WO2002062767A1 - Novel quinazoline derivatives - Google Patents
Novel quinazoline derivatives Download PDFInfo
- Publication number
- WO2002062767A1 WO2002062767A1 PCT/JP2002/001045 JP0201045W WO02062767A1 WO 2002062767 A1 WO2002062767 A1 WO 2002062767A1 JP 0201045 W JP0201045 W JP 0201045W WO 02062767 A1 WO02062767 A1 WO 02062767A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydrogen
- quinazoline derivatives
- general formula
- following general
- novel quinazoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Medicinal compositions for preventing or treating inflammatory diseases caused by bacterial DNA which contain as the active ingredient quinazoline derivatives represented by the following general formula (I), etc.: (I) wherein R?5, R6, R7 and R8¿ represent each hydrogen, etc.; R2 represents aryl, heteroaryl, etc.; n is 0 or 1; and X represents a group of the following general formula (a) or (b): (a) (b) wherein P represents C¿2-6? alkylene, etc.; R?9 and R10¿ represent hydrogen, etc.; Y represents CHR11 (wherein R11 represents hydrogen, etc.), etc.; and Z represents hydrogen, etc.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001-30973 | 2001-02-07 | ||
JP2001030973 | 2001-02-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002062767A1 true WO2002062767A1 (en) | 2002-08-15 |
Family
ID=18895118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/001045 WO2002062767A1 (en) | 2001-02-07 | 2002-02-07 | Novel quinazoline derivatives |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2002062767A1 (en) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006523238A (en) * | 2003-04-09 | 2006-10-12 | エクセリクシス, インク. | TIE-2 modulator and usage |
JP2007524615A (en) * | 2003-06-20 | 2007-08-30 | コーリー ファーマシューティカル ゲーエムベーハー | Low molecular weight Toll-like receptor (TLR) antagonist |
WO2007117161A1 (en) * | 2006-04-07 | 2007-10-18 | Auckland Uniservices Limited | Substituted ring fused azines and their use in cancer therapy |
JP2008526734A (en) * | 2004-12-31 | 2008-07-24 | エスケー ケミカルズ カンパニー リミテッド | Quinazoline derivatives effective in preventing diabetes and obesity |
US7632840B2 (en) | 2004-02-03 | 2009-12-15 | Astrazeneca Ab | Quinazoline compounds for the treatment of hyperproliferative disorders |
US7838530B2 (en) | 2003-09-25 | 2010-11-23 | Astrazeneca Ab | Quinazoline derivatives as antiproliferative agents |
US7910731B2 (en) | 2002-03-30 | 2011-03-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
US7998949B2 (en) | 2007-02-06 | 2011-08-16 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof |
US8088782B2 (en) | 2008-05-13 | 2012-01-03 | Astrazeneca Ab | Crystalline 4-(3-chloro-2-fluoroanilino)-7 methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline difumarate form A |
WO2012046207A1 (en) * | 2010-10-08 | 2012-04-12 | Paraco Technology Limited | Anti-parasitic substituted ring fused azine compounds |
WO2013003586A1 (en) | 2011-06-29 | 2013-01-03 | Otsuka Pharmaceutical Co., Ltd. | Quinazolines as therapeutic compounds and related methods of use |
US8399461B2 (en) | 2006-11-10 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for production of same |
US8497369B2 (en) | 2008-02-07 | 2013-07-30 | Boehringer Ingelheim International Gmbh | Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production |
US8507507B2 (en) | 2009-10-22 | 2013-08-13 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
US8575184B2 (en) | 2009-09-03 | 2013-11-05 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
US8648191B2 (en) | 2008-08-08 | 2014-02-11 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
JP2014141522A (en) * | 2008-03-13 | 2014-08-07 | Guangzhou Institute Of Biomedicine And Health Chinese Academy Of Sciences | Estrogen related receptor modulator compound and use thereof |
WO2015019121A1 (en) * | 2013-08-09 | 2015-02-12 | Vichem Chemie Kutató Kft. | Styryl quinazoline derivatives as pharmaceutically active agents |
US9073890B2 (en) | 2009-12-31 | 2015-07-07 | Otsuka Pharmaceutical Co., Ltd. | Therapeutic compounds and related methods of use |
CN111253325A (en) * | 2020-03-25 | 2020-06-09 | 广州大学 | Amino quinazoline aryl piperazine compound and pharmaceutical composition and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06192235A (en) * | 1992-07-15 | 1994-07-12 | Ono Pharmaceut Co Ltd | 4-aminoquinazoline derivative, its production and medicine containing the same derivative |
WO1999009986A1 (en) * | 1997-08-22 | 1999-03-04 | Kyowa Hakko Kogyo Co., Ltd. | 4-aminoquinazoline derivatives |
DE19756388A1 (en) * | 1997-12-18 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | New 2-aryl-4-amino-6,7-di:methoxy-quinazoline derivatives useful as guanylate cyclase activators for treating cardiovascular diseases, etc. |
-
2002
- 2002-02-07 WO PCT/JP2002/001045 patent/WO2002062767A1/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06192235A (en) * | 1992-07-15 | 1994-07-12 | Ono Pharmaceut Co Ltd | 4-aminoquinazoline derivative, its production and medicine containing the same derivative |
WO1999009986A1 (en) * | 1997-08-22 | 1999-03-04 | Kyowa Hakko Kogyo Co., Ltd. | 4-aminoquinazoline derivatives |
DE19756388A1 (en) * | 1997-12-18 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | New 2-aryl-4-amino-6,7-di:methoxy-quinazoline derivatives useful as guanylate cyclase activators for treating cardiovascular diseases, etc. |
Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8343982B2 (en) | 2002-03-30 | 2013-01-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocyclic compounds pharmaceutical compositions containing these compounds, their use and process for preparing the same |
US7910731B2 (en) | 2002-03-30 | 2011-03-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
JP2006523238A (en) * | 2003-04-09 | 2006-10-12 | エクセリクシス, インク. | TIE-2 modulator and usage |
JP4895806B2 (en) * | 2003-04-09 | 2012-03-14 | エクセリクシス, インク. | TIE-2 modulator and usage |
JP2007524615A (en) * | 2003-06-20 | 2007-08-30 | コーリー ファーマシューティカル ゲーエムベーハー | Low molecular weight Toll-like receptor (TLR) antagonist |
US7838530B2 (en) | 2003-09-25 | 2010-11-23 | Astrazeneca Ab | Quinazoline derivatives as antiproliferative agents |
US7632840B2 (en) | 2004-02-03 | 2009-12-15 | Astrazeneca Ab | Quinazoline compounds for the treatment of hyperproliferative disorders |
JP2008526734A (en) * | 2004-12-31 | 2008-07-24 | エスケー ケミカルズ カンパニー リミテッド | Quinazoline derivatives effective in preventing diabetes and obesity |
WO2007117161A1 (en) * | 2006-04-07 | 2007-10-18 | Auckland Uniservices Limited | Substituted ring fused azines and their use in cancer therapy |
JP2009533338A (en) * | 2006-04-07 | 2009-09-17 | オークランド ユニサーヴィスィズ リミテッド | Substituted ring fused azines and their use in cancer therapy |
US8399461B2 (en) | 2006-11-10 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for production of same |
US7998949B2 (en) | 2007-02-06 | 2011-08-16 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof |
US8772298B2 (en) | 2008-02-07 | 2014-07-08 | Boehringer Ingelheim International Gmbh | Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production |
US8497369B2 (en) | 2008-02-07 | 2013-07-30 | Boehringer Ingelheim International Gmbh | Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production |
JP2014141522A (en) * | 2008-03-13 | 2014-08-07 | Guangzhou Institute Of Biomedicine And Health Chinese Academy Of Sciences | Estrogen related receptor modulator compound and use thereof |
US8088782B2 (en) | 2008-05-13 | 2012-01-03 | Astrazeneca Ab | Crystalline 4-(3-chloro-2-fluoroanilino)-7 methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline difumarate form A |
US8648191B2 (en) | 2008-08-08 | 2014-02-11 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
US10676460B2 (en) | 2009-09-03 | 2020-06-09 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
US11008306B2 (en) | 2009-09-03 | 2021-05-18 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
US8575184B2 (en) | 2009-09-03 | 2013-11-05 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
US9458114B2 (en) | 2009-09-03 | 2016-10-04 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
US10214511B2 (en) | 2009-09-03 | 2019-02-26 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
US9822096B2 (en) | 2009-09-03 | 2017-11-21 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
US8507507B2 (en) | 2009-10-22 | 2013-08-13 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
US9161934B2 (en) | 2009-10-22 | 2015-10-20 | Gilead Sciences, Inc. | Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections |
US8962652B2 (en) | 2009-10-22 | 2015-02-24 | Gilead Sciences, Inc. | Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections |
EP3056207A1 (en) | 2009-12-31 | 2016-08-17 | Otsuka Pharmaceutical Co., Ltd. | Therapeutic compounds and related methods of use |
US9073890B2 (en) | 2009-12-31 | 2015-07-07 | Otsuka Pharmaceutical Co., Ltd. | Therapeutic compounds and related methods of use |
US9630947B2 (en) | 2009-12-31 | 2017-04-25 | Otsuka Pharmaceutical Co., Ltd. | Therapeutic compounds and related methods of use |
WO2012046207A1 (en) * | 2010-10-08 | 2012-04-12 | Paraco Technology Limited | Anti-parasitic substituted ring fused azine compounds |
WO2013003586A1 (en) | 2011-06-29 | 2013-01-03 | Otsuka Pharmaceutical Co., Ltd. | Quinazolines as therapeutic compounds and related methods of use |
US9951029B2 (en) | 2013-08-09 | 2018-04-24 | Vichem Chemie Kutató Kft. | Styryl quinazoline derivatives as pharmaceutically active agents |
WO2015019121A1 (en) * | 2013-08-09 | 2015-02-12 | Vichem Chemie Kutató Kft. | Styryl quinazoline derivatives as pharmaceutically active agents |
CN111253325A (en) * | 2020-03-25 | 2020-06-09 | 广州大学 | Amino quinazoline aryl piperazine compound and pharmaceutical composition and application thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2002062767A1 (en) | Novel quinazoline derivatives | |
ES2187473T3 (en) | TRIARYLIMIDAZOLES. | |
TR200200749T2 (en) | Quinazoline compounds and pharmaceutical compositions containing them. | |
WO2001014376A8 (en) | Novel spiro compounds | |
CA2183972A1 (en) | Oxazolidinone derivatives and pharmaceutical compositions containing them | |
PL368739A1 (en) | Acetylene derivatives having mglur 5 antagonistic activity | |
WO2002024686A3 (en) | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives | |
CA2414095A1 (en) | Novel compounds | |
NO992821L (en) | Ketobenzamides as Calpain Inhibitors | |
SE9904652D0 (en) | Novel Compounds | |
NO996108L (en) | 9 oksinerytromycinderivater | |
DE60118225D1 (en) | CHINOLIN AND CHINAZOLINE DERIVATIVES AND THEIR USE AS FARNESYL TRANSFERASE INHIBITORS | |
EP1396493A4 (en) | Heterocyclic compounds | |
NO20052182L (en) | New connections | |
CA2336412A1 (en) | Medicament for treatment of diabetes | |
EP1702917A4 (en) | Amide derivative and medicine | |
DE60039183D1 (en) | COMPOUNDS WITH ANTIBACTERIAL AND ANTIPARASITIC PROPERTIES | |
EP0765865A4 (en) | 2-acylaminopropanol compound and medicinal composition | |
WO2003051274A3 (en) | Benzodiazepine derivatives, preparation thereof and use thereof | |
WO2003053971A8 (en) | Pyridoquinoxaline antivirals | |
WO2002024697A1 (en) | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | |
SE0101038D0 (en) | Novel compounds | |
YU33202A (en) | Oxime o-ether compounds and fungicides for agricultural and horticultural use | |
EP1295880A4 (en) | Imidazole derivatives or salts thereof and drugs containing the derivatives or the salts | |
WO2001062709A3 (en) | Use of 2-phenylene diamine derivatives for the treatment of infections |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AU CA JP NZ US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: JP |