WO2001000187A3 - Pharmaceutical composition containing sibutramine and a lipase inhibitor - Google Patents

Pharmaceutical composition containing sibutramine and a lipase inhibitor Download PDF

Info

Publication number
WO2001000187A3
WO2001000187A3 PCT/EP2000/005544 EP0005544W WO0100187A3 WO 2001000187 A3 WO2001000187 A3 WO 2001000187A3 EP 0005544 W EP0005544 W EP 0005544W WO 0100187 A3 WO0100187 A3 WO 0100187A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipase inhibitor
pharmaceutical composition
composition containing
containing sibutramine
human
Prior art date
Application number
PCT/EP2000/005544
Other languages
French (fr)
Other versions
WO2001000187A2 (en
Inventor
Alan Martin Birch
David John Heal
Original Assignee
Knoll Ag
Alan Martin Birch
David John Heal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002376213A priority Critical patent/CA2376213A1/en
Priority to AU58151/00A priority patent/AU5815100A/en
Priority to IL14707800A priority patent/IL147078A0/en
Priority to BR0011884-2A priority patent/BR0011884A/en
Application filed by Knoll Ag, Alan Martin Birch, David John Heal filed Critical Knoll Ag
Priority to EP00943819A priority patent/EP1189638A2/en
Priority to JP2001505897A priority patent/JP2003503344A/en
Priority to MXPA01013023A priority patent/MXPA01013023A/en
Priority to KR1020017016577A priority patent/KR20020012293A/en
Priority to HU0201880A priority patent/HUP0201880A3/en
Priority to SK1882-2001A priority patent/SK18822001A3/en
Publication of WO2001000187A2 publication Critical patent/WO2001000187A2/en
Publication of WO2001000187A3 publication Critical patent/WO2001000187A3/en
Priority to BG06209A priority patent/BG106209A/en
Priority to NO20016301A priority patent/NO20016301L/en
Priority to HK03101311.7A priority patent/HK1050476A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Abstract

A method for the treatment of obesity and associated co-morbid conditions in a human in need of such treatment which comprises administration to the human of a therapeutically effective amount of a compound of formula (I), including enantiomers and pharmaceutically acceptable salts thereof, in which R1 and R2 are independently H or methyl, and a therapeutically effective amount of a lipase inhibitor with the exception of orlistat; wherein the compound of formula (I) and the lipase inhibitor are administered simultaneously, separately or sequentially.
PCT/EP2000/005544 1999-06-24 2000-06-16 Pharmaceutical composition containing sibutramine and a lipase inhibitor WO2001000187A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP2001505897A JP2003503344A (en) 1999-06-24 2000-06-16 Remedies
IL14707800A IL147078A0 (en) 1999-06-24 2000-06-16 Therapeutic agents
BR0011884-2A BR0011884A (en) 1999-06-24 2000-06-16 Method of treating obesity and comorbid conditions in a human in need of such treatment, compound of formula i, product containing compound of formula i, use of compound of formula i, and pharmaceutical composition
KR1020017016577A KR20020012293A (en) 1999-06-24 2000-06-16 Therapeutic Agents
EP00943819A EP1189638A2 (en) 1999-06-24 2000-06-16 Pharmaceutical composition containing sibutramine and a lipase inhibitor
AU58151/00A AU5815100A (en) 1999-06-24 2000-06-16 Therapeutic agents
MXPA01013023A MXPA01013023A (en) 1999-06-24 2000-06-16 Therapeutic agents.
CA002376213A CA2376213A1 (en) 1999-06-24 2000-06-16 Therapeutic agents
HU0201880A HUP0201880A3 (en) 1999-06-24 2000-06-16 Pharmaceutical composition containing sibutramine and a lipase inhibitor
SK1882-2001A SK18822001A3 (en) 1999-06-24 2000-06-16 Therapeutic agents
BG06209A BG106209A (en) 1999-06-24 2001-12-11 Therapeutic agents
NO20016301A NO20016301L (en) 1999-06-24 2001-12-21 Therapeutic agents
HK03101311.7A HK1050476A1 (en) 1999-06-24 2003-02-20 Pharmaceutical composition containing sibutramine and a lipase inhibitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9914742.3 1999-06-24
GBGB9914742.3A GB9914742D0 (en) 1999-06-24 1999-06-24 Therapeutic agents

Publications (2)

Publication Number Publication Date
WO2001000187A2 WO2001000187A2 (en) 2001-01-04
WO2001000187A3 true WO2001000187A3 (en) 2001-11-15

Family

ID=10855953

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/005544 WO2001000187A2 (en) 1999-06-24 2000-06-16 Pharmaceutical composition containing sibutramine and a lipase inhibitor

Country Status (20)

Country Link
EP (1) EP1189638A2 (en)
JP (1) JP2003503344A (en)
KR (1) KR20020012293A (en)
CN (1) CN1365287A (en)
AU (1) AU5815100A (en)
BG (1) BG106209A (en)
BR (1) BR0011884A (en)
CA (1) CA2376213A1 (en)
CZ (1) CZ20014614A3 (en)
GB (1) GB9914742D0 (en)
HK (1) HK1050476A1 (en)
HU (1) HUP0201880A3 (en)
IL (1) IL147078A0 (en)
MX (1) MXPA01013023A (en)
NO (1) NO20016301L (en)
PL (1) PL352387A1 (en)
SK (1) SK18822001A3 (en)
TR (1) TR200103704T2 (en)
WO (1) WO2001000187A2 (en)
ZA (1) ZA200110046B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399826B1 (en) * 1999-08-11 2002-06-04 Sepracor Inc. Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
US7089666B2 (en) * 2003-06-06 2006-08-15 The Regents Of The University Of California Microfabricated vertical comb actuator using plastic deformation
US8604244B2 (en) 2010-07-02 2013-12-10 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
EP2066329B1 (en) 2006-09-15 2017-09-06 Reviva Pharmaceuticals, Inc. Synthesis, methods of using, and compositions of cyclobutylmethylamines
CN101890017A (en) * 2009-05-22 2010-11-24 北京奥萨医药研究中心有限公司 Medicament composition containing sibutramine and stanin fat-reducing medicament and application thereof
US9238625B2 (en) 2011-12-30 2016-01-19 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BUTTLE L.A.: "Anti-obesity drugs: On target for huge market sales", EXPERT OPINION ON INVESTIGATIONAL DRUGS(EXPERT OPIN. INVEST. DRUGS), 5/12 (1583-1587), United Kingdom, XP002105328 *

Also Published As

Publication number Publication date
MXPA01013023A (en) 2003-08-01
CZ20014614A3 (en) 2004-02-18
BR0011884A (en) 2003-08-12
ZA200110046B (en) 2003-03-06
CA2376213A1 (en) 2001-01-04
TR200103704T2 (en) 2002-05-21
HUP0201880A3 (en) 2003-03-28
BG106209A (en) 2002-09-30
SK18822001A3 (en) 2003-04-01
PL352387A1 (en) 2003-08-25
AU5815100A (en) 2001-01-31
WO2001000187A2 (en) 2001-01-04
EP1189638A2 (en) 2002-03-27
NO20016301D0 (en) 2001-12-21
KR20020012293A (en) 2002-02-15
GB9914742D0 (en) 1999-08-25
IL147078A0 (en) 2002-08-14
JP2003503344A (en) 2003-01-28
CN1365287A (en) 2002-08-21
HK1050476A1 (en) 2003-06-27
NO20016301L (en) 2001-12-21
HUP0201880A2 (en) 2002-12-28

Similar Documents

Publication Publication Date Title
WO2003000343A3 (en) Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
AU2003225617A1 (en) Thiadiazolylpiperazine derivatives useful for treating or preventing pain
AU7031500A (en) Therapeutic quinazoline compounds
NZ514574A (en) Novel method of treatment
GB2254784B (en) Film-coated solid dosage form of anti-migraine drug
GEP20043269B (en) Purine Derivatives, Method for Their Production and Composition Containing the Same
GEP20043324B (en) Purine Derivatives
FI973163A (en) Treatment of incontinence using (S) -oxybutynin and (S) -desethyloxybutynin
WO1999033450A3 (en) Pharmaceutical composition containing sibutramine and orlistat
AU3850600A (en) Dalda analogs and their use
WO2000071108A3 (en) Methods for treatment of asthma using s-oxybutynin
MXPA01012936A (en) Pharmaceutical composition containing sibutramine and orlistat.
WO2001000187A3 (en) Pharmaceutical composition containing sibutramine and a lipase inhibitor
AU2420001A (en) Methods and compositions for the treatment of pain
WO2005055933A3 (en) Treatment of psoriasis with rosiglitazone
MY133438A (en) Morpholinobenzamide salts
AP9801235A0 (en) Erythromycin derivatives.
SE9800905D0 (en) New therapy in glomerulonephritis
WO2002041841A3 (en) Compositions for adhesion prevention
WO2004073627A3 (en) Novel therapeutic method and compositions for topical administration
WO2005035500A3 (en) Therapeutic agents useful for treating pain
WO1999033454A3 (en) S-procyclidine for treating urinary incontinence
WO2004050019A9 (en) Method and compositions for treating anxiety
WO2003004019A8 (en) Use of heterocyclic and benzoheterocyclic polyamides structurally related to the natural antibiotic distamycin a for the treatment of beta-thalassaemia
WO1999033453A3 (en) R-procyclidine for treating urinary incontinence

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 200110046

Country of ref document: ZA

ENP Entry into the national phase

Ref document number: 2000 106209

Country of ref document: BG

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2376213

Country of ref document: CA

Ref document number: 2376213

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 516141

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/013023

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: PV2001-4614

Country of ref document: CZ

WWE Wipo information: entry into national phase

Ref document number: 58151/00

Country of ref document: AU

Ref document number: 18822001

Country of ref document: SK

ENP Entry into the national phase

Ref document number: 2001 505897

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: IN/PCT/2001/1796/CHE

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 1020017016577

Country of ref document: KR

Ref document number: 2001/03704

Country of ref document: TR

WWE Wipo information: entry into national phase

Ref document number: 2000943819

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 008105448

Country of ref document: CN

ENP Entry into the national phase

Ref document number: 2002 2002102075

Country of ref document: RU

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: P20020067A

Country of ref document: HR

WWP Wipo information: published in national office

Ref document number: 1020017016577

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 2000943819

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10009843

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2000943819

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: PV2001-4614

Country of ref document: CZ

WWR Wipo information: refused in national office

Ref document number: 1020017016577

Country of ref document: KR

WWR Wipo information: refused in national office

Ref document number: PV2001-4614

Country of ref document: CZ