WO2000009655A3 - Genes amplified in cancer cells - Google Patents
Genes amplified in cancer cells Download PDFInfo
- Publication number
- WO2000009655A3 WO2000009655A3 PCT/US1999/018101 US9918101W WO0009655A3 WO 2000009655 A3 WO2000009655 A3 WO 2000009655A3 US 9918101 W US9918101 W US 9918101W WO 0009655 A3 WO0009655 A3 WO 0009655A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cancer
- genes
- rna
- cells
- gene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
New methods are disclosed for detecting cancer associated genes, and obtaining corresponding cDNA sequences. The methods involve displaying cDNA from control cells, and from a plurality of different cancer cells that share a duplicated or deleted gene in the same region of a chromosome. Four novel genes associated with cancer have been identified. In at least about 60% of the breast cancer cell lines tested, RNA hybridizing with the cDNAs were substantially more abundant than in normal cells. Many of the cell lines also showed a duplication of the corresponding gene, which probably contributed to the increased level of RNA in the cell. However, for each of the four genes, there were some cell lines which had RNA overabundance without gene duplication. This suggests that the gene product is sufficiently important to the cancer process that cells will use several alternative mechanisms to achieve increased expression. One of the protein products is predicted to be a membrane protein, another is predicted to have DNA or RNA binding activity. Several of the genes share conserved regions with distantly related organisms, suggesting a fundamental role in cellular metabolism or proliferation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU54748/99A AU5474899A (en) | 1998-08-10 | 1999-08-10 | Genes amplified in cancer cells |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13202998A | 1998-08-10 | 1998-08-10 | |
| US09/132,029 | 1998-08-10 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2000009655A2 WO2000009655A2 (en) | 2000-02-24 |
| WO2000009655A3 true WO2000009655A3 (en) | 2000-05-18 |
| WO2000009655A9 WO2000009655A9 (en) | 2000-11-09 |
Family
ID=22452121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1999/018101 WO2000009655A2 (en) | 1998-08-10 | 1999-08-10 | Genes amplified in cancer cells |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU5474899A (en) |
| WO (1) | WO2000009655A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1702928A3 (en) * | 2000-06-02 | 2006-09-27 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20030120040A1 (en) | 2001-06-29 | 2003-06-26 | Genentech, Inc. | Secreted and Transmembrane polypeptides and nucleic acids encoding the same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995005392A1 (en) * | 1993-08-12 | 1995-02-23 | Board Of Regents, The University Of Texas System | Novel proteins which bind to retinoblastoma protein and their encoding dna sequences |
| US5710001A (en) * | 1994-08-12 | 1998-01-20 | Myriad Genetics, Inc. | 17q-linked breast and ovarian cancer susceptibility gene |
| US5795726A (en) * | 1996-11-12 | 1998-08-18 | Millennium Pharmaceuticals, Inc. | Methods for identifying compounds useful in treating type II diabetes |
-
1999
- 1999-08-10 WO PCT/US1999/018101 patent/WO2000009655A2/en active Application Filing
- 1999-08-10 AU AU54748/99A patent/AU5474899A/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995005392A1 (en) * | 1993-08-12 | 1995-02-23 | Board Of Regents, The University Of Texas System | Novel proteins which bind to retinoblastoma protein and their encoding dna sequences |
| US5710001A (en) * | 1994-08-12 | 1998-01-20 | Myriad Genetics, Inc. | 17q-linked breast and ovarian cancer susceptibility gene |
| US5795726A (en) * | 1996-11-12 | 1998-08-18 | Millennium Pharmaceuticals, Inc. | Methods for identifying compounds useful in treating type II diabetes |
Non-Patent Citations (8)
| Title |
|---|
| CELL, vol. 85, no. 6, 1996, pages 829 - 839 * |
| DATABASE GENEBANK UNIVERSITY TEXAS SYSTEM: "p48 and p46 retinoblastoma binding proteins and corresponding DNA bind to Rb competitively with the SV40 T antigen; for the control, diagnosis and research of cancers" * |
| DATABASE GENEBANK111 19 June 1996 (1996-06-19), KIPREOS ET AL.: "Cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family" * |
| DATABASE GENEBANK111 24 November 1997 (1997-11-24), FAN J.: "Human Chromosome 1BAC 30861 Genomic Sequence" * |
| DATABASE GENEBANK111 27 March 1998 (1998-03-27), NCI-CGAP: "National Cancer Institute, Cancer Genome Anatomy Project (CGAP)" * |
| DATABASE GENEBANK111 3 June 1997 (1997-06-03), WILKINSON J.: "Direct Submission" * |
| DATABASE GENESEQ35 3 May 1994 (1994-05-03), CHERET ET AL.: "Direct Submission" * |
| PINKEL ET AL.: "Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization", PROC. NATL. ACAD. SCI. USA, vol. 83, May 1986 (1986-05-01), pages 2934 - 2938, XP002900461 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU5474899A (en) | 2000-03-06 |
| WO2000009655A9 (en) | 2000-11-09 |
| WO2000009655A2 (en) | 2000-02-24 |
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