WO1987005300A3 - Protein preservation - Google Patents

Protein preservation Download PDF

Info

Publication number
WO1987005300A3
WO1987005300A3 PCT/GB1987/000143 GB8700143W WO8705300A3 WO 1987005300 A3 WO1987005300 A3 WO 1987005300A3 GB 8700143 W GB8700143 W GB 8700143W WO 8705300 A3 WO8705300 A3 WO 8705300A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein preservation
preservation
protein
water
dependant
Prior art date
Application number
PCT/GB1987/000143
Other languages
French (fr)
Other versions
WO1987005300A2 (en
Inventor
James Arthur Hayward
David Samuel Johnston
Original Assignee
Biocompatibles Ltd
James Arthur Hayward
David Samuel Johnston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles Ltd, James Arthur Hayward, David Samuel Johnston filed Critical Biocompatibles Ltd
Publication of WO1987005300A2 publication Critical patent/WO1987005300A2/en
Publication of WO1987005300A3 publication Critical patent/WO1987005300A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A process for preserving a material having water-dependant structure comprising contacting the material with an aqueous solution of a polyhydroxy compound then removing water from the material.
PCT/GB1987/000143 1986-02-28 1987-02-27 Protein preservation WO1987005300A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868604983A GB8604983D0 (en) 1986-02-28 1986-02-28 Protein preservation
GB8604983 1986-02-28

Publications (2)

Publication Number Publication Date
WO1987005300A2 WO1987005300A2 (en) 1987-09-11
WO1987005300A3 true WO1987005300A3 (en) 1987-10-22

Family

ID=10593832

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1987/000143 WO1987005300A2 (en) 1986-02-28 1987-02-27 Protein preservation

Country Status (4)

Country Link
EP (1) EP0259425A1 (en)
JP (1) JPS63502592A (en)
GB (1) GB8604983D0 (en)
WO (1) WO1987005300A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877162B2 (en) 2000-05-10 2014-11-04 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery
US9421166B2 (en) 2001-12-19 2016-08-23 Novartis Ag Pulmonary delivery of aminoglycoside
US9554993B2 (en) 1997-09-29 2017-01-31 Novartis Ag Pulmonary delivery particles comprising an active agent

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8715238D0 (en) * 1987-06-29 1987-08-05 Quadrant Bioresources Ltd Food process
GB8801338D0 (en) * 1988-01-21 1988-02-17 Quadrant Bioresources Ltd Preservation of viruses
US5045446A (en) * 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
US5958670A (en) * 1988-05-18 1999-09-28 Cobe Laboratories, Inc. Method of freezing cells and cell-like materials
ATE107502T1 (en) * 1988-10-05 1994-07-15 Vestar Inc METHOD OF PREPARING LIPOSOMES WITH IMPROVED STABILITY DURING DRYING.
US5059518A (en) * 1988-10-20 1991-10-22 Coulter Corporation Stabilized lyophilized mammalian cells and method of making same
US5030560A (en) * 1988-11-04 1991-07-09 Immucor, Inc. Method for drying mammalian cells for use in solid phase immunoassays and articles incorporating same
US5192663A (en) * 1988-11-04 1993-03-09 Immucor, Inc. Article having an organic dye and a monolayer of dried mammalian cells and a method for utilizing the article
USRE39497E1 (en) 1989-02-16 2007-02-27 Nektar Therapeutics Storage of materials
GB8903593D0 (en) 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
FR2645741B1 (en) * 1989-03-20 1995-06-23 Dior Christian Parfums PROCESS FOR FIXING A PRODUCT ON THE MEMBRANE OF A KERATINOCYTE BY MEANS OF A LIGAND-RECEPTOR BINDING, PROCESS FOR PREPARING SUCH A PRODUCT, PRODUCT OBTAINED, COSMETIC OR PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHOD FOR PREPARING THE SAME
ZA902663B (en) * 1989-04-07 1991-12-24 Syntex Inc Interleukin-1 formulation
IE64738B1 (en) * 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations
US5384132A (en) * 1990-03-20 1995-01-24 Akzo N.V. Stabilized gonadotropin containing preparations
US5270057A (en) * 1990-03-20 1993-12-14 Akzo N.V. Stabilized gonadotropin containing preparations
GB9010742D0 (en) * 1990-05-14 1990-07-04 Quadrant Bioresources Ltd Stabilization of biological macromolecular substances
JPH05505680A (en) * 1991-01-11 1993-08-19 コーブ　ラボラトリーズ　インコーポレイテッド Methods for Assaying Circulating Antibody Types Using Dried or Lyophilized Cells or Cell-Like Materials
AU659645B2 (en) 1991-06-26 1995-05-25 Inhale Therapeutic Systems Storage of materials
CA2128527A1 (en) * 1992-01-21 1993-07-22 Raymond P. Goodrich, Jr. Method of freezing cells and cell-like materials
CZ296649B6 (en) * 1993-02-23 2006-05-17 Genentech, Inc. Process for preparing stabilized polypeptide composition comprising stabilizing polypeptide against denaturation when treated with organic solvents, preparation of the polypeptide and composition for controlled release of polypeptide
DE69420876T2 (en) 1993-03-18 2000-04-20 Terumo Corp Encapsulated hemoglobin liposome and process for its preparation
US5674528A (en) * 1994-06-15 1997-10-07 Terumo Kabushiki Kaisha Hemoglobin-encapsulated liposome
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6309671B1 (en) 1995-04-14 2001-10-30 Inhale Therapeutic Systems Stable glassy state powder formulations
GB9508691D0 (en) 1995-04-28 1995-06-14 Pafra Ltd Stable compositions
HUP9901716A3 (en) * 1995-06-07 2000-04-28 Quadrant Holdings Cambridge Methods for stably incorporating substances within dry, foamed glass matrices and compositions obtained thereby
US6632648B1 (en) 1996-05-14 2003-10-14 Elan Drug Delivery Limited Methods of terminal sterilization of fibrinogen
US6468782B1 (en) 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
DK0967862T3 (en) * 1997-02-07 2003-05-12 Elan Drug Delivery Ltd Methods and compositions for preparing dried, storage-stable platelets
US6770478B2 (en) 2000-02-10 2004-08-03 The Regents Of The University Of California Erythrocytic cells and method for preserving cells
EP1255439A4 (en) 2000-02-10 2007-01-03 Univ California Therapeutic platelets and methods
US8409587B2 (en) * 2002-11-01 2013-04-02 Glaxosmithkline Biologicals S.A. Immunogenic composition
ES2502691B1 (en) * 2013-09-25 2015-07-07 Sani-Red, S.L. Protein preservation and stabilization method, applicable for industrial developments of medical, pharmaceutical and cosmetic formulations
WO2016209907A1 (en) 2015-06-25 2016-12-29 The Regents Of The University Of California Stable support films for electron microscopy

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1855591A (en) * 1926-02-03 1932-04-26 Wallerstein Co Inc Invertase preparation and method of making the same
FR2532178A1 (en) * 1982-08-31 1984-03-02 Asahi Chemical Ind PROCESS FOR STABILIZING TUMOR NECROSIS FACTOR AND AQUEOUS SOLUTION OR STABLE POWDER CONTAINING THE SAME
EP0111216A2 (en) * 1980-03-31 1984-06-20 Takeda Chemical Industries, Ltd. Method for enzyme immunoassay and peptide-enzyme conjugate, its lyophilizate, antibody and kit therefor
WO1986001103A1 (en) * 1984-08-08 1986-02-27 The Liposome Company, Inc. Dehydrated liposomes
WO1986003938A1 (en) * 1985-01-11 1986-07-17 The Regents Of The University Of California Method for preserving liposomes
WO1987000196A1 (en) * 1985-07-09 1987-01-15 Quadrant Bioresources Limited Protection of proteins and the like

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1855591A (en) * 1926-02-03 1932-04-26 Wallerstein Co Inc Invertase preparation and method of making the same
EP0111216A2 (en) * 1980-03-31 1984-06-20 Takeda Chemical Industries, Ltd. Method for enzyme immunoassay and peptide-enzyme conjugate, its lyophilizate, antibody and kit therefor
FR2532178A1 (en) * 1982-08-31 1984-03-02 Asahi Chemical Ind PROCESS FOR STABILIZING TUMOR NECROSIS FACTOR AND AQUEOUS SOLUTION OR STABLE POWDER CONTAINING THE SAME
WO1986001103A1 (en) * 1984-08-08 1986-02-27 The Liposome Company, Inc. Dehydrated liposomes
WO1986003938A1 (en) * 1985-01-11 1986-07-17 The Regents Of The University Of California Method for preserving liposomes
WO1987000196A1 (en) * 1985-07-09 1987-01-15 Quadrant Bioresources Limited Protection of proteins and the like

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Archives of Biochemistry and Biophysics", Volume 242, No. 1, October 1985, Academic Press, Inc. L.M. CROWE et al.: "Preservation of Freeze-Dried Liposomes by Trehalose", pages 240-247, see the whole document *
Biochemistry, Volume 24, 1985, American Chemical Society, (Washington, US), J. SZEBENI et al.: "Encapsulation of Hemoglobin in Phospholipid Liposomes: Characterization and Stability", pages 2827-2832, see pages 2827-2828 cited in the application *
CHEMICAL ABSTRACTS, Volume 103, No. 12, 23 September 1985, (Columbus, Ohio, US) T.D. MADDEN et al.: "Protection of Large Unilamellar Vesicles by Trehalose During Dehydration: Retention of Vesicle Contents", see page 316, Abstract 92759a, & Biochim. Biophys, Acta 198k, 817(1), 67-74 cited in the application *
CHEMICAL ABSTRACTS, Volume 85, No. 3, 19 July 1976, (Columbus, Ohio, US), P. LABRUDE et al.: "Lyophilization of Hemoglobin Solutions. Study of Protector Compounds Capable of Preventing the Formation of Methemoglobin", see page 415, Abstract 18011u, & J. Pharm. Belg. 1976, 31(2), 191-8 *
Science, Volume 223, No. 4637, 17 February 1984, American Association for the Advancement of Science, (Washington, US), J.H. CROWE et al.: "Preservation of Membranes in Anhydrobiotic Organisms: the role of Trehalose", pages 701-703, see the whole document cited in the application *
The Proceedings of Biotech '84 Europe, Volume 1, American Chemical Society "World Biotech Report 1984", pages 379-390, see pages 382-385 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9554993B2 (en) 1997-09-29 2017-01-31 Novartis Ag Pulmonary delivery particles comprising an active agent
US8877162B2 (en) 2000-05-10 2014-11-04 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery
US9439862B2 (en) 2000-05-10 2016-09-13 Novartis Ag Phospholipid-based powders for drug delivery
US9421166B2 (en) 2001-12-19 2016-08-23 Novartis Ag Pulmonary delivery of aminoglycoside

Also Published As

Publication number Publication date
GB8604983D0 (en) 1986-04-09
EP0259425A1 (en) 1988-03-16
JPS63502592A (en) 1988-09-29
WO1987005300A2 (en) 1987-09-11

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