WO2000040532A3 - Synthesis of dihydrohonokiol compositions - Google Patents

Synthesis of dihydrohonokiol compositions Download PDF

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Publication number
WO2000040532A3
WO2000040532A3 PCT/US1999/030168 US9930168W WO0040532A3 WO 2000040532 A3 WO2000040532 A3 WO 2000040532A3 US 9930168 W US9930168 W US 9930168W WO 0040532 A3 WO0040532 A3 WO 0040532A3
Authority
WO
WIPO (PCT)
Prior art keywords
dihydrohonokiol
synthesis
compositions
disclosed
homologs
Prior art date
Application number
PCT/US1999/030168
Other languages
French (fr)
Other versions
WO2000040532A2 (en
Inventor
William B Stavinoha
Neera Satsangi
Rajiv K Satsangi
Original Assignee
Univ Texas
William B Stavinoha
Neera Satsangi
Rajiv K Satsangi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, William B Stavinoha, Neera Satsangi, Rajiv K Satsangi filed Critical Univ Texas
Priority to AU25899/00A priority Critical patent/AU2589900A/en
Priority to EP99968495A priority patent/EP1140756A2/en
Priority to CA002358554A priority patent/CA2358554A1/en
Publication of WO2000040532A2 publication Critical patent/WO2000040532A2/en
Publication of WO2000040532A3 publication Critical patent/WO2000040532A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The synthesis and use of the anxiolytic compound dihydrohonokiol, its derivatives, analogs and homologs are disclosed. A method for reducing anxiety in a mammal is also disclosed.
PCT/US1999/030168 1998-12-31 1999-12-17 Synthesis of dihydrohonokiol compositions WO2000040532A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU25899/00A AU2589900A (en) 1998-12-31 1999-12-17 Synthesis of dihydrohonokiol compositions
EP99968495A EP1140756A2 (en) 1998-12-31 1999-12-17 Synthesis of dihydrohonokiol compositions
CA002358554A CA2358554A1 (en) 1998-12-31 1999-12-17 Synthesis of dihydrohonokiol compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22418898A 1998-12-31 1998-12-31
US09/224,188 1998-12-31

Publications (2)

Publication Number Publication Date
WO2000040532A2 WO2000040532A2 (en) 2000-07-13
WO2000040532A3 true WO2000040532A3 (en) 2000-11-16

Family

ID=22839629

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/030168 WO2000040532A2 (en) 1998-12-31 1999-12-17 Synthesis of dihydrohonokiol compositions

Country Status (4)

Country Link
EP (1) EP1140756A2 (en)
AU (1) AU2589900A (en)
CA (1) CA2358554A1 (en)
WO (1) WO2000040532A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2423181A1 (en) 2010-07-28 2012-02-29 Prous Institute For Biomedical Research S.A. Multitarget substituted biphenyl diol derivatives
EP2986587B1 (en) 2013-04-17 2023-11-22 Sharon Anavi-Goffer Cb2 receptor ligands for the treatment of psychiatric disorders
EP3307254B1 (en) * 2015-06-11 2020-08-05 The Medical College of Wisconsin, Inc. Mito-honokiol compounds and methods of synthesis and use thereof
US11897910B2 (en) 2015-06-11 2024-02-13 The Medical College Of Wisconsin, Inc. Mito-honokiol compounds and methods of synthesis and use thereof
CN108430463B (en) 2015-10-23 2021-01-29 高露洁-棕榄公司 Improved synthesis of honokiol
WO2021026285A1 (en) * 2019-08-06 2021-02-11 Kirkland Justin Formulations including dihydrohonokiol
WO2022160065A1 (en) * 2021-01-31 2022-08-04 Betterlife Pharma Inc. Formulations including dihydrohonokiol

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139335A (en) * 1983-01-31 1984-08-10 Tsumura Juntendo Inc Novel hydroxybiphenyl compound
EP0382213A2 (en) * 1989-02-08 1990-08-16 Otsuka Pharmaceutical Co., Ltd. Biphenyl derivative, nerve cell degeneration repairing or protecting agent and process for preparing a phenyl derivative contained in the agent
JPH072655A (en) * 1993-06-18 1995-01-06 Otsuka Pharmaceut Co Ltd Agent for repairing or protecting denaturation of peripheral nerve
WO1999000346A1 (en) * 1997-06-26 1999-01-07 Board Of Regents, The University Of Texas System Synthesis of dihydrohonokiol compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139335A (en) * 1983-01-31 1984-08-10 Tsumura Juntendo Inc Novel hydroxybiphenyl compound
EP0382213A2 (en) * 1989-02-08 1990-08-16 Otsuka Pharmaceutical Co., Ltd. Biphenyl derivative, nerve cell degeneration repairing or protecting agent and process for preparing a phenyl derivative contained in the agent
JPH072655A (en) * 1993-06-18 1995-01-06 Otsuka Pharmaceut Co Ltd Agent for repairing or protecting denaturation of peripheral nerve
WO1999000346A1 (en) * 1997-06-26 1999-01-07 Board Of Regents, The University Of Texas System Synthesis of dihydrohonokiol compositions

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEM. PHARM. BULL., vol. 35, no. 5, 1987, pages 1762 - 1769 *
CHEM. PHARM. BULL., vol. 39, no. 8, 1991, pages 2024 - 2036 *
CHEMICAL ABSTRACTS, vol. 108, no. 9, 29 February 1988, Columbus, Ohio, US; abstract no. 74902r, TAKEYA T ET AL: "Synthesis of biphenyls by acid-catalyzed condensation reactions of 1-oxaspiro(4.5)-deca-6,9-diene-2,8-dione with phenols or phenol ethers" page 633; column 1; XP002901052 *
CHEMICAL ABSTRACTS, vol. 116, no. 8, 24 February 1992, Columbus, Ohio, US; abstract no. 67005n, YAHARA S ET AL: "Isolation and characterization of phenolic compounds from magnoliae cortex produced in China" page 492; column 1; XP002901051 *
PATENT ABSTRACTS OF JAPAN vol. 008, no. 260 (C - 254) 29 November 1984 (1984-11-29) *
PATENT ABSTRACTS OF JAPAN vol. 1995, no. 04 31 May 1995 (1995-05-31) *

Also Published As

Publication number Publication date
WO2000040532A2 (en) 2000-07-13
AU2589900A (en) 2000-07-24
CA2358554A1 (en) 2000-07-13
EP1140756A2 (en) 2001-10-10

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