WO2002054868A3 - Pulmonary delivery of polyene antifungal agents - Google Patents
Pulmonary delivery of polyene antifungal agents Download PDFInfo
- Publication number
- WO2002054868A3 WO2002054868A3 PCT/US2001/050241 US0150241W WO02054868A3 WO 2002054868 A3 WO2002054868 A3 WO 2002054868A3 US 0150241 W US0150241 W US 0150241W WO 02054868 A3 WO02054868 A3 WO 02054868A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polyene
- antifungal agents
- pulmonary delivery
- polyene antifungal
- spray
- Prior art date
Links
- 150000004291 polyenes Chemical class 0.000 title abstract 4
- 230000002685 pulmonary effect Effects 0.000 title abstract 2
- 229940121375 antifungal agent Drugs 0.000 title 1
- 239000003429 antifungal agent Substances 0.000 title 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 239000012871 anti-fungal composition Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020037008493A KR100743404B1 (en) | 2000-12-21 | 2001-12-21 | Pulmonary delivery of polyene antifungal agents |
CA002432319A CA2432319A1 (en) | 2000-12-21 | 2001-12-21 | Pulmonary delivery of polyene antifungal agents |
AU2002245181A AU2002245181B2 (en) | 2000-12-21 | 2001-12-21 | Pulmonary delivery of polyene antifungal agents |
EP01993340A EP1343372A2 (en) | 2000-12-21 | 2001-12-21 | Pulmonary delivery of polyene antifungal agents |
JP2002555618A JP2004517127A (en) | 2000-12-21 | 2001-12-21 | Pulmonary delivery of polyene antifungals |
MXPA03005655A MXPA03005655A (en) | 2000-12-21 | 2001-12-21 | Pulmonary delivery of polyene antifungal agents. |
AU2006222737A AU2006222737A1 (en) | 2000-12-21 | 2006-09-28 | Pulmonary delivery of polyene antifungal agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25761300P | 2000-12-21 | 2000-12-21 | |
US60/257,613 | 2000-12-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002054868A2 WO2002054868A2 (en) | 2002-07-18 |
WO2002054868A3 true WO2002054868A3 (en) | 2003-03-27 |
Family
ID=22977001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/050241 WO2002054868A2 (en) | 2000-12-21 | 2001-12-21 | Pulmonary delivery of polyene antifungal agents |
Country Status (8)
Country | Link |
---|---|
US (2) | US7473433B2 (en) |
EP (1) | EP1343372A2 (en) |
JP (1) | JP2004517127A (en) |
KR (1) | KR100743404B1 (en) |
AU (2) | AU2002245181B2 (en) |
CA (1) | CA2432319A1 (en) |
MX (1) | MXPA03005655A (en) |
WO (1) | WO2002054868A2 (en) |
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US6045815A (en) * | 1997-08-15 | 2000-04-04 | Board Of Regents, The University Of Texas System | Parenteral pimaricin as treatment of systemic infections |
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US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
US8404217B2 (en) * | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
AU2002335046A1 (en) * | 2001-10-19 | 2003-05-06 | Inhale Therapeutic Systems, Inc. | The use of proton sequestering agents in drug formulations |
WO2003041500A1 (en) * | 2001-11-14 | 2003-05-22 | Board Of Regents, The University Of Texas System | Topical formulations of natamycin/pimaricin |
US20050220720A1 (en) * | 2002-05-02 | 2005-10-06 | David Edwards | Formulations limiting spread of pulmonary infections |
CA2483917C (en) | 2002-05-02 | 2013-07-30 | President And Fellows Of Harvard College | Formulations limiting spread of pulmonary infections |
MXPA05007156A (en) * | 2002-12-31 | 2005-09-21 | Nektar Therapeutics | Aerosolizable pharmaceutical formulation for fungal infection therapy. |
KR20050095838A (en) | 2002-12-31 | 2005-10-04 | 넥타르 테라퓨틱스 | Pharmaceutical formulation with an insoluble active agent for pulmonary administration |
EP1635762B1 (en) * | 2003-06-13 | 2021-03-03 | Civitas Therapeutics, Inc. | Low dose pharmaceutical powders for inhalation |
US20050207983A1 (en) | 2004-03-05 | 2005-09-22 | Pulmatrix, Inc. | Formulations decreasing particle exhalation |
AU2005258040A1 (en) | 2004-06-21 | 2006-01-05 | Novartis Ag | Compositions comprising amphotericin b |
US8513204B2 (en) | 2004-06-21 | 2013-08-20 | Novartis Ag | Compositions comprising amphotericin B, mehods and systems |
WO2006026502A1 (en) * | 2004-08-27 | 2006-03-09 | The Dow Chemical Company | Enhanced delivery of drug compositions to treat life threatening infections |
US20060260606A1 (en) * | 2005-05-18 | 2006-11-23 | Coifman Robert E | Inhalable formulations of amphotericin B and methods and devices for delivery thereof |
WO2006125153A2 (en) * | 2005-05-18 | 2006-11-23 | Pulmatrix Inc. | Formulations for alteration of biophysical properties of mucosal lining |
EP1928525A2 (en) * | 2005-09-29 | 2008-06-11 | Nektar Therapeutics | Receptacles and kits, such as for dry powder packaging |
US20120128728A1 (en) * | 2005-12-28 | 2012-05-24 | Novartis Pharma Ag | Compositions Comprising Amphotericin B |
EP2079306A4 (en) * | 2006-10-03 | 2009-12-30 | Accentia Biopharmaceuticals In | Mucosally non-irritative amphotericin b formulations and methods for treating non-invasive fungus-induced mucositis |
GB2448183A (en) * | 2007-04-05 | 2008-10-08 | Optinose As | Nasal powder delivery device |
EP2050437A1 (en) * | 2007-10-15 | 2009-04-22 | Laboratoires SMB | Improved pharmaceutical dry powder compositions for inhalation. |
RU2497524C2 (en) | 2008-05-15 | 2013-11-10 | Новартис Аг | Intrapulmonary administration of fuoroquinolone |
EP2413902B1 (en) | 2009-03-18 | 2019-07-17 | Incarda Therapeutics, Inc. | Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration |
US20130164338A1 (en) | 2010-08-30 | 2013-06-27 | Pulmatrix, Inc. | Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder |
CN103200938B (en) | 2010-08-30 | 2018-07-31 | 普马特里克斯营业公司 | Dried powder formula and method for treating pulmonary disease |
DK2621488T3 (en) | 2010-09-29 | 2019-03-04 | Pulmatrix Operating Co Inc | CATIONIC DRY POWDER |
RU2640921C2 (en) | 2010-09-29 | 2018-01-12 | Пулмэтрикс, Инк. | Cations of monovalent metals of dry powders for inhalations |
WO2013130767A1 (en) | 2012-02-29 | 2013-09-06 | Pulmatrix, Inc. | Inhalable dry powders |
TWI528468B (en) | 2012-05-30 | 2016-04-01 | 國立中山大學 | A mimo antenna, antenna unit thereof and a system in package having said antenna |
US8920364B2 (en) | 2013-02-28 | 2014-12-30 | Medtronic Xomed, Inc. | Biomaterial delivery device |
US8845578B2 (en) * | 2013-02-28 | 2014-09-30 | Medtronic Xomed, Inc. | Biomaterial delivery device |
CN105324106A (en) | 2013-04-01 | 2016-02-10 | 普马特里克斯营业公司 | Tiotropium dry powders |
IL260335B2 (en) | 2016-02-01 | 2023-10-01 | Incarda Therapeutics Inc | Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation |
MX2019004322A (en) * | 2016-10-14 | 2019-12-11 | Pulmatrix Operating Co Inc | Antifungal dry powders. |
AU2018266199A1 (en) | 2017-05-10 | 2019-11-07 | Incarda Therapeutics, Inc. | Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration |
EP3768378A4 (en) | 2018-03-22 | 2021-11-17 | InCarda Therapeutics, Inc. | A novel method to slow ventricular rate |
US20210145739A1 (en) * | 2018-04-18 | 2021-05-20 | Pulmatrix Operating Company, Inc. | Antifungal formulations for pulmonary administration comprising itraconazole |
US10569244B2 (en) | 2018-04-28 | 2020-02-25 | ZoomEssence, Inc. | Low temperature spray drying of carrier-free compositions |
US11020384B2 (en) | 2019-08-01 | 2021-06-01 | Incarda Therapeutics, Inc. | Antiarrhythmic formulation |
WO2023086013A2 (en) * | 2021-11-09 | 2023-05-19 | Agency For Science, Technology And Research | A salt-based antifungal powder platform formulation for aerosolization |
WO2023229023A1 (en) * | 2022-05-25 | 2023-11-30 | 学校法人 名城大学 | Powdered agent and production method for same |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1996032149A1 (en) * | 1995-04-14 | 1996-10-17 | Inhale Therapeutic Systems | Pulmonary delivery of aerosolized medicaments |
WO1997003649A1 (en) * | 1995-07-24 | 1997-02-06 | Co-Ordinated Drug Development Ltd. | Improvements in and relating to powders for use in dry powder inhalers |
US6001336A (en) * | 1996-12-31 | 1999-12-14 | Inhale Therapeutic Systems | Processes for spray drying aqueous suspensions of hydrophobic drugs and compositions thereof |
WO2000061178A1 (en) * | 1999-04-13 | 2000-10-19 | Inhale Therapeutics Systems, Inc. | Pulmonary administration of dry powder formulations for treating infertility |
WO2001032144A1 (en) * | 1999-10-29 | 2001-05-10 | Inhale Therapeutic Systems, Inc. | Dry powder compositions having improved dispersivity |
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US4027015A (en) | 1974-03-11 | 1977-05-31 | Schering Corporation | Antibiotic 67-121, a polyene antifungal antibiotic produced by actinoplanes caeruleus |
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MXPA05007156A (en) * | 2002-12-31 | 2005-09-21 | Nektar Therapeutics | Aerosolizable pharmaceutical formulation for fungal infection therapy. |
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EP1928525A2 (en) * | 2005-09-29 | 2008-06-11 | Nektar Therapeutics | Receptacles and kits, such as for dry powder packaging |
-
2001
- 2001-12-21 JP JP2002555618A patent/JP2004517127A/en active Pending
- 2001-12-21 WO PCT/US2001/050241 patent/WO2002054868A2/en not_active Application Discontinuation
- 2001-12-21 CA CA002432319A patent/CA2432319A1/en not_active Abandoned
- 2001-12-21 US US10/032,239 patent/US7473433B2/en not_active Expired - Fee Related
- 2001-12-21 MX MXPA03005655A patent/MXPA03005655A/en active IP Right Grant
- 2001-12-21 AU AU2002245181A patent/AU2002245181B2/en not_active Ceased
- 2001-12-21 EP EP01993340A patent/EP1343372A2/en not_active Withdrawn
- 2001-12-21 KR KR1020037008493A patent/KR100743404B1/en not_active IP Right Cessation
-
2006
- 2006-09-28 AU AU2006222737A patent/AU2006222737A1/en not_active Abandoned
-
2008
- 2008-11-24 US US12/277,266 patent/US20090081302A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996032149A1 (en) * | 1995-04-14 | 1996-10-17 | Inhale Therapeutic Systems | Pulmonary delivery of aerosolized medicaments |
WO1997003649A1 (en) * | 1995-07-24 | 1997-02-06 | Co-Ordinated Drug Development Ltd. | Improvements in and relating to powders for use in dry powder inhalers |
US6001336A (en) * | 1996-12-31 | 1999-12-14 | Inhale Therapeutic Systems | Processes for spray drying aqueous suspensions of hydrophobic drugs and compositions thereof |
WO2000061178A1 (en) * | 1999-04-13 | 2000-10-19 | Inhale Therapeutics Systems, Inc. | Pulmonary administration of dry powder formulations for treating infertility |
WO2001032144A1 (en) * | 1999-10-29 | 2001-05-10 | Inhale Therapeutic Systems, Inc. | Dry powder compositions having improved dispersivity |
Also Published As
Publication number | Publication date |
---|---|
KR100743404B1 (en) | 2007-07-30 |
US7473433B2 (en) | 2009-01-06 |
CA2432319A1 (en) | 2002-07-18 |
MXPA03005655A (en) | 2004-12-03 |
KR20030067718A (en) | 2003-08-14 |
US20020177562A1 (en) | 2002-11-28 |
AU2002245181B2 (en) | 2006-06-29 |
JP2004517127A (en) | 2004-06-10 |
AU2006222737A1 (en) | 2006-10-19 |
EP1343372A2 (en) | 2003-09-17 |
WO2002054868A2 (en) | 2002-07-18 |
US20090081302A1 (en) | 2009-03-26 |
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