WO2002082928A1 - Health foods supplementary for treatment and prevention of constipation - Google Patents
Health foods supplementary for treatment and prevention of constipation Download PDFInfo
- Publication number
- WO2002082928A1 WO2002082928A1 PCT/KR2001/001611 KR0101611W WO02082928A1 WO 2002082928 A1 WO2002082928 A1 WO 2002082928A1 KR 0101611 W KR0101611 W KR 0101611W WO 02082928 A1 WO02082928 A1 WO 02082928A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- constipation
- auricularia auricula
- food
- health supplementary
- rats
- Prior art date
Links
- 206010010774 Constipation Diseases 0.000 title claims abstract description 45
- 230000002265 prevention Effects 0.000 title abstract description 7
- 235000013402 health food Nutrition 0.000 title description 2
- 235000013305 food Nutrition 0.000 claims abstract description 41
- 230000036541 health Effects 0.000 claims abstract description 28
- 235000000023 Auricularia auricula Nutrition 0.000 claims description 36
- 239000010369 Cascara Substances 0.000 claims description 31
- 241000556215 Frangula purshiana Species 0.000 claims description 31
- 229940071704 cascara sagrada Drugs 0.000 claims description 29
- 239000000843 powder Substances 0.000 claims description 14
- 240000000249 Morus alba Species 0.000 claims description 13
- 235000008708 Morus alba Nutrition 0.000 claims description 13
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 9
- 239000000347 magnesium hydroxide Substances 0.000 claims description 9
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 9
- 239000004615 ingredient Substances 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 3
- 241001149430 Auricularia auricula-judae Species 0.000 claims 4
- 210000003608 fece Anatomy 0.000 abstract description 15
- 241000221377 Auricularia Species 0.000 abstract description 6
- 230000004936 stimulating effect Effects 0.000 abstract description 3
- 244000028550 Auricularia auricula Species 0.000 description 32
- 241000700159 Rattus Species 0.000 description 28
- 239000000203 mixture Substances 0.000 description 20
- 230000002550 fecal effect Effects 0.000 description 14
- 239000000835 fiber Substances 0.000 description 11
- 235000012631 food intake Nutrition 0.000 description 9
- 230000037406 food intake Effects 0.000 description 9
- 239000008187 granular material Substances 0.000 description 8
- 241001088162 Primula auricula Species 0.000 description 7
- 235000006894 Primula auricula Nutrition 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 230000008859 change Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 210000000936 intestine Anatomy 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000029142 excretion Effects 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 210000002429 large intestine Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000008141 laxative Substances 0.000 description 3
- RDOIQAHITMMDAJ-UHFFFAOYSA-N loperamide Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)N(C)C)CCN(CC1)CCC1(O)C1=CC=C(Cl)C=C1 RDOIQAHITMMDAJ-UHFFFAOYSA-N 0.000 description 3
- 229960001571 loperamide Drugs 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000013222 sprague-dawley male rat Methods 0.000 description 3
- 239000000021 stimulant Substances 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241000219061 Rheum Species 0.000 description 2
- 244000299790 Rheum rhabarbarum Species 0.000 description 2
- 235000009411 Rheum rhabarbarum Nutrition 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 229940058505 cascara Drugs 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 235000013325 dietary fiber Nutrition 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- -1 hydrogen- Chemical class 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000002475 laxative effect Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 230000008855 peristalsis Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010000117 Abnormal behaviour Diseases 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 244000275701 Geranium nepalense Species 0.000 description 1
- 244000241872 Lycium chinense Species 0.000 description 1
- 235000015468 Lycium chinense Nutrition 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 244000134552 Plantago ovata Species 0.000 description 1
- 235000003421 Plantago ovata Nutrition 0.000 description 1
- 241000092659 Pleuropterus Species 0.000 description 1
- 244000292697 Polygonum aviculare Species 0.000 description 1
- 235000006386 Polygonum aviculare Nutrition 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000009223 Psyllium Substances 0.000 description 1
- 208000015634 Rectal Neoplasms Diseases 0.000 description 1
- 241000801924 Sena Species 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 235000007244 Zea mays Nutrition 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- RHZUVFJBSILHOK-UHFFFAOYSA-N anthracen-1-ylmethanolate Chemical compound C1=CC=C2C=C3C(C[O-])=CC=CC3=CC2=C1 RHZUVFJBSILHOK-UHFFFAOYSA-N 0.000 description 1
- 239000003830 anthracite Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229940075397 calomel Drugs 0.000 description 1
- KDRIEERWEFJUSB-UHFFFAOYSA-N carbon dioxide;methane Chemical compound C.O=C=O KDRIEERWEFJUSB-UHFFFAOYSA-N 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000018823 dietary intake Nutrition 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229940099198 dulcolax Drugs 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 239000004137 magnesium phosphate Substances 0.000 description 1
- 229960002261 magnesium phosphate Drugs 0.000 description 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 1
- 235000010994 magnesium phosphates Nutrition 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229940070687 psyllium Drugs 0.000 description 1
- 230000001543 purgative effect Effects 0.000 description 1
- 206010038038 rectal cancer Diseases 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 201000001275 rectum cancer Diseases 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/14—Yeasts or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
Abstract
The present invention relates to a health supplementary food for improving constipation, more particularly, health supplementary food containing Auricularia auriacula, which is effective in prevention and treatment of constipation by loosening the bowels and stimulating bowel movements. Continuous intake of the health supplementary food according to he present invention increases the amount of feces and stimulates the bowel movements. Accordingly, it is effective in prevention and treatment of constipation.
Description
Health foods supplementary for treatment and prevention of
constipation
TECHNICAL FIETD
The present invention relates to health supplementary food for improving
constipation, more particularly, health supplementary food containing Auricularia
auricula, which is effective in prevention and treatment of constipation by loosening the
bowels and stimulating bowel movements.
BACKGROUND OF THE INVENTION
Constipation is a symptom that stool is very hard and dry compared with normal
condition, and the frequency of bowel movements and amount of feces are decreased,
thereby causing discomfort and physiological disorder. Most of constipation is habit-
forming constipation. It is divided to hypertonic- and hypotonic constipation, depending
on a symptom. In case of the hypotonic constipation, strain of large intestines weakens
and the bowel movements come to slow. Accordingly, fecal moisture content is
decreased, being dull to a reflex of the bowel movements. While, in case of the
hypertonic constipation, peristalsis in large intestines accelerates and a spasm in intestinal
wall occurs, so that stools in form of small lumps or stick that is as thick as a pencil may
be excreted. Constipation may be caused by temporary factors related to changes in
enviroriment and diet during travel, etc. In addition, constipation may be caused by
rectal cancer, rectal stricture, lesion around the rectum, chronic colitis, or acute illness in
digestive system.
Meanwhile, when fibers lack in dietary intake, feces may be tightened in weight,
leading readily to constipation. However, if a lot of fibers are included in diet, enough
moisture may be absorbed into intestines. Accordingly, feces increase in amount, which
promotes the bowel movements. As above-mentioned, fibers stimulate the intestines.
Besides, since the fibers have a lot of moisture, stools are not hard, leading to loosen the
bowels. Moreover, carcinogens, cholesterol, and many other toxic substances in the
intestines are absorbed into fibers and promptly discharged from human body. Intestinal
bacteria decompose fibers in diet, to generate hydrogen-, methane- and carbon dioxide gas,
etc. The gases strengthen stimulation into the intestines, thereby activating peristalsis in
the intestines. Therefore, the simplest and easiest method for prevention and treatment
of constipation is to take foods with enough fibers suitably.
The other method for treatment of constipation is to make an effort to have
regular bowel movements in every morning and to eat cold water or carbonated water, or
to take moderate exercise in early morning.
hi addition, laxatives such as magnesium phosphate, fenobarin, sena, Rhubarb
(Rheum unduiatum) and the like may be used as a drug. As occasion demands, an
enema may be given.
Recently, researches have been carried out on foods to improve constipation
using various kinds of natural foods or natural medicines in order to prevent constipation.
Korean Patent No. 15879 disclosed a tea too improve constipation using natural
medicines such as alvae Semen, Pleuropterus multfloiiis, Geranium nepalense subsp.
Thunbergii, fig tree, Polygonum aviculare, rhubarb (Rheum unduiatum), etc. Besides,
Korean Patent No. 32660 disclosed a drug to treat constipation using Lycium chinense
MILL, and maize (Zea mays L.) However, the drug for treating constipation that can be
utilized as food, has been not yet met the requirements. For that reason, the development
of food for preventing and treating constipation has been necessary urgently.
Therefore, the present inventors have studied on studied on food that is effective
in constipation using natural foods. As a result, the present inventors completed the
present invention by manufacturing health supplementary food that is effective in
improving constipation with an Auricularia auricula rich in fibers and natural gelatins,
and a laxative such as a cascara sagrada The said health supplementary food can
increase fecal excretion and stimulate bowel movement by the two ingredients,
Auricularia auricula and the laxative, respectively.
DISCLOSURE OF THE INVENTION
The purpose of the present invention is to provide health supplementary food that
is effective in improving constipation by increasing fecal excretion and stimulating the
bowel movements.
To accomplish this purpose, the present invention provides health supplementary
food for improving constipation containing Auricularia auricula as an active ingredient.
In addition, the health supplementary food for improving constipation according
to the present invention further may include cascara sagrada, and a powder of mulberry
leaves or magnesium hydroxide.
All amounts in this specification are % by weight (w/w) of the health
supplementary food, unless otherwise noted
Hereinafter, the present invention will be described in detail.
The health supplementary food according to the present invention contains
Auricularia auricula rich in fibers as an active component.
In Auricularia auricula, natural gelatins as well as the above fibers are also
plentiful. Therefore, in the presence of exposure to water, Auricularia auricula swells
and its volume increases 5-6 times. By this property of Auricularia auricula, fecal
excretion may be increased, accordingly, Auricularia auricula may have an effect on
improvement of constipation
Furthermore, the health supplementary food according to the present invention
may include the following ingredients as a bowel-stimulator together with Auricularia
auricula: lubricants such as mineral oil and olive oil; bulk forming agents such as
psyllium and aloe; the small intestine-stimulants such as castor oil and calomel; and the
large intestine-stimulants such as cascara sagrada, dulcolax and bicogreen, etc. However,
the lubricants can cause disorder of nutrient-adsorption with prolonged daily use and the
bulk forming agent should be taken with water. Therefore, it is desirable to use cascara
saqrada as the stimulants. It was known that cascara sagrada, a derivative of hydroxy
anthracite, acts on the large intestines to stimulate the bowel movements and on the nerve
through a blood vessel to facilitate purgative effects.
Where the cascara sagrada is added into Auricularia auricula, it is preferable that
the cascara sagrada and Auricularia auricula are present in the range of 10-40% and 60-
90% by weight, respectively. If the amount of Auricularia auricula exceeds 90% by
weight, it raises discomfort such as abdominal distention caused by the excessive intake.
While, if it is below 60% by weight, it has a little effect on an improvement of
constipation caused by the insufficient amount. Therefore, it is desirable that the amount
of Auricularia auricula is in the above-mentioned range.
The cascara sagrada is resolved in the intestinal tract, and then stimulates a
mucous membrane of the intestines to cause vermiculation, thereby loosening the bowels.
However, if its amount exceeds 40% by weight, it stimulates the large intestines to undue
extent, thereby causing diarrhea and stomachache. Therefore, it is preferable that the
amount of the cascara sagrada covers above-mentioned range.
Meanwhile, the health supplementary food containing Auricularia auricula
according to the present invention may further include a powder of mulberry leaves as
well as the cascara sagrada According to the reports, the powder of mulberry leaves
abounds in minerals such calcium, iron, etc. and dietary fibers. It has been investigated
that the dietary fibers are present in green tea in amount of 10.6%, whereas in the powder
of mulberry leaves in amount of 52.9%. Preferably, the health supplementary food may
further include the powder of mulberry leaves, particularly, in amount of 10-30% by
weight.
hi addition, the health supplementary food containing Auricularia auricula
according to the present invention may further include saline agents such as magnesium
sulfate, magnesium carbonate, magnesium hydroxide, etc., as well as the cascara sagrada.
The saline agents prevent moistures from being absorbed into the bowel wall, causing
diarrhea. Particularly, it is preferable that the amount of magnesium hydroxide is present
in the range of 5-15% by weight. If the magnesium hydroxide exceeds 15% by weight,
it may cause diarrhea Therefore, it is preferable that the amount of the magnesium
hydroxide covers the above range.
The health supplementary food containing Auricularia auricula according to the
present invention may be manufactured in the form of liquid, powder or granule, more
preferably, granule, to sell. A concrete manufacturing process comprises the following
steps: selection of materials; mixing of materials; production of granules; drying; and
packing.
First, each material of the standard quality is selected and mixed in together
according to the common method known to the present art. Ingredients generally
required for formation of granule, for example, water, alcohol and crystal cellulose, are
added to the above mixture of materials, thereby producing granules. The produced
granules are dried in the airtight dryer. It is preferable that granules are dried at 35-45 °C
for l-2hrs. Particularly, granules are airtightly wrapped in fourfold papers to sell. The
health supplementary food produced in this manner may be taken anywhere easily and
conveniently. The health supplementary food also has an advantage of facility in
keeping.
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, the present invention is more specifically illustrated by the following
examples.
However, it should be understood that these examples are provided only for
illustration of the present invention, but not intended to limit the present invention in any
manner.
<Example 1>
hi order to corrfirm the effect of Auricularia auricula on constipation, in v 'o
assay was performed with 8-weeks old Sprague-Dawley male rats.
First, in order to induce constipation, 14 rats were fed with a inhibitor of bowel
movements, loperamide(1.5nig kg, Sigma) diluted in 0.9% saline solution at AM 9:00
and PM 6:00, twice daily for 5 days, to inhibit evacuation. The constipation-induced rats
were then fed with a 20mg of Auricularia auricula extract at AM 9:00 and PM 6:00,
twice daily for 5 days.
During the experimental period, 5 days, food intake in each rat was measured
daily. At 3 day and 5 day after feeding, body weight of each rat was measured.
Results are shown in tables 1 and 2, respectively. E)uring the experimental period, all
feces excreted from each rat were also daily collected in polystyrene tube at AM 9:00 and
lyophilized to measure a dry weight. Feces excreted from rats at AM 9:00 at 2, 4 and 5
day after feeding were put in micro tube, and then weight of moisture-contained feces and
lyophilized feces were measured respectively. Fecal moisture content was measured by
calculating the difference of weights in the two forms of feces. Results are shown in
table 3.
<Example 2>
3g of Auricularia auricula and 1.5g of cascara sagrada were mixed to prepare a
composition. 20 mg of the composition was fed to 14 constipation-induced rats,
respectively. Except this, food intake, change in weight, amount of feces and fecal
moisture content were measured as described in Example 1. Results are shown in tables
1 to 3, respectively. The prepared composition included 66.6% of Auricularia auricula
and 33.4% of cascara sagrada
<Example 3>
4.875g of Auricularia auricula, 1.5g of cascara sagrada and 1.125g of powder of
mulberry leaves were mixed to prepared a composition. 20mg of the composition was
fed to 14 rats having constipation induced by loperamide. Except this, food intake,
change in weight, amount of feces and fecal moisture content were measured as described
in Example 1. Results are shown in tables 1 to 3, respectively. The prepared
composition included 65% of Auricularia auricula, 20% of cascara sagrada and 15% of
powder of mulberry leaves.
<Example 4>
4.875g of Auricularia auricula, 1.5g of cascara sagrada and 1.125g of
magnesium hydroxide were mixed to prepared a composition 20mg of the composition
was fed to 14 rats having constipation induced by loperarnide. Except this, food intake,
change in weight, amount of feces and fecal moisture content were measured as described
in Example 1. Results are shown in tables 1 to 3, respectively. The prepared
composition included 65% of Auricularia auricula, 20% of cascara sagrada and 15% of
magnesium hydroxide.
<Comparative Example 1>
8-week old Sprague-Dawley male rats were fed with only 0.9% saline solution.
Rats to the number of 14 were used in this experiment. Food intake, change in weight,
amount of feces and fecal moisture content were measured as described in Example 1.
Results are shown in tables 1 to 3, respectively.
<Comparative Example 2>
8-week old Sprague-Dawley male rats were fed with loperarnide. Rats to the
number of 14 were used in this experiment. Food intake, change in weight, fecal
excretion and fecal moisture content were measured as described in Example 1. Results
are shown in tables 1 to 3, respectively.
[Table 1]
Measurement of food intake
As shown in table 1, food intake was decreased in rats of Comparative Example 2
that had not been given any treatment after induction of constipation, compared with in
rats of Comparative Example 1, control. Whereas, it was not almost changed in rats of
Example 1 that were fed wimAuricularia auricula extract. In addition, in rats of Example
2 that were fed with the composition of Auricularia auricula and cascara sagrada, rats of
Example 3 that were fed with the composition of Auricularia awicula, cascara sagrada
and powder of mulberry leaves, and rats of Example 4 that were fed with the composition
of 'Auricularia auricula, cascara sagrada and magnesium hydroxide, food intake was not
changed during the experimental period.
[Table 2]
Measure of change in body weight
As shown in Table 2, body weight was decreased in rats of Comparative Example
2 that had not been given any treatment after induction of constipation, compared with in
rats of Comparative Example 1, control. Whereas, it was not almost changed in rats of
Example 1 that had been fed wϋhAuricularia auricula extract In rats of Example 2 that
had been fed with the composition of Auricularia auricula and cascara sagrada, rats of
Example 3 that had been fed with the composition of Auricularia auricula, cascara
sagrada and powder of mulberry leaves was fed, and rats of Example 4 that we had been
fed with the composition of Auricularia auricula, cascara sagrada and magnesium
hydroxide, body weight was not changed.
[Table 3]
Effect of each composition on constipation
As shown in Table 3, an amount of feces was remarkably increased in rats of
Example 1 that had been fed with Auricularia auricula after induction of constipation
with loperamide, compared with in rats of Comparative Example 2 that had not been
given any treatment aftα induction of constipation. Fecal moisture content was also
increased, hi addition, the amount of feces and fecal moisture content was increased in
rats of Example 2 that had been fed with the composition of Auricularia auricula and
cascara sagrada, rats of Example 3 that had been fed with the composition of Auricularia
auricula, cascara sagrada and powder of mulberry leaves, and rats of Example 4 that had
been fed with the composition of Awicularia auricula, cascara sagrada and magnesium
hydroxide.
From the results of in vivo experiments, it was corrfirmed that Auricularia
auricula extract according to the present invention has an excellent effect on constipation-
improvement hi addition, it was corrfirmed that the effect of constipation-improvement
was increased when cascara sagrada and powder of mulberry leaves were further added to
Auricularia auricula extract.
INDUSTRIAL APPLICABILITY
As shown obviously in above-mentioned description, the present invention
manufactured health supplementary food containing an Auricularia auricula rich in fibers
and natural gelatins, as an active ingredient. A continuous intake of the health
supplementary food according to the present invention increases the fecal excretion and
stimulates the bowel movements. Accordingly, it is effective in prevention and
treatment of constipation.
Claims
1. A Health supplementary food for improving constipation, which contains an
Auricularia auricula as an active ingredient.
2. The health supplementary food according to claim 1, wherein the food further
comprises a cascara sagrada
3. The health supplementary food according to claim 2, wherein the food further
comprises a magnesium hydroxide.
4. The health supplementary food according to claim 2, wherein the food further
comprises a powder of mulberry leaves.
5. The health supplementary food according to claim 2, wherein the food
comprises the following weight percentages of ingredients:
( i ) 60% to 90% Auricularia auricula; and
( i i ) 10% to 40% cascara sagrada.
6. The health supplementary food according to claim 3, wherein the food comprises the foUowing weight percentages of ingredients:
( i ) 60% to 85% Auricularia auricula;
( i i ) 10% to 35% cascara sagrada; and
(iii) 5% to 15% amagnesium hydroxide.
7. The health supplementary food according to claim 4, wherein the food
comprises the following weight percentages of ingredients:
( i ) 60% to 80% Auricularia auricula;
( i i ) 10% to 30% cascara sagrada; and
(iii ) 10% to 30% a powder of mulberry leaves.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR2001/0019803 | 2001-04-13 | ||
| KR20010019803 | 2001-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2002082928A1 true WO2002082928A1 (en) | 2002-10-24 |
Family
ID=19708206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2001/001611 WO2002082928A1 (en) | 2001-04-13 | 2001-09-26 | Health foods supplementary for treatment and prevention of constipation |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR100484428B1 (en) |
| WO (1) | WO2002082928A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104055878A (en) * | 2013-03-21 | 2014-09-24 | 申宏 | Dietotherapy composition capable of moistening intestines and relaxing bowel |
| CN104055851A (en) * | 2013-03-21 | 2014-09-24 | 李海波 | Dietotherapy composition capable of moistening intestines and relaxing bowel |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101132672B1 (en) | 2011-10-14 | 2012-04-03 | 주식회사 아이온커뮤니케이션즈 | Integrated authentication system using electronic contract |
| CN103830349A (en) * | 2014-03-22 | 2014-06-04 | 万世凤 | Method for making capsules for treating intractable constipation |
| CN104013723A (en) * | 2014-06-20 | 2014-09-03 | 孙苗苗 | Drug for treating gynecologic postoperative constipation |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0292251A (en) * | 1988-09-28 | 1990-04-03 | Nonogawa Shoji:Kk | Low-calorie beverage containing food fibers |
| US5039707A (en) * | 1989-09-08 | 1991-08-13 | Mobley James R | 1,3,6,8 tetrahydroxyanthraquinone |
| KR920003525B1 (en) * | 1987-09-28 | 1992-05-02 | 콜레트-마웰 호저 에이/에스 | Magnesium additive for nutrients feed and medicaments |
| JP2000281583A (en) * | 1999-03-26 | 2000-10-10 | Gotoo Corporation:Kk | Health auxiliary preparation containing leaf of mulberry and health auxiliary beverage and food |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2527754B2 (en) * | 1987-07-14 | 1996-08-28 | 三井製糖株式会社 | Food and drink |
| JPH0253459A (en) * | 1988-08-19 | 1990-02-22 | Maruzen Kasei Co Ltd | Water-soluble dietary fiber |
| EP0469555B1 (en) * | 1990-07-31 | 1996-04-17 | Nec Corporation | Charge storage capacitor electrode and method of manufacturing the same |
| JPH06153879A (en) * | 1992-11-20 | 1994-06-03 | Yutaka Kono | Production of drink from tremella fuciformis |
| JP2872635B2 (en) * | 1995-08-03 | 1999-03-17 | 千葉真知子クッキングスタジオ有限会社 | healthy food |
| KR20010073975A (en) * | 2000-10-02 | 2001-08-04 | 이창환 | a manufacturing method of the tea by using the cascara sagrada |
| KR20010103065A (en) * | 2001-07-23 | 2001-11-23 | 박재금 | Diet composition comprising dietary fiber |
-
2001
- 2001-09-26 WO PCT/KR2001/001611 patent/WO2002082928A1/en active Application Filing
-
2002
- 2002-04-12 KR KR10-2002-0020147A patent/KR100484428B1/en not_active IP Right Cessation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR920003525B1 (en) * | 1987-09-28 | 1992-05-02 | 콜레트-마웰 호저 에이/에스 | Magnesium additive for nutrients feed and medicaments |
| JPH0292251A (en) * | 1988-09-28 | 1990-04-03 | Nonogawa Shoji:Kk | Low-calorie beverage containing food fibers |
| US5039707A (en) * | 1989-09-08 | 1991-08-13 | Mobley James R | 1,3,6,8 tetrahydroxyanthraquinone |
| JP2000281583A (en) * | 1999-03-26 | 2000-10-10 | Gotoo Corporation:Kk | Health auxiliary preparation containing leaf of mulberry and health auxiliary beverage and food |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104055878A (en) * | 2013-03-21 | 2014-09-24 | 申宏 | Dietotherapy composition capable of moistening intestines and relaxing bowel |
| CN104055851A (en) * | 2013-03-21 | 2014-09-24 | 李海波 | Dietotherapy composition capable of moistening intestines and relaxing bowel |
Also Published As
| Publication number | Publication date |
|---|---|
| KR100484428B1 (en) | 2005-04-22 |
| KR20020079609A (en) | 2002-10-19 |
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