WO1996034633A1 - Dressing set - Google Patents
Dressing set Download PDFInfo
- Publication number
- WO1996034633A1 WO1996034633A1 PCT/SE1996/000567 SE9600567W WO9634633A1 WO 1996034633 A1 WO1996034633 A1 WO 1996034633A1 SE 9600567 W SE9600567 W SE 9600567W WO 9634633 A1 WO9634633 A1 WO 9634633A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reservoir
- dressing set
- dressing
- foil
- backing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
- A61M35/006—Portable hand-held applicators having means for dispensing or spreading integral media using sponges, foams, absorbent pads or swabs as spreading means
Abstract
A dressing set (1) comprising a non-occlusive backing (2), which backing (2) optionally has at least one adhesive side (4), a reservoir (3), which reservoir (3) in area is smaller than or at most equal to the backing (2) and which reservoir (3) comprises one or more layers and at least one pharmaceutically active compound, and optionally one or more peel strips, release papers (6) or similar arrangement protecting the reservoir (3) and/or the optional adhesive side (4) of said backing (2). A foil (5) having an area being larger than or at least equal to the area of the reservoir (3) is located between the reservoir (3) and the backing (2), which foil (5) consists of at least one hydrophilic or hydrophilized polymer. The foil (5) is in a dry, moisture-free state substantially occlusive, and after moisture absorption substantially non-occlusive.
Description
DRESSING SET
The present invention refers to a dressing set primarily intended as a wound dressing and for transdermal drug delivery, so called TDDS (Transdermal Drug Delivery Systems) and/or similar pharmaceutical and medical applications. The dressing set comprises a hydrofil barrier located between the drug reservoir and the backing of said set. The barrier is in a dry, moisture free, state occlusive and after moisture absorption non-occlusive.
A dressing set normally comprises an adhesive backing, a reservoir such as a compress, swab, matrix or similar having one or more layers and containing at least one pharmaceutically active compound, such as a drug or an antiseptic, and one or more peel strips, release papers or the like protecting the adhesive backing and/or the reservoir.
Dressing sets are used in a number of applications including wound dressings, antiseptic and chemotherapeutic dressings. Wound dressings include compresses or swabs containing one or more pharmaceutical compounds, which compresses are attached onto a patient by means of adhesive tapes or plasters. Application areas of TDDS include for instance treatment of angina pectoris, diabetes and motion sickness, and are used in smoking cessation therapy. The use of TDDS is rapidly growing and the drug containing reservoirs are gradually improved with pendant increased security and thus a more controlled drug delivery. The use and development of various TDDS are in detail described in "Transdermal Drug Delivery - volume 35 - Development Issues and Research Initiatives" edited by J. Hadgraft and R.H. Guy and issued by Marcel Dekker Inc., New York, USA.
A major problem during storage and use of dressing sets comprising a reservoir, such as a compress, a matrix or similar, containing for instance one or more drugs, is migration or other type of leakage of the active compound into or through the backing material. This implies a reduced storage time, an uncertain amount of active compound available for the actual treatment, unfavourable chemical and/or physical interactions between the active compound and the backing material and handling as well as health hazards due to drug impregnated or otherwise drug containing packages. The risk of incorrect or hazardous treatment as well as said health hazards, related to the handling of for instance drug containing packages, is obvious. Migration or other leakage can be difficult to observe unless the active compound give rise to discoloration, which per se can create problems of psychological and/or cosmetic art.
A solution to above problems is for instance a dressing set comprising an occlusive backing. This is, however, in most cases unacceptable from a medical point of view, especially in treatment of wounds requiring a non-occlusive dressing. An occlusive backing prevents the necessary ventilation of the wound and increases the moisture in and on the skin covered by the dressing thus causing maceration.
Dressing sets comprising an occlusive barrier located in for instance a pocket or the like between a drug reservoir and a non-occlusive backing, is also known. The barrier is in such a case removed before applying the dressing set, whereby a non-occlusive dressing is obtained. The solution to above problems give, however, rise to certain drawbacks, such as production obstacles, adhesion between the reservoir and/or the backing and the barrier with resulting difficulties in removing said barrier, and unnecessary handling of the dressing possibly resulting in contamination thereof.
Disclosed problems and drawbacks have quite unexpectedly been solved or substantially reduced by the present invention, which relates to a dressing set, primarily intended for wound dressings but also useful for TDDS and other applications including dressing sets. The dressing set according to the present invention comprises i) a substantially non-occlusive and preferably adhesive backing, ii) a compress, swab, matrix or similar reservoir comprising one or more layers and at least one pharmaceutically active compound, iii) one or more peel strips, release papers or the like, and iv) a foil having an area being larger or at least equal to the area of said reservoir, which foil is located between said reservoir and said backing The foil is made of at least one hydrophilic or hydrophilized polymer and is in a moisture free state substantially occlusive and after absorption of moisture substantially non-occlusive.
The moisture free, that is the dry and unused, occlusive foil works during storage of the dressing set as a barrier towards migration and other type of leakage into or through the backing. The active compound in the reservoir can thus be kept at a substantially constant level, whereby the storage time can be prolonged and problems related to uncertainty regarding available amount of active compound or compounds can substantially be eliminated. Handling and health hazards related to drug impregnated or otherwise drug containing packages, as may be the result of migration or leakage, are furthermore reduced or eliminated. The dressing of the present invention also opens the possibility of including into the reservoir compounds now regarded as impossible to include due to discussed problems.
The foil will when used, that is applied onto the skin of a patient, absorb moisture from or via the skin and thus obtain non-occlusive properties, whereby the entire dressing set will be substantially non-occlusive. The non-occlusive properties are as previously disclosed of vital importance in for instance the treatment of various wounds and other therapies requiring ventilation or air supply in general.
The present invention facilitates the productions of or even makes it possible produce dressing sets intended for antiseptic and chemotherapeutic treatment of wounds. The conventionally used drug containing compresses, swabs and the like are advantageously replaced by a dressing set according to the present invention, especially when the pharmaceutically active compound without a barrier is likely to migrate through, interact with or give rise to discoloration of a non-occlusive backing material. A dressing set facilitates, in comparison to compresses or the like, both handling and therapeutic treatment.
Most hydrophilic or hydrophilized polymers, being non-occlusive in a dry state and being pharmaceutically acceptable as well as inert to the pharmaceutically active compound or compounds, can be used to produce the foil included in the dressing set of the present invention. Especially suitable and in various embodiments preferred polymers can be exemplified by hydrophilized polyurethanes, agar, agarose and/or derivatives thereof or by crosslinked dextrine, starch, dextran, cellulose, poly(vinyl alcohol), poly(acrylamide), poly(vinyl pyrrolidone) and/or derivatives thereof.
The dressing set of the present invention comprises preferably one or more peel strips, release papers or the like, which preferably are made of for example a siliconized pharmaceutically acceptable polymer foil or siliconized paper.
The dressing set of the present invention is especially suitable for wound dressings having a reservoir containing one or more antiseptic and/or chemotherapeutic compounds, such as cadexomer iodine, framycetin, fusidic acid and/or derivatives thereof as well as mixtures thereof and therewith. Further suitable application areas of the dressing set according to the present invention include TDDS comprising for example nitro-glycerine, nicotine, scopolamine, cestrogenes and/or prostaglandines.
These and other objects and the attendant advantages will be more fully understood from the following detailed description, taken in conjunction with appended Figures, wherein like reference numerals have been applied to like parts throughout the Figures and wherein:
- Figure 1 is flat view of an embodiment of a dressing set according to the present invention. The dressing set is shown from a side comprising a drug reservoir under which a foil barrier is located.
- Figure 2 is a side of the same embodiment of a dressing set as shown in Figure 1.
Figure 1 shows a flat view of an embodiment of a dressing set 1 according the present invention. The dressing set 1 comprises a non-occlusive backing 2 having one adhesive side 4, in this case turned towards the viewer, a reservoir 3 of type compress comprising a pharmaceutically active compound and a foil 5 located between the reservoir 3 and the backing 2. The foil 5 consists of a hydrophilized polyurethane being occlusive is in a dry, moisture free state, whereby migration or leakage of the pharmaceutically active compound in the reservoir 3 into or through the backing 2 is prevented.
Figure 2 shows in a side view the same embodiment of a dressing set 1 according to the present invention as Figure 1. The dressing set accordingly comprises a non-occlusive backing 2 having one adhesive side 4, a drug reservoir 3 and a foil 5, made from a hydrophilized polyurethane and located between the reservoir 3 and the adhesive side 4 of the backing 2. The dressing set 1 also includes two release papers 6 made of siliconized paper.
The various parts shown in Figures 1 and 2 are not entirely according to scale. Some parts are for the sake of clarity enlarged or reduced. Optional peel strips or release papers 6 are for reason of simplicity not included in Figure 1.
While a particular embodiment of the invention has been shown, it will be understood, of course, that the invention is not limited thereto since many modifications may be made, and it is, therefore, contemplated to cover by the appended claims any such modifications as fall within the true spirit and scope of the invention.
Claims
1. A dressing set (1) comprising a non-occlusive backing (2), which backing (2) optionally has at least one adhesive side (4), a reservoir (3), which reservoir (3) in area is smaller than or at most equal to the backing (2) and which reservoir (3) comprises one or more layers and at least one pharmaceutically active compound, and optionally one or more peel strips, release papers (6) or similar arrangement protecting the reservoir (3) and/or the optional adhesive side (4) of said backing (2) characterized in, that a) a foil (5) having an area being larger than or at least equal to the area of the reservoir (3) is located between the reservoir (3) and the backing (2), b) the foil (5) consists of at least one hydrophilic or hydrophilized polymer, c) the foil (5) in a dry, moisture free state is substantially occlusive, and d) the foil (5) after moisture absorption is substantially non-occlusive.
2. A dressing set (1) according to Claim 1 characterized in, that the foil (5) consists of at least one hydrophilized polyurethane.
3. A dressing set (1) according to Claim 1 characterized in, that the foil (5) consists agar, agarose and/or at least one derivative thereof.
4. A dressing set (1) according to Claim 1 characterized in, that the foil (5) comprises of at least one polymer selected from the group consisting of crosslinked dextrine, starch, dextran, cellulose and derivatives thereof.
5. A dressing set (1) according to Claim 1 characterized in, that the foil (5) comprises of at least one polymer selected from the group consisting of crosslinked poly(vinyl alcohol), poly(acrylamide), poly(vinyl pyrrolidone) and derivatives thereof.
6. A dressing set (1) according to any of the Claims 1-5 characterized in, that the dressing set (1) comprises at least one peel strip or release paper (6) made of a siliconized pharmaceutically acceptable polymer or siliconized paper.
7. A dressing set (1) according to any of the Claims 1-6 characterized in, that the reservoir (3) is made up of at least one compress or swab.
8. A dressing set (1) according to any of the Claims 1-7 characterized in, that the reservoir (3) comprises at least one pharmaceutically active compound or preparation having antiseptic and/or chemotherapeutic effect.
9. A dressing set (1) according to any of the Claims 1-8 characterized in, that the reservoir (3) comprises at least one pharmaceutically active compound selected from the group consisting of cadexomer iodine, framycetin, fusidic acid and derivatives thereof.
10. A dressing set (1) according to Claim 9 characterized in, that the dressing set (1) is a wound dressing.
11. A dressing set (1) according to any of the Claims 1-8 characterized in, that the reservoir (3) comprises at least one pharmaceutically active compound selected from the group consisting of nitro-glycerine, nicotine, scopolamine, cestrogenes, prostaglandines and derivatives thereof.
12. A dressing set (1) according to Claim 11 characterized in, that the dressing set (1) is a so called Transdermal Drug Delivery System (TDDS).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU57084/96A AU5708496A (en) | 1995-05-05 | 1996-05-02 | Dressing set |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9501670A SE503432C2 (en) | 1995-05-05 | 1995-05-05 | Omläggningsset |
SE9501670-5 | 1995-05-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996034633A1 true WO1996034633A1 (en) | 1996-11-07 |
Family
ID=20398206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1996/000567 WO1996034633A1 (en) | 1995-05-05 | 1996-05-02 | Dressing set |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU5708496A (en) |
SE (1) | SE503432C2 (en) |
WO (1) | WO1996034633A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19736315A1 (en) * | 1997-08-21 | 1999-02-25 | Lohmann Therapie Syst Lts | Active agent containing device, for dermal use |
DE19925519A1 (en) * | 1999-06-04 | 2000-12-07 | Lohmann Therapie Syst Lts | Laminar wound dressing for controlled release of active substance e.g. platelet derived growth factor, includes layer containing polymer and hydrogel as fluid absorber |
WO2000074660A2 (en) * | 1999-06-02 | 2000-12-14 | Lts Lohmann Therapie-Systeme Ag | Substrate sections with improved storage stability during their storage in bags, and a method for producing the same |
EP1063543A1 (en) * | 1999-06-25 | 2000-12-27 | Lucent Technologies Inc. | Device for smoothing of optical fiber ends using a solvent liner and surface tension |
US6841574B2 (en) * | 2003-01-03 | 2005-01-11 | Nexmed Holdings, Inc. | Topical stabilized prostaglandin E compound dosage forms |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0249343A1 (en) * | 1986-06-13 | 1987-12-16 | Alza Corporation | Moisture activation of transdermal drug delivery system |
US5411740A (en) * | 1992-05-13 | 1995-05-02 | Alza Corporation | Transdermal administration of oxybutynin |
-
1995
- 1995-05-05 SE SE9501670A patent/SE503432C2/en not_active IP Right Cessation
-
1996
- 1996-05-02 AU AU57084/96A patent/AU5708496A/en not_active Abandoned
- 1996-05-02 WO PCT/SE1996/000567 patent/WO1996034633A1/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0249343A1 (en) * | 1986-06-13 | 1987-12-16 | Alza Corporation | Moisture activation of transdermal drug delivery system |
US5411740A (en) * | 1992-05-13 | 1995-05-02 | Alza Corporation | Transdermal administration of oxybutynin |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19736315A1 (en) * | 1997-08-21 | 1999-02-25 | Lohmann Therapie Syst Lts | Active agent containing device, for dermal use |
WO2000074660A2 (en) * | 1999-06-02 | 2000-12-14 | Lts Lohmann Therapie-Systeme Ag | Substrate sections with improved storage stability during their storage in bags, and a method for producing the same |
WO2000074660A3 (en) * | 1999-06-02 | 2001-06-28 | Lohmann Therapie Syst Lts | Substrate sections with improved storage stability during their storage in bags, and a method for producing the same |
JP2003501380A (en) * | 1999-06-02 | 2003-01-14 | エルテーエス ローマン テラピー−ジステーメ アーゲー | Substrate portion having improved storage stability during storage in bag packaging and method for producing the same |
KR100599235B1 (en) * | 1999-06-02 | 2006-07-13 | 에르테에스 로만 테라피-시스테메 아게 | Substrate sections with improved storage stability during their storage in bags, and a method for producing the same |
JP2012111949A (en) * | 1999-06-02 | 2012-06-14 | Lts Lohmann Therapie-Systeme Ag | Substrate section with improved storage stability during storage in bag packaging, and method for manufacturing thereof |
DE19925519A1 (en) * | 1999-06-04 | 2000-12-07 | Lohmann Therapie Syst Lts | Laminar wound dressing for controlled release of active substance e.g. platelet derived growth factor, includes layer containing polymer and hydrogel as fluid absorber |
EP1063543A1 (en) * | 1999-06-25 | 2000-12-27 | Lucent Technologies Inc. | Device for smoothing of optical fiber ends using a solvent liner and surface tension |
US6500353B1 (en) | 1999-06-25 | 2002-12-31 | Fitel Usa Corp. | Disposable device for end finishing of plastic optical fiber |
US6841574B2 (en) * | 2003-01-03 | 2005-01-11 | Nexmed Holdings, Inc. | Topical stabilized prostaglandin E compound dosage forms |
Also Published As
Publication number | Publication date |
---|---|
AU5708496A (en) | 1996-11-21 |
SE9501670D0 (en) | 1995-05-05 |
SE9501670L (en) | 1996-06-10 |
SE503432C2 (en) | 1996-06-10 |
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