US20200289765A1 - Plunger covers and plungers for use in syringes - Google Patents
Plunger covers and plungers for use in syringes Download PDFInfo
- Publication number
- US20200289765A1 US20200289765A1 US16/946,008 US202016946008A US2020289765A1 US 20200289765 A1 US20200289765 A1 US 20200289765A1 US 202016946008 A US202016946008 A US 202016946008A US 2020289765 A1 US2020289765 A1 US 2020289765A1
- Authority
- US
- United States
- Prior art keywords
- plunger
- central portion
- sealing portion
- cover
- plunger cover
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31515—Connection of piston with piston rod
Definitions
- the present invention relates generally to plunger covers and to plungers for use in syringes and to methods of fabrication of plunger covers and plungers for use in syringes, and particularly, to plunger covers and to plungers for use in syringes to inject fluids into a patient and to methods of fabrication thereof.
- a number of injector-actuated syringes and powered injectors for use in medical procedures such as angiography, computed tomography, ultrasound and magnetic resonance imaging (MRI) have been developed.
- injectors comprise drive members such as pistons that operatively connect to a syringe plunger.
- a common method of manufacturing syringe plungers adapted, for example, for use in connection with powered injectors is to place an elastomeric, sealing plunger cover over a rigid base.
- Such rubber covers can, for example, be manufactured by a vulcanization compression molding process. The rubber covers can, for example, be molded into a sheet and then manually hand cut (through a cutting die) from the sheet. Once cut, the rubber covers are, for example, washed in a silicone wash and then assembled onto a plunger base for insertion into a syringe. The process results in substantial material waste and can also result in substantial manufacturing costs and time.
- U.S. Pat. No. 5,902,276 discloses a syringe plunger that is formed by a two-shot molding process.
- a hard plastic core is first formed in a first mold.
- the distal portion of the hard plastic core is overmolded with a soft rubber plunger cover in a second mold.
- the second overmolding can occur in the second mold while the core is still cooling to effect molecular bonding of the rubber of the cover with the as-yet uncured plastic of the core.
- the plunger includes at least two parts.
- the plunger includes a plunger body made of a first plastic and a piston body (in the form of a sealing cover) at the front of the plunger body made of a second plastic.
- the second plastic an elastomer
- the piston body is first formed by injection molding. Then, the plunger body (or a part thereof) is injected molded against or over the piston body.
- the present invention provides a plunger cover for use with a syringe including a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe.
- the central portion can, for example, be more rigid than the sealing portion.
- the sealing portion and the central portion are connected in an overmolding process.
- the sealing portion can, for example, be formed from a thermoplastic elastomer or a thermoplastic polyurethane.
- the central portion can, for example, be formed from polypropylene, acrylonitrile butadiene styrene, polycarbonate or copolymers thereof.
- the sealing portion is injection molded first and the central portion is injection overmolded thereon. In other embodiments, the central portion is injection molded first and the sealing portion is injection overmolded thereon. In several preferred embodiments, the sealing portion is injection molded first and the central portion is injection overmolded thereon.
- the material for the sealing portion and the material for the central portion can be selected so that molecular bonding occurs between the sealing portion and the central portion.
- the present provides a plunger for use with a syringe including a plunger cover including a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe as described above.
- the central portion can, for example, be more rigid than the sealing portion.
- the sealing portion and the central portion are connected in an overmolding process.
- the plunger further includes a support attached to the plunger cover.
- the sealing portion can, for example, includes a radially inward projecting flange that is seated within a seating formed on the support to connect the plunger cover to the support.
- the support can, for example, include a forward surface adapted to abut the plunger cover to prevent rearward motion of the central portion relative to the support.
- the present invention provides a syringe including a syringe body and a plunger slidably positioned within the syringe body.
- the plunger includes a plunger cover including a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe.
- the central portion can, for example, be more rigid than the sealing portion.
- the sealing portion and the central portion are connected in an overmolding process.
- the plunger further includes a support attached to the plunger cover.
- the present invention provides a method of fabricating a plunger cover for use in a syringe, including: connecting a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe in an overmolding process, the central portion being more rigid than the sealing portion.
- the sealing portion can, for example, be injection molded first and the central portion is injection overmolded thereon.
- the central portion can be injection molded first and the sealing portion is injection overmolded thereon.
- the present invention provides a plunger cover for use with a syringe including a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe.
- the central portion has at least one physiochemical property that differs from the sealing portion.
- the sealing portion and the central portion are connected in an overmolding process.
- the present invention provides a plunger cover for use with a syringe including a sealing portion adapted to form a seal with the syringe and a central portion.
- the central portion is more rigid than the sealing portion.
- the sealing portion and the central portion being connected in an overmolding process.
- the central portion is positioned forward of at least a portion of the sealing portion and is adapted to contact fluid within the syringe.
- the central portion is positioned rearward of a generally central section of the sealing portion and does not contact fluid within the syringe.
- the central portion can, for example, be overmolded upon the sealing portion.
- the central portion can be injection molded first and the sealing portion is injection overmolded thereon.
- the present invention provides a plunger for use with a syringe including a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe.
- the central portion is, for example, more rigid than the sealing portion.
- the sealing portion and the central portion are connected in an overmolding process.
- the sealing portion can, for example, be adapted to form an operative connection with a drive member.
- FIG. 1A illustrates a perspective view of an embodiment of a plunger of the present invention.
- FIG. 1B illustrates a perspective cutaway view of the plunger of FIG. 1A .
- FIG. 1C illustrates an enlarged cutaway view of a portion of the plunger of FIG. 1A .
- FIG. 1D illustrates a rear perspective, exploded view of the plunger of FIG. 1A wherein the plunger cover is disconnected from the base.
- FIG. 1E illustrates a front perspective, exploded view of the plunger of FIG. 1A wherein the plunger cover is disconnected from the base.
- FIG. 1F illustrates a side schematic view of the plunger of FIG. 1A slidably positioned within a syringe that is removably attached to a powered injector.
- FIG. 2A illustrates a perspective view of another embodiment of a plunger of the present invention.
- FIG. 2B illustrates a perspective cutaway view of the plunger of FIG. 2A .
- FIG. 2C illustrates an enlarged perspective cutaway view of a portion of the plunger of FIG. 2A .
- FIG. 2D illustrates a rear perspective, exploded view of the plunger of FIG. 2A wherein the plunger cover is disconnected from the base.
- FIG. 2E illustrates a front perspective, exploded view of the plunger of FIG. 2A wherein the plunger cover is disconnected from the base.
- FIG. 3A illustrates a perspective view of another embodiment of a plunger of the present invention.
- FIG. 3B illustrates a perspective cutaway view of the plunger of FIG. 3A .
- FIG. 3C illustrates a front perspective, exploded view of the plunger of FIG. 3A wherein the plunger cover is disconnected from the base and the sealing portion of the plunger cover is separated from the central or cone portion of the plunger cover.
- FIG. 3D illustrates a rear perspective, exploded view of the plunger of FIG. 3A wherein the plunger cover is disconnected from the base and the sealing portion of the plunger cover is separated from the central or cone portion of the plunger cover.
- FIG. 3E illustrates a front perspective view of the sealing portion of the plunger cover of FIG. 3A .
- FIG. 3F illustrates a front perspective view of the central or cone portion of the plunger of FIG. 3A .
- FIG. 4A illustrates a perspective view of another embodiment of a plunger of the present invention.
- FIG. 4B illustrates a perspective cutaway view of the plunger of FIG. 4A .
- FIG. 4C illustrates a front perspective, exploded view of the plunger of FIG. 4A wherein the plunger cover is disconnected from the base and the sealing portion of the plunger cover is separated from the central or cone portion of the plunger cover.
- FIG. 4D illustrates a rear perspective view of the plunger cover of the plunger FIG. 4A .
- FIG. 4E illustrates a front, cutaway perspective view of the plunger cover of the plunger of FIG. 4A .
- FIG. 4F illustrates a rear perspective, exploded view of the plunger cover of the plunger of FIG. 4A wherein the sealing portion of the plunger cover is separated from the central or cone portion of the plunger cover.
- FIG. 4G illustrates a front perspective, exploded view of the plunger cover of the plunger of FIG. 4A wherein the sealing portion of the plunger cover is separated from the central or cone portion of the plunger cover.
- FIG. 5A illustrates a front perspective view of another embodiment of a plunger of the present invention.
- FIG. 5B illustrates a perspective, cutaway view of the plunger of FIG. 5A .
- FIG. 5C illustrates a rear perspective view of the plunger of FIG. 5A .
- FIG. 5D illustrates a front perspective, exploded view of the plunger of FIG. 5A .
- FIG. 5E illustrates a front perspective, exploded view of the plunger of FIG. 5A .
- plunger 10 includes a plunger cover 20 that contacts the fluid within a syringe 100 (see FIG. 1F ) and forms a seal with the inner wall of the generally cylindrical barrel of syringe 100 .
- Syringe 100 is adapted to be removably connected to an injector 200 via, for example, a retaining flange 110 on syringe 100 the cooperates with a retainer on a syringe interface 210 of injector 200 .
- Injector 200 includes a drive member or piston 220 moveable in a reciprocal manner to pressurize fluid within syringe 100 .
- Plunger cover 20 includes a sealing section 30 formed, for example, from an elastomeric material suitable to form a sealing engagement with the inner wall of syringe 100 .
- Plunger cover 20 further includes a generally central portion 40 formed from a generally rigid polymeric material.
- central portion 40 has a conical shape adapted to contact the injection fluid and to mate generally with a conical transition region 120 of syringe 100 .
- Plunger 10 further includes a base, support or support ring 50 to which plunger cover 20 is attached.
- elastomeric sealing portion 30 includes a radially inward projecting flange 32 that is seatable within a seating 52 formed in base 50 .
- Base 50 further includes a forward surface 54 that is shaped to contact and mate generally with a rearward surface of plunger cover 20 and to provide support for plunger cover 20 .
- abutment of forward surface 54 with plunger cover 20 limits or prevents rearward motion of plunger cover 20 relative to base or support 50 .
- forward surface 54 preferably contacts a portion of plunger cover 20 so that at least a portion of rigid central conical portion is in alignment with at least a portion forward surface 54 .
- a rearward surface 56 of base 50 is adapted to be contacted by piston 220 .
- plunger cover 20 is formed in an overmolding process such as disclosed in WO 2004/035289.
- an injection molding machine is used which includes a heated screw and barrel that melt polymer to a liquid state.
- an injection molding machine pushes/injects the molten polymer through a heated manifold system into a mold. Once the polymer is inside the mold, it is cooled to a final shape (as determined by the internal dimensions of the mold), and then ejected.
- waste material associated with injection molding overmolding processes is less than associated with many other manufacturing processes for multi-component articles.
- the overmolding process can be operated automatically. Once the part is formed and cooled, no additional operations are required.
- sealing portion 30 of plunger cover 20 is first injection molded in an appropriately shaped mold.
- materials suitable for use in injection molding sealing portion 30 include thermoplastic elastomers (TPE) or thermoplastic polyurethanes (TPU).
- TPE thermoplastic elastomers
- TPU thermoplastic polyurethanes
- a thermoplastic elastomer or thermoplastic rubber (TPR) is a polymer compound or blend which exhibits a thermoplastic character above its melt temperature that enables it to be shaped into a fabricated article. Within the design temperature range, the material exhibits elastomeric behavior.
- sealing portion 30 was fabricated from SANTOPRENE®, a TPE available, for example, from Advanced Elastomer Systems, L.P. of Akron, Ohio.
- central portion 40 of plunger cover 20 was molded over the TPE/TPU material of molded sealing portion 30 .
- Central portion 40 was injection overmolded with a rigid polymeric material (for example, polypropylene, acrylonitrile butadiene styrene (ABS) or polycarbonate (PC)).
- ABS acrylonitrile butadiene styrene
- PC polycarbonate
- Copolymers such as, for example, a PC/ABS copolymer are also suitable for use herein.
- the overmolding process for example, can be done in a manual transferred operation or automatically within the same molding machine. In an insert molding process, for example, sealing portion 30 is molded first. Sealing portion 30 is then inserted into another process/mold and is overmolded over with another polymer.
- the overmolded polymer does not have to be rigid polymer.
- the overmolded polymer can, for example, be another polymer having different physiochemical properties.
- a multilayered plunger/plunger cover can thereby be formed. For example, a less expensive material can be used on an inner portion of the plunger/plunger cover and a more expensive material (having better functionality—for example, a medical grade material) can be used on the outside of the plunger/plunger cover.
- a molecular bond can be formed between the material of sealing portion 30 and central portion 40 .
- sealing portion 30 can be overmolded upon central portion 40 .
- Control of the strength of the molecular bond can be achieved by appropriate selection of materials.
- the melt temperature of the first injected material is preferably similar to the melt temperature of the second, overmolded material. Materials that have dissimilar melt temperatures typically result in a weak molecular bond.
- sealing portion 30 and central portion 40 can be shaped to interconnect mechanically to add structural integrity to the connection therebetween.
- elastomeric sealing portion 30 can be formed with a seating or groove 34 into which an extending portion 42 of central conical section 40 (see, for example, FIG. 1C ) extends during the overmolding process to provide mechanical interconnection and structural integrity to the connection between sealing portion 30 and central portion 40 .
- elastomeric sealing portion 30 mates and form a sealing engagement with the syringe barrel wall to seal fluid inside syringe 100 .
- central conical portion 40 formed from a relatively rigid polymeric material, provides additional structural integrity. The increased structural integrity also reduces compliance.
- Overmolded plunger cover 20 is a separate component of the plunger and can be assembled in various configurations (for example, with different bases or supports or without a base or support). The design and manufacturing methods associated with plunger 10 reduce manufacturing costs, while maintaining functionality. The manufacturing process provides the capability of customization of plunger cover 20 . For example, colorants can be applied to the rigid polymer cone for various purposes.
- the overall shape of the plunger cover can readily be altered for use with different syringes.
- the forward portion of the plunger cover can have a conical, hemispherical, flat or other shape to mate with a correspondingly shaped syringe.
- plunger 10 can replace currently available compression molded plunger covers in currently available plunger designs while maintaining or improving functionality of those plunger designs.
- FIGS. 2A through 2E illustrate another embodiment of a plunger 310 of the present invention which is similar in design, operation and manufacture to plunger 10 .
- base or support 50 is identical to that used in plunger 10 .
- Plunger cover 320 differs from plunger cover 20 , for example, in the form of the mechanical interconnection between sealing portion 330 and central portion 340 , which in the embodiment of FIGS. 2A through 2E is generally conical in shape.
- elastomeric sealing portion 330 is formed with a seating or groove 334 that is somewhat shorter in length than seating 34 of sealing portion 30 .
- central portion 340 includes an extending portion 342 which extends into seating 334 during the overmolding process.
- forward surface 54 of base 50 contacts a rearward surface of central conical portion 340 directly (without any section of sealing portion 330 therebetween).
- FIGS. 3A through 3F illustrate another embodiment of a plunger 410 of the present invention.
- plunger 410 includes a plunger cover 420 , which includes a sealing section 430 formed, for example, from an elastomeric material such as a TPE/TPU material.
- Plunger cover 420 further includes a generally conical central portion 440 formed from a generally rigid polymeric material, preferably in an overmolding process.
- Plunger 410 further includes base or support ring 50 as described above to which plunger cover 420 is attached.
- elastomeric sealing portion 430 includes a radially inward projecting flange 432 that is seatable within seating 52 formed in base 50 .
- plunger cover 420 is readily adjusted in shape and dimension to mate with a desired support.
- Central portion 440 can include extending tabs 442 which can assist in forming a secure interconnection between central portion 440 and sealing portion 430 .
- sealing portion 430 includes a generally conical central section 436 appropriately dimensioned such that the forward surface of central section 436 of sealing portion 430 mates with the rearward surface of rigid conical central portion 440 .
- Central section 436 of sealing portion 430 can, for example, provide greater area for molecular bonding between central portion 440 and sealing portion 430 during the overmolding process.
- Central section 436 of sealing portion 430 can also provide for more effective molding of plunger cover 420 in that injection gates for sealing portion 430 and central portion 440 can have the same general location.
- FIGS. 4A through 4G illustrate another embodiment of a plunger 510 of the present invention.
- plunger 510 includes a plunger cover 520 , which includes a sealing portion 530 formed, for example, from an elastomeric material such as a TPE/TPU material.
- Plunger cover 520 further includes a generally conical central portion 540 formed from a generally rigid polymeric material, preferably in an overmolding process.
- Plunger 510 further includes base or support ring 50 as described above to which plunger cover 520 is attached.
- elastomeric sealing portion 530 includes a radially inward projecting flange 532 that is seatable within seating 52 formed in base 50 .
- plunger cover 520 is readily adjusted in shape and dimension to mate with a desired support.
- central portion 540 is positioned to the rear of a generally conical central section 536 of sealing portion 430 .
- rigid central portion 540 does not contact the injection fluid, but still provides structural integrity to plunger cover 520 .
- FIGS. 5A through 5E illustrate another embodiment of a plunger 610 of the present invention.
- plunger 610 does not include a plunger base or support as, for example, described in connection with base or support ring 50 .
- a sealing portion 630 (formed or molded from and elastomeric material such as a TPE/TPU material) includes a seating 638 (for example, a threaded seating) to form a connection (for example, a removable connection) with a drive member.
- a rigid central portion 640 can, for example, be connected with sealing portion 630 in an overmolding process as described above.
Abstract
A plunger cover for use with a syringe includes a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe. The central portion can, for example, be more rigid than the sealing portion. The sealing portion and the central portion are connected in an overmolding process. The sealing portion can, for example, be formed from a thermoplastic elastomer or a thermoplastic polyurethane. The central portion can, for example, be formed from polypropylene, acrylonitrile butadiene styrene, polycarbonate or copolymers thereof.
Description
- This application is a Continuation of U.S. application Ser. No. 15/851,860, filed Dec. 22, 2017, which is a Continuation of U.S. application Ser. No. 14/576,354, filed Dec. 19, 2014, now U.S. Pat. No. 9,855,390, which is a Division of U.S. application Ser. No. 11/686,000, filed Mar. 14, 2007, now U.S. Pat. No. 8,926,569, which claims benefit from the earlier filed U.S. Provisional Application Ser. No. 60/782,623, filed on Mar. 15, 2006, entitled “Plunger covers and plungers for use in syringes and methods of fabricating plunger covers and plungers for use in syringes,” and is hereby incorporated into this application by reference as if fully set forth herein.
- The present invention relates generally to plunger covers and to plungers for use in syringes and to methods of fabrication of plunger covers and plungers for use in syringes, and particularly, to plunger covers and to plungers for use in syringes to inject fluids into a patient and to methods of fabrication thereof.
- A number of injector-actuated syringes and powered injectors for use in medical procedures such as angiography, computed tomography, ultrasound and magnetic resonance imaging (MRI) have been developed. U.S. Pat. No. 4,006,736, the disclosure of which is incorporated herein by reference, for example, discloses an injector and syringe for injecting fluid into the vascular system of a human being or an animal. Typically, such injectors comprise drive members such as pistons that operatively connect to a syringe plunger. For example, U.S. Pat. No. 4,677,980, the disclosure of which is incorporated herein by reference, discloses an angiographic injector and syringe wherein the drive member of the injector can be connected to, or disconnected from, the syringe plunger at any point along the travel path of the plunger via a releasable mechanism. A front-loading syringe and injector system is also disclosed in U.S. Pat. No. 5,383,858, the disclosure of which is incorporated herein by reference. Front-loading syringes and syringe plungers for use therewith are also disclosed in U.S. Pat. Nos. 6,585,700 and 6,224,577, the disclosures of which are incorporated herein by reference.
- Forward, sliding motion of the syringe plunger within the syringe barrel pressurizes the fluid within the syringe, and the pressurized fluid is injected into that patient via a syringe outlet. A common method of manufacturing syringe plungers adapted, for example, for use in connection with powered injectors is to place an elastomeric, sealing plunger cover over a rigid base. Such rubber covers can, for example, be manufactured by a vulcanization compression molding process. The rubber covers can, for example, be molded into a sheet and then manually hand cut (through a cutting die) from the sheet. Once cut, the rubber covers are, for example, washed in a silicone wash and then assembled onto a plunger base for insertion into a syringe. The process results in substantial material waste and can also result in substantial manufacturing costs and time.
- U.S. Pat. No. 5,902,276, the disclosure of which in incorporated herein by reference, discloses a syringe plunger that is formed by a two-shot molding process. A hard plastic core is first formed in a first mold. Subsequently, the distal portion of the hard plastic core is overmolded with a soft rubber plunger cover in a second mold. The second overmolding can occur in the second mold while the core is still cooling to effect molecular bonding of the rubber of the cover with the as-yet uncured plastic of the core.
- WO 2004/035289, the disclosure of which is incorporated herein by reference, a copy of which is included herewith and made a part hereof, discloses a method of manufacturing plungers for medical syringes wherein the plunger includes at least two parts. In that regard, the plunger includes a plunger body made of a first plastic and a piston body (in the form of a sealing cover) at the front of the plunger body made of a second plastic. The second plastic (an elastomer) is softer than the first plastic (a generally rigid plastic) of the plunger cover. In forming the plunger, the piston body is first formed by injection molding. Then, the plunger body (or a part thereof) is injected molded against or over the piston body.
- Although a number of syringe plungers and methods of fabrication or manufacture of syringe plungers have been developed, it is desirable to develop improved syringe plungers and methods of fabrication of syringe plungers.
- In one aspect, the present invention provides a plunger cover for use with a syringe including a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe. The central portion can, for example, be more rigid than the sealing portion. The sealing portion and the central portion are connected in an overmolding process. The sealing portion can, for example, be formed from a thermoplastic elastomer or a thermoplastic polyurethane. The central portion can, for example, be formed from polypropylene, acrylonitrile butadiene styrene, polycarbonate or copolymers thereof.
- In several embodiments, the sealing portion is injection molded first and the central portion is injection overmolded thereon. In other embodiments, the central portion is injection molded first and the sealing portion is injection overmolded thereon. In several preferred embodiments, the sealing portion is injection molded first and the central portion is injection overmolded thereon. The material for the sealing portion and the material for the central portion can be selected so that molecular bonding occurs between the sealing portion and the central portion.
- In another aspect, the present provides a plunger for use with a syringe including a plunger cover including a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe as described above. The central portion can, for example, be more rigid than the sealing portion. The sealing portion and the central portion are connected in an overmolding process. The plunger further includes a support attached to the plunger cover.
- The sealing portion can, for example, includes a radially inward projecting flange that is seated within a seating formed on the support to connect the plunger cover to the support. The support can, for example, include a forward surface adapted to abut the plunger cover to prevent rearward motion of the central portion relative to the support.
- In another aspect, the present invention provides a syringe including a syringe body and a plunger slidably positioned within the syringe body. As described above, the plunger includes a plunger cover including a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe. The central portion can, for example, be more rigid than the sealing portion. The sealing portion and the central portion are connected in an overmolding process. The plunger further includes a support attached to the plunger cover.
- In a further aspect, the present invention provides a method of fabricating a plunger cover for use in a syringe, including: connecting a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe in an overmolding process, the central portion being more rigid than the sealing portion. The sealing portion can, for example, be injection molded first and the central portion is injection overmolded thereon. Alternatively, the central portion can be injection molded first and the sealing portion is injection overmolded thereon.
- In another aspect, the present invention provides a plunger cover for use with a syringe including a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe. The central portion has at least one physiochemical property that differs from the sealing portion. The sealing portion and the central portion are connected in an overmolding process.
- In another aspect, the present invention provides a plunger cover for use with a syringe including a sealing portion adapted to form a seal with the syringe and a central portion. The central portion is more rigid than the sealing portion. The sealing portion and the central portion being connected in an overmolding process. In one embodiment, the central portion is positioned forward of at least a portion of the sealing portion and is adapted to contact fluid within the syringe. In another embodiment, the central portion is positioned rearward of a generally central section of the sealing portion and does not contact fluid within the syringe. The central portion can, for example, be overmolded upon the sealing portion. Alternatively, the central portion can be injection molded first and the sealing portion is injection overmolded thereon.
- In still a further aspect, the present invention provides a plunger for use with a syringe including a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe. The central portion is, for example, more rigid than the sealing portion. The sealing portion and the central portion are connected in an overmolding process. The sealing portion can, for example, be adapted to form an operative connection with a drive member.
- The present invention, along with the attributes and attendant advantages thereof, will best be appreciated and understood in view of the following detailed description taken in conjunction with the accompanying drawings.
-
FIG. 1A illustrates a perspective view of an embodiment of a plunger of the present invention. -
FIG. 1B illustrates a perspective cutaway view of the plunger ofFIG. 1A . -
FIG. 1C illustrates an enlarged cutaway view of a portion of the plunger ofFIG. 1A . -
FIG. 1D illustrates a rear perspective, exploded view of the plunger ofFIG. 1A wherein the plunger cover is disconnected from the base. -
FIG. 1E illustrates a front perspective, exploded view of the plunger ofFIG. 1A wherein the plunger cover is disconnected from the base. -
FIG. 1F illustrates a side schematic view of the plunger ofFIG. 1A slidably positioned within a syringe that is removably attached to a powered injector. -
FIG. 2A illustrates a perspective view of another embodiment of a plunger of the present invention. -
FIG. 2B illustrates a perspective cutaway view of the plunger ofFIG. 2A . -
FIG. 2C illustrates an enlarged perspective cutaway view of a portion of the plunger ofFIG. 2A . -
FIG. 2D illustrates a rear perspective, exploded view of the plunger ofFIG. 2A wherein the plunger cover is disconnected from the base. -
FIG. 2E illustrates a front perspective, exploded view of the plunger ofFIG. 2A wherein the plunger cover is disconnected from the base. -
FIG. 3A illustrates a perspective view of another embodiment of a plunger of the present invention. -
FIG. 3B illustrates a perspective cutaway view of the plunger ofFIG. 3A . -
FIG. 3C illustrates a front perspective, exploded view of the plunger ofFIG. 3A wherein the plunger cover is disconnected from the base and the sealing portion of the plunger cover is separated from the central or cone portion of the plunger cover. -
FIG. 3D illustrates a rear perspective, exploded view of the plunger ofFIG. 3A wherein the plunger cover is disconnected from the base and the sealing portion of the plunger cover is separated from the central or cone portion of the plunger cover. -
FIG. 3E illustrates a front perspective view of the sealing portion of the plunger cover ofFIG. 3A . -
FIG. 3F illustrates a front perspective view of the central or cone portion of the plunger ofFIG. 3A . -
FIG. 4A illustrates a perspective view of another embodiment of a plunger of the present invention. -
FIG. 4B illustrates a perspective cutaway view of the plunger ofFIG. 4A . -
FIG. 4C illustrates a front perspective, exploded view of the plunger ofFIG. 4A wherein the plunger cover is disconnected from the base and the sealing portion of the plunger cover is separated from the central or cone portion of the plunger cover. -
FIG. 4D illustrates a rear perspective view of the plunger cover of the plungerFIG. 4A . -
FIG. 4E illustrates a front, cutaway perspective view of the plunger cover of the plunger ofFIG. 4A . -
FIG. 4F illustrates a rear perspective, exploded view of the plunger cover of the plunger ofFIG. 4A wherein the sealing portion of the plunger cover is separated from the central or cone portion of the plunger cover. -
FIG. 4G illustrates a front perspective, exploded view of the plunger cover of the plunger ofFIG. 4A wherein the sealing portion of the plunger cover is separated from the central or cone portion of the plunger cover. -
FIG. 5A illustrates a front perspective view of another embodiment of a plunger of the present invention. -
FIG. 5B illustrates a perspective, cutaway view of the plunger ofFIG. 5A . -
FIG. 5C illustrates a rear perspective view of the plunger ofFIG. 5A . -
FIG. 5D illustrates a front perspective, exploded view of the plunger ofFIG. 5A . -
FIG. 5E illustrates a front perspective, exploded view of the plunger ofFIG. 5A . - One embodiment of a
plunger 10 of the present invention is illustrated inFIGS. 1A through 1F . As illustrated, for example, inFIGS. 1D and 1E ,plunger 10 includes aplunger cover 20 that contacts the fluid within a syringe 100 (seeFIG. 1F ) and forms a seal with the inner wall of the generally cylindrical barrel ofsyringe 100.Syringe 100 is adapted to be removably connected to aninjector 200 via, for example, a retainingflange 110 onsyringe 100 the cooperates with a retainer on asyringe interface 210 ofinjector 200.Injector 200 includes a drive member orpiston 220 moveable in a reciprocal manner to pressurize fluid withinsyringe 100. -
Plunger cover 20 includes asealing section 30 formed, for example, from an elastomeric material suitable to form a sealing engagement with the inner wall ofsyringe 100.Plunger cover 20 further includes a generallycentral portion 40 formed from a generally rigid polymeric material. In the embodiment ofFIGS. 1A through 1G ,central portion 40 has a conical shape adapted to contact the injection fluid and to mate generally with aconical transition region 120 ofsyringe 100.Plunger 10 further includes a base, support orsupport ring 50 to which plunger cover 20 is attached. In that regard, elastomeric sealingportion 30 includes a radially inward projectingflange 32 that is seatable within aseating 52 formed inbase 50.Base 50 further includes aforward surface 54 that is shaped to contact and mate generally with a rearward surface ofplunger cover 20 and to provide support forplunger cover 20. In that regard, abutment offorward surface 54 withplunger cover 20 limits or prevents rearward motion ofplunger cover 20 relative to base orsupport 50. To limit such rearward motion, forward surface 54 preferably contacts a portion ofplunger cover 20 so that at least a portion of rigid central conical portion is in alignment with at least a portion forward surface 54. Arearward surface 56 ofbase 50 is adapted to be contacted bypiston 220. - Preferably,
plunger cover 20 is formed in an overmolding process such as disclosed in WO 2004/035289. In an injection overmolding process, an injection molding machine is used which includes a heated screw and barrel that melt polymer to a liquid state. In general, an injection molding machine pushes/injects the molten polymer through a heated manifold system into a mold. Once the polymer is inside the mold, it is cooled to a final shape (as determined by the internal dimensions of the mold), and then ejected. In general, waste material associated with injection molding overmolding processes is less than associated with many other manufacturing processes for multi-component articles. Moreover, the overmolding process can be operated automatically. Once the part is formed and cooled, no additional operations are required. - In one embodiment of an overmolding process of the present invention, sealing
portion 30 ofplunger cover 20 is first injection molded in an appropriately shaped mold. Examples of materials suitable for use in injectionmolding sealing portion 30 include thermoplastic elastomers (TPE) or thermoplastic polyurethanes (TPU). In general, a thermoplastic elastomer or thermoplastic rubber (TPR) is a polymer compound or blend which exhibits a thermoplastic character above its melt temperature that enables it to be shaped into a fabricated article. Within the design temperature range, the material exhibits elastomeric behavior. In one embodiment, sealingportion 30 was fabricated from SANTOPRENE®, a TPE available, for example, from Advanced Elastomer Systems, L.P. of Akron, Ohio. After injection molding of sealingportion 30,central portion 40 ofplunger cover 20 was molded over the TPE/TPU material of molded sealingportion 30.Central portion 40 was injection overmolded with a rigid polymeric material (for example, polypropylene, acrylonitrile butadiene styrene (ABS) or polycarbonate (PC)). Copolymers such as, for example, a PC/ABS copolymer are also suitable for use herein. The overmolding process, for example, can be done in a manual transferred operation or automatically within the same molding machine. In an insert molding process, for example, sealingportion 30 is molded first. Sealingportion 30 is then inserted into another process/mold and is overmolded over with another polymer. - The overmolded polymer does not have to be rigid polymer. The overmolded polymer can, for example, be another polymer having different physiochemical properties. A multilayered plunger/plunger cover can thereby be formed. For example, a less expensive material can be used on an inner portion of the plunger/plunger cover and a more expensive material (having better functionality—for example, a medical grade material) can be used on the outside of the plunger/plunger cover.
- As known in the overmolding arts, a molecular bond can be formed between the material of sealing
portion 30 andcentral portion 40. In addition to overmoldingcentral portion 40 upon sealingportion 30, sealingportion 30 can be overmolded uponcentral portion 40. Control of the strength of the molecular bond can be achieved by appropriate selection of materials. In that regard, as known in the injection molding arts, to form a stronger molecular bond, the melt temperature of the first injected material is preferably similar to the melt temperature of the second, overmolded material. Materials that have dissimilar melt temperatures typically result in a weak molecular bond. - In addition to molecular bonding, sealing
portion 30 andcentral portion 40 can be shaped to interconnect mechanically to add structural integrity to the connection therebetween. For example, elastomeric sealingportion 30 can be formed with a seating or groove 34 into which an extendingportion 42 of central conical section 40 (see, for example,FIG. 1C ) extends during the overmolding process to provide mechanical interconnection and structural integrity to the connection between sealingportion 30 andcentral portion 40. - As described above,
elastomeric sealing portion 30 mates and form a sealing engagement with the syringe barrel wall to seal fluid insidesyringe 100. As compared to plunger covers formed generally entirely of an elastomeric material via, for example, a compression molding process, centralconical portion 40, formed from a relatively rigid polymeric material, provides additional structural integrity. The increased structural integrity also reduces compliance.Overmolded plunger cover 20 is a separate component of the plunger and can be assembled in various configurations (for example, with different bases or supports or without a base or support). The design and manufacturing methods associated withplunger 10 reduce manufacturing costs, while maintaining functionality. The manufacturing process provides the capability of customization ofplunger cover 20. For example, colorants can be applied to the rigid polymer cone for various purposes. Moreover, the overall shape of the plunger cover can readily be altered for use with different syringes. For example, the forward portion of the plunger cover can have a conical, hemispherical, flat or other shape to mate with a correspondingly shaped syringe. In general,plunger 10 can replace currently available compression molded plunger covers in currently available plunger designs while maintaining or improving functionality of those plunger designs. -
FIGS. 2A through 2E illustrate another embodiment of aplunger 310 of the present invention which is similar in design, operation and manufacture toplunger 10. Inplunger 310, base orsupport 50 is identical to that used inplunger 10.Plunger cover 320 differs fromplunger cover 20, for example, in the form of the mechanical interconnection between sealingportion 330 andcentral portion 340, which in the embodiment ofFIGS. 2A through 2E is generally conical in shape. In that regard, For example,elastomeric sealing portion 330 is formed with a seating or groove 334 that is somewhat shorter in length than seating 34 of sealingportion 30. Similar tocentral portion 40,central portion 340 includes an extendingportion 342 which extends intoseating 334 during the overmolding process. In the embodiment ofFIGS. 2A through 2E , forward surface 54 ofbase 50 contacts a rearward surface of centralconical portion 340 directly (without any section of sealingportion 330 therebetween). -
FIGS. 3A through 3F illustrate another embodiment of aplunger 410 of the present invention. Similar toplungers plunger 410 includes aplunger cover 420, which includes asealing section 430 formed, for example, from an elastomeric material such as a TPE/TPU material.Plunger cover 420 further includes a generally conicalcentral portion 440 formed from a generally rigid polymeric material, preferably in an overmolding process.Plunger 410 further includes base orsupport ring 50 as described above to whichplunger cover 420 is attached. In that regard,elastomeric sealing portion 430 includes a radially inward projectingflange 432 that is seatable withinseating 52 formed inbase 50. As with other embodiments of the present invention, however,plunger cover 420 is readily adjusted in shape and dimension to mate with a desired support. -
Central portion 440 can include extendingtabs 442 which can assist in forming a secure interconnection betweencentral portion 440 and sealingportion 430. In general, such mechanical interconnections are optional in all overmolding embodiments of the present invention. In the embodiment ofFIGS. 3A through 3F sealing portion 430 includes a generally conicalcentral section 436 appropriately dimensioned such that the forward surface ofcentral section 436 of sealingportion 430 mates with the rearward surface of rigid conicalcentral portion 440.Central section 436 of sealingportion 430 can, for example, provide greater area for molecular bonding betweencentral portion 440 and sealingportion 430 during the overmolding process.Central section 436 of sealingportion 430 can also provide for more effective molding ofplunger cover 420 in that injection gates for sealingportion 430 andcentral portion 440 can have the same general location. -
FIGS. 4A through 4G illustrate another embodiment of aplunger 510 of the present invention. Similar toplunger 410,plunger 510 includes aplunger cover 520, which includes a sealingportion 530 formed, for example, from an elastomeric material such as a TPE/TPU material.Plunger cover 520 further includes a generally conicalcentral portion 540 formed from a generally rigid polymeric material, preferably in an overmolding process.Plunger 510 further includes base orsupport ring 50 as described above to whichplunger cover 520 is attached. In that regard,elastomeric sealing portion 530 includes a radially inward projectingflange 532 that is seatable withinseating 52 formed inbase 50. As with other embodiments of the present invention, however,plunger cover 520 is readily adjusted in shape and dimension to mate with a desired support. - In the embodiment of
FIGS. 4A through 4G central portion 540 is positioned to the rear of a generally conicalcentral section 536 of sealingportion 430. In this embodiment, rigidcentral portion 540 does not contact the injection fluid, but still provides structural integrity toplunger cover 520. -
FIGS. 5A through 5E illustrate another embodiment of aplunger 610 of the present invention. Unlike the plunger embodiments set forth above,plunger 610 does not include a plunger base or support as, for example, described in connection with base orsupport ring 50. In that regard, a sealing portion 630 (formed or molded from and elastomeric material such as a TPE/TPU material) includes a seating 638 (for example, a threaded seating) to form a connection (for example, a removable connection) with a drive member. A rigidcentral portion 640 can, for example, be connected with sealingportion 630 in an overmolding process as described above. - The foregoing description and accompanying drawings set forth the preferred embodiments of the invention at the present time. Various modifications, additions and alternative designs will, of course, become apparent to those skilled in the art in light of the foregoing teachings without departing from the scope of the invention. The scope of the invention is indicated by the following claims rather than by the foregoing description. All changes and variations that fall within the meaning and range of equivalency of the claims are to be embraced within their scope.
Claims (19)
1.-17. (canceled)
18. A plunger cover for use with a syringe, the plunger cover comprising:
a sealing portion having an outer sealing section and a central section; and
a central portion,
wherein the sealing portion is made from a first material and the central portion is made from a second material different than the first material, the first material being less rigid than the second material, and
wherein the sealing portion and the central portion are overmolded such that the central section of the sealing portion and the central portion are coextensively connected to form a multilayer portion of the plunger cover.
19. The plunger cover of claim 18 , wherein the first material is a thermoplastic elastomer or a thermoplastic polyurethane.
20. The plunger cover of claim 18 , wherein the second material is polypropylene, acrylonitrile butadiene styrene, or polycarbonate.
21. The plunger cover of claim 18 , wherein the first material and the second material are selected so that molecular bonding occurs between the sealing portion and the central portion.
22. The plunger cover of claim 18 , wherein the sealing portion and the central portion are shaped to interconnect mechanically.
23. The plunger cover of claim 18 , wherein the plunger cover contains colorant.
24. The plunger cover of claim 18 , wherein the sealing portion comprises an inwardly projecting flange configured for being seated in a seating formed in a support ring.
25. The plunger cover of claim 18 , wherein the central portion contains colorant.
26. A plunger for use with a syringe, the plunger comprising:
a rigid support ring; and
a plunger cover connected to the rigid support ring, the plunger cover comprising:
a sealing portion made from a first material; and
a central portion made from a second material different from the first material,
wherein the first material is less rigid than the second material, and
wherein the sealing portion and the central portion are overmolded such that the sealing portion and the central portion are coextensively connected to form a multilayer portion of the plunger cover.
27. The plunger of claim 26 , wherein the first material is a thermoplastic elastomer or a thermoplastic polyurethane.
28. The plunger of claim 26 , wherein the second material is polypropylene, acrylonitrile butadiene styrene, or polycarbonate.
29. The plunger of claim 26 , wherein the first material and the second material are selected so that molecular bonding occurs between the sealing portion and the central portion.
30. The plunger of claim 26 , wherein the sealing portion and the central portion are shaped to interconnect mechanically.
31. The plunger of claim 26 , wherein the plunger cover contains colorant.
32. The plunger of claim 26 , wherein the sealing portion includes a radially inward projecting flange that is seated within a seating formed on the support ring to connect the plunger cover to the support ring.
33. The plunger of claim 26 , wherein a forward surface of the support ring abuts the plunger cover to prevent rearward motion of the central portion of the plunger cover relative to the support ring.
34. The plunger of claim 26 , wherein the central portion contains colorant.
35. A syringe comprising:
a syringe body and a plunger slidably positioned within the syringe body, the plunger comprising:
a rigid support ring; and
a plunger cover connected to the rigid support ring, the plunger cover comprising:
a sealing portion made from a first material; and
a central portion made from a second material different from the first material,
wherein the first material is less rigid than the second material, and
wherein the sealing portion and the central portion are overmolded such that the sealing portion and the central portion are coextensively connected to form a multilayer portion of the plunger cover.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/946,008 US20200289765A1 (en) | 2006-03-15 | 2020-06-02 | Plunger covers and plungers for use in syringes |
US29/751,090 USD1002840S1 (en) | 2007-03-14 | 2020-09-18 | Syringe plunger |
US18/052,050 US20230166042A1 (en) | 2006-03-15 | 2022-11-02 | Plunger covers and plungers for use in syringes |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78262306P | 2006-03-15 | 2006-03-15 | |
US11/686,000 US8926569B2 (en) | 2006-03-15 | 2007-03-14 | Plunger covers and plungers for use in syringes and methods of fabricating plunger covers and plungers for use in syringes |
US14/576,354 US9855390B2 (en) | 2006-03-15 | 2014-12-19 | Plunger covers and plungers for use in syringes |
US15/851,860 US10668221B2 (en) | 2006-03-15 | 2017-12-22 | Plunger covers and plungers for use in syringes |
US16/946,008 US20200289765A1 (en) | 2006-03-15 | 2020-06-02 | Plunger covers and plungers for use in syringes |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/851,860 Continuation US10668221B2 (en) | 2006-03-15 | 2017-12-22 | Plunger covers and plungers for use in syringes |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US29/751,090 Continuation USD1002840S1 (en) | 2007-03-14 | 2020-09-18 | Syringe plunger |
US18/052,050 Continuation US20230166042A1 (en) | 2006-03-15 | 2022-11-02 | Plunger covers and plungers for use in syringes |
Publications (1)
Publication Number | Publication Date |
---|---|
US20200289765A1 true US20200289765A1 (en) | 2020-09-17 |
Family
ID=38518868
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/686,000 Active 2029-02-01 US8926569B2 (en) | 2006-03-15 | 2007-03-14 | Plunger covers and plungers for use in syringes and methods of fabricating plunger covers and plungers for use in syringes |
US14/576,354 Active 2027-06-14 US9855390B2 (en) | 2006-03-15 | 2014-12-19 | Plunger covers and plungers for use in syringes |
US15/851,860 Active 2027-08-28 US10668221B2 (en) | 2006-03-15 | 2017-12-22 | Plunger covers and plungers for use in syringes |
US16/946,008 Abandoned US20200289765A1 (en) | 2006-03-15 | 2020-06-02 | Plunger covers and plungers for use in syringes |
US18/052,050 Pending US20230166042A1 (en) | 2006-03-15 | 2022-11-02 | Plunger covers and plungers for use in syringes |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/686,000 Active 2029-02-01 US8926569B2 (en) | 2006-03-15 | 2007-03-14 | Plunger covers and plungers for use in syringes and methods of fabricating plunger covers and plungers for use in syringes |
US14/576,354 Active 2027-06-14 US9855390B2 (en) | 2006-03-15 | 2014-12-19 | Plunger covers and plungers for use in syringes |
US15/851,860 Active 2027-08-28 US10668221B2 (en) | 2006-03-15 | 2017-12-22 | Plunger covers and plungers for use in syringes |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US18/052,050 Pending US20230166042A1 (en) | 2006-03-15 | 2022-11-02 | Plunger covers and plungers for use in syringes |
Country Status (1)
Country | Link |
---|---|
US (5) | US8926569B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11883636B2 (en) | 2018-02-27 | 2024-01-30 | Bayer Healthcare Llc | Syringe plunger engagement mechanism |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7666169B2 (en) | 2003-11-25 | 2010-02-23 | Medrad, Inc. | Syringe and syringe plungers for use with medical injectors |
EP1917991B1 (en) * | 2005-08-01 | 2013-11-20 | Nipro Corporation | Plunger for injector, and syringe and prefilled syringe that use the same |
US8091864B2 (en) | 2005-12-20 | 2012-01-10 | Ds Smith Plastics Limited | Valve for a fluid flow connector having an overmolded plunger |
US8926569B2 (en) * | 2006-03-15 | 2015-01-06 | Bayer Medical Care Inc. | Plunger covers and plungers for use in syringes and methods of fabricating plunger covers and plungers for use in syringes |
USD942005S1 (en) * | 2007-03-14 | 2022-01-25 | Bayer Healthcare Llc | Orange syringe plunger cover |
USD847985S1 (en) * | 2007-03-14 | 2019-05-07 | Bayer Healthcare Llc | Syringe plunger cover |
CN101066483A (en) * | 2007-06-11 | 2007-11-07 | 东莞捷讯橡胶有限公司 | Syringe piston |
CN101801442A (en) * | 2007-09-21 | 2010-08-11 | 易麦克逊控股公司 | a releasable connecting mechanism |
CA2705772A1 (en) * | 2007-11-28 | 2009-06-04 | The Glad Products Company | Vacuum storage container |
EP2222570A4 (en) * | 2007-11-28 | 2011-12-14 | Glad Products Co | Storage container |
US9295776B2 (en) * | 2008-04-11 | 2016-03-29 | Medtronic Minimed, Inc. | Reservoir plunger head systems and methods |
US8858501B2 (en) * | 2008-04-11 | 2014-10-14 | Medtronic Minimed, Inc. | Reservoir barrier layer systems and methods |
US8206353B2 (en) * | 2008-04-11 | 2012-06-26 | Medtronic Minimed, Inc. | Reservoir barrier layer systems and methods |
US20100280370A1 (en) * | 2009-03-26 | 2010-11-04 | Namey Jr David | Syringe plunger |
JP5698223B2 (en) * | 2009-05-20 | 2015-04-08 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Plug for a drug-containing cartridge in a drug delivery device |
EP3189868A1 (en) | 2009-05-20 | 2017-07-12 | Sanofi-Aventis Deutschland GmbH | Bung for drug containing cartridges in drug delivery devices comprising an electronic coding feature |
US9340330B2 (en) | 2010-06-24 | 2016-05-17 | S. C. Johnson & Son, Inc. | Storage container lids |
CN103370617B (en) | 2010-10-01 | 2015-11-25 | 牛津纳米孔技术有限公司 | Biochemical analysis equipment and rotary valve |
ES2956238T3 (en) * | 2011-03-28 | 2023-12-15 | Becton Dickinson Co | Plastic lid |
GB2492955A (en) | 2011-07-13 | 2013-01-23 | Oxford Nanopore Tech Ltd | One way valve |
WO2013038164A2 (en) | 2011-09-15 | 2013-03-21 | Oxford Nanopore Technologies Limited | Piston seal |
GB2494683A (en) * | 2011-09-15 | 2013-03-20 | Oxford Nanopore Tech Ltd | A piston seal for a syringe or syringe pump |
WO2013057119A1 (en) * | 2011-10-19 | 2013-04-25 | Medtron Ag | Syringe for a high-pressure injector |
WO2013064590A1 (en) | 2011-11-02 | 2013-05-10 | Sanofi-Aventis Deutschland Gmbh | Piston for a cartridge for use in a drug delivery device |
WO2013148394A1 (en) * | 2012-03-27 | 2013-10-03 | Eli Lilly And Company | Plunger for a medication cartridge |
EP2659925A1 (en) * | 2012-05-02 | 2013-11-06 | Sanofi-Aventis Deutschland GmbH | Piston for a cartridge for use in a drug delivery device |
US9174003B2 (en) | 2012-09-28 | 2015-11-03 | Bayer Medical Care Inc. | Quick release plunger |
DE102012022359A1 (en) * | 2012-11-15 | 2014-05-15 | Vetter Pharma-Fertigung GmbH & Co. KG | Attachment for a syringe or carpule |
WO2014155607A1 (en) * | 2013-03-28 | 2014-10-02 | テルモ株式会社 | Syringe |
EP3119453B1 (en) | 2014-03-19 | 2019-02-27 | Bayer Healthcare LLC | System for syringe engagement to an injector |
US9199033B1 (en) | 2014-10-28 | 2015-12-01 | Bayer Healthcare Llc | Self-orienting syringe and syringe interface |
AU2015339382A1 (en) | 2014-10-28 | 2017-05-11 | Bayer Healthcare Llc | Self-orienting pressure jacket and pressure jacket-to-injector interface |
NO2689315T3 (en) | 2014-10-28 | 2018-04-14 | ||
KR102497204B1 (en) | 2014-10-28 | 2023-02-06 | 바이엘 헬쓰케어 엘엘씨 | Self-orienting pressure jacket and pressure jacket-to-injector interface |
FR3032122B1 (en) * | 2015-01-29 | 2020-02-21 | Aptar Stelmi Sas | PROCESS FOR PRODUCING A SYRINGE PISTON CAP. |
FR3032123B1 (en) * | 2015-01-29 | 2021-04-23 | Aptar Stelmi Sas | SYRINGE PLUG-PLUG. |
EP3791919A1 (en) | 2015-03-10 | 2021-03-17 | Regeneron Pharmaceuticals, Inc. | Aseptic piercing system |
HUE063561T2 (en) | 2015-08-28 | 2024-01-28 | Bayer Healthcare Llc | System and method for syringe fluid fill verification and image recognition of power injector system features |
US9480797B1 (en) * | 2015-10-28 | 2016-11-01 | Bayer Healthcare Llc | System and method for syringe plunger engagement with an injector |
US10835674B2 (en) * | 2015-11-13 | 2020-11-17 | Bayer Healthcare Llc | Nested syringe assembly |
US10737033B2 (en) | 2016-01-21 | 2020-08-11 | Merit Medical Systems, Inc. | Partially lubricated syringe barrels, plungers, and seal members and related methods |
EP3405238A4 (en) * | 2016-01-21 | 2019-09-25 | Merit Medical Systems, Inc. | Coverings for syringe plunger tips and methods related thereto |
EP4292627A3 (en) * | 2017-01-06 | 2024-03-20 | Bayer HealthCare LLC | Syringe plunger with dynamic seal |
CN106964030B (en) * | 2017-04-19 | 2023-04-11 | 深圳安科高技术股份有限公司 | Piston device for syringe |
IL269571B (en) | 2017-05-05 | 2022-08-01 | Regeneron Pharma | Auto-injector |
CN110831645B (en) * | 2017-08-09 | 2022-03-22 | 住友橡胶工业株式会社 | Gasket for syringe |
EP3659649B1 (en) * | 2017-08-09 | 2023-08-16 | Sumitomo Rubber Industries Ltd. | Syringe gasket |
EP3710100A4 (en) | 2017-11-13 | 2021-08-11 | Merit Medical Systems, Inc. | Staged deflation syringe systems and associated methods |
EP3501782A1 (en) * | 2017-12-20 | 2019-06-26 | Sulzer Mixpac AG | Method of making a two-component piston, injection mold for a two-component piston, two-component piston and cartridge |
US11191893B2 (en) | 2018-01-31 | 2021-12-07 | Bayer Healthcare Llc | System and method for syringe engagement with injector |
MX2020010167A (en) * | 2018-03-27 | 2021-02-09 | Injecto Group As | Stopper with low force for use in an injector. |
USD836772S1 (en) | 2018-07-25 | 2018-12-25 | Vertice Pharma, Llc | Syringe |
USD1007676S1 (en) | 2021-11-16 | 2023-12-12 | Regeneron Pharmaceuticals, Inc. | Wearable autoinjector |
WO2023159229A1 (en) | 2022-02-21 | 2023-08-24 | Bayer Healthcare Llc | System, method and device for delivery of a therapeutic or diagnostic agent |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5944694A (en) * | 1996-11-12 | 1999-08-31 | Medrad, Inc. | Prefillable syringes and injectors for use therewith |
Family Cites Families (346)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1265537A (en) | 1918-05-07 | Becton Dickinson Co | Glass syringe. | |
US1687323A (en) | 1921-07-01 | 1928-10-09 | Cook Lab Inc | Medicament cartridge and hypodermic syringe embodying the same |
US1988480A (en) | 1932-05-13 | 1935-01-22 | Campkin Hugh Titford | Hypodermic syringe |
US2392196A (en) | 1945-02-24 | 1946-01-01 | Arthur E Smith | Syringe |
US2419401A (en) | 1946-02-25 | 1947-04-22 | William E Hinds | Syringe plunger seal |
US2702547A (en) | 1950-02-27 | 1955-02-22 | Antonina S Glass | Motor-driven medical injection apparatus and cartridges therefor |
US2842126A (en) | 1954-03-16 | 1958-07-08 | Frederick M Turnbull | Syringe assembly |
US2860635A (en) | 1957-03-20 | 1958-11-18 | Edgar H Wilburn | Sterilizable and sterilized hypodermic syringe assemblies |
US3051173A (en) | 1960-05-12 | 1962-08-28 | Alvin P Johnson | Veterinary hypodermic syringe |
US3270483A (en) | 1963-09-20 | 1966-09-06 | Richardson Merrell Inc | Method and apparatus for assembling syringes |
US3348545A (en) | 1964-10-22 | 1967-10-24 | Sarnoff | Latched cartridge |
DE1486484A1 (en) | 1965-06-24 | 1969-06-04 | Linder Dr Fritz | Bacteria-proof, sealable plastic bag to hold items to be sterilized |
US3623474A (en) | 1966-07-25 | 1971-11-30 | Medrad Inc | Angiographic injection equipment |
BE756550A (en) | 1969-09-23 | 1971-03-01 | Sherwood Medical Ind Inc | REAR LOADING SYRINGE AND PROCEDURE FOR ITS FILLING |
US3645262A (en) | 1969-11-05 | 1972-02-29 | Abbott Lab | Volumetric infant feeding unit |
US3604417A (en) | 1970-03-31 | 1971-09-14 | Wayne Henry Linkenheimer | Osmotic fluid reservoir for osmotically activated long-term continuous injector device |
US3738539A (en) | 1970-05-08 | 1973-06-12 | American Hospital Supply Corp | Syringe with self-returnable plunger |
US3701345A (en) | 1970-09-29 | 1972-10-31 | Medrad Inc | Angiographic injector equipment |
US4370983A (en) | 1971-01-20 | 1983-02-01 | Lichtenstein Eric Stefan | Computer-control medical care system |
US3720211A (en) | 1971-08-18 | 1973-03-13 | G Kyrias | Automatic injection system |
US3752145A (en) | 1971-11-01 | 1973-08-14 | Mdt Instr Co | Method for preventing air embolism in a syringe for angiographic power injector |
CA1016436A (en) | 1971-11-11 | 1977-08-30 | Mpl | Glass tube and thermoplastic finger grip and nose sleeve syringe body assembly |
US3809082A (en) | 1971-12-30 | 1974-05-07 | Ampoules Inc | Plunger tack |
US3796218A (en) | 1972-03-28 | 1974-03-12 | Burron Medical Prod Inc | Syringe adaptor for use with a wet/dry mixing vial |
US3812843A (en) | 1973-03-12 | 1974-05-28 | Lear Siegler Inc | Method and apparatus for injecting contrast media into the vascular system |
GB1380873A (en) | 1973-03-19 | 1975-01-15 | American Hospital Supply Corp | Syringe with self-returnable plunger |
FR2227020B1 (en) | 1973-04-27 | 1975-08-22 | Radiologie Cie Gle | |
US3998224A (en) | 1973-08-15 | 1976-12-21 | Arias Marcelo Chiquiar | Disposable self-destructible syringes which render themselves unreusable |
US4030498A (en) | 1974-10-25 | 1977-06-21 | Baxter Travenol Laboratories, Inc. | Syringe |
US4006736A (en) * | 1974-11-27 | 1977-02-08 | Medrad, Inc. | Angiographic injector |
US3993061A (en) | 1975-02-28 | 1976-11-23 | Ivac Corporation | Syringe pump drive system and disposable syringe cartridge |
US3964139A (en) | 1975-06-16 | 1976-06-22 | Harvard Apparatus Company, Inc. | Syringe holder |
FR2348708A1 (en) | 1976-04-23 | 1977-11-18 | Becton Dickinson France | SYRINGE BULB AND METHOD OF USE |
US4180069A (en) | 1976-06-01 | 1979-12-25 | The West Company | Plunger rod and piston for a syringe |
US4273122A (en) | 1976-11-12 | 1981-06-16 | Whitney Douglass G | Self contained powered injection system |
US4159713A (en) | 1977-06-02 | 1979-07-03 | Becton, Dickinson And Company | Blood gas syringe |
US4155490A (en) | 1977-07-05 | 1979-05-22 | Beckman Instruments, Inc. | Fluid dispenser |
US4148316A (en) | 1977-08-29 | 1979-04-10 | Stewart-Naumann Laboratories, Inc. | Self-sealed hypodermic syringe |
US4180006A (en) | 1978-03-31 | 1979-12-25 | The Singer Company | Tension selecting mechanism for sewing machines |
US4226236A (en) | 1979-05-07 | 1980-10-07 | Abbott Laboratories | Prefilled, vented two-compartment syringe |
DE2919978A1 (en) | 1979-05-15 | 1980-11-20 | Avex Gmbh | Syringe injector jet-protection sleeve - has angular slots forming part of bayonet coupling |
JPS5918427B2 (en) | 1979-10-09 | 1984-04-27 | テルモ株式会社 | gasket for syringe |
US4278086A (en) | 1980-01-28 | 1981-07-14 | Coulter Electronics, Inc. | Variable stop syringe |
US4356822A (en) | 1980-10-17 | 1982-11-02 | Winstead Hall Deborah | Syringe assembly |
US4424720A (en) | 1980-12-15 | 1984-01-10 | Ivac Corporation | Mechanism for screw drive and syringe plunger engagement/disengagement |
US4475666A (en) | 1981-08-31 | 1984-10-09 | American Hospital Supply Corporation | Automated liquid dispenser control |
IT1151940B (en) | 1981-08-03 | 1986-12-24 | Micro Mega Sa | DEVICE FOR SOLIDLY TAKING THE TRANSMISSION COMPLEX IN THE BODY OF A CONTRA-ANGLE FROM DENTISTRY |
US4568335A (en) | 1981-08-28 | 1986-02-04 | Markwell Medical Institute, Inc. | Device for the controlled infusion of medications |
EP0078899B1 (en) | 1981-11-11 | 1986-04-16 | Contraves Ag | Syringe for a sequential injection of two fluids into blood vessels of living bodies |
GB2108852A (en) | 1981-11-20 | 1983-05-25 | Greater Glasgow Health Board | Syringe |
EP0080037B1 (en) | 1981-11-24 | 1985-06-26 | Contraves Ag | Injection device for dispensing controlled amounts of fluid |
SE436687B (en) | 1981-12-14 | 1985-01-21 | Anders Blomberg | INJECTION DEVICE |
US4529401A (en) | 1982-01-11 | 1985-07-16 | Cardiac Pacemakers, Inc. | Ambulatory infusion pump having programmable parameters |
US4476381A (en) | 1982-02-24 | 1984-10-09 | Rubin Martin I | Patient treatment method |
US4452251A (en) | 1982-11-05 | 1984-06-05 | Medrad, Inc. | Syringe content indicating device |
US4465472A (en) | 1982-11-22 | 1984-08-14 | American Hospital Supply Corp. | Syringe cartridge and method |
US4490256A (en) | 1982-11-26 | 1984-12-25 | Sartorius Gmbh | Apparatus for static membrane filtration |
US4500310A (en) | 1982-12-20 | 1985-02-19 | Becton, Dickinson And Company | Variable sealing pressure plunger rod assembly |
CA1231016A (en) | 1983-01-23 | 1988-01-05 | Amir Porat | Syringe |
US4562829A (en) | 1983-02-28 | 1986-01-07 | E. R. Squibb & Sons, Inc. | Strontium-rubidium infusion system |
US4464265A (en) | 1983-06-10 | 1984-08-07 | Joyner Auvin H | Valve device for stock/sauce skimmer and the like |
GB8318670D0 (en) | 1983-07-11 | 1983-08-10 | Ici Plc | Fluid delivery apparatus |
DE3468173D1 (en) | 1983-09-07 | 1988-02-04 | Disetronic Ag | Portable infusion apparatus |
US4604847A (en) | 1983-09-14 | 1986-08-12 | Moulding Jr Thomas S | Medicine package, method of opening the package, and machine for performing the method |
US4749109A (en) | 1983-11-15 | 1988-06-07 | Kamen Dean L | Volumetric pump with replaceable reservoir assembly |
US4648872A (en) | 1983-11-15 | 1987-03-10 | Kamen Dean L | Volumetric pump with replaceable reservoir assembly |
US4664128A (en) | 1983-12-16 | 1987-05-12 | Peter F. Lee, Inc | Single-hand controlled aspiration device |
US4685903A (en) | 1984-01-06 | 1987-08-11 | Pacesetter Infusion, Ltd. | External infusion pump apparatus |
US4854324A (en) | 1984-01-31 | 1989-08-08 | Medrad, Inc. | Processor-controlled angiographic injector device |
US4573978A (en) | 1984-03-15 | 1986-03-04 | Medrad, Inc. | Angiographic syringe and connector for joining a catheter thereto |
ATE37661T1 (en) | 1984-04-14 | 1988-10-15 | Ferring Biotechnik | DEVICE FOR INTERMITTENT APPLICATION OF LIQUID MEDICATIONS. |
US4741732A (en) | 1984-05-10 | 1988-05-03 | The University Of Melbourne | Open-loop control of drug infusion |
EP0164904B1 (en) | 1984-05-10 | 1991-02-27 | The University Of Melbourne | Method of determining an infusion rate profile and infusion device |
EP0346950B2 (en) | 1984-06-06 | 1997-09-10 | Medrad Incorporated | Angiographic syringe for use with an angiographic injector |
USRE35979E (en) | 1984-06-06 | 1998-12-01 | Mtfp, Inc. | Angiographic injector and angiographic syringe for use therewith |
FR2570838B1 (en) | 1984-09-25 | 1986-11-21 | Labo Electronique Physique | APPARATUS FOR EXAMINING MEDIA BY ULTRASONIC ECHOGRAPHY WITH ANGULAR FOCUSING |
US4562844A (en) | 1984-11-27 | 1986-01-07 | Jett Labs, Inc. | Multipurpose syringe |
US4681566A (en) | 1984-11-30 | 1987-07-21 | Strato Medical Corporation | Infusion device |
US4676776A (en) | 1985-01-18 | 1987-06-30 | Intelligent Medicine, Inc. | Device and method for effecting application of a therapeutic agent |
US4652260A (en) | 1985-03-11 | 1987-03-24 | Strato Medical Corporation | Infusion device |
US4838857A (en) | 1985-05-29 | 1989-06-13 | Becton, Dickinson And Company | Medical infusion device |
US4650475A (en) | 1985-07-18 | 1987-03-17 | Carol Smith | Method and apparatus for the injection of pharmaceuticals |
US4612010A (en) | 1985-08-14 | 1986-09-16 | Hamacher Edward N | Infiltration pump |
GB8525109D0 (en) | 1985-10-11 | 1985-11-13 | Vickers Plc | Syringe pumps |
US4636198A (en) | 1985-11-18 | 1987-01-13 | Mallinckrodt, Inc. | Power syringe with volume reducing adapter |
US4628969A (en) | 1985-12-20 | 1986-12-16 | Mallinckrodt, Inc. | Method of producing prefilled sterile plastic syringes |
US4718463A (en) | 1985-12-20 | 1988-01-12 | Mallinckrodt, Inc. | Method of producing prefilled sterile plastic syringes |
US4695271A (en) | 1986-02-03 | 1987-09-22 | Liebel-Flarsheim Company | Angiographic injector |
DE3609672A1 (en) | 1986-03-21 | 1987-09-24 | Klaus Draenert | EVACUABLE BONE CEMENT SYRINGE |
JPH07122650B2 (en) | 1986-07-22 | 1995-12-25 | 中国電力株式会社 | Fault location method |
US4773900A (en) | 1986-08-20 | 1988-09-27 | Cochran Ulrich D | Infusion device |
JPH0747045B2 (en) | 1986-10-15 | 1995-05-24 | 株式会社大協精工 | Stacked syringe stopper |
US4741736A (en) | 1986-12-10 | 1988-05-03 | I-Flow Corporation | Programmable infusion pump |
GB2203047B (en) | 1987-02-27 | 1991-01-30 | Gilbert Henry Banks | Single-use syringe |
US5033650A (en) | 1987-03-09 | 1991-07-23 | Laurence Colin | Multiple barrel dispensing device |
IT1217047B (en) | 1987-03-19 | 1990-03-14 | Cocchi Pietro | INJECTION SYRINGE, INTRAVENOUS SPECIES, MADE TO BE USED ONLY ONCE, WITHOUT POSSIBILITY OF RE-INSPIRATION. |
DE3709783C1 (en) | 1987-03-25 | 1988-04-14 | Blendax Werke Schneider Co | Dosing syringe |
EP0315656B1 (en) | 1987-05-18 | 1993-07-07 | Disetronic Ag | Infusion apparatus |
GB8713810D0 (en) | 1987-06-12 | 1987-07-15 | Hypoguard Uk Ltd | Measured dose dispensing device |
US5034004A (en) | 1987-06-19 | 1991-07-23 | The University Of Melbourne | Infusion pump and drive systems therefor |
US4755172A (en) | 1987-06-30 | 1988-07-05 | Baldwin Brian E | Syringe holder/driver and syringe arrangement and syringe/holder driver therefor |
ATA228987A (en) | 1987-09-09 | 1993-07-15 | Pickhard Ewald | INJECTION DEVICE WITH A DEFORMABLE Vial |
US4842581A (en) | 1987-09-11 | 1989-06-27 | Davis Richard C | Medical lavage apparatus |
NO163263C (en) | 1987-09-15 | 1990-05-02 | Id International As | SELF-DESTROYING INJECTION SPRAYES. |
ES2009497A6 (en) | 1987-11-27 | 1989-10-01 | Candela Estruch Miracle | Syringe for one sole use. |
US4878896A (en) | 1987-12-01 | 1989-11-07 | Pacesetter Infusion, Ltd. | Cassette optical identification apparatus for a medication infusion system |
US4863425A (en) | 1987-12-04 | 1989-09-05 | Pacesetter Infusion, Ltd. | Patient-side occlusion detection system for a medication infusion system |
FR2625102B1 (en) | 1987-12-24 | 1994-06-10 | Godefroy Alain | IMPROVEMENT ON UNIVERSAL SYRINGES |
US4853521A (en) | 1987-12-28 | 1989-08-01 | Claeys Ronald W | System for verifying and recording drug administration to a patient |
AU636286B2 (en) | 1988-01-07 | 1993-04-29 | Bernard Hazon | Syringe-pushing device for ambulant administration of parenteral injections, with flow rate governed by the contents of the syringe |
US4932941A (en) | 1988-03-14 | 1990-06-12 | Min Kyung M | Non-reusable disposable syringe |
FR2628635B1 (en) | 1988-03-21 | 1992-10-23 | Microtechnic Sa | SINGLE USE SYRINGE |
WO1989009071A1 (en) | 1988-03-25 | 1989-10-05 | Merit Medical Systems, Inc. | Disposable control syringe |
AU3366089A (en) | 1988-03-28 | 1989-10-16 | Sang Don Lee | Locking needle assembly in a hypodermic syringe |
US5085638A (en) | 1988-03-31 | 1992-02-04 | David Farbstein | Single use disposable syringe |
US4869720A (en) | 1988-05-05 | 1989-09-26 | E-Z-Em, Inc. | Hypodermic syringe assembly |
IT1217595B (en) | 1988-05-13 | 1990-03-30 | Molteni & C | ANTI-CONTACT DEVICE FOR INJECTION OF DENTAL ANESTHETIC SOLUTIONS CONTAINED IN CARTRIDGE |
WO1989011310A1 (en) | 1988-05-16 | 1989-11-30 | Spinello Ronald P | Aspirating hypodermic syringe apparatus and method |
US4931043A (en) | 1988-08-08 | 1990-06-05 | Sterling Drug Inc. | Ratchet connector for hypodermic syringe pistons |
JP2717808B2 (en) | 1988-08-10 | 1998-02-25 | テルモ株式会社 | Syringe pump |
US4908022A (en) | 1988-08-15 | 1990-03-13 | Habley Medical Technology Corporation | Disposable safety syringe having a retractable needle cannula and cannula lock |
NL8802106A (en) | 1988-08-26 | 1990-03-16 | Abraham Van Den Haak | NEEDLE PROTECTION FOR AN INJECTION SYRINGE. |
US4943279A (en) | 1988-09-30 | 1990-07-24 | C. R. Bard, Inc. | Medical pump with infusion controlled by a detachable coded label |
US4923443A (en) | 1988-10-04 | 1990-05-08 | Greenwood Eugene C | Single use syringe |
US4929238A (en) | 1988-11-23 | 1990-05-29 | Coeur Laboratories, Inc. | Multi-pressure injector device |
US5000735A (en) | 1989-01-05 | 1991-03-19 | The Regents Of The Univ. Of California | Single use syringe |
US5007904A (en) | 1989-01-19 | 1991-04-16 | Coeur Laboratories, Inc. | Plunger for power injector angiographic syringe, and syringe comprising same |
US5153827A (en) | 1989-01-30 | 1992-10-06 | Omni-Flow, Inc. | An infusion management and pumping system having an alarm handling system |
GB8903581D0 (en) | 1989-02-16 | 1989-04-05 | Metal Box Plc | Injection moulding |
US5093079A (en) | 1989-03-02 | 1992-03-03 | Bakaitis Teresa L | Sterilization apparatus and related process |
US4911695A (en) | 1989-04-03 | 1990-03-27 | Coeur Laboratories, Inc. | Plunger for power-driven angiographic syringe, and syringe and power injector system utilizing same |
DE3912405C1 (en) | 1989-04-15 | 1990-10-31 | B. Braun Melsungen Ag, 3508 Melsungen, De | |
US5090962A (en) | 1989-04-28 | 1992-02-25 | Flp Enterprises, Inc. | Non-reusable syringe |
US5094148A (en) * | 1989-05-08 | 1992-03-10 | Habley Medical Technology Corporation | Piston stem insert for a carpule based piston |
US5059179A (en) | 1989-05-15 | 1991-10-22 | David Quatrochi | Non-reusable syringe assembly |
US5085643A (en) | 1989-06-02 | 1992-02-04 | Abbott Laboratories | Syringe, adaptor, and check valve combination for parenteral infuser |
US4978335A (en) | 1989-09-29 | 1990-12-18 | Medex, Inc. | Infusion pump with bar code input to computer |
US5084017A (en) | 1989-10-10 | 1992-01-28 | John Maffetone | Self disabling, single use, hypodermic syringe |
US5104374A (en) | 1990-01-16 | 1992-04-14 | Bishko Jay R | Electronic fluid flow rate controller for controlling the infusion of intravenous drugs into a patient |
US5024663A (en) | 1990-02-21 | 1991-06-18 | Alza Corporation | Self-contained suction pump |
US5078683A (en) | 1990-05-04 | 1992-01-07 | Block Medical, Inc. | Programmable infusion system |
US5135507A (en) | 1990-05-10 | 1992-08-04 | Habley Medical Technology Corporation | One-piece syringe |
IT219694Z2 (en) | 1990-05-25 | 1993-04-26 | Habley Medical Technology Corp | DISPOSABLE SYRINGE, DISPOSABLE |
DE4017920A1 (en) | 1990-06-05 | 1991-12-12 | Joachim Cholewa | Disposable syringe with bifurcated sealing lip - avoiding piston sealing deterioration on storage with thermoplastic polyethylene sealing lip |
US5354287A (en) | 1991-01-16 | 1994-10-11 | Senetek Plc | Injector for delivering fluid to internal target tissue |
US5256157A (en) | 1991-01-31 | 1993-10-26 | Baxter International Inc. | Automated infusion pump with replaceable memory cartridges |
US5176642A (en) | 1991-03-11 | 1993-01-05 | Mectra Labs, Inc. | Vacuum powdered syringe |
US5106379A (en) | 1991-04-09 | 1992-04-21 | Leap E Jack | Syringe shielding assembly |
US5106372A (en) | 1991-05-03 | 1992-04-21 | Sherwood Medical Company | Single use syringe |
EP0514907B1 (en) | 1991-05-23 | 1996-07-10 | Ivac Corporation | Syringe plunger driver system |
US5236416A (en) | 1991-05-23 | 1993-08-17 | Ivac Corporation | Syringe plunger position detection and alarm generation |
US5300031A (en) | 1991-06-07 | 1994-04-05 | Liebel-Flarsheim Company | Apparatus for injecting fluid into animals and disposable front loadable syringe therefor |
US5282858A (en) | 1991-06-17 | 1994-02-01 | American Cyanamid Company | Hermetically sealed implantable transducer |
DE59208160D1 (en) | 1991-07-13 | 1997-04-17 | Hydraulik Techniek | Actuator operated by pressure medium, in particular for a lifting, lifting or pushing device |
US5425716A (en) | 1991-08-09 | 1995-06-20 | Atom Kabushiki Kaisha | Infusion apparatus |
AT397467B (en) | 1991-10-22 | 1994-04-25 | Wimmer Erwin | DISPOSABLE SYRINGE |
US5246423A (en) | 1991-11-01 | 1993-09-21 | Farkas Paul J | Remote cannula removal hypodermic syringe |
US5181912A (en) | 1991-12-05 | 1993-01-26 | Roy Hammett | Non-reusable syringe |
US5352202A (en) | 1991-12-05 | 1994-10-04 | Roy Hammett | Non-reusable syringe with removable plunger usable as a needle guard |
US5256154A (en) | 1992-01-31 | 1993-10-26 | Sterling Winthrop, Inc. | Pre-filled plastic syringes and containers and method of terminal sterilization thereof |
US5226897A (en) | 1992-02-28 | 1993-07-13 | Professional Medical Products, Inc. | Manually driven piston syringe with frangibly mounted tube adapter |
US5356375A (en) | 1992-04-06 | 1994-10-18 | Namic U.S.A. Corporation | Positive pressure fluid delivery and waste removal system |
US5269762A (en) | 1992-04-21 | 1993-12-14 | Sterling Winthrop, Inc. | Portable hand-held power assister device |
US5295966A (en) | 1992-04-29 | 1994-03-22 | Becton, Dickinson And Company | Syringe pump with biased lockable syringe clamp |
FR2690622B1 (en) | 1992-04-29 | 1995-01-20 | Chronotec | Programmable ambulatory infusion pump system. |
US5259732A (en) | 1992-04-29 | 1993-11-09 | Becton, Dickinson And Company | Syringe pump with syringe barrel position detector |
US5267962A (en) | 1992-06-10 | 1993-12-07 | Jenson Robert W | Disposable hypodermic syringe with needle safe feature |
SE9202052L (en) | 1992-07-02 | 1994-01-03 | Goeran Helldin | A rod and piston unit useful in a disposable syringe and a way of mounting a syringe while utilizing such a unit |
US5338309A (en) | 1992-07-21 | 1994-08-16 | Becton, Dickinson And Company | Syringe having two component barrel |
US5282792A (en) | 1992-07-21 | 1994-02-01 | Becton, Dickinson And Company | Syringe having two component barrel |
US5254086A (en) | 1992-07-31 | 1993-10-19 | Ballard Medical Products | Medical lavage apparatus and methods |
US5342298A (en) | 1992-07-31 | 1994-08-30 | Advanced Cardiovascular Systems, Inc. | Automated fluid pressure control system |
US5383858B1 (en) * | 1992-08-17 | 1996-10-29 | Medrad Inc | Front-loading medical injector and syringe for use therewith |
US6402718B1 (en) | 1992-08-17 | 2002-06-11 | Medrad, Inc. | Front-loading medical injector and syringe for use therewith |
SE9202423L (en) | 1992-08-25 | 1993-09-06 | Nils Goeran Helldin | SYRINGE |
US5308330A (en) | 1992-09-16 | 1994-05-03 | Becton, Dickinson And Company | Syringe having needle isolation features |
US5242408A (en) | 1992-09-23 | 1993-09-07 | Becton, Dickinson And Company | Method and apparatus for determining pressure and detecting occlusions in a syringe pump |
US5324273A (en) | 1992-09-30 | 1994-06-28 | Centrix, Inc. | Disposable barrel dental impression material syringe |
ES2154651T3 (en) | 1992-10-15 | 2001-04-16 | Gen Hospital Corp | INFUSION PUMP WITH ELECTRONICALLY CHARGABLE MEDICATIONS LIBRARY. |
US5254101A (en) | 1992-11-27 | 1993-10-19 | Medrad, Inc. | Fluid presence indicator for rotatable syringe |
US5373684A (en) | 1992-12-14 | 1994-12-20 | Mallinckrodt Medical, Inc. | Process and apparatus used in producing prefilled, sterile delivery devices |
US5353691A (en) | 1993-04-14 | 1994-10-11 | Habley Medical Technology Corp. | Self-lubricating piston for pharmaceutical container |
GB9309151D0 (en) | 1993-05-04 | 1993-06-16 | Zeneca Ltd | Syringes and syringe pumps |
US5433712A (en) | 1993-06-10 | 1995-07-18 | Donald E. Stiles | Self-sheathing hypodermic syringe |
US5429611A (en) | 1993-06-10 | 1995-07-04 | Rait; Joseph M. | Syringe with automatically actuated shield |
US5389075A (en) | 1993-06-14 | 1995-02-14 | Vladimirsky; Roman | Single-use hypodermic syringe |
US5314415A (en) | 1993-07-21 | 1994-05-24 | Sterling Winthrop Inc. | Aspirating plunger for power injector cartridges |
US5336189A (en) | 1993-08-23 | 1994-08-09 | Sealfon Andrew I | Combination IV pump and disposable syringe |
EP0717611B1 (en) | 1993-09-07 | 1998-08-12 | Debiotech S.A. | Syringe device for mixing two compounds |
US5827219A (en) | 1993-10-28 | 1998-10-27 | Medrad, Inc. | Injection system and pumping system for use therein |
US5431627A (en) | 1993-11-12 | 1995-07-11 | Abbott Laboratories | Cassette identification system for use with a multi-program drug infusion pump |
US5531697A (en) | 1994-04-15 | 1996-07-02 | Sims Deltec, Inc. | Systems and methods for cassette identification for drug pumps |
CA2129284C (en) | 1993-11-24 | 1999-03-09 | Kenneth J. Niehoff | Controlling plunger drives for fluid injection in animals |
US5397313A (en) * | 1994-01-27 | 1995-03-14 | The Kendall Company | Low friction syringe |
US5439452A (en) | 1994-01-31 | 1995-08-08 | Children's Medical Ventures, Inc. | Limit stop valve infusion device |
US5535746A (en) | 1994-03-29 | 1996-07-16 | Sterling Winthrop Inc. | Prefilled syringe for use with power injector |
US5413563A (en) | 1994-05-06 | 1995-05-09 | Sterling Winthrop Inc. | Pre-filled syringe having a plunger, plunger insert and plunger rod |
US5411488A (en) | 1994-05-06 | 1995-05-02 | Sterling Winthrop Inc. | Pre-filled syringe and pre-filled cartridge having an improved plunger and plunger rod for reducing syringing force |
US5722951A (en) | 1994-07-14 | 1998-03-03 | Marano; Carlos Jose | Hypodermic non-reusable syringes without voluntary intervention of the user |
US5840026A (en) | 1994-09-21 | 1998-11-24 | Medrad, Inc. | Patient specific dosing contrast delivery systems and methods |
US5688252A (en) | 1994-09-30 | 1997-11-18 | Takeda Chemical Industries, Ltd. | Syringe |
US5533981A (en) | 1994-10-06 | 1996-07-09 | Baxter International Inc. | Syringe infusion pump having a syringe plunger sensor |
US5695477A (en) | 1994-10-28 | 1997-12-09 | Sfikas; John | Needle ejector safety system |
US5484413A (en) | 1994-11-23 | 1996-01-16 | Alexis M. Gevorgian | Disposable medical syringe with safety protection |
US5445622A (en) | 1994-12-20 | 1995-08-29 | Brown; Eric W. | Flow switch device for medical applications |
US5478314A (en) | 1994-12-27 | 1995-12-26 | Malenchek; Robert | Non-reusable syringe |
DE19601214A1 (en) | 1995-02-20 | 1996-08-22 | Lang Volker | Device for taking blood |
US5531710A (en) | 1995-02-24 | 1996-07-02 | Courtaulds Aerospace, Inc. | Combination closure and syringe |
US5683367A (en) | 1995-03-06 | 1997-11-04 | Sabratek Corporation | Infusion pump with different operating modes |
FR2731622B1 (en) | 1995-03-13 | 1997-09-19 | Vygon | APPARATUS FOR INJECTION OF A LIQUID |
US5785682A (en) | 1995-03-22 | 1998-07-28 | Abbott Laboratories | Pre-filled syringe drug delivery system |
IT235830Y1 (en) | 1995-04-06 | 2000-07-18 | Borla Ind | "LUER-LOCK FITTING WITH PROTECTION CAP FOR MEDICATION LINES-INFUSION-TRANSFUSION." |
AUPN254195A0 (en) | 1995-04-20 | 1995-05-18 | Curie, Napoleon | Syringe with retractable needle mount |
US5882343A (en) | 1995-04-20 | 1999-03-16 | Invasatec, Inc. | Dual port syringe |
US5573515A (en) | 1995-04-20 | 1996-11-12 | Invasatec, Inc. | Self purging angiographic injector |
ES2208740T3 (en) | 1995-04-20 | 2004-06-16 | Acist Medical Systems, Inc. | AUTOPURGADOR ANGIOGRAPHIC INJECTOR. |
US6099502A (en) | 1995-04-20 | 2000-08-08 | Acist Medical Systems, Inc. | Dual port syringe |
US6221045B1 (en) | 1995-04-20 | 2001-04-24 | Acist Medical Systems, Inc. | Angiographic injector system with automatic high/low pressure switching |
US5512054A (en) | 1995-05-16 | 1996-04-30 | American Medical Systems, Inc. | Dual action syringe |
US5779675A (en) | 1995-08-25 | 1998-07-14 | Medrad, Inc. | Front load pressure jacket system with syringe holder |
US5520653A (en) | 1995-09-01 | 1996-05-28 | Medrad, Inc. | Syringe adapter for front-loading medical injector |
US5807334A (en) | 1995-10-20 | 1998-09-15 | Hodosh; Milton | Fluid dispensing apparatus |
US5899879A (en) | 1995-12-19 | 1999-05-04 | Genesis Medical Technologies, Inc. | Spring-actuated needleless injector |
US5735825A (en) | 1996-03-22 | 1998-04-07 | Merit Medical Systems, Inc. | Syringe plunger tip |
EP0956085A4 (en) | 1996-03-29 | 2002-11-06 | Medrad Inc | Front-loading syringe adapter for front-loading medical injector |
US5738655A (en) | 1996-07-15 | 1998-04-14 | Vallelunga; Anthony J. | Nonrefillable syringe |
DE19633530A1 (en) | 1996-08-20 | 1998-02-26 | Claus H Dr Ing Backes | Medical high pressure injection system |
US6042565A (en) | 1996-10-18 | 2000-03-28 | Medrad, Inc. | Syringe, injector and injector system |
US5947935A (en) | 1996-11-12 | 1999-09-07 | Medrad, Inc. | Syringes, syringe plungers and injector systems |
US5873861A (en) | 1996-11-12 | 1999-02-23 | Medrad, Inc. | Plunger systems |
JP3648254B2 (en) | 1996-11-12 | 2005-05-18 | メドラッド インコーポレーテッド | Prefillable syringes and plungers and injectors used with them |
US5902276A (en) * | 1996-11-26 | 1999-05-11 | Liebel-Flarsheim Company | Two-shot molded plunger |
US5782803A (en) * | 1996-11-26 | 1998-07-21 | Jentzen; S. William | Low dead space, interchangeable needle syringe |
US6083200A (en) | 1996-11-27 | 2000-07-04 | Sse System Services Establishment | Medical syringe |
US5938637A (en) | 1997-03-14 | 1999-08-17 | Path | Single-use medicine delivery unit for needleless hypodermic injector |
US5741227A (en) | 1997-04-11 | 1998-04-21 | Sealfon; Andrew I. | Method of sterile preparation of IV pump syringe |
US5808203A (en) | 1997-05-12 | 1998-09-15 | Medrad, Inc. | Fluid pressure measurement devices |
US5913844A (en) | 1997-06-17 | 1999-06-22 | Liebel-Flarsheim Company | Power injector and method providing removal of used disposable syringe |
US5865805A (en) | 1997-07-16 | 1999-02-02 | Liebel-Flarsheim Company | Power injector and side loadable syringe support therefor for plunger pushrod type syringes |
US6764466B1 (en) | 1997-07-18 | 2004-07-20 | Liebel Flarsheim Company | Adapter and syringe for front-loading medical fluid injector |
US6569127B1 (en) | 1997-07-18 | 2003-05-27 | Liebel-Flarsheim Company | Adapter and syringe for front-loading medical fluid injector |
US6533758B1 (en) | 1997-07-18 | 2003-03-18 | Liebel-Flarsheim Company | Adapter and syringe for front-loading medical fluid injector |
US5947929A (en) | 1997-08-22 | 1999-09-07 | Coeur Laboratories, Inc. | Front-load angiographic injector system, angiographic syringe and plunger for angiographic syringe |
US6080136A (en) | 1998-06-11 | 2000-06-27 | Polyten Plastics, Llc | Angiographic syringe adapter for front-loading injector |
US6004300A (en) * | 1997-08-28 | 1999-12-21 | Butcher; Robert M | Composite hypodermic syringe piston |
DE69836896T2 (en) | 1997-11-26 | 2007-11-08 | Liebel-Flarsheim Co., Cincinnati | Front loading syringe pump and method of loading with a flanged syringe |
US5954700A (en) | 1998-01-13 | 1999-09-21 | Minimed Inc. | Medication cartridge for an electronic pen-type injector, or the like, and method of making the same |
US6224577B1 (en) * | 1998-03-02 | 2001-05-01 | Medrad, Inc. | Syringes and plungers for use therein |
US5954697A (en) | 1998-03-02 | 1999-09-21 | Srisathapat; Chad | Threaded nut syringe plunger for use with a medication infusion pump |
US5919167A (en) | 1998-04-08 | 1999-07-06 | Ferring Pharmaceuticals | Disposable micropump |
CA2236049C (en) | 1998-04-27 | 2006-07-25 | Computer Controlled Syringe Inc. | Syringe with detachable syringe barrel |
JP4132208B2 (en) | 1998-04-28 | 2008-08-13 | 大成化工株式会社 | Syringe container manufacturing apparatus and syringe container manufacturing method |
JP2002518108A (en) | 1998-06-15 | 2002-06-25 | メドラッド インコーポレイテッド | Encoding syringe information |
US6817990B2 (en) * | 1998-10-29 | 2004-11-16 | Medtronic Minimed, Inc. | Fluid reservoir piston |
US6059756A (en) | 1998-11-04 | 2000-05-09 | Yeh; Song-Hwa | Safety injection device |
JP2000140103A (en) | 1998-11-05 | 2000-05-23 | Daikyo Seiko Ltd | Plunger for injector |
JP2000152989A (en) | 1998-11-19 | 2000-06-06 | Bracco Internatl Bv | Injector and cartridge and plunger ring therefor |
US6267749B1 (en) | 1998-12-29 | 2001-07-31 | Safeguard Medical Limited | Single use syringe with breakaway plunger |
US6196999B1 (en) | 1999-02-05 | 2001-03-06 | Liebel-Flarsheim Company | Syringe/plunger coupling |
US6645177B1 (en) | 1999-02-09 | 2003-11-11 | Alaris Medical Systems, Inc. | Directly engaged syringe driver system |
US6345262B1 (en) | 1999-04-23 | 2002-02-05 | Martin P. Madden | System and method for implementing a mortgage plan |
US6669663B1 (en) | 1999-04-30 | 2003-12-30 | Medtronic, Inc. | Closed loop medicament pump |
JP2001029466A (en) | 1999-07-15 | 2001-02-06 | Hiroshi Motobayashi | Prefilled syringe |
US6339718B1 (en) | 1999-07-30 | 2002-01-15 | Medrad, Inc. | Programmable injector control |
IT1307266B1 (en) | 1999-08-13 | 2001-10-30 | Cane Srl | APPARATUS FOR INFUSION OF DRUGS. |
US6517516B1 (en) | 1999-10-15 | 2003-02-11 | Becton Dickinson And Company | Method of making a retracting needle syringe |
US6958053B1 (en) | 1999-11-24 | 2005-10-25 | Medrad, Inc. | Injector providing drive member advancement and engagement with syringe plunger, and method of connecting a syringe to an injector |
ES2287041T3 (en) | 1999-11-24 | 2007-12-16 | Medrad, Inc. | FRONT LOAD AND SYRINGE INJECTOR. |
WO2001041835A2 (en) | 1999-12-07 | 2001-06-14 | Medrad, Inc. | Syringes, syringe tubing and fluid transfer systems |
US6652489B2 (en) | 2000-02-07 | 2003-11-25 | Medrad, Inc. | Front-loading medical injector and syringes, syringe interfaces, syringe adapters and syringe plungers for use therewith |
US6432089B1 (en) | 2000-06-21 | 2002-08-13 | Medrad, Inc. | Medical syringe |
AUPQ867900A0 (en) | 2000-07-10 | 2000-08-03 | Medrad, Inc. | Medical injector system |
WO2002007812A2 (en) | 2000-07-20 | 2002-01-31 | Acist Medical Systems, Inc. | Syringe plunger locking mechanism |
US6511459B1 (en) * | 2000-09-29 | 2003-01-28 | Mallinckrodt Inc. | Syringe plunger having an improved sealing ability |
US6585700B1 (en) * | 2000-10-05 | 2003-07-01 | Medrad, Inc. | Syringe, syringe plunger and attachment mechanism for front loading medical injector |
US7462166B2 (en) | 2000-12-11 | 2008-12-09 | Medrad, Inc. | Encoding and sensing of syringe information |
US7044931B2 (en) * | 2000-12-13 | 2006-05-16 | Hypoguard Usa Inc. | Syringe with retractable needle assembly |
US7018363B2 (en) | 2001-01-18 | 2006-03-28 | Medrad, Inc. | Encoding and sensing of syringe information |
US6854620B2 (en) | 2001-04-13 | 2005-02-15 | Nipro Diabetes, Systems, Inc. | Drive system for an infusion pump |
JP4073313B2 (en) | 2001-04-27 | 2008-04-09 | ハイドロシジョン・インコーポレーテッド | High pressure pumping cartridge for medical and surgical pumping and infusion devices |
US7501092B2 (en) | 2001-06-06 | 2009-03-10 | Nomadics, Inc. | Manganese doped upconversion luminescence nanoparticles |
EP1273316A1 (en) | 2001-07-02 | 2003-01-08 | Sergio Restelli | Disposable safety syringe |
US7549977B2 (en) | 2002-12-20 | 2009-06-23 | Medrad, Inc. | Front load pressure jacket system with syringe holder and light illumination |
US7291126B2 (en) | 2001-11-26 | 2007-11-06 | Nilimedix Ltd. | Drug delivery device and method |
EP1455870B1 (en) | 2001-12-06 | 2007-08-08 | Novo Nordisk A/S | A medical delivery system |
TW552947U (en) | 2002-02-08 | 2003-09-11 | Jian-Wei Jung | Injector with easy detachment of push rod after retraction |
US20030163089A1 (en) | 2002-02-28 | 2003-08-28 | Bynum Gail Beth | Child safety cap for syringe pump |
US7553294B2 (en) | 2002-05-30 | 2009-06-30 | Medrad, Inc. | Syringe plunger sensing mechanism for a medical injector |
US7125394B2 (en) | 2002-06-04 | 2006-10-24 | Syringe, Llc | Applicator for dispensing a medicinal substance |
US20030236800A1 (en) | 2002-06-19 | 2003-12-25 | Goeltzenleuchter Courtney D. | Dynamic recovery system and method |
WO2004000392A1 (en) | 2002-06-25 | 2003-12-31 | Medrad, Inc. | Devices, systems and methods for injecting multiple fluids into a patient |
BE1015362A6 (en) | 2002-10-14 | 2005-02-01 | Boutech Nv | Manufacture of plungers for medical syringes comprises forming plunger or its part through manufacturing a piston body and plunger body or its part using injection molding, and injecting plunger body or its part against piston body |
US6983590B2 (en) | 2002-10-22 | 2006-01-10 | General Motors Corporation | Secondary air injection diagnostic system using pressure feedback |
US20040243067A1 (en) | 2003-02-03 | 2004-12-02 | Sibbitt Wilmer L. | Multidiameter syringe families |
US20040186437A1 (en) * | 2003-03-20 | 2004-09-23 | Frenette Claude E. | Content-coded medical syringe, syringe set and syringe content identification method |
US20040243022A1 (en) | 2003-04-29 | 2004-12-02 | Medtronic Vascular, Inc. | Method and system of detecting vulnerable plaque by sensing motion of thin fibrous cap |
JP4338447B2 (en) | 2003-06-06 | 2009-10-07 | 株式会社根本杏林堂 | Chemical injection system |
US7419478B1 (en) | 2003-06-25 | 2008-09-02 | Medrad, Inc. | Front-loading syringe for medical injector having a flexible syringe retaining ring |
US7399293B2 (en) | 2003-07-30 | 2008-07-15 | Becton, Dickinson And Company | Syringe assembly having disabling mechanism with tamper resistance features |
US7666169B2 (en) | 2003-11-25 | 2010-02-23 | Medrad, Inc. | Syringe and syringe plungers for use with medical injectors |
US7497843B1 (en) | 2004-03-12 | 2009-03-03 | Medrad, Inc. | Syringe interfaces, syringe adapters and injector systems |
US20050240149A1 (en) | 2004-04-23 | 2005-10-27 | Lu Chun H | Self-destructive syringe |
EP1825875A4 (en) | 2004-11-26 | 2012-12-26 | Nemoto Kyorindo Co Ltd | Medical fluid injection system |
US7407495B2 (en) | 2004-12-21 | 2008-08-05 | Becton Dickinson And Company | Syringe assembly having disabling mechanism |
ES2349749T3 (en) | 2004-12-21 | 2011-01-11 | BECTON, DICKINSON & COMPANY | SYRINGE ASSEMBLY THAT HAS A USE MECHANISM. |
FR2880809B1 (en) | 2005-01-17 | 2007-02-23 | Fresenius Vial Soc Par Actions | RETENTION DEVICE FOR BLOCKING THE PISTON HEAD OF A SYRINGE ON THE PUSHER OF A SYRINGE PUSHER |
US20070123830A1 (en) | 2005-11-29 | 2007-05-31 | Addino B.V. | Safety syringe |
US8926569B2 (en) * | 2006-03-15 | 2015-01-06 | Bayer Medical Care Inc. | Plunger covers and plungers for use in syringes and methods of fabricating plunger covers and plungers for use in syringes |
AT502791B1 (en) | 2006-04-06 | 2007-05-15 | Pharma Consult Ges M B H & Co | Injection syringe, has plastic needle holder enclosing stainless steel injection needle, where holder receives injection solution in relation to interior of cylinder and is sealed off by sealing insert, by which rear end of needle protrudes |
JP5113835B2 (en) | 2006-05-10 | 2013-01-09 | メドラッド インコーポレーテッド | Front-loading medical injector and syringe used therewith |
EP1894590B1 (en) | 2006-08-30 | 2012-04-25 | Roche Diagnostics GmbH | Injection device with simplified retaining of a stopper |
US8038656B2 (en) | 2006-09-29 | 2011-10-18 | Tyco Healthcare Group Lp | Detachable plunger rod syringe |
US8672893B2 (en) | 2007-10-23 | 2014-03-18 | Control Medical Technology, Llc | Syringe with rotatable element, aspiration systems including the syringe, and associated methods |
ITTO20060816A1 (en) | 2006-11-16 | 2008-05-17 | Cane Srl | STRIPE FOR SYRINGE AND SYRINGE THAT ENCOURAGES THE STOVE |
GB0700334D0 (en) | 2007-01-09 | 2007-02-14 | Imi Vision Ltd | Pump |
US7803134B2 (en) | 2007-01-10 | 2010-09-28 | Animas Corporation | Syringe assembly and infusion pump assembly incorporating such |
US8740856B2 (en) | 2007-06-04 | 2014-06-03 | Becton, Dickinson And Company | Stoppers used in pre-filled syringes |
AU2008261084B2 (en) | 2007-06-04 | 2011-07-28 | Becton, Dickinson And Company | Positive displacement stopper for a pre-filled syringe |
ATE528034T1 (en) | 2007-08-13 | 2011-10-15 | Mallinckrodt Llc | DRIVE Plunger FOR MEDICAL INJECTION DEVICES |
AU317487S (en) | 2007-09-21 | 2008-01-08 | Imaxeon Pty Ltd | A plunger |
WO2009120692A2 (en) | 2008-03-25 | 2009-10-01 | Animal Innovations, Inc. | Syringe mechanism for detecting syringe status |
US8613730B2 (en) | 2008-11-26 | 2013-12-24 | Acist Medical Systems, Inc. | Apparatus and methods for fluid pressurizing units of injection systems |
AU2010226442A1 (en) | 2009-03-20 | 2011-10-13 | Antares Pharma, Inc. | Hazardous agent injection system |
AU2010243738B2 (en) | 2009-04-30 | 2014-10-09 | Sanofi-Aventis Deutschland Gmbh | Axially adjustable connection of piston rod to piston for drive mechanism of a drug delivery device |
CN102458521B (en) | 2009-06-04 | 2014-06-04 | 诺沃—诺迪斯克保健股份有限公司 | Mixing device with piston coupling arrangement |
GB2470935A (en) | 2009-06-11 | 2010-12-15 | David Howell Jenkins | Single use syringe hub with moveable bung |
EP2735376B1 (en) | 2009-07-24 | 2017-08-23 | Bayer Healthcare LLC | Syringe for a fluid injector system |
US8628495B2 (en) | 2009-08-13 | 2014-01-14 | Mallinckrodt Llc | Power injector syringe assembly |
EP2484393B1 (en) | 2009-09-30 | 2014-07-30 | Terumo Kabushiki Kaisha | Pre-filled syringe |
TWI619521B (en) | 2009-12-15 | 2018-04-01 | 艾伯維生物技術有限責任公司 | Automatic injection device, automatic injection method and method for preventing misfiring |
US8172795B2 (en) | 2010-03-15 | 2012-05-08 | Becton, Dickinson And Company | Medical device including an air evacuation system |
WO2012021801A2 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
GB201020472D0 (en) | 2010-12-02 | 2011-01-19 | Oval Medical Technologies Ltd | A drive assembly for an autoinjector |
EP2489387A1 (en) | 2011-02-18 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
WO2012124028A1 (en) | 2011-03-11 | 2012-09-20 | スーガン株式会社 | Joint mechanism |
JP5969464B2 (en) | 2011-03-29 | 2016-08-17 | テルモ株式会社 | Syringe |
CA3033560C (en) | 2011-05-12 | 2021-03-02 | Bayer Healthcare Llc | Fluid injection system having various systems for controlling an injection procedure |
TWI455736B (en) | 2012-02-13 | 2014-10-11 | Chih Ming Wang | Multiple needle |
TWI551319B (en) | 2012-06-15 | 2016-10-01 | Fan Xiao Yi | A push rod with a card retracting structure |
US9174003B2 (en) | 2012-09-28 | 2015-11-03 | Bayer Medical Care Inc. | Quick release plunger |
AU2014260230B2 (en) | 2013-05-01 | 2019-02-14 | Unl Holdings Llc | Plunger-driven auto-injectors |
US20160151570A1 (en) | 2013-07-10 | 2016-06-02 | Bayer Healthcare Llc | Vacuum system for a piston and syringe interface |
KR102497204B1 (en) | 2014-10-28 | 2023-02-06 | 바이엘 헬쓰케어 엘엘씨 | Self-orienting pressure jacket and pressure jacket-to-injector interface |
NO2689315T3 (en) | 2014-10-28 | 2018-04-14 | ||
AU2015339382A1 (en) | 2014-10-28 | 2017-05-11 | Bayer Healthcare Llc | Self-orienting pressure jacket and pressure jacket-to-injector interface |
US9199033B1 (en) | 2014-10-28 | 2015-12-01 | Bayer Healthcare Llc | Self-orienting syringe and syringe interface |
-
2007
- 2007-03-14 US US11/686,000 patent/US8926569B2/en active Active
-
2014
- 2014-12-19 US US14/576,354 patent/US9855390B2/en active Active
-
2017
- 2017-12-22 US US15/851,860 patent/US10668221B2/en active Active
-
2020
- 2020-06-02 US US16/946,008 patent/US20200289765A1/en not_active Abandoned
-
2022
- 2022-11-02 US US18/052,050 patent/US20230166042A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5944694A (en) * | 1996-11-12 | 1999-08-31 | Medrad, Inc. | Prefillable syringes and injectors for use therewith |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11883636B2 (en) | 2018-02-27 | 2024-01-30 | Bayer Healthcare Llc | Syringe plunger engagement mechanism |
Also Published As
Publication number | Publication date |
---|---|
US8926569B2 (en) | 2015-01-06 |
US20230166042A1 (en) | 2023-06-01 |
US10668221B2 (en) | 2020-06-02 |
US20180021519A9 (en) | 2018-01-25 |
US20180117258A1 (en) | 2018-05-03 |
US9855390B2 (en) | 2018-01-02 |
US20150105736A1 (en) | 2015-04-16 |
US20070219508A1 (en) | 2007-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20200289765A1 (en) | Plunger covers and plungers for use in syringes | |
US6004300A (en) | Composite hypodermic syringe piston | |
EP1064038B1 (en) | Syringes and plungers for use therein | |
US8517997B2 (en) | Dispenser for medicaments and method and apparatus for making same | |
US7111848B2 (en) | Gasket and method of manufacturing the gasket | |
US20100280370A1 (en) | Syringe plunger | |
US8747726B2 (en) | Method of manufacturing syringes and other devices | |
US20160303346A1 (en) | Catheter assemblies and injection molding processes and equipment for making the same | |
JP4491410B2 (en) | Method and apparatus for manufacturing a plunger for a medical syringe, plunger obtained thereby, and medical syringe | |
KR20150127212A (en) | Connector assembly for syringe system | |
CN103533977A (en) | Plastic stopper | |
US10130771B2 (en) | Syringe barrel and mold for injection molding | |
TWI664988B (en) | Syringe, syringe plunger with dynamic seal, and methods of making a plunger and a syringe | |
TW469138B (en) | Check valve and syringe using the same | |
JP2023516899A (en) | Continuous tube with alternating composition for medical device | |
CA3199192A1 (en) | Barrier coated stopper and method of forming same | |
JP4797718B2 (en) | Plug with integrated dissimilar materials | |
JP2001289326A (en) | Gasket and syringe |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: BAYER HEALTHCARE LLC, NEW JERSEY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BISEGNA, JOSEPH;NEFF, JARED;SIGNING DATES FROM 20180220 TO 20180606;REEL/FRAME:053200/0899 |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |