WO2001079232A3 - Haplotypes of the mpl gene - Google Patents

Haplotypes of the mpl gene Download PDF

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Publication number
WO2001079232A3
WO2001079232A3 PCT/US2001/012301 US0112301W WO0179232A3 WO 2001079232 A3 WO2001079232 A3 WO 2001079232A3 US 0112301 W US0112301 W US 0112301W WO 0179232 A3 WO0179232 A3 WO 0179232A3
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WO
WIPO (PCT)
Prior art keywords
mpl
gene
haplotypes
mpl gene
disclosed
Prior art date
Application number
PCT/US2001/012301
Other languages
French (fr)
Other versions
WO2001079232A2 (en
Inventor
Anne Chew
Julie Y Choi
Beena Koshy
J Claiborne Stephens
Original Assignee
Genaissance Pharmaceuticals
Anne Chew
Julie Y Choi
Beena Koshy
J Claiborne Stephens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Anne Chew, Julie Y Choi, Beena Koshy, J Claiborne Stephens filed Critical Genaissance Pharmaceuticals
Priority to AU2001257056A priority Critical patent/AU2001257056A1/en
Publication of WO2001079232A2 publication Critical patent/WO2001079232A2/en
Publication of WO2001079232A3 publication Critical patent/WO2001079232A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel single nucleotide polymorphisms in the human myeloproliferative leukemia virus oncogene (MPL) gene are described. In addition, various genotypes, haplotypes and haplotype pairs for the MPL gene that exist in the population are described. Compositions and methods for haplotyping and/or genotyping the MPL gene in an individual are also disclosed. Polynucleotides containing one or more of the MPL polymorphisms disclosed herein are also described.
PCT/US2001/012301 2000-04-14 2001-04-16 Haplotypes of the mpl gene WO2001079232A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001257056A AU2001257056A1 (en) 2000-04-14 2001-04-16 Haplotypes of the mpl gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19783900P 2000-04-14 2000-04-14
US60/197,839 2000-04-14

Publications (2)

Publication Number Publication Date
WO2001079232A2 WO2001079232A2 (en) 2001-10-25
WO2001079232A3 true WO2001079232A3 (en) 2002-03-14

Family

ID=22730949

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/012301 WO2001079232A2 (en) 2000-04-14 2001-04-16 Haplotypes of the mpl gene

Country Status (2)

Country Link
AU (1) AU2001257056A1 (en)
WO (1) WO2001079232A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841074B2 (en) * 2009-12-04 2014-09-23 Quest Diagnostics Investments Incorporated MPL mutations in JAK2 V617F negative patients with myeloproliferative disease
WO2017004243A1 (en) 2015-06-29 2017-01-05 Caris Science, Inc. Therapeutic oligonucleotides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498599A (en) * 1994-01-21 1996-03-12 Amgen Inc. Methods for stimulating platelet production
US5989833A (en) * 1994-09-20 1999-11-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methods for detection of molecules with affinity for MPL polypeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498599A (en) * 1994-01-21 1996-03-12 Amgen Inc. Methods for stimulating platelet production
US5989833A (en) * 1994-09-20 1999-11-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methods for detection of molecules with affinity for MPL polypeptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] MIGNOTTE V. ET AL., XP002949616, accession no. NCBI Database accession no. U68159 *
DATABASE GENBANK XP002948093, Database accession no. U68160 *
DATABASE GENBANK XP002948094, Database accession no. U68162 *

Also Published As

Publication number Publication date
AU2001257056A1 (en) 2001-10-30
WO2001079232A2 (en) 2001-10-25

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