WO2002060947A3 - Glycoforms a fas ligand inhibitory protein analog - Google Patents

Glycoforms a fas ligand inhibitory protein analog Download PDF

Info

Publication number
WO2002060947A3
WO2002060947A3 PCT/US2002/000509 US0200509W WO02060947A3 WO 2002060947 A3 WO2002060947 A3 WO 2002060947A3 US 0200509 W US0200509 W US 0200509W WO 02060947 A3 WO02060947 A3 WO 02060947A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycoforms
fas ligand
inhibitory protein
protein analog
ligand inhibitory
Prior art date
Application number
PCT/US2002/000509
Other languages
French (fr)
Other versions
WO2002060947A8 (en
WO2002060947A2 (en
Inventor
Nigel Jenkins
Derrick Ryan Witcher
Victor John Wroblewski
Original Assignee
Lilly Co Eli
Nigel Jenkins
Derrick Ryan Witcher
Victor John Wroblewski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Nigel Jenkins, Derrick Ryan Witcher, Victor John Wroblewski filed Critical Lilly Co Eli
Priority to AU2002246967A priority Critical patent/AU2002246967A1/en
Publication of WO2002060947A2 publication Critical patent/WO2002060947A2/en
Publication of WO2002060947A3 publication Critical patent/WO2002060947A3/en
Publication of WO2002060947A8 publication Critical patent/WO2002060947A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides FLINT analog isoform compositions having specified average sialic acid content per molecule of FLINT analog.
PCT/US2002/000509 2001-02-01 2002-01-18 Glycoforms a fas ligand inhibitory protein analog WO2002060947A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002246967A AU2002246967A1 (en) 2001-02-01 2002-01-18 Glycoforms a fas ligand inhibitory protein analog

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26569001P 2001-02-01 2001-02-01
US60/265,690 2001-02-01

Publications (3)

Publication Number Publication Date
WO2002060947A2 WO2002060947A2 (en) 2002-08-08
WO2002060947A3 true WO2002060947A3 (en) 2002-10-31
WO2002060947A8 WO2002060947A8 (en) 2003-11-06

Family

ID=23011491

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/000509 WO2002060947A2 (en) 2001-02-01 2002-01-18 Glycoforms a fas ligand inhibitory protein analog

Country Status (2)

Country Link
AU (1) AU2002246967A1 (en)
WO (1) WO2002060947A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
CA2277925A1 (en) 1997-01-14 1998-07-16 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6.alpha. and 6.beta.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058466A2 (en) * 1999-03-30 2000-10-05 Eli Lilly And Company Protease resistant flint analogs
WO2000058465A2 (en) * 1999-03-30 2000-10-05 Eli Lilly And Company Flint polypeptide analogs
WO2001018055A1 (en) * 1999-09-10 2001-03-15 Eli Lilly And Company Flint analog compounds and formulations thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058466A2 (en) * 1999-03-30 2000-10-05 Eli Lilly And Company Protease resistant flint analogs
WO2000058465A2 (en) * 1999-03-30 2000-10-05 Eli Lilly And Company Flint polypeptide analogs
WO2001018055A1 (en) * 1999-09-10 2001-03-15 Eli Lilly And Company Flint analog compounds and formulations thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAI C ET AL: "OVEREXPRESSION OF M68/DCR3 IN HUMAN GASTROINTESTINAL TRACT TUMORS INDEPENDENT OF GENE AMPLIFICATION AND ITS LOCATION IN A FOUR-GENE CLUSTER", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 3, 1 February 2000 (2000-02-01), pages 1230 - 1235, XP002938755, ISSN: 0027-8424 *
KRONMAN C ET AL: "Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation.", THE BIOCHEMICAL JOURNAL. ENGLAND 1 NOV 1995, vol. 311 ( Pt 3), 1 November 1995 (1995-11-01), pages 959 - 967, XP008007650, ISSN: 0264-6021 *
PITTI ET AL: "Genomic amplification of a decoy receptor for FAS ligand in lung and colon cancer", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 396, 17 December 1998 (1998-12-17), pages 699 - 703, XP002139977, ISSN: 0028-0836 *
YU K-Y ET AL: "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 20, 14 May 1999 (1999-05-14), pages 13733 - 13736, XP002161940, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
AU2002246967A1 (en) 2002-08-12
WO2002060947A8 (en) 2003-11-06
WO2002060947A2 (en) 2002-08-08

Similar Documents

Publication Publication Date Title
WO2003012105A3 (en) Vegf isoform
WO2002100347A3 (en) Prodrugs of gaba analogs, compositions and uses thereof
WO2004074455A3 (en) Fc REGION VARIANTS
EP1308459A3 (en) Full-length cDNA sequences
AU2002363361A1 (en) Pharmaceutical compositions containing oxybutynin
AU2002308717A1 (en) Confectionery compositions
WO2003000186A3 (en) Novel phenylamino-pyrimidines and uses thereof
WO2006032697A3 (en) MODIFIED VPl-CAPSID PROTEIN OF PARVOVIRUS B19
WO2004087073A3 (en) Treatment of demyelinating conditions
AU2002365646A1 (en) Novel proteins with il-6 inhibiting activity
WO2003010291A3 (en) Treatment of immune disorders and b cell disorders
EP1262556A3 (en) Antimicrobial peptides and method for identifying and using such peptides
WO2002062304A3 (en) Cosmetic and/or pharmaceutical agents containing an acylated amino acid and a protein condensate
AU2002347377A1 (en) Sustained-release compositions
WO2004039834A3 (en) Recombinant protein variants
WO2004110469A3 (en) Formulations comprising factor viia and a factor vii related polypeptide
WO2002060947A8 (en) Glycoforms a fas ligand inhibitory protein analog
AU2002225387A1 (en) Polypeptide having alpha-isomaltosylglucosaccharide synthase activity
WO2002055547A3 (en) Sfrp and peptide motifs that interact with sfrp and methods of their use
WO2004019965A3 (en) Thymus-based tolerogenic approaches for type i diabetes.
WO2002060949A3 (en) Glycoforms a fas ligand inhibitory protein analog
WO2003057712A3 (en) Humanized lactoferrin and uses thereof
WO2002089740A3 (en) Sulfonamides
WO2004089302A3 (en) Posh polypeptides, complexes and related methods
WO2004089281A3 (en) Novel polymorphs of tolterodine tartrate

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ CZ DE DE DK DK DM DZ EC EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 32/2002 DUE TO A TECHNICAL PROBLEM AT THE TIME OF INTERNATIONAL PUBLICATION, SOME INFORMATION WAS MISSING (81). THE MISSING INFORMATION NOW APPEARS IN THE CORRECTED VERSION.

Free format text: IN PCT GAZETTE 32/2002 DUE TO A TECHNICAL PROBLEM AT THE TIME OF INTERNATIONAL PUBLICATION, SOME INFORMATION WAS MISSING (81). THE MISSING INFORMATION NOW APPEARS IN THE CORRECTED VERSION.

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP