT TTACAACAGT 5160 GCCTTGCCCA TAAAAGTCAT AATAAATGTT ATTATTATTA TAAAGTAGCT ATAATTATAC 5220 TAATCATAAT AATGTGAAAA TAATTTAATT TTCATTGAGT CATTAATGAG ATTCAGAGGA 5280 ATAAGCACAA GTCCAAGTAT ATTTTGGAAA ATGATTGCTA TGGAATATAT TGGTTTAGAG 5340 CCTTAATAGT GCAAAATGCT TTGCTGGAAG GTAGAAAGTT CTAGATTTAA ACAGGCTTAG 5400 GTTCAAAACT TGGCACTTCT AATTTATGTC TCTATAAACA GGGTTTTTTT CCCCATTCTC 5460 TGAGCTTTCT TGTGTTCATC TGAATTGAAC TAAAGACTTA GAGTTACCCA TGTAAAGTCC 5520 TTAGCCATGG ACCTGGCATA CACTCTTCTT ACGTGCAGAG AATGACCATC ATGAGGAAAG 5580 AGCCACAGAT CAGTCAATGT GTCCTACAAG ATAATAGCAC CAACAGGTAT AACAGGGCTT 5640 CCTGGCATAA TCTATTTAAA ATATCCAACC TTCAACATAC TCGTATCCTT GATGACTGTT 5700 AGAAGTGAAA TATGGTCCTT GCCCATAAGG AGCTGAGAGT TTAACTGGGA AGCTAAACCT 5760 AACCCTTTAA ACCAACAAGG AGAAAATCTA CTGGTAGACA GCGCTGCATC TTTAGTTCAG 5820 AAGAGAAAAG ATTGCAGTAC GTTAGAGCAA GAAGAATTTT CTGGAAGAAG TCAAATATAA 5880 GGTGGATTTT GAAGGGTATT TGAGGTGAAA TACACCAATT ATCAGGGAAT AACATCAAAG 5940 GTCCTCAATG AGACTACCAG CATTTAGGGA CTGATCTAAC AGACTTAGCA TGGGTTTAGT 6000 ATTTACATTG ATACAGCAAT TGAATGATCT CCTTTTTTGA TGTTTGAAGG TTGATAGGTC 6060 AGGAAATGTT CATCACCAGT TTCAAAAGCT TCTGACTGAA TTCAACAAAT CCACTGATGC 6120 ATATGAGCTG AAGATCGCCA ACAAGCTCTT CGGAGAAAAG ACGTATCAAT TTTTACAGGT 6180 AATTTCACCT GGCCTACCCA CATTTCATTT GCATCCTGAT GTCTGTGTCT CTGAGTGGCC 6240 AAATGGAAGA AAGCAAGGCA GATGAGCCTG GCCGACCCAG GTGGAGAGCA TTTACTCAGA 6300 GTGCATTAGC TCCATTTCCA CAACTCTCCC CCACTGGAGT GTCCCAGACC CCAACGATAC 6360 ATCACTGAAG TGTGGATTTA GGGATAATCT TGTGATAAAA GAGGAGGTTG TGTAATAGAG 6420 TGAGTAAGAG TAATAAGTAA TAAGATACCA TCGATAAACT GGCACTGACT CAGTCACATA 6480 CGATACATCT TGGTGGGAAA TGTATGACTA ATGGGATATT ATTGGAATGG GCAGGCTTGG 6540 GTGAGTTCCT GAGAATAGTT GAGGAAGTAC CAGGAAATAT TGAATGCACA GGATGAAAGA 6600 CAAAAACAAA GATCAGAAAC ATCATGGTTA AAATTACTGG AGAGAAGTCT GAGAAGCAAT 6660 GAATCTCCTT CAGGGAAGCC TGCTCTGCAG TTTGCAAACC ACAGCCTCTT CTGCTTCTGC 6720 CTTTTGCCAA GATGATATTG ACCTTCAGTG ACCTCTTTCT TGTGCCAGCC CACATTCCCC 6780 TTTTGCATTG CCTACATGAC ACCTGTATAA AAATATCCAT GGACAGGAGA TACTGCATCT 6840 ATTCAGGGTC TGGATTCAGC TTACTGTTGT TACAAATAAG TAAGTTTGGT AATATATAGT 6900 TACATAAATT ACTCCTAATT CCTACTTCTT CCTTCATATC TCAAAGGAAT ATTTAGATGC 6960 CATCAAGAAA TTTTACCAGA CCAGTGTGGA ATCTACTGAT TTTGCAAATG CTCCAGAAGA 7020^" AAGTCGAAAG AAGATTAACT CCTGGGTGGA AAGTCAAACG AATGGTAGGA GAGCCACCCA 7080 TTATAGAAAC ACCTTTGAGA AACCTATGCC AGTGAGCCTT GTGCTTGACA CTGCATGGGG 7140 GAACAGGTGT GGGGATTGAG ATGGGTTTGC AGGGAGGGCT GAAGAGGGCA CTCCAGATGA 7200 AGGATTTGTC CAAATGAATA TGAAGAGAGC CTAGGGGAGC CAAGGAGGAA ATCACAGGAA 7260 GCCAATTAGA TGGAAACACA TCTGGAGAAT TATTTGCTTA TGGCCCTGCA TGACAATAGC 7320 TTTGTGGATC CCCTGTCTCC GCTCAGACCT ATTTTGAGAT CATATCCTTT ACTTTAAATC 7380 AGACTCAAAT TTTTATGATG AATATTTAAT AGAAAACATT AGAAAGCGTC TCTCGTCTCC 7440 TTTACTAATT GGGAAACAAG CAGCTCTCTG GTAAATCACC CTTTTGTCTC TGAGCTGGAG 7500 CTGCCTGGAT CACATCTGTA GCCAATGTGT TCTGCAGGGA TTATCACAGC TCTCTTCCCC 7560 ATCAAGGGCA AAGAGCTTGA CAAAGTCTCC ATTCTACAGA CATCTTTCTT ACCTCCCACC 7620 TCTCATTACA GGCCAAACTT ACAGCAACTC AACATGAGAG TGAATAGGAA GATACCCCCG 7680 GAAGTAGTGT CTGACAGCAC AGGACATGCG TTTCATATTA CAGAGCTCAA GTCACTCATC 7740 CTAAAATGCA ATCAGGGCCT CCTTCCTCTG AATGGGGACC CCGTAGTTAA AAAAAAATAA 7800 AAGTAGGAAG AGGAGGGAGG GAGAAAGGAA AGACACATGT TGGAAGAGTA GACAAAATCA 7860 GTTTATCAGT ATTCCAAATC AGATGATTGG AGACATTCAT ACACAGAGAA CGTGAACTCC 7920 TTCTCTATCA CAAGAAGTGA TGTCTCCATC AAGGGTAACT TTATACGACT GGAGCCTTGA 7980 AGAAAGCTGC ATCTGGTGAA CCACTGGTCA GTGAGTCTAA CAATTCAAAG ATCAAAGTCA 8040 GTGAGTCTCA AGCAGGGATT TGGGTCAATA ATTAACGATC AGTCACGAAC ATTTGCAAAG 8100 CATCTTCCAG ACAAGCCATT TGTAGCTTGT GTAAAAGACT CTTTTATTCT TTCCCTTGCA 8160 GAAAAAATTA AAAACCTATT TCCTGATGGG ACTATTGGCA ATGATACGAC ACTGGTTCTT 8220 GTGAACGCAA TCTATTTCAA AGGGCAGTGG GAGAATAAAT TTAAAAAAGA AAACACTAAA 8280 GAGGAAAAAT TTTGGCCAAA CAAGGTATTG TCTATATTTT ATTTATATAG TGTAATATGT 8340 TAATACATGG AATGTTAAAC ATTTCTGATG GAATGTAACA TGATAAGTAA AAAATAAAAA 8400 TTGTTCATGT CTGTTATTTT GTTGTTTTAC TCTTATAACT TTATTTAGTT AGGAATACCT 8460 GAAAAACTAT TGTTTCTAAC TCATGGAATT CCTGGGTTAT TTCTTAGAAG AAGAAGGATG 8520 TGTTGCTATC TCAATAATAT TATCTTTTTT GTCTTGTGTT TCACGTGTTA TTTGTTGGAC 8580 ACATTGATTT ATTGCAGAAT ACATACAAAT CTGTACAGAT GATGAGGCAA TACAATTCCT 8640 TTAATTTTGC CTTGCTGGAG GATGTACAGG CCAAGGTCCT GGAAATACCA TACAAAGGCA 8700 AAGATCTAAG CATGATTGTG CTGCTGCCAA ATGAAATCGA TGGTCTGCAG AAGGTAAGAA 8760 CTTGCATCTA CAACTCTTCC TTCTACTGCC GGACATTTTT CCAAAGATAC CAAGTTTAAA 8820 CAAGGTAAAA GCTTATGACC GAGTTGCCTC AAAATGATGA AAAATTCTAA ATGAGGAATG 8880 ATGACTCACC TTCATATTAC AAATATTTGA GCATAGGGCC TGACACAAAC TGAAAGCTTA 8940 GTTTTTGTTT GTTTGTTTGT TTTTATTATT ATTATTATAA TACTTTAAGC TTTAGGGTAC 9000 ATGTGCACAA TGTGCAGGTT AGTTACATAT GTATACATGT GCCATGCTGG TGTGCTGCAC 9060 CCATTAACTC ATCATTTAGC GTTAGGTATA TCTCCTAATG CTATCCCTCC CCCCTCCCCC 9120 CACCCCACAA CAGTCCTCAG AGTGTGATGT TACCTTCCTG TGTCCAAGTG TTCTCATTGT 9180 TCAATTCCCA TCTATGATTT AATTCCATCT ATGGCTTAGT TAATGATTAA TTTATTAGAG 9240 TTACATGCAT TGGATATCAA TTTGATGATA TTATTATGCA GCAATTTAAA CTTGACTGGG 9300 AGAAATATAT ACCAATGTGA GGAAAGTTTA CAAATAGGCC GAGTAGAAAA GGGAATACAA 9360 ATTTAGGAAT TTAGGGAATT ACAATTTAAT AATTGCAATG TGTACTAAAT AATGTATACA 9420 GAAAAATATG ATGAGCCTAT TAAAAATTGA CACATGTAGT AGGCTGTTGG CACAAGAAAT 9480 AGTGATACAT ACAGTTCATT GTGTACAAAA TAATGTAATC ATATTTTACA TGTGTATCAT 9540 ACAGTTGTAT ACATACATAT GTACACATAT ACATATACGT AAAAACATGA TTCTGTTTTT 9600 ACATACATGT ATATACATAT ACACATATAA CCCAATGTAT TTATATATTC AGGACTCATA 9660 TTTTACCTAT TAGAATAATA ATGTCTATTA AAGTGAACCT TCTGTATTTC ACATTTATTG 9720 CCAAAATAAC GAATCTCCAC ATAGTCAATT CATTGTTAAG GTGTATTAGA GATCGACAGT 9780 TAGTCATATC AGTTTCTTTT TTCCATTTGT ATAGCTTGAA GAGAAACTCA CTGCTGAGAA 9840 ATTGATGGAA TGGACAAGTT TGCAGAATAT GAGAGAGACA TGTGTCGATT TACACTTACC 9900 TCGGTTCAAA ATGGAAGAGA GCTATGACCT CAAGGACACG TTGAGAACCA TGGGAATGGT 9960 GAATATCTTC AATGGGGATG CAGACCTCTC AGGCATGACC TGGAGCCACG GTCTCTCAGT 10020 ATCTAAAGTC CTACACAAGG CCTTTGTGGA GGTCACTGAG GAGGGAGTGG AAGCTGCAGC 10080 TGCCACCGCT GTAGTAGTAG TCGAATTATC ATCTCCTTCA ACTAATGAAG AGTTCTGTTG 10140 TAATCACCCT TTCCTATTCT TCATAAGGCA AAATAAGACC AACAGCATCC TCTTCTATGG 10200 CAGATTCTCA TCCCCATAGA TGCAATTAGT CTGTCACTCC ATTTAGAAAA TGTTCACCTA 10260 GAGGTGTTCT GGTAAACTGA TTGCTGGCAA CAACAGATTC TCTTGGCTCA TATTTCTTTT 10320 CTATCTCATC TTGATGATGA TAGTCATCAT CAAGAATTTA ATGATTAAAA TAGCATGCCT 10380 TTCTCTCTTT CTCTTAATAA GCCCACATAT AAATGTACTT TTCCTTCCAG AAAAATTTCC 10440 CTTGAGGAAA AATGTCCAAG ATAAGATGAA TCATTTAATA CCGTGTCTTC TAAATTTGAA 10500 ATATAATTCT GTTTCTGACC TGTTTTAAAT GAACCAAACC AAATCATACT TTCTCTTCAA 10560 ATTTAGCAAC CTAGAAACAC ACATTTCTTT GAATTTAGGT GATACCTAAA TCCTTCTTAT 10620 GTTTCTAAAT TTTGTGATTC TATAAAACAC ATCATCAATA AAATAATGAC ATAAAATCAT 10680 TTTTGCTTTA CCTGTTTTCT CTCTGGAAAG GGCAAGTGTC CAGTTACACA TAGGAAAGAT 10740 AATTTAGAGA TATATTAATC ATATATAAAG GAAAATTAAA AACAGAGTAG TTCATGATGA 10800 GCCTGGAGTA GAAGGCATAT CCCAGAACAG GAGGAGCCTT GTAAACCACA TAGGAACTTC 10860 CTATTTTATG CTAAAGGGAT AAGAAACTCA TTACAGGCTT TGATGGTTGT TTGTCAAAGA 10920 GGGGCATAAA ATTATCATAT CCACATCTAG AAAATACATC TCTGGCTACG CTGATATCAA 10980 TGGATGCGAG GAAAGAACAG TGTGGTTACC ATATATAAAT TAGGAAATCA TTAGAGTATT 11040 GGGAGTGGAA ATGGAGAGAA AGAAAGAGCC TGGGGGAATT ATTTAGGAAA TAATAGTTAC 11100 AGAAAGACAT CTAAGTTGCT GACCTATCTG ACTGGATGGA TGGAAGAATA TCTTGTTTCT 11160 GAGAGAAAAA AAGACTTTGG GTTTAAATTT GTACTTGATG AATTAAGGTA CTTTTAATAT 11220 TCAAATGGAT TTGCCTGGCA GGCACTTGAA GATATTAGTC TAAATCTCAG AAACAGAATA 11280 TGATCTGAAG CTCTAAATTT GTGATATTCA ATATAAATAC TTTAGAGTCA TTGGGATAAA 11340 TATGGTAGTT GTAGCTAAAA GCAAAAATAA GATACTAGGG AGAAAGGATA AAGTTAGAAG 11400 AAAGAAGAAT CTAGAATTGA CCTTGAAGTA TATCAGCATG TGTAAAGATC AGGAATTGAT 11460 CATTTTTATT TTCCAGAAAG TAGCTTTTCT TAGGGTTCCA TATTTACTCC CATAGATTCT 11520 TCCC

Seq ID NO: 465 Protein sequence Protein Accesεion ft: BAB21525.1

11 21 31 41 51

MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA QQISKVLHFD 60 QVTENTTEKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE LKIANKLFGE KTYQFLQEYL 120

DAIKKFYQTS VESTDFANAP EESRKKINSW VESQTNEKIK NLFPDGTIGN DTTLVLVNAI 180

YFKGQWENKF KKENTKEEKF WPNKNTYKSV QMMRQYNSFN FALLEDVQAK VLEIPYKGKD 240 LSMIVLLPNE IDGLQKLEEK LTAEKLMEWT SLQNMRETCV DLHLPRFKME ESYDLKDTLR 300

TMGMVNIFNG DADLSGMTWS HGLSVSKVLH KAFVEVTEEG VEAAAATAW ELSSPSTN 360 EEFCCNHPFL FFIRQNKTNS ILFYGRFSSP

5 Seq ID NO: 466 DNA sequence

Nucleic Acid Accession ft: NM_001910.1 Coding sequence: 50..1240

_{Λ Λ} 1 11 21 31 41 51

10 i i i i i i

GGAGAGAAGA AAGGAGGGGG CAAGGGAGAA GCTGCTGGTC GGACTCACAA TGAAAACGCT 60

CCTTCTTTTG CTGCTGGTGC TCCTGGAGCT GGGAGAGGCC CAAGGATCCC TTCACAGGGT 120

GCCCCTCAGG AGGCATCCGT CCCTCAAGAA GAAGCTGCGG GCACGGAGCC AGCTCTCTGA 180

GTTCTGGAAA TCCCATAATT TGGACATGAT CCAGTTCACC GAGTCCTGCT CAATGGACCA 240

15 GAGTGCCAAG GAACCCCTCA TCAACTACTT GGATATGGAA TACTTCGGCA CTATCTCCAT 300

TGGCTCCCCA CCACAGAACT TCACTGTCAT CTTCGACACT GGCTCCTCCA ACCTCTGGGT 360

CCCCTCTGTG TACTGCACTA GCCCAGCCTG CAAGACGCAC AGCAGGTTCC AGCCTTCCCA 420

GTCCAGCACA TACAGCCAGC CAGGTCAATC TTTCTCCATT CAGTATGGAA CCGGGAGCTT 480

GTCCGGGATC ATTGGAGCCG ACCAAGTCTC TGTGGAAGGA CTAACCGTGG TTGGCCAGCA 540 0 GTTTGGAGAA AGTGTCACAG AGCCAGGCCA GACCTTTGTG GATGCAGAGT TTGATGGAAT 600

TCTGGGCCTG GGATACCCCT CCTTGGCTGT GGGAGGAGTG ACTCCAGTAT TTGACAACAT 660

GATGGCTCAG AACCTGGTGG ACTTGCCGAT GTTTTCTGTC TACATGAGCA GTAACCCAGA 720

AGGTGGTGCG GGGAGCGAGC TGATTTTTGG AGGCTACGAC CACTCCCATT TCTCTGGGAG 780

CCTGAATTGG GTCCCAGTCA CCAAGCAAGC TTACTGGCAG ATTGCACTGG ATAACATCCA 840 5 GGTGGGAGGC ACTGTTATGT TCTGCTCCGA GGGCTGCCAG GCCATTGTGG ACACAGGGAC 900

TTCCCTCATC ACTGGCCCTT CCGACAAGAT TAAGCAGCTG CAAAACGCCA TTGGGGCAGC 960

CCCCGTGGAT GGAGAATATG CTGTGGAGTG TGCCAACCTT AACGTCATGC CGGATGTCAC 1020

CTTCACCATT AACGGAGTCC CCTATACCCT CAGCCCAACT GCCTACACCC TACTGGACTT 1080

CGTGGATGGA ATGCAGTTCT GCAGCAGTGG CTTTCAAGGA CTTGACATCC ACCCTCCAGC 1140 0 TGGGCCCCTC TGGATCCTGG GGGATGTCTT CATTCGACAG TTTTACTCAG TCTTTGACCG 1200

TGGGAATAAC CGTGTGGGAC TGGCCCCAGC AGTCCCCTAA GGAGGGGCCT TGTGTCTGTG 1260

CCTGCCTGTC TGACAGACCT TGAATATGTT AGGCTGGGGC ATTCTTTACA CCTACAAAAA 1320

GTTATTTTCC AGAGAATGTA GCTGTTTCCA GGGTTGCAAC TTGAATTAAG ACCAAACAGA 1380

ACATGAGAAT ACACACACAC ACACACATAT ACACACACAC ACACTTCACA CATACACACC 1440 5 ACTCCCACCA CCGTCATGAT GGAGGAATTA CGTTATACAT TCATATTTTG TATTGATTTT 1500

TGATTATGAA AATCAAAAAT TTTCACATTT GATTATGAAA ATCTCCAAAC ATATGCACAA 1560

GCAGAGATCA TGGTATAATA AATCCCTTTG CAACTCCACT CAGCCCTGAC AACCCATCCA 1620

CACACGGCCA GGCCTGTTTA TCTACACTGC TGCCCACTCC TCTCTCCAGC TCCACATGCT 1680

GTACCTGGAT CATTCTGAAG CAAATTCCGA GCATTACATC ATTTTGTCCA TAAATATTTC 1740 0 TAACATCCTT AAATATACAA TCGGAATTCA AGCATCTCCC ATTGTCCCAC AAATGTTTGG 1800

CTGTTTTTGT AGTTGGATTG TTTGTATTAG GATTCAAGCA AGGCCCATAT ATTGCATTTA 1860

TTTGAAATGT CTGTAAGTCT CTTTCCATCT ACAGAGTTTA GCACATTTGA ACGTTGCTGG 1920

TTGAAATCCC GAGGTGTCAT TTGACATGGT TCTCTGAACT TATCTTTCCT ATAAAATGGT 1980

AGTTAGATCT GGAGGTCTGA TTTTGTGGCA AAAATACTTG CTAGGTGGTG CTGGGTACTT 2040 5 CTTGTTGCAT CCTGTCAGGA GGCAGATAAT GCTGGTGCCT CTCTATTGGT AATGTTAAGA 2100 CTGCTGGGTG GGTTTGGAGT TCTTGGCTTT AATCATTCAT TACAAAGTTC AGCATTTT

Seq ID NO: 467 Protein sequence Protein Accession ft: NP_001901.1 0

1 11 21 31 41 51

I I I I I I

MKTLLLLLLV LLELGEAQGS LHRVPLRRHP SLKKKLRARS QLSEFWKSHN LDMIQFTESC 60

SMDQSAKEPL INYLDMEYFG TISIGSPPQN FTVIFDTGSS NLWVPSVYCT SPACKTHSRF 120 5 QPSQSSTYSQ PGQSFSIQYG TGSLSGIIGA DQVSVEGLTV VGQQFGESVT EPGQTFVDAE 180

FDGILGLGYP SLAVGGVTPV FDNMMAQNLV DLPMFSVYMS SNPEGGAGSE LIFGGYDHSH 240

FSGSLNWVPV TKQAYWQIAL DNIQVGGTVM FCSEGCQAIV DTGTSLITGP SDKIKQLQNA 300

IGAAPVDGEY AVECANLNVM PDVTFTINGV PYTLSPTAYT LLDFVDGMQF CSSGFQGLDI 360 HPPAGPLWIL GDVFIRQFYS VFDRGNNRVG LAPAVP 0

Seq ID NO: 468 DNA sequence

Nucleic Acid Accession ft: NM_018058.1

Coding sequence: 319..1575 5 1 11 21 31 41 51

I I I I I I

TACGCGCTGC GGGACCGGCA GGGGAACGCC ATCGGGGTCA CAGCCTGCGA CATCGACGGG 60

GACGGCCGGG AGGAGATCTA CTTCCTCAAC ACCAATAATG CCTTCTCGGG GGTGGCCACG 120

TACACCGACA AGTTGTTCAA GTTCCGCAAT AACCGGTGGG AAGACATCCT GAGCGATGAG 180 0 GTCAACGTGG CCCGTGGTGT GGCCAGCCTC TTTGCCGGAC GCTCTGTGGC CTGTGTGGAC 240

AGAAAGGGCT CTGGACGCTA CTCTATCTAC ATTGCCAATT ACGCCTACGG TAATGTGGGC 300

CCTGATGCCC TCATTGAAAT GGACCCTGAG GCCAGTGACC TCTCCCGGGG CATTCTGGCG 360

CTCAGAGATG TGGCTGCTGA GGCTGGGGTC AGCAAATATA CAGGGGGCCG AGGCGTCAGC 420

GTGGGCCCCA TCCTCAGCAG CAGTGCCTCG GATATCTTCT GCGACAATGA GAATGGGCCT 480 5 AACTTCCTTT TCCACAACCG GGGCGATGGC ACCTTTGTGG ACGCTGCGGC CAGTGCTGGT 540

GTGGACGACC CCCACCAGCA TGGGCGAGGT GTCGCCCTGG CTGACTTCAA CCGTGATGGC 600

AAAGTGGACA TCGTCTATGG CAACTGGAAT GGCCCCCACC GCCTCTATCT GCAAATGAGC 660

ACCCATGGGA AGGTCCGCTT CCGGGACATC GCCTCACCCA AGTTCTCCAT GCCCTCCCCT 720

GTCCGCACGG TCATCACCGC CGACTTTGAC AATGACCAGG AGCTGGAGAT CTTCTTCAAC 780 0 AACATTGCCT ACCGCAGCTC CTCAGCCAAC CGCCTCTTCC GCGTCATCCG TAGAGAGCAC 840

GGAGACCCCC TCATCGAGGA GCTCAATCCC GGCGACGCCT TGGAGCCTGA GGGCCGGGGC 900

ACAGGGGGTG TGGTGACCGA CTTCGACGGA GACGGGATGC TGGACCTCAT CTTGTCCCAT 960

GGAGAGTCCA TGGCTCAGCC GCTGTCCGTC TTCCGGGGCA ATCAGGGCTT CAACAACAAC 1020

TGGCTGCGAG TGGTGCCACG CACCCGGGTT GGGGCCTTTG CCAGGGGAGC TAAGGTCGTG 1080 5 CTCTACACCA AGAAGAGTGG GGCCCACCTG AGGATCATCG ACGGGGGCTC AGGCTACCTG 1140

TGTGAGATGG AGCCCGTGGC ACACTTTGGC CTGGGGAAGG ATGAAGCCAG CAGTGTGGAG 1200

GTGACGTGGC CAGATGGCAA GATGGTGAGC CGGAACGTGG CCAGCGGGGA GATGAACTCA 1260 GTGCTGGAGA TCCTCTACCC CCGGGATGAG GACACACTTC AGGACCCAGC CCCACTGGAG 1320

ACACCAATGA ATGCATCCAG TTCCCATTCG TGTGCCCTCG AGACAAGCCC GTATGTGTCA 1380

ACACCTATGG AAGCTACAGG TGCCGGACCA ACAAGAAGTG CAGTCGGGGC TACGAGCCCA 1440

ACGAGGATGG CACAGCCTGC GTGGGGACTC TCGGCCAGTC ACCGGGCCCC CGCCCCACCA 1500

CCCCCACCGC TGCTGCTGCC ACTGCCGCTG CTGCTGCCGC TGCTGGAGCT GCCACTGCTG 1560

CACCGGTCCT CGTAGATGGA GATCTGAATC TGGGGTCGGT GGTTAAGGAG AGCTGCGAGC 1620

CCAGCTGCTG AGCAGGGGTG GGACATGAAC CAGCGGATGG AGTCCAGCAG GGGAGTGGGA 1680

AAGTGGGCTT GTGCTGCTGC CTAGACAGTA GGGATGTAAA GGCCTGGGAG CTAGACCCTC 1740

CCCAAGCCCA TCCATGCACA TTACTTAGCT AACAATTAGG GAGACTCGTA AGGCCAGGCC 1800

10 CTGTGCTGGG CACATAGCTG TGATCACAGC AGACAGGGTC GCTGCCCTGA TGGCGCTTAC 1860

ATTCCAGTGG GTCTAATGAC CATATCTTAG GACACAGATG TGCCCAGGGA GGTGGTGTCA 1920

CTGCACAGGA AGTATGAGGA CTTTAGTGTC CTGAGTTCAA ATCCTGATTC AGGAACTCAC 1980

AAAGCTATGT GACCTTACAC CAGTCACTTA ACTTGTTAGC CATCCATTAT CGCATCTGCA 2040

AAATGGGGAT TAAGAATAGA ATCTTGGGGT TAGTGTGGAG ATTAGATTAA ATGTATGTAA 2100

15 GACACTTGGC ACAAAACCTG GCACATAGTA AAGGCTCAAT AAAAACAAGT GCCTCTCACT 2160 GGGCTTTGTC AACACGTG

Seq ID NO: 469 Protein sequence Protein Accession ft : NP_060528.1

20

1 11 21 31 51

MDPEASDLSR GILALRDVAA EAGVSKYTGG RGVSVGPILS SSASDIFCDN ENGPNFLFHN 60

RGDGTFVDAA ASAGVDDPHQ HGRGVALADF NRDGKVDIVY GNWNGPHRLY LQMSTHGKVR 120

25 FRDIASPKFS MPSPVRTVIT ADFDNDQELE IFFNNIAYRS SSANRLFRVI RREHGDPLIE 180

ELNPGDALEP EGRGTGGWT DFDGDGMLDL ILSHGESMAQ PLSVFRGNQG FNNNWLRWP 240

RTRVGAFARG AKWLYTKKS GAHLRIIDGG SGYLCEMEPV AHFGLGKDEA SSVEVTWPDG 300

KMVSRNVASG EMNSVLEILY PRDEDTLQDP APLETPMNAS SSHSCALETS PYVSTPMEAT 360

GAGPTRSAVG ATSPTRMAQP AWGLSASHRA PAPPPPPLLL PLPLLLPLLE LPLLHRSS

30

Seq ID NO: 470 DNA sequence Nucleic Acid Accession ft: AJ279016 Coding sequence: 1..1962

35 11 21 31 41 51

ATGTCCAGGA TGTTACCGTT CCTGCTGCTG CTCTGGTTTC TGCCCATCAC TGAGGGGTCC 60 CAGCGGGCTG AACCCATGTT CACTGCAGTC ACCAACTCAG TTCTGCCTCC TGACTATGAC 120 AGTAATCCCA CCCAGCTCAA CTATGGTGTG GCAGTTACTG ATGTGGACCA TGATGGGGAC 180

40 TTTGAGATCG TCGTGGCGGG GTACAATGGA CCCAACCTGG TTCTGAAGTA TGACCGGGCC 240 CAGAAGCGGC TGGTGAACAT CGCGGTCGAT GAGCGCAGCT CACCCTACTA CGCGCTGCGG 300 GACCGGCAGG GGAACGCCAT CGGGGTCACA GCCTGCGACA TCGACGGGGA CGGCCGGGAG 360 GAGATCTACT TCCTCAACAC CAATAATGCC TTCTCGGGGG TGGCCACGTA CACCGACAAG 420 TTGTTCAAGT TCCGCAATAA CCGGTGGGAA GACATCCTGA GCGATGAGGT CAACGTGGCC 480

45 CGTGGTGTGG CCAGCCTCTT TGCCGGACGC TCTGTGGCCT GTGTGGACAG AAAGGGCTCT 540 GGACGCTACT CTATCTACAT TGCCAATTAC GCCTACGGTA ATGTGGGCCC TGATGCCCTC 600 ATTGAAATGG ACCCTGAGGC CAGTGACCTC TCCCGGGGCA TTCTGGCGCT CAGAGATGTG 660 GCTGCTGAGG CTGGGGTCAG CAAATATACA GGGGGCCGAG GCGTCAGCGT GGGCCCCATC 720 CTCAGCAGCA GTGCCTCGGA TATCTTCTGC GACAATGAGA ATGGGCCTAA CTTCCTTTTC 780

50 CACAACCGGG GCGATGGCAC CTTTGTGGAC GCTGCGGCCA GTGCTGGTGT GGACGACCCC 840 CACCAGCATG GGCGAGGTGT CGCCCTGGCT GACTTCAACC GTGATGGCAA AGTGGACATC 900 GTCTATGGCA ACTGGAATGG CCCCCACCGC CTCTATCTGC AAATGAGCAC CCATGGGAAG 960 GTCCGCTTCC GGGACATCGC CTCACCCAAG TTCTCCATGC CCTCCCCTGT CCGCACGGTC 1020 ATCACCGCCG ACTTTGACAA TGACCAGGAG CTGGAGATCT TCTTCAACAA CATTGCCTAC 1080

55 CGCAGCTCCT CAGCCAACCG CCTCTTCCGC GTCATCCGTA GAGAGCACGG AGACCCCCTC 1140 ATCGAGGAGC TCAATCCCGG CGACGCCTTG GAGCCTGAGG GCCGGGGCAC AGGGGGTGTG 1200 GTGACCGACT TCGACGGAGA CGGGATGCTG GACCTCATCT TGTCCCATGG AGAGTCCATG 1260 GCTCAGCCGC TGTCCGTCTT CCGGGGCAAT CAGGGCTTCA ACAACAACTG GCTGCGAGTG 1320 GTGCCACGCA CCCGGTTTGG GGCCTTTGCC AGGGGAGCTA AGGTCGTGCT CTACACCAAG 1380

60 AAGAGTGGGG CCCACCTGAG GATCATCGAC GGGGGCTCAG GCTACCTGTG TGAGATGGAG 1440 CCCGTGGCAC ACTTTGGCCT GGGGAAGGAT GAAGCCAGCA GTGTGGAGGT GACGTGGCCA 1500 GATGGCAAGA TGGTGAGCCG GAACGTGGCC AGCGGGGAGA TGAACTCAGT GCTGGAGATC 1560 CTCTACCCCC GGGATGAGGA CACACTTCAG GACCCAGCCC CACTGGAGTG TGGCCAAGGA 1620 TTCTCCCAGC AGGAAAATGG CCATTGCATG GACACCAATG AATGCATCCA GTTCCCATTC 1680

65 GTGTGCCCTC GAGACAAGCC CGTATGTGTC AACACCTATG GAAGCTACAG GTGCCGGACC 1740 AACAAGAAGT GCAGTCGGGG CTACGAGCCC AACGAGGATG GCACAGCCTG CGTGGGGACT 1800 CTCGGCCAGT CACCGGGCCC CCGCCCCACC ACCCCCACCG CTGCTGCTGC CACTGCCGCT 1860 GCTGCTGCCG CTGCTGGAGC TGCCACTGCT GCACCGGTCC TCGTAGATGG AGATCTCAAT 1920 CTGGGGTCGG TGGTTAAGGA GAGCTGCGAG CCCAGCTGCT GAGCAGGGGT GGGACATGAA 1980

70 CCAGCGGATG GAGTCCAGCA GGGGAGTGGG AAAGTGGGCT TGTGCTGCTG CCTAGACAGT 2040 AGGGATGTAA AGGCCTGGGA GCTAGACCCT CCCCAAGCCC ATCCATGCAC ATTACTTAGC 2100 TAACAATTAG GGAGACTCGT AAGGCCAGGC CCTGTGCTGG GCACATAGCT GTGATCACAG 2160 CAGACAGGGT CGCTGCCCTG ATGGCGCTTA CATTCCAGTG GGTCTAATGA CCATATCTTA 2220 GGACACAGAT GTGCCCAGGG AGGTGGTGTC ACTGCACAGG AAGTATGAGG ACTTTAGTGT 2280

75 CCTGAGTTCA AATCCTGATT CAGGAACTCA CAAAGCTATG TGACCTTACA CCAGTCACTT 2340 AACTTGTTAG CCATCCATTA TCGCATCTGC AAAATGGGGA TTAAGAATAG AATCTTGGGG 2400 TTAGTGTGGA GATTAGATTA AATGTATGTA AGACACTTGG CACAAAACCT GGCACATAGT 2460 AAAGGCTCAA TAAAAACAAG TGCCTCTCAC TGGGCTTTGT CAACACG

80 Seq ID NO: 471 Protein sequence Protein Accession ft: CAC08451

11 21 31 41 51 o r I I I 1 I I

OJ MSRMLPFLLL LWFLPITEGS QRAEPMFTAV TNSVLPPDYD SNPTQLNYGV AVTDVDHDGD 60

FEIWAGYNG PNLVLKYDRA QKRLVNIAVD ERSSPYYALR DRQGNAIGVT ACDIDGDGRE 120

EIYFLNTNNA FSGVATYTDK LFKFRNNRWE DILSDEVNVA RGVASLFAGR SVACVDRKGS 180 GRYSIYIANY AYGNVGPDAL IEMDPEASDL SRGILALRDV AAEAGVSKYT GGRGVSVGPI 240

LSSSASDIFC DNENGPNFLF HNRGDGTFVD AAASAGVDDP HQHGRGVALA DFNRDGKVDI 300

VYGNWNGPHR LYLQMSTHGK VRFRDIASPK FSMPSPVRTV ITADFDNDQE LEIFFNNIAY 360

RSSSANRLFR VIRREHGDPL IEELNPGDAL EPEGRGTGGV VTDFDGDGML DLILSHGESM 420

AQPLSVFRGN QGFNNNWLRV VPRTRFGAFA RGAK LYTK KSGAHLRIID GGSGYLCEME 480

PVAHFGLGKD EASSVEVTWP DGKMVSRNVA SGEMNSVLEI LYPRDEDTLQ DPAPLECGQG 540

FSQQENGHCM DTNECIQFPF VCPRDKPVCV NTYGSYRCRT NKKCSRGYEP NEDGTACVGT 600 LGQSPGPRPT TPTAAAATAA AAAAAGAATA APVLVDGDLN LGSWKESCE PSC

10 Seq ID NO: 472 DNA sequence Nucleic Acid Accession ft: FGENESHH Coding sequence: 1..4794

, _ 1 11 21 31 41 51

15 I I I I I I

ATGGCGTGTC CGGGAGGACT CCCAGCCCGT TGCTCTGGTT GGATGGGACT GGGTGGGCCC 60

AGCGGCTCCT CCCCAGCATC CCCTCCCCAT TCCTCCTCCA GGTACAATGG ACCCAACCTG 120

GTTCTGAAGT ATGACCGGGC CCAGAAGCGG CTGGTGAACA TCGCGGTCGA TGAGCGCAGC 180

TCACCCTACT ACGCGCTGCG GGACCGGCAG GGGAACGCCA TCGGGGTCAC AGCCTGCGAC 240

20 ATCGACGGGG ACGGCCGGGA GGAGATCTAC TTCCTCAACA CCAATAATGC CTTCTCGGGC 300

CACAGCAGCT CAGCGCAGGT CCCTTCTGGG CTCCACAGAA ACAGGCCTGT GCTGAAGCCT 360

CCACCTACAA CCCCTGCAGG CCTCCTGGGT CTGCCTCCAC TCAGCGGAAG GGACTTTTCC 420

TCCTCCCTGG GTCAGGCTTC TCCGGACAGC AGGCAGGGAG AGAGGGTGCC GGTTCCCTGC 480

TGTCGGGGTG GACTGAGACC TACCCATGAA CCAGAACCAT TTCTTCTGAG ACCCAAATCA 540

25 GGGGTGGCCA CGTACACCGA CAAGTTGTTC AAGTTCCGCA ATAACCGGTG GGAAGACATC 600

CTGAGCGATG AGGTCAACGT GGCCCGTGGT GTGGCCAGCC TCTTTGCCGG ACGCTCTGTG 660

GCCTGTGTGG ACAGAAAGGG CTCTGGACGC TACTCTATCT ACATTGCCAA TTACGCCTAC 720

GGTAATGTGG GCCCTGATGC CCTCATTGAA ATGGACCCTG AGGCCAGTGA CCTCTCCCGG 780

GGCATTCTGG CGCTCAGAGA TGTGGCTGCT GAGGCTGGGG TCAGCAAATA TACAGAAGGC 840

30 TTCTCCCACA CTGCCTCTCC AAGCATTGGT GAGATATCTG GCAGAACCGA GGAGCGGGAA 900

GGAGGAGACC CAGAGGAGGC AGATGAGGAG CACAGTGGGG ATGGAAGCAC CAGCCAACTG 960

TGCCGGCTGG GCTGGAAGGA CGGGCAGTTC AAGGAAGAAG CAGCAGCTTT GGTGGAGGAA 1020

CAGAGGGAGG CTGGGGCAGC TGGCGTGCCC AGAGGACGTG TTCGAACAGC TCTGCAGACT 1080

TCCAAAAGCC ATTTGGCTGA CAAGAACCTA TTTGGCCCAC CATGTTACTA TTCTGTCTGC 1140 5 GCGCCTTCTC CAGCCCACCC TTTCCCTGCC CGCCAAGCCC CCCAACACTA CCCTGTAGCC 1200

CCCCTTGTCA CTCAGCTAAT GACACATGGA CGTCTGGCTG GAAAACTAGC CCGGAGTGTC 1260

CCCCACCCCC GAGCCCCAGG AATGGACCCC AAATGTAAGG GCCGCCATGC TGAGCCCGGC 1320

CTGATGGCTG AGGCTTTGGG CGCGTGGCCA GCGCTCAGCA CCACTGTGGT GCCAGGGGGC 1380

CTGAGAAGCT GGGAGGAAAG CAGGCAGAAG GGGCAGGCCA TGTCCAGATG TGCACTCAGG 1440 0 GAGCTGGGAd GTCCCTGGAG CCAAGCCACA CAGCACCTGC CTGCTAGAGA GCTGTATGAC 1500

CTGGGAGAAC CTCCCATTTT ACAAAGAACA GACGGAGATC CAGGGAGGAG AAGGGACTCG 1560

CCCAAGGTCA CACAGGAGTG CCATCTAGTG GCCACCATGC CAGCTCTCGG GGGACTCGAG 1620

GGCCCCGGGA GGGTGGCCAA GCGAGAGATT GGGAGAGAGA CTGGGGCAGT AGGAAGACCA 1680

CTCTCCCATC CCCTGGTCCC CAACTTCCCC AGCTGCTTGA GGCCTCTTGA AGCCGGGACA 1740 5 GTGCCGGGAG CTGCCCTGCC TGGGAATCCT GGGAACTGGG TTCTGGACAT GGCCAAGGCC 1800

CTGGCGTGGA ACCAGATGGA AAAAGAGGAG GGGAAGATTC ATGGAGACCA TGAGCCCAGA 1860

TTTAGGCTCA GGAAAGCACG GGAAGCAGAA TTCCCCCCAG GCTCCTCTGA GGAGCCTCTG 1920

CTGCAGTTCC CCTCAGGCCT CAGAGGCAGC CCTGTCCTCC AGGTGGGCCT GGGGCTTGCT 1980

TCTGCCACTC ACTGTGGGTC GATGTCTTTT CTAGGGGGCC GAGGCGTCAG CGTGGGCCCC 2040 0 ATCCTCAGCA GCAGTGCCTC GGATATCTTC TGCGACAATG AGAATGGGCC TAACTTCCTT 2100

TTCCACAACC GGGGCGATGG CACCTTTGTG GACGCTGCGG CCAGTGCTGA ACGTCGTTTA 2160

GCCTTCATCG TTCACCTCAA ATATCACCTC TGCAGAGATT TTCCTCACTC CCTGTGCCAC 2220

CTAGCAGAAA CTGGTCCTTC CTCCTCCTGC TGCCCGTGGC ATGCACGTCT TCTTCAGGCT 2280

CCACATTGCC ATCATGGTTT GTCTATGAGC TTTACAAGGA CCGGGTCACG GTTCTATTCA 2340 5 TTCTTGACGC AAGGCTTGGC CTCCAGTGCC CACCGGAGGA CACTCAGCCT CCAGGGTTCT 2400

CAGGGGGCCC CACCCTGCCT TCTGGCAAGA GCTCCCTGTG TCCTGGGGTC TCTGATCCCC 2460

ACTGCCTATT ACATTGTCCT GTGGTCTGCC ATCCCAGAGA GCCTGATGAC CCACAGCTAT 2520

TTGTCCTCTG AAAGAGTCAA CGTGGGTGTG GACGACCCCC ACCAGCATGG GCGAGGTGTC 2580

GCCCTGGCTG ACTTCAACCG TGATGGCAAA GTGGACATCG TCTATGGCAA CTGGAATGGC 2640 0 CCCCACCGCC TCTATCTGCA AATGAGCACC CATGGGAAGG TCCGCTTCCG GGACATCGCC 2700

TCACCCAAGT TCTCCATGCC CTCCCCTGTC CGCACGGTCA TCACCGCCGA CTTTGACAAT 2760

GACCAGGAGC TGGAGATCTT CTTCAACAAC ATTGCCTACC GCAGCTCCTC AGCCAACCGC 2820

CTCTTCCGAT GCTCCATCCT GGCTCGTGGC TCTTCATCCT TGACAGCTGG TGGGAGGAAC 2880

GGTCAGGGAG AAGGTTTAAG AATCAGAAGG GGAGGGTTCC CAGGGCCAGG GGGTCAGGCC 2940 5 AAGGTCAACA CAGGTCCCCT GATGAAGAAA GAGAAAGGAA GGAAGGACGA GGACTGGGCA 3000

AGAGGCTGTG GGAATGCAGG GCAAAGCCTG GCCAAGGAGC CGGCCTCTGC TATTGCAGGG 3060

AAAGGGAAGG GAAATGTGGC CCAAAGTGTG CCCAGAACCC AAGCGCCACA AGATACAAAG 3120

CCACACTACC ACAAAAAGGG GCTACAGGGT CCAATCACTA CCAGGAAAAG GGGCTACGGG 3180

GTCCAATCAC TACCAGGAAA AGGGGCTACG GGGTCCAATC ACTACCAGGA AAAGGGGCTA 3240 0 CGGGGTCCAA TCACTACCAG GAAAAGGGGC TACGGGGTCC AATCACTACC AGGAAAAGGG 3300

GCTACGGGCT CCAATCACTA CCAGGAAAAG GGGCTACAGG GTCCAATCAC TACCAGGAAA 3360

AGGGGCTACG GGCTCCAATC ACTACCAGGA AAAGGGGCTA CAGGGTCCAA TCACTACCAC 3420

AGAAAGGGGC TACGGGCTCC AATCACTACC AGGAAAAGGG GCTACGGGGT CCAATCACTA 3480

CCAGGAAAAG GGGCTACAGG GTCCAATCAC TACCAGGAAA AGGGGCTACG GGGTCCAATC 3540 5 ACTACCAGGA AAAGGGGCTA CGGGCTCCAA TCACTACCAG GAAAAGGGGC TACGGGGTCC 3600

AATCACTACC AGGAAAAGGG GCTACAGGGT CCAATCACTA CCAGGAAAAG GGGCTACAGG 3660

GTCCAATCAC TACCACAGAA AGGGGCTACG GGCTCCAATC ACTACCAGGA AAAGGGGCTA 3720

CGGGGTCCAA TCACTACCAG GAAAAGGGGC TACGGGCTCC AATCACTACC AGGAAAAGAG 3780

GCTATGGGGT CCAATCACTA CCAGGAAAAG GGGCTACGGG CTCCAATCAC TACCAGGAAA 3840 0 AGGGGCTATG GGGTCCAATC ACTACCACAG AAAGGGGCTA CGGGGTCCAA CGTCATCCGT 3900

AGAGAGCACG GAGACCCCCT CATCGAGGAG CTCAATCCCG GCGACGCCTT GGAGCCTGAG 3960

GGCCGGGGCA CAGGGGGTGT GGTGACCGAC TTCGACGGAG ACGGGATGCT GGACCTCATC 4020

TTGTCCCATG GAGAGTCCAT GGCTCAGCCG CTGTCCGTCT TCCGGGGCAA TCAGGGCTTC 4080

AACAACAACT GGCTGCGAGT GGTGCCACGC ACCCGGTTTG GGGCCTTTGC CAGGGGAGCT 4140 5 AAGGTCGTGC TCTACACCAA GAAGAGTGGG GCCCACCTGA GGATCATCGA CGGGGGCTCA 4200

GGCTACCTGT GTGAGATGGA GCCCGTGGCA CACTTTGGCC TGGGGAAGGA TGAAGCCAGC 4260

AGTGTGGAGG TGACGTGGCC AGATGGCAAG ATGGTGAGCC GGAACGTGGC CAGCGGGGAG 4320 ATGAACTCAG TGCTGGAGAT CCTCTACCCC CGGGATGAGG ACACACTTCA GGACCCAGCC 4380

CCACTGGAGT GTGGCCAAGG ATTCTCCCAG CAGGAAAATG GCCATTGCAT GGACACCAAT 4440

GAATGCATCC AGTTCCCATT CGTGTGCCCT CGAGACAAGC CCGTATGTGT CAACACCTAT 4500

GGAAGCTACA GGTGCCGGAC CAACAAGAAG TGCAGTCGGG GCTACGAGCC CAACGAGGAT 4560

GGCACAGCCT GCGTGGGTAC TGAGCTAGGC TCTAGGCATA CAATGACGTG GAAACCAAGG 4620

CCCAAAAAGG AGCTGCAACT TTCCCAAGGC ATCTGCACCC CCGTCTGGTC CTTTTTCCTG 4680

CCGGGTTGCC GGCTGCTCCT CAAAAGAGCT CAGCTCCAGG CTGCTCCCAG CACCCTTCTC 4740 CAGAAAGCTC CAGGTATTCC AGAAGCCCAA GTGTATGAAC AAGATCAGGA ATAA

10 Seq ID NO: 473 Protein sequence Protein Accession ft: FGENESH predicted

1 11 21 31 41 51

, , I I I I I I

I D MACPGGLPAR CSGWMGLGGP SGSSPASPPH SSSRYNGPNL VLKYDRAQKR LVNIAVDERS 60

SPYYALRDRQ GNAIGVTACD IDGDGREEIY FLNTNNAFSG HSSSAQVPSG LHRNRPVLKP 120

PPTTPAGLLG LPPLSGRDFS SSLGQASPDS RQGERVPVPC CRGGLRPTHE PEPFLLRPKS 180

GVATYTDKLF KFRNNRWEDI LSDEVNVARG VASLFAGRSV ACVDRKGSGR YSIYIANYAY 240

GNVGPDALIE MDPEASDLSR GILALRDVAA EAGVSKYTEG FSHTASPSIG EISGRTEERE 300

20 GGDPEEADEE HSGDGSTSQL CRLGWKDGQF KEEAAALVEE QREAGAAGVP RGRVRTALQT 360

SKSHLADKNL FGPPCYYSVC APSPAHPFPA RQAPQHYPVA PLVTQLMTHG RLAGKLARSV 420

PHPRAPGMDP KCKGRHAEPG LMAEALGAWP ALSTT PGG LRSWEESRQK GQAMSRCALR 480

ELGGPWSQAT QHLPARELYD LGEPPILQRT DGDPGRRRDS PKVTQECHLV ATMPALGGLE 540

GPGRVAKREI GRETGAVGRP LSHPLVPNFP SCLRPLEAGT VPGAALPGNP GNWVLDMAKA 600 5 LAWNQMEKEE GKIHGDHEPR FRLRKAREAE FPPGSSEEPL LQFPSGLRGS PVLQVGLGLA 660

SATHCGSMSF LGGRGVSVGP ILSSSASDIF CDNENGPNFL FHNRGDGTFV DAAASAERRL 720

AFIVHLKYHL CRDFPHSLCH LAETGPSSSC CPWHARLLQA PHCHHGLSMS FTRTGSRFYS 780

. . FLTQGLASSA HRRTLSLQGS QGAPPCLLAR APCVLGSLIP TAYYIVLWSA IPESLMTHSY 840

LSSERVNVGV DDPHQHGRGV ALADFNRDGK VDIVYGNWNG PHRLYLQMST HGKVRFRDIA 900

30 SPKFSMPSPV RTVITADFDN DQELEIFFNN IAYRSSSANR LFRCSILARG SSSLTAGGRN 960

GQGEGLRIRR GGFPGPGGQA KVNTGPLMKK QKGRKDEDWA RGCGNAGQSL AKEPASAIAG 1020

KGKGNVAQSV PRTQAPQDTK PHYHKKGLQG PITTRKRGYG VQSLPGKGAT GSNHYQEKGL 1080

RGPITTRKRG YGVQSLPGKG ATGSNHYQEK GLQGPITTRK RGYGLQSLPG KGATGSNHYH 1140

RKGLRAPITT RKRGYGVQSL PGKGATGSNH YQEKGLRGPI TTRKRGYGLQ SLPGKGATGS 1200

35 NHYQEKGLQG PITTRKRGYR VQSLPQKGAT GSNHYQEKGL RGPITTRKRG YGLQSLPGKE 1260

AMGSNHYQEK GLRAPITTRK RGYGVQSLPQ KGATGSNVIR REHGDPLIEE LNPGDALEPE 1320

GRGTGGWTD FDGDGMLDLI LSHGESMAQP LSVFRGNQGF NNNWLRWPR TRFGAFARGA 1380

KWLYTKKSG AHLRIIDGGS GYLCEMEPVA HFGLGKDEAS SVEVTWPDGK MVSRNVASGE 1440

MNSVLEILYP RDEDTLQDPA PLECGQGFSQ QENGHCMDTN ECIQFPFVCP RDKPVCVNTY 1500 0 GSYRCRTNKK CSRGYEPNED GTACVGTELG SRHTMTWKPR PKKELQLSQG ICTPVWSFFL 1560 PGCRLLLKRA QLQAAPSTLL QKAPGIPEAQ VYEQDQE

Seq ID NO: 474 DNA sequence Nucleic Acid Accession ft: NM_003661.1 5 Coding sequence: 1..1152

1 11 21 31 41 51

A ITGAGTGCAC TITTTCCTTGG TIGTGGGAGTG AIGGGCAGAGG AIAGCTGGAGC GIAGGGTGCAA 60 0 CAAAACGTTC CAAGTGGGAC AGATACTGGA GATCCTCAAA GTAAGCCCCT CGGTGACTGG 120

GCTGCTGGCA CCATGGACCC AGAGAGCAGT ATCTTTATTG AGGATGCCAT TAAGTATTTC 180

AAGGAAAAAG TGAGCACACA GAATCTGCTA CTCCTGCTGA CTGATAATGA GGCCTGGAAC 240

GGATTCGTGG CTGCTGCTGA ACTGCCCAGG AATGAGGCAG ATGAGCTCCG TAAAGCTCTG 300

GACAACCTTG CAAGACAAAT GATCATGAAA GACAAAAACT GGCACGATAA AGGCCAGCAG 360 5 TACAGAAACT GGTTTCTGAA AGAGTTTCCT CGGTTGAAAA GTGAGCTTGA GGATAACATA 420

AGAAGGCTCC GTGCCCTTGC AGATGGGGTT CAGAAGGTCC ACAAAGGCAC CACCATCGCC 480

AATGTGGTGT CTGGCTCTCT CAGCATTTCC TCTGGCATCC TGACCCTCGT CGGCATGGGT 540

CTGGCACCCT TCACAGAGGG AGGCAGCCTT GTACTCTTGG AACCTGGGAT GGAGTTGGGA 600

ATCACAGCCG CTTTGACCGG GATTACCAGC AGTACCATGG ACTACGGAAA GAAGTGGTGG 660 0 ACACAAGCCC AAGCCCACGA CCTGGTCATC AAAAGCCTTG ACAAATTGAA GGAGGTGAGG 720

GAGTTTTTGG GTGAGAACAT ATCCAACTTT CTTTCCTTAG CTGGCAATAC TTACCAACTC 780

ACACGAGGCA TTGGGAAGGA CATCCGTGCC CTCAGACGAG CCAGAGCCAA TCTTCAGTCA 840

GTACCGCATG CCTCAGCCTC ACGCCCCCGG GTCACTGAGC CAATCTCAGC TGAAAGCGGT 900

GAACAGGTGG AGAGGGTTAA TGAACCCAGC ATCCTGGAAA TGAGCAGAGG AGTCAAGCTC 960 5 ACGGATGTGG CCCCTGTAAG CTTCTTTCTT GTGCTGGATG TAGTCTACCT CGTGTACGAA 1020

TCAAAGCACT TACATGAGGG GGCAAAGTCA GAGACAGCTG AGGAGCTGAA GAAGGTGGCT 1080

CAGGAGCTGG AGGAGAAGCT AAACATTCTC AACAATAATT ATAAGATTCT GCAGGCGGAC 1140 CAAGAACTGT GA 0 Seq ID NO: 475 Protein sequence Protein Accession ft: NP_003652.1

1 11 21 31 41 51 5 I I I I I I

MSALFLGVGV RAEEAGARVQ QNVPSGTDTG DPQSKPLGDW AAGTMDPESS IFIEDAIKYF 60

KEKVSTQNLL LLLTDNEAWN GFVAAAELPR NEADELRKAL DNLARQMIMK DKNWHDKGQQ 120

YRNWFLKEFP RLKSELEDNI RRLRALADGV QKVHKGTTIA NWSGSLSIS SGILTLVGMG 180

LAPFTEGGSL VLLEPGMELG ITAALTGITS STMDYGKKWW TQAQAHDLVI KSLDKLKEVR 240

EFLGENISNF LSLAGNTYQL TRGIGKDIRA LRRARANLQS VPHASASRPR VTEPISAESG 300 0 EQVERVNEPS ILEMSRGVKL TDVAPVSFFL VLDWYLVYE SKHLHEGAKS ETAEELKKVA 360 QELEEKLNIL NNNYKILQAD QEL

Seq ID NO: 476 DNA sequence

Nucleic Acid Accession ft: NM_014452.1 5 Coding sequence: 1..1968

1 11 21 31 41 51 ATGGGGACCT CTCCGAGCAG CAGCACCGCC CTCGCCTCCT GCAGCCGCAT CGCCCGCCGA 60 GCCACAGCCA CGATGATCGC GGGCTCCCTT CTCCTGCTTG GATTCCTTAG CACCACCACA 120 GCTCAGCCAG AACAGAAGGC CTCGAATCTC ATTGGCACAT ACCGCCATGT TGACCGTGCC 180 ACCGGCCAGG TGCTAACCTG TGACAAGTGT CCAGCAGGAA CCTATGTCTC TGAGCATTGT ^• 240 ACCAACACAA GCCTGCGCGT CTGCAGCAGT TGCCCTGTGG GGACCTTTAC CAGGCATGAG 300 AATGGCATAG AGAAATGCCA TGACTGTAGT CAGCCATGCC CATGGCCAAT GATTGAGAAA ^'•;' 360 TTACCTTGTG CTGCCTTGAC TGACCGAGAA TGCACTTGCC CACCTGGCAT GTTCCAGTCT 420 AACGCTACCT GTGCCCCCCA TACGGTGTGT CCTGTGGGTT GGGGTGTGCG GAAGAAAGGG 480 ACAGAGACTG AGGATGTGCG GTGTAAGCAG TGTGCTCGGG GTACCTTCTC AGATGTGCCT 540 TCTAGTGTGA TGAAATGCAA AGCATACACA GACTGTCTGA GTCAGAACCT GGTGGTGATC 600 AAGCCGGGGA CCAAGGAGAC AGACAACGTC TGTGGCACAC TCCCGTCCTT CTCCAGCTCC 660 ACCTCACCTT CCCCTGGCAC AGCCATCTTT CCACGCCCTG AGCACATGGA AACCCATGAA 720 GTCCCTTCCT CCACTTATGT TCCCAAAGGC ATGAACTCAA CAGAATCCAA CTCTTCTGCC 780 TCTGTTAGAC CAAAGGTACT GAGTAGCATC CAGGAAGGGA CAGTCCCTGA CAACACAAGC 840 TCAGCAAGGG GGAAGGAAGA CGTGAACAAG ACCCTCCCAA ACCTTCAGGT AGTCAACCAC 900 CAGCAAGGCC CCCACCACAG ACACATCCTG AAGCTGCTGC CGTCCATGGA GGCCACTGGG 960 GGCGAGAAGT CCAGCACGCC CATCAAGGGC CCCAAGAGGG GACATCCTAG ACAGAACCTA 1020 CACAAGCATT TTGACATCAA TGAGCATTTG CCCTGGATGA TTGTGCTTTT CCTGCTGCTG 1080 GTGCTTGTGG TGATTGTGGT GTGCAGTATC CGGAAAAGCT CGAGGACTCT GAAAAAGGGG 1140 CCCCGGCAGG ATCCCAGTGC CATTGTGGAA AAGGCAGGGC TGAAGAAATC CATGACTCCA 1200 ACCCAGAACC GGGAGAAATG GATCTACTAC TGCAATGGCC ATGGTATCGA TATCCTGAAG 1260 CTTCTAGCAG CCCAAGTGGG AAGCCAGTGG AAAGATATCT ATCAGTTTCT TTGCAATGCC 1320 AGTGAGAGGG AGGTTGCTGC TTTCTCCAAT GGGTACACAG CCGACCACGA GCGGGCCTAC 1380 GCAGCTCTGC AGCACTGGAC CATCCGGGGC CCCGAGGCCA GCCTCGCCCA GCTAATTAGC 1440 GCCCTGCGCC AGCACCGGAG AAACGATGTT GTGGAGAAGA TTCGTGGGCT GATGGAAGAC 1500 ACCACCCAGC TGGAAACTGA CAAACTAGCT CTCCCGATGA GCCCCAGCCC GCTTAGCCCG 1560 AGCCCCATCC CCAGCCCCAA CGCGAAACTT GAGAATTCCG CTCTCCTGAC GGTGGAGCCT 1620 TCCCCACAGG ACAAGAACAA GGGCTTCTTC GTGGATGAGT CGGAGCCCCT TCTCCGCTGT 1680 GACTCTACAT CCAGCGGCTC CTCCGCGCTG AGCAGGAACG GTTCCTTTAT TACCAAAGAA 1740 AAGAAGGACA CAGTGTTGCG GCAGGTACGC CTGGACCCCT GTGACTTGCA GCCTATCTTT 1800 GATGACATGC TCCACTTTCT AAATCCTGAG GAGCTGCGGG TGATTGAAGA GATTCCCCAG 1860 GCTGAGGACA AACTAGACCG GCTATTCGAA ATTATTGGAG TCAAGAGCCA GGAAGCCAGC 1920 CAGACCCTCC TGGACTCTGT TTATAGCCAT CTTCCTGACC TGCTGTAG

Seq ID NO: 477 Protein sequence Protein Accession ft: NP 055267.1

11 21 31 41 51

MGTSPSSSTA L IASCSRIARR A ITATMIAGSL L ILLGFLSTTT A IQPEQKASNL I IGTYRHVDRA 60 TGQVLTCDKC PAGTYVSEHC TNTSLRVCSS CPVGTFTRHE NGIEKCHDCS QPCPWPMIEK 120 LPCAALTDRE CTCPPGMFQS NATCAPHTVC PVGWGVRKKG TETEDVRCKQ CARGTFSDVP 180 SSVMKCKAYT DCLSQNLWI KPGTKETDNV CGTLPSFSSS TSPSPGTAIF PRPEHMETHE 240 VPSSTYVPKG MNSTESNSSA SVRPKVLSSI QEGTVPDNTS SARGKEDVNK TLPNLQWNH 300 QQGPHHRHIL KLLPSMEATG GEKSSTPIKG PKRGHPRQNL HKHFDINEHL PWMIVLFLLL 360 VLWIWCSI RKSSRTLKKG PRQDPSAIVE KAGLKKSMTP TQNREKWIYY CNGHGIDILK 420 LVAAQVGSQW KDIYQFLCNA SEREVAAFSN GYTADHERAY AALQHWTIRG PEASLAQLIS 480 ALRQHRRNDV VEKIRGLMED TTQLETDKLA LPMSPSPLSP SPIPSPNAKL ENSALLTVEP 540 SPQDKNKGFF VDESEPLLRC DSTSSGSSAL SRNGSFITKE KKDTVLRQVR LDPCDLQPIF 600 DDMLHFLNPE ELRVIEEIPQ AEDKLDRLFE IIGVKSQEAS QTLLDSVYSH LPDLL

Seq ID NO: 478 DNA sequence Nucleic Acid Accession ft: XM_044533 Coding sequence: 238..2751

11 21 31 41 51

GCTCTGCCCA AGCCGAGGCT GCGGGGCCGG CGCCGGCGGG AGGACTGCGG TGCCCCGCGG 60 AGGGGCTGAG TTTGCCAGGG CCCACTTGAC CCTGTTTCCC ACCTCCCGCC CCCCAGGTCC 120 GGAGGCGGGG GCCCCCGGGG CGACTCGGGG GCGGACCGCG GGGCGGAGCT GCCGCCCGTG 180 AGTCCGGCCG AGCCACCTGA GCCCGAGCCG CGGGACACCG TCGCTCCTGC TCTCCGAATG 240 CTGCGCACCG CGATGGGCCT GAGGAGCTGG CTCGCCGCCC CATGGGGCGC GCTGCCGCCT 300 CGGCCACCGC TGCTGCTGCT CCTGCTGCTG CTGCTCCTGC TGCAGCCGCC GCCTCCGACC 360 TGGGCGCTCA GCCCCCGGAT CAGCCTGCCT CTGGGCTCTG AAGAGCGGCC ATTCCTCAGA 420 TTCGAAGCTG AACACATCTC CAACTACACA GCCCTTCTGC TGAGCAGGGA TGGCAGGACC 480 CTGTACGTGG GTGCTCGAGA GGCCCTCTTT GCACTCAGTA GCAACCTCAG CTTCCTGCCA 540 GGCGGGGAGT ACCAGGAGCT GCTTTGGGGT GCAGACGCAG AGAAGAAACA GCAGTGCAGC 600 TTCAAGGGCA AGGACCCACA GCGCGACTGT CAAAACTACA TCAAGATCCT CCTGCCGCTC 660 AGCGGCAGTC ACCTGTTCAC CTGTGGCACA GCAGCCTTCA GCCCCATGTG TACCTACATC 720 AACATGGAGA ACTTCACCCT GGCAAGGGAC GAGAAGGGGA ATGTCCTCCT GGAAGATGGC 780 AAGGGCCGTT GTCCCTTCGA CCCGAATTTC AAGTCCACTG CCCTGGTGGT TGATGGCGAG 840 CTCTACACTG GAACAGTCAG CAGCTTCCAA GGGAATGACC CGGCCATCTC GCGGAGCCAA 900 AGCCTTCGCC CCACCAAGAC CGAGAGCTCC CTCAACTGGC TGCAAGACCC AGCTTTTGTG 960 GCCTCAGCCT ACATTCCTGA GAGCCTGGGC AGCTTGCAAG GCGATGATGA CAAGATCTAC 1020 TTTTTCTTCA GCGAGACTGG CCAGGAATTT GAGTTCTTTG AGAACACCAT TGTGTCCCGC 1080 ATTGCCCGCA TCTGCAAGGG CGATGAGGGT GGAGAGCGGG TGCTACAGCA GCGCTGGACC 1140 TCCTTCCTCA AGGCCCAGCT GCTGTGCTCA CGGCCCGACG ATGGCTTCCC CTTCAACGTG 1200 CTGCAGGATG TCTTCACGCT GAGCCCCAGC CCCCAGGACT GGCGTGACAC CCTTTTCTAT 1260 GGGGTCTTCA CTTCCCAGTG GCACAGGGGA ACTACAGAAG GCTCTGCCGT CTGTGTCTTC 1320 ACAATGAAGG ATGTGCAGAG AGTCTTCAGC GGCCTCTACA AGGAGGTGAA CCGTGAGACA 1380 CAGCAGTGGT ACACCGTGAC CCACCCGGTG CCCACACCCC GGCCTGGAGC GTGCATCACC 1440 AACAGTGCCC GGGAAAGGAA GATCAACTCA TCCCTGCAGC TCCCAGACCG CGTGCTGAAC 1500 TTCCTCAAGG ACCACTTCCT GATGGACGGG CAGGTCCGAA GCCGCATGCT GCTGCTGCAG 1560 CCCCAGGCTC GCTACCAGCG CGTGGCTGTA CACCGCGTCC CTGGCCTGCA CCACACCTAC 1620 GATGTCCTCT TCCTGGGCAC TGGTGACGGC CGGCTCCACA AGGCAGTGAG CGTGGGCCCC 1680 CGGGTGCACA TCATTGAGGA GCTGGAGATC TTCTCATCGG GACAGCCCGT GCAGAATCTG 1740 CTCCTGGACA CCCACAGGGG GCTGCTGTAT GCGGCCTCAC ACTCGGGCGT AGTCCAGGTG 1800

CCCATGGCCA ACTGCAGCCT GTACAGGAGC TGTGGGGACT GCCTCCTCGC CCGGGACCCC 1860

TACTGTGCTT GGAGCGGCTC CAGCTGCAAG CACGTCAGCC TCTACCAGCC TCAGCTGGCC 1920

ACCAGGCCGT GGATCCAGGA CATCGAGGGA GCCAGCGCCA AGGACCTTTG CAGCGCGTCT 1980 TCGGTTGTGT CCCCGTCTTT TGTACCAACA GGGGAGAAGC CATGTGAGCA AGTCCAGTTC 2040

CAGCCCAACA CAGTGAACAC TTTGGCCTGC CCGCTCCTCT CCAACCTGGC GACCCGACTC 2100

TGGCTACGCA ACGGGGCCCC CGTCAATGCC TCGGCCTCCT GCCACGTGCT ACCCACTGGG 2160

GACCTGCTGC TGGTGGGCAC CCAACAGCTG GGGGAGTTCC AGTGCTGGTC ACTAGAGGAG 2220

GGCTTCCAGC AGCTGGTAGC CAGCTACTGC CCAGAGGTGG TGGAGGACGG GGTGGCAGAC 2280 CAAACAGATG AGGGTGGCAG TGTACCCGTC ATTATCAGCA CATCGCGTGT GAGTGCACCA 2340

GCTGGTGGCA AGGCCAGCTG GGGTGCAGAC AGGTCCTACT GGAAGGAGTT CCTGGTGATG 2400

TGCACGCTCT TTGTGCTGGC CGTGCTGCTC CCAGTTTTAT TCTTGCTCTA CCGGCACCGG 2460

AACAGCATGA AAGTCTTCCT GAAGCAGGGG GAATGTGCCA GCGTGCACCC CAAGACCTGC 2520

CCTGTGGTGC TGCCCCCTGA GACCCGCCCA CTCAACGGCC TAGGGCCCCC TAGCACCCCG 2580 CTCGATCACC GAGGGTACCA GTCCCTGTCA GACAGCCCCC CGGGGTCCCG AGTCTTCACT 2640

GAGTCAGAGA AGAGGCCACT CAGCATCCAA GACAGCTTCG TGGAGGTATC CCCAGTGTGC 2700

CCCCGGCCCC GGGTCCGCCT TGGCTCGGAG ATCCGTGACT CTGTGGTGTG AGAGCTGACT 2760

TCCAGAGGAC GCTGCCCTGG CTTCAGGGGC TGTGAATGCT CGGAGAGGGT CAACTGGACC 2820

TCCCCTCCGC TCTGCTCTTC GTGGAACACG ACCGTGGTGC CCGGCCCTTG GGAGCCTTGG 2880 GGCCAGCTGG CCTGCTGCTC TCCAGTCAAG TAGCGAAGCT CCTACCACCC AGACACCCAA 2940

ACAGCCGTGG CCCCAGAGGT CCTGGCCAAA TATGGGGGCC TGCCTAGGTT GGTGGAACAG 3000

TGCTCCTTAT GTAAACTGAG CCCTTTGTTT AAAAAACAAT TCCAAATGTG AAACTAGAAT 3060

GAGAGGGAAG AGATAGCATG GCATGCAGCA CACACGGCTG CTCCAGTTCA TGGCCTCCCA 3120

GGGGTGCTGG GGATGCATCC AAAGTGGTTG TCTGAGACAG AGTTGGAAAC CCTCACCAAC 3180 TGGCCTCTTC ACCTTCCACA TTATCCCGCT GCCACCGGCT GCCCTGTCTC ACTGCAGATT 32^*40

CAGGACCAGC TTGGGCTGCG TGCGTTCTGC CTTGCCAGTC AGCCGAGGAT GTAGTTGTTG 3300

CTGCCGTCGT CCCACCACCT CAGGGACCAG AGGGCTAGGT TGGCACTGCG GCCCTCACCA 3360

GGTCCTGGGC TCGGACCCAA CTCCTGGACC TTTCCAGCCT GTATCAGGCT GTGGCCACAC 3420

GAGAGGACAG CGCGAGCTCA GGAGAGATTT CGTGACAATG TACGCCTTTC CCTCAGAATT 3480 CAGGGAAGAG ACTGTCGCCT GCCTTCCTCC GTTGTTGCGT GAGAACCCGT GTGCCCCTTC 3540

CCACCATATC CACCCTCGCT CCATCTTTGA ACTCAAACAC GAGGAACTAA CTGCACCCTG 3600

GTCCTCTCCC CAGTCCCCAG TTCACCCTCC ATCCCTCACC TTCCTCCACT CTAAGGGATA 3660

TCAACACTGC CCAGCACAGG GGCCCTGAAT TTATGTGGTT TTTATACATT TTTTAATAAG 3720

ATGCACTTTA TGTCATTTTT TAATAAAGTC TGAAGAATTA CTGTTT

Seq ID NO: 479 Protein sequence Protein Accession ft: XP 044533.3

1 11 21 31 41 51 i i i i i I

MLRTAMGLRS WLAAPWGALP PRPPLLLLLL LLLLLQPPPP TWALSPRISL PLGSEERPFL 60

RFEAEHISNY TALLLSRDGR TLYVGAREAL FALSSNLSFL PGGEYQELLW GADAEKKQQC 120

SFKGKDPQRD CQNYIKILLP LSGSHLFTCG TAAFSPMCTY INMENFTLAR DEKGNVLLED 180

GKGRCPFDPN FKSTALWDG ELYTGTVSSF QGNDPAISRS QSLRPTKTES SLNWLQDPAF 240 VASAYIPESL GSLQGDDDKI YFFFSETGQE FEFFENTIVS RIARICKGDE GGERVLQQRW 300

TSFLKAQLLC SRPDDGFPFN VLQDVFTLSP SPQDWRDTLF YGVFTSQWHR GTTEGSAVCV 360

FTMKDVQRVF SGLYKEVNRE TQQWYTVTHP VPTPRPGACI TNSARERKIN SSLQLPDRVL 420

NFLKDHFLMD GQVRSRMLLL QPQARYQRVA VHRVPGLHHT YDVLFLGTGD GRLHKAVSVG 480

PRVHIIEELQ IFSSGQPVQN LLLDTHRGLL YAASHSGWQ VPMANCSLYR SCGDCLLARD 540 PYCAWSGSSC KHVSLYQPQL ATRPWIQDIE GASAKDLCSA SSWSPSFVP TGEKPCEQVQ 600

FQPNTVNTLA CPLLSNLATR LWLRNGAPVN ASASCHVLPT GDLLLVGTQQ LGEFQCWSLE 660

EGFQQLVASY CPE EDGVA DQTDEGGSVP VIISTSRVSA PAGGKASWGA DRSYWKEFLV 720

MCTLFVLAVL LPVLFLLYRH RNSMKVFLKQ GECASVHPKT CPWLPPETR PLNGLGPPST 780 PLDHRGYQSL SDSPPGSRVF TESEKRPLSI QDSFVEVSPV CPRPRVRLGS EIRDSW

Seq ID NO: 480 DNA sequence

Nucleic Acid Accession ft: NM_004217.1

Coding sequence: 58..1092

1 11 21 31 41 51

I I I I I I

GGCCGGGAGA GTAGCAGTGC CTTGGACCCC AGCTCTCCTC CCCCTTTCTC TCTAAGGATG 60

GCCCAGAAGG AGAACTCCTA CCCCTGGCCC TACGGCCGAC AGACGGCTCC ATCTGGCCTG 120

AGCACCCTGC CCCAGCGAGT CCTCCGGAAA GAGCCTGTCA CCCCATCTGC ACTTGTCCTC 180 ATGAGCCGCT CCAATGTCCA GCCCACAGCT GCCCCTGGCC AGAAGCTGAT GGAGAATAGC 2 0

AGTGGGACAC CCGACATCTT AACGCGGCAC TTCACAATTG ATGACTTTGA GATTGGGCGT 300

CCTCTGGGCA AAGGCAAGTT TGGAAACGTG TACTTGGCTC GGGAGAAGAA AAGCCATTTC 360

ATCGTGGCGC TCAAGGTCCT CTTCAAGTCC CAGATAGAGA AGGAGGGCGT GGAGCATCAG 420

CTGCGCAGAG AGATCGAAAT CCAGGCCCAC CTGCACCATC CCAACATCCT GCGTCTCTAC 480 AACTATTTTT ATGACCGGAG GAGGATCTAC TTGATTCTAG AGTATGCCCC CCGCGGGGAG 540

CTCTACAAGG AGCTGCAGAA GAGCTGCACA TTTGACGAGC AGCGAACAGC CACGATCATG 600

GAGGAGTTGG CAGATGCTCT AATGTACTGC CATGGGAAGA AGGTGATTCA CAGAGACATA 660

AAGCCAGAAA ATCTGCTCTT AGGGCTCAAG GGAGAGCTGA AGATTGCTGA CTTCGGCTGG 720

TCTGTGCATG CGCCCTCCCT GAGGAGGAAG ACAATGTGTG GCACCCTGGA CTACCTGCCC 780 CCAGAGATGA TTGAGGGGCG CATGCACAAT GAGAAGGTGG ATCTGTGGTG CATTGGAGTG 840

CTTTGCTATG AGCTGCTGGT GGGGAACCCA CCCTTTGAGA GTGCATCACA CAACGAGACC 900

TATCGCCGCA TCGTCAAGGT GGACCTAAAG TTCCCCGCTT CTGTGCCCAC GGGAGCCCAG 960

GACCTCATCT CCAAACTGCT CAGGCATAAC CCCTCGGAAC GGCTGCCCCT GGCCCAGGTC 1020

TCAGCCCACC CTTGGGTCCG GGCCAACTCT CGGAGGGTGC TGCCTCCCTC TGCCCTTCAA 1080 TCTGTCGCCT GATGGTCCCT GTCATTCACT CGGGTGCGTG TGTTTGTATG TCTGTGTATG 1140

TATAGGGGAA AGAAGGGATC CCTAACTGTT CCCTTATCTG TTTTCTACCT CCTCCTTTGT 1200 TTAATAAAGG CTGAAGCTTT TTGT

Seq ID NO: 481 Protein sequence Protein Accession ft: NP_004208

1 11 21 31 41 51 I I I I I I

MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT AAPGQKVMEN 60

SSGTPDILTR HFTIDDFEIG RPLGKGKFGN VYLAREKKSH FIVALKVLFK SQIEKEGVEH 120

QLRREIEIQA HLHHPNILRL YNYFYDRRRI YLILEYAPRG ELYKELQKSC TFDEQRTATI 180 MEELADALMY CHGKKVIHRD IKPENLLLGL KGELKIADFG WSVHAPSLRR KTMCGTLDYL 240

PPEMIEGRMH NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPASVPTGA 300 QDLISKLLRH NPSERLPLAQ VSAHPWVRAN SRRVLPPSAL QSVA Seq ID NO: 482 DNA sequence Nucleic Acid Accession #: AK055663 Coding sequence: 38..1423

1 11 21 31 41 51

I I I I I I

AGAACGGCTT CCGGCGGGAG CTGTGCAGCT CCTTATCATG GGGACAATTC ATCTCTTTCG 60

AAAACCACAA AGATCCTTTT TTGGCAAGTT GTTACGGGAA TTTAGACTTG TAGCAGCTGA 120

CCGAAGGTCC TGGAAGATAC TGCTCTTTGG TGTAATAAAC TTGATATGTA CTGGCTTCCT 180

GCTTATGTGG TGCAGTTCTA CTAATAGTAT AGCTTTAACT GCCTATACTT ACCTGACCAT 240

TTTTGATCTT TTTAGTTTAA TGACATGTTT AATAAGTTAC TGGGTAACAT TGAGGAAACC 300

TAGCCCTGTC TATTCATTTG GGTTTGAAAG ATTAGAAGTC CTGGCTGTAT TTGCCTCCAC 360

AGTCTTGGCA CAGTTGGGAG CTCTCTTTAT ATTAAAAGAA AGTGCAGAAC GCTTTTTGGA 420

ACAGCCCGAG ATACACACGG GAAGATTATT AGTTGGTACT TTTGTGGCTC TTTGTTTCAA 480

CCTGTTCACG ATGCTTTCTA TTCGGAATAA ACCTTTTGCT TATGTCTCAG AAGCTGCTAG 540

TACGAGCTGG CTTCAAGAGC ATGTTGCAGA TCTTAGTCGA AGCTTGTGTG GAATTATTCC 600

GGGACTTAGC AGTATCTTCC TTCCCCGAAT GAATCCATTT GTTTTGATTG ATCTTGCTGG 660

AGCATTTGCT CTTTGTATTA CATATATGCT CATTGAAATT AATAATTATT TTGCCGTAGA 720

CACTGCCTCT GCTATAGCTA TTGCCTTGAT GACATTTGGC ACTATGTATC CCATGAGTGT 780

GTACAGTGGG AAAGTCTTAC TCCAGACAAC ACCACCCCAT GTTATTGGTC AGTTGGACAA 840

ACTCATCAGA GAGGTATCTA CCTTAGATGG AGTTTTAGAA GTCCGAAATG AACATTTTTG 900

GACCCTAGGT TTTGGCTCAT TGGCTGGATC AGTGCATGTA AGAATTCGAC GAGATGCCAA 960

TGAACAAATG GTTCTTGCTC ATGTGACCAA CAGGCTGTAC ACTCTAGTGT CTACTCTAAC 1020

TGTTCAAATT TTCAAGGATG ACTGGATTAG GCCTGCCTTA TTGTCTGGGC CTGTTGCAGC 1080

CAATGTCCTA AACTTTTCAG ATCATCACGT AATCCCAATG CCTCTTTTAA AGGGTACTGA 1140

TGATTTGAAC CCAGTTACAT CAACTCCAGC TAAACCTAGT AGTCCACCTC CAGAATTTTC 1200

ATTTAACACT CCTGGGAAAA ATGTGAACCC AGTTATTCTT CTAAACACAC AAACAAGGCC 1260

TTATGGTTTT GGTCTCAATC ATGGACACAC ACCTTACAGC AGCATGCTTA ATCAAGGACT 1320

TGGAGTTCCA GGAATTGGAG CAACTCAAGG ATTGAGGACT GGTTTTACAA ATATACCAAG 1380

TAGATATGGA ACTAATAATA GAATTGGACA ACCAAGACCA TGATAGACTC TAACTTATTT 1440

TTATAAGGAA TATTGACTCC TTGGCTTCCA ATTTATTTAG TAATCCAACT TTGCATTGAC 1500

TGTTTAATCA TTTACTCTAA ATGTTAGATA ATAGTAGTCT TGTTCACATT TCATGAAACC 1560

TATGAAACTA TATTTTTGTA AAATGTATTT GTGACAGTGA AATCCTCGTA AATGTTAAAG 1620

GCTTTAAATA GGCTTCCTTT AGAAAATGTG TTTCTTTAAA TTTGGATTTT GGTATCTTTG 1680

GTTTTGTAGT TGACTGCAGT GTGATGTGAC CTTACCTTTA TAAGAGCCAC TTGATGGAGT 1740

AGATCTGTCA CATTACTAAG ATACGATATT TCTTTTTTTT TCCGAGACGG AGTCTTGCTC 1800

TGCCACTGTG CCCGGCCAAT ACATTATTAT TAACTTAAGG CTGTACTTTA TTAAGGCTTC 1860

CTTAGTTTTT GTTTTGTTTT GTTTTTTGAG ATGGAGTCTC ACTCTGTCGC CCAGGCTGGA 1920

ATGCAGTGGC ATGATCTCAG CTCACTGCAA CCTCTGCCTC CTGAGTTCAA ATGATTCTCC 1980

TGCCTCAGCC TCCCGAGTAG CTGGGATTAC AGGCACCTGC CACCACGCCC AGCTAATTTT 2040

TGTATTTTTA GTAAAGACGG GGGATTTCAC CATGTTGGCC AGGCTGGTCT TGAACTCCTG 2100

ACCTCATGAT CCACCCACCT TAGCCTCCCA AAGTGCTGGG ATTAGGTGTG AGCCACCGCA 2160

CCTGGCCGAT ATTTTCTTTA ATGAAATTTA TAAATATGCT TCTTGAATAA TACACATTTT 2220

GGGAAAGGGA AAAATGTCTG TTCAAAAAGT AAAGGTCTCT TTTATAGCTT TTCCAAACTT 2280

AATTGCTAAA TTTTTCTTTG AGGTTCTCCT GAATTATGTC TTACAAACTA AAAGCAAAAA 2340

TTTTTAGCAG AAATTTTGGA ATACATTCTA TCTAGCACAA TTTGAATTTT TAATTATCAA 2400 GATTTTTGTT AAAGTTTCTC TCCTTTAAAA ATTTTAGTAC ATTTGTAAAT

Seq ID NO: 483 Protein sequence Protein Accession ft: BAB70980.1

1 11 21 31 41 51

I I I I I I

MGTIHLFRKP QRSFFGKLLR EFRLVAADRR SWKILLFGVI NLICTGFLLM WCSSTNSIAL 60

TAYTYLTIFD LFSLMTCLIS YWVTLRKPSP VYSFGFERLE VLAVFASTVL AQLGALFILK 120

ESAERFLEQP EIHTGRLLVG TFVALCFNLF TMLSIRNKPF AYVSEAASTS WLQEHVADLS 180

RSLCGIIPGL SSIFLPRMNP FVLIDLAGAF ALCITYMLIE INNYFAVDTA SAIAIALMTF 240

GTMYPMSVYS GKVLLQTTPP HVIGQLDKLI REVSTLDGVL EVRNEHFWTL GFGSLAGSVH 300

VRIRRDANEQ MVLAHVTNRL YTLVSTLTVQ IFKDDWIRPA LLSGPVAANV LNFSDHHVIP 360

MPLLKGTDDL NPVTSTPAKP SSPPPEFSFN TPGKNVNPVI LLNTQTRPYG FGLNHGHTPY 420 SSMLNQGLGV PGIGATQGLR TGFTNIPSRY GTNNRIGQPR P

Seq ID NO: 484 DNA sequence

Nucleic Acid Accession ft: FGENESH predicted

Coding sequence: 1..900

1 11 21 31 41 51

A ITGCCGCCGC GIGGAGCTGAG CIGAGGCCGAG CICGCCCCCGC TICCGGGCCCC GIACCCCTCCC 60

CCGCGGCGGC GTAGCGCGCC CCCAGAGCTG GGCATCAAGT GCGTGCTGGT GGGCGACGGC 120

GCCGTGGGCA AGAGCAGCCT CATCGTCAGC TACACCTGCA ATGGGTACCC CGCGCGCTAC 180

CGGCCCACTG CGCTGGACAC CTTCTCTGGT ACGTACGTTC AATCGCCCGT GCGGCCGCGT 240

GGCTGCGGCG GGGCTGTGCA CCGGGGAGCT GGGGCGGGCG TCTCGGCGGG AGGGCGCAGA 300

GGACCCCGGG GAGGAGACTG GAGCAGGCCC CGAGGTGGCG CTGGTGCGGC CCAGGACGCT 360

CTTCCTAACT CAGGCTCTCC CCGCCCCGCC CCTGCAGTGC AAGTCCTGGT GGATGGAGCT 420

CCGGTGCGCA TTGAGCTCTG GGACACAGCG GGACAGGAGG ATTTTGACCG ACTTCGTTCC 480

CTTTGCTACC CGGATACCGA TGTCTTCCTG GCGTGCTTCA GCGTGGTGCA GCCCAGCTCC 540

TTTCAAAACA TCACAGAGAA ATGGCTGCCC GAGATCCGCA CGCACAACCC CCAGGCGCCT 600

GTGCTGCTGG TGGGCACCCA GGCGGACCTG AGGGACGATG TCAACGTACT AATTCAGCTG 660 GACCAGGGGG GCCGGGAGGG CCCCGTGCCC CAACCCCAGG CTCAGGGTCT GGCCGAGAAG 720

ATCCGAGCCT GCTGCTACCT TGAGTGCTCA GCCTTGACGC AGAAGAACTT GAAGGAAGTA 780

TTTGACTCGG CTATTCTCAG TGCCATTGAG CACAAAGCCC GGCTGGAGAA GAAACTGAAT 840 GCCAAAGGTG TGCGCACCCT CTCCCGCTGC CGCTGGAAGA AGTTCTTCTG CTTCGTTTGA

Seq ID NO: 485 Protein sequence Protein Accession ft: FGENESH predicted 1 11 21 31 41 51 i i i i i i

MPPRELSEAE PPPLRAPTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS YTCNGYPARY 60

RPTALDTFSG TYVQSPVRPR GCGGAVHRGA GAGVSAGGRR GPRGGDWSRP RGGAGAAQDA 120

LPNSGSPRPA PAVQVLVDGA PVRIELWDTA GQEDFDRLRS LCYPDTDVFL ACFSWQPSS 180

FQNITEKWLP EIRTHNPQAP VLLVGTQADL RDDVNVLIQL DQGGREGPVP QPQAQGLAEK 240 IRACCYLECS ALTQKNLKEV FDSAILSAIE HKARLEKKLN AKGVRTLSRC RWKKFFCFV

Seq ID NO: 486 DNA sequence

Nucleic Acid Accession ft: XM_063832.2

Coding sequence: 1..711

1 11 21 31 41 51

I I I I I I

ATGCCGCCGC GGGAGCTGAG CGAGGCCGAG CCGCCCCCGC TCCGGGCCCC GAGCCCTCCC 60

CCGCGGCGGC GTAGCGCGCC CCCAGAGCTG GGCATCAAGT GCGTGCTGGT GGGCGACGGC 120

GCCGTGGGCA AGAGCAGCCT CATCGTCAGC TACACCTGCA ATGGGTACCC CGCGCGCTAC 180

CGGCCCACTG CGCTGGACAC CTTCTCTGTG CAAGTCCTGG TGGATGGAGC TCCGGTGCGC 240

ATTGAGCTCT GGGACACAGC GGGACAGGAG GATTTTGACC GACTTCGTTC CCTTTGCTAC 300

CCGGATACCG ATGTCTTCCT GGCGTGCTTC AGCGTGGTGC AGCCCAGCTC CTTTCAAAAC 360

ATCACAGAGA AATGGCTGCC CGAGATCCGC ACGCACAACC CCCAGGCGCC TGTGCTGCTG 420

GTGGGCACCC AGGCCGACCT GAGGGACGAT GTCAACGTAC TAATTCAGCT GGACCAGGGG 480

GGCCGGGAGG GCCCCGTGCC CCAACCCCAG GCTCAGGGTC TGGCCGAGAA GATCCGAGCC 540

TGCTGCTACC TTGAGTGCTC AGCCTTGACG CAGAAGAACT TGAAGGAAGT ATTTGACTCG 600

GCTATTCTCA GTGCCATTGA GCACAAAGCC CGGCTGGAGA AGAAACTGAA TGCCAAAGGT 660 GTGCGCACCC TCTCCCGCTG CCGCTGGAAG AAGTTCTTCT GCTTCGTTTG A

Seq ID NO: 487 Protein sequence Protein Accession ft: XP_063832.1

1 11 21 31 41 51

I I I I I I

MPPRELSEAE PPPLRAPTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS YTCNGYPARY 60

RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY PDTDVFLACF S QPSSFQN 120

ITEKWLPEIR THNPQAPVLL VGTQADLRDD VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA 180 CCYLECSALT QKNLKEVFDS AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV

Seq ID NO: 488 DNA sequence

Nucleic Acid Accession ft: NM_014398.1

Coding sequence: 64..1314

1 11 21 31 41 51

I I I I I I

GGCACCGATT CGGGGCCTGC CCGGACTTCG CCGCACGCTG CAGAACCTCG CCCAGCGCCC 60

ACCATGCCCC GGCAGCTCAG CGCGGCGGCC GCGCTCTTCG CGTCCCTGGC CGTAATTTTG 120

CACGATGGCA GTCAAATGAG AGCAAAAGCA TTTCCAGAAA CCAGAGATTA TTCTCAACCT 180

ACTGCAGCAG CAACAGTACA GGACATAAAA AAACCTGTCC AGCAACCAGC TAAGCAAGCA 240

CCTCACCAAA CTTTAGCAGC AAGATTCATG GATGGTCATA TCACCTTTCA AACAGCGGCC 300

ACAGTAAAAA TTCCAACAAC TACCCCAGCA ACTACAAAAA ACACTGCAAC CACCAGCCCA 360

ATTACCTACA CCCTGGTCAC AACCCAGGCC ACACCCAACA ACTCACACAC AGCTCCTCCA 420

GTTACTGAAG TTACAGTCGG CCCTAGCTTA GCCCCTTATT CACTGCCACC CACCATCACC 480

CCACCAGCTC ATACAGCTGG AACCAGTTCA TCAACCGTCA GCCACACAAC TGGGAACACC 540

ACTCAACCCA GTAACCAGAC CACCCTTCCA GCAACTTTAT CGATAGCACT GCACAAAAGC 600

ACAACCGGTC AGAAGCCTGA TCAACCCACC CATGCCCCAG GAACAACGGC AGCTGCCCAC 660

AATACCACCC GCACAGCTGC ACCTGCCTCC ACGGTTCCTG GGCCCACCCT TGCACCTCAG 720

CCATCGTCAG TCAAGACTGG AATTTATCAG GTTCTAAACG GAAGCAGACT CTGTATAAAA 780

GCAGAGATGG GGATACAGCT GATTGTTCAA GACAAGGAGT CGGTTTTTTC ACCTCGGAGA 840

TACTTCAACA TCGACCCCAA CGCAACGCAA GCCTCTGGGA ACTGTGGCAC CCGAAAATCC 900

AACCTTCTGT TGAATTTTCA GGGCGGATTT GTGAATCTCA CATTTACCAA GGATGAAGAA 960

TCATATTATA TCAGTGAAGT GGGAGCCTAT TTGACCGTCT CAGATCCAGA GACAGTTTAC 1020

CAAGGAATCA AACATGCGGT GGTGATGTTC CAGACAGCAG TCGGGCATTC CTTCAAGTGC 1080

GTGAGTGAAC AGAGCCTCCA GTTGTCAGCC CACCTGCAGG TGAAAACAAC CGATGTCCAA 1140

CTTCAAGCCT TTGATTTTGA AGATGACCAC TTTGGAAATG TGGATGAGTG CTCGTCTGAC 1200

TACACAATTG TGCTTCCTGT GATTGGGGCC ATCGTGGTTG GTGTCTGCCT TATGGGTATG 1260

GGTGTCTATA AAATCCGCCT AAGGTGTCAA TCATCTGGAT ACCAGAGAAT CTAATTGTTG 1320

CCCGGGGGGA ATGAAAATAA TGGAATTTAG AGAACTCTTT CATCCCTTCC AGGATGGATG 1380

TTGGGAAATT CCCTCAGAGT GTGGGTCCTT CAAACAATGT AAACCACCAT CTTCTATTCA 1440

AATGAAGTGA GTCATGTGTG ATTTAAGTTC AGGCAGCACA TCAATTTCTA AATACTTTTT 1500

GTTTATTTTA TGAAAGATAT AGTGAGCTGT TTATTTTCTA GTTTCCTTTA GAATATTTTA 1560

GCCACTCAAA GTCAACATTT GAGATATGTT GAATTAACAT AATATATGTA AAGTAGAATA 1620

AGCCTTCAAA TTATAAACCA AGGGTCAATT GTAACTAATA CTACTGTGTG TGCATTGAAG 1680

ATTTTATTTT ACCCTTGATC TTAACAAAGC CTTTGCTTTG TTATCAAATG GACTTTCAGT 1740

GCTTTTACTA TCTGTGTTTT ATGGTTTCAT GTAACATACA TATTCCTGGT GTAGCACTTA 1800

ACTCCTTTTC CACTTTAAAT TTGTTTTTGT TTTTTGAGAC GGAGTTTCAC TCTTGTCACC 1860

CAGGCTGGAG TACAGTGGCA CGATCTCGGC TTATGGCAAC CTCCGCCTCC CGGGTTCAAG 1920

TGATTCTCCT GCTTCAGCTT CCCGAGTAGC TGGGATTACA GGCACACACT ACCACGCCTG 1980

GCTAATTTTT GTATTTTTAT TATAGACGGG TTTCACCATG TTGGCCAGAC TGGTCTTGAA 2040

CTCTTGACCT CAGGTGATCC ACCCACCTCA GCCTCCCAAA GTGCTGGGAT TACAGGCATG 2100

AGCCATTGCG CCCGGCCTTA AATGTTTTTT TTAATCATCA AAAAGAACAA CATATCTCAG 2160 GTTGTCTAAG TGTTTTTATG TAAAACCAAC AAAAAGAACA AATCAGCTTA TATTTTTTAT 2220

CTTGATGACT CCTGCTCCAG AATTGCTAGA CTAAGAATTA GGTGGCTACA GATGGTAGAA 2280

CTAAACAATA AGCAAGAGAC AATAATAATG GCCCTTAATT ATTAACAAAG TGCCAGAGTC 2340

TAGGCTAAGC ACTTTATCTA TATCTCATTT CATTCTCACA ACTTATAAGT GAATGAGTAA 2400

ACTGAGACTT AAGGGAACTG AATCACTTAA ATGTCACCTG GCTAACTGAT GGCAGAGCCA 2460

GAGCTTGAAT TCATGTTGGT CTGACATCAA GGTCTTTGGT CTTCTCCCTA CACCAAGTTA 2520

CCTACAAGAA CAATGACACC ACACTCTGCC TGAAGGCTCA CACCTCATAC CAGCATACGC 2580

TCACCTTACA GGGAAATGGG TTTATCCAGG ATCATGAGAC ATTAGGGTAG ATGAAAGGAG 2640

AGCTTTGCAG ATAACAAAAT AGCCTATCCT TAATAAATCC TCCACTCTCT GGAAGGAGAC 2700

TGAGGGGCTT TGTAAAACAT TAGTCAGTTG CTCATTTTTA TGGGATTGCT TAGCTGGGCT 2760

GTAAAGATGA AGGCATCAAA TAAACTCAAA GTATTTTTAA ATTTTTTTGA TAATAGAGAA 2820

ACTTCGCTAA CCAACTGTTC TTTCTTGAGT GTATAGCCCC ATCTTGTGGT AACTTGCTGC 2880

TTCTGCACTT CATATCCATA TTTCCTATTG TTCACTTTAT TCTGTAGAGC AGCCTGCCAA 2940

GAATTTTATT TCTGCTGTTT TTTTTGCTGC TAAAGAAAGG AACTAAGTCA GGATGTTAAC 3000

AGAAAAGTCC ACATAACCCT AGAATTCTTA GTCAAGGAAT AATTCAAGTC AGCCTAGAGA 3060

CCATGTTGAC TTTCCTCATG TGTTTCCTTA TGACTCAGTA AGTTGGCAAG GTCCTGACTT 3120 TAGTCTTAAT AAAACATTGA ATTGTAGTAA AGGTTTTTGC AATAAAAACT TACTTTGG

Seq ID NO: 489 Protein sequence Protein Accession ft: NP 055213.1

1 11 21 31 41 51

I I I I I I

MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK PVQQPAKQAP 60

HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI TYTLVTTQAT PNNSHTAPPV 120

TEVTVGPSLA PYSLPPTITP PAHTAGTSSS TVSHTTGNTT QPSNQTTLPA TLSIALHKST 180

TGQKPDQPTH APGTTAAAHN TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA 240

EMGIQLIVQD KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES 300

YYISEVGAYL TVSDPETVYQ GIKHAWMFQ TAVGHSFKCV SEQSLQLSAH LQVKTTDVQL 360 QAFDFEDDHF GNVDECSSDY TIVLPVIGAI WGLCLMGMG VYKIRLRCQS SGYQRI

Seq ID NO: 490 DNA sequence

Nucleic Acid Accession ft: NM_005409.3

Coding sequence: 94.-378

1 11 21 31 41 51

1 I I 1 I I

TTCCTTTCAT GTTCAGCATT TCTACTCCTT CCAAGAAGAG CAGCAAAGCT GAAGTAGCAG 60

CAACAGCACC AGCAGCAACA GCAAAAAACA AACATGAGTG TGAAGGGCAT GGCTATAGCC 120

TTGGCTGTGA TATTGTGTGC TACAGTTGTT CAAGGCTTCC CCATGTTCAA AAGAGGACGC 180

TGTCTTTGCA TAGGCCCTGG GGTAAAAGCA GTGAAAGTGG CAGATATTGA GAAAGCCTCC 240

ATAATGTACC CAAGTAACAA CTGTGACAAA ATAGAAGTGA TTATTACCCT GAAAGAAAAT 300

AAAGGACAAC GATGCCTAAA TCCCAAATCG AAGCAAGCAA GGCTTATAAT CAAAAAAGTT 360

GAAAGAAAGA ATTTTTAAAA ATATCAAAAC ATATGAAGTC CTGGAAAAGG GCATCTGAAA 420

AACCTAGAAC AAGTTTAACT GTGACTACTG AAATGACAAG AATTCTACAG TAGGAAACTG 480

AGACTTTTCT ATGGTTTTGT GACTTTCAAC TTTTGTACAG TTATGTGAAG GATGAAAGGT 540

GGGTGAAAGG ACCAAAAACA GAAATACAGT CTTCCTGAAT GAATGACAAT CAGAATTCCA 600

CTGCCCAAAG GAGTCCAGCA ATTAAATGGA TTTCTAGGAA AAGCTACCTT AAGAAAGGCT 660

GGTTACCATC GGAGTTTACA AAGTGCTTTC ACGTTCTTAC TTGTTGTATT ATACATTCAT 720

GCATTTCTAG GCTAGAGAAC CTTCTAGATT TGATGCTTAC AACTATTCTG TTGTGACTAT 780

GAGAACATTT CTGTCTCTAG AAGTTATCTG TCTGTATTGA TCTTTATGCT ATATTACTAT 840

CTGTGGTTAC AGTGGAGACA TTGACATTAT TACTGGAGTC AAGCCCTTAT AAGTCAAAAG 900

CATCTATGTG TCGTAAAGCA TTCCTCAAAC ATTTTTTCAT GCAAATACAC ACTTCTTTCC 960

CCAAATATCA TGTAGCACAT CAATATGTAG GGAAACATTC TTATGCATCA TTTGGTTTGT 1020

TTTATAACCA ATTCATTAAA TGTAATTCAT AAAATGTACT ATGAAAAAAA TTATACGCTA 1080

TGGGATACTG GCAACAGTGC ACATATTTCA TAACCAAATT AGCAGCACCG GTCTTAATTT 1140

GATGTTTTTC AACTTTTATT CATTGAGATG TTTTGAAGCA ATTAGGATAT GTGTGTTTAC 1200

TGTACTTTTT GTTTTGATCC GTTTGTATAA ATGATAGCAA TATCTTGGAC ACATTTGAAA 1260

TACAAAATGT TTTTGTCTAC CAAAGAAAAA TGTTGAAAAA TAAGCAAATG TATACCTAGC 1320

AATCACTTTT ACTTTTTGTA ATTCTGTCTC TTAGAAAAAT ACATAATCTA ATCAATTTCT 1380

TTGTTCATGC CTATATACTG TAAAATTTAG GTATACTCAA GACTAGTTTA AAGAATCAAA 1440 GTCATTTTTT TCTCTAATAA ACTACCACAA CCTTTCTTTT TTAAAAAAAA AAA

Seq ID NO: 491 Protein sequence Protein Accession ft: NP_005400.1

1 11 21 31 41 51

I I I I I I

MSVKGMAIAL AVILCATWQ GFPMFKRGRC LCIGPGVKAV KVADIEKASI MYPSNNCDKI 60 EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF

Seq ID NO: 492 DNA sequence

Nucleic Acid Accession ft: NM_000577.1

Coding sequence: 41..520

1 11 21 31 41 51

G IGCACGAGGG GIAAGACCTCC TIGTCCTATCA GIGCCCTCCCC AITGGCTTTAG AIGACGATCTG 60

CCGACCCTCT GGGAGAAAAT CCAGCAAGAT GCAAGCCTTC AGAATCTGGG ATGTTAACCA 120

GAAGACCTTC TATCTGAGGA ACAACCAACT AGTTGCCGGA TACTTGCAAG GACCAAATGT 180

CAATTTAGAA GAAAAGATAG ATGTGGTACC CATTGAGCCT CATGCTCTGT TCTTGGGAAT .240

CCATGGAGGG AAGATGTGCC TGTCCTGTGT CAAGTCTGGT GATGAGACCA GACTCCAGCT 300

GGAGGCAGTT AACATCACTG ACCTGAGCGA GAACAGAAAG CAGGACAAGC GCTTCGCCTT 360

CATCCGCTCA GACAGTGGCC CCACCACCAG TTTTGAGTCT GCCGCCTGCC CCGGTTGGTT 420

CCTCTGCACA GCGATGGAAG CTGACCAGCC CGTCAGCCTC ACCAATATGC CTGACGAAGG 480

CGTCATGGTC ACCAAATTCT ACTTCCAGGA GGACGAGTAG TACTGCCCAG GCCTGCCTGT 540

TCCCATTCTT GCATGGCAAG GACTGCAGGG ACTGCCAGTC CCCCTGCCCC AGGGCTCCCG 600 GCTATGGGGG CACTGAGGAC CAGCCATTGA GGGGTGGACC CTCAGAAGGC GTCACAACAA 660

CCTCGTCACA GGACTCTGCC TCCTCTTCAA CTGACCAGCC TCCATGCTGC CTCCAGAATG 720

GTCTTTCTAA TGTGTGAATC AGAGCACAGC AGCCCCTGCA CAAAGCCCTT CCATGTCGCC 780

TCTGCATTCA GGATCAAACC CCGACCACCT GCCCAACCTG CTCTCCTCTT GCCACTGCCT 840

CTTCCTCCCT CATTCCACCT TCCCATGCCC TGGATCCATC AGGCCACTTG ATGACCCCCA 900

ACCAAGTGGC TCCCACACCC TGTTTTACAA AAAAGAAAAG ACCAGTCCAT GAGGGAGGTT 960

TTTAAGGGTT TGTGGAAAAT GAAAATTAGG ATTTCATGAT TTTTTTTTTT CAGTCCCCGT 1020

GAAGGAGAGC CCTTCATTTG GAGATTATGT TCTTTCGGGG AGAGGCTGAG GACTTAAAAT 1080

ATTCCTGCAT TTGTGAAATG ATGGTGAAAG TAAGTGGTAG CTTTTCCCTT CTTTTTCTTC 1140

10 TTTTTTTGTG ATGTCCCAAC TTGTAAAAAT TAAAAGTTAT GGTACTATGT TAGCCCCATA 1200

ATTTTTTTTT TCCTTTTAAA ACACTTCCAT AATCTGGACT CCTCTGTCCA GGCACTGCTG 1260

CCCAGCCTCC AAGCTCCATC TCCACTCCAG ATTTTTTACA GCTGCCTGCA GTACTTTACC 1320

TCCTATCAGA AGTTTCTCAG CTCCCAAGGC TCTGAGCAAA TGTGGCTCCT GGGGGTTCTT 1380

TCTTCCTCTG CTGAAGGAAT AAATTGCTCC TTGACATTGT AGAGCTTCTG GCACTTGGAG 1440

15 ACTTGTATGA AAGATGGCTG TGCCTCTGCC TGTCTCCCCC ACCAGGCTGG GAGCTCTGCA 1500

GAGCAGGAAA CATGACTCGT ATATGTCTCA GGTCCCTGCA GGGCCAAGCA CCTAGCCTCG 1560

CTCTTGGCAG GTACTCAGCG AATGAATGCT GTATATGTTG GGTGCAAAGT TCCCTACTTC 1620

CTGTGACTTC AGCTCTGTTT TACAATAAAA TGTTGAAAAT GCCTAAAAAA AAAAAAAAAA 1680 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAA

20

Seq ID NO: 493 Protein sequence Protein Accession ft: NP 000568.1

1 11 21 31 41 51

25 i i i i i i

MALETICRPS GRKSSKMQAF RIWDVNQKTF YLRNNQLVAG YLQGPNVNLE EKIDWPIEP 60

HALFLGIHGG KMCLSCVKSG DETRLQLEAV NITDLSENRK QDKRFAFIRS DSGPTTSFES 120 AACPGWFLCT AMEADQPVSL TNMPDEGVMV TKFYFQEDE

30 Seq ID NO: 494 DNA sequence

Nucleic Acid Accession ft: NM_002081.1 Coding sequence: 222..1898

__ 1 11 21 31 41 51

35 i i i i i i

GGCTGCCCGA GCGAGCGTTC GGACCTCGCA CCCCGCGCGC CCCGCGCCGC CGCCGCCGCC 60

GGCTTTTGTT GTCTCCGCCT CCTCGGCCGC CGCCGCCTCT GGACCGCGAG CCGCGCGCGC 120

CGGGACCTTG GCTCTGCCCT TCGCGGGCGG GAACTGCGCA GGACCCGGCC AGGATCCGAG 180

AGAGGCGCGG GCGGGTGGCC GGGGGCGCCG CCGGCCCCGC CATGGAGCTC CGGGCCCGAG 240 0 GCTGGTGGCT GCTATGTGCG GCCGCAGCGC TGGTCGCCTG CGCCCGCGGG GACCCGGCCA 300

GCAAGAGCCG GAGCTGCGGC GAGGTCCGCC AGATCTACGG AGCCAAGGGC TTCAGCCTGA 360

GCGACGTGCC CCAGGCGGAG ATCTCGGGTG AGCACCTGCG GATCTGTCCC CAGGGCTACA 420

CCTGCTGCAC CAGCGAGATG GAGGAGAACC TGGCCAACCG CAGCCATGCC GAGGTGGAGA 480

CCGCGCTCCG GGACAGCAGC CGCGTCCTGC AGGCCATGCT TGCCACCCAG CTGCGCAGCT 540 5 TCGATGACCA CTTCCAGCAC CTGCTGAACG ACTCGGAGCG GACGCTGCAG GCCACCTTCC 600

CCGGCGCCTT CGGAGAGCTG TACACGCAGA ACGCGAGGGC CTTCCGGGAC CTGTACTCAG 660

AGCTGCGCCT GTACTACCGC GGTGCCAACC TGCACCTGGA GGAGACGCTG GCCGAGTTCT 720

GGGCCCGCCT GCTCGAGCGC CTCTTCAAGC AGCTGCACCC CCAGCTGCTG CTGCCTGATG 780

ACTACCTGGA CTGCCTGGGC AAGCAGGCCG AGGCGCTGCG GCCCTTCGGG GAGGCCCCGA 840 0 GAGAGCTGCG CCTGCGGGCC ACCCGTGCCT TCGTGGCTGC TCGCTCCTTT GTGCAGGGCC 900

TGGGCGTGGC CAGCGACGTG GTCCGGAAAG TGGCTCAGGT CCCCCTGGGC CCGGAGTGCT 960

CGAGAGCTGT CATGAAGCTG GTCTACTGTG CTCACTGCCT GGGAGTCCCC GGCGCCAGGC 1020

CCTGCCCTGA CTATTGCCGA AATGTGCTCA AGGGCTGCCT TGCCAACCAG GCCGACCTGG 1080

ACGCCGAGTG GAGGAACCTC CTGGACTCCA TGGTGCTCAT CACCGACAAG TTCTGGGGTA 1140 5 CATCGGGTGT GGAGAGTGTC ATCGGCAGCG TGCACACGTG GCTGGCGGAG GCCATCAACG 1200

CCCTCCAGGA CAACAGGGAC ACGCTCACGG CCAAGGTCAT CCAGGGCTGC GGGAACCCCA 1260

AGGTCAACCC CCAGGGCCCT GGGCCTGAGG AGAAGCGGCG CCGGGGCAAG CTGGCCCCGC 1320

GGGAGAGGCC ACCTTCAGGC ACGCTGGAGA AGCTGGTCTC TGAAGCCAAG GCCCAGCTCC 1380

GCGACGTCCA GGACTTCTGG ATCAGCCTCC CAGGGACACT GTGCAGTGAG AAGATGGCCC 1440 0 TGAGCACTGC CAGTGATGAC CGCTGCTGGA ACGGGATGGC CAGAGGCCGG TACCTCCCCG 1500

AGGTCATGGG TGACGGCCTG GCCAACCAGA TCAACAACCC CGAGGTGGAG GTGGACATCA 1560

CCAAGCCGGA CATGACCATC CGGCAGCAGA TCATGCAGCT GAAGATCATG ACCAACCGGC 1620

TGCGCAGCGC CTACAACGGC AACGACGTGG ACTTCCAGGA CGCCAGTGAC GACGGCAGCG 1680

GCTCGGGCAG CGGTGATGGC TGTCTGGATG ACCTCTGCGG CCGGAAGGTC AGCAGGAAGA 1740 5 GCTCCAGCTC CCGGACGCCC TTGACCCATG CCCTCCCAGG CCTGTCAGAG CAGGAAGGAC 1800

AGAAGACCTC GGCTGCCAGC TGCCCCCAGC CCCCGACCTT CCTCCTGCCC CTCCTCCTCT 1860

TCCTGGCCCT TACAGTAGCC AGGCCCCGGT GGCGGTAACT GCCCCAAGGC CCCAGGGACA 1920

GAGGCCAAGG ACTGACTTTG CCAAAAATAC AACACAGACG ATATTTAATT CACCTCAGCC 1980

TGGAGAGGCC TGGGGTGGGA CAGGGAGGGC CGGCGGCTCT GAGCAGGGGC AGGCGCAGAG 2040 0 GTCCCAGCCC GAGGCCTGGC CTCGCCTGCC TTTCTGCCTT TTAATTTTGT ATGAGGTCCT 2100

CAGGTCAGCT GGGAGCCAGT GTGCCCAAAA GCCATGTATT TCAGGGACCT CAGGGGCACC 2160

TCCGGCTGCC TAGCCCTCCC CCCAGCTCCC TGCACCGCCG CAGAAGCAGC CCCTCGAGGC 2220

CTACAGAGGA GGCCTCAAAG CAACCCGCTG GAGCCCACAG CGAGCCTGTG CCTTCCTCCC 2280

CGCCTCCTCC CACTGGGACT CCCAGCAGAG CCCACCAGCC AGCCCTGGCC CACCCCCCAG 2340 5 CCTCCAGAGA AGCCCCGCAC GGGCTGTCTG GGTGTCCGCC ATCCAGGGTC TGGCAGAGCC 2400

TCTGAGATGA TGCATGATGC CCTCCCCTCA GCGCAGGCTG CAGAGCCCGG CCCCACCTCC 2460

CTGCGCCCTT GAGGGGCCCC AGCGTCTGCA GGGTGACGCC TGAGACAGCA CCACTGCTGA 2520

GGAGTCTGAG GACTGTCCTC CCACAGACCC TGCAGTGAGG GGCCCTCCAT GCGCAGATGA 2580

GGGGCCACTG ACCCACCTGC GCTTCTGCTG GAGGAGGGGA AGCTGGGCCC AAAGGCCCAG 2640 0 GGAGGCAGCG TGGGCTCTGC CAATGTGGGC TGCCCCTCGC ACACAGGGCT CACAGGGCAG 2700

GCCTTGCTGG GGTCCAGGGC TGTTGGAGGA CCCCGAGGGC TGAGGAGGAG CCAGGACCCG 2750

CCTGCTCCCA TCCTCACCCA GATCAGGAAC CAGGGCCTCC CTGTTCACGG TGACACAGGT 2820

CAGGGCTCAG AGTGACCCTC GGCTGTCACC TGCTCACAGG GATGCTGGTG GCTGGTGAGA 2880

CCCCGCACTG CACACGGGAA TGCCTAGGTC CCTTCCCGAC CCAGCCAGCT GCACTGCAGG 2940 5 GCACGGGGAC CTGGATAGTT AAGGGCTTTT CCAAACATGC ATCCATTTAC TGACACTTCC 3000

TGTCCTTGTT CATGGAGAGC TGTTCGCTCC TCCCAGATGG CTTCGGAGGC CCGCAGGGCC 3060

CACCTTGGAC CCTGGTGACC TCCTGTCACT CACTGAGGCC ATCAGGGCCC TGCCCCAGGC 3120 CTGGACGGGC CCTCCTTCCC TCCTGTGCCC CAGCTGCCAG GTGGCCCTGG GGAGGGGTGG 3180

TGTGGTGTTG GGAAGGGGTC CTGCAGGGGG AGGAGGACTT GGAGGGTCTG GGGGCAGCTG 3240

TCCTGAACCG ACTGACCCTG AGGAGGCCGC TTAGTGCTGC TTTGCTTTTC ATGACCGTCC 3300

CGCACAGTGG ACGGAGGTCC CCGGTTGCTG GTCAGGTCCC CATGGCTTGT TCTCTGGAAC 3360

CTGACTTTAG ATGTTTTGGG ATCAGGAGCC CCCAACACAG GCAAGTCCAC CCCATAATAA 3420

CCCTGCCAGT GCCAGGGTGG GCTGGGGACT CTGGCACAGT GATGCCGGGC GCCAGGACAG 3480

CAGCACTCCC GCTGCACACA GACGGCCTAG GGGTGGCGCT CAGACCCCAC CCTACGCTCA 3540

TCTCTGGAAG GGGCAGCCCT GAGTGGTCAC TGGTCAGGGC AGTGGCCAAG CCTGCTGTGT 3600

CCTTCCTCCA CAAGGTCCCC CCACCGCTCA GTGTCAGCGG GTGACGTGTG TTCTTTTGAG 3660 TCCTTGTATG AATAAAAGGC TGGAAACCTA AA

Seq ID NO: 495 Protein sequence Protein Accession ft: NP_002072.1

1 11 21 31 41 51

I I I I I I

MELRARGWWL LCAAAALVAC ARGDPASKSR SCGEVRQIYG AKGFSLSDVP QAEISGEHLR 60

ICPQGYTCCT SEMEENLANR SHAELETALR DSSRVLQAML ATQLRSFDDH FQHLLNDSER 120

TLQATFPGAF GELYTQNARA FRDLYSELRL YYRGANLHLE ETLAEFWARL LERLFKQLHP 180

QLLLPDDYLD CLGKQAEALR PFGEAPRELR LRATRAFVAA RSFVQGLGVA SD RKVAQV 240

PLGPECSRAV MKLVYCAHCL GVPGARPCPD YCRNVLKGCL ANQADLDAEW RNLLDSMVLI 300

TDKFWGTSGV ESVIGSVHTW LAEAINALQD NRDTLTAKVI QGCGNPKVNP QGPGPEEKRR 360

RGKLAPRERP PSGTLEKLVS EAKAQLRDVQ DFWISLPGTL CSEKMALSTA SDDRCWNGMA 420

RGRYLPEVMG DGLANQINNP EVEVDITKPD MTIRQQIMQL KIMTNRLRSA YNGNDVDFQD 480 ASDDGSGSGS

Seq ID NO: 496 DNA sequence

Nucleic Acid Accession ft: NM_001650.2

Coding sequence: 40.1011

1 11 21 31 41 51

I 1 I I I I

GGGGCAGGCA ATGAGAGCTG CACTCTGGCT GGGGAAGGCA TGAGTGACAG ACCCACAGCA 60

AGGCGGTGGG GTAAGTGTGG ACCTTTGTGT ACCAGAGAGA ACATCATGGT GGCTTTCAAA 120

GGGGTCTGGA CTCAAGCTTT CTGGAAAGCA GTCACAGCGG AATTTCTGGC CATGCTTATT 180

TTTGTTCTCC TCAGCCTGGG ATCCACCATC AACTGGGGTG GAACAGAAAA GCCTTTACCG 240

GTCGACATGG TTCTCATCTC CCTTTGCTTT GGACTCAGCA TTGCAACCAT GGTGCAGTGC 300

TTTGGCCATA TCAGCGGTGG CCACATCAAC CCTGCAGTGA CTGTGGCCAT GGTGTGCACC 360

AGGAAGATCA GCATCGCCAA GTCTGTCTTC TACATCGCAG CCCAGTGCCT GGGGGCCATC 420

ATTGGAGCAG GAATCCTCTA TCTGGTCACA CCTCCCAGTG TGGTGGGAGG CCTGGGAGTC 480

ACCATGGTTC ATGGAAATCT TACCGCTGGT CATGGTCTCC TGGTTGAGTT GATAATCACA 540

TTTCAATTGG TGTTTACTAT CTTTGCCAGC TGTGATTCCA AACGGACTGA TGTCACTGGC 600

TCAATAGCTT TAGCAATTGG ATTTTCTGTT GCAATTGGAC ATTTATTTGC AATCAATTAT 660

ACTGGTGCCA GCATGAATCC CGCCCGATCC TTTGGACCTG CAGTTATCAT GGGAAATTGG 720

GAAAACCATT GGATATATTG GGTTGGGCCC ATCATAGGAG CTGTCCTCGC TGGTGGCCTT 780

TATGAGTATG TCTTCTGTCC AGATGTTGAA TTCAAACGTC GTTTTAAAGA AGCCTTCAGC 840

AAAGCTGCCC AGCAAACAAA AGGAAGCTAC ATGGAGGTGG AGGACAACAG GAGTCAGGTA 900

GAGACGGATG ACCTGATTCT AAAACCTGGA GTGGTGCATG TGATTGACGT TGACCGGGGA 960

GAGGAGAAGA AGGGGAAAGA CCAATCTGGA GAGGTATTGT CTTCAGTATG ACTAGAAGAT 1020

CGCACTGAAA GCAGACAAGA CTCCTTAGAA CTGTCCTCAG ATTTCCTTCC ACCCATTAAG 1080

GAAACAGATT TGTTATAAAT TAGAAATGTG CAGGTTTGTT GTTTCATGTC ATATTACTCA 1140

GTCTAAACAA TAAATATTTC ATAATTTACA AAGGAGGAAC GGAAGAAACC TATTGTGAAT 1200

TCCAAATCTA AAAAAAGAAA TATTTTTAAG ATGTTCTTAA GCAAATATAT ACCTATTTTA 1260

TCTAGTTACC TTTCATTAAC AACCAATTTT AACCGTGTGT CAAGATTTGG TTAAGTCTTG 1320

CCTGACAGAA CTCAAAGACA CGTCTATCAG CTTATTCCTT CTCTACTGGA ATATTGGTAT 1380 AGTCAATTCT TATTTGAATA TTTATTCTAT TAAACTGAGT TTAACAATGG C

Seq ID NO: 497 Protein sequence Protein Accession ft: NP_001641.1

1 11 21 31 41 51

I I I I I I

MSDRPTARRW GKCGPLCTRE NIMVAFKGVW TQAFWKAVTA EFLAMLIFVL LSLGSTINWG 60

GTEKPLPVDM VLISLCFGLS IATMVQCFGH ISGGHINPAV TVAMVCTRKI SIAKSVFYIA 120

AQCLGAIIGA GILYLVTPPS WGGLGVTMV HGNLTAGHGL LVELIITFQL VFTIFASCDS 180

KRTDVTGSIA LAIGFSVAIG HLFAINYTGA SMNPARSFGP AVIMGNWENH WIYWVGPIIG 240

AVLAGGLYEY VFCPDVEFKR RFKEAFSKAA QQTKGSYMEV EDNRSQVETD DLILKPGWH 300 VIDVDRGEEK KGKDQSGEVL SSV Seq ID NO: 498 DNA sequence

Nucleic Acid Accession ft: AB020684.1 Coding sequence : 1..1744 1 11 21 31 41 51 i i i i i i

CCCCCTTGTC ATTAATACAT TAAAAAGATT CAATCTTTAC CCTGAGGTAA TTTTGGCCAG 60

TTGGTACCGG ATTTATACCA AAATAATGGA CTTGATTGGT ATTCAAACCA AGATATGTTG 120

GACGGTTACC AGAGGAGAAG GACTCAGTCC TATTGAAAGC TGTGAAGGAT TGGGAGATCC 180

TGCTTGCTTT TATGTTGCTG TAATTTTTAT TTTAAATGGA CTAATGATGG CATTATTCTT 240

CATATATGGC ACATATTTAA GTGGCAGCCG ATTAGGAGGC CTGGTTACAG TGTTGTGCTT 300

CTTTTTCAAT CATGGAGAGT GTACCCGTGT AATGTGGACA CCACCTCTCC GTGAAAGCTT 360

CTCATATCCA TTTCTTGTTC TTCAGATGTT GCTAGTGACT CATATTCTCA GGGCTACAAA 420

ACTTTATAGA GGAAGCTTGA TTGCACTCTG CATTTCCAAT GTATTTTTCA TGCTTCCTTG 480

GCAGTTTGCT CAGTTTGTAC TTCTTACTCA GATTGCATCA TTATTTGCAG TATATGTTGT 540

CGGGTACATT GATATATGTA AATTACGGAA GATCATTTAT ATACACATGA TTTCTCTTGC 600

ACTTTGTTTT GTTTTGATGT TTGGGAACTC AATGTTATTA ACTTCTTATT ATGCTTCTTC 660

TTTGGTAATT ATTTGGGGTA TTCTGGCAAT GAAACCACAT TTCCTGAAAA TAAATGTATC 720 TGAACTTAGT TTATGGGTTA TTCAAGGATG TTTTTGGTTA TTTGGAACTG TCATACTTAA 780

ATACTTGACA TCTAAAATTT TTGGTATTGC AGATGACGCT CATATTGGCA ACTTACTAAC 840

ATCAAAATTC TTTAGTTATA AGGATTTTGA TACTTTATTG TATACCTGTG CAGCGGAGTT 900

TGACTTTATG GAAAAAGAGA CTCCACTGAG ATACACAAAG ACATTATTGC TTCCAGTTGT 960

TCTTGTAGTG TTTGTTGCTA TTGTTAGAAA GATTATTAGT GATATGTGGG GTGTCTTAGC 1020

TAAACAACAG ACACATGTAA GAAAACACCA GTTTGATCAT GGAGAGCTGG TTTACCATGC 1080

ATTGCAATTG TTAGCATATA CAGCCCTTGG TATTTTAATT ATGAGACTAA AACTCTTCTT 1140

GACACCACAC ATGTGTGTTA TGGCATCACT GATCTGCTCA AGACAGCTAT TTGGATGGCT 1200

CTTTTGCAAA GTACATCCTG GTGCTATTGT GTTTGCTATA TTAGCAGCAA TGTCAATACA 1260

AGGTTCAGCA AATCTGCAAA CCCAGTGGAA TATTGTAGGG GAGTTCAGCA ATTTGCCCCA 1320

AGAAGAACTT ATAGAATGGA TCAAATATAG TACTAAACCA GATGCAGTGT TTGCGGGTGC 1380

CATGCCCACG ATGGCAAGTG TTAAGCTCTC TGCACTTCGG CCCATTGTGA ATCATCCACA 1440

TTATGAAGAC GCAGGCTTGA GAGCCAGAAC AAAAATAGTA TACTCAATGT ATAGTCGGAA 1500

AGCAGCCGAA GAAGTGAAGC GAGAACTGAT AAAGTTAAAA GTGAACTATT ACATTCTAGA 1560

AGAGTCATGG TGTGTAAGAA GATCCAAGCC TGGTTGCAGT ATGCCTGAAA TTTGGGATGT 1620

AGAAGATCCT GCCAATGCTG GGAAAACTCC CTTATGTAAC CTCTTGGTGA AGGATTCCAA 1680

ACCTCACTTC ACCACTGTAT TCCAGAACAG TGTTTACAAA GTCCTAGAAG TTGTAAAAGA 1740

ATGACTGCTA CATGACCTGC TGCCTACGGA GAACTACATC TGTAATGGTT TTAATGTTTT 1800

GCTAAGTCAT GTGTTGTTCA TATCCCAAAA ACTTTTATAG GTAACTGTTT TCAAATAGAA 1860

AACGTTTTAT TTGGTCAATT TGAATGTCAT TCTAATTATA AAAATGACTT ACACCTTTAT 1920

CAATTGGTTA CTATTTCAAT GCACCCTTTA AAATTTGCTA TGCAAATGAG TATATGCTTG 1980

TACTTGACTT TAATATTTGT GCTAAAGTGA GCAAAGCTAC CTGTATAAAG AAAACACAGT 2040

GGGTTGTGAC AAGGATGACA TGAAAATACA GGACAATTCT GACAATGTAG GGGCTGATTT 2100

TATAGTGTAA GAACTATTAA TGCCCCTTGC TTCTTTTTTC TGCCTCTTGC TCTTGTCTTT 2160 TGGACATTTC AGTGATTGTA AGTTCTTCGG TCATGTCAGC CCCTGTCATC AACTTGAGTT 2220

ACAGTAGATG GGGCAGACAT GGAGTGTTTG CTATATAAAA CTATCTGTTT GTTTTACTTC 2280

CTTGTGCGCT TTTTGTTCTC TGTTCTCTTG TTAATGAAGC TTTTCCTGCC CATTATTAAT 2340

CCAAACTCTT GGACCTTGTG GTTAGGAAAT TCCCTTAACT TCCAGCCATA TGGCATTATC 2400

GTGTCTCTTT CTCTCTCTCT CTTGCTCTCT CTCTTCTCCT CTTCCCCATA TTTTCTGTCA 2460 AATAAGTACT GTTTACTCAT TTAGTTGCTT ATCAAGTACT TATTCTTGGT TTTAAAAAAA 2520

ATTAATGGTA ACTGTATTTT TCTCATTTTT AGCATTATTC AAATGTTTAT ATTTTAATAC 2580

CTTTAAACCA CTTTAAAGTT TTTTCATGTT TAATTATAGT TTTAAGAAAA ACTATTTTGA 2640

ACAACCCCAA ATATAGTGCA TCTAGAAACT AATGTATATT TGATTAGACA TCATTTATAG 2700

TGGAACAGTA GACTGTAGTA CATGGTAATT TTTCTTTTAC TATTAAGATA CAATAAAACA 2760 TGACTAATTT TGCTGTCAAA AATGTAAAGA ATAATGATAA ATGGAGTTTT TTATATTTTA 2820

CTTTTAAGAT TGCCTGTCTT TAATAAGACA AAGCCTTAAG CCTTATGTTA TAATTTTGGT 2880

TCTAAAAACC ATCATTTCAG TATAAGGAAT AAGTATATTT CGTCCTCCTC TTTAGTTTTT 2940

TTCTTCCTAT TTATTTTTAT TTTGAAAAAT TTCTACACCT TCTTTGAATT CCTTGTATGA 3000

ATTTTTGTTT CTTAGAAGTT AATTTGTGTG AAATGAGATT CTTCAAAACG ATGAAACCTC 3060

ATAGCTCTGA GAAAAGGTTT TAGGGTTTTA AATTCTAAGC AAAGCGTGAC TATGGCTGAC 3120

AGACTACACA TTTAATTATA CAGCTTCTCT TTCTTAACCA CAGGCAGATT AACCTCATTG 3180

TGGATTGTCC TTCAGACCTT AGTCCTCAGG CATGGTTTCT GGTGCCCACT CCTGGAAGCC 3240

GCTGTTCCCT TTCTACCTTC TTACCAGAGC CCAAGGGCAG GCCTGGTCCC GGGGAAGCAG 3300

CAGCTTGCTG ACATAAGTCA GCTGCAAAGG CTGAGGAGTG TGCCCTCAGA GAAGCACCGC 3360

CCCCCAGTCT TGTGCCAGCG CCTAGAGCCG CAGCTCCCAG GGATGCTCCT TCCCTGGAGG 3420

" CAGCCCAGGA GAGGGACTCT GGCAGCGTTC TTCAGATTTG TGGCCACTGT TTCTCATTTG 3480

CTGGTTGACT GTTTTTATTT CTTAGGCTTT TGCTAGTTTT AGAAAATAGG GAAGCAGCCC 3540

TTGATTTGTG GATTAAAAGC AACATTTGAG CGATGATGCA CAACAGTCCA GGAAAATGGG 3600

CGGTGGACAC TTGAGGCTGA GGATGGGAGT TGACATGAGC AGGGAGAGGG AGGTGCGCGC 3660

TGCTTATCTG TGATTGTTGC TCACCTGAGT GTGGCTGATT GTGTACATCC AGCAGTTACA 3720

ATTTTTAAAA ATTATACTTT TACATTTATT TTATATTTTT CTCACCCCCA GTAATTTCCT 3780

TCCAAAGAAG TTCACATGTA ATAAGTAGAA ATTCTGTATA GGAAAAAAGC ATTAAAAATA 3840

CTATTATAAC TGCTTCATTT GCTGGGAACC ATTAAAAGTA ATATAAATTA GCTTTTTCCA 3900

GAAGGAΓCCΓ TTTGTAGCAG ΓGTTTATGAA TGTAACCCCC AGCAAAATAT GGCTATATAT 3960

TAGGGGAGCC AGTTTGGAGC AGAGGCCTGA AGGTCCCTGC TATGCAGCCG TGGCCACAGC 4020

TCGCAGCCCA AGCACTGTGG AGCATCCACA CCTTTGATGG CAATGCAGAT TGGTAGCAGG 4080

TTCCATAGGC GTACAAAACA GTATTAAAGC TCAGTGTTTT GCATATTGTT AGCATTTACA 4140

AATATTTTTG CTTTAGTATG AGGAAAGTAA GGATGGGCAA AGAAGCGATC AAAATAGCTA 4200

TTGCTACAAC ATTTTCGAAA ACAAAGTTGG GGCTGTATTT CTTTAAAAAG ATAAGCCTCT 4260 AAAAATGCTT GGCAAAAAAA ATATAGTGTT AAAATAGGCC AGTGATATTA ATGAGAAAAT 4320

GAAAGTATGT ATCAGGAATA AAGTGATATT GCATAGGAGT ATTGTATTTT TATGAATTTT 4380

ATGCCAGTTG TTTACATGTA CTATATATGT TAAATTAAAA AAAATCATGA GAAATG

Seq ID NO: 499 Protein sequence Protein Accession ft: BAA74900.1

1 11 21 31 41 51

I I I I I I

PLVINTLKRF NLYPEVILAS WYRIYTKIMD LIGIQTKICW TVTRGEGLSP IESCEGLGDP 60

ACFYVAVIFI LNGLMMALFF IYGTYLSGSR LGGLVTVLCF FFNHGECTRV MWTPPLRESF 120

SYPFLVLQML LVTHILRATK LYRGSLIALC ISNVFFMLPW QFAQFVLLTQ IASLFAVYW 180

GYIDICKLRK IIYIHMISLA LCFVLMFGNS MLLTSYYASS LVIIWGILAM KPHFLKINVS 240

ELSLWVIQGC FWLFGTVILK YLTSKIFGIA DDAHIGNLLT SKFFSYKDFD TLLYTCAAEF 300

DFMEKETPLR YTKTLLLPW LWFVAIVRK IISDMWGVLA KQQTHVRKHQ FDHGELVYHA 360

LQLLAYTALG ILIMRLKLFL TPHMCVMASL ICSRQLFGWL FCKVHPGAIV FAILAAMSIQ 420

GSANLQTQWN IVGEFSNLPQ EELIEWIKYS TKPDAVFAGA MPTMASVKLS ALRPIVNHPH 480

YEDAGLRART KIVYSMYSRK AAEEVKRELI KLKVNYYILE ESWCVRRSKP GCSMPEIWDV 540 EDPANAGKTP LCNLLVKDSK PHFTTVFQNS VYKVLEWKE

Seq ID NO: 500 DNA sequence

Nucleic Acid Accession ft: NM_001276.1

Coding sequence: 127..1278

1 11 21 31 41 51 I I I I I I

AGTGGAGTGG GACAGGTATA TAAAGGAAGT ACAGGGCCTG GGGAAGAGGC CCTGTCTAGG 60 TAGCTGGCAC CAGGAGCCGT GGGCAAGGGA AGAGGCCACA CCCTGCCCTG CTCTGCTGCA 120 GCCAGAATGG GTGTGAAGGC GTCTCAAACA GGCTTTGTGG TCCTGGTGCT GCTCCAGTGC 180

TGCTCTGCAT ACAAACTGGT CTGCTACTAC ACCAGCTGGT CCCAGTACCG GGAAGGCGAT 240

GGGAGCTGCT TCCCAGATGC CCTTGACCGC TTCCTCTGTA CCCACATCAT CTACAGCTTT 300

GCCAATATAA GCAACGATCA CATCGACACC TGGGAGTGGA ATGATGTGAC GCTCTACGGC 360

ATGCTCAACA CACTCAAGAA CAGGAACCCC AACCTGAAGA CTCTCTTGTC TGTCGGAGGA 420

TGGAACTTTG GGTCTCAAAG ATTTTCCAAG ATAGCCTCCA ACACCCAGAG TCGCCGGACT 480

TTCATCAAGT CAGTACCGCC ATTCCTGCGC ACCCATGGCT TTGATGGGCT GGACCTTGCC 540

TGGCTCTACC CTGGACGGAG AGACAAACAG CATTTTACCA CCCTAATCAA GGAAATGAAG 600

GCCGAATTTA TAAAGGAAGC CCAGCCAGGG AAAAAGCAGC TCCTGCTCAG CGCAGCACTG 660

TCTGCGGGGA AGGTCACCAT TGACAGCAGC TATGACATTG CCAAGATATC CCAACACCTG 720

GATTTCATTA GCATCATGAC CTACGATTTT CATGGAGCCT GGCGTGGGAC CACAGGCCAT 780

CACAGTCCCC TGTTCCGAGG TCAGGAGGAT GCAAGTCCTG ACAGATTCAG CAACACTGAC 840

TATGCTGTGG GGTACATGTT GAGGCTGGGG GCTCCTGCCA GTAAGCTGGT GATGGGCATC 900

CCCACCTTCG GGAGGAGCTT CACTCTGGCT TCTTCTGAGA CTGGTGTTGG AGCCCCAATC 960

TCAGGACCGG GAATTCCAGG CCGGTTCACC AAGGAGGCAG GGACCCTTGC CTACTATGAG 1020

ATCTGTGACT TCCTCCGCGG AGCCACAGTC CATAGAACCC TCGGCCAGCA GGTCCCCTAT 1080

GCCACCAAGG GCAACCAGTG GGTAGGATAC GACGACCAGG AAAGCGTCAA AAGCAAGGTG 114,0

CAGTACCTGA AGGATAGGCA GCTGGCAGGC GCCATGGTAT GGGCCCTGGA CCTGGATGAC 1200

TTCCAGGGCT CCTTCTGCGG CCAGGATCTG CGCTTCCCTC TCACCAATGC CATCAAGGAT 1260

GCACTCGCTG CAACGTAGCC CTCTGTTCTG CACACAGCAC GGGGGCCAAG GATGCCCCGT 1320

CCCCCTCTGG CTCCAGCTGG CCGGGAGCCT GATCACCTGC CCTGCTGAGT CCCAGGCTGA 1380

GCCTCAGTCT CCCTCCCTTG GGGCCTATGC AGAGGTCCAC AACACACAGA TTTGAGCTCA 1440

GCCCTGGTGG GCAGAGAGGT AGGGATGGGG CTGTGGGGAT AGTGAGGCAT CGCAATGTAA 1500

GACTCGGGAT TAGTACACAC TTGTTGATGA TTAATGGAAA TGTTTACAGA TCCCCAAGCC 1560

TGGCAAGGGA ATTTCTTCAA CTCCCTGCCC CCTAGCCCTC CTTATCAAAG GACACCATTT 1620

TGGCAAGCTC TATCACCAAG GAGCCAAACA TCCTACAAGA CACAGTGACC ATACTAATTA 1680

TACCCCCTGC AAAGCCAGCT TGAAACCTTC ACTTAGGAAC GTAATCGTGT CCCCTATCCT 1740

ACTTCCCCTT CCTAATTCCA CAGCTGCTCA ATAAAGTACA AGAGTTTAAC AGTGTGTTGG 1800

CGCTTTGCTT TGGTCTATCT TTGAGCGCCC ACTAGACCCA CTGGACTCAC CTCCCCCATC 1860

TCTTCTGGGT TCCTTCCTCT GAGCCTTGGG ACCCCTGAGC TTGCAGAGAT GAAGGCCGCC 1920 ATGTT

Seq ID NO: 501 Protein sequence Protein Accession ft: NP_001267.1

1 11 21 31 41 51

I I I I I I

MGVKASQTGF WLVLLQCCS AYKLVCYYTS WSQYREGDGS CFPDALDRFL CTHIIYSFAN 60

ISNDHIDTWE WNDVTLYGML NTLKNRNPNL KTLLSVGGWN FGSQRFSKIA SNTQSRRTFI 120

KSVPPFLRTH GFDGLDLAWL YPGRRDKQHF TTLIKEMKAE FIKEAQPGKK QLLLSAALSA 180

GKVTIDSSYD IAKISQHLDF ISIMTYDFHG AWRGTTGHHS PLFRGQEDAS PDRFSNTDYA 240

VGYMLRLGAP ASKLVMGIPT FGRSFTLASS ETGVGAPISG PGIPGRFTKE AGTLAYYEIC 300

DFLRGATVHR TLGQQVPYAT KGNQWVGYDD QESVKSKVQY LKDRQLAGAM VWALDLDDFQ 360 GSFCGQDLRF PLTNAIKDAL AAT

Seq ID NO: 502 DNA sequence

Nucleic Acid Accession ft: NM_006474.1

Coding sequence: 181..669

1 11 21 31 41 51

I I I I I I

GCTGCCTAGG GTCTGGAAAG CTCGGGCACC CTCCCTCTCC GGGGCTCCTG CTCCCACCCC 60

TCCGGCCCCC CCACCGTCGC GCTCCTCCAG GCTGGGCCTG TGGCCGCGGT GCTTTTAATT 120

TTCCCCCAGC TCAGAATCTT GCTGCTCGGC CCCCAGGAGA GCAACAACTC AACGGGAACG 180

ATGTGGAAGG TGTCAGCTCT GCTCTTCGTT TTGGGAAGCG CGTCGCTCTG GGTCCTGGCA 240

GAAGGAGCCA GCACAGGCCA GCCAGAAGAT GACACTGAGA CTACAGGTTT GGAAGGCGGC 300

GTTGCCATGC CAGGTGCCGA AGATGATGTG GTGACTCCAG GAACCAGCGA AGACCGCTAT 360

AAGTCTGGCT TGACAACTCT GGTGGCAACA AGTGTCAACA GTGTAACAGG CATTCGCATC 420

GAGGATCTGC CAACTTCAGA AAGCACAGTC CACGCGCAAG AACAAAGTCC AAGCGCCACA 480

GCCTCAAACG TGGCCACCAG TCACTCCACG GAGAAAGTGG ATGGAGACAC ACAGACAACA 540

GTTGAGAAAG ATGGTTTGTC AACAGTGACC CTGGTTGGAA TCATAGTTGG GGTCTTACTA 600

GCCATCGGTT TCATTGGTGG AATCATCGTT GTGGTTATGC GAAAAATGTC GGGAAGGTAC 660

TCGCCCTAAA GAGCTGAAGG GTTACGCCCT GCTTGCCAAC GTGCTTTAAA AAAAGACCGT 720

TTCTGACTCT GTGGCCCTGT CCCTGAGCTC GTGGGGAGAA GATGACCCTG GGAACATTTG 780

CGGGCCCATT CAGATTCCAC GGTGACTTTC CGTTTGCCAA ATTAACCGAG GAAAGACCTT 840 TCACCAGATT TGGTTCTTAA ACTTT

Seq ID NO: 503 Protein sequence Protein Accession ft: NP_006465.1

1 11 21 31 41 51

I I I I I I

MWKVSALLFV LGSASLWVLA EGASTGQPED DTETTGLEGG VAMPGAEDDV VTPGTSEDRY 60

KSGLTTLVAT SVNSVTGIRI EDLPTSESTV HAQEQSPSAT ASNVATSHST EKVDGDTQTT 120 VEKDGLSTVT LVGIIVGVLL AIGFIGGIIV WMRKMSGRY SP

Seq ID NO: 504 DNA sequence .

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 62.-895

1 11 21 31 41 51

I I I I I

CACTGCTCTG AGAATTTGTG AGCAGCCCCT AACAGGCTGT TACTTCACTA CAACTGACGA 60

TATGATCATC TTAATTTACT TATTTCTCTT GCTATGGGAA GACACTCAAG GATGGGGATT 120

CAAGGATGGA ATTTTTCATA ACTCCATATG GCTTGAACGA GCAGCCGGTG TGTACCACAG 180

AGAAGCACGG TCTGGCAAAT ACAAGCTCAC CTACGCAGAA GCTAAGGCGG TGTGTGAATT 240

TGAAGGCGGC CATCTCGCAA CTTACAAGCA GCTAGAGGCA GCCAGAAAAA TTGGATTTCA 300 TGTCTGTGCT GCTGGATGGA TGGCTAAGGG CAGAGTTGGA TACCCCATTG TGAAGCCAGG 360

GCCCAACTGT GGATTTGGAA AAACTGGCAT TATTGATTAT GGAATCCGTC TCAATAGGAG 420

TGAAAGATGG GATGCCTATT GCTACAACCC ACACGCAAAG GAGTGTGGTG GCGTCTTTAC 480

AGATCCAAAG CAAATTTTTA AATCTCCAGG CTTCCCAAAT GAGTACGAAG ATAACCAAAT 540

CTGCTACTGG CACATTAGAC TCAAGTATGG TCAGCGTATT CACCTGAGTT TTTTAGATTT 600

TGACCTTGAA GATGACCCAG GTTGCTTGGC TGATTATGTT GAAATATATG ACAGTTACGA 660

TGATGTCCAT GGCTTTGTGG GAAGATACTG TGGAGATGAG CTTCCAGATG ACATCATCAG 720

TACAGGAAAT GTCATGACCT TGAAGTTTCT AAGTGATGCT TCAGTGACAG CTGGAGGTTT 780

CCAAATCAAA TATGTTGCAA TGGATCCTGT ATCCAAATCC AGTCAAGGAA AAAATACAAG 840

10 TACTACTTCT ACTGGAAATA AAAACTTTTT AGCTGGAAGA TTTAGCCACT TATAAAAAAA 900

AAAAAAAGGA TGATCAAAAC ACACAGTGTT TATGTTGGAA TCTTTTGGAA CTCCTTTGAT 960

CTCACTGTTA TTATTAACAT TTATTTATTA TTTTTCTAAA TGTGAAAGCA ATACATAATT 1020

TAGGGAAAAT TGGAAAATAT AGGAAACTTT AAACGAGAAA ATGAAACCTC TCATAATCCC 1080

ACTGCATAGA AATAACAAGC GTTAACATTT TCATATTTTT TTCTTTCAGT CATTTTTCTA 1140

15 TTTGTGGTAT ATGTATATAT GTACCTATAT GTATTTGCAT TTGAAATTTT GGAATCCTGC 1200

TCTATGTACA GTTTTGTATT ATACTTTTTA AATCTTGAAC TTTATAAACA TTTTCTGAAA 1260

TCATTGATTA TTCTACAAAA ACATGATTTT AAACAGCTGT AAAATATTCT ATGATATGAA 1320

TGTTTTATGC ATTATTTAAG CCTGTCTCTA TTGTTGGAAT TTCAGGTCAT TTTCATAAAT 1380 ATTGTTGCAA TAAATATCCT TGAACACACA AAAAAAAAAA AA

20

Seq ID NO: 505 Protein sequence Protein Accession ft : Eos sequence

__ 1 11 21 31 41 51

25 ] ] I I I I

MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT YAEAKAVCEF 60

EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNCGFGKTGI IDYGIRLNRS 120

ERWDAYCYNP HAKECGGVFT DPKQIFKSPG FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF ^" 180

DLEDDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF 240

30 QIKYVAMDPV SKSSQGKNTS TTSTGNKNFL AGRFSHL

Seq ID NO: 506 DNA sequence

Nucleic Acid Accession ft: NM_007115.1

Coding sequence: 69..902

35

1 11 21 31 41 51

I I I I I I

GAATTCGCAC TGCTCTGAGA ATTTGTGAGC AGCCCCTAAC AGGCTGTTAC TTCACTACAA 60

CTGACGATAT GATCATCTTA ATTTACTTAT TTCTCTTGCT ATGGGAAGAC ACTCAAGGAT 120

40 GGGGATTCAA GGATGGAATT TTTCATAACT CCATATGGCT TGAACGAGCA GCCGGTGTGT 180

ACCACAGAGA AGCACGGTCT GGCAAATACA AGCTCACCTA CGCAGAAGCT AAGGCGGTGT 240

GTGAATTTGA AGGCGGCCAT CTCGCAACTT ACAAGCAGCT AGAGGCAGCC AGAAAAATTG 300

GATTTCATGT CTGTGCTGCT GGATGGATGG CTAAGGGCAG AGTTGGATAC CCCATTGTGA 360

AGCCAGGGCC CAACTGATGA TTTGGAAAAA CTGGCATTAT TGATTATGGA ATCCGTCTCA 420

45 ATAGGAGTGA AAGATGGGAT GCCTATTGCT ACAACCCACA CGCAAAGGAG TGTGGTGGCG 480

TGTTTACAGA TCCAAAGCGA ATTTTTAAAT CTCCAGGCTT CCCAAATGAG TACGAAGATA 540

ACCAAATCTG CTACTGGCAC ATTAGACTCA AGTATGGTCA GCGTATTCAC CTGAGTTTTT 600

TAGATTTTGA CCTTGAAGAT GACCCAGGTT GCTTGGCTGA TTATGTTGAA ATATATGACA 660

GTTACGATGA TGTCCATGGC TTTGTGGGAA GATACTGTGG AGATGAGCTT CCAGATGACA 720

50 TCATCAGTAC AGGAAATGTC ATGACCTTGA AGTTTCTAAG TGATGCTTCA GTGACAGCTG 780

GAGGTTTCCA AATCAAATAT GTTGCAATGG ATCCTGTATC CAAATCCAGT CAAGGAAAAA 840

ATACAAGTAC TACTTCTACT GGAAATAAAA ACTTTTTAGC TGGAAGATTT AGCCACTTAT 900

AAAAAAAAAA AAGGATGATG AAAACACACA GTGTTTATGT TGGAATCTTT TGGAACTCCT 960

TTGATCTCAC TGTTATTATT AACATTTATT TATTATTTTT CTAAATGTGA AAGAAATACA 1020

55 TAATTTAGGG AAAATTGGAA AATATAGGAA ACTTTAAACG AGAAAATGAA ACCTCTCATA 1080

ATCCCACTGC ATAGAAATAA CAAGCGTTAA CATTTTCATA TTTTTTTCTT TCAGTCATTT 1140

TTGTATTTGT GGTATATGTA TATATGTACC TATATGTATT TGCATTTGAA ATTTTGGAAT 1200

, CCTGCTCTAT GTACAGTTTT GTATTATACT TTTTAAATCT TGAACTTTAT GAACATTTTC 1260

TGAAATCATT GATTATTCTA CAAAAACATG ATTTTAAACA GCTCTAAAAT ATTCTATGAT 1320

60 ATGAATGTTT TATGCATTAT TTAAGCCTGT CTCTATTGTT GGAATTTCAG GTCATTTTCA 1380 TAAATATTGT TGCAATAAAT ATCCTTCGGA ATTC

Seq ID NO: 507 Protein sequence Protein Accession ft: NP 009046.1

65

1 11 21 31 41 51

I I I I I I

MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT YAEAKAVCEF 60

_ EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNXXFGKTGI IDYGIRLNRS 120

70 ERWDAYCYNP HAKECGGVFT DPKRIFKSPG FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF 180

DLEDDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF 240

QIKYVAMDPV SKSSQGKNTS TTSTGNKNFL AGRFSHL

ID Seq ID NO: 508 DNA sequence

Nucleic Acid Accession ft: NM_001044.1 Coding sequence: 129..1991

_- 1 11 21 31 41 51

80 i i i i i i

ACCGCTCCGG AGCGGGAGGG GAGGCTTCGC GGAACGCTCT CGGCGCCAGG ACTCGCGTGC 60

AAAGCCCAGG CCCGGGCGGC CAGACCAAGA GGGAAGAAGC ACAGAATTCC TCAACTCCCA 120

GTGTGCCCAT GAGTAAGAGC AAATGCTCCG TGGGACTCAT GTCTTCCGTG GTGGCCCCGG 180

CTAAGGAGCC CAATGCCGTG GGCCCGAAGG AGGTGGAGCT CATCCTTGTC AAGGAGCAGA 240

85 ACGGAGTGCA GCTCACCAGC TCCACCCTCA CCAACCCGCG GCAGAGCCCC GTGGAGGCCC 300

AGGATCGGGA GACCTGGGGC AAGAAGATCG ACTTTCTCCT GTCCGTCATT GGCTTTGCTG 360

TGGACCTGGC CAACGTCTGG CGGTTCCCCT ACCTGTGCTA CAAAAATGGT GGCGGTGCCT 420 TCCTGGTCCC CTACCTGCTC TTCATGGTCA TTGCTGGGAT GCCACTTTTC TACATGGAGC 480

TGGCCCTCGG CCAGTTCAAC AGGGAAGGGG CCGCTGGTGT CTGGAAGATC TGCCCCATAC 540

TGAAAGGTGT GGGCTTCACG GTCATCCTCA TCTCACTGTA TGTCGGCTTC TTCTACAACG 600

TCATCATCGC CTGGGCGCTG CACTATCTCT TCTCCTCCTT CACCACGGAG CTCCCCTGGA 660

TCCACTGCAA CAACTCCTGG AACAGCCCCA ACTGCTCGGA TGCCCATCCT GGTGACTCCA 720

GTGGAGACAG CTCGGGCCTC AACGACACTT TTGGGACCAC ACCTGCTGCC GAGTACTTTG 780

AACGTGGCGT GCTGCACCTC CACCAGAGCC ATGGCATCGA CGACCTGGGG CCTCCGCGGT 840

GGCAGCTCAC AGCCTGCCTG GTGCTGGTCA TCGTGCTGCT CTACTTCAGC CTCTGGAAGG 900

GCGTGAAGAC CTCAGGGAAG GTGGTATGGA TCACAGCCAC CATGCCATAC GTGGTCCTCA 960

CTGCCCTGCT CCTGCGTGGG GTCACCCTCC CTGGAGCCAT AGACGGCATC AGAGCATACC 1020

TGAGCGTTGA CTTCTACCGG CTCTGCGAGG CGTCTGTTTG GATTGACGCG GCCACCCAGG 1080

TGTGCTTCTC CCTGGGCGTG GGGTTCGGGG TGCTGATCGC CTTCTCCAGC TACAACAAGT 1140

TCACCAACAA CTGCTACAGG GACGCGATTG TCACCACCTC CATCAACTCC CTGACGAGCT 1200

TCTCCTCCGG CTTCGTCGTC TTCTCCTTCC TGGGGTACAT GGCACAGAAG CACAGTGTGC 1260

CCATCGGGGA CGTGGCCAAG GACGGGCCAG GGCTGATCTT CATCATCTAC CCGGAAGCCA 1320

TCGCCACGCT CCCTCTGTCC TCAGCCTGGG CCGTGGTCTT CTTCATCATG CTGCTCACCC 1380

TGGGTATCGA CAGCGCCATG GGTGGTATGG AGTCAGTGAT CACCGGGCTC ATCGATGAGT 1440

TCCAGCTGCT GCACAGACAC CGTGAGCTCT TCACGCTCTT CATCGTCCTG GCGACCTTCC 1500

TCCTGTCCCT GTTCTGCGTC ACCAACGGTG GCATCTACGT CTTCACGCTC CTGGACCATT 1560

TTGCAGCCGG CACGTCCATC CTCTTTGGAG TGCTCATCGA AGCCATCGGA GTGGCCTGGT 1620

TCTATGGTGT TGGGCAGTTC AGCGACGACA TCCAGCAGAT GACCGGGCAG CGGCCCAGCC 1680

TGTACTGGCG GCTGTGCTGG AAGCTGGTCA GCCCCTGCTT TCTCCTGTTC GTGGTCGTGG 1740

TCAGCATTGT GACCTTCAGA CCCCCCCACT ACGGAGCCTA CATCTTCCCC GACTGGGCCA 1800

ACGCGCTGGG CTGGGTCATC GCCACATCCT CCATGGCCAT GGTGCCCATC TATGCGGCCT 1860

ACAAGTTCTG CAGCCTGCCT GGGTCCTTTC GAGAGAAACT GGCCTACGCC ATTGCACCCG 1920

AGAAGGACCG TGAGCTGGTG GACAGAGGGG AGGTGCGCCA GTTCACGCTC CGCCACTGGC 1980

TCAAGGTGTA GAGGGAGCAG AGACGAAGAC CCCAGGAAGT CATCCTGCAA TGGGAGAGAC 2040

ACGAACAAAC CAAGGAAATC TAAGTTTCGA GAGAAAGGAG GGCAACTTCT ACTCTTCAAC 2100

CTCTACTGAA AACACAAACA ACAAAGCAGA AGACTCCTCT CTTCTGACTG TTTACACCTT 2160

TCCGTGCCGG GAGCGCACCT CGCCGTGTCT TGTGTTGCTG TAATAACGAC GTAGATCTGT 2220

GCAGCGAGGT CCACCCCGTT GTTGTCCCTG CAGGGCAGAA AAACGTCTAA CTTCATGCTG 2280

TCTGTGTGAG GCTCCCTCCC TCCCTGCTCC CTGCTCCCGG CTCTGAGGCT GCCCCAGGGG 2340

CACTGTGTTC TCAGGCGGGG ATCACGATCC TTGTAGACGC ACCTGCTGAG AATCCCCGTG 2400

CTCACAGTAG CTTCCTAGAC CATTTACTTT GCCCATATTA AAAAGCCAAG TGTCCTGCTT 2460

GGTTTAGCTG TGCAGAAGGT GAAATGGAGG AAACCACAAA TTCATGGAAA GTCCTTTCCC 2520

GATGCGTGGC TCCCAGCAGA GGCCGTAAAT TGAGCGTTCA GTTGACACAT TGCACACACA 2580

GTCTGTTCAG AGGCATTGGA GGATGGGGGT CCTGGTATGT CTCACCAGGA AATTCTGTTT 2640

ATGTTCTTGC AGCAGAGAGA AATAAAACTC CTTGAAACCA GCTCAGGCTA CTGCCACTCA 2700

GGCAGCCTGT GGGTCCTTGT GGTGTAGGGA ACGGCCTGAG AGGAGCCTGT CCTATCCCCG 2760

GACGCATGCA GGGCCCCCAC AGGAGCGTGT CCTATCCCCG GACGCATGCA GGGCCCCCAC 2820

AGGAGCATGT CCTATCCCTG GACGCATGCA GGGCCCCCAC AGGAGCGTGT ACTACCCCAG 2880

AACGCATGCA GGGCCCCCAC AGGAGCGTGT ACTACCCCAG GACGCATGCA GGGCCCCCAC 2940

TGGAGCGTGT ACTACCCCAG GACGCATGCA GGGCCCCCAC AGGAGCGTGT CCTATCCCCG 3000

GACCGGACGC ATGCAGGGCC CCCAGAGGAG CGTGTACTAC CCCAGGACGC ATGCAGGGCC 3060

CCCACAGGAG CGTGTACTAC CCCAGGATGC ATGCAGGGCC CCCACAGGAG CGTGTACTAC 3120

CCCAGGACGC ATGCAGGGCC CCCATGCAGG CAGCCTGCAG ACCAACACTC TGCCTGGCCT 3180

TGAGCCGTGA CCTCCAGGAA GGGACCCCAC TGGAATTTTA TTTCTCTCAG GTGCGTGCCA 3240

CATCAATAAC AACAGTTTTT ATGTTTGCGA ATGGCTTTTT AAAATCATAT TTACCTGTGA 3300

ATCAAAACAA ATTCAAGAAT GCAGTATCCG CGAGCCTGCT TGCTGATATT GCAGTTTTTG 3360

TTTACAAGAA TAATTAGCAA TACTGAGTGA AGGATGTTGG CCAAAAGCTG CTTTCCATGG 3420

CACACTGCCC TCTGCCACTG ACAGGAAAGT GGATGCCATA GTTTGAATTC ATGCCTCAAG 3480

TCGGTGGGCC TGCCTACGTG CTGCCCGAGG GCAGGGGCCG TGCAGGGCCA GTCATGGCTG 3540

TCCCCTGCAA GTGGACGTGG GCTCCAGGGA CTGGAGTGTA ATGCTCGGTG GGAGCCGTCA 3600

GCCTGTGAAC TGCCAGGCAG CTGCAGTTAG CACAGAGGAT GGCTTCCCCA TTGCCTTCTG 3660

GGGAGGGACA CAGAGGACGG CTTCCCCATC GCCTTCTGGC CGCTGCAGTC AGCACAGAGA 3720

GCGGCTTCCC CATTGCCTTC TGGGGAGGGA CACAGAGGAC AGTTTCCCCA TCGCCTTCTG 3780

GTTGTTGAAG ACAGCACAGA GAGCGGCTTC CCCATCGCCT TCTGGGGAGG GGCTCCGTGT 3840

AGCAACCCAG GTGTTGTCCG TGTCTGTTGA CCAATCTCTA TTCAGCATCG TGTGGGTCCC 3900 TAAGCACAAT AAAAGACATC CACAATGGAA AAAAAAAAAG GAATTC

Seq ID NO: 509 Protein sequence Protein Accession ft: NP 001035.1

11 21 31 41 51

I I I I I I

MSKSKCSVGL MSSWAPAKE PNAVGPKEVE LILVKEQNGV QLTSSTLTNP RQSPVEAQDR 60 ETWGKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV PYLLFMVIAG MPLFYMELAL 120 GQFNREGAAG VWKICPILKG VGFTVILISL YVGFFYNVII AWALHYLFSS FTTELPWIHC 180 NNSWNSPNCS DAHPGDSSGD SSGLNDTFGT TPAAEYFERG VLHLHQSHGI DDLGPPRWQL 240 TACLVLVIVL LYFSLWKGVK TSGKWWITA TMPYWLTAL LLRGVTLPGA IDGIRAYLSV 300 DFYRLCEASV WIDAATQVCF SLGVGFGVLI AFSSYNKFTN NCYRDAIVTT SINSLTSFSS 360 GFWFSFLGY MAQKHSVPIG DVAKDGPGLI FIIYPEAIAT LPLSSAWAW FFIMLLTLGI 420 DSAMGGMESV ITGLIDEFQL LHRHRELFTL FIVLATFLLS LFCVTNGGIY VFTLLDHFAA 480 GTSILFGVLI EAIGVAWFYG VGQFSDDIQQ MTGQRPSLYW RLCWKLVSPC FLLFVWVSI 540 VTFRPPHYGA YIFPDWANAL GWVIATSSMA MVPIYAAYKF CSLPGSFREK LAYAIAPEKD 600 RELVDRGEVR QFTLRHWLKV

Seq ID NO: 510 DNA sequence Nucleic Acid Accession ft: NM_001216.1 Coding sequence: 43..1422

11 21 31 41 51 I

GCCCGTACAC ACCGTGTGCT GGGACACCCC ACAGTCAGCC GCATGGCTCC CCTGTGCCCC 60 AGCCCCTGGC TGCCTCTGTT GATCCCGGCC CCTGCTCCAG GCCTCACTGT GCAACTGCTG 120

CTGTCACTGC TGCTTCTGAT GCCTGTCCAT CCCCAGAGGT TGCCCCGGAT GCAGGAGGAT 180

TCCCCCTTGG GAGGAGGCTC TTCTGGGGAA GATGACCCAC TGGGCGAGGA GGATCTGCCC 240 AGTGAAGAGG ATTCACCCAG AGAGGAGGAT CCACCCGGAG AGGAGGATCT ACCTGGAGAG 300

GAGGATCTAC CTGGAGAGGA GGATCTACCT GAAGTTAAGC CTAAATCAGA AGAAGAGGGC 360

TCCCTGAAGT TAGAGGATCT ACCTACTGTT GAGGCTCCTG GAGATCCTCA AGAACCCCAG 420

AATAATGCCC ACAGGGACAA AGAAGGGGAT GACCAGAGTC ATTGGCGCTA TGGAGGCGAC 480

CCGCCCTGGC CCCGGGTGTC CCCAGCCTGC GCGGGCCGCT TCCAGTCCCC GGTGGATATC 540

CGCCCCCAGC TCGCCGCCTT CTGCCCGGCC CTGCGCCCCC TGGAACTCCT GGGCTTCCAG 600

CTCCCGCCGC TCCCAGAACT GCGCCTGCGC AACAATGGCC ACAGTGTGCA ACTGACCCTG 660

CCTCCTGGGC TAGAGATGGC TGTGGGTCCC GGGCGGGAGT ACCGGGCTCT GCAGCTGCAT 720

CTGCACTGGG GGGCTGCAGG TCGTCCGGGC TCGGAGCACA CTGTGGAAGG CCACCGTTTC 780

CCTGCCGAGA TCCACGTGGT TCACCTCAGC ACCGCCTTTG CCAGAGTTGA CGAGGCCTTG 840

GGGCGCCCGG GAGGCCTGGC CGTGTTGGCC GCCTTTCTGG AGGAGGGCCC GGAAGAAAAC 900

AGTGCCTATG AGCAGTTGCT GTCTCGCTTG GAAGAAATCG CTGAGGAAGG CTCAGAGACT 960

CAGGTCCCAG GACTGGACAT ATCTGCACTC CTGCCCTCTG ACTTCAGCCG CTACTTCCAA 1020

TATGAGGGGT CTCTGACTAC ACCGCCCTGT GCCCAGGGTG TCATCTGGAC TGTGTTTAAC 1080

CAGACAGTGA TGCTGAGTGC TAAGCAGCTC CACACCCTCT CTGACACCCT GTGGGGACCT 1140

GGTGACTCTC GGCTACAGCT GAACTTCCGA GCGACGCAGC CTTTGAATGG GCGAGTGATT 1200

GAGGCCTCCT TCCCTGCTGG AGTGGACAGC AGTCCTCGGG CTGCTGAGCC AGTCCAGCTG 1260

AATTCCTGCC TGGCTGCTGG TGACATCCTA GCCCTGGTTT TTGGCCTCCT TTTTGCTGTC 1320

ACCAGCGTCG CGTTCCTTGT GCAGATGAGA AGGCAGCACA GAAGGGGAAC CAAAGGGGGT 1380

GTGAGCTACC GCCCAGCAGA GGTAGCCGAG ACTGGAGCCT AGAGGCTGGA TCTTGGAGAA 1440

TGTGAGAAGC CAGCCAGAGG CATCTGAGGG GGAGCCGGTA ACTGTCCTGT CCTGCTCATT 1500 ATGCCACTTC CTTTTAACTG CCAAGAAATT TTTTAAAATA AATATTTATA AT

Seq ID NO: 511 Protein sequence Protein Accession ft: NP 001207.1

1 11 21 31 41 51 r i i i i i

MAPLCPSPWL PLLIPAPAPG LTVQLLLSLL LLMPVHPQRL PRMQEDSPLG GGSSGEDDPL 60 GEEDLPSEED SPREEDPPGE EDLPGEEDLP GEEDLPEVKP KSEEEGSLKL EDLPTVEAPG 120

DPQEPQNNAH RDKEGDDQSH WRYGGDPPWP RVSPACAGRF QSPVDIRPQL AAFCPALRPL 180

ELLGFQLPPL PBLRLRNNGH SVQLTLPPGL EMALGPGREY RALQLHLHWG AAGRPGSEHT 240

VEGHRFPAEI HWHLSTAFA RVDEALGRPG GLAVLAAFLE EGPEENSAYE QLLSRLEEIA 300

EEGSETQVPG LDISALLPSD FSRYFQYEGS LTTPPCAQGV IWTVFNQTVM LSAKQLHTLS 360 DTLWGPGDSR LQLNFRATQP LNGRVIEASF PAGVDSSPRA AEPVQLNSCL AAGDILALVF 420 GLLFAVTSVA FLVQMRRQHR RGTKGGVSYR PAEVAETGA

Seq ID NO: 512 DNA sequence Nucleic Acid Accession ft: Eos sequence Coding sequence: 1..3978

1 11 21 31 41 51

I I I I I I

ATGGTGGGTG AAGGACCCTA CCTTATCTCA GATCTGGACC AGCGAGGCCG GCGGAGATCC 60

TTTGCAGAAA GATATGACCC CAGCCTGAAG ACCATGATCC CAGTGCGACC CTGTGCAAGG 120

TTAGCACCCA ACCCGGTGGA TGATGCCGGG CTACTCTCCT TCGCCACATT TTCCTGGCTC 180

ACGCCGGTGA TGGTGAAAGG CTACCGGCAA AGGCTGACCG TAGACACCCT GCCCCCATTG 240

TCGACATATG ACTCATCTGA CACCAATGCC AAAAGATTTC GAGTCCTTTG GGATGAAGAG 300

GTAGCAAGGG TGGGTCCTGA GAAGGCCTCT CTGAGCCACG TGGTGTGGAA ATTCCAGAGG 360

ACACGCGTGT TGATGGACAT CGTGGCCAAC ATCCTGTGCA TCATCATGGC AGCCATAGGG 420

CCGACAGTTC TCATTCACCA AATCCTCCAG CAGACTGAGA GGACCTCTGG GAAAGTCTGG 480

GTTGGCATTG GACTGTGCAT AGCCCTTTTT GCCACCGAGT TTACCAAAGT CTTCTTTTGG 540

GCCCTTGCCT GGGCCATCAA CTACCGCACG GCCATCCGGT TGAAGGTGGC GCTCTCCACC 600

TTGGTTTTTG AAAACCTAGT GTCCTTCAAG ACATTGACCC ACATCTCTGT TGGCGAGGTG 660

CTCAATATAC TGTCAAGTGA TAGCTATTCT TTGTTTGAAG CTGCCTTGTT TTGTCCTTTG 720

CCAGCCACCA TCCCGATCCT AATGGTCTTT TGTGCGGCGT ACGCCTTTTT CATTCTGGGG 780

CCCACAGCTC TCATCGGGAT ATCAGTGTAT GTCATATTCA TACCCGTCCA GATGTTTATG 840

GCCAAGCTCA ATTCAGCTTT CCGAAGGTCA GCAATTTTGG TGACAGACAA GCGAGTTCAG 900

ACAATGAATG AGTTTCTGAC CTGCATCAGG CTGATCAAAA TGTATGCCTG GGAGAAATCT 960

TTTACCAACA CTATCCAAGA TATAAGAAGG AGGGAAAGAA AATTACTGGA AAAAGCTGGA 1020

TTTGTCCAAA GTGGAAACTC TGCCCTGGCC CCCATCGTGT CCACCATAGC CATCGTGCTG 1080

ACATTATCCT GCCACATCCT CCTGAGACGC AAACTCACCG CACCCGTGGC ATTTAGTGTG 1140

ATTGCCATGT TTAATGTAAT GAAGTTTTCC ATTGCAATCT TGCCCTTCTC CATCAAAGCA 1200

ATGGCTGAAG CGAATGTCTC TCTAAGGAGA ATGAAGAAAA TTCTCATAGA TAAAAGCCCC 1260

CCATCTTACA TCACCCAACC AGAAGACCCA GATACTGTCT TGCTTTTAGC AAATGCCACC 1320

TTGACATGGG AGCATGAAGC CAGCAGGAAA AGTACCCCAA AGAAATTGCA GAACCAGAAA 1380

AGGCATTTAT GCAAGAAACA GAGGTCAGAG GCATACAGTG AGAGGAGTCC ACCAGCCAAG 1440

GGAGCCACTG GCCCAGAGGA GCAAAGTGAC AGCCTCAAAT CGGTTCTGCA CAGCATAAGC 1500

TTTGTGGTGA GAAAGTTATG TCGTTATCCC GAAGCCCAGC TCCTGGCTTG GAGGTGGCCA 1560

GCAOTGTTTG TTGGGAGAAT CATCAGAGGA TACAGGCCTC ATGGATTTTC TGCTAAAGAC 1620

AAGGATGAAT CTAGAAGGCT TCTTACTTGG CCCCAAGAAG TGGATAGGAC TCAAAGGGCA 1680

GCCAAATACC TGGGGAAGAT CTTGGGAATA TGTGGGAATG TGGGAAGTGG AAAOAGCTCC 1740

CTCCTTGCAG CTCTCCTAGG ACAGATGCAG CTGCAGAAAG GGGTGGTGGC AGTCAATGGA 1800

ACTTTGGCCT ACGTTTCACA GCAGGCATGG ATCTTTCATG GAAATGTGAG AGAAAACATA 1860 CTCTTTGGAG AAAAGTATGA TCACCAAAGG TATCAGCACA CAGTCCGCGT CTGTGGCCTC 1920

CAGAAGGACC TGAGCAACCT CCCCTATGGA GACCTGACTG AGATTGGGGA GCGGGGCCTC 1980

AACCTCTCTG GGGGGCAGAG GCAGAGGATT AGCCTGGCCC GCGCTGTCTA CTCCGACCGT 2040

CAGCTCTACC TGCTGGACGA CCCCCTGTCG GCCGTGGACG CCCACGTGGG GAAGCACGTC 2100

TTTGAGGAGT GCATTAAGAA GACGCTCAGG GGAAAGACAG TCGTCCTGGT GACCCACCAG 2160 CTACAGTTCT TAGAGTCTTG TGATGAAGTT ATTTTATTAG AAGATGGAGA GATTTGTGAA 2220

AAGGGAACCC ACAAGGAGTT AATGGAGGAG AGAGGGCGCT ATGCAAAACT GATTCACAAC 2280

CTGCGAGGAT TGCAGTTCAA GGATCCTGAA CACCTTTACA ATGCAGCAAT GGTGGAAGCC 2340

TTCAAGGAGA GCCCTGCTGA GAGAGAGGAA GATGCTGGTA TAATCGGGTA CCTCCTTTCT 2400

CTCTTCACTG TGTTCCTCTT CCTCCTGATG ATTGGCAGCG CTGCCTTCAG CAACTGGTGG 2460 CTGGGTCTCT GGTTGGACAA GGGCTCACGG ATGACCTGTG GGCCCCAGGG CAACAGGACC 2520

ATGTGTGAGG TCGGCGCGGT GCTGGCAGAC ATCGGTCAGC ATGTGTACCA GTGGGTGTAC 2580

ACTGCAAGCA TGGTGTTCAT GCTGGTGTTT GGCGTCACCA AAGGCTTCGT CTTCACCAAG 2640 ACCACACTGA TGGCATCCTC CTCTCTGCAT GACACGGTGT TTGATAAGAT CTTAAAGAGC 2700

CCAATGAGTT TCTTTGACAC GACTCCCACT GGCAGGCTAA TGAACCGTTT TTCCAAGGAT 2760

ATGGACGAGC TGGATGTGAG GCTGCCGTTT CACGCAGAGA ACTTTCTGCA GCAGTTTTTT 2820

ATGGTGGTGT TTATTCTCGT GATCTTGGCT GCTGTGTTTC CTGCTGTCCT TTTAGTCGTG 2880

GCCAGCCTTG CTGTAGGCTT CTTCATTCTG TTACGCATTT TCCACAGAGG AGTCCAGGAG 2940

GTCAAGAAGG TGGAGAATGT CAGCCGGTCA CCCTGGTTCA CCCACATCAC CTCCTCCATG 3000

CAGGGCCTGG GCATCATTCA CGCCTATGGC AAGAAGGAGA GCTGCATCAC CTATACTTCA 3060

TCCAAAGGCC TGTCATTGTC ATACATCATC CAGCTGAGCG GACTGCTCCA AGTGTGTGTG 3120

CGAACGGGAA CAGAGACGCA AGCCAAATTC ACCTCCGTGG AGCTGCTCAG GGAATACATT 3180

10 TCGACCTGTG TTCCTGAATG CACTCATCCC CTCAAAGTGG GGACCTGTCC CAAGGACTGG 3240

CCCAGCTGTG GGGAGATCAC CTTCAGAGAC TATCAGATGA GATACAGAGA CAACACCCCC 3300

CTTGTTCTCG ACAGCCTGAA CTTGAACATA CAAAGTGGGC AGACAGTCGG GATTGTTGGA 3360

AGAACAGGTT CCGGAAAGTC ATCGTTAGGA ATGGCTTTGT TTCGTCTGGT GGAGCCAGCC 3420

AGTGGCACAA TCTTTATTGA TGAGGTGGAT ATCTGCATTC TCAGCTTGGA AGACCTCAGA 3480

15 ACCAAGCTGA CTGTGATCCC ACAGGATCCT GTCCTGTTTG TAGGTACAGT AAGGTACAAC 3540

TTGGATCCCT TTGAGAGTCA CACCGATGAG ATGCTCTGGC AGGTTCTGGA GAGAACATTC 3600

ATGAGAGACA CAATAATGAA ACTCCCAGAA AAATTACAGG CAGAAGTCAC AGAAAATGGA 3660

GAAAACTTCT CAGTAGGGGA ACGTCAGCTG CTTTGTGTGG CCCGAGCTCT TCTCCGTAAT 3720

TCAAAGATCA TTCTCCTTGA TGAAGCCACC GCCTCTATGG ACTCCAAGAC TGACACCCTG 3780

20 GTTCAGAACA CCATCAAAGA TGCCTTCAAG GGCTGCACTG TGCTGACCAT CGCCCACCGC 3840

CTCAACACAG TTCTCAACTG CGATCACGTC CTGGTTATGG AAAATGGGAA GGTGATTGAG 3900

TTTGACAAGC CTGAAGTCCT TGCAGAGAAG CCAGATTCTG CATTTGCGAT GTTACTAGCA 3960 GCAGAAGTCA GATTGTAG

25 Seq ID NO: 513 Protein sequence Protein Accession ft: Eos sequence

11 21 31 41 51

30 I I

MVGEGPYLIS DLDQRGRRRS F IAERYDPSLK T IMIPVRPCAR LAPNPVDDAG LLSFATFSWL 60 TPVMVKGYRQ RLTVDTLPPL STYDSSDTNA KRFRVLWDEE VARVGPEKAS LSHWWKFQR 120 TRVLMDIVAN ILCIIMAAIG PTVLIHQILQ QTERTSGKVW VGIGLCIALF ATEFTKVFFW 180 ALAWAINYRT AIRLKVALST LVFENLVSFK TLTHISVGEV LNILSSDSYS LFEAALFCPL 240 PATIPILMVF CAAYAFFILG PTALIGISVY VIFIPVQMFM AKLNSAFRRS AILVTDKRVQ 300

35 TMNEFLTCIR LIKMYAWEKS FTNTIQDIRR RERKLLEKAG FVQSGNSALA PIVSTIAIVL 360 TLSCHI LRR KLTAPVAFSV IAMFNVMKFS IAILPFSIKA MAEANVSLRR MKKILIDKSP 420 PSYITQPEDP DTVLLLANAT LTWEHEASRK STPKKLQNQK RHLCKKQRSE AYSERSPPAK 480 GATGPEEQSD SLKSVLHSIS FWRKLCRYP EAQLLAWRWP AVFVGRIIRG YRPHGFSAKD 540 KDESRRLLTW PQEVDRTQRA AKYLGKILGI CGNVGSGKSS LLAALLGQMQ LQKGWAVNG 600

40 TLAYVSQQAW IFHGNVRENI LFGEKYDHQR YQHTVRVCGL QKDLSNLPYG DLTEIGERGL 660 NLSGGQRQRI SLARAVYSDR QLYLLDDPLS AVDAHVGKHV FEECIKKTLR GKTWLVTHQ 720 LQFLESCDEV ILLEDGEICE KGTHKELMEE RGRYAKLIHN LRGLQFKDPE HLYNAAMVEA 780 FKESPAEREE DAGIIGYLLS LFTVFLFLLM IGSAAFSNWW LGLWLDKGSR MTCGPQGNRT 840 MCEVGAVLAD IGQHVYQWVY TASMVFMLVF GVTKGFVFTK TTLMASSSLH DTVFDKILKS 900

45 PMSFFDTTPT GRLMNRFSKD MDELDVRLPF HAENFLQQFF MWFILVILA AVFPAVLLW 960 ASLAVGFFIL LRIFHRGVQE LKKVENVSRS PWFTHITSSM QGLGIIHAYG KKESCITYTS 1020 SKGLSLSYII QLSGLLQVCV RTGTETQAKF TSVELLREYI STCVPECTHP LKVGTCPKDW 1080 PSCGEITFRD YQMRYRDNTP LVLDSLNLNI QSGQTVGIVG RTGSGKSSLG MALFRLVEPA 1140 SGTIFIDEVD ICILSLEDLR TKLTVIPQDP VLFVGTVRYN LDPFESHTDE MLWQVLERTF 1200

50 MRDTIMKLPE KLQAEVTENG ENFSVGERQL LCVARALLRN SKIILLDEAT ASMDSKTDTL 1260 VQNTIKDAFK GCTVLTIAHR LNTVLNCDHV LVMENGKVIE FDKPEVLAEK PDSAFAMLLA 1320 AEVRL

Seq ID NO: 514 DNA sequence 55 Nucleic Acid Accession ft: 231560 Coding sequence: 1-966

11 21 31 41 51

60 CACAGCGCCC G ICATGTACAA C IATGATGGAG A ICGGAGCTGA I

AGCCGCCGGG C ICCGCAGCAA 60 ACTTCGGGGG GCGGCGGCGG CAACTCCACC GCGGCGGCGG CCGGCGGCAA CCAGAAAAAC 120 AGCCCGGACC GCGTCAAGCG GCCCATGAAT GCCTTCATGG TGTGGTCCCG CGGGCAGCGG 180 CGCAAGATGG CCCAGGAGAA CCCCAAGATG CACAACTCGG AGATCAGCAA GCGCCTGGGC 240 GCCGAGTGGA AACTTTTGTC GGAGACGGAG AAGCGGCCGT TCATCGACGA GGCTAAGCGG 300

65 CTGCGAGCGC TGCACATGAA GGAGCACCCG GATTATAAAT ACCGGCCCCG GCGGAAAACC 360 AAGACGCTCA TGAAGAAGGA TAAGTACACG CTGCCCGGCG GGCTGCTGGC CCCCGGCGGC 420 AATAGCATGG CGAGCGGGGT CGGGGTGGGC GCCGGCCTGG GCGCGGGCGT GAACCAGCGC 480 ATGGACAGTT ACGCGCACAT GAACGGCTGG AGCAACGGCA GCTACAGCAT GATGCAGGAC 540 CAGCTGGGCT ACCCGCAGCA CCCGGGCCTC AATGCGCACG GCGCAGCGCA GATGCAGCCC 600

70 ATGCACCGCT ACGACGTGAG CGCCCTGCAG TACAACTCCA TGACCAGCTC GCAGACCTAC 660 ATGAACGGCT CGCCCACCTA CAGCATGTCC TACTCGCAGC AGGGCACCCC TGGCATGGCT 720 CTTGGCTCCA TGGGTTCGGT GGTCAAGTCC GAGGCCAGCT CCAGCCCCCC TGTGGTTACC 780 TCTTCCTCCC ACTCCAGGGC GCCCTGCCAG GCCGGGGACC TCCGGGACAT GATCAGCATG 840 TATCTCCCCG GCGCCGAGGT GCCGGAACCC GCCGCCCCCA GCAGACTTCA CATGTCCCAG 900

75 CACTACCAGA GCGGCCCGGT GCCCGGCACG GCCATTAACG GCACACTGCC CCTCTCACAC 960 ATGTGAGGGC CGGACAGCGA ACTGGAGGGG GGAGAAATTT TCAAAGAAAA ACGAGGGAAA 1020 TGGGAGGGGT GCAAAAGAGG AGAGTAAGAA ACAGCATGGA GAAAACCCGG TACGCTCAAA 1080 AAAAA

80 Seq ID NO: 515 Protein sequence Protein Accession ft: CAA83435

1 11 21 31 41 51 pr I I I I I I

O HSARMYNMME TELKPPGPQQ TSGGGGGNST AAAAGGNQKN SPDRVKRPMN AFMVWSRGQR 60 RKMAQENPKM HNSEISKRLG AEWKLLSETE KRPFIDEAKR LRALHMKEHP DYKYRPRRKT 120 KTLMKKDKYT LPGGLLAPGG NSMASGVGVG AGLGAGVNQR MDSYAHMNGW SNGSYSMMQD 180 QLGYPQHPGL NAHGAAQMQP MHRYDVSALQ YNSMTSSQTY MNGSPTYSMS YSQQGTPGMA 240 LGSMGSWKS EASSSPPWT SSSHSRAPCQ AGDLRDMISM YLPGAEVPEP AAPSRLHMSQ 300 HYQSGPVPGT AINGTLPLSH M

5 Seq ID NO: 516 DNA sequence

Nucleic Acid Accession ft: U91618 Coding sequence: 29..541

1 11 21 31 41 51

10 I I I I I I

CGGACTTGGC TTGTTAGAAG GCTGAAAGAT GATGGCAGGA ATGAAAATCC AGCTTGTATG 60

CATGCTACTC CTGGCTTTCA GCTCCTGGAG TCTGTGCTCA GATTCAGAAG AGGAAATGAA 120

AGCATTAGAA GCAGATTTCT TGACCAATAT GCATACATCA AAGATTAGTA AAGCACATGT 180

TCCCTCTTGG AAGATGACTC TGCTAAATGT TTGCAGTCTT GTAAATAATT TGAACAGCCC 240

15 AGCTGAGGAA ACAGGAGAAG TTCATGAAGA GGAGCTTGTT GCAAGAAGGA AACTTCCTAC 300

TGCTTTAGAT GGCTTTAGCT TGGAAGCAAT GTTGACAATA TACCAGCTCC ACAAAATCTG 360

TCACAGCAGG GCTTTTCAAC ACTGGGAGTT AATCCAGGAA GATATTCTTG ATACTGGAAA 420

TGACAAAAAT GGAAAGGAAG AAGTCATAAA GAGAAAAATT CCTTATATTC TGAAACGGCA 480

GCTGTATGAG AATAAACCCA GAAGACCCTA CATACTCAAA AGAGATTCTT ACTATTACTG 540

20 AGAGAATAAA TCATTTATTT ACATGTGATT GTGATTCATC ATCCCTTAAT TAAATATCAA 600

ATTATATTTG TGTGAAAATG TGACAAACAC ACTTATCTGT CTCTTCTACA ATTGTGGTTT 660

ATTGAATGTG TTTTTCTGCA CTAATAGAAA TTAGACTAAG TGTTTTCAAA TAAATCTAAA 720

TCTTCAAAAA AAAAAAAAAA AAATGGGGCC GCAATT

25 Seq ID NO: 517 Protein sequence Protein Accession ft: AAB50564

1 11 21 31 41 51

_ ,»_ΛU M IMAGMKIQLV C IMLLLAFSSW S ILCSDSEEEM K IALEADFLTN M 1HTSKISKAH V IPSWKMTLLN 60 VCSLVNNLNS PAEETGEVHE EELVARRKLP TALDGFSLEA MLTIYQLHKI CHSRAFQHWE 120 LIQEDILDTG NDKNGKEEVI KRKIPYILKR QLYENKPRRP YILKRDSYYY

Seq ID NO: 518 DNA sequence 35 Nucleic Acid Accession ft: NM_006536.2 Coding sequence: 109..2940

1 11 21 31 41 51

_An \ I I I I I

4U ACCTAAAACC TTGCAAGTTC AGGAAGAAAC CATCTGCATC CATATTGAAA ACCTGACACA 60

ATGTATGCAG CAGGCTCAGT GTGAGTGAAC TGGAGGCTTC TCTACAACAT GACCCAAAGG 120

AGCATTGCAG GTCCTATTTG CAACCTGAAG TTTGTGACTC TCCTGGTTGC CTTAAGTTCA 180

GAACTCCCAT TCCTGGGAGC TGGAGTACAG CTTCAAGACA ATGGGTATAA TGGATTGCTC 240

ATTGCAATTA ATCCTCAGGT ACCTGAGAAT CAGAACCTCA TCTCAAACAT TAAGGAAATG 300

45 ATAACTGAAG CTTCATTTTA CCTATTTAAT GCTACCAAGA GAAGAGTATT TTTCAGAAAT 360

ATAAAGATTT TAATACCTGC CACATGGAAA GCTAATAATA ACAGCAAAAT AAAACAAGAA 420

TCATATGAAA AGGCAAATGT CATAGTGACT GACTGGTATG GGGCACATGG AGATGATCCA 480

TACACCCTAC AATACAGAGG GTGTGGAAAA GAGGGAAAAT ACATTCATTT CACACCTAAT 540

TTCCTACTGA ATGATAACTT AACAGCTGGC TACGGATCAC GAGGCCGAGT GTTTGTCCAT 600

50 GAATGGGCCC ACCTCCGTTG GGGTGTGTTC GATGAGTATA ACAATGACAA ACCTTTCTAC 660

ATAAATGGGC AAAATCAAAT TAAAGTGACA AGGTGTTCAT CTGACATCAC AGGCATTTTT 720

GTGTGTGAAA AAGGTCCTTG CCCCCAAGAA AACTGTATTA TTAGTAAGCT TTTTAAAGAA 780

GGATGCACCT TTATCTACAA TAGCACCCAA AATGCAACTG CATCAATAAT GTTCATGCAA 840

AGTTTATCTT CTGTGGTTGA ATTTTGTAAT GCAAGTACCC ACAACCAAGA AGCACCAAAC 900

55 CTACAGAACC AGATGTGCAG CCTCAGAAGT GCATGGGATG TAATCACAGA CTCTGCTGAC 960

TTTCACCACA GCTTTCCCAT GAATGGGACT GAGCTTCCAC CTCCTCCCAC ATTCTCGCTT 1020

GTACAGGCTG GTGACAAAGT GGTCTGTTTA GTGCTGGATG TGTCCAGCAA GATGGCAGAG 1080

GCTGACAGAC TCCTTCAACT ACAACAAGCC GCAGAATTTT ATTTGATGCA GATTGTTGAA 1140

ATTCATACCT TCGTGGGCAT TGCCAGTTTC GACAGCAAAG GAGAGATCAG AGCCCAGCTA 1200

60 CACCAAATTA ACAGCAATGA TGATCGAAAG TTGCTGGTTT CATATCTGCC CACCACTGTA 1260

TCAGCTAAAA CAGACATCAG CATTTGTTCA GGGCTTAAGA AAGGATTTGA GGTGGTTGAA 1320

AAACTGAATG GAAAAGCTTA TGGCTCTGTG ATGATATTAG TGACCAGCGG AGATGATAAG 1380

CTTCTTGGCA ATTGCTTACC CACTGTGCTC AGCAGTGGTT CAACAATTCA CTCCATTGCC 1440

CTGGGTTCAT CTGCAGCCCC AAATCTGGAG GAATTATCAC GTCTTACAGG AGGTTTAAAG 1500

65 TTCTTTGTTC CAGATATATC AAACTCCAAT AGCATGATTG ATGCTTTCAG TAGAATTTCC 1560

TCTGGAACTG GAGACATTTT CCAGCAACAT ATTCAGCTTG AAAGTACAGG TGAAAATGTC 1620

AAACCTCACC ATCAATTGAA AAACACAGTG ACTGTGGATA ATACTGTGGG CAACGACACT 1680

ATGTTTCTAG TTACGTGGCA GGCCAGTGGT CCTCCTGAGA TTATATTATT TGATCCTGAT 1740

GGACGAAAAT ACTACACAAA TAATTTTATC ACCAATCTAA CTTTTCGGAC AGCTAGTCTT 1800

70 TGGATTCCAG GAACAGCTAA GCCTGGGCAC TGGACTTACA CCCTGAACAA TACCCATCAT 1860

TCTCTGCAAG CCCTGAAAGT GACAGTGACC TCTCGCGCCT CCAACTCAGC TGTGCCCCCA 1920

GCCACTGTGG AAGCCTTTGT GGAAAGAGAC AGCCTCCATT TTCCTCATCC TGTGATGATT 1980

TATGCCAATG TGAAACAGGG ATTTTATCCC ATTCTTAATG CCACTGTCAC TGCCACAGTT 2040

GAGCCAGAGA CTGGAGATCC TGTTACGCTG AGACTCCTTG ATGATGGAGC AGGTGCTGAT 2100

75 GTTATAAAAA ATGATGGAAT TTACTCGAGG TATTTTTTCT CCTTTGCTGC AAATGGTAGA 2160

TATAGCTTGA AAGTGCATGT CAATCACTCT CCCAGCATAA GCACCCCAGC CCACTCTATT 2220

CCAGGGAGTC ATGCTATGTA TGTACCAGGT TACACAGCAA ACGGTAATAT TCAGATGAAT 2280

GCTCCAAGGA AATCAGTAGG CAGAAATGAG GAGGAGCGAA AGTGGGGCTT TAGCCGAGTC 2340

AGCTCAGGAG GCTCCTTTTC AGTGCTGGGA GTTCCAGCTG GCCCCCACCC TGATGTGTTT 2400

80 CCACCATGCA AAATTATTGA CCTGGAAGCT GTAAAAGTAG AAGAGGAATT GACCCTATCT 2460

TGGACAGCAC CTGGAGAAGA CTTTGATCAG GGCCAGGCTA CAAGCTATGA AATAAGAATG 2520

AGTAAAAGTC TACAGAATAT CCAAGATGAC TTTAACAATG CTATTTTAGT AAATACATCA 2580

AAGCGAAATC CTCAGCAAGC TGGCATCAGG GAGATATTTA CGTTCTCACC CCAGATTTCC 2640

ACGAATGGAC CTGAACATCA GCCAAATGGA GAAACACATG AAAGCCACAG AATTTATGTT 2700

85 GCAATACGAG CAATGGATAG GAACTCCTTA CAGTCTGCTG TATCTAACAT TGCCCAGGCG 2760

CCTCTGTTTA TTCCCCCCAA TTCTGATCCT GTACCTGCCA GAGATTATCT TATATTGAAA 2820

GGAGTTTTAA CAGCAATGGG TTTGATAGGA ATCATTTGCC TTATTATAGT TGTGACACAT 2880 CATACTTTAA GCAGGAAAAA GAGAGCAGAC AAGAAAGAGA ATGGAACAAA ATTATTATAA 2940

ATAAATATCC AAAGTGTCTT CCTTCTTAGA TATAAGACCC ATGGCCTTCG ACTACAAAAA 3000

CATACTAACA AAGTCAAATT AACATCAAAA CTGTATTAAA ATGCATTGAG TTTTTGTACA 3060

ATACAGATAA GATTTTTACA TGGTAGATCA ACAATTCTTT TTGGGGGTAG ATTAGAAAAC 3120

CCTTACACTT TGGCTATGAA CAAATAATAA AAATTATTCT TTAAAGTAAT GTCTTTAAAG 3180

GCAAAGGGAA GGGTAAAGTC GGACCAGTGT CAAGGAAAGT TTGTTTTATT GAGGTGGAAA 3240

AATAGCCCCA AGCAGAGAAA AGGAGGGTAG GTCTGCATTA TAACTGTCTG TGTGAAGCAA 3300

TCATTTAGTT ACTTTGATTA ATTTTTCTTT TCTCCTTATC TGTGCAGTAC AGGTTGCTTG 3360

TTTACATGAA GATCATGCTA TATTTTATAT ATGTAGCCCC TAATGCAAAG CTCTTTACCT 3420

CTTGCTATTT TGTTATATAT ATTTCAGATG ACATCTCCCT GCTAATGCTC AGAGATCTTT 3480

TTTCACTGTA AGAGGTAACC TTTAACAATA TGGGTATTAC CTTTGTCTCT TCATACCGGT 3540

TTTATGACAA AGGTCTATTG AATTTATTTG TNTGTAAGTT TCTACTCCCA TCAAAGCAGC 3600

TTTCTAAGTT TATTGCCTTG GGTTATTATG GAATGATAGT TATAGCCCCN TATAATGCCT 3660 TACCTAGGAA A

Seq ID NO: 519 Protein sequence Protein Accession ft: NP 006527.1 1 11 21 31 41 51 i i i i i i

MTQRSIAGPI CNLKFVTLLV ALSSELPFLG AGVQLQDNGY NGLLIAINPQ VPENQNLISN 60

IKEMITEASF YLFNATKRRV FFRNIKILIP ATWKANNNSK IKQESYEKAN VIVTDWYGAH 120

GDDPYTLQYR GCGKEGKYIH FTPNFLLNDN LTAGYGSRGR VFVHEWAHLR WGVFDEYNND 180

KPFYINGQNQ IKVTRCSSDI TGIFVCEKGP CPQENCIISK LFKEGCTFIY NSTQNATASI 240

MFMQSLSSW EFCNASTHNQ EAPNLQNQMC SLRSAWDVIT DSADFHHSFP MNGTELPPPP 300

TFSLVQAGDK WCLVLDVSS KMAEADRLLQ LQQAAEFYLM QIVEIHTFVG IASFDSKGEI 360

RAQLHQINSN DDRKLLVSYL PTTVSAKTDI SICSGLKKGF EWEKLNGKA YGSVMILVTS 420

GDDKLLGNCL PTVLSSGSTI HSIALGSSAA PNLEELSRLT GGLKFFVPDI SNSNSMIDAF 480

SRISSGTGDI FQQHIQLEST GENVKPHHQL KNTVTVDNTV GNDTMFLVTW QASGPPEIIL 540

FDPDGRKYYT NNFITNLTFR TASLWIPGTA KPGHWTYTLN NTHHSLQALK VTVTSRASNS 600

AVPPATVEAF VERDSLHFPH PVMIYANVKQ GFYPILNATV TATVEPETGD PVTLRLLDDG 660

AGADVIKNDG IYSRYFFSFA ANGRYSLKVH VNHSPSISTP AHSIPGSHAM YVPGYTANGN 720

IQMNAPRKSV GRNEEERKWG FSRVSSGGSF SVLGVPAGPH PDVFPPCKII DLEAVKVEEE 780

LTLSWTAPGE DFDQGQATSY EIRMSKSLQN IQDDFNNAIL VNTSKRNPQQ AGIREIFTFS 840 PQISTNGPEH QPNGETHESH RIYVAIRAMD RNSLQSAVSN IAQAPLFIPP NSDPVPARDY 900 LILKGVLTAM GLIGIICLII WTHHTLSRK KRADKKENGT KLL

Seq ID NO: 520 DNA sequence Nucleic Acid Accession ft: NM_000228.1 Coding sequence: 82..3600

1 11 21 31 41 51

I I I I I I

GCTTTCAGGC GATCTGGAGA AAGAACGGCA GAACACACAG CAAGGAAAGG TCCTTTCTGG 60

GGATCACCCC ATTGGCTGAA GATGAGACCA TTCTTCCTCT TGTGTTTTGC CCTGCCTGGC 120

CTCCTGCATG CCCAACAAGC CTGCTCCCGT GGGGCCTGCT ATCCACCTGT TGGGGACCTG 180

CTTGTTGGGA GGACCCGGTT TCTCCGAGCT TCATCTACCT GTGGACTGAC CAAGCCTGAG 240

ACCTACTGCA CCCAGTATGG CGAGTGGCAG ATGAAATGCT GCAAGTGTGA CTCCAGGCAG 300

CCTCACAACT ACTACAGTCA CCGAGTAGAG AATGTGGCTT CATCCTCCGG CCCCATGCGC 360

TGGTGGCAGT CCCAGAATGA TGTGAACCCT GTCTCTCTGC AGCTGGACCT GGACAGGAGA 420

TTCCAGCTTC AAGAAGTCAT GATGGAGTTC CAGGGGCCCA TGCCCGCCGG CATGCTGATT 480

GAGCGCTCCT CAGACTTCGG TAAGACCTGG CGAGTGTACC AGTACCTGGC TGCCGACTGC 540

ACCTCCACCT TCCCTCGGGT CCGCCAGGGT CGGCCTCAGA GCTGGCAGGA TGTTCGGTGC 600

CAGTCCCTGC CTCAGAGGCC TAATGCACGC CTAAATGGGG GGAAGGTCCA ACTTAACCTT 660

ATGGATTTAG TGTCTGGGAT TCCAGCAACT CAAAGTCAAA AAATTCAAGA GGTGGGGGAG 720

ATCACAAACT TGAGAGTCAA TTTCACCAGG CTGGCCCCTG TGCCCCAAAG GGGCTACCAC 780

CCTCCCAGCG CCTACTATGC TGTGTCCCAG CTCCGTCTGC AGGGGAGCTG CTTCTGTCAC 840

GGCCATGCTG ATCGCTGCGC ACCCAAGCCT GGGGCCTCTG CAGGCCCCTC CACCGCTGTG 900

CAGGTCCACG ATGTCTGTGT CTGCCAGCAC AACACTGCCG GCCCAAATTG TGAGCGCTGT 960

GCACCCTTCT ACAACAACCG GCCCTGGAGA CCGGCGGAGG GCCAGGACGC CCATGAATGC 1020

CAAAGGTGCG ACTGCAATGG GCACTCAGAG ACATGTCACT TTGACCCCGC TGTGTTTGCC 1080

GCCAGCCAGG GGGCATATGG AGGTGTGTGT GACAATTGCC GGGACCACAC CGAAGGCAAG 1140

AACTGTGAGC GGTGTCAGCT GCACTATTTC CGGAACCGGC GCCCGGGAGC TTCCATTCAG 1200

GAGACCTGCA TCTCCTGCGA GTGTGATCCG GATGGGGCAG TGCCAGGGGC TCCCTGTGAC 1260

CCAGTGACCG GGCAGTGTGT GTGCAAGGAG CATGTGCAGG GAGAGCGCTG TGACCTATGC 1320

AAGCCGGGCT TCACTGGACT CACCTACGCC AACCCGCAGG GCTGCCACCG CTGTGACTGC 1380

AACATCCTGG GGTCCCGGAG GGACATGCCG TGTGACGAGG AGAGTGGGCG CTGCCTTTGT 1440

CTGCCCAACG TGGTGGGTCC CAAATGTGAC CAGTGTGCTC CCTACCACTG GAAGCTGGCC 1500

AGTGGCCAGG GCTGTGAACC GTGTGCCTGC GACCCGCACA ACTCCCCTCA GCCCACAGTG 1560

CAACCAGTTC ACAGGGCAGT GCCCTGTCGG GAAGGCTTTG GTGGCCTGAT GTGCAGCGCT 1620

GCAGCCATCC GCCAGTGTCC AGACCGGACC TATGGAGACG TGGCCACAGG ATGCCGAGCC 1680

TGTGACTGTG ATTTCCGGGG AACAGAGGGC CCGGGCTGCG ACAAGGCATC AGGCCGCTGC 1740

CTCTGCCGCC CTGGCTTGAC CGGGCCCCGC TGTGACCAGT GCCAGCGAGG CTACTGCAAT 1800

CGCTACCCGG TGTGCGTGGC CTGCCACCCT TGCTTCCAGA CCTATGATGC GGACCTCCGG 1860

GAGCAGGCCC TGCGCTTTGG TAGACTCCGC AATGCCACCG CCAGCCTGTG GTCAGGGCCT 1920

GGGCTGGAGG ACCGTGGCCT GGCCTCCCGG ATCCTAGATG CAAAGAGTAA GATTGAGCAG 1980

ATCCGAGCAG TTCTCAGCAG CCCCGCAGTC ACAGAGCAGG AGGTGGCTCA GGTGGCCAGT 2040

GCCATCCTCT CCCTCAGGCG AACTCTCCAG GGCCTGCAGC TGGATCTGCC CCTGGAGGAG 2100

GAGACGTTGT CCCTTCCGAG AGACCTGGAG AGTCTTGACA GAAGCTTCAA TGGTCTCCTT 2160

ACTATGTATC AGAGGAAGAG GGAGCAGTTT GAAAAAATAA GCAGTGCTGA TCCTTCAGGA 2220

GCCTTCCGGA TGCTGAGCAC AGCCTACGAG CAGTCAGCCC AGGCTGCTCA GCAGGTCTCC 2280

GACAGCTCGC GCCTTTTGGA CCAGCTCAGG GACAGCCGGA GAGAGGCAGA GAGGCTGGTG 2340

CGGCAGGCGG GAGGAGGAGG AGGCACCGGC AGCCCCAAGC TTGTGGCCCT GAGGCTGGAG 2400

ATGTCTTCGT TGCCTGACCT GACACCCACC TTCAACAAGC TCTGTGGCAA CTCCAGGCAG 2460 ATGGCTTGCA CCCCAATATC ATGCCCTGGT GAGCTATGTC CCCAAGACAA TGGCACAGCC 2520

TGTGGCTCCC GCTGCAGGGG TGTCCTTCCC AGGGCCGGTG GGGCCTTCTT GATGGCGGGG 2580

CAGGTGGCTG AGCAGCTGCG GGGCTTCAAT GCCCAGCTCC AGCGGACCAG GCAGATGATT 2640 AGGGCAGCCG AGGAATCTGC CTCACAGATT CAATCCAGTG CCCAGCGCTT GGAGACCCAG 2700

GTGAGCGCCA GCCGCTCCCA GATGGAGGAA GATGTCAGAC GCACACGGCT CCTAATCCAG 2760

CAGGTCCGGG ACTTCCTAAC AGACCCCGAC ACTGATGCAG CCACTATCCA GGAGGTCAGC 2820

GAGGCCGTGC TGGCCCTGTG GCTGCCCACA GACTCAGCTA CTGTTCTGCA GAAGATGAAT 2880

GAGATCCAGG CCATTGCAGC CAGGCTCCCC AACGTGGACT TGGTGCTGTC CCAGACCAAG 2940

CAGGACATTG CGCGTGCCCG CCGGTTGCAG GCTGAGGCTG AGGAAGCCAG GAGCCGAGCC 3000

CATGCAGTGG AGGGCCAGGT GGAAGATGTG GTTGGGAACC TGCGGCAGGG GACAGTGGCA 3060

CTGCAGGAAG CTCAGGACAC CATGCAAGGC ACCAGCCGCT CCCTTCGGCT TATCCAGGAC 3120

AGGGTTGCTG AGGTTCAGCA GGTACTGCGG CCAGCAGAAA AGCTGGTGAC AAGCATGACC 3180

AAGCAGCTGG GTGACTTCTG GACACGGATG GAGGAGCTCC GCCACCAAGC CCGGCAGCAG 3240

GGGGCAGAGG CAGTCCAGGC CCAGCAGCTT GCGGAAGGTG CCAGCGAGCA GGCATTGAGT 3300

GCCCAAGAGG GATTTGAGAG AATAAAACAA AAGTATGCTG AGTTGAAGGA CCGGTTGGGT 3360

CAGAGTTCCA TGCTGGGTGA GCAGGGTGCC CGGATCCAGA GTGTGAAGAC AGAGGCAGAG 3420

GAGCTGTTTG GGGAGACCAT GGAGATGATG GACAGGATGA AAGACATGGA GTTGGAGCTG 3480

CTGCGGGGCA GCCAGGCCAT CATGCTGCGC TCGGCGGACC TGACAGGACT GGAGAAGCGT 3540

GTGGAGCAGA TCCGTGACCA CATCAATGGG CGCGTGCTCT ACTATGCCAC CTGCAAGTGA 3600

TGCTACAGCT TCCAGCCCGT TGCCCCACTC ATCTGCCGCC TTTGCTTTTG GTTGGGGGCA 3660

GATTGGGTTG GAATGCTTTC CATCTCCAGG AGACTTTCAT GCAGCCTAAA GTACAGCCTG 3720

GACCACCCCT GGTGTGTAGC TAGTAAGATT ACCCTGAGCT GCAGCTGAGC CTGAGCCAAT 3780

GGGACAGTTA CACTTGACAG ACAAAGATGG TGGAGATTGG CATGCCATTG AAACTAAGAG 3840

CTCTCAAGTC AAGGAAGCTG GGCTGGGCAG TATCCCCCGC CTTTAGTTCT CCACTGGGGA 3900

GGAATCCTGG ACCAAGCACA AAAACTTAAC AAAAGTGATG TAAAAATGAA AAGCCAAATA 3960 AAAATCTTTG G

Seq ID NO: 521 Protein sequence Protein Accession ft: NP_000219.1

1 11 21 31 41 51

I I I I I I

MRPFFLLCFA LPGLLHAQQA CSRGACYPPV GDLLVGRTRF LRASSTCGLT KPETYCTQYG 60

EWQMKCCKCD SRQPHNYYSH RVENVASSSG PMRWWQSQND VNPVSLQLDL DRRFQLQEVM 120

MEFQGPMPAG MLIERSSDFG KTWRVYQYLA ADCTSTFPRV RQGRPQSWQD VRCQSLPQRP 180

NARLNGGKVQ LNLMDLVSGI PATQSQKIQE VGEITNLRVN FTRLAPVPQR GYHPPSAYYA 240

VSQLRLQGSC FCHGHADRCA PKPGASAGPS TAVQVHDVCV CQHNTAGPNC ERCAPFYNNR 300

PWRPAEGQDA HECQRCDCNG HSETCHFDPA VFAASQGAYG GVCDNCRDHT EGKNCERCQL 360

HYFRNRRPGA SIQETCISCE CDPDGAVPGA PCDPVTGQCV CKEHVQGERC DLCKPGFTGL 420

TYANPQGCHR CDCNILGSRR DMPCDEESGR CLCLPNWGP KCDQCAPYHW KLASGQGCEP 480

CACDPHNSPQ PTVQPVHRAV PCREGFGGLM CSAAAIRQCP DRTYGDVATG CRACDCDFRG 540

TEGPGCDKAS GRCLCRPGLT GPRCDQCQRG YCNRYPVCVA CHPCFQTYDA DLREQALRFG 600

RLRNATASLW SGPGLEDRGL ASRILDAKSK lEQIRAVLSS PAVTEQEVAQ VASAILSLRR 660

TLQGLQLDLP LEEETLSLPR DLESLDRSFN GLLTMYQRKR EQFEKISSAD PSGAFRMLST 720

AYEQSAQAAQ QVSDSSRLLD QLRDSRREAE RLVRQAGGGG GTGSPKLVAL RLEMSSLPDL 780

TPTFNKLCGN SRQMACTPIS CPGELCPQDN GTACGSRCRG VLPRAGGAFL MAGQVAEQLR 840

GFNAQLQRTR QMIRAAEESA SQIQSSAQRL ETQVSASRSQ MEEDVRRTRL LIQQVRDFLT 900

DPDTDAATIQ EVSEAVLALW LPTDSATVLQ KMNEIQAIAA RLPNVDLVLS QTKQDIARAR 960

RLQAEAEEAR SRAHAVEGQV ED GNLRQG TVALQEAQDT MQGTSRSLRL IQDRVAEVQQ 1020

VLRPAEKLVT SMTKQLGDFW TRMEELRHQA RQQGAEAVQA QQLAEGASEQ ALSAQEGFER 1080

IKQKYAELKD RLGQSSMLGE QGARIQSVKT EAEELFGETM EMMDRMKDME LELLRGSQAI 1140 MLRSADLTGL EKRVEQIRDH INGRVLYYAT CK

Seq ID NO: 522 DNA sequence

Nucleic Acid Accession ft: NM_001944.1

Coding sequence: 84.. 083

1 11 21 31 41 51

I I I I I I

TTTTCTTAGA CATTAACTGC AGACGGCTGG CAGGATAGAA GCAGCGGCTC ACTTGGACTT 60

TTTCACCAGG GAAATCAGAG ACAATGATGG GGCTCTTCCC CAGAACTACA GGGGCTCTGG "120

CCATCTTCGT GGTGGTGATA TTGGTTCATG GAGAATTGCG AATAGAGACT AAAGGTCAAT 180

ATGATGAAGA AGAGATGACT ATGCAACAAG CTAAAAGAAG GCAAAAACGT GAATGGGTGA 240

AATTTGCCAA ACCCTGCAGA GAAGGAGAAG ATAACTCAAA AAGAAACCCA ATTGCCAAGA 300

TTACTTCAGA TTACCAAGCA ACCCAGAAAA TCACCTACCG AATCTCTGGA GTGGGAATCG 360

ATCAGCCGCC TTTTGGAATC TTTGTTGTTG ACAAAAACAC TGGAGATATT AACATAACAG 420

CTATAGTCGA CCGGGAGGAA ACTCCAAGCT TCCTGATCAC ATGTCGGGCT CTAAATGCCC 480

AAGGACTAGA TGTAGAGAAA CCACTTATAC TAACGGTTAA AATTTTGGAT ATTAATGATA 540

ATCCTCCAGT ATTTTCACAA CAAATTTTCA TGGGTGAAAT TGAAGAAAAT AGTGCCTCAA 600

ACTCACTGGT GATGATACTA AATGCCACAG ATGCAGATGA ACCAAACCAC TTGAATTCTA 660

AAATTGCCTT CAAAATTGTC TCTCAGGAAC CAGCAGGCAC ACCCATGTTC CTCCTAAGCA 720

GAAACACTGG GGAAGTCCGT ACTTTGACCA ATTCTCTTGA CCGAGAGCAA GCTAGCAGCT 780

ATCGTCTGGT TGTGAGTGGT GCAGACAAAG ATGGAGAAGG ACTATCAACT CAATGTGAAT 840

GTAATATTAA AGTGAAAGAT GTCAACGATA ACTTCCCAAT GTTTAGAGAC TCTCAGTATT 900

CAGCACGTAT TGAAGAAAAT ATTTTAAGTT CTGAATTACT TCGATTTCAA GTAACAGATT 960

TGGATGAAGA GTACACAGAT AATTGGCTTG CAGTATATTT CTTTACCTCT GGGAATGAAG 1020

GAAATTGGTT TGAAATACAA ACTGATCCTA GAACTAATGA AGGCATCCTG AAAGTGGTGA 1080

AGGCTCTAGA TTATGAACAA CTACAAAGCG TGAAACTTAG TATTGCTGTC AAAAACAAAG 1140

CTGAATTTCA CCAATCAGTT ATCTCTCGAT ACCGAGTTCA GTCAACCCCA GTCACAATTC 1200

AGGTAATAAA TGTAAGAGAA GGAATTGCAT TCCGTCCTGC TTCCAAGACA TTTACTGTGC 1260

AAAAAGGCAT AAGTAGCAAA AAATTGGTGG ATTATATCCT GGGAACATAT CAAGCCATCG 1320

ATGAGGACAC TAACAAAGCT GCCTCAAATG TCAAATATGT CATGGGACGT AACGATGGTG 1380

GATACCTAAT GATTGATTCA AAAACTGCTG AAATCAAATT TGTCAAAAAT ATGAACCGAG 1440

ATTCTACTTT CATAGTTAAC AAAACAATCA CAGCTGAGGT TCTGGCCATA GATGAATACA 1500

CGGGTAAAAC TTCTACAGGC ACGGTATATG TTAGAGTACC CGATTTCAAT GACAATTGTC . 1560

CAACAGCTGT CCTCGAAAAA GATGCAGTTT GCAGTTCTTC ACCTTCCCTG GTTGTCTCCG 1620

CTAGAACACT GAATAATAGA TACACTGGCC CCTATACATT TGCACTGGAA GATCAACCTG 1680

TAAAGTTGCC TGCCGTATGG AGTATCACAA CCCTCAATGC TACCTCGGCC CTCCTCAGAG 1740

CCCAGGAACA GATACCTCCT GGAGTATACC ACATCTCCCT GGTACTTACA GACAGTCAGA 1800

ACAATCGGTG TGAGATGCCA CGCAGCTTGA CACTGGAAGT CTGTCAGTGT GACAACAGGG 1860 GCATCTGTGG AACTTCTTAC CCAACCACAA GCCCTGGGAC CAGGTATGGC AGGCCGCACT 1920

CAGGGAGGCT GGGGCCTGCC GCCATCGGCC TGCTGCTCCT TGGTCTCCTG CTGCTGCTGT 1980

TGGCCCCCCT TCTGCTGTTG ACCTGTGACT GTGGGGCAGG TTCTACTGGG GGAGTGACAG 2040

GTGGTTTTAT CCCAGTTCCT GATGGCTCAG AAGGAACAAT TCATCAGTGG GGAATTGAAG 2100

GAGCCCATCC TGAAGACAAG GAAATCACAA ATATTTGTGT GCCTCCTGTA AGAGCCAATG 2160

GAGCCGATTT CATGGAAAGT TCTGAAGTTT GTACAAATAC GTATGCCAGA GGCACAGCGG 2220

TGGAAGGCAC TTCAGGAATG GAAATGACCA CTAAGCTTGG AGCAGCCACT GAATCTGGAG 2280

GTGCTGCAGG CTTTGCAACA GGGACAGTGT CAGGAGCTGC TTCAGGATTC GGAGCAGCCA 2340

CTGGAGTTGG CATCTGTTCC TCAGGGCAGT CTGGAACCAT GAGAACAAGG CATTCCACTG 2400

10 GAGGAACCAA TAAGGACTAC GCTGATGGGG CGATAAGCAT GAATTTTCTG GACTCCTACT 2460

TTTCTCAGAA AGCATTTGCC TGTGCGGAGG AAGACGATGG CCAGGAAGCA AATGACTGCT 2520

TGTTGATCTA TGATAATGAA GGCGCAGATG CCACTGGTTC TCCTGTGGGC TCCGTGGGTT 2580

GTTGCAGTTT TATTGCTGAT GACCTGGATG ACAGCTTCTT GGACTCACTT GGACCCAAAT 2640

TTAAAAAACT TGCAGAGATA AGCCTTGGTG TTGATGGTGA AGGCAAAGAA GTTCAGCCAC 2700

15 CCTCTAAAGA CAGCGGTTAT GGGATTGAAT CCTGTGGCCA TCCCATAGAA GTCCAGCAGA 2760

CAGGATTTGT TAAGTGCCAG ACTTTGTCAG GAAGTCAAGG AGCTTCTGCT TTGTCCGCCT 2820

CTGGGTCTGT CCAGCCAGCT GTTTCCATCC CTGACCCTCT GCAGCATGGT AACTATTTAG 2880

TAACGGAGAC TTACTCGGCT TCTGGTTCCG TCGTGCAACC TTCCACTGCA GGCTTTGATC 2940

CACTTCTCAC ACAAAATGTG ATAGTGACAG AAAGGGTGAT CTGTCCCATT TCCAGTGTTC 3000

20 CTGGCAACCT AGCTGGCCCA ACGCAGCTAC GAGGGTCACA TACTATGCTC TGTACAGAGG 3060

ATCCTTGCTC CCGTCTAATA TGACCAGAAT GAGCTGGAAT ACCACACTGA CCAAATCTGG 3120

ATCTTTGGAC TAAAGTATTC AAAATAGCAT AGCAAAGCTC ACTGTATTGG GCTAATAATT 3180

TGGCACTTAT TAGCTTCTCT CATAAACTGA TCACGATTAT AAATTAAATG TTTGGGTTCA 3240

TACCCCAAAA GCAATATGTT GTCACTCCTA ATTCTCAAGT ACTATTCAAA TTGTAGTAAA 3300

25 TCTTAAAGTT TTTCAAAACC CTAAAATCAT ATTCGC

Seq ID NO: 523 Protein sequence Protein Accession ft: NP_001935.1

30 1 11 21 31 41 51

I I I I I I

MMGLFPRTTG ALAIFWVIL VHGELRIETK GQYDEEEMTM QQAKRRQKRE WVKFAKPCRE 60

GEDNSKRNPI AKITSDYQAT QKITYRISGV GIDQPPFGIF WDKNTGDIN ITAIVDREET 120

PSFLITCRAL NAQGLDVEKP LILTVKILDI NDNPPVFSQQ IFMGEIEENS ASNSLVMILN 180

35 ATDADEPNHL NSKIAFKIVS QEPAGTPMFL LSRNTGEVRT LTNSLDREQA SSYRLWSGA 240

DKDGEGLSTQ CECNIKVKDV NDNFPMFRDS QYSARIEENI LSSELLRFQV TDLDEEYTDN 300

WLAVYFFTSG NEGNWFEIQT DPRTNEGILK WKALDYEQL QSVKLSIAVK NKAEFHQSVI 360

SRYRVQSTPV TIQVINVREG IAFRPASKTF TVQKGISSKK LVDYILGTYQ AIDEDTNKAA 420

SNVKYVMGRN DGGYLMIDSK TAEIKFVKNM NRDSTFIVNK TITAEVLAID EYTGKTSTGT 480

40 VYVRVPDFND NCPTAVLEKD AVCSSSPSW VSARTLNNRY TGPYTFALED QPVKLPAVWS 540

ITTLNATSAL LRAQEQIPPG VYHISLVLTD SQNNRCEMPR SLTLEVCQCD NRGICGTSYP 600

TTSPGTRYGR PHSGRLGPAA IGLLLLGLLL LLLAPLLLLT CDCGAGSTGG VTGGFIPVPD 660

GSEGTIHQWG IEGAHPEDKE ITNICVPPVT ANGADFMESS EVCTNTYARG TAVEGTSGME 720

MTTKLGAATE SGGAAGFATG TVSGAASGFG AATGVGICSS GQSGTMRTRH STGGTNKDYA 780

45 DGAISMNFLD SYFSQKAFAC AEEDDGQEAN DCLLIYDNEG ADATGSPVGS VGCCSFIADD 840

LDDSFLDSLG PKFKKLAEIS LGVDGEGKEV QPPSKDSGYG IESCGHPIEV QQTGFVKCQT 900

LSGSQGASAL SASGSVQPAV SIPDPLQHGN YLVTETYSAS GSLVQPSTAG FDPLLTQNVI 960 VTERVICPIS SVPGNLAGPT QLRGSHTMLC TEDPCSRLI

50 Seq ID NO: 524 DNA sequence

Nucleic Acid Accession ft: XM_058069.2

Coding sequence: 1..1413

__ 1 11 21 31 41 51

55 i i i i i i

ATGAAGTTTC TTCTAA ACT GCTCCTGCAG GCCACTGCTT CTGGAGCTCT TCCCCTGAAC 60

AGCTCTACAA GGCTGGAAAA AAATAATGTG CTATTTGGTG AAAGATACTT AGAAAAATTT 120

TATGGCCTTG AGATAAACAA ACTTCCAGTG ACAAAAATGA AATATAGTGG AAACTTAATG 180

AAGGAAAAAA TCCAAGAAAT GCAGCACTTC TTGGGTCTGA AAGTGACCGG GCAACTGGAC 240

60 ACATCTACCC TGGAGATGAT GCACGCACCT CGATGTGGAG TCCCCGATGT CCATCATTTC 300

AGGGAAATGC CAGGGGGGCC CGTATGGAGG AAACATTATA TGACCTACAG AATCAATAAT 360

TACACACCTG ACATGAACCG TGAGGATGTT GACTACGCAA TCCGGAAAGC TTTCCAAGTA 420

TGGAGTAATG TTACCCCCTT GAAATTCAGC AAGATTAACA CAGGCATGGC TGACATTTTG 480

GTGGTTTTTG CCCGTGGAGC TCATGGAGAC TTCCATGCTT TTGATGGCAA AGGTGGAATC 540

65 CTAGCCCATG CTTTTGGACC TGGATCTGGC ATTGGAGGGG ATGCACATTT CGATGAGGAC 600

GAATTCTGGA CTACACATTC AGGAGGCACA AACTTGTTCC TCACTGCTGT TCACGAGATT 660

GGCCATTCCT TAGGTCTTGG CCATTCTAGT GATCCAAAGG CCGTAATGTT CCCCACCTAC 720

AAATATGTTG ACATCAACAC ATTTCGCCTC TCTGCTGATG ACATACGTGG CATTCAGTCC 780

CTGTATGGAG ACCCAAAAGA GAACCAACGC TTGCCAAATC CTGACAATTC AGAACCAGCT 840

70 CTCTGTGACC CCAATTTGAG TTTTGATGCT GTCACTACCG TGGGAAATAA GATCTTTTTC 900

TTCAAAGACA GGTTCTTCTG GCTGAAGGTT TCTGAGAGAC CAAAGACCAG TGTTAATTTA 960

ATTTCTTCCT TATGGCCAAC CTTGCCATCT GGCATTGAAG CTGCTTATGA AATTGAAGCC 1020

AGAAATCAAG TTTTTCTTTT TAAAGATGAC AAATACTGGT TAATTAGCAA TTTAAGACCA 1080

GAGCCAAATT ATCCCAAGAG CATACATTCT TTTGGTTTTC CTAACTTTGT GAAAAAAATT 1140

75 GATGCAGCTG TTTTTAACCC ACGTTTTTAT AGGACCTACT TCTTTGTAGA TAACCAGTAT 1200

TGGAGGTATG ATGAAAGGAG ACAGATGATG GACCCTGGTT ATCCCAAACT GATTACCAAG 1260

AACTTCCAAG GAATCGGGCC TAAAATTGAT GCAGTCTTCT ACTCTAAAAA CAAATACTAC 1320

TATTTCTTCC AAGGATCTAA CCAATTTGAA TATGACTTCC TACTCCAACG TATCACCAAA 1380 AGACTGAAAA GCAATAGCTG GTTTGGTTGT TGA

80

Seq ID NO: 525 Protein sequence Protein Accession ft: P39900

__ 1 11 21 31 41 51

85 i i i i i i

MKFLLILLLQ ATASGALPLN SSTSLEKNNV LFGERYLEKF YGLEINKLPV TKMKYSGNLM 60 KEKIQEMQHF LGLKVTGQLD TSTLEMMHAP RCGVPDVHHF REMPGGPVWR KHYITYRINN 120 YTPDMNREDV DYAIRKAFQV WSNVTPLKFS KINTGMADIL FARGAHGD FHAFDGKGGI 180

LAHAFGPGSG IGGDAHFDED EFWTTHSGGT NLFLTAVHEI GHSLGLGHSS DPKAVMFPTY 240

KYVDINTFRL SADDIRGIQS LYGDPKENQR LPNPDNSEPA LCDPNLSFDA VTTVGNKIFF 300

FKDRFFWLKV SERPKTSVNL ISSLWPTLPS GIEAAYEIEA RNQVFLFKDD KYWLISNLRP 360 EPNYPKSIHS FGFPNFVKKI DAAVFNPRFY RTYFFVDNQY WRYDERRQMM DPGYPKLITK 420 NFQGIGPKID AVFYSKNKYY YFFQGSNQFE YDFLLQRITK TLKSNSWFGC

Seq ID NO: 526 DNA sequence Nucleic Acid Accession ft: NM_024423.1 Coding sequence: 64..2590

1 11 21 31 41 51

G IGCAGGTCTC GICTCTCGGCA CICCTCCCGGC GICCCGCGTTC TICCTGGCCCT GICCCGGCATC 60

CCGATGGCCG CCGCTGGGCC CCGGCGCTCC GTGCGCGGAG CCGTCTGCCT GCATCTGCTG 120

CTGACCCTCG TGATCTTCAG TCGTGATGGT GAAGCCTGCA AAAAGGTGAT ACTTAATGTA 180

CCTTCTAAAC TAGAGGCAGA CAAAATAATT GGCAGAGTTA ATTTGGAAGA GTGCTTCAGG 240

TCTGCAGACC TCATCCGGTC AAGTGATCCT GATTTCAGAG TTCTAAATGA TGGGTCAGTG 300

TACACAGCCA GGGCTGTTGC GCTGTCTGAT AAGAAAAGAT CATTTACCAT ATGGCTTTCT 360

GACAAAAGGA AACAGACACA GAAAGAGGTT ACTGTGCTGC TAGAACATCA GAAGAAGGTA 420

TCGAAGACAA GACACACTAG AGAAACTGTT CTCAGGCGTG CCAAGAGGAG ATGGGCACCT 480

ATTCCTTGCT CTATGCAAGA GAATTCCTTG GGCCCTTTCC CATTGTTTCT TCAACAAGTT 540

GAATCTGATG CAGCACAGAA CTATACTGTC TTCTACTCAA TAAGTGGACG TGGAGTTGAT 600

AAAGAACCTT TAAATTTGTT TTATATAGAA AGAGACACTG GAAATCTATT TTGCACTCGG 660

CCTGTGGATC GTGAAGAATA TGATGTTTTT GATTTGATTG CTTATGCGTC AACTGCAGAT 720

GGATATTCAG CAGATCTGCC CCTCCCACTA CCCATCAGGG TAGAGGATGA AAATGACAAC 780

CACCCTGTTT TCACAGAAGC AATTTATAAT TTTGAAGTTT TGGAAAGTAG TAGACCTGGT 840

ACTACAGTGG GGGTGGTTTG TGCCACAGAC AGAGATGAAC CGGACACAAT GCATACGCGC 900

CTGAAATACA GCATTTTGCA GCAGACACCA AGGTCACCTG GGCTCTTTTC TGTGCATCCC 960

AGCACAGGCG TAATCACCAC AGTCTCTCAT TATTTGGACA GAGAGGTTGT AGACAAGTAC 1020

TCATTGATAA TGAAAGTACA AGACATGGAT GGCCAGTTTT TTGGATTGAT AGGCACATCA 1080

ACTTGTATCA TAACAGTAAC AGATTCAAAT GATAATGCAC CCACTTTCAG ACAAAATGCT 1140

TATGAAGCAT TTGTAGAGGA AAATGCATTC AATGTGGAAA TCTTACGAAT ACCTATAGAA 1200

GATAAGGATT TAATTAACAC TGCCAATTGG AGAGTCAATT TTACCATTTT AAAGGGAAAT 1260

GAAAATGGAC ATTTCAAAAT CAGCACAGAC AAAGAAACTA ATGAAGGTGT TCTTTCTGTT 1320

GTAAAGCCAC TGAATTATGA AGAAAACCGT CAAGTGAACC TGGAAATTGG AGTAAACAAT 1380

GAAGCGCCAT TTGCTAGAGA TATTCCCAGA GTGACAGCCT TGAACAGAGC CTTGGTTACA 1440

GTTCATGTGA GGGATCTGGA TGAGGGGCCT GAATGCACTC CTGCAGCCCA ATATGTGCGG 1500

ATTAAAGAAA ACTTAGCAGT GGGGTCAAAG ATCAACGGCT ATAAGGCATA TGACCCCGAA 1560

AATAGAAATG GCAATGGTTT AAGGTACAAA AAATTGCATG ATCCTAAAGG TTGGATCACC 1620

ATTGATGAAA TTTCAGGGTC AATCATAACT TCCAAAATCC TGGATAGGGA GGTTGAAACT 1680

CCCAAAAATG AGTTGTATAA TATTACAGTC CTGGCAATAG ACAAAGATGA TAGATCATGT 1740

ACTGGAACAC TTGCTGTGAA CATTGAAGAT GTAAATGATA ATCCACCAGA AATACTTCAA 1800

GAATATGTAG TCATTTGCAA ACCAAAAATβ GGGTATACCG ACATTTTAGC TGTTGATCCT 1860

GATGAACCTG TCCATGGAGC TCCATTTTAT TTCAGTTTGC CCAATACTTC TCCAGAAATC 1920

AGTAGACTGT GGAGCCTCAC CAAAGTTAAT GATACAGCTG CCCGTCTTTC ATATCAGAAA 1980

AATGCTGGAT TTCAAGAATA TACCATTCCT ATTACTGTAA AAGACAGGGC CGGCCAAGCT 2040

GCAACAAAAT TATTGAGAGT TAATCTGTGT GAATGTACTC ATCCAACTCA GTGTCGTGCG 2100

ACTTCAAGGA GTACAGGAGT AATACTTGGA AAATGGGCAA TCCTTGCAAT ATTACTGGGT 2160

ATAGCACTGC TCTTTTCTGT ATTGCTAACT TTAGTATGTG GAGTTTTTGG TGCAACTAAA 2220

GGGAAACGTT TTCCTGAAGA TTTAGCACAG CAAAACTTAA TTATATCAAA CACAGAAGCA 2280

CCTGGAGACG ATAGAGTGTG CTCTGCCAAT GGATTTATGA CCCAAACTAC CAACAACTCT 2340

AGCCAAGGTT TTTGTGGTAC TATGGGATCA GGAATGAAAA ATGGAGGGCA GGAAACCATT 2400

GAAATGATGA AAGGAGGAAA CCAGACCTTG GAATCCTGCC GGGGGGCTGG GCATCATCAT 2460

ACCCTGGACT CCTGCAGGGG AGGACACACG GAGGTGGACA ACTGCAGATA CACTTACTCG 2520

GAGTGGCACA GTTTTACTCA ACCCCGTCTC GGTGAAGAAT CCATTAGAGG ACACACTGGT 2580

TAAAAATTAA ACATAAAAGA AATTGCATCG ATGTAATCAG AATGAAGACC GCATGCCATC 2640

CCAAGATTAT GTCCTCACTT ATAACTATGA GGGAAGAGGA TCTCCAGCTG GTTCTGTGGG 2700

CTGCTGCAGT GAAAAGCAGG AAGAAGATGG CCTTGACTTT TTAAATAATT TGGAACCCAA 2760

ATTTATTACA TTAGCAGAAG CATGCACAAA GAGATAATGT CACAGTGCTA CAATTAGGTC 2820

TTTGTCAGAC ATTCTGGAGG TTTCCAAAAA TAATATTGTA AAGTTCAATT TCAACATGTA 2880

TGTATATGAT GATTTTTTTC TCAATTTTGA ATTATGCTAC TCACCAATTT ATATTTTTAA 2940

AGCCAGTTGT TGCTTATCTT TTCCAAAAAG TGAAAAATGT TAAAACAGAC AACTGGTAAA 3000

TCTCAAACTC CAGCACTGGA ATTAAGGTCT CTAAAGCATC TGCTCTTTTT TTTTTTTACG 3060

GATATTTTAG TAATAAATAT GCTGGATAAA TATTAGTCCA ACAATAGCTA AGTTATGCTA 3120

ATATCACATT ATTATGTATT CACTTTAAGT GATAGTTTAA AAAATAAACA AGAAATATTG 3180

AGTATCACTA TGTGAAGAAA GTTTTGGAAA AGAAACAATG AAGACTGAAT TAAATTAAAA 3240

ATGTTGCAGC TCATAAAGAA TTGGGACTCA CCCCTACTGC ACTACCAAAT TCATTTGACT 3300

TTGGAGGCAA AATGTGTTGA AGTGCCCTAT GAAGTAGCAA TTTTCTATAG GAATATAGTT 3360

GGAAATAAAT GTGTGTGTGT ATATTATTAT TAATCAATGC AATATTTAAA ATGAAATGAG 3420

AACAAAGAGG AAAATGGTAA AAACTTGAAA TGAGGCTGGG GTATAGTTTG TCCTACAATA 3480

GAAAAAAGAG AGAGCTTCCT AGGCCTGGGC TCTTAAATGC TGCATTATAA CTGAGTCTAT 3540

GAGGAAATAG TTCCTGTCCA ATTTGTGTAA TTTGTTTAAA ATTGTAAATA AATTAAACTT 3600

TTCTGGTTTC TGTGGGAAGG AAATAGGGAA TCCAATGGAA CAGTAGCTTT GCTTTGCAGT 3660

CTGTTTCAAG ATTTCTGCAT CCACAAGTTA GTAGCAAACT GGGGAATACT CGCTGCAGCT 3720

GGGGTTCCCT GCTTTTTGGT AGCAAGGGTC CAGAGATGAG GTGTTTTTTT CGGGGAGCTA 3780

ATAACAAAAA CATTTTAAAA CTTACCTTTA CTGAAGTTAA ATCCTCTATT GCTGTTTCTA 3840

TTCTCTCTTA TAGTGACCAA CATCTTTTTA ATTTAGATCC AAATAACCAT GTCCTCCTAG 3900

AGTTTAGAGG CTAGAGGGAG CTGAGGGGAG GATCTTACTG AAAGCACCCT GGGGAGATTG 3960

ATTGTCCTTA AACCTAAGCC CCACAAACTT GACACCTGAT CAGGTCTGGG AGCTACAAAA 4020

TTTCATTTTT CTCCTCACTG CCCTTCTTCT GAGTGGCATT GGCCTGAATC AAGGAAAGCC 4080

AGGCCTTGTG GGCCCCCTTC TTTCGGCTTT CTGCTAAAGC AACACCTCCA GCAGAGATTC 4140

CCTTAAGTGA CTCCAGGTTT TCCACCATCC TTCAGCGTGA ATTAATTTTT AATCAGTTTG 4200

CTTTCTCCAG AGAAATTTTA AAATAATAGA AGAAATAGAA ATTTTGAATG TATAAAAGAA 4260

AAAGATCAAG TTGTCATTTT AGAACAGAGG GAACTTTGGG AGAAAGCAGC CCAAGTAGGT 4320

TATTTGTACA GTCAGAGGGC AACAGGAAGA TGCAGGCCTT CAAGGGCAAG GAGAGGCCAC 4380

AAGGAATATG GGTGGGAGTA AAAGCAACAT CGTCTGCTTC ATACTTTTTC CTAGGCTTGG 4440 CACTGCCTTT TCCTTTCTCA GGCCAATGGC AACTGCCATT TGAGTCCGGT GAGGGATCAG 4500

CCAACCTCTT CTCTATGGCT CACCTTATTT GGAGTGAGAA ATCAAGGAGA CAGAGCTGAC 4560

TGCATGATGA GTCTGAAGGC ATTTGCAGGA TGAGCCTGAA CTGGTTGTGC AGAACAAACA 4620

AGGCATTCAT GGGAATTGTT GTATTCCTTC TGCAGCCCTC CTTCTGGGCA CTAAGAAGGT 4680

CTATGAATTA AATGCCTATC TAAAATTCTG ATTTATTCCT ACATTTTCTG TTTTCTAATT 4740

TGACCCTAAA ATCTATGTGT TTTAGACTTA GACTTTTTAT TGCCCCCCCC CCCTTTTTTT 4800

TTGAGACGGA GTCTCGCTCT GACGCACAGG CTGGAGTGCA GTGGCTCCGA TCTCTGCTCA 4860

CTGAAAGCTC CGCCTCCCGG GTTCATGCCA TTCTCCTGCC TCAGCCTCCT GAGTAGCTGG 4920

GACTAGAGGC GCCCACCACC ACGCCCGGCT AATTTTTTGT ATTTTTAATA GAGACGGGGT 4980

TTCACTGTGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC GTGATCCGCC TGCCTCGGCC 5040

TCCCAAAGTG CTGGGATTAC AGGCATGACC CACCGCTCCC GGCCTTGTTT TCCGTTTAAA 5100

GTCGTCTTCT TTTAATGTAA TCATTTTGAA CATGTGTGAA AGTTGATCAT ACGAATTGGA 5160

TCAATCTTGA AATACTCAAC CAAAAGACAG TCGAGAAGCC AGGGGGAGAA AGAACTCAGG 5220

GCACAAAATA TTGGTCTGAG AATGGAATTC TCTGTAAGCC TAGTTGCTGA AATTTCCTGC 5280

TGTAACCAGA AGCCAGTTTT ATCTAACGGC TACTGAAACA CCCACTGTGT TTTGCTCACT 5340

CCCACTCACC GATCAAAACC TGCTACCTCC CCAAGACTTT ACTAGTGCCG ATAAACTTTC 5400

TCAAAGAGCA ACCAGTATCA CTTCCCTGTT TATAAAACCT CTAACCATCT CTTTGTTCTT 5460

TGAACATGCT GAAAACCACC TGGTCTGCAT GTATGCCCGA ATTTGTAATT CTTTTCTCTC 5520

AAATGAAAAT TTAATTTTAG GGATTCATTT CTATATTTTC ACATATGTAG TATTATTATT 5580

TCCTTATATG TGTAAGGTGA AATTTATGGT ATTTGAGTGT GCAAGAAAAT ATATTTTTAA 5640

AGCTTTCATT TTTCCCCCAG TGAATGATTT AGAATTTTTT ATGTAAATAT ACAGAATGTT 5700

TTTTCTTACT TTTATAAGGA AGCAGCTGTC TAAAATGCAG TGGGGTTTGT TTTGCAATGT 5760

TTTAAACAGA GTTTTAGTAT TGCTATTAAA AGAAGTTACT TTGCTTTTAA AGAAACTTGG 5820

CTGCTTAAAA TAAGCAAAAA TTGGATGCAT AAAGTAATAT TTACAGATGT GGGGAGATGT 5880

AATAAAACAA TATTAACTTG GCTGCTTAAA ATAAGCAAAA ATTGGATGCA TAAAGTAATA 5940

TTTACAGATG TGGGGAGATG TAATAAAACA ATATTAACTT GGTTTCTTGT TTTTGCTGTA 6000

TTTAGAGATT -AAATAATTCT AAGATGATCA CTTTGCAAAA TTATGCTTAT GGCTGGCATG 6060

GAAATAGAAA TACTCAATTA TGTCTTTGTT GTATTAATGG GGAATATTTT GGACAATGTT 6120

TCATTATCAA ATTGTCGACA TCATTAATAT ATATTGTAAT GTTGGGAAGA GATCACTATT 6180

TTGAAGCACA GCTTTACAGA TGAGTATCTA TGATACATAT GTATAATAAA TTTTGATCGG 6240

GTATTAAAAG TATTAGAAGG TGGTTATAAT TGCAGAGTAT TCCATGAATA GTACACTGAC 6300

ACAGGGGTTT TACTTTGAGG ACCAGTGTAG TCAAGGGAAA ACATGAGTTA AAAAGAAAAG 6360

CAGGCAATAT TGCAGTCTTG ATTCTGCCAC TTACAGGATA GATAATGCCT GAACTTTAAT 6420

GACAAGATGA TCCAACCATA AAGGTGCTCT GTGCTTCACA GTGAATCTTT TCCCCATGCA 6480

GGAGTGTGCT CCCCTACAAA CGTTAAGACT GATCATTTCA AAAATCTATT AGCTATATCA 6540

AAAGCCTTAC ATTTTAATAT AGGTTGAACC AAAATTTCAA TTCCAGTAAC TTCTATTGTA 6600

ACCATTATTT TTGTGTATGT CTTCAAGAAT GTTCATTGGA TTTTTGTTTG TAATAGTAAA 6660

ATACCGGATA CATTTCACGT GTCCTTCAGT ATTGATTTGG TTGAATATTG GGTCATAATG 6720

GTTGAGAAGC ATGGACACTA GAGCCAGAAT GCTTGGATAT GAATCCTGGA TCTGTCACTT 6780

ACTTCTGTGT GACCTTTGAA AGGCTACTTA TTTCCTCTCT TAGCTTTCTC ATTAAAATCA 6840

ATGAACAATG CCAGCCTCAT GGGGTTGTTG AATGATTAAA TTAGTTAATA TACCTAAAGT 6900

ACATAGAACA CTGCCTGCAC ATAGTAAAAG AATTATAAGT GTGAGGTAGT TGGTAAAATT 6960

ATGTAGTTGG ATATACTACC GAACAATATC TAATCTCTTT TTAGGGAAAT AAAGTTTGTG 7020 CATATATATA ATCCCGAAAC ATG

Seq ID NO: 527 Protein sequence Protein Accession ft: NP_077741.1

1 11 21 31 41 51 i i i i i i

MAAAGPRRSV RGAVCLHLLL TLVIFSRDGE ACKKVILNVP SKLEADKIIG RVNLEECFRS 60

ADLIRSSDPD FRVLNDGSVY TARAVALSDK KRSFTIWLSD KRKQTQKEVT VLLEHQKKVS 120

KTRHTRETVL RRAKRRWAPI PCSMQENSLG PFPLFLQQVE SDAAQNYTVF YSISGRGVDK 180

EPLNLFYIER DTGNLFCTRP VDREEYDVFD LIAYASTADG YSADLPLPLP IRVEDENDNH 240 PVFTEAIYNF EVLESSRPGT TVGWCATDR DEPDTMHTRL KYSILQQTPR SPGLFSVHPS 300

TGVITTVSHY LDREWDKYS LIMKVQDMDG QFFGLIGTST CIITVTDSND NAPTFRQNAY 360

EAFVEENAFN VEILRIPIED KDLINTANWR VNFTILKGNE NGHFKISTDK ETNEGVLSW 420

KPLNYEENRQ VNLEIGVNNE APFARDIPRV TALNRALVTV HVRDLDEGPE CTPAAQYVRI 480

KENLAVGSKI NGYKAYDPEN RNGNGLRYKK LHDPKGWITI DEISGSIITS KILDREVETP 540 KNELYNITVL AIDKDDRSCT GTLAVNIEDV NDNPPEILQE YWICKPKMG YTDILAVDPD 600

EPVHGAPFYF SLPNTSPEIS RLWSLTKVND TAARLSYQKN AGFQEYTIPI TVKDRAGQAA 660

TKLLRVNLCE CTHPTQCRAT SRSTGVILGK WAILAILLGI ALLFSVLLTL VCGVFGATKG 720

KRFPEDLAQQ NLIISNTEAP GDDRVCSANG FMTQTTNNSS QGFCGTMGSG MKNGGQETIE 780

MMKGGNQTLE SCRGAGHHHT LDSCRGGHTE VDNCRYTYSE WHSFTQPRLG EESIRGHTG

Seq ID NO: 528 DNA sequence

Nucleic Acid Accession ft: NM_001941.2

Coding sequence: 64..2754

1 11 21 31 41 51

I I I I I I

GGCAGGTCTC GCTCTCGGCA CCCTCCCGGC GCCCGCGTTC TCCTGGCCCT GCCCGGCATC 60

CCGATGGCCG CCGCTGGGCC CCGGCGCTCC GTGCGCGGAG CCGTCTGCCT GCATCTGCTG 120

CTGACCCTCG TGATCTTCAG TCGTGATGGT GAAGCCTGCA AAAAGGTGAT ACTTAATGTA 180

CCTTCTAAAC TAGAGGCAGA CAAAATAATT GGCAGAGTTA ATTTGGAAGA GTGCTTCAGG 240

TCTGCAGACC TCATCCGGTC AAGTGATCCT GATTTCAGAG TTCTAAATGA TGGGTCAGTG 300

TACACAGCCA GGGCTGTTGC GCTGTCTGAT AAGAAAAGAT CATTTACCAT ATGGCTTTCT 360

GACAAAAGGA AACAGACACA GAAAGAGGTT ACTGTGCTGC TAGAACATCA GAAGAAGGTA 420

TCGAAGACAA GACACACTAG AGAAACTGTT CTCAGGCGTG CCAAGAGGAG ATGGGCACCT 480

ATTCCTTGCT CTATGCAAGA GAATTCCTTG GGCCCTTTCC CATTGTTTCT TCAACAAGTT 540

GAATCTGATG CAGCACAGAA CTATACTGTC TTCTACTCAA TAAGTGGACG TGGAGTTGAT 600

AAAGAACCTT TAAATTTGTT TTATATAGAA AGAGACACTG GAAATCTATT TTGCACTCGG 660

CCTGTGGATC GTGAAGAATA TGATGTTTTT GATTTGATTG CTTATGCGTC AACTGCAGAT 720

GGATATTCAG CAGATCTGCC CCTCCCACTA CCCATCAGGG TAGAGGATGA AAATGACAAC 780

CACCCTGTTT TCACAGAAGC AATTTATAAT TTTGAAGTTT TGGAAAGTAG TAGACCTGGT 840

ACTACAGTGG GGGTGGTTTG TGCCACAGAC AGAGATGAAC CGGACACAAT GCATACGCGC 900

CTGAAATACA GCATTTTGCA GCAGACACCA AGGTCACCTG GGCTCTTTTC TGTGCATCCC 960 AGCACAGGCG TAATCACCAC AGTCTCTCAT TATTTGGACA GAGAGGTTGT AGACAAGTAC 1020

TCATTGATAA TGAAAGTACA AGACATGGAT GGCCAGTTTT TTGGATTGAT AGGCACATCA 1080

ACTTGTATCA TAACAGTAAC AGATTCAAAT GATAATGCAC CCACTTTCAG ACAAAATGCT 1140

TATGAAGCAT TTGTAGAGGA AAATGCATTC AATGTGGAAA TCTTACGAAT ACCTATAGAA 1200

GATAAGGATT TAATTAACAC TGCCAATTGG AGAGTCAATT TTACCATTTT AAAGGGAAAT 1260

GAAAATGGAC ATTTCAAAAT CAGCACAGAC AAAGAAACTA ATGAAGGTGT TCTTTCTGTT 1320

GTAAAGCCAC TGAATTATGA AGAAAACCGT CAAGTGAACC TGGAAATTGG AGTAAACAAT 1380

GAAGCGCCAT TTGCTAGAGA TATTCCCAGA GTGACAGCCT TGAACAGAGC CTTGGTTACA 1440

GTTCATGTGA GGGATCTGGA TGAGGGGCCT GAATGCACTC CTGCAGCCCA ATATGTGCGG 1500

ATTAAAGAAA ACTTAGCAGT GGGGTCAAAG ATCAACGGCT ATAAGGCATA TGACCCCGAA 1560

AATAGAAATG GCAATGGTTT AAGGTACAAA AAATTGCATG ATCCTAAAGG TTGGATCACC 1620

ATTGATGAAA TTTCAGGGTC AATCATAACT TCCAAAATCC TGGATAGGGA GGTTGAAACT 1680

CCCAAAAATG AGTTGTATAA TATTACAGTC CTGGCAATAG ACAAAGATGA TAGATCATGT 1740

ACTGGAACAC TTGCTGTGAA CATTGAAGAT GTAAATGATA ATCCACCAGA AATACTTCAA 1800

GAATATGTAG TCATTTGCAA ACCAAAAATG GGGTATACCG ACATTTTAGC TGTTGATCCT 1860

GATGAACCTG TCCATGGAGC TCCATTTTAT TTCAGTTTGC CCAATACTTC TCCAGAAATC 1920

AGTAGACTGT GGAGCCTCAC CAAAGTTAAT GATACAGCTG CCCGTCTTTC ATATCAGAAA 1980

AATGCTGGAT TTCAAGAATA TACCATTCCT ATTACTGTAA AAGACAGGGC CGGCCAAGCT 2040

GCAACAAAAT TATTGAGAGT TAATCTGTGT GAATGTACTC ATCCAACTCA GTGTCGTGCG 2100

ACTTCAAGGA GTACAGGAGT AATACTTGGA AAATGGGCAA TCCTTGCAAT ATTACTGGGT 2160

ATAGCACTGC TCTTTTCTGT ATTGCTAACT TTAGTATGTG GAGTTTTTGG TGCAACTAAA 2220

GGGAAACGTT TTCCTGAAGA TTTAGCACAG CAAAACTTAA TTATATCAAA CACAGAAGCA 2280

CCTGGAGACG ATAGAGTGTG CTCTGCCAAT GGATTTATGA CCCAAACTAC CAACAACTCT 2340

AGCCAAGGTT TTTGTGGTAC TATGGGATCA GGAATGAAAA ATGGAGGGCA GGAAACCATT 2400

GAAATGATGA AAGGAGGAAA CCAGACCTTG GAATCCTGCC GGGGGGCTGG GCATCATCAT 2460

ACCCTGGACT CCTGCAGGGG AGGACACACG GAGGTGGACA ACTGCAGATA CACTTACTCG 2520

GAGTGGCACA GTTTTACTCA ACCCCGTCTC GGTGAAAAAT TGCATCGATG TAATCAGAAT 2580

GAAGACCGCA TGCCATCCCA AGATTATGTC CTCACTTATA ACTATGAGGG AAGAGGATCT 2640

CCAGCTGGTT CTGTGGGCTG CTGCAGTGAA AAGCAGGAAG AAGATGGCCT TGACTTTTTA 2700

AATAATTTGG AACCCAAATT TATTACATTA GCAGAAGCAT GCACAAAGAG ATAATGTCAC 2760

AGTGCTACAA TTAGGTCTTT GTCAGACATT CTGGAGGTTT CCAAAAATAA TATTGTAAAG 2820

TTCAATTTCA ACATGTATGT ATATGATGAT TTTTTTCTCA ATTTTGAATT ATGCTACTCA 2880

CCAATTTATA TTTTTAAAGC CAGTTGTTGC TTATCTTTTC CAAAAAGTGA AAAATGTTAA 2940

AACAGACAAC TGGTAAATCT CAAACTCCAG CACTGGAATT AAGGTCTCTA AAGCATCTGC 3000 TCTTTTTTTT TTTTACGGAT ATTTTAGTAA TAAATATGCT GGATAAATAT TAGTCCAACA 3060

ATAGCTAAGT TATGCTAATA TCACATTATT ATGTATTCAC TTTAAGTGAT AGTTTAAAAA 3120

ATAAACAAGA AATATTGAGT ATCACTATGT GAAGAAAGTT TTGGAAAAGA AACAATGAAG 3180

ACTGAATTAA ATTAAAAATG TTGCAGCTCA TAAAGAATTG GGACTCACCC CTACTGCACT 3240

ACCAAATTCA TTTGACTTTG GAGGCAAAAT GTGTTGAAGT GCCCTATGAA GTAGCAATTT 3300

TCTATAGGAA TATAGTTGGA AATAAATGTG TGTGTGTATA TTATTATTAA TCAATGCAAT 3360

ATTTAAAATG AAATGAGAAC AAAGAGGAAA ATGGTAAAAA CTTGAAATGA GGCTGGGGTA 3420

TAGTTTGTCC TACAATAGAA AAAAGAGAGA GCTTCCTAGG CCTGGGCTCT TAAATGCTGC 3480

ATTATAACTG AGTCTATGAG GAAATAGTTC CTGTCCAATT TGTGTAATTT GTTTAAAATT 3540

GTAAATAAAT TAAACTTTTC TGGTTTCTGT GGGAAGGAAA TAGGGAATCC AATGGAAGAG 3600

TAGCTTTGCT TTGCAGTCTG TTTCAAGATT TCTGCATCCA CAAGTTAGTA GCAAACTGGG 3660

GAATACTCGC TGCAGCTGGG GTTCCCTGCT TTTTGGTAGC AAGGGTCCAG AGATGAGGTG 3720

TTTTTTTCGG GGAGCTAATA ACAAAAACAT TTTAAAACTT ACCTTTACTG AAGTTAAATC 3780

CTCTATTGCT GTTTCTATTC TCTCTTATAG TGACCAACAT CTTTTTAATT TAGATCCAAA 3840

TAACCATGTC CTCCTAGAGT TTAGAGGCTA GAGGGAGCTG AGGGGAGGAT CTTACTGAAA 3900

GCACCCTGGG GAGATTGATT GTCCTTAAAC CTAAGCCCCA CAAACTTGAC ACCTGATCAG 3960

GTCTGGGAGC TACAAAATTT CATTTTTCTC CTCACTGCCC TTCTTCTGAG TGGCATTGGC 4020

CTGAATCAAG GAAAGCCAGG CCTTGTGGGC CCCCTTCTTT CGGCTTTCTG CTAAAGCAAC 4080

ACCTCCAGCA GAGATTCCCT TAAGTGACTC CAGGTTTTCC ACCATCCTTC AGCGTGAATT 4140

AATTTTTAAT CAGTTTGCTT TCTCCAGAGA AATTTTAAAA TAATAGAAGA AATAGAAATT 4200

TTGAATGTAT AAAAGAAAAA GATCAAGTTG TCATTTTAGA ACAGAGGGAA CTTTGGGAGA 4260

AAGCAGCCCA AGTAGGTTAT TTGTACAGTC AGAGGGCAAC AGGAAGATGC AGGCCTTCAA 4320

GGGCAAGGAG AGGCCACAAG GAATATGGGT GGGAGTAAAA GCAACATCGT CTGCTTCATA 4380

CTTTTTCCTA GGCTTGGCAC TGCCTTTTCC TTTCTCAGGC CAATGGCAAC TGCCATTTGA 4440

GTCCGGTGAG GGATCAGCCA ACCTCTTCTC TATGGCTCAC CTTATTTGGA GTGAGAAATC 4500 AAGGAGACAG AGCTGACTGC ATGATGAGTC TGAAGGCATT TGCAGGATGA GCCTGAACTG 4560

GTTGTGCAGA ACAAACAAGG CATTCATGGG AATTGTTGTA TTCCTTCTGC AGCCCTCCTT 4620

CTGGGCACTA AGAAGGTCTA TGAATTAAAT GCCTATCTAA AATTCTGATT TATTCCTACA 4680

TTTTCTGTTT TCTAATTTGA CCCTAAAATC TATGTGTTTT AGACTTAGAC TTTTTATTGC 4740

CCCCCCCCCC TTTTTTTTTG AGACGGAGTC TCGCTCTGAC GCACAGGCTG GAGTGCAGTG 4800

GCTCCGATCT CTGCTCACTG AAAGCTCCGC CTCCCGGGTT CATGCCATTC TCCTGCCTCA 4860

GCCTCCTGAG TAGCTGGGAC TACAGGCGCC CACCACCACG CCCGGCTAAT TTTTTGTATT 4920

TTTAATAGAG ACGGGGTTTC ACTGTGTTAG CCAGGATGGT CTCGATCTCC TGACCTCGTG 4980

ATCCGCCTGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG CATGACCCAC CGCTCCCGGC 5040

CTTGTTTTCC GTTTAAAGTC GTCTTCTTTT AATGTAATCA TTTTGAACAT GTGTGAAAGT 5100

TGATCATACG AATTGGATCA ATCTTGAAAT ACTCAACCAA AAGACAGTCG AGAAGCCAGG 5160

GGGAGAAAGA ACTCAGGGCA CAAAATATTG GTCTGAGAAT GGAATTCTCT GTAAGCCTAG 5220

TTGCTGAAAT TTCCTGCTGT AACCAGAAGC CAGTTTTATC TAACGGCTAC TGAAACACCC 5280

ACTGTGTTTT GCTCACTCCC TCACTCACCG ATCAAAACCT GCTACCTCCC CAAGACTTTA 5340

CTAGTGCCGA TAAACTTTCT CAAAGAGCAA CCAGTATCAC TTCCCTGTTT ATAAAACCTC 5400

TAACCATCTC TTTGTTCTTT GAACATGCTG AAAACCACCT GGTCTGCATG TATGCCCGAA 5460

TTTGTAATTC TTTTCTCTCA AATGAAAATT TAATTTTAGG GATTCATTTC TATATTTTCA 5520

CATATGTAGT ATTATTATTT CCTTATATGT GTAAGGTGAA ATTTATGGTA TTTGAGTGTG 5580

CAAGAAAATA TATTTTTAAA GCTTTCATTT TTCCCCCAGT GAATGATTTA GAATTTTTTA 5640

TGTAAATATA CAGAATGTTT TTTCTTACTT TTATAAGGAA GCAGCTGTCT AAAATGCAGT 5700

GGGGTTTGTT TTGCAATGTT TTAAACAGAG TTTTAGTATT GCTATTAAAA GAAGTTACTT 5760

TGCTTTTAAA GAAACTTGGC TGCTTAAAAT AAGCAAAAAT TGGATGCATA AAGTAATATT 5820

TACAGATGTG GGGAGATGTA ATAAAACAAT ATTAACTTGG TTTCTTGTTT TTGCTGTATT 5880

TAGAGATTAA ATAATTCTAA GATGATCACT TTGCAAAATT ATGCTTATGG CTGGCATGGA 5940

AATAGAAATA CTCAATTATG TCTTTGTTGT ATTAATGGGG AATATTTTGG ACAATGTTTC 6000

ATTATCAAAT TGTCGACATC ATTAATATAT ATTGTAATGT TGGGAAGAGA TCACTATTTT 6060

GAAGCACAGC TTTACAGATG AGTATCTATG ATACATATGT ATAATAAATT TTGATCGGGT 6120

ATTAAAAGTA TTAGAAGGTG GTTATAATTG CAGAGTATTC CATGAATAGT ACACTGACAC 6180 AGGGGTTTTA CTTTGAGGAC CAGTGTAGTC AAGGGAAAAC ATGAGTTAAA AAGAAAAGCA 6240

GGCAATATTG CAGTCTTGAT TCTGCCACTT ACAGGATAGA TAATGCCTGA ACTTTAATGA 6300

CAAGATGATC CAACCATAAA GGTGCTCTGT GCTTCACAGT GAATCTTTTC CCCATGCAGG 6360

AGTGTGCTCC CCTACAAACG TTAAGACTGA TCATTTCAAA AATCTATTAG CTATATCAAA 6420

AGCCTTACAT TTTAATATAG GTTGAACCAA AATTTCAATT CCAGTAACTT CTATTGTAAC 6480

CATTATTTTT GTGTATGTCT TCAAGAATGT TCATTGGATT TTTGTTTGTA ATAGTAAAAT 6540

ACCGGATACA TTTCACGTGT CCTTCAGTAT TGATTTGGTT GAATATTGGG TCATAATGGT 6600

TGAGAAGCAT GGACACTAGA GCCAGAATGC TTGGATATGA ATCCTGGATC TGTCACTTAC 6660

TTCTGTGTGA CCTTTGAAAG GCTACTTATT TCCTCTCTTA GCTTTCTCAT TAAAATCAAT 6720

GAACAATGCC AGCCTCATGG GGTTGTTGAA TGATTAAATT AGTTAATATA CCTAAAGTAC 6780

ATAGAACACT GCCTGCACAT AGTAAAAGAA TTATAAGTGT GAGGTAGTTG GTAAAATTAT 6840

GTAGTTGGAT ATACTACCGA ACAATATCTA ATCTCTTTTT AGGGAAATAA AGTTTGTGCA 6900 TATATATAAT CCCGAAACAT G Seq ID NO: 529 Protein sequence Protein Accession ft: NP 001932.1

1 11 21 31 41 51

I I I I I I

MAAAGPRRSV RGAVCLHLLL TLVIFSRDGE ACKKVILNVP SKLEADKIIG RVNLEECFRS 60

ADLIRSSDPD FRVLNDGSVY TARAVALSDK KRSFTIWLSD KRKQTQKEVT VLLEHQKKVS 120

KTRHTRETVL RRAKRRWAPI PCSMQENSLG PFPLFLQQVE SDAAQNYTVF YSISGRGVDK 180

EPLNLFYIER DTGNLFCTRP VDREEYDVFD LIAYASTADG YSADLPLPLP IRVEDENDNH 240

PVFTEAIYNF EVLESSRPGT TVGWCATDR DEPDTMHTRL KYSILQQTPR SPGLFSVHPS 300

TGVITTVSHY LDREWDKYS LIMKVQDMDG QFFGLIGTST CIITVTDSND NAPTFRQNAY 360

EAFVEENAFN VEILRIPIED KDLINTANWR VNFTILKGNE NGHFKISTDK ETNEGVLSW 420

KPLNYEENRQ VNLEIGVNNE APFARDIPRV TALNRALVTV HVRDLDEGPE CTPAAQYVRI 480

KENLAVGSKI NGYKAYDPEN RNGNGLRYKK LHDPKGWITI DEISGSIITS KILDREVETP 540

KNELYNITVL AIDKDDRSCT GTLAVNIEDV NDNPPEILQE YWICKPKMG YTDILAVDPD 600

EPVHGAPFYF SLPNTSPEIS RLWSLTKVND TAARLSYQKN AGFQEYTIPI TVKDRAGQAA 660

TKLLRVNLCE CTHPTQCRAT SRSTGVILGK WAILAILLGI ALLFSVLLTL VCGVFGATKG 720

KRFPEDLAQQ NLIISNTEAP GDDRVCSANG FMTQTTNNSS QGFCGTMGSG MKNGGQETIE 780

MMKGGNQTLE SCRGAGHHHT LDSCRGGHTE VDNCRYTYSE WHSFTQPRLG EKLHRCNQNE 840 DRMPSQDYVL TYNYEGRGSP AGSVGCCSEK QEEDGLDFLN NLEPKFITLA EACTKR

Seq ID NO: 530 DNA sequence

Nucleic Acid Accession ft: NM_016583.2

Coding sequence : 72..842

1 11 21 31 41 51

I I I I I I

GGAGTGGGGG AGAGAGAGGA GACCAGGACA GCTGCTGAGA CCTCTAAGAA GTCCAGATAC 60

TAAGAGCAAA GATGTTTCAA ACTGGGGGCC TCATTGTCTT CTACGGGCTG TTAGCCCAGA 120

CCATGGCCCA GTTTGGAGGC CTGCCCGTGC CCCTGGACCA GACCCTGCCC TTGAATGTGA 180

ATCCAGCCCT GCCCTTGAGT CCCACAGGTC TTGCAGGAAG CTTGACAAAT GCCCTCAGCA 240

ATGGCCTGCT GTCTGGGGGC CTGTTGGGCA TTCTGGAAAA CCTTCCGCTC CTGGACATCC 300

TGAAGCCTGG AGGAGGTACT TCTGGTGGCC TCCTTGGGGG ACTGCTTGGA AAAGTGACGT 360

CAGTGATTCC TGGCCTGAAC AACATCATTG ACATAAAGGT CACTGACCCC CAGCTGCTGG 420

AACTTGGCCT TGTGCAGAGC CCTGATGGCC ACCGTCTCTA TGTCACCATC CCTCTCGGCA 480

TAAAGCTCCA AGTGAATACG CCCCTGGTCG GTGCAAGTCT GTTGAGGCTG GCTGTGAAGC 540

TGGACATCAC TGCAGAAATC TTAGCTGTGA GAGATAAGCA GGAGAGGATC CACCTGGTCC 600

TTGGTGACTG CACCCATTCC CCTGGAAGCC TGCAAATTTC TCTGCTTGAT GGACTTGGCC 660

CCCTCCCCAT TCAAGGTCTT CTGGACAGCC TCACAGGGAT CTTGAATAAA GTCCTGCCTG 720

AGTTGGTTCA GGGCAACGTG TGCCCTCTGG TCAATGAGGT TCTCAGAGGC TTGGACATCA 780

CCCTGGTGCA TGACATTGTT AACATGCTGA TCCACGGACT ACAGTTTGTC ATCAAGGTCT 840

AAGCCTTCCA GGAAGGGGCT GGCCTCTGCT GAGCTGCTTC CCAGTGCTCA CAGATGGCTG 900

GCCCATGTGC TGGAAGATGA CACAGTTGCC TTCTCTCCGA GGAACCTGCC CCCTCTCCTT 960

TCCCACCAGG CGTGTGTAAC ATCCCATGTG CCTCACCTAA TAAAATGGCT CTTCTTCTGC 1020 AAAAAAAAAA AAAAAAAAAA AAAAAAAAA

Seq ID NO: 531 Protein sequence Protein Accession ft: NP_057667.1

1 11 21 31 41 51

I I I I I I

MFQTGGLIVF YGLLAQTMAQ FGGLPVPLDQ TLPLNVNPAL PLSPTGLAGS LTNALSNGLL 60

SGGLLGILEN LPLLDILKPG GGTSGGLLGG LLGKVTSVIP GLNNIIDIKV TDPQLLELGL 120

VQSPDGHRLY VTIPLGIKLQ VNTPLVGASL LRLAVKLDIT AEILAVRDKQ ERIHLVLGDC 180

THSPGSLQIS LLDGLGPLPI QGLLDSLTGI LNKVLPELVQ GNVCPLVNEV LRGLDITLVH 240 DIVNMLIHGL QFVIKV

Seq ID NO: 532 DNA sequence

Nucleic Acid Accession ft: NM_004363.1

Coding sequence: 115..2223

1 11 21 31 41 51

I I I I I I

CTCAGGGCAG AGGGAGGAAG GACAGCAGAC CAGACAGTCA CAGCAGCCTT GACAAAACGT 60

TCCTGGAACT CAAGCTCTTC TCCACAGAGG AGGACAGAGC AGACAGCAGA GACCATGGAG 120

TCTCCCTCGG CCCCTCCCCA CAGATGGTGC ATCCCCTGGC AGAGGCTCCT GCTCACAGCC 180

TCACTTCTAA CCTTCTGGAA CCCGCCCACC ACTGCCAAGC TCACTATTGA ATCCACGCCG 240

TTCAATGTCG CAGAGGGGAA GGAGGTGCTT CTACTTGTCC ACAATCTGCC CCAGCATCTT 300

TTTGGCTACA GCTGGTACAA AGGTGAAAGA GTGGATGGCA ACCGTCAAAT TATAGGATAT 360

GTAATAGGAA CTCAACAAGC TACCCCAGGG CCCGCATACA GTGGTCGAGA GATAATATAC 420

CCCAATGCAT CCCTGCTGAT CCAGAACATC ATCCAGAATG ACACAGGATT CTACACCCTA 480 CACGTCATAA AGTCAGATCT TGTGAATGAA GAAGCAACTG GCCAGTTCCG GGTATACCCG 540 GAGCTGCCCA AGCCCTCCAT CTCCAGCAAC AACTCCAAAC CCGTGGAGGA CAAGGATGCT 600 GTGGCCTTCA CCTGTGAACC TGAGACTCAG GACGCAACCT ACCTGTGGTG GGTAAACAAT 660 CAGAGCCTCC CGGTCAGTCC CAGGCTGCAG CTGTCCAATG GCAACAGGAC CCTCACTCTA 720 TTCAATGTCA CAAGAAATGA CACAGCAAGC TACAAATGTG AAACCCAGAA CCCAGTGAGT 780 GCCAGGCGCA GTGATTCAGT CATCCTGAAT GTCCTCTATG GCCCGGATGC CCCCACCATT 840 TCCCCTCTAA ACACATCTTA CAGATCAGGG GAAAATCTGA ACCTCTCCTG CCACGCAGCC 900 TCTAACCCAC CTGCACAGTA CTCTTGGTTT GTCAATGGGA CTTTCCAGCA ATCCACCCAA 960 GAGCTCTTTA TCCCCAACAT CACTGTGAAT AATAGTGGAT CCTATACGTG CCAAGCCCAT 1020 AACTCAGACA CTGGCCTCAA TAGGACCACA GTCACGACGA TCACAGTCTA TGCAGAGCCA 1080 CCCAAACCCT TCATCACCAG CAACAACTCC AACCCCGTGG AGGATGAGGA TGCTGTAGCC 1140 TTAACCTGTG AACCTGAGAT TCAGAACACA ACCTACCTGT GGTGGGTAAA TAATCAGAGC 1200 CTCCCGGTCA GTCCCAGGCT GCAGCTGTCC AATGACAACA GGACCCTCAC TCTACTCAGT 1260 GTCACAAGGA ATGATGTAGG ACCCTATGAG TGTGGAATCC AGAACGAATT AAGTGTTGAC 1320 CACAGCGACC CAGTCATCCT GAATGTCCTC TATGGCCCAG ACGACCCCAC CATTTCCCCC 1380 TCATACACCT ATTACCGTCC AGG_rGGTGAAC CTCAGCCTCT CCTGCCATGC AGCCTCTAAC 1440 CCACCTGCAC AGTATTCTTG GCTGATTGAT GGGAACATCC AGCAACACAC ACAAGAGCTC 1500 TTTATCTCCA ACATCACTGA GAAGAACAGC GGACTCTATA CCTGCCAGGC CAATAACTCA 1560 GCCAGTGGCC ACAGCAGGAC TACAGTCAAG ACAATCACAG TCTCTGCGGA GCTGCCCAAG 1620 CCCTCCATCT CCAGCAACAA CTCCAAACCC GTGGAGGACA AGGATGCTGT GGCCTTCACC 1680 TGTGAACCTG AGGCTCAGAA CACAACCTAC CTGTGGTGGG TAAATGGTCA GAGCCTCCCA 1740 GTCAGTCCCA GGCTGCAGCT GTCCAATGGC AACAGGACCC TCACTCTATT CAATGTCACA 1800 AGAAATGACG CAAGAGCCTA TGTATGTGGA ATCCAGAACT CAGTGAGTGC AAACCGCAGT 1860 GACCCAGTCA CCCTGGATGT CCTCTATGGG CCGGACACCC CCATCATTTC GCCCCCAGAC 1920 TCGTCTTACC TTTCGGGAGC GAACCTCAAC CTCTCCTGCC ACTCGGCCTC TAACCCATCC 1980 CCGCAGTATT CTTGGCGTAT CAATGGGATA CCGCAGCAAC ACACACAAGT TCTCTTTATC 2040 GCCAAAATCA CGCCAAATAA TAACGGGACC TATGCCTGTT TTGTCTCTAA CTTGGCTACT 2100 GGCCGCAATA ATTCCATAGT CAAGAGCATC ACAGTCTCTG CATCTGGAAC TTCTCCTGGT 2160 CTCTCAGCTG GGGCCACTGT CGGCATCATG ATTGGAGTGC TGGTTGGGGT TGCTCTGATA 2220 TAGCAGCCCT GGTGTAGTTT CTTCATTTCA GGAAGACTGA CAGTTGTTTT GCTTCTTCCT 2280 TAAAGCATTT GCAACAGCTA CAGTCTAAAA TTGCTTCTTT ACCAAGGATA TTTACAGAAA 2340 AGACTCTGAC CAGAGATCGA GACCATCCTA GCCAACATCG TGAAACCCCA TCTCTACTAA 2400 AAATACAAAA ATGAGCTGGG CTTGGTGGCG CGCACCTGTA GTCCCAGTTA CTCGGGAGGC 2460 TGAGGCAGGA GAATCGCTTG AACCCGGGAG GTGGAGATTG CAGTGAGCCC AGATCGCACC 2520 ACTGCACTCC AGTCTGGCAA CAGAGCAAGA CTCCATCTCA AAAAGAAAAG AAAAGAAGAC 2580 TCTGACCTGT ACTCTTGAAT ACAAGTTTCT GATACCACTG CACTGTCTGA GAATTTCCAA 2640 AACTTTAATG AACTAACTGA CAGCTTCATG AAACTGTCCA CCAAGATCAA GCAGAGAAAA 2700 TAATTAATTT CATGGGACTA AATGAACTAA TGAGGATTGC TGATTCTTTA AATGTCTTGT 2760 TTCCCAGATT TCAGGAAACT TTTTTTCTTT TAAGCTATCC ACTCTTACAG CAATTTGATA 2820 AAATATACTT TTGTGAACAA AAATTGAGAC ATTTACATTT TCTCCCTATG TGGTCGCTCC 2880 AGACTTGGGA AACTATTCAT GAATATTTAT ATTGTATGGT AATATAGTTA TTGCACAAGT 2940 TCAATAAAAA TCTGCTCTTT GTATAACAGA AAAA

Seq ID NO: 533 Protein sequence Protein Accession ft: NP 004354.1

21 31 51

MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE VLLLVHNLPQ 60

HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI IYPNASLLIQ NIIQNDTGFY 120

TLHVIKSDLV NEEATGQFRV YPELPKPSIS SNNSKPVEDK DAVAFTCEPE TQDATYLWWV 180

NNQSLPVSPR LQLSNGNRTL TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP 240

TISPLNTSYR SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ 300

AHNSDTGLNR TTVTTITVYA EPPKPFITSN NSNPVEDEDA VALTCEPEIQ NTTYLWWVNN 360

QSLPVSPRLQ LSNDNRTLTL LSVTRNDVGP YECGIQNELS VDHSDPVILN VLYGPDDPTI 420

SPSYTYYRPG VNLSLSCHAA SNPPAQYSWL IDGNIQQHTQ ELFISNITEK NSGLYTCQAN 480

NSASGHSRTT VKTITVSAEL PKPSISSNNS KPVEDKDAVA FTCEPEAQNT TYLWWVNGQS 540

LPVSPRLQLS NGNRTLTLFN VTRNDARAYV CGIQNSVSAN RSDPVTLDVL YGPDTPIISP 600

PDSSYLSGAN LNLSCHSASN PSPQYSWRIN GIPQQHTQVL FIAKITPNNN GTYACFVSNL 660

ATGRNNSIVK SITVSASGTS PGLSAGATVG IMIGVLVGVA LI

Seq ID NO: 534 DNA sequence

Nucleic Acid Accession ft: NM_006952.1

Coding sequence: 11..793

11 21 31

AATCCCGACA ATGGCGAAAG ACAACTCAAC TGTTCGTTGC TTCCAGGGCC TGCTGATTTT 60

TGGAAATGTG ATTATTGGTT GTTGCGGCAT TGCCCTGACT GCGGAGTGCA TCTTCTTTGT 120

ATCTGACCAA CACAGCCTCT ACCCACTGCT TGAAGCCACC GACAACGATG ACATCTATGG 180

GGCTGCCTGG ATCGGCATAT TTGTGGGCAT CTGCCTCTTC TGCCTGTCTG TTCTAGGCAT 240

TGTAGGCATC ATGAAGTCCA GCAGGAAAAT TCTTCTGGCG TATTTCATTC TGATGTTTAT 300

AGTATATGCC TTTGAAGTGG CATCTTGTAT CACAGCAGCA ACACAACGAG ACTTTTTCAC 360

ACCCAACCTC TTCCTGAAGC AGATGCTAGA GAGGTACCAA AACAACAGCC CTCCAAACAA 420

TGATGACCAG TGGAAAAACA ATGGAGTCAC CAAAACCTGG GACAGGCTCA TGCTCCAGGA 480

CAATTGCTGT GGCGTAAATG GTCCATCAGA CTGGCAAAAA TACACATCTG CCTTCCGGAC 540

TGAGAATAAT GATGCTGACT ATCCCTGGCC TCGTCAATGC TGTGTTATGA ACAATCTTAA 600

AGAACCTCTC AACCTGGAGG CTTGTAAACT AGGCGTGCCT GGTTTTTATC ACAATCAGGG 660

CTGCTATGAA CTGATCTCTG GTCCAATGAA CCGACACGCC TGGGGGGTTG CCTGGTTTGG 720

ATTTGCCATT CTCTGCTGGA CTTTTTGGGT TCTCCTGGGT ACCATGTTCT ACTGGAGCAG 780

AATTGAATAT TAAGAA

Seq ID NO: 535 Protein sequence Protein Accession ft: NP 008883.1

31 MAKDNSTVRC FQGLLIFGNV IIGCCGIALT AECIFFVSDQ HSLYPLLEAT DNDDIYGAAW 60

IGIFVGICLF CLSVLGIVGI MKSSRKILLA YFILMFIVYA FEVASCITAA TQRDFFTPNL 120

FLKQMLERYQ NNSPPNNDDQ WKNNGVTKTW DRLMLQDNCC GVNGPSDWQK YTSAFRTENN 180

DADYPWPRQC CVMNNLKEPL NLEACKLGVP GFYHNQGCYE LISGPMNRHA WGVAWFGFAI 240 LCWTFWVLLG TMFYWSRIEY

Seq ID NO: 536 DNA sequence

Nucleic Acid Accession ft: NM_002638.1

Coding sequence: 120..473

1 11 21 31 41 51

I I I I I I

CAATACAGCT AAGGAATTAT CCCTTGTAAA TACCACAGAC CCGCCCTGGA GCCAGGCCAA 60

GCTGGACTGC ATAAAGATTG GTATGGCCTT AGCTCTTAGC CAAACACCTT CCTGACACCA 120

TGAGGGCCAG CAGCTTCTTG ATCGTGGTGG TGTTCCTCAT CGCTGGGACG CTGGTTCTAG 180

AGGCAGCTGT CACGGGAGTT CCTGTTAAAG GTCAAGACAC TGTCAAAGGC CGTGTTCCAT 240

TCAATGGACA AGATCCCGTT AAAGGACAAG TTTCAGTTAA AGGTCAAGAT AAAGTCAAAG 300

CGCAAGAGCC AGTCAAAGGT CCAGTCTCCA CTAAGCCTGG CTCCTGCCCC ATTATCTTGA 360

TCCGGTGCGC CATGTTGAAT CCCCCTAACC GCTGCTTGAA AGATACTGAC TGCCCAGGAA 420

TCAAGAAGTG CTGTGAAGGC TCTTGCGGGA TGGCCTGTTT CGTTCCCCAG TGAAGGGAGC 480

CGGTCCTTGC TGCACCTGTG CCGTCCCCAG AGCTACAGGC CCCATCTGGT CCTAAGTCCC 540

TGCTGCCCTT CCCCTTCCCA CACTGTCCAT TCTTCCTCCC ATTCAGGATG CCCACGGCTG 600 GAGCTGCCTC TCTCATCCAC TTTCCAATAA A

Seq ID NO: 537 Protein sequence Protein Accession ft: NP_002629.1

1 11 21 31 41 51 ^"

I I 1 I . 1 I

MRASSFLIW VFLIAGTLVL EAAVTGVPVK GQDTVKGRVP FNGQDPVKGQ VSVKGQDKVK 60 AQEPVKGPVS TKPGSCPIIL IRCAMLNPPN RCLKDTDCPG IKKCCEGSCG MACFVPQ

Seq ID NO: 538 DNA sequence

Nucleic Acid Accession ft: NM_001793.2

Coding sequence: 71..2560

1 11 21 31 41 51

I I I I I I

AAAGGGGCAA GAGCTGAGCG GAACACCGGC CCGCCGTCGC GGCAGCTGCT TCACCCCTCT 60

CTCTGCAGCC ATGGGGCTCC CTCGTGGACC TCTCGCGTCT CTCCTCCTTC TCCAGGTTTG 120

CTGGCTGCAG TGCGCGGCCT CCGAGCCGTG CCGGGCGGTC TTCAGGGAGG CTGAAGTGAC 180

CTTGGAGGCG GGAGGCGCGG AGCAGGAGCC CGGCCAGGCG CTGGGGAAAG TATTCATGGG 240

CTGCCCTGGG CAAGAGCCAG CTCTGTTTAG CACTGATAAT GATGACTTCA CTGTGCGGAA 300

TGGCGAGACA GTCCAGGAAA GAAGGTCACT GAAGGAAAGG AATCCATTGA AGATCTTCCC 360

ATCCAAACGT ATCTTACGAA GACACAAGAG AGATTGGGTG GTTGCTCCAA TATCTGTCCC 420

TGAAAATGGC AAGGGTCCCT TCCCCCAGAG ACTGAATCAG CTCAAGTCTA ATAAAGATAG 480

AGACACCAAG ATTTTCTACA GCATCACGGG GCCGGGGGCA GACAGCCCCC CTGAGGGTGT 540

CTTCGCTGTA GAGAAGGAGA CAGGCTGGTT GTTGTTGAAT AAGCCACTGG ACCGGGAGGA 600

GATTGCCAAG TATGAGCTCT TTGGCCACGC TGTGTCAGAG AATGGTGCCT CAGTGGAGGA 660

CCCCATGAAC ATCTCCATCA TCGTGACCGA CCAGAATGAC CACAAGCCCA AGTTTACCCA 720

GGACACCTTC CGAGGGAGTG TCTTAGAGGG AGTCCTACCA GGTACTTCTG TGATGCAGGT 780

GACAGCCACG GATGAGGATG ATGCCATCTA CACCTACAAT GGGGTGGTTG CTTACTCCAT 840

CCATAGCCAA GAACCAAAGG ACCCACACGA CCTCATGTTC ACCATTCACC GGAGCACAGG 900

CACCATCAGC GTCATCTCCA GTGGCCTGGA CCGGGAAAAA GTCCCTGAGT ACACACTGAC 960

CATCCAGGCC ACAGACATGG ATGGGGACGG CTCCACCACC ACGGCAGTGG CAGTAGTGGA 1020

GATCCTTGAT GCCAATGACA ATGCTCCCAT GTTTGACCCC CAGAAGTACG AGGCCCATGT 1080

GCCTGAGAAT GCAGTGGGCC ATGAGGTGCA GAGGCTGACG GTCACTGATC TGGACGCCCC 1140

CAACTCACCA GCGTGGCGTG CCACCTACCT TATCATGGGC GGTGACGACG GGGACCATTT 1200

TACCATCACC ACCCACCCTG AGAGCAACCA GGGCATCCTG ACAACCAGGA AGGGTTTGGA 1260

TTTTGAGGCC AAAAACCAGC ACACCCTGTA CGTTGAAGTG ACCAACGAGG CCCCTTTTGT 1320

GCTGAAGCTC CCAACCTCCA CAGCCACCAT AGTGGTCCAC GTGGAGGATG TGAATGAGGC 1380

ACCTGTGTTT GTCCCACCCT CCAAAGTCGT TGAGGTCCAG GAGGGCATCC CCACTGGGGA 1440

GCCTGTGTGT GTCTACACTG CAGAAGACCC TGACAAGGAG AATCAAAAGA TCAGCTACCG 1500

CATCCTGAGA GACCCAGCAG GGTGGCTAGC CATGGACCCA GACAGTGGGC AGGTCACAGC 1560

TGTGGGCACC CTCGACCGTG AGGATGAGCA GTTTGTGAGG AACAACATCT ATGAAGTCAT 1620

GGTCTTGGCC ATGGACAATG GAAGCCCTCC CACCACTGGC ACGGGAACCC TTCTGCTAAC 1680

ACTGATTGAT GTCAATGACC ATGGCCCAGT CCCTGAGCCC CGTCAGATCA CCATCTGCAA 1740

CCAAAGCCCT GTGCGCCAGG TGCTGAACAT CACGGACAAG GACCTGTCTC CCCACACCTC 1800

CCCTTTCCAG GCCCAGCTCA CAGATGACTC AGACATCTAC TGGACGGCAG AGGTCAACGA 1860

GGAAGGTGAC ACAGTGGTCT TGTCCCTGAA GAAGTTCCTG AAGCAGGATA CATATGACGT 1920

GCACCTTTCT CTGTCTGACC ATGGCAACAA AGAGCAGCTG ACGGTGATCA GGGCCACTGT 1980

GTGCGACTGC CATGGCCATG TCGAAACCTG CCCTGGACCC TGGAAGGGAG GTTTCATCCT 2040

CCCTGTGCTG GGGGCTGTCC TGGCTCTGCT GTTCCTCCTG CTGGTGCTGC TTTTGTTGGT 2100

GAGAAAGAAG CGGAAGATCA AGGAGCCCCT CCTACTCCCA GAAGATGACA CCCGTGACAA 2160

CGTCTTCTAC TATGGCGAAG AGGGGGGTGG CGAAGAGGAC CAGGACTATG ACATCACCCA 2220

GCTCCACCGA GGTCTGGAGG CCAGGCCGGA GGTGGTTCTC CGCAATGACG TGGCACCAAC 2280

CATCATCCCG ACACCCATGT ACCGTCCTCG GCCAGCCAAC CCAGATGAAA TCGGCAACTT 2340

TATAATTGAG AACCTGAAGG CGGCTAACAC AGACCCCACA GCCCCGCCCT ACGACACCCT 2400

CTTGGTGTTC GACTATGAGG GCAGCGGCTC CGACGCCGCG TCCCTGAGCT CCCTCACCTC 2460

CTCGGCCTCC GACCAAGACC AAGATTACGA TTATCTGAAC GAGTGGGGCA GCCGCTTCAA 2520

GAAGCTGGCA GACATGTACG GTGGCGGGGA GGACGACTAG GCGGCCTGCC TGCAGGGCTG 2580

GGGACCAAAC GTCAGGCCAC AGAGCATCTC CAAGGGGTCT CAGTTCCCCC TTCAGCTGAG 2640

GACTTCGGAG CTTGTCAGGA AGTGGCCGTA GCAACTTGGC GGAGACAGGC TATGAGTCTG 2700

ACGTTAGAGT GGTTGCTTCC TTAGCCTTTC AGGATGGAGG AATGTGGGCA GTTTGACTTC 2760

AGCACTGAAA ACCTCTCCAC CTGGGCCAGG GTTGCCTCAG AGGCCAAGTT TCCAGAAGCC 2820

TCTTACCTGC CGTAAAATGC TCAACCCTGT GTCCTGGGCC TGGGCCTGCT GTGACTGACC 2880

TACAGTGGAC TTTCTCTCTG GAATGGAACC TTCTTAGGCC TCCTGGTGCA ACTTAATTTT 2940 TTTTTTTAAT GCTATCTTCA AAACGTTAGA GAAAGTTCTT CAAAAGTGCA GCCCAGAGCT 3000

GCTGGGCCCA CTGGCCGTCC TGCATTTCTG GTTTCCAGAC CCCAATGCCT CCCATTCGGA 3060

TGGATCTCTG CGTTTTTATA CTGAGTGTGC CTAGGTTGCC CCTTATTTTT TATTTTCCCT 3120

GTTGCGTTGC TATAGATGAA GGGTGAGGAC AATCGTGTAT ATGTACTAGA ACTTTTTTAT 3180 TAAAGAAACT TTTCCCAGAA AAAAA

Seq ID NO: 539 Protein sequence Protein Accession ft: NP_001784.2

1 11 21 31 41 51

1 I I I I I

MGLPRGPLAS LLLLQVCWLQ CAASEPCRAV FREAEVTLEA GGAEQEPGQA LGKVFMGCPG 60

QEPALFSTDN DDFTVRNGET VQERRSLKER NPLKIFPSKR ILRRHKRDWV VAPISVPENG 120

KGPFPQRLNQ LKSNKDRDTK IFYSITGPGA DSPPEGVFAV EKETGWLLLN KPLDREEIAK 180

YELFGHAVSE NGASVEDPMN ISIIVTDQND HKPKFTQDTF RGSVLEGVLP GTSVMQVTAT 240

DEDDAIYTYN GWAYSIHSQ EPKDPHDLMF TIHRSTGTIS VISSGLDREK VPEYTLTIQA 300

TDMDGDGSTT TAVAWEILD ANDNAPMFDP QKYEAHVPEN AVGHEVQRLT VTDLDAPNSP 360

AWRATYLIMG GDDGDHFTIT THPESNQGIL TTRKGLDFEA KNQHTLYVEV TNEAPFVLKL 420

PTSTATIWH VEDVNEAPVF VPPSKWEVQ EGIPTGEPVC VYTAEDPDKE NQKISYRILR 480

DPAGWLAMDP DSGQVTAVGT LDREDEQFVR NNIYEVMVLA MDNGSPPTTG TGTLLLTLID 540

VNDHGPVPEP RQITICNQSP VRQVLNITDK DLSPHTSPFQ AQLTDDSDIY WTAEVNEEGD 600

TWLSLKKFL KQDTYDVHLS LSDHGNKEQL TVIRATVCDC HGHVETCPGP WKGGFILPVL 660

GAVLALLFLL LVLLLLVRKK RKIKEPLLLP EDDTRDNVFY YGEEGGGEED QDYDITQLHR 720

GLEARPEWL RNDVAPTIIP TPMYRPRPAN PDEIGNFIIE NLKAANTDPT APPYDTLLVF 780 DYEGSGSDAA SLSSLTSSAS DQDQDYDYLN EWGSRFKKLA DMYGGGEDD

Seq ID NO: 540 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 1..672

1 11 21 31 41 51

I I I I I I

ATGAGGCTCC AAAGACCCCG ACAGGCCCCG GCGGGTGGGA GGCGCGCGCC CCGGGGCGGG 60

CGGGGCTCCC CCTACCGGCC AGACCCGGGG AGAGGCGCGC GGAGGCTGCG AAGGTTCCAG 120

AAGGGCGGGG AGGGGGCGCC GCGCGCTGAC CCTCCCTGGG CACCGCTGGG GACGATGGCG 180

CTGCTCGCCT TGCTGCTGGT CGTGGCCCTA CCGCGGGTGT GGACAGACGC GAACCTGACT 240

GCGAGACAAC GAGATCCAGA GGACTCCCAG CGAACGGACG AGGGTGACAA TAGAGTGTGG 300

TGTCATGTTT GTGAGAGAGA AAACACTTTC GAGTGCCAGA ACCCAAGGAG GTGCAAATGG 360

ACAGAGCCAT ACTGCGTTAT AGCGGCCGTG AAAATATTTC CACGTTTTTT CATGGTTGCG 420

AAGCAGTGCT CCGCTGGTTG TGCAGCGATG GAGAGACCCA AGCCAGAGGA GAAGCGGTTT 480

CTCCTGGAAG AGCCCATGCC CTTCTTTTAC CTCAAGTGTT GTAAAATTCG CTACTGCAAT 540

TTAGAGGGGC CACCTATCAA CTCATCAGTG TTCAAAGAAT ATGCTGGGAG CATGGGTGAG 600

AGCTGTGGTG GGCTGTGGCT GGCCATCCTC CTGCTGCTGG CCTCCATTGC AGCCGGCCTC 660 AGCCTGTCTT GA

Seq ID NO: 541 Protein sequence Protein Accession ft: Eos sequence

1 11 21 31 41 51 i i i i i i

MRLQRPRQAP AGGRRAPRGG RGSPYRPDPG RGARRLRRFQ KGGEGAPRAD PPWAPLGTMA 60

LLALLLWAL PRVWTDANLT ARQRDPEDSQ RTDEGDNRVW CHVCERENTF ECQNPRRCKW 120

TEPYCVIAAV KIFPRFFMVA KQCSAGCAAM ERPKPEEKRF LLEEPMPFFY LKCCKIRYCN 180

LEGPPINSSV FKEYAGSMGE SCGGLWLAIL LLLASIAAGL SLS

Seq ID NO: 542 DNA sequence

Nucleic Acid Accession ft: XM_035292.2

Coding sequence: 53..1576

1 11 21 31 41 51

I I I I I I

GCTCGCTGGG CCGCGGCTCC CGGGTGTCCC AGGCCCGGCC GGTGCGCAGA GCATGGCGGG 60

TGCGGGCCCG AAGCGGCGCG CGCTAGCGGC GCCGGCGGCC GAGGAGAAGG AAGAGGCGCG 120

GGAGAAGATG CTGGCCGCCA AGAGCGCGGA CGGCTCGGCG CCGGCAGGCG AGGGCGAGGG 180

CGTGACCCTG CAGCGGAACA TCACGCTGCT CAACGGCGTG GCCATCATCG TGGGGACCAT 240

TATCGGCTCG GGCATCTTCG TGACGCCCAC GGGCGTGCTC AAGGAGGCAG GCTCGCCGGG 300

GCTGGCGCTG GTGGTGTGGG CCGCGTGCGG CGTCTTCTCC ATCGTGGGCG CGCTCTGCTA 360

CGCGGAGCTC GGCACCACCA TCTCCAAATC GGGCGGCGAC TACGCCTACA TGCTGGAGGT 420

CTACGGCTCG CTGCCCGCCT TCCTCAAGCT CTGGATCGAG CTGCTCATCA TCCGGCCTTC 480

ATCGCAGTAC ATCGTGGCCC TGGTCTTCGC CACCTACCTG CTCAAGCCGC TCTTCCCCAC 540

CTGCCCGGTG CCCGAGGAGG CAGCCAAGCT CGTGGCCTGC CTCTGCGTGC TGCTGCTCAC 600

GGCCGTGAAC TGCTACAGCG TGAAGGCCGC CACCCGGGTC CAGGATGCCT TTGCCGCCGC 660

CAAGCTCCTG GCCCTGGCCC TGATCATCCT GCTGGGCTTC GTCCAGATCG GAAAGGGTGA 720

TGTGTCCAAT CTAGATCCCA ACTTCTCATT TGAAGGCACC AAACTGGATG TGGGGAACAT 780

TGTGCTGGCA TTATACAGCG GCCTCTTTGC CTATGGAGGA TGGAATTACT TGAATTTCGT 840

CACAGAGGAA ATGATCAACC CCTACAGAAA CCTGCCCCTG GCCATCATCA TCTCCCTGCC 900

CATCGTGACG CTGGTGTACG TGCTGACCAA CCTGGCCTAC TTCACCACCC TGTCCACCGA 960

GCAGATGCTG TCGTCCGAGG CCGTGGCCGT GGACTTCGGG AACTATCACC TGGGCGTCAT 1020

GTCCTGGATC ATCCCCGTCT TCGTGGGCCT GTCCTGCTTC GGCTCCGTCA ATGGGTCCCT 1080

GTTCACATCC TCCAGGCTCT TCTTCGTGGG GTCCCGGGAA GGCCACCTGC CCTCCATCCT 1140

CTCCATGATC CACCCACAGC TCCTCACCCC CGTGCCGTCC CTCGTGTTCA CGTGTGTGAT 1200

GACGCTGCTC TACGCCTTCT CCAAGGACAT CTTCTCCGTC ATCAACTTCT TCAGCTTCTT 1260

CAACTGGCTC TGCGTGGCCC TGGCCATCAT CGGCATGATC TGGCTGCGCC ACAGAAAGCC 1320

TGAGCTTGAG CGGCCCATCA AGGTGAACCT GGCCCTGCCT GTGTTCTTCA TCCTGGCCTG 1380

CCTCTTCCTG ATCGCCGTCT CCTTCTGGAA GACACCCGTG GAGTGTGGCA TCGGCTTCAC 1440

CATCATCCTC AGCGGGCTGC CCGTCTACTT CTTCGGGGTC TGGTGGAAAA ACAAGCCCAA 1500

GTGGCTCCTC CAGGGCATCT TCTCCACGAC CGTCCTGTGT CAGAAGCTCA TGCAGGTGGT 1560 CCCCCAGGAG ACATAGCCAG GAGGCCGAGT GGCTGCCGGA GGAGCATGC

Seq ID NO: 543 Protein sequence Protein Accession ft: XP 035292.2

MAGAGPKRRA LAAPAAEEKE EAREKMLAAK SADGSAPAGE GEGVTLQRNI TLLNGVAIIV 60

GTIIGSGIFV TPTGVLKEAG SPGLALWWA ACGVFSIVGA LCYAELGTTI SKSGGDYAYM 120

LEVYGSLPAF LKLWIELLII RPSSQYIVAL VFATYLLKPL FPTCPVPEEA AKLVACLCVL 180

LLTAVNCYSV KAATRVQDAF AAAKLLALAL IILLGFVQIG KGDVSNLDPN FSFEGTKLDV 240

GNIVLALYSG LFAYGGWNYL NFVTEEMINP YRNLPLAIII SLPIVTLVYV LTNLAYFTTL 300

STEQMLSSEA VAVDFGNYHL GVMSWIIPVF VGLSCFGSVN GSLFTSSRLF FVGSREGHLP 360

SILSMIHPQL LTPVPSLVFT CVMTLLYAFS KDIFSVINFF SFFNWLCVAL AIIGMIWLRH 420

RKPELERPIK VNLALPVFFI LACLFLIAVS FWKTPVECGI GFTIILSGLP VYFFGVWWKN 480

KPKWLLQGIF STTVLCQKLM QWPQET

Seq ID NO: 544 DNA sequence

Nucleic Acid Accession ft: NM_005268.1

Coding sequence: 168..989

11 21 31 41 51

TAAAAAGCAA AAGAATTCGC GGCCGCGTCG ACACGGGCTT CCCCGAAAAC CTTCCCCGCT 60 TCTGGATATG AAATTCAAGC TGCTTGCTGA GTCCTATTGC CGGCTGCTGG GAGCCAGGAG 120 AGCCCTGAGG AGTAGTCACT CAGTAGCAGC TGACGCGTGG GTCCACCATG AACTGGAGTA 180 TCTTTGAGGG ACTCCTGAGT GGGGTCAACA AGTACTCCAC AGCCTTTGGG CGCATCTGGC 240 TGTCTCTGGT CTTCATCTTC CGCGTGCTGG TGTACCTGGT GACGGCCGAG CGTGTGTGGA 300^" GTGATGACCA CAAGGACTTC GACTGCAATA CTCGCCAGCC CGGCTGCTCC AACGTCTGCT 360 TTGATGAGTT CTTCCCTGTG TCCCATGTGC GCCTCTGGGC CCTGCAGCTT ATCCTGGTGA 420 CATGCCCCTC ACTGCTCGTG GTCATGCACG TGGCCTACCG GGAGGTTCAG GAGAAGAGGC 480 ACCGAGAAGC CCATGGGGAG AACAGTGGGC GCCTCTACCT GAACCCCGGC AAGAAGCGGG 540 GTGGGCTCTG GTGGACATAT GTCTGCAGCC TAGTGTTCAA GGCGAGCGTG GACATCGCCT 600 TTCTCTATGT GTTCCACTCA TTCTACCCCA AATATATCCT CCCTCCTGTG GTCAAGTGCC 660 ACGCAGATCC ATGTCCCAAT ATAGTGGACT GCTTCATCTC CAAGCCCTCA GAGAAGAACA 720 TTTTCACCCT CTTCATGGTG GCCACAGCTG CCATCTGCAT CCTGCTCAAC CTCGTGGAGC 780 TCATCTACCT GGTGAGCAAG AGATGCCACG AGTGCCTGGC AGCAAGGAAA GCTCAAGCCA 840 TGTGCACAGG TCATCACCCC CACGGTACCA CCTCTTCCTG CAAACAAGAC GACCTCCTTT 900 CGGGTGACCT CATCTTTCTG GGCTCAGACA GTCATCCTCC TCTCTTACCA GACCGCCCCC 960 GAGACCATGT GAAGAAAACC ATCTTGTGAG GGGCTGCCTG GACTGGTCTG GCAGGTTGGG 1020 CCTGGATGGG GAGGCTCTAG CATCTCTCAT AGGTGCAACC TGAGAGTGGG GGAGCTAAGC 1080 CATGAGGTAG GGGCAGGCAA GAGAGAGGAT TCAGACGCTC TGGGAGCCAG TTCCTAGTCC 1140 TCAACTCCAG CCACCTGCCC CAGCTCGACG GCACTGGGCC AGTTCCCCCT CTGCTCTGCA 1200 GCTCGGTTTC CTTTTCTAGA ATGGAAATAG TGAGGGCCAA TGC

Seq ID NO: 545 Protein sequence Protein Accession ft: NP 005259.1

11 21 31 41 51

MNWSIFEGLL S IGVNKYSTAF GRIWLSLVFI FRVLVYLVTA ERVWSDDHKD FDCNTRQPGC 60

SNVCFDEFFP VSHVRLWALQ LILVTCPSLL WMHVAYREV QEKRHREAHG ENSGRLYLNP 120

GKKRGGLWWT YVCSLVFKAS VDIAFLYVFH SFYPKYILPP WKCHADPCP NIVDCFISKP 180

SEKNIFTLFM VATAAICILL NLVELIYLVS KRCHECLAAR KAQAMCTGHH PHGTTSSCKQ 240 DDLLSGDLIF LGSDSHPPLL PDRPRDHVKK TIL

Seq ID NO: 546 DNA sequence

Nucleic Acid Accession ft: NM_00239l.l

Coding sequence: 26.. 57

11 21 31 41 51

CGGGCGAAGC AGCGCGGGCA GCGAGATGCA GCACCGAGGC TTCCTCCTCC TCACCCTCCT 60 CGCCCTGCTG GCGCTCACCT CCGCGGTCGC CAAAAAGAAA GATAAGGTGA AGAAGGGCGG 120 CCCGGGGAGC GAGTGCGCTG AGTGGGCCTG GGGGCCCTGC ACCCCCAGCA GCAAGGATTG 180 CGGCGTGGGT TTCCGCGAGG GCACCTGCGG GGCCCAGACC CAGCGCATCC GGTGCAGGGT 240 GCCCTGCAAC TGGAAGAAGG AGTTTGGAGC CGACTGCAAG TACAAGTTTG AGAACTGGGG 300 TGCGTGTGAT GGGGGCACAG GCACCAAAGT CCGCCAAGGC ACCCTGAAGA AGGCGCGCTA 360 CAATGCTCAG TGCCAGGAGA CCATCCGCGT CACCAAGCCC TGCACCCCCA AGACCAAAGC 420 AAAGGCCAAA GCCAAGAAAG GGAAGGGAAA GGACTAGACG CCAAGCCTGG ATGCCAAGGA 480 GCCCCTGGTG TCACATGGGG CCTGGCCACG CCCTCCCTCT CCCAGGCCCG AGATGTGACC 540 CACCAGTGCC TTCTGTCTGC TCGTTAGCTT TAATCAATCA TGCCCTGCCT TGTCCCTCTC 600 ACΓCCCCAGC CCCACCCCTA AGTGCCCAAA GTGGGGAGGG ACAAGGGATT CTGGGAAGCT 660 TGAGCCTCCC CCAAAGCAAT GTGAGTCCCA GAGCCCGCTT TTGTTCTTCC CCACAATTCC 720 ATTACTAAGA AACACATCAA ATAAACTGAC TTTTTCCCCC CAATAAAAGC TCTTCTTTTT 780

TAATAT

Seq ID NO: 547 Protein sequence Protein Accession ft: NP 002382.1

11 21 31 41 51

MQHRGFLLLT LLALLALTSA VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT 60 CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI 120 RVTKPCTPKT KAKAKAKKGK GKD

Seq ID NO: 548 DNA sequence Nucleic Acid Accession ft: NM_006783.1 Coding sequence: 1..786

1 11 21 31 41 51

I I I I I I

ATGGATTGGG GGACGCTGCA CACTTTCATC GGGGGTGTCA ACAAACACTC CACCAGCATC 60

GGGAAGGTGT GGATCACAGT CATCTTTATT TTCCGAGTCA TGATCCTAGT GGTGGCTGCC 120

CAGGAAGTGT GGGGTGACGA GCAAGAGGAC TTCGTCTGCA ACACACTGCA ACCGGGATGC 180

AAAAATGTGT GCTATGACCA CTTTTTCCCG GTGTCCCACA TCCGGCTGTG GGCCCTCCAG 240

CTGATCTTCG TCTCCACCCC AGCGCTGCTG GTGGCCATGC ATGTGGCCTA CTACAGGCAC 300

GAAACCACTC GCAAGTTCAG GCGAGGAGAG AAGAGGAATG ATTTCAAAGA CATAGAGGAC 360

ATTAAAAAGC ACAAGGTTCG GATAGAGGGG TCGCTGTGGT GGACGTACAC CAGCAGCATC 420

TTTTTCCGAA TCATCTTTGA AGCAGCCTTT ATGTATGTGT TTTACTTCCT TTACAATGGG 480

TACCACCTGC CCTGGGTGTT GAAATGTGGG ATTGACCCCT GCCCCAACCT TGTTGACTGC 540

TTTATTTCTA GGCCAACAGA GAAGACCGTG TTTACCATTT TTATGATTTC TGCGTCTGTG 600

ATTTGCATGC TGCTTAACGT GGCAGAGTTG TGCTACCTGC TGCTGAAAGT GTGTTTTAGG 660

AGATCAAAGA GAGCACAGAC GCAAAAAAAT CACCCCAATC ATGCCCTAAA GGAGAGTAAG 720

CAGAATGAAA TGAATGAGCT GATTTCAGAT AGTGGTCAAA ATGCAATCAC AGGTTTCCCA 780 AGCTAA

Seq ID NO: 549 Protein sequence Protein Accession ft: NP_006774.1 1 11 21 31 41 51 i i i i i i

MDWGTLHTFI GGVNKHSTSI GKVWITVIFI FRVMILWAA QEVWGDEQED FVCNTLQPGC 60

KNVCYDHFFP VSHIRLWALQ LIFVSTPALL VAMHVAYYRH ETTRKFRRGE KRNDFKDIED 120

IKKHKVRIEG SLWWTYTSSI FFRIIFEAAF MYVFYFLYNG YHLPWVLKCG IDPCPNLVDC 180

FISRPTEKTV FTIFMISASV ICMLLNVAEL CYLLLKVCFR RSKRAQTQKN HPNHALKESK 240 QNEMNELISD SGQNAITGFP S

Seq ID NO: 550 DNA sequence

Nucleic Acid Accession ft: NM_002571.1

Coding sequence: 99..587

1 11 21 31 41 51

I I I I I I

CATCCCTCTG GCTCCAGAGC TCAGAGCCAC CCACAGCCGC AGCCATGCTG TGCCTCCTGC 60

TCACCCTGGG CGTGGCCCTG GTCTGTGGTG TCCCGGCCAT GGACATCCCC CAGACCAAGC 120

AGGACCTGGA GCTCCCAAAG TTGGCAGGGA CCTGGCACTC CATGGCCATG GCGACCAACA 180

ACATCTCCCT CATGGCGACA CTGAAGGCCC CTCTGAGGGT CCACATCACC TCACTGTTGC 240

CCACCCCCGA GGACAACCTG GAGATCGTTC TGCACAGATG GGAGAACAAC AGCTGTGTTG 300

AGAAGAAGGT CCTTGGAGAG AAGACTGGGA ATCCAAAGAA GTTCAAGATC AACTATACGG 360

TGGCGAACGA GGCCACGCTG CTCGATACTG ACTACGACAA TTTCCTGTTT CTCTGCCTAC 420

AGGACACCAC CACCCCCATC CAGAGCATGA TGTGCCAGTA CCTGGCCAGA GTCCTGGTGG 480

AGGACGATGA GATCATGCAG GGATTCATCA GGGCTTTCAG GCCCCTGCCC AGGCACCTAT 540

GGTACTTGCT GGACTTGAAA CAGATGGAAG AGCCGTGCCG TTTCTAGCTC ACCTCCGCCT 600

CCAGGAAGAC CAGACTCCCA CCCTTCCACA CCTCCAGAGC AGTGGGACTT CCTCCTGCCC 660

TTTCAAAGAA TAACCACAGC TCAGAAGACG ATGACGTGGT CATCTGTGTC GCCATCCCCT 720

TCCTGCTGCA CACCTGCACC ATTGCCATGG GGAGGCTGCT CCCTGGGGGC AGAGTCTCTG 780 GCAGAGGTTA TTAATAAACC CTTGGAGCAT G

Seq ID NO: 551 Protein sequence Protein Accession ft: NP_002562.1

1 11 21 31 41 51

I I I I I I

MDIPQTKQDL ELPKLAGTWH SMAMATNNIS LMATLKAPLR VHITSLLPTP EDNLEIVLHR 60

WENNSCVEKK VLGEKTGNPK KFKINYTVAN EATLLDTDYD NFLFLCLQDT TTPIQSMMCQ 120 YLARVLVEDD EIMQGFIRAF RPLPRHLWYL LDLKQMEEPC RF

Seq ID NO: 552 DNA sequence

Nucleic Acid Accession ft: NM_006500.1

Coding sequence: 27..1967

1 11 21 31 41 51

I I I I I I

ACTTGCGTCT CGCCCTCCGG CCAAGCATGG GGCTTCCCAG GCTGGTCTGC GCCTTCTTGC 60

TCGCCGCCTG CTGCTGCTGT CCTCGCGTCG CGGGTGTGCC CGGAGAGGCT GAGCAGCCTG 120

CGCCTGAGCT GGTGGAGGTG GAAGTGGGCA GCACAGCCCT TCTGAAGTGC GGCCTCTCCC 180

AGTCCCAAGG CAACCTCAGC CATGTCGACT GGTTTTCTGT CCACAAGGAG AAGCGGACGC 240

TCATCTTCCG TGTGCGCCAG GGCCAGGGCC AGAGCGAACC TGGGGAGTAC GAGCAGCGGC 300

TCAGCCTCCA GGACAGAGGG GCTACTCTGG CCCTGACTCA AGTCACCCCC CAAGACGAGC 360

GCATCTTCTT GTGCCAGGGC AAGCGCCCTC GGTCCCAGGA GTACCGCATC CAGCTCCGCG 420

TCTACAAAGC TCCGGAGGAG CCAAACATCC AGGTCAACCC CCTGGGCATC CCTGTGAACA 480

GTAAGGAGCC TGAGGAGGTC GCTACCTGTG TAGGGAGGAA CGGGTACCCC ATTCCTCAAG 540

TCATCTGGTA CAAGAATGGC CGGCCTCTGA AGGAGGAGAA GAACCGGGTC CACATTCAGT 600

CGTCCCAGAC TGTGGAGTCG AGTGGTTTGT ACACCTTGCA GAGTATTCTG AAGGCACAGC 660

TGGTTAAAGA AGACAAAGAT GCCCAGTTTT ACTGTGAGCT CAACTACCGG CTGCCCAGTG 720

GGAACCACAT GAAGGAGTCC AGGGAAGTCA CCGTCCCTGT TTTCTACCCG ACAGAAAAAG 780

TGTGGCTGGA AGTGGAGCCC GTGGGAATGC TGAAGGAAGG GGACCGCGTG GAAATCAGGT 840

GTTTGGCTGA TGGCAACCCT CCACCACACT TCAGCATCAG CAAGCAGAAC CCCAGCACCA 900

GGGAGGCAGA GGAAGAGACA ACCAACGACA ACGGGGTCCT GGTGCTGGAG CCTGCCCGGA 960

AGGAACACAG TGGGCGCTAT GAATGTCAGG CCTGGAACTT GGACACCATG ATATCGCTGC 1020

TGAGTGAACC ACAGGAACTA CTGGTGAACT ATGTGTCTGA CGTCCGAGTG AGTCCCGCAG 1080

CCCCTGAGAG ACAGGAAGGC AGCAGCCTCA CCCTGACCTG TGAGGCAGAG AGTAGCCAGG 1140

ACCTCGAGTT CCAGTGGCTG AGAGAAGAGA CAGACCAGGT GCTGGAAAGG GGGCCTGTGC 1200 TTCAGTTGCA TGACCTGAAA CGGGAGGCAG GAGGCGGCTA TCGCTGCGTG GCGTCTGTGC 1260

CCAGCATACC CGGCCTGAAC CGCACACAGC TGGTCAAGCT GGCCATTTTT GGCCCCCCTT 1320

GGATGGCATT CAAGGAGAGG AAGGTGTGGG TGAAAGAGAA TATGGTGTTG AATCTGTCTT 1380

GTGAAGCGTC AGGGCACCCC CGGCCCACCA TCTCCTGGAA CGTCAACGGC ACGGCAAGTG 1440

AACAAGACCA AGATCCACAG CGAGTCCTGA GCACCCTGAA TGTCCTCGTG ACCCCGGAGC 1500

TGTTGGAGAC AGGTGTTGAA TGCACGGCCT CCAACGACCT GGGCAAAAAC ACCAGCATCC 1560

TCTTCCTGGA GCTGGTCAAT TTAACCACCC TCACACCAGA CTCCAACACA ACCACTGGCC 1620

TCAGCACTTC CACTGCCAGT CCTCATACCA GAGCCAACAG CACCTCCACA GAGAGAAAGC 1680

TGCCGGAGCC GGAGAGCCGG GGCGTGGTCA TCGTGGCTGT GATTGTGTGC ATCCTGGTCC 1740

TGGCGGTGCT GGGCGCTGTC CTCTATTTCC TCTATAAGAA GGGCAAGCTG CCGTGCAGGC 1800

GCTCAGGGAA GCAGGAGATC ACGCTGCCCC CGTCTCGTAA GACCGAACTT GTAGTTGAAG 1860

TTAAGTCAGA TAAGCTCCCA GAAGAGATGG GCCTCCTGCA GGGCAGCAGC GGTGACAAGA 1920

GGGCTCCGGG AGACCAGGGA GAGAAATACA TCGATCTGAG GCATTAGCCC CGAATCACTT 1980

CAGCTCCCTT CCCTGCCTGG ACCATTCCCA GCTCCCTGCT CACTCTTCTC TCAGCCAAAG 2040

CCTCCAAAGG GACTAGAGAG AAGCCTCCTG CTCCCCTCAC CTGCACACCC CCTTTCAGAG 2100

GGCCACTGGG TTAGGACCTG AGGACCTCAC TTGGCCCTGC AAGCCGCTTT TCAGGGACCA 2160

GTCCACCACC ATCTCCTCCA CGTTGAGTGA AGCTCATCCC AAGCAAGGAG CCCCAGTCTC 2220

CCGAGCGGGT AGGAGAGTTT CTTGCAGAAC GTGTTTTTTC TTTACACACA TTATGGCTGT 2280

AAATACCTGG CTCCTGCCAG CAGCTGAGCT GGGTAGCCTC TCTGAGCTGG TTTCCTGCCC 2340

CAAAGGCTGG CTTCCACCAT CCAGGTGCAC CACTGAAGTG AGGACACACC GGAGCCAGGC 2400

GCCTGCTCAT GTTGAAGTGC GCTGTTCACA CCCGCTCCGG AGAGCACCCC AGCGGCATCC 2460

AGAAGCAGCT GCAGTGTTGC TGCCACCACC CTCCTGCTCG CCTCTTCAAA GTCTCCTGTG 2520

ACATTTTTTC TTTGGTCAGA AGCCAGGAAC TGGTGTCATT CCTTAAAAGA TACGTGCCGG 2580

GGCCAGGTGT GGTGGCTCAC GCCTGTAATC CCAGCACTTT GGGAGGCCGA GGCGGGCGGA 2640

TCACAAAGTC AGGACGAGAC CATCCTGGCT AACACGGTGA AACCCTGTCT CTACTAAAAA 2700

TACAAAAAAA AATTAGCTAG GCGTAGTGGT TGGCACCTAT AGTCCCAGCT ACTCGGAAGG 2760

CTGAAGCAGG AGAATGGTAT GAATCCAGGA GGTGGAGCTT GCAGTGAGCC GAGACCGTGC 2820

CACTGCACTC CAGCCTGGGC AACACAGCGA GACTCCGTCT CGAGGAAAAA AAAAGAAAAG 2880

ACGCGTACCT GCGGTGAGGA AGCTGGGCGC TGTTTTCGAG TTCAGGTGAA TTAGCCTCAA 2940

TCCCCGTGTT CACTTGCTCC CATAGCCCTC TTGATGGATC ACGTAAAACT GAAAGGCAGC 3000

GGGGAGCAGA CAAAGATGAG GTCTACACTG TCCTTCATGG GGATTAAAGC TATGGTTATA 3060

TTAGCACCAA ACTTCTACAA ACCAAGCTCA GGGCCCCAAC CCTAGAAGGG CCCAAATGAG 3120

AGAATGGTAC TTAGGGATGG AAAACGGGGC CTGGCTAGAG CTTCGGGTGT GTGTGTGTGT 3180

CTGTGTGTAT GCATACATAT GTGTGTATAT ATGGTTTTGT CAGGTGTGTA AATTTGCAAA 3240

TTGTTTCCTT TATATATGTA TGTATATATA TATATGAAAA TATATATATA TATGAAAAAT 3300

AAAGCTTAAT TGTCCCAGAA AATCATACAT TGCTTTTTTA TTCTACATGG GTACCACAGG 3360

AACCTGGGGG CCTGTGAAAC TACAACCAAA AGGCACACAA AACCGTTTCC AGTTGGCAGC 3420

AGAGATCAGG GGTTACCTCT GCTTCTGAGC AAATGGCTCA AGCTCTACCA GAGCAGACAG 3480

CTACCCTACT TTTCAGCAGC AAAACGTCCC GTATGACGCA GCACGAAGGG CCTGGCAGGC 3540 TGTTAGCAGG AGCTATGTCC CTTCCTATCG TTTCCGTCCA CTT

Seq ID NO: 553 Protein sequence Protein Accession ft: NP_006491.1

1 11 21 31 41 51

I I I I I I

GLPRLVCAFL LAACCCCPRV AGVPGEAEQP APELVEVEVG STALLKCGLS QSQGNLSHVD 60

WFSVHKEKRT LIFRVRQGQG QSEPGEYEQR LSLQDRGATL ALTQVTPQDE RIFLCQGKRP 120

RSQEYRIQLR VYKAPEEPNI QVNPLGIPVN SKEPEEVATC VGRNGYPIPQ VIWYKNGRPL 180

KEEKNRVHIQ SSQTVESSGL YTLQSILKAQ LVKEDKDAQF YCELNYRLPS GNHMKESREV 240

TVPVFYPTEK VWLEVEPVGM LKEGDRVEIR CLADGNPPPH FSISKQNPST REAEEETTND 300

NGVLVLEPAR KEHSGRYECQ AWNLDTMISL LSEPQELLVN YVSDVRVSPA APERQEGSSL 360

TLTCEAESSQ DLEFQWLREE TDQVLERGPV LQLHDLKREA GGGYRCVASV PSIPGLNRTQ 420

LVKLAIFGPP WMAFKERKVW VKENMVLNLS CEASGHPRPT ISWNVNGTAS EQDQDPQRVL 480

STLNVLVTPE LLETGVECTA SNDLGKNTSI LFLELVNLTT LTPDSNTTTG LSTSTASPHT 540

RANSTSTERK LPEPESRGW IVAVIVCILV LAVLGAVLYF LYKKGKLPCR RSGKQEITLP 600 PSRKTELWE VKSDKLPEEM GLLQGSSGDK RAPGDQGEKY IDLRH Seq ID NO: 554 DNA sequence Nucleic Acid Accession ft: NM_003183.3 Coding sequence: 165..2639

1 11 21 31 41 51

T ICGAGCCTGG CIGGTAGAATC TITCCCAGTAG GICGGCGCGGG AIGGGAAAAGA GIGATTGAGGG 60

GCTAGGCCGG GCGGATCCCG TCCTCCCCCG ATGTGAGCAG TTTTCCGAAA CCCCGTCAGG 120

CGAAGGCTGC GCAGAGAGGT GGAGTCGGTA GCGGGGCCGG GAACATGAGG CAGTCTCTCC 180

TATTCCTGAC CAGCGTGGTT CCTTTCGTGC TGGCGCCGCG ACCTCCGGAT GACCCGGGCT 240

TCGGCCCCCA CCAGAGACTC GAGAAGCTTG ATTCTTTGCT CTCAGACTAC GATATTCTCT 300

CTTTATCTAA TATCCAGCAG CATTCGGTAA GAAAAAGAGA TCTACAGACT TCAACACATG 360

TAGAAACACT ACTAACTTTT TCAGCTTTGA AAAGGCATTT TAAATTATAC CTGACATCAA 420

GTACTGAACG^' TTTTTCACAA AATTTCAAGG TCGTGGTGGT GGATGGTAAA AACGAAAGCG 480

AGTACACTGC AAAATGGCAG GACTTCTTCA CTGGACACGT GGTTGGTGAG CCTGACTCTA 540

GGGTTCTAGC CCACATAAGA GATGATGATG TTATAATCAG AATCAACACA GATGGGGCCG 600

AATATAACAT AGAGCCACTT TGGAGATTTG TTAATGATAC CAAAGACAAA AGAATGTTAG 660

TTTATAAATC TGAAGATATC AAGAATGTTT CACGTTTGCA GTCTCCAAAA GTGTGTGGTT 720

ATTTAAAAGT GGATAATGAA GAGTTGCTCC CAAAAGGGTT AGTAGACAGA GAACCACCTG 780

AAGAGCTTGT TCATCGAGTG AAAAGAAGAG CTGACCCAGA TCCCATGAAG AACACGTGTA 840

AATTATTGGT GGTAGCAGAT CATCGCTTCT ACAGATACAT GGGCAGAGGG GAAGAGAGTA 900

CAACTACAAA TTACTTAATA GAGCTAATTG ACAGAGTTGA TGACATCTAT CGGAACACTT 960

CATGGGATAA TGCAGGTTTT AAAGGCTATG GAATACAGAT AGAGCAGATT CGCATTCTCA 1020

AGTCTCCACA AGAGGTAAAA CCTGGTGAAA AGCACTACAA CATGGCAAAA AGTTACCCAA 1080

ATGAAGAAAA GGATGCTTGG GATGTGAAGA TGTTGCTAGA GCAATTTAGC TTTGATATAG 1140

CTGAGGAAGC ATCTAAAGTT TGCTTGGCAC ACCTTTTCAC ATACCAAGAT TTTGATATGG 1200

GAACTCTTGG ATTAGCTTAT GTTGGCTCTC CCAGAGCAAA CAGCCATGGA GGTGTTTGTC 1260

CAAAGGCTTA TTATAGCCCA GTTGGGAAGA AAAATATCTA TTTGAATAGT GGTTTGACGA 1320

GCACAAAGAA TTATGGTAAA ACCATCCTTA CAAAGGAAGC TGACCTGGTT ACAACTCATG 1380 AATTGGGACA TAATTTTGGA GCAGAACATG ATCCGGATGG TCTAGCAGAA TGTGCCCCGA 1440 ATGAGGACCA GGGAGGGAAA TATGTCATGT ATCCCATAGC TGTGAGTGGC GATCACGAGA 1500 ACAATAAGAT GTTTTCAAAC TGCAGTAAAC AATCAATCTA TAAGACCATT GAAAGTAAGG 1560 CCCAGGAGTG TTTTCAAGAA CGCAGCAATA AAGTTTGTGG GAACTCGAGG GTGGATGAAG 1620 GAGAAGAGTG TGATCCTGGC ATCATGTATC TGAACAACGA CACCTGCTGC AACAGCGACT 1680 GCACGTTGAA GGAAGGTGTC CAGTGCAGTG ACAGGAACAG TCCTTGCTGT AAAAACTGTC 1740 AGTTTGAGAC TGCCCAGAAG AAGTGCCAGG AGGCGATTAA TGCTACTTGC AAAGGCGTGT 1800 CCTACTGCAC AGGTAATAGC AGTGAGTGCC CGCCTCCAGG AAATGCTGAA AATGACACTG 1860 TTTGCTTGGA TCTTGGCAAG TGTAAGGATG GGAAATGCAT CCCTTTCTGC GAGAGGGAAC 1920 AGCAGCTGGA GTCCTGTGCA TGTAATGAAA CTGACAACTC CTGCAAGGTG TGCTGCAGGG 1980 ACCTTTCTGG CCGCTGTGTG CCCTATGTCG ATGCTGAACA AAAGAACTTA TTTTTGAGGA 2040 AAGGAAAGCC CTGTACAGTA GGATTTTGTG ACATGAATGG CAAATGTGAG AAACGAGTAC 2100 AGGATGTAAT TGAACGATTT TGGGATTTCA TTGACCAGCT GAGCATCAAT ACTTTTGGAA 2160 AGTTTTTAGC AGACAACATC GTTGGGTCTG TCCTGGTTTT CTCCTTGATA TTTTGGATTC 2220 CTTTCAGCAT TCTTGTCCAT TGTGTGGATA AGAAATTGGA TAAACAGTAT GAATCTCTGT 2280 CTCTGTTTCA CCCCAGTAAC GTCGAAATGC TGAGCAGCAT GGATTCTGCA TCGGTTCGCA 2340 TTATCAAACC CTTTCCTGCG CCCCAGACTC CAGGCCGCCT GCAGCCTGCC CCTGTGATCC 2400 CTTCGGCGCC AGCAGCTCCA AAACTGGACC ACCAGAGAAT GGACACCATC CAGGAAGACC 2460 CCAGCACAGA CTCCCATATG GACGAGGATG GGTTTGAGAA GGACCCCTTC CCAAATAGCA 2520 GCACAGCTGC CAAGTCATTT GAGGATCTCA CGGACCATCC GGTCGCCAGA AGTGAAAAGG 2580 CTGCCTCCTT TAAACTGCAG CGTCAGAATC GTGTTAACAG CAAAGAAACA GAGTGCTAAT 2640 TTAGTTCTCA GCTCTTCTGA CTTAAGTGTG CAAAATATTT TTATAGATTT GACCTACAAA 2700 TCAATCACAG CTTGTATTTT GTGAAGACTG GGAAGTGACT TAGCAGATGC TGGTCATGTG 2760 TTTGAACTTC CTGCAGGTAA ACAGTTCTTG TGTGGTTTGG CCCTTCTCCT TTTGAAAAGG 2820 TAAGGTGAAA GTGAATCTAC TTATTTTGAG GCTTTCAGGT TTTAGTTTTT AAAATATCTT 2880 TTGACCTGTG GTGCAAAAGC AGAAAATACA GCTGGATTGG GTTATGAATA TTTACGTTTT 2940 TGTAAATTAA TCTTTTATAT TGATAACAGC ACTGACTAGG GAAATGATCA GTTTTTTTTT 3000 ATACACTGTA ATGAACCGCT GAATATGAAG CATTTGGCAT TTATTTGTGA GAAAAGTGGA 3060 ATAGTTTTTT TTTTTTTTTT TTTTTTTTGC CTTCAACTAA AAACAAAGGA GATAAATTTA 3120 GTATACATTG TATCTAAATT GTGGGTCTAT TTCTAGTTAT TACCCAGAGT TTTTATGTAG 3180 CAGGGAAAAT ATATATCTAA ATTTAGAAAT CATTTGGGTT AATATGGCTC TTCATAATTC 3240 TAAGACTAAT GCTCAGAACC TAACCACTAC CTTACAGTGA GGGCTATACA TGGTAGCCAG 3300 TTGAATTTAT GGAATCTACC AACTGTTTAG GGCCCTGATT TGCTGGGCAG TTTTTCTGTA 3360 TTTTATAAGT ATCTTCATGT ATCCCTGTTA CTGATAGGGA TACATGTCTT AGAAAATTCA 3420 CTATTGGCTG GGAGTGGTGG CTCATGCCTG TAATCCCAGC ACTTGGAGAG GCTGAGGTTG 3480 CGCCACTACA CTCCAGCCTG GGTGACAGAG TGAGATCTGC CTC

Seq ID NO: 555 Protein sequence Protein Accession ft: NP 003174.2

MRQSLLFLTS WPFVLAPRP PDDPGFGPHQ RLEKLDSLLS DYDILSLSNI QQHSVRKRDL 60

QTSTHVETLL TFSALKRHFK LYLTSSTERF SQNFKWWD GKNESEYTAK WQDFFTGHW 120

GEPDSRVLAH IRDDDVIIRI NTDGAEYNIE PLWRFVNDTK DKRMLVYKSE DIKNVSRLQS 180

PKVCGYLKVD NEELLPKGLV DREPPEELVH RVKRRADPDP MKNTCKLLW ADHRFYRYMG 240

RGEESTTTNY LIELIDRVDD IYRNTSWDNA GFKGYGIQIE QIRILKSPQE VKPGEKHYNM 300

AKSYPNEEKD AWDVKMLLEQ FSFDIAEEAS KVCLAHLFTY QDFDMGTLGL AYVGSPRANS 360

HGGVCPKAYY SPVGKKNIYL NSGLTSTKNY GKTILTKEAD LVTTHELGHN FGAEHDPDGL 420

AECAPNEDQG GKYVMYPIAV SGDHENNKMF SNCSKQSIYK TIESKAQECF QERSNKVCGN 480

SRVDEGEECD PGIMYLNNDT CCNSDCTLKE GVQCSDRNSP CCKNCQFETA QKKCQEAINA 540

TCKGVSYCTG NSSECPPPGN AENDTVCLDL GKCKDGKCIP FCEREQQLES CACNETDNSC 600

KVCCRDLSGR CVPYVDAEQK NLFLRKGKPC TVGFCDMNGK CEKRVQDVIE RFWDFIDQLS 660

INTFGKFLAD NIVGSVLVFS LIFWIPFSIL VHCVDKKLDK QYESLSLFHP SNVEMLSSMD 720

SASVRIIKPF PAPQTPGRLQ PAPVIPSAPA APKLDHQRMD TIQEDPSTDS HMDEDGFEKD 780

PFPNSSTAAK SFEDLTDHPV ARSEKAASFK LQRQNRVNSK ETEC

Seq ID NO: 556 DNA sequence

Nucleic Acid Accession ft: NM_021832.1

Coding sequence: 164..2248

11 21 31 41 51

TCGAGCCTGG CGGTAGAATC TTCCCAGTAG GCGGCGCGGG AGGAAAAGAG GATTGAGGGG 60 CTAGGCCGGG CGGATCCCGT CCTCCCCCGA TGTGAGCAGT TTTCCGAAAC CCCGTCAGGC 120 GAAGGCTGCC CAGAGAGGTG GAGTCGGTAG CGGGGCCGGG AACATGAGGC AGTCTCTCCT 180 ATTCCTGACC AGCGTGGTTC CTTTCGTGCT GGCGCCGCGA CCTCCGGATG ACCCGGGCTT 240 GGGCCCCCAC CAGAGACTCG AGAAGCTTGA TTCTTTGCTC TCAGACTACG ATATTCTCTC 300 TTTATCTAAT ATCCAGCAGC ATTCGGTAAG AAAAAGAGAT CTACAGACTT CAACACATGT 360 AGAAACACTA CTAACTTTTT CAGCTTTGAA AAGGCATTTT AAATTATACC TGACATCAAG 420 TACTGAACGT TTTTCACAAA ATTTCAAGGT GGTGGTGGTG GATGGTAAAA ACGAAAGCGA 480 GTACACTGTA AAATGGCAGG ACTTCTTCAC TGGACACGTG GTTGGTGAGC CTGACTCTAG 540 GGTTCTAGCC CACATAAGAG ATGATGATGT TATAATCAGA ATCAACACAG ATGGGGCCGA 600 ATATAACATA GAGCCACTTT GGAGATTTGT TAATGATACC AAAGACAAAA GAATGTTAGT 660 TTATAAATCT GAAGATATCA AGAATGTTTC ACGTTTGCAG TCTCCAAAAG TGTGTGGTTA 720 TTTAAAAGTG GATAATGAAG AGTTGCTCCC AAAAGGGTTA GTAGACAGAG AACCACCTGA 780 AGAGCTTGTT CATCGAGTGA AAAGAAGAGC TGACCCAGAT CCCATGAAGA ACACGTGTAA 840 ATTATTGGTG GTAGCAGATC ATCGCTTCTA CAGATACATG GGCAGAGGGG AAGAGAGTAC 900 AACTACAAAT TACTTAATAG AGCTAATTGA CAGAGTTGAT GACATCTATC GGAACACTTC 960 ATGGGATAAT GCAGGTTTTA AAGGCTATGG AATACAGATA GAGCAGATTC GCATTCTCAA 1020 GTCTCCACAA GAGGTAAAAC CTGGTGAAAA GCACTACAAC ATGGCAAAAA GTTACCCAAA 1080 TGAAGAAAAG GATGCTTGGG ATGTGAAGAT GTTGCTAGAG CAATTTAGCT TTGATATAGC 1140 TGAGGAAGCA TCTAAAGTTT GCTTGGCACA CCTTTTCACA TACCAAGATT TTGATATGGG 1200 AACTCTTGGA TTAGCTTATG TTGGCTCTCC CAGAGCAAAC AGCCATGGAG GTGTTTGTCC 1260 AAAGGCTTAT TATAGCCCAG TTGGGAAGAA AAATATCTAT TTGAATAGTG GTTTGACGAG 1320 CACAAAGAAT TATGGTAAAA CCATCCTTAC AAAGGAAGCT GACCTGGTTA CAACTCATGA 1380 ATTGGGACAT AATTTTGGAG CAGAACATGA TCCGGATGGT CTAGCAGAAT GTGCCCCGAA 1440 TGAGGACCAG GGAGGGAAAT ATGTCATGTA TCCCATAGCT GTGAGTGGCG ATCACGAGAA 1500

CAATAAGATG TTTTCAAACT GCAGTAAACA ATCAATCTAT AAGACCATTG AAAGTAAGGC 1560

CCAGGAGTGT TTTCAAGAAC GCAGCAATAA AGTTTGTGGG AACTCGAGGG TGGATGAAGG 1620

AGAAGAGTGT GATCCTGGCA TCATGTATCT GAACAACGAC ACCTGCTGCA ACAGCGACTG 1680

CACGTTGAAG GAAGGTGTCC AGTGCAGTGA CAGGAACAGT CCTTGCTGTA AAAACTGTCA 1740

GTTTGAGACT GCCCAGAAGA AGTGCCAGGA GGCGATTAAT GCTACTTGCA AAGGCGTGTC 1800

CTACTGCACA GGTAATAGCA GTGAGTGCCC GCCTCCAGGA AATGCTGAAG ATGACACTGT 1860

TTGCTTGGAT CTTGGCAAGT GTAAGGATGG GAAATGCATC CCTTTCTGCG AGAGGGAACA 1920

GCAGCTGGAG TCCTGTGCAT GTAATGAAAC TGACAACTCC TGCAAGGTGT GCTGCAGGGA 1980

CCTTTCCGGC CGCTGTGTGC CCTATGTCGA TGCTGAACAA AAGAACTTAT TTTTGAGGAA 2040

AGGAAAGCCC TGTACAGTAG GATTTTGTGA CATGAATGGC AAATGTGAGA AACGAGTACA 2100

GGATGTAATT GAACGATTTT GGGATTTCAT TGACCAGCTG AGCATCAATA CTTTTGGAAA 2160

GTTTTTAGCA GACAACATCG TTGGGTCTGT CCTGGTTTTC TCCTTGATAT TTTGGATTCC 2220

TTTCAGCATT CTTGTCCATT GTGTGTAACG TCGAAATGCT GAGCAGCATG GATTCTGCAT 2280

CGGTTCGCAT TATCAAACCC TTTCCTGCGC CCCAGACTCC AGGCCGCCTG CAGCCTGCCC 2340

CTGTGATCCC TTCGGCGCCA GCAGCTCCAA AACTGGACCA CCAGAGAATG GACACCATCC 2400

AGGAAGACCC CAGCACAGAC TCACATATGG ACGAGGATGG GTTTGAGAAG GACCCCTTCC 2460

CAAATAGCAG CACAGCTGCC AAGTCATTTG AGGATCTCAC GGACCATCCG GTCACCAGAA 2520

GTGAAAAGGC TGCCTCCTTT AAACTGCAGC GTCAGAATCG TGTTGACAGC AAAGAAACAG 2580

AGTGCTAATT TAGTTCTCAG CTCTTCTGAC TTAAGTGTGC AAAATATTTT TATAGATTTG 2640

ACCTACAATC AATCACAGCT TATATTTTGT GAAGACTGGG AAGTGACTTA GCAGATGCTG 2700

GTCATGTGTT TGAACTTCCT GCAGGTAAAC AGTTCTTGTG TGGTTTGGCC CTTCTCCTTT 2760

TGAAAAGGTA AGGTGAAGGT GAATCTAGCT TATTTTGAGG CTTTCAGGTT TTAGTTTTTA 2820

AAATATCTTT TGACCTGTGG TGCAAAAGCA GAAAATACAG CTGGATTGGG TTATGAGTAT 2880

TTACGTTTTT GTAAATTAAT CTTTTATATT GATAACAGGC ACTGACTAGG GAAATGATCA 2940

GTTTTTTTTT ATACACTGTA ATGAACCGCT GAATATGAAG CATTTGGCAT TTATTTGTGA 3000

GAAAAGTGGA ATAGTTTTTT TTTTTTTTTT TTTTTTTTGC CTTCAACTAA AAACAAAGGA 3060

GATAAATTTA GTATACATTG TATCTAAATT GTGGGTCTAT TTCTAGTTAT TACCCAGAGT 3120

TTTTATGTAG CAGGGAAAAT ATATATCTAA ATTTAGAAAT CATTTGGGTT AATATGGCTC 3180

TTCATAATTC TAAGACTAAT GCTCAGAACC TAACCACTAC CTTACAGTGA GGGCTATACA 3240

TGGTAGCCAG TTGAATTTAT GGAATCTACC AACTGTTTAG GGCCCTGATT TGCTGGGCAG 3300

TTTTTCTGTA TTTTATAAGT ATCTTCATGT ATCCCTGTTA CTGATAGGGA TACATGTCTT 3360

AGAAAATTCA CTATTGGCTG GGAGTGGTGG CTCATGCCTG TAATCCCAGC ACTTGGAGAG 3420 3421 GCTGAGGTTG CGCCACTACA CTCCAGCCTG GGTGACAGAG TGAGATCTGC CTC

Seq ID NO: 557 Protein sequence Protein Accession ft: NP 068604.1

31 41

MRQSLLFLTS WPFVLAPRP PDDPGFGPHQ RLEKLDSLLS DYDILSLSNI QQHSVRKRDL 60

QTSTHVETLL TFSALKRHFK LYLTSSTERF SQNFKW D GKNESEYTVK WQDFFTGHW 120

GEPDSRVLAH IRDDDVIIRI NTDGAEYNIE PLWRFVNDTK DKRMLVYKSE DIKNVSRLQS 180

PKVCGYLKVD NEELLPKGLV DREPPEELVH RVKRRADPDP MKNTCKLLW ADHRFYRYMG 240

RGEESTTTNY LIELIDRVDD IYRNTSWDNA GFKGYGIQIE QIRILKSPQE VKPGEKHYNM 300

AKSYPNEEKD AWDVKMLLEQ FSFDIAEEAS KVCLAHLFTY QDFDMGTLGL AYVGSPRANS 360

HGGVCPKAYY SPVGKKNIYL NSGLTSTKNY GKTILTKEAD LVTTHELGHN FGAEHDPDGL 420

AECAPNEDQG GKYVMYPIAV SGDHENNKMF SNCSKQSIYK TIESKAQECF QERSNKVCGN 480

SRVDEGEECD PGIMYLNNDT CCNSDCTLKE GVQCSDRNSP CCKNCQFETA QKKCQEAINA 540

TCKGVSYCTG NSSECPPPGN AEDDTVCLDL GKCKDGKCIP FCEREQQLES CACNETDNSC ' ' 600

KVCCRDLSGR CVPYVDAEQK NLFLRKGKPC TVGFCDMNGK CEKRVQDVIE RFWDFIDQLS 660

INTFGKFLAD NIVGSVLVFS LIFWIPFSIL VHCV Seq ID NO: 558 DNA sequence Nucleic Acid Accession ft: NM_004994.1 Coding sequence: 20..2143

11 21 31 41 51

I

AGACACCTCT GCCCTCACCA T IGAGCCTCTG GCAGCCCCTG GTCCTGGTGC T ICCTGGTGCT 60 GGGCTGCTGC TTTGCTGCCC CCAGACAGCG CCAGTCCACC CTTGTGCTCT TCCCTGGAGA 120 CCTGAGAACC AATCTCACCG ACAGGCAGCT GGCAGAGGAA TACCTGTACC GCTATGGTTA 180 CACTCGGGTG GCAGAGATGC GTGGAGAGTC GAAATCTCTG GGGCCTGCGC TGCTGCTTCT 240 CCAGAAGCAA CTGTCCCTGC CCGAGACCGG TGAGCTGGAT AGCGCCACGC TGAAGGCCAT 300 GCGAACCCCA CGGTGCGGGG TCCCAGACCT GGGCAGATTC CAAACCTTTG AGGGCGACCT 360 CAAGTGGCAC CACCACAACA TCACCTATTG GATCCAAAAC TACTCGGAAG ACTTGCCGCG 420 GGCGGTGATT GACGACGCCT TTGCCCGCGC CTTCGCACTG TGGAGCGCGG TGACGCCGCT 480 CACCTTCACT CGCGTGTACA GCCGGGACGC AGACATCGTC ATCCAGTTTG GTGTCGCGGA 540 GCACGGAGAC GGGTATCCCT TCGACGGGAA GGACGGGCTC CTGGCACACG CCTTTCCTCC 600 TGGCCCCGGC ATTCAGGGAG ACGCCCATTT CGACGATGAC GAGTTGTGGT CCCTGGGCAA 660 GGGCGTCGTG GTTCCAACTC GGTTTGGAAA CGCAGATGGC GCGGCCTGCC ACTTCCCCTT 720 CATCTTCGAG GGCCGCTCCT ACTCTGCCTG CACCACCGAC GGTCGCTCCG ACGGCTTGCC 780 CTGGTGCAGT ACCACGGCCA ACTACGACAC CGACGACCGG TTTGGCTTCT GCCCCAGCGA 840 GAGACTCTAC ACCCGGGACG GCAATGCTGA TGGGAAACCC TGCCAGTTTC CATTCATCTT 900 CCAAGGCCAA TCCTACTCCG CCTGCACCAC GGACGGTCGC TCCGACGGCT ACCGCTGGTG 960 CGCCACCACC GCCAACTACG ACCGGGACAA GCTCTTCGGC TTCTGCCCGA CCCGAGCTGA 1020 CTCGACGGTG ATGGGGGGCA ACTCGGCGGG GGAGCTGTGC GTCTTCCCCT TCACTTTCCT 1080 GGGTAAGGAG TACTCGACCT GTACCAGCGA GGGCCGCGGA GATGGGCGCC TCTGGTGCGC 1140 TACCACCTCG AACTTTGACA GCGACAAGAA GTGGGGCTTC TGCCCGGACC AAGGATACAG 1200 TTTGTTCCTC GTGGCGGCGC ATGAGTTCGG CCACGCGCTG GGCTTAGATC ATTCCTCAGT 1260 GCCGGAGGCG CTCATGTACC CTATGTACCG CTTCACTGAG GGGCCCCCCT TGCATAAGGA 1320 CGACGTGAAT GGCATCCGGC ACCTCTATGG TCCTCGCCCT GAACCTGAGC CACGGCCTCC 1380 AACCACCACC ACACCGCAGC CCACGGCTCC CCCGACGGTC TGCCCCACCG GACCCCCCAC 1440 TGTCCACCCC TCAGAGCGCC CCACAGCTGG CCCCACAGGT CCCCCCTCAG CTGGCCCCAC 1500 AGGTCCCCCC ACTGCTGGCC CTTCTACGGC CACTACTGTG CCTTTGAGTC CGGTGGACGA 1560 TGCCTGCAAC GTGAACATCT TCGACGCCAT CGCGGAGATT GGGAACCAGC TGTATTTGTT 1620 CAAGGATGGG AAGTACTGGC GATTCTCTGA GGGCAGGGGG AGCCGGCCGC AGGGCCCCTT 1680 CCTTATCGCC GACAAGTGGC CCGCGCTGCC CCGCAAGCTβ GACTCGGTCT TTGAGGAGCC 1740

GCTCTCCAAG AAGCTTTTCT TCTTCTCTGG GCGCCAGGTG TGGGTGTACA CAGGCGCGTC 1800

GGTGCTGGGC CCGAGGCGTC TGGACAAGCT GGGCCTGGGA GCCGACGTGG CCCAGGTGAC 1860

CGGGGCCCTC CGGAGTGGCA GGGGGAAGAT GCTGCTGTTC AGCGGGCGGC GCCTCTGGAG 1920

GTTCGACGTG AAGGCGCAGA TGGTGGATCC CCGGAGCGCC AGCGAGGTGG ACCGGATGTT 1980

CCCCGGGGTG CCTTTGGACA CGCACGACGT CTTCCAGTAC CGAGAGAAAG CCTATTTCTG 2040

CCAGGACCGC TTCTACTGGC GCGTGAGTTC CCGGAGTGAG TTGAACCAGG TGGACCAAGT 2100

GGGCTACGTG ACCTATGACA TCCTGCAGTG CCCTGAGGAC TAGGGCTCCC GTCCTGCTTT 2160

GCAGTGCCAT GTAAATCCCC ACTGGGACCA ACCCTGGGGA AGGAGCCAGT TTGCCGGATA 2220

CAAACTGGTA TTCTGTTCTG GAGGAAAGGG AGGAGTGGAG GTGGGCTGGG CCCTCTCTTC 2280 TCACCTTTGT TTTTTGTTGG AGTGTTTCTA ATAAACTTGG ATTCTCTAAC CTTT

Seq ID NO: 559 Protein sequence Protein Accession ft: NP 004985.1

11 21 31 41 51

MSLWQPLVLV I

LLVLGCCFAA P IRQRQSTLVL F IPGDLRTNLT D IRQLAEEYLY R IYGYTRVAEM 60 RGESKSLGPA LLLLQKQLSL PETGELDSAT LKAMRTPRCG VPDLGRFQTF EGDLKWHHHN 120 ITYWIQNYSE DLPRAVIDDA FARAFALWSA VTPLTFTRVY SRDADIVIQF GVAEHGDGYP 180 FDGKDGLLAH AFPPGPGIQG DAHFDDDELW SLGKGVWPT RFGNADGAAC HFPFIFEGRS 240 YSACTTDGRS DGLPWCSTTA NYDTDDRFGF CPSERLYTRD GNADGKPCQF PFIFQGQSYS 300 ACTTDGRSDG YRWCATTANY DRDKLFGFCP TRADSTVMGG NSAGELCVFP FTFLGKEYST 360 CTSEGRGDGR LWCATTSNFD SDKKWGFCPD QGYSLFLVAA HEFGHALGLD HSSVPEALMY 420 PMYRFTEGPP LHKDDVNGIR HLYGPRPEPE PRPPTTTTPQ PTAPPTVCPT GPPTVHPSER 480 PTAGPTGPPS AGPTGPPTAG PSTATTVPLS PVDDACNVNI FDAIAEIGNQ LYLFKDGKYW 540 RFSEGRGSRP QGPFLIADKW PALPRKLDSV FEEPLSKKLF FFSGRQVWVY TGASVLGPRR 600 LDKLGLGADV AQVTGALRSG RGKMLLFSGR RLWRFDVKAQ MVDPRSASEV DRMFPGVPLD 660 THDVFQYREK AYFCQDRFYW RVSSRSELNQ VDQVGYVTYD ILQCPED

Seq ID NO: 560 DNA sequence

Nucleic Acid Accession ft: NM_000213.1

Coding sequence: 127..5385

11 21 31 41 51

CGCCCGCGCG CTGCAGCCCC ATCTCCTAGC GGCAGCCCAG GCGCGGAGGG AGCGAGTCCG 60 CCCCGAGGTA GGTCCAGGAC GGGCGCACAG CAGCAGCCGA GGCTGGCCGG GAGAGGGAGG 120 AAGAGGATGG CAGGGCCACG CCCCAGCCCA TGGGGCAGGC TGCTCCTGGC AGCCTTGATC 180 AGCGTCAGCC TCTCTGGGAC CTTGGCAAAC CGCTGCAAGA AGGCCCCAGT GAAGAGCTGC 240 ACGGAGTGTG TCCGTGTGGA TAAGGACTGC GCCTACTGCA CAGACGAGAT GTTCAGGGAC 300 CGGCGCTGCA ACACCCAGGC GGAGCTGCTG GCCGCGGGCT GCCAGCGGGA GAGCATCGTG 360 GTCATGGAGA GCAGCTTCCA AATCACAGAG GAGACCCAGA TTGACACCAC CCTGCGGCGC 420 AGCCAGATGT CCCCCCAAGG CCTGCGGGTC CGTCTGCGGC CCGGTGAGGA GCGGCATTTT 480 GAGCTGGAGG TGTTTGAGCC ACTGGAGAGC CCCGTGGACC TGTACATCCT CATGGACTTC 540 TCCAACTCCA TGTCCGATGA TCTGGACAAC CTCAAGAAGA TGGGGCAGAA CCTGGCTCGG 600 GTCCTGAGCC AGCTCACCAG CGACTACACT ATTGGATTTG GCAAGTTTGT GGACAAAGTC 660 AGCGTCCCGC AGACGGACAT GAGGCCTGAG AAGCTGAAGG AGCCCTGGCC CAACAGTGAC 720 CCCCCCTTCT CCTTCAAGAA CGTCATCAGC CTGACAGAAG ATGTGGATGA GTTCCGGAAT 780 AAACTGCAGG GAGAGCGGAT CTCAGGCAAC CTGGATGCTC CTGAGGGCGG CTTCGATGCC 840 ATCCTGCAGA CAGCTGTGTG CACGAGGGAC ATTGGCTGGC GCCCGGACAG CACCCACCTG 900 CTGGTCTTCT CCACCGAGTC AGCCTTCCAC TATGAGGCTG ATGGCGCCAA CGTGCTGGCT 960 GGCATCATGA GCCGCAACGA TGAACGGTGC CACCTGGACA CCACGGGCAC CTACACCCAG 1020 TACAGGACAC AGGACTACCC GTCGGTGCCC ACCCTGGTGC GCCTGCTCGC CAAGCACAAC 1080 ATCATCCCCA TCTTTGCTGT CACCAACTAC TCCTATAGCT ACTACGAGAA GCTTCACACC 1140 TATTTCCCTG TCTCCTCACT GGGGGTGCTG CAGGAGGACT CGTCCAACAT CGTGGAGCTG 1200 CTGGAGGAGG CCTTCAATCG GATCCGCTCC AACCTGGACA TCCGGGCCCT AGACAGCCCC 1260 CGAGGCCTTC GGACAGAGGT CACCTCCAAG ATGTTCCAGA AGACGAGGAC TGGGTCCTTT 1320 CACATCCGGC GGGGGGAAGT GGGTATATAC CAGGTGCAGC TGCGGGCCCT TGAGCACGTG 1380 GATGGGACGC ACGTGTGCCA GCTGCCGGAG GACCAGAAGG GCAACATCCA TCTGAAACCT 1440 TCCTTCTCCG ACGGCCTCAA GATGGACGCG GGCATCATCT GTGATGTGTG CACCTGCGAG 1500 CTGCAAAAAG AGGTGCGGTC AGCTCGCTGC AGCTTCAACG GAGACTTCGT GTGCGGACAG 1560 TGTGTGTGCA GCGAGGGCTG GAGTGGCCAG ACCTGCAACT GCTCCACCGG CTCTCTGAGT 1620 GACATTCAGC CCTGCCTGCG GGAGGGCGAG GACAAGCCGT GCTCCGGCCG TGGGGAGTGC 1680 CAGTGCGGGC ACTGTGTGTG CTACGGCGAA GGCCGCTACG AGGGTCAGTT CTGCGAGTAT 1740 GACAACTTCC AGTGTCCCCG CACTTCCGGG TTCCTCTGCA ATGACCGAGG ACGCTGCTCC 1800 ATGGGCCAGT GTGTGTGTGA GCCTGGTTGG ACAGGCCCAA GCTGTGACTG TCCCCTCAGC 1860 AATGCCACCT GCATCGACAG CAATGGGGGC ATCTGTAATG GACGTGGCCA CTGTGAGTGT 1920 GGCCGCTGCC ACTGCCACCA GCAGTCGCTC TACACGGACA CCATCTGCGA GATCAACTAC 1980 TCGGCGATCC ACCCGGGCCT CTGCGAGGAC CTACGCTCCT GCGTGCAGTG CCAGGCGTGG 2040 GGCACCGGCG AGAAGAAGGG. GCGCACGTGT GAGGAATGCA ACTTCAAGGT CAAGATGGTG 2100 GACGAGCTTA AGAGAGCCGA GGAGGTGGTG GTGCGCTGCT CCTTCCGGGA CGAGGATGAC 2160 GACTGCACCT ACAGCTACAC CATGGAAGGT GACGGCGCCC CTGGGCCCAA CAGCACTGTC 2220 CTGGTGCACA AGAAGAAGGA CTGCCCTCCG GGCTCCTTCT GGTGGCTCAT CCCCCTGCTC 2280 CTCCTCCTCC TGCCGCTCCT GGCCCTGCTA CTGCTGCTAT GCTGGAAGTA CTGTGCCTGC 2340 TGCAAGGCCT GCCTGGCACT TCTCCCGTGC TGCAACCGAG GTCACATGGT GGGCTTTAAG 2400 GAAGACCACT ACATGCTGCG GGAGAACCTG ATGGCCTCTG ACCACTTGGA CACGCCCATG 2460 CTGCGCAGCG GGAACCTCAA GGGCCGTGAC GTGGTCCGCT GGAAGGTCAC CAACAACATG 2520 CAGCGGCCTG GCTTTGCCAC TCATGCCGCC AGCATCAACC CCACAGAGCT GGTGCCCTAC 2580 GGGCTGTCCT TGCGCCTGGC CCGCCTTTGC ACCGAGAACC TGCTGAAGCC TGACACTCGG 2640 GAGTGCGCCC AGCTGCGCCA GGAGGTGGAG GAGAACCTGA ACGAGGTCTA CAGGCAGATC 2700 TCCGGTGTAC ACAAGCTCCA GCAGACCAAG TTCCGGCAGC AGCCCAATGC CGGGAAAAAG 2760 CAAGACCACA CCATTGTGGA CACAGTGCTG ATGGCGCCCC GCTCGGCCAA GCCGGCCCTG 2820 CTGAAGCTTA CAGAGAAGCA GGTGGAACAG AGGGCCTTCC ACGACCTCAA GGTGGCCCCC 2880 GGCTACTACA CCCTCACTGC AGACCAGGAC GCCCGGGGCA TGGTGGAGTT CCAGGAGGGC 2940 GTGGAGCTGG TGGACGTACG GGTGCCCCTC TTTATCCGGC CTGAGGATGA CGACGAGAAG 3000 CAGCTGCTGG TGGAGGCCAT CGACGTGCCC GCAGGCACTG CCACCCTCGG CCGCCGCCTG 3060 GTAAACATCA CCATCATCAA GGAGCAAGCC AGAGACGTGG TGTCCTTTGA GCAGCCTGAG 3120

TTCTCGGTCA GCCGCGGGGA CCAGGTGGCC CGCATCCCTG TCATCCGGCG TGTCCTGGAC 3180

GGCGGGAAGT CCCAGGTCTC CTACCGCACA CAGGATGGCA CCGCGCAGGG CAACCGGGAC 3240

TACATCCCCG TGGAGGGTGA GCTGCTGTTC CAGCCTGGGG AGGCCTGGAA AGAGCTGCAG 3300

GTGAAGCTCC TGGAGCTGCA AGAAGTTGAC TCCCTCCTGC GGGGCCGCCA GGTCCGCCGT 3360

TTCCACGTCC AGCTCAGCAA CCCTAAGTTT GGGGCCCACC TGGGCCAGCC CCACTCCACC 3420

ACCATCATCA TCAGGGACCC AGATGAACTG GACCGGAGCT TCACGAGTCA GATGTTGTCA 3480

TCACAGCCAC CCCCTCACGG CGACCTGGGC GCCCCGCAGA ACCCCAATGC TAAGGCCGCT 3540

GGGTCCAGGA AGATCCATTT CAACTGGCTG CCCCCTTCTG GCAAGCCAAT GGGGTACAGG 3600

GTAAAGTACT GGATTCAGGG TGACTCCGAA TCCGAAGCCC ACCTGCTCGA CAGCAAGGTG 3660

CCCTCAGTGG AGCTCACCAA CCTGTACCCG TATTGCGACT ATGAGATGAA GGTGTGCGCC 3720

TACGGGGCTC AGGGCGAGGG ACCCTACAGC TCCCTGGTGT CCTGCCGCAC CCACCAGGAA 3780

GTGCCCAGCG AGCCAGGGCG TCTGGCCTTC AATGTCGTCT CCTCCACGGT GACCCAGCTG 3840

AGCTGGGCTG AGCCGGCTGA GACCAACGGT GAGATCACAG CCTACGAGGT CTGCTATGGC 3900

CTGGTCAACG ATGACAACCG ACCTATTGGG CCCATGAAGA AAGTGCTGGT TGACAACCCT 3960

AAGAACCGGA TGCTGCTTAT TGAGAACCTT CGGGAGTCCC AGCCCTACCG CTACACGGTG 4020

AAGGCGCGCA ACGGGGCCGG CTGGGGGCCT GAGCGGGAGG CCATCATCAA CCTGGCCACC 4080

CAGCCCAAGA GGCCCATGTC CATCCCCATC ATCCCTGACA TCCCTATCGT GGACGCCCAG 4140

AGCGGGGAGG ACTACGACAG CTTCCTTATG TACAGCGATG ACGTTCTACG CTCTCCATCG 4200

GGCAGCCAGA GGCCCAGCGT CTCCGATGAC ACTGAGCACC TGGTGAATGG CCGGATGGAC 4260

TTTGCCTTCC CGGGCAGCAC CAACTCCCTG CACAGGATGA CCACGACCAG TGCTGCTGCC 4320

TATGGCACCC ACCTGAGCCC ACACGTGCCC CACCGCGTGC TAAGCACATC CTCCACCCTC 4380

ACACGGGACT ACAACTCACT GACCCGCTCA GAACACTCAC ACTCGACCAC ACTGCCGAGG 4440

GACTACTCCA CCCTCACCTC CGTCTCCTCC CACGACTCTC GCCTGACTGC TGGTGTGCCC 4500

GACACGCCCA CCCGCCTGGT GTTCTCTGCC CTGGGGCCCA CATCTCTCAG AGTGAGCTGG 4560

CAGGAGCCGC GGTGCGAGCG GCCGCTGCAG GGCTACAGTG TGGAGTACCA GCTGCTGAAC 4620

GGCGGTGAGC TGCATCGGCT CAACATCCCC AACCCTGCCC AGACCTCGGT GGTGGTGGAA 4680

GACCTCCTGC CCAACCACTC CTACGTGTTC CGCGTGCGGG CCCAGAGCCA GGAAGGCTGG 4740

GGCCGAGAGC GTGAGGGTGT CATCACCATT GAATCCCAGG TGCACCCGCA GAGCCCACTG 4800

TGTCCCCTGC CAGGCTCCGC CTTCACTTTG AGCACTCCCA GTGCCCCAGβ CCCGCTGGTG 4860

TTCACTGCCC TGAGCCCAGA CTCGCTGCAG CTGAGCTGGG AGCGGCCACG GAGGCCCAAT 4920

GGGGATATCG TCGGCTACCT GGTGACCTGT GAGATGGCCC AAGGAGGAGG GCCAGCCACC 4980

GCATTCCGGG TGGATGGAGA CAGCCCCGAG AGCCGGCTGA CCGTGCCGGG CCTCAGCGAG 5040

AACGTGCCCT ACAAGTTCAA GGTGCAGGCC AGGACCACTG AGGGCTTCGG GCCAGAGCGC 5100

GAGGGCATCA TCACCATAGA GTCCCAGGAT GGAGGACCCT TCCCGCAGCT GGGCAGCCGT 5160

GCCGGGCTCT TCCAGCACCC GCTGCAAAGC GAGTACAGCA GCATCACCAC CACCCACACC 5220

AGCGCCACCG AGCCCTTCCT AGTGGATGGG CCGACCCTGG GGGCCCAGCA CCTGGAGGCA 5280

GGCGGCTCCC TCACCCGGCA TGTGACCCAG GAGTTTGTGA GCCGGACACT GACCACCAGC 5340

GGAACCCTTA GCACCCACAT GGACCAACAG TTCTTCCAAA CTTGACCGCA CCCTGCCCCA 5400

CCCCCGCCAT GTCCCACTAG GCGTCCTCCC GACTCCTCTC CCGGAGCCTC CTCAGCTACT 5460

CCATCCTTGC ACCCCTGGGG GCCCAGCCCA CCCGCATGCA CAGAGCAGGG GCTAGGTGTC 5520

TCCTGGGAGG CATGAAGGGG GCAAGGTCCG TCCTCTGTGG GCCCAAACCT ATTTGTAACC 5580

AAAGAGCTGG GAGCAGCACA AGGACCCAGC CTTTGTTCTG CACTTAATAA ATGGTTTTGC 5640 TACTG

Seq ID NO: 561 Protein sequence Protein Accession ft: NP 000204.1 1 11 21 31 41 51 i i i i - i i

MAGPRPSPWA RLLLAALISV SLSGTLANRC KKAPVKSCTE CVRVDKDCAY CTDEMFRDRR 60

CNTQAELLAA GCQRESIWM ESSFQITEET QIDTTLRRSQ MSPQGLRVRL RPGEERHFEL 120

EVFEPLESPV DLYILMDFSN SMSDDLDNLK KMGQNLARVL SQLTSDYTIG FGKFVDKVSV 180

PQTDMRPEKL KEPWPNSDPP FSFKNVISLT EDVDEFRNKL QGERISGNLD APEGGFDAIL 240

QTAVCTRDIG WRPDSTHLLV FSTESAFHYE ADGANVLAGI MSRNDERCHL DTTGTYTQYR 300

TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHTYF PVSSLGVLQE DSSNIVELLE 360

EAFNRIRSNL DIRALDSPRG LRTEVTSKMF QKTRTGSFHI RRGEVGIYQV QLRALEHVDG 420

THVCQLPEDQ KGNIHLKPSF SDGLKMDAGI ICDVCTCELQ KEVRSARCSF NGDFVCGQCV 4B0

CSEGWSGQTC NCSTGSLSDI QPCLREGEDK PCSGRGECQC GHCVCYGEGR YEGQFCEYDN 540

FQCPRTSGFL CNDRGRCSMG QCVCEPGWTG PSCDCPLSNA TCIDSNGGIC NGRGHCECGR 600

CHCHQQSLYT DTICEINYSA IHPGLCEDLR SCVQCQAWGT GEKKGRTCEE CNFKVKMVDE 660

LKRAEEVWR CSFRDEDDDC TYSYTMEGDG APGPNSTVLV HKKKDCPPGS FWWLIPLLLL 720

LLPLLALLLL LCWKYCACCK ACLALLPCCN RGHMVGFKED HYMLRENLMA SDHLDTPMLR 780

SGNLKGRDW RWKVTNNMQR PGFATHAASI NPTELVPYGL SLRLARLCTE NLLKPDTREC 840

AQLRQEVEEN LNEVYRQISG VHKLQQTKFR QQPNAGKKQD HTIVDTVLMA PRSAKPALLK 900

LTEKQVEQRA FHDLKVAPGY YTLTADQDAR GMVEFQEGVE LVDVRVPLFI RPEDDDEKQL 960

LVEAIDVPAG TATLGRRLVN ITIIKEQARD SFEQPEFS VSRGDQVARI PVIRRVLDGG 1020

KSQVSYRTQD GTAQGNRDYI PVEGELLFQP GEAWKELQVK LLELQEVDSL LRGRQVRRFH 1080

VQLSNPKFGA HLGQPHSTTI IIRDPDELDR SFTSQMLSSQ PPPHGDLGAP QNPNAKAAGS 1140

RKIHFNWLPP SGKPMGYRVK YWIQGDSESE AHLLDSKVPS VELTNLYPYC DYEMKVCAYG 1200

AQGEGPYSSL VSCRTHQEVP SEPGRLAFNV VSSTVTQLSW AEPAETNGEI TAYEVCYGLV 1260

NDDNRPIGPM KKVLVDNPKN RMLLIENLRE SQPYRYTVKA RNGAGWGPER EAIINLATQP 1320

KRPMSIPIIP DIPIVDAQSG EDYDSFLMYS DDVLRSPSGS QRPSVSDDTE HLVNGRMDFA 1380

FPGSTNSLHR MTTTSAAAYG THLSPHVPHR VLSTSSTLTR DYNSLTRSEH SHSTTLPRDY 1440

STLTSVSSHD SRLTAGVPDT PTRLVFSALG PTSLRVSWQE PRCERPLQGY SVEYQLLNGG 1500

ELHRLNIPNP AQTSVWEDL LPNHSYVFRV RAQSQEGWGR EREGVITIES QVHPQSPLCP 1560

LPGSAFTLST PSAPGPLVFT ALSPDSLQLS WERPRRPNGD IVGYLVTCEM AQGGGPATAF 1620

RVDGDSPESR LTVPGLSENV PYKFKVQART TEGFGPEREG IITIESQDGG PFPQLGSRAG 1680

LFQHPLQSEY SSITTTHTSA TEPFLVDGPT LGAQHLEAGG SLTRHVTQEF VSRTLTTSGT 1740 LSTHMDQQFF QT

Seq ID NO: 562 DNA sequence

Nucleic Acid Accession ft: NM_013332.1

Coding sequence : 1..63

1 11 21 31 41 51 GCACGAGGGC GCTTTTGTCT CCGGTGAGTT TTGTGGCGGG AAGCTTCTGC GCTGGTGCTT 60

AGTAACCGAC TTTCCTCCGG ACTCCTGCAC GACCTGCTCC TACAGCCGGC GATCCACTCC 120

CGGCTGTTCC CCCGGAGGGT GCAGAGGCCT TTCAGAAGGA GAAGGCAGCT CTGTTTCTCT 180

GCAGAGGAGT AGGGTCCTTT CAGCCATGAA GCATGTGTTG AACCTCTACC TGTTAGGTGT 240

5 GGTACTGACC CTACTCTCCA TCTTCGTTAG AGTGATGGAG TCCCTAGAAG GCTTACTAGA 300

GAGCCCATCG CCTGGGACCT CCTGGACCAC CAGAAGCCAA CTAGCCAACA CAGAGCCCAC 360

CAAGGGCCTT CCAGACCATC CATCCAGAAG CATGTGATAA GACCTCCTTC CATACTGGCC 420

ATATTTTGGA ACACTGACCT AGACATGTCC AGATGGGAGT CCCATTCCTA GCAGACAAGC 480

TGAGCACCGT TGTAACCAGA GAACTATTAC TAGGCCTTGA AGAACCTGTC TAACTGGATG 540

10 CTCATTGCCT GGGCAAGGCC TGTTTAGGCC GGTTGCGGTG GCTCATGCCT GTAATCCTAG 600

CACTTTGGGA GGCTGAGGTG GGTGGATCAC CTGAGGTCAG GAGTTCGAGA CCAGCCTCGC 660

CAACATGGCG AAACCCCATC TCTACTAAAA ATACAAAAGT TAGCTGGGTG TGGTGGCAGA 720

GGCCTGTAAT CCCAGTTCCT TGGGAGGCTG AGGCGGGAGA ATTGCTTGAA CCCGGGGACG 780

GAGGTTGCAG TGAACCGAGA TCGCACTGCT GTACCCAGCC TGGGCCACAG TGCAAGACTC 840

15 CATCTCAAAA AAAAAAAGAA AAGAAAAAGC CTGTTTAATG CACAGGTGTG AGTGGATTGC 900

TTATGGCTAT GAGATAGGTT GATCTCGCCC TTACCCCGGG GTCTGGTGTA TGCTGTGCTT 960

TCCTCAGCAG TATGGCTCTG ACATCTCTTA GATGTCCCAA CTTCAGCTGT TGGGAGATGG 1020

TGATATTTTC AACCCTACTT CCTAAACATC TGTCTGGGGT TCCTTTAGTC TTGAATGTCT 1080

TATGCTCAAT TATTTGGTGT TGAGCCTCTC TTCCACAAGA GCTCCTCCAT GTTTGGATAG 1140

20 CAGTTGAAGA GGTTGTGTGG GTGGGCTGTT GGGAGTGAGG ATGGAGTGTT CAGTGCCCAT 1200

TTCTCATTTT ACATTTTAAA GTCGTTCCTC CAACATAGTG TGTATTGGTC TGAAGGGGGT 1260

GGTGGGATGC CAAAGCCTGC TCAAGTTATG GACATTGTGG CCACCATGTG GCTTAAATGA 1320

TTTTTTCTAA CTAATAAAGT GGAATATATA TTTCAAAAAA AAAAAAAAAA AA

25 Seq ID NO: 563 Protein sequence Protein Accession ft: NP_037464.1

1 11 21 31 41 51

J ,_nU M IKHVLNLYLL G IWLTLLSIF V IRVMESLEGL L IESPSPGTSW T ITRSQLANTE P ITKGLPDHPS 60 RSM

Seq ID NO: 564 DNA sequence Nucleic Acid Accession ft: NM_023915.1 35 Coding sequence: 250..1326

1 11 21 31 41 51

I I I I I I

GGCACGAGGG TTTCGTTTTC ATGCTTTACC AGAAAATCCA CTTCCCTGCC GACCTTAGTT 60

40 TCAAAGCTTA TTCTTAATTA GAGACAAGAA ACCTGTTTCA ACTTGAAGAC ACCGTATGAG 120

GTGAATGGAC AGCCAGCCAC CACAATGAAA GAAATCAAAC CAGGAATAAC CTATGCTGAA 180

CCCACGCCTC AATCGTCCCC AAGTGTTTCC TGACACGCAT CTTTGCTTAC AGTGCATCAC 240

AACTGAAGAA TGGGGTTCAA CTTGACGCTT GCAAAATTAC CAAATAACGA GCTGCACGGC 300

CAAGAGAGTC ACAATTCAGG CAACAGGAGC GACGGGCCAG GAAAGAACAC CACCCTTCAC 360

45 AATGAATTTG ACACAATTGT CTTGCCGGTG CTTTATCTCA TTATATTTGT GGCAAGCATC 420

TTGCTGAATG GTTTAGCAGT GTGGATCTTC TTCCACATTA GGAATAAAAC CAGCTTCATA 480

TTCTATCTCA AAAACATAGT GGTTGCAGAC CTCATAATGA CGCTGACATT TCCATTTCGA 540

ATAGTCCATG ATGCAGGATT TGGACCTTGG TACTTCAAGT TTATTCTCTG CAGATACACT 600

TCAGTTTTGT TTTATGCAAA CATGTATACT TCCATCGTGT TCCTTGGGCT GATAAGCATT 660

50 GATCGCTATC TGAAGGTGGT CAAGCCATTT GGGGACTCTC GGATGTACAG CATAACCTTC 720

ACGAAGGTTT TATCTGTTTG TGTTTGGGTG ATCATGGCTG TTTTGTCTTT GCCAAACATC 780

ATCCTGACAA ATGGTCAGCC AACAGAGGAC AATATCCATG ACTGCTCAAA ACTTAAAAGT 840

CCTTTGGGGG TCAAATGGCA TACGGCAGTC ACCTATGTGA ACAGCTGCTT GTTTGTGGCC 900

GTGCTGGTGA TTCTGATCGG ATGTTACATA GCCATATCCA GGTACATCCA CAAATCCAGC 960

55 AGGCAATTCA TAAGTCAGTC AAGCCGAAAG CGAAAACATA ACCAGAGCAT CAGGGTTGTT 1020

GTGGCTGTGT TTTTTACCTG CTTTCTACCA TATCACTTGT GCAGAATTCC TTTTACTTTT 1080

AGTCACTTAG ACAGGCTTTT AGATGAATCT GCACAAAAAA TCCTATATTA CTGCAAAGAA 1140

ATTACACTTT TCTTGTCTGC GTGTAATGTT TGCCTGGATC CAATAATTTA CTTTTTCATG 1200

TGTAGGTCAT TTTCAAGAAG GCTGTTCAAA AAATCAAATA TCAGAACCAG GAGTGAAAGC 1260

60 ATCAGATCAC TGCAAAGTGT GAGAAGATCG GAAGTTCGCA TATATTATGA TTACACTGAT 1320

GTGTAGGCCT TTTATTGTTT GTTGGAATCG ATATGTACAA AGTGTAAATA AATGTTTCTT 1380

TTCATTATCC TTAAAAAAAA AA

Seq ID NO: 565 Protein sequence 65 Protein Accession ft: NP 076404

1 11 21 31 41 51

I I I I I I

MGFNLTLAKL PNNELHGQES HNSGNRSDGP GKNTTLHNEF DTIVLPVLYL IIFVASILLN 60 0 GLAVWIFFHI RNKTSFIFYL KNIWADLIM TLTFPFRIVH DAGFGPWYFK FILCRYTSVL 120

FYANMYTSIV FLGLISIDRY LK KPFGDS RMYSITFTKV LSVCVWVIMA VLSLPNIILT 180

NGQPTEDNIH DCSKLKSPLG VKWHTAVTYV NSCLFVAVLV ILIGCYIAIS RYIHKSSRQF 240

ISQSSRKRKH NQSIRVWAV FFTCFLPYHL CRIPFTFSHL DRLLDESAQK ILYYCKEITL 300 FLSACNVCLD PIIYFFMCRS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR IYYDYTDV 5

Seq ID NO: 566 DNA sequence

Nucleic Acid Accession ft: NM_00536S.l

Coding sequence: 1..948 0 1 11 21 31 41 51

I I I I 1 I

ATGTCTCTCG AGCAGAGGAG TCCGCACTGC AAGCCTGATG AAGACCTTGA AGCCCAAGGA 60

GAGGACTTGG GCCTGATGGG TGCACAGGAA CCCACAGGCG AGGAGGAGGA GACTACCTCC 120

TCCTCTGACA GCAAGGAGGA GGAGGTGTCT GCTGCTGGGT CATCAAGTCC TCCCCAGAGT 180 5 CCTCAGGGAG GCGCTTCCTC CTCCATTTCC GTGTACTACA CTTTATGGAG CCAATTCGAT 240

GAGGGCTCCA GCAGTCAAGA AGAGGAAGAG CCAAGCTCCT CGGTCGACCC AGCTCAGCTG 300

GAGTTCATGT TCCAAGAAGC ACTGAAATTG AAGGTGGCTG AGTTGGTTCA TTTCCTGCTC 360 CACAAATATC GAGTCAAGGA GCCGGTCACA AAGGCAGAAA TGCTGGAGAG CGTCATCAAA 420

AATTACAAGC GCTACTTTCC TGTGATCTTC GGCAAAGCCT CCGAGTTCAT GCAGGTGATC 480

TTTGGCACTG ATGTGAAGGA GGTGGACCCC GCCGGCCACT CCTACATCCT TGTCACTGCT 540

CTTGGCCTCT CGTGCGATAG CATGCTGGGT GATGGTCATA GCATGCCCAA GGCCGCCCTC 600

CTGATCATTG TCCTGGGTGT GATCCTAACC AAAGACAACT GCGCCCCTGA AGAGGTTATC 660

TGGGAAGCGT TGAGTGTGAT GGGGGTGTAT GTTGGGAAGG AGCACATGTT CTACGGGGAG 720

CCCAGGAAGC TGCTCACCCA AGATTGGGTG CAGGAAAACT ACCTGGAGTA CCGGCAGGTG 780

CCCGGCAGTG ATCCTGCGCA CTACGAGTTC CTGTGGGGTT CCAAGGCCCA CGCTGAAACC 840

AGCTATGAGA AGGTCATAAA TTATTTGGTC ATGCTCAATG CAAGAGAGCC CATCTGCTAC 900 CCATCCCTTT ATGAAGAGGT TTTGGGAGAG GAGCAAGAGG GAGTCTGA

Seq ID NO: 567 Protein sequence Protein Accession ft: NP_005356.1

1 11 21 31 41 51

I I I I I I

MSLEQRSPHC KPDEDLEAQG EDLGLMGAQE PTGEEEETTS SSDSKEEEVS AAGSSSPPQS 60

PQGGASSSIS VYYTLWSQFD EGSSSQEEEE PSSSVDPAQL EFMFQEALKL KVAELVHFLL 120

HKYRVKEPVT KAEMLESVIK NYKRYFPVIF GKASEFMQVI FGTDVKEVDP AGHSYILVTA 180

LGLSCDSMLG DGHSMPKAAL LIIVLGVILT KDNCAPEEVI WEALSVMGVY VGKEHMFYGE 240

PRKLLTQDWV QENYLEYRQV PGSDPAHYEF LWGSKAHAET SYEKV1NYLV MLNAREPICY 300 PSLYEEVLGE EQEGV

Seq ID NO: 568 DNA sequence Nucleic Acid Accession ft: NM_014400 Coding sequence: 86..1126

1 11 21 31 41 51

I I I I I I

GGTTACTCAT CCTGGGCTCA GGTAAGAGGG CCCGAGCTCG GAGGCGGCAC ACCCAGGGGG 60

GACGCCAAGG GAGCAGGACG GAGCCATGGA CCCCGCCAGG AAAGCAGGTG CCCAGGCCAT 120

GATCTGGACT GCAGGCTGGC TGCTGCTGCT GCTGCTTCGC GGAGGAGCGC AGGCCCTGGA 180

GTGCTACAGC TGCGTGCAGA AAGCAGATGA CGGATGCTCC CCGAACAAGA TGAAGACAGT 240

GAAGTGCGCG CCGGGCGTGG ACGTCTGCAC CGAGGCCGTG GGGGCGGTGG AGACCATCCA 300

CGGACAATTC TCGCTGGGAG TGCSGGGTTG CGGTTCGGGA CTCCCCGGCA AGAATGACCG 360

CGGCCTGGAT CTTCACGGGC TTCTGGCGTT CATCCAGCTG CAGCAATGCG CTCAGGATCG 420

CTGCAACGCC AAGCTCAACC TCACCTCGCG GGCGCTCGAC CCGGCAGGTA ATGAGAGTGC 480

ATACCCGCCC AACGGCGTGG AGTGCTACAG CTGTGTGGGC CTGAGCCGGG AGGCGTGCCA 540

GGGTACATCG CCGCCGGTCG TGAGCTGCTA CAACGCCAGC GATCATGTCT ACAAGGGCTG 600

CTTCGACGGC AACGTCACCT TGACGGCAGC TAATGTGACT GTGTCCTTGC CTGTCCGGGG 660

CTGTGTCCAG GATGAATTCT GCACTCGGGA TGGAGTAACA GGCCCAGGGT TCACGCTCAG 720

TGGCTCCTGT TGCCAGGGGT CCCGCTGTAA CTCTGACCTC CGCAACAAGA CCTACTTCTC 780

CCCTCGAATC CCACCCCTTG TCCGGCTGCC CCCTCCAGAG CCCACGACTG TGGCCTCAAC 840

CACATCTGTC ACCACTTCTA CCTCGGCCCC AGTGAGACCC ACATCCACCA CCAAACCCAT 900

GCCAGCGCCA ACCAGTCAGA CTCCGAGACA GGGAGTAGAA CACGAGGCCT CCCGGGATGA 960

GGAGCCCAGG TTGACTGGAG GCGCCGCTGG CCACCAGGAC CGCAGCAATT CAGGGCAGTA 1020

TCCTGCAAAA GGGGGGCCCC AGCAGCCCCA TAATAAAGGC TGTGTGGCTC CCACAGCTGG 1080

ATTGGCAGCC CTTCTGTTGG CCGTGGCTGC TGGTGTCCTA CTGTGAGCTT CTCCACCTGG 1140

AAATTTCCCT CTCACCTACT TCTCTGGCCC TGGGTACCCC TCTTCTCATC ACTTCCTGTT 1200

CCCACCACTG GACTGGGCTG GCCCAGCCCC TGTTTTTCCA ACATTCCCCA GTATCCCCAG 1260

CTTCTGCTGC GCTGGTTTGC GGCTTTGGGA AATAAAATAC CGTTGTATAT ATTCTGGCAG 1320

GGGTGTTCTA GCTTTTTGAG GACAGCTCCT GTATCCTTCT CATCCTTGTC TCTCCGCTTG 1380

TCCTCTTGTG ATGTTAGGAC AGAGTGAGAG AAGTCAGCTG TCACGGGGAA GGTGAGAGAG 1440

AGGATGCTAA GCTTCCTACT CACTTTCTCC TAGCCAGCCT GGACTTTGGA GCGTGGGGTG 1500

GGTGGGACAA TGGCTCCCCA CTCTAAGCAC TGCCTCCCCT ACTCCCCGCA TCTTTGGGGA 1560

ATCGGTTCCC CATATGTCTT CCTTACTAGA CTGTGAGCTC CTCGAGGGCA GGGACCGTGC 1620

CTTATGTCTG TGTGTGATCA GTTTCTGGCA CATAAATGCC TCAATAAAGA TTTAATTACT 1680 TTGTATAGTG AAAAAAAA

Seq ID NO: 569 Protein sequence Protein Accession ft: NP_055215

1 11 21 31 41 51

I I I I I I

MDPARKAGAQ AMIWTAGWLL LLLLRGGAQA LECYSCVQKA DDGCSPNKMK TVKCAPGVDV 60

CTEAVGAVET IHGQFSLAVX GCGSGLPGKN DRGLDLHGLL AFIQLQQCAQ DRCNAKLNLT 120

SRALDPAGNE SAYPPNGVEC YSCVGLSREA CQGTSPPWS CYNASDHVYK GCFDGNVTLT 180

AANVTVSLPV RGCVQDEFCT RDGVTGPGFT LSGSCCQGSR CNSDLRNKTY FSPRIPPLVR 240

LPPPEPTTVA STTSVTTSTS APVRPTSTTK PMPAPTSQTP RQGVEHEASR DEEPRLTGGA 300 AGHQDRSNSG QYPAKGGPQQ PHNKGCVAPT AGLAALLLAV AAGVLL

Seq ID NO: 570 DNA sequence

Nucleic Acid Accession ft: NM_005329.1

Coding sequence: 1..1662

1 11 21 31 41 51

I I I I I I

ATGCCGGTGC AGCTGACGAC AGCCCTGCGT GTGGTGGGCA CCAGCCTGTT TGCCCTGGCA 60

GTGCTGGGTG GCATCCTGGC AGCCTATGTG ACGGGCTACC AGTTCATCCA CACGGAAAAG 120

CACTACCTGT CCTTCGGCCT GTACGGCGCC ATCCTGGGCC TGCACCTGCT CATTCAGAGC 180

CTTTTTGCCT TCCTGGAGCA CCGGCGCATG CGACGTGCCG GCCAGGCCCT GAAGCTGCCC 240

TCCCCGCGGC GGGGCTCGGT GGCACTGTGC ATTGCCGCGT ACCAGGAGGA CCCTGACTAC 300

TTGCGCAAGT GCCTGCGCTC GGCCCAGCGC ATCTCCTTCC CTGACCTCAA GGTGGTCATG 360

GTGGTGGATG GCAACCGCCA GGAGGACGCC TACATGCTGG ACATCTTCCA CGAGGTGCTG 420

GGCGGCACCG AGCAGGCCGG CTTCTTTGTG TGGCGCAGCA ACTTCCATGA GGCAGGCGAG 480

GGTGAGACGG AGGCCAGCCT GCAGGAGGGC ATGGACCGTG TGCGGGATGT GGTGCGGGCC 540

AGCACCTTCT CGTGCATCAT GCAGAAGTGG GGAGGCAAGC GCGAGGTCAT GTACACGGCC 600 TTCAAGGCCC TCGGCGATTC GGTGGACTAC ATCCAGGTGT GCGACTCTGA CACTGTGCTG 660 GATCCAGCCT GCACCATCGA GATGCTTCGA GTCCTGGAGG AGGATCCCCA AGTAGGGGGA 720 GTCGGGGGAG ATGTCCAGAT CCTCAACAAG TACGACTCAT GGATTTCCTT CCTGAGCAGC 780 GTGCGGTACT GGATGGCCTT CAACGTGGAG CGGGCCTGCC AGTCCTACTT TGGCTGTGTG 840 CAGTGTATTA GTGGGCCCTT GGGCATGTAC CGCAACAGCC TCCTCCAGCA GTTCCTGGAG 900 GACTGGTACC ATCAGAAGTT CCTAGGCAGC AAGTGCAGCT TCGGGGATGA CCGGCACCTC 960 ACCAACCGAG TCCTGAGCCT TGGCTACCGA ACTAAGTATA CCGCGCGCTC CAAGTGCCTC 1020 ACAGAGACCC CCACTAAGTA CCTCCGGTGG CTCAACCAGC AAACCCGCTG GAGCAAGTCT 1080 TACTTCCGGG AGTGGCTCTA CAACTCTCTG TGGTTCCATA AGCACCACCT CTGGATGACC 1140 TACGAGTCAG TGGTCACGGG TTTCTTCCCC TTCTTCCTCA TTGCCACGGT TATACAGCTT 1200 TTCTACCGGG GCCGCATCTG GAACATTCTC CTCTTCCTGC TGACGGTGCA GCTGGTGGGC 1260 ATTATCAAGG CCACCTACGC CTGCTTCCTT CGGGGCAATG CAGAGATGAT CTTCATGTCC 1320 CTCTACTCCC TCCTCTATAT GTCCAGCCTT CTGCCGGCCA AGATCTTTGC CATTGCTACC 1380 ATCAACAAAT CTGGCTGGGG CACCTCTGGC CGAAAAACCA TTGTGGTGAA CTTCATTGGC 1440 CTCATTCCTG TGTCCATCTG GGTGGCAGTT CTCCTGGGAG GGCTGGCCTA CACAGCTTAT 1500 TGCCAGGACC TGTTCAGTGA GACAGAGCTA GCCTTCCTTG TCTCTGGGGC TATACTGTAT 1560 GGCTGCTACT GGGTGGCCCT CCTCATGCTA TATCTGGCCA TCATCGCCCG GCGATGTGGG 1620 AAGAAGCCGG AGCAGTACAG CTTGGCTTTT GCTGAGGTGT GA

Seq ID NO: 571 Protein sequence Protein Accession ft: NP 005320.1

11 21 31 41 51

MPVQLTTALR W IGTSLFALA V ILGGILAAYV T IGYQFIHTEK H IYLSFGLYGA I ILGLHLLIQS 60 LFAFLEHRRM RRAGQALKLP SPRRGSVALC IAAYQEDPDY LRKCLRSAQR ISFPDLKWM 120 WDGNRQEDA YMLDIFHEVL GGTEQAGFFV WRSNFHEAGE GETEASLQEG MDRVRDWRA 180 STFSCIMQKW GGKREVMYTA FKALGDSVDY IQVCDSDTVL DPACTIEMLR VLEEDPQVGG 240 VGGDVQILNK YDSWISFLSS VRYWMAFNVE RACQSYFGCV QCISGPLGMY RNSLLQQFLE 300 DWYHQKFLGS KCSFGDDRHL TNRVLSLGYR TKYTARSKCL TETPTKYLRW LNQQTRWSKS 360 YPREWLYNSL WFHKHHLWMT YESWTGFFP FFLIATVIQL FYRGRIWNIL LFLLTVQLVG 420 IIKATYACFL RGNAEMIFMS LYSLLYMSSL LPAKIFAIAT INKSGWGTSG RKTIWNFIG 480 LIPVSIWVAV LLGGLAYTAY CQDLFSETEL AFLVSGAILY GCYWVALLML YLAIIARRCG 540 KKPEQYSLAF AEV

Seq ID NO: 572 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 148-7095

11 21 31 41 51

CACACATACG CACGCACGAT CTCACTTCGA TCTATACACT GGAGGATTAA AACAAACAAA 60 CAAAAAAAAC ATTTCCTTCG CTCCCCCTCC CTCTCCACTC TGAGAAGCAG AGGAGCCGCA 120 CGGCGAGGGG CCGCAGACCG TCTGGAAATG CGAATCCTAA AGCGTTTCCT CGCTTGCATT 180 CAGCTCCTCT GTGTTTGCCG CCTGGATTGG GCTAATGGAT ACTACAGACA ACAGAGAAAA 240 CTTGTTGAAG AGATTGGCTG GTCCTATACA GGAGCACTGA ATCAAAAAAA TTGGGGAAAG 300 AAATATCCAA CATGTAATAG CCCAAAACAA TCTCCTATCA ATATTGATGA AGATCTTACA 360 CAAGTAAATG TGAATCTTAA GAAACTTAAA TTTCAGGGTT GGGATAAAAC ATCATTGGAA 420 AACACATTCA TTCATAACAC TGGGAAAACA GTGGAAATTA ATCTCACTAA TGACTACCGT 480 GTCAGCGGAG GAGTTTCAGA AATGGTGTTT AAAGCAAGCA AGATAACTTT TCACTGGGGA 540 AAATGCAATA TGTCATCTGA TGGATCAGAG CATAGTTTAG AAGGACAAAA ATTTCCACTT 600 GAGATGCAAA TCTACTGCTT TGATGCGGAC CGATTTTCAA GTTTTGAGGA AGCAGTCAAA 660 GGAAAAGGGA AGTTAAGAGC TTTATCCATT TTGTTTGAGG TTGGGACAGA AGAAAATTTG 720 GATTTCAAAG CGATTATTGA TGGAGTCGAA AGTGTTAGTC GTTTTGGGAA GCAGGCTGCT 780 TTAGATCCAT TCATACTGTT GAACCTTCTG CCAAACTCAA CTGACAAGTA TTACATTTAC 840 AATGGCTCAT TGACATCTCC TCCCTGCACA GACACAGTTG ACTGGATTGT TTTTAAAGAT 900 ACAGTTAGCA TCTCTGAAAG CCAGTTGGCT GTTTTTTGTG AAGTTCTTAC AATGCAACAA 960 TCTGGTTATG TCATGCTGAT GGACTACTTA CAAAACAATT TTCGAGAGCA ACAGTACAAG 1020 TTCTCTAGAC AGGTGTTTTC CTCATACACT GGAAAGGAAG AGATTCATGA AGCAGTTTGT 1080 AGTTCAGAAC CAGAAAATGT TCAGGCTGAC CCAGAGAATT ATACCAGCCT TCTTGTTACA 1140 TGGGAAAGAC CTCGAGTCGT TTATGATACC ATGATTGAGA AGTTTGCAGT TTTGTACCAG 1200 CAGTTGGATG GAGAGGACCA AACCAAGCAT GAATTTTTGA CAGATGGCTA TCAAGACTTG 1260 GGTGCTATTC TCAATAATTT GCTACCCAAT ATGAGTTATG TTCTTCAGAT AGTAGCCATA 1320 TGCACTAATG GCTTATATGG AAAATACAGC GACCAACTGA TTGTCGACAT GCCTACTGAT 1380 AATCCTGAAC TTGATCTTTT CCCTGAATTA ATTGGAACTG AAGAAATAAT CAAGGAGGAG 1440 GAAGAGGGAA AAGACATTGA AGAAGGCGCT ATTGTGAATC CTGGTAGAGA CAGTGCTACA 1500 AACCAAATCA GGAAAAAGGA ACCCCAGATT TCTACCACAA CACACTACAA TCGCATAGGG 1560 ACGAAATACA ATGAAGCCAA GACTAACCGA TCCCCAACAA GAGGAAGTGA ATTCTCTGGA 1620 AAGGGTGATG TTCCCAATAC ATCTTTAAAT TCCACTTCCC AACCAGTCAC TAAATTAGCC 1680 ACAGAAAAAG ATATTTCCTT GACTTCTCAG ACTGTGACTG AACTGCCACC TCACACTGTG 1740 GAAGGTACTT CAGCCTCTTT AAATGATGGC TCTAAAACTG TTCTTAGATC TCCACATATG 1800 AACTTGTCGG GGACTGCAGA ATCCTTAAAT ACAGTTTCTA TAACAGAATA TGAGGAGGAG 1860 AGTTTATTGA CCAGTTTCAA GCTTGATACT GGAGCTGAAG ATTCTTCAGG CTCCAGTCCC 1920 GCAACTTCTG CTATCCCATT CATCTCTGAG AACATATCCC AAGGGTATAT ATTTTCCTCC 1980 GAAAACCCAG AGACAATAAC ATATGATGTC CTTATACCAG AATCTGCTAG AAATGCTTCC 2040 GAAGATTCAA CTTCATCAGG TTCAGAAGAA TCACTAAAGG ATCCTTCTAT GGAGGGAAAT 2100 GTGTGGTTTC CTAGCTCTAC AGACATAACA GCACAGCCCG ATGTTGGATC AGGCAGAGAG 2160 AGCTTTCTCC AGACTAATTA CACTGAGATA CGTGTTGATG AATCTGAGAA GACAACCAAG 2220 TCCTTTTCTG CAGGCCCAGT GATGTCACAG GGTCCCTCAG TTACAGATCT GGAAATGCCA 2280

CATTATTCTA CCTTTGCCTA CTTCCCAACT GAGGTAACAC CTCATGCTTT TACCCCATCC 2340 TCCAGACAAC AGGATTTGGT CTCCACGGTC AACGTGGTAT ACTCGCAGAC AACCCAACCG 2400 GTATACAATG GTGAGACACC TCTTCAACCT TCCTACAGTA GTGAAGTCTT TCCTCTAGTC 2460 ACCCCTTTGT TGCTTGACAA TCAGATCCTC AACACTACCC CTGCTGCTTC AAGTAGTGAT 2520 TCGGCCTTGC ATGCTACGCC TGTATTTCCC AGTGTCGATG TGTCATTTGA ATCCATCCTG 2580 TCTTCCTATG ATGGTGCACC TTTGCTTCCA TTTTCCTCTG CTTCCTTCAG TAGTGAATTG 2640 TTTCGCCATC TGCATACAGT TTCTCAAATC CTTCCACAAG TTACTTCAGC TACCGAGAGT 2700 GATAAGGTGC CCTTGCATGC TTCTCTGCCA GTGGCTGGGG GTGATTTGCT ATTAGAGCCC 2760 AGCCTTGCTC AGTATTCTGA TGTGCTGTCC ACTACTCATG CTGCTTCAGA GACGCTGGAA 2820

TTTGGTAGTβ AATCTGGTGT TCTTTATAAA ACGCTTATGT TTTCTCAAGT TGAACCACCC 2880

AGCAGTGATG CCATGATGCA TGCACGTTCT TCAGGGCCTG AACCTTCTTA TGCCTTGTCT 2940

GATAATGAGG GCTCCCAACA CATCTTCACT GTTTCTTACA GTTCTGCAAT ACCTGTGCAT 3000

GATTCTGTGG GTGTAACTTA TCAGGGTTCC TTATTTAGCG GCCCTAGCCA TATACCAATA 3060

CCTAAGTCTT CGTTAATAAC CCCAACTGCA TCATTACTGC AGCCTACTCA TGCCCTCTCT 3120

GGTGATGGGG AATGGTCTGG AGCCTCTTCT GATAGTGAAT TTCTTTTACC TGACACAGAT 3180

GGGCTGACAG CCCTTAACAT TTCTTCACCT GTTTCTGTAG CTGAATTTAC ATATACAACA 3240

TCTGTGTTTG GTGATGATAA TAAGGCGCTT TCTAAAAGTG AAATAATATA TGGAAATGAG 3300

ACTGAACTGC AAATTCCTTC TTTCAATGAG ATGGTTTACC CTTCTGAAAG CACAGTCATG 3360

CCCAACATGT ATGATAATGT AAATAAGTTG AATGCGTCTT TACAAGAAAC CTCTGTTTCC 3420

ATTTCTAGCA CCAAGGGCAT GTTTCCAGGG TCCCTTGCTC ATACCACCAC TAAGGTTTTT 3480

GATCATGAGA TTAGTCAAGT TCCAGAAAAT AACTTTTCAG TTCAACCTAC ACATACTGTC 3540

TCTCAAGCAT CTGGTGACAC TTCGCTTAAA CCTGTGCTTA GTGCAAACTC AGAGCCAGCA 3600

TCCTCTGACC CTGCTTCTAG TGAAATGTTA TCTCCTTCAA CTCAGCTCTT ATTTTATGAG 3660

ACCTCAGCTT CTTTTAGTAC TGAAGTATTG CTACAACCTT CCTTTCAGGC TTCTGATGTT 3720

GACACCTTGC TTAAAACTGT TCTTCCAGCT GTGCCCAGTG ATCCAATATT GGTTGAAACC 3780

CCCAAAGTTG ATAAAATTAG TTCTACAATG TTGCATCTCA TTGTATCAAA TTCTGCTTCA 3840

AGTGAAAACA TGCTGCACTC TACATCTGTA GCAGTTTTTG ATGTGTCGCC TACTTCTCAT 3900

ATGCACTCTG CTTCACTTCA AGGTTTGACC ATTTCCTATG CAAGTGAGAA ATATGAACCA 3960

GTTTTGTTAA AAAGTGAAAG TTCCCACCAA GTGGTACCTT CTTTGTACAG TAATGATGAG 4020

TTGTTCCAAA CGGCCAATTT GGAGATTAAC CAGGCCCATC CCCCAAAAGG AAGGCATGTA 4080

TTTGCTACAC CTGTTTTATC AATTGATGAA CCATTAAATA CACTAATAAA TAAGCTTATA 4140

CATTCCGATG AAATTTTAAC CTCCACCAAA AGTTCTGTTA CTGGTAAGGT ATTTGCTGGT 4200

ATTCCAACAG TTGCTTCTGA TACATTTGTA TCTACTGATC ATTCTGTTCC TATAGGAAAT 4260

GGGCATGTTG CCATTACAGC TGTTTCTCCC CACAGAGATG GTTCTGTAAC CTCAACAAAG 4320

TTGCTGTTTC CTTCTAAGGC AACTTCTGAG CTGAGTCATA GTGCCAAATC TGATGCCGGT 4380

TTAGTGGGTG GTGGTGAAGA TGGTGACACT GATGATGATG GTGATGATGA TGATGATGAC 4440

AGAGGTAGTG ATGGCTTATC CATTCATAAG TGTATGTCAT GCTCATCCTA TAGAGAATCA 4500

CAGGAAAAGG TAATGAATGA TTCAGACACC CACGAAAACA GTCTTATGGA TCAGAATAAT 4560

CCAATCTCAT ACTCACTATC TGAGAATTCT GAAGAAGATA ATAGAGTCAC AAGTGTATCC 4620

TCAGACAGTC AAACTGGTAT GGACAGAAGT CCTGGTAAAT CACCATCAGC AAATGGGCTA 4680

TCCCAAAAGC ACAATGATGG AAAAGAGGAA AATGACATTC AGACTGGTAG TGCTCTGCTT 4740

CCTCTCAGCC CTGAATCTAA AGCATGGGCA GTTCTGACAA GTGATGAAGA AAGTGGATCA 4800

GGGCAAGGTA CCTCAGATAG CCTTAATGAG AATGAGACTT CCACAGATTT CAGTTTTGCA 4860

GACACTAATG AAAAAGATGC TGATGGGATC CTGGCAGCAG GTGACTCAGA AATAACTCCT 4920

GGATTCCCAC AGTCCCCAAC ATCATCTGTT ACTAGCGAGA ACTCAGAAGT GTTCCACGTT 4980

TCAGAGGCAG AGGCCAGTAA TAGTAGCCAT GAGTCTCGTA TTGGTCTAGC TGAGGGGTTG 5040

GAATCCGAGA AGAAGGCAGT TATACCCCTT GTGATCGTGT CAGCCCTGAC TTTTATCTGT 5100

CTAGTGGTTC TTGTGGGTAT TCTCATCTAC TGGAGGAAAT GCTTCCAGAC TGCACACTTT 5160

TACTTAGAGG ACAGTACATC CCCTAGAGTT ATATCCACAC CTCCAACACC TATCTTTCCA 5220

ATTTCAGATG ATGTCGGAGC AATTCCAATA AAGCACTTTC CAAAGCATGT TGCAGATTTA 5280

CATGCAAGTA GTGGGTTTAC TGAAGAATTT GAGACACTGA AAGAGTTTTA CCAGGAAGTG 5340

CAGAGCTGTA CTGTTGACTT AGGTATTACA GCAGACAGCT CCAACCACCC AGACAACAAG 5 00

CACAAGAATC GATACATAAA TATCGTTGCC TATGATCATA GCAGGGTTAA GCTAGCACAG 5460

CTTGCTGAAA AGGATGGCAA ACTGACTGAT TATATCAATG CCAATTATGT TGATGGCTAC 5520

AACAGACCAA AAGCTTATAT TGCTGCCCAA GGCCCACTGA AATCCACAGC TGAAGATTTC 5580

TGGAGAATGA TATGGGAACA TAATGTGGAA GTTATTGTCA TGATAACAAA CCTCGTGGAG 5640

AAAGGAAGGA GAAAATGTGA TCAGTACTGG CCTGCCGATG GGAGTGAGGA GTACGGGAAC 5700

TTTCTGGTCA CTCAGAAGAG TGTGCAAGTG CTTGCCTATT ATACTGTGAG GAATTTTACT 5760

CTAAGAAACA CAAAAATAAA AAAGGGCTCC CAGAAAGGAA GACCCAGTGG ACGTGTGGTC 5820

ACACAGTATC ACTACACGCA GTGGCCTGAC ATGGGAGTAC CAGAGTACTC CCTGCCAGTG 5880

CTGACCTTTG TGAGAAAGGC AGCCTATGCC AAGCGCCATG CAGTGGGGCC TGTTGTCGTC 5940

CACTGCAGTG CTGGAGTTGG AAGAACAGGC ACATATATTG TGCTAGACAG TATGTTGCAG 6000

CAGATTCAAC ACGAAGGAAC TGTCAACATA TTTGGCTTCT TAAAACACAT CCGTTCACAA 6060

AGAAATTATT TGGTACAAAC TGAGGAGCAA TATGTCTTCA TTCATGATAC ACTGGTTGAG 6120

GCCATACTTA GTAAAGAAAC TGAGGTGCTG GACAGTCATA TTCATGCCTA TGTTAATGCA 6180

CTCCTCATTC CTGGACCAGC AGGCAAAACA AAGCTAGAGA AACAATTCCA GCTCCTGAGC 6240

CAGTCAAATA TACAGCAGAG TGACTATTCT GCAGCCCTAA AGCAATGCAA CAGGGAAAAG 6300

AATCGAACTT CTTCTATCAT CCCTGTGGAA AGATCAAGGG TTGGCATTTC ATCCCTGAGT 6360

GGAGAAGGCA CAGACTACAT CAATGCCTCC TATATCATGG GCTATTACCA GAGCAATGAA 6420

TTCATCATTA CCCAGCACCC TCTCCTTCAT ACCATCAAGG ATTTCTGGAG GATGATATGG 6480

GACCATAATG CCCAACTGGT GGTTATGATT CCTGATGGCC AAAACATGGC AGAAGATGAA 6540

TTTGTTTACT GGCCAAATAA AGATGAGCCT ATAAATTGTG AGAGCTTTAA GGTCACTCTT 6600

ATGGCTGAAG AACACAAATG TCTATCTAAT GAGGAAAAAC TTATAATTCA GGACTTTATC 6660

TTAGAAGCTA CACAGGATGA TTATGTACTT GAAGTGAGGC ACTTTCAGTG TCCTAAATGG 6720

CCAAATCCAG ATAGCCCCAT TAGTAAAACT TTTGAACTTA TAAGTGTTAT AAAAGAAGAA 6780

GCTGCCAATA GGGATGGGCC TATGATTGTT CATGATGAGC ATGGAGGAGT GACGGCAGGA 6840

ACTTTCTGTG CTCTGACAAC CCTTATGCAC CAACTAGAAA AAGAAAATTC CGTGGATGTT 6900

TACCAGGTAG CCAAGATGAT CAATCTGATG AGGCCAGGAG TCTTTGCTGA CATTGAGCAG 6g60

TATCAGTTTC TCTACAAAGT GATCCTCAGC CTTGTGAGCA CAAGGCAGGA AGAGAATCCA 7020

TCCACCTCTC TGGACAGTAA TGGTGCAGCA TTGCCTGATG GAAATATAGC TGAGAGCTTA 7080

GAGTCTTTAG TTTAACACAG AAAGGGGTGG GGGGACTCAC ATCTGAGCAT TGTTTTCCTC 7140

TTCCTAAAAT TAGGCAGGAA AATCAGTCTA GTTCTGTTAT CTGTTGATTT CCCATCACCT 7200

GACAGTAACT TTCATGACAT AGGATTCTGC CGCCAAATTT ATATCATTAA CAATGTGTGC 7260

CTTTTTGCAA GACTTGTAAT TTACTTATTA TGTTTGAACT AAAATGATTG AATTTTACAG 7320

TATTTCTAAG AATGGAATTG TGGTATTTTT TTCTGTATTG ATTTTAACAG AAAATTTCAA 7380

TTTATAGAGG TTAGGAATTC CAAACTACAG AAAATGTTTG TTTTTAGTGT CAAATTTTTA 7440

GCTGTATTTG TAGCAATTAT CAGGTTTGCT AGAAATATAA CTTTTAATAC AGTAGCCTGT 7500 AAATAAAACA CTCTTCCATA TGATATTCAA CATTTTACAA CTGCAGTATT CACCTAAAGT 7560

AGAAATAATC TGTTACTTAT TGTAAATACT GCCCTAGTGT CTCCATGGAC CAAATTTATA 7620

TTTATAATTG TAGATTTTTA TATTTTACTA CTGAGTCAAG TTTTCTAGTT CTGTGTAATT 7680

GTTTAGTTTA ATGACGTAGT TCATTAGCTG GTCTTACTCT ACCAGTTTTC TGACATTGTA 7740

TTGTGTTACC TAAGTCATTA ACTTTGTTTC AGCATGTAAT TTTAACTTTT GTGGAAAATA 7800

GAAATACCTT CATTTTGAAA GAAGTTTTTA TGAGAATAAC ACCTTACCAA ACATTGTTCA 7860

AATGGTTTTT ATCCAAGGAA TTGCAAAAAT AAATATAAAT ATTGCCATTA AAAAAAAAAA 7 20 AAAAAAAAAA AAAAAAAAAA AAAA Seq ID NO: 573 Protein sequence: Protein Accession ft: Eos sequence 1 11 21 31 41 51

1 I I I I I

MRILKRFLAC IQLLCVCRLD WANGYYRQQR KLVEEIGWSY TGALNQKNWG KKYPTCNSPK 60

QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 120

FKASKITFHW GKCNMSSDGS EHSLEGQKFP LEMQIYCFDA DRFSSFEEAV KGKGKLRALS 180 ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 240

TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 300

TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPRWYD TMIEKFAVLY QQLDGEDQTK 360

HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY SDQLIVDMPT DNPELDLPPE 420

LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 480 RSPTRGSEFS GKGDVPNTSL NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND 540

GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSPKLD TGAEDSSGSS PATSAIPFIS 600

ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG NVWFPSSTDI 660

TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 720

TEVTPHAPTP SSRQQDLVST VNWYSQTTQ PVYNGETPLQ PSYSSEVFPL VTPLLLDNQI 780 LNTTPAASSS DSALHATPVF PSVDVSFESI LSSYDGAPLL PFSSASFSSE LFRHLHTVSQ 840

ILPQVTSATE SDKVPLHASL PVAGGDLLLE PSLAQYSDVL STTHAASETL EFGSESGVLY 900

KTLMFSQVEP PSSDAMMHAR SSGPEPSYAL SDNEGSQHIF TVSYSSAIPV HDSVGVTYQG 960

SLFSGPSHIP IPKSSLITPT ASLLQPTHAL SGDGEWSGAS SDSEFLLPDT DGLTALNISS 1020

PVSVAEFTYT TSVFGDDNKA LSKSEIIYGN ETELQIPSFN EMVYPSESTV MPNMYDNVNK 1080 LNASLQETSV SISSTKGMFP GSLAHTTTKV FDHEISQVPE NNFSVQPTHT VSQASGDTSL 1140

KPVLSANSEP ASSDPASSEM LSPSTQLLFY ETSASFSTEV LLQPSFQASD VDTLLKTVLP 1200

AVPSDPILVE TPKVDKISST MLHLIVSNSA SSENMLHSTS VPVFDVSPTS HMHSASLQGL 1260

TISYASEKYE PVLLKSESSH QWPSLYSND ELFQTANLEI NQAHPPKGRH VFATPVLSID 1320

EPLNTLINKL IHSDEILTST KSSVTGKVFA GIPTVASDTF VSTDHSVPIG NGHVAITAVS 1380 PHRDGSVTST KLLFPSKATS ELSHSAKSDA GLVGGGEDGD TDDDGDDDDD DRGSDGLSIH 1440

KCMSCSSYRE SQEKVMNDSD THENSLMDQN NPISYSLSEN SEEDNRVTSV SSDSQTGMDR 1500

SPGKSPSANG LSQKHNDGKE ENDIQTGSAL LPLSPESKAW AVLTSDEESG SGQGTSDSLN 1560

ENETSTDFSF ADTNEKDADG ILAAGDSEIT PGFPQSPTSS VTSENSEVFH VSEAEASNSS 1620

HESRIGLAEG LESEKKAVIP LVIVSALTFI CLWLVGILI YWRKCFQTAH FYLEDSTSPR 1680 VISTPPTPIF PISDDVGAIP IKHFPKHVAD LHASSGFTEE FETLKEFYQE VQSCTVDLGI 1740

TADSSNHPDN KHKNRYINIV AYDHSRVKLA QLAEKDGKLT DYINANYVDG YNRPKAYIAA 1800

QGPLKSTAED FWRMIWEHNV EVIVMITNLV EKGRRKCDQY WPADGSEEYG NFLVTQKSVQ 1860

VLAYYTVRNF TLRNTKIKKG SQKGRPSGRV VTQYHYTQWP DMGVPEYSLP VLTFVRKAAY 1920

AKRHAVGPW VHCSAGVGRT GTYIVLDSML QQIQHEGTVN IFGFLKHIRS QRNYLVQTEE 1980 QYVFIHDTLV EAILSKETEV LDSHIHAYVN ALLIPGPAGK TKLEKQFQLL SQSNIQQSDY 2040

SAALKQCNRE KNRTSSIIPV ERSRVGISSL SGEGTDYINA SYIMGYYQSN EFIITQHPLL 2100

HTIKDFWRMI WDHNAQL M IPDGQNMAED EFVYWPNKDE PINCESFKVT LMAEEHKCLS 2160

NEEKLIIQDF ILEATQDDYV LEVRHFQCPK WPNPDSPISK TFELISVIKE EAANRDGPMI 2220

VHDEHGGVTA GTFCALTTLM HQLEKENSVD VYQVAKMINL MRPGVFADIE QYQFLYKVIL 2280 SLVSTRQEEN PSTSLDSNGA ALPDGNIAES LESLV

Seq ID NO: 574 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 148-4518

1 11 21 31 41 51

C IACACATACG CIACGCACGAT CITCACTTCGA TICTATACACT GIGAGGATTAA AIACAAACAAA 60

CAAAAAAAAC ATTTCCTTCG CTCCCCCTCC CTCTCCACTC TGAGAAGCAG AGGAGCCGCA 120

CGGCGAGGGG CCGCAGACCG TCTGGAAATG CGAATCCTAA AGCGTTTCCT CGCTTGCATT 180

CAGCTCCTCT GTGTTTGCCG CCTGGATTGG GCTAATGGAT ACTACAGACA ACAGAGAAAA 240

CTTGTTGAAG AGATTGGCTG GTCCTATACA GGAGCACTGA ATCAAAAAAA TTGGGGAAAG 300

AAATATCCAA CATGTAATAG CCCAAAACAA TCTCCTATCA ATATTGATGA AGATCTTACA 360

CAAGTAAATG TGAATCTTAA GAAACTTAAA TTTCAGGGTT GGGATAAAAC ATCATTGGAA 420

AACACATTCA TTCATAACAC TGGGAAAACA GTGGAAATTA ATCTCACTAA TGACTACCGT 480

GTCAGCGGAG GAGTTTCAGA AATGGTGTTT AAAGCAAGCA AGATAACTTT TCACTGGGGA 540

AAATGCAATA TGTCATCTGA TGGATCAGAG CATAGTTTAG AAGGACAAAA ATTTCCACTT 600

GAGATGCAAA TCTACTGCTT TGATGCGGAC CGATTTTCAA GTTTTGAGGA AGCAGTCAAA 660

GGAAAAGGGA AGTTAAGAGC TTTATCCATT TTGTTTGAGG TTGGGACAGA AGAAAATTTG 720

GATTTCAAAG CGATTATTGA TGGAGTCGAA AGTGTTAGTC GTTTTGGGAA GCAGGCTGCT 780

TTAGATCCAT TCATACTGTT GAACCTTCTG CCAAACTCAA CTGACAAGTA TTACATTTAC 840

AATGGCTCAT TGACATCTCC TCCCTGCACA GACACAGTTG ACTGGATTGT TTTTAAAGAT 900

ACAGTTAGCA TCTCTGAAAG CCAGTTGGCT GTTTTTTGTG AAGTTCTTAC AATGCAACAA 960

TCTGGTTATG TCATGCTGAT GGACTACTTA CAAAACAATT TTCGAGAGCA ACAGTACAAG 1020

TTCTCTAGAC AGGTGTTTTC CTCATACACT GGAAAGGAAG AGATTCATGA AGCAGTTTGT 1080

AGTTCAGAAC CAGAAAATGT TCAGGCTGAC CCAGAGAATT ATACCAGCCT TCTTGTTACA 1140

TGGGAAAGAC CTCGAGTCGT TTATGATACC ATGATTGAGA AGTTTGCAGT TTTGTACCAG 1200

CAGTTGGATG GAGAGGACCA AACCAAGCAT GAATTTTTGA CAGATGGCTA TCAAGACTTG 1260

GGTGCTATTC TCAATAATTT GCTACCCAAT ATGAGTTATG TTCTTCAGAT AGTAGCCATA 1320

TGCACTAATG GCTTATATGG AAAATACAGC GACCAACTGA TTGTCGACAT GCCTACTGAT 1380

AATCCTGAAC TTGATCTTTT CCCTGAATTA ATTGGAACTG AAGAAATAAT CAAGGAGGAG 1440

GAAGAGGGAA AAGACATTGA AGAAGGCGCT ATTGTGAATC CTGGTAGAGA CAGTGCTACA 1500

AACCAAATCA GGAAAAAGGA ACCCCAGATT TCTACCACAA CACACTACAA TCGCATAGGG 1560

ACGAAATACA ATGAAGCCAA GACTAACCGA TCCCCAACAA GAGGAAGTGA ATTCTCTGGA 1620

AAGGGTGATG TTCCCAATAC ATCTTTAAAT TCCACTTCCC AACCAGTCAC TAAATTAGCC 1680

ACAGAAAAAG ATATTTCCTT GACTTCTCAG ACTGTGACTG AACTGCCACC TCACACTGTG 1740

GAAGGTACTT CAGCCTCTTT AAATGATGGC TCTAAAACTG TTCTTAGATC TCCACATATG 1800

AACTTGTCGG GGACTGCAGA ATCCTTAAAT ACAGTTTCTA TAACAGAATA TGAGGAGGAG 1860

AGTTTATTGA CCAGTTTCAA GCTTGATACT GGAGCTGAAG ATTCTTCAGG CTCCAGTCCC 1920

GCAACTTCTG CTATCCCATT CATCTCTGAG AACATATCCC AAGGGTATAT ATTTTCCTCC 1980

GAAAACCCAG AGACAATAAC ATATGATGTC CTTATACCAG AATCTGCTAG AAATGCTTCC 2040

GAAGATTCAA CTTCATCAGG TTCAGAAGAA TCACTAAAGG ATCCTTCTAT GGAGGGAAAT 2100 GTGTGGTTTC CTAGCTCTAC AGACATAACA GCACAGCCCG ATGTTGGATC AGGCAGAGAG 2160

AGCTTTCTCC AGACTAATTA CACTGAGATA CGTGTTGATG AATCTGAGAA GACAACCAAG 2220

TCCTTTTCTG CAGGCCCAGT GATGTCACAG GGTCCCTCAG TTACAGATCT GGAAATGCCA 2280

CATTATTCTA CCTTTGCCTA CTTCCCAACT GAGGTAACAC CTCATGCTTT TACCCCATCC 2340

TCCAGACAAC AGGATTTGGT CTCCACGGTC AACGTGGTAT ACTCGCAGAC AACCCAACCG 2400

GTATACAATG CAGAGGCCAG TAATAGTAGC CATGAGTCTC GTATTGGTCT AGCTGAGGGG 2460

TTGGAATCCG AGAAGAAGGC AGTTATACCC CTTGTGATCG TGTCAGCCCT GACTTTTATC 2520

TGTCTAGTGG TTCTTGTGGG TATTCTCATC TACTGGAGGA AATGCTTCCA GACTGCACAC 2580

TTTTACTTAG AGGACAGTAC ATCCCCTAGA GTTATATCCA CACCTCCAAC ACCTATCTTT 2640

CCAATTTCAG ATGATGTCGG AGCAATTCCA ATAAAGCACT TTCCAAAGCA TGTTGCAGAT 2700

TTACATGCAA GTAGTGGGTT TACTGAAGAA TTTGAGACAC TGAAAGAGTT TTACCAGGAA 2760

GTGCAGAGCT GTACTGTTGA CTTAGGTATT ACAGCAGACA GCTCCAACCA CCCAGACAAC 2820

AAGCACAAGA ATCGATACAT AAATATCGTT GCCTATGATC ATAGCAGGGT TAAGCTAGCA 2880

CAGCTTGCTG AAAAGGATGG CAAACTGACT GATTATATCA ATGCCAATTA TGTTGATGGC 2940

TACAACAGAC CAAAAGCTTA TATTGCTGCC CAAGGCCCAC TGAAATCCAC AGCTGAAGAT 3000

TTCTGGAGAA TGATATGGGA ACATAATGTG GAAGTTATTG TCATGATAAC AAACCTCGTG 3060

GAGAAAGGAA GGAGAAAATG TGATCAGTAC TGGCCTGCCG ATGGGAGTGA GGAGTACGGG 3120

AACTTTCTGG TCACTCAGAA GAGTGTGCAA GTGCTTGCCT ATTATACTGT GAGGAATTTT 3180

ACTCTAAGAA ACACAAAAAT AAAAAAGGGC TCCCAGAAAG GAAGACCCAG TGGACGTGTG 3240

GTCACACAGT ATCACTACAC GCAGTGGCCT GACATGGGAG TACCAGAGTA CTCCCTGCCA 3300

GTGCTGACCT TTGTGAGAAA GGCAGCCTAT GCCAAGCGCC ATGCAGTGGG GCCTGTTGTC 3360

GTCCACTGCA GTGCTGGAGT TGGAAGAACA GGCACATATA TTGTGCTAGA CAGTATGTTG 3420

CAGCAGATTC AACACGAAGG AACTGTCAAC ATATTTGGCT TCTTAAAACA CATCCGTTCA 3480

CAAAGAAATT ATTTGGTACA AACTGAGGAG CAATATGTCT TCATTCATGA TACACTGGTT 3540

GAGGCCATAC TTAGTAAAGA AACTGAGGTG CTGGACAGTC ATATTCATGC CTATGTTAAT 3600

GCACTCCTCA TTCCTGGACC AGCAGGCAAA ACAAAGCTAG AGAAACAATT CCAGCTCCTG 3660

AGCCAGTCAA ATATACAGCA GAGTGACTAT TCTGCAGCCC TAAAGCAATG CAACAGGGAA 3720

AAGAATCGAA CTTCTTCTAT CATCCCTGTG GAAAGATCAA GGGTTGGCAT TTCATCCCTG 3780

AGTGGAGAAG GCACAGACTA CATCAATGCC TCCTATATCA TGGGCTATTA CCAGAGCAAT 3840

GAATTCATCA TTACCCAGCA CCCTCTCCTT CATACCATCA AGGATTTCTG GAGGATGATA 3900

TGGGACCATA ATGCCCAACT GGTGGTTATG ATTCCTGATG GCCAAAACAT GGCAGAAGAT 3960

GAATTTGTTT ACTGGCCAAA TAAAGATGAG CCTATAAATT GTGAGAGCTT TAAGGTCACT 4020

CTTATGGCTG AAGAACACAA ATGTCTATCT AATGAGGAAA AACTTATAAT TCAGGACTTT 4080

ATCTTAGAAG CTACACAGGA TGATTATGTA CTTGAAGTGA GGCACTTTCA GTGTCCTAAA 4140

TGGCCAAATC CAGATAGCCC CATTAGTAAA ACTTTTGAAC TTATAAGTGT TATAAAAGAA 4200

GAAGCTGCCA ATAGGGATGG GCCTATGATT GTTCATGATG AGCATGGAGG AGTGACGGCA 4260

GGAACTTTCT GTGCTCTGAC AACCCTTATG CACCAACTAG AAAAAGAAAA TTCCGTGGAT 4320

GTTTACCAGG TAGCCAAGAT GATCAATCTG ATGAGGCCAG GAGTCTTTGC TGACATTGAG 4380

CAGTATCAGT TTCTCTACAA AGTGATCCTC AGCCTTGTGA GCACAAGGCA GGAAGAGAAT 4440

CCATCCACCT CTCTGGACAG TAATGGTGCA GCATTGCCTG ATGGAAATAT AGCTGAGAGC 4500

TTAGAGTCTT TAGTTTAACA CAGAAAGGGG TGGGGGGACT CACATCTGAG CATTGTTTTC 4560

CTCTTCCTAA AATTAGGCAG GAAAATCAGT CTAGTTCTGT TATCTGTTGA TTTCCCATCA 4620

CCTGACAGTA ACTTTCATGA CATAGGATTC TGCCGCCAAA TTTATATCAT TAACAATGTG 4680

TGCCTTTTTG CAAGACTTGT AATTTACTTA TTATGTTTGA ACTAAAATGA TTGAATTTTA 4740

CAGTATTTCT AAGAATGGAA TTGTGGTATT TTTTTCTGTA TTGATTTTAA CAGAAAATTT 4800

CAATTTATAG AGGTTAGGAA TTCCAAACTA CAGAAAATGT TTGTTTTTAG TGTCAAATTT 4860

TTAGCTGTAT TTGTAGCAAT TATCAGGTTT GCTAGAAATA TAACTTTTAA TACAGTAGCC 4920

TGTAAATAAA ACACTCTTCC ATATGATATT CAACATTTTA CAACTGCAGT ATTCACCTAA 4g80

AGTAGAAATA ATCTGTTACT TATTGTAAAT ACTGCCCTAG TGTCTCCATG GACCAAATTT 5040

ATATTTATAA TTGTAGATTT TTATATTTTA CTACTGAGTC AAGTTTTCTA GTTCTGTGTA 5100

ATTGTTTAGT TTAATGACGT AGTTCATTAG CTGGTCTTAC TCTACCAGTT TTCTGACATT 5160

GTATTGTGTT ACCTAAGTCA TTAACTTTGT TTCAGCATGT AATTTTAACT TTTGTGGAAA 5220

ATAGAAATAC CTTCATTTTG AAAGAAGTTT TTATGAGAAT AACACCTTAC CAAACATTGT 5280

TCAAATGGTT TTTATCCAAG GAATTGCAAA AATAAATATA AATATTGCCA TTAAAAAAAA 5340 AAAAAAAAAA AAAAAAAAAA AAAAAAA

Seq ID NO: 575 Protein sequence: Protein Accession ft: Eos sequence

1 11 21 31 41 51

I I I 1 I 1

MRILKRFLAC IQLLCVCRLD WANGYYRQQR KLVEEIGWSY TGALNQKNWG KKYPTCNSPK 60

QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 120

FKASKITFHW GKCNMSSDGS EHSLEGQKFP LEMQIYCFDA DRFSSFEEAV KGKGKLRALS 180

ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 240

TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 300

TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPRWYD TMIEKFAVLY QQLDGEDQTK 360

HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY SDQLIVDMPT DNPELDLFPE 420

LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 480

RSPTRGSEFS GKGDVPNTSL NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND 540

GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS 600

ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG NVWFPSSTDI 660

TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 720

TEVTPHAFTP SSRQQDLVST VNWYSQTTQ PVYNAEASNS SHESRIGLAE GLESEKKAVI 780

PLVIVSALTF ICLWLVGIL IYWRKCFQTA HFYLEDSTSP RVISTPPTPI FPISDDVGAI 840

PIKHFPKHVA DLHASSGFTE EFETLKEFYQ EVQSCTVDLG ITADSSNHPD NKHKNRYINI 900

VAYDHSRVKL AQLAEKDGKL TDYINANYVD GYNRPKAYIA AQGPLKSTAE DFWRMIWEHN 960

VEVIVMITNL VEKGRRKCDQ YWPADGSEEY GNFLVTQKSV QVLAYYTVRN FTLRNTKIKK 1020

GSQKGRPSGR WTQYHYTQW PDMGVPEYSL PVLTFVRKAA YAKRHAVGPV HCSAGVGR 1080

TGTYIVLDSM LQQIQHEGTV NIFGFLKHIR SQRNYLVQTE EQYVFIHDTL VEAILSKETE 1140

VLDSHIHAYV NALLIPGPAG KTKLEKQFQL LSQSNIQQSD YSAALKQCNR EKNRTSSIIP 1200

VERSRVGISS LSGEGTDYIN ASYIMGYYQS NEFIITQHPL LHTIKDFWRM IWDHNAQLW 1260

MIPDGQNMAE DEFVYWPNKD EPINCESFKV TLMAEEHKCL SNEEKLIIQD FILEATQDDY 1320

VLEVRHFQCP KWPNPDSPIS KTFELISVIK EEAANRDGPM IVHDEHGGVT AGTFCALTTL 1380

MHQLEKENSV DVYQVAKMIN LMRPGVFADI EQYQFLYKVI LSLVSTRQEE NPSTSLDSNG 1440 AALPDGNIAE SLESLV Seq ID NO: 576 DNA sequence

Nucleic Acid Accession ft: EOS sequence

Coding sequence: 148-4494

1 11 21 31 41 51

C IACACATACG CIACGCACGAT CITCACTTCGA TICTATACACT GIGAGGATTAA AIACAAACAAA 60

CAAAAAAAAC ATTTCCTTCG CTCCCCCTCC CTCTCCACTC TGAGAAGCAG AGGAGCCGCA 120

CGGCGAGGGG CCGCAGACCG TCTGGAAATG CGAATCCTAA AGCGTTTCCT CGCTTGCATT 180

CAGCTCCTCT GTGTTTGCCG CCTGGATTGG GCTAATGGAT ACTACAGACA ACAGAGAAAA 240

CTTGTTGAAG AGATTGGCTG GTCCTATACA GGAGCACTGA ATCAAAAAAA TTGGGGAAAG 300

AAATATCCAA CATGTAATAG CCCAAAACAA TCTCCTATCA ATATTGATGA AGATCTTACA 360

CAAGTAAATG TGAATCTTAA GAAACTTAAA TTTCAGGGTT GGGATAAAAC ATCATTGGAA 420

AACACATTCA TTCATAACAC TGGGAAAACA GTGGAAATTA ATCTCACTAA TGACTACCGT 480

GTCAGCGGAG GAGTTTCAGA AATGGTGTTT AAAGCAAGCA AGATAACTTT TCACTGGGGA 540

AAATGCAATA TGTCATCTGA TGGATCAGAG CATAGTTTAG AAGGACAAAA ATTTCCACTT 600

GAGATGCAAA TCTACTGCTT TGATGCAGAC CGATTTTCAA GTTTTGAGGA AGCAGTCAAA 660

GGAAAAGGGA AGTTAAGAGC TTTATCCATT TTGTTTGAGG TTGGGACAGA AGAAAATTTG 720

GATTTCAAAG CGATTATTGA TGGAGTCGAA AGTGTTAGTC GTTTTGGGAA GCAGGCTGCT 780

TTAGATCCAT TCATACTGTT GAACCTTCTG CCAAACTCAA CTGACAAGTA TTACATTTAC 840

AATGGCTCAT TGACATCTCC TCCCTGCACA GACACAGTTG ACTGGATTGT TTTTAAAGAT 900

ACAGTTAGCA TCTCTGAAAG CCAGTTGGCT GTTTTTTGTG AAGTTCTTAC AATGCAACAA 960

TCTGGTTATG TCATGCTGAT GGACTACTTA CAAAACAATT TTCGAGAGCA ACAGTACAAG 1020

TTCTCTAGAC AGGTGTTTTC CTCATACACT GGAAAGGAAG AGATTGATGA AGCAGTTTGT 1080

AGTTCAGAAC CAGAAAATGT TCAGGCTGAC CCAGAGAATT ATACCAGCCT TCTTGTTACA 1140

TGGGAAAGAC CTCGAGTCGT TTATGATACC ATGATTGAGA AGTTTGCAGT TTTGTACCAG 1200

CAGTTGGATG GAGAGGACCA AACCAAGCAT GAATTTTTGA CAGATGGCTA TCAAGACTTG 1260

GGTGCTATTC TCAATAATTT GCTACCCAAT ATGAGTTATG TTCTTCAGAT AGTAGCCATA 1320

TGCACTAATG GCTTATATGG AAAATACAGC GACCAACTGA TTGTCGACAT GCCTACTGAT 1380

AATCCTGAAC TTGATCTTTT CCCTGAATTA ATTGGAACTG AAGAAATAAT CAAGGAGGAG 1440

GAAGAGGGAA AAGACATTGA AGAAGGCGCT ATTGTGAATC CTGGTAGAGA CAGTGCTACA 1500

AACCAAATCA GGAAAAAGGA ACCCCAGATT TCTACCACAA CACACTACAA TCGCATAGGG 1560

ACGAAATACA ATGAAGCCAA GACTAACCGA TCCCCAACAA GAGGAAGTGA ATTCTCTGGA 1620

AAGGGTGATG TTCCCAATAC ATCTTTAAAT TCCACTTCCC AACCAGTCAC TAAATTAGCC 1680

ACAGAAAAAG ATATTTCCTT GACTTCTCAG ACTGTGACTG AACTGCCACC TCACACTGTG 1740

GAAGGTACTT CAGCCTCTTT AAATGATGGC TCTAAAACTG TTCTTAGATC TCCACATATG 1800

AACTTGTCGG GGACTGCAGA ATCCTTAAAT ACAGTTTCTA TAACAGAATA TGAGGAGGAG 1860

AGTTTATTGA CCAGTTTCAA GCTTGATACT GGAGCTGAAG ATTCTTCAGG CTCCAGTCCC 1920

GCAACTTCTG CTATCCCATT CATCTCTGAG AACATATCCC AAGGGTATAT ATTTTCCTCC 1980

GAAAACCCAG AGACAATAAC ATATGATGTC CTTATACCAG AATCTGCTAG AAATGCTTCC 2040

GAAGATTCAA CTTCATCAGG TTCAGAAGAA TCACTAAAGG ATCCTTCTAT GGAGGGAAAT 2100

GTGTGGTTTC CTAGCTCTAC AGACATAACA GCACAGGCCG ATGTTGGATC AGGCAGAGAG 2160

AGCTTTCTCC AGACTAATTA CACTGAGATA CGTGTTGATG AATCTGAGAA GACAACCAAG 2220

TCCTTTTCTG CAGGCCCAGT GATGTCACAG GGTCCCTCAG TTACAGATCT GGAAATGCCA 2280

CATTATTCTA CCTTTGCCTA CTTCCCAACT GAGGTAACAC CTCATGCTTT TACCCCATCC 2340

TCCAGACAAC AGGATTTGGT CTCCACGGTC AACGTGGTAT ACTCGCAGAC AACCCAACCG 2400

GTATACAATG AGGCCAGTAA TAGTAGCCAT GAGTCTCGTA TTGGTCTAGC TGAGGGGTTG 2460

GAATCCGAGA AGAAGGCAGT TATACCCCTT GTGATCGTGT CAGCCCTGAC TTTTATCTGT 2520

CTAGTGGTTC TTGTGGGTAT TCTCATCTAC TGGAGGAAAT GCTTCCAGAC TGCACACTTT 2580

TACTTAGAGG ACAGTACATC CCCTAGAGTT ATATCCACAC CTCCAACACC TATCTTTCCA 2640

ATTTCAGATG ATGTCGGAGC AATTCCAATA AAGCACTTTC CAAAGCATGT TGCAGATTTA 2700

CATGCAAGTA GTGGGTTTAC TGAAGAATTT GAGGAAGTGC AGAGCTGTAC TGTTGACTTA 2760

GGTATTACAG CAGACAGCTC CAACCACCCA GACAACAAGC ACAAGAATCG ATACATAAAT 2820

ATCGTTGCCT ATGATCATAG CAGGGTTAAG CTAGCACAGC TTGCTGAAAA GGATGGCAAA 2880

CTGACTGATT ATATCAATGC CAATTATGTT GATGGCTACA ACAGACCAAA AGCTTATATT 2940

GCTGCCCAAG GCCCACTGAA ATCCACAGCT GAAGATTTCT GGAGAATGAT ATGGGAACAT 3000

AATGTGGAAG TTATTGTCAT GATAACAAAC CTCGTGGAGA AAGGAAGGAG AAAATGTGAT 3060

CAGTACTGGC CTGCCGATGG GAGTGAGGAG TACGGGAACT TTCTGGTCAC TCAGAAGAGT 3120

GTGCAAGTGC TTGCCTATTA TACTGTGAGG AATTTTACTC TAAGAAACAC AAAAATAAAA 3180

AAGGGCTCCC AGAAAGGAAG ACCCAGTGGA CGTGTGGTCA CACAGTATCA CTACACGCAG 3240

TGGCCTGACA TGGGAGTACC AGAGTACTCC CTGCCAGTGC TGACCTTTGT GAGAAAGGCA 3300

GCCTATGCCA AGCGCCATGC AGTGGGGCCT GTTGTCGTCC ACTGCAGTGC TGGAGTTGGA 3360

AGAACAGGCA CATATATTGT GCTAGACAGT ATGTTGCAGC AGATTCAACA CGAAGGAACT 3420

GTCAACATAT TTGGCTTCTT AAAACACATC CGTTCACAAA GAAATTATTT GGTACAAACT 3480

GAGGAGCAAT ATGTCTTCAT TCATGATACA CTGGTTGAGG CCATACTTAG TAAAGAAACT 3540

GAGGTGCTGG ACAGTCATAT TCATGCCTAT GTTAATGCAC TCCTCATTCC TGGACCAGCA 3600

GGCAAAACAA AGCTAGAGAA ACAATTCCAG CTCCTGAGCC AGTCAAATAT ACAGCAGAGT 3660

GACTATTCTG CAGCCCTAAA GCAATGCAAC AGGGAAAAGA ATCGAACTTC TTCTATCATC 3720

CCTGTGGAAA GATCAAGGGT TGGCATTTCA TCCCTGAGTG GAGAAGGCAC AGACTACATC 3780

AATGCCTCCT ATATCATGGG CTATTACCAG AGCAATGAAT TCATCATTAC CCAGCACCCT 3840

CTCCTTGATA CCATCAAGGA TTTCTGGAGG ATGATATGGG ACCATAATGC CCAACTGGTG 3900

GTTATGATTC CTGATGGCCA AAACATGGCA GAAGATGAAT TTGTTTACTG GCCAAATAAA 3960

GATGAGCCTA TAAATTGTGA GAGCTTTAAG^" GTCACTCTTA TGGCTGAAGA ACACAAATGT 4020

CTATCTAATG AGGAAAAACT TATAATTCAG GACTTTATCT TAGAAGCTAC ACAGGATGAT 4080

TATGTACTTG AAGTGAGGCA CTTTCAGTGT CCTAAATGGC CAAATCCAGA TAGCCCCATT 4140

AGTAAAACTT TTGAACTTAT AAGTGTTATA AAAGAAGAAG CTGCCAATAG GGATGGGCCT 4200

ATGATTGTTC ATGATGAGCA TGGAGGAGTG ACGGCAGGAA CTTTCTGTGC TCTGACAACC 4260

CTTATGCACC AACTAGAAAA AGAAAATTCC GTGGATGTTT ACCAGGTAGC CAAGATGATC 4320

AATCTGATGA GGCCAGGAGT CTTTGCTGAC ATTGAGCAGT ATCAGTTTCT CTACAAAGTG 4380

ATCCTCAGCC TTGTGAGCAC AAGGCAGGAA GAGAATCCAT CCACCTCTCT GGACAGTAAT 4440

GGTGCAGCAT TGCCTGATGG AAATATAGCT GAGAGCTTAG AGTCTTTAGT TTAACACAGA 4500

AAGGGGTGGG GGGACTCACA TCTGAGCATT GTTTTCCTCT TCCTAAAATT AGGCAGGAAA 4560

ATCAGTCTAG TTCTGTTATC TGTTGATTTC CCATCACCTG ACAGTAACTT TCATGACATA 4620

GGATTCTGCC GCCAAATTTA TATCATTAAC AATGTGTGCC TTTTTGCAAG ACTTGTAATT 4680

TACTTATTAT GTTTGAACTA AAATGATTGA ATTTTACAGT ATTTCTAAGA ATGGAATTGT 4740

GGTATTTTTT TCTGTATTGA TTTTAACAGA AAATTTCAAT TTATAGAGGT TAGGAATTCC 4800 AAACTACAGA AAATGTTTGT TTTTAGTGTC AAATTTTTAG CTGTATTTGT AGCAATTATC 4860

AGGTTTGCTA GAAATATAAC TTTTAATACA GTAGCCTGTA AATAAAACAC TCTTCCATAT 4g20

GATATTCAAC ATTTTACAAC TGCAGTATTC ACCTAAAGTA GAAATAATCT GTTACTTATT 4980

GTAAATACTG CCCTAGTGTC TCCATGGACC AAATTTATAT TTATAATTGT AGATTTTTAT 5040

ATTTTACTAC TGAGTCAAGT TTTCTAGTTC TGTGTAATTG TTTAGTTTAA TGACGTAGTT 5100

CATTAGCTGG TCTTACTCTA CCAGTTTTCT GACATTGTAT TGTGTTACCT AAGTCATTAA 5160

CTTTGTTTCA GCATGTAATT TTAACTTTTG TGGAAAATAG AAATACCTTC ATTTTGAAAG 5220

AAGTTTTTAT GAGAATAACA CCTTACCAAA CATTGTTCAA ATGGTTTTTA TCCAAGGAAT 5280

TGCAAAAATA AATATAAATA TTGCCATTAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 5340 AAA

Seq ID NO: 577 Protein sequence: Protein Accession ft: EOS sequence

1 11 21 31 41 51

I I I I I I

MRILKRFLAC IQLLCVCRLD WANGYYRQQR KLVEEIGWSY TGALNQKNWG KKYPTCNSPK 60

QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 120

FKASKITFHW GKCNMSSDGS EHSLEGQKFP LEMQIYCFDA DRFSSFEEAV KGKGKLRALS 180

ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 240

TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 300

TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPRWYD TMIEKFAVLY QQLDGEDQTK 360

HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY SDQLIVDMPT DNPELDLFPE 420

LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 480

RSPTRGSEFS GKGDVPNTSL NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND 540

GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS 600

ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG NVWFPSSTDI 660

TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 720

TEVTPHAFTP SSRQQDLVST VNWYSQTTQ PVYNEASNSS HESRIGLAEG LESEKKAVIP 780

LVIVSALTFI CLWLVGILI YWRKCFQTAH FYLEDSTSPR VISTPPTPIF PISDDVGAIP 840

IKHFPKHVAD LHASSGFTEE FEEVQSCTVD LGITADSSNH PDNKHKNRYI NIVAYDHSRV 900

KLAQLAEKDG KLTDYINANY VDGYNRPKAY IAAQGPLKST AEDFWRMIWE HNVEVIVMIT 960

NLVEKGRRKC DQYWPADGSE EYGNFLVTQK SVQVLAYYTV RNFTLRNTKI KKGSQKGRPS 1020

GRWTQYHYT QWPDMGVPEY SLPVLTFVRK AAYAKRHAVG PVWHCSAGV GRTGTYIVLD 1080

SMLQQIQHEG TVNIFGFLKH IRSQRNYLVQ TEEQYVFIHD TLVEAILSKE TEVLDSHIHA 1140

YVNALLIPGP AGKTKLEKQF QLLSQSNIQQ SDYSAALKQC NREKNRTSSI IPVERSRVGI 1200

SSLSGEGTDY INASYIMGYY QSNEFIITQH PLLHTIKDFW RMIWDHNAQL MIPDGQNM 1260

AEDEFVYWPN KDEPINCESF KVTLMAEEHK CLSNEEKLII QDFILEATQD DYVLEVRHFQ 1320

CPKWPNPDSP ISKTFELISV IKEEAANRDG PMIVHDEHGG VTAGTFCALT TLMHQLEKEN 1380

SVDVYQVAKM INLMRPGVFA DIEQYQFLYK VILSLVSTRQ EENPSTSLDS NGAALPDGNI 1440 AESLESLV

Seq ID NO: 578 DNA sequence

Nucleic Acid Accession ft: EOS sequence

Coding sequence: 501-4514

1 11 21 31 41 51

CACACATACG CACGCACGAT CTCACTTCGA TCTATACACT GGAGGATTAA AACAAACAAA 60

CAAAAAAAAC ATTTCCTTCG CTCCCCCTCC CTCTCCACTC TGAGAAGCAβ AGGAGCCGCA 120

CGGCGAGGGG CCGCAGACCG TCTGGAAATG CGAATCCTAA AGCGTTTCCT CGCTTGCATT 180

CAGCTCCTCT GTGTTTGCCG CCTGGATTGG GCTAATGGAT ACTACAGACA ACAGAGAAAA 240

CTTGTTGAAG AGATTGGCTG GTCCTATACA GGAGCACTGA ATCAAAAAAT TGGGGAAAGA 300

AATATCCAAC ATGTAATAGC CCAAAACAAT CTCCTATCAA TATTGATGAA GATCTTACAC 360

AAGTAAATGT GAATCTTAAG AAACTTAAAT TTCAGGGTTG GGATAAAACA TCATTGGAAA 420

ACACATTCAT TCATAACACT GGGAAAACAG TGGAAATTAA TCTCACTAAT GACTACCGTG 480

TCAGCGGAGG AGTTTCAGAA ATGGTGTTTA AAGCAAGCAA GATAACTTTT CACTGGGGAA 540

AATGCAATAT GTCATCTGAT GGATCAGAGC ATAGTTTAGA AGGACAAAAA TTTCCACTTG 600

AGATGCAAAT CTACTGCTTT GATGCGGACC GATTTTCAAG TTTTGAGGAA GCAGTCAAAG 660

GAAAAGGGAA GTTAAGAGCT TTATCCATTT TGTTTGAGGT TGGGACAGAA GAAAATTTGG 720

ATTTCAAAGC GATTATTGAT GGAGTCGAAA GTGTTAGTCG TTTTGGGAAβ CAGGCTGCTT 780

TAGATCCATT CATACTGTTG AACCTTCTGC CAAACTCAAC TGACAAGTAT TACATTTACA 840

ATGGCTCATT GACATCTCCT CCCTGCACAG ACACAGTTGA CTGGATTGTT TTTAAAGATA 900

CAGTTAGCAT CTCTGAAAGC CAGTTGGCTG TTTTTTGTGA AGTTCTTACA ATGCAACAAT 960

CTGGTTATGT CATGCTGATG GACTACTTAC AAAACAATTT TCGAGAGCAA CAGTACAAGT 1020

TCTCTAGACA GGTGTTTTCC TCATACACTG GAAAGGAAGA GATTCATGAA GCAGTTTGTA 1080

GTTCAGAACC AGAAAATGTT CAGGCTGACC CAGAGAATTA TACCAGCCTT CTTGTTACAT 1140

GGGAAAGACC TCGAGTCGTT TATGATACCA TGATTGAGAA GTTTGCAGTT TTGTACCAGC 1200

AGTTGGATGG AGAGGACCAA ACCAAGCATG AATTTTTGAC AGATGGCTAT CAAGACTTGG 1260

GTGCTATTCT CAATAATTTG CTACCCAATA TGAGTTATGT TCTTCAGATA GTAGCCATAT 1320

GCACTAATGG CTTATATGGA AAATACAGCG ACCAACTGAT TGTCGACATG CCTACTGATA 1380

ATCCTGAACT TGATCTTTTC CCTGAATTAA TTGGAACTGA AGAAATAATC AAGGAGGAGG 1440

AAGAGGGAAA AGACATTGAA GAAGGCGCTA TTGTGAATCC TGGTAGAGAC AGTGCTACAA 1500

ACCAAATCAG GAAAAAGGAA CCCCAGATTT CTACCACAAC ACACTACAAT CGCATAGGGA 1560

CGAAATACAA TGAAGCCAAG ACTAACCGAT CCCCAACAAG AGGAAGTGAA TTCTCTGGAA 1620

AGGGTGATGT TCCCAATACA TCTTTAAATT CCACTTCCCA ACCAGTCACT AAATTAGCCA 1680

CAGAAAAAGA TATTTCCTTG ACTTCTCAGA CTGTGACTGA ACTGCCACCT CACACTGTGG 1740

AAGGTACTTC AGCCTCTTTA AATGATGGCT CTAAAACTGT TCTTAGATCT CCACATATGA 1800 ACTTGTCGGG GACTGCAGAA TCCTTAAATA CAGTTTCTAT AACAGAATAT GAGGAGGAGA 1860

GTTTATTGAC CAGTTTCAAG CTTGATACTG GAGCTGAAGA TTCTTCAGGC TCCAGTCCCG 1920

CAACTTCTGC TATCCCATTC ATCTCTGAGA ACATATCCCA AGGGTATATA TTTTCCTCCG 1980

AAAACCCAGA GACAATAACA TATGATGTCC TTATACCAGA ATCTGCTAGA AATGCTTCCG 2040

AAGATTCAAC TTCATCAGGT TCAGAAGAAT CACTAAAGGA TCCTTCTATG GAGGGAAATG 2100

TGTGGTTTCC TAGCTCTACA GACATAACAG CACAGCCCGA TGTTGGATCA GGCAGAGAGA 2160

GCTTTCTCCA GACTAATTAC ACTGAGATAC GTGTTGATGA ATCTGAGAAG ACAACCAAGT 2220

CCTTTTCTGC AGGCCCAGTG ATGTCACAGG GTCCCTCAGT TACAGATCTG GAAATGCCAC 2280 ATTATTCTAC CTTTGCCTAC TTCCCAACTG AGGTAACACC TCATGCTTTT AGCCCATCCT 2340

CCAGACAACA GGATTTGGTC TCCACGGTCA ACGTGGTATA CTCGCAGACA ACCCAACCGG 2400

TATACAATGA GGCCAGTAAT AGTAGCCATG AGTCTCGTAT TGGTCTAGCT GAGGGGTTGG 2460

AATCCGAGAA GAAGGCAGTT ATACCCCTTG TGATCGTGTC AGCCCTGACT TTTATCTGTC 2520

TAGTGGTTCT TGTGGGTATT CTCATCTACT GGAGGAAATG CTTCCAGACT GCACACTTTT 2580

ACTTAGAGGA CAGTACATCC CCTAGAGTTA TATCCACACC TCCAACACCT ATCTTTCCAA 2640

TTTCAGATGA TGTCGGAGCA ATTCCAATAA AGCACTTTCC AAAGCATGTT GCAGATTTAC 2700

ATGCAAGTAG TGGGTTTACT GAAGAATTTG AGACACTGAA AGAGTTTTAC CAGGAAGTGC 2760

AGAGCTGTAC TGTTGACTTA GGTATTACAG CAGACAGCTC CAACCACCCA GACAACAAGC 2820

ACAAGAATCG ATACATAAAT ATCGTTGCCT ATGATCATAG CAGGGTTAAG CTAGCACAGC 2880

TTGCTGAAAA GGATGGCAAA CTGACTGATT ATATCAATGC CAATTATGTT GATGGCTACA 2 40

ACAGACCAAA AGCTTATATT GCTGCCCAAG GCCCACTGAA ATCCACAGCT GAAGATTTCT 3000

GGAGAATGAT ATGGGAACAT AATGTGGAAG TTATTGTCAT GATAACAAAC CTCGTGGAGA 3060

AAGGAAGGAG AAAATGTGAT CAGTACTGGC CTGCCGATGG GAGTGAGGAG TACGGGAACT 3120

TTCTGGTCAC TCAGAAGAGT GTGCAAGTGC TTGCCTATTA TACTGTGAGG AATTTTACTC 3180

TAAGAAACAC AAAAATAAAA AAGGGCTCCC AGAAAGGAAG ACCCAGTGGA CGTGTGGTCA 3240

CACAGTATCA CTACACGCAG TGGCCTGACA TGGGAGTACC AGAGTACTCC CTGCCAGTGC 3300

TGACCTTTGT GAGAAAGGCA GCCTATGCCA AGCGCCATGC AGTGGGGCCT GTTGTCGTCC 3360

ACTGCAGTGC TGGAGTTGGA AGAACAGGCA CATATATTGT GCTAGACAGT ATGTTGCAGC 3420

AGATTCAACA CGAAGGAACT GTCAACATAT TTGGCTTCTT AAAACACATC CGTTCACAAA 3480

GAAATTATTT GGTACAAACT GAGGAGCAAT ATGTCTTCAT TCATGATACA CTGGTTGAGG 3540

CCATACTTAG TAAAGAAACT GAGGTGCTGG ACAGTCATAT TCATGCCTAT GTTAATGCAC 3600

TCCTCATTCC TGGACCAGCA GGCAAAACAA AGCTAGAGAA ACAATTCCAG CTCCTGAGCC 3660

AGTCAAATAT ACAGCAGAGT GACTATTCTG CAGCCCTAAA GCAATGCAAC AGGGAAAAGA 3720

ATCGAACTTC TTCTATCATC CCTGTGGAAA GATCAAGGGT TGGCATTTCA TCCCTGAGTG 3780

GAGAAGGCAC AGACTACATC AATGCCTCCT ATATCATGGG CTATTACCAG AGCAATGAAT 3840

TCATCATTAC CCAGCACCCT CTCCTTCATA CCATCAAGGA TTTCTGGAGG ATGATATGGG 3900

ACCATAATGC CCAACTGGTG GTTATGATTC CTGATGGCCA AAACATGGCA GAAGATGAAT 3960

TTGTTTACTG GCCAAATAAA GATGAGCCTA TAAATTGTGA GAGCTTTAAG GTCACTCTTA 4020

TGGCTGAAGA ACACAAATGT CTATCTAATG AGGAAAAACT TATAATTCAG GACTTTATCT 4080

TAGAAGCTAC ACAGGATGAT TATGTACTTG AAGTGAGGCA CTTTCAGTGT CCTAAATGGC 4140

CAAATCCAGA TAGCCCCATT AGTAAAACTT TTGAACTTAT AAGTGTTATA AAAGAAGAAG 4200

CTGCCAATAG GGATGGGCCT ATGATTGTTC ATGATGAGCA TGGAGGAGTG ACGGCAGGAA 4260

CTTTCTGTGC TCTGACAACC CTTATGCACC AACTAGAAAA AGAAAATTCC GTGGATGTTT 4320

ACCAGGTAGC CAAGATGATC AATCTGATGA GGCCAGGAGT CTTTGCTGAC ATTGAGCAGT 4380

ATCAGTTTCT CTACAAAGTG ATCCTCAGCC TTGTGAGCAC AAGGCAGGAA GAGAATCCAT 4440

CCACCTCTCT GGACAGTAAT GGTGCAGCAT TGCCTGATGG AAATATAGCT GAGAGCTTAG 4500

AGTCTTTAGT TTAACACAGA AAGGGGTGGG GGGACTCACA TCTGAGCATT GTTTTCCTCT 4560

TCCTAAAATT AGGCAGGAAA ATCAGTCTAG TTCTGTTATC TGTTGATTTC CCATCACCTG 4620

ACAGTAACTT TCATGACATA GGATTCTGCC GCCAAATTTA TATCATTAAC AATGTGTGCC 4680

TTTTTGCAAG ACTTGTAATT TACTTATTAT GTTTGAACTA AAATGATTGA ATTTTACAGT 4740

ATTTCTAAGA ATGGAATTGT GGTATTTTTT TCTGTATTGA TTTTAACAGA AAATTTCAAT 4800

TTATAGAGGT TAGGAATTCC AAACTACAGA AAATGTTTGT TTTTAGTGTC AAATTTTTAG 4860

CTGTATTTGT AGCAATTATC AGGTTTGCTA GAAATATAAC TTTTAATACA GTAGCCTGTA 4920

AATAAAACAC TCTTCCATAT GATATTCAAC ATTTTACAAC TGCAGTATTC ACCTAAAGTA 4980

GAAATAATCT GTTACTTATT GTAAATACTG CCCTAGTGTC TCCATGGACC AAATTTATAT 5040

TTATAATTGT AGATTTTTAT ATTTTACTAC TGAGTCAAGT TTTCTAGTTC TGTGTAATTG 5100

TTTAGTTTAA TGACGTAGTT CATTAGCTGG TCTTACTCTA CCAGTTTTCT GACATTGTAT 5160

TGTGTTACCT AAGTCATTAA CTTTGTTTCA GCATGTAATT TTAACTTTTG TGGAAAATAG 5220

AAATACCTTC ATTTTGAAAG AAGTTTTTAT GAGAATAACA CCTTACCAAA CATTGTTCAA 5280

ATGGTTTTTA TCCAAGGAAT TGCAAAAATA AATATAAATA TTGCCATTAA AAAAAAAAAA 5340 AAAAAAAAAA AAAAAAAAAA AAA

Seq ID NO: 579 Protein sequence: Protein Accession ft : EOS sequence

1 11 21 31 41 51

M IVFKASKITF HIWGKCNMSSD GISEHSLEGQK FIPLEMQIYCF DIADRFSSFEE AIVKGKGKLRA 60

LSILFEVGTE ENLDFKAIID GVESVSRFGK QAALDPFILL NLLPNSTDKY YIYNGSLTSP 120

PCTDTVDWIV FKDTVSISES QLAVFCEVLT MQQSGYVMLM DYLQNNFREQ QYKFSRQVFS 180

SYTGKEEIHE AVCSSEPENV QADPENYTSL LVTWERPRW YDTMIEKFAV LYQQLDGEDQ 240

TKHEFLTDGY QDLGAILNNL LPNMSYVLQI VAICTNGLYG KYSDQLIVDM PTDNPELDLF 300

PELIGTEEII KEEEEGKDIE EGAIVNPGRD SATNQIRKKE PQISTTTHYN RIGTKYNEAK 360

TNRSPTRGSE FSGKGDVPNT SLNSTSQPVT KLATEKDISL TSQTVTELPP HTVEGTSASL 420

NDGSKTVLRS PHMNLSGTAE SLNTVSITEY EEESLLTSFK LDTGAEDSSG SSPATSAIPF 480

ISENISQGYI FSSENPETIT YDVLIPESAR NASEDSTSSG SEESLKDPSM EGNVWFPSST 540

DITAQPDVGS GRESFLQTNY TEIRVDESEK TTKSFSAGPV MSQGPSVTDL EMPHYSTFAY 600

FPTEVTPHAF TPSSRQQDLV STVNWYSQT TQPVYNEASN SSHESRIGLA EGLESEKKAV 660

IPLVIVSALT FICLWLVGI LIYWRKCFQT AHFYLEDSTS PRVISTPPTP IFPISDDVGA 720

IPIKHFPKHV ADLHASSGFT EEFETLKEFY QEVQSCTVDL GITADSSNHP DNKHKNRYIN 780

IVAYDHSRVK LAQLAEKDGK LTDYINANYV DGYNRPKAYI AAQGPLKSTA EDFWRMIWEH 840

NVEVIVMITN LVEKGRRKCD QYWPADGSEE YGNFLVTQKS VQVLAYYTVR NFTLRNTKIK 900

KGSQKGRPSG RWTQYHYTQ WPDMGVPEYS LPVLTFVRKA AYAKRHAVGP VWHCSAGVG 960

RTGTYIVLDS MLQQIQHEGT VNIFGFLKHI RSQRNYLVQT .EEQYVFIHDT LVEAILSKET 1020

EVLDSHIHAY VNALLIPGPA GKTKLEKQFQ LLSQSNIQQS DYSAALKQCN REKNRTSSII 1080

PVERSRVGIS SLSGEGTDYI NASYIMGYYQ SNEFIITQHP LLHTIKDFWR MIWDHNAQLV 1140

VMIPDGQNMA EDEFVYWPNK^' DEPINCESFK VTLMAEEHKC LSNEEKLIIQ DFILEATQDD 1200

YVLEVRHFQC PKWPNPDSPI SKTFELISVI KEEAANRDGP MIVHDEHGGV TAGTFCALTT 1260

LMHQLEKENS VDVYQVAKMI NLMRPGVFAD IEQYQFLYKV ILSLVSTRQE ENPSTSLDSN 1320 GAALPDGNIA ESLESLV

Seq ID NO: 580 DNA sequence

Nucleic Acid Accession ft: EOS sequence

Coding sequence: 148-4632

1 11 21 31 41 51 1 I I I I I

CACACATACG CACGCACGAT CTCACTTCGA TCTATACACT GGAGGATTAA AACAAACAAA 60

CAAAAAAAAC ATTTCCTTCG CTCCCCCTCC CTCTCCACTC TGAGAAGCAG AGGAGCCGCA 120

CGGCGAGGGG CCGCAGACCG TCTGGAAATG CGAATCCTAA AACGTTTCCT CGCTTGCATT 180

CAGCTCCTCT GTGTTTGCCG CCTGGATTGG GCTAATGGAT ACTACAGACA ACAGAGAAAA 240

CTTGTTGAAG AGATTGGCTG GTCCTATACA GGAGCACTGA ATCAAAAAAA TTGGGGAAAG 300

AAATATCCAA CATGTAATAG CCCAAAACAA TCTCCTATCA ATATTGATGA AGATCTTACA 360

CAAGTAAATG TGAATCTTAA GAAACTTAAA TTTCAGGGTT GGGATAAAAC ATCATTGGAA 420

AACACATTCA TTCATAACAC TGGGAAAACA GTGGAAATTA ATCTCACTAA TGACTACCGT 480

GTCAGCGGAG GAGTTTCAGA AATGGTGTTT AAAGCAAGCA AGATAACTTT TCACTGGGGA 540

AAATGCAATA TGTCATCTGA TGGATCAGAG CATAGTTTAG AAGGACAAAA ATTTCCACTT 600

GAGATGCAAA TCTACTGCTT TGATGCGGAC CGATTTTCAA GTTTTGAGGA AGCAGTCAAA 660

GGAAAAGGGA AGTTAAGAGC TTTATCCATT TTGTTTGAGG TTGGGACAGA AGAAAATTTG 720

GATTTCAAAG CGATTATTGA TGGAGTCGAA AGTGTTAGTC GTTTTGGGAA GCAGGCTGCT 780

TTAGATCCAT TGATACTGTT GAACCTTCTG CCAAACTCAA CTGACAAGTA TTACATTTAC 840

AATGGCTCAT TGACATCTCC TCCCTGCACA GACACAGTTG ACTGGATTGT TTTTAAAGAT gOO

ACAGTTAGCA TCTCTGAAAG CCAGTTGGCT GTTTTTTGTG AAGTTCTTAC AATGCAACAA 960

TCTGGTTATG TCATGCTGAT GGACTACTTA CAAAACAATT TTCGAGAGCA ACAGTACAAG 1020

TTCTCTAGAC AGGTGTTTTC CTCATACACT GGAAAGGAAG AGATTCATGA AGCAGTTTGT 1080

AGTTCAGAAC CAGAAAATGT TCAGGCTGAC CCAGAGAATT ATACCAGCCT TCTTGTTACA 1140

TGGGAAAGAC CTCGAGTCGT TTATGATACC ATGATTGAGA AGTTTGCAGT TTTGTACCAG 1200

CAGTTGGATG GAGAGGACCA AACCAAGCAT GAATTTTTGA CAGATGGCTA TCAAGACTTG 1260

GGTGCTATTC TCAATAATTT GCTACCCAAT ATGAGTTATG TTCTTCAGAT AGTAGCCATA 1320

TGCACTAATG GCTTATATGG AAAATACAGC GACCAACTGA TTGTCGACAT GCCTACTGAT 1380

AATCCTGAAC TTGATCTTTT CCCTGAATTA ATTGGAACTG AAGAAATAAT CAAGGAGGAG 1440

GAAGAGGGAA AAGACATTGA AGAAGGCGCT ATTGTGAATC CTGGTAGAGA CAGTGCTACA 1500

AACCAAATCA GGAAAAAGGA ACCCCAGATT TCTACCACAA CACACTACAA TCGCATAGGG 1560

ACGAAATACA ATGAAGCCAA GACTAACCGA TCCCCAACAA GAGGAAGTGA ATTCTCTGGA 1620

AAGGGTGATG TTCCCAATAC ATCTTTAAAT TCCACTTCCC AACCAGTCAC TAAATTAGCC 1680

ACAGAAAAAG ATATTTCCTT GACTTCTCAG ACTGTGACTG AACTGCCACC TCACACTGTG 1740

GAAGGTACTT CAGCCTCTTT AAATGATGGC TCTAAAACTG TTCTTAGATC TCCACATATG 1800

AACTTGTCGG GGACTGCAGA ATCCTTAAAT ACAGTTTCTA TAACAGAATA TGAGGAGGAG 1860

AGTTTATTGA CCAGTTTCAA GCTTGATACT GGAGCTGAAG ATTCTTCAGG CTCCAGTCCC 1920

GCAACTTCTG CTATCCCATT CATCTCTGAG AACATATCCC AAGGGTATAT ATTTTCCTCC 1980

GAAAACCCAG AGACAATAAC ATATGATGTC CTTATACCAG AATCTGCTAG AAATGCTTCC 2040

GAAGATTCAA CTTCATCAGG TTCAGAAGAA TCACTAAAGG ATCCTTCTAT GGAGGGAAAT 2100

GTGTGGTTTC CTAGCTCTAC AGACATAACA GCACAGCCCG ATGTTGGATC AGGCAGAGAG 2160

AGCTTTCTCC AGACTAATTA CACTGAGATA CGTGTTGATG AATCTGAGAA GACAACCAAG 2220

TCCTTTTCTG CAGGCCCAGT GATGTCACAG GGTCCCTCAG TTACAGATCT GGAAATGCCA 2280

CATTATTCTA CCTTTGCCTA CTTCCCAACT GAGGTAACAC CTCATGCTTT TACCCCATCC 2340

TCCAGACAAC AGGATTTGGT CTCCACGGTC AACGTGGTAT ACTCGCAGAC AACCCAACCG 2400

GTATACAATG AGGCCAGTAA TAGTAGGCAT GAGTCTCGTA TTGGTCTAGC TGAGGGGTTG 2460

GAATCCGAGA AGAAGGCAGT TATACCCCTT GTGATCGTGT CAGCCCTGAC TTTTATCTGT 2520

CTAGTGGTTC TTGTGGGTAT TCTCATCTAC TGGAGGAAAT GCTTCCAGAC TGCACACTTT 2580

TACTTAGAGG ACAGTACATC CCCTAGAGTT ATATCCACAC CTCCAACACC TATCTTTCCA 2640

ATTTCAGATG ATGTCGGAGC AATTCCAATA AAGCACTTTC CAAAGCATGT TGCAGATTTA 2700

CATGCAAGTA GTGGGTTTAC TGAAGAATTT GAGACACTGA AAGAGTTTTA CCAGGAAGTG 2760

CAGAGCTGTA CTGTTGACTT AGGTATTACA GCAGACAGCT CCAACCACCC AGACAACAAG 2820

CACAAGAATC GATACATAAA TATCGTTGCC TATGATCATA GCAGGGTTAA GCTAGCACAG 2880

CTTGCTGAAA AGGATGGCAA ACTGACTGAT TATATCAATG CCAATTATGT TGATGGCTAC 2940

AACAGACCAA AAGCTTATAT TGCTGCCCAA GGCCCACTGA AATCCACAGC TGAAGATTTC 3000

TGGAGAATGA TATGGGAACA TAATGTGGAA GTTATTGTCA TGATAACAAA CCTCGTGGAG 3060

AAAGGAAGGA GAAAATGTGA TCAGTACTGG CCTGCCGATG GGAGTGAGGA GTACGGGAAC 3120

TTTCTGGΓCA CTCAGAAGAG TGTGCAAGTG CTΓGCCTATT AΓACTGΓGAG GAATTTTACT 3i80

CTAAGAAACA CAAAAATAAA AAAGGGCTCC CAGAAAGGAA GACCCAGTGG ACGTGTGGTC 3240

ACACAGTATC ACTACACGCA GTGGCCTGAC ATGGGAGTAC CAGAGTACTC CCTGCCAGTG 3300

CTGACCTTTG TGAGAAAGGC AGCCTATGCC AAGCGCCATG CAGTGGGGCC TGTTGTCGTC 3360

CACTGCAGTG CTGGAGTTGG AAGAACAGGC ACATATATTG TGCTAGACAG TATGTTGCAG 3420

CAGATTCAAC ACGAAGGAAC TGTCAACATA TTTGGCTTCT TAAAACACAT CCGTTCACAA 3480

AGAAATTATT TGGTACAAAC TGAGGAGCAA TATGTCTTCA TTCATGATAC ACTGGTTGAG 3540

GCCATACTTA GTAAAGAAAC TGAGGTGCTG GACAGTCATA TTCATGCCTA TGTTAATGCA 3600

CTCCTCATTC CTGGACCAGC AGGCAAAACA AAGCTAGAGA AACAATTCCA GGGTCTCACT 3660

CTGTCACCCA GGCTGGAGTG CAGAGGCACA ATCTCGGCTC ACTGCAACCT TCCTCTCCCT 3720

GGCTTAACTG ATCCTCCTAC CTCAGCCTCC CGAGTGGCTG GGACTATACT CCTGAGCCAG 3780

TCAAATATAC AGCAGAGTGA CTATTCTGCA GCCCTAAAGC AATGCAACAG GGAAAAGAAT 3840

CGAACTTCTT CTATCATCCC TGTGGAAAGA TCAAGGGTTG GCATTTCATC CCTGAGTGGA 3900

GAAGGCACAG ACTACATCAA TGCCTCCTAT ATCATGGGCT ATTACCAGAG CAATGAATTC 3960

ATCATTACCC AGCACCCTCT CCTTCATACC ATCAAGGATT TCTGGAGGAT GATATGGGAC 4020

CATAATGCCC AACTGGTGGT TATGATTCCT GATGGCCAAA ACATGGCAGA AGATGAATTT 4080

GTTTACTGGC CAAATAAAGA TGAGCCTATA AATTGTGAGA GCTTTAAGGT CACTCTTATG 4140

GCTGAAGAAC ACAAATGTCT ATCTAATGAG GAAAAACTTA TAATTCAGGA CTTTATCTTA 4200

GAAGCTACAC AGGATGATTA TGTACTTGAA GTGAGGCACT TTCAGTGTCC TAAATGGCCA 4260

AATCCAGATA GCCCCATTAG TAAAACTTTT GAACTTATAA GTGTTATAAA AGAAGAAGCT 4320

GCCAATAGGG ATGGGCCTAT GATTGTTCAT GATGAGCATG GAGGAGTGAC GGCAGGAACT 4380

TTCTGTGCTC TGACAACCCT TATGCACCAA CTAGAAAAAG AAAATTCCGT GGATGTTTAC 4440

CAGGTAGCCA AGATGATCAA TCTGATGAGG CCAGGAGTCT TTGCTGACAT TGAGCAGTAT 4500

CAGTTTCTCT ACAAAGTGAT CCTCAGCCTT GTGGGCACAA GGCAGGAAGA GAATCCATCC 4560

ACCTCTCTGG ACAGTAATGG TGCAGCATTG CCTGATGGAA ATATAGCTGA GAGCTTAGAG 4620

TCTTTAGTTT AACACAGAAA GGGGTGGGGG GACTCACATC TGAGCATTGT TTTCCTCTTC 4680

CTAAAATTAG GCAGGAAAAT CAGTCTAGTT CTGTTATCTG TTGATTTCCC ATCACCTGAC 4740

AGTAACTTTC ATGACATAGG ATTCTGCCGC CAAATTTATA TCATTAACAA TGTGTGCCTT 4800

TTTGCAAGAC TTGTAATTTA CTTATTATGT TTGAACTAAA ATGATTGAAT TTTACAGTAT 4860

TTCTAAGAAT GGAATTGTGG TATTTTTTTC TGTATTGATT TTAACAGAAA ATTTCAATTT 4920

ATAGAGGTTA GGAATTCCAA ACTACAGAAA ATGTTTGTTT TTAGTGTCAA ATTTTTAGCT 4980

GTATTTGTAG CAATTATCAG CTTTGCTAGA AATATAACTT TTAATACAGT AGCCTGTAAA 5040

TAAAACACTC TTCCATATGA TATTCAACAT TTTACAACTG CAGTATTCAC CTAAAGTAGA 5100

AATAATCTGT TACTTATTGT AAATACTGCC CTAGTGTCTC CATGGACCAA ATTTATATTT 5160 ATAATTGTAG ATTTTTATAT TTTACTACTG AGTCAAGTTT TCTAGTTCTG TGTAATTGTT 5220

TAGTTTAATG ACGTAGTTCA TTAGCTGGTC TTACTCTACC AGTTTTCTGA CATTGTATTG 5280

TGTTACCTAA GTCATTAACT TTGTTTCAGC ATGTAATTTT AACTTTTGTG GAAAATAGAA 5340

ATACCTTCAT TTTGAAAGAA GTTTTTATGA GAATAACACC TTACCAAACA TTGTTCAAAT 5400

GGTTTTTATC CAAGGAATTG CAAAAATAAA TATAAATATT GCCATTAAAA AAAAAAAAAA 5460 AAAAAAAAAA AAAAAAAAAA A

Seq ID NO: 581 Protein sequence: Protein Accession ft : EOS sequence

1 11 21 31 41 51

I I 1 I I I

MRILKRFLAC IQLLCVCRLD WANGYYRQQR KLVEEIGWSY TGALNQKNWG KKYPTCNSPK 60

QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 120

FKASKITFHW GKCNMSSDGS EHSLEGQKFP LEMQIYCFDA DRFSSFEEAV KGKGKLRALS 180

ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 240

TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 300

TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPR YD TMIEKFAVLY QQLDGEDQTK 360

HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY SDQLIVDMPT DNPELDLFPE 420

LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 480

RSPTRGSEFS GKGDVPNTSL NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND 540

GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS 600

ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG NVWFPSSTDI 660

TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 720

TEVTPHAFTP SSRQQDLVST VNWYSQTTQ PVYNEASNSS HESRIGLAEG LESEKKAVIP 780

LVIVSALTFI CLWLVGILI YWRKCFQTAH FYLEDSTSPR VISTPPTPIF PISDDVGAIP 840

IKHFPKHVAD LHASSGFTEE FETLKEFYQE VQSCTVDLGI TADSSNHPDN KHKNRYINIV 900

AYDHSRVKLA QLAEKDGKLT DYINANYVDG YNRPKAYIAA QGPLKSTAED FWRMIWEHNV 960

EVIVMITNLV EKGRRKCDQY WPADGSEEYG NFLVTQKSVQ VLAYYTVRNF TLRNTKIKKG 1020

SQKGRPSGRV VTQYHYTQWP DMGVPEYSLP VLTFVRKAAY AKRHAVGPW VHCSAGVGRT 1080

GTYIVLDSML QQIQHEGTVN IFGFLKHIRS QRNYLVQTEE QYVFIHDTLV EAILSKETEV 1140

LDSHIHAYVN ALLIPGPAGK TKLEKQFQGL TLSPRLECRG TISAHCNLPL PGLTDPPTSA 1200

SRVAGTILLS QSNIQQSDYS AALKQCNREK NRTSSIIPVE RSRVGISSLS GEGTDYINAS 1260

YIMGYYQSNE FIITQHPLLH TIKDFWRMIW DHNAQLWMI PDGQNMAEDE FVYWPNKDEP 1320

INCESFKVTL MAEEHKCLSN EEKLIIQDFI LEATQDDYVL EVRHFQCPKW PNPDSPISKT 1380

FELISVIKEE AANRDGPMIV HDEHGGVTAG TFCALTTLMH QLEKENSVDV YQVAKMINLM 1440 RPGVFADIEQ YQFLYKVILS LVGTRQEENP STSLDSNGAA LPDGNIAESL ESLV

Seq ID NO: 582 DNA sequence

Nucleic Acid Accession ft: NM_002851.1

Coding sequence: 148..7092

1 11 21 31 41 51 i i i i i i

CACACATACG CACGCACGAT CTCACTTCGA TCTATACACT GGAGGATTAA AACAAACAAA 60

CAAAAAAAAC ATTTCCTTCG CTCCCCCTCC CTCTCCACTC TGAGAAGCAG AGGAGCCGCA 120

CGGCGAGGGG CCGCAGACCG TCTGGAAATG CGAATCCTAA AGCGTTTCCT CGCTTGCATT 180

CAGCTCCTCT GTGTTTGCCG CCTGGATTGG GCTAATGGAT ACTACAGACA ACAGAGAAAA 240

CTTGTTGAAG AGATTGGCTG GTCCTATACA GGAGCACTGA ATCAAAAAAA TTGGGGAAAG 300

AAATATCCAA CATGTAATAG CCCAAAACAA TCTCCTATCA ATATTGATGA AGATCTTACA 360

CAAGTAAATG TGAATCTTAA GAAACTTAAA TTTCAGGGTT GGGATAAAAC ATCATTGGAA 420

AACACATTCA TTCATAACAC TGGGAAAACA GTGGAAATTA ATCTCACTAA TGACTACCGT 480

GTCAGCGGAG GAGTTTCAGA AATGGTGTTT AAAGCAAGCA AGATAACTTT TCACTGGGGA 540

AAATGCAATA TGTCATCTGA TGGATCAGAG CATAGTTTAG AAGGACAAAA ATTTCCACTT 600

GAGATGCAAA TCTACTGCTT TGATGCGGAC CGATTTTCAA GTTTTGAGGA AGCAGTCAAA 660

GGAAAAGGGA AGTTAAGAGC TTTATCCATT TTGTTTGAGG TTGGGACAGA AGAAAATTTG 720

GATTTCAAAG CGATTATTGA TGGAGTCGAA AGTGTTAGTC GTTTTGGGAA GCAGGCTGCT 780

TTAGATCCAT TCATACTGTT GAACCTTCTG CCAAACTCAA CTGACAAGTA TTACATTTAC 840

AATGGCTCAT TGACATCTCC TCCCTGCACA GACACAGTTG ACTGGATTGT TTTTAAAGAT 900

ACAGTTAGCA TCTCTGAAAG CCAGTTGGCT GTTTTTTGTG AAGTTCTTAC AATGCAACAA 960

TCTGGTTATG TCATGCTGAT GGACTACTTA CAAAACAATT TTCGAGAGCA ACAGTACAAG 1020

TTCTCTAGAC AGGTGTTTTC CTCATACACT GGAAAGGAAG AGATTCATGA AGCAGTTTGT 1080

AGTTCAGAAC CAGAAAATGT TCAGGCTGAC CCAGAGAATT ATACCAGCCT TCTTGTTACA 1140

TGGGAAAGAC CTCGAGTCGT TTATGATACC ATGATTGAGA AGTTTGCAGT TTTGTACCAG 1200

CAGTTGGATG GAGAGGACCA AACCAAGCAT GAATTTTTGA CAGATGGCTA TCAAGACTTG 1260

GGTGCTATTC TCAATAATTT GCTACCCAAT ATGAGTTATG TTCTTCAGAT AGTAGCCATA 1320

TGCACTAATG GCTTATATGG AAAATACAGC GACCAACTGA TTGTCGACAT GCCTACTGAT 1380

AATCCTGAAC TTGATCTTTT CCCTGAATTA ATTGGAACTG AAGAAATAAT CAAGGAGGAG 1440

GAAGAGGGAA AAGACATTGA AGAAGGCGCT ATTGTGAATC CTGGTAGAGA CAGTGCTACA 1500

AACCAAATCA GGAAAAAGGA ACCCCAGATT TCTACCACAA CACACTACAA TCGCATAGGG 1560

ACGAAATACA ATGAAGCCAA GACTAACCGA TCCCCAACAA GAGGAAGTGA ATTCTCTGGA 1620

AAGGGTGATG TTCCCAATAC ATCTTTAAAT TCCACTTCCC AACCAGTCAC TAAATTAGCC 1680

ACAGAAAAAG ATATTTCCTT GACTTCTCAG ACTGTGACTG AACTGCCACC TCACACTGTG 1740

GAAGGTACTT CAGCCTCTTT AAATGATGGC TCTAAAACTG TTCTTAGATC TCCACATATG 1800

AACTTGTCGG GGACTGCAGA ATCCTTAAAT ACAGTTTCTA TAACAGAATA TGAGGAGGAG 1860

AGTTTATTGA CCAGTTTCAA GCTTGATACT GGAGCTGAAG ATTCTTCAGG CTCCAGTCCC 1920

GCAACTTCTG CTATCCCATT CATCTCTGAG AACATATCCC AAGGGTATAT ATTTTCCTCC 1980

GAAAACCCAG AGACAATAAC ATATGATGTC CTTATACCAG AATCTGCTAG AAATGCTTCC 2040 GAAGATTCAA CTTCATCAGG TTCAGAAGAA TCACTAAAGG ATCCTTCTAT GGAGGGAAAT 2100

GTGTGGTTTC CTAGCTCTAC AGACATAACA GCACAGCCCG ATGTTGGATC AGGCAGAGAG 2160

AGCTTTCTCC AGACTAATTA CACTGAGATA CGTGTTGATG AATCTGAGAA GACAACCAAG 2220

TCCTTTTCTG CAGGCCCAGT GATGTCACAG GGTCCCTCAG TTACAGATCT GGAAATGCCA 2280

CATTATTCTA CCTTTGCCTA CTTCCCAACT GAGGTAACAC CTCATGCTTT TACCCCATCC 2340

TCCAGACAAC AGGATTTGGT CTCCACGCTC AACGTGGTAT ACTCGCAGAC AACCCAACCG 2400

GTATACAATG GTGAGACACC TCTTCAACCT TCCTACAGTA GTGAAGTCTT TCCTCTAGTC 2460

ACCCCTTTGT TGCTTGACAA TCAGATCCTC AACACTACCC CTGCTGCTTC AAGTAGTGAT 2520 TCGGCCTTGC ATGCTACGCC TGTATTTCCC AGTGTCGATG TGTCATTTGA ATCCATCCTG 2580 TCTTCCTATG ATGGTGCACC TTTGCTTCCA TTTTCCTCTG CTTCCTTCAG TAGTGAATTG 2640 TTTCGCCATC TGCATACAGT TTCTCAAATC CTTCCACAAG TTACTTCAGC TACCGAGAGT 2700 GATAAGGTGC CCTTGCATGC TTCTCTGCCA GTGGCTGGGG GTGATTTGCT ATTAGAGCCC 2760 AGCCTTGCTC AGTATTCTGA TGTGCTGTCC ACTACTCATG CTGCTTCAGA GACGCTGGAA 2820 TTTGGTAGTG AATCTGGTGT TCTTTATAAA ACGCTTATGT TTTCTCAAGT TGAACCACCC 2880 AGCAGTGATG CCATGATGCA TGCACGTTCT TCAGGGCCTG AACCTTCTTA TGCCTTGTCT 2940 GATAATGAGG GCTCCCAACA CATCTTCACT GTTTCTTACA GTTCTGCAAT ACCTGTGCAT 3000 GATTCTGTGG GTGTAACTTA TCAGGGTTCC TTATTTAGCG GCCCTAGCCA TATACCAATA 3060 CCTAAGTCTT CGTTAATAAC CCCAACTGCA TCATTACTGC AGCCTACTCA TGCCCTCTCT 3120 GGTGATGGGG AATGGTCTGG AGCCTCTTCT GATAGTGAAT TTCTTTTACC TGACACAGAT 3180 GGGCTGACAG CCCTTAACAT TTCTTCACCT GTTTCTGTAG CTGAATTTAC ATATACAACA 3240 TCTGTGTTTG GTGATGATAA TAAGGCGCTT TCTAAAAGTG AAATAATATA TGGAAATGAG 3300 ACTGAACTGC AAATTCCTTC TTTCAATGAG ATGGTTTACC CTTCTGAAAG CACAGTCATG 3360 CCCAACATGT ATGATAATGT AAATAAGTTG AATGCGTCTT TACAAGAAAC CTCTGTTTCC 3420 ATTTCTAGCA CCAAGGGCAT GTTTCCAGGG TCCCTTGCTC ATACCACCAC TAAGGTTTTT 3480 GATCATGAGA TTAGTCAAGT TCCAGAAAAT AACTTTTCAG TTCAACCTAC ACATACTGTC 3540 TCTCAAGCAT CTGGTGACAC TTCGCTTAAA CCTGTGCTTA GTGCAAACTC AGAGCCAGCA 3600 TCCTCTGACC CTGCTTCTAG TGAAATGTTA TCTCCTTCAA CTCAGCTCTT ATTTTATGAG 3660 ACCTCAGCTT CTTTTAGTAC TGAAGTATTG CTACAACCTT CCTTTCAGGC TTCTGATGTT 3720 GACACCTTGC TTAAAACTGT TCTTCCAGCT GTGCCCAGTG ATCCAATATT GGTTGAAACC 3780 CCCAAAGTTG ATAAAATTAG TTCTACAATG TTGCATCTCA TTGTATCAAA TTCTGCTTCA 3840 AGTGAAAACA TGCTGCACTC TACATCTGTA CCAGTTTTTG ATGTGTCGCC TACTTCTCAT 3900 ATGCACTCTG CTTCACTTCA AGGTTTGACC ATTTCCTATG CAAGTGAGAA ATATGAACCA 3960 GTTTTGTTAA AAAGTGAAAG TTCCCACCAA GTGGTACCTT CTTTGTACAG TAATGATGAG 4020 TTGTTCCAAA CGGCCAATTT GGAGATTAAC CAGGCCCATC CCCCAAAAGG AAGGCATGTA 4080 TTTGCTACAC CTGTTTTATC AATTGATGAA CCATTAAATA CACTAATAAA TAAGCTTATA 4140 CATTCCGATG AAATTTTAAC CTCCACCAAA AGTTCTGTTA CTGGTAAGGT ATTTGCTGGT 4200 ATTCCAACAG TTGCTTCTGA TACATTTGTA TCTACTGATC ATTCTGTTCC TATAGGAAAT 4260 GGGCATGTTG CCATTACAGC TGTTTCTCCC CACAGAGATG GTTCTGTAAC CTCAACAAAG 4320 TTGCTGTTTC CTTCTAAGGC AACTTCTGAG CTGAGTCATA GTGCCAAATC TGATGCCGGT 4380 TTAGTGGGTG GTGGTGAAGA TGGTGACACT GATGATGATG GTGATGATGA TGATGACAGA 4440 GATAGTGATG GCTTATCCAT TCATAAGTGT ATGTCATGCT CATCCTATAG AGAATCACAG 4500 GAAAAGGTAA TGAATGATTC AGACACCCAC GAAAACAGTC TTATGGATCA GAATAATCCA 4560 ATCTCATACT CACTATCTGA GAATTCTGAA GAAGATAATA GAGTCACAAG TGTATCCTCA 4620 GACAGTCAAA CTGGTATGGA CAGAAGTCCT GGTAAATCAC CATCAGCAAA TGGGCTATCC 4680 CAAAAGCACA ATGATGGAAA AGAGGAAAAT GACATTCAGA CTGGTAGTGC TCTGCTTCCT 4740 CTCAGCCCTG AATCTAAAGC ATGGGCAGTT CTGACAAGTG ATGAAGAAAG TGGATCAGGG 4800 CAAGGTACCT CAGATAGCCT TAATGAGAAT GAGACTTCCA CAGATTTCAG TTTTGCAGAC 4860 ACTAATGAAA AAGATGCTGA TGGGATCCTG GCAGCAGGTG ACTCAGAAAT AACTCCTGGA 4920 TTCCCACAGT CCCCAACATC ATCTGTTACT AGCGAGAACT CAGAAGTGTT CCACGTTTCA 4980 GAGGCAGAGG CCAGTAATAG TAGCCATGAG TCTCGTATTG GTCTAGCTGA GGGGTTGGAA 5040 TCCGAGAAGA AGGCAGTTAT ACCCCTTGTG ATCGTGTCAG CCCTGACTTT TATCTGTCTA 5100 GTGGTTCTTG TGGGTATTCT CATCTACTGG AGGAAATGCT TCCAGACTGC ACACTTTTAC 5160 TTAGAGGACA GTACATCCCC TAGAGTTATA TCCACACCTC CAACACCTAT CTTTCCAATT 5220 TCAGATGATG TCGGAGCAAT TCCAATAAAG CACTTTCCAA AGCATGTTGC AGATTTACAT 5280 GCAAGTAGTG GGTTTACTGA AGAATTTGAG ACACTGAAAG AGTTTTACCA GGAAGTGCAG 5340 AGCTGTACTG TTGACTTAGG TATTACAGCA GACAGCTCCA ACCACCCAGA CAACAAGCAC 5400 AAGAATCGAT ACATAAATAT CGTTGCCTAT GATCATAGCA GGGTTAAGCT AGCACAGCTT 5460 GCTGAAAAGG ATGGCAAACT GACTGATTAT ATCAATGCCA ATTATGTTGA TGGCTACAAC 5520 AGACCAAAAG CTTATATTGC TGCCCAAGGC CCACTGAAAT CCACAGCTGA AGATTTCTGG 5580 AGAATGATAT GGGAACATAA TGTGGAAGTT ATTGTCATGA TAACAAACCT CGTGGAGAAA 5640 GGAAGGAGAA AATGTGATCA GTACTGGCCT GCCGATGGGA GTGAGGAGTA CGGGAACTTT 5700 CTGGTCACTC AGAAGAGTGT GCAAGTGCTT GCCTATTATA CTGTGAGGAA TTTTACTCTA 5760 AGAAACACAA AAATAAAAAA GGGCTCCCAG AAAGGAAGAC CCAGTGGACG TGTGGTCACA 5820 CAGTATCACT ACACGCAGTG GCCTGACATG GGAGTACCAG AGTACTCCCT GCCAGTGCTG 5880 ACCTTTGTGA GAAAGGCAGC CTATGCCAAG CGCCATGCAG TGGGGCCTGT TGTCGTCCAC 5940 TGCAGTGCTG GAGTTGGAAG AACAGGCACA TATATTGTGC TAGACAGTAT GTTGCAGCAG 6000 ATTCAACACG AAGGAACTGT CAACATATTT GGCTTCTTAA AACACATCCG TTCACAAAGA 6060 AATTATTTGG TACAAACTGA GGAGCAATAT GTCTTCATTC ATGATACACT GGTTGAGGCC 6120 ATACTTAGTA AAGAAACTGA GGTGCTGGAC AGTCATATTC ATGCCTATGT TAATGCACTC 6180 CTCATTCCTG GACCAGCAGG CAAAACAAAG CTAGAGAAAC AATTCCAGCT CCTGAGCCAG 6240 TCAAATATAC AGCAGAGTGA CTATTCTGCA GCCCTAAAGC AATGCAACAG GGAAAAGAAT 6300 CGAACTTCTT CTATCATCCC TGTGGAAAGA TCAAGGGTTG GCATTTCATC CCTGAGTGGA 6360 GAAGGCACAG ACTACATCAA TGCCTCCTAT ATCATGGGCT ATTACCAGAG CAATGAATTC 6420 ATCATTACCC AGCACCCTCT CCTTCATACC ATCAAGGATT TCTGGAGGAT GATATGGGAC 6480 CATAATGCCC AACTGGTGGT TATGATTCCT GATGGCCAAA ACATGGCAGA AGATGAATTT 6540 GTTTACTGGC CAAATAAAGA TGAGCCTATA AATTGTGAGA GCTTTAAGGT CACTCTTATG 6600 GCTGAAGAAC ACAAATGTCT ATCTAATGAG GAAAAACTTA TAATTCAGGA CTTTATCTTA 6660 GAAGCTACAC AGGATGATTA TGTACTTGAA GTGAGGCACT TTCAGTGTCC TAAATGGCCA 6720 AATCCAGATA GCCCCATTAG TAAAACTTTT GAACTTATAA GTGTTATAAA AGAAGAAGCT 6780 GCCAATAGGG ATGGGCCTAT GATTGTTCAT GATGAGCATG GAGGAGTGAC GGCAGGAACT 6840 TTCTGTGCTC TGACAACCCT TATGCACCAA CTAGAAAAAG AAAATTCCGT GGATGTTTAC 6900 CAGGTAGCCA AGATGATCAA TCTGATGAGG CCAGGAGTCT TTGCTGACAT TGAGCAGTAT 6960 CAGTTTCTCT ACAAAGTGAT CCTCAGCCTT GTGAGCACAA GGCAGGAAGA GAATCCATCC 7020 ACCTCTCTGG ACAGTAATGG TGCAGCATTG CCTGATGGAA ATATAGCTGA GAGCTTAGAG 7080 TCTTTAGTTT AACACAGAAA GGGGTGGGGG GACTCACATC TGAGCATTGT TTTCCTCTTC 7140 CTAAAATTAG GCAGGAAAAT CAGTCTAGTT CTCTTATCTG TTGATTTCCC ATCACCTGAC 7200 AGTAACTTTC ATGACATAGG ATTCTGCCGC CAAATTTATA TCATTAACAA TGTGTGCCTT 7260 TTTGCAAGAC TTGTAATTTA CTTATTATGT TTGAACTAAA ATGATTGAAT TTTACAGTAT 7320 TTCTAAGAAT GGAATTGTGG TATTTTTTTC TGTATTGATT TTAACAGAAA ATTTCAATTT 7380 ATAGAGGTTA GGAATTCCAA ACTACAGAAA ATGTTTGTTT TTAGTGTCAA ATTTTTAGCT 7440 GTATTTGTAG CAATTATCAG GTTTGCTAGA AATATAACTT TTAATACAGT AGCCTGTAAA 7500 TAAAACACTC TTCCATATGA TATTCAACAT TTTACAACTG CAGTATTCAC CTAAAGTAGA 7560 AATAATCTGT TACTTATTGT AAATACTGCC CTAGTGTCTC CATGGACCAA ATTTATATTT 7620 ATAATTGTAG ATTTTTATAT TTTACTACTG AGTCAAGTTT TCTAGTTCTG TGTAATTGTT 7680 TAGTTTAATG ACGTAGTTCA TTAGCTGGTC TTACTCTACC AGTTTTCTGA CATTGTATTG 7740 TGTTACCTAA GTCATTAACT TTGTTTCAGC ATGTAATTTT AACTTTTGTG GAAAATAGAA 7800

ATACCTTCAT TTTGAAAGAA GTTTTTATGA GAATAACACC TTACCAAACA TTGTTCAAAT 7860

GGTTTTTATC CAAGGAATTG CAAAAATAAA TATAAATATT GCCATTAAAA AAAAAAAAAA 7920 AAAAAAAAAA AAAAAAAAAA A

Seq ID NO: 583 Protein sequence Protein Accession ft: NP 002842.1

11 21 31 41 51

I I I I

MRILKRFLAC IQLLCVCRLD WANGYYRQQR KLVEEIGWSY TGALNQKNWG KKYPTCNSPK 60 QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 120 FKASKITFHW GKCNMSSDGS EHSLEGQKFP LEMQIYCFDA DRFSSFEEAV KGKGKLRALS 180 ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 240 TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 300 TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPRWYD TMIEKFAVLY QQLDGEDQTK 360 HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY SDQ IVDMPT DNPELDLFPE 420 LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 480 RSPTRGSEFS GKGDVPNTSL NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND 540 GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS 600 ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG NVWFPSSTDI 660 TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 720 TEVTPHAFTP SSRQQDLVST VNWYSQTTQ PVYNGETPLQ PSYSSEVFPL VTPLLLDNQI 780 LNTTPAASSS DSALHATPVF PSVDVSFESI LSSYDGAPLL PFSSASFSSE LFRHLHTVSQ 840 ILPQVTSATE SDKVPLHASL PVAGGDLLLE PSLAQYSDVL STTHAASETL EFGSESGVLY 900 KTLMFSQVEP PSSDAMMHAR SSGPEPSYAL SDNEGSQHIF TVS SSAIPV HDSVGVTYQG 960 SLFSGPSHIP IPKSSLITPT ASLLQPTHAL SGDGEWSGAS SDSEFLLPDT DGLTALNISS 1020 PVSVAEFTYT TSVFGDDNKA LSKSEIIYGN ETELQIPSFN EMVYPSESTV MPNMYDNVNK 1080 LNASLQETSV SISSTKGMFP GSLAHTTTKV FDHEISQVPE NNFSVQPTHT VSQASGDTSL 1140 KPVLSANSEP ASSDPASSEM LSPSTQLLFY ETSASFSTEV LLQPSFQASD VDTLLKTVLP 1200 AVPSDPILVE TPKVDKISST MLHLIVSNSA SSENMLHSTS VPVFDVSPTS HMHSASLQGL 1260 TISYASEKYE PVLLKSESSH QWPSLYSND ELFQTANLEI NQAHPPKGRH VFATPVLSID 1320 EPLNTLINKL IHSDEILTST KSSVTGKVFA GIPTVASDTF VSTDHSVPIG NGHVAITAVS 1380 PHRDGSVTST KLLFPSKATS ELSHSAKSDA GLVGGGEDGD TDDDGDDDDD RDSDGLSIHK 1440 CMSCSSYRES QEKVMNDSDT HENSLMDQNN PISYSLSENS EEDNRVTSVS SDSQTGMDRS 1500 PGKSPSANGL SQKHNDGKEE NDIQTGSALL PLSPESKAWA VLTSDEESGS GQGTSDSLNE 1560 NETSTDFSFA DTNEKDADGI LAAGDSEITP GFPQSPTSSV TSENSEVFHV SEAEASNSSH 1620 ESRIGLAEGL ESEKKAVIPL VIVSALTFIC LWLVGILIY WRKCFQTAHF YLEDSTSPRV 1680 ISTPPTPIFP ISDDVGAIPI KHFPKHVADL HASSGFTEEF ETLKEFYQEV QSCTVDLGIT 1740 ADSSNHPDNK HKNRYINIVA YDHSRVKLAQ LAEKDGKLTD YINANYVDGY NRPKAYIAAQ 1800 GPLKSTAEDF WRMIWEHNVE VIVMITNLVE KGRRKCDQYW PADGSEEYGN FLVTQKSVQV 1860 LAYYTVRNFT LRNTKIKKGS QKGRPSGRW TQYHYTQWPD MGVPEYSLPV LTFVRKAAYA 1920 KRHAVGPVW HCSAGVGRTG TYIVLDSMLQ QIQHEGTVNI FGFLKHIRSQ RNYLVQTEEQ 1980 YVFIHDTLVE AILSKETEVL DSHIHAYVNA LLIPGPAGKT KLEKQFQLLS QSNIQQSDYS 2040 AALKQCNREK NRTSSIIPVE RSRVGISSLS GEGTDYINAS YIMGYYQSNE FIITQHPLLH 2100 TIKDFWRMIW DHNAQLWMI PDGQNMAEDE FVYWPNKDEP INCESFKVTL MAEEHKCLSN 2160 EEKLIIQDFI LEATQDDYVL EVRHFQCPKW PNPDSPISKT FELISVIKEE AANRDGPMIV 2220 HDEHGGVTAG TFCALTTLMH QLEKENSVDV YQVAKMINLM RPGVFADIEQ YQFLYKVILS 2280 LVSTRQEENP STSLDSNGAA LPDGNIAESL ESLV

Seq ID NO: 584 DNA sequence

Nucleic Acid Accession ft: NM_005688.1

Coding sequence: 126..4439

11 21 31 41 51

CCGGGCAGGT GGCTCATGCT CGGGAGCGTG GTTGAGCGGC TGGCGCGGTT GTCCTGGAGC 60 AGGGGCGCAG GAATTCTGAT GTGAAACTAA CAGTCTGTGA GCCCTGGAAC CTCCGCTCAG 120 AGAAGATGAA GGATATCGAC ATAGGAAAAG AGTATATCAT CCCCAGTCCT GGGTATAGAA 180 GTGTGAGGGA GAGAACCAGC ACTTCTGGGA CGCACAGAGA CCGTGAAGAT TCCAAGTTCA 240 GGAGAACΓCG ACCGTTGGAA TGCCAAGATG CCTTGGAAAC AGCAGCCCGA GCCGAGGGCC 300

TCTCTCTTGA TGCCTCCATG CATTCTCAGC TCAGAATCCT GGATGAGGAG CATCCCAAGG 360 GAAAGTACCA TCATGGCTTG AGTGCTCTGA AGCCCATCCG GACTACTTCC AAACACCAGC 420 ACCCAGTGGA CAATGCTGGG CTTTTTTCCT GTATGACTTT TTCGTGGCTT TCTTCTCTGG 480 CCCGTGTGGC CCACAAGAAG GGGGAGCTCT CAATGGAAGA CGTGTGGTCT CTGTCCAAGC 540 ACGAGTCTTC TGACGTGAAC TGCAGAAGAC TAGAGAGACT GTGGCAAGAA GAGCTGAATG 600 AAGTTGGGCC AGACGCTGCT TCCCTGCGAA GGGTTGTGTG GATCTTCTGC CGCACCAGGC 660 TCATCCTGTC CATCGTGTGC CTGATGATCA CGCAGCTGGC TGGCTTCAGT GGACCAGCCT 720 TCATGGTGAA ACACCTCTTG GAGTATACCC AGGCAACAGA GTCTAACCTG CAGTACAGCT 780 TGTTGTTAGT GCTGGGCCTC CTCCTGACGG AAATCGTGCG GTCTTGGTCG CTTGCACTGA 840 CTTGGGCATT GAATTACCGA ACCGGTGTCC GCTTGCGGGG GGCCATCCTA ACCATGGCAT 900 TTAAGAAGAT CCTTAAGTTA AAGAACATTA AAGAGAAATC CCTGGGTGAG CTCATCAACA 960 TTTGCTCCAA CGATGGGCAG AGAATGTTTG AGGCAGCAGC CGTTGGCAGC CTGCTGGCTG 1020 GAGGACCCGT TGTTGCCATC TTAGGCATGA TTTATAATGT AATTATTCTG GGACCAACAG 1080 GCTTCCTGGG ATCAGCTGTT TTTATCCTCT TTTACCCAGC AATGATGTTT GCATCACGGC 1140 TCACAGCATA TTTCAGGAGA AAATGCGTGG CCGCCACGGA TGAACGTGTC CAGAAGATGA 1200 ATGAAGTTCT TACTTACATT AAATTTATCA AAATGTATGC CTGGGTCAAA GCATTTTCTC 1260 AGAGTGTTCA AAAAATCCGC GAGGAGGAGC GTCGGATATT GGAAAAAGCC GGGTACTTCC 1320 AGGGTATCAC TGTGGGTGTG GCTCCCATTG TGGTGGTGAT TGCCAGCGTG GTGACCTTCT 1380 CTGTTCATAT GACCCTGGGC TTCGATCTGA CAGCAGCACA GGCTTTCACA GTGGTGACAG 1440 TCTTCAATTC CATGACTTTT GCTTTGAAAG TAACACCGTT TTCAGTAAAG TCCCTCTCAG 1500 AAGCCTCAGT GGCTGTTGAC AGATTTAAGA GTTTGTTTCT AATGGAAGAG GTTCACATGA 1560 TAAAGAACAA ACCAGCCAGT CCTCACATCA AGATAGAGAT GAAAAATGCC ACCTTGGCAT 1620 GGGACTCCTC CCACTCCAGT ATCCAGAACT CGCCCAAGCT GACCCCCAAA ATGAAAAAAG 1680 ACAAGAGGGC TTCCAGGGGC AAGAAAGAGA AGGTGAGGCA GCTGCAGCGC ACTGAGCATC 1740 AGGCGGTGCT GGCAGAGCAG AAAGGCCACC TCCTCCTGGA CAGTGACGAG CGGCCCAGTC 1800 CCGAAGAGGA AGAAGGCAAG CACATCCACC TGGGCCACCT GCGCTTACAG AGGACACTGC 1860 ACAGCATCGA TCTGGAGATC CAAGAGGGTA AACTGGTTGG AATCTGCGGC AGTGTGGGAA 1920

GTGGAAAAAC CTCTCTCATT TCAGCCATTT TAGGCCAGAT GACGCTTCTA GAGGGCAGCA 1980

TTGCAATCAG TGGAACCTTC GCTTATGTGG CCCAGCAGGC CTGGATCCTC AATGCTACTC 2040

TGAGAGACAA CATCCTGTTT GGGAAGGAAT ATGATGAAGA AAGATACAAC TCTGTGCTGA 2100 ACAGCTGCTG CCTGAGGCCT GACCTGGCCA TTCTTCCCAG CAGCGACCTG ACGGAGATTG 2160

GAGAGCGAGG AGCCAACCTG AGCGGTGGGC AGCGCCAGAG GATCAGCCTT GCCCGGGCCT 2220

TGTATAGTGA CAGGAGCATC TACATCCTGG ACGACCCCCT CAGTGCCTTA GATGCCCATG 2280

TGGGCAACCA CATCTTCAAT AGTGCTATCC GGAAACATCT CAAGTCCAAG ACAGTTCTGT 2340

TTGTTACCCA CCAGTTACAG TACCTGGTTG ACTGTGATGA AGTGATCTTC ATGAAAGAGG 2400 GCTGTATTAC GGAAAGAGGC ACCCATGAGG AACTGATGAA TTTAAATGGT GACTATGCTA 2460

CCATTTTTAA TAACCTGTTG CTGGGAGAGA CACCGCCAGT TGAGATCAAT TCAAAAAAGG 2520

AAACCAGTGG TTCACAGAAG AAGTCACAAG ACAAGGGTCC TAAAACAGGA TCAGTAAAGA 2580

AGGAAAAAGC AGTAAAGCCA GAGGAAGGGC AGCTTGTGCA GCTGGAAGAG AAAGGGCAGG 2640

GTTCAGTGCC CTGGTCAGTA TATGGTGTCT ACATCCAGGC TGCTGGGGGC CCCTTGGCAT 2700 TCCTGGTTAT TATGGCCCTT TTCATGCTGA ATGTAGGCAG CACCGCCTTC AGCACCTGGT 2760

GGTTGAGTTA CTGGATCAAG CAAGGAAGCG GGAACACCAC TGTGACTCGA GGGAACGAGA 2820

CCTCGGTGAG TGACAGCATG AAGGACAATC CTCATATGCA GTACTATGCC AGCATCTACG 2880

CCCTCTCCAT GGCAGTCATG CTGATCCTGA AAGCCATTCG AGGAGTTGTC TTTGTCAAGG 2940

GCACGCTGCG AGCTTCCTCC CGGCTGCATG ACGAGCTTTT CCGAAGGATC CTTCGAAGCC 3000 CTATGAAGTT TTTTGACACG ACCCCCACAG GGAGGATTCT CAACAGGTTT TCCAAAGACA 3060

TGGATGAAGT TGACGTGCGG CTGCCGTTCC AGGCCGAGAT GTTCATCCAG AACGTTATCC 3120

TGGTGTTCTT CTGTGTGGGA ATGATCGCAG GAGTCTTCCC GTGGTTCCTT GTGGCAGTGG 3180

GGCCCCTTGT CATCCTCTTT TCAGTCCTGC ACATTGTCTC CAGGGTCCTG ATTCGGGAGC 3240

TGAAGCGTCT GGACAATATC ACGCAGTCAC CTTTCCTCTC CCACATCACG TCCAGCATAC 3300 AGGGCCTTGC CACCATCCAC GCCTACAATA AAGGGCAGGA GTTTCTGCAC AGATACCAGG 3360

AGCTGCTGGA TGACAACCAA GCTCCTTTTT TTTTGTTTAC GTGTGCGATG CGGTGGCTGG 3420

CTGTGCGGCT GGACCTCATC AGCATCGCCC TCATCACCAC CACGGGGCTG ATGATCGTTC 3480

TTATGCACGG GCAGATTCCC CCAGCCTATG CGGGTCTCGC CATCTCTTAT GCTGTCCAGT 3540

TAACGGGGCT GTTCCAGTTT ACGGTCAGAC TGGCATCTGA GACAGAAGCT CGATTCACCT 3600 CGGTGGAGAG GATCAATCAC TACATTAAGA CTCTGTCCTT GGAAGCACCT GCCAGAATTA 3660

AGAACAAGGC TCCCTCCCCT GACTGGCCCC AGGAGGGAGA GGTGACCTTT GAGAACGCAG 3720

AGATGAGGTA CCGAGAAAAC CTCCCTCTTG TCCTAAAGAA AGTATCCTTC ACGATCAAAC 3780

CTAAAGAGAA GATTGGCATT GTGGGGCGGA CAGGATCAGG GAAGTCCTCG CTGGGGATGG 3840

CCCTCTTCCG TCTGGTGGAG TTATCTGGAG GCTGCATCAA GATTGATGGA GTGAGAATCA 3900 GTGATATTGG CCTTGCCGAC CTCCGAAGCA AACTCTCTAT CATTCCTCAA GAGCCGGTGC 3960

TGTTCAGTGG CACTGTCAGA TCAAATTTGG ACCCCTTCAA CCAGTACACT GAAGACCAGA 4020

TTTGGGATGC CCTGGAGAGG ACACACATGA AAGAATGTAT TGCTCAGCTA CCTCTGAAAC 4080

TTGAATCTGA AGTGATGGAG AATGGGGATA ACTTCTCAGT GGGGGAACGG CAGCTCTTGT 4140

GCATAGCTAG AGCCCTGCTC CGCCACTGTA AGATTCTGAT TTTAGATGAA GCCACAGCTG 4200 CCATGGACAC AGAGACAGAC TTATTGATTC AAGAGACCAT CCGAGAAGCA TTTGCAGACT 4260

GTACCATGCT GACCATTGCC CATCGCCTGC ACACGGTTCT AGGCTCCGAT AGGATTATGG 4320

TGCTGGCCCA GGGACAGGTG GTGGAGTTTG ACACCCCATC GGTCCTTCTG TCCAACGACA 4380

GTTCCCGATT CTATGCCATG TTTGCTGCTG CAGAGAACAA GGTCGCTGTC AAGGGCTGAC 4440

TCCTCCCTGT TGACGAAGTC TCTTTTCTTT AGAGCATTGC CATTCCCTGC CTGGGGCGGG 4500 CCCCTCATCG CGTCCTCCTA CCGAAACCTT GCCTTTCTCG ATTTTATCTT TCGCACAGCA 4560

GTTCCGGATT GGCTTGTGTG TTTCACTTTT AGGGAGAGTC ATATTTTGAT TATTGTATTT 4620

ATTCCATATT CATGTAAACA AAATTTAGTT TTTGTTCTTA ATTGCACTCT AAAAGGTTCA 4680

GGGAACCGTT ATTATAATTG TATCAGAGGC CTATAATGAA GCTTTATACG TGTAGCTATA 4740

TCTATATATA ATTCTGTACA TAGCCTATAT TTACAGTGAA AATGTAAGCT GTTTATTTTA 4800 TATTAAAATA AGCACTGTGC TAATAACAGT GCATATTCCT TTCTATCATT TTTGTACAGT 4860

TTGCTGTACT AGAGATCTGG TTTTGCTATT AGACTGTAGG AAGAGTAGCA TTTCATTCTT 4920

CTCTAGCTGG TGGTTTCACG GTGCCAGGTT TTCTGGGTGT CCAAAGGAAG ACGTGTGGCA 4980

ATAGTGGGCC CTCCGACAGC CCCCTCTGCC GCCTCCCCAC AGCCGCTCCA GGGGTGGCTG 5040

GAGACGGGTG GGCGGCTGGA GACCATGCAG AGCGCCGTGA GTTCTCAGGG CTCCTGCCTT 5100 CTGTCCTGGT GTCACTTACT GTTTCTGTCA GGAGAGCAGC GGGGCGAAGC CCAGGCCCCT 5160

TTTCACTCCC TCCATCAAGA ATGGGGATCA CAGAGACATT CCTCCGAGCC GGGGAGTTTC 5220

TTTCCTGCCT TCTTCTTTTT GCTGTTGTTT CTAAACAAGA ATCAGTCTAT CCACAGAGAG 5280

TCCCACTGCC TCAGGTTCCT ATGGCTGGCC ACTGCACAGA GCTCTCCAGC TCCAAGACCT 5340

GTTGGTTCCA AGCCCTGGAG CCAACTGCTG CTTTTTGAGG TGGCACTTTT TCATTTGCCT 5400 ATTCCCACAC CTCCACAGTT CAGTGGCAGβ GCTCAGGATT TCGTGGGTCT GTTTTCCTTT 5460

CTCACCGCAG TCGTCGCACA GTCTCTCTCT CTCTCTCCCC TCAAAGTCTG CAACTTTAAG 5520

CAGCTCTTGC TAATCAGTGT CTCACACTGG CGTAGAAGTT TTTGTACTGT AAAGAGACCT 5580

ACCTCAGGTT GCTGGTTGCT GTGTGGTTTG GTGTGTTCCC GCAAACCCCC TTTGTGCTGT 5640

GGGGCTGGTA GCTCAGGTGG GCGTGGTCAC TGCTGTCATC AGTTGAATGG TCAGCGTTGC 5700 ATGTCGTGAC CAACTAGACA TTCTGTCGCC TTAGCATGTT TGCTGAACAC CTTGTGGAAG 5760

CAAAAATCTG AAAATGTGAA TAAAATTATT TTGGATTTTG TAAAAAAAAA AAAAAAAAAA 5820

AAAAAAAAAA AAAAAAAA

Seq ID NO: 585 Protein sequence Protein Accession ft: NP_005679.1

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MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL ETAARAEGLS 60

LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP VDNAGLFSCM TFSWLSSLAR 120

VAHKKGELSM EDVWSLSKHE SSDVNCRRLE RLWQEELNEV GPDAASLRRV VWIFCRTRLI 180

LSIVCLMITQ LAGFSGPAFM VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW 240

ALNYRTGVRL RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 300

PWAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA TDERVQKMNE 360 VLTYIKFIKM YAWVKAFSQS VQKIREEERR ILEKAGYFQG ITVGVAPIW VIASWTFSV 420

HMTLGFDLTA AQAFTWTVF NSMTFALKVT PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK 480

NKPASPHIKI EMKNATLAWD SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA 540

VLAEQKGHLL LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG 600

KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD EERYNSVLNS 660 CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY SDRSIYILDD PLSALDAHVG 720

NHIFNSAIRK HLKSKTVLFV THQLQYLVDC DEVIFMKEGC ITERGTHEEL MNLNGDYATI 780

FNNLLLGETP PVEINSKKET SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS 840 VPWSVYGVYI QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS 900

VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGWFVKGT LRASSRLHDE LFRRILRSPM g60

KFFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV FFCVGMIAGV FPWFLVAVGP 1020

LVILFSVLHI VSRVLIRELK RLDNITQSPF LSHITSSIQG LATIHAYNKG QEFLHRYQEL 1080

LDDNQAPFFL FTCAMRWLAV RLDLISIALI TTTGLMIVLM HGQIPPAYAG LAISYAVQLT 1140

GLFQFTVRLA SETEARFTSV ERINHYIKTL SLEAPARIKN KAPSPDWPQE GEVTFENAEM 1200

RYRENLPLVL KKVSFTIKPK EKIGIVGRTG SGKSSLGMAL FRLVELSGGC IKIDGVRISD 1260

IGLADLRSKL SIIPQEPVLF SGTVRSNLDP FNQYTEDQIW DALERTHMKE CIAQLPLKLE 1320

SEVMENGDNF SVGERQLLCI ARALLRHCKI LILDEATAAM DTETDLLIQE TIREAFADCT 1380 MLTIAHRLHT VLGSDRIMVL AQGQWEFDT PSVLLSNDSS RFYAMFAAAE NKVAVKG

Seq ID NO: 586 DNA sequence

Nucleic Acid Accession ft: NM_001327.1

Coding sequence: 89..631

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AGCAGGGGGC GCTGTGTGTA CCGAGAATAC GAGAATACCT CGTGGGCCCT GACCTTCTCT 60

CTGAGAGCCG GGCAGAGGCT CCGGAGCCAT GCAGGCCGAA GGCCGGGGCA CAGGGGGTTC 120

GACGGGCGAT GCTGATGGCC CAGGAGGCCC TGGCATTCCT GATGGCCCAG GGGGCAATGC 180

TGGCGGCCCA GGAGAGGCGG GTGCCACGGG CGGCAGAGGT CCCCGGGGCG CAGGGGCAGC 240

AAGGGCCTCG GGGCCGGGAG GAGGCGCCCC GCGGGGTCCG CATGGCGGCG CGGCTTCAGG 300

GCTGAATGGA TGCTGCAGAT GCGGGGCCAG GGGGCCGGAG AGCCGCCTGC TTGAGTTCTA 360

CCTCGCCATG CCTTTCGCGA CACCCATGGA AGCAGAGCTG GCCCGCAGGA GCCTGGCCCA 420

GGATGCCCCA CCGCTTCCCG TGCCAGGGGT GCTTCTGAAG GAGTTCACTG TGTCCGGCAA 480

CATACTGACT ATCCGACTGA CTGCTGCAGA CCACCGCCAA CTGCAGCTCT CCATCAGCTC 540

CTGTCTCCAG CAGCTTTCCC TGTTGATGTG GATCACGCAG TGCTTTCTGC CCGTGTTTTT 600

GGCTCAGCCT CCCTCAGGGC AGAGGCGCTA AGCCCAGCCT GGCGCCCCTT CCTAGGTCAT 660

GCCTCCTCCC CTAGGGAATG GTCCCAGCAC GAGTGGCCAG TTCATTGTGG GGGCCTGATT 720 GTTTGTCGCT GGAGGAGGAC GGCTTACATG TTTGTTTCTG TAGAAAATAA AACTGAGCTA

Seq ID NO: 587 Protein sequence Protein Accession ft: NP_001318.1

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I I I I I 1

MQAEGRGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPGGGA 60 PRGPHGGAAS GLNGCCRCGA RGPESRLLEF YLAMPFATPM EAELARRSLA QDAPPLPVPG 120 VLLKEFTVSG NILTIRLTAA DHRQLQLSIS SCLQQLSLLM WITQCFLPVF LAQPPSGQRR

Seq ID NO: 588 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 52..459

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I I I I I I

CCTCGTGGGC CCTGACCTTC TCTCTGAGAG CCGGGCAGAG GCTCCGGAGC CATGCAGGCC 60

GAAGGCCAGG GCACAGGGGG TTCGACGGGC GATGCTGATG GCCCAGGAGG CCCTGGCATT 120

CCTGATGGCC CAGGGGGCAA TGCTGGCGGC CCAGGAGAGG CGGGTGCCAC GGGCGGCAGA 180 GGTCCCCGGG GCGCAGGGGC AGCAAGGGCC TCGGGGCCGA GAGGAGGCGC CCCGCGGGGT 240

CCGCATGGCG GTGCCGCTTC TGCGCAGGAT GGAAGGTGCC CCTGCGGGGC CAGGAGGCCG 300

GACAGCCGCC TGCTTCAGTT CCGACTGACT GCTGCAGACC ACCGCCAACT GCAGCTCTCC 360

ATCAGCTCCT GTCTCCAGCA GCTTTCCCTG TTGATGTGGA TCACGCAGTG CTTTCTGCCC 420

GTGTTTTTGG CTCAGGCTCC CTCAGGGCAG AGGCGCTAAG CCCAGCCTGG CGCCCCTTCC 480 TAGGTCATGC CTCCTCCCCT AGGGAATGGT CCCAGCACGA GTGGCCAGTT CATTGTGGGG 540

GCCTGATTGT TTGTCGCTGG AGGAGGACGG CTTACATGTT TGTTTCTGTA GAAAATAAAG 600 CTGAGCTA

Seq ID NO: 589 Protein sequence Protein Accession ft: Eos sequence

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1 I I I I I

MQAEGQGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPRGGA 60 PRGPHGGAAS AQDGRCPCGA RRPDSRLLQF RLTAADHRQL QLSISSCLQQ LSLLMWITQC 120 FLPVFLAQAP SGQRR

Seq ID NO: 590 DNA sequence Nucleic Acid Accession ft: NM_005562.1 Coding sequence: 90..3671

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I 1 I I I I

ACAGCGGAGC GCAGAGTGAG AACCACCAAC CGAGGCGCCG GGCAGCGACC CCTGCAGCGG 60

AGACAGAGAC TGAGCGGCCC GGCACCGCCA TGCCTGCGCT CTGGCTGGGC TGCTGCCTCT 120

GCTTCTCGCT CCTCCTGCCC GCAGCCCGGG CCACCTCCAG GAGGGAAGTC TGTGATTGCA 180

ATGGGAAGTC CAGGCAGTGT ATCTTTGATC GGGAACTTCA CAGACAAACT GGTAATGGAT 240

TCCGCTGCCT CAACTGCAAT GACAACACTG ATGGCATTCA CTGCGAGAAG TGCAAGAATG 300

GCTTTTACCG GCACAGAGAA AGGGACCGCT GTTTGCCCTG CAATTGTAAC TCCAAAGGTT 360 CTCTTAGTGC TCGATGTGAC AACTCTGGAC GGTGCAGCTG TAAACCAGGT GTGACAGGAG 420

CCAGATGCGA CCGATGTCTG CCAGGCTTCC ACATGCTCAC GGATGCGGGG TGCACCCAAG 480

ACCAGAGACT GCTAGACTCC AAGTGTGACT GTGACCCAGC TGGCATCGCA GGGCCCTGTG 540

ACGCGGGCCG CTGTGTCTGC AAGCCAGCTG TTACTGGAGA ACGCTGTGAT AGGTGTCGAT 600

CAGGTTACTA TAATCTGGAT GGGGGGAACC CTGAGGGCTG TACCCAGTGT TTCTGCTATG 660

GGCATTCAGC CAGCTGCCGC AGCTCTGCAG AATACAGTGT CCATAAGATC ACCTCTACCT 720

TTCATCAAGA TGTTGATGGC TGGAAGGCTG TCCAACGAAA TGGGTCTCCT GCAAAGCTCC 780

AATGGTCACA GCGCCATCAA GATGTGTTTA GCTCAGCCCA ACGACTAGAC CCTGTCTATT 840 TTGTGGCTCC TGCCAAATTT CTTGGGAATC AACAGGTGAG CTATGGGCAA AGCCTGTCCT 900 TTGACTACCG TGTGGACAGA GGAGGCAGAC ACCCATCTGC CCATGATGTG ATTCTGGAAG 960 GTGCTGGTCT ACGGATCACA GCTCCCTTGA TGCCACTTGG CAAGACACTG CCTTGTGGGC 1020 TCACCAAGAC TTACACATTC AGGTTAAATG AGCATCCAAG CAATAATTGG AGCCCCCAGC 1080 TGAGTTACTT TGAGTATCGA AGGTTACTGC GGAATCTCAC AGCCCTCCGC ATCCGAGCTA 1140 CATATGGAGA ATACAGTACT GGGTACATTG ACAATGTGAC CCTGATTTCA GCCCGCCCTG 1200 TCTCTGGAGC CCCAGCACCC TGGGTTGAAC AGTGTATATG TCCTGTTGGG TACAAGGGGC 1260 'AATTCTGCCA GGATTGTGCT TCTGGCTACA AGAGAGATTC AGCGAGACTG GGGCCTTTTG 1320 GCACCTGTAT TCCTTGTAAC TGTCAAGGGG GAGGGGCCTG TGATCCAGAC ACAGGAGATT 1380 GTTATTCAGG GGATGAGAAT CCTGACATTG AGTGTGCTGA CTGCCCAATT GGTTTCTACA 1440 ACGATCCGCA CGACCCCCGC AGCTGCAAGC CATGTCCCTG TCATAACGGG TTCAGCTGCT 1500 CAGTGATGCC GGAGACGGAG GAGGTGGTGT GCAATAACTG CCCTCCCGGG GTCACCGGTG 1560 CCCGCTGTGA GCTCTGTGCT GATGGCTACT TTGGGGACCC CTTTGGTGAA CATGGCCCAG 1620 TGAGGCCTTG TCAGCCCTGT CAATGCAACA ACAATGTGGA CCCCAGTGCC TCTGGGAATT 1680 GTGACCGGCT GACAGGCAGG TGTTTGAAGT GTATCCACAA CACAGCCGGC ATCTACTGCG 1740 ACCAGTGCAA AGCAGGCTAC TTCGGGGACC CATTGGCTCC CAACCCAGCA GACAAGTGTC 1800 GAGCTTGCAA CTGTAACCCC ATGGGCTCAG AGCCTGTAGG ATGTCGAAGT GATGGCACCT 1860 GTGTTTGCAA GCCAGGATTT GGTGGCCCCA ACTGTGAGCA TGGAGCATTC AGCTGTCCAG 1920 CTTGCTATAA TCAAGTGAAG ATTCAGATGG ATCAGTTTAT GCAGCAGCTT CAGAGAATGG 1980 AGGCCCTGAT TTCAAAGGCT CAGGGTGGTG ATGGAGTAGT ACCTGATACA GAGCTGGAAG 2040 GCAGGATGCA GCAGGCTGAG CAGGCCCTTC AGGACATTCT GAGAGATGCC CAGATTTCAG 2100 AAGGTGCTAG CAGATCCCTT GGTCTCCAGT TGGCCAAGGT GAGGAGCCAA GAGAACAGCT 2160 ACCAGAGCCG CCTGGATGAC CTCAAGATGA CTGTGGAAAG AGTTCGGGCT CTGGGAAGTC 2220 AGTACCAGAA CCGAGTTCGG GATACTCACA GGCTCATCAC TCAGATGCAG CTGAGCCTGG 2280 CAGAAAGTGA AGCTTCCTTG GGAAACACTA ACATTCCTGC CTCAGACCAC TACGTGGGGC 2340 CAAATGGCTT TAAAAGTCTG GCTCAGGAGG CCACAAGATT AGCAGAAAGC CACGTTGAGT 2400 CAGCCAGTAA CATGGAGCAA CTGACAAGGG AAACTGAGGA CTATTCCAAA CAAGCCCTCT 2460 CACTGGTGCG CAAGGCCCTG CATGAAGGAG TCGGAAGCGG AAGCGGTAGC CCGGACGGTG 2520 CTGTGGTGCA AGGGCTTGTG GAAAAATTGG AGAAAACCAA GTCCCTGGCC CAGCAGTTGA 2580 CAAGGGAGGC CACTCAAGCG GAAATTGAAG CAGATAGGTC TTATCAGCAC AGTCTCCGCC 2640 TCCTGGATTC AGTGTCTCGG CTTCAGGGAG TCAGTGATCA GTCCTTTCAG GTGGAAGAAG 2700 CAAAGAGGAT CAAACAAAAA GCGGATTCAC TCTCAACGCT GGTAACCAGG CATATGGATG 2760 AGTTCAAGCG TACACAAAAG AATCTGGGAA ACTGGAAAGA AGAAGCACAG CAGCTCTTAC 2820 AGAATGGAAA AAGTGGGAGA GAGAAATCAG ATCAGCTGCT TTCCCGTGCC AATCTTGCTA 2880 AAAGCAGAGC ACAAGAAGCA CTGAGTATGG GCAATGCCAC TTTTTATGAA GTTGAGAGCA 2940 TCCTTAAAAA CCTCAGAGAG TTTGACCTGC AGGTGGACAA CAGAAAAGCA GAAGCTGAAG 3000 AAGCCATGAA GAGACTCTCC TACATCAGCC AGAAGGTTTC AGATGCCAGT GACAAGACCC 3060 AGCAAGCAGA AAGAGCCCTG GGGAGCGCTG CTGCTGATGC ACAGAGGGCA AAGAATGGGG 3120 CCGGGGAGGC CCTGGAAATC TCCAGTGAGA TTGAACAGGA GATTGGGAGT CTGAACTTGG 3180 AAGCCAATGT GACAGCAGAT GGAGCCTTGG CCATGGAAAA GGGACTGGCC TCTCTGAAGA 3240 GTGAGATGAG GGAAGTGGAA GGAGAGCTGG AAAGGAAGGA GCTGGAGTTT GACACGAATA 3300 TGGATGCAGT ACAGATGGTG ATTACAGAAG CCCAGAAGGT TGATACCAGA GCCAAGAACG 3360 CTGGGGTTAC AATCCAAGAC ACACTCAACA CATTAGACGG CCTCCTGCAT CTGATGGACC 3420 AGCCTCTCAG TGTAGATGAA GAGGGGCTGG TCTTACTGGA GCAGAAGCTT TCCCGAGCCA 3480 AGACCCAGAT CAACAGCCAA CTGCGGCCCA TGATGTCAGA GCTGGAAGAG AGGGCACGTC 3540 AGCAGAGGGG CCACCTCCAT TTGCTGGAGA CAAGCATAGA TGGGATTCTG GCTGATGTGA 3600 AGAACTTGGA GAACATTAGG GACAACCTGC CCCCAGGCTG CTACAATACC CAGGCTCTTG 3660 AGCAACAGTG AAGCTGCCAT AAATATTTCT CAACTGAGGT TCTTGGGATA CAGATCTCAG 3720 GGCTCGGGAG CCATGTCATG TGAGTGGGTG GGATGGGGAC ATTTGAACAT GTTTAATGGG 3780 TATGCTCAGG TCAACTGACC TGACCCCATT CCTGATCCCA TGGCCAGGTG GTTGTCTTAT 3840 TGCACCATAC TCCTTGCTTC CTGATGCTGG GCAATGAGGC AGATAGCACT GGGTGTGAGA 3900 ATGATCAAGG ATCTGGACCC CAAAGAATAG ACTGGATGGA AAGACAAACT GCACAGGCAG 3960 ATGTTTGCCT CATAATAGTC GTAAGTGGAG TCCTGGAATT TGGACAAGTG CTGTTGGGAT 4020 ATAGTCAACT TATTCTTTGA GTAATGTGAC TAAAGGAAAA AACTTTGACT TTGCCCAGGC 4080 ATGAAATTCT TCCTAATGTC AGAACAGAGT GCAACCCAGT CACACTGTGG CCAGTAAAAT 4140 ACTATTGCCT CATATTGTCC TCTGCAAGCT TCTTGCTGAT CAGAGTTCCT CCTACTTACA 4200 ACCCAGGGTG TGAACATGTT CTCCATTTTC AAGCTGGAAG AAGTGAGCAG TGTTGGAGTG 4260 AGGACCTGTA AGGCAGGCCC ATTCAGAGCT ATGCTGCTTG CTGGTGCCTG CCACCTTCAA 4320 GTTCTGGACC TGGGCATGAC ATCCTTTCTT TTAATGATGC CATGGCAACT TAGAGATTGC 4380 ATTTTTATTA AAGCATTTCC TACCAGCAAA GCAAATGTTG GGAAAGTATT TACTTTTTCG 4440 GTTTCAAAGT GATAGAAAAG TGTGGCTTGG GCATTGAAAG AGGTAAAATT CTCTAGATTT 4500 ATTAGTCCTA ATTCAATCCT ACTTTTCGAA CACCAAAAAT GATGCGCATC AATGTATTTT 4560 ATCTTATTTT CTCAATCTCC TCTCTCTTTC CTCCACCCAT AATAAGAGAA TGTTCCTACT 4620 CACACTTCAG CTGGGTCACA TCCATCCCTC CATTCATCCT TCCATCCATC TTTCCATCCA 4680 TTACCTCCAT CCATCCTTCC AACATATATT TATTGAGTAC CTACTGTGTG CCAGGGGCTG 4740 GTGGGACAGT GGTGACATAG TCTCTGCCCT CATAGAGTTG ATTGTCTAGT GAGGAAGACA 4800 AGCATTTTTA AAAAATAAAT TTAAACTTAC AAACTTTGTT TGTCACAAGT GGTGTTTATT 4860 GCAATAACCG CTTGGTTTGC AACCTCTTTG CTCAACAGAA CATATGTTGC AAGACCCTCC 4920 CATGGGGGCA CTTGAGTTTT GGCAAGGCTG ACAGAGCTCT GGGTTGTGCA CATTTCTTTG 4980 CATTCCAGCT GTCACTCTGT GCCTTTCTAC AACTGATTGC AACAGACTGT TGAGTTATGA 5040 TAACACCAGT GGGAATTGCT GGAGGAACCA GAGGCACTTC CACCTTGGCT GGGAAGACTA 5100 TGGTGCTGCC TTGCTTCTGT ATTTCCTTGG ATTTTCCTGA AAGTGTTTTT AAATAAAGAA 5160 CAATTGTTAG ATGCC

Seq ID NO: 591 Protein sequence Protein Accession ft: NP 005553.1

11 21 31 41 51

I I I I I

MPALWLGCCL CFSLLLPAAR ATSRREVCDC N 1GKSRQCIFD RELHRQTGNG FRCLNCNDNT 60 DGIHCEKCKN GFYRHRERDR CLPCNCNSKG SLSARCDNSG RCSCKPGVTG ARCDRCLPGF 120 HMLTDAGCTQ DQRLLDSKCD CDPAGIAGPC DAGRCVCKPA VTGERCDRCR SGYYNLDGGN 180 PEGCTQCFCY GHSASCRSSA EYSVHKITST FHQDVDGWKA VQRNGSPAKL QWSQRHQDVF 240 SSAQRLDPVY FVAPAKFLGN QQVSYGQSLS FDYRVDRGGR HPSAHDVILE GAGLRITAPL 300 MPLGKTLPCG LTKTYTFRLN EHPSNNWSPQ LSYFEYRRLL RNLTALRIRA TYGEYSTGYI 360 DNVTLISARP VSGAPAPWVE QCICPVGYKG QFCQDCASGY KRDSARLGPF GTCIPCNCQG 420 GGACDPDTGD CYSGDENPDI ECADCPIGFY NDPHDPRSCK PCPCHNGFSC SVMPETEEW 480 CNNCPPGVTG ARCELCADGY FGDPFGEHGP VRPCQPCQCN NNVDPSASGN CDRLTGRCLK 540

CIHNTAGIYC DQCKAGYFGD PLAPNPADKC RACNCNPMGS EPVGCRSDGT CVCKPGFGGP 600

NCEHGAFSCP ACYNQVKIQM DQFMQQLQRM EALISKAQGG DG PDTELE GRMQQAEQAL 660

QDILRDAQIS EGASRSLGLQ LAKVRSQENS YQSRLDDLKM TVERVRALGS QYQNRVRDTH 720

RLITQMQLSL AESEASLGNT NIPASDHYVG PNGFKSLAQE ATRLAESHVE SASNMEQLTR 780

ETEDYSKQAL SLVRKALHEG VGSGΞGSPDG A QGLVEKL EKTKSLAQQL TREATQAEIE 840

ADRSYQHSLR LLDSVSRLQG VSDQSFQVEE AKRIKQKADS LSTLVTRHMD EFKRTQKNLG 900

NWKEEAQQLL QNGKSGREKS DQLLSRANLA KSRAQEALSM GNATFYEVES I KNLREFDL 60

QVDNRKAEAE EAMKRLSYIS QKVSDASDKT QQAERALGSA AADAQRAKNG AGEALEISSE 1020

IEQEIGSLNL EANVTADGAL AMEKGLASLK SEMREVEGEL ERKELEFDTN MDAVQMVITE 1080

AQKVDTRAKN AGVTIQDTLN TLDGLLHLMD QPLSVDEEGL VLLEQKLSRA KTQINSQLRP 1140 MMSELEERAR QQRGHLHLLE TSIDGILADV KNLENIRDNL PPGCYNTQAL EQQ

Seq ID NO: 592 DNA sequence Nucleic Acid Accession ft: AF101051.1

Coding sequence: 221.856

1 11 21 31 41 51

I I I 1 I I

GAGCAACCTC AGCTTCTAGT ATCCAGACTC CAGCGCCGCC CCGGGCGCGG ACCCCAACCC 60

CGACCCAGAG CTTCTCCAGC GGCGGCGCAG CGAGCAGGGC TCCCCGCCTT AACTTCCTCC 120

GCGGGGCCCA GCCACCTTCG GGAGTCCGGG TTGCCCACCT GCAAACTCTC CGCCTTCTGC 180

ACCTGCCACC CCTGAGCCAG CGCGGGCGCC CGAGCGAGTC ATGGCCAACG CGGGGCTGCA 240

GCTGTTGGGC TTCATTCTCG CCTTCCTGGG ATGGATCGGC GCCATCGTCA GCACTGCCCT 300

GCCCCAGTGG AGGATTTACT CCTATGCCGG CGACAACATC GTGACCGCCC AGGCCATGTA 360

CGAGGGGCTG TGGATGTCCT GCGTGTCGCA GAGCAGCGGG CAGATCCAGT GCAAAGTCTT 420

TGACTCCTTG CTGAATCTGA GCAGCACATT GCAAGCAACC CGTGCCTTGA TGGTGGTTGG 480

CATCCTCCTG GGAGTGATAG CAATCTTTGT GGCCACCGTT GGCATGAAGT GTATGAAGTG 540

CTTGGAAGAC GATGAGGTGC AGAAGATGAG GATGGCTGTC ATTGGGGGTG CGATATTTCT 600

TCTTGCAGGT CTGGCTATTT TAGTTGCCAC AGCATGGTAT GGCAATAGAA TCGTTCAAGA 660

ATTCTATGAC CCTATGACCC CAGTCAATGC CAGGTACGAA TTTGGTCAGG CTCTCTTCAC 720

TGGCTGGGCT GCTGCTTCTC TCTGCCTTCT GGGAGGTGCC CTACTTTGCT GTTCCTGTCC 780

CCGAAAAACA ACCTCTTACC CAACACCAAG GCCCTATCCA AAACCTGCAC CTTCCAGCGG 840

GAAAGACTAC GTGTGACACA GAGGCAAAAG GAGAAAATCA TGTTGAAACA AACCGAAAAT 900

GGACATTGAG ATACTATCAT TAACATTAGG ACCTTAGAAT TTTGGGTATT GTAATCTGAA 960

GTATGGTATT ACAAAACAAA CAAACAAACA AAAAACCCAT GTGTTAAAAT ACTCAGTGCT 1020

AAACATGGCT TAATCTTATT TTATCTTCTT TCCTCAATAT AGGAGGGAAG ATTTTACCAT 1080

TTGTATTACT GCTTCCCATT GAGTAATCAT ACTCAAATGG GGGAAGGGGT GCTCCTTAAA 1140

TATATATAGA TATGTATATA TACATGTTTT TCTATTAAAA ATAGACAGTA AAATACTATT 1200

CTCATTATGT TGATACTAGC ATACTTAAAA TATCTCTAAA ATAGGTAAAT GTATTTAATT 1260

CCATATTGAT GAAGATGTTT ATTGGTATAT TTTCTTTTTC GTCCTTATAT ACATATGTAA 1320

CAGTCAAATA TCATTTACTC TTCTTCATTA GCTTTGGGTG CCTTTGCCAC AAGACCTAGC 1380

CTAATTTACC AAGGATGAAT TCTTTCAATT CTTCATGCGT GCCCTTTTCA TATACTTATT 1440

TTATTTTTTA CCATAATCTT ATAGCACTTG CATCGTTATT AAGCCCTTAT TTGTTTTGTG 1500

TTTCATTGGT CTCTATCTCC TGAATCTAAC ACATTTCATA GCCTACATTT TAGTTTCTAA 1560

AGCCAAGAAG AATTTATTAC AAATCAGAAC TTTGGAGGCA AATCTTTCTG CATGACCAAA 1620

GTGATAAATT CCTGTTGACC TTCCCACACA ATCCCTGTAC TCTGACCCAT AGCACTCTTG 1680

TTTGCTTTGA AAATATTTGT CCAATTGAGT AGCTGCATGC TGTTCCCCCA GGTGTTGTAA 1740

CACAACTTTA TTGATTGAAT TTTTAAGCTA CTTATTCATA GTTTTATATC CCCCTAAACT 1800

ACCTTTTTGT TCCCCATTCC TTAATTGTAT TGTTTTCCCA AGTGTAATTA TCATGCGTTT 1860

TATATCTTCC TAATAAGGTG TGGTCTGTTT GTCTGAACAA AGTGCTAGAC TTTCTGGAGT 1920

GATAATCTGG TGACAAATAT TCTCTCTGTA GCTGTAAGCA AGTCACTTAA TCTTTCTACC 1980

TCTTTTTTCT ATCTGCCAAA TTGAGATAAT GATACTTAAC CAGTTAGAAG AGGTAGTGTG 2040

AATATTAATT AGTTTATATT ACTCTCATTC TTTGAACATG AACTATGCCT ATGTAGTGTC 2100

TTTATTTGCT CAGCTGGCTG AGACACTGAA GAAGTCACTG AACAAAACCT ACACACGTAC 2160

CTTCATGTGA TTCACTGCCT TCCTCTCTCT ACCAGTCTAT TTCCACTGAA CAAAACCTAC 2220

ACACATACCT TCATGTGGTT CAGTGCCTTC CTCTCTCTAC CAGTCTATTT CCACTGAACA 2280

AAACCTACGC ACATACCTTC ATGTGGCTCA GTGCCTTCCT CTCTCTACCA GTCTATTTCC 2340

ATTCTTTCAG CTGTGTCTGA CATGTTTGTG CTCTGTTCCA TTTTAACAAC TGCTCTTACT 2400

TTTCCAGTCT GTACAGAATG CTATTTCACT TGAGCAAGAT GATGTATGGA AAGGGTGTTG 2460

GCACTGGTGT CTGGAGACCT GGATTTGAGT CTTGGTGCTA TCAATCACCG TCTGTGTTTG 2520

AGCAAGGCAT TTGGCTGCTG TAAGCTTATT GCTTCATCTG TAAGCGGTGG TTTGTAATTC 2580

CTGATCTTCC CACCTCACAG TGATGTTGTG GGGATCCAGT GAGATAGAAT ACATGTAAGT 2640

GTGGTTTTGT AATTTGAAAA GTGCTATACT AAGGGAAAGA ATTGAGGAAT TAACTGCATA 2700

CGTTTTGGTG TTGCTTTTCA AATGTTTGAA AATAAAAAAA TGTTAAGAAA TGGGTTTCTT 2760

GCCTTAACCA GTCTCTCAAG TGATGAGACA GTGAAGTAAA ATTGAGTGCA CTAAACGAAT 2820

AAGATTCTGA GGAAGTCTTA TCTTCTGCAG TGAGTATGGC CCAATGCTTT CTGTGGCTAA 2880

ACAGATGTAA TGGGAAGAAA TAAAAGCCTA CGTGTTGGTA AATCCAACAG CAAGGGAGAT 2940

TTTTGAATCA TAATAACTCA TAAGGTGCTA TCTGTTCAGT GATGCCCTCA GAGCTCTTGC 3000

TGTTAGCTGG CAGCTGACGC TGCTAGGATA GTTAGTTTGG AAATGGTACT TCATAATAAA 3060

CTACACAAGG AAAGTCAGCC ACCGTGTCTT ATGAGGAATT- GGACCTAATA AATTTTAGTG 3120

TGCCTTCCAA ACCTGAGAAT ATATGCTTTT GGAAGTTAAA ATTTAAATGG CTTTTGCCAC 3180

ATACATAGAT CTTCATGATG TGTGAGTGTA ATTCCATGTG GATATCAGTT ACCAAACATT 3240

ACAAAAAAAT TTTATGGCCC AAAATGACCA ACGAAATTGT TACAATAGAA TTTATCCAAT 3300

TTTGATCTTT TTATATTCTT CTACCACACC TGGAAACAGA CCAATAGACA TTTTGGGGTT 3360

TTATAATGGG AATTTGTATA AAGCATTACT CTTTTTCAAT AAATTGTTTT TTAATTTAAA 3420 AAAAGGAAAA AAAAAAAAAA AAA

Seq ID NO: 593 Protein sequence Protein Accession ft: AAD16433.1

1 11 21 31 41 51

1 I I I I I

MANAGLQLLG FILAFLGWIG AIVSTALPQW RIYSYAGDNI VTAQAMYEGL WMSCVSQSTG 60

QIQCKVFDSL LNLSSTLQAT RALMWGILL GVIAIFVATV GMKCMKCLED DEVQKMRMAV 120

IGGAIFLLAG LAILVATAWY GNRIVQEFYD PMTPVNARYE FGQALFTGWA AASLCLLGGA 180 LLCCSCPRKT TSYPTPRPYP KPAP.SSGKDY V Seq ID NO: 594 DNA sequence

Nucleic Acid Accession ft: NM_006180.1

Coding sequence: 352..2820

1 11 21 31 41 51

I 1 I 1 I I

CCCCCATTCG CATCTAACAA GGAATCTGCG CCCCAGAGAG TCCCGGACGC CGCCGGTCGG 60

TGCCCGGCGC GCCGGGCCAT GCAGCGACGG CCGCCGCGGA GCTCCGAGCA GCGGTAGCGC 120

CCCCCTGTAA AGCGGTTCGC TATGCCGGGA CCACTGTGAA CCCTGCCGCC TGCCGGAACA 180

CTCTTCGCTC CGGACCAGCT CAGCCTCTGA TAAGCTGGAC TCGGCACGCC CGCAACAAGC 240

ACCGAGGAGT TAAGAGAGCC GCAAGCGCAG GGAAGGCCTC CCCGCACGGG TGGGGGAAAG 300

CGGCCGGTGC AGCGCGGGGA CAGGCACTCG GGCTGGCACT GGCTGCTAGG GATGTCGTCC 360

TGGATAAGGT GGCATGGACC CGCCATGGCG CGGCTCTGGG GCTTCTGCTG GCTGGTTGTG 420

GGCTTCTGGA GGGCCGCTTT CGCCTGTCCC ACGTCCTGCA AATGCAGTGC CTCTCGGATC 480

TGGTGCAGCG ACCCTTCTCC TGGCATCGTG GCATTTCCGA GATTGGAGCC TAACAGTGTA 540

GATCCTGAGA ACATCACCGA AATTTTCATC GCAAACCAGA AAAGGTTAGA AATCATCAAC 600

GAAGATGATG TTGAAGCTTA TGTGGGACTG AGAAATCTGA CAATTGTGGA TTCTGGATTA 660

AAATTTGTGG CTCATAAAGC ATTTCTGAAA AACAGCAACC TGCAGCACAT CAATTTTACC 720

CGAAACAAAC TGACGAGTTT GTCTAGGAAA CATTTCCGTC ACCTTGACTT GTCTGAACTG 780

ATCCTGGTGG GCAATCCATT TACATGCTCC TGTGACATTA TGTGGATCAA GACTCTCCAA 840

GAGGCTAAAT CCAGTCCAGA CACTCAGGAT TTGTACTGCC TGAATGAAAG CAGCAAGAAT 900

ATTCCCCTGG CAAACCTGCA GATACCCAAT TGTGGTTTGC CATCTGCAAA TCTGGCCGCA 960

CCTAACCTCA CTGTGGAGGA AGGAAAGTCT ATCACATTAT CCTGTAGTGT GGCAGGTGAT 1020

CCGGTTCCTA ATATGTATTG GGATGTTGGT AACCTGGTTT CCAAACATAT GAATGAAACA 1080

AGCCACACAC AGGGCTCCTT AAGGATAACT AACATTTCAT CCGATGACAG TGGGAAGCAG 1140

ATCTCTTGTG TGGCGGAAAA TCTTGTAGGA GAAGATCAAG ATTCTGTCAA CCTCACTGTG 1200

CATTTTGCAC CAACTATCAC ATTTCTCGAA TCTCCAACCT CAGACCACCA CTGGTGCATT 1260

CCATTCACTG TGAAAGGCAA CCCCAAACCA GCGCTTCAGT GGTTCTATAA CGGGGCAATA 1320

TTGAATGAGT CCAAATACAT CTGTACTAAA ATACATGTTA CCAATCACAC GGAGTACCAC 1380

GGCTGCCTCC AGCTGGATAA TCCCACTCAC ATGAACAATG GGGACTACAC TCTAATAGCC 1440

AAGAATGAGT ATGGGAAGGA TGAGAAACAG ATTTCTGCTC ACTTCATGGG CTGGCCTGGA 1500

ATTGACGATG GTGCAAACCC AAATTATCCT GATGTAATTT ATGAAGATTA TGGAACTGCA 1560

GCGAATGACA TCGGGGACAC CACGAACAGA AGTAATGAAA TCCCTTCCAC AGACGTCACT 1620

GATAAAACCG GTCGGGAACA TCTCTCGGTC TATGCTGTGG TGGTGATTGC GTCTGTGGTG 1680

GGATTTTGCC TTTTGGTAAT GCTGTTTCTG CTTAAGTTGG CAAGACACTC CAAGTTTGGC 1740

ATGAAAGGCC CAGCCTCCGT TATCAGCAAT GATGATGACT CTGCCAGCCC ACTCCATCAC 1800

ATCTCCAATG GGAGTAACAC TCCATCTTCT TCGGAAGGTG GCCCAGATGC TGTCATTATT 1860

GGAATGACCA AGATCCCTGT CATTGAAAAT CCCCAGTACT TTGGCATCAC CAACAGTCAG 1920

CTCAAGCCAG ACACATTTGT TCAGCACATC AAGCGACATA ACATTGTTCT GAAAAGGGAG 1980

CTAGGCGAAG GAGCCTTTGG AAAAGTGTTC CTAGCTGAAT GCTATAACCT CTGTCCTGAG 2040

CAGGACAAGA TCTTGGTGGC AGTGAAGACC CTGAAGGATG CCAGTGACAA TGCACGCAAG 2100

GACTTCCACC GTGAGGCCGA GCTCCTGACC AACCTCCAGC ATGAGCACAT CGTCAAGTTC 2160

TATGGCGTCT GCGTGGAGGG CGACCCCCTC ATCATGGTCT TTGAGTACAT GAAGCATGGG 2220

GACCTCAACA AGTTCCTCAG GGCACACGGC CCTGATGCCG TGCTGATGGC TGAGGGCAAC 2280

CCGCCCACGG AACTGACGCA GTCGCAGATG CTGCATATAG CCCAGCAGAT CGCCGCGGGC 2340

ATGGTCTACC TGGCGTCCCA GCACTTCGTG CACCGCGATT TGGCCACCAG GAACTGCCTG 2400

GTCGGGGAGA ACTTGCTGGT GAAAATCGGG GACTTTGGGA TGTCCCGGGA CGTGTACAGC 2460

ACTGACTACT ACAGGGTCGG TGGCCACACA ATGCTGCCCA TTCGCTGGAT GCCTCCAGAG 2520

AGCATCATGT ACAGGAAATT CACGACGGAA AGCGACGTCT GGAGCCTGGG GGTCGTGTTG 2580

TGGGAGATTT TCACCTATGG CAAACAGCCC TGGTAGCAGC TGTCAAACAA TGAGGTGATA 2640

GAGTGTATCA CTCAGGGCCG AGTCCTGCAG CGACCCCGCA CGTGCCCCCA GGAGGTGTAT 2700

GAGCTGATGC TGGGGTGCTG GCAGCGAGAG CCCCACATGA GGAAGAACAT CAAGGGCATC 2760

CATACCCTCC TTCAGAACTT GGCCAAGGCA TCTCCGGTCT ACCTGGACAT TCTAGGCTAG 2820

GGCCCTTTTC CCCAGACCGA TCCTTCCCAA CGTACTCCTC AGACGGGCTG AGAGGATGAA 2880

CATCTTTTAA CTGCCGCTGG AGGCCACCAA GCTGCTCTCC TTCACTCTGA CAGTATTAAC 2940

ATCAAAGACT CCGAGAAGCT CTCGAGGGAA GCAGTGTGTA CTTCTTCATC CATAGACACA 3000

GTATTGACTT CTTTTTGGCA TTATCTCTTT CTCTCTTTCC ATCTCCCTTG GTTGTTCCTT 3060

TTTCTTTTTT TAAATTTTCT TTTTCTTCTT TTTTTTCGTC TTCCCTGCTT CACGATTCTT 3120

ACCCTTTCTT TTGAATCAAT CTGGCTTCTG CATTACTATT AACTCTGCAT AGACAAAGGC 3180

CTTAACAAAC GTAATTTGTT ATATCAGCAG ACACTCCAGT TTGCCCACCA CAACTAACAA 3240

TGCGTTGTTG TATTCCTGCC TTTGATGTGG ATGAAAAAAA GGGAAAACAA ATATTTCACT 3300

TAAACTTTGT CACTTCTGCT GTACAGATAT CGAGAGTTTC TATGGATTCA CTTCTATTTA 3360

TTTATTATTA TTACTGTTCT TATTGTTTTT GGATGGCTTA AGCCTGTGTA TAAAAAAGAA 3420

AACTTGTGTT CAATCTGTGA AGCCTTTATC TATGGGAGAT TAAAACCAGA GAGAAAGAAG 3480

ATTTATTATG AACCGCAATA TGGGAGGAAC AAAGACAACC ACTGGGATCA GCTGGTGTCA 3540

GTCCCTACTT AGGAAATACT CAGCAACTGT TAGCTGGGAA GAATGTATTC GGCACCTTCC 3600

CCTGAGGACC TTTCTGAGGA GTAAAAAGAC TACTGGCCTC TGTGCCATGG ATGATTGTTT 3660 TCCCATCACC AGAAATGATA GCGTGCAGTA GAGAGCAAAG ATGGCTT

Seq ID NO: 595 Protein sequence Protein Accession ft: NP_006171.1

1 11 21 31 41 51

I I I I I I

MSSWIRWHGP AMARLWGFCW LWGFWRAAF ACPTSCKCSA SRIWCSDPSP GIVAFPRLEP 60

NSVDPENITE IFIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAHKA FLKNSNLQHI 120

NFTRNKLTSL SRKHFRHLDL SELILVGNPF TCSCDIMWIK TLQEAKSSPD TQDLYCLNES 180

SKNIPLANLQ IPNCGLPSAN LAAPNLTVEE GKSITLSCSV AGDPVPNMYW DVGNLVSKHM 240

NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 300

WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT 360

LIAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNRSNEIPST 420

DVTDKTGREH LSVYAVWIA SWGFCLLVM LFLLKLARHS KFGMKGPASV ISNDDDSASP 480

LHHISNGSNT PSSSEGGPDA VIIGMTKIPV IENPQYFGIT NSQLKPDTFV QHIKRHNIVL 540

KRELGEGAFG KVFLAECYNL CPEQDKILVA VKTLKDASDN ARKDFHREAE LLTNLQHEHI 600

VKFYGVCVEG DPLIMVFEYM KHGDLNKFLR AHGPDAVLMA EGNPPTELTQ SQMLHIAQQI 660

AAGMVYLASQ HFVHRDLATR NCLVGENLLV KIGDFGMSRD VYSTDYYRVG GHTMLPIRWM 720 PPESIMYRKF TTESDVWSLG LWEIFTYG KQPWYQLSNN EVIECITQGR VLQRPRTCPQ 780 EVYELMLGCW QREPHMRKNI KGIHTLLQNL AKASPVYLDI LG

Seq ID NO: 596 DNA sequence Nucleic Acid Accession ft: AF410899 Coding sequence: 483..2999

1 11 21 31 41 51

1 I I I ! I

GGGAGCAGGA GCCTCGCTGG CTGCTTCGCT CGCGCTCTAC GCGCTCAGTC CCCGGCGGTA 60

GCAGGAGCCT GGACCCAGGC GCCGGCGGCG GGCGTGAGGC GCCGGAGCCC GGCCTCGAGG 120

TGCATACCGG ACCCCCATTC GCATCTAACA AGGAATCTGC GCCCCAGAGA GTCCCGGACG 180

CCGCCGGTCG GTGCCCGGCG CGCCGGGCCA TGCAGCGACG GCCGCCGCGG AGCTCCGAGC 240

AGCGGTAGCG CCCCCCTGTA AAGCGGTTCG CTATGCCGGG ACCACTGTGA ACCCTGCCGC 300

CTGCCGGAAC ACTCTTCGCT CCGGACCAGC TCAGCCTCTG ATAAGCTGGA CTCGGCACGC 360

CCGCAACAAG CACCGAGGAG TTAAGAGAGC CGCAAGCGCA GGGAAGGCCT CCCCGCACGG 420

GTGGGGGAAA GCGGCCGGTG CAGCGCGGGG ACAGGCACTC GGGCTGGCAC TGGCTGCTAG 480

GGATGTCGTC CTGGATAAGG TGGCATGGAC CCGCCATGGC GCGGCTCTGG GGCTTCTGCT 540

GGCTGGTTGT GGGCTTCTGG AGGGCCGCTT TCGCCTGTCC CACGTCCTGC AAATGCAGTG 600

CCTCTCGGAT CTGGTGCAGC GACCCTTCTC CTGGCATCGT GGCATTTCCG AGATTGGAGC 660

CTAACAGTGT AGATCCTGAG AACATCACCG AAATTTTCAT CGCAAACCAG AAAAGGTTAG 720

AAATCATCAA CGAAGATGAT GTTGAAGCTT ATGTGGGACT GAGAAATCTG ACAATTGTGG 780

ATTCTGGATT AAAATTTGTG GCTCATAAAG CATTTCTGAA AAACAGCAAC CTGCAGCACA 840

TCAATTTTAC CCGAAACAAA CTGACGAGTT TGTCTAGGAA ACATTTCCGT CACCTTGACT 900

TGTCTGAACT GATCCTGGTG GGCAATCCAT- TTACATGCTC CTGTGACATT ATGTGGATCA 960

AGACTCTCCA AGAGGCTAAA TCCAGTCCAG ACACTCAGGA TTTGTACTGC CTGAATGAAA 1020

GCAGCAAGAA TATTCCCCTG GCAAACCTGC AGATACCCAA TTGTGGTTTG CCATCTGCAA 1080

ATCTGGCCGC ACCTAACCTC ACTGTGGAGG AAGGAAAGTC TATCACATTA TCCTGTAGTG 1140

TGGCAGGTGA TCCGGTTCCT AATATGTATT GGGATGTTGG TAACCTGGTT TCCAAACATA 1200

TGAATGAAAC AAGCCACACA CAGGGCTCCT TAAGGATAAC TAACATTTCA TCCGATGACA 1260

GTGGGAAGCA GATCTCTTGT GTGGCGGAAA ATCTTGTAGG AGAAGATCAA GATTCTGTCA 1320

ACCTCACTGT GCATTTTGCA CCAACTATCA CATTTCTCGA ATCTCCAACC TCAGACCACC 1380

ACTGGTGCAT TCCATTCACT GTGAAAGGCA ACCCCAAACC AGCGCTTCAG TGGTTCTATA 1440

ACGGGGCAAT ATTGAATGAG TCCAAATACA TCTGTACTAA AATACATGTT ACCAATCACA 1500

CGGAGTACCA CGGCTGCCTC CAGCTGGATA ATCCCACTCA CATGAACAAT GGGGACTACA 1560

CTCTAATAGC CAAGAATGAG TATGGGAAGG ATGAGAAACA GATTTCTGCT CACTTCATGG 1620

GCTGGCCTGG AATTGACGAT GGTGCAAACC CAAATTATCC TGATGTAATT TATGAAGATT 1680

ATGGAACTGC AGCGAATGAC ATCGGGGACA CCACGAACAG AAGTAATGAA ATCCCTTCCA 1740

CAGACGTCAC TGATAAAACC GGTCGGGAAC ATCTCTCGGT CTATGCTGTG GTGGTGATTG 1800

CGTCTGTGGT GGGATTTTGC CTTTTGGTAA TGCTGTTTCT GCTTAAGTTG GCAAGACACT 1860

CCAAGTTTGG CATGAAAGAT TTCTCATGGT TTGGATTTGG GAAAGTAAAA TCAAGACAAG 1920

GTGTTGGCCC AGCCTCCGTT ATCAGCAATG ATGATGACTC TGCCAGCCCA CTCCATCACA 1980

TCTCCAATGG GAGTAACACT CCATCTTCTT CGGAAGGTGG CCCAGATGCT GTCATTATTG 2040

GAATGACCAA GATCCCTGTC ATTGAAAATC CCCAGTACTT TGGCATCACC AACAGTCAGC 2100

TCAAGCCAGA CACATTTGTT CAGCACATCA AGCGACATAA CATTGTTCTG AAAAGGGAGC 2160

TAGGCGAAGG AGCCTTTGGA AAAGTGTTCC TAGCTGAATG CTATAACCTC TGTCCTGAGC 2220

AGGACAAGAT CTTGGTGGCA GTGAAGACCC TGAAGGATGC CAGTGACAAT GCACGCAAGG 2280

ACTTCCACCG TGAGGCCGAG CTCCTGACCA ACCTCCAGCA TGAGCACATC GTCAAGTTCT 2340

ATGGCGTCTG CGTGGAGGGC GACCCCCTCA TCATGGTCTT TGAGTACATG AAGCATGGGG 2400

ACCTCAACAA GTTCCTCAGG GCACACGGCC CTGATGCCGT GCTGATGGCT GAGGGCAACC 2460

CGCCCACGGA ACTGACGCAG TCGCAGATGC TGCATATAGC CCAGCAGATC GCCGCGGGCA 2520

TGGTCTACCT GGCGTCCCAG CACTTCGTGC ACCGCGATTT GGCCACCAGG AACTGCCTGG 2580

TCGGGGAGAA CTTGCTGGTG AAAATCGGGG ACTTTGGGAT GTCCCGGGAC GTGTACAGCA 2640

CTGACTACTA CAGGGTCGGT GGCCACACAA TGCTGCCCAT TCGCTGGATG CCTCCAGAGA 2700

GCATCATGTA CAGGAAATTC ACGACGGAAA GCGACGTCTG GAGCCTGGGG GTCGTGTTGT 2760

GGGAGATTTT CACCTATGGC AAACAGCCCT GGTACCAGCT GTCAAACAAT GAGGTGATAG 2820

AGTGTATCAC TCAGGGCCGA GTCCTGCAGC GACCCCGCAC GTGCCCCCAG GAGGTGTATG 2880

AGCTGATGCT GGGGTGCTGG CAGCGAGAGC CCCACATGAG GAAGAACATC AAGGGCATCC 2940

ATACCCTCCT TCAGAACTTG GCCAAGGCAT CTCCGGTCTA CCTGGACATT CTAGGCTAGG 3000

GCCCTTTTCC CCAGACCGAT CCTTCCCAAC GTACTCCTCA GACGGGCTGA GAGGATGAAC 3060

ATCTTTTAAC TGCCGCTGGA GGCCACCAAG CTGCTCTCCT TCACTCTGAC AGTATTAACA 3120

TCAAAGACTC CGAGAAGCTC TCGAGGGAAG CAGTGTGTAC TTCTTCATCC ATAGACACAG 3180

TATTGACTTC TTTTTGGCAT TATCTCTTTC TCTCTTTCCA TCTCCCTTGG TTGTTCCTTT 3240

TTCTTTTTTT AAATTTTCTT TTTCTTCTTT TTTTTCGTCT TCCCTGCTTC ACGATTCTTA 3300

CCCTTTCTTT TGAATCAATC TGGCTTCTGC ATTACTATTA ACTCTGCATA GACAAAGGCC 3360

TTAACAAACG TAATTTGTTA TATCAGCAGA CACTCCAGTT TGCCCACCAC AACTAACAAT 3420

GCCTTGTTGT ATTCCTGCCT TTGATGTGGA TGAAAAAAAG GGAAAACAAA TATTTCACTT 3480

AAACTTTGTC ACTTCTGCTG TACAGATATC GAGAGTTTCT ATGGATTCAC TTCTATTTAT 3540

TTATTATTAT TACTGTTCTT ATTGTTTTTG GATGGCTTAA GCCTGTGTAT AAAAAAGAAA 3600

ACTTGTGTTC AATCTGTGAA GCCTTTATCT ATGGGAGATT AAAACCAGAG AGAAAGAAGA 3660

TTTATTATGA ACCGCAATAT GGGAGGAACA AAGACAACCA CTGGGATCAG CTGGTGTCAG 3720

TCCCTACTTA GGAAATACTC AGCAACTGTT AGCTGGGAAG AATGTATTCG GCACCTTCCC 3780

CTGAGGACCT TTCTGAGGAG TAAAAAGACT ACTGGCCTCT GTGCCATGGA TGATTCTTTT 3840

CCCATCACCA GAAATGATAG CGTGCAGTAG AGAGCAAAGA TGGCTTCCGT GAGACACAAG 3900

ATGGCGCATA GTGTGCTCGG ACACAGTTTT GTCTTCGTAG GTTGTGATGA TAGCACTGGT 3960

TTGTTTCTCA AGCGCTATCC ACAGAACCTT TGTCAACTTC AGTTGAAAAG AGGTGGATTC 4020 ATGTCCAGAG CTCATTTCGG GGTCAGGTGG GAAAGCC

Seq ID NO: 597 Protein sequence Protein Accession ft: AAL67965.1

1 11 21 31 41 51

I 1 I I I 1

MSSWIRWHGP AMARLWGFCW LWGFWRAAF ACPTSCKCSA SRIWCSDPSP GIVAFPRLEP 60

NSVDPENITE IFIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAHKA FLKNSNLQHI 120

NFTRNKLTSL SRKHFRHLDL SELILVGNPF TCSCDIMWIK TLQEAKSSPD TQDLYCLNES 180

SKNIPLANLQ IPNCGLPSAN LAAPNLTVEE GKSITLSCSV AGDPVPNMYW DVGNLVSKHM 240 NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 300

WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT 360

LIAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNRSNEIPST 420

DVTDKTGREH LSVYAVWIA SWGFCLLVM LFLLKLARHS KFGMKDFSWF GFGKVKSRQG 480

VGPASVISND DDSASPLHHI SNGSNTPSSS EGGPDAVIIG MTKIPVIENP QYFGITNSQL 540

KPDTFVQHIK RHNIVLKREL GEGAFGKVFL AECYNLCPEQ DKILVAVKTL KDASDNARKD 600

FHREAELLTN LQHEHIVKFY GVCVEGDPLI MVFEYMKHGD LNKFLRAHGP DAVLMAEGNP 660

PTELTQSQML HIAQQIAAGM VYLASQHFVH RDLATRNCLV GENLLVKIGD FGMSRDVYST 720

DYYRVGGHTM LPIRWMPPES IMYRKFTTES DVWSLGWLW EIFTYGKQPW YQLSNNEVIE 780 CITQGRVLQR PRTCPQEVYE LMLGCWQREP HMRKNIKGIH TLLQNLAKAS PVYLDILG

Seq ID NO: 598 DNA sequence Nucleic Acid Accession ft: AB052906 Coding sequence: 74..814

1 11 21 31 41 51

I I 1 I 1 I

AAAACCTTGA GGTGATTCAT CTTCCAGGCT CTCCTTCCAT CAAGTCTCTC CTCCCTAGCG 60

CTCTGGGTCC TTAATGGCAG CAGCCGCCGC TACCAAGATC CTTCTGTGCC TCCCGCTTCT 120

GCTCCTGCTG TCCGGCTGGT CCCGGGCTGG GCGAGCCGAC CCTCACTCTC TTTGCTATGA 180

CATCACCGTC ATCCCTAAGT TCAGACCTGG ACCACGGTGG TGTGCGGTTC AAGGCCAGGT 240

GGATGAAAAG ACTTTTCTTC ACTATGACTG TGGCAACAAG ACAGTCACAC CTGTCAGTCC 300

CCTGGGGAAG AAACTAAATG TCACAACGGC CTGGAAAGCA CAGAACCCAG TACTGAGAGA 360

GGTGGTGGAC ATACTTACAG AGCAACTGCG TGACATTCAG CTGGAGAATT ACACACCCAA 420

GGAACCCCTC ACCCTGCAGG CCAGGATGTC TTGTGAGCAG AAAGCTGAAG GACACAGCAG 480

TGGATCTTGG CAGTTCAGTT TCGATGGGCA ^'GATCTTCCTC CTCTTTGACT CAGAGAAGAG 540

AATGTGGACA ACGGTTCATC CTGGAGCCAG AAAGATGAAA GAAAAGTGGG AGAATGACAA 600

GGTTGTGGCC ATGTCCTTCC ATTACTTCTC AATGGGAGAC TGTATAGGAT GGCTTGAGGA 660

CTTCTTGATG GGCATGGACA GCACCCTGGA GCCAAGTGCA GGAGCACCAC TCGCCATGTC 720

CTCAGGCACA ACCCAACTCA GGGCCACAGC CACCACCCTC ATCCTTTGCT GCCTCCTCAT 780

CATCCTCCCC TGCTTCATCC TCCCTGGCAT CTGAGGAGAG TCCTTTAGAG TGACAGGTTA 8 0

AAGCTGATAC CAAAAGGCTC CTGTGAGCAC GGTCTTGATC AAACTCGCCC TTCTGTCTGG 900

CCAGCTGCCC ACGACCTACG GTGTATGTCC AGTGGCCTCC AGCAGATCAT GATGACATCA 960

TGGACCCAAT AGCTCATTCA CTGCCTTGAT TCCTTTTGCC AACAATTTTA CCAGCAGTTA 1020

TACCTAACAT ATTATGCAAT TTTCTCTTGG TGCTACCTGA TGGAATTCCT GCACTTAAAG 1080

TTCTGGCTGA CTAAACAAGA TATATCATTT TCTTTCTTCT CTTTTTGTTT GGAAAATCAA 1140

GTACTTCTTT GAATGATGAT CTCTTTCTTG CAAATGATAT TGTCAGTAAA ATAATCACGT 1200

TAGACTTCAG ACCTCTGGGG ATTCTTTCCG TGTCCTGAAA GAGAATTTTT AAATTATTTA 1260

ATAAGAAAAA ATTTATATTA ATGATTGTTT CCTTTAGTAA TTTATTGTTC TGTACTGATA 1320 TTTAAATAAA GAGTTCTATT TCCCAAAAAA AAAAAAAAAA AA

Seq ID NO: 599 Protein sequence Protein Accession ft: BAB61048.1

1 11 21 31 41 51

1 I I I 1 1

MAAAAATKIL LCLPLLLLLS GWSRAGRADP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT 60

FLHYDCGNKT VTPVSPLGKK LNVTTAWKAQ NPVLRE DI LTEQLRDIQL ENYTPKEPLT 120

LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL FDSEKRMWTT VHPGARKMKE KWENDKWAM 180

SFHYFSMGDC IGWLEDFLMG MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC 240 FILPGI

Seq ID NO: 600 DNA sequence Nucleic Acid Accession ft: NM_ Coding sequence: 57..482

1 11 21 31 41 51

I I I I I I

GGCTCTCACC CTCCTCTCCT GCAGCTCCAG CTTTGTGCTC TGCCTCTGAG GAGACCATGG 60

CCCAGTATCT GAGTACCCTG CTGCTCCTGC TGGCCACCCT AGCTGTGGCC CTGGCCTGGA 120

GCCCCAAGGA GGAGGATAGG ATAATCCCGG GTGGCATCTA TAACGCAGAC CTCAATGATG 180

AGTGGGTACA GCGTGCCCTT CACTTCGCCA TCAGCGAGTA TAACAAGGCC ACCAAAGATG 240

ACTACTACAG ACGTCCGCTG CGGGTACTAA GAGCCAGGCA ACAGACCGTT GGGGGGGTGA 300

ATTACTTCTT CGACGTAGAG GTGGGCCGCA CCATATGTAC CAAGTCCCAG CCCAACTTGG 360

ACACCTGTGC CTTCCATGAA CAGCCAGAAC TGCAGAAGAA ACAGTTGTGC TCTTTCGAGA 420

TCTACGAAGT TCCCTGGGAG AACAGAAGGT CCCTGGTGAA ATCCAGGTGT CAAGAATCCT 480

AGGGATCTGT GCCAGGCCAT TCGCACCAGC CACCACCCAC TCCCACCCCC TGTAGTGCTC 540

CCACCCCTGG ACTGGTGGCC CCCACCCTGC GGGAGGCCTC CCCATGTGCC TGCGCCAAGA 600

GACAGACAGA GAAGGCTGCA GGAGTCCTTT GTTGCTCAGC AGGGCGCTCT GCCCTCCCTC 660

CTTCCTTCTT GCTTCTAATA GCCCTGGTAC ATGGTACACA CCCCCCCACC TCCTGCAATT 720 AAACAGTAGC ATCGCC

Seq ID NO: 601 Protein sequence Protein Accession ft: NP_001889.1

1 11 21 31 41 51

I I I I I I

MAQYLSTLLL LLATLAVALA WSPKEEDRII PGGIYNADLN DEWVQRALHF AISEYNKATK 60 DDYYRRPLRV LRARQQTVGG VNYFFDVEVG RTICTKSQPN LDTCAFHEQP ELQKKQLCSF 120 EIYEVPWENR RSLVKSRCQE S

Seq ID NO: 602 DNA sequence

Nucleic Acid Accession ft: NM_003976.2

Coding sequence: 299.961

1 11 21 31 41 51

I I I I I I CTCTGAGCTT CTCTGAGCCT TGTTTGCTCA TCTGGAAAAA GGGGATTAAA CCATTTACCT 60

CATGGAGTTG TGAAAGAATA GCTGCAAAGC ACCTAACACA TAGTAAGGTT CCCAGTGCAG 120

CTACTTCTGC TGGGTTGAGT CTAGCTGTGT AGGCCCCTTG TTCCTCACCT GGAGAAAGTG 180

GGGTGGCAGG CCGGTCCCCC ACAAAAGATA ACTCATCTCT TAATTTGCAA GCTGCCTCAA 240

CAGGAGGGTG GGGGAACAGC TCAACAATGG CTGATGGGCG CTCCTGGTGT TGATAGAGAT 300

GGAACTTGGA CTTGGAGGCC TCTCCACGCT GTCCCACTGC CCCTGGCCTA GGCGGCAGCC 360

TGCCCTGTGG CCCACCCTGG CCGCTCTGGC TCTGCTGAGC AGCGTCGCAG AGGCCTCCCT 420

GGGCTCCGCG CCCCGCAGCC CTGCCCCCCG CGAAGGCCCC CCGCCTGTCC TGGCGTCCCC 480

CGCCGGCCAC CTGCCGGGGG GACGCACGGC CCGCTGGTGC AGTGGAAGAG CCCGGCGGCC 540

10 GCCGCCGCAG CCTTCTCGGC CCGCGCCCCC GCCGCCTGCA CCCCCATCTG CTCTTCCCCG 600

CGGGGGCCGC GCGGCGCGGG CTGGGGGCCC GGGCAGCCGC GCTCGGGCAG CGGGGGCGCG 660

GGGCTGCCGC CTGCGCTCGC AGCTGGTGCC GGTGCGCGCG CTCGGCCTGG GCCACCGCTC 720

CGACGAGCTG GTGCGTTTCC GCTTCTGCAG CGGCTCCTGC CGCCGCGCGC GCTCTCCACA 780

CGACCTCAGC CTGGCCAGCC TACTGGGCGC CGGGGCCCTG CGACCGCCCC CGGGCTCCCG 840

15 GCCCGTCAGC CAGCCCTGCT GCCGACCCAC GCGCTACGAA GCGGTCTCCT TCATGGACGT 900

CAACAGCACC TGGAGAACCG TGGACCGCCT CTCCGCCACC GCCTGCGGCT GCCTGGGCTG 60

AGGGCTCGCT CCAGGGCTTT GCAGACTGGA CCCTTACCGG TGGCTCTTCC TGCCTGGGAC 1020

CCTCCCGCAG AGTCCCACTA GCCAGCGGCC TCAGCCAGGG ACGAAGGCCT CAAAGCTGAG 1080

AGGCCCCTAC CGGTGGGTGA TGGATATCAT CCCCGAACAG GTGAAGGGAC AACTGACTAG 1140

20 CAGCCCCAGA GCCCTCACCC TGCGGATCCC AGCCTAAAAG ACACCAGAGA CCTCAGCTAT 1200

GGAGCCCTTC GGACCCACTT CTCACAGACT CTGGCACTGG CCAGGCCTCG AACCTGGGAC 1260

CCCTCCTCTG ATGAACACTA CAGTGGCTGA GGCATCAGCC CCCGCCCAGG CCCTGTAGGG 1320

ACAGCATTTG AAGGACACAT ATTGCAGTTG CTTGGTTGAA AGTGCCTGTG CTGGAACTGG 1380 CCTGTACTCA CTCATGGGAG CTGGCCCC

25

Seq ID NO: 603 Protein sequence Protein Accession ft: NP 003967.1

__ 1 11 21 31 41 51

30 i i i i i i

MELGLGGLST LSHCPWPRRQ PALWPTLAAL ALLSSVAEAS LGSAPRSPAP REGPPPVLAS 60

PAGHLPGGRT ARWCSGRARR PPPQPSRPAP PPPAPPSALP RGGRAARAGG PGSRARAAGA 120

^• RGCRLRSQLV PVRALGLGHR SDELVRFRFC SGSCRRARSP HDLSLASLLG AGALRPPPGS 180 RPVSQPCCRP TRYEAVSFMD VNSTWRTVDR LSATACGCLG

35

Seq ID NO: 604 DNA sequence

Nucleic Acid Accession ft: NM_057091.1

Coding sequence: 783..1445 0 1 11 21 31 41 51

1 1 ) 1 1 1

ACTGGCCGCT GAGAGAAGAA TCGGGTGGAG CAGAGAGCAG CTGCTGCAGG GCAGACAGCC 60

GGACCCCCAA ATCTGCACGT ACCAGCAGTC AGCCGCCCCA CGCAGGGACC GGCTTACCCC 120

TCGCTCCCCG CCCTCACTCA CTTTCTCCCG CCCTCGGCCC GGCCTCCCAG CTCTCTACTT 180 5 CGCGTGTCTA CAAACTCAAC TCCCGGTTTC CGTGCCTCTC CACCGCTCGA GTTCTCTACT 240

CTCCATATCC GAGGGGCCCC TCCCAGCATC TACCCCCCTC CCAACCTCGG GGGACCTAGC 300

CAAGCTAGGG GGGACTGGAT CCGACGGGTG GAGCAGCCAG GTGAGCCCCG AAAGGTGGGG 360

CGGGGCAGGG GCGCTCCCAG CCCCACCCCG GGATCTGGTG ACGCTGGGGC TGGAATTTGA 420

CACCGGACGG CTGCGGCGGC GGGCAGGAGG CTGCTGAGGG ATGGAGTTGG GCCCGGCCCC 480

50 CAGACAAGGC CCGGGGGCTC CGCCAGCAGC AGGTCCCTCG GGCCCCAGCC CTCGCTGCCA 540

CCCGGGCCTG GAGCCCCACA CCCGAGGGTG CAGACTGGCT GCCAAGGCCA CACTTTTGGC 600

TAAAAGAGGC ACTGCCAGGT GTACAGTCCT GGGCATGCGC TGTTTGAGCT TCGGGGGAGA 660

GCCCAGCACT GGTCCCCGGA AAGGTGCCTA GAAGAACAAG GTGCAGGACC CCGTGCTGCC 720

TCAACAGGAG GGTGGGGGAA CAGCTCAACA ATGGCTGATG GGCGCTCCTG GTGTTGATAG 780

55 AGATGGAACT TGGAGTTGGA GGCCTCTCCA CGCTGTCCCA CTGCCCCTGG CCTAGGCGGC 840

AGCCTGCCCT GTGGCCCACC CTGGCCGCTC TGGCTCTGCT GAGCAGCGTC GCAGAGGCCT 900

CCCTGGGCTC CGCGCCCCGC AGCCCTGCCC CCCGCGAAGG CCCCCCGCCT GTCCTGGCGT 960

CCCCCGCCGG CCACCTGCCG GGGGGACGCA CGGCCCGCTG GTGCAGTGGA AGAGCCCGGC 1020

GGCCGCCGCC GCAGCCTTCT CGGCCCGCGC CCCCGCCGCC TGCACCCCCA TCTGCTCTTC 1080 0 CCCGCGGGGG CCGCGCGGCG CGGGCTGGGG GCCCGGGCAG CCGCGCTCGG GCAGCGGGGG 1140

CGCGGGGCTG CCGCCTGCGC TCGCAGCTGG TGCCGGTGCG CGCGCTCGGC CTGGGCCACC 1200

GCTCCGACGA GCTGGTGCGT TTCCGCTTCT GCAGCGGCTC CTGCCGCCGC GCGCGCTCTC 1260

CACACGACCT CAGCCTGGCC AGCCTACTGG GCGCCGGGGC CCTGCGACCG CCCCCGGGCT 1320

CCCGGCCCGT CAGCCAGCCC TGCTGCCGAC CCACGCGCTA CGAAGCGGTC TCCTTCATGG 1380 5 ACGTCAACAG CACCTGGAGA ACCGTGGACC GCCTCTCCGC CACCGCCTGC GGCTGCCTGG 1440

GCTGAGGGCT CGCTCCAGGG CTTTGCAGAC TGGACCCTTA CCGGTGGCTC TTCCTGCCTG 1500

GGACCCTCCC GCAGAGTCCC ACTAGCCAGC GGCCTCAGCC AGGGACGAAG GCCTCAAAGC 1560

TGAGAGGCCC CTACCGGTGG GTGATGGATA TCATCCCCGA ACAGGTGAAG GGACAACTGA 1620

CTAGCAGCCC CAGAGCCCTC ACCCTGGGGA TCCCAGCCTA AAAGACACCA GAGACCTCAG 1680 0 CTATGGAGCC CTTCGGACCC ACTTCTCACA GACTCTGGCA CTGGCCAGGC CTCGAACCTG 1740

GGACCCCTCC TCTGATGAAC ACTACAGTGG CTGAGGCATC AGCCCCCGCC CAGGCCCTGT 1800

AGGGACAGCA TTTGAAGGAC ACATATTGCA GTTGCTTGGT TGAAAGTGCC TGTGCTGGAA 1860 CTGGCCTGTA CTCACTCATG GGAGCTGGCC CC 5 Seq ID NO: 605 Protein sequence Protein Accession ft: NP_003967.1

1 11 21 31 41 51 0 I I I I I I

MELGLGGLST LSHCPWPRRQ PALWPTLAAL ALLSSVAEAS LGSAPRSPAP REGPPPVLAS 60

PAGHLPGGRT ARWCSGRARR PPPQPSRPAP PPPAPPSALP RGGRAARAGG PGSRARAAGA 120

RGCRLRSQLV PVRALGLGHR SDELVRFRFC SGSCRRARSP HDLSLASLLG AGALRPPPGS 180 RPVSQPCCRP TRYEAVSFMD VNSTWRTVDR LSATACGCLG 5

Seq ID NO: 606 DNA sequence

Nucleic Acid Accession ft: NM_057160.1 Coding sequence: 1..714

1 11 21 31 41 51

A ITGCCCGGCC TIGATCTCAGC CICGAGGACAG CICCCTCCTTG AIGGTCCTTCC TICCCCAAGCC 60

CACCTGGGTG CCCTCTTTCT CCCTGAGGCT CCACTTGGTC TCTCCGCGCA GCCTGCCCTG 120

TGGCCCACCC TGGCCGCTCT GGCTCTGCTG AGCAGCGTCG CAGAGGCCTC CCTGGGCTCC 180

GCGCCCCGCA GCCCTGCCCC CCGCGAAGGC CCCCCGCCTG TCCTGGCGTC CCCCGCCGGC 240

CACCTGCCGG GGGGACGCAC GGCCCGCTGG TGCAGTGGAA GAGCCCGGCG GCCGCCGCCG 300

10 CAGCCTTCTC GGCCCGCGCC CCCGCCGCCT GCACCCCCAT CTGCTCTTCC CCGCGGGGGC 360

CGCGCGGCGC GGGCTGGGGG CCCGGGCAGC CGCGCTCGGG CAGCGGGGGC GCGGGGCTGC 420

CGCCTGCGCT CGCAGCTGGT GCCGGTGCGC GCGCTCGGCC TGGGCCACCG CTCCGACGAG 480

CTGGTGCGTT TCCGCTTCTG CAGCGGCTCC TGCCGCCGCG CGCGCTCTCC ACACGACCTC 540

AGCCTGGCCA GCCTACTGGG CGCCGGGGCC CTGCGACCGC CCCCGGGCTC CCGGCCCGTC 600

15 AGCCAGCCCT GCTGCCGACC CACGCGCTAC GAAGCGGTCT CCTTCATGGA CGTCAACAGC 660

ACCTGGAGAA CCGTGGACCG CCTCTCCGCC ACCGCCTGCG GCTGCCTGGG CTGAGGGCTC 720

GGTCCAGGGC TTTGCAGACT GGACCCTTAC CGGTGGCTCT TCCTGCCTGG GACCCTCCCG 780

CAGAGTCCCA CTAGCCAGCG GCCTCAGCCA GGGACGAAGG CCTCAAAGCT GAGAGGCCCC 840

TACCGGTGGG TGATGGATAT CATCCCCGAA CAGGTGAAGG GACAACTGAC TAGCAGCCCC 900

20 AGAGCCCTCA CCCTGCGGAT CCCAGCCTAA AAGACACCAG AGACCTCAGC TATGGAGCCC 960

TTCGGACCCA CTTCTCACAG ACTCTGGCAC TGGCCAGGCC TCGAACCTGG GACCCCTCCT 1020

CTGATGAACA CTACAGTGGC TGAGGCATCA GCCCCCGCCC AGGCCCTGTA GGGACAGCAT 1080

TTGAAGGACA CATATTGCAG TTGCTTGGTT GAAAGTGCCT GTGCTGGAAC TGGCCTGTAC 1140 TCACTCATGG GAGCTGGCCC C

25

Seq ID NO: 607 Protein sequence Protein Accession ft: NP 476501.1

1 11 21 31 41 51

30 i i i i i i

MPGLISARGQ PLLEVLPPQA HLGALFLPEA PLGLSAQPAL WPTLAALALL SSVAEASLGS 60

APRSPAPREG PPPVLASPAG HLPGGRTARW CSGRARRPPP QPSRPAPPPP APPSALPRGG 120

RAARAGGPGS RARAAGARGC RLRSQLVPVR ALGLGHRSDE LVRFRFCSGS CRRARSPHDL 180 SLASLLGAGA LRPPPGSRPV SQPCCRPTRY EAVSFMDVNS TWRTVDRLSA TACGCLG

35

Seq ID NO: 60B DNA sequence

Nucleic Acid Accession ft: NM_057090.1

Coding sequence: 29..715

40 1 11 21 31 41 51

I I I I I I

CTGATGGGCG CTCCTGGTGT TGATAGAGAT GGAACTTGGA CTTGGAGGCC TCTCCACGCT 60

GTCCCACTGC CCCTGGCCTA GGCGGCAGGC TCCACTTGGT CTCTCCGCGC AGCCTGCCCT 120

GTGGCCCACC CTGGCCGCTC TGGCTCTGCT GAGCAGCGTC GCAGAGGCCT CCCTGGGCTC 180

45 CGCGCCCCGC AGCCCTGCCC CCCGCGAAGG CCCCCCGCCT GTCCTGGCGT CCCCCGCCGG 240

CCACCTGCCG GGGGGACGCA CGGCCCGCTG GTGCAGTGGA AGAGCCCGGC GGCCGCCGCC 300

GCAGCCTTCT CGGCCCGCGC CCCCGCCGCC TGCACCCCCA TCTGCTCTTC CCCGCGGGGG 360

CCGCGCGGCG CGGGCTGGGG GCCCGGGCAG CCGCGCTCGG GCAGCGGGGG CGCGGGGCTG 420

CCGCCTGCGC TCGCAGCTGG TGCCGGTGCG CGCGCTCGGC CTGGGCCACC GCTCCGACGA 480

50 GCTGGTGCGT TTCCGCTTCT GCAGCGGCTC CTGCCGCCGC GCGCGCTCTC CACACGACCT 540

CAGCCTGGCC AGCCTACTGG GCGCCGGGGC CCTGCGACCG CCCCCGGGCT CCCGGCCCGT 600

CAGCCAGCCC TGCTGCCGAC CCACGCGCTA CGAAGCGGTC TCCTTCATGG ACGTCAACAG 660

CACCTGGAGA ACCGTGGACC GCCTCTCCGC CACCGCCTGC GGCTGCCTGG GCTGAGGGCT 720

CGCTCCAGGG CTTTGCAGAC TGGACCCTTA CCGGTGGCTC TTCCTGCCTG GGACCCTCCC 780

55 GCAGAGTCCC ACTAGCCAGC GGCCTCAGCC AGGGACGAAG GCCTCAAAGC TGAGAGGCCC 840

CTACCGGTGG GTGATGGATA TCATCCCCGA ACAGGTGAAG GGACAACTGA CTAGCAGCCC 900

CAGAGCCCTC ACCCTGGGGA TCCCAGCCTA AAAGACACCA GAGACCTCAG CTATGGAGCC 60

CTTCGGACCC ACTTCTCACA GACTCTGGCA CTGGCCAGGC CTCGAACCTG GGACCCCTCC 1020

TCTGATGAAC ACTACAGTGG CTGAGGCATC AGCCCCCGCC CAGGCCCTGT AGGGACAGCA 1080

60 TTTGAAGGAC ACATATTGCA GTTGCTTGGT TGAAAGTGCC TGTGCTGGAA CTGGCCTGTA 1140 CTCACTCATG GGAGCTGGCC CC

Seq ID NO: 609 Protein sequence Protein Accession ft: NP_476431.1

65

1 11 21 31 41 51

I I I I I I

MELGLGGLST LSHCPWPRRQ APLGLSAQPA LWPTLAALAL LSSVAEASLG SAPRSPAPRE 60

GPPPVLASPA GHLPGGRTAR WCSGRARRPP PQPSRPAPPP PAPPSALPRG GRAARAGGPG 120

70 SRARAAGARG CRLRSQLVPV RALGLGHRSD ELVRFRFCSG SCRRARSPHD LSLASLLGAG 180 ALRPPPGSRP VSQPCCRPTR YEAVSFMDVN STWRTVDRLS ATACGCLG

Seq ID NO : 610 DNA sequence Nucleic Acid Accession ft : Eos sequence I D Coding sequence : 1 . .1746

1 11 21 31 41 51

I I I I I I

ATGCCACTGA AGCATTATCT CCTTTTGCTG GTGGGCTGCC AAGCCTGGGG TGCAGGGTTG 60 0 GCCTACCATG GCTGCCCTAG CGAGTGTACC TGCTCCAGGG CCTCCCAGGT GGAGTGCACC 120

GGGGCACGCA TTGTGGCGGT GCCCACCCCT CTGCCCTGGA ACGCCATGAG CCTGCAGATC 180

CTCAACACGC ACATCACTGA ACTCAATGAG TCCCCGTTCC TCAATATCTC AGCCCTCATC 240

GCCCTGAGGA TTGAGAAGAA TGAGCTGTCG CGCATCACGC CTGGGGCCTT CCGAAACCTG 300

GGCTCGCTGC GCTATCTCAG CCTCGCCAAC AACAAGCTGC AGGTTCTGCC CATCGGCCTC 360 5 TTCCAGGGCC TGGACAGCCT TGAGTCTCTC CTTCTGTCCA GTAACCAGCT GTTGCAGATC 420

CAGCCGGCCC ACTTCTCCCA GTGCAGCAAC CTCAAGGAGC TGCAGTTGCA CGGCAACCAC 480

CTGGAATACA TCCCTGACGG AGCCTTCGAC CACCTGGTAG GACTCACGAA GCTCAATCTG 540 GGCAAGAATA GCCTCACCCA CATCTCACCC AGGGTCTTCC AGCACCTGGG CAATCTCCAG 600

GTCCTCCGGC TGTATGAGAA CAGGCTCACG GATATCCCCA TGGGCACTTT TGATGGGCTT 660

GTTAACCTGC AGGAACTGGC TCTACAGCAG AACCAGATTG GACTGCTCTC CCCTGGTCTC 720

TTCCACAACA ACCACAACCT CCAGAGACTC TACCTGTCCA ACAACCACAT CTCCCAGCTG 780

CCACCCAGCA TCTTCATGCA GCTGCCCCAG CTCAACCGTC TTACTCTCTT TGGGAATTCC 840

CTGAAGGAGC TCTCTCTGGG GATCTTCGGG CCCATGCCCA ACCTGCGGGA GCTTTGGCTC 900

TATGACAACC ACATCTCTTC TCTACCCGAC AATGTCTTCA GCAACCTCCG CCAGTTGCAG 960

GTCCTGATTC TTAGCCGCAA TCAGATCAGC TTCATCTCCC CGGGTGCCTT CAACGGGCTA 1020

ACGGAGCTTC GGGAGCTGTC CCTCCACACC AACGCACTGC AGGACCTGGA CGGGAATGTC 1080

TTCCGCATGT TGGCCAACCT GCAGAACATC TCCCTGCAGA ACAATCGCCT CAGACAGCTC 1140

CCAGGGAATA TCTTCGCCAA CGTCAATGGC CTCATGGCCA TCCAGCTGCA GAACAACCAG 1200

CTGGAGAACT TGCCCCTCGG CATCTTCGAT CACCTGGGGA AACTGTGTGA GCTGCGGCTG 1260

TATGACAATC CCTGGAGGTG TGACTCAGAC ATCCTTCCGC TCCGCAACTG GCTCCTGCTC 1320

AACCAGCCTA GGTTAGGGAC GGACACTGTA CCTGTGTGTT TCAGCCCAGC CAATGTCCGA 1380

GGCCAGTCCC TCATTATCAT CAATGTCAAC GTTGCTGTTC CAAGCGTCCA TGTCCCTGAG 1440

GTGCCTAGTT ACCCAGAAAC ACCATGGTAC CCAGACACAC CCAGTTACCC TGACACCACA 1500

TCCGTCTCTT CTACCACTGA GCTAACCAGC CCTGTGGAAG ACTACACTGA TCTGACTACC 1560

ATTCAGGTCA CTGATGACCG CAGCGTTTGG GGCATGACCC AGGCCCAGAG CGGGCTGGCC 1620

ATTGCCGCCA TTGTAATTGG CATTGTCGCC CTGGCCTGCT CCCTGGCTGC CTGCGTCGGC 1680

TGTTGCTGCT GCAAGAAGAG GAGCCAAGCT GTCCTGATGC AGATGAAGGC ACCCAATGAG 1740

TGTTAAAGAG GCAGGCTGGA GCAGGGCTGG GGAATGATGG GACTGGAGGA CCTGGGAATT 1800

TCATCTTTCT GCCTCCACCC CTGGGTCCAT GGAGCTTTCC CGTGATTGCT CTTTCTGGCC 1860

CTAGATAAAG GTGTGCCTAC CTCTTCCTGA CTTGCCTGAT TCTCCCGTAG AGAAGCAGGT 1920

CGTGCCGGAC CTTCCTACAA TCAGGAAGAT AGATCCAACT GGCCATGGCA AAAGCCCTGG 1980

GGATTTCCGA TTCATACCCC TGGGCTTCCT TCGAGAGGGC TCTTCCTCCA AATCCTCCCC 2040

ACCTGTCCTC CAAGAACAGC CTTCCCTGCG CCCAGGCCCC CTCCGGGCCT CTGTAGACTC 2100

AGTTAGTCCA CAGCCTGCTC ACTTCGTGGG AATAGTTCTC CGCTGAGATA GCCCCTCTCG 2160

CCTAAGTATT ATGTAAGTTG ATTTCCCTTC TTTTGTTTCT CTTGTTTGTG CTATGGCTTG 2220

ACCCAGCATG TCCCCTCAAA TGAAAGTTCT CCCCTTGATT TTCTGCTCCT GAAGGCAGGG 2280

TGAGTTCTCT CCTCAAAGAA GACTTCAAAC CATTTAACTG GTTTCTTAAG AGCCGTCAAT 2340

CAGCCTGGTT TTGGGGATGC TATGAAAGAG AGAAGGAAAA TCATGCCGCT CAGTTCCTGG 2400

AGACAGAAGA GCCGTCATCA GTGTCTCACT TGTGATTTTT ATCTGGAAAA GGAAGAAACA 2460

CCCCAGCACA GCAAGCTCAG CCTTTTAGAG AAGGATATTT CCAAACTGCA AACTTTGCTT 2520

TGAAAAGTTT AGCCCTTTAA GGAATGAAAT CATGTAGAAT TTTGGACTTC TAAAAACATT 2580

AAAATCAGCT TATTAATACG GGATAGAGAA AGAAATCTGG TGCCTGGGGG TCCCTGTGTT 2640

CACCCCTAGA GTTTGTTTTA AAATTTTTAA TTGAAGCATG TGAAGTGTAC STGCAGAAAA 2700

GTGGGAACAT GATAGTGTAT GGCTTGGTGG ATTTTCACAA ACTGAACATA CCTGTGTAAT 2760

CAGCATCTAG ACCCAGACCC AGAGCATCAC AAATATCCCC CATCCTGGGC TTTTCCCAGA 2820

GGAGATGGGG GCTTCTGAAG ATGGACTTAC CTGGGACCTG CCCCCCATGA GCCAGGACGG 2880

TCCCCCCACA GTCAGCCTGT GCAAAGGCCC CGTGGCCAGG GGTGGAGGAG AATATGTGGG 2940

TGTGGACAGG ATGGGAGACT GTGGCCTGAA CAGGAGATTT TATTATATCT GGAGACCCTG 3000

AGAGACCCTG AGACCTGGGG CACCATGGCT GGCCAGGTCA GAAGCATCCT GACTGCAGAG 3060

GTCCGTGCAG CCACACCCTC TTCCCTGCCA GCAAGTTGTC TGCGGCTCAT CGGAGGCCCC 3120

TCCGCCTGGA GCCTTCTATG GACGTGATAT GCCTGTATCT GTTTTTAATT TTCATTCTTC 3180

ACTTAGGGGA AGTGAAATCG CTCAGAGATG AGATCCTTTA ATTGAAAACG AAGTGTAACG 3240

GAATCTAGTG TCTTTCTAAT GTGGTAAAAT TCTCCATCAA CATCACAGTC AGCTGGCAGC 3300

TGAACTTCAG AATCTCACTT ACAGCAGGCG ACACGGGGGT ACACCGATGG GTCACACTGG 3360

GTCTGGGGGC TCCCTGGAGC TCCTCCTGCG TGTGGTCTGG TTAGGAGTTG AGTTGTTTGC 3420

TCCAGGGTTA TTCTCCTCCT CGAGTCACAG TCACACGAAT ACCTGCCTTC TCTGGCTTTC 3480

CTGCTATACA CATATTCACA TGGCGCTCAA GAAGTTAGGC TCATGGCAAC GTGTGTCTTT 3540

CTCTGGACAA CTGGCCCAGT TTACAGTGAA ATGGAGAATT TCAGGTCTCC ACGTCTGCCC 3600

AGGAAAGAAC TTCAGCTGAC TCCACGGGGA TCTGGAAATC CACGACCAAT CCCGATCGGC 3660

TCTTATTAGC TCCCCGCTCC ACAAGACACC TGTGCTTTGG AAATCCACCA CCAATCCCGA 3720

TCGGCTCTTA TTAGCTCCCC GCTCCACAAG ACACCTGTGA TCTGGAAATC TACCACCAAT 3780

CCCGATCGGC TCTTATTAGC TCCCCGCTCC ACAAGACACC TGTGACATCC TCCAGGGCCA 3840

CAGGAGCACG TGCTGACCAG TTTTCCCTTC CAGTTCCTGC ACAAAAAGTG TCCAGAGGGC 3900

TGTTTGCAAA CACTAGTGCA CTTTGTAGCT TTTCACCCTC TGTCCCAGGG AATCTAGGAG 3960

AGATGAGGCC CGTCAGAGTC AAGAGATGTC ATCCCCCCAG GGTCTCCAAG GCATTTCCAC 4020

ACTATTGGTG GCACCTGGAG GACATGCACC AAGGCTTGCC AGAGCCAACA GGAAGTGAGC 4080

CCAGAGCATG GCACATGAGC ATCACCCGCT GATGGTGGCC TGCTGTGCCT GGTGCCAACA 4140

GGGGCATCCC GGCCCGTACC CCTCCAGACA GGAAGCATGG GTTTGCCCAC AGACCTGTCG 4200

GGTGCTCCTG TGAGTGGCCT CCAGATGTCT TTGTGCATAG GCACAAGTGG GCCAGGGCTG 4260

GAGGGAGGTG GGAAACCTCA TCATCCGGTG GGCCCTGCCA ATCTTAACCC AGAACCCTTA 4320

GGTATTCCTG GCAGTAGCCA TGACATTGGA GCACCTTCCT CTCCAGCCAG AGGCTGACCT 4380

GAGGGCCACT GTCCTCAGAT GACACCACCC AGGAGCACCC TAGGTGAGGG GTGAGGGCCC 4440

CCTTATGTGA ACCTCTTGCC TCTTCCTTTC TCCCATCAGA GTGGTTGGAT GGAGCCATTG 4500

GCCTCCTTTT CTTCAGCGGG CCCTTCAACC TCTCTGCACC ATGTTGTCTG GCTGAGGAGC 4560

TACTAGAAAA GCTGAGTGGA GTCTCCTTTC CAACAGGATG ATGCATTTGC TCAATTCTCA 4620

GGGCTGGAAT GAGCCGGCTG GTCCCCCAGA AAGCTGGAGT GGGGTACAGA GTTCAGTTTT 4680

CCTCTCTGTT TACAGCTCCT TGACAGTCCC ACGCCCATCT GGAGTGGGAG CTGGGAGTTA 4740

CTGTTGGAGA AGAAACAACA AAAGCCAATT AGAACCACTA TTTTTAAAAA GTGCTTACTG 4800

TGCACAGATA CTCTTCAAGC ACTGGACGTG GATTCTCTCT CTAGCCCTCA GCACCCCTGC 4860

GGTAGGAGTG CCGCCTCTAC CCACTTGTGA TGGGGTACAG AGGCACTTGC TCTTCTGCAT 4920

GGTGTTCAAT AGGCTGGGAG TTTTATTTAT CTCTTCAAAC TTTGTACAAG AGCTCATGGC 4980

TTGTCTTGGG CTTTCGTCAT TAAACCAAAG GAAATGGAAG CCATTCCCCT GTTGCTCTCC 5040

TTAGTCTTGG TCATCAGAAC CTCACTTGGT ACCATATAGA TCAAAAGCTT TGTAACCACA 5100

GGAAAAAATA AACTCTTCCA TCCCTTAAAG AATAGAATAG TTTGTCCCTC TCATGGGAAT 5160

TGGGCTGTAT GTATATTGTT CTTCCTCCTT AGAATTTAGA GATACAAGAG TTCTACTTAG 5220

AACTTTTCAT GGACACAATT TCCACAACCT TTCAGATGGT GATGTAGAGC TATTGGGAAA 5280

GAACTTCCAA ACTCAGGAAG TTTGCAGAGA GCAGACAGCT AGAGATAACT CGGGACCCAG 5340

AGTTGGTCGA CAGATGTTAG ATGTATCCTA GCTTTTAGCC ATAAACCACT CAAAGATTCA 5400

GCCCCCAGAT CCCACAGTCA GAACTGAATC TGCGTTGTTG GGAAGCCAGC AGTGGCCTTG 5460

GGAAGGAAGC CATGGCTGTG GTTCAGAGAG GGTGGGCTGG CAAGCCACTT CCGGGGAAAA 5520

CTCCTTCCGC CCCAGGTTTC TTCTTCTCTT AAGGAGAGAT TGTTCTCACC AACCCGCTGC 5580

GTTCATGCTG CCTTCAAAGC TAGATCATGT TTGCCTTGCT TAGAGAATTA CTGCAAATCA 5640

GCCCCAGTGC TTGGCGATGC ATTTACAGAT TTCTAGGCCC TCAGGGTTTT GTAGAGTGTG 5700

AGCCCTGGTG GGCAGGGTTG GGGGGTCTGT CTTCTGCTGG ATGCTGCTTG TAATCCATTT 5760 GGTGTACAGA ATCAACAATA AATAATATAC ATGTAT

Seq ID NO: 611 Protein sequence Protein Accession ft: BAB84587.1

1 11 21 31 41 51

I I I I I I

MPLKHYLLLL VGCQAWGAGL AYHGCPSECT CSRASQVECT GARIVAVPTP LPWNAMSLQI 60

LNTHITELNE SPFLNISALI ALRIEKNELS RITPGAFRNL GSLRYLSLAN NKLQVLPIGL 120

FQGLDSLESL LLSSNQLLQI QPAHFSQCSN LKELQLHGNH LEYIPDGAFD HLVGLTKLNL 180

GKNSLTHISP RVFQHLGNLQ VLRLYENRLT DIPMGTFDGL VNLQELALQQ NQIGLLSPGL 240

FHNNHNLQRL YLSNNHISQL PPSIFMQLPQ LNRLTLFGNS LKELSLGIFG PMPNLRELWL 300

YDNHISSLPD NVFSNLRQLQ VLILSRNQIS FISPGAFNGL TELRELSLHT NALQDLDGNV 360

FRMLANLQNI SLQNNRLRQL PGNIFANVNG LMAIQLQNNQ LENLPLGIFD HLGKLCELRL 420

YDNPWRCDSD ILPLRNWLLL NQPRLGTDTV PVCFSPANVR GQSLIIINVN VAVPSVHVPE 480

VPSYPETPWY PDTPSYPDTT SVSSTTELTS PVEDYTDLTT IQVTDDRSVW GMTQAQSGLA 540 IAAIVIGIVA LACSLAACVG CCCCKKRSQA VLMQMKAPNE C

Seq ID NO: 612 DNA sequence Nucleic Acid Accession ft: XM_og8151 Coding sequence: 1..447

1 11 21 31 41 51

A ITGATGCATT TIGCTCAATTC TICAGGGCTGG AIATGAGCCGG CITGGTCCCCC AIGAAAGCTGG 60

AGTGGGGTAC AGAGTTCAGT TTTCCTCTCT GTTTACAGCT CCTTGACAGT CCCACGCCCA 120

TCTGGAGTGG GAGCTGGGAG TCAGTGTTGG AGAAGAAACA ACAAAAGCCA ATTAGAACCA 180

CTATTTTTAA AAAGTGCTTA CTGTGCACAG ATACTCTTCA AGCACTGGAC GTGGATTCTC 240

TCTCTAGCCC TCAGCACCCC TGCGGTAGGA GTGCCGCCTC TACCCACTTG TGATGGGGTA 300

CAGAGGCACT TGCTCTTCTG CATGGTGTTC AATAGGCTGG GAGTTTTATT TATCTCTTCA 360

AACTTTGTAC AAGAGCTCAT GGCTTGTCTT GGGCTTTCGT CATTAAACCA AAGGAAATGG 420 AAGCCATTCC CCTGTTGCTC TCCTTAG

Seq ID NO: 613 Protein sequence Protein Accession ft: XP_098151

1 11 21 31 41 51

I I I I I I

MMHLLNSQGW NEPAGPPESW SGVQSSVFLS VYSSLTVPRP SGVGAGSQCW RRNNKSQLEP 60

LFLKSAYCAQ ILFKHWTWIL SLALSTPAVG VPPLPTCDGV QRHLLFCMVF NRLGVLFISS 120 NFVQELMACL GLSSLNQRKW KPFPCCSP

Seq ID NO: 614 DNA sequence

Nucleic Acid Accession ft: NM_002658.1

Coding sequence: 77..1372

1 11 21 31 41 51

I I I I I I

GTCCCCGCAG CGCCGTCGCG CCCTCCTGCC GCAGGCCACC GAGGCCGCCG CCGTCTAGCG 60

CCCCGACCTC GCCACCATGA GAGCCCTGCT GGCGCGCCTG CTTCTCTGCG TCCTGGTCGT 120

GAGCGACTCC AAAGGCAGCA ATGAACTTCA TCAAGTTCCA TCGAACTGTG ACTGTCTAAA 180

TGGAGGAACA TGTGTGTCCA ACAAGTACTT CTCCAACATT CACTGGTGCA ACTGCCCAAA 240

GAAATTCGGA GGGCAGCACT GTGAAATAGA TAAGTCAAAA ACCTGCTATG AGGGGAATGG 300

TCACTTTTAC CGAGGAAAGG CCAGCACTGA CACCATGGGC CGGCCCTGCC TGCCCTGGAA 360

CTCTGCCACT GTCCTTCAGC AAACGTACCA TGCCCACAGA TCTGATGCTC TTCAGCTGGG 420

CCTGGGGAAA CATAATTACT GCAGGAACCC AGACAACCGG AGGCGACCCT GGTGCTATGT 480

GCAGGTGGGC CTAAAGCCGC TTGTCCAAGA GTGCATGGTG CATGACTGCG CAGATGGAAA 540

AAAGCCCTCC TCTCCTCCAG AAGAATTAAA ATTTCAGTGT GGCCAAAAGA CTCTGAGGCC 600

CCGCTTTAAG ATTATTGGGG GAGAATTCAC CACCATCGAG AACCAGCCCT GGTTTGCGGC 660

CATCTACAGG AGGCACCGGG GGGGCTCTGT CACCTACGTG TGTGGAGGCA GCCTCATCAG 720

CCCTTGCTGG GTGATCAGCG CCACACACTG CTTCATTGAT TACCCAAAGA AGGAGGACTA 780

CATCGTCTAC CTGGGTCGCT CAAGGCTTAA CTCCAACACG CAAGGGGAGA TGAAGTTTGA 840

GGTGGAAAAC CTCATCCTAC ACAAGGACTA CAGCGCTGAC ACGCTTGCTC ACCACAACGA 900

CATTGCCTTG CTGAAGATCC GTTCCAAGGA GGGCAGGTGT GCGCAGCCAT CCCGGACTAT 960

ACAGACCATC TGCCTGCCCT CGATGTATAA CGATCCCCAG TTTGGCACAA GCTGTGAGAT 1020

CACTGGCTTT GGAAAAGAGA ATTCTACCGA CTATCTCTAT CCGGAGCAGC TGAAAATGAC 1080

TGTTGTGAAG CTGATTTCCC ACCGGGAGTG TCAGCAGCCC CACTACTACG GCTCTGAAGT 1140

CACCACCAAA ATGCTATGTG CTGCTGACCC CCAATGGAAA ACAGATTCCT GCCAGGGAGA 1200

CTCAGGGGGA CCCCTCGTCT GTTCCCTCCA AGGCCGCATG ACTTTGACTG GAATTGTGAG 1260

CTGGGGCCGT GGATGTGCCC TGAAGGACAA GCCAGGCGTC TACACGAGAG TCTCACACTT 1320

CTTACCCTGG ATCCGCAGTC ACACCAAGGA AGAGAATGGC CTGGCCCTCT GAGGGTCCCC 1380

AGGGAGGAAA CGGGCACCAC CCGCTTTCTT GCTGGTTGTC ATTTTTGCAG TAGAGTCATC 1440

TCCATCAGCT GTAAGAAGAG ACTGGGAAGA TAGGCTCTGC ACAGATGGAT TTGCCTGTGG 1500

CACCACCAGG GTGAACGACA ATAGCTTTAC CCTCACGGAT AGGCCTGGGT GCTGGCTGCC 1560

CAGACCCTCT GGCCAGGATG GAGGGGTGGT CCTGACTCAA CATGTTACTG ACCAGCAACT 1620

TGTCTTTTTC TGGACTGAAG CCTGCAGGAG TTAAAAAGGG CAGGGCATCT CCTGTGCATG 1680

GGCTCGAAGG GAGAGCCAGC TCCCCCGACC GGTGGGCATT TGTGAGGCCC ATGGTTGAGA 1740

AATGAATAAT TTCCCAATTA GGAAGTGTAA GCAGCTGAGG TCTCTTGAGG GAGCTTAGCC 1800

AATGTGGGAG CAGCGGTTTG GGGAGCAGAG ACACTAACGA CTTCAGGGCA GGGCTCTGAT 1860

ATTCCATGAA TGTATCAGGA AATATATATG TGTGTGTATG TTTGCACACT TGTTGTGTGG 1920

GCTGTGAGTG TAAGTGTGAG TAAGAGCTGG TGTCTGATTG TTAAGTCTAA ATATTTCCTT 1980

AAACTGTGTG GACTGTGATG CCACACAGAG TGGTCTTTCT GGAGAGGTTA TAGGTCACTC 2040

CTGGGGCCTC TTGGGTCCCC CACGTGACAG TGCCTGGGAA TGTACTTATT CTGCAGCATG 2100

ACCTGTGACC AGCACTGTCT CAGTTTCACT TTCACATAGA TGTCCCTTTC TTGGCCAGTT 2160

ATCCCTTCCT TTTAGCCTAG TTCATCCAAT CCTCACTGGG TGGGGTGAGG ACCACTCCTT 2220

ACACTGAATA TTTATATTTC ACTATTTTTA TTTATATTTT TGTAATTTTA AATAAAAGTG 2280 ATCAATAAAA TGTGATTTTT CTGA Seq ID NO: 615 Protein sequence Protein Accession ft: NP_002649.1

1 11 21 31 41 51

I I 1 I I I

MRALLARLLL CVLWSDSKG SNELHQVPSN CDCLNGGTCV SNKYFSNIHW CNCPKKFGGQ 60

HCEIDKSKTC YEGNGHFYRG KASTDTMGRP CLPWNSATVL QQTYHAHRSD ALQLGLGKHN 120

YCRNPDNRRR PWCYVQVGLK PLVQECMVHD CADGKKPSSP PEELKFQCGQ KTLRPRFKII 180

GGEFTTIENQ PKFAAIYRRH RGGSVTYVCG GSLISPCKVI SATHCFIDYP KKEDYIVYLG 240

RSRLNSNTQG EMKFEVENLI LHKDYSADTL AHHNDIALLK IRSKEGRCAQ PSRTIQTICL 300

PSMYNDPQFG TSCEITGFGK ENSTDYLYPE QLKMT KLI SHRECQQPHY YGSEVTTKML 360

CAADPQWKTD SCQGDSGGPL VCSLQGRMTL TGIVSWGRGC ALKDKPGVYT RVSHFLPWIR 420 SHTKEENGLA L

Seq ID NO: 616 DNA sequence

Nucleic Acid Accession ft: NM_024422.1

Coding sequence- 202..2907

1 11 21 31 41 51

I I 1 1 I I

CGCCAAAGGA AAAGCCCCTT GGATGAGAGG CAGGCGCTTC AGAGAAGCTA AGAAAAGCAC 60

CTCTCCGCGC GCCCCACCTC CTCCGCCTCG CGCTCCTCCT GAGCAGCGGG CCCAGACTGC 120

GCTCCGGCCG CGGCCCTCGC CCCGCGGAGC CCTCCTACCC CGGCCCGACG CTCGGCCCGC 180

GACCTGCCCC GAGCCCTCTC CATGGAGGCA GCCCGCCCCT CCGGCTCCTG GAACGGAGCC 240

CTCTGCCGGC TGCTCCTGCT GACCCTCGCG ATCTTAATAT TTGCCAGTGA TGCCTGCAAA 300

AATGTGACAT TACATGTTCC CTCCAAACTA GATGCCGAGA AACTTGTTGG TAGAGTTAAC 360

CTGAAAGAGT GCTTTACAGC TGCAAATCTA ATTCATTCAA GTGATCCTGA CTTCCAAATT 420

TTGGAGGATG GTTCAGTCTA TACAACAAAT ACTATTCTAT TGTCCTCGGA GAAGAGAAGT 480

TTTACCATAT TACTTTCCAA CACTGAGAAC CAAGAAAAGA AGAAAATATT TGTCTTTTTG 540

GAGCATCAAA CAAAGGTCCT AAAGAAAAGA CATACTAAAG AAAAAGTTCT AAGGCGCGCC 600

AAGAGAAGAT GGGCTCCAAT TCCTTGTTCG ATGCTAGAAA ACTCCTTGGG TCCTTTTCCA 660

CTTTTCCTTC AACAGGTTCA ATCTGACACG GCCCAAAACT ATACCATATA CTATTCCATA 720

AGAGGTCCTG GAGTTGACCA AGAACCTCGG AATTTATTTT ATGTGGAGAG AGACACTGGA 780

AACTTGTATT GTACTCGTCC TGTAGATCGT GAGCAGTATG AATCTTTTGA GATAATTGCC 840

TTTGCAACAA CTCCAGATGG GTATACTCCA GAACTTCCAC TGCCCCTAAT AATCAAAATA 900

GAGGATGAAA ATGATAACTA CCCAATTTTT ACAGAAGAAA CTTATACTTT TACAATTTTT 960

GAAAATTGCA GAGTGGGCAC TACTGTGGGA CAAGTGTOTG CTACTGACAA AGATGAGCCT 1020

GACACGATGC ACACACGCCT GAAGTACTCC ATCATTGGGC AGGTGCCACC ATCACCCACC 1080

CTATTTTCTA TGCATCCAAC TACAGGCGTG ATCACCACAA CATCATCTCA GCTAGACAGA 1140

GAGTTAATTG ACAAGTACCA GTTGAAAATA AAAGTACAAG ACATGGATGG TCAGTATTTT 1200

GGTCTACAGA CAACTTCAAC TTGTATCATT AACATTGATG ATGTAAATGA CCACTTGCCA 1260

ACATTTACTC GTACTTCTTA TGTGACATCA GTGGAAGAAA ATACAGTTGA TGTGGAAATC 1320

TTACGAGTTA CTGTTGAGGA TAAGGACTTA GTGAATACTG CTAACTGGAG AGCTAATTAT 1380

ACCATTTTAA AGGGCAATGA AAATGGCAAT TTTAAAATTG TAACAGATGC CAAAACCAAT 1440

GAAGGAGTTC TTTGTGTAGT TAAGCCTTTG AATTATGAAG AAAAGCAACA GATGATCTTG 1500

CAAATTGGTG TAGTTAATGA AGCTCCATTT TCCAGAGAGG CTAGTCCAAG ATCAGCCATG 1560

AGCACAGCAA CAGTTACTGT TAATGTAGAA GATCAGGATG AGGGCCCTGA GTGTAACCCT 1620

CCAATACAGA CTGTTCGCAT GAAAGAAAAT GCAGAAGTGG GAACAACAAG CAATGGATAT 1680

AAAGCATATG ACCCAGAAAC AAGAAGTAGC AGTGGCATAA GGTATAAGAA ATTAACTGAT 1740

CCAACAGGGT GGGTCACCAT TGATGAAAAT ACAGGATCAA TCAAAGTTTT CAGAAGCCTG 1800

GATAGAGAGG CAGAGACCAT CAAAAATGGC ATATATAATA TTACAGTCCT TGCATCAGAC 1860

CAAGGAGGGA GAACATGTAC GGGGACACTG GGCATTATAC TTCAAGACGT GAATGATAAC ig20

AGCCCATTCA TACCTAAAAA GACAGTGATC ATCTGCAAAC CCACCATGTC ATCTGCGGAG lgβO

ATTGTTGCGG TTGATCCTGA TGAGCCTATC CATGGCCCAC CCTTTGACTT TAGTCTGGAG 2040

AGTTCTACTT CAGAAGTACA GAGAATGTGG AGACTGAAAG CAATTAATGA TACAGCAGCA 2100

CGTCTTTCCT ATCAGAATGA TCCTCCATTT GGCTCATATG TAGTACCTAT AACAGTGAGA 2160

GATAGACTTG GCATGTCTAG TGTCACTTCA TTGGATGTTA CACTGTGTGA CTGCATTACC 2220

GAAAATGACT GCACACATCG TGTAGATCCA AGGATTGGCG GTGGAGGAGT ACAACTTGGA 2280

AAGTGGGCCA TCCTTGCAAT ATTGTTGGGC ATAGCATTGC TCTTTTGCAT CCTGTTTACG 2340

CTGGTCTGTG GGGCTTCTGG GACGTCTAAA CAACCAAAAG TAATTCCTGA TGATTTAGCC 2400

CAGCAGAACC TAATTGTATC AAACACAGAA GCTCCTGGAG ATGACAAAGT GTATTCTGCG 2460

AATGGCTTCA CAACCCAAAC TGTGGGCGCT TCTGCTCAGG GAGTTTGTGG CACCGTGGGA 2520

TCAGGAATCA AAAACGGAGG TCAGGAGACC ATCGAAATGG TGAAAGGAGG ACACCAGACC 2580

TCGGAATCCT GCCGGGGGGC TGGCCACCAT CACACCCTGG ACTCCTGCAG GGGAGGACAC 2640

ACGGAGGTGG ACAACTGCAG ATACACTTAC TCGGAGTGGC ACAGTTTTAC TCAGCCCCGT 2700

CTTGGTGAAA AAGTGTATCT GTGTAATCAA GATGAAAATC ACAAGCATGC CCAAGACTAT 2760

GTCCTGACAT ATAACTATGA AGGAAGAGGA TCGGTGGCTG GGTCTGTAGG TTGTTGCAGT 2820

GAACGACAAG AAGAAGATGG GCTTGAATTT TTGGATAATT TGGAGCCCAA ATTTAGGACA 2880

CTAGCAGAAG CATGCATGAA GAGATGAGTG TGTTCTAATA AGTCTCTGAA AGCCAGTGGC 2 40

TTTATGACTT TTAAAAAAAA TTACAAACCA AGAATTTTTT AAAGCAGAAG ATGCTATTTG 3000

TGGGGGTTTT TCTCTCATTA TTTGGATGGA ATCTCTTTGG TCAAATGCAC ATTTACAGAG 3060

AGACACTATA AACAAGTACA CAAATTTTTC AATTTTTACA TATTTTTAAA TTACTTATCT 3120

TCTATCCAAG GAGGTCTACA GAGAAATTAA AGTCTGCCTT ATTTGTTACA TTTGGGTATA 3180

ATGACAACAG CCAATTTATA GTGCAATAAA ATGTAATTAA TTCAAGTCCT TATTATAGAC 3240

TATTTGAAGC ACAACCTAAT GGAAAATTGT AGAGACCTTG CTTTAACATT ATCTCCAGTT 3300

AATTAAGTGT TCATGTGGTG CTTGGAAACT GTTGTTTTCC TGAACATCTA AAGTGTGTAG 3360

ACTGCATTCT TGCTATTATT TTATTCTTGT AATGTGACCT TTTCACTGTG CAAAGGGAGA 3420 TTTCTAGCCA GGCATTGACT ATTACAATTT CATT

Seq ID NO: 617 Protein sequence Protein Accession ft: NP 077740.1 1 11 21 31 41 51 i i i i i i

MEAARPSGSW NGALCRLLLL TLAILIFASD ACKNVTLHVP SKLDAEKLVG RVNLKECFTA 60 ANLIHSSDPD FQILEDGSVY TTNTILLSSE KRSFTILLSN TENQEKKKIF VFLEHQTKVL 120 KKRHTKEKVL RRAKRRWAPI PCSMLENSLG PFPLFLQQVQ SDTAQNYTIY YSIRGPGVDQ 180

EPRNLFYVER DTGNLYCTRP VDREQYESFE IIAFATTPDG YTPELPLPLI IKIEDENDNY 240

PIFTEETYTF TIFENCRVGT TVGQVCATDK DEPDTMHTRL KYSIIGQVPP SPTLFSMHPT 300

TGVITTTSSQ LDRELIDKYQ LKIKVQDMDG QYFGLQTTST CIINIDDVND HLPTFTRTSY 360

VTSVEENTVD VEILRVTVED KDLVNTANWR ANYTILKGNE NGNFKIVTDA KTNEGVLCW 420

KPLNYEEKQQ MILQIGWNE APFSREASPR SAMSTATVTV NVEDQDEGPE CNPPIQTVRM 480

KENAEVGTTS NGYKAYDPET RSSSGIRYKK LTDPTGWVTI DENTGSIKVF RSLDREAETI 540

KNGIYNITVL ASDQGGRTCT GTLGIILQDV NDNSPFIPKK TVIICKPTMS SAEIVAVDPD 600

EPIHGPPFDF SLESSTSEVQ RMWRLKAIND TAARLSYQND PPFGSYWPI TVRDRLGMSS 660

VTSLDVTLCD CITENDCTHR VDPRIGGGGV QLGKWAILAI LLGIALLFCI LFTLVCGASG 720

TSKQPKVIPD DLAQQNLIVS NTEAPGDDKV YSANGFTTQT VGASAQGVCG TVGSGIKNGG 780

QETIEMVKGG HQTSESCRGA GHHHTLDSCR GGHTEVDNCR YTYSEWHSFT QPRLGEKVYL 840

CNQDENHKHA QDYVLTYNYE GRGSVAGSVG CCSERQEEDG LEFLDNLEPK FRTLAEACMK gOO R

Seq ID NO.- 618 DNA sequence

Nucleic Acid Accession ft: NM_004g49.1

Coding sequence: 202..2745

1 11 21 31 41 51

I ^' I I I I I

CGCCAAAGGA AAAGCCCCTT GGATGAGAGG CAGGCGCTTC AGAGAAGCTA AGAAAAGCAC 60

CTCTCCGCGC GCCCCACCTC CTCCGCCTCG CGCTCCTCCT GAGCAGCGGG CCCAGACTGC 120

GCTCCGGCCG CGGCCCTCGC CCCGCGGAGC CCTCCTACCC CGGCCCGACG CTCGGCCCGC 180

GACCTGCCCC GAGCCCTCTC CATGGAGGCA GCCCGCCCCT CCGGCTCCTG GAACGGAGCC 240

CTCTGCCGGC TGCTCCTGCT GACCCTCGCG ATCTTAATAT TTGCCAGTGA TGCCTGCAAA 300

AATGTGACAT TACATGTTCC CTCCAAACTA GATGCCGAGA AACTTGTTGG TAGAGTTAAC 360

CTGAAAGAGT GCTTTACAGC TGCAAATCTA ATTCATTCAA GTGATCCTGA CTTCCAAATT 420

TTGGAGGATG GTTCAGTCTA TACAACAAAT ACTATTCTAT TGTCCTCGGA GAAGAGAAGT 480

TTTACCATAT TACTTTCCAA CACTGAGAAC CAAGAAAAGA AGAAAATATT TGTCTTTTTG 540

GAGCATCAAA CAAAGGTCCT AAAGAAAAGA CATACTAAAG AAAAAGTTCT AAGGCGCGCC 600

AAGAGAAGAT GGGCTCCAAT TCCTTGTTCG ATGCTAGAAA ACTCCTTGGG TCCTTTTCCA 660

CTTTTCCTTC AACAGGTTCA ATCTGACACG GCCCAAAACT ATACCATATA CTATTCCATA 720

AGAGGTCCTG GAGTTGACCA AGAACCTCGG AATTTATTTT ATGTGGAGAG AGACACTGGA 780

AACTTGTATT GTACTCGTCC TGTAGATCGT GAGCAGTATG AATCTTTTGA GATAATTGCC 840

TTTGCAACAA CTCCAGATGG GTATACTCCA GAACTTCCAC TGCCCCTAAT AATCAAAATA 900

GAGGATGAAA ATGATAACTA CCCAATTTTT ACAGAAGAAA CTTATACTTT TACAATTTTT 960

GAAAATTGCA GAGTGGGCAC TACTGTGGGA CAAGTGTGTG CTACTGACAA AGATGAGCCT 1020

GACACGATGC ACACACGCCT GAAGTACTCC ATCATTGGGC AGGTGCCACC ATCACCCACC 1080

CTATTTTCTA TGCATCCAAC TACAGGCGTG ATCACCACAA CATCATCTCA GCTAGACAGA 1140

GAGTTAATTG ACAAGTACCA GTTGAAAATA AAAGTACAAG ACATGGATGG TCAGTATTTT 1200

GGTCTACAGA CAACTTCAAC TTGTATCATT AACATTGATG ATGTAAATGA CCACTTGCCA 1260

ACATTTACTC GTACTTCTTA TGTGACATCA GTGGAAGAAA ATACAGTTGA TGTGGAAATC 1320

TTACGAGTTA CTGTTGAGGA TAAGGACTTA GTGAATACTG CTAACTGGAG AGCTAATTAT 1380

ACCATTTTAA AGGGCAATGA AAATGGCAAT TTTAAAATTG TAACAGATGC CAAAACCAAT 1440

GAAGGAGTTC TTTGTGTAGT TAAGCCTTTG AATTATGAAG AAAAGCAACA GATGATCTTG 1500

CAAATTGGTG TAGTTAATGA AGCTCCATTT TCCAGAGAGG CTAGTCCAAG ATCAGCCATG 1560

AGCACAGCAA CAGTTACTGT TAATGTAGAA GATCAGGATG AGGGCCCTGA GTGTAACCCT 1620

CCAATACAGA CTGTTCGCAT GAAAGAAAAT GCAGAAGTGG GAACAACAAG CAATGGATAT 1680

AAAGCATATG ACCCAGAAAC AAGAAGTAGC AGTGGCATAA GGTATAAGAA ATTAACTGAT 1740

CCAACAGGGT GGGTCACCAT TGATGAAAAT ACAGGATCAA TCAAAGTTTT CAGAAGCCTG 1800

GATAGAGAGG CAGAGACCAT CAAAAATGGC ATATATAATA TTACAGTCGT TGCATCAGAC 1860

CAAGGAGGGA GAACATGTAC GGGGACACTG GGCATTATAC TTCAAGACGT GAATGATAAC 1920

AGCCCATTCA TACCTAAAAA GACAGTGATC ATCTGCAAAC CCACCATGTC ATCTGCGGAG 1980

ATTGTTGCGG TTGATCCTGA TGAGCCTATC CATGGCCCAC CCTTTGACTT TAGTCTGGAG 2040

AGTTCTACTT CAGAAGTACA GAGAATGTGG AGACTGAAAG CAATTAATGA TACAGCAGCA 2100

CGTCTTTCCT ATCAGAATGA TCCTCCATTT GGCTCATATG TAGTACCTAT AACAGTGAGA 2160

GATAGACTTG GCATGTCTAG TGTCACTTCA TTGGATGTTA CACTGTGTGA CTGCATTACC 2220

GAAAATGACT GCACACATCG TGTAGATCCA AGGATTGGCG GTGGAGGAGT ACAACTTGGA 2280

AAGTGGGCCA TCCTTGCAAT ATTGTTGGGC ATAGCATTGC TCTTTTGCAT CCTGTTTACG 2340

CTGGTCTGTG GGGCTTCTGG GACGTCTAAA CAACCAAAAG TAATTCCTGA TGATTTAGCC 2400

CAGCAGAACC TAATTGTATC AAACACAGAA GCTCCTGGAG ATGACAAAGT GTATTCTGCG 2460

AATGGCTTCA CAACCCAAAC TGTGGGCGCT TCTGCTCAGG GAGTTTGTGG CACCGTGGGA 2520

TCAGGAATCA AAAACGGAGG TCAGGAGACC ATCGAAATGG TGAAAGGAGG ACACCAGACC 2580

TCGGAATCCT GCCGGGGGGC TGGCCACCAT CACACCCTGG ACTCCTGCAG GGGAGGACAC 2640

ACGGAGGTGG ACAACTGCAG ATACACTTAC TCGGAGTGGC ACAGTTTTAC TCAGCCCCGT 2700

CTTGGTGAAG AATCCATTAG AGGACACACT CTGATTAAAA ATTAAACAAT GAAAGAAAGT 2760

GTATCTGTGT AATCAAGATG AAAATCACAA GCATGCCCAA GACTATGTCC TGACATATAA 2820

CTATGAAGGA AGAGGATCGG TGGCTGGGTC TGTAGGTTGT TGCAGTGAAC GACAAGAAGA 2880

AGATGGGCTT GAATTTTTGG ATAATTTGGA GCCCAAATTT AGGACACTAG CAGAAGCATG 2940

CATGAAGAGA TGAGTGTGTT CTAATAAGTC TCTGAAAGCC AGTGGCTTTA TGACTTTTAA 3000

AAAAAATTAC AAACCAAGAA TTTTTTAAAG CAGAAGATGC TATTTGTGGG GGTTTTTCTC 3060

TCATTATTTG GATGGAATCT CTTTGGTCAA ATGCACATTT ACAGAGAGAC ACTATAAACA 3120

AGTACACAAA TTTTTCAATT TTTACATATT TTTAAATTAC TTATCTTCTA TCCAAGGAGG 3180

TCTACAGAGA AATTAAAGTC TGCCTTATTT GTTACATTTG GGTATAATGA CAACAGCCAA 3240

TTTATAGTGC AATAAAATGT AATTAATTCA AGTCCTTATT ATAGACTATT TGAAGCACAA 3300

CCTAATGGAA AATTGTAGAG ACCTTGCTTT AACATTATCT CCAGTTAATT AAGTGTTCAT 3360

GTGGTGCTTG GAAACTGTTG TTTTCCTGAA CATCTAAAGT GTGTAGACTG CATTCTTGCT 3420

ATTATTTTAT TCTTGTAATG TGACCTTTTC ACTGTGCAAA GGGAGATTTC TAGCCAGGCA 3480 TTGACTATTA CAATTTCATT

Seq ID NO: 619 Protein sequence Protein Accession ft: NP_004940.1

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MEAARPSGSW NGALCRLLLL TLAILIFASD ACKNVTLHVP SKLDAEKLVG RVNLKECFTA ANLIHSSDPD FQILEDGSVY TTNTILLSSE KRSFTILLSN TENQEKKKIF VFLEHQTKVL 120

KKRHTKEKVL RRAKRRWAPI PCSMLENSLG PFPLFLQQVQ SDTAQNYTIY YSIRGPGVDQ 180

EPRNLFYVER DTGNLYCTRP VDREQYESFE IIAFATTPDG YTPELPLPLI IKIEDENDNY 240

PIFTEETYTF TIFENCRVGT TVGQVCATDK DEPDTMHTRL KYSIIGQVPP SPTLFSMHPT 300

TGVITTTSSQ LDRELIDKYQ LKIKVQDMDG QYFGLQTTST CIINIDDVND HLPTFTRTSY 360

VTSVEENTVD VEILRVTVED KDLVNTANWR ANYTILKGNE NGNFKIVTDA KTNEGVLCW 420

KPLNYEEKQQ MILQIGWNE APFSREASPR SAMSTATVTV NVEDQDEGPE CNPPIQTVRM 480

KENAEVGTTS NGYKAYDPET RSSSGIRYKK LTDPTGWVTI DENTGSIKVF RSLDREAETI 540

KNGIYNITVL ASDQGGRTCT GTLGIILQDV NDNSPFIPKK TVIICKPTMS SAEIVAVDPD 600

EPIHGPPFDF SLESSTSEVQ RMWRLKAIND TAARLSYQND PPFGSYWPI TVRDRLGMSS 660

VTSLDVTLCD CITENDCTHR VDPRIGGGGV QLGKWAILAI LLGIALLFCI LFTLVCGASG 720

TSKQPKVIPD DLAQQNLIVS NTEAPGDDKV YSANGFTTQT VGASAQGVCG TVGSGIKNGG 780

QETIEMVKGG HQTSESCRGA GHHHTLDSCR GGHTEVDNCR YTYSEWHSFT QPRLGEESIR 840 GHTLIKN

Seq ID NO: 620 DNA sequence

Nucleic Acid Accession ft: NM_032545.1

Coding sequence: 46..718

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AAACTGATCT TCAATGCACT AAGAGAAGGA GACTCTCAAA CCAAAAATGA CCTGGAGGCA 60

CCATGTCAGG CTTCTGTTTA CGGTCAGTTT GGCATTACAG ATCATCAATT TGGGAAACAG 120

CTATCAAAGA GAGAAACATA ACGGCGGTAG AGAGGAAGTC ACCAAGGTTG CCACTCAGAA 180

GCACCGACAG TCACCGCTCA ACTGGACCTC CAGTCATTTC GGAGAGGTGA CTGGGAGCGC 240

CGAGGGCTGG GGGCCGGAGG AGCCGCTCCC CTACTCCCGG GCTTTCGGAG AGGGTGCGTC 300

CGCGCGGCCG CGCTGCTGCA GGAACGGCGG TACCTGCGTG CTGGGCAGCT TCTGCGTGTG 360

CCCGGCCCAC TTCACCGGCC GCTACTGCGA GCATGACCAG AGGGGCAGTG AATGCGGCGC 420

CCTGGAGCAC GGAGCCTGGA CCCTCCGCGC CTGCCACCTC TGCAGGTGCA TCTTCGGGGC 480

CCTGCACTGC CTCCCCCTCC AGACGCCTGA CCGCTGTGAC CCGAAAGACT TCCTGGCCTG 540

CCACGCTCAC GGGCCGAGCG CCGGGGGCGC GCCCAGCCTG CTACTCTTGC TGCCCTGCGC 600

ACTCCTGCAC CGCCTCCTGC GCCCGGATGC GCCCGCGCAC CCTCGGTCCC TGGTCCCTTC 660

CGTCCTCCAG CGGGAGCGGC GCCCCTGCGG AAGGCCGGGA CTTGGGCATC GCCTTTAATT 720

TTCTATGTTG TAAATAATAG ATGTGTTTAG TTTACCGTAA GCTGAAGCAC TGGGTGAATA 780

TTTTTATTGG GTAATAAATA TTTTCATGAA AGCGCCAAAA AAAAAAAAAA AAAAAAAAAA 840 AAAAAA

Seq ID NO: 621 Protein sequence Protein Accession ft: NP_115934.1

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MTWRHHVRLL FTVSLALQII NLGNSYQREK HNGGREEVTK VATQKHRQSP LNWTSSHFGE 60

VTGSAEGWGP EEPLPYSRAF GEGASARPRC CRNGGTCVLG SFCVCPAHFT GRYCEHDQRR 120

SECGALEHGA WTLRACHLCR CIFGALHCLP LQTPDRCDPK DFLASHAHGP SAGGAPSLLL 180 LLPCALLHRL LRPDAPAHPR SLVPSVLQRE RRPCGRPGLG HRL

Seq ID NO: 622 DNA sequence Nucleic Acid Accession ft: FGENESH predicted Coding sequence: 1..390

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ATGAGGTTCA GTGTCTCAGG CATGAGGACC GACTACCCCA GGAGTGTGCT GGCTCCTGCT 60

TATGTGTCAG TCTGTCTCCT CCTCTTGTGT CCAAGGGAAG TCATCGCTCC CGCTGGCTCA 120

GAACCATGGC TGTGCCAGCC GGCACCCAGG TGTGGAGACA AGATCTACAA CCCCTTGGAG 180

CAGTGCTGTT ACAATGACGC CATCGTGTCC CTGAGCGAGA CCCGCCAATG TGGTCCCCCC 240

TGCACCTTCT GGCCCTGCTT TGAGCTCTGC TGTCTTGATT CCTTTGGCCT CACAAACGAT 300

TTTGTTGTGA AGCTGAAGGT TCAGGGTGTG AATTCCCAGT GCCACTCATC TCCCATCTCC 360 AGTAAATGTG AAAGAGGCCG GATATGTTAG

Seq ID NO: 623 Protein sequence Protein Accession ft: FGENESH predicted

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MRFSVSGMRT DYPRSVLAPA YVSVCLLLLC PREVIAPAGS EPWLCQPAPR CGDKIYNPLE 60 QCCYNDAIVS LSETRQCGPP CTFWPCFELC CLDSFGLTND F KLKVQGV NSQCHSSPIS 120 SKCERGRIC

Seq ID NO: 624 DNA sequence Nucleic Acid Accession ft: M18728.1 Coding sequence: 51..1085

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GGAGCTCAAG CTCCTCTACA AAGAGGTGGA CAGAGAAGAC AGCAGAGACC ATGGGACCCC 60

CCTCAGCCCC TCCCTGCAGA TTGCATGTCC CCTGGAAGGA GGTCCTGCTC ACAGCCTCAC 120

TTCTAACCTT CTGGAACCCA CCCACCACTG CCAAGCTCAC TATTGAATCC ACGCCATTCA 180

ATGTCGCAGA GGGGAAGGAG GTTCTTCTAC TCGCCCACAA CCTGCCCCAG AATCGTATTG 240

GTTACAGCTG GTACAAAGGC GAAAGAGTGG ATGGCAACAG TCTAATTGTA GGATATGTAA 300

TAGGAACTCA ACAAGCTACC CCAGGGCCCG CATACAGTGG TCGAGAGACA ATATACCCCA 360

ATGCATCCCT GCTGATCCAG AACGTCACCC AGAATGACAC AGGATTCTAT ACCCTACAAG 420

TCATAAAGTC AGATCTTGTG AATGAAGAAG CAACCGGACA GTTCCATGTA TACCCGGAGC 480

TGCCCAAGCC CTCCATCTCC AGCAACAACT CCAACCCCGT GGAGGACAAG GATGCTGTGG 540

CCTTCACCTG TGAACCTGAG GTTCAGAACA CAACCTACCT GTGGTGGGTA AATGGTCAGA 600

GCCTCCCGGT CAGTCCCAGG CTGCAGCTGT CCAATGGCAA CATGACCCTC ACTCTACTCA 660 GCGTCAAAAG GAACGATGCA GGATCCTATG AATGTGAAAT ACAGAACCCA GCGAGTGCCA 720

ACCGCAGTGA CCCAGTCACC CTGAATGTCC TCTATGGCCC AGATGTCCCC ACCATTTCCC 780

CCTCAAAGGC CAATTACCGT CCAGGGGAAA ATCTGAACCT CTCCTGCCAC GCAGCCTCTA 840

ACCCACCTGC ACAGTACTCT TGGTTTATCA ATGGGACGTT CCAGCAATCC ACACAAGAGC 900

TCTTTATCCC CAACATCACT GTGAATAATA GCGGATCCTA TATGTGCCAA GCCCATAACT 960

CAGCCACTGG CCTCAATAGG ACCACAGTCA CGATGATCAC AGTCTCTGGA AGTGCTCCTG 1020

TCCTCTCAGC TGTGGCCACC GTCGGCATCA CGATTGGAGT GCTGGCCAGG GTGGCTCTGA 1080

TATAGCAGCC CTGGTGTATT TTCGATATTT CAGGAAGACT GGCAGATTGG ACCAGACCCT _.1140

GAATTCTTCT AGCTCCTCCA ATCCCATTTT ATCCCATGGA ACCACTAAAA ACAAGGTCTG 1200

CTCTGCTCCT GAAGCCCTAT ATGCTGGAGA TGGACAACTC AATGAAAATT TAAAGGGAAA 1260

ACCCTCAGGC CTGAGGTGTG TGCCACTCAG AGACTTCACC TAACTAGAGA CAGTCAAACT 1320

GCAAACCATG GTGAGAAATT GACGACTTCA CACTATGGAC AGCTTTTCCC AAGATGTCAA 1380

AACAAGACTC CTCATCATGA TAAGGCTCTT ACCCCCTTTT AATTTCTCCT TGCTTATGCC 1440

TGCCTCTTTC GCTTGGCAGG ATGATGCTGT CATTAGTATT TCACAAGAAG TAGCTTCAGA 1500

GGGTAACTTA ACAGAGTGTC AGATCTATCT TGTCAATCCC AACGTTTTAC ATAAAATAAG 1560

AGATCCTTTA GTGCACCCAG TGACTGACAT TAGCAGCATC TTTAACACAG CCGTGTGTTC 1620

AAATGTACAG TGGTCCTTTT CAGAGTTGGA CTTCTAGACT CACCTGTTCT CACTCCCTGT 1680

TTTAATTCAA CCCAGCCATG CAATGCCAAA TAATAGAATT GCTCCCTACC AGCTGAACAG 1740

GGAGGAGTCT GTGCAGTTTC TGACACTTGT TGTTGAACAT GGCTAAATAC AATGGGTATC 1800

GCTGAGACTA AGTTCTAGAA ATTAACAAAT GTGCTGCTTG GTTAAAATGG CTACACTCAT 1860

CTGACTCATT CTTTATTCTA TTTTAGTTGG TTTGTATCTT GCCTAAGGTG CGTAGTCCAA 1920

CTCTTGGTAT TACCCTCCTA ATAGTCATAC TAGTAGTCAT ACTCCCTGGT GTAGTGTATT 1980

CTCTAAAAGC TTTAAATGTC TGCATGCAGC CAGCCATCAA ATAGTGAATG GTCTCTCTTT 2040

GGCTGGAATT ACAAAACTCA GAGAAATGTG TCATCAGGAG AACATCATAA CCCATGAAGG 2100

ATAAAAGCCC CAAATGGTGG TAACTGATAA TAGCACTAAT GCTTTAAGAT TTGGTCACAC 2160

TCTCACCTAG GTGAGCGCAT TGAGCCAGTG GTGCTAAATG CTACATACTC CAACTGAAAT 2220

GTTAAGGAAG AAGATAGATC CAATTAAAAA AAATTAAAAC CAATTTAAAA AAAAAAAAGA 2280

ACACAGGAGA TTCCAGTCTA CTTGAGTTAG CATAATACAG AAGTCCCCTC TACTTTAACT 2340

TTTACAAAAA AGTAACCTGA ACTAATCTGA TGTTAACCAA TGTATTTATT TCTGTGGTTC 2400

TGTTTCCTTG TTCCAATTTG ACAAAACCCA CTGTTCTTGT ATTGTATTGC CCAGGGGGAG 2460

CTATCACTGT ACTTGTAGAG TGGTGCTGCT TTAATTCATA AATCACAAAT AAAAGCCAAT 2520 TAGCTCTATA ACT

Seq ID NO: 625 Protein sequence Protein Accession ft: AAA59907.1

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MGPPSAPPCR LHVPWKEVLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE VLLLAHNLPQ 60 NRIGYSWYKG ERVDGNSLIV GYVIGTQQAT PGPAYSGRET IYPNASLLIQ NVTQNDTGFY 120 TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE VQNTTYLWWV 180 NGQSLPVSPR LQLSNGNMTL TLLSVKRNDA GSYECEIQNP ASANRSDPVT LNVLYGPDVP 240 TISPSKANYR PGENLNLSCH AASNPPAQYS WFINGTFQQS TQELFIPNIT VNNSGSYMCQ 300 AHNSATGLNR TTVTMITVSG SAPVLSAVAT VGITIGVLAR VALI

Seq ID NO: 626 DNA sequence Nucleic Acid Accession ft: M18728.1 Coding sequence: 1355..1657

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GGAGCTCAAG CTCCTCTACA AAGAGGTGGA CAGAGAAGAC AGCAGAGACC ATGGGACCCC 60 CCTCAGCCCC TCCCTGCAGA TTGCATGTCC CCTGGAAGGA GGTCCTGCTC ACAGCCTCAC 120 TTCTAACCTT CTGGAACCCA CCCACCACTG CCAAGCTCAC TATTGAATCC ACGCCATTCA 180 ATGTCGCAGA GGGGAAGGAG GTTCTTCTAC TCGCCCACAA CCTGCCCCAG AATCGTATTG 240 GTTACAGCTG GTACAAAGGC GAAAGAGTGG ATGGCAACAG TCTAATTGTA GGATATGTAA 300 TAGGAACTCA ACAAGCTACC CCAGGGCCCG CATACAGTGG TCGAGAGACA ATATACCCCA 360 ATGCATCCCT GCTGATCCAG AACGTCACCC AGAATGACAC AGGATTCTAT ACCCTACAAG 420 TCATAAAGTC AGATCTTGTG AATGAAGAAG CAACCGGACA GTTCCATGTA TACCCGGAGC 480 TGCCCAAGCC CTCCATCTCC AGCAACAACT CCAACCCCGT GGAGGACAAG GATGCTGTGβ 540 CCTTCACCTG TGAACCTGAG GTTCAGAACA CAACCTACCT GTGGTGGGTA AATGGTCAGA 600 GCCTCCCGGT CAGTCCCAGG CTGCAGCTGT CCAATGGCAA CATGACCCTC ACTCTACTCA 660 GCGTCAAAAG GAACGATGCA GGATCCTATG AATGTGAAAT ACAGAACCCA GCGAGTGCCA 720 ACCGCAGTGA CCCAGTCACC CTGAATGTCC TCTATGGCCC AGATGTCCCC ACCATTTCCC 780 CCTCAAAGGC CAATTACCGT CCAGGGGAAA ATCTGAACCT CTCCTGCCAC GCAGCCTCTA 840 ACCCACCTGC ACAGTACTCT TGGTTTATCA ATGGGACGTT CCAGCAATCC ACACAAGAGC 900 TCTTTATCCC CAACATCACT GTGAATAATA GCGGATCCTA TATGTGCCAA GCCCATAACT 960 CAGCCACTGG CCTCAATAGG ACCACAGTCA CGATGATCAC AGTCTCTGGA AGTGCTCCTG 1020 TCCTCTCAGC TGTGGCCACC GTCGGCATCA CGATTGGAGT GCTGGCCAGG GTGGCTCTGA 1080 TATAGCAGCC CTGGTGTATT TTCGATATTT CAGGAAGACT GGCAGATTGG ACCAGACCCT 1140 GAATTCTTCT AGCTCCTCCA ATCCCATTTT ATCCCATGGA ACCACTAAAA ACAAGGTCTG 1200 CTCTGCTCCT GAAGCCCTAT ATGCTGGAGA TGGACAACTC AATGAAAATT TAAAGGGAAA 1260 ACCCTCAGGC CTGAGGTGTG TGCCACTCAG AGACTTCACC TAACTAGAGA CAGTCAAACT 1320 GCAAACCATG GTGAGAAATT GACGACTTCA CACTATGGAC AGCTTTTCCC AAGATGTCAA 1380 AACAAGACTC CTCATCATGA TAAGGCTCTT ACCCCCTTTT AATTTGTCCT TGCTTATGCC 1440 TGCCTCTTTC GCTTGGCAGG ATGATGCTGT CATTAGTATT TCACAAGAAG TAGCTTCAGA 1500 GGGTAACTTA ACAGAGTGTC AGATCTATCT TGTCAATCCC AACGTTTTAC ATAAAATAAG 1560 AGATCCTTTA GTGCACCCAG TGACTGACAT TAGCAGCATC TTTAACACAG CCGTGTGTTC 1620 AAATGTACAG TGGTCCTTTT CAGAGTTGGA CTTCTAGACT CACCTGTTCT CACTCCCTGT 1680 TTTAATTCAA CCCAGCCATG CAATGCCAAA TAATAGAATT GCTCCCTACC AGCTGAACAG 1740 GGAGGAGTCT GTGCAGTTTC TGACACTTGT TGTTGAACAT GGCTAAATAC AATGGGTATC 1800 GCTGAGACTA AGTTGTAGAA ATTAACAAAT GTGCTGCTTG GTTAAAATGG CTACACTCAT 1860 CTGACTCATT CTTTATTCTA TTTTAGTTGG TTTGTATCTT GCCTAAGGTG CGTAGTCCAA ig20 CTCTTGGTAT TACCCTCCTA ATAGTCATAC TAGTAGTCAT ACTCCCTGGT GTAGTGTATT 1980 CTCTAAAAGC TTTAAATGTC TGCATGCAGC CAGCCATCAA ATAGTGAATG GTCTCTCTTT 2040 GGCTGGAATT ACAAAACTCA GAGAAATGTG TCATCAGGAG AACATCATAA CCCATGAAGG 2100 ATAAAAGCCC CAAATGGTGG TAACTGATAA TAGCACTAAT GCTTTAAGAT TTGGTCACAC 2160 TCTCACCTAG GTGAGCGCAT TGAGCCAGTG GTGCTAAATG CTACATACTC CAACTGAAAT 2220

GTTAAGGAAG AAGATAGATC CAATTAAAAA AAATTAAAAC CAATTTAAAA AAAAAAAAGA 2280

ACACAGGAGA TTCCAGTCTA CTTGAGTTAG CATAATACAG AAGTCCCCTC TACTTTAACT 2340

TTTACAAAAA AGTAACCTGA ACTAATCTGA TGTTAACCAA TGTATTTATT TCTGTGGTTC 2400

TGTTTCCTTG TTCCAATTTG ACAAAACCCA CTGTTCTTGT ATTGTATTGC CCAGGGGGAG 2460

CTATCACTGT ACTTGTAGAG TGGTGCTGCT TTAATTCATA AATCACAAAT AAAAGCCAAT 2520 TAGCTCTATA ACT

Seq ID NO: 627 Protein sequence Protein Accession ft: AAA59908.1

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MDSFSQDVKT RLLIMIRLLP PFNLSLLMPA SFAWQDDAVI SISQEVASEG NLTECQIYLV 60 NPNVLHKIRD PLVHPVTDIS SIFNTAVCSN VQWSFSELDF

Seq ID NO: 628 DNA sequence Nucleic Acid Accession ft: M18728.1 Coding sequence: 2370..2501

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GGAGCTCAAG CTCCTCTACA AAGAGGTGGA CAGAGAAGAC AGCAGAGACC ATGGGACCCC 60

CCTCAGCCCC TCCCTGCAGA TTGCATGTCC CCTGGAAGGA GGTCCTGCTC ACAGCCTCAC 120

TTCTAACCTT CTGGAACCCA CCCACCACTG CCAAGCTCAC TATTGAATCC ACGCCATTCA 180

ATGTCGCAGA GGGGAAGGAG GTTCTTCTAC TCGCCCACAA CCTGCCCCAG AATCGTATTG 240

GTTACAGCTG GTACAAAGGC GAAAGAGTGG ATGGCAACAG TCTAATTGTA GGATATGTAA 300

TAGGAACTCA ACAAGCTACC CCAGGGCCCG CATACAGTGG TCGAGAGACA ATATACCCCA 360

ATGCATCCCT GCTGATCCAG AACGTCACCC AGAATGACAC AGGATTCTAT ACCCTACAAG 420

TCATAAAGTC AGATCTTGTG AATGAAGAAG CAACCGGACA GTTCCATGTA TACCCGGAGC 480

TGCCCAAGCC CTCCATCTCC AGCAACAACT CCAACCCCGT GGAGGACAAG GATGCTGTGG 540

CCTTCACCTG TGAACCTGAG GTTCAGAACA CAACCTACCT GTGGTGGGTA AATGGTCAGA 600

GCCTCCCGGT CACTCCCAGG CTGCAGCTGT CCAATGGCAA CATGACCCTC ACTCTACTCA 660

GCGTCAAAAG GAACGATGCA GGATCCTATG AATGTGAAAT ACAGAACCCA GCGAGTGCCA 720

ACCGCAGTGA CCCAGTCACC CTGAATGTCC TCTATGGCCC AGATGTCCCC ACCATTTCCC 780

CCTCAAAGGC CAATTACCGT CCAGGGGAAA ATCTGAACCT CTCCTGCCAC GCAGCCTCTA 840

ACCCACCTGC ACAGTACTCT TGGTTTATCA ATGGGACGTT CCAGCAATCC ACACAAGAGC 900

TCTTTATCCC CAACATCACT GTGAATAATA GCGGATCCTA TATGTGCCAA GCCCATAACT 960

CAGCCACTGG CCTCAATAGG ACCACAGTCA CGATGATCAC AGTCTCTGGA AGTGCTCCTG 1020

TCCTCTCAGC TGTGGCCACC GTCGGCATCA CGATTGGAGT GCTGGCCAGG GTGGCTCTGA 1080

TATAGCAGCC CTGGTGTATT TTCGATATTT CAGGAAGACT GGCAGATTGG ACCAGACCCT 1140

GAATTCTTCT AGCTCCTCCA ATCCCATTTT ATCCCATGGA ACCACTAAAA ACAAGGTCTG 1200

CTCTGCTCCT GAAGCCCTAT ATGCTGGAGA TGGACAACTC AATGAAAATT TAAAGGGAAA 1260

ACCCTCAGGC CTGAGGTGTG TGCCACTCAG AGACTTCACC TAACTAGAGA CAGTCAAACT 1320

GCAAACCATG GTGAGAAATT GACGACTTCA CACTATGGAC AGCTTTTCCC AAGATGTCAA 1380

AACAAGACTC CTCATCATGA TAAGGCTCTT ACCCCCTTTT AATTTGTCCT TGCTTATGCC 1440

TGCCTCTTTC GCTTGGCAGG ATGATGCTGT CATTAGTATT TCACAAGAAG TAGCTTCAGA 1500

GGGTAACTTA ACAGAGTGTC AGATCTATCT TGTCAATCCC AACGTTTTAC ATAAAATAAG 1560

AGATCCTTTA GTGCACCCAG TGACTGACAT TAGCAGCATC TTTAACACAG CCGTGTGTTC 1620

AAATGTACAG TGGTCCTTTT CAGAGTTGGA CTTCTAGACT CACCTGTTCT CACTCCCTGT 1680

TTTAATTCAA CCCAGCCATG CAATGCCAAA TAATAGAATT GCTCCCTACC AGCTGAACAG 1740

GGAGGAGTCT GTGCAGTTTC TGACACTTGT TGTTGAACAT GGCTAAATAC AATGGGTATC 1800

GCTGAGACTA AGTTGTAGAA ATTAACAAAT GTGCTGCTTG GTTAAAATGG CTACACTCAT 1860

CTGACTCATT CTTTATTCTA TTTTAGTTGG TTTGTATCTT GCCTAAGGTG CGTAGTCCAA 1920

CTCTTGGTAT TACCCTCCTA ATAGTCATAC TAGTAGTCAT ACTCCCTGGT GTAGTGTATT 1980

CTCTAAAAGC TTTAAATGTC TGCATGCAGC CAGCCATCAA ATAGTGAATG GTCTCTCTTT 2040

GGCTGGAATT ACAAAACTCA GAGAAATGTG TCATCAGGAG AACATCATAA CCCATGAAGG 2100

ATAAAAGCCC CAAATGGTGG TAACTGATAA TAGCACTAAT GCTTTAAGAT TTGGTCACAC 2160

TCTCACCTAG GTGAGCGCAT TGAGCCAGTG GTGCTAAATG CTACATACTC CAACTGAAAT 2220

GTTAAGGAAG AAGATAGATC CAATTAAAAA AAATTAAAAC CAATTTAAAA AAAAAAAAGA 2280

ACACAGGAGA TTCCAGTCTA CTTGAGTTAG CATAATACAG AAGTCCCCTC TACTTTAACT 2340

TTTACAAAAA AGTAACCTGA ACTAATCTGA TGTTAACCAA TGTATTTATT TCTGTGGTTC 2400

TGTTTCCTTG TTCCAATTTG ACAAAACCCA CTGTTCTTGT ATTGTATTGC CCAGGGGGAG 2460

CTATCACTGT ACTTGTAGAG TGGTGCTGCT TTAATTCATA AATCACAAAT AAAAGCCAAT 2520 TAGCTCTATA ACT

Seq ID NO: 629 Protein sequence Protein Accession ft: AAA59909.1

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MLTNVFISW LFPCSNLTKP TVLVLYCPGG AITVLVEWCC FNS Seq ID NO: 630 DNA sequence

Nucleic Acid Accession ft: NM_016639.1 Coding sequence: 40..429

11 21 31 51

GCGGCGGGCG CAGACAGGGG CGGGCGCAGG ACGTGCACTA TGGCTCGGGG CTCGCTGCGC 60

CGGTTGCTGC GGCTCCTCGT GCTGGGGCTC TGGCTGGCGT TGCTGCGCTC CGTGGCCGGG 120

GAGCAAGCGC CAGGCACCGC CCCCTGCTCC CGCGGCAGCT CCTGGAGCGC GGACCTGGAC 180

AAGTGCATGG ACTGCGCGTC TTGCAGGGCG CGACCGCACA GCGACTTCTG CCTGGGCTGC 240 GCTGCAGCAC CTCCTGCCCC CTTCCGGCTG CTTTGGCCCA TCCTTGGGGG CGCTCTGAGC 300

CTGACCTTCG TGCTGGGGCT GCTTTCTGGC TTTTTGGTCT GGAGACGATG CCGCAGGAGA 360

GAGAAGTTCA CCACCCCCAT AGAGGAGACC GGCGGAGAGG GCTGCCCAGC TGTGGCGCTG 420 ATCCAGTGAC AATGTGCCCC CTGCCAGCCG GGGCTCGCCC ACTCATCATT CATTCATCCA 480

TTCTAGAGCC AGTCTCTGCC TCCCAGACGC GGCGGGAGCC AAGCTCCTCC AACCACAAGG 540

GGGGTGGGGG GCGGTGAATC ACCTCTGAGG CCTGGGCCCA GGGTTCAGGG GAACCTTCCA 600

AGGTGTCTGG TTGCCCTGCC TCTGGCTCCA GAACAGAAAG GGAGCCTCAC GCTGGCTCAC 660

ACAAAACAGC TGACACTGAC TAAGGAACTG CAGCATTTGC ACAGGGGAGG GGGGTGCCCT 720

CCTTCCTTAG GACCTGGGGG CCAGGCTGAC TTGGGGGGCA GACTTGACAC TAGGCCCCAC 780

TCACTCAGAT GTCCTGAAAT TCCACCACGG GGGTCACCCT GGGGGGTTAG GGACCTATTT 840

TTAACACTAG GGGCTGGCCC ACTAGGAGGG CTGGCCCTAA GATACAGACC CCCCCAACTC g00

CCCAAAGCGG GGAGGAGATA TTTATTTTGG GGAGAGTTTG GAGGGGAGGG AGAATTTATT g60 AATAAAAGAA TCTTTAACTT TAAAAAAAAA AAAAAAAA

Seq ID NO: 631 Protein sequence Protein Accession ft: NP_057723.1

1 11 21 31 41 51

I 1 I 1 I I

MARGSLRRLL RLLVLGLWLA LLRSVAGEQA PGTAPCSRGS SWSADLDKCM DCASCRARPH 60

SDFCLGCAAA PPAPFRLLWP ILGGALSLTF VLGLLSGFLV WRRCRRREKF TTPIEETGGE 120 GCPAVALIQ

Seq ID NO: 632 DNA sequence

Nucleic Acid Accession ft: NM_003816.1

Coding sequence: 79..2538

1 11 21 31 41 51

C IGGCAGGGTT GIGAAAATGAT GIGAAGAGGCG GIAGGTGGAGG CIGACCGAGTG CITGAGAGGAA 60

CCTGCGGAAT CGGCCGAGAT GGGGTCTGGC GCGCGCTTTC CCTCGGGGAC CCTTCGTGTC 120

CGGTGGTTGC TGTTGCTTGG CCTGGTGGGC CCAGTCCTCG GTGCGGCGCG GCCAGGCTTT 180

CAACAGACCT CACATCTTTC TTCTTATGAA ATTATAACTC CTTGGAGATT AACTAGAGAA 240

AGAAGAGAAG CCCCTAGGCC CTATTCAAAA CAAGTATCTT ATGTTATTCA GGCTGAAGGA 300

AAAGAGCATA TTATTCACTT GGAAAGGAAC AAAGACCTTT TGCCTGAAGA TTTTGTGGTT 360

TATACTTACA ACAAGGAAGG GACTTTAATC ACTGACCATC CCAATATACA GAATCATTGT 420

CATTATCGGG GCTATGTGGA GGGAGTTCAT AATTCATCCA TTGCTCTTAG CGACTGTTTT 480

GGACTCAGAG GATTGCTGCA TTTAGAGAAT GCGAGTTATG GGATTGAACC CCTGCAGAAC 540

AGCTCTCATT TTGAGCACAT CATTTATCGA ATGGATGATG TCTACAAAGA GCCTCTGAAA 600

TGTGGAGTTT CCAACAAGGA TATAGAGAAA GAAACTGCAA AGGATGAAGA GGAAGAGCCT 660

CCCAGCATGA CTCAGCTACT TCGAAGAAGA AGAGCTGTCT TGCCACAGAC CCGGTATGTG 720

GAGCTGTTCA TTGTCGTAGA CAAGGAAAGG TATGACATGA TGGGAAGAAA TCAGACTGCT 780

GTGAGAGAAG AGATGATTCT CCTGGCAAAC TACTTGGATA GTATGTATAT TATGTTAAAT 840

ATTCGAATTG TGCTAGTTGG ACTGGAGATT TGGACCAATG GAAACCTGAT CAACATAGTT 900

GGGGGTGCTG GTGATGTGCT GGGGAACTTC GTGCAGTGGC GGGAAAAGTT TCTTATCACA 960

CGTCGGAGAC ATGACAGTGC ACAGCTAGTT CTAAAGAAAG GTTTTGGTGG AACTGCAGGA 1020

ATGGCATTTG TGGGAACAGT GTGTTCAAGG AGCCACGCAG GCGGGATTAA TGTGTTTGGA 1080

CAAATCACTG TGGAGACATT TGCTTCCATT GTTGCTCATG AATTGGGTCA TAATCTTGGA 1140

ATGAATCACG ATGATGGGAG AGATTGTTCC TGTGGAGCAA AGAGCTGCAT CATGAATTCA 1200

GGAGCATCGG GTTCCAGAAA CTTTAGCAGT TGCAGTGCAG AGGACTTTGA GAAGTTAACT 1260

TTAAATAAAG GAGGAAACTG CCTTCTTAAT ATTCCAAAGC CTGATGAAGC CTATAGTGCT 1320

CCCTCCTGTG GTAATAAGTT GGTGGACGCT GGGGAAGAGT GTGACTGTGG TACTCCAAAG 1380

GAATGTGAAT TGGACCCTTG CTGCGAAGGA AGTACCTGTA AGCTTAAATC ATTTGCTGAG 1440

TGTGCATATG GTGACTGTTG TAAAGACTGT CGGTTCCTTC CAGGAGGTAC TTTATGCCGA 1500

GGAAAAACCA GTGAGTGTGA TGTTCCAGAG TACTGCAATG GTTCTTCTCA GTTCTGTCAG 1560

CCAGATGTTT TTATTCAGAA TGGATATCCT TGCCAGAATA ACAAAGCCTA TTGCTACAAC 1620

GGCATGTGCC AGTATTATGA TGCTCAATGT CAAGTCATCT TTGGCTCAAA AGCCAAGGCT 1680

GCCCCCAAAG ATTGTTTCAT TGAAGTGAAT TCTAAAGGTG ACAGATTTGG CAATTGTGGT 1740

TTCTCTGGCA ATGAATACAA GAAGTGTGCC ACTGGGAATG CTTTGTGTGG AAAGCTTCAG 1800

TGTGAGAATG TACAAGAGAT ACCTGTATTT GGAATTGTGC CTGCTATTAT TCAAACGCCT 1860

AGTCGAGGCA CCAAATGTTG GGGTGTGGAT TTCCAGCTAG GATCAGATGT TCCAGATCCT 1920

GGGATGGTTA ACGAAGGCAC AAAATGTGGT GCTGGAAAGA TCTGTAGAAA CTTCCAGTGT 1980

GTAGATGCTT CTGTTCTGAA TTATGACTGT GATGTTCAGA AAAAGTGTCA TGGACATGGG 2040

GTATGTAATA GCAATAAGAA TTGTCACTGT 'GAAAATGGCT GGGCTCCCCC AAATTGTGAG 2100

ACTAAAGGAT ACGGAGGAAG TGTGGACAGT GGACCTACAT ACAATGAAAT GAATACTGCA 2160

TTGAGGGACG GACTTCTGGT CTTCTTCTTC CTAATTGTTC CCCTTATTGT CTGTGCTATT 2220

TTTATCTTCA TCAAGAGGGA TCAACTGTGG AGAAGCTACT TCAGAAAGAA GAGATCACAA 2280

ACATATGAGT CAGATGGCAA AAATCAAGCA AACCCTTCTA GACAGCCGGG GAGTGTTCCT 2340

CGACATGTTT CTCCAGTGAC ACCTCCCAGA GAAGTTCCTA TATATGCAAA CAGATTTGCA 2400

GTACCAACCT ATGCAGCCAA GCAACCTCAG CAGTTCCCAT CAAGGCCACC TCCACCACAA 2460

CCGAAAGTAT CATCTCAGGG AAACTTAATT CCTGCCCGTC CTGCTCCTGC ACCTCCTTTA 2520

TATAGTTCCC TCACTTGATT TTTTTAACCT TCTTTTTGCA AATGTCTTCA GGGAACTGAG 2580

CTAATACTTT TTTTTTTTCT TGATGTTTTC TTGAAAAGCC TTTCTGTTGC AACTATGAAT 2640

GAAAACAAAA CACCACAAAA CAGACTTCAC TAACACAGAA AAACAGAAAC TGAGTGTGAG 2700

AGTTGTGAAA TACAAGGAAA TGCAGTAAAG CCAGGGAATT TACAATAACA TTTCCGTTTC 2760

CATCATTGAA TAAGTCTTAT TCAGTCATCG GTGAGGTTAA TGCACTAATC ATGGATTTTT 2820

TGAACATGTT ATTGCAGTGA TTCTCAAATT AACTGTATTG GTGTAAGATT TTTGTCATTA 2880

AGTGTTTAAG TGTTATTCTG AATTTTCTAC CTTAGTTATC ATTAATGTAG TTCCTCATTG 2940

AACATGTGAT AATCTAATAC CTGTGAAAAC TGACTAATCA GCTGCCAATA ATATCTAATA 3000

TTTTTCATCA TGCACGAATT AATAATCATC ATACTCTAGA ATCTTGTCTG TCACTCACTA 3060

CATGAATAAG CAAATATTGT CTTCAAAAGA ATGCACAAGA ACCACAATTA AGATGTCATA 3120

TTATTTTGAA AGTACAAAAT ATACTAAAAG AGTGTGTGTG TATTCACGCA GTTACTCGCT 3180

TCCATTTTTA TGACCTTTCA ACTATAGGTA ATAACTCTTA GAGAAATTAA TTTAATATTA 3240

GAATTTCTAT TATGAATCAT GTGAAAGCAT GACATTCGTT CACAATAGCA CTATTTTAAA 3300

TAAATTATAA GCTTTAAGGT ACGAAGTATT TAATAGATCT AATCAAATAT GTTGATTCAT 3360

GGCTATAATA AAGCAGGAGC AATTATAAAA TCTTCAATCA ATTGAACTTT TACAAAACCA 3420

CTTGAGAATT TCATGAGCAC TTTAAAATCT GAACTTTCAA AGCTTGCTAT TAAATCATTT 3480

AGAATGTTTA CATTTACTAA GGTGTGCTGG GTCATGTAAA ATATTAGACA CTAATATTTT 3540

CATAGAAATT AGGCTGGAGA AAGAAGGAAG AAATGGTTTT CTTAAATACC TACAAAAAAG 3600

TTACTGTGGT ATCTATGAGT TATCATCTTA GCTGTGTTAA AAATGAATTT TTACTATGGC 3660 AGATATGGTA TGGATCGTAA AATTTTAAGC ACTAAAAATT TTTTCATAAC CTTTCATAAT 3720

AAAGTTTAAT AATAGGTTTA TTAACTGAAT TTCATTAGTT TTTTAAAAGT GTTTTTGGTT 3780

TGTGTATATA TACATATACA AATACAACAT TTACAATAAA TAAAATACTT GAAATTCTCA 3840 AAAAAAAAAA AAAAAAAAAA AAAAA

Seq ID NO: 633 Protein sequence Protein Accession ft: NP 003807.1

11 21 31 41 51

I I I I I

MGSGARFPSG TLRVRWLLLL GLVGPVLGAA RPGFQQTSHL SSYEIITPWR LTRERREAPR 60 PYSKQVSYVI QAEGKEHIIH LERNKDLLPE DFWYTYNKE GTLITDHPNI QNHCHYRGYV 120 EGVHNSSIAL SDCFGLRGLL HLENASYGIE PLQNSSHFEH IIYRMDDVYK EPLKCGVSNK 180 DIEKETAKDE EEEPPSMTQL LRRRRAVLPQ TRYVELFIW DKERYDMMGR NQTAVREEMI 240 LLANYLDSMY IMLNIRIVLV GLEIWTNGNL INIVGGAGDV LGNFVQWREK FLITRRRHDS 300 AQLVLKKGFG GTAGMAFVGT VCSRSHAGGI NVFGQITVET FASIVAHELG HNLGMNHDDG 360 RDCSCGAKSC IMNSGASGSR NFSSCSAEDF EKLTLNKGGN CLLNIPKPDE AYSAPSCGNK 420 LVDAGEECDC GTPKECELDP CCEGSTCKLK SFAECAYGDC CKDCRFLPGG TLCRGKTSEC 480 DVPEYCNGSS QFCQPDVFIQ NGYPCQNNKA YCYNGMCQYY DAQCQVIFGS KAKAAPKDCF 540 IEVNSKGDRF GNCGFSGNEY KKCATGNALC GKLQCENVQE IPVFGIVPAI IQTPSRGTKC 600 WGVDFQLGSD VPDPGMVNEG TKCGAGKICR NFQCVDASVL NYDCDVQKKC HGHGVCNSNK 660 NCHCENGWAP PNCETKGYGG SVDSGPTYNE MNTALRDGLL VFFFLIVPLI VCAIFIFIKR 720 DQLWRSYFRK KRSQTYESDG KNQANPSRQP GSVPRHVSPV TPPREVPIYA NRFAVPTYAA 780 KQPQQFPSRP PPPQPKVSSQ GNLIPARPAP APPLYSSLT

Seq ID NO: 634 DNA sequence

Nucleic Acid Accession ft: NM_002091.1

Coding sequence: 56..503

11 21 31 41 51

AGTCTCTGCT CTTGCCAGCC TCTCCGGCGC GCTCCAAGGG CTTCCCGTCG GGACCATGCG 60 CGGCAGTGAG CTCCCGCTGG TCCTGCTGGC GCTGGTCCTC TGCCTAGCGC CCCGGGGGCG 120 AGCGGTCCCG CTGCCTGCGG GCGGAGGGAC CGTGCTGACC AAGATGTACC CGCGCGGCAA 180 CCACTGGGCG GTGGGGCACT TAATGGGGAA AAAGAGCACA GGGGAGTCTT CTTCTGTTTC 240 TGAGAGAGGG AGCCTGAAGC AGCAGCTGAG AGAGTACATC AGGTGGGAAG AAGCTGCAAG 300 GAATTTGCTG GGTCTCATAG AAGCAAAGGA GAACAGAAAC CACCAGCCAC CTCAACCCAA 360 GGCCTTGGGC AATCAGCAGC CTTCGTGGGA TTCAGAGGAT AGCAGCAACT TCAAAGATGT 420 AGGTTCAAAA GGCAAAGTTG GTAGACTCTC TGCTCCAGGT TCTCAACGTG AAGGAAGGAA 480 CCCCCAGCTG AACCAGCAAT GATAATGATG GCCTCTCTCA AAAGAGAAAA ACAAAACCCC 540 TAAGAGACTG AGTTCTGCAA GCATCAGTTC TACCGATCAT CAACAAGATT TCCTTGTGCA 600 AAATATTTGA CTATTCTGTA TCTTTCATCC TTGACTAAAT TCGTGATTTT CAAGCAGCAT 660 CTTCTGGTTT AAACTTGTTT GCTGTGAACA ATTGTCGAAA AGAGTCTTCC AATTAATGCT 720 TTTTTATATC TAGGCTACCT GTTGGTTAGA TTCAAGGCCC CGAGCTGTTA CCATTCACAA 780 TAAAAGCTTA AACACAT

Seq ID NO: 635 Protein sequence Protein Accession ft: NP 002082.1

11 21 31 41 51

MRGSELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS 60 VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK 120 DVGSKGKVGR LSAPGSQREG RNPQLNQQ

Seq ID NO: 636 DNA sequence

Nucleic Acid Accession ft: NM_016522.1

Coding sequence: 265..1299

11 21 31 41 51

GCGGAAGCAG CGAGGAGGGA GCCCCCTTTG GCCGTCCTCC GTGGAACCGG TTTTCCGAGG 60 CTGGCAAAAG CCGAGGCTGG ATTTGGGGGA GGAATATTAG ACTCGGAGGA GTCTGCGCGC 120 TTTTCTCCTC CCCGCGCCTC CCGGTCGCCG CGGGTTCACC GCTCAGTCCC CGCGCTCGCT 180 CCGCACCCCA CCCACTTCCT GTGCTCGCCC GGGGGGCGTG TGCCGTGCGG CTGCCGGAGT 240 TCGGGGAAGT TGTGGCTGTC GAGAATGGGG GTCTGTGGGT ACCTGTTCCT GCCCTGGAAG 300 TGCCTCGTGG TCGTGTCTCT CAGGCTGCTG TTCCTTGTAC CCACAGGAGT GCCCGTGCGC 360 AGCGGAGATG CCACCTTCCC CAAAGCTATG GACAACGTGA CGGTCCGGCA GGGGGAGAGC 420 GCCACCCTCA GGTGCACTAT TGACAACCGG GTCACCCGGG TGGCCTGGCT AAACCGCAGC 480 ACCATCCTCT ATGCTGGGAA TGACAAGTGG TGCCTGGATC CTCGCGTGGT CCTTCTGAGC 540 AACACCCAAA CGCAGTACAG CATCGAGATC CAGAACGTGG ATGTGTATGA CGAGGGCCCT 600 TACACCTGCT CGGTGCAGAC AGACAACCAC CCAAAGACCT CTAGGGTCCA CCTCATTGTG 660 CAAGTATCTC CCAAAATTGT AGAGATTTCT TCAGATATCT CCATTAATGA AGGGAACAAT 720 ATTAGCCTCA CCTGCATAGC AACTGGTAGA CCAGAGCCTA CGGTTACTTG GAGACACATC 780 TCTCCCAAAG CGGTTGGCTT TGTGAGTGAA GACGAATACT TGGAAATTCA GGGCATCACC 840 CGGGAACAGT CAGGGGACTA CGAGTGCAGT GCCTCCAATG ACGTGGCCGC GCCCGTGGTA 900 CGGAGAGTAA AGGTCACCGT GAACTATCCA CCATACATTT CAGAAGCCAA GGGTACAGGT 960 GTCCCCGTGG GACAAAAGGG GACACTGCAG TGTGAAGCCT CAGCAGTCCC CTCAGCAGAA 1020 TTCCAGTGGT ACAAGGATGA CAAAAGACTG ATTGAAGGAA AGAAAGGGGT GAAAGTGGAA 1080 AACAGACCTT TCCTCTCAAA ACTCATCTTC TTCAATGTCT CTGAACATGA CTATGGGAAC 1140 TACACTTGCG TGGCCTCCAA CAAGCTGGGC CACACCAATG CCAGCATCAT GCTATTTGGT 1200 CCAGGCGCCG TCAGCGAGGT GAGCAACGGC ACGTCGAGGA GGGCAGGCTG CGTCTGGCTG 1260 CTGCCTCTTC TGGTCTTGCA CCTGCTTCTC AAATTTTGAT GTGAGTGCCA CTTCCCCACC 1320 CGGGAAAGGC TGCCGCCACC ACCACCACCA ACACAACAGC AATGGCAACA CCGACAGCAA 1380 CCAATCAGAT ATATACAAAT GAAATTAGAA GAAACACAGC CTCATGGGAC AGAAATTTGA 1440 GGGAGGGGAA CAAAGAATAC TTTGGGGGGA AAAGAGTTTT AAAAAAGAAA TTGAAAATTG 1500 CCTTGCAGAT ATTTAGGTAC AATGGAGTTT TCTTTTCCCA AACGGGAAGA ACACAGCACA 1560 CCCGGCTTGβ ACCCACTGCA AGCTGCATCG TGCAACCTCT TTGGTGCCAG TGTGGGCAAG 1620

GGCTCAGCCT CTCTGCCCAC AGACTGCCCC CACGTGGAAC ATTCTGGAGC TGGCCATCCC 1680

AAATTCAATC AGTCCATAGA GACGAACAGA ATGAGACCTT CCGGCCCAAG CGTGGCGCTT 1740

CCGGCCCAAG CGTGGCGCTG CGGGCACTTT GGTAGACTGT GCCACCACGG CGTGTGTTGT 1800 GAAACGTGAA ATAAAAAGAG CAAAAAAAAA AAAAAAAAA

Seq ID NO: 637 Protein sequence Protein Accession ft: NP 057606.1

10 11 21 31 41 51

I I I I I I

MGVCGYLFLP WKCLVWSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG ESATLRCTID 60

NRVTRVAWLN RSTILYAGND KWCLDPRWL LSNTQTQYSI EIQNVDVYDE GPYTCSVQTD 120

NHPKTSRVHL IVQVSPKIVE ISSDISINEG NNISLTCIAT GRPEPTVTWR HISPKAVGFV 180

15 SEDEYLEIQG ITREQSGDYE CSASNDVAAP WRRVKVTVN YPPYISEAKG TGVPVGQKGT 240

LQCEASAVPS AEFQWYKDDK RLIEGKKGVK VENRPFLSKL IFFNVSEHDY GNYTCVASNK 300 LGHTNASIML FGPGAVSEVS NGTSRRAGCV WLLPLLVLHL LLKF

Seq ID NO: 638 DNA sequence 20 Nucleic Acid Accession ft: NM_012261.1 Coding sequence: 203..1045

1 11 21 31 41 51

Δr G IATTTGCTCT G ICCAGCAGCT G ITCGGTGCCG C 1GCTCGACAC C 1GAGTCCTAG C ITAGGCGCTC 60

ACAGAATACG CGCTCCCTCC CTCCCCCTTC TCTGTCCCCC GCCTCTCGCT CACCCCGGCC 120

CACTCCAGCG GCGACTTTGA GGGATTCCCT CTCTGGCGGC CTCTGCAGCA GCACAGCCGG 180

CCTCATTCGG GGCACTGCGA GTATGGATCT CCAAGGAAGA GGGGTCCCCA GCATCGACAG 240

ACTTCGAGTT CTCCTGATGT TGTTCCATAC AATGGCTCAA ATCATGGCAG AACAAGAAGT 300

30 GGAAAATCTC TCAGGCCTTT CCACTAACCC TGAAAAAGAT ATATTTGTGG TGCGGGAAAA 360

TGGGACGACG TGTCTCATGG CAGAGTTTGC AGCCAAATTT ATTGTACCTT ATGATGTGTG 420

GGCCAGCAAC TACGTAGATC TGATCACAGA ACAGGCCGAT ATCGCATTGA CCCGGGGAGC 480

TGAGGTGAAG GGCCGCTGTG GCCACAGCCA GTCGGAGCTG CAAGTGTTCT GGGTGGATCG 540

CGCATATGCA CTCAAAATGC TCTTTGTAAA GGAAAGCCAC AACATGTCCA AGGGACCTGA 600

35 GGCGACTTGG AGGCTGAGCA AAGTGCAGTT TGTCTACGAC TCCTCGGAGA AAACCCACTT 660

CAAAGACGCA GTCAGTGCTG GGAAGCACAC AGCCAACTCG CACCACCTCT CTGCCTTGGT 720

CACCCCCGCT GGGAAGTCCT ATGAGTGTCA AGCTCAACAA ACCATTTCAC TGGCCTCTAG 780

TGATCCGCAG AAGACGGTCA CCATGATCCT GTCTGCGGTC CACATCCAAC CTTTTGACAT 840

TATGTCAGAT TTTGTCTTCA GTGAAGAGCA TAAATGCCCA GTGGATGAGC GGGAGCAACT 900

40 GGAAGAAACC TTGCCCCTGA TTTTGGGGCT CATCTTGGGC CTCGTCATCA TGGTAACACT 960

CGCGATTTAC CACGTCCACC ACAAAATGAC TGCCAACCAG GTGCAGATCC CTCGGGACAG 1020

ATCCCAGTAT AAGCACATGG GCTAGAGGCC GTTAGGCAGG CACCCCCTAT TCCTGCTCCC 1080

CCAACTGGAT CAGGTAGAAC AACAAAAGCA CTTTTCCATC TTGTACACGA GATACACCAA 1140

CATAGCTACA ATCAAACAGG CCTGGGTATC TGAGGCTTGC TTGGCTTGTG TCCATGCTTA 1200

45 AACCCACGGA AGGGGGAGAC TCTTTCGGAT TTGTAGGGTG AAATGGCAAT TATTCTCTCC 1260

ATGCTGGGGA GGAGGGGAGG AGGGTCTCAG ACAGCTTTCG TGCTCATGGT GGCTTGGCTT 1320

TGACTCTCCA AAGAGCAATA AATGCCACTT GGAGCTGTAT CTGGCCCCAA AGTTTAGGGA 1380

TTGAAAACAT GCTTCTTTGA GGAGGAAACC CCTTTAGGTT CAGAAGAATA TGGGGTGCTT 1440

TGCTCCCTTG GACACAGCTG GCTTATCCTA TACAGTTGTC AATGCACACA GAATACAACC 1500

50 TCATGCTCCC TGCAGCAAGA CCCCTGAAAG TGATTCATGC TTCTGGCTGG CATTCTGCAT 1560

GTTTAGTGAT TGTCTTGGGA ATGTTTCACT GCTACCCGCA TCCAGCGACT GCAGCACCAG 1620

AAAACGACTA ATGTAACTAT GCAGAGTTGT TTGGACTTCT TCCTGTGCCA GGTCCAAGTC 1680

GGGGGACCTG AAGAATCAAT CTGTGTGAGT CTGTTTTTCA AAATGAAATA AAACACACTA 1740 TTCTCTGGC

55

Seq ID NO: 639 Protein sequence Protein Accession ft: NP 036393.1

1 11 21 31 41 51

60 i i i i i i

MDLQGRGVPS IDRLRVLLML FHTMAQIMAE QEVENLSGLS TNPEKDIFW RENGTTCLMA 60

EFAAKFIVPY DVWASNYVDL ITEQADIALT RGAEVKGRCG HSQSELQVFW VDRAYALKML 120

FVKESHNMSK GPEATWRLSK VQFVYDSSEK THFKDAVSAG KHTANSHHLS ALVTPAGKSY 180

ECQAQQTISL ASSDPQKTVT MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI 240 65 LGLILGLVIM VTLAIYHVHH KMTANQVQIP RDRSQYKHMG

Seq ID NO: 640 DNA sequence

Nucleic Acid Accession ft: NM_002993.1

Coding sequence: 64..408

70

1 11 21 31 41 51

I I I I I I

GGCACGAGCC AGTCTCCGCG CCTCCACCCA GCTCAGGAAC CCGCGAACCC TCTCTTGACC 60

ACTATGAGCC TCCCGTCCAG CCGCGCGGCG CGTGTCCCGG GTCCTTCGGG CTCCTTGTGC 120

75 GCGCTGCTCG CGCTGCTGCT CCTGCTGACG CCGCCGGGGC CCCTCGCCAG CGCTGGTCCT 180

GTCTCTGCTG TGCTGACAGA GCTGCGTTGC ACTTGTTTAC GCGTTACGCT GAGAGTAAAC 240

CCCAAAACGA TTGGTAAACT GCAGGTGTTC CCCGCAGGCC CGCAGTGCTC CAAGGTGGAA 300

GTGGTAGCCT CCCTGAAGAA CGGGAAGCAA GTTTGTCTGG ACCCGGAAGC CCCTTTTCTA 360

AAGAAAGTCA TCCAGAAAAT TTTGGACAGT GGAAACAAGA AAAACTGAGT AACAAAAAAG 420

80 ACCATGCATC ATAAAATTGC CCAGTCTTCA GCGGAGCAGT TTTCTGGAGA TCCCTGGACC 480

CAGTAAGAAT AAGAAGGAAG GGTTGGTTTT TTTCCATTTT CTACATGGAT TCCCTACTTT 540

GAAGAGTGTG GGGGAAAGCC TACGCTTCTC CCTGAAGTTT ACAGCTCAGC TAATGAAGTA 600

CTAATATAGT ATTTCCACTA TTTACTGTTA TTTTACCTGA TAAGTTATTG AACCCTTTGG 660

CAATTGACCA TATTGTGAGC AAAGAATCAC TGGTTATTAG TCTTTCAATG AATATTGAAT 720

85 TGAAGATAAC TATTGTATTT CTATCATACA TTCCTTAAAG TCTTACCGAA AAGGCTGTGG 780

ATTTCGTATG GAAATAATGT TTTATTAGTG TGCTGTTGAG GGAGGTATCC TGTTGTTCTT 840

ACTCACTCTT CTCATAAAAT AGGAAATATT TTAGTTCTGT TTTCTTGGGG AATATGTTAC 900 TCTTTACCCT AGGATGCTAT TTAAGTTGTA CTGTATTAGA ACACTGGGTG TGTCATACCG 960

TTATCTGTGC AGAATATATT TCCTTATTCA GAATTTCTAA AAATTTAAGT TCTGTAAGGG 1020

CTAATATATT CTCTTCCTAT GGTTTTAGAT GTTTGATGTC TTCTTAGTAT GGCATAATGT 1080

CATGATTTAC TCATTAAACT TTGATTTTGT ATGCTATTTT TTCACTATAG GATGACTATA 1140

ATTCTGGTCA CTAAATATAC ACTTTAGATA GATGAAGAAG CCCAAAAACA GATAAATTCC 1200

TGATTGCTAA TTTACATAGA AATGTATTCT CTTGGTTTTT TAAATAAAAG CAAAATTAAC 1260

AATGATCTGT GCTCTGCAAA GTTTTGAAAA TATATTTGAA CAATTTGAAT ATAAATTCAT 1320

CATTTAGTCC TCAAAATATA TACAGCATTG CTAAGATTTT CAGATATCTA TTGTGGATCT 1380

TTTAAAGGTT TTGACCATTT TGTTATGAGG AATTATACAT GTATCACATT CACTATATTA 1440

AAATTGCACT TTTATTTTTT CCTGTGTGTC ATGTTGGTTT TTGGTACTTG TATTGTCATT 1500 TGGAGAAACA ATAAAAGATT TCTAAACCAA AAAAAAAAAA AAAAAAA

Seq ID NO : 641 Protein sequence Protein Accession ft : NP_002984 .1

1 11 21 31 41 51

I I I I I I

MSLPSSRAAR VPGPSGSLCA LLALLLLLTP PGPLASAGPV SAVLTELRCT CLRVTLRVNP 60

KTIGKLQVFP AGPQCSKVEV VASLKNGKQV CLDPEAPFLK KVIQKILDSG NKKN

Seq ID NO : 642 DNA sequence

Nucleic Acid Accession ft : NM_013271 .1

Coding sequence : 27 . .809 '

1 11 21 31 41 51

1 1 I I I I

TCCGGAGCCA GGCTCGCTGG GGCAGCATGG CGGGGTCGCC GCTGCTCTGG GGGCCGCGGG 60

CCGGGGGCGT CGGCCTTTTG GTGCTGCTGC TGCTCGGCCT GTTTCGGCCG CCCCCCGCGC 120

TCTGCGCGCG GCCGGTAAAG GAACCCCGCG GCCTAAGCGC AGCGTCTCCG CCCTTGGCTG 180

AGACTGGCGC TCCTCGCCGC TTCCGGCGGT CAGTGCCCCG AGGTGAGGCG GCGGGGGCGG 240

TGCAGGAGCT GGCGCGGGCG CTGGCGCATC TGCTGGAGGC CGAACGTCAG GAGCGGGCGC 300

GGGCCGAGGC GCAGGAGGCT GAGGATCAGC AGGCGCGCGT CCTGGCGCAG CTGCTGCGCG 360

TCTGGGGCGC CCCCCGCAAC TCTGATCCGG CTCTGGGCCT GGACGACGAC CCCGACGCGC 420

CTGCAGCGCA GCTCGCTCGC GCTCTGCTCC GCGCCCGCCT TGACCCTGCC GCCCTAGCAG 480

CCCAGCTTGT CCCCGCGCCC GTCCCCGCCG CGGCGCTCCG ACCCCGGCCC CCGGTCTACG 540

ACGACGGCCC CGCGGGCCCG GATGCTGAGG AGGCAGGCGA CGAGACACCC GACGTGGACC 600

CCGAGCTGTT GAGGTACTTG CTGGGACGGA TTCTTGCGGG AAGCGCGGAC TCCGAGGGGG 660

TGGCAGCCCC GCGCCGCCTC CGCCGTGCCG CCGACCACGA TGTGGGCTCT GAGCTGCCCC 720

CTGAGGGCGT GCTGGGGGCG CTGCTGCGTG TGAAACGCCT AGAGACCCCG GCGCCCCAGG 780

TGCCTGCACG CCGCCTCTTG CCACCCTGAG CACTGCCCGG ATCCCGTGCA CCCTGGGACC 840

CAGAAGTGCC CCCGCCATCC CGCCACCAGG ACTTCTCCCC GCCAGCACGT CCAGAGCAAC 900

TTACCCCGGC CAGCCAGCCC TCTCACCCGA GGATCCCTAC CCCCTGGCCC ACAATAACAT 960 GATCTGAGC Seq ID NO: 643 Protein sequence Protein Accession ft: NP 037403.1

1 11 21 31 41 51

I I I I 1 I

MAGSPLLWGP RAGGVGLLVL LLLGLFRPPP ALCARPVKEP RGLSAASPPL AETGAPRRFR 60

RSVPRGEAAG AVQELARALA HLLEAERQER ARAEAQEAED QQARVLAQLL RVWGAPRNSD 120

PALGLDDDPD APAAQLARAL LRARLDPAAL AAQLVPAPVP AAALRPRPPV YDDGPAGPDA 180

EEAGDETPDV DPELLRYLLG RILAGSADSE GVAAPRRLRR AADHDVGSEL PPEGVLGALL 240 RVKRLETPAP QVPARRLLPP

Seq ID NO: 644 DNA sequence Nucleic Acid Accession ft: NM_002214 Coding sequence: 681..2990

1 11 21 31 41 51

CCCAGAGCCG CCTCCCCCTG TTGCTGGCAT CCCGAGCTTC CTCCCTTGCC AGCCAGGACG 60

CTGCCGACTT GTCTTTGCCC GCTGCTCCGC AGACGGGGCT GCAAAGCTGC AACTAATGGT 120

GTTGGCCTCC CTGCCCACCT GTGGAAGCAA CTGCGCTGAT TGATGCGCCA CAGACTTTTT 180 TCCCCTCGAC CTCGCCGGCG TACCCTCCCA CAGATCCAGC ATCACCCAGT GAATGTACAT 240

TAGGGTGGTT TCCCCCCCAG CTTCGGGCTT TGTTTGGGTT TGATTGTGTT TGGCTCTTCG 300

CTAAGCTGAT TTATGCAGCA GAAGCCCCAC CGGCTGGAGA GAAACAAAAG CTCTTTTCTT 360

TGTCCCGGAG CAGGCTGCGG AGCCCTTGCA GAGCCCTCTC TCCAGTCGCC GCCGGGCCCT 420

TGGCCGTCGA AGGAGGTGCT TCTCGCGGAG ACCGCGGGAC CCGCCGTGCC GAGCCGGGAG 480 GGCCGTAGGG GCCCTGAGAT GCCGAGCGGT GCCCGGGCCC GCTTACCTGC ACCGCTTGCT 540

CCGAGCCGCG GGGTCCGCCT GCTAGGCCTG CGGAAAACGT CCTAGCGACA CTCGCCCGCG 600

GGCCCCGAGG TCGCCCGGGA GGCCGAGCCC GCGTCCGGAA GGCAGCCAGG CGGCGGGCGC 660

GGGGCGGGCT GTTTTGCATT ATGTGCGGCT CGGCCCTGGC TTTTTTTACC GCTGCATTTG 720

TCTGCCTGCA AAACGACCGG CGAGGTCCCG CCTCGTTCCT CTGGGCAGCC TGGGTGTTTT 780 CACTTGTTCT TGGACTGGGC CAAGGTGAAG ACAATAGATG TGCATCTTCA AATGCAGCAT 840

CCTGTGCCAG GTGCCTTGCG CTGGGTCCAG AATGTGGATG GTGTGTTCAA GAGGATTTCA 900

TTTCAGGTGG ATCAAGAAGT GAACGTTGTG ATATTGTTTC CAATTTAATA AGCAAAGGCT 960

GCTCAGTTGA TTCAATAGAA TACCCATCTG TGCATGTTAT AATACCCACT GAAAATGAAA 1020

TTAATACCCA GGTGACACCA GGAGAAGTGT CTATCCAGCT GCGTCCAGGA GCCGAAGCTA 1080 ATTTTATGCT GAAAGTTCAT CCTCTGAAGA AATATCCTGT GGATCTTTAT TATCTTGTTG 1140

ATGTCTCAGC ATCAATGCAC AATAATATAG AAAAATTAAA TTCCGTTGGA AACGATTTAT 1200

CTAGAAAAAT GGCATTTTTC TCCCGTGACT TTCGTCTTGG ATTTGGCTCA TACGTTGATA 1260

AAACAGTTTC AGCATACATT AGCATCCACC CCGAAAGGAT TCATAATCAA TGCAGTGACT 1320

ACAATTTAGA CTGCATGCCT CCCCATGGAT ACATCCATGT GCTGTCTTTG ACAGAGAACA 1380 TCACTGAGTT TGAGAAAGCA GTTCATAGAC AGAAGATCTC TGGAAACATA GATACACCAG 1440

AAGGAGGTTT TGACGCCATG CTTCAGGCAG CTGTCTGTGA AAGTCATATC GGATGGCGAA 1500

AAGAGGCTAA AAGATTGCTG CTGGTGATGA CAGATCAGAC GTCTCATCTC GCTCTTGATA 1560 GCAAATTGGC AGGCATAGTG GTGCCCAATG ACGGAAACTG TCATCTGAAA AACAACGTCT 1620

ACGTCAAATC GACAACCATG GAACACCCCT CACTAGGCCA ACTTTCAGAG AAATTAATAG 1680

ACAACAACAT TAATGTCATC TTTGCAGTTC AAGGAAAACA ATTTCATTGG TATAAGGATC 1740

TTCTACCCCT CTTGCCAGGC ACCATTGCTG GTGAAATAGA ATCAAAGGCT GCAAACCTCA 1800

ATAATTTGGT AGTGGAAGCC TATCAGAAGC TCATTTCAGA AGTGAAAGTT CAGGTGGAAA 1860

ACCAGGTACA AGGCATCTAT TTTAACATTA CCGCCATCTG TCCAGATGGG TCCAGAAAGC 1920

CAGGCATGGA AGGATGCAGA AACGTGACGA GCAATGATGA AGTTCTTTTC AATGTAACAG 1980

TTACAATGAA AAAATGTGAT GTCACAGGAG GAAAAAACTA TGCAATAATC AAACCTATTG 2040

GTTTTAATGA AACCGCTAAA ATTCATATAC ACAGAAACTG CAGCTGTCAG TGTGAGGACA 2100

ACAGAGGACC TAAAGGAAAG TGTGTAGATG AAACTTTTCT AGATTCCAAG TGTTTCCAGT 2160

GTGATGAGAA TAAATGTCAT TTTGATGAAG ATCAGTTTTC TTCTGAGAGT TGCAAGTCAC 2220

ACAAGGATCA GCCTGTTTGC AGTGGTCGAG GAGTTTGTGT TTGTGGGAAA TGTTCATGTC 2280

ACAAAATTAA GCTTGGAAAA GTGTATGGAA AATACTGTGA AAAGGATGAC TTTTCTTGTC 2340

CATATCACCA TGGAAATCTG TGTGCTGGGC ATGGAGAGTG TGAAGCAGGC AGATGCCAAT 2400

GCTTCAGTGG CTGGGAAGGT GATCGATGCC AGTGCCCTTC AGCAGCAGCC CAGCACTGTG 2460

TCAATTCAAA GGGCCAAGTG TGCAGTGGAA GAGGCACGTG TGTGTGTGGA AGGTGTGAGT 2520

GCACCGATCC CAGGAGCATC GGCCGCTTCT GTGAACACTG CCCCACCTGT TATACAGCCT 2580

GCAAGGAAAA CTGGAATTGT ATGCAATGCC TTCACCCTCA CAATTTGTCT CAGGCTATAC 2640

TTGATCAGTG CAAAACCTCA TGTGCTCTCA TGGAACAACA GCATTATGTC GACCAAACTT 2700

CAGAATGTTT CTCCAGCCCA AGCTACTTGA GAATATTTTT CATCATTTTC ATAGTTACAT 2760

TCTTGATTGG GTTGCTTAAA GTCCTGATCA TTAGACAGGT GATACTACAA TGGAATAGTA 2820

ATAAAATTAA GTCCTGATCA GATTACAGAG TGTCAGCCTC AAAAAAGGAT AAGTTGATTC 2880

TGCAAAGTGT TTGCACAAGA GCAGTCACCT ACCGACGTGA GAAGCCTGAA GAAATAAAAA 2940

TGGATATCAG CAAATTAAAT GCTCATGAAA CTTTCAGGTG CAACTTCTAA AAAAAGATTT 3000

TTAAACACTT AATGGGAAAC TGGAATTGTT AATAATTGCT CCTAAAGATT ATAATTTTAA 3060

AAGTCACAGG AGGAGACAAA TTGCTCACGG TCATGCCAGT TGCTGGTTGT ACACTCGAAC 3120

GAAGACTGAC AAGTATCCTC ATCATGATGT GACTCACATA GCTGCTGACT TTTTCAGAGA 3180

AAAATGTGTC TTACTACTGT TTGAGACTAG TGTCGTTGTA GCACTTTACT GTAATATATA 3240

ACTTATTTAG ATCAGCATAG AATGTAGATC CTCTGAAGAG CACTGATTAC ACTTTACAGG 3300

TACCTGTTAT CCCTACGCTT CCCAGAGAGA ACAATGCTGT GAGAGAGTTT AGCATTGTGT 3360

CACTACAAGG GTACAGTAAT CCCTGCACTG GACATGTGAG GAAAAAAATA ATCTGGCAAG 3420

TATATTCTAA GGTTGCCAAA CACTTCAACA GTTGGTGGTT GAATAGACAA GAACAGCTAG 3480

ATGAATAAAT GATTCGTGTT TCACTCTTTC AAGAGGTGAA CAGATACAAC CTTAATCTTA 3540

AAAGATTATT GCTTTTTAAA GTGTGTAGTT TTATGCATGT GTGTTTATGG TTTGCTTATT 3600

TTTGCAAGAT GGATACTAAT TCCAGCATTC TCTCCTCTTT GCCTTTATGT TTTGTTTTCT 3660

TTTTTACAGG ATAAGTTTAT GTATGTCACA GATGACTGGA TTAATTAAGT GCTAAGTTAC 3720

TACTGCCATA AAAAACTAAT AATACAATGT CACTTTATCA GAATACTAGT TTTAAAAGCT 3780 GAATGTTAA Seq ID NO: 645 Protein sequence Protein Accession ft: NP 002205

1 11 21 31 41 51

I I I I I I

MCGSALAFFT AAFVCLQNDR RGPASFLWAA WVFSLVLGLG QGEDNRCASS NAASCARCLA 60

LGPECGWCVQ EDFISGGSRS ERCDIVSNLI SKGCSVDSIE YPSVHVIIPT ENEINTQVTP 120

GEVSIQLRPG AEANFMLKVH PLKKYPVDLY YLVDVSASMH NNIEKLNSVG NDLSRKMAFF 180

SRDFRLGFGS YVDKTVSPYI SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFEKA 240

VHRQKISGNI DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV 300

VPNDGNCHLK NNVYVKSTTM EHPΞLGQLSE KLIDNNINVI FAVQGKQFHW YKDLLPLLPG 360

TIAGEIESKA ANLNNLWEA YQKLISEVKV QVENQVQGIY FNITAICPDG SRKPGMEGCR 420

NVTSNDEVLF NVTVTMKKCD VTGGKNYAII KPIGFNETAK IHIHRNCSCQ CEDNRGPKGK 480

CVDETFLDSK CFQCDENKCH FDEDQFSSES CKSHKDQPVC SGRGVCVCGK CSCHKIKLGK 540

VYGKYCEKDD FSCPYHHGNL CAGHGECEAG RCQCFSGWEG DRCQCPSAAA QHCVNSKGQV 600

CSGRGTCVCG RCECTDPRSI GRFCEHCPTC YTACKENWNC MQCLHPHNLS QAILDQCKTS 660

CALMEQQHYV DQTSECFSSP SYLRIFFIIF IVTFLIGLLK VLIIRQVILQ WNSNKIKSSS 720 DYRVSASKKD KLILQSVCTR AVTYRREKPE EIKMDISKLN AHETFRCNF

Seq ID NO: 646 DNA sequence Nucleic Acid Accession ft: NM_003318.1 Coding sequence: 1..2574

1 11 21 31 41 51

I I I I I I

ATGGAATCCG AGGATTTAAG TGGCAGAGAA TTGACAATTG ATTCCATAAT GAACAAAGTG 60

AGAGACATTA AAAATAAGTT TAAAAATGAA GACCTTACTG ATGAACTAAG CTTGAATAAA 120

ATTTCTGCTG ATACTACAGA TAACTCGGGA ACTGTTAACC AAATTATGAT GATGGCAAAC 180

AACCCAGAGG ACTGGTTGAG TTTGTTGCTC AAACTAGAGA AAAACAGTGT TCCGCTAAGT 240

GATGCTCTTT TAAATAAATT GATTGGTCGT TACAGTCAAG CAATTGAAGC GCTTCCCCCA 300

GATAAATATG GCCAAAATGA GAGTTTTGCT AGAATTCAAG TGAGATTTGC TGAATTAAAA 360

GCTATTCAAG AGCCAGATGA TGCACGTGAC TACTTTCAAA TGGCCAGAGC AAACTGCAAG 420

AAATTTGCTT TTGTTCATAT ATCTTTTGCA CAATTTGAAC TGTCACAAGG TAATGTCAAA 480

AAAAGTAAAC AACTTCTTCA AAAAGCTGTA GAACGTGGAG CAGTACCACT AGAAATGCTG 540

GAAATTGCCC TGCGGAATTT AAACCTCCAA AAAAAGCAGC TGCTTTCAGA GGAGGAAAAG 600

AAGAATTTAT CAGCATCTAC GGTATTAACT GCCCAAGAAT CATTTTCCGG TTCACTTGGG 660

CATTTACAGA ATAGGAACAA CAGTTGTGAT TCCAGAGGAC AGACTACTAA AGCCAGGTTT 720

TTATATGGAG AGAACATGCC ACCACAAGAT GCAGAAATAG GTTACCGGAA TTCATTGAGA 780

CAAACTAACA AAACTAAACA GTCATGCCCA TTTGGAAGAG TCCCAGTTAA CCTTCTAAAT 840

AGCCCAGATT GTGATGTGAA GACAGATGAT TCAGTTGTAC CTTGTTTTAT GAAAAGACAA 900

ACCTCTAGAT CAGAATGCCG AGATTTGGTT GTGCCTGGAT CTAAACCAAG TGGAAATGAT 960

TCCTGTGAAT TAAGAAATTT AAAGTCTGTT CAAAATAGTC ATTTCAAGGA ACCTCTGGTG 1020

TCAGATGAAA AGAGTTCTGA ACTTATTATT ACTGATTCAA TAACCCTGAA GAATAAAACG 1080

GAATCAAGTC TTCTAGCTAA ATTAGAAGAA ACTAAAGAGT ATCAAGAACC AGAGGTTCCA 1140

GAGAGTAACC AGAAACAGTG GCAATCTAAG AGAAAGTCAG AGTGTATTAA CCAGAATCCT 1200

GCTGCATCTT CAAATCACTG GCAGATTCCG GAGTTAGCCC GAAAAGTTAA TACAGAGCAG 1260

AAACATACCA CTTTTGAGCA ACCTGTCTTT TCAGTTTCAA AACAGTCACC ACCAATATCA 1320

ACATCTAAAT GGTTTGACCC AAAATCTATT TGTAAGACAC CAAGCAGCAA TACCTTGGAT 1380 GATTACATGA GCTGTTTTAG AACTCCAGTT GTAAAGAATG ACTTTCCACC TGCTTGTCAG 1440

TTGTCAACAC CTTATGGCCA ACCTGCCTGT TTCCAGCAGC AACAGCATGA AATACTTGCC 1500

ACTCCACTTC AAAATTTACA GGTTTTAGCA TCTTCTTCAG CAAATGAATG CATTTCGGTT 1560

AAAGGAAGAA TTTATTCCAT TTTAAAGCAG ATAGGAAGTG GAGGTTCAAG CAAGGTATTT 1620

CAGGTGTTAA ATGAAAAGAA ACAGATATAT GCTATAAAAT ATGTGAACTT AGAAGAAGCA 1680

GATAACCAAA CTCTTGATAG TTACCGGAAC GAAATAGCTT ATTTGAATAA ACTACAACAA 1740

CACAGTGATA AGATCATCCG ACTTTATGAT TATGAAATCA CGGACCAGTA CATCTACATG 1800

GTAATGGAGT GTGGAAATAT TGATCTTAAT AGTTGGCTTA AAAAGAAAAA ATCCATTGAT 1860

CCATGGGAAC GCAAGAGTTA CTGGAAAAAT ATGTTAGAGG CAGTTCACAC AATCCATCAA 1920

CATGGCATTG TTCACAGTGA TCTTAAACCA GCTAACTTTC TGATAGTTGA TGGAATGCTA 1980

AAGCTAATTG ATTTTGGGAT TGCAAACCAA ATGCAACCAG ATACAACAAG TGTTGTTAAA 2040

GATTCTCAGG TTGGCACAGT TAATTATATG CCACCAGAAG CAATCAAAGA TATGTCTTCC 2100

TCCAGAGAGA ATGGGAAATC TAAGTCAAAG ATAAGCCCCA AAAGTGATGT TTGGTCCTTA 2160

GGATGTATTT TGTACTATAT GACTTACGGG AAAACACCAT TTCAGCAGAT AATTAATCAG 2220

ATTTCTAAAT TACATGCCAT AATTGATCCT AATCATGAAA TTGAATTTCC CGATATTCCA 2280

GAGAAAGATC TTCAAGATGT GTTAAAGTGT TGTTTAAAAA GGGACCCAAA ACAGAGGATA 2340

TCCATTCCTG AGCTCCTGGC TCATCCCTAT GTTCAAATTC AAACTCATCC AGTTAACCAA 2400

ATGGCCAAGG GAACCACTGA AGAAATGAAA TATGTTCTGG GCCAACTTGT TGGTCTGAAT 2460

TCTCCTAACT CCATTTTGAA AGCTGCTAAA ACTTTATATG AACACTATAG TGGTGGTGAA 2520 AGTCATAATT CTTCATCCTC CAAGACTTTT GAAAAAAAAA GGGGAAAAAA ATGA

Seq ID NO: 647 Protein sequence Protein Accession ft: NP 003309.1

11 21 31 41 51

I I 1 I 1

MESEDLSGRE LTIDSIMNKV RDIKNKFKNE DLTDELSLNK ISADTTDNSG TVNQIMMMAN 60 NPEDWLSLLL KLEKNSVPLS DALLNKLIGR YSQAIEALPP DKYGQNESFA RIQVRFAELK 120 AIQEPDDARD YFQMARANCK KFAFVHISFA QFELSQGNVK KSKQLLQKAV ERGAVPLEML 180 EIALRNLNLQ KKQLLSEEEK KNLSASTVLT AQESFSGSLG HLQNRNNSCD SRGQTTKARF 240 LYGENMPPQD AEIGYRNSLR QTNKTKQSCP FGRVPVNLLN SPDCDVKTDD SWPCFMKRQ 300 TSRSECRDLV VPGSKPSGND SCELRNLKSV QNSHFKEPLV SDEKSSELII TDSITLKNKT 360 ESSLLAKLEE TKEYQEPEVP ESNQKQWQSK RKSECINQNP AASSNHWQIP ELARKVNTEQ 420 KHTTFEQPVF SVSKQSPPIS TSKWFDPKSI CKTPSSNTLD DYMSCFRTPV VKNDFPPACQ 480 LSTPYGQPAC FQQQQHQILA TPLQNLQVLA SSSANECISV KGRIYSILKQ IGSGGSSKVF 540 QVLNEKKQIY AIKYVNLEEA DNQTLDSYRN EIAYLNKLQQ HSDKIIRLYD YEITDQYIYM 600 VMECGNIDLN SWLKKKKSID PWERKSYWKN MLEAVHTIHQ HGIVHSDLKP ANF IVDGML 660 KLIDFGIANQ MQPDTTSWK DSQVGTVNYM PPEAIKDMSS SRENGKSKSK ISPKSDVWSL 720 GCILYYMTYG KTPFQQIINQ ISKLHAIIDP NHEIEFPDIP EKDLQDVLKC CLKRDPKQRI 780 SIPELLAHPY VQIQTHPVNQ MAKGTTEEMK YVLGQLVGLN SPNSILKAAK TLYEHYSGGE 840 SHNSSSSKTF EKKRGKK

Seq ID NO: 648 DNA sequence Nucleic Acid Accession ft: NM_015507 Coding sequence: 241..1902

11 21 31 41 51

CCGCAGAGGA GCCTCGGCCA GGCTAGCCAG GGCGCCCCCA GCCCCTCCCC AGGCCGCGAG 60 CGCCCCTGCC GCGGTGCCTG GCCTCCCCTC CCAGACTGCA GGGACAGCAC CCGGTAACTG 120 CGAGTGGAGC GGAGGACCCG AGCGGCTGAG GAGAGAGGAG GCGGCGGCTT AGCTGCTACG 180 GGGTCCGGCC GGCGCCCTCC CGAGGGGGGC TCAGGAGGAG GAAGGAGGAC CCGTGCGAGA 240 ATGCCTCTGC CCTGGAGCCT TGCGCTCCCG CTGCTGCTCT CCTGGGTGGC AGGTGGTTTC 300 GGGAACGCGG CCAGTGCAAG GCATCACGGG TTGTTAGCAT CGGCACGTCA GCCTGGGGTC 360 TGTCACTATG GAACTAAACT GGCCTGCTGC TACGGCTGGA GAAGAAACAG CAAGGGAGTC 420 TGTGAAGCTA CATGCGAACC TGGATGTAAG TTTGGTGAGT GCGTGGGACC AAACAAATGC 480 AGATGCTTTC CAGGATACAC CGGGAAAACC TGCAGTCAAG ATGTGAATGA GTGTGGAATG 540 AAACCCCGGC CATGCCAACA CAGATGTGTG AATACACACG GAAGCTACAA GTGCTTTTGC 600 CTCAGTGGCC ACATGCTCAT GCCAGATGCT ACGTGTGTGA ACTCTAGGAC ATGTGCCATG 660 ATAAACTGTC AGTACAGCTG TGAAGACACA GAAGAAGGGC CACAGTGCCT GTGTCCATCC 720 TCAGGACTCC GCCTGGCCCC AAATGGAAGA GACTGTCTAG ATATTGATGA ATGTGCCTCT 780 GGTAAAGTCA TCTGTCCCTA CAATCGAAGA TGTGTGAACA CATTTGGAAG CTACTACTGC 840 AAATGTCACA TTGGTTTCGA ACTGCAATAT ATCAGTGGAC GATATGACTG TATAGATATA 900 AATGAATGTA CTATGGATAβ CCATACGTGC AGCCACCATG CCAATTGCTT CAATACCCAA 960 GGGTCCTTCA AGTGTAAATG CAAGCAGGGA TATAAAGGCA ATGGACTTCG GTGTTCTGCT 1020 ATCCCTGAAA ATTCTGTGAA GGAAGTCCTC AGAGCACCTG GTACCATCAA AGACAGAATC 1080 AAGAAGTTGC TTGCTCACAA AAACAGCATG AAAAAGAAGG CAAAAATTAA AAATGTTACC 1140 CCAGAACCCA CCAGGACTCC TACCCCTAAG GTGAACTTGC AGCCCTTCAA CTATGAAGAG 1200 ATAGTTTCCA GAGGCGGGAA CTCTCATGGA GGTAAAAAAG GGAATGAAGA GAAAATGAAA 1260 GAGGGGCTTG AGGATGAGAA AAGAGAAGAG AAAGCCCTGA AGAATGACAT AGAGGAGCGA 1320 AGCCTGCGAG GAGATGTGTT TTTCCCTAAG GTGAATGAAG CAGGTGAATT CGGCCTGATT 1380 CTGGTCCAAA GGAAAGCGCT AACTTCCAAA CTGGAACATA AAGATTTAAA TATCTCGGTT 1440 GACTGCAGCT TCAATCATGG GATCTGTGAC TGGAAACAGG ATAGAGAAGA TGATTTTGAC 1500 TGGAATCCTG CTGATCGAGA TAATGCTATT GGCTTCTATA TGGCAGTTCC GGCCTTGGCA 1560 GGTCACAAGA AAGACATTGG CCGATTGAAA CTTCTCCTAC CTGACCTGCA ACCCCAAAGC 1620 AACTTCTGTT TGCTCTTTGA TTACCGGCTG GCCGGAGACA AAGTCGGGAA ACTTCGAGTG 1680 TTTGTGAAAA ACAGTAACAA TGCCCTGGCA TGGGAGAAGA CCACGAGTGA GGATGAAAAG 1740 TGGAAGACAG GGAAAATTCA GTTGTATCAA GGAACTGATG CTACCAAAAG CATCATTTTT 1800 GAAGCAGAAC GTGGCAAGGG CAAAACCGGC GAAATCGCAG TGGATGGCGT CTTGCTTGTT 1860 TCAGGCTTAT GTCCAGATAG CCTTTTATCT GTGGATGACT GAATGTTACT ATCTTTATAT 1920 TTGACTTTGT ATGTCAGTTC CCTGGTTTTT TTGATATTGC ATCATAGGAC CTCTGGCATT 1980 TTAGAATTAC TAGCTGAAAA ATTGTAATGT ACCAACAGAA ATATTATTGT AAGATGCCTT 2040 TCTTGTATAA GATATGCCAA TATTTGCTTT AAATATCATA TCACTGTATC TTCTCAGTCA 2100 TTTCTGAATC TTTCCACATT ATATTATAAA ATATGGAAAT GTCAGTTTAT CTCCCCTCCT 2160 CAGTATATCT GATTTGTATA AGTAAGTTGA TGAGCTTCTC TCTACAACAT TTCTAGAAAA 2220 TAGAAAAAAA AGCACAGAGA AATGTTTAAC TGTTTGACTC TTATGATACT TCTTGGAAAC 2280 TATGACATCA AAGATAGACT TTTGCCTAAG TGGCTTAGCT GGGTCTTTCA TAGCCAAACT 2340 TGTATATTTA AATTCTTTGT AATAATAATA TCCAAATCAT CAAAAAAAAA AAAAAAAA

Seq ID NO: 649 Protein sequence Protein Accession ft: NP_056322

1 11 21 31 41 51

I I 1 I I I

MPLPWSLALP LLLSWVAGGF GNAASARHHG LLASARQPGV CHYGTKLACC YGWRRNSKGV 60

CEATCEPGCK FGECVGPNKC RCFPGYTGKT CSQDVNECGM KPRPCQHRCV NTHGSYKCFC 120

LSGHMLMPDA TCVNSRTCAM INCQYSCEDT EEGPQCLCPS SGLRLAPNGR DCLDIDECAS 180

GKVICPYNRR CVNTFGSYYC KCHIGFELQY ISGRYDCIDI NECTMDSHTC SHHANCFNTQ 240

GSFKCKCKQG YKGNGLRCSA IPENSVKEVL RAPGTIKDRI KKLLAHKNSM KKKAKIKNVT 300

PEPTRTPTPK VNLQPFNYEE IVSRGGNSHG GKKGNEEKMK EGLEDEKREE KALKNDIEER 360

SLRGDVFFPK VNEAGEFGLI LVQRKALTSK LEHKDLNISV DCSFNHGICD WKQDREDDFD 420

WNPADRDNAI GFYMAVPALA GHKKDIGRLK LLLPDLQPQS NFCLLFDYRL AGDKVGKLRV 480

FVKNSNNALA WEKTTSEDEK WKTGKIQLYQ GTDATKSIIF EAERGKGKTG EIAVDGVLLV 540 SGLCPDSLLS VDD

Seq ID NO: 650 DNA sequence

Nucleic Acid Accession ft: NM_0O3506.1

Coding sequence: 259.-2379 1 11 21 31 41 51 I I i i i i

GCAGCTCCAG TCCCGGACGC AACCCCGGAG CCGTCTCAGG TCCCTGGGGG GAACGGTGGG 60

TTAGACGGGG ACGGGAAGGG ACAGCGGCCT TCGACCGCCC CCCGAGTAAT TGACCCAGGA 120

CTCATTTTCA GGAAAGCCTG AAAATGAGTA AAATAGTGAA ATGAGGAATT TGAACATTTT 180

ATCTTTGGAT GGGGATCTTC TGAGGATGCA AAGAGTGATT CATCCAAGCC ATGTGGTAAA 240

ATCAGGAATT TGAAGAAAAT GGAGATGTTT ACATTTTTGT TGACGTGTAT TTTTCTACCC 300

CTCCTAAGAG GGCACAGTCT CTTCACCTGT GAACCAATTA CTGTTCCCAG ATGTATGAAA 360

ATGGCCTACA ACATGACGTT TTTCCCTAAT CTGATGGGTC ATTATGACCA GAGTATTGCC 420

GCGGTGGAAA TGGAGCATTT TCTTCCTCTC GCAAATCTGG AATGTTCACC AAACATTGAA 480

ACTTTCCTCT GCAAAGCATT TGTACCAACC TGCATAGAAC AAATTCATGT GGTTCCACCT 540

TGTCGTAAAC TTTGTGAGAA AGTATATTCT GATTGCAAAA AATTAATTGA CACTTTTGGG 600

ATCCGATGGC CTGAGGAGCT TGAATGTGAC AGATTACAAT ACTGTGATGA GACTGTTCCT 660

GTAACTTTTG ATCCACACAC AGAATTTCTT GGTCCTCAGA AGAAAACAGA ACAAGTCCAA 720

AGAGACATTG GATTTTGGTG TCCAAGGCAT CTTAAGACTT CTGGGGGACA AGGATATAAG 780

TTTCTGGGAA TTGACCAGTG TGCGCCTCCA TGCCCCAACA TGTATTTTAA AAGTGATGAG 840

CTAGAGTTTG CAAAAAGTTT TATTGGAACA GTTTCAATAT TTTGTCTTTG TGCAACTCTC 900

TTCACATTCC TTACTTTTTT AATTGATGTT AGAAGATTCA GATACCCAGA GAGACCAATT 960

ATATATTACT CTGTCTGTTA CAGCATTGTA TCTCTTATGT ACTTCATTGG ATTTTTGCTG 1020

GGCGATAGCA CAGCCTGCAA TAAGGCAGAT GAGAAGCTAG AACTTGGTGA CACTGTTGTC 1080

CTAGGCTCTC AAAATAAGGC TTGCACCGTT TTGTTCATGC TTTTGTATTT TTTCACAATG 1140

GCTGGCACTG TGTGGTGGGT GATTCTTACC ATTACTTGGT TCTTAGCTGC AGGAAGAAAA 1200

TGGAGTTGTG AAGCCATCGA GCAAAAAGCA GTGTGGTTTC ATGCTGTTGC ATGGGGAACA 1260

CCAGGTTTCC TGACTGTTAT GCTTCTTGCT CTGAACAAAG TTGAAGGAGA CAACATTAGT 1320

GGAGTTTGCT TTGTTGGCCT TTATGACCTG GATGCTTCTC GCTACTTTGT ACTCTTGCCA 1380

CTGTGCCTTT GTGTGTTTGT TGGGCTCTCT CTTCTTTTAG CTGGCATTAT TTCCTTAAAT 1440

CATGTTCGAC AAGTCATACA ACATGATGGC CGGAACCAAG AAAAACTAAA GAAATTTATG 1500

ATTCGAATTG GAGTCTTCAG CGGCTTGTAT CTTGTGCCAT TAGTGACACT TCTCGGATGT 1560

TACGTCTATG AGCAAGTGAA CAGGATTACC TGGGAGATAA CTTGGGTCTC TGATCATTGT 1620

CGTCAGTACC ATATCCCATG TCCTTATCAG GCAAAAGCAA AAGCTCGACC AGAATTGGCT 1680

TTATTTATGA TAAAATACCT GATGACATTA ATTGTTGGCA TCTCTGCTGT CTTCTGGGTT 1740

GGAAGCAAAA AGACATGCAC AGAATGGGCT GGGTTTTTTA AACGAAATCG CAAGAGAGAT 1800

CCAATCAGTG AAAGTCGAAG AGTACTACAG GAATCATGTG AGTTTTTCTT AAAGCACAAT 1860

TCTAAAGTTA AACACAAAAA GAAGCACTAT AAACCAAGTT CACACAAGCT GAAGGTCATT 1920

TCCAAATCCA TGGGAACCAG CACAGGAGCT ACAGCAAATC ATGGCACTTC TGCAGTAGCA 1980

ATTACTAGCC ATGATTACCT AGGACAAGAA ACTTTGACAG AAATCCAAAC CTCACCAGAA 2040

ACATCAATGA GAGAGGTGAA AGCGGACGGA GCTAGCACCC CCAGGTTAAG AGAACAGGAC 2100

TGTGGTGAAC CTGCCTCGCC AGCAGCATCC ATCTCCAGAC TCTCTGGGGA ACAGGTCGAC 2160

GGGAAGGGCC AGGCAGGCAG TGTATCTGAA AGTGCGCGGA GTGAAGGAAG GATTAGTCCA 2220

AAGAGTGATA TTACTGACAC TGGCCTGGCA CAGAGCAACA ATTTGCAGGT CCCCAGTTCT 2280

TCAGAACCAA GCAGCCTCAA AGGTTCCACA TCTCTGCTTG TTCACCCAGT TTCAGGAGTG 2340

AGAAAAGAGC AGGGAGGTGG TTGTCATTCA GATACTTGAA GAACATTTTC TCTCGTTACT 2400

CAGAAGCAAA TTTGTGTTAC ACTGGAAGTG ACCTATGCAC TGTTTTGTAA GAATCACTGT 2460

TACGTTCTTC TTTTGCACTT AAAGTTGCAT TGCCTACTGT TATACTGGAA AAAATAGAGT 2520

TCAAGAATAA TATGACTCAT TTCACACAAA GGTTAATGAC AACAATATAC CTGAAAACAG 2580

AAATGTGCAG GTTAATAATA TTTTTTTAAT AGTGTGGGAG GACAGAGTTA GAGGAATCTT 2640

CCTTTTCTAT TTATGAAGAT TCTACTCTTG GTAAGAGTAT TTTAAGATGT ACTATGCTAT 2700

TTTACCTTTT TGATATAAAA TCAAGATATT TCTTTGCTGA AGTATTTAAA TCTTATCCTT 2760

GTATCTTTTT ATACATATTT GAAAATAAGC TTATATGTAT TTGAACTTTT TTGAAATCCT 2820

ATTCAAGTAT TTTTATCATG CTATTGTGAT ATTTTAGCAC TTTGGTAGCT TTTACACTGA 2880

ATTTCTAAGA AAATTGTAAA ATAGTCTTCT TTTATACTGT AAAAAAAGAT ATACCAAAAA 2940

GTCTTATAAT AGGAATTTAA CTTTAAAAAC CCACTTATTG ATACCTTACC ATCTAAAATG 3000

TGTGATTTTT ATAGTCTCGT TTTAGGAATT TCACAGATCT AAATTATGTA ACTGAAATAA 3060

GGTGCTTACT CAAAGAGTGT CCACTATTGA TTGTATTATG CTGCTCACTG ATCCTTCTGC 3120

ATATTTAAAA TAAAATGTCC TAAAGGGTTA GTAGACAAAA TGTTAGTCTT TTGTATATTA 3180

GGCCAAGTGC AATTGACTTC CCTTTTTTAA TGTTTCATGA CCACCCATTG ATTGTATTAT 3240

AACCACTTAC AGTTGCTTAT ATTTTTTGTT TTAACTTTTG TTTCTTAACA TTTAGAATAT 3300 TACATTTTGT ATTATACAGT ACCTTTCTCA GACATTTTGT AG

Seq ID NO: 651 Protein sequence Protein Accession ft: NP_003497.1

1 11 21 31 41 51

I I I I I I MEMFTFLLTC IFLPLLRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD QSIAAVEMEH 60

FLPLANLECS PNIETFLCKA FVPTCIEQIH WPPCRKLCE KVYSDCKKLI DTFGIRWPEE 120

LECDRLQYCD ETVPVTFDPH TEFLGPQKKT EQVQRDIGFW CPRHLKTSGG QGYKFLGIDQ 180

CAPPCPNMYF KSDELEFAKS FIGTVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC 240

YSIVSLMYFI GFLLGDSTAC NKADEKLELG DT LGSQNK ACTVLFMLLY FFTMAGTVWW 300

VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGTPGFLTV MLLALNKVEG DNISGVCFVG 360

LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 420

SGLYLVPLVT LLGCYVYEQV NRITWEITWV SDHCRQYHIP CPYQAKAKAR PELALFMIKY 480

LMTLIVGISA VFWVGSKKTC TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK 540

KKHYKPSSHK LKVISKSMGT STGATANHGT SAVAITSHDY LGQETLTEIQ TSPETSMREV 600

KADGASTPRL REQDCGEPAS PAASISRLSG EQVDGKGQAG SVSESARSEG RISPKSDITD 660 TGLAQSNNLQ VPSSSEPSSL KGSTSLLVHP VSGVRKEQGG GCHSDT

Seq ID NO: 652 DNA sequence

Nucleic Acid Accession ft: NM_014791.1

Coding sequence: 171..2126

1 11 21 31 41 51

I I I I I I

TTGGCGGGCG GAAGCGGCCA CAACCCGGCG ATCGAAAAGA TTCTTAGGAA CGCCGTACCA 60

GCCGCGTCTC TCAGGACAGC AGGCCCCTGT CCTTCTGTCG GGCGCCGCTC AGCCGTGCCC 120

TCCGCCCCTC AGGTTCTTTT TCTAATTCCA AATAAACTTG CAAGAGGACT ATGAAAGATT 180

ATGATGAACT TCTCAAATAT TATGAATTAC ATGAAACTAT TGGGACAGGT GGCTTTGCAA 240

AGGTCAAACT TGCCTGCCAT ATCCTTACTG GAGAGATGGT AGCTATAAAA ATCATGGATA 300

AAAACACACT AGGGAGTGAT TTGCCCCGGA TCAAAACGGA GATTGAGGCC TTGAAGAACC 360

TGAGACATCA GCATATATGT CAACTCTACC ATGTGCTAGA GACAGCCAAC AAAATATTCA 420

TGGTTCTTGA GTACTGCCCT GGAGGAGAGC TGTTTGACTA TATAATTTCC CAGGATCGCC 480

TGTCAGAAGA GGAGACCCGG GTTGTCTTCC GTCAGATAGT ATCTGCTGTT GCTTATGTGC 540

ACAGCCAGGG CTATGCTCAC AGGGACCTCA AGCCAGAAAA TTTGCTGTTT GATGAATATC 600

ATAAATTAAA GCTGATTGAC TTTGGTCTCT GTGCAAAACC CAAGGGTAAC AAGGATTACC 660

ATCTACAGAC ATGCTGTGGG AGTCTGGCTT ATGCAGCACC TGAGTTAATA CAAGGCAAAT 720

CATATCTTGG ATCAGAGGCA GATGTTTGGA GCATGGGCAT ACTGTTATAT GTTCTTATGT 780

GTGGATTTCT ACCATTTGAT GATGATAATG TAATGGCTTT ATACAAGAAG ATTATGAGAG 840

GAAAATATGA TGTTCCCAAG TGGCTCTCTC CCAGTAGCAT TCTGCTTCTT CAACAAATGC 900

TGCAGGTGGA CCCAAAGAAA CGGATTTCTA TGAAAAATCT ATTGAACCAT CCCTGGATCA 960

TGCAAGATTA CAACTATCCT GTTGAGTGGC AAAGCAAGAA TCCTTTTATT CACCTCGATG 1020

ATGATTGCGT AACAGAACTT TCTGTACATC ACAGAAACAA CAGGCAAACA ATGGAGGATT 1080

TAATTTCACT GTGGCAGTAT GATCACCTCA CGGCTACCTA TCTTCTGCTT CTAGCCAAGA 1140

AGGCTCGGGG AAAACCAGTT CGTTTAAGGC TTTCTTCTTT CTCCTGTGGA CAAGCCAGTG 1200

CTACCCCATT CACAGACATC AAGTCAAATA ATTGGAGTCT GGAAGATGTG ACCGCAAGTG 1260

ATAAAAATTA TGTGGCGGGA TTAATAGACT ATGATTGGTG TGAAGATGAT TTATCAACAG 1320

GTGCTGCTAC TCCCCGAACA TCACAGTTTA CCAAGTACTG GACAGAATCA AATGGGGTGG 1380

AATCTAAATC ATTAACTCCA GCCTTATGCA GAACACCTGC AAATAAATTA AAGAACAAAG 1440

AAAATGTATA TACTCCTAAG TCTGCTGTAA AGAATGAAGA GTACTTTATG TTTCCTGAGC 1500

CAAAGACTCC AGTTAATAAG AACCAGCATA AGAGAGAAAT ACTCACTACG CCAAATCGTT 1560

ACACTACACC CTCAAAAGCT AGAAACCAGT GCCTGAAAGA AACTCCAATT AAAATACCAG 1620

TAAATTCAAC AGGAACAGAC AAGTTAATGA CAGGTGTCAT TAGCCCTGAG AGGCGGTGCC 1680

GCTCAGTGGA ATTGGATCTC AACCAAGCAC ATATGGAGGA GACTCCAAAA AGAAAGGGAG 1740

CCAAAGTGTT TGGGAGCCTT GAAAGGGGGT TGGATAAGGT TATCACTGTG CTCACCAGGA 1800

GCAAAAGGAA GGGTTCTGCC AGAGACGGGC CCAGAAGACT AAAGCTTCAC TATAATGTGA 1860

CTACAACTAG ATTAGTGAAT CCAGATCAAC TGTTGAATGA AATAATGTCT ATTCTTCCAA 1920

AGAAGCATGT TGACTTTGTA CAAAAGGGTT ATACACTGAA GTGTCAAACA CAGTCAGATT lgβO

TTGGGAAAGT GACAATGCAA TTTGAATTAG AAGTGTGCCA GCTTCAAAAA CCCGATGTGG 2040

TGGGTATCAG GAGGCAGCGG CTTAAGGGCG ATGCCTGGGT TTACAAAAGA TTAGTGGAAG 2100

ACATCCTATC TAGCTGCAAG GTATAATTGA TGGATTCTTC CATCCTGCCG GATGAGTGTG 2160

GGTGTGATAC AGCCTACATA AAGACTGTTA TGATCGCTTT GATTTTAAAG TTCATTGGAA 2220

CTACCAACTT GTTTCTAAAG AGCTATCTTA AGACCAATAT CTCTTTGTTT TTAAACAAAA 2280

GATATTATTT TGTGTATGAA TCTAAATCAA GCCCATCTGT CATTATGTTA CTGTCTTTTT 2340

TAATCATGTG GTTTTGTATA TTAATAATTG TTGACTTTCT TAGATTCACT TCCATATGTG 2400

AATGTAAGCT CTTAACTATG TCTCTTTGTA ATGTGTAATT TCTTTCTGAA ATAAAACCAT 2460 TTGTGAATAT

Seq ID NO: 653 Protein sequence Protein Accession ft: NP_055606.1

1 11 21 31 41 51

M IKDYDELLKY YIELHETIGTG GIFAKVKLACH IILTGEMVAIK IIMDKNTLGSD LIPRIKTEIEA 60

LKNLRHQHIC QLYHVLETAN KIFMVLEYCP GGELFDYIIS QDRLSEEETR WFRQIVSAV 120

AYVHSQGYAH RDLKPENLLF DEYHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI 180

QGKSYLGSEA DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYDVPK WLSPSSILLL 240

QQMLQVDPKK RISMKNLLNH PWIMQDYNYP VEWQSKNPFI HLDDDCVTEL SVHHRNNRQT 300

MEDLISLWQY DHLTATYLLL LAKKARGKPV RLRLSSFSCG QASATPFTDI KSNNWSLEDV 360

TASDKNYVAG LIDYDWCEDD LSTGAATPRT SQFTKYWTES NGVESKSLTP ALCRTPANKL 420

KNKENVYTPK SAVKNEEYFM FPEPKTPVNK NQHKREILTT PNRYTTPSKA RNQCLKETPI 480

KIPVNSTGTD KLMTGVISPE RRCRSVELDL NQAHMEETPK RKGAKVFGSL ERGLDKVITV 540

LTRSKRKGSA RDGPRRLKLH YNVTTTRLVN PDQLLNEIMS ILPKKHVDFV QKGYTLKCQT 600 QSDFGKVTMQ FELEVCQLQK PD GIRRQR LKGDAWVYKR LVEDILSSCK V

Seq ID NO: 654 DNA sequence Nucleic Acid Accession ft: NM_000582 Coding sequence: 88..990

1 11 21 31 41 51 I I 1 I I I

GCAGAGCACA GCATCGTCGG GACCAGACTC GTCTCAGGCC AGTTGCAGCC TTCTCAGCCA 60 AACGCCGACC AAGGAAAACT CACTACCATG AGAATTGCAG TGATTTGCTT TTGCCTCCTA 120 GGCATCACCT GTGCCATACC AGTTAAACAG GCTGATTCTG GAAGTTCTGA GGAAAAGCAG 180

CTTTACAACA AATACCCAGA TGCTGTGGCC ACATGGCTAA ACCCTGACCC ATCTCAGAAG 240

CAGAATCTCC TAGCCCCACA GACCCTTCCA AGTAAGTCCA ACGAAAGCCA TGACCACATG 300

GATGATATGG ATGATGAAGA TGATGATGAC CATGTGGACA GCCAGGACTC CATTGACTCG 360

AACGACTCTG ATGATGTAGA TGACACTGAT GATTCTCACC AGTCTGATGA GTCTCACCAT 420

TCTGATGAAT CTGATGAACT GGTCACTGAT TTTCCCACGG ACCTGCCAGC AACCGAAGTT 480

TTCACTCCAG TTGTCCCCAC AGTAGACACA TATGATGGCC GAGGTGATAG TGTGGTTTAT 540

GGACTGAGGT CAAAATCTAA GAAGTTTCGC AGACCTGACA TCCAGTACCC TGATGCTACA 600

GACGAGGACA TCACCTCACA CATGGAAAGC GAGGAGTTGA ATGGTGCATA CAAGGCCATC 660

CCCGTTGCCC AGGACCTGAA CGCGCCTTCT GATTGGGACA GCCGTGGGAA GGACAGTTAT 720

GAAACGAGTC AGCTGGATGA CCAGAGTGCT GAAACCCACA GCCACAAGCA GTCCAGATTA 780

TATAAGCGGA AAGCCAATGA TGAGAGCAAT GAGCATTCCG ATGTGATTGA TAGTCAGGAA 840

CTTTCCAAAG TCAGCCGTGA ATTCCAGAGC CATGAATTTC ACAGCCATGA AGATATGCTG 900

GTTGTAGACC CCAAAAGTAA GGAAGAAGAT AAACACCTGA AATTTCGTAT TTCTCATGAA 960

TTAGATAGTG CATCTTCTGA GGTCAATTAA AAGGAGAAAA AATACAATTT CTCACTTTGC 1020

ATTTAGTCAA AAGAAAAAAT GCTTTATAGC AAAATGAAAG AGAACATGAA ATGCTTCTTT 1080

CTCAGTTTAT TGGTTGAATG TGTATCTATT TGAGTCTGGA AATAACTAAT GTGTTTGATA 1140

ATTAGTTTAG TTTGTGGCTT CATGGAAACT CCCTGTAAAC TAAAAGCTTC AGGGTTATGT 1200

CTATGTTCAT TCTATAGAAG AAATGCAAAC TATCACTGTA TTTTAATATT TGTTATTCTC 1260

TCATGAATAG AAATTTATGT AGAAGCAAAC AAAATACTTT TACCCACTTA AAAAGAGAAT 1320

ATAACATTTT ATGTCACTAT AATCTTTTGT TTTTTAAGTT AGTGTATATT TTGTTGTGAT 1380

TATCTTTTTG TGGTGTGAAT AAATCTTTTA TCTTGAATGT AATAAGAATT TGGTGGTGTC 1440

AATTGCTTAT TTGTTTTCCC ACGGTTGTCC AGCAATTAAT AAAACATAAC CTTTTTTACT 1500 GCCTAAAAAA AAAAAAAAAA AAAA

Seq ID NO: 655 Protein sequence Protein Accession ft: NP_000573

1 11 21 31 41 51

I I I I I I

MRIAVICFCL LGITCAIPVK QADSGSSEEK QLYNKYPDAV ATWLNPDPSQ KQNLLAPQTL 60

PSKSNESHDH MDDMDDEDDD DHVDSQDSID SNDSDDVDDT DDSHQSDESH HSDESDELVT 120

DFPTDLPATE VFTPWPTVD TYDGRGDSW YGLRSKSKKF RRPDIQYPDA TDEDITSHME 180

SEELNGAYKA IPVAQDLNAP SDWDSRGKDS YETSQLDDQS AETHSHKQSR LYKRKANDES 240 NEHSDVIDSQ ELSKVSREFH SHEFHSHEDM LWDPKSKEE DKHLKFRISH ELDSASSEVN

Seq ID NO: 656 DNA sequence

Nucleic Acid Accession ft: NM_003108.1

Coding sequence: 76..1401

1 11 21 31 41 51

I I I I I I

GGGGTGGGAG GGGGAGGGGG ACCTCCGCAC GAGACCCAGC GGCCCGGGTT GGAGCGTCCA 60

GCCCTGCAAC GGATCATGGT GCAGCAGGCG GAGAGCTTGG AAGCGGAGAG CAACCTGCCC 120

CGGGAGGCGC TGGACACGGA GGAGGGCGAA TTCATGGCTT GCAGCCCGGT GGCCCTGGAC 180

GAGAGCGACC CAGACTGGTG CAAGACGGCG TCGGGCCACA TCAAGCGGCC GATGAACGCG 240

TTCATGGTAT GGTCCAAGAT CGAACGCAGG AAGATCATGG AGCAGTCTCC GGACATGCAC 300

AACGCCGAGA TCTCCAAGAG GCTGGGCAAG CGCTGGAAAA TGCTGAAGGA CAGCGAGAAG 360

ATCCCGTTCA TCCGGGAGGC GGAGCGGCTG CGGCTCAAGC ACATGGCCGA CTACCCCGAC 420

TACAAGTACC GGCCCCGGAA AAAGCCCAAA ATGGACCCCT CGGCCAAGCC CAGCGCCAGC 480

CAGAGCCCAG AGAAGAGCGC GGCCGGCGGC GGCGGCGGGA GCGCGGGCGG AGGCGCGGGC 540

GGTGCCAAGA CCTCCAAGGG CTCCAGCAAG AAATGCGGCA AGCTCAAGGC CCCCGCGGCC 600

GCGGGCGCCA AGGCGGGCGC GGGCAAGGCG GCCCAGTCCG GGGACTACGG GGGCGCGGGC 660

GACGACTACG TGCTGGGCAG CCTGCGCGTG AGCGGCTCGG GCGGCGGCGG CGCGGGCAAG 720

ACGGTCAAGT GCGTGTTTCT GGATGAGGAC GACGACGACG ACGACGACGA CGACGAGCTG 780

CAGCTGCAGA TCAAACAGGA GCCGGACGAG GAGGACGAGG AACCACCGCA CCAGCAGCTC 840

CTGCAGCCGC CGGGGCAGCA GCCGTCGCAG CTGCTGAGAC GCTACAACGT CGCCAAAGTG 900

CCCGCCAGCC CTACGCTGAG CAGCTCGGCG GAGTCCCCCG AGGGAGCGAG CCTCTACGAC g60

GAGGTGCGGG CCGGCGCGAC CTCGGGCGCC GGGGGCGGCA GCCGCCTCTA CTACAGCTTC 1020

AAGAACATCA CCAAGCAGCA CCCGCCGCCG CTCGCGCAGC CCGCGCTGTC GCCCGCGTCC 1080

TCGCGCTCGG TGTCCACCTC CTCGTCCAGC AGCAGCGGCA GCAGCAGCGG CAGCAGCGGC 1140

GAGGACGCCG ACGACCTGAT GTTCGACCTG AGCTTGAATT TCTCTCAAAG CGCGCACAGC 1200

GCCAGCGAGC AGCAGCTGGG GGGCGGCGCG GCGGCCGGGA ACCTGTCCCT GTCGCTGGTG 1260

GATAAGGATT TGGATTCGTT CAGCGAGGGC AGCCTGGGCT CCCACTTCGA GTTCCCCGAC 1320

TACTGCACGC CGGAGCTGAG CGAGATGATC GCGGGGGACT GGCTGGAGGC GAACTTCTCC 1380

GACCTGGTGT TCACATATTG AAAGGCGCCC GCTGCTCGCT CTTTCTCTCG GAGGGTGCAG 1440

AGCTGGGTTC CTTGGGAGGA AGTTGTAGTG GTGATGATGA TGATGATGAT AATGATGATG 1500

ATGATGGTGG TGTTGATGGT GGCGGTGGTA GGGTGGAGGG GAGAGAAGAA GATGCTGATG 1560

ATATTGATAA GATGTCGTGA CGCAAAGAAA TTGGAAAACA TGATGAAAAT TTTGGTGGAG 1620

TTAAAGTGAA ATGAGTAGTT TTTAAACATT TTTCCTGTCC TTTTTTTGTC CCCCCTCCCT 1680

TCCTTTATCG TGTCTCAAGG TAGTTGCATA CCTAGTCTGG AGTTGTGATT ATTTTCCCAA 1740

AAAATGTGTT TTTGTAATTA CTATTTCTTT TTCCTGAAAT TCGTGATTGC AACAAAGGCA 1800

GAGGGGGCGG CGCGGCGGAG GGGAGGTAGG ACCCGCTCCG GAAGGCGCTG TTTGAAGCTT 1860

GTCGGTCTTT GAAGTCTGGA AGACGTCTGC AGAGGACCCT TTTGGCAGCA CAACTGTTAC 1920

TCTAGGGAGT TGGTGGAGAT ATTTTTTTTT CTTAAGAGAA CTTAAAGAAC TGGTGATTTT 1980 TTTTTAACAA AAAAAGGG Seq ID NO: 657 Protein sequence Protein Accession ft: NP_003099.1

1 11 21 31 41 51

I I I I I I

MVQQAESLEA ESNLPREALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS 60

KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP 120

RKKPKMDPSA KPSASQSPEK SAAGGGGGSA GGGAGGAKTS KGSSKKCGKL KAPAAAGAKA 180

GAGKAAQSGD YGGAGDDYVL GSLRVSGSGG GGAGKTVKCV FLDEDDDDDD DDDELQLQIK 240 QEPDEEDEEP PHQQLLQPPG QQPSQLLRRY NVAKVPASPT LSSSAESPEG ASLYDEVRAG 300

ATSGAGGGSR LYYSFKNITK QHPPPLAQPA LSPASSRSVS TSSSSSSGSS SGSSGEDADD 360

LMFDLSLNFS QSAHSASEQQ LGGGAAAGNL SLSLVDKDLD SFSEGSLGSH FEFPDYCTPE 420 LSEMIAGDWL EANFSDLVFT Y

Seq ID NO: 658 DNA sequence Nucleic Acid Accession ft: NM_001719 Coding sequence: 123..1418

11 21 31 41 51

GGGCGCAGCG GGGCCCGTCT GCAGCAAGTG ACCGACGGCC GGGACGGCCG CCTGCCCCCT 60 CTGCCACCTG GGGCGGTGCG GGCCCGGAGC CCGGAGCCCG GGTAGCGCGT AGAGCCGGCG 120 CGATGCACGT GCGCTCACTG CGAGCTGCGG CGCCGCACAG CTTCGTGGCG CTCTGGGCAC 180 CCCTGTTCCT GCTGCGCTCC GCCCTGGCCG ACTTCAGCCT GGACAACGAG GTGCACTCGA 240 GCTTCATCCA CCGGCGCCTC CGCAGCCAGG AGCGGCGGGA GATGCAGCGC GAGATCCTCT 300 CCATTTTGGG CTTGCCCCAC CGCCCGCGCC CGCACCTCCA GGGCAAGCAC AACTCGGCAC 360 CCATGTTCAT GCTGGACCTG TACAACGCCA TGGCGGTGGA GGAGGGCGGC GGGCCCGGCG 420 GCCAGGGCTT CTCCTACCCC TACAAGGCCG TCTTCAGTAC CCAGGGCCCC CCTCTGGCCA 480 GCCTGCAAGA TAGCCATTTC CTCACCGACG CCGACATGGT CATGAGCTTC GTCAACCTCG 540 TGGAACATGA CAAGGAATTG TTCCACCCAC GCTACCACCA TCGAGAGTTC CGGTTTGATC 600 TTTCCAAGAT CCCAGAAGGG GAAGCTGTCA CGGCAGCCGA ATTCCGGATC TACAAGGACT 660 ACATCCGGGA ACGCTTCGAC AATGAGACGT TCCGGATCAG CGTTTATCAG GTGCTCCAGG 720 AGCACTTGGG CAGGGAATCG GATCTCTTCC TGCTCGACAG CCGTACCCTC TGGGCCTCGG 780 AGGAGGGCTG GCTGGTGTTT GACATCACAG CCACCAGCAA CCACTGGGTG GTCAATCCGC 840 GGCACAACCT GGGCCTGCAG CTCTCGGTGG AGACGCTGGA TGGGCAGAGC ATCAACCCCA 900 AGTTGGCGGG CCTGATTGGG CGGCACGGGC CCCAGAACAA GCAGCCCTTC ATGGTGGCTT 960 TCTTCAAGGC CACGGAGGTC CACTTCCGCA GCATCCGGTC CACGGGGAGC AAACAGCGCA 1020 GCCAGAACCG CTCCAAGACG CCCAAGAACC AGGAAGCCCT GCGGATGGCC AACGTGGCAG 1080 AGAACAGCAG CAGCGACCAG AGGCAGGCCT GTAAGAAGCA CGAGCTGTAT GTCAGCTTCC 1140 GAGACCTGGG CTGGCAGGAC TGGATCATCG CGCCTGAAGG CTACGCCGCC TACTACTGTG 1200 AGGGGGAGTG TGCCTTCCCT CTGAACTCCT ACATGAACGC CACCAACCAC GCCATCGTGC 1260 AGACGCTGGT CCACTTCATC AACCCGGAAA CGGTGCCCAA GCCCTGCTGT GCGCCCACGC 1320 AGCTCAATGC CATCTCCGTC CTCTACTTCG ATGACAGCTC CAACGTCATC CTGAAGAAAT 1380 ACAGAAACAT GGTGGTCCGG GCCTGTGGCT GCCACTAGCT CCTCCGAGAA TTCAGACCCT 1440 TTGGGGCCAA GTTTTTCTGG ATCCTCCATT GCTCGCCTTG GCCAGGAACC AGCAGACCAA 1500 CTGCCTTTTG TGAGACCTTC CCCTCCCTAT CCCCAACTTT AAAGGTGTGA GAGTATTAGG 1560 AAACATGAGC AGCATATGGC TTTTGATCAG TTTTTCAGTG GCAGCATCCA ATGAACAAGA 1620 TCCTACAAGC TGTGCAGGCA AAACCTAGCA GGAAAAAAAA ACAACGCATA AAGAAAAATG 1680 GCCGGGCCAG GTCATTGGCT GGGAAGTCTC AGCCATGCAC GGACTCGTTT CCAGAGGTAA 1740 TTATGAGCGC CTACCAGCCA GGCCACCCAG CCGTGGGAGG AAGGGGGCGT GGCAAGGGGT 1800 GGGCACATTG GTGTCTGTGC GAAAGGAAAA TTGACCCGGA AGTTCCTGTA ATAAATGTCA 1860 CAATAAAACG AATGAATG

Seq ID NO: 65 Protein sequence Protein Accession ft: NP 001710

11 21 31 41 51

MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 60

ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG QGFSYPYKAV FSTQGPPLAS 120

LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY 180

IRERFDNETF RISVYQVLQE HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWWNPR 240

HNLGLQLSVE TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS 300

QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA PEGYAAYYCE 360

GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ LNAISVLYFD DSSNVILKKY 420

RNMWRACGC H

Seq ID NO: 660 DNA sequence Nucleic Acid Accession ft: Eos sequence Coding sequence: 211..1895

11 21 31 41 51

I I I I I

GGATCTGAGG GGCGCCCAGT CACTTCCTCC ACGTTCTCGT GCTGGGCGGG AGGAGCGGAT 60 GGGGCTTGGG AGGCAGCCTG CTCTCCAGTC CCTATCCACC CACAGGTTTT TTGGGTCGGA 120 GAGGAATTAT CTGATAAAAT TCCTGGGTTA ATATTTTTAA AAACGGAGAG TTTTTAAAAA 180 TGATTTTTTT CCCTCGAAAA TGACCTTTTT ATGCTTCGAA GCAGTTTGTC AACCAGCATA 240 GTGCTTTTTC TTTTCTCTTC TTTTTCTACG ATAAATGAAA GCATTTCTTC AAGAAAAAGG 300 CACAGGTTCC TTGAACAGCT GGATTCTGAT GGCACCATTA CTATAGAGGA GCAGATTGTC 360 CTTGTGCTGA AAGCGAAAGT ACAATGTGAA CTCAACATCA CAGCTCAACT CCAGGAGGGA 420 GAAGGTAATT GTTTCCCTGA ATGGGATGGA CTCATTTGTT GGCCCAGAGG AACAGTGGGG 480 AAAATATCGG CTGTTCCATG CCCTCCTTAT ATTTATGACT TCAACCATAA AGGAGTTGCT 540 TTCCGACACT GTAACCCCAA TGGAACATGG GATTTTATGC ACAGCTTAAA TAAAACATGG 600 GCCAATTATT CAGACTGCCT TCGCTTTCTG CAGCCAGATA TCAGCATAGG AAAGCAAGAA 660 TTCTTTGAAC GCCTCTATGT AATGTATACC GTTGGCTACT CCATCTCTTT TGGTTCCTTG 720 GCTGTGGCTA TTCTCATCAT TGGTTACTTC AGACGATTGC ATTGCACTAG GAACTATATC 780 CACATGCACT TATTTGTGTC TTTCATGCTG AGAGCTACAA GCATCTTTGT CAAAGACAGA 840 GTAGTCCATG CTCACATAGG AGTAAAGGAG CTGGAGTCCC TAATAATGCA GGATGACCCA 900 CAAAATTCCA TTGAGGCAAC TTCTGTGGAC AAATCACAAT ATATCGGGTG CAAGATTGCT 960 GTTGTGATGT TTATTTACTT CCTGGCTACA AATTATTATT GGATCCTGGT GGAAGGTCTC 1020 TACCTGCATA ATCTCATCTT TGTGGCTTTC TTTTCGGACA CCAAATACCT GTGGGGCTTC 1080 ATCTTGATAG GCTGGGGGTT TCCAGCAGCA TTTGTTGCAG CATGGGCTGT GGCACGAGCA 1140 ACTCTGGCTG ATGCGAGGTG CTGGGAACTT AGTGCTGGAG ACATCAAGTG GATTTATCAA 1200 GCACCGATCT TAGCAGCTAT TGGGCTGAAT TTTATTCTGT TTCTGAATAC GGTTAGAGTT 1260 CTAGCTACCA AAATCTGGGA GACCAATGCA GTTGGGCATG ACACAAGGAA GCAATACAGG 1320 AAACTGGCCA AATCGACACT GGTCCTGGTC CTAGTCTTTG GAGTGCATTA CATCGTGTTC 1380 GTATGCCTGC CTCACTCCTT CACTGGGCTC GGGTGGGAGA TCCGCATGCA CTGTGAGCTC 1440

TTCTTCAACT CCTTTCAGGG TTTCTTTGTG TCTATCATCT ACTGCTACTG CAATGGAGAG 1500

GTTCAGGCAG AGGTGAAGAA GATGTGGAGT CGGTGGAATC TCTCCGTGGA CTGGAAAAGG 1560

ACACCGCCAT GTGGCAGCGG CAGATGCGGC TCAGTGCTCA CCACCGTGAC GCACAGCACC 1620

AGCAGCCAGT CACAGGTGGC GGCCAGCACA CGCATGGTGC TTATCTCTGG CAAAGCTGCC 1680

AAGATCGCCA GCAGACAGCC TGACAGCCAC ATCACTTTAC CTGGCTATGT CTGGAGTAAC 1740

TCAGAGCAGG ACTGCCTGCC ACACTCTTTC CACGAGGAGA CCAAGGAAGA TAGTGGGAGG 1800

CAGGGAGATG ATATTCTAAT GGAGAAGCCT TCCAGGCCTA TGGAATCTAA CCCAGACACT 1860 GAAGGATGCC AAGGAGAAAC TGAGGATGTT CTCTGA

Seq ID NO: 661 Protein sequence Protein Accession ft: Eos sequence

11 21 31 41 51

I I I I I

MLRSSLSTSI VLFLFSSFST INESISSRKR HRFLEQLDSD GTITIEEQIV LVLKAKVQCE 60 LNITAQLQEG EGNCFPEWDG LICWPRGTVG KISAVPCPPY IYDFNHKGVA FRHCNPNGTW 120 DFMHSLNKTW ANYSDCLRFL QPDISIGKQE FFERLYVMYT VGYSISFGSL AVAILIIGYF 180 RRLHCTRNYI HMHLFVSFML RATSIFVKDR WHAHIGVKE LESLIMQDDP QNSIEATSVD 240 KSQYIGCKIA WMFIYFLAT NYYWILVEGL YLHNLIFVAF FSDTKYLWGF ILIGWGFPAA 300 FVAAWAVARA TLADARCWEL SAGDIKWIYQ APILAAIGLN FILFLNTVRV LATKIWETNA 360 VGHDTRKQYR KLAKSTLVLV LVFGVHYIVF VCLPHSFTGL GWEIRMHCEL FFNSFQGFFV 420 SIIYCYCNGE VQAEVKKMWS RWNLSVDWKR TPPCGSRRCG SVLTTVTHST SSQSQVAAST 480 RMVLISGKAA KIASRQPDSH ITLPGYVWSN SEQDCLPHSF HEETKEDSGR QGDDILMEKP 540 SRPMESNPDT EGCQGETEDV L

Seq ID NO: 662 DNA sequence Nucleic Acid Accession ft: NM_005048 Coding sequence: 143..1795

11 21 31 41 51

GGCCGGTGGC CCGGGCCCGA CCACCCCAGC TGCGCGTCGT TACTGGCCAC AAGTTTGCTC 60 TGGGCCAGCC AAGTTGGCAA CTTGGAAGCT TCTCCCGGGC TCTGGAGGAG GGTCCCTGCT 120 TCTTCCTACA GCCGTTCCGG GCATGGCCGG GCTGGGGGCG TCGCTCCACG TCTGGGGTTG 180 GCTAATGCTC GGCAGCTGCC TCCTGGCCAG AGGCCAGCTG GATTCTGATG GCACCATTAC 240 TATAGAGGAG CAGATTGTCC TTGTGCTGAA .AGCGAAAGTA CAATGTGAAC TCAACATCAC 300 AGCTCAACTC CAGGAGGGAG AAGGTAATTG TTTCCCTGAA TGGGATGGAG TCATTTGTTG 360 GCCCAGAGGA ACAGTGGGGA AAATATCGGC TGTTCCATGC CCTCCTTATA TTTATGACTT 420 CAACCATAAA GGAGTTGCTT TCCGACACTG TAACCCCAAT GGAACATGGG ATTTTATGCA 480 CAGCTTAAAT AAAACATGGG CCAATTATTC AGACTGCCTT CGCTTTCTGC AGCCAGATAT S40 CAGCATAGGA AAGCAAGAAT TCTTTGAACG CCTCTATGTA ATGTATACCG TTGGCTACTC 600 CATCTCTTTT GGTTCCTTGG CTGTGGCTAT TCTCATCATT GGTTACTTCA GACGATTGCA 660 TTGCACTAGG AACTATATCC ACATGCACTT ATTTGTGTCT TTCATGCTGA GAGCTACAAG 720 CATCTTTGTC AAAGACAGAG TAGTCCATGC TCACATAGGA GTAAAGGAGC TGGAGTCCCT 780 AATAATGCAG GATGACCCAC AAAATTCCAT TGAGGCAACT TCTGTGGACA AATCACAATA 840 TATCGGGTGC AAGATTGCTG TTGTGATGTT TATTTACTTC CTGGCTACAA ATTATTATTG 900 GATCCTGGTG GAAGGTCTCT ACCTGCATAA TCTCATCTTT GTGGCTTTCT TTTCGGACAC 960 CAAATACCTG TGGGGCTTCA TCTTGATAGG CTGGGGGTTT CCAGCAGCAT TTGTTGCAGC 1020 ATGGGCTGTG GCACGAGCAA CTCTGGCTGA TGCGAGGTGC TGGGAACTTA GTGCTGGAGA 1080 CATCAAGTGG ATTTATCAAG CACCGATCTT AGCAGCTATT GGGCTGAATT TTATTCTGTT 1140 TCTGAATACG GTTAGAGTTC TAGCTACCAA AATCTGGGAG ACCAATGCAG TTGGGCATGA 1200 CACAAGGAAG CAATACAGGA AACTGGCCAA ATCGACACTG GTCCTGGTCC TAGTCTTTGG 1260 AGTGCATTAC ATCGTGTTCG TATGCCTGCC TCACTCCTTC ACTGGGCTCG GGTGGGAGAT 1320 CCGCATGCAC TGTGAGCTCT TCTTCAACTC CTTTCAGGGT TTCTTTGTGT CTATCATCTA 1380 CTGCTACTGC AATGGAGAGG TTCAGGCAGA GGTGAAGAAG ATGTGGAGTC GGTGGAATCT 1440 CTCCGTGGAC TGGAAAAGGA CACCGCCATG TGGCAGCCGC AGATGCGGCT CAGTGCTCAC 1500 CACCGTGACG CACAGCACCA GCAGCCAGTC ACAGGTGGCG GCCAGCACAC GCATGGTGCT 1560 TATCTCTGGC AAAGCTGCCA AGATCGCCAG CAGACAGCCT GACAGCCACA TCACTTTACC 1620 TGGCTATGTC TGGAGTAACT CAGAGCAGGA CTGCCTGCCA CACTCTTTCC ACGAGGAGAC 1680 CAAGGAAGAT AGTGGGAGGC AGGGAGATGA TATTCTAATG GAGAAGCCTT CCAGGCCTAT 1740 GGAATCTAAC CCAGACACTG AAGGATGCCA AGGAGAAACT GAGGATGTTC TCTGAATGGA 1800 CATTTGTGGC TGACTTTCAT GGGCTGGTCC AATGGCTGGT TGTGTGAGAG GGCTTGGCTG 1860 ATACTCCTAT GCTTGAGTTC AAAGGCTGAA AATTCAGTTA AGGTGTTACT TAATAATAGT 1920 TTTTAGGCTC CATGAATTGG CTCCTGTAAA TACTAACGAC ATGAAAATGC AAGTGTCAAT 1980 GGAGTAGTTT ATTACCTTCT ATTGGCATCA AGTTTTCCTC TAAATTAATG TATGGTATTT 2040 GCTCTGTGAT TGTTCATTTT TTTCTGCTAC TTTTGGGTAG AAAAAAGATT CAATTGCTTG 2100 GCTGTAGCTT TCTCTCATAT ATATCACCCT AAATATAATG AAGATCTTTT AGTGTGTATC 2160 ATTTTCCTTT TAGAAACTAG TATTCTCTTA TTTCTTACTT TAATGTACTT CTATCACTGC 2220 ATTTATTTTG CCTGTGCATA GGAGCAATTA GGATCTAAAA AAATATATGG GAAGATAAAA 2280 GATCTAAGAA CAAGTACTTG CTGGAAAATT AGTTGGCTGG ACATTGATAA AATAATGCAT 2340 TTATAACAAT TACATGTGTT TTTGGGAACA AGGAAAATTT CTCAAAAAAG AATATTTCAC 2400 ACATCCCTTC TTTTGAATGG CCTCTTTGTG ACCAGCCAGA CCTCAGGTCT TCACTCTTTC 2460 TTCTTTGTAA ACCATGTCAT GTGGAAAGAT TTCCTCAGTT AGTGAGCTTG TGTCTGCAAA 2520 TTGATTTTGT TTGTAATGTA TTTTGATAGC AAATCATGCT GCATCTATAT CTTTTTCTTG 2580 TTTGAGCTGT TACTACATTG TACATGGCAT GTGGGATCAA TTAAAAATTT GTTTTAAAAA 2640 T

Seq ID NO: 663 Protein sequence Protein Accession ft: NP 005039

1 11 21 31 41 51

I I I I I I

MAGLGASLHV WGWLMLGSCL LARAQLDSDG TITIEEQIVL VLKAKVQCEL NITAQLQEGE 60 GNCFPEWDGL ICWPRGTVGK ISAVPCPPYI YDFNHKGVAF RHCNPNGTWD FMHSLNKTWA 120

NYSDCLRFLQ PDISIGKQEF FERLYVMYTV GYSISFGSLA VAILIIGYFR RLHCTRNYIH 180

MHLFVSFMLR ATSIFVKDRV VHAHIGVKEL ESLIMQDDPQ NSIEATSVDK SQYIGCKIAV 240 VMFIYFLATN YYWILVEGLY LHNLIFVAFF SDTKYLWGFI LIGWGFPAAF VAAWAVARAT 300

LADARCWELS AGDIKWIYQA PILAAIGLNF ILFLNTVRVL ATKIWETNAV GHDTRKQYRK 360

LAKSTLVLVL VFGVHYIVFV CLPHSFTGLG WEIRMHCELF FNSFQGFFVS IIYCYCNGEV 420

QAEVKKMWSR WNLSVDWKRT PPCGSRRCGS VLTTVTHSTS SQSQVAASTR MVLISGKAAK 480

IASRQPDSHI TLPGYVWSNS EQDCLPHSFH EETKEDSGRQ GDDILMEKPS RPMESNPDTE 540 GCQGETEDVL

Seq ID NO: 664 DNA sequence Nucleic Acid Accession ft: NM_012152 Coding sequence: 43..1104

11 21 31 41 51

CTTCTTTAAA TTTCTTTCTA GGATGTTCAC TTCTTCTCCA CAATGAATGA GTGTCACTAT 60 GACAAGCACA TGGACTTTTT TTATAATAGG AGCAACACTG ATACTGTCGA TGACTGGACA 120 GGAACAAAGC TTGTGATTGT TTTGTGTGTT GGGACGTTTT TCTGCCTGTT TATTTTTTTT 180 TCTAATTCTC TGGTCATCGC GGCAGTGATC AAAAACAGAA AATTTCATTT CCCCTTCTAC 240 TACCTGTTGG CTAATTTAGC TGCTGCCGAT TTCTTCGCTG GAATTGCCTA TGTATTCCTG 300 ATGTTTAACA CAGGCCCAGT TTCAAAAACT TTGACTGTCA ACCGCTGGTT TCTCCGTCAG 360 GGGCTTCTGG ACAGTAGCTT GACTGCTTCC CTCACCAACT TGCTGGTTAT CGCCGTGGAG 420 AGGCACATGT CAATCATGAG GATGCGGGTC CATAGCAACC TGACCAAAAA GAGGGTGACA 480 CTGCTCATTT TGCTTGTCTG GGCCATCGCC ATTTTTATGG GGGCGGTCCC CACACTGGGC 540 TGGAATTGCC TCTGCAACAT CTCTGCCTGC TCTTCCCTGG CCCCCATTTA CAGCAGGAGT 600 TACCTTGTTT TCTGGACAGT GTCCAACCTC ATGGCCTTCC TCATCATGGT TGTGGTGTAC 660 CTGCGGATCT ACGTGTACGT CAAGAGGAAA ACCAACGTCT TGTCTCCGCA TACAAGTGGG 720 TCCATCAGCC GCCGGAGGAC ACCCATGAAG CTAATGAAGA CGGTGATGAC TGTCTTAGGG 780 GCGTTTGTGG TATGCTGGAC CCCGGGCCTG GTGGTTCTGC TCCTCGACGG CCTGAACTGC 840 AGGCAGTGTG GCGTGCAGCA TGTGAAAAGG TGGTTCCTGC TGCTGGCGCT GCTCAACTCC 900 GTCGTGAACC CCATCATCTA CTCCTACAAG GACGAGGACA TGTATGGCAC CATGAAGAAG 960 ATGATCTGCT GCTTCTCTCA GGAGAACCCA GAGAGGCGTC CCTCTCGCAT CCCCTCCACA 1020 GTCCTCAGCA GGAGTGACAC AGGCAGCCAG TACATAGAGG ATAGTATTAG CCAAGGTGCA 1080 GTCTGCAATA AAAGCACTTC CTAAACTCTG GATGCCTCTC GGCCCACCCA GGTGATGACT 1140 GTCTTAGG

Seq ID NO: 665 Protein sequence Protein Accession ft: NP_036284

11 21 31 41 51

I ^• I I I

MNECHYDKHM DFFYNRSNTD TVDDWTGTKL VIVLCVGTFF C 1LFIFFSNSL VIAAVIKNRK 60 FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN RWFLRQGLLD SSLTASLTNL 120 LVIAVERHMS IMRMRVHSNL TKKRVTLLIL LVWAIAIFMG AVPTLGWNCL CNISACSSLA 180 PIYSRSYLVF WTVSNLMAFL IMVWYLRIY VYVKRKTNVL SPHTSGSISR RRTPMKLMKT 240 VMTVLGAFW CWTPGLWLL LDGLNCRQCG VQHVKRWFLL LALLNSWNP IIYSYKDEDM 300 YGTMKKMICC FSQENPERRP SRIPSTVLSR SDTGSQYIED SISQGAVCNK STS

Seq ID NO: 666 DNA sequence Nucleic Acid Accession ft: NM_002821 Coding sequence: 150..3362

11 21 31 41 51

AACTCCCGCC TCGGGACGCC TCGGGGTCGG GCTCCGGCTG CGGCTGCTGC TGCGGCGCCC 60 GCGCTCCGGT GCGTCCGCCT CCTGTGCCCG CCGCGGAGCA GTCTGCGGCC CGCCGTGCGC 120 CCTCAGCTCC TTTTCCTGAG CCCGCCGCGA TGGGAGCTGC GCGGGGATCC CCGGCCAGAC 180 CCCGCCGGTT GCCTCTGCTC AGCGTCCTGC TGCTGCCGCT GCTGGGCGGT ACCCAGACAG 240 CCATTGTCTT CATCAAGCAG CCGTCCTCCC AGGATGCACT GCAGGGGCGC CGGGCGCTGC 300 TTCGCTGTGA GGTTGAGGCT CCGGGCCCGG TACATGTGTA CTGGCTGCTC GATGGGGCCC 360 CTGTCCAGGA CACGGAGCGG CGTTTCGCCC AGGGCAGCAG CCTGAGCTTT GCAGCTGTGG 420 ACCGGCTGCA GGACTCTGGC ACCTTCCAGT GTGTGGCTCG GGATGATGTC ACTGGAGAAG 480 AAGCCCGCAG TGCCAACGCC TCCTTCAACA TCAAATGGAT TGAGGCAGGT CCTGTGGTCC 540 TGAAGCATCC AGCCTCGGAA GCTGAGATCC AGCCACAGAC CCAGGTCACA CTTCGTTGCC 600 ACATTGATGG GCACCCTCGG CCCACCTACC AATGGTTCCG AGATGGGACC CCCCTTTCTG 660 ATGGTCAGAG CAACCACACA GTCAGCAGCA AGGAGCGGAA CCTGACGCTC CGGCCAGCTG 720 GTCCTGAGCA TAGTGGGCTG TATTCCTGCT GCGCCCACAG TGCTTTTGGC CAGGCTTGCA 780 GCAGCCAGAA CTTCACCTTG AGCATTGCTG ATGAAAGCTT TGCCAGGGTG GTGCTGGCAC 840 CCCAGGACGT GGTAGTAGCG AGGTATGAGG AGGCCATGTT CCATTGCCAG TTCTCAGCCC 900 AGCCACCCCC GAGCCTGCAG TGGCTCTTTG AGGATGAGAC TCCCATCACT AACCGCAGTC 960 GCCCCCCACA CCTCCGCAGA GCCACAGTGT TTGCCAACGG GTCTCTGCTG CTGACCCAGG 1020 TCCGGCCACG CAATGCAGGG ATCTACCGCT GCATTGGCCA GGGGCAGAGG GGCCCACCCA 1080 TCATCCTGGA AGCCACACTT CACCTAGCAG AGATTGAAGA CATGCCGCTA TTTGAGCCAC 1140 GGGTGTTTAC AGCTGGCAGC GAGGAGCGTG TGACCTGCCT TCCCCCCAAG GGTCTGCCAG 1200 AGCCCAGCGT GTGGTGGGAG CACGCGGGAG TCCGGCTGCC CACCCATGGC AGGGTCTACC 1260 AGAAGGGCCA CGAGCTGGTG TTGGCCAATA TTGCTGAAAG TGATGCTGGT GTCTACACCT 1320 GCCACGCGGC CAACCTGGCT GGTCAGCGGA GACAGGATGT CAACATCACT GTGGCCACTG 1380 TGCCCTCCTG GCTGAAGAAG CCCCAAGACA GCCAGCTGGA GGAGGGCAAA CCCGGCTACT 1440 TGGATTGCCT GACCCAGGCC ACACCAAAAC CTACAGTTGT CTGGTACAGA AACCAGATGC 1500 TCATCTCAGA GGACTCACGG TTCGAGGTCT TCAAGAATGG GACCTTGCGC ATCAACAGCG 1560 TGGAGGTGTA TGATGGGACA TGGTACCGTT GTATGAGCAG CACCCCAGCC GGCAGCATCG 1620 AGGCGCAAGC CCGTGTCCAA GTGCTGGAAA AGCTCAAGTT CACACCACCA CCCCAGCCAC 1680 AGCAGTGCAT GGAGTTTGAC AAGGAGGCCA CGGTGCCCTG TTCAGCCACA GGCCGAGAGA 1740 AGCCCACTAT TAAGTGGGAA CGGGCAGATG GGAGCAGCCT CCCAGAGTGG GTGACAGACA 1800 ACGCTGGGAC CCTGCATTTT GCCCGGGTGA CTCGAGATGA CGCTGGCAAC TACACTTGCA 1860 TTGCCTCCAA CGGGCCGCAG GGCCAGATTC GTGCCCATGT CCAGCTCACT GTGGCAGTTT 1920 TTATCACCTT CAAAGTGGAA CCAGAGCGTA CGACTGTGTA CCAGGGCCAC ACAGCCCTAC 1980 TGCAGTGCGA GGCCCAGGGG GACCCCAAGC CGCTGATTCA GTGGAAAGGC AAGGACCGCA 2040 TCCTGGACCC CACCAAGCTG GGACCCAGGA TGCACATCTT CCAGAATGGC TCCCTGGTGA 2100 TCCATGACGT GGCCCCTG GA TCAGGCC GCTACACCTG CATTGCAGGC AACAGCTGCA 2160

ACATCAAGCA CACGGAGGCC CCCCTCTATG TCGTGGACAA GCCTGTGCCG GAGGAGTCGG 2220

AGGGCCCTGG CAGCCCTCCC CCCTACAAGA TGATCCAGAC CATTGGGTTG TCGGTGGGTG 2280

CCGCTGTGGC CTACATCATT GCCGTGCTGG GCCTCATGTT CTACTGCAAG AAGCGCTGCA 2340

5 AAGCCAAGCG GCTGCAGAAG CAGCCCGAGG GCGAGGAGCC AGAGATGGAA TGCCTCAACG 2400

GAGGGCCTTT GCAGAACGGG CAGCCCTCAG CAGAGATCGA AGAAGAAGTG GCCTTGACCA 2460

GCTTGGGCTC CGGCCCCGCG GCCACCAACA AACGCCACAG CACAAGTGAT AAGATGCACT 2520

TCCCACGGTC TAGCCTGCAG CCCATCACCA CGCTGGGGAA GAGTGAGTTT GGGGAGGTGT 2580

TCCTGGCAAA GGCTCAGGGC TTGGAGGAGG GAGTGGCAGA GACCCTGGTA CTTGTGAAGA 2640 0 GCCTGCAGAC GAAGGATGAG CAGCAGCAGC TGGACTTCCG GAGGGAGTTG GAGATGTTTG 2700

GGAAGCTGAA CCACGCCAAC GTGGTGCGGC TCCTGGGGCT GTGCCGGGAG GCTGAGCCCC 2760

ACTACATGGT GCTGGAATAT GTGGATCTGG GAGACCTCAA GCAGTTCCTG AGGATTTCCA 2820

AGAGCAAGGA TGAAAAATTG AAGTCACAGC CCCTCAGCAC CAAGCAGAAG GTGGCCCTAT 2880

GCACCCAGGT AGCCCTGGGC ATGGAGCACC TGTCCAACAA CCGCTTTGTG CATAAGGACT 2940 5 TGGCTGCGCG TAACTGCCTG GTCAGTGCCC AGAGACAAGT GAAGGTGTCT GCCCTGGGCC 3000

TCAGCAAGGA TGTGTACAAC AGTGAGTACT ACCACTTCCG CCAGGCCTGG GTGCCGCTGC 3060

GCTGGATGTC CCCCGAGGCC ATCCTGGAGG GTGACTTCTC TACCAAGTCT GATGTCTGGG 3120

CCTTCGGTGT GCTGATGTGG GAAGTGTTTA CACATGGAGA GATGCCCCAT GGTGGGCAGG 3180

- CAGATGATGA AGTACTGGCA GATTTGCAGG CTGGGAAGGC TAGACTTCCT CAGCCCGAGG 3240 0 GCTGCCCTTC CAAACTCTAT CGGCTGATGC AGCGCTGCTG GGCCCTCAGC CCCAAGGACC 3300

GGCCCTCCTT CAGTGAGATT GCCAGCGCCC TGGGAGACAG CACCGTGGAC AGCAAGCCGT 3360

GAGGAGGGAG CCCGCTCAGG ATGGCCTGGG CAGGGGAGGA CATCTCTAGA GGGAAGCTCA 3420

CAGCATGATG GGCAAGATCC CTGTCCTCCT GGGCCCTGAG GTGCCCTAGT GCAACAGGCA 3480

TTGCTGAGGT CTGAGCAGGG CCTGGCCTTT CCTCCTCTTC CTCACCCTCA TCCTTTGGGA 3540 5 GGCTGACTTG GACCCAAACT GGGCGACTAG GGCTTTGAGC TGGGCAGTTT CCCCTGCCAC 3600

CTCTTCCTCT ATCAGGGACA GTGTGGGTGC CACAGGTAAC CCCAATTTCT GGCCTTCAAC 3660

TTCTCCCCTT GACCGGGTCC AACTCTGCCA CTCATCTGCC AACTTTGCCT GGGGAGGGCT 3720

AGGCTTGGGA TGAGCTGGGT TTGTGGGGAG TTCCTTAATA TTCTCAAGTT CTGGGCACAC 3780

_A AGGGTTAATG AGTCTCTTGC CCACTGGTCC ACTTGGGGGT CTAGACCAGG ATTATAGAGG 3840 0 ACACAGCAAG TGAGTCCTCC CCACTCTGGG CTTGTGCACA CTGACCCAGA CCCACGTCTT 3g00

CCCCACCCTT CTCTCCTTTC CTCATCCTAA GTGCCTGGCA GATGAAGGAG TTTTCAGGAG 3960

CTTTTGACAC TATATAAACC GCCCTTTTTG TATGCACCAC GGGCGGCTTT TATATGTAAT 4020

TGCAGCGTGG GGTGGGTGGG CATGGGAGGT AGGGGTGGGC CCTGGAGATG AGGAGGGTGG 4080

GCCATCCTTA CCCCACACTT TTATTGTTGT CGTTTTTTGT TTGTTTTGTT TTTTTGTTTT 4140 5 TGTTTTTGTT TTTACACTCG CTGCTCTCAA TAAATAAGCC TTTTTTA

Seq ID NO: 667 Protein sequence Protein Accession ft: NP 002812 0 11 21 31 41 51

MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL LRCEVEAPGP 60 VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN 120 IKWIEAGPW LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS 180 5 KERNLTLRPA GPEHSGLYSC CAHSAFGQAC SSQNFTLSIA DESFARWLA PQDVWARYE 240 EAMFHCQFSA QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR 300 CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG 360 VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR RQDVNITVAT VPSWLKKPQD 420 SQLEEGKPGY LDCLTQATPK PTWWYRNQM LISEDSRFEV FKNGTLRINS VEVYDGTWYR 480 0 CMSSTPAGSI EAQARVQVLE KLKFTPPPQP QQCMEFDKEA TVPCSATGRE KPTIKWERAD 540 GSSLPEWVTD NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER 600 TTVYQGHTAL LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR MHIFQNGSLV IHDVAPEDSG 660 RYTCIAGNSC NIKHTEAPLY WDKPVPEES EGPGSPPPYK MIQTIGLSVG AAVAYIIAVL 720 GLMFYCKKRC KAKRLQKQPE GEEPEMECLN GGPLQNGQPS AEIQEEVALT SLGSGPAATN 780 5 KRHSTSDKMH FPRSSLQPIT TLGKSEFGEV FLAKAQGLEE GVAETLVLVK SLQTKDEQQQ 840 LDFRRELEMF GKLNHANWR LLGLCREAEP HYMVLEYVDL GDLKQFLRIS KSKDEKLKSQ goo PLSTKQKVAL CTQVALGMEH LSNNRFVHKD LAARNCLVSA QRQVKVSALG LSKDVYNSEY 960 YHFRQAWVPL RWMSPEAILE GDFSTKSDVW AFGVLMWEVF THGEMPHGGQ ADDEVLADLQ 1020 AGKARLPQPE GCPSKLYRLM QRCWALSPKD RPSFSEIASA LGDSTVDSKP 0

Seq ID NO: 668 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 1..1389 5 11 21 31 41 51

ATGGGCTACC AGAGGCAGGA GCCTGTCATC CCGCCGCAGA GAGATTTAGA TGACAGAGAA 60 ACCCTTGTTT CTGAACATGA GTATAAAGAG AAAACCTGTC AGTCTGCTGC TCTTTTTAAT 120 GTTGTCAACT CGATTATAGG ATCTGGΓATA ATAGGATTGC CTTATTCAAT GAAGCAAGCT 180 GGGTTTCCTT TGGGAATATT GCTTTTATTC TGGGTTTCAT ATGTTACGGA CTTTTCCCTT 240 GTTTTATTGA TAAAAGGAGG GGCCCTGTCT GGAACAGATA CCTACCAGTC TTTGGTCAAT 300 AAAACTTTCG GCTTTCCAGG GTATCTGCTC CTCTCTGTTC TTCAGTTTTT GTATCCTTTT 360 ATAGCAATGA TAAGTTACAA TATAATAGCT GGAGATACTT TGAGCAAAGT TTTTCAAAGA 420 ATCCCAGGAG TTGATCCTGA AAACGTGTTT ATTGGTCGCC ACTTCATTAT TGGACTTTCC 480 5 ACAGTTACCT TTACTCTGCC TTTATCCTTG TACCGAAATA TAGCAAAGCT TGGAAAGGTC 540 TCCCTCATCT CTACAGGTTT AACAACTCTG ATTCTTGGAA TTGTAATGGC AAGGGCAATT 600 TCACTGGGTC CACACATACC AAAAACAGAA GACGCTTGGG TATTTGCAAA GCCCAATGCC 660 ATTCAAGCGG TCGGGGTTAT GTCTTTTGCA TTTATTTGCC ACCATAACTC CTTCTTAGTT 720 TACAGTTCTC TAGAAGAACC CACAGTAGCT AAGTGGTCCC GCCTTATCCA TATGTCCATC 780 GTGATTTCTG TATTTATCTG TATATTCTTT GCTACATGTG GATACTTGAC ATTTACTGGC 840 TTCACCCAAG GGGACTTATT TGAAAATTAC TGCAGAAATG ATGACCTGGT AACATTTGGA 900 AGATTTTGTT ATGGTGTCAC TGTCATTTTG ACATACCCTA TGGAATGCTT TGTGACAAGA 960 GAGGTAATTG CCAATGTGTT TTTTGGTGGG AATCTTTCAT CGGTTTTCCA CATTGTTGTA 1020 ACAGTGATGG TCATCACTGT AGCCACGCTT GTGTCATTGC TGATTGATTG CCTCGGGATA 1080 5 GTTCTAGAAC TCAATGGTGT GCTCTGTGCA ACTCCCCTCA TTTTTATCAT TCCATCAGCC 1140 TGTTATCTGA AACTGTCTGA AGAACCAAGG ACACACTCCG ATAAGATTAT GTCTTGTGTC 1200 ATGCTTCCCA TTGGTGCTGT GGTGATGGTT TTTGGATTCG TCATGGCTAT TACAAATACT 1260 CAAGACTGCA CCCATGGGCA GGAAATGTTC TACTGCTTTC CTGACAATTT CTCTCTCACA 1320 AATACCTCAG AGTCTCATGT TCAGCAGACA ACACAACTTT CTACTTTAAA TATTAGTATC 1380 TTTCAATGA

Seq ID NO: 669 Protein sequence Protein Accession ft: Eos sequence

1 11 21 31 41 51

I I I I I I

MGYQRQEPVI PPQRDLDDRE TLVSEHEYKE KTCQSAALFN WNSIIGSGI IGBPYSMKQA 60

GFPLGILLLF WVSYVTDFSL VLLIKGGALS GTDTYQSLVN KTFGFPGYLL LSVLQFLYPF 120

IAMISYNIIA GDTLSKVFQR IPGVDPENVF IGRHFIIGLS TVTFTLPLSL YRNIAKLGKV 180

SLISTGLTTL ILGIVMARAI SLGPHIPKTE DAWVFAKPNA IQAVGVMSFA FICHHNSFLV 240

YSSLEEPTVA KWSRLIHMSI VISVFICIFF ATCGYLTFTG FTQGDLFENY CRNDDLVTFG 300

RFCYGVTVIL TYPMECFVTR EVIANVFFGG NLSSVFHIW TVMVITVATL VSLLIDCLGI 360

VLELNGVLCA TPLIFIIPSA CYLKLSEEPR THSDKIMSCV MLPIGA MV FGFVMAITNT 420 QDCTHGQEMF YCFPDNFSLT NTSESHVQQT TQLSTLNISI FQ

Seq ID NO: 670 DNA sequence Nucleic Acid Accession ft: Eos sequence Coding sequence: 1..1284

1 11 21 31 41 51

I I I I I I

ATGGGCTACC AGAGGCAGGA GCCTGTCATC CCGCCGCAGA GAGGATTGCC TTATTCAATG 60

AAGCAAGCTG GGTTTCCTTT GGGAATATTG CTTTTATTCT GGGTTTCATA TGTTACAGAC 120

TTTTCCCTTG TTTTATTGAT AAAAGGAGGG GCCCTCTCTG GAACAGATAC CTACCAGTCT 180

TTGGTCAATA AAACTTTCGG GTTTCCAGGG TATCTGCTCC TCTCTGTTCT TCAGTTTTTG 240

TATCCTTTTA TAGCAATGAT AAGTTACAAT ATAATAGCTG GAGATACTTT GAGCAAAGTT 300

TTTCAAAGAA TCCCAGGAGT TGATCCTGAA AACGTGTTTA TTGGTCGCCA CTTCATTATT 360

GGACTTTCCA CAGTTACCTT TACTCTGCCT TTATCCTTGT ACCGAAATAT AGCAAAGCTT 420

GGAAAGGTCT CCCTCATCTC TACAGGTTTA ACAACTCTGA TTCTTGGAAT TGTAATGGCA 480

AGGGCAATTT CACTGGGTCC ACACATACCA AAAACAGAAG ACGCTTGGGT ATTTGCAAAG 540

CCCAATGCCA TTCAAGCGGT CGGGGTTATG TCTTTTGCAT TTATTTGCCA CCATAACTCC 600

TTCTTAGTTT ACAGTTCTCT AGAAGAACCC ACAGTAGCTA AGTGGTCCCG CCTTATCCAT 660

ATGTCCATCG TGATTTCTGT ATTTATCTGT ATATTCTTTG CTACATGTGG ATACTTGACA 720

TTTACTGGCT TCACCCAAGG GGACTTATTT GAAAATTACT GCAGAAATGA TGACCTGGTA 780

ACATTTGGAA GATTTTGTTA TGGTGTCACT GTCATTTTGA CATACCCTAT GGAATGCTTT 840

GTGACAAGAG AGGTAATTGC CAATGTGTTT TTTGGTGGGA ATCTTTCATC GGTTTTCCAC 900

ATTGTTGTAA CAGTGATGGT CATCACTGTA GCCACGCTTG TGTCATTGCT GATTGATTGC 960

CTCGGGATAG TTCTAGAACT CAATGGTGTG CTCTGTGCAA CTCCCCTCAT TTTTATCATT 1020

CCATCAGCCT GTTATCTGAA ACTGTCTGAA GAACCAAGGA CACACTCCGA TAAGATTATG 1080

TCTTGTGTCA TGCTTCCCAT TGGTGCTGTG GTGATGGTTT TTGGATTCGT CATGGCTATT 1140

ACAAATACTC AAGACTGCAC CCATGGGCAG GAAATGTTCT ACTGCTTTCC TGACAATTTC 1200

TCTCTCACAA ATACCTCAGA GTCTCATGTT CAGCAGACAA CACAACTTTC TACTTTAAAT 1260 ATTAGTATCT TTCAACTCGA GTAA

Seq ID NO: 671 Protein sequence Protein Accession ft : Eos sequence

1 11 21 31 41 51

I I I I I I

MGYQRQEPVI PPQRGLPYSM KQAGFPLGIL LLFWVSYVTD FSLVLLIKGG ALSGTDTYQS 60

LVNKTFGFPG YLLLSVLQFL YPFIAMISYN IIAGDTLSKV FQRIPGVDPE NVFIGRHFII 120

GLSTVTFTLP LSLYRNIAKL GKVSLISTGL TTLILGIVMA RAISLGPHIP KTEDAWVFAK 180

PNAIQAVGVM SFAFICHHNS FLVYSSLEEP TVAKWSRLIH MSIVISVFIC IFFATCGYLT 240

FTGFTQGDLF ENYCRNDDLV TFGRFCYGVT VILTYPMECF VTREVIANVF FGGNLSSVFH 300

IWTVMVITV ATLVSLLIDC LGIVLELNGV LCATPLIFII PSACYLKLSE EPRTHSDKIM 360

SCVMLPIGAV VMVFGFVMAI TNTQDCTHGQ EMFYCFPDNF SLTNTSESHV QQTTQLSTLN 420 ISIFQLE

Seq ID NO: 672 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 1..1203

21 31 51

ATGGGCTACC AGAGGCAGGA GCCTGTCATC CCGCCGCAGT TTTCCCTTGT TTTATTGATA 60

AAAGGAGGGG CCCTCTCTGG AACAGATACC TACCAGTCTT TGGTCAATAA AACTTTCGGC 120

TTTCCAGGGT ATCTGCTCCT CTCTGTTCTT CAGTTTTTGT ATCCTTTTAT AGCAATGATA 180

AGTTACAATA TAATAGCTGG AGATACTTTG AGCAAAGTTT TTCAAAGAAT CCCAGGAGTT 240

GATCCTGAAA ACGTGTTTAT TGGTCGCCAC TCATTATTG GACTTTCCAC AGTTACCTTT 300

ACTCTGCCTT TATCCTTGTA CCGAAATATA GCAAAGCTTG GAAAGGTCTC CCTCATCTCT 360

ACAGGTTTAA CAACTCTGAT TCTTGGAATT GTAATGGCAA GGGCAATTTC ACTGGGTCCA 420

CACATACCAA AAACAGAAGA CGCTTGGGTA TTTGCAAAGC CCAATGCCAT TCAAGCGGTC 480

GGGGTTATGT CTTTTGCATT TATTTGCCAC CATAACTCCT TCTTAGTTTA CAGTTCTCTA 540

GAAGAACCCA CAGTAGCTAA GTGGTCCCGC CTTATCCATA TGTCCATCGT GATTTCTGTA 600

TTTATCTGTA TATTCTTTGC TACATGTGGA TACTTGACAT TTACTGGCTT CACCCAAGGG 660

GACTTATTTG AAAATTACTG CAGAAATGAT GACCTGGTAA CATTTGGAAG ATTTTGTTAT 720

GGTGTCACTG TCATTTTGAC ATACCCTATG GAATGCTTTG TGACAAGAGA GGTAATTGCC 780

AATGTGTTTT TTGGTGGGAA TCTTTCATCG GTTTTCCACA TTGTTGTAAC AGTGATGGTC 840

ATCACTGTAG CCACGCTTGT GTCATTGCTG ATTGATTGCC TCGGGATAGT TCTAGAACTC 900

AATGGTGTGC TCTGTGCAAC TCCCCTCATT TTTATCATTC CATCAGCCTG TTATCTGAAA 960

CTGTCTGAAG AACCAAGGAC ACACTCCGAT AAGATTATGT CTTGTGTCAT GCTTCCCATT 1020 GGTGCTGTGG TGATGGTTTT TGGATTCGTC ATGGCTATTA CAAATACTCA AGACTGCACC 1080

CATGGGCAGG AAATGTTCTA CTGCTTTCCT GACAATTTCT CTCTCACAAA TACCTCAGAG 1140

TCTCATGTTC AGCAGACAAC ACAACTTTCT ACTTTAAATA TTAGTATCTT TCAACTCGAG 1200 TAA

Seq ID NO: 673 Protein sequence Protein Accession ft : Eos sequence

1 11 21 31 41 51

I I I I I I

MGYQRQEPVI PPQFSLVLLI KGGALSGTDT YQSLVNKTFG FPGYLLLSVL QFLYPFIAMI 60

SYNIIAGDTL SKVFQRIPGV DPENVFIGRH FIIGLSTVTF TLPLSLYRNI AKLGKVSLIS 120

TGLTTLILGI VMARAISLGP HIPKTEDAWV FAKPNAIQAV GVMSFAFICH HNSFLVYSSL 180

EEPTVAKWSR LIHMSIVISV FICIFFATCG YLTFTGFTQG DLFENYCRND DLVTFGRFCY 240

GVTVILTYPM ECFVTREVIA NVFFGGNLSS VFHIWTVMV ITVATLVSLL IDCLGIVLEL 300

NGVLCATPLI FIIPSACYLK LSEEPRTHSD KIMSCVMLPI GAWMVFGFV MAITNTQDCT 360 HGQEMFYCFP DNFSLTNTSE SHVQQTTQLS TLNISIFQLE

Seq ID NO: 674 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 1..1140

1 11 21 31 41 51

I I I I I I

ATGGGCTACC AGAGGCAGGA GCCTGTCATC CCGCCGCAGG TCAATAAAAC TTTCGGCTTT 60

CCAGGGTATC TGCTCCTCTC TGTTCTTCAG TTTTTGTATC CTTTTATAGC AATGATAAGT 120

TACAATATAA TAGCTGGAGA TACTTTGAGC AAAGTTTTTC AAAGAATCCC AGGAGTTGAT 180

CCTGAAAACG TGTTTATTGG TCGCCACTTC ATTATTGGAC TTTCCACAGT TACCTTTACT 240

CTGCCTTTAT CCTTGTACCG AAATATAGCA AAGCTTGGAA AGGTCTCCCT CATCTCTACA 300

GGTTTAACAA CTCTGATTCT TGGAATTGTA ATGGCAAGGG CAATTTCACT GGGTCCACAC 360

ATACCAAAAA CAGAAGACGC TTGGGTATTT GCAAAGCCCA ATGCCATTCA AGCGGTCGGG 420

GTTATGTCTT TTGCATTTAT TTGCCACCAT AACTCCTTCT TAGTTTACAG TTCTCTAGAA 480 GAACCCACAG TAGCTAAGTG GTCCCGCCTT ATCCATATGT CCATCGTGAT TTCTGTATTT 540

ATCTGTATAT TCTTTGCTAC ATGTGGATAC TTGACATTTA CTGGCTTCAC CCAAGGGGAC 600

TTATTTGAAA ATTACTGCAG AAATGATGAC CTGGTAACAT TTGGAAGATT TTGTTATGGT 660

GTCACTGTCA TTTTGACATA CCCTATGGAA TGCTTTGTGA CAAGAGAGGT AATTGCCAAT 720

GTGTTTTTTG GTGGGAATCT TTCATCGGTT TTCCACATTG TTGTAACAGT GATGGTCATC 780 ACTGTAGCCA CGCTTGTGTC ATTGCTGATT GATTGCCTCG GGATAGTTCT AGAACTCAAT 840

GGTGTGCTCT GTGCAACTCC CCTCATTTTT ATCATTCCAT CAGCCTGTTA TCTGAAACTG 900

TCTGAAGAAC CAAGGACACA CTCCGATAAG ATTATGTCTT GTGTCATGCT TCCCATTGGT 960

GCTGTGGTGA TGGTTTTTGG ATTCGTCATG GCTATTACAA ATACTCAAGA CTGCACCCAT 1020

GGGCAGGAAA TGTTCTACTG CTTTCCTGAC AATTTCTCTC TCACAAATAC CTCAGAGTCT 1080 CATGTTCAGC AGACAACACA ACTTTCTACT TTAAATATTA GTATCTTTCA ACTCGAGTAA

Seq ID NO: 675 Protein sequence Protein Accession ft: Eos sequence 1 11 21 31 41 51

I I I I I I

MGYQRQEPVI PPQVNKTFGF PGYLLLSVLQ FLYPFIAMIS YNIIAGDTLS KVFQRIPGVD 60

PENVFIGRHF IIGLSTVTFT LPLSLYRNIA KLGKVSLIST GLTTLILGIV MARAISLGPH 120

IPKTEDAWVF AKPNAIQAVG VMSFAFICHH NSFLVYSSLE EPTVAKWSRL IHMSIVISVF 180 ICIFFATCGY LTFTGFTQGD LFENYCRNDD LVTFGRFCYG VTVILTYPME CFVTREVIAN 240

VFFGGNLSSV FHIWTVMVI TVATLVSLLI DCLGIVLELN GVLCATPLIF IIPSACYLKL 300

SEEPRTHSDK IMSCVMLPIG AWMVFGFVM AITNTQDCTH GQEMFYCFPD NFSLTNTSES 360 HVQQTTQLST LNISIFQLE Seq ID NO: 676 DNA sequence

Nucleic Acid Accession ft: NM_006853.1 Coding sequence: 26..874

1 11 21 31 41 51 i i i I i I

AGGAATCTGC GCTCGGGTTC CGCAGATGCA GAGGTTGAGG TGGCTGCGGG ACTGGAAGTC 60

ATCGGGCAGA GGTCTCACAG CAGCCAAGGA ACCTGGGGCC CGCTCCTCCC CCCTCCAGGC 120

CATGAGGATT CTGCAGTTAA TCCTGCTTGC TCTGGCAACA GGGCTTGTAG GGGGAGAGAC 180

CAGGATCATC AAGGGGTTCG AGTGCAAGCC TCACTCCCAG CCCTGGCAGG CAGCCCTGTT 240 CGAGAAGACG CGGCTACTCT GTGGGGCGAC GCTCATCGCC CCCAGATGGC TCCTGACAGC 300

AGCCCACTGC CTCAAGCCCC GCTACATAGT TCACCTGGGG CAGCACAACC TCCAGAAGGA 360

GGAGGGCTGT GAGCAGACCC GGACAGCCAC TGAGTCCTTC CCCCACCCCG GCTTCAACAA 420

CAGCCTCCCC AACAAAGACC ACCGCAATGA CATCATGCTG GTGAAGATGG CATCGCCAGT 480

CTCCATCACC TGGGCTGTGC GACCCCTCAC CCTCTCCTCA CGCTGTGTCA CTGCTGGGAC 540 CAGCTGCCTC ATTTCCGGCT GGGGCAGCAC GTCCAGCCCC CAGTTACGCC TGCCTCACAC 600

CTTGCGATGC GCCAACATCA CCATCATTGA GCACCAGAAG TGTGAGAACG CCTACCCCGG 660

CAACATCACA GACACCATGG TGTGTGCCAG CGTGCAGGAA GGGGGCAAGG ACTCCTGCCA 720

GGGTGACTCC GGGGGCCCTC TGGTCTGTAA CCAGTCTCTT CAAGGCATTA TCTCCTGGGG 780

CCAGGATCCG TGTGCGATCA CCCGAAAGCC TGGTGTCTAC ACGAAAGTCT GCAAATATGT 840 GGACTGGATC CAGGAGACGA TGAAGAACAA TTAGACTGGA CCCACCCACC ACAGCCCATC 900

ACCCTCCATT TCCACTTGGT GTTTGGTTCC TGTTCACTCT GTTAATAAGA AACCCTAAGC 960

CAAGACCCTC TACGAACATT CTTTGGGCCT CCTGGACTAC AGGAGATGCT GTCACTTAAT 1020

AATCAACCTG GGGTTCGAAA TCAGTGAGAC CTGGATTCAA ATTCTGCCTT GAAATATTGT 1080

GACTCTGGGA ATGACAACAC CTGGTTTGTT CTCTGTTGTA TCCCCAGCCC CAAAGACAGC 1140 TCCTGGCCAT ATATCAAGGT TTCAATAAAT ATTTGCTAAA TGAGTG

Seq ID NO: 677 Protein sequence Protein Accession ft: NP__006844.1

1 . 11 21 31 41 51

I I I I I 1

MRILQLILLA LATGLVGGET RIIKGFECKP HSQPWQAALF EKTRLLCGAT LIAPRWLLTA 60 AHCLKPRYIV HLGQHNLQKE EGCEQTRTAT ESFPHPGFNN SLPNKDHRND IMLVKMASPV 120

SITWAVRPLT LSSRCVTAGT SCLISGWGST SSPQLRLPHT LRCANITIIE HQKCENAYPG 180

NITDTMVCAS VQEGGKDSCQ GDSGGPLVCN QSLQGIISWG QDPCAITRKP GVYTKVCKYV 240 DWIQETMKNN

Seq ID NO: 678 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 1..933

11 21 31 41 51

ATGTGCAGCA ATGGACGGTG CATCCCGGGC GCCTGGCAGT GTGACGGGCT GCCTGACTGC 60 TTCGACAAGA GTGATGAGAA GGAGTGCCCC AAGGCTAAGT CGAAATGTGG CCCGACCTTC 120 TTCCCCTGTG CCAGCGGCAT CCATTGCATC ATTGGTCGCT TCCGGTGCAA TGGGTTTGAG 180 GACTGTCCCG ATGGCAGCGA TGAAGAGAAC TGCACAGCAA ACCCTCTGCT TTGCTCCACC 240 GCCCGCTACC ACTGCAAGAA CGGCCTCTGT ATTGACAAGA GCTTCATCTβ CGATGGACAG 300 AATAACTGTC AAGACAACAG TGATGAGGAA AGCTGTGAAA GTTCTCAAGA ACCCGGCAGT 360 GGGCAGGTGT TTGTGACTTC AGAGAACCAA CTTGTGTATT ACCCCAGCAT CACCTATGCC 420 ATCATCGGCA GCTCCGTCAT TTTTGTGCTG GTGGTGGCCC TGCTGGCACT GGTCTTGCAC 480 CACCAGCGGA AGCGGAACAA CCTCATGACG CTGCCCGTGC ACCGGCTGCA GCACCCTGTG 540 CTGCTGTCCC GCCTGGTGGT CCTGGACCAC CCCCACCACT GCAACGTCAC CTACAACGTC 600 AATAATGGCA TCCAGTATGT GGCCAGCCAG GCGGAGCAGA ATGCGTCGGA AGTAGGCTCC 660 CCACCCTCCT ACTCCGAGGC CTTGCTGGAC CAGAGGCCTG CGTGGTATGA CCTTCCTCCA 720 CCGCCCTACT CTTCTGACAC GGAATCTCTG AACCAAGCCG ACCTGCCCCC CTACCGCTCC 780 CGGTCCGGGA GTGCCAACAG TGCCAGCTCC CAGGCAGCCA GCAGCCTCCT GAGCGTGGAA 840 GACACCAGCC ACAGCCCGGG GCAGCCTGGC CCCCAGGAGG GCACTGCTGA GCCCAGGGAC 900 TCTGAGCCCA GCCAGGGCAC TGAAGAAGTA TAA

Seq ID NO: 679 Protein sequence Protein Accession ft: Eos sequence

11 21 31 41 51

MCSNGRCIPG AWQCDGLPDC FDKSDEKECP KAKSKCGPTF FPCASGIHCI IGRFRCNGFE 60 DCPDGSDEEN CTANPLLCST ARYHCKNGLC IDKSFICDGQ NNCQDNSDEE SCESSQEPGS 120 GQVFVTSENQ LVYYPSITYA IIGSSVIFVL WALLALVLH HQRKRNNLMT LPVHRLQHPV 180 LLSRLWLDH PHHCNVTYNV NNGIQYVASQ AEQNASEVGS PPSYSEALLD QRPAWYDLPP 240 PPYSSDTESL NQADLPPYRS RSGSANSASS QAASSLLSVE DTSHSPGQPG PQEGTAEPRD 300 SEPSQGTEEV

Seq ID NO: 680 DNA sequence Nucleic Acid Accession ft: S78203.1 Coding sequence: 1..2190

11 21 31 41 51

ATGAATCCTT TCCAGAAAAA TGAGTCCAAG GAAACTCTTT TTTCACCTGT CTCCATTGAA 60 GAGGTACCAC CTCGACCACC TAGCCCTCCA AAGAAGCCAT CTCCGACAAT CTGTGGCTCC 120 AACTATCCAC TGAGCATTGC CTTCATTGTG GTGAATGAAT TCTGCGAGCG CTTTTCCTAT 180 TATGGAATGA AAGCTGTGCT GATCCTGTAT TTCCTGTATT TCCTGCACTG GAATGAAGAT 240 ACCTCCACAT CTATATACCA TGCCTTCAGC AGCCTCTGTT ATTTTACTCC CATCCTGGGA 300 GCAGCCATTG CTGACTCGTG GTTGGGAAAA TTCAAGACAA TCATGTATCT CTCCTTGGTG 360 TATGTGCTTG GCCATGTGAT CAAGTCCTTG GGTGCCTTAC CAATACTGGG AGGACAAGTG 420 GTACACACAG TCCTATCATT GATCGGCCTG AGTCTAATAG CTTTGGGGAC AGGAGGCATC 480 AAACCCTGTG TGGCAGCTTT TGGTGGAGAC CAGTTTGAAG AAAAACATGC AGAGGAACGG 540 ACTAGATACT TCTCAGTCTT CTACCTGTCC ATCAATGCAG GGAGCTTGAT TTCTACATTT 600 ATCACACCCA TGCTGAGAGG AGATGTGCAA TGTTTTGGAG AAGACTGCTA TGCATTGGCT 660 TTTGGAGTTC CAGGACTGCT CATGGTAATT GCACTTGTTG TGTTTGCAAT GGGAAGCAAA 720 ATATACAATA AACCACCCCC TGAAGGAAAC ATAGTGGCTC AAGTTTTCAA ATGTATCTGG 780 TTTGCTATTT CCAATCGTTT CAAGAACCGT TCTGGAGACA TTCCAAAGCG ACAGCACTGG 840 CTAGACTGGG CAGCTGAGAA ATATCCAAAG CAGCTCATTA TGGATGTAAA GGCACTGACC 900 AGGGTACTAT TCCTTTATAT CCCATTGCCC ATGTTCTGGG CTCTTTTGGA TCAGCAGGGT 960 TCACGATGGA CTTTGCAAGC CATCAGGATG AATAGGAATT TGGGGTTTTT TGTGCTTCAG 1020 CCGGACCAGA TGCAGGTTCT AAATCCCTTT CTGGTTCTTA TCTTCATCCC GTTGTTTGAC 1080 TTTGTCATTT ATCGTCTGGT CTCCAAGTGT GGAATTAACT TCTCATCACT TAGGAAAATG 1140 GCTGTTGGTA TGATCCTAGC GTGCCTGGCA TTTGCAGTTG CGGCAGCTGT AGAGATAAAA 1200 ATAAATGAAA TGGCCCCAGC CCAGTCAGGT CCCCAGGAGG TTTTCCTACA AGTCTTGAAT 1260 CTGGCAGATG ATGAGGTGAA GGTGACAGTG GTGGGAAATG AAAACAATTC TCTGTTGATA 1320 GAGTCCATCA AATCCTTTCA GAAAACACCA CACTATTCCA AACTGCACCT GAAAACAAAA 1380 AGCCAGGATT TTCACTTCCA CCTGAAATAT CACAATTTGT CTCTCTACAC TGAGCATTCT 1440 GTGCAGGAGA AGAACTGGTA CAGTCTTGTC ATTCGTGAAG ATGGGAACAG TATCTCCAGC 1500 ATGATGGTAA AGGATACAGA AAGCAAAACA ACCAATGGGA TGACAACCGT GAGGTTTGTT 1560 AACACTTTGC ATAAAGATGT CAACATCTCC CTGAGTACAG ATACCTCTCT CAATGTTGGT 1620 GAAGACTATG GTGTGTCTGC TTATAGAACT GTGCAAAGAG GAGAATACCC TGCAGTGCAC 1680 TGTAGAACAG AAGATAAGAA CTTTTCTCTG AATTTGGGTC TTCTAGACTT TGGTGCAGCA 1740 TATCTGTTTG TTATTACTAA TAACACCAAT CAGGGTCTTC AGGCCTGGAA GATTGAAGAC 1800 ATTCCAGCCA ACAAAATGTC CATTGCGTGG CAGCTACCAC AATATGCCCT GGTTACAGCT 1860 GGGGAGGTCA TGTTCTCTGT CACAGGTCTT GAGTTTTCTT ATTCTCAGGC TCCCTCTAGC i 20 ATGAAATCTG TGCTCCAGGC AGCTTGGCTA TTGACAATTG CAGTTGGGAA TATCATCGTG ιgβo CTTGTTGTGG CACAGTTCAG TGGCCTGGTA CAGTGGGCCG AATTCATTTT GTTTTCCTGC 2040 CTCCTGCTGG TGATCTGCCT GATCTTCTCC ATCATGGGCT ACTACTATGT TCCTGTAAAG 2100 ACAGAGGATA TGCGGGGTCC AGCAGATAAG CACATTCCTC ACATCCAGGG GAACATGATC 2160 AAACTAGAGA CCAAGAAGAC AAAACTCTGA

Seq ID NO: 681 Protein sequence Protein Accession ft: AAB34388.1 1 11 21 31 41 51

I I I I I I

MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV VNEFCERFSY 60

YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG AAIADSWLGK FKTIIYLSLV 120

YVLGHVIKSL GALPILGGQV VHTVLSLIGL SLIALGTGGI KPCVAAFGGD QFEEKHAEER 180

TRYFSVFYLS INAGSLISTF ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALWFAMGSK 240

IYNKPPPEGN IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT 300

RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPF LVLIFIPLFD 360

FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK INEMAPAQSG PQEVFLQVLN 420

LADDEVKVTV VGNENNSLLI ESIKSFQKTP HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS 480

VQEKNWYSLV IREDGNSISS MMVKDTESKT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG 540

EDYGVSAYRT VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED 600

IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL LTIAVGNIIV 660

LWAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK TEDMRGPADK HIPHIQGNMI 720 KLETKKTKL

Seq ID NO : 682 DNA sequence

Nucleic Acid Accession ft : NM_016077 . 1

Coding sequence : 128 . . 667

1 11 21 31 41 51

I I I I I I

TCGCTTTGTG ATTCTTGATC CGGAACTTTG TCACCCAGGA ACCCCGGAAG AGGTAGCTCA 60

CGCGATAGAA ACGTGTTCGC TTGCCCAGAA GAAGGGAAGG CGCGAGTGAG GAAAGGAGGT 120

ACTGTAGATG CCCTCCAAAT CCTTGGTTAT GGAATATTTG GCTCATCCCA GTACACTCGG 180

CTTGGCTGTT GGAGTTGCTT GTGGCATGTG CCTGGGCTGG AGCCTTCGAG TATGCTTTGG 240

GATGCTCCCC AAAAGCAAGA CGAGCAAGAC ACACACAGAT ACTGAAAGTG AAGCAAGCAT 300

CTTGGGAGAC AGCGGGGAGT ACAAGATGAT TCTTGTGGTT CGAAATGACT TAAAGATGGG 360

AAAAGGGAAA GTGGCTGCCC AGTGCTCTCA TGCTGCTGTT TCAGCCTACA AGCAGATTCA 420

AAGAAGAAAT CCTGAAATGC TCAAACAATG GGAATACTGT GGCCAGCCCA AGGTGGTGGT 480

CAAAGCTCCT GATGAAGAAA CCCTGATTGC ATTATTGGCC CATGCAAAAA TGCTGGGACT 540

GACTGTAAGT TTAATTCAAG ATGCTGGACG TACTCAGATT GCACCAGGCT CTGAAACTGT 600

CCTAGGGATT GGGCCAGGAC CAGCAGACCT AATTGACAAA GTCACTGGTC ACCTAAAACT 660

TTACTAGGTG GACTTTGATA TGACAACAAC CCCTCCATCA CAAGTGTTTG AAGCCTGTCA 720

GATTCTAACA ACAAAAGCTG AATTTCTTCA CCCAACTTAA ATGTTCTTGA GATGAAAATA 780 AAACCTATTC CCATGTTCTA AAAAAA

Seq ID NO: 683 Protein sequence Protein Accession ft: NP_057161.1

1 11 21 31 41 51

1 I I I I I

MPSKSLVMEY LAHPSTLGLA VGVACGMCLG WSLRVCFGML PKSKTSKTHT DTESEASILG 60

DSGEYKMILV VRNDLKMGKG KVAAQCSHAA VSAYKQIQRR NPEMLKQWEY CGQPKVWKA 120 PDEETLIALL AHAKMLGLTV SLIQDAGRTQ IAPGSQTVLG IGPGPADLID KVTGHLKLY

Seq ID NO: 684 DNA sequence

Nucleic Acid Accession ft: NM_004864.1

Coding sequence: 26..952

1 11 21 31 41 51

I I I 1 I I

CGGAACGAGG GCAACCTGCA CAGCCATGCC CGGGCAAGAA CTCAGGACGG TGAATGGCTC 60

TCAGATGCTC CTGGTGTTGC TGGTGCTCTC GTGGCTGCCG CATGGGGGCG CCCTGTCTCT 120

GGCCGAGGCG AGCCGCGCAA GTTTCCCGGG ACCCTCAGAG TTGCACTCCG AAGACTCCAG 180

ATTCCGAGAG TTGCGGAAAC GCTACGAGGA CCTGCTAACC AGGCTGCGGG CCAACCAGAG 2 0

CTGGGAAGAT TCGAACACCG ACCTCGTCCC GGCCCCTGCA GTCCGGATAC TCACGCCAGA 300

AGTGCGGCTG GGATCCGGCG GCCACCTGCA CCTGCGTATC TCTCGGGCCG CCCTTCCCGA 360

GGGGCTCCCC GAGGCCTCCC GCCTTCACCG GGCTCTGTTC CGGCTGTCCC CGACGGCGTC 420

AAGGTCGTGG GACGTGACAC GACCGCTGCG GCGTCAGCTC AGCCTTGCAA GACCCCAAGC 480

GCCCGCGCTG CACCTGCGAC TGTCGCCGCC GCCGTCGCAG TCGGACCAAC TGCTGGGAGA 540

ATCTTCGTCC GCACGGCCCC AGCTGGAGTT GCACTTGCGG CCGCAAGCCG CCAGGGGGCG 600

CCGCAGAGCG CGTGCGCGCA ACGGGGACGA CTGTCCGCTC GGGCCCGGGC GTTGCTGCCG 660

TCTGCACACG GTCCGCGCGT CGCTGGAAGA CCTGGGCTGG GCCGATTGGG TGCTGTCGCC 720

ACGGGAGGTG CAAGTGACCA TGTGCATCGG CGCGTGCCCG AGCCAGTTCC GGGCGGCAAA 780

CATGCACGCG CAGATCAAGA CGAGCCTGCA CCGCCTGAAG CCCGACACGG AGCCAGCGCC 840

CTGCTGCGTG CCCGCCAGCT ACAATCCCAT GGTGCTCATT CAAAAGACCG ACACCGGGGT 900

GTCGCTCCAG ACCTATGATG ACTTGTTAGC CAAAGACTGC CACTGCATAT GAGCAGTCCT 960

GGTCCTTCCA CTGTGCACCT GCGCGGGGGA GGCGACCTCA GTTGTCCTGC CCTGTGGAAT 1020

GGGCTCAAGG TTCCTGAGAC ACCCGATTCC TGCCCAAACA GCTGTATTTA TATAAGTCTG 1080

TTATTTATTA TTAATTTATT GGGGTGACCT TCTTGGGGAC TCGGGGGCTG GTCTGATGGA 1140

ACTGTGTATT TATTTAAAAC TCTGGTGATA AAAATAAAGC TGTCTGAACT GTTAAAAAAA 1200 AAAA Seq ID NO: 685 Protein sequence Protein Accession ft: NP 004855.1

1 11 21 31 41 51

I I I I I I

MPGQELRTVN GSQMLLVLLV LSWLPHGGAL SLAEASRASF PGPSELHSED SRFRELRKRY 60

EDLLTRLRAN QSWEDSNTDL VPAPAVRILT PEVRLGSGGH LHLRISRAAL PEGLPEASRL 120

HRALFRLSPT ASRSWDVTRP LRRQLSLARP QAPALHLRLS PPPSQSDQLL AESSSARPQL 180

ELHLRPQAAR GRRRARARNG DDCPLGPGRC CRLHTVRASL EDLGWADWVL SPREVQVTMC 240

IGACPSQFRA ANMHAQIKTS LHRLKPDTEP APCCVPASYN PMVLIQKTDT GVSLQTYDDL 300 LAKDCHCI

Seq ID NO: 686 DNA sequence Nucleic Acid Accession ft: NM_002423.2 Coding sequence: 48..851

1 11 21 31 41 51

I I I I I I

ACCAAATCAA CCATAGGTCC AAGAACAATT GTCTCTGGAC GGCAGCTATG CGACTCACCG 60

TGCTGTGTGC TGTGTGCCTG CTGCCTGGCA GCCTGGCCCT GCCGCTGCCT CAGGAGGCGG 120

GAGGCATGAG TGAGCTACAG TGGGAACAGG CTCAGGACTA TCTCAAGAGA TTTTATCTCT 180

ATGACTCAGA AAGAAAAAAT GCCAACAGTT TAGAAGCCAA ACTCAAGGAG ATGCAAAAAT 240

TCTTTGGCCT ACCTATAACT GGAATGTTAA ACTCCCGCGT CATAGAAATA ATGCAGAAGC 300

CCAGATGTGG AGTGCCAGAT GTTGCAGAAT ACTCACTATT TCCAAATAGC CCAAAATGGA 360

CTTCCAAAGT GGTCACCTAC AGGATCGTAT CATATACTCG AGACTTACCG CATATTACAG 420

TGGATCGATT AGTGTCAAAG GCTTTAAACA TGTGGGGCAA AGAGATCCCC CTGCATTTCA 480

GGAAAGTTGT ATGGGGAACT GCTGACATCA TGATTGGCTT TGCGCGAGGA GCTCATGGGG 540

ACTCCTACCC ATTTGATGGG CCAGGAAACA CGCTGGCTCA TGCCTTTGCG CCTGGGACAG 600

GTCTCGGAGG AGATGCTCAC TTCGATGAGG ATGAACGCTG GACGGATGGT AGCAGTCTAG 660

GGATTAACTT CCTGTATGCT GCAACTCATG AACTTGGCCA TTCTTTGGGT ATGGGACATT 720

CCTCTGATCC TAATGCAGTG ATGTATCCAA CCTATGGAAA TGGAGATCCC CAAAATTTTA 780

AACTTTCCCA GGATGATATT AAAGGCATTC AGAAACTATA TGGAAAGAGA AGTAATTCAA 840

GAAAGAAATA GAAACTTCAG GCAGAACATG CATTCATTCA TTCATTGGAT TGTATATCAT 900

TGTTGCACAA TCAGAATTGA TAAGCACTGT TCCTCCACTC CATTTAGCAA TTATGTGACC 960

CTTTTTTATT GCAGTTGGTT TTTGAATGTC TTTCACTCCT TTTATTGGTT AAACTCCTTT 1020

ATGGTGTGAC TGTGTCTTAT TCCATCTATG AGCTTTGTCA GTGCGCGTAG ATGTCAATAA 1080 ATGTTACATA CACAAATAAA TAAAATGTTT ATTCCATGGT AAATTTA

Seq ID NO: 687 Protein sequence Protein Accession ft: NP 002414.1

1 11 21 31 41 51 i i i i i i

MRLTVLCAVC LLPGSLALPL PQEAGGMSEL QWEQAQDYLK RFYLYDSETK NANSLEAKLK 60

EMQKFFGLPI TGMLNSRVIE IMQKPRCGVP DVAEYSLFPN SPKWTSKWT YRIVSYTRDL 120

PHITVDRLVS KALNMWGKEI PLHFRKWWG TADIMIGFAR GAHGDSYPFD GPGNTLAHAF 180

APGTGLGGDA HFDEDERWTD GSSLGINFLY AATHELGHSL GMGHSSDPNA VMYPTYGNGD 240 PQNFKLSQDD IKGIQKLYGK RSNSRKK

Seq ID NO: 688 DNA sequence

Nucleic Acid Accession ft: NM_005221.3

Coding sequence: 1..870

1 11 21 31 41 51

I I I I I I

ATGACAGGAG TGTTTGACAG AAGGGTCCCC AGCATCCGAT CCGGCGACTT CCAAGCTCCG 60

TTCCAGACGT CCGCAGCTAT GCACCATCCG TCTCAGGAAT CGCCAACTTT GCCCGAGTCT 120

TCAGCTACCG ATTCTGACTA CTACAGCCCT ACGGGGGGAG CCCCGCACGG CTACTGCTCT 180

CCTACCTCGG CTTCCTATGG CAAAGCTCTC AACCCCTACC AGTATCAGTA TCACGGCGTG 240

AACGGCTCCG CCGGGAGCTA CCCAGCCAAA GCTTATGCCG ACTATAGCTA CGCTAGCTCC 300

TACCACCAGT ACGGCGGCGC CTACAACCGC GTCCCAAGCG CCACCAACCA GCCAGAGAAA 360

GAAGTGACCG AGCCCGAGGT GAGAATGGTG AATGGCAAAC CAAAGAAAGT TCGTAAACCC 420

AGGACTATTT ATTCCAGCTT TCAGCTGGCC GCATTACAGA GAAGGTTTCA GAAGACTCAG 480

TACCTCGCCT TGCCGGAACG CGCCGAGCTG GCCGCCTCGC TGGGATTGAC ACAAACACAG 540

GTGAAAATCT GGTTTCAGAA CAAAAGATCC AAGATCAAGA AGATCATGAA AAACGGGGAG 600

ATGCCCCCGG AGCACAGTCC CAGCTCCAGC GACCCAATGG CGTGTAACTC GCCGCAGTCT 660

CCAGCGGTGT GGGAGCCCCA GGGCTCGTCC CGCTCGCTCA GCCACCACCC TCATGCCCAC 720

CCTCCGACCT CCAACCAGTC CCCAGCGTCC AGCTACCTGG AGAACTCTGC ATCCTGGTAC 780

ACAAGTGCAG CCAGCTCAAT CAATTCCCAC CTGCCGCCGC CGGGCTCCTT ACAGCACCCG 840 CTGGCGCTGG CCTCCGGGAC ACTCTATTAG

Seq ID NO: 689 Protein sequence Protein Accession ft: NP_005212.1

1 11 21 31 41 51

I I I I I I

MTGVFDRRVP SIRSGDFQAP FQTSAAMHHP SQESPTLPES SATDSDYYSP TGGAPHGYCS 60 PTSASYGKAL NPYQYQYHGV NGSAGSYPAK AYADYSYASS YHQYGGAYNR VPSATNQPEK 120

EVTEPEVRMV NGKPKKVRKP RTIYSSFQLA ALQRRFQKTQ YLALPERAEL AASLGLTQTQ 180

VKIWFQNKRS KIKKIMKNGE MPPEHSPSSS DPMACNSPQS PAVWEPQGSS RSLSHHPHAH 240 PPTSNQSPAS SYLENSASWY TSAASSINSH LPPPGSLQHP LALASGTLY

It is understood that the examples described above in no way serve to limit the true scope of this invention, but rather are presented for illustrative purposes. All publications, sequences of accession numbers, and patent applications cited in this specification are herein ncorporated by reference as if each individual publication or patent application were specifically and individually indicated to be incoφorated by reference.

Claims

WHAT IS CLAIMED IS: L A method of detecting a lung cancer-associated transcript in a cell from a patient, the method comprising contacting a biological sample from the patient with a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1A-16.

2. The method of claim 1, wherein the polynucleotide selectively hybridizes to a sequence at least 95% identical to a sequence as shown in Tables 1A-16.

3. The method of claim 1 , wherein the biological sample is a tissue sample.

4. The method of claim 1 , wherein the biological sample comprises isolated nucleic acids.

5. The method of claim 4, wherein the nucleic acids are mRNA.

6. The method of claim 4, further comprising the step of amplifying nucleic acids before the step of contacting the biological sample with the polynucleotide.

7. The method of claim 1 , wherein the polynucleotide comprises a sequence as shown in Tables 1 A-16.

8. The method of claim 1, wherein the polynucleotide is labeled.

9. The method of claim 8, wherein the label is a fluorescent label.

10. The method of claim 1 , wherein the polynucleotide is immobilized on a solid surface.

11. The method of claim 1 , wherein the patient is undergoing a therapeutic regimen to treat lung cancer.

12. The method of claim 1 , wherein the patient is suspected of having lung cancer.

13. A method of monitoring the efficacy of a therapeutic treatment of lung cancer, the method comprising the steps of: (i) providing a biological sample from a patient undergoing the therapeutic treatment; and (ii) determining the level of a lung cancer-associated transcript in the biological sample by contacting the biological sample with a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1 A-16, thereby monitoring the efficacy ofthe therapy.

14. The method of claim 13, further comprising the step of: (iii) comparing the level ofthe lung cancer-associated transcript to a level ofthe lung cancer-associated transcript in a biological sample from the patient prior to, or earlier in, the therapeutic treatment.

15. The method of claim 13 , wherein the patient is a human.

16. A method of monitoring the efficacy of a therapeutic treatment of lung cancer, the method comprising the steps of: (i) providing a biological sample from a patient undergoing the therapeutic treatment; and (ii) determining the level of a lung cancer-associated antibody in the biological sample by contacting the biological sample with a polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1 A-16, wherein the polypeptide specifically binds to the lung cancer-associated antibody, thereby monitoring the efficacy ofthe therapy.

17. The method of claim 16, further comprising the step of: (iii) comparing the level ofthe lung cancer-associated antibody to a level ofthe lung cancer-associated antibody in a biological sample from the patient prior to, or earlier in, the therapeutic treatment.

18. The method of claim 16, wherein the patient is a human.

19. A method of monitoring the efficacy of a therapeutic treatment of lung cancer, the method comprising the steps of: (i) providing a biological sample from a patient undergoing the therapeutic treatment; and (ii) determining the level of a lung cancer-associated polypeptide in the biological sample by contacting the biological sample with an antibody, wherein the antibody specifically binds to a polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1A-16, thereby monitoring the efficacy ofthe therapy.

20. The method of claim 19, further comprising the step of: (iii) comparing the level ofthe lung cancer-associated polypeptide to a level ofthe lung cancer-associated polypeptide in a biological sample from the patient prior to, or earlier in, the therapeutic treatment.

21. The method of claim 19, wherein the patient is a human.

22. An isolated nucleic acid molecule consisting of a polynucleotide sequence as shown in Tables 1A-16.

23. The nucleic acid molecule of claim 22, which is labeled.

24. The nucleic acid of claim 23, wherein the label is a fluorescent label

25. An expression vector comprising the nucleic acid of claim 22.

26. A host cell comprising the expression vector of claim 25.

27. An isolated polypeptide which is encoded by a nucleic acid molecule having polynucleotide sequence as shown in Tables 1 A-l 6.

28. An antibody that specifically binds a polypeptide of claim 27.

29. The antibody of claim 28, further conjugated to an effector component.

30. The antibody of claim 29, wherein the effector component is a fluorescent label.

31. The antibody of claim 29, wherein the effector component is a radioisotope or a cytotoxic chemical.

32. The antibody of claim 29, which is an antibody fragment.

33. The antibody of claim 29, which is a humanized antibody

34. A method of detecting a lung cancer cell in a biological sample from a patient, the method comprising contacting the biological sample with an antibody of claim 28.

35. The method of claim 34, wherein the antibody is further conjugated to an effector component.

36. The method of claim 35, wherein the effector component is a fluorescent label.

37. A method of detecting antibodies specific to lung cancer in a patient, the method comprising contacting a biological sample from the patient with a polypeptide encoded by a nucleic acid comprises a sequence from Tables 1A-16.

38. A method for identifying a compound that modulates a lung cancer- associated polypeptide, the method comprising the steps of: (i) contacting the compound with a lung cancer-associated polypeptide, the polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1A-16; and (ii) determining the functional effect ofthe compound upon the polypeptide.

39. The method of claim 38, wherein the functional effect is a physical effect. ^'

40. The method of claim 38, wherein the functional effect is a chemical effect.

41. The method of claim 38, wherein the polypeptide is expressed in a eukaryotic host cell or cell membrane.

42. The method of claim 38, wherein the functional effect is determined by measuring ligand binding to the polypeptide.

43. The method of claim 38, wherein the polypeptide is recombinant.

44. A method of inhibiting proliferation of a lung cancer-associated cell to treat lung cancer in a patient, the method comprising the step of administering to the subject a therapeutically effective amount of a compound identified using the method of claim 38.

45. The method of claim 44, wherein the compound is an antibody.

46. The method of claim 45, wherein the patient is a human.

47. A drug screening assay comprising the steps of (i) administering a test compound to a mammal having lung cancer or a cell isolated therefrom; (ii) comparing the level of gene expression of a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1 A- 16 in a treated cell or mammal with the level of gene expression ofthe polynucleotide in a control cell or mammal, wherein a test compound that modulates the level of expression of the polynucleotide is a candidate for the treatment of lung cancer.

48. The assay of claim 47, wherein the control is a mammal with lung cancer or a cell therefrom that has not been treated with the test compound.

49. The assay of claim 47, wherein the control is a normal cell or mammal.

50. A method for treating a mammal having lung cancer comprising administering a compound identified by the assay of claim 47.

51. A pharmaceutiPcal composition for treating a mammal having lung cancer, the composition comprising a compound identified by the assay of claim 47 and a physiologically acceptable excipient.