WO1999012532A3 - Piperidine derivatives against malaria - Google Patents

Piperidine derivatives against malaria Download PDF

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Publication number
WO1999012532A3
WO1999012532A3 PCT/EP1998/005570 EP9805570W WO9912532A3 WO 1999012532 A3 WO1999012532 A3 WO 1999012532A3 EP 9805570 W EP9805570 W EP 9805570W WO 9912532 A3 WO9912532 A3 WO 9912532A3
Authority
WO
WIPO (PCT)
Prior art keywords
piperidine derivatives
against malaria
derivatives against
patient
chloroquine
Prior art date
Application number
PCT/EP1998/005570
Other languages
French (fr)
Other versions
WO1999012532A2 (en
Inventor
Daniel Bur
Walter Fischli
Hugues Matile
Robert George Ridley
Wolfgang Wostl
Original Assignee
Hoffmann La Roche
Daniel Bur
Walter Fischli
Hugues Matile
Robert George Ridley
Wolfgang Wostl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Daniel Bur, Walter Fischli, Hugues Matile, Robert George Ridley, Wolfgang Wostl filed Critical Hoffmann La Roche
Priority to AU97409/98A priority Critical patent/AU9740998A/en
Publication of WO1999012532A2 publication Critical patent/WO1999012532A2/en
Publication of WO1999012532A3 publication Critical patent/WO1999012532A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention concerns the use of compounds of formula (I) and of pharmaceutically acceptable salts thereof, wherein R?1, R2, R3, R4¿ and Q are as hereinbefore defined, against chloroquine-sensitive and chloroquine-resistant pathogens and in the production of corresponding medicaments, furthermore corresponding medicaments and a method of treating malaria in a patient in need of such treatment which comprises administering to said patient an effective amount of a corresponding compound or medicament.
PCT/EP1998/005570 1997-09-08 1998-09-02 Piperidine derivatives against malaria WO1999012532A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU97409/98A AU9740998A (en) 1997-09-08 1998-09-02 Piperidine derivatives against malaria

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97115510.6 1997-09-08
EP97115510 1997-09-08

Publications (2)

Publication Number Publication Date
WO1999012532A2 WO1999012532A2 (en) 1999-03-18
WO1999012532A3 true WO1999012532A3 (en) 1999-07-29

Family

ID=8227323

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/005570 WO1999012532A2 (en) 1997-09-08 1998-09-02 Piperidine derivatives against malaria

Country Status (2)

Country Link
AU (1) AU9740998A (en)
WO (1) WO1999012532A2 (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691849B2 (en) 2008-09-02 2014-04-08 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
US8691813B2 (en) 2008-11-28 2014-04-08 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
US8841323B2 (en) 2006-03-15 2014-09-23 Janssen Pharmaceuticals, Inc. 1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2-receptors
US8906939B2 (en) 2007-03-07 2014-12-09 Janssen Pharmaceuticals, Inc. 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
US8937060B2 (en) 2009-05-12 2015-01-20 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo [4,3-A] pyridine derivatives and their use for the treatment of prevention of neurological and psychiatric disorders
US8946205B2 (en) 2009-05-12 2015-02-03 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
US9012448B2 (en) 2010-11-08 2015-04-21 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
US9085577B2 (en) 2009-05-12 2015-07-21 Janssen Pharmaceuticals, Inc. 7-aryl-1,2,4-triazolo[4,3-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
US9114138B2 (en) 2007-09-14 2015-08-25 Janssen Pharmaceuticals, Inc. 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′] bipyridinyl-2′-ones
US9271967B2 (en) 2010-11-08 2016-03-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376672B1 (en) * 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors
KR20030029978A (en) * 2000-09-25 2003-04-16 액테리온 파마슈티칼 리미티드 Substitued amino-aza-cycloalkanes useful aganist malaria
WO2003043987A2 (en) * 2001-11-19 2003-05-30 Elan Pharmaceuticals, Inc. (4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and related compounds as beta-secretase inhibitors for the treatment of alzheimer's disease
WO2004105762A1 (en) * 2003-05-30 2004-12-09 Actelion Pharmaceuticals Ltd Medical use of diazabicyclononene derivatives as inhibitors of parasite aspartic proteases
EP1707202A1 (en) * 2005-03-31 2006-10-04 Speedel Experimenta AG Organic compounds
EP1707206A1 (en) * 2005-03-31 2006-10-04 Speedel Experimenta AG Piperazine derivates for the inhibition of beta-secretase, cathepsin D, plasmepsin ll and HIV protease and for the treatment of malaria, Alzeheimer and AIDS
EP1987834A3 (en) * 2007-02-13 2008-11-19 Speedel Experimenta AG Substituted piperidines as therapeutic compounds
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
EP2301627A1 (en) * 2009-09-22 2011-03-30 University of Graz Novel antimalarial 3-azabicyclo[3.2.2]nonane derivatives
JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3367B1 (en) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
KR102502485B1 (en) 2014-01-21 2023-02-21 얀센 파마슈티카 엔.브이. Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
UA121965C2 (en) 2014-01-21 2020-08-25 Янссен Фармацевтика Нв Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2458146A1 (en) * 1973-12-07 1975-06-12 Hoffmann La Roche CHINOLINE DERIVATIVES
US3914235A (en) * 1968-07-02 1975-10-21 Hoffmann La Roche Processes and intermediates for quinine, quinidine, isomers and derivatives thereof
WO1997009311A1 (en) * 1995-09-07 1997-03-13 F. Hoffmann-La Roche Ag New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914235A (en) * 1968-07-02 1975-10-21 Hoffmann La Roche Processes and intermediates for quinine, quinidine, isomers and derivatives thereof
DE2458146A1 (en) * 1973-12-07 1975-06-12 Hoffmann La Roche CHINOLINE DERIVATIVES
WO1997009311A1 (en) * 1995-09-07 1997-03-13 F. Hoffmann-La Roche Ag New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARLIN, GORDON B. ET AL: "Potential antimalarials. XVI. 4'-Chloro-3-[7''-chloro(and trifluoromethyl)quinolin-4''-yl]amino-5-[(substituted amino)methyl]biphenyl-4-ols and 4'-bromo(and 3'-trifluoromethyl)-3- [(substituted amino)methyl]-5-(7''-trifluoromethylquinolin-4''- yl)aminobiphenyl-2-ols", AUST. J. CHEM. (1992), 45(11), 1845-55 CODEN: AJCHAS;ISSN: 0004-9425, XP002101247 *
MAAG, HANS ET AL: "5-(N-Arylnortropan-3-yl)- and 5-(N-arylpiperidin-4-yl)-2,4- diaminopyrimidines. Novel inhibitors of dihydrofolate reductase", HELV. CHIM. ACTA (1986), 69(4), 887-97 CODEN: HCACAV;ISSN: 0018-019X, 1986, XP002101246 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9266834B2 (en) 2006-03-15 2016-02-23 Janssen Pharmaceuticals, Inc. 1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2-receptors
US8841323B2 (en) 2006-03-15 2014-09-23 Janssen Pharmaceuticals, Inc. 1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2-receptors
US8906939B2 (en) 2007-03-07 2014-12-09 Janssen Pharmaceuticals, Inc. 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
US9114138B2 (en) 2007-09-14 2015-08-25 Janssen Pharmaceuticals, Inc. 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′] bipyridinyl-2′-ones
US9132122B2 (en) 2007-09-14 2015-09-15 Janssen Pharmaceuticals, Inc. 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones
US8691849B2 (en) 2008-09-02 2014-04-08 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
US8691813B2 (en) 2008-11-28 2014-04-08 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
US8937060B2 (en) 2009-05-12 2015-01-20 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo [4,3-A] pyridine derivatives and their use for the treatment of prevention of neurological and psychiatric disorders
US8946205B2 (en) 2009-05-12 2015-02-03 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
US9085577B2 (en) 2009-05-12 2015-07-21 Janssen Pharmaceuticals, Inc. 7-aryl-1,2,4-triazolo[4,3-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
US9226930B2 (en) 2009-05-12 2016-01-05 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment of prevention of neurological and psychiatric disorders
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
US9012448B2 (en) 2010-11-08 2015-04-21 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
US9271967B2 (en) 2010-11-08 2016-03-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors

Also Published As

Publication number Publication date
AU9740998A (en) 1999-03-29
WO1999012532A2 (en) 1999-03-18

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