WO1998048868A1 - Ultrasonic blood volume measurement soft-shell venous reservoir - Google Patents

Ultrasonic blood volume measurement soft-shell venous reservoir Download PDF

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Publication number
WO1998048868A1
WO1998048868A1 PCT/US1998/005727 US9805727W WO9848868A1 WO 1998048868 A1 WO1998048868 A1 WO 1998048868A1 US 9805727 W US9805727 W US 9805727W WO 9848868 A1 WO9848868 A1 WO 9848868A1
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WO
WIPO (PCT)
Prior art keywords
reservoir
volume
indication
transducer
blood
Prior art date
Application number
PCT/US1998/005727
Other languages
French (fr)
Inventor
Michael R. Van Driel
Darren S. Gray
Victor C. H. Lam
Amy P. Noss
Jill E. Uyeno
Yu-Tung Wong
Original Assignee
Medtronic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08840687 external-priority patent/US5756940C1/en
Application filed by Medtronic, Inc. filed Critical Medtronic, Inc.
Priority to EP98913066A priority Critical patent/EP1011751A1/en
Priority to PCT/US1998/005727 priority patent/WO1998048868A1/en
Priority to JP54698098A priority patent/JP4160128B2/en
Publication of WO1998048868A1 publication Critical patent/WO1998048868A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01G—WEIGHING
    • G01G17/00—Apparatus for or methods of weighing material of special form or property
    • G01G17/04—Apparatus for or methods of weighing material of special form or property for weighing fluids, e.g. gases, pastes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3607—Regulation parameters
    • A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3624—Level detectors; Level control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633—Blood component filters, e.g. leukocyte filters
    • A61M1/3635—Constructional details
    • A61M1/3636—Constructional details having a flexible housing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
    • G01F23/20—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measurement of weight, e.g. to determine the level of stored liquefied gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
    • A61M2205/3389—Continuous level detection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
    • A61M2205/3393—Masses, volumes, levels of fluids in reservoirs, flow rates by weighing the reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/08—Supports for equipment
    • A61M2209/082—Mounting brackets, arm supports for equipment

Definitions

  • This invention relates to the measurement of the blood volume in a soft-shell venous reservoir of a heart-lung machine, and more particularly to a method and apparatus using ultrasonic measurement of the width variations of the reservoir to track blood volume variations.
  • Heart-lung machines conventionally include a venous reservoir which receives the patient's blood at a variable rate during open-heart surgery and releases it at a substantially steady rate to the oxygenation circuit from which it is returned to the patient.
  • Rigid hard-shell reservoirs lend themselves well to this purpose because accurate graduations can readily be inscribed on their surface. However, because the volume of the hard-shell reservoir itself is constant, it will discharge potentially lethal air into the blood circuit of the heart-lung machine if it is allowed to become empty.
  • Collapsible soft-shell reservoirs i.e. plastic bags
  • soft-shell reservoirs because they are always exactly filled with blood, cannot provide a visible volume indication by way of graduations.
  • Fig. 1 is a side elevation of the reservoir bag and transducer portion of a preferred embodiment of the invention
  • Fig. 2 is a section along line 2-2 of Fig. 1;
  • Fig. 3 is a section along line 3-3 of Fig. 1;
  • Fig. 4 is a block diagram showing the determination of blood volume from the ultrasonic scan;
  • Fig. 5 is a schematic elevation of an alternative embodiment of the invention. Description of the preferred embodiment
  • Figs. 1-3 show the structural portion 10 of the present invention.
  • a plastic sheet whose central section forms an expandable soft-shell venous reservoir bag 12 is firmly attached at 13 (Fig. 2) against the backplate 14 of a reservoir holder which may conveniently be mounted on an IN stand (not shown) or the like.
  • Inlet connectors 16 and an outlet connector 18 extend into the bag 12 to convey blood into and out of the bag 12.
  • a transducer unit 20 is so mounted with respect to the backplate 14 as to be biased toward it, and consequently toward the bag 12, as indicated by the arrow 22. This may be accomplished by mounting the transducer unit 20 on an arm 21 for pivotal movement about a spring-loaded hinge 23.
  • the transducer unit 20 has attached to its active face at 25 (Fig.
  • a flexible container 24 of acoustically conductive gel 26 which is in contact with both the transducers of transducer unit 20 and the surface of the bag 12.
  • the gel material 26 is sufficiently fluid to allow the flexible container 24 to follow the deformation of, and remain in contact with, the surface of bag 12 as blood is introduced and discharged through the connectors 16, 18 at varying rates.
  • the venous reservoir bag 12 does not expand by more than about 1.5 cm between its empty and full conditions, so that little deformation of the gel layer occurs.
  • the bag 12 is formed of a material such as polyvinyl chloride, which is flexible yet provides a strong ultrasonic echo.
  • the transducer unit 20 may take various forms. In the preferred embodiment, however, the unit 20 consists of a two-dimensional array of transducers disposed to face strategic points on the surface of the bag 12. In this respect, it should be noted that the bag 12, when filled with blood, will expand in a rather uniform geometric shape, so that the shape of the bag can be accurately interpolated from relatively few reference points (and hence few transducers). The number of reference points necessary for an accurate shape determination will vary depending upon the structure and shape of a particular model of bag 12.
  • Fig. 4 shows, in schematic form, the derivation of the volume indication in the apparatus of this invention.
  • the transducer array 20 is continually sequentially driven and read by a scanner/receiver 28.
  • a boundary/thickness detector 30 locates the peaks in the received echo that identify the walls of the bag 12 and computes the distance between the walls from the time difference between the echo peaks. This information is then applied to a differentiator/integrator 32 which determines the cross-sectional area of the bag 12 between array elements in the manner described below.
  • a multiplier/adder 34 uses the output of differentiator/integrator 32 at various scan points to compute the volume of bag 12 in real time, and the result can be displayed on a digital volume display 36.
  • the surface of the bag 12 assumes a predictable curvature at representative points on the surface, and because that curvature is a function of the distance between the walls of the bag 12 at those points, it is possible to accurately calculate the variation of dz/dx (where z is the distance between the walls of the bag 12 and x is the horizontal position) between two rather widely spaced horizontally adjacent points. By integrating this function between the two points, the horizontal cross-sectional area of the bag 12 between the two points can be computed. By performing the same calculation in the vertical direction and multiplying the results, increments of volume can be accurately calculated and added to provide the total volume in the bag 12.
  • the transducer unit 20 is replaced by a traveling transducer or horizontal transducer array 40 which may be mounted on a telescoping arm 42.
  • a spring 44 may be used to bias the transducer 40 against the bag 12
  • a motor 46 may be used to move the arm 42 up and down on a pole 48.
  • the signal obtained by a pass of the transducers along the center of the bag 12 represents the vertical section of the bag 12 having the maximum expansion. Knowing the shape of the bag, this representation can be translated into a volume indication.
  • the exemplary ultrasonic measurement of blood volume in soft-shell venous reservoirs described herein and shown in the drawings represents only presently preferred embodiments of the invention. Indeed, various modifications and additions may be made to such embodiment without departing from the spirit and scope of the invention.
  • the ultrasound emitter or emitters may be in the unit 20 while the receivers are in the backplate 14.
  • other modifications and additions may be obvious to those skilled in the art and may be implemented to adapt the present invention for use in a variety of different applications.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • External Artificial Organs (AREA)

Abstract

Blood volume in a soft-shell venous reservoir is measured for real-time display by ultrasonically measuring the distance between the walls of the reservoir bag at representative points and determining the volume of the bag by an interpolation based on the known shape of the reservoir bag as it expands and contracts.

Description

ULTRASONIC BLOOD VOLUME MEASUREMENT SOFT-SHELL VENOUS RESERVOIR
Field of the invention This invention relates to the measurement of the blood volume in a soft-shell venous reservoir of a heart-lung machine, and more particularly to a method and apparatus using ultrasonic measurement of the width variations of the reservoir to track blood volume variations. Background of the invention Heart-lung machines conventionally include a venous reservoir which receives the patient's blood at a variable rate during open-heart surgery and releases it at a substantially steady rate to the oxygenation circuit from which it is returned to the patient. In the operation of the heart-lung machine, it is important for the perfusionist to be continuously advised of the exact volume of blood in the reservoir, as this information is needed to maintain the correct diluted blood volume in the patient and to calculate the proper doses of infused drugs.
Rigid hard-shell reservoirs lend themselves well to this purpose because accurate graduations can readily be inscribed on their surface. However, because the volume of the hard-shell reservoir itself is constant, it will discharge potentially lethal air into the blood circuit of the heart-lung machine if it is allowed to become empty.
Collapsible soft-shell reservoirs (i.e. plastic bags) have the advantage of increasing and reducing their volume in accordance with the amount of blood they contain, and they consequently need no airspace that could produce emboli. On the other hand, soft-shell reservoirs, because they are always exactly filled with blood, cannot provide a visible volume indication by way of graduations.
In the past, perfusionists have estimated the blood volume in soft-shell reservoirs by the appearance of the reservoir bag, but this requires experience and is not sufficiently accurate for modern requirements. To remedy this deficiency, it has previously been proposed to position the reservoir bag between two parallel plates which are biased against the bag, and whose distance from each other as the bag expands and contracts is indicated by a tape measure. That system, however, is not very accurate and is awkward to observe. Ultrasonic volume measurement has been proposed in the form of an ultrasound image scan of a patient's abdomen to calculate the volume of urine in the patient's bladder, but this procedure can only produce approximate results and would not be suitable for venous reservoir evaluation.
There consequently remains a need for a system which can provide a substantially exact measurement of the fluid volume in a soft-shell venous reservoir on a continuing basis. Summary of the invention The present invention fills the above need by using ultrasound to locate the walls of the reservoir bag and to provide an indication of the distance between them at representative points on the surface of the bag. The readings at these points can be interpolated and integrated by a microprocessor to provide a volume indication that can be digitally displayed on a monitor. Brief description of the drawings
Fig. 1 is a side elevation of the reservoir bag and transducer portion of a preferred embodiment of the invention;
Fig. 2 is a section along line 2-2 of Fig. 1; and
Fig. 3 is a section along line 3-3 of Fig. 1; Fig. 4 is a block diagram showing the determination of blood volume from the ultrasonic scan; and
Fig. 5 is a schematic elevation of an alternative embodiment of the invention. Description of the preferred embodiment
Figs. 1-3 show the structural portion 10 of the present invention. A plastic sheet whose central section forms an expandable soft-shell venous reservoir bag 12 is firmly attached at 13 (Fig. 2) against the backplate 14 of a reservoir holder which may conveniently be mounted on an IN stand (not shown) or the like. Inlet connectors 16 and an outlet connector 18 extend into the bag 12 to convey blood into and out of the bag 12. A transducer unit 20 is so mounted with respect to the backplate 14 as to be biased toward it, and consequently toward the bag 12, as indicated by the arrow 22. This may be accomplished by mounting the transducer unit 20 on an arm 21 for pivotal movement about a spring-loaded hinge 23. The transducer unit 20 has attached to its active face at 25 (Fig. 3) a flexible container 24 of acoustically conductive gel 26 which is in contact with both the transducers of transducer unit 20 and the surface of the bag 12. The gel material 26 is sufficiently fluid to allow the flexible container 24 to follow the deformation of, and remain in contact with, the surface of bag 12 as blood is introduced and discharged through the connectors 16, 18 at varying rates. The venous reservoir bag 12 does not expand by more than about 1.5 cm between its empty and full conditions, so that little deformation of the gel layer occurs. Preferably, the bag 12 is formed of a material such as polyvinyl chloride, which is flexible yet provides a strong ultrasonic echo.
The transducer unit 20 may take various forms. In the preferred embodiment, however, the unit 20 consists of a two-dimensional array of transducers disposed to face strategic points on the surface of the bag 12. In this respect, it should be noted that the bag 12, when filled with blood, will expand in a rather uniform geometric shape, so that the shape of the bag can be accurately interpolated from relatively few reference points (and hence few transducers). The number of reference points necessary for an accurate shape determination will vary depending upon the structure and shape of a particular model of bag 12.
Fig. 4 shows, in schematic form, the derivation of the volume indication in the apparatus of this invention. The transducer array 20 is continually sequentially driven and read by a scanner/receiver 28. A boundary/thickness detector 30 locates the peaks in the received echo that identify the walls of the bag 12 and computes the distance between the walls from the time difference between the echo peaks. This information is then applied to a differentiator/integrator 32 which determines the cross-sectional area of the bag 12 between array elements in the manner described below. A multiplier/adder 34 uses the output of differentiator/integrator 32 at various scan points to compute the volume of bag 12 in real time, and the result can be displayed on a digital volume display 36.
Because the surface of the bag 12, as it fills, assumes a predictable curvature at representative points on the surface, and because that curvature is a function of the distance between the walls of the bag 12 at those points, it is possible to accurately calculate the variation of dz/dx (where z is the distance between the walls of the bag 12 and x is the horizontal position) between two rather widely spaced horizontally adjacent points. By integrating this function between the two points, the horizontal cross-sectional area of the bag 12 between the two points can be computed. By performing the same calculation in the vertical direction and multiplying the results, increments of volume can be accurately calculated and added to provide the total volume in the bag 12.
In another preferred embodiment of the invention shown in Fig. 5, the transducer unit 20 is replaced by a traveling transducer or horizontal transducer array 40 which may be mounted on a telescoping arm 42. A spring 44 may be used to bias the transducer 40 against the bag 12, and a motor 46 may be used to move the arm 42 up and down on a pole 48. The signal obtained by a pass of the transducers along the center of the bag 12 represents the vertical section of the bag 12 having the maximum expansion. Knowing the shape of the bag, this representation can be translated into a volume indication.
It is understood that the exemplary ultrasonic measurement of blood volume in soft-shell venous reservoirs described herein and shown in the drawings represents only presently preferred embodiments of the invention. Indeed, various modifications and additions may be made to such embodiment without departing from the spirit and scope of the invention. For example, in the embodiment of Fig. 1, the ultrasound emitter or emitters may be in the unit 20 while the receivers are in the backplate 14. Thus, other modifications and additions may be obvious to those skilled in the art and may be implemented to adapt the present invention for use in a variety of different applications.

Claims

1. A method of measuring the blood volume in an expandable soft-shell venous reservoir, comprising the steps of: a) ultrasonically producing an indication of the thickness of said reservoir at predetermined discrete points on said reservoir; b) interpolating said indication between said points in accordance with the predetermined curvature of said reservoir as it expands; and c) translating said interpolated indication into a displayable volume measurement.
2. The method of Claim 1 , in which said indication-producing step includes the steps of: i) applying ultrasonic transducing apparatus in sout-transmitting relationship against the expandable surface of said reservoir; ii) obtaining ultrasonic echoes from the walls of said reservoir; and iii) using said echoes to monitor the thickness of said reservoir at said discrete points.
3. The method of Claim 1 , in which said ultrasonic ransducing apparatus is a transducer array substantially parallel to the expandable surface of said reservoir.
4. The method of Claim 1 , in which said transducing apparatus is a movable transducer arranged to travel along the expandable surface of said reservoir.
5. A system for measuring blood volume stored in a blood circuit, comprising: a) a soft-shell reservoir for storing blood in said circuit, the walls of said reservoir being ultrasound-reflective and said reservoir being expandable and collapsible so as to always have a volume equal to the volume of blood stored therein; b) a backplate for mounting said reservoir; c) ultrasonic transducing apparatus arranged to be biased in sound transmitting relationship against the surface of said reservoir opposite said backplace, and to continually provide an indication of the thickness of said reservoir at discrete points on its surface; and d) computing apparatus arranged to compute from said indication a displayable real-time measurement of the volume of said reservoir.
6. The system of Claim 5, in which a flexible container of a sound-transmitting gel is interposed between said transducing apparatus and said reservoir surface so as to maintain said transducing apparatus in sound-transmitting contact with said surface as said reservoir expands and contracts.
7. The system of Claim 4, in which said transducer apparatus is a transducer mounted for movement along said surface of saaid reservoir.
8. The system of Claim 5, in which said transducer apparatus is a transducer mounted for movement along said surface of said reservoir.
PCT/US1998/005727 1997-04-29 1998-03-24 Ultrasonic blood volume measurement soft-shell venous reservoir WO1998048868A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP98913066A EP1011751A1 (en) 1997-04-29 1998-03-24 Ultrasonic blood volume measurement soft-shell venous reservoir
PCT/US1998/005727 WO1998048868A1 (en) 1997-04-29 1998-03-24 Ultrasonic blood volume measurement soft-shell venous reservoir
JP54698098A JP4160128B2 (en) 1997-04-29 1998-03-24 Ultrasonic measurement of blood volume in soft shell venous blood reservoir

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08840687 US5756940C1 (en) 1997-04-29 1997-04-29 Weight measurement of blood volume soft-shell venous reservoirs
US08/840,687 1997-04-29
PCT/US1998/005727 WO1998048868A1 (en) 1997-04-29 1998-03-24 Ultrasonic blood volume measurement soft-shell venous reservoir

Publications (1)

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WO1998048868A1 true WO1998048868A1 (en) 1998-11-05

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2380611A1 (en) * 2010-04-20 2011-10-26 Sorin Group Italia S.r.l. Blood reservoir with level sensor
US8500673B2 (en) 2010-04-20 2013-08-06 Sorin Group Italia S.R.L. Blood reservoir with level sensor
US8506513B2 (en) 2010-04-20 2013-08-13 Sorin Group Italia S.R.L. Blood reservoir with ultrasonic volume sensor
US9011769B2 (en) 2011-07-12 2015-04-21 Sorin Group Italia S.R.L. Dual chamber blood reservoir
US9452250B2 (en) 2009-06-25 2016-09-27 Sorin Group Deutschland Gmbh Device for pumping blood in an extracorporeal circuit
US10458833B2 (en) 2014-05-16 2019-10-29 Sorin Group Italia S.R.L. Blood reservoir with fluid volume measurement based on pressure sensor
US11229729B2 (en) 2009-05-29 2022-01-25 Livanova Deutschland Gmbh Device for establishing the venous inflow to a blood reservoir of an extracorporeal blood circulation system

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021311A2 (en) * 1993-03-24 1994-09-29 Haemonetics Corporation Blood reservoir volume sensing system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021311A2 (en) * 1993-03-24 1994-09-29 Haemonetics Corporation Blood reservoir volume sensing system

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11229729B2 (en) 2009-05-29 2022-01-25 Livanova Deutschland Gmbh Device for establishing the venous inflow to a blood reservoir of an extracorporeal blood circulation system
US11844892B2 (en) 2009-05-29 2023-12-19 Livanova Deutschland Gmbh Device for establishing the venous inflow to a blood reservoir of an extracorporeal blood circulation system
US9452250B2 (en) 2009-06-25 2016-09-27 Sorin Group Deutschland Gmbh Device for pumping blood in an extracorporeal circuit
EP2380611A1 (en) * 2010-04-20 2011-10-26 Sorin Group Italia S.r.l. Blood reservoir with level sensor
EP2380613A3 (en) * 2010-04-20 2011-12-07 Sorin Group Italia S.r.l. Blood reservoir with ultrasonic volume sensor
EP2465556A1 (en) * 2010-04-20 2012-06-20 Sorin Group Italia S.r.l. Blood reservoir with ultrasonic volume sensor
US8500673B2 (en) 2010-04-20 2013-08-06 Sorin Group Italia S.R.L. Blood reservoir with level sensor
US8506513B2 (en) 2010-04-20 2013-08-13 Sorin Group Italia S.R.L. Blood reservoir with ultrasonic volume sensor
US9011769B2 (en) 2011-07-12 2015-04-21 Sorin Group Italia S.R.L. Dual chamber blood reservoir
US10213541B2 (en) 2011-07-12 2019-02-26 Sorin Group Italia S.R.L. Dual chamber blood reservoir
US11389580B2 (en) 2011-07-12 2022-07-19 Sorin Group Italia S.R.L. Dual chamber blood reservoir
US10458833B2 (en) 2014-05-16 2019-10-29 Sorin Group Italia S.R.L. Blood reservoir with fluid volume measurement based on pressure sensor

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Publication number Publication date
JP4160128B2 (en) 2008-10-01
EP1011751A1 (en) 2000-06-28
JP2001523339A (en) 2001-11-20

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