WO2002007660A3 - Methods and instruments for refractive ophthalmic surgery - Google Patents

Methods and instruments for refractive ophthalmic surgery Download PDF

Info

Publication number
WO2002007660A3
WO2002007660A3 PCT/US2001/022936 US0122936W WO0207660A3 WO 2002007660 A3 WO2002007660 A3 WO 2002007660A3 US 0122936 W US0122936 W US 0122936W WO 0207660 A3 WO0207660 A3 WO 0207660A3
Authority
WO
WIPO (PCT)
Prior art keywords
flap
cornea
operative
model
corneal
Prior art date
Application number
PCT/US2001/022936
Other languages
French (fr)
Other versions
WO2002007660A2 (en
Inventor
Cynthia Roberts
William J Dupps Jr
Noriko Katsube
Original Assignee
Univ Ohio State
Cynthia Roberts
William J Dupps Jr
Noriko Katsube
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ohio State, Cynthia Roberts, William J Dupps Jr, Noriko Katsube filed Critical Univ Ohio State
Priority to AU2001277038A priority Critical patent/AU2001277038A1/en
Priority to US10/332,891 priority patent/US20030208190A1/en
Priority to JP2002513398A priority patent/JP2004504105A/en
Priority to CA002416598A priority patent/CA2416598A1/en
Priority to EP01954818A priority patent/EP1301155A2/en
Publication of WO2002007660A2 publication Critical patent/WO2002007660A2/en
Publication of WO2002007660A3 publication Critical patent/WO2002007660A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F9/00802—Methods or devices for eye surgery using laser for photoablation
    • A61F9/00804—Refractive treatments
    • A61F9/00806—Correction of higher orders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00855—Calibration of the laser system
    • A61F2009/00857—Calibration of the laser system considering biodynamics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00872—Cornea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00878—Planning
    • A61F2009/0088—Planning based on wavefront
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00878—Planning
    • A61F2009/00882—Planning based on topography

Abstract

Biomechanical responses of the eye are used to improve photorefractive procedures. LASIK or PRK treatments, for example, can be improved by taking pre-operative measurement and predicting the corneas's biodynamic response to the ablative treatment. Predicitve use is mad of the biodynamic response of the cornea due to laser or mechanical keratectomy, that is, creating a corneal flap characterisitc of LASIK. Comparison of pre-flap and post-flap, (pre-ablation) data of the cornea such as corneal thickness, flap thickness, corneal topography and wavefront, for example, can provide predictive information applicable to modifying an ablation alorithm before the laser is engaged, either for a current operation or the development of a model. Modeling, by finite element analysis or other mathematical techniques, can also be used to predict post-operative outcomes based on a pre-operative (no flap cut or other surgical intervention) data for the cornea that is input for an accurate eye model that, in consideration of biodynamic response ∫i⊃via∫/i⊃ the model, provides predictive information for optimizing the sucess of the refractive surgery and ultimately patient satisfaction.
PCT/US2001/022936 2000-07-20 2001-07-20 Methods and instruments for refractive ophthalmic surgery WO2002007660A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001277038A AU2001277038A1 (en) 2000-07-21 2001-07-20 Methods and instruments for improving refractive ophthalmic surgery
US10/332,891 US20030208190A1 (en) 2001-07-20 2001-07-20 Methods and instruments for refractive ophthalmic surgery
JP2002513398A JP2004504105A (en) 2000-07-21 2001-07-20 Method and apparatus for refractive eye surgery
CA002416598A CA2416598A1 (en) 2000-07-21 2001-07-20 Methods and instruments for refractive ophthalmic surgery
EP01954818A EP1301155A2 (en) 2000-07-20 2001-07-20 Methods and instruments for refractive ophthalmic surgery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22001900P 2000-07-21 2000-07-21
US60/220,019 2000-07-21

Publications (2)

Publication Number Publication Date
WO2002007660A2 WO2002007660A2 (en) 2002-01-31
WO2002007660A3 true WO2002007660A3 (en) 2002-05-30

Family

ID=22821710

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/022936 WO2002007660A2 (en) 2000-07-20 2001-07-20 Methods and instruments for refractive ophthalmic surgery

Country Status (6)

Country Link
EP (1) EP1301155A2 (en)
JP (1) JP2004504105A (en)
AU (1) AU2001277038A1 (en)
CA (1) CA2416598A1 (en)
SG (1) SG127691A1 (en)
WO (1) WO2002007660A2 (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2277430T3 (en) 1998-03-04 2007-07-01 Visx Incorporated LASER PRESBORAGE TREATMENT SYSTEM.
US7130835B2 (en) * 2002-03-28 2006-10-31 Bausch & Lomb Incorporated System and method for predictive ophthalmic correction
WO2003101355A1 (en) 2002-05-31 2003-12-11 Carl Zeiss Meditec Ag Method for controlling a device for treating the human eye
AU2003284208A1 (en) 2002-10-15 2004-05-04 The Ohio State University Customized transition zone system and method for an ablation pattern
US6939342B2 (en) * 2002-12-12 2005-09-06 Bausch And Lomb Incorporated System and method for evaluating a secondary LASIK treatment
EP1575466B1 (en) * 2002-12-16 2012-04-18 The Ohio State University Parametric model based ablative surgical systems and methods
US7004902B2 (en) * 2003-03-21 2006-02-28 Reichert, Inc. Method and apparatus for measuring biomechanical characteristics of corneal tissue
US7703919B2 (en) * 2003-03-28 2010-04-27 Digital Vision, Llc Application of neuro-ocular wavefront data in vision correction
EP1462074A1 (en) * 2003-03-28 2004-09-29 Cesar C. Dr. Carriazo Ablation depth control system for corneal surgery
WO2004095187A2 (en) 2003-04-18 2004-11-04 Visx, Incorporated Systems and methods for correcting high order aberrations in laser refractive surgery
ES2253951B1 (en) * 2003-09-08 2007-08-01 INSTITUTO NACIONAL DE TECNICA AEROESPACIAL "ESTEBAN TERRADAS". SYSTEM FOR THE DESIGN OF PERSONALIZED CORNEAL PHOTO-ABLATION PATTERNS, OBTAINED PATTERN AND LASER SURGERY SYSTEM FOR CORNEA CARVING.
JP4897497B2 (en) 2004-02-20 2012-03-14 ヴィズイクス・インコーポレーテッド Volume point spread function for eye diagnosis and treatment
EP1740346A4 (en) * 2004-02-20 2009-08-12 Ophthonix Inc System and method for analyzing wavefront aberrations
ES2253078B1 (en) * 2004-06-11 2007-07-16 Consejo Superior De Investigaciones Cientificas. PROCEDURE TO AVOID THE INDUCTION OF ABERRATIONS IN LASER REFRACTIVE SURGERY SYSTEMS.
DE102004033819B8 (en) * 2004-07-13 2011-11-10 Wavelight Gmbh Method for generating control data of a laser system for ophthalmological procedures
US10729585B2 (en) 2006-07-19 2020-08-04 Alcon Inc. Computer program for ophthalmological surgery
KR101683042B1 (en) 2008-04-04 2016-12-06 포사이트 비젼4, 인크. Therapeutic device for pain management and vision
ES2571790T3 (en) * 2008-06-30 2016-05-26 Wavelight Gmbh Device, procedure and control program for ophthalmic laser surgery, in particular refractive laser surgery
AU2008361191B2 (en) * 2008-08-29 2013-07-25 Alcon Inc. Method for calibrating the pulse energy of a laser device using a coherence-optical interferometric measuring apparatus
DE102008046834A1 (en) 2008-09-11 2010-03-18 Iroc Ag Control program for controlling electromagnetic radiation for cross-linking of eye tissue
WO2011050327A1 (en) 2009-10-23 2011-04-28 Forsight Labs Llc Corneal denervation for treatment of ocular pain
WO2011050365A1 (en) 2009-10-23 2011-04-28 Forsight Labs, Llc Conformable therapeutic shield for vision and pain
US8591025B1 (en) 2012-09-11 2013-11-26 Nexisvision, Inc. Eye covering and refractive correction methods for LASIK and other applications
US8409178B2 (en) 2010-03-30 2013-04-02 Amo Development Llc. Systems and methods for evaluating treatment tables for refractive surgery
US9642518B2 (en) 2010-03-30 2017-05-09 Amo Development, Llc Random eye generation systems and methods
CA2816031A1 (en) 2010-10-25 2012-05-10 Nexisvision, Inc. Methods and apparatus to identify eye coverings for vision
US10583039B2 (en) 2010-12-30 2020-03-10 Amo Wavefront Sciences, Llc Method and system for eye measurements and cataract surgery planning using vector function derived from prior surgeries
US10582847B2 (en) 2010-12-30 2020-03-10 Amo Wavefront Sciences, Llc Method and system for eye measurements and cataract surgery planning using vector function derived from prior surgeries
US10582846B2 (en) 2010-12-30 2020-03-10 Amo Wavefront Sciences, Llc Method and system for eye measurements and cataract surgery planning using vector function derived from prior surgeries
US10500092B2 (en) 2010-12-30 2019-12-10 Amo Wavefront Sciences, Llc Treatment planning method and system for controlling laser refractive surgery
US9501621B2 (en) 2011-03-18 2016-11-22 Amo Development, Llc Treatment validation systems and methods
KR20140023378A (en) 2011-04-28 2014-02-26 넥시스비젼, 인코포레이티드 Eye covering and refractive correction methods and apparatus having improved tear flow, comfort, and/or applicability
AU2011373964B2 (en) * 2011-07-28 2015-01-15 Alcon Inc. Device for assisting in the preparation of an operation on the human eye
DE102011083789A1 (en) * 2011-09-29 2013-04-04 Oculus Optikgeräte GmbH Ophthalmological analysis method
JP2013153881A (en) * 2012-01-27 2013-08-15 Canon Inc Image processing system, processing method, and program
US9465233B2 (en) 2012-04-20 2016-10-11 Nexisvision, Inc. Bimodular contact lenses
CN104335104B (en) 2012-04-20 2017-06-09 内希斯视觉股份有限公司 For the contact lens of correction of refractive errors
JP6310072B2 (en) 2013-06-26 2018-04-11 ネクシスビジョン， インコーポレイテッド Contact lenses for refractive correction
EP2824599A1 (en) 2013-07-10 2015-01-14 ISS Integrated Scientific Device and method for the modelling of a cornea
US9341864B2 (en) 2013-11-15 2016-05-17 Nexisvision, Inc. Contact lenses having a reinforcing scaffold
WO2015116559A1 (en) 2014-01-29 2015-08-06 Nexisvision, Inc. Multifocal bimodulus contact lenses
KR101581834B1 (en) * 2015-03-24 2015-12-31 박기성 Integrated corneal photoablation system for correction of both shape error and curvature error
US11330980B2 (en) * 2015-12-08 2022-05-17 Narayana Nethralaya Foundation Index for quanitification of bowman's layer roughness for diagnosis of disease and prognosis of treatments in human cornea
US10426551B2 (en) 2016-12-09 2019-10-01 Microsoft Technology Licensing, Llc Personalized refractive surgery recommendations for eye patients
US11638661B2 (en) 2018-11-20 2023-05-02 Mark Lobanoff Intelligent topographic corneal procedure advisor
US11701258B2 (en) 2018-11-20 2023-07-18 Mark Lobanoff Intelligent corneal procedure advisor
KR20210156839A (en) * 2019-05-03 2021-12-27 렌사르, 인크. Cloud-based system cataract treatment database and algorithm system
WO2021173843A1 (en) * 2020-02-25 2021-09-02 Mark Lobanoff Epithelial thickness mapping and corneal procedure advisor
CN114522020B (en) * 2022-02-21 2022-12-02 华中科技大学 Personalized refractive surgery device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721379A (en) * 1985-01-16 1988-01-26 Lri L.P. Apparatus for analysis and correction of abnormal refractive errors of the eye
US4941093A (en) * 1985-09-12 1990-07-10 Summit Technology, Inc. Surface erosion using lasers
US5098426A (en) * 1989-02-06 1992-03-24 Phoenix Laser Systems, Inc. Method and apparatus for precision laser surgery
WO1993016631A1 (en) * 1992-02-27 1993-09-02 Phoenix Laser Systems, Inc. Automated laser workstation for high precision surgical and industrial interventions
US5891131A (en) * 1993-02-01 1999-04-06 Arizona Board Of Regents Method and apparatus for automated simulation and design of corneal refractive procedures

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11128264A (en) * 1997-10-24 1999-05-18 Nidek Co Ltd Ablation rate meter and ablation device with the same
WO2001028477A1 (en) * 1999-10-21 2001-04-26 Technolas Gmbh Ophthalmologische Systeme Multi-step laser correction of ophthalmic refractive errors
US6419671B1 (en) * 1999-12-23 2002-07-16 Visx, Incorporated Optical feedback system for vision correction
AU2001260197A1 (en) * 2000-04-11 2001-10-23 Thomas Bende Selective corneal aberrometry
US6582078B2 (en) * 2001-02-27 2003-06-24 Barton L. Halpern Method and system for planning corrective refractive surgery

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721379A (en) * 1985-01-16 1988-01-26 Lri L.P. Apparatus for analysis and correction of abnormal refractive errors of the eye
US4941093A (en) * 1985-09-12 1990-07-10 Summit Technology, Inc. Surface erosion using lasers
US5098426A (en) * 1989-02-06 1992-03-24 Phoenix Laser Systems, Inc. Method and apparatus for precision laser surgery
WO1993016631A1 (en) * 1992-02-27 1993-09-02 Phoenix Laser Systems, Inc. Automated laser workstation for high precision surgical and industrial interventions
US5891131A (en) * 1993-02-01 1999-04-06 Arizona Board Of Regents Method and apparatus for automated simulation and design of corneal refractive procedures

Also Published As

Publication number Publication date
EP1301155A2 (en) 2003-04-16
SG127691A1 (en) 2006-12-29
AU2001277038A1 (en) 2002-02-05
CA2416598A1 (en) 2002-01-31
JP2004504105A (en) 2004-02-12
WO2002007660A2 (en) 2002-01-31

Similar Documents

Publication Publication Date Title
WO2002007660A3 (en) Methods and instruments for refractive ophthalmic surgery
Binder One thousand consecutive IntraLase laser in situ keratomileusis flaps
AU2003303332B9 (en) Parametric model based ablative surgical systems and methods
Solomon et al. Flap thickness accuracy: comparison of 6 microkeratome models
Walker et al. Lower intraoperative flap complication rate with the Hansatome microkeratome compared to the Automated Corneal Shaper
Chen et al. Comparison of biomechanical effects of small incision lenticule extraction and laser‐assisted subepithelial keratomileusis
JP2009502289A (en) System and method for compensating corneal incision
Patel et al. Changes in the refractive index of the human corneal stroma during laser in situ keratomileusis: Effects of exposure time and method used to create the flap
EP1666009A3 (en) system for refractive ophthalmic surgery
US20070142826A1 (en) Modification of laser ablation treatment prescription using corneal mechanical properties and associated methods
Roberts Future challenges to aberration-free ablative procedures
Van Gelder et al. Comparison of photorefractive keratectomy, astigmatic PRK, laser in situ keratomileusis, and astigmatic LASIK in the treatment of myopia
Ganesh et al. Lenticuloschisis: a “no dissection” technique for lenticule extraction in small incision lenticule extraction
Muallem et al. Corneal flap thickness in laser in situ keratomileusis using the Moria M2 microkeratome
Goggin et al. Management of irregular astigmatism
Hu et al. Predictive formula for calculating the probability of LASIK enhancement
Arbelaez Nidek MK 2000 microkeratome clinical evaluation
Blaker et al. Theoretical and clinical effect of preoperative corneal curvature on excimer laser photorefractive keratectomy for myopia
de Ortueta et al. Influence of stromal refractive index and hydration on corneal laser refractive surgery
Montanino et al. Modeling the biomechanics of laser corneal refractive surgery
Gatinel et al. Comparison of the effect of LASIK parameters on the percent tissue altered (1-dimensional metric) versus percent volume altered (3-dimensional metric)
Langenbucher et al. Consideration of the posterior corneal curvature for assessment of corneal power after myopic LASIK
Huhtala et al. Corneal flap thickness with the Moria M2 single‐use head 90 microkeratome
Fleming et al. Intrastromal corneal ring segments in a patient with previous laser in situ keratomileusis
Nagy et al. Ultrasound evaluation of flap thickness, ablation depth, and corneal edema after laser in situ keratomileusis

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10332891

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2416598

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001954818

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001954818

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2001954818

Country of ref document: EP