WO2001021766A3 - Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells - Google Patents

Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells Download PDF

Info

Publication number
WO2001021766A3
WO2001021766A3 PCT/US2000/026020 US0026020W WO0121766A3 WO 2001021766 A3 WO2001021766 A3 WO 2001021766A3 US 0026020 W US0026020 W US 0026020W WO 0121766 A3 WO0121766 A3 WO 0121766A3
Authority
WO
WIPO (PCT)
Prior art keywords
hematopoietic
cells
methods
devices
obtaining non
Prior art date
Application number
PCT/US2000/026020
Other languages
French (fr)
Other versions
WO2001021766A2 (en
WO2001021766A8 (en
WO2001021766A9 (en
Inventor
Mark J Pykett
Michael Rosenzweig
Naheed Banu
Original Assignee
Cell Science Therapeutics
Mark J Pykett
Michael Rosenzweig
Naheed Banu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Science Therapeutics, Mark J Pykett, Michael Rosenzweig, Naheed Banu filed Critical Cell Science Therapeutics
Priority to AU76042/00A priority Critical patent/AU7604200A/en
Priority to EP00965306A priority patent/EP1218487A2/en
Publication of WO2001021766A2 publication Critical patent/WO2001021766A2/en
Publication of WO2001021766A8 publication Critical patent/WO2001021766A8/en
Publication of WO2001021766A3 publication Critical patent/WO2001021766A3/en
Publication of WO2001021766A9 publication Critical patent/WO2001021766A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells

Abstract

This invention pertains to hematopoietic cells, and more specifically to methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells. Non-hematopoietic lineage cells obtained by the foregoing methods of the invention are useful in the therapeutic treatment of a variety of pathologic conditions in humans and other species.
PCT/US2000/026020 1999-09-23 2000-09-22 Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells WO2001021766A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU76042/00A AU7604200A (en) 1999-09-23 2000-09-22 Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells
EP00965306A EP1218487A2 (en) 1999-09-23 2000-09-22 Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15603199P 1999-09-23 1999-09-23
US60/156,031 1999-09-23
US21743800P 2000-07-10 2000-07-10
US60/217,438 2000-07-10

Publications (4)

Publication Number Publication Date
WO2001021766A2 WO2001021766A2 (en) 2001-03-29
WO2001021766A8 WO2001021766A8 (en) 2001-05-10
WO2001021766A3 true WO2001021766A3 (en) 2001-06-28
WO2001021766A9 WO2001021766A9 (en) 2001-07-26

Family

ID=26852807

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/026020 WO2001021766A2 (en) 1999-09-23 2000-09-22 Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells

Country Status (2)

Country Link
EP (1) EP1218487A2 (en)
WO (1) WO2001021766A2 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440734B1 (en) 1998-09-25 2002-08-27 Cytomatrix, Llc Methods and devices for the long-term culture of hematopoietic progenitor cells
US6548299B1 (en) * 1999-11-12 2003-04-15 Mark J. Pykett Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices
ATE514772T1 (en) 1999-08-05 2011-07-15 Abt Holding Co MULTIPOTENT ADULT STEM CELLS AND METHOD FOR ISOLATION THEREOF
US10638734B2 (en) 2004-01-05 2020-05-05 Abt Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US8252280B1 (en) 1999-08-05 2012-08-28 Regents Of The University Of Minnesota MAPC generation of muscle
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US8609412B2 (en) 1999-08-05 2013-12-17 Regents Of The University Of Minnesota Mapc generation of lung tissue
US8075881B2 (en) 1999-08-05 2011-12-13 Regents Of The University Of Minnesota Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure
IL157332A0 (en) 2001-02-14 2004-02-19 Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
KR100449141B1 (en) * 2001-04-19 2004-09-21 (주)라이프코드 Method for differentiating a mesenchymal stem cell into neural cells
ES2180433B1 (en) * 2001-05-28 2004-05-16 Universidad Miguel Hernandez De Elche. EMPLOYMENT OF HEMATOPOYETIC MOTHER CELLS IN THE GENERATION OF NEURAL MOTHER CELLS.
JP2005512592A (en) 2001-12-21 2005-05-12 マウント・シナイ・ホスピタル Cellular composition, method for producing cellular composition, and method of using cellular composition
US7527968B2 (en) 2002-07-29 2009-05-05 Robarts Research Institute Regeneration initiating cells
US20060228798A1 (en) 2002-11-27 2006-10-12 Catherine Verfaillie Homologous recombination in multipotent adult progenitor cells
ES2571355T3 (en) 2002-12-16 2016-05-24 Technion Res & Dev Foundation Culture system without feeder cells or xenocontaminants for human embryonic stem cells
US8426200B2 (en) 2003-07-02 2013-04-23 Regents Of The University Of Minnesota Neuronal differentiation of stem cells
JP2009511061A (en) 2005-10-14 2009-03-19 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Differentiation of non-embryonic stem cells into cells with pancreatic phenotype
AU2007321928A1 (en) 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
WO2008070902A1 (en) * 2006-12-11 2008-06-19 Novozymes Biopharma Au Limited Tgf-beta compositions for treating infertility
ES2326772B1 (en) * 2007-09-26 2010-07-26 Fundacion Progreso Y Salud PROCESS FOR OBTAINING MESENQUIMAL MOTHER CELLS WITH PLURIPOTENT CAPACITY.
AU2009205886B2 (en) 2008-01-18 2015-08-27 Katholieke Universiteit Leuven Stem cell aggregates and methods for making and using
CA2728215A1 (en) 2008-06-18 2010-06-24 Innovative Biotherapies, Inc. Methods for enhanced propagation of cells
US9057051B2 (en) 2008-10-31 2015-06-16 Katholieke Universiteit Leuven Optimized methods for differentiation of cells into cells with hepatocyte progenitor phenotypes, cells produced by the methods, and methods of using the cells
CA3128483A1 (en) 2010-05-12 2011-11-17 Abt Holding Company Modulation of splenocytes in cell therapy
US9090878B2 (en) 2010-06-17 2015-07-28 Katholieke Universiteit Leuven Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells
AU2011293440B2 (en) 2010-08-24 2016-05-05 Katholieke Universiteit Leuven Non-static suspension culture of cell aggregates
WO2012048275A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
KR102161726B1 (en) 2013-04-12 2020-10-06 사베리오 라프란체스카 Improving organs for transplantation
JP6633522B2 (en) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド Cell growth in bioreactors
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
JP6830059B2 (en) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド Scheduled cell feeding
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017205667A1 (en) 2016-05-25 2017-11-30 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015629A1 (en) * 1997-09-25 1999-04-01 Cytomatrix, Llc Methods and devices for the long-term culture of hematopoietic progenitor cells
WO1999026644A1 (en) * 1997-11-26 1999-06-03 University Of Southern California Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
WO1999064565A2 (en) * 1998-06-08 1999-12-16 Osiris Therapeutics, Inc. Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells
WO2000017326A1 (en) * 1998-09-21 2000-03-30 Musc Foundation For Research Development Non-hematopoietic cells, including cardiomyocytes and skeletal muscle cells, derived from hematopoietic stem cells and methods of making and using them

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015629A1 (en) * 1997-09-25 1999-04-01 Cytomatrix, Llc Methods and devices for the long-term culture of hematopoietic progenitor cells
WO1999026644A1 (en) * 1997-11-26 1999-06-03 University Of Southern California Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
WO1999064565A2 (en) * 1998-06-08 1999-12-16 Osiris Therapeutics, Inc. Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells
WO2000017326A1 (en) * 1998-09-21 2000-03-30 Musc Foundation For Research Development Non-hematopoietic cells, including cardiomyocytes and skeletal muscle cells, derived from hematopoietic stem cells and methods of making and using them

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAGLEY J ET AL: "EXTENDED CULTURE OF MULTIPOTENT HEMATOPOIETIC PROGENITORS WITHOUT CYTOKINE AUGMENTATION IN A NOVEL THREE-DIMENSIONAL DEVICE", EXPERIMENTAL HEMATOLOGY,US,NEW YORK, NY, vol. 27, no. 3, March 1999 (1999-03-01), pages 496 - 504, XP000881139, ISSN: 0301-472X *
BANU N ET AL: "Neuronal, mesenchymal and hematopoietic cell derived from CD34-Lin- cell from adult bone marrow.", EXPERIMENTAL HEMATOLOGY (CHARLOTTESVILLE), vol. 28, no. 7 Supplement 1, July 2000 (2000-07-01), 29th Annual Meeting of the International Society for Experimental Hematology;Tampa, Florida, USA; July 08-11, 2000, pages 46 - 47, XP002163855, ISSN: 0301-472X *
BANU N ET AL: "Targeted differentiation of CD34+ progenitors in a three-dimensional matrix.", BLOOD, vol. 94, no. 10 SUPPL. 1 PART 2, 15 November 1999 (1999-11-15), Forty-first Annual Meeting of the American Society of Hematology;New Orleans, Louisiana, USA; December 3-7, 1999, pages 162b, XP000881148, ISSN: 0006-4971 *
CHENG L ET AL: "HUMAN MESENCHYMAL STEM CELLS SUPPORT PROLIFERATION AND MULTILINEAGE DIFFERENTIATION OF HUMAN HEMATOPOIETIC STEM CELLS", BLOOD,US,W.B. SAUNDERS, PHILADELPHIA, VA, vol. 92, no. 10, SUPPL. 01, 1998, pages 57A, XP000857628, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
WO2001021766A2 (en) 2001-03-29
EP1218487A2 (en) 2002-07-03
WO2001021766A8 (en) 2001-05-10
WO2001021766A9 (en) 2001-07-26

Similar Documents

Publication Publication Date Title
WO2001021766A8 (en) Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells
WO2002030358A3 (en) Modulation of ccr4 function
WO2001016114A3 (en) Heterocyclic compounds and methods for modulating cxcr3 function
HK1045852A1 (en) Polyurethane solutions containing alkoxysilane structural units
WO2005063971A3 (en) Definitive endoderm
WO2004108133A3 (en) Modulators of vr1 receptor
MY142777A (en) Substituted indole-o-glucosides
UA86042C2 (en) Substituted indazole-o-glucosides
WO2004006667A3 (en) Methods for the regeneration and transformation of cotton
YU19499A (en) Benzonaphthyridines as bronchial therapeutics
WO2004093817A3 (en) Chemokine receptor binding heterocyclic compounds with enhanced efficacy
WO2001005355A3 (en) Formulations for il-11
WO2004006834A3 (en) Leflunomide analogs for treating rheumatoid arthritis
WO2000066528A3 (en) Quinones for treatment of diseases
WO2003075953A3 (en) Immunomodulatory polymeric antigens for treating inflammatory pathogies
WO2002030357A3 (en) Compounds and methods for modulating ccr4 function
WO2001076369A3 (en) Active substance combinations having insecticidal and acaricidal properties
WO2001079164A3 (en) N-substituted dithiocarbamates for the treatment of biological disorders
GB0003025D0 (en) Novel compounds
WO2001040177A3 (en) Esters of vitamin d3 and uses thereof
WO2004099388A3 (en) Cbl-b polypeptides, complexes and related methods
EP1946767A3 (en) Autologous T-cell vaccines against multiple sclerosis
MY127675A (en) Substituted 3-pyridyl-4-arylpyrroles, and related therapeutic and prophylactic methods
AU2001283199A1 (en) Methods and compositions for the diagnosis and treatment of brown adipose cell disorders
SI1244643T1 (en) Tryptase inhibitors

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA CN JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: C1

Designated state(s): AU CA CN JP US

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: PAT. BUL. 13/2001 UNDER (30) REPLACE "60/127438" BY "60/217438"

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA CN JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: C2

Designated state(s): AU CA CN JP US

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

COP Corrected version of pamphlet

Free format text: PAGES 1/3-3/3, DRAWINGS, REPLACED BY NEW PAGES 1/4-4/4; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2000965306

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000965306

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2000965306

Country of ref document: EP