WO2002068000A3 - Polymeric imagable brachytherapy seed - Google Patents

Polymeric imagable brachytherapy seed Download PDF

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Publication number
WO2002068000A3
WO2002068000A3 PCT/US2001/043517 US0143517W WO02068000A3 WO 2002068000 A3 WO2002068000 A3 WO 2002068000A3 US 0143517 W US0143517 W US 0143517W WO 02068000 A3 WO02068000 A3 WO 02068000A3
Authority
WO
WIPO (PCT)
Prior art keywords
brachytherapy
seeds
implantation
seed
diagnostic
Prior art date
Application number
PCT/US2001/043517
Other languages
French (fr)
Other versions
WO2002068000A2 (en
Inventor
Edward J Kaplan
Original Assignee
Microspherix Llc
Edward J Kaplan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/861,196 external-priority patent/US6514193B2/en
Application filed by Microspherix Llc, Edward J Kaplan filed Critical Microspherix Llc
Priority to AU2001297657A priority Critical patent/AU2001297657A1/en
Priority to EP01273840A priority patent/EP1372742A2/en
Publication of WO2002068000A2 publication Critical patent/WO2002068000A2/en
Publication of WO2002068000A3 publication Critical patent/WO2002068000A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1027—Interstitial radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1023—Means for creating a row of seeds, e.g. spacers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1024—Seeds

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A brachytherapy seed that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a polymeric carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Because the brachytherapy seeds can be sized and shaped to fit through the bore of a brachytherapy implantation needle, they are suitable for use with brachytherapy seed implantation instruments. A drug or other therapeutically active substance or diagnostic can be included in the seed in addition to, or as an alternative to, a radioisotope. The rate of release in the implantation site can be controlled by controlling the rate of degradation and/or release at the implantation site. In the preferred embodiment, the seeds also contain a radioopaque material or other means for external imaging. Like conventional radioactive brachytherapy seeds, the seeds can be precisely implanted in many different target tissues without the need for invasive surgery. Moreover, similar to the radiation emitted from conventional brachytherapy seeds, the therapeutically active substance included within a seed can be delivered in a controlled fashion over a relatively long period of time (e.g., weeks, months, or longer periods).
PCT/US2001/043517 2000-11-16 2001-11-16 Polymeric imagable brachytherapy seed WO2002068000A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001297657A AU2001297657A1 (en) 2000-11-16 2001-11-16 Polymeric imagable brachytherapy seed
EP01273840A EP1372742A2 (en) 2000-11-16 2001-11-16 Polymeric imagable brachytherapy seed

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US24912800P 2000-11-16 2000-11-16
US60/249,128 2000-11-16
US09/861,326 2001-05-18
US09/861,196 2001-05-18
US09/861,196 US6514193B2 (en) 2000-11-16 2001-05-18 Method of administering a therapeutically active substance
US09/861,326 US6746661B2 (en) 2000-11-16 2001-05-18 Brachytherapy seed

Publications (2)

Publication Number Publication Date
WO2002068000A2 WO2002068000A2 (en) 2002-09-06
WO2002068000A3 true WO2002068000A3 (en) 2003-10-23

Family

ID=27400179

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/043517 WO2002068000A2 (en) 2000-11-16 2001-11-16 Polymeric imagable brachytherapy seed

Country Status (3)

Country Link
EP (1) EP1372742A2 (en)
AU (1) AU2001297657A1 (en)
WO (1) WO2002068000A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003267309A1 (en) 2000-11-16 2004-04-08 Microspherix Llc Flexible and/or elastic brachytherapy seed or strand
US8827884B2 (en) 2009-08-06 2014-09-09 Koninklijke Philips N.V. Oncology therapies employing radioactive seeds
CA3059534A1 (en) 2017-05-11 2018-11-15 Alpha Tau Medical Ltd. Polymer coatings for brachytherapy devices
EP3773896A4 (en) * 2018-04-02 2022-01-12 Alpha TAU Medical Ltd. Controlled release of radionuclides
JP2024503995A (en) 2020-12-16 2024-01-30 アルファ タウ メディカル リミテッド Diffuse alpha emitter radiotherapy with enhanced beta radiation therapy

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003036A1 (en) * 1993-07-19 1995-02-02 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
WO1996014880A1 (en) * 1994-11-16 1996-05-23 Pgk, Enterprises, Inc. Method and apparatus for interstitial radiation of the prostate gland
US5886026A (en) * 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
WO2000032238A1 (en) * 1998-12-03 2000-06-08 Scimed Life Systems, Inc. Stent having drug crystals thereon
WO2000041185A1 (en) * 1999-01-07 2000-07-13 Nycomed Amersham Plc Improved brachytherapy seeds
WO2000043045A1 (en) * 1999-01-25 2000-07-27 Photogen, Inc. Method for improved radiation therapy
WO2000051639A2 (en) * 1999-03-01 2000-09-08 Halogenetics, Inc. Treatment of neoplastic diseases by radiation
WO2000057923A2 (en) * 1999-03-29 2000-10-05 North American Scientific, Inc. Radioactive seed with multiple markers and method for using same
WO2001036007A2 (en) * 1999-11-12 2001-05-25 Angiotech Pharmaceuticals, Inc. Compositions of a combination of radioactive therapy and cell-cycle inhibitors
WO2002030472A2 (en) * 2000-10-12 2002-04-18 Guilford Pharmaceuticals, Inc. Compositions for release of radiosensitizers, and methods of making and using the same

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003036A1 (en) * 1993-07-19 1995-02-02 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
US5886026A (en) * 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
US20030003094A1 (en) * 1993-07-19 2003-01-02 Hunter William L. Anti-angiogenic compositions and methods of use
WO1996014880A1 (en) * 1994-11-16 1996-05-23 Pgk, Enterprises, Inc. Method and apparatus for interstitial radiation of the prostate gland
WO2000032238A1 (en) * 1998-12-03 2000-06-08 Scimed Life Systems, Inc. Stent having drug crystals thereon
WO2000041185A1 (en) * 1999-01-07 2000-07-13 Nycomed Amersham Plc Improved brachytherapy seeds
WO2000043045A1 (en) * 1999-01-25 2000-07-27 Photogen, Inc. Method for improved radiation therapy
WO2000051639A2 (en) * 1999-03-01 2000-09-08 Halogenetics, Inc. Treatment of neoplastic diseases by radiation
WO2000057923A2 (en) * 1999-03-29 2000-10-05 North American Scientific, Inc. Radioactive seed with multiple markers and method for using same
WO2001036007A2 (en) * 1999-11-12 2001-05-25 Angiotech Pharmaceuticals, Inc. Compositions of a combination of radioactive therapy and cell-cycle inhibitors
US20020055666A1 (en) * 1999-11-12 2002-05-09 Hunter William L. Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors
WO2002030472A2 (en) * 2000-10-12 2002-04-18 Guilford Pharmaceuticals, Inc. Compositions for release of radiosensitizers, and methods of making and using the same

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
37TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR THERAPEUTIC RADIOLOGY AND ONCOLOGY, 8 October 1995 (1995-10-08), MIAMI BEACH, FLORIDA, USA *
DOIRON A ET AL: "TUMOR RADIOSENSITIZATION BY SUSTAINED INTRATUMORAL RELEASE OF BROMODEOXYURIDINE", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, no. 15, 1 August 1999 (1999-08-01), pages 3677 - 3681, XP001094937, ISSN: 0008-5472 *
HORIUCHI J ET AL: "RADIO THERAPY FOR CARCINOMA OF THE TONGUE WITH SPECIAL EMPHASIS ON THE ADVANCED CASES", JOURNAL OF JAPAN SOCIETY FOR CANCER THERAPY, vol. 15, no. 5, 1980, pages 851 - 857, XP008016950, ISSN: 0021-4671 *
PRESTIDGE BRADLEY R ET AL: "Post-treatment biopsy results following permanent transrectal ultrasound-guided interstitial brachytherapy in early stage prostate cancer.", INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol. 32, no. SUPPL. 1, 1995, pages 144, XP002249972, ISSN: 0360-3016 *
SEE WILLIAM A ET AL: "Brachytherapy and continuous infusion 5-fluorouracil for the treatment of locally advanced, lymph node negative, prostate cancer: A phase I trial.", CANCER, vol. 77, no. 5, 1996, pages 924 - 927, XP008016945, ISSN: 0008-543X *
YAPP D T T ET AL: "RADIOSENSITIZATION OF A MOUSE TUMOR MODEL BY SUSTAINED INTRA-TUMORAL RELEASEOF ETANIDAZOLE AND TIRAPAZAMINE USING A BIODEGRADABLE POLYMER IMPLANT DEVICE", RADIOTHERAPY AND ONCOLOGY, AMSTERDAM, NL, vol. 53, no. 1, October 1999 (1999-10-01), pages 77 - 84, XP001094931 *

Also Published As

Publication number Publication date
AU2001297657A1 (en) 2002-09-12
EP1372742A2 (en) 2004-01-02
WO2002068000A2 (en) 2002-09-06

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