WO2001000643A3 - Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase - Google Patents

Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase Download PDF

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Publication number
WO2001000643A3
WO2001000643A3 PCT/IL2000/000358 IL0000358W WO0100643A3 WO 2001000643 A3 WO2001000643 A3 WO 2001000643A3 IL 0000358 W IL0000358 W IL 0000358W WO 0100643 A3 WO0100643 A3 WO 0100643A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotides
heparanase
polypeptides encoded
recombinant proteins
distantly homologous
Prior art date
Application number
PCT/IL2000/000358
Other languages
French (fr)
Other versions
WO2001000643A2 (en
Inventor
Iris Pecker
Israel Michal
Hanan Itzhaki
Original Assignee
Insight Strategy & Marketing
Iris Pecker
Israel Michal
Hanan Itzhaki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU0300901A priority Critical patent/HUP0300901A2/en
Application filed by Insight Strategy & Marketing, Iris Pecker, Israel Michal, Hanan Itzhaki filed Critical Insight Strategy & Marketing
Priority to AU52448/00A priority patent/AU777343B2/en
Priority to CA002377498A priority patent/CA2377498A1/en
Priority to MXPA01011708A priority patent/MXPA01011708A/en
Priority to US09/959,643 priority patent/US7101706B1/en
Priority to KR1020017016406A priority patent/KR20020028906A/en
Priority to JP2001507050A priority patent/JP2003503070A/en
Priority to IL14652700A priority patent/IL146527A0/en
Priority to EP00937164A priority patent/EP1212341A4/en
Publication of WO2001000643A2 publication Critical patent/WO2001000643A2/en
Priority to NO20015526A priority patent/NO20015526L/en
Priority to IL146527A priority patent/IL146527A/en
Publication of WO2001000643A3 publication Critical patent/WO2001000643A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01166—Heparanase (3.2.1.166)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)

Abstract

Novel polynucleotides encoding polypeptides distantly homologous to heparanase, nucleic acid constructs including the polynucleotides, genetically modified cells expressing same, recombinant proteins encoded thereby and which may have heparanase or other glycosyl hydrolase activity, antibodies recognizing the recombinant proteins, oligonucleotides and oligonucleotide analogs derived from the polynucleotides and ribozymes including same.
PCT/IL2000/000358 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase WO2001000643A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
KR1020017016406A KR20020028906A (en) 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase
AU52448/00A AU777343B2 (en) 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase
CA002377498A CA2377498A1 (en) 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase
MXPA01011708A MXPA01011708A (en) 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase.
US09/959,643 US7101706B1 (en) 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase
HU0300901A HUP0300901A2 (en) 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase
JP2001507050A JP2003503070A (en) 1999-06-25 2000-06-19 Polynucleotides with distant homology to heparanase and polypeptides encoded thereby
IL14652700A IL146527A0 (en) 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homolgous to heparanse
EP00937164A EP1212341A4 (en) 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase
NO20015526A NO20015526L (en) 1999-06-25 2001-11-12 Polynucleotides and polypeptides encoded by these, distantly homologous to heparanase
IL146527A IL146527A (en) 1999-06-25 2001-11-15 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14080199P 1999-06-25 1999-06-25
US60/140,801 1999-06-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/938,661 Continuation US20050070000A1 (en) 1999-06-25 2004-09-13 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase

Publications (2)

Publication Number Publication Date
WO2001000643A2 WO2001000643A2 (en) 2001-01-04
WO2001000643A3 true WO2001000643A3 (en) 2005-02-24

Family

ID=22492846

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2000/000358 WO2001000643A2 (en) 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase

Country Status (12)

Country Link
EP (1) EP1212341A4 (en)
JP (1) JP2003503070A (en)
KR (1) KR20020028906A (en)
CN (1) CN1370178A (en)
AU (1) AU777343B2 (en)
CA (1) CA2377498A1 (en)
HU (1) HUP0300901A2 (en)
IL (1) IL146527A0 (en)
MX (1) MXPA01011708A (en)
NO (1) NO20015526L (en)
PL (1) PL362599A1 (en)
WO (1) WO2001000643A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1157118A4 (en) * 1999-03-01 2002-07-17 Insight Strategy & Marketing Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
EP1214423A1 (en) * 1999-09-23 2002-06-19 MERCK PATENT GmbH Heparanase-2, a member of the heparanase protein family
CA2393855A1 (en) * 1999-12-22 2001-06-28 Oxford Glycosciences (Uk) Ltd. Homologues of human heparanase and splice variants thereof
KR20020062375A (en) * 1999-12-23 2002-07-25 쉐링 악티엔게젤샤프트 Human Heparanase-Related Polypeptide and Nucleic Acid
GB0014447D0 (en) * 2000-06-13 2000-08-09 Smithkline Beecham Plc Novel compounds
AU2001287610A1 (en) * 2000-07-12 2002-01-21 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw A second human heparanase, and splice variants thereof, with a predominant expression in skeletal muscle, heart and pancreas
IL162276A0 (en) * 2004-06-01 2005-11-20 Hadasit Med Res Service Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof
FI20085308A0 (en) * 2008-04-11 2008-04-11 Polysackaridforskning I Uppsal Heparanase-free non-human mammals
JP5622451B2 (en) * 2010-06-21 2014-11-12 小川香料株式会社 Tea extract
JP6321506B2 (en) * 2014-09-22 2018-05-09 株式会社 資生堂 Whitening method with heparanase inhibitor and method for evaluating substances having whitening effect
CN116064544A (en) * 2016-01-26 2023-05-05 日产化学株式会社 Single-stranded oligonucleotides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
CA2307830A1 (en) * 1997-10-28 1999-05-06 The Australian National University Isolated nucleic acid molecule encoding mammalian endoglucuronidase and uses therefor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE GEN.BANK [online] 30 November 1998 (1998-11-30), NCI-CGAP, NATIONAL CANCER INSTITUTE, XP002155607, Database accession no. AI222323 *

Also Published As

Publication number Publication date
HUP0300901A2 (en) 2003-07-28
KR20020028906A (en) 2002-04-17
CA2377498A1 (en) 2001-01-04
IL146527A0 (en) 2002-07-25
MXPA01011708A (en) 2003-09-10
NO20015526L (en) 2001-12-18
NO20015526D0 (en) 2001-11-12
EP1212341A4 (en) 2002-11-27
WO2001000643A2 (en) 2001-01-04
CN1370178A (en) 2002-09-18
AU777343B2 (en) 2004-10-14
EP1212341A1 (en) 2002-06-12
AU5244800A (en) 2001-01-31
JP2003503070A (en) 2003-01-28
PL362599A1 (en) 2004-11-02

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