WO1992013570A3 - Novel complexes containing nucleic acid which can be absorbed into higher eucaryotic cells via endocytosis - Google Patents
Novel complexes containing nucleic acid which can be absorbed into higher eucaryotic cells via endocytosis Download PDFInfo
- Publication number
- WO1992013570A3 WO1992013570A3 PCT/EP1992/000217 EP9200217W WO9213570A3 WO 1992013570 A3 WO1992013570 A3 WO 1992013570A3 EP 9200217 W EP9200217 W EP 9200217W WO 9213570 A3 WO9213570 A3 WO 9213570A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acid
- eucaryotic cells
- absorbed
- higher eucaryotic
- complexes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92903641A EP0571414B1 (en) | 1991-02-12 | 1992-02-01 | Novel complexes containing nucleic acid which can be absorbed into higher eucaryotic cells via endocytosis |
DE59207189T DE59207189D1 (en) | 1991-02-12 | 1992-02-01 | NEW COMPLEXES CONTAINED BY ENDOCYTOSIS IN HIGHER EUKARYOTIC CELLS, NUCLEIC ACID |
US08/098,265 US5922859A (en) | 1992-02-01 | 1992-02-01 | Complexes containing nucleic acid which can be taken-up by endocytosis into higher eukaryotic cells |
JP4503508A JPH06504993A (en) | 1991-02-12 | 1992-02-01 | Novel nucleic acid-containing complexes that can be taken up by higher eukaryotic cells by endocytosis |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4104186A DE4104186A1 (en) | 1991-02-12 | 1991-02-12 | NEW COMPLEXES INCLUDING ENDOCYTOSIS IN HIGHER EUKARYOTIC CELLS, NUCLEIC ACID |
DEP4104186.0 | 1991-02-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1992013570A2 WO1992013570A2 (en) | 1992-08-20 |
WO1992013570A3 true WO1992013570A3 (en) | 1992-10-29 |
Family
ID=6424859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1992/000217 WO1992013570A2 (en) | 1991-02-12 | 1992-02-01 | Novel complexes containing nucleic acid which can be absorbed into higher eucaryotic cells via endocytosis |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0571414B1 (en) |
JP (1) | JPH06504993A (en) |
AT (1) | ATE142890T1 (en) |
DE (2) | DE4104186A1 (en) |
ES (1) | ES2094342T3 (en) |
WO (1) | WO1992013570A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8945884B2 (en) | 2000-12-11 | 2015-02-03 | Life Technologies Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiplerecognition sites |
US9358300B2 (en) | 1998-11-12 | 2016-06-07 | Life Technologies Corporation | Transfection reagents |
US9534252B2 (en) | 2003-12-01 | 2017-01-03 | Life Technologies Corporation | Nucleic acid molecules containing recombination sites and methods of using the same |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6022950A (en) * | 1984-06-07 | 2000-02-08 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
US5977307A (en) * | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
US5672683A (en) * | 1989-09-07 | 1997-09-30 | Alkermes, Inc. | Transferrin neuropharmaceutical agent fusion protein |
US5527527A (en) * | 1989-09-07 | 1996-06-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
AU675057B2 (en) * | 1989-09-07 | 1997-01-23 | Alkermes, Inc. | Process for the preparation of transferrin receptor specificantibody-neuropharmaceutical or diagnostic agent conjugates |
US5830686A (en) * | 1994-01-13 | 1998-11-03 | Calydon | Tissue-specific enhancer active in prostate |
US6057299A (en) * | 1994-01-13 | 2000-05-02 | Calydon, Inc. | Tissue-specific enhancer active in prostate |
FR2719316B1 (en) * | 1994-04-28 | 1996-05-31 | Idm | New nucleic acid and polymer complexes, their preparation process and their use for cell transfection. |
JPH0889278A (en) * | 1994-09-29 | 1996-04-09 | Ajinomoto Co Inc | Modified protein for introducing gene and its production |
US6015555A (en) * | 1995-05-19 | 2000-01-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates |
EP0874910A4 (en) * | 1995-06-07 | 1999-04-21 | Life Technologies Inc | Peptide-enhanced cationic lipid transfections |
US6051429A (en) | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
FR2736642B1 (en) * | 1995-07-10 | 1997-09-12 | Pasteur Institut | IMMUNOVECTORS, IN PARTICULAR ANTIBODIES AND FRAGMENTS OF ANTIBODIES FOR USE IN THE INTRACELLULAR AND INTRANUCLEAR TRANSPORT OF BIOLOGICALLY ACTIVE PRINCIPLES IN PARTICULAR OF HAPTENES, PROTEINS AND NUCLEIC ACIDS |
FR2755976B1 (en) * | 1996-11-15 | 1999-01-15 | Idm Immuno Designed Molecules | NOVEL COMPLEXES OF NUCLEIC ACIDS AND POLYMER SUBSTITUTED BY RESIDUES CAUSING THE DESTABILIZATION OF CELL MEMBRANES |
WO1999006576A1 (en) | 1997-08-04 | 1999-02-11 | Calydon, Inc. | A human glandular kallikrein enhancer, vectors comprising the enhancer and methods of use thereof |
US6927278B1 (en) * | 1998-09-01 | 2005-08-09 | Trustees Of The University Of Pennsylvania | Peptide scaffolds for transfer of molecules into eukaryotic cells |
US6902933B2 (en) * | 2000-11-03 | 2005-06-07 | Regents Of The University Of Michigan | Surface transfection and expression procedure |
WO2004096117A2 (en) * | 2003-05-02 | 2004-11-11 | Xpression Antibody Therapeutics, Inc. | Drug delivery systems comprising transferrin-nucleic acid conjugates |
WO2008073856A2 (en) * | 2006-12-08 | 2008-06-19 | Massachusetts Institute Of Technology | Delivery of nanoparticles and/or agents to cells |
KR102112892B1 (en) | 2012-11-15 | 2020-05-19 | 로슈 이노베이션 센터 코펜하겐 에이/에스 | Oligonucleotide conjugates |
EP3142673A4 (en) | 2014-05-14 | 2018-01-03 | Targlmmune Therapeutics AG | Improved polyethyleneimine polyethyleneglycol vectors |
US10195280B2 (en) | 2014-07-15 | 2019-02-05 | Life Technologies Corporation | Compositions and methods for efficient delivery of molecules to cells |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0387775A1 (en) * | 1989-03-16 | 1990-09-19 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Genetic construct for inhibiting RNA function |
EP0388758A1 (en) * | 1989-03-16 | 1990-09-26 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Protein-polycation conjugate |
WO1991017773A2 (en) * | 1990-05-18 | 1991-11-28 | Boehringer Ingelheim International Gmbh | New protein-polycation conjugates |
-
1991
- 1991-02-12 DE DE4104186A patent/DE4104186A1/en not_active Withdrawn
-
1992
- 1992-02-01 AT AT92903641T patent/ATE142890T1/en not_active IP Right Cessation
- 1992-02-01 EP EP92903641A patent/EP0571414B1/en not_active Expired - Lifetime
- 1992-02-01 JP JP4503508A patent/JPH06504993A/en active Pending
- 1992-02-01 ES ES92903641T patent/ES2094342T3/en not_active Expired - Lifetime
- 1992-02-01 DE DE59207189T patent/DE59207189D1/en not_active Expired - Fee Related
- 1992-02-01 WO PCT/EP1992/000217 patent/WO1992013570A2/en active IP Right Grant
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0387775A1 (en) * | 1989-03-16 | 1990-09-19 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Genetic construct for inhibiting RNA function |
EP0388758A1 (en) * | 1989-03-16 | 1990-09-26 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Protein-polycation conjugate |
WO1991017773A2 (en) * | 1990-05-18 | 1991-11-28 | Boehringer Ingelheim International Gmbh | New protein-polycation conjugates |
Non-Patent Citations (2)
Title |
---|
Bioconjugate Chem., Band 2, Nr. 4, Juli/August 1991, American Chemical Society, (Washington, DC, US), E. WAGNER et al.: "DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety", Seiten 226-231, siehe das ganze Dokument (in der Anmeldung erwähnt) * |
Proc. Natl. Acad. Sci. USA, Band 87, Mai 1990, (Washington, DC, US), E. WAGNER et al.: "Transferrin-polycation conjugates as carriers for DNA uptake into cells", Seiten 3410-3414, siehe das ganze Dokument * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9358300B2 (en) | 1998-11-12 | 2016-06-07 | Life Technologies Corporation | Transfection reagents |
US9309520B2 (en) | 2000-08-21 | 2016-04-12 | Life Technologies Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
US8945884B2 (en) | 2000-12-11 | 2015-02-03 | Life Technologies Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiplerecognition sites |
US9534252B2 (en) | 2003-12-01 | 2017-01-03 | Life Technologies Corporation | Nucleic acid molecules containing recombination sites and methods of using the same |
Also Published As
Publication number | Publication date |
---|---|
ES2094342T3 (en) | 1997-01-16 |
DE59207189D1 (en) | 1996-10-24 |
EP0571414B1 (en) | 1996-09-18 |
ATE142890T1 (en) | 1996-10-15 |
WO1992013570A2 (en) | 1992-08-20 |
EP0571414A1 (en) | 1993-12-01 |
JPH06504993A (en) | 1994-06-09 |
DE4104186A1 (en) | 1992-08-13 |
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