WO2001041832A3 - Systems and methods for performing frequent hemofiltration - Google Patents

Systems and methods for performing frequent hemofiltration Download PDF

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Publication number
WO2001041832A3
WO2001041832A3 PCT/US2000/042385 US0042385W WO0141832A3 WO 2001041832 A3 WO2001041832 A3 WO 2001041832A3 US 0042385 W US0042385 W US 0042385W WO 0141832 A3 WO0141832 A3 WO 0141832A3
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WO
WIPO (PCT)
Prior art keywords
hemofiltration
systems
machine
methods
fluid
Prior art date
Application number
PCT/US2000/042385
Other languages
French (fr)
Other versions
WO2001041832A2 (en
Inventor
Jeffrey H Burbank
James M Brugger
Dennis M Treu
C David Finch Jr
Barry N Fulkerson
Steven A White
Original Assignee
Nxstage Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Nxstage Medical Inc filed Critical Nxstage Medical Inc
Priority to AU45095/01A priority Critical patent/AU4509501A/en
Publication of WO2001041832A2 publication Critical patent/WO2001041832A2/en
Publication of WO2001041832A3 publication Critical patent/WO2001041832A3/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/367Circuit parts not covered by the preceding subgroups of group A61M1/3621
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3401Cassettes therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403Regulation parameters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403Regulation parameters
    • A61M1/341Regulation parameters by measuring the filtrate rate or volume
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3441Substitution rate control as a function of the ultrafiltration rate
    • A61M1/3444Substitution rate control as a function of the ultrafiltration rate in which the collected ultra-filtrate expels an equal volume of substitution fluid from a reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3607Regulation parameters
    • A61M1/3609Physical characteristics of the blood, e.g. haematocrit, urea
    • A61M1/361Physical characteristics of the blood, e.g. haematocrit, urea before treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M1/3607Regulation parameters
    • A61M1/3609Physical characteristics of the blood, e.g. haematocrit, urea
    • A61M1/3612Physical characteristics of the blood, e.g. haematocrit, urea after treatment
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    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36222Details related to the interface between cassette and machine
    • AHUMAN NECESSITIES
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    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36224Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with sensing means or components thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36225Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with blood pumping means or components thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226Constructional details of cassettes, e.g. specific details on material or shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362262Details of incorporated reservoirs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362265Details of valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3643Priming, rinsing before or after use
    • A61M1/3644Mode of operation
    • A61M1/3646Expelling the residual body fluid after use, e.g. back to the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362263Details of incorporated filters
    • A61M1/362264Details of incorporated filters the filter being a blood filter
    • AHUMAN NECESSITIES
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    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
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    • A61M1/3626Gas bubble detectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3639Blood pressure control, pressure transducers specially adapted therefor
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    • A61M2205/00General characteristics of the apparatus
    • A61M2205/12General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/125General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated filters
    • A61M2205/126General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated filters with incorporated membrane filters
    • AHUMAN NECESSITIES
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    • A61M2205/00General characteristics of the apparatus
    • A61M2205/12General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/128General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated valves
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    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3331Pressure; Flow
    • AHUMAN NECESSITIES
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    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3331Pressure; Flow
    • A61M2205/3334Measuring or controlling the flow rate
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    • A61M2205/35Communication
    • AHUMAN NECESSITIES
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    • A61M2205/00General characteristics of the apparatus
    • A61M2205/50General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502User interfaces, e.g. screens or keyboards
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    • A61M2205/50General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502User interfaces, e.g. screens or keyboards
    • A61M2205/505Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches

Abstract

Systems and methods support frequent hemofiltration at a designated treatment location (14) to provide a durable hemofiltration machine (16) at the site, and provide a disposable extracorporeal fluid circuit (18) for installation on the machine. The systems and methods provide a replacement fluid for connection to the extracorporeal fluid circuit. The systems and methods instruct use of the hemofiltration machine, extracorporeal fluid circuit, and replacement fluid at the site. Hemofiltration is carried out by (i) operating the hemofiltration machine to convey an individual's blood through the extracorporeal fluid circuit to a hemofilter at a blood flow rate of at least 300 ml/min to remove waste fluid, (ii) operating the hemofiltration machine to return treated blood, after removal of waste fluid, to the individual, and (iii) operating the hemofiltration machine to supply replacement fluid through the circuit to the individual, and (iv) performing (i), (ii), and (iii) at least four times weekly.
PCT/US2000/042385 1999-11-29 2000-11-29 Systems and methods for performing frequent hemofiltration WO2001041832A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU45095/01A AU4509501A (en) 1999-11-29 2000-11-29 Systems and methods for performing frequent hemofiltration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45123899A 1999-11-29 1999-11-29
US09/451,238 1999-11-29

Publications (2)

Publication Number Publication Date
WO2001041832A2 WO2001041832A2 (en) 2001-06-14
WO2001041832A3 true WO2001041832A3 (en) 2002-01-31

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ID=23791386

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/042385 WO2001041832A2 (en) 1999-11-29 2000-11-29 Systems and methods for performing frequent hemofiltration

Country Status (4)

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AT (1) ATE454917T1 (en)
AU (1) AU4509501A (en)
DE (1) DE60043710D1 (en)
WO (1) WO2001041832A2 (en)

Cited By (4)

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US8834719B2 (en) 2007-10-24 2014-09-16 Baxter International Inc. Personal hemodialysis system
US8858488B2 (en) 2003-11-05 2014-10-14 Baxter International Inc. Dialysis system including blood and dialysate cassette
US8882692B2 (en) 2003-11-05 2014-11-11 Baxter International Inc. Hemodialysis system with multiple cassette interference
US8920362B2 (en) 2007-07-05 2014-12-30 Baxter International Inc. Dialysis system having disposable cassette

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US7241272B2 (en) 2001-11-13 2007-07-10 Baxter International Inc. Method and composition for removing uremic toxins in dialysis processes
DE60336724D1 (en) 2002-07-19 2011-05-26 Baxter Healthcare Sa SYSTEM FOR PERITONEAL DIALYSIS
US9415150B2 (en) 2007-11-09 2016-08-16 Baxter Healthcare S.A. Balanced flow dialysis machine
US8057679B2 (en) 2008-07-09 2011-11-15 Baxter International Inc. Dialysis system having trending and alert generation
US8062513B2 (en) 2008-07-09 2011-11-22 Baxter International Inc. Dialysis system and machine having therapy prescription recall
EP3314488B1 (en) 2015-06-25 2024-03-13 Gambro Lundia AB Medical device system and method having a distributed database
US11516183B2 (en) 2016-12-21 2022-11-29 Gambro Lundia Ab Medical device system including information technology infrastructure having secure cluster domain supporting external domain
EP3505200B1 (en) 2017-12-29 2020-09-09 Gambro Lundia AB Apparatus for extracorporeal blood treatment

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US4650458A (en) * 1984-06-18 1987-03-17 Gambro Lundia Ab Apparatus for the measurement of fluid flow
US5762805A (en) * 1993-02-12 1998-06-09 Cobe Laboratories, Inc. Technique for extracorporeal treatment of blood
US5863421A (en) * 1995-02-13 1999-01-26 Aksys, Ltd. Hemodialysis machine with automatic priming by induced pressure pulses
US5871465A (en) * 1994-11-25 1999-02-16 I-Flow Corporation Remotely programmable infusion system

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
US4494950A (en) * 1982-01-19 1985-01-22 The Johns Hopkins University Plural module medication delivery system
US4650458A (en) * 1984-06-18 1987-03-17 Gambro Lundia Ab Apparatus for the measurement of fluid flow
US5762805A (en) * 1993-02-12 1998-06-09 Cobe Laboratories, Inc. Technique for extracorporeal treatment of blood
US5871465A (en) * 1994-11-25 1999-02-16 I-Flow Corporation Remotely programmable infusion system
US5863421A (en) * 1995-02-13 1999-01-26 Aksys, Ltd. Hemodialysis machine with automatic priming by induced pressure pulses

Cited By (20)

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Publication number Priority date Publication date Assignee Title
US9168333B2 (en) 2003-11-05 2015-10-27 Baxter International Inc. Dialysis system including disposable cassette
US9550020B2 (en) 2003-11-05 2017-01-24 Baxter International Inc. Dialysis system with a varying rate ultrafiltration profile
US8882692B2 (en) 2003-11-05 2014-11-11 Baxter International Inc. Hemodialysis system with multiple cassette interference
US8894600B2 (en) 2003-11-05 2014-11-25 Baxter International Inc. Hemodialysis system including on-line dialysate generation
US9144641B2 (en) 2003-11-05 2015-09-29 Baxter International Inc. Dialysis system with balance chamber prime and rinseback
US8926540B2 (en) 2003-11-05 2015-01-06 Baxter Healthcare Inc. Hemodialysis system with separate dialysate cassette
US9572919B2 (en) 2003-11-05 2017-02-21 Baxter International Inc. Dialysis system with cassette based balance chambers and volumetric pumps
US9155825B2 (en) 2003-11-05 2015-10-13 Baxter International Inc. Hemodialysis system using sorbent and reservoir
US9480784B2 (en) 2003-11-05 2016-11-01 Baxter International Inc. Dialysis system with balance chamber prime and rinseback
US8858488B2 (en) 2003-11-05 2014-10-14 Baxter International Inc. Dialysis system including blood and dialysate cassette
US9005152B2 (en) 2003-11-05 2015-04-14 Baxter International Inc. Dialysis system with cassette based balance chambers and volumetric pumps
US9216246B2 (en) 2003-11-05 2015-12-22 Baxter International Inc. Renal failure therapy machines and methods including conductive and convective clearance
US9302039B2 (en) 2003-11-05 2016-04-05 Baxter International Inc. Hemodialysis system including a disposable cassette
US9364602B2 (en) 2003-11-05 2016-06-14 Baxter International Inc. Systems and methods for priming sorbent-based hemodialysis using dialysis fluid
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AU4509501A (en) 2001-06-18
DE60043710D1 (en) 2010-03-04
WO2001041832A2 (en) 2001-06-14

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