WO2002074922A3 - Compositions and methods for modulating an immune response - Google Patents

Compositions and methods for modulating an immune response Download PDF

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Publication number
WO2002074922A3
WO2002074922A3 PCT/US2002/008207 US0208207W WO02074922A3 WO 2002074922 A3 WO2002074922 A3 WO 2002074922A3 US 0208207 W US0208207 W US 0208207W WO 02074922 A3 WO02074922 A3 WO 02074922A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
immune response
modulating
compositions
immunomodulatory nucleic
Prior art date
Application number
PCT/US2002/008207
Other languages
French (fr)
Other versions
WO2002074922A2 (en
Inventor
David H Broide
Eyal Raz
Original Assignee
Univ California
David H Broide
Eyal Raz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, David H Broide, Eyal Raz filed Critical Univ California
Priority to AU2002248646A priority Critical patent/AU2002248646A1/en
Publication of WO2002074922A2 publication Critical patent/WO2002074922A2/en
Publication of WO2002074922A3 publication Critical patent/WO2002074922A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides methods of maintaining suppression of a Th2 immune response, and methods of maintaining an increase in a Th1 immune response in an individual. The methods generally involve administering to an individual an effective amount of a first dose of a composition comprising an immunomodulatory nucleic acid, and, after a suitable time, administering at least a second dose of a composition comprising an immunomodulatory nucleic acid. The various aspects of the mammalian immune system involved in responses to immunomodulatory nucleic acids are depicted in the accompanying figure.
PCT/US2002/008207 2001-03-16 2002-03-15 Compositions and methods for modulating an immune response WO2002074922A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002248646A AU2002248646A1 (en) 2001-03-16 2002-03-15 Compositions and methods for modulating an immune response

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27686501P 2001-03-16 2001-03-16
US60/276,865 2001-03-16

Publications (2)

Publication Number Publication Date
WO2002074922A2 WO2002074922A2 (en) 2002-09-26
WO2002074922A3 true WO2002074922A3 (en) 2003-02-20

Family

ID=23058390

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/008207 WO2002074922A2 (en) 2001-03-16 2002-03-15 Compositions and methods for modulating an immune response

Country Status (2)

Country Link
AU (1) AU2002248646A1 (en)
WO (1) WO2002074922A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9028845B2 (en) 2001-06-21 2015-05-12 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same-IV

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69932717T2 (en) 1998-05-22 2007-08-09 Ottawa Health Research Institute, Ottawa METHODS AND PRODUCTS FOR INDUCING MUCOSAL IMMUNITY
US8158768B2 (en) 2002-12-23 2012-04-17 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same
SG173219A1 (en) 2002-12-23 2011-08-29 Dynavax Tech Corp Immunostimulatory sequence oligonucleotides and methods of using the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAY ET AL.: "Allergic diseases and their treatment", N. ENGL. J. MED., vol. 344, no. 2, 11 January 2001 (2001-01-11), pages 109 - 113 *
SEREBRISKY ET AL.: "CpG oligonucleotides can reverse Th2-associated allergic airway responses and alter the B7.1/B7.2 expression in a murine model of asthma", J. OF IMMUNOL., vol. 165, no. 10, 2000, pages 5906 - 5912 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9028845B2 (en) 2001-06-21 2015-05-12 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same-IV

Also Published As

Publication number Publication date
WO2002074922A2 (en) 2002-09-26
AU2002248646A1 (en) 2002-10-03

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