US20140294795A1 - Nutritional Composition - Google Patents

Nutritional Composition Download PDF

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Publication number
US20140294795A1
US20140294795A1 US13/852,472 US201313852472A US2014294795A1 US 20140294795 A1 US20140294795 A1 US 20140294795A1 US 201313852472 A US201313852472 A US 201313852472A US 2014294795 A1 US2014294795 A1 US 2014294795A1
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United States
Prior art keywords
mcg
vitamin
composition
present
selenium
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US13/852,472
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Houn Simon Hsia
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Individual
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Individual
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Priority to US13/852,472 priority Critical patent/US20140294795A1/en
Publication of US20140294795A1 publication Critical patent/US20140294795A1/en
Priority to US15/205,786 priority patent/US10117902B2/en
Priority to US16/156,990 priority patent/US10653733B2/en
Priority to US16/875,805 priority patent/US10946052B2/en
Priority to US17/200,056 priority patent/US11253561B2/en
Priority to US17/675,181 priority patent/US11576940B2/en
Priority to US18/079,155 priority patent/US20230113424A1/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/064Saccharomycetales, e.g. baker's yeast
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K33/24Heavy metals; Compounds thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/14Yeasts or derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/15Vitamins
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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    • A23L33/15Vitamins
    • A23L33/155Vitamins A or D
    • AHUMAN NECESSITIES
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    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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    • A23L33/16Inorganic salts, minerals or trace elements
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/175Amino acids
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    • A61K31/05Phenols
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
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    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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    • A61K31/28Compounds containing heavy metals
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    • A61K31/32Tin compounds
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    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4415Pyridoxine, i.e. Vitamin B6
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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    • A61K35/56Materials from animals other than mammals
    • A61K35/60Fish, e.g. seahorses; Fish eggs
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to nutritional compositions useful for increasing the efficacy of cancer therapies, including chemotherapy, radiation and target therapies; and more specifically to nutritional compositions to promote anti-tumor activity.
  • Cancer is one of the most deadly diseases of all centuries. Preventing and treatment of cancer is, therefore, and extremely important endeavor for centuries to pursue. Much progress has been made over the last 50 years for the treatment of cancer, including chemotherapeutic, radiation and most recently, target therapies. A major shortcoming of these therapeutic treatments is their harmful effects to the human system since, in many cases, the practice of such therapies causes severe weight loss, hair loss, and in many cases, death.
  • the present invention overcomes the shortcomings of the art of cancer therapy by providing compositions that work together to enhance the immune system such that the health of the cancer patient is not compromised by the harsh effects of the cancer therapies, and as a result, can overcome such effects, resulting in more efficient cancer remedial therapeutic treatments.
  • the present invention provides nutritional compositions that are employed as oral supplementation to the human diet.
  • the compositions of the present invention provide for supplementation to the diet of the cancer patient, as well as preventative dietary supplementation aimed at supporting the human immune system for those not currently suffering from cancer.
  • the present invention teaches a combination of specific nutritients suitable for oral consumption by the human body.
  • the compositions of the present invention when orally ingested on a daily basis, in combination with or without therapeutic treatments for cancer, specifically chemotherapy, target therapy and radiation therapy, work in a synergistic fashion together to aid the cancer patient in eliminating the cancer, healing of the cancer and recovery from the cancer.
  • the compositions of the present invention may also be ingested on a daily, or periodic basis to help prevent cancer.
  • compositions of the present invention Although the mechanism of action of the compositions of the present invention are not well understood, many cases have been reported of cancer patients benefiting from the use of the present invention in combination with the therapeutic treatments for cancer. It is believed that the key ingredients of the present invention work synergistically together to aid in the anti-neoplastic processes.
  • the recent publication entitled “Reduction of Splenic Immunosuppressive Cells and Enhancement of Anti-Tumor Immunity by Synergy of Fish Oil and Selenium Yeast” Wang h, Chan Y-L, et al. (2013) PLoS ONE 8(1):e52912. Dol:10.1371/journal.pone.005912) provides evidence that indeed the compositions of the present invention provide said synergistic action, and also that the compositions taught by the present invention are novel and useful for the prevention and treatment of cancer.
  • compositions include as preferred embodiment selenium.
  • the preferred form of selenium is selenium yeast.
  • the preferred amount of selenium yeast is from about 5 mcg to about 500 mcg, and more preferred between about 10 mcg to about 250 mcg, and most preferably from between 25 mcg to about 150 mcg.
  • the preferred selenium yeast are Saccharomyces cerevisiae, Saccharomyces exiguous, Saccharomyces pastorianus, Saccharomyces boulardii, Saccharomyces bayanus, Saccharomyces eubayanus, Saccharomyces florentinus, Saccharomyces fragilis.
  • the preferred fish oil has an EDA/DHA ratio of from between 1 part EPA to about 5 parts DHA, and from between 5 parts EPA to 1 part DHA, and more preferably from about 2 parts EPA to 1 part DHA, and most preferably from about 3 parts EPA to about 2 parts DHA.
  • the EPA/DHA content of the fish oil preparations of the present invention are from between 10% to about 90%, more preferably from between 30% to about 70% and most preferably from about 40% to about 60%.
  • the preferred amounts of fish oil EPA/DHA preparation of the present invention is from 0.50 mg to about 1.5 g, and more preferably between 250 mg to about 1000 mg, and most preferably between 350 mg to about 750 mg.
  • Beta Carotene Another essential component of the present invention is Beta Carotene.
  • the preferred form of beta carotene is the naturally occurring form.
  • the preferred amount is between 500 iu and 10,000 iu, and more preferably between 1500 iu and 7500 iu, and most preferably between about 1000 iu and 3000 iu.
  • Resverotrol is another important nutrient of the present invention.
  • the preferred form of Resverotrol is from plan extract.
  • the preferred amount of Resverotrol in the extract is from between 50% to about 98%, and most preferably about 95%.
  • the preferred amount of Resverotrol extract to be employed in the present invention is from about 5 mg to about 1500 mg, and more preferably from about 50 mg to about 300 mg, and most preferably from about 75 mg to about 150 mg.
  • Vitamin D3 may be added to the nutritional compositions of the present invention.
  • the preferred form of Vitamin D3 is Cholecalciferol.
  • the preferred amount of Vitamin D3 is from between 50 iu and 3000 iu, and more preferably between from about 70 iu to about 500 iu, and most preferably from about 100 iu to about 250 iu.
  • Vitamin K Another prime nutrient that may be included in the embodiments of the present invention is Vitamin K.
  • the preferred form of Vitamin K is Phytonadione.
  • the preferred amount of Vitamin K is between 2.5 mcg to about 250 mcg, more preferably from between 15 mcg to about 100 mcg, and most preferably between 20 mcg to about 75 mcg.
  • Vitamin B6 Another nutrient important to the efficacy of the present invention is Vitamin B6.
  • the preferred form of Vitamin B6 is Pyridoxine hydrochloride.
  • the preferred amount is between 0.1 mg to about 100 mg, most preferably between about 0.5 mg to about 25 mg, and most preferably from about 0.75 mg to about 10 mg.
  • Vitamin B 12 may be included in the present invention.
  • the preferred form of Vitamin B12 is Cyanocobalamin.
  • the preferred amount of Vitamin B12 is between about 0.3 mcg to about 900 mcg, most preferably between about 0.75 mcg to about 50 mcg, and most preferably between 1 mcg and 10 mcg.
  • Folic Acid Another nutrient that is important to the present invention is Folic Acid.
  • the preferred amount of Folic Acid is between about 25 mcg to about 1000 mcg, most preferably between about 100 mcg to about 750 mcg, and most preferably between 200 mcg and 400 mcg.
  • the mineral Zinc is important to include in the present invention.
  • the preferred amount of Zinc is between about 0.65 mcg to about 4000 mcg, most preferably between about 1 mcg to about 400 mcg, and most preferably between 3 mcg and 50 mcg.
  • the mineral Chromium is important to include in the present invention.
  • the preferred form of Chromium is from yeast.
  • the preferred amount of Chromium is between about 30 mcg to about 3000 mcg, most preferably between about 50 mcg to about 500 mcg, and most preferably between 25 mcg and 100 mcg.
  • the mineral Molybdenum is important to include in the present invention.
  • the preferred form of Molybdenum is from yeast.
  • the preferred amount of Molybdenum is between about 2.5 mcg to about 1000 mcg, most preferably between about 10 mcg to about 130 mcg, and most preferably between 15 mcg and 60 mcg.
  • the amino acid glutamine is important to include in the present invention.
  • the preferred amount of glutamine is between about 2.1 g to about 250 g, most preferably between about 11 g to about 135 g, and most preferably between 10 g and 50 g.
  • the amino acid arginine is important to include in the present invention.
  • the preferred amount of argenine is between about 0.71 g to about 25 g, most preferably between about 3.0 g to about 15 g, and most preferably between 5 g and 13 g.
  • the amino acid taurine is important to include in the present invention.
  • the preferred amount of taurine is between about 1.1 g to about 29 g, most preferably between about 2.3 g to about 15 g, and most preferably between 3 g and 11 g.
  • the amino acid lysine is important to include in the present invention.
  • the preferred amount of taurine is between about 0.81 g to about 49 g, most preferably between about 5.3 g to about 35 g, and most preferably between 6 g and 18 g.
  • Coenzyme Q-10 Another important nutrient is Coenzyme Q-10.
  • the preferred amount of Coenzyme Q-10 is from about 30 mg to about 1000 mg, most preferably from between about 50 mg to 300 mg, and most preferably between about 60 mg to about 180 mg.
  • the above ingredients were admixed and shaken until homogeneous blend was obtained.
  • the blended composition was poured into 250 mL of water, mixed and then consumed via drinking.
  • the above ingredients were admixed and shaken until homogeneous blend was obtained.
  • the blended composition was poured into 250 mL of water, mixed and then consumed via drinking.
  • the above ingredients were admixed and shaken until homogeneous blend was obtained.
  • the blended composition was poured into 250 mL of water, mixed and then consumed via drinking.
  • the above ingredients were admixed and shaken until homogeneous blend was obtained.
  • the blended composition was poured into 250 mL of water, mixed and then consumed via drinking.
  • the above ingredients were admixed and shaken until homogeneous blend was obtained.
  • the blended composition was poured into 250 mL of water, mixed and then consumed via drinking.
  • the above ingredients were admixed and shaken until homogeneous blend was obtained.
  • the blended composition was poured into 250 mL of water, mixed and then consumed via drinking.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

The present invention provides nutritional compositions that are employed as oral supplementation to the human diet. The compositions of the present invention provide for supplementation to the diet of the cancer patient, as well as preventative dietary supplementation aimed at supporting the human immune system for those not currently suffering from cancer. The present invention is comprised of specific combinations of selected forms of unique sets of certain vitamins, minerals, protein, carbohydrates and phytochemicals.

Description

    FIELD OF THE INVENTION
  • The present invention relates to nutritional compositions useful for increasing the efficacy of cancer therapies, including chemotherapy, radiation and target therapies; and more specifically to nutritional compositions to promote anti-tumor activity.
  • BACKGROUND OF THE INVENTION
  • Cancer is one of the most deadly diseases of all mankind. Preventing and treatment of cancer is, therefore, and extremely important endeavor for mankind to pursue. Much progress has been made over the last 50 years for the treatment of cancer, including chemotherapeutic, radiation and most recently, target therapies. A major shortcoming of these therapeutic treatments is their harmful effects to the human system since, in many cases, the practice of such therapies causes severe weight loss, hair loss, and in many cases, death.
  • It is believed that one of the major causes of the ill-effects of cancer therapies is that they tax the human immune system. A healthy and potent human immune system is very important to combat the ill-effects of the cancer therapies. The present invention overcomes the shortcomings of the art of cancer therapy by providing compositions that work together to enhance the immune system such that the health of the cancer patient is not compromised by the harsh effects of the cancer therapies, and as a result, can overcome such effects, resulting in more efficient cancer remedial therapeutic treatments.
  • SUMMARY OF THE INVENTION
  • The present invention provides nutritional compositions that are employed as oral supplementation to the human diet. The compositions of the present invention provide for supplementation to the diet of the cancer patient, as well as preventative dietary supplementation aimed at supporting the human immune system for those not currently suffering from cancer.
  • It is a prime objective of the present invention to provide nutritive compositions that when used in combination with radiation, target or chemotherapy, provide for an increased activity in combating neoplastic growth.
  • It is another objective of the present invention to provide for anti-neoplastic effects by dietary supplementation utilizing specific forms of nutrients such as selenium yeast and fish oil.
  • It is another objective of the present invention to provide for compositions that help prevent cancer.
  • DETAILED DESCRIPTION OF THE INVENTION
  • The present invention teaches a combination of specific nutritients suitable for oral consumption by the human body. The compositions of the present invention when orally ingested on a daily basis, in combination with or without therapeutic treatments for cancer, specifically chemotherapy, target therapy and radiation therapy, work in a synergistic fashion together to aid the cancer patient in eliminating the cancer, healing of the cancer and recovery from the cancer. The compositions of the present invention may also be ingested on a daily, or periodic basis to help prevent cancer.
  • Although the mechanism of action of the compositions of the present invention are not well understood, many cases have been reported of cancer patients benefiting from the use of the present invention in combination with the therapeutic treatments for cancer. It is believed that the key ingredients of the present invention work synergistically together to aid in the anti-neoplastic processes. The recent publication entitled “Reduction of Splenic Immunosuppressive Cells and Enhancement of Anti-Tumor Immunity by Synergy of Fish Oil and Selenium Yeast” (Wang h, Chan Y-L, et al. (2013) PLoS ONE 8(1):e52912. Dol:10.1371/journal.pone.005912) provides evidence that indeed the compositions of the present invention provide said synergistic action, and also that the compositions taught by the present invention are novel and useful for the prevention and treatment of cancer.
  • These compositions include as preferred embodiment selenium. The preferred form of selenium is selenium yeast. The preferred amount of selenium yeast is from about 5 mcg to about 500 mcg, and more preferred between about 10 mcg to about 250 mcg, and most preferably from between 25 mcg to about 150 mcg. The preferred selenium yeast are Saccharomyces cerevisiae, Saccharomyces exiguous, Saccharomyces pastorianus, Saccharomyces boulardii, Saccharomyces bayanus, Saccharomyces eubayanus, Saccharomyces florentinus, Saccharomyces fragilis.
  • Another essential ingredient of the present invention is fish oil. The preferred fish oil has an EDA/DHA ratio of from between 1 part EPA to about 5 parts DHA, and from between 5 parts EPA to 1 part DHA, and more preferably from about 2 parts EPA to 1 part DHA, and most preferably from about 3 parts EPA to about 2 parts DHA. The EPA/DHA content of the fish oil preparations of the present invention are from between 10% to about 90%, more preferably from between 30% to about 70% and most preferably from about 40% to about 60%. The preferred amounts of fish oil EPA/DHA preparation of the present invention is from 0.50 mg to about 1.5 g, and more preferably between 250 mg to about 1000 mg, and most preferably between 350 mg to about 750 mg.
  • Another essential component of the present invention is Beta Carotene. The preferred form of beta carotene is the naturally occurring form. The preferred amount is between 500 iu and 10,000 iu, and more preferably between 1500 iu and 7500 iu, and most preferably between about 1000 iu and 3000 iu.
  • Resverotrol is another important nutrient of the present invention. The preferred form of Resverotrol is from plan extract. The preferred amount of Resverotrol in the extract is from between 50% to about 98%, and most preferably about 95%. The preferred amount of Resverotrol extract to be employed in the present invention is from about 5 mg to about 1500 mg, and more preferably from about 50 mg to about 300 mg, and most preferably from about 75 mg to about 150 mg.
  • Additionally, Vitamin D3 may be added to the nutritional compositions of the present invention. The preferred form of Vitamin D3 is Cholecalciferol. The preferred amount of Vitamin D3 is from between 50 iu and 3000 iu, and more preferably between from about 70 iu to about 500 iu, and most preferably from about 100 iu to about 250 iu.
  • Another prime nutrient that may be included in the embodiments of the present invention is Vitamin K. The preferred form of Vitamin K is Phytonadione. The preferred amount of Vitamin K is between 2.5 mcg to about 250 mcg, more preferably from between 15 mcg to about 100 mcg, and most preferably between 20 mcg to about 75 mcg.
  • Another nutrient important to the efficacy of the present invention is Vitamin B6. The preferred form of Vitamin B6 is Pyridoxine hydrochloride. The preferred amount is between 0.1 mg to about 100 mg, most preferably between about 0.5 mg to about 25 mg, and most preferably from about 0.75 mg to about 10 mg.
  • Additionally, Vitamin B 12 may be included in the present invention. The preferred form of Vitamin B12 is Cyanocobalamin. The preferred amount of Vitamin B12 is between about 0.3 mcg to about 900 mcg, most preferably between about 0.75 mcg to about 50 mcg, and most preferably between 1 mcg and 10 mcg.
  • Another nutrient that is important to the present invention is Folic Acid. The preferred amount of Folic Acid is between about 25 mcg to about 1000 mcg, most preferably between about 100 mcg to about 750 mcg, and most preferably between 200 mcg and 400 mcg.
  • The mineral Zinc is important to include in the present invention. The preferred amount of Zinc is between about 0.65 mcg to about 4000 mcg, most preferably between about 1 mcg to about 400 mcg, and most preferably between 3 mcg and 50 mcg.
  • The mineral Chromium is important to include in the present invention. The preferred form of Chromium is from yeast. The preferred amount of Chromium is between about 30 mcg to about 3000 mcg, most preferably between about 50 mcg to about 500 mcg, and most preferably between 25 mcg and 100 mcg.
  • The mineral Molybdenum is important to include in the present invention. The preferred form of Molybdenum is from yeast. The preferred amount of Molybdenum is between about 2.5 mcg to about 1000 mcg, most preferably between about 10 mcg to about 130 mcg, and most preferably between 15 mcg and 60 mcg.
  • The amino acid glutamine is important to include in the present invention. The preferred amount of glutamine is between about 2.1 g to about 250 g, most preferably between about 11 g to about 135 g, and most preferably between 10 g and 50 g.
  • The amino acid arginine is important to include in the present invention. The preferred amount of argenine is between about 0.71 g to about 25 g, most preferably between about 3.0 g to about 15 g, and most preferably between 5 g and 13 g.
  • The amino acid taurine is important to include in the present invention. The preferred amount of taurine is between about 1.1 g to about 29 g, most preferably between about 2.3 g to about 15 g, and most preferably between 3 g and 11 g.
  • The amino acid lysine is important to include in the present invention. The preferred amount of taurine is between about 0.81 g to about 49 g, most preferably between about 5.3 g to about 35 g, and most preferably between 6 g and 18 g.
  • Another important nutrient is Coenzyme Q-10. The preferred amount of Coenzyme Q-10 is from about 30 mg to about 1000 mg, most preferably from between about 50 mg to 300 mg, and most preferably between about 60 mg to about 180 mg.
  • The following examples are illustrative only and do not limit the invention in any fashion.
  • Example 1
  • Ingredient Amount
    Fish Oil 70 mg
    Selenium (from Selenium yeast) 2500 mcg
    Beta Carotene 1000 iu
    Vitamin D3 100 iu
    Vitamin K 15 mcg
    Vitamin B6 0.5 mg
    Vitamin B12 1 mcg
    Folic Acid 250 mcg
    Zinc 5.0 mg
    Chromium 25 mcg
    Molybdenum 15 mcg
    Glutamine 20 g
    Argenine 5.1 g
    Taurine 3.2 g
    Lysine 7.3 g
    CoQ-10 50 mg
    Niacin 2.1 mg
    Riboflavin 600 mcg
    Thiamin 530 mcg
    Biotin 2 mg
    Calcium 200 mg
    Iron 3 mg
    Phosphourous 213 mg
    Iodine 35 mg
    Copper 500 mcg
    Manganese 570 mcg
    Inositol 1.2 g
    Sucrose 3.5 g
    Whey Protein Isolate 0.75 g
    Non-Fat Milk 0.2 g
    Rice Protien 0.23 g
    Calcium Caseinate 0.14 g
    Soy Lecithin 0.1 g
  • The above ingredients were admixed and shaken until homogeneous blend was obtained. The blended composition was poured into 250 mL of water, mixed and then consumed via drinking.
  • Example 2
  • Ingredient Amount
    Fish Oil 70 mg
    Selenium (from Selenium yeast) 2500 mcg
    Beta Carotene 1000 iu
    Vitamin D3 100 iu
    Vitamin K 15 mcg
    Vitamin B6 0.5 mg
    Vitamin B12 1 mcg
    Folic Acid 250 mcg
    Iron 3 mg
    Phosphourous 213 mg
    Iodine 35 mg
    Copper 500 mcg
    Manganese 570 mcg
    Inositol 1.2 g
    Sucrose 3.5 g
    Whey Protein Isolate 0.75 g
    Non-Fat Milk 0.2 g
    Rice Protien 0.23 g
    Calcium Caseinate 0.14 g
    Soy Lecithin 0.1 g
  • The above ingredients were admixed and shaken until homogeneous blend was obtained. The blended composition was poured into 250 mL of water, mixed and then consumed via drinking.
  • Example 3
  • Ingredient Amount
    Fish Oil 90 mg
    Selenium (from Selenium yeast) 2540 mcg
    Beta Carotene 1300 iu
    Vitamin D3 80 iu
    Vitamin K 15 mcg
    Vitamin B6 0.5 mg
    Vitamin B12 1 mcg
    Folic Acid 250 mcg
    Zinc 3.0 mg
    Chromium 25 mcg
    Molybdenum 25 mcg
    Glutamine 29 g
    Argenine 7.1 g
    Taurine 3.2 g
    Lysine 7.6 g
    CoQ-10 100 mg
    Manganese 570 mcg
    Inositol 2.7 g
    Sucrose 3.5 g
    Whey Protein Isolate 0.75 g
    Non-Fat Milk 0.2 g
    Rice Protien 0.23 g
    Calcium Caseinate 0.14 g
    Soy Lecithin 0.1 g
  • The above ingredients were admixed and shaken until homogeneous blend was obtained. The blended composition was poured into 250 mL of water, mixed and then consumed via drinking.
  • Example 4
  • Ingredient Amount
    Fish Oil 110 mg
    Selenium (from Selenium yeast) 1500 mcg
    Beta Carotene 200 iu
    Vitamin D3 100 iu
    Vitamin K 15 mcg
    Vitamin B6 0.5 mg
    Vitamin B12 1 mcg
    Folic Acid 250 mcg
    Zinc 5.0 mg
    Chromium 25 mcg
    Molybdenum 15 mcg
    Glutamine 20 g
    Argenine 5.1 g
    Taurine 3.2 g
    Lysine 7.3 g
    CoQ-10 50 mg
    Niacin 2.1 mg
    Riboflavin 600 mcg
    Thiamin 530 mcg
    Biotin 2 mg
    Calcium 200 mg
    Iron 3 mg
    Phosphourous 213 mg
    Iodine 35 mg
    Copper 500 mcg
    Manganese 570 mcg
    Inositol 1.2 g
    Sucrose 3.5 g
    Whey Protein Isolate 0.75 g
    Non-Fat Milk 0.2 g
    Rice Protien 0.23 g
    Calcium Caseinate 0.14 g
    Soy Lecithin 0.1 g
  • The above ingredients were admixed and shaken until homogeneous blend was obtained. The blended composition was poured into 250 mL of water, mixed and then consumed via drinking.
  • Example 5
  • Ingredient Amount
    Fish Oil 90 mg
    Selenium (from Selenium yeast) 1560 mcg
    Beta Carotene 900 iu
    Vitamin D3 92 iu
    Vitamin K 23 mcg
    Vitamin B6 5.5 mg
    Vitamin B12 3 mcg
    Folic Acid 250 mcg
    Zinc 6.0 mg
    Chromium 25 mcg
    Molybdenum 15 mcg
    Glutamine 23 g
    Argenine 5.1 g
    Taurine 2.2 g
    Lysine 7.3 g
    CoQ-10 50 mg
    Niacin 2.1 mg
    Riboflavin 600 mcg
    Thiamin 530 mcg
    Biotin 2 mg
    Calcium 200 mg
    Iron 3 mg
    Phosphourous 213 mg
    Iodine 35 mg
    Copper 500 mcg
    Manganese 570 mcg
    Inositol 1.2 g
    Sucrose 3.5 g
    Whey Protein Isolate 0.75 g
    Non-Fat Milk 0.2 g
    Rice Protien 0.23 g
    Calcium Caseinate 0.14 g
    Soy Lecithin 0.1 g
  • The above ingredients were admixed and shaken until homogeneous blend was obtained. The blended composition was poured into 250 mL of water, mixed and then consumed via drinking.
  • Example 6
  • Ingredient Amount
    Fish Oil 70 mg
    Selenium (from Selenium yeast) 2500 mcg
    Beta Carotene 1000 iu
    Vitamin D3 100 iu
    Vitamin K 15 mcg
    Vitamin B6 0.5 mg
    Vitamin B12 1 mcg
    Folic Acid 250 mcg
    Zinc 5.0 mg
    Chromium 25 mcg
    Molybdenum 15 mcg
    Glutamine 20 g
    Argenine 5.1 g
    Taurine 3.2 g
    Lysine 7.3 g
    CoQ-10 50 mg
    Biotin 2 mg
    Calcium 200 mg
    Iron 3 mg
    Phosphourous 213 mg
    Iodine 35 mg
    Copper 500 mcg
    Manganese 570 mcg
    Inositol 1.2 g
    Sucrose 3.5 g
    Whey Protein Isolate 0.75 g
    Rice Protein 0.23 g
    Calcium Caseinate 0.14 g
    Soy Lecithin 0.1 g
  • The above ingredients were admixed and shaken until homogeneous blend was obtained. The blended composition was poured into 250 mL of water, mixed and then consumed via drinking.

Claims (14)

What is claimed is:
1. A nutritional composition suitable for oral consumption by the human system comprising selenium in the form of selenium yeast together with a fish oil preparation.
2. The composition of claim 1 with Resverotrol extract.
3. The composition of claim 2 with naturally occurring Beta-carotene preparation.
4. The composition of claim 3 with vitamin D3.
5. The composition of claim 4 with the vitamin K, vitamin B6, folic acid, and Coenzyme Q-10.
6. The composition of claim 5 with the addition of the minerals Zinc, Chromium, Molybdenum.
7. The composition of claim 6 with the addition of the amino acids Glutamine, Argenine, Taurine, Lysine.
8. A nutritional composition suitable for oral consumption by the human system comprising selenium in the form of selenium yeast having from between 25 mg to 150 mcg of selenium yeast preparation together with a fish oil preparation of between 350 mg to 750 mg, comprising 30%-65% of the fatty acids EPA and DHA where the preferred ratio of EPA to DHA is about 3 parts EPA to 2 parts DHA.
9. The composition of claim 8 with Resverotrol extract, where the amount of the Resverotrol extract is between about 50 mg-150 mg.
10. The composition of claim 9 with naturally occurring Beta-carotene preparation comprising from 1000 iu to 3000 iu.
11. The composition of claim 10 with addition of 100 iu to 25 iu of vitamin D3.
12. The composition of claim 11 with the addition of vitamin K, vitamin B6, folic acid, and Coenzyme Q-10.
13. The composition of claim 12 with the addition of the minerals Zinc, Chromium, Molybdenum.
14. The composition of claim 13 with the addition of the amino acids Glutamine, Argenine, Taurine, Lysine.
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KR20200092939A (en) * 2017-09-19 2020-08-04 로.리. 파르마 에스.알.엘 Compositions, uses and methods for treating infertility and infertility
KR102468673B1 (en) * 2017-09-19 2022-11-17 로.리. 파르마 에스.알.엘 Compositions, uses and methods for infertility and infertility treatment
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US20220062388A1 (en) * 2017-09-19 2022-03-03 Lo.Li. Pharma S.R.L. Compositions, uses and methods for treatment of infertility and subfertility
IT201700104446A1 (en) * 2017-09-19 2019-03-19 Lo Li Pharma Srl Compositions, uses and methods for the treatment of infertility and subfertility
CN114072155A (en) * 2019-04-01 2022-02-18 豪恩·西蒙·夏 Compositions and methods for cancer immunotherapy

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US10946052B2 (en) 2021-03-16
US11576940B2 (en) 2023-02-14
US20210283205A1 (en) 2021-09-16
US20190038687A1 (en) 2019-02-07
US20230113424A1 (en) 2023-04-13
US10653733B2 (en) 2020-05-19
US10117902B2 (en) 2018-11-06
US20160317593A1 (en) 2016-11-03
US20200276254A1 (en) 2020-09-03
US11253561B2 (en) 2022-02-22

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