US20160374958A1 - Anti-microbial composition comprising cannabinoids - Google Patents

Anti-microbial composition comprising cannabinoids Download PDF

Info

Publication number
US20160374958A1
US20160374958A1 US15/188,143 US201615188143A US2016374958A1 US 20160374958 A1 US20160374958 A1 US 20160374958A1 US 201615188143 A US201615188143 A US 201615188143A US 2016374958 A1 US2016374958 A1 US 2016374958A1
Authority
US
United States
Prior art keywords
weight
microbial
total composition
group
powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US15/188,143
Inventor
George E. Anastassov
Lekhram Changoer
Phillipus Anne Van Damme
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axim Biotechnologies Inc
Original Assignee
Axim Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axim Biotechnologies Inc filed Critical Axim Biotechnologies Inc
Priority to US15/188,143 priority Critical patent/US20160374958A1/en
Assigned to Axim Biotechnologies, Inc. reassignment Axim Biotechnologies, Inc. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: VAN DAMME, Phillipus, ANASTASSOV, George, CHANGOER, Lekhram
Publication of US20160374958A1 publication Critical patent/US20160374958A1/en
Priority to US16/293,136 priority patent/US10441552B2/en
Priority to US16/545,808 priority patent/US11058646B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases

Definitions

  • compositions comprise cannabinoids, specifically cannabigerol and/or cannabidiol, which are non-psychoactive phytocannabinoids.
  • the composition is anti-microbial spray, antibiotic cream, antifungal cream, or anti-microbial liquid.
  • the cannabis plant has many naturally occurring substances that are of great interest in the fields of science and medicine.
  • Isolated compounds from the cannabis plant include ⁇ 9 -tetrahydrocannabinol (THC), cannabidiol (CBD), cannabichromene (CBC), cannabigerol (CBG), cannabinol (CBN), cannabidivarin (CBDV), among other compounds. While THC has psychoactive effects, CBD, CBC, CBG, and CBDV do not.
  • Isolated compounds from the cannabis plant are called cannabinoids. There are a total of eighty-five (85) cannabinoids that have been isolated from the cannabis plant. Many researchers have confirmed the medicinal value of cannabinoids. Cannabinoids have been investigated for possible treatment of seizures, nausea, vomiting, lack of appetite, pain, arthritis, inflammation, and other conditions.
  • Cannabinoids can be isolated by extraction or cold pressing from cannabis plants. Plants in the cannabis genus include Cannabis sativa, Cannabis ruderalis , and Cannabis indica . These plants are the natural sources of cannabinoids. Cannabinoids are also available in synthetic forms. Methods to synthesize cannabinoids in lab settings were discovered and are still currently practiced. Synthetic cannabinoids are more targeted, in that the synthetic compound usually comes isolated without other cannabinoids mixed in.
  • Nabilone (racemic(6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6H-benzo[c]chromen-9(6aH)-one), a synthetic cannabinoid, is believed to have fewer undesired side effects than THC. Nabilone mimics the chemical compound structure of THC. THC also exists in synthetic form under the name Dronabinol (( ⁇ )-(6aR,10aR)-6,6,9-trimythel-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol)).
  • nabilone for treatment of chemotherapy-induced nausea and vomiting. In the United States, nabilone is marketed under the name Cesamet®.
  • THC The IUPAC nomenclature of THC is ( ⁇ )-(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol.
  • CBD's IUPAC nomenclature is 2-((1S,6S)-3-methyl-6-(prop-1-en-2-yl)cyclo-hex-2-enyl)-5-pentylbenzene-1,3-diol).
  • CBC has the IUPAC nomenclature of 2-methyl-2-(4-methylpent-3-enyl)-7pentyl-5-chromenol.
  • CBG has the IUPAC nomenclature of 2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentyl-benzene-1,3-diol. These are among the most prominent compounds in the family of compounds extracted from the cannabis plant referred to as cannabinoids.
  • Cannabidiol is a major phytocannabinoid, accounting for up to 40% of the plant's extract.
  • CBD is a CB-1 receptor antagonist
  • THC is a CB-1 receptor agonist.
  • a 2010 research found that cannabis strains with higher concentration of CBD did not produce the short-term memory impairment normally seen in high THC cannabis strains, a characteristic attributed to the CB-1 receptor antagonist nature of CBD. CBD is considered to have a wider scope of medical applications than THC.
  • CBG cannabigerol
  • Cannabis abuse can occur among chronic users, especially when raw plant materials are consumed by smoking. Collectively, this abuse is referred to as cannabis use disorder. Discontinuance of cannabis consumption can result in withdrawal symptoms. However, some cannabinoids, such as CBD, may be useful in treating cannabis use disorder.
  • Anti-bacterial products are used to kill, repress the growth of, or repress the reproduction of bacteria.
  • topical anti-bacterial products on the market, including soap, hand sanitizer liquid, hand wipes, skin cream, spray, and eye drops.
  • many of these existing products contain triclosan or triclocarban, ingredients criticized for having unanticipated effects on hormones and contributing to bacterial resistance.
  • topical anti-microbial products without triclosan in order to avoid undesirable negative hormonal effects.
  • the anti-microbial product has effects against difficult to treat bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA), as well as viruses and fungi.
  • MRSA Methicillin-resistant Staphylococcus aureus
  • This invention generally relates to anti-microbial compositions comprising cannabinoids for use on human skin and/or nails, and for use on other non-living surfaces in frequent contact with humans.
  • the anti-microbial composition comprises at least one cannabinoid at 2% to 5% by weight of the total composition.
  • Cannabinoids used in this invention are either natural or synthetic.
  • the cannabinoid anti-microbial composition is formulated as a spray, a gel, a cream, or a liquid.
  • an anti-microbial in cream form comprising:
  • the anti-microbial composition in cream form may further comprise a binding agent selected from the group consisting of alginic acid, ammonium alginate, calcium caseinate, calcium sulfate hydrate, polyvinyl acetate, polyacrylic acid, polyisobutylene, potassium alginate, propylene glycol alginate, and polyvinylpyrrolidone at 5% to 20% by weight of the total composition.
  • a binding agent selected from the group consisting of alginic acid, ammonium alginate, calcium caseinate, calcium sulfate hydrate, polyvinyl acetate, polyacrylic acid, polyisobutylene, potassium alginate, propylene glycol alginate, and polyvinylpyrrolidone at 5% to 20% by weight of the total composition.
  • the anti-microbial composition in cream form may further comprise a skin conditioning agent selected from the group consisting of amodimethicone, alkyl benzoate, caprylyl glycol, cetyl palminate, cyclo-dimethicone, dimethicone 500, dimethicone satin, ethylhexyl glycerin, iso-dimethicone copolymer, isododecane, isoeicosane, isolanolin, lanolin alcohol, octyldodecanol, PEG-8 dimethicone, and polyamide 3 at 0.1% to 2% by weight of the total composition.
  • a skin conditioning agent selected from the group consisting of amodimethicone, alkyl benzoate, caprylyl glycol, cetyl palminate, cyclo-dimethicone, dimethicone 500, dimethicone satin, ethylhexyl glycerin, iso-d
  • the anti-microbial composition in cream form may further comprise a fragrance.
  • an anti-microbial in spray form comprising:
  • the anti-microbial in spray form may further comprise a chelating agent present at 0.05% to 0.5% by weight of the total composition selected from the group consisting of disodium gluconate, disodium EDTA, tetrasodium EDTA, and tetrasodium glutamate diacetate.
  • a chelating agent present at 0.05% to 0.5% by weight of the total composition selected from the group consisting of disodium gluconate, disodium EDTA, tetrasodium EDTA, and tetrasodium glutamate diacetate.
  • the anti-microbial in spray form may further comprise a skin conditioning agent present at 0.1% to 2% by weight of the total composition selected from the group consisting of amodimethicone, alkyl benzoate, caprylyl glycol, cetyl palminate, cyclo-dimethicone, dimethicone 500, dimethicone satin, ethylhexyl glycerin, iso-dimethicone copolymer, isododecane, isoeicosane, isolanolin, lanolin alcohol, octyldodecanol, PEG-8 dimethicone, and polyamide 3.
  • a skin conditioning agent present at 0.1% to 2% by weight of the total composition selected from the group consisting of amodimethicone, alkyl benzoate, caprylyl glycol, cetyl palminate, cyclo-dimethicone, dimethicone 500, dimethicone satin, ethylhex
  • the anti-microbial in spray form may further comprise a fragrance.
  • an anti-microbial liquid comprising:
  • an anti-microbial powder comprising:
  • the anti-microbial powder may further comprise:
  • the anti-microbial powder may be packaged in an aerosol can.
  • an anti-microbial composition comprising the steps of:
  • the method make an anti-microbial composition may further comprise the steps of adding a fragrance to the solution and adjusting the solution's pH to 6.
  • the method to make an anti-microbial powder may further comprise the step of removing the alcohol by vacuum.
  • CBD Cannabidiol
  • CBDV Cannabidivarin
  • CBG Cannabigerol
  • MRSA Methicillin-resistant Staphylococcus aureus
  • THC Tetrahydrocannabinol
  • cannabinoid used in this description, claims, and other conjugations is used to mean any compound that interacts with a cannabinoid receptor and other cannabinoid mimetics, including, but not limited to, certain tetrahydropyran analogs ( ⁇ 9 -tetrahydrocannabinol, ⁇ 8 -tetrahydrocannabinol, 6,6,9-trimythel-3-pentyl-6H-dibenzo[b,d]pyran-1-ol, 3-(1,1-dimethylheptyl)-6,6a 7,8,10,10a-hexahydro-1-1 hydroxy-6,6-dimythel-9H-dibezo[b,d]pyran-9-ol, ( ⁇ )-(3S,4S)-7-hydroxy-delta-6-tetrahydrocannabinol-1,1-dimethylheptyl, (+)-(3S,4S)-7-hydroxy- ⁇ -6-tetra
  • cannabidiol refers to cannabidiol and cannabidiol derivatives.
  • cannabidiol is obtained from industrial hemp extract with a trace amount of THC or from cannabis extract using high-CBD cannabis cultivars.
  • cannabigerol refers to cannabigerol and cannabigerol derivatives.
  • cannabigerol is industrial hemp extract with a trace amount of THC or from cannabis extract.
  • the anti-microbial composition may comprise at least one cannabinoid, such as CBD or CBG, or a combination of cannabinoids.
  • cannabinoids suitable for use in this anti-microbial composition may be THC, CBN, CBDV, or THCV, among other cannabinoids.
  • the total amount of cannabinoid in embodiments may be at 2% to 5% by weight of the total composition.
  • Cannabinoids as used in this preferred embodiment may be provided as crystallized cannabinoids in solid form.
  • Solid cannabinoids may be obtained from natural sources by freeze drying and/or heating of cannabis oil or hemp oil.
  • solid cannabinoids may be obtained from synthetic sources. Methods to synthesize cannabinoids are disclosed in Patent Application Publication US2010/0298579 by THC Pharm GmbH and this reference is included herein as a whole.
  • Cannabinoids may also be in oily form, as cannabis oil, hemp oil, or hashish oil. Due to the hydrophobic nature of the oily form, formulations for liquid anti-microbial compositions may face difficulties in distribution and/or shelf life challenges. In emulsion formulation such as anti-microbial gel or cream, oily forms of cannabinoid may be used without difficulties in dispersion. It is contemplated that cannabinoids provided in oily form may be used in the embodiments described herein.
  • Cannabinoids as used in these embodiments may be CBD, CBG, THC, CBDV, THCV, or other molecules within the cannabinoid family.
  • a combination of cannabinoids may be used in these embodiments, such that the total amount of cannabinoids comprises the quantities as described.
  • the anti-microbial composition may be a gel or cream for topical application.
  • the gel or cream may comprise a liquid base, which may comprise a mixture of water and an alcoholic solvent.
  • the liquid base may provide the environment in which various components of the gel or cream may be emulsified.
  • Alcohol may also contribute to anti-microbial activities of the gel or cream as a whole.
  • the alcohol solvent as used in this embodiment may be either ethanol or isopropyl alcohol. A mixture of alcohols may also be used.
  • water may comprise 30% to 50% of the total composition by weight.
  • Alcohol solvent preferably may comprise 20% to 40% of the total composition by weight.
  • the anti-microbial gel or cream may further comprise a humectant to keep the gel or cream from drying out.
  • a suitable humectant for this gel or cream may be selected from the group consisting of glycerin, hyaluronic acid, lacto-ceramide, hydrolyzed keratin protein, and hydrolyzed collagen protein.
  • hydrolyzed keratin protein may be used to promote the growth of nails.
  • the humectant may be present in this anti-microbial gel or cream at 1% to 5% by weight of the total composition.
  • the gel or cream may further comprise an emulsifier to emulsify hydrophobic components such as cannabinoids.
  • a suitable emulsifier for this gel or cream may be selected from the group consisting of PEG 40 hydrogenated castor oil, disodium PEG-4-cocoamido MIPA sulfosuccinate, lauryl glucoside, and sodium lauroamphoacetate.
  • the emulsifier may be present in this anti-microbial gel or cream at 2% to 15% by weight of the total composition.
  • a binding agent may also be used in this formulation to create a smooth emulsion.
  • Suitable binding agents for this gel or cream may be alginic acid, ammonium alginate, calcium caseinate, calcium sulfate hydrate, polyvinyl acetate, polyacrylic acid, polyisobutylene, potassium alginate, propylene glycol alginate, and polyvinylpyrrolidone.
  • Other binding agents suitable for topical cream or gel may also be used.
  • the binding agent may be present at 5% to 20% by weight of the total composition.
  • the gel or cream may further comprise skin conditioning agents to promote a healthy appearance of the skin.
  • skin conditioning agents may be selected from the group consisting of amodimethicone, alkyl benzoate, caprylyl glycol, cetyl palminate, cyclo-dimethicone, dimethicone 500, dimethicone satin, ethylhexyl glycerin, iso-dimethicone copolymer, isododecane, isoeicosane, isolanolin, lanolin alcohol, octyldodecanol, PEG-8 dimethicone, and polyamide 3.
  • Other skin conditioning agents may also be used.
  • the skin conditioning agent may be present at 0.1% to 2% by weight of the total composition.
  • fragrance may be added to the gel or cream.
  • scents may be used as preferred.
  • fragrance may not be used for those who prefer non-fragranced products.
  • the anti-microbial gel or cream may be used for skin application in wounds and skin infections. Alternatively, this anti-microbial gel or cream may be used for treatment of toe nail fungus due to its anti-fungal properties.
  • the anti-microbial composition may be an anti-microbial spray for topical use.
  • This anti-microbial composition may be formulated to become an aerosol upon pump action.
  • This anti-microbial spray may be used on skin or non-living surfaces.
  • the anti-microbial composition may comprise at least one cannabinoid, preferably CBD or CBG, or a combination of cannabinoids.
  • cannabinoids suitable for use in this anti-microbial composition may be THC, CBN, CBDV, or THCV, among other cannabinoids.
  • the total amount of cannabinoid in these embodiments may be at 2% to 5% by weight of the total composition
  • the spray may comprise a liquid base, which may comprise a mixture of water and an alcohol.
  • the liquid base may provide the environment in which various components of the spray may be emulsified. Alcohol may also contribute to anti-microbial activities of the spray as a whole. Alcohol used in these embodiments may be either ethanol or isopropyl alcohol.
  • water may comprise 30% to 50% of the total composition by weight.
  • Alcohol may comprise 30% to 45% of the total composition by weight.
  • the total weight of the liquid base may comprise between 75% and 90% by weight of the total spray composition.
  • the anti-microbial spray may further comprise an emulsifier to effectively blend hydrophobic and hydrophilic components of the spray.
  • a suitable emulsifier for this spray may be selected from the group consisting of PEG 40 hydrogenated castor oil, disodium PEG-4-cocoamido MIPA sulfosuccinate, lauryl glucoside, methyl gluceth-10, and sodium lauroamphoacetate.
  • the emulsifier may be present in this anti-microbial gel or cream at 2% to 15% by weight of the total composition.
  • the anti-microbial spray may further comprise a humectant to maintain the water content in the spray.
  • a suitable humectant for this gel or cream may be selected from the group consisting of glycerin, hyaluronic acid, lacto-ceramide, hydrolyzed keratin protein, and hydrolyzed collagen protein.
  • hydrolyzed keratin protein may be used to promote the growth of nail growth.
  • the humectant may be present in this anti-microbial spray at 1% to 5% by weight of the total composition.
  • a chelating agent may be added into this anti-microbial spray to preserve stability and efficacy of the spray.
  • Suitable chelating agents may be disodium gluconate, disodium EDTA, tetrasodium EDTA, tetrasodium glutamate diacetate, among other suitable chelating agents.
  • the chelating agent is present in the anti-microbial spray at 0.05% to 0.5% by weight of the total spray composition.
  • the anti-microbial spray may further comprise skin conditioning agents to promote a healthy appearance of the skin.
  • skin conditioning agents may be selected from the group consisting of amodimethicone, alkyl benzoate, caprylyl glycol, cetyl palminate, cyclo-dimethicone, dimethicone 500, dimethicone satin, ethylhexyl glycerin, iso-dimethicone copolymer, isododecane, isoeicosane, isolanolin, lanolin alcohol, octyldodecanol, PEG-8 dimethicone, and polyamide 3.
  • Other skin conditioning agents may also be used.
  • the skin conditioning agent may be present at 0.1% to 2% by weight of the total composition.
  • fragrance may be added. Fragrances with various scents may be used as preferred. Alternatively, fragrance may not be used for non-fragrance products.
  • the anti-microbial spray composition may be used to treat skin infections, including infections from wounds, infections from bacteria, and infections from fungus.
  • This anti-microbial spray may be used on skin as well as nail surfaces where the infection site may be present.
  • the anti-microbial spray may also be used to spray non-living surfaces, including furniture, walls, and door surfaces.
  • the anti-microbial composition may be a liquid comprising cannabinoids that may be used as a hand cleaner liquid, incorporated into wet wipes for anti-microbial purposes, or used as a cleaning liquid for disinfection.
  • the anti-microbial liquid comprises a liquid base, which comprises water and alcohol, wherein other ingredients may be dissolved.
  • Water may comprise between 35% and 55% of the total anti-microbial liquid composition.
  • Alcohol may comprise between 30% and 45% of the total anti-microbial liquid composition.
  • Alcohols suitable for use in this embodiment may be ethanol and isopropyl alcohol.
  • Cannabinoids may be present in this anti-microbial liquid at 5% to 10% by weight of the total anti-microbial liquid. At least one cannabinoid may be used, but a combination of cannabinoids may also be effective.
  • the anti-microbial liquid according to this embodiment may further comprise a surfactant.
  • Surfactants may act to reduce surface tension in the liquid and enable easy emulsifying of the mixture as a whole.
  • Suitable surfactants may be sodium lauryl sulfate, ammonium lauryl sulfate, sodium laureth sulfate, and sodium myreth sulfate, among others.
  • the surfactant may be present in this embodiment at 3% to 10% by weight of the total anti-microbial liquid composition.
  • the cannabinoid anti-microbial liquid may be applied to human skin to kill bacteria.
  • this liquid may be applied to non-living surfaces such as furniture surfaces, walls, doors and door knobs, etc. to disinfect.
  • This liquid may be useful in high-risk environments, such as hospitals or cruise ships.
  • cannabinoids may be provided in solid form and dissolved into an alcohol to form the alcohol phase.
  • Other hydrophilic components may be dissolved into water to form the water phase; then the two phases may be combined and stirred.
  • cannabinoids may be dissolved in an alcohol solvent.
  • Other components such as emulsifiers, humectants, chelating agents, binding agents, skin conditioning agents may be added into the alcohol solution and stirred. Lastly, water may be added and stirred until uniform. The emulsion's pH may be adjusted to 6.
  • the anti-microbial composition may be a powder.
  • the anti-microbial powder may be formulated in a spray or in powder form to be directly applied on to the skin. This anti-microbial powder may be used on skin to treat various bacterial, viral, and fungal infections.
  • the anti-microbial powder may comprise at least one cannabinoid, preferably CBG, CBD, THC, CBDV, or THCV but any other cannabinoid or a combination of cannabinoids may be used.
  • Cannabinoids may be present in this embodiment preferable at 2% to 10% by weight of the total composition.
  • Cannabinoids as used in this embodiment may be in powder form.
  • the anti-microbial powder may further comprise a base powder, such as a mixture of talc and hydrated silica.
  • the base powder may comprise 30% to 90% by weight of the total composition.
  • an alcohol solvent may be used to facilitate the distribution of cannabinoids in this base powder.
  • Alcohol may be present in this preferred embodiment at 5% to 30% by weight of the total composition.
  • the alcohol solvent may be ethanol or isopropyl alcohol.
  • Cannabinoids in powder form may be dissolved into the alcohol solvent and stirred until homogenous.
  • Preservatives, fragrance, and emollients may be added into the cannabinoid-alcohol solution.
  • Suitable preservatives may be butylhydroxytoluene, phenoxyethanol, paraben, and potassium sorbate. Preservatives may be present in this composition at 0.2% to 1.5% by weight.
  • Suitable emollients are dimethyl polysiloxilane, isopropyl myristate, amodimethicone, cetyl palmitate, cyclomethicone, dimethicone 500, isododecane, among other suitable emollients.
  • Emollients may be present at 3% to 20% by weight of the total composition.
  • the base powder may be mixed.
  • Cannabinoid may be dissolved into alcohol, then other components, such as preservatives and emollients, may be added and stirred until clear.
  • the alcohol-cannabinoid solution may then be added into the shear mixer for further mixing. Once the powder in the shear mixer is homogenous, it may be used for further formulation and/or packaging.
  • the anti-microbial powder may be an aerosol spray.
  • the powder mixed by the shear mixer as above may be added into an aerosol can at 5% to 15% by total volume of the can.
  • a propellant solvent selected from the group consisting of butane, isobutane, propane, pentane, and dimethyl ether may be added to the can to make up approximately 100% of the can volume.
  • the propellant may be present at 20% to 70% by weight of the total composition in the aerosol can.
  • the aerosol spray may be used by activating the pump to spray the content to the skin or any surfaces.
  • the anti-microbial powder may be a powder for direct application to the infectious site.
  • the cannabinoid powder from the shear mixer may be dried under vacuum at 60° C. until ethanol evaporates from the powder.
  • the powder may be filled into sachets or containers and may be used for direct application to mammal skin and left for at least 3 minutes.
  • this cannabinoid anti-microbial composition may be used to treat toe nail fungus, MRSA infection, herpes virus infection, tinea pedis, burn wound infections, sun burns, diabetic infections, eczema, impetigo, dermatophytosis, psoriasis, itchy skin, atopic dermatitis, dandruff, and general topical infections on human skin.
  • the cannabinoid anti-microbial composition may be applied to the infected site in therapeutically effective amounts and left on the skin for at least 3 minutes.
  • the cannabinoid anti-microbial composition may also be used to disinfect any surface.
  • An effective amount of the cannabinoid anti-microbial composition may be applied to a surface and left on the surface for at least 3 minutes.
  • Anti-microbial Spray Ingredients Percentage Water 45.600 Ethanol 40.000 CBG (solid) 5.000 PEG 40 hydrogenated castor oil 5.000 Glycerin 3.000 Disodium gluconate 0.200 Methyl gluceth-10 0.200 Ethylhexyl glycerin/phenoxyethanol 0.500 Fragrance 0.500 NaOH (pH adjustment) qs Total 100.00
  • Anti-microbial Cream Ingredients Percentage Water 44.000 Ethanol 30.000 CBG 5.000 PEG 40 hydrogenated castor oil 7.000 Glycerin 3.000 Polyvinylpyrrolidone 10.000 Ethylhexyl glycerin/phenoxyethanol 0.500 Fragrance 0.500 NaOH qs Total 100.00
  • Ingredients are obtained according to the above percentage. Dissolve polyvinylpyrrolidonce in water to form the water phase and set aside. Dissolve CBG in ethanol and stir until the solution is clear, add PEG 40 to form the ethanol phase and stir until the solution is clear. Add the water and ethanol phases together, then add glycerin and stir until the solution is clear. Add ethylhexyl glycerin/phenoxyethanol and stir until the solution is clear. Add fragrance as needed and stir until clear, then adjust pH to 6.
  • Anti-microbial Liquid Ingredients Percentage Aqua 48.000 Sodium lauryl sulphate 5.000 Ethanol 40.000 CBG 7.000 Total 100.000
  • Anti-microbial Powder Ingredients Percentage Hydrated silica 30 Talc 44 Butylhydroxytoluene 0.5 Dimethyl polysiloxilane 5 Isopropyl myristate 5 Fragrance 0.5 Ethanol 10 CBG 5 Total 100
  • the powder mixture from the shear mixer may be added into an aerosol can at 10% volume of the can.
  • Add propane to fill the aerosol can, and the aerosol cannabinoid powder may be applied to infection sites.
  • powder from the shear mixer is dried under vacuum at 60° C. to evaporate the ethanol.
  • the cannabinoid antibacterial powder may be used to apply to infection sites.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Botany (AREA)

Abstract

This invention discloses anti-bacterial and anti-fungal compositions in spray form, in cream form, in liquid form, and in powder form. The anti-bacterial and anti-fungal compositions comprise cannabinoids, specifically cannabidiol, cannabigerol, tetrahydrocannabinol, tetracannabidivarin, and/or cannabidivarin for anti-bacterial and anti-fungal activities. The anti-bacterial and anti-fungal compositions may be used to treat toe nail fungus, MRSA infection, herpes virus infection, tinea pedis, burn wound infections, sun burns, diabetic infections, eczema, impetigo, dermatophytosis, psoriasis, itchy skin, atopic dermatitis, dandruff, and general topical infections.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application claims the benefit of U.S. Provisional Application No. 62/183,357, filed Jun. 23, 2015, the content of which is incorporated by reference in its entirety.
    • BACKGROUND OF THE INVENTION
  • Field of the Invention
  • This invention relates to anti-microbial, in particular anti-bacterial and anti-fungal compositions and the topical application of such compositions for the prevention and/or treatment of bacterial and fungal infections on the skin. The compositions comprise cannabinoids, specifically cannabigerol and/or cannabidiol, which are non-psychoactive phytocannabinoids. The composition is anti-microbial spray, antibiotic cream, antifungal cream, or anti-microbial liquid.
  • Description of the Related Technology
  • The cannabis plant has many naturally occurring substances that are of great interest in the fields of science and medicine. Isolated compounds from the cannabis plant include Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabichromene (CBC), cannabigerol (CBG), cannabinol (CBN), cannabidivarin (CBDV), among other compounds. While THC has psychoactive effects, CBD, CBC, CBG, and CBDV do not. Isolated compounds from the cannabis plant are called cannabinoids. There are a total of eighty-five (85) cannabinoids that have been isolated from the cannabis plant. Many researchers have confirmed the medicinal value of cannabinoids. Cannabinoids have been investigated for possible treatment of seizures, nausea, vomiting, lack of appetite, pain, arthritis, inflammation, and other conditions.
  • Cannabinoids can be isolated by extraction or cold pressing from cannabis plants. Plants in the cannabis genus include Cannabis sativa, Cannabis ruderalis, and Cannabis indica. These plants are the natural sources of cannabinoids. Cannabinoids are also available in synthetic forms. Methods to synthesize cannabinoids in lab settings were discovered and are still currently practiced. Synthetic cannabinoids are more targeted, in that the synthetic compound usually comes isolated without other cannabinoids mixed in.
  • Nabilone (racemic(6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6H-benzo[c]chromen-9(6aH)-one), a synthetic cannabinoid, is believed to have fewer undesired side effects than THC. Nabilone mimics the chemical compound structure of THC. THC also exists in synthetic form under the name Dronabinol ((−)-(6aR,10aR)-6,6,9-trimythel-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol)). These synthetic cannabinoids are sold for food supplement purposes and are being investigated for medicinal purposes. The U.S. Food and Drug Administration approved nabilone for treatment of chemotherapy-induced nausea and vomiting. In the United States, nabilone is marketed under the name Cesamet®.
  • The IUPAC nomenclature of THC is (−)-(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol. CBD's IUPAC nomenclature is 2-((1S,6S)-3-methyl-6-(prop-1-en-2-yl)cyclo-hex-2-enyl)-5-pentylbenzene-1,3-diol). CBC has the IUPAC nomenclature of 2-methyl-2-(4-methylpent-3-enyl)-7pentyl-5-chromenol. CBG has the IUPAC nomenclature of 2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentyl-benzene-1,3-diol. These are among the most prominent compounds in the family of compounds extracted from the cannabis plant referred to as cannabinoids.
  • Cannabidiol is a major phytocannabinoid, accounting for up to 40% of the plant's extract. CBD is a CB-1 receptor antagonist, while THC is a CB-1 receptor agonist. A 2010 research found that cannabis strains with higher concentration of CBD did not produce the short-term memory impairment normally seen in high THC cannabis strains, a characteristic attributed to the CB-1 receptor antagonist nature of CBD. CBD is considered to have a wider scope of medical applications than THC.
  • Because it is a relatively unknown cannabinoid, cannabigerol (CBG) remains understudied and its effects are only just starting to become clear. CBG is a non-psychoactive cannabinoid found in the cannabis plant. All cannabinoids in the early stage of the cannabis plant's life begins as CBG. CBG is found in higher concentrations in hemp plants as opposed to marijuana plants, which are grown to have higher concentrations of tetrahydrocannabinol (THC). CBG has been found to act as a high affinity α2-adrenergic receptor agonist, a moderate affinity 5-HT1A receptor antagonist, and a low affinity CB1 receptor antagonist. It binds with the CB2 receptor, but it is currently unknown whether it acts as an agonist or antagonist.
  • Cannabis abuse can occur among chronic users, especially when raw plant materials are consumed by smoking. Collectively, this abuse is referred to as cannabis use disorder. Discontinuance of cannabis consumption can result in withdrawal symptoms. However, some cannabinoids, such as CBD, may be useful in treating cannabis use disorder.
  • Anti-bacterial products are used to kill, repress the growth of, or repress the reproduction of bacteria. There are a number of topical anti-bacterial products on the market, including soap, hand sanitizer liquid, hand wipes, skin cream, spray, and eye drops. However, many of these existing products contain triclosan or triclocarban, ingredients criticized for having unanticipated effects on hormones and contributing to bacterial resistance. There is a demand for topical anti-microbial products without triclosan in order to avoid undesirable negative hormonal effects. The anti-microbial product has effects against difficult to treat bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA), as well as viruses and fungi.
    • SUMMARY
  • This invention generally relates to anti-microbial compositions comprising cannabinoids for use on human skin and/or nails, and for use on other non-living surfaces in frequent contact with humans. The anti-microbial composition comprises at least one cannabinoid at 2% to 5% by weight of the total composition. Cannabinoids used in this invention are either natural or synthetic. The cannabinoid anti-microbial composition is formulated as a spray, a gel, a cream, or a liquid.
  • In this invention, there is provided an anti-microbial in cream form comprising:
      • at least one cannabinoid at 2% to 5% by weight of the total composition selected from the group consisting of cannabidiol, cannabigerol, tetrahydrocannabinol, cannabidivarin, and tetrahydrocannabivarin;
      • at least one alcoholic solvent at 20% to 40% by weight of the total composition selected from the group consisting of ethanol and isopropyl alcohol;
      • a humectant at 1% to 5% by weight of the total composition selected from the group consisting of glycerin, hyaluronic acid, lacto-ceramide, hydrolyzed keratin protein, and hydrolyzed collagen protein;
      • an emulsifier at 2% to 15% by weight of the total composition selected from the group consisting of PEG 40 hydrogenated castor oil, disodium PEG-4-cocoamido MIPA sulfosuccinate, lauryl glucoside, and sodium lauroamphoacetate; and
      • water at 30% to 50% by weight of the total composition.
  • The anti-microbial composition in cream form may further comprise a binding agent selected from the group consisting of alginic acid, ammonium alginate, calcium caseinate, calcium sulfate hydrate, polyvinyl acetate, polyacrylic acid, polyisobutylene, potassium alginate, propylene glycol alginate, and polyvinylpyrrolidone at 5% to 20% by weight of the total composition.
  • The anti-microbial composition in cream form may further comprise a skin conditioning agent selected from the group consisting of amodimethicone, alkyl benzoate, caprylyl glycol, cetyl palminate, cyclo-dimethicone, dimethicone 500, dimethicone satin, ethylhexyl glycerin, iso-dimethicone copolymer, isododecane, isoeicosane, isolanolin, lanolin alcohol, octyldodecanol, PEG-8 dimethicone, and polyamide 3 at 0.1% to 2% by weight of the total composition.
  • The anti-microbial composition in cream form may further comprise a fragrance.
  • In this invention, there is provided an anti-microbial in spray form comprising:
      • at least one cannabinoid at 2% to 5% by weight of the total composition selected from the group consisting of cannabidiol, cannabigerol, tetrahydrocannabinol, cannabidivarin, and tetrahydrocannabivarin;
      • a humectant at 1% to 5% by weight of the total composition selected from the group consisting of glycerin, hyaluronic acid, lacto-ceramide, hydrolyzed keratin protein, and hydrolyzed collagen protein;
      • an emulsifier at 2% to 15% by weight of the total composition selected from the group consisting of PEG 40 hydrogenated castor oil, disodium PEG-4-cocoamido MIPA sulfosuccinate, lauryl glucoside, methyl gluceth-10, and sodium lauroamphoacetate;
      • at least one alcohol at 30% to 45% by weight of the total composition selected from the group consisting of ethanol and isopropyl alcohol; and
      • water at 30% to 50% by weight of the total composition.
  • The anti-microbial in spray form may further comprise a chelating agent present at 0.05% to 0.5% by weight of the total composition selected from the group consisting of disodium gluconate, disodium EDTA, tetrasodium EDTA, and tetrasodium glutamate diacetate.
  • The anti-microbial in spray form may further comprise a skin conditioning agent present at 0.1% to 2% by weight of the total composition selected from the group consisting of amodimethicone, alkyl benzoate, caprylyl glycol, cetyl palminate, cyclo-dimethicone, dimethicone 500, dimethicone satin, ethylhexyl glycerin, iso-dimethicone copolymer, isododecane, isoeicosane, isolanolin, lanolin alcohol, octyldodecanol, PEG-8 dimethicone, and polyamide 3.
  • The anti-microbial in spray form may further comprise a fragrance.
  • In this invention, there is provided an anti-microbial liquid comprising:
      • at least one cannabinoid at 5% to 10% by weight of the total composition selected from the group consisting of cannabidiol, cannabigerol, tetrahydrocannabinol, cannabidivarin, and tetrahydrocannabivarin;
      • a surfactant at 3% to 10% by weight of the total composition selected from the group consisting of sodium lauryl sulfate, ammonium lauryl sulfate, sodium laureth sulfate, and sodium myreth sulfate;
      • at least one alcohol at 30% to 45% by weight of the total composition selected from the group consisting of ethanol or isopropyl alcohol; and
      • water at 35% to 55% by weight of the total composition.
  • In this invention, there is provided an anti-microbial powder comprising:
      • at least one cannabinoid at 5% to 10% by weight of the total composition selected from the group consisting of cannabidiol, cannabigerol, tetrahydrocannabinol, cannabidivarin, and tetrahydrocannabivarin;
      • at least one preservative at 0.2% to 1.5% by weight of the total composition selected from the group consisting of butylhydroxytoluene, phenoxyethanol, paraben, and potassium sorbate;
      • at least one emollient at 3% to 20% by weight of the total composition selected from the group consisting of dimethyl polysiloxilane, isopropyl myristate, amodimethicone, cetyl palmitate, cyclomethicone, dimethicone 500, and isododecane; and
      • a powder comprising talc and hydrated silica at 20% to 90% by weight of the total composition.
  • The anti-microbial powder may further comprise:
      • at least one alcohol at 20% to 80% by weight of the total composition selected from the group consisting of ethanol and isopropyl alcohol; and
      • at least one propellant solvent at 20% to 70% by weight of the total composition selected from the group consisting of butane, isobutane, propane, pentane, and dimethyl ether.
  • The anti-microbial powder may be packaged in an aerosol can.
  • In this invention, there is further provided a method to make an anti-microbial composition comprising the steps of:
      • dissolving at least one solid cannabinoid into an alcohol to form a solution;
      • adding at least one of an emulsifier, a humectant, a chelating agent, a binding agent, or a skin conditioning agent to the solution;
      • stirring the solution;
      • adding water to the solution; and
      • stirring the solution.
  • The method make an anti-microbial composition may further comprise the steps of adding a fragrance to the solution and adjusting the solution's pH to 6.
  • In this invention, there is further provided a method to make an anti-microbial powder comprising the steps of:
      • dissolving at least one solid cannabinoid into an alcohol to form a solution;
      • adding at least one emollient and at least one preservative into the solution from the first step;
      • adding the solution from the second step into a powder comprising talc and hydrated silica to form a powder;
      • mixing the powder mixture in a shear mixer;
      • adding the powder into an aerosol can; and
      • adding at least one propellant selected from the group consisting of butane, isobutane, propane, pentane, and dimethyl ether.
  • The method to make an anti-microbial powder may further comprise the step of removing the alcohol by vacuum.
  • In this invention, there is further provided a method to disinfect a surface comprising the steps of:
      • applying an effective amount of a composition according to claim 1 to a surface; and
      • leaving the composition on the surface for at least 3 minutes,
      • wherein the surface is either mammal skin or non-living surfaces.
  • In this invention, there is further provided a method to treat an infection on mammal skin comprising the steps of:
      • applying an therapeutically effective amount of a composition according to claim 1 to the skin; and
      • leaving the composition on the skin for at least 3 minutes,
      • wherein the infection is selected from the group consisting of toe nail fungus, MRSA infection, herpes virus infection, tinea pedis, burn wound infections, sun burns, diabetic infections, eczema, impetigo, dermatophytosis, psoriasis, itchy skin, atopic dermatitis, dandruff, and general topical infections.
    ABBREVIATIONS
  • CBC: Cannabichromene
  • CBD: Cannabidiol
  • CBDV: Cannabidivarin
  • CBG: Cannabigerol
  • CBN: Cannabinol
  • EDTA: Ethylenediaminetetraacetic acid
  • IUPAC: International Union of Pure and Applied Chemistry
  • MRSA: Methicillin-resistant Staphylococcus aureus
  • PEG: Polyethylene glycol
  • THC: Tetrahydrocannabinol
  • THCV: Tetrahydrocannabidivarin
    • DETAILED DESCRIPTION OF CERTAIN INVENTIVE EMBODIMENTS
  • This present invention is capable of being embodied in various forms. The description below of several embodiments is made with the understanding that the present disclosure is to be considered as an exemplification of the claimed subject matter, and is not intended to limit the attached claims to the specific embodiments illustrated. The headings used throughout this disclosure are provided for convenience only and are not to be construed to limit the claims in any way. Embodiments illustrated under any heading may be combined with embodiments illustrated under any other heading.
  • As used herein, the verb “to comprise” in this description, claims, and other conjugations are used in their non-limiting sense to mean those items following the word are included, but items not specifically mentioned are not excluded.
  • Reference to an element by the indefinite article “a” or “an” does not exclude the possibility that more than one of the elements are present, unless the context clearly requires that there is one and only one of the elements. The indefinite article “a” or “an” thus usually means “at least one.” Additionally, the words “a” and “an” when used in the present document in concert with the words “comprising” or “containing” denote “one or more.”
  • The word “cannabinoid” used in this description, claims, and other conjugations is used to mean any compound that interacts with a cannabinoid receptor and other cannabinoid mimetics, including, but not limited to, certain tetrahydropyran analogs (Δ9-tetrahydrocannabinol, Δ8-tetrahydrocannabinol, 6,6,9-trimythel-3-pentyl-6H-dibenzo[b,d]pyran-1-ol, 3-(1,1-dimethylheptyl)-6,6a 7,8,10,10a-hexahydro-1-1 hydroxy-6,6-dimythel-9H-dibezo[b,d]pyran-9-ol, (−)-(3S,4S)-7-hydroxy-delta-6-tetrahydrocannabinol-1,1-dimethylheptyl, (+)-(3S,4S)-7-hydroxy-Δ-6-tetrahydrocannabinol, and Δ8-tetrahydrocannabinol-1,1-oic acid); certain piperidine analogs (e.g., (−)-(6S,6aR,9R,10aR)-5,6,6a,7,8,9,10,10a-octahydro-6-methyl-1-3-[(R)-1-methyl-4-phenylbutoxy]-1,9-phenanthridinediol 1-acetate)); certain aminoalkylindole analogs (e.g., (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylm-ethyl)-pyrrolo[1,2,3,-de]-1,4-benzoxazin-6-yl]-1-naphthelenyl-methanone); certain open pyran-ring analogs (e.g., 2-[3-methyl-6-(1-methylethenyl-2-cyclohexen-1-yl]-5-pentyl-1,3-benzendi-ol, and 4-(1,1-dimethylheptyl)-2,3′-dihydroxy-6′-α-(3-hydroxypropyl)-1′-2′,3′,4′,5′,6′-hexahydrobiphenyl), their salts, solvates, metabolites, and metabolic precursors.
  • The word “cannabidiol” refers to cannabidiol and cannabidiol derivatives. As used in this application, cannabidiol is obtained from industrial hemp extract with a trace amount of THC or from cannabis extract using high-CBD cannabis cultivars.
  • The word “cannabigerol” refers to cannabigerol and cannabigerol derivatives. As used in this application, cannabigerol is industrial hemp extract with a trace amount of THC or from cannabis extract.
  • In embodiments, the anti-microbial composition may comprise at least one cannabinoid, such as CBD or CBG, or a combination of cannabinoids. Other cannabinoids suitable for use in this anti-microbial composition may be THC, CBN, CBDV, or THCV, among other cannabinoids. The total amount of cannabinoid in embodiments may be at 2% to 5% by weight of the total composition.
  • Cannabinoids as used in this preferred embodiment may be provided as crystallized cannabinoids in solid form. Solid cannabinoids may be obtained from natural sources by freeze drying and/or heating of cannabis oil or hemp oil. Alternatively, solid cannabinoids may be obtained from synthetic sources. Methods to synthesize cannabinoids are disclosed in Patent Application Publication US2010/0298579 by THC Pharm GmbH and this reference is included herein as a whole.
  • Cannabinoids may also be in oily form, as cannabis oil, hemp oil, or hashish oil. Due to the hydrophobic nature of the oily form, formulations for liquid anti-microbial compositions may face difficulties in distribution and/or shelf life challenges. In emulsion formulation such as anti-microbial gel or cream, oily forms of cannabinoid may be used without difficulties in dispersion. It is contemplated that cannabinoids provided in oily form may be used in the embodiments described herein.
  • Cannabinoids as used in these embodiments may be CBD, CBG, THC, CBDV, THCV, or other molecules within the cannabinoid family. A combination of cannabinoids may be used in these embodiments, such that the total amount of cannabinoids comprises the quantities as described.
  • In embodiments, the anti-microbial composition may be a gel or cream for topical application. Apart from at least one cannabinoid, the gel or cream may comprise a liquid base, which may comprise a mixture of water and an alcoholic solvent. The liquid base may provide the environment in which various components of the gel or cream may be emulsified. Alcohol may also contribute to anti-microbial activities of the gel or cream as a whole. The alcohol solvent as used in this embodiment may be either ethanol or isopropyl alcohol. A mixture of alcohols may also be used.
  • In these embodiments, water may comprise 30% to 50% of the total composition by weight. Alcohol solvent preferably may comprise 20% to 40% of the total composition by weight.
  • The anti-microbial gel or cream may further comprise a humectant to keep the gel or cream from drying out. A suitable humectant for this gel or cream may be selected from the group consisting of glycerin, hyaluronic acid, lacto-ceramide, hydrolyzed keratin protein, and hydrolyzed collagen protein. When the gel or cream is used on nails, hydrolyzed keratin protein may be used to promote the growth of nails. The humectant may be present in this anti-microbial gel or cream at 1% to 5% by weight of the total composition.
  • The gel or cream may further comprise an emulsifier to emulsify hydrophobic components such as cannabinoids. A suitable emulsifier for this gel or cream may be selected from the group consisting of PEG 40 hydrogenated castor oil, disodium PEG-4-cocoamido MIPA sulfosuccinate, lauryl glucoside, and sodium lauroamphoacetate. The emulsifier may be present in this anti-microbial gel or cream at 2% to 15% by weight of the total composition.
  • A binding agent may also be used in this formulation to create a smooth emulsion. Suitable binding agents for this gel or cream may be alginic acid, ammonium alginate, calcium caseinate, calcium sulfate hydrate, polyvinyl acetate, polyacrylic acid, polyisobutylene, potassium alginate, propylene glycol alginate, and polyvinylpyrrolidone. Other binding agents suitable for topical cream or gel may also be used. The binding agent may be present at 5% to 20% by weight of the total composition.
  • The gel or cream may further comprise skin conditioning agents to promote a healthy appearance of the skin. Suitable skin conditioning agents may be selected from the group consisting of amodimethicone, alkyl benzoate, caprylyl glycol, cetyl palminate, cyclo-dimethicone, dimethicone 500, dimethicone satin, ethylhexyl glycerin, iso-dimethicone copolymer, isododecane, isoeicosane, isolanolin, lanolin alcohol, octyldodecanol, PEG-8 dimethicone, and polyamide 3. Other skin conditioning agents may also be used. The skin conditioning agent may be present at 0.1% to 2% by weight of the total composition.
  • To enhance aesthetic appeal, fragrance may be added to the gel or cream. Various scents may be used as preferred. Alternatively, fragrance may not be used for those who prefer non-fragranced products.
  • The anti-microbial gel or cream may be used for skin application in wounds and skin infections. Alternatively, this anti-microbial gel or cream may be used for treatment of toe nail fungus due to its anti-fungal properties.
  • In other embodiments, the anti-microbial composition may be an anti-microbial spray for topical use. This anti-microbial composition may be formulated to become an aerosol upon pump action. This anti-microbial spray may be used on skin or non-living surfaces.
  • In these embodiments, the anti-microbial composition may comprise at least one cannabinoid, preferably CBD or CBG, or a combination of cannabinoids. Other cannabinoids suitable for use in this anti-microbial composition may be THC, CBN, CBDV, or THCV, among other cannabinoids. The total amount of cannabinoid in these embodiments may be at 2% to 5% by weight of the total composition
  • Apart from at least one cannabinoid, the spray may comprise a liquid base, which may comprise a mixture of water and an alcohol. The liquid base may provide the environment in which various components of the spray may be emulsified. Alcohol may also contribute to anti-microbial activities of the spray as a whole. Alcohol used in these embodiments may be either ethanol or isopropyl alcohol.
  • In these embodiments, water may comprise 30% to 50% of the total composition by weight. Alcohol may comprise 30% to 45% of the total composition by weight. The total weight of the liquid base may comprise between 75% and 90% by weight of the total spray composition.
  • The anti-microbial spray may further comprise an emulsifier to effectively blend hydrophobic and hydrophilic components of the spray. A suitable emulsifier for this spray may be selected from the group consisting of PEG 40 hydrogenated castor oil, disodium PEG-4-cocoamido MIPA sulfosuccinate, lauryl glucoside, methyl gluceth-10, and sodium lauroamphoacetate. The emulsifier may be present in this anti-microbial gel or cream at 2% to 15% by weight of the total composition.
  • The anti-microbial spray may further comprise a humectant to maintain the water content in the spray. A suitable humectant for this gel or cream may be selected from the group consisting of glycerin, hyaluronic acid, lacto-ceramide, hydrolyzed keratin protein, and hydrolyzed collagen protein. When the anti-microbial spray is used on nails, hydrolyzed keratin protein may be used to promote the growth of nail growth. The humectant may be present in this anti-microbial spray at 1% to 5% by weight of the total composition.
  • A chelating agent may be added into this anti-microbial spray to preserve stability and efficacy of the spray. Suitable chelating agents may be disodium gluconate, disodium EDTA, tetrasodium EDTA, tetrasodium glutamate diacetate, among other suitable chelating agents. The chelating agent is present in the anti-microbial spray at 0.05% to 0.5% by weight of the total spray composition.
  • The anti-microbial spray may further comprise skin conditioning agents to promote a healthy appearance of the skin. Suitable skin conditioning agents may be selected from the group consisting of amodimethicone, alkyl benzoate, caprylyl glycol, cetyl palminate, cyclo-dimethicone, dimethicone 500, dimethicone satin, ethylhexyl glycerin, iso-dimethicone copolymer, isododecane, isoeicosane, isolanolin, lanolin alcohol, octyldodecanol, PEG-8 dimethicone, and polyamide 3. Other skin conditioning agents may also be used. The skin conditioning agent may be present at 0.1% to 2% by weight of the total composition.
  • To enhance aesthetic appeal of the spray, fragrance may be added. Fragrances with various scents may be used as preferred. Alternatively, fragrance may not be used for non-fragrance products.
  • The anti-microbial spray composition may be used to treat skin infections, including infections from wounds, infections from bacteria, and infections from fungus. This anti-microbial spray may be used on skin as well as nail surfaces where the infection site may be present. Moreover, the anti-microbial spray may also be used to spray non-living surfaces, including furniture, walls, and door surfaces.
  • In another preferred embodiment, the anti-microbial composition may be a liquid comprising cannabinoids that may be used as a hand cleaner liquid, incorporated into wet wipes for anti-microbial purposes, or used as a cleaning liquid for disinfection.
  • In this preferred embodiment, the anti-microbial liquid comprises a liquid base, which comprises water and alcohol, wherein other ingredients may be dissolved. Water may comprise between 35% and 55% of the total anti-microbial liquid composition. Alcohol may comprise between 30% and 45% of the total anti-microbial liquid composition. Alcohols suitable for use in this embodiment may be ethanol and isopropyl alcohol.
  • Cannabinoids may be present in this anti-microbial liquid at 5% to 10% by weight of the total anti-microbial liquid. At least one cannabinoid may be used, but a combination of cannabinoids may also be effective.
  • The anti-microbial liquid according to this embodiment may further comprise a surfactant. Surfactants may act to reduce surface tension in the liquid and enable easy emulsifying of the mixture as a whole. Suitable surfactants may be sodium lauryl sulfate, ammonium lauryl sulfate, sodium laureth sulfate, and sodium myreth sulfate, among others. The surfactant may be present in this embodiment at 3% to 10% by weight of the total anti-microbial liquid composition.
  • The cannabinoid anti-microbial liquid may be applied to human skin to kill bacteria. Alternatively, this liquid may be applied to non-living surfaces such as furniture surfaces, walls, doors and door knobs, etc. to disinfect. This liquid may be useful in high-risk environments, such as hospitals or cruise ships.
  • In embodiments, cannabinoids may be provided in solid form and dissolved into an alcohol to form the alcohol phase. Other hydrophilic components may be dissolved into water to form the water phase; then the two phases may be combined and stirred.
  • Alternatively, cannabinoids may be dissolved in an alcohol solvent. Other components such as emulsifiers, humectants, chelating agents, binding agents, skin conditioning agents may be added into the alcohol solution and stirred. Lastly, water may be added and stirred until uniform. The emulsion's pH may be adjusted to 6.
  • In another preferred embodiment, the anti-microbial composition may be a powder. The anti-microbial powder may be formulated in a spray or in powder form to be directly applied on to the skin. This anti-microbial powder may be used on skin to treat various bacterial, viral, and fungal infections.
  • In this preferred embodiment, the anti-microbial powder may comprise at least one cannabinoid, preferably CBG, CBD, THC, CBDV, or THCV but any other cannabinoid or a combination of cannabinoids may be used. Cannabinoids may be present in this embodiment preferable at 2% to 10% by weight of the total composition. Cannabinoids as used in this embodiment may be in powder form.
  • The anti-microbial powder may further comprise a base powder, such as a mixture of talc and hydrated silica. The base powder may comprise 30% to 90% by weight of the total composition. To facilitate the distribution of cannabinoids in this base powder, an alcohol solvent may be used.
  • Alcohol may be present in this preferred embodiment at 5% to 30% by weight of the total composition. The alcohol solvent may be ethanol or isopropyl alcohol. Cannabinoids in powder form may be dissolved into the alcohol solvent and stirred until homogenous. Preservatives, fragrance, and emollients may be added into the cannabinoid-alcohol solution.
  • Suitable preservatives may be butylhydroxytoluene, phenoxyethanol, paraben, and potassium sorbate. Preservatives may be present in this composition at 0.2% to 1.5% by weight. Suitable emollients are dimethyl polysiloxilane, isopropyl myristate, amodimethicone, cetyl palmitate, cyclomethicone, dimethicone 500, isododecane, among other suitable emollients. Emollients may be present at 3% to 20% by weight of the total composition.
  • In a shear mixer, the base powder may be mixed. Cannabinoid may be dissolved into alcohol, then other components, such as preservatives and emollients, may be added and stirred until clear. The alcohol-cannabinoid solution may then be added into the shear mixer for further mixing. Once the powder in the shear mixer is homogenous, it may be used for further formulation and/or packaging.
  • In an embodiment, the anti-microbial powder may be an aerosol spray. The powder mixed by the shear mixer as above may be added into an aerosol can at 5% to 15% by total volume of the can. A propellant solvent selected from the group consisting of butane, isobutane, propane, pentane, and dimethyl ether may be added to the can to make up approximately 100% of the can volume. The propellant may be present at 20% to 70% by weight of the total composition in the aerosol can. The aerosol spray may be used by activating the pump to spray the content to the skin or any surfaces.
  • In another embodiment, the anti-microbial powder may be a powder for direct application to the infectious site. The cannabinoid powder from the shear mixer may be dried under vacuum at 60° C. until ethanol evaporates from the powder. The powder may be filled into sachets or containers and may be used for direct application to mammal skin and left for at least 3 minutes.
  • Apart from common anti-microbial uses, this cannabinoid anti-microbial composition may be used to treat toe nail fungus, MRSA infection, herpes virus infection, tinea pedis, burn wound infections, sun burns, diabetic infections, eczema, impetigo, dermatophytosis, psoriasis, itchy skin, atopic dermatitis, dandruff, and general topical infections on human skin. The cannabinoid anti-microbial composition may be applied to the infected site in therapeutically effective amounts and left on the skin for at least 3 minutes.
  • The cannabinoid anti-microbial composition may also be used to disinfect any surface. An effective amount of the cannabinoid anti-microbial composition may be applied to a surface and left on the surface for at least 3 minutes.
  • Specific formulation processes are provided in the below examples for several embodiments.
    • EXAMPLES Example 1
  • Anti-microbial Spray
    Ingredients Percentage
    Water 45.600
    Ethanol 40.000
    CBG (solid) 5.000
    PEG 40 hydrogenated castor oil 5.000
    Glycerin 3.000
    Disodium gluconate 0.200
    Methyl gluceth-10 0.200
    Ethylhexyl glycerin/phenoxyethanol 0.500
    Fragrance 0.500
    NaOH (pH adjustment) qs
    Total 100.00
  • Ingredients are obtained according to the above percentage. CBG in solid form is dissolved in ethanol in a beaker by stirring. Add PEG-40 into the beaker and stir until uniform. Add the beaker's content into water in another container and stir the mixture until uniform. Add glycerin, disodium gluconate, methyl gluceth-10 and stir until the solution is clear. Add ethylhexyl glycerin and stir until uniform. Lastly, add fragrance and stir until clear. The mixture's pH is adjusted to pH=6.
    • Example 2
  • Anti-microbial Cream
    Ingredients Percentage
    Water 44.000
    Ethanol 30.000
    CBG 5.000
    PEG 40 hydrogenated castor oil 7.000
    Glycerin 3.000
    Polyvinylpyrrolidone 10.000
    Ethylhexyl glycerin/phenoxyethanol 0.500
    Fragrance 0.500
    NaOH qs
    Total 100.00
  • Ingredients are obtained according to the above percentage. Dissolve polyvinylpyrrolidonce in water to form the water phase and set aside. Dissolve CBG in ethanol and stir until the solution is clear, add PEG 40 to form the ethanol phase and stir until the solution is clear. Add the water and ethanol phases together, then add glycerin and stir until the solution is clear. Add ethylhexyl glycerin/phenoxyethanol and stir until the solution is clear. Add fragrance as needed and stir until clear, then adjust pH to 6.
    • Example 3
  • Anti-microbial Liquid (Hand Cleaner)
    Ingredients Percentage
    Aqua 48.000
    Sodium lauryl sulphate 5.000
    Ethanol 40.000
    CBG 7.000
    Total 100.000
  • Ingredients are obtained according to the above percentage. CBG is dissolved in ethanol in a beaker and stirred. Add sodium laurylsulphate into the beaker and stir until the solution is clear. Add this solution in to water in another beaker and stir until clear. The resulting liquid is packaged for dispensing.
    • Example 4
  • Anti-microbial Powder
    Ingredients Percentage
    Hydrated silica 30
    Talc 44
    Butylhydroxytoluene 0.5
    Dimethyl polysiloxilane 5
    Isopropyl myristate 5
    Fragrance 0.5
    Ethanol 10
    CBG 5
    Total 100
  • Ingredients are obtained according to the above percentages. Dissolve CBG in ethanol in a beaker. Add butylhydroxytoluene, dimethyl polysiloxilane, isopropyl myristate, and fragrance into the beaker, then stir until homogenous. In a shear mixer, add talc and hydrated silica then mix until homogenous. Add the beaker's content from above into the shear mixer and mix to obtain a homogenous powder.
  • The powder mixture from the shear mixer may be added into an aerosol can at 10% volume of the can. Add propane to fill the aerosol can, and the aerosol cannabinoid powder may be applied to infection sites.
  • Alternatively, powder from the shear mixer is dried under vacuum at 60° C. to evaporate the ethanol. The cannabinoid antibacterial powder may be used to apply to infection sites.
  • All references, including publications, patent applications, and patents cited herein are hereby incorporated by reference to the same extent as if each reference were individually and specifically indicated to be incorporated by reference and were set forth in its entirety herein.
  • It will be readily apparent to those skilled in the art that a number of modifications and changes may be made without departing from the spirit and the scope of the present invention. It is to be understood that any ranges, ratios, and range of ratios that can be derived from any of the data disclosed herein represent further embodiments of the present disclosure and are included as part of the disclosure as though they were explicitly set forth. This includes ranges that can be formed that do or do not include a finite upper and/or lower boundary. Accordingly, a person of ordinary skill in the art will appreciate that such values are unambiguously derivative from the data presented herein.

Claims (21)

1. An anti-microbial composition in cream form comprising:
at least one cannabinoid at 2% to 5% by weight of the total composition;
at least one alcoholic solvent at 20% to 40% by weight of the total composition;
a humectant at 1% to 5% by weight of the total composition;
an emulsifier at 2% to 15% by weight of the total composition; and
water at 30% to 50% by weight of the total composition.
2. The anti-microbial composition of claim 1, further comprising a binding agent selected from the group consisting of alginic acid, ammonium alginate, calcium caseinate, calcium sulfate hydrate, polyvinyl acetate, polyacrylic acid, polyisobutylene, potassium alginate, propylene glycol alginate, and polyvinylpyrrolidone.
3. The anti-microbial composition of claim 2, wherein the binding agent is present at 5% to 20% by weight of the total composition.
4. The anti-microbial composition of claim 2, further comprising a skin conditioning agent selected from the group consisting of amodimethicone, alkyl benzoate, caprylyl glycol, cetyl palminate, cyclo-dimethicone, dimethicone 500, dimethicone satin, ethylhexyl glycerin, iso-dimethicone copolymer, isododecane, isoeicosane, isolanolin, lanolin alcohol, octyldodecanol, PEG-8 dimethicone, and polyamide 3.
5. The anti-microbial composition of claim 4, wherein the skin conditioning agent is present at 0.1% to 2% by weight of the total composition.
6. The anti-microbial composition of claim 5, further comprising a fragrance.
7. An anti-microbial spray comprising:
at least one cannabinoid at 2% to 5% by weight of the total composition selected from the group consisting of cannabidiol, cannabigerol, tetrahydrocannabinol, cannabidivarin, and tetrahydrocannabivarin;
a humectant at 1% to 5% by weight of the total composition selected from the group consisting of glycerin, hyaluronic acid, lacto-ceramide, hydrolyzed keratin protein, and hydrolyzed collagen protein;
an emulsifier at 2% to 15% by weight of the total composition selected from the group consisting of PEG 40 hydrogenated castor oil, disodium PEG-4-cocoamido MIPA sulfosuccinate, lauryl glucoside, methyl gluceth-10, and sodium lauroamphoacetate;
at least one alcohol at 30% to 45% by weight of the total composition selected from the group consisting of ethanol and isopropyl alcohol; and
water at 30% to 50% by weight of the total composition.
8. The anti-microbial spray of claim 7, further comprising a chelating agent present at 0.05% to 0.5% by weight of the total composition selected from the group consisting of disodium gluconate, disodium EDTA, tetrasodium EDTA, and tetrasodium glutamate diacetate.
9. The anti-microbial spray of claim 8, further comprising a skin conditioning agent present at 0.1% to 2% by weight of the total composition selected from the group consisting of amodimethicone, alkyl benzoate, caprylyl glycol, cetyl palminate, cyclo-dimethicone, dimethicone 500, dimethicone satin, ethylhexyl glycerin, iso-dimethicone copolymer, isododecane, isoeicosane, isolanolin, lanolin alcohol, octyldodecanol, PEG-8 dimethicone, and polyamide 3.
10. The anti-microbial spray of claim 9, further comprising a fragrance.
11. An anti-microbial liquid comprising:
at least one cannabinoid at 5% to 10% by weight of the total composition selected from the group consisting of cannabidiol, cannabigerol, tetrahydrocannabinol, cannabidivarin, and tetrahydrocannabivarin;
a surfactant at 3% to 10% by weight of the total composition selected from the group consisting of sodium lauryl sulfate, ammonium lauryl sulfate, sodium laureth sulfate, and sodium myreth sulfate;
at least one alcohol at 30% to 45% by weight of the total composition selected from the group consisting of ethanol or isopropyl alcohol; and
water at 35% to 55% by weight of the total composition.
12. An anti-microbial powder comprising:
at least one cannabinoid at 5% to 10% by weight of the total composition selected from the group consisting of cannabidiol, cannabigerol, tetrahydrocannabinol, cannabidivarin, and tetrahydrocannabivarin;
at least one preservative at 0.2% to 1.5% by weight of the total composition selected from the group consisting of butylhydroxytoluene, phenoxyethanol, paraben, and potassium sorbate;
at least one emollient at 3% to 20% by weight of the total composition selected from the group consisting of dimethyl polysiloxilane, isopropyl myristate, amodimethicone, cetyl palmitate, cyclomethicone, dimethicone 500, and isododecane; and
a powder comprising talc and hydrated silica at 20% to 90% by weight of the total composition.
13. The anti-microbial powder of claim 12, further comprising:
at least one alcohol at 20% to 80% by weight of the total composition selected from the group consisting of ethanol and isopropyl alcohol; and
at least one propellant solvent at 20% to 70% by weight of the total composition selected from the group consisting of butane, isobutane, propane, pentane, and dimethyl ether.
14. The anti-microbial powder of claim 13, wherein the powder is packaged in an aerosol can.
15. A method to make an anti-microbial composition comprising the steps of:
dissolving at least one solid cannabinoid into an alcohol to form a solution;
adding at least one of an emulsifier, a humectant, a chelating agent, a binding agent, or a skin conditioning agent to the solution;
stirring the solution;
adding water to the solution; and
stirring the solution.
16. The method of claim 15, further comprising the steps of:
adding a fragrance to the solution; and
adjusting the solution's pH to 6.
17. A method to make an anti-microbial powder comprising the steps of:
dissolving at least one solid cannabinoid into an alcohol to form a solution;
adding at least one emollient and at least one preservative into the solution from the first step;
adding the solution from the second step into a powder comprising talc and hydrated silica to form a powder;
mixing the powder mixture in a shear mixer;
adding the powder into an aerosol can; and
adding at least one propellant selected from the group consisting of butane, isobutane, propane, pentane, and dimethyl ether.
18. The method of claim 17, further comprising the step of removing the alcohol by vacuum.
19. A method to disinfect a surface comprising the steps of:
applying an effective amount of a composition according to claim 1 to a surface; and
leaving the composition on the surface for at least 3 minutes,
wherein the surface is either mammal skin or non-living surfaces.
20. A method to treat an infection on human skin comprising the steps of:
applying a therapeutically effective amount of a composition according to claim 1 to the skin; and
leaving the composition on the skin for at least 3 minutes,
wherein the infection is selected from the group consisting of toe nail fungus, MRSA infection, herpes virus infection, tinea pedis, burn wound infections, sun burns, diabetic infections, eczema, impetigo, dermatophytosis, psoriasis, itchy skin, atopic dermatitis, dandruff, and general topical infections.
21. The anti-microbial composition of claim 1, wherein:
the at least one cannabinoid is selected from the group consisting of cannabidiol, cannabigerol, tetrahydrocannabinol, cannabidivarin, and tetrahydrocannabivarin;
the at least one alcoholic solvent is selected from the group consisting of ethanol and isopropyl alcohol;
the humectant is selected from the group consisting of glycerin, hyaluronic acid, lacto-ceramide, hydrolyzed keratin protein, and hydrolyzed collagen protein, and
the emulsifier is selected from the group consisting of PEG 40 hydrogenated castor oil, disodium PEG-4-cocoamido MIPA sulfosuccinate, lauryl glucoside, and sodium lauroamphoacetate.
US15/188,143 2015-06-23 2016-06-21 Anti-microbial composition comprising cannabinoids Abandoned US20160374958A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US15/188,143 US20160374958A1 (en) 2015-06-23 2016-06-21 Anti-microbial composition comprising cannabinoids
US16/293,136 US10441552B2 (en) 2015-06-23 2019-03-05 Anti-microbial composition comprising cannabinoids
US16/545,808 US11058646B2 (en) 2015-06-23 2019-08-20 Anti-microbial compositions comprising cannabinoids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562183573P 2015-06-23 2015-06-23
US15/188,143 US20160374958A1 (en) 2015-06-23 2016-06-21 Anti-microbial composition comprising cannabinoids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US16/293,136 Continuation US10441552B2 (en) 2015-06-23 2019-03-05 Anti-microbial composition comprising cannabinoids

Publications (1)

Publication Number Publication Date
US20160374958A1 true US20160374958A1 (en) 2016-12-29

Family

ID=57585447

Family Applications (3)

Application Number Title Priority Date Filing Date
US15/188,143 Abandoned US20160374958A1 (en) 2015-06-23 2016-06-21 Anti-microbial composition comprising cannabinoids
US16/293,136 Active US10441552B2 (en) 2015-06-23 2019-03-05 Anti-microbial composition comprising cannabinoids
US16/545,808 Active US11058646B2 (en) 2015-06-23 2019-08-20 Anti-microbial compositions comprising cannabinoids

Family Applications After (2)

Application Number Title Priority Date Filing Date
US16/293,136 Active US10441552B2 (en) 2015-06-23 2019-03-05 Anti-microbial composition comprising cannabinoids
US16/545,808 Active US11058646B2 (en) 2015-06-23 2019-08-20 Anti-microbial compositions comprising cannabinoids

Country Status (5)

Country Link
US (3) US20160374958A1 (en)
EP (1) EP3313394A4 (en)
HK (1) HK1254812A1 (en)
MA (1) MA42268A (en)
WO (1) WO2016209802A1 (en)

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018085794A1 (en) * 2016-11-07 2018-05-11 Avidas Pharmaceuticals Llc Therapeutic cannabinoid formulations and methods for their use
US10053407B2 (en) * 2016-06-01 2018-08-21 S&B Pharma, Inc. Crystalline cannabidivarin
WO2018148787A1 (en) * 2017-02-15 2018-08-23 Botanix Pharmaceuticals Ltd Formulations of cannabinoids for the treatment of psoriasis
WO2018148785A1 (en) * 2017-02-15 2018-08-23 Botanix Pharmaceuticals Ltd Formulations of cannabinoids for the treatment of dermatitis and inflammatory skin diseases
WO2018148786A1 (en) * 2017-02-15 2018-08-23 Botanix Pharmaceuticals Ltd Formulations of cannabinoids for the treatment of acne
WO2018165078A1 (en) * 2017-03-06 2018-09-13 Korbutov Jack D Cannabinoid-containing dermatological compositions and methods using same
WO2018208875A1 (en) 2017-05-09 2018-11-15 Vitality Biopharma, Inc. Antimicrobial compositions comprising cannabinoids and methods of using the same
CN110283050A (en) * 2019-07-01 2019-09-27 大兴安岭林格贝寒带生物科技股份有限公司 Utilize the method for superhigh pressure technique enriching and purifying cannabidiol
CN110520123A (en) * 2017-02-15 2019-11-29 博塔尼克斯制药有限公司 For treating the cannabinoid formulation of psoriasis
CN110545807A (en) * 2017-02-15 2019-12-06 博塔尼克斯制药有限公司 Cannabinoid formulations for the treatment of dermatitis and inflammatory dermatoses
WO2020024056A1 (en) * 2018-08-01 2020-02-06 Lazar Eve Compositions comprising cannabinoids and absorbable material and uses thereof
CN110769819A (en) * 2017-02-15 2020-02-07 博塔尼克斯制药有限公司 Cannabinoid formulations for the treatment of acne
WO2020051284A1 (en) * 2018-09-05 2020-03-12 Nemus Bioscience, Inc. Cannabinoids for the treatment of gram-positive infections including antibiotic-resistant bacterial strains
CN111557900A (en) * 2020-05-22 2020-08-21 广州大洲生物医药科技有限公司 Cannabidiol cream, preparation method and application thereof
CN111936126A (en) * 2018-01-24 2020-11-13 博塔尼克斯制药有限公司 Cannabinoid dosing regimens for dermatitis and inflammatory skin disorders
CN112020352A (en) * 2018-01-24 2020-12-01 博塔尼克斯制药有限公司 Cannabinoid dosing regimens for acne
WO2020257588A1 (en) * 2019-06-20 2020-12-24 Shaman Naturals, Llc Compositions for preventing and treating viral infections
US20210177740A1 (en) * 2019-12-11 2021-06-17 Joel Studin Transpore delivery of cannabinoid and uses thereof
WO2021155390A1 (en) * 2020-01-14 2021-08-05 Shaman Naturals, Llc. Antimicrobial compositions
US11173128B2 (en) * 2018-04-27 2021-11-16 Thomas Jefferson University Nanospun hemp-based materials
US11207414B2 (en) 2015-09-22 2021-12-28 Graphium Biosciences, Inc. Cannabinoid glycoside prodrugs and methods of synthesis
WO2022077271A1 (en) * 2020-10-14 2022-04-21 Huang Yu Fen Polymeric flavonoids and use thereof
US20230085692A1 (en) * 2021-08-18 2023-03-23 P2 Science, Inc. Cannabis species as industrial chemical feedstocks
US11628129B2 (en) 2017-04-04 2023-04-18 Gojo Industries, Inc. Methods and compounds for increasing virucidal efficacy in hydroalcoholic systems

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10272051B2 (en) * 2017-08-28 2019-04-30 Axim Biotechnologies, Inc. Method to treat atopic dermatitis
US20190060250A1 (en) * 2017-08-28 2019-02-28 Axim Biotechnologies, Inc. Method to treat psoriasis
CN109498605B (en) * 2017-09-15 2020-12-01 汉义生物科技（北京）有限公司 Composition for treating gynecological inflammation and application thereof in external composition
AU2019210704A1 (en) * 2018-01-24 2020-08-06 Botanix Pharmaceuticals Ltd Cannabinoid dosing regime for psoriasis
CA3089750A1 (en) * 2018-01-29 2019-08-01 Solantech Inc. Methods of treating and/or preventing bedsores using nabilone
WO2019244160A1 (en) * 2018-06-20 2019-12-26 Tel Ari Ruben Cannabidiol-containing antimicrobial non-irritating hyperosmotic compositions
WO2020000024A1 (en) * 2018-06-28 2020-01-02 Botanix Pharmaceuticals Ltd Antibacterial treatment using cannabinoid combinations
WO2020180969A1 (en) * 2019-03-05 2020-09-10 Colleen Smith Veterinary compositions and methods of use therefor
US20220296535A1 (en) * 2019-06-18 2022-09-22 Botanix Pharmaceuticals Limited Antibacterial Dosage Regime Using Cannabinoids
US20230094265A1 (en) * 2020-01-30 2023-03-30 Innocan Pharma Ltd. Compositions for hemorrhoid treatment
WO2021188886A1 (en) * 2020-03-20 2021-09-23 Credo Science, Llc Antimicrobial compositions and methods
GB202010268D0 (en) * 2020-07-03 2020-08-19 Novabiotics Ltd Nail formulations and treatment regimes
US20220040623A1 (en) * 2020-08-07 2022-02-10 Bohde John Mold and fungal (mycotoxin) toxin remediation
US20220125755A1 (en) * 2020-10-24 2022-04-28 Kevin Hazen Cannabis time release apparatus and method of manufacture thereof
US20230310297A1 (en) 2022-04-01 2023-10-05 TF Holdings LLC Skin treatment composition containing cannabinoids
US20240041901A1 (en) 2022-08-02 2024-02-08 TF Holdings LLC Wound treatment topical composition containing cannabinoids

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120202891A1 (en) * 2009-04-29 2012-08-09 University Of Kentucky Research Foundation Cannabinoid-Containing Compositions and Methods for Their Use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223244A (en) * 1988-06-20 1993-06-29 Shiseido Company, Ltd. Aerosol composition
US5780020A (en) * 1996-10-28 1998-07-14 The Proctor & Gamble Company Methods and compositions for reducing body odor
US7025992B2 (en) * 2001-02-14 2006-04-11 Gw Pharma Limited Pharmaceutical formulations
US20040229939A1 (en) * 2003-02-14 2004-11-18 Chowdhury Dipak K. Tetrahydrocannabinol compositions and methods of manufacture and use thereof
JP2006522785A (en) * 2003-04-14 2006-10-05 ベクトゥラ・リミテッド Pharmaceutical composition for pulmonary inhalation comprising apomorphine
AU2013213706B2 (en) * 2005-11-07 2016-04-14 Murty Pharmaceuticals, Inc An improved oral dosage form of tetrahydrocannabinol and a method of avoiding and/or suppressing hepatic first pass metabolism via targeted chylomicron/lipoprotein delivery
WO2008111296A1 (en) * 2007-03-09 2008-09-18 Kyoto University Pharmaceutical agent for prevention and treatment of skin disease induced by accelerated keratinization
GB2450493A (en) * 2007-06-25 2008-12-31 Gw Pharma Ltd Cannabigerol for use in treatment of diseases benefiting from agonism of CB1 and CB2 cannabinoid receptors
US8222292B2 (en) * 2007-08-06 2012-07-17 Insys Therapeutics, Inc. Liquid cannabinoid formulations
ES2635084T3 (en) * 2009-08-31 2017-10-02 Zynerba Pharmaceuticals, Inc. Use of cannabidiol prodrugs in topical and transdermal administration with microneedles
WO2013009928A1 (en) * 2011-07-11 2013-01-17 Organic Medical Research Cannabinoid formulations

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120202891A1 (en) * 2009-04-29 2012-08-09 University Of Kentucky Research Foundation Cannabinoid-Containing Compositions and Methods for Their Use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Christina Burnett (Cosmetic Ingredient Review, published 2012, http://www.cir-safety.org/sites/default/files/pegoil122012final_faa-final%20for%20posting.pdf) *
Downie (Practical Dermatology, April 2011) *
Rowe et al. (Handbook of pharmaceutical excipients. London: Pharmaceutical Press, 2006. Print). *

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11207414B2 (en) 2015-09-22 2021-12-28 Graphium Biosciences, Inc. Cannabinoid glycoside prodrugs and methods of synthesis
US10053407B2 (en) * 2016-06-01 2018-08-21 S&B Pharma, Inc. Crystalline cannabidivarin
WO2018085794A1 (en) * 2016-11-07 2018-05-11 Avidas Pharmaceuticals Llc Therapeutic cannabinoid formulations and methods for their use
EP3582769A4 (en) * 2017-02-15 2020-11-18 Botanix Pharmaceuticals Ltd Formulations of cannabinoids for the treatment of psoriasis
JP2020508992A (en) * 2017-02-15 2020-03-26 ボタニクス ファーマシューティカルズ リミテッド Formulations of cannabinoids for the treatment of acne
AU2018221880B2 (en) * 2017-02-15 2023-08-17 Botanix Pharmaceuticals Ltd Formulations of cannabinoids for the treatment of dermatitis and inflammatory skin diseases
AU2018221881B2 (en) * 2017-02-15 2023-09-14 Botanix Pharmaceuticals Ltd Formulations of cannabinoids for the treatment of acne
IL268728B1 (en) * 2017-02-15 2024-05-01 Botanix Pharmaceuticals Ltd Formulations of cannabinoids for the treatment of acne
EP3582770A4 (en) * 2017-02-15 2020-11-18 Botanix Pharmaceuticals Ltd Formulations of cannabinoids for the treatment of acne
CN110545807A (en) * 2017-02-15 2019-12-06 博塔尼克斯制药有限公司 Cannabinoid formulations for the treatment of dermatitis and inflammatory dermatoses
JP7012089B2 (en) 2017-02-15 2022-01-27 ボタニクス ファーマシューティカルズ リミテッド Preparation of cannabinoids for the treatment of dermatitis and inflammatory bowel disease
CN110769819A (en) * 2017-02-15 2020-02-07 博塔尼克斯制药有限公司 Cannabinoid formulations for the treatment of acne
WO2018148786A1 (en) * 2017-02-15 2018-08-23 Botanix Pharmaceuticals Ltd Formulations of cannabinoids for the treatment of acne
JP2020508994A (en) * 2017-02-15 2020-03-26 ボタニクス ファーマシューティカルズ リミテッド Formulation of cannabinoids for the treatment of dermatitis and inflammatory skin diseases
WO2018148787A1 (en) * 2017-02-15 2018-08-23 Botanix Pharmaceuticals Ltd Formulations of cannabinoids for the treatment of psoriasis
CN110520123A (en) * 2017-02-15 2019-11-29 博塔尼克斯制药有限公司 For treating the cannabinoid formulation of psoriasis
US20220323401A1 (en) * 2017-02-15 2022-10-13 Botanix Pharmaceuticals Ltd. Formulations of cannabinoids for the treatment of acne
EP3582768A4 (en) * 2017-02-15 2020-11-18 Botanix Pharmaceuticals Ltd Formulations of cannabinoids for the treatment of dermatitis and inflammatory skin diseases
WO2018148785A1 (en) * 2017-02-15 2018-08-23 Botanix Pharmaceuticals Ltd Formulations of cannabinoids for the treatment of dermatitis and inflammatory skin diseases
IL268720B1 (en) * 2017-02-15 2024-05-01 Botanix Pharmaceuticals Ltd Formulations of cannabinoids for the treatment of dermatitis and inflammatory skin diseases
WO2018165078A1 (en) * 2017-03-06 2018-09-13 Korbutov Jack D Cannabinoid-containing dermatological compositions and methods using same
US11628129B2 (en) 2017-04-04 2023-04-18 Gojo Industries, Inc. Methods and compounds for increasing virucidal efficacy in hydroalcoholic systems
WO2018208875A1 (en) 2017-05-09 2018-11-15 Vitality Biopharma, Inc. Antimicrobial compositions comprising cannabinoids and methods of using the same
US11207291B2 (en) * 2017-05-09 2021-12-28 Graphium Biosciences, Inc. Antimicrobial compositions comprising cannabinoids and methods of using the same
CN111936126A (en) * 2018-01-24 2020-11-13 博塔尼克斯制药有限公司 Cannabinoid dosing regimens for dermatitis and inflammatory skin disorders
US11896560B2 (en) 2018-01-24 2024-02-13 Botanix Pharmaceuticals Ltd. Cannabinoid dosing regime for dermatitis and inflammatory skin conditions
CN112020352A (en) * 2018-01-24 2020-12-01 博塔尼克斯制药有限公司 Cannabinoid dosing regimens for acne
US11173128B2 (en) * 2018-04-27 2021-11-16 Thomas Jefferson University Nanospun hemp-based materials
WO2020024056A1 (en) * 2018-08-01 2020-02-06 Lazar Eve Compositions comprising cannabinoids and absorbable material and uses thereof
WO2020051284A1 (en) * 2018-09-05 2020-03-12 Nemus Bioscience, Inc. Cannabinoids for the treatment of gram-positive infections including antibiotic-resistant bacterial strains
EP3846616A4 (en) * 2018-09-05 2022-05-25 Nemus Bioscience, Inc. Cannabinoids for the treatment of gram-positive infections including antibiotic-resistant bacterial strains
WO2020257588A1 (en) * 2019-06-20 2020-12-24 Shaman Naturals, Llc Compositions for preventing and treating viral infections
CN110283050A (en) * 2019-07-01 2019-09-27 大兴安岭林格贝寒带生物科技股份有限公司 Utilize the method for superhigh pressure technique enriching and purifying cannabidiol
US20210177740A1 (en) * 2019-12-11 2021-06-17 Joel Studin Transpore delivery of cannabinoid and uses thereof
WO2021155390A1 (en) * 2020-01-14 2021-08-05 Shaman Naturals, Llc. Antimicrobial compositions
CN111557900A (en) * 2020-05-22 2020-08-21 广州大洲生物医药科技有限公司 Cannabidiol cream, preparation method and application thereof
WO2022077271A1 (en) * 2020-10-14 2022-04-21 Huang Yu Fen Polymeric flavonoids and use thereof
US20230085692A1 (en) * 2021-08-18 2023-03-23 P2 Science, Inc. Cannabis species as industrial chemical feedstocks

Also Published As

Publication number Publication date
HK1254812A1 (en) 2019-07-26
EP3313394A4 (en) 2019-02-27
US20200016095A1 (en) 2020-01-16
WO2016209802A1 (en) 2016-12-29
US20190209487A1 (en) 2019-07-11
EP3313394A1 (en) 2018-05-02
US10441552B2 (en) 2019-10-15
US11058646B2 (en) 2021-07-13
MA42268A (en) 2018-05-02

Similar Documents

Publication Publication Date Title
US11058646B2 (en) Anti-microbial compositions comprising cannabinoids
Panwar et al. Emulgel: A review
US9549905B2 (en) Treatment of inflammatory and infectious skin disorders
EP2348832B1 (en) Preservative system for emulsion-based therapeutic topical formulations
KR20170036058A (en) Cineole-containing composition for nasal application
US20210128518A1 (en) Cannabinoid-containing dermatological compositions and methods using same
WO2021217324A1 (en) Disinfectant composition, preparation method therefor, and use thereof
US20180339051A1 (en) Composition for topical application comprising dimethyl isosorbide, a polyol, and a phenolic or polyphenolic antioxidant
WO2013100089A1 (en) Anti-bacterial agent for oral applications which has excellent storage stability, and composition for oral care applications
KR102147642B1 (en) Cosmetic composition for acne improvement
JP2007332078A (en) Agent for external use containing ozone-dissolved glycerol solution such as cosmetic, quasi-drug or medicament (pharmaceutical)
US20040234628A1 (en) Topical composition for the treatment of skin disorders and methods of using the same
JP2009001575A (en) Agent for external use containing ozone-dissolved glycerol solution such as cosmetic, quasi-drug or medicament (pharmaceutical)
US20140073616A1 (en) Hydrocortisone nanotechnological delivery system
KR102658501B1 (en) Topical compositions and methods for treating and preventing atopic dermatitis and infections associated with bacterial biofilms
EP3638219B1 (en) Composition comprising terpinene-4-ol for the treatment of demodicosis
US11633425B2 (en) Anti-glycation compositions
US20240148762A1 (en) Topical composition containing cannabinoids
WO2021219939A1 (en) Salve composition, method of manufacture and use of the composition
TWI474841B (en) Preservative system for emulsion-based therapeutic topical formulations
US20230302028A1 (en) Pain-relieving topical compositions
WO2024028179A1 (en) Biocidal composition

Legal Events

Date Code Title Description
AS Assignment

Owner name: AXIM BIOTECHNOLOGIES, INC., NEW YORK

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ANASTASSOV, GEORGE;CHANGOER, LEKHRAM;VAN DAMME, PHILLIPUS;SIGNING DATES FROM 20160624 TO 20160630;REEL/FRAME:039059/0979

STPP Information on status: patent application and granting procedure in general

Free format text: FINAL REJECTION MAILED

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION