WO1999062908A3 - Cell adhesion-inhibiting antinflammatory compounds - Google Patents

Cell adhesion-inhibiting antinflammatory compounds Download PDF

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Publication number
WO1999062908A3
WO1999062908A3 PCT/US1999/012419 US9912419W WO9962908A3 WO 1999062908 A3 WO1999062908 A3 WO 1999062908A3 US 9912419 W US9912419 W US 9912419W WO 9962908 A3 WO9962908 A3 WO 9962908A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibiting
cell adhesion
compounds
antinflammatory
antinflammatory compounds
Prior art date
Application number
PCT/US1999/012419
Other languages
French (fr)
Other versions
WO1999062908A2 (en
Inventor
Andrew O Stewart
Steven A Boyd
David L Arendsen
Pramila Bhatia
Kevin R Condroski
Jennifer C Freeman
Indrani W Gunawardana
Gui-Dong Zhu
Kraig Lartey
Catherine M Mccarty
Nicholas A Mort
Meena V Patel
Michael A Staeger
David M Stout
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU42312/99A priority Critical patent/AU4231299A/en
Priority to BR9910864-0A priority patent/BR9910864A/en
Priority to CA002333770A priority patent/CA2333770A1/en
Priority to EP99926157A priority patent/EP1090009A2/en
Priority to JP2000552119A priority patent/JP2002517396A/en
Priority to SK1854-2000A priority patent/SK18542000A3/en
Priority to PL99345906A priority patent/PL345906A1/en
Priority to KR1020007013739A priority patent/KR20010052570A/en
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to IL13981199A priority patent/IL139811A0/en
Priority to HU0102366A priority patent/HUP0102366A2/en
Publication of WO1999062908A2 publication Critical patent/WO1999062908A2/en
Publication of WO1999062908A3 publication Critical patent/WO1999062908A3/en
Priority to NO20006157A priority patent/NO20006157L/en
Priority to BG105109A priority patent/BG105109A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
PCT/US1999/012419 1998-06-04 1999-06-03 Cell adhesion-inhibiting antinflammatory compounds WO1999062908A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
PL99345906A PL345906A1 (en) 1998-06-04 1999-06-03 Cell adhesion-inhibiting antinflammatory compounds
CA002333770A CA2333770A1 (en) 1998-06-04 1999-06-03 Cell adhesion-inhibiting antinflammatory compounds
EP99926157A EP1090009A2 (en) 1998-06-04 1999-06-03 Cell adhesion-inhibiting antinflammatory compounds
JP2000552119A JP2002517396A (en) 1998-06-04 1999-06-03 Anti-inflammatory compounds that inhibit cell adhesion
SK1854-2000A SK18542000A3 (en) 1998-06-04 1999-06-03 Cell adhesion-inhibiting anti-inflammatory compounds
AU42312/99A AU4231299A (en) 1998-06-04 1999-06-03 Cell adhesion-inhibiting antinflammatory compounds
KR1020007013739A KR20010052570A (en) 1998-06-04 1999-06-03 Cell adhesion-inhibiting antiinflammatory compounds
BR9910864-0A BR9910864A (en) 1998-06-04 1999-06-03 Anti-inflammatory compounds for inhibiting cell adhesion
IL13981199A IL139811A0 (en) 1998-06-04 1999-06-03 Cell adhesion-inhibiting antinflammatory compounds
HU0102366A HUP0102366A2 (en) 1998-06-04 1999-06-03 Cell adhesion-inhibiting antinflammatory compounds
NO20006157A NO20006157L (en) 1998-06-04 2000-12-04 Cell adhesion inhibiting anti-inflammatory compounds
BG105109A BG105109A (en) 1998-06-04 2001-01-03 Cell adhesion-inhibiting anti-inflammatory compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9070198A 1998-06-04 1998-06-04
US09/090,701 1998-06-04

Publications (2)

Publication Number Publication Date
WO1999062908A2 WO1999062908A2 (en) 1999-12-09
WO1999062908A3 true WO1999062908A3 (en) 2000-03-30

Family

ID=22223903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/012419 WO1999062908A2 (en) 1998-06-04 1999-06-03 Cell adhesion-inhibiting antinflammatory compounds

Country Status (15)

Country Link
EP (1) EP1090009A2 (en)
JP (1) JP2002517396A (en)
KR (1) KR20010052570A (en)
CN (1) CN1332743A (en)
AU (1) AU4231299A (en)
BG (1) BG105109A (en)
BR (1) BR9910864A (en)
CA (1) CA2333770A1 (en)
HU (1) HUP0102366A2 (en)
IL (1) IL139811A0 (en)
NO (1) NO20006157L (en)
PL (1) PL345906A1 (en)
SK (1) SK18542000A3 (en)
TR (1) TR200100189T2 (en)
WO (1) WO1999062908A2 (en)

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US8691849B2 (en) 2008-09-02 2014-04-08 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
US8841323B2 (en) 2006-03-15 2014-09-23 Janssen Pharmaceuticals, Inc. 1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2-receptors
US8906939B2 (en) 2007-03-07 2014-12-09 Janssen Pharmaceuticals, Inc. 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
US8933085B2 (en) 2010-11-19 2015-01-13 Incyte Corporation Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
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US9034884B2 (en) 2010-11-19 2015-05-19 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
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