WO1997041901B1 - Pentosanpolysulfate coating for medical devices - Google Patents
Pentosanpolysulfate coating for medical devicesInfo
- Publication number
- WO1997041901B1 WO1997041901B1 PCT/US1997/007178 US9707178W WO9741901B1 WO 1997041901 B1 WO1997041901 B1 WO 1997041901B1 US 9707178 W US9707178 W US 9707178W WO 9741901 B1 WO9741901 B1 WO 9741901B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- medical device
- pentosanpolysulfate
- layer
- bladder
- attachment area
- Prior art date
Links
- FCCNSUIJIOOXEZ-SJYYZXOBSA-N Pentosan Polysulfate Chemical compound OS(=O)(=O)O[C@@H]1[C@@H](OS(O)(=O)=O)[C@H](O)CO[C@H]1O[C@H]1[C@H](OS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@H](O)OC1 FCCNSUIJIOOXEZ-SJYYZXOBSA-N 0.000 title claims abstract 29
- 229940043138 Pentosan Polysulfate Drugs 0.000 title claims abstract 29
- 239000011248 coating agent Substances 0.000 title claims abstract 4
- 238000000576 coating method Methods 0.000 title claims abstract 4
- 239000000463 material Substances 0.000 claims abstract 15
- 210000001635 Urinary Tract Anatomy 0.000 claims abstract 7
- 210000001519 tissues Anatomy 0.000 claims abstract 2
- 210000003932 Urinary Bladder Anatomy 0.000 claims 13
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 210000002700 Urine Anatomy 0.000 claims 4
- 210000002381 Plasma Anatomy 0.000 claims 2
- 238000007598 dipping method Methods 0.000 claims 2
- 238000001125 extrusion Methods 0.000 claims 2
- 238000002513 implantation Methods 0.000 claims 2
- 238000001802 infusion Methods 0.000 claims 2
- 238000000465 moulding Methods 0.000 claims 2
- -1 polyethylene Polymers 0.000 claims 2
- 210000001124 Body Fluids Anatomy 0.000 claims 1
- 210000003734 Kidney Anatomy 0.000 claims 1
- 239000004698 Polyethylene (PE) Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 210000000626 Ureter Anatomy 0.000 claims 1
- 239000012237 artificial material Substances 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 239000006227 byproduct Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 230000002269 spontaneous Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000011780 sodium chloride Substances 0.000 abstract 2
- 208000003228 Foreign Body Diseases 0.000 abstract 1
- 208000005422 Foreign-Body Reaction Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000002238 attenuated Effects 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 231100000486 side effect Toxicity 0.000 abstract 1
Abstract
A pentosanpolysulfate coating on medical devices reduces or eliminates side effects associated with the introduction of foreign bodies into the urinary tract of a patient. The pentosanpolysulfate coating attenuates the attachment of salts, minerals, proteins, salt, and other undesirable materials onto the medical device used in the urinary tract. Inflammatory or foreign body reaction to these pentosanpolysulfate coated medical devices are also attenuated, and growth of healthy normal tissue in the vicinity of the coated medical device of the present invention is allowed.
Claims
1. A medical device for use in the urinary tract, said medical device comprising a surface and a layer of pentosanpolysulfate bonded on said surface.
2. The medical device of Claim 1, further comprising a polymeric material produced by one of an extrusion process, a molding process, and a dipping process, wherein the medical device is selected from the group consisting of an intravesical infusion device, a ureteral stent and an artificial bladder.
3. The medical device of Claim 1, wherein the layer of pentosanpolysulfate remains on the surface when the medical device is implanted into a patient.
4. The medical device of Claim 1 , wherein the layer of pentosanpolysulfate is permanently bonded to the surface.
5. The medical device of Claim 1 , wherein the layer of pentosanpolysulfate is covalently bonded to the surface.
6. The medical device of Claim 1 , wherein the layer of pentosanpolysulfate is ionically bonded to the surface.
7. The medical device of Claim 1 , wherein the entire surface of said medical device is covered by said pentosanpolysulfate.
8. The medical device of Claim 1, wherein said pentosanpolysulfate is present in an amount effective to attenuate attachment of materials present in the urinary tract to said surface.
9. The medical device of Claim 1, wherein said surface is pretreated so as to create an attachment area thereon for said pentosanpolysulfate.
10. The medical device of Claim 9, wherein said attachment area is created by a method selected from the group consisting of exposing said medical device to a solution containing an agent with a low pH, exposing the medical device to a solution of photoreactive agents and a high electromagnetic energy source and exposing the surface of the medical device to high energy plasma or high energy radiation.
11. The medical device of Claim 9, wherein said attachment area comprises a secondary molecular surface attached thereto.
12. A method for coating a surface of a medical device for use in the urinary tract with a layer of pentosanpolysulfate, comprising the following steps: providing an attachment area on said surface; and exposing the surface to a solution comprising pentosanpolysulfate, wherein the layer of pentosanpolysulfate becomes bonded to said surface.
13. The method of Claim 12, further comprising the step of removing at least one byproduct or residual from said surface, to thereby leave only the attachment area coated with the layer of pentosanpolysulfate.
14. The method of Claim 12, wherein the step of providing an attachment area comprises the steps of: attaching a secondary molecular surface to the attachment area; and creating the attachment area on the secondary molecular surface, said attachment area being capable of binding pentosanpolysulfate.
15. The method of Claim 12, wherein the solution comprises both pentosanpolysulfate and at least one attaching agent.
16. The method of Claim 15, wherein said attaching agent comprises carrier molecules.
17. The method of Claim 16, wherein the step of creating an attachment area includes the step of exposing said surface to a solution containing an agent having a low pH.
18. The method of Claim 16, wherein the step of creating an attachment area includes the step of exposing said surface to a solution of photoreactive agents and an electromagnetic energy source.
19. The method of Claim 12, wherein the step of creating an attachment area includes the step of exposing said surface to a high energy plasma.
20. The method of Claim 12, wherein the step of creating an attachment area includes the step of exposing said surface to a high energy radiation.
21. The method of Claim 20, wherein the high energy radiation comprises at least one of gamma and corona discharge.
22. The method of Claim 12, wherein the medical device comprises a polymeric material and is produced by at least one of an extrusion process, a molding process and a dipping process.
23. The method of Claim 22, wherein the polymeric material comprises at least one of silicone, polyethylene, polypropylene, polyurethane and polyvinylchloride. 27
24. The method of Claim 22, wherein the layer of pentosanpolysulfate is incorporated into a matrix of the polymeric material during the production of the medical device.
25. The method of Claim 12, wherein the medical device is selected from the group consisting of an intravesical infusion device, a ureteral stent and an artificial bladder.
26. A medical device, comprising: a synthetic bladder patch for providing pressure relief to spontaneous contractions of a bladder and for enlarging the bladder to increase a volume of the bladder, the synthetic bladder patch comprising: an artificial material forming a surface of the synthetic bladder patch; and pentosanpolysulfate disposed over the surface of the synthetic bladder patch.
27. A medical device, comprising: a ureteral stent for substituting the function of the ureter as a conduit for the passage of urine from the kidneys to the bladder for extended periods of time, the ureteral stent comprising: a polymeric base material forming a tube with an inner surface and an outer surface; and a layer of pentosanpolysulfate disposed over portions of the polymeric base material which may be exposed to urine.
28. The medical device of Claim 27, wherein the layer of pentosanpolysulfate is permanently bonded to both the inner surface and the outer surface.
29. The medical device of Claim 27, wherein the layer of pentosanpolysulfate remains over both the inner surface and the outer surface thereof after implantation into a patient.
30. A medical device, comprising: an intravesical infuser for implantation into the bladder for extended periods of time, said intravesical infuser comprising: a polymeric base material; and a layer of pentosanpolysulfate disposed over portions of the polymeric base material which may be exposed to urine within the bladder. 28
31. The medical device of Claim 30, wherein the layer of pentosanpolysulfate is permanently bonded to the portions of the polymeric base material.
32. The medical device of Claim 30, wherein the layer of pentosanpolysulfate remains bonded to the portions of the polymeric base material when the portions are exposed to urine within the bladder for a period of time exceeding 30 days.
33. The medical device of Claim 30, further comprising infuser outlet valving capable of maintaining a relatively constant flow rate over a wide range of driving pressures.
34. A non-dissolvable suture for permanently attaching a device in the urinary tract of a patient, comprising: a base material; and a layer of pentosanpolysulfate over the base material, the layer of pentosanpolysulfate over the base material.
35. A medical device for use in the urinary tract, comprising: a contacting surface for contacting at least one of a body tissue and a body fluid; and a layer of pentosanpolysulfate bonded on said contacting surface.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP09539992A JP2000510720A (en) | 1996-05-03 | 1997-04-29 | Pentosan polysulfate coating for medical devices |
| EP97921445A EP0900092A1 (en) | 1996-05-03 | 1997-04-29 | Pentosanpolysulfate coating for medical devices |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64239196A | 1996-05-03 | 1996-05-03 | |
| US08/642,391 | 1996-05-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1997041901A1 WO1997041901A1 (en) | 1997-11-13 |
| WO1997041901B1 true WO1997041901B1 (en) | 1997-12-18 |
Family
ID=24576354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/007178 WO1997041901A1 (en) | 1996-05-03 | 1997-04-29 | Pentosanpolysulfate coating for medical devices |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US5935094A (en) |
| EP (1) | EP0900092A1 (en) |
| JP (1) | JP2000510720A (en) |
| WO (1) | WO1997041901A1 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6171298B1 (en) | 1996-05-03 | 2001-01-09 | Situs Corporation | Intravesical infuser |
| US5718717A (en) | 1996-08-19 | 1998-02-17 | Bonutti; Peter M. | Suture anchor |
| US6045551A (en) | 1998-02-06 | 2000-04-04 | Bonutti; Peter M. | Bone suture |
| US6368343B1 (en) | 2000-03-13 | 2002-04-09 | Peter M. Bonutti | Method of using ultrasonic vibration to secure body tissue |
| US6447516B1 (en) | 1999-08-09 | 2002-09-10 | Peter M. Bonutti | Method of securing tissue |
| US6635073B2 (en) | 2000-05-03 | 2003-10-21 | Peter M. Bonutti | Method of securing body tissue |
| US6311689B1 (en) * | 2000-03-10 | 2001-11-06 | Conticare Medical, Inc. | Female incontinence prevention device |
| US6719765B2 (en) | 2001-12-03 | 2004-04-13 | Bonutti 2003 Trust-A | Magnetic suturing system and method |
| US8506647B2 (en) | 2002-02-14 | 2013-08-13 | Boston Scientific Scimed, Inc. | System for maintaining body canal patency |
| US7488757B2 (en) | 2003-03-24 | 2009-02-10 | Becton, Dickinson And Company | Invisible antimicrobial glove and hand antiseptic |
| WO2005056094A1 (en) | 2003-11-20 | 2005-06-23 | Nmt Medical, Inc. | Air embolization prevention system |
| US20070172508A1 (en) * | 2006-01-26 | 2007-07-26 | Paul Zupkas | Transluminal drug delivery methods and devices |
| US20080208083A1 (en) * | 2006-04-28 | 2008-08-28 | Bryant Lin | System and method to counter material deposition on devices in the urinary tract |
| JP5419682B2 (en) * | 2007-03-23 | 2014-02-19 | Ｊｓｒ株式会社 | Coating composition and method of use thereof |
| CN106964053A (en) * | 2017-04-11 | 2017-07-21 | 张家港市沙工医疗器械科技发展有限公司 | A kind of J-type conduit of high-elastic disintegratable |
| CN113663142A (en) * | 2021-09-03 | 2021-11-19 | 中国科学院长春应用化学研究所 | Multifunctional coating suitable for urinary medical instruments, and preparation method and application thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3617344A (en) * | 1966-08-05 | 1971-11-02 | Us Health Education & Welfare | Nonthrombogenic plastic surfaces and preparation thereof |
| US4240163A (en) * | 1979-01-31 | 1980-12-23 | Galin Miles A | Medicament coated intraocular lens |
| US4326532A (en) * | 1980-10-06 | 1982-04-27 | Minnesota Mining And Manufacturing Company | Antithrombogenic articles |
| US5180715A (en) * | 1980-11-17 | 1993-01-19 | The Regents Of The University Of California | Irrigation of internal bladder surfaces in mammals with sodium pentosanpolysulfate |
| US4529614A (en) * | 1981-12-02 | 1985-07-16 | Becton, Dickinson And Company | One step anticoagulant coating |
| CA1215676A (en) * | 1983-04-27 | 1986-12-23 | Terry S. Dunn | Heparinization of plasma treated substrates |
| US4613517A (en) * | 1983-04-27 | 1986-09-23 | Becton, Dickinson And Company | Heparinization of plasma treated surfaces |
| US4678660A (en) * | 1984-12-07 | 1987-07-07 | Deseret Medical, Inc. | Thermoplastic polyurethane anticoagulant alloy coating |
| US4720512A (en) * | 1986-03-24 | 1988-01-19 | Becton, Dickinson And Company | Polymeric articles having enhanced antithrombogenic activity |
| US4895566A (en) * | 1986-07-25 | 1990-01-23 | C. R. Bard, Inc. | Coating medical devices with cationic antibiotics |
| US5047020A (en) * | 1987-09-14 | 1991-09-10 | Baxter International Inc. | Ionic heparin coating |
| US5077052A (en) * | 1988-11-30 | 1991-12-31 | Rhone-Poulenc Sante | Chitosan derivatives useful in compositions for coating feedstuff additives intended for ruminants |
| US5292362A (en) * | 1990-07-27 | 1994-03-08 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
| US5605938A (en) * | 1991-05-31 | 1997-02-25 | Gliatech, Inc. | Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate |
| UA35578C2 (en) * | 1991-08-16 | 2001-04-16 | Майлс Е. Гелін | Intraocular implant for anterior chamber of eye, method for manufacture, and method for treating myopia |
| ES2106318T3 (en) * | 1991-12-06 | 1997-11-01 | North Shore Univ Hospital | METHOD TO REDUCE INFECTIONS RELATED TO MEDICAL DEVICES. |
| US5436291A (en) * | 1992-07-09 | 1995-07-25 | University Of Michigan, The Board Of . . . | Calcification-resistant synthetic biomaterials |
| DE69330909T2 (en) * | 1992-11-12 | 2002-06-20 | Neville Alleyne | HEART PROTECTION DEVICE |
| US6695813B1 (en) * | 1999-12-30 | 2004-02-24 | Advanced Cardiovascular Systems, Inc. | Embolic protection devices |
-
1997
- 1997-04-29 JP JP09539992A patent/JP2000510720A/en active Pending
- 1997-04-29 EP EP97921445A patent/EP0900092A1/en not_active Withdrawn
- 1997-04-29 WO PCT/US1997/007178 patent/WO1997041901A1/en not_active Application Discontinuation
- 1997-10-03 US US08/942,972 patent/US5935094A/en not_active Expired - Fee Related
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