US20110120185A1 - Methods for producing sterile cryogenic fluids - Google Patents
Methods for producing sterile cryogenic fluids Download PDFInfo
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- US20110120185A1 US20110120185A1 US12/674,502 US67450208A US2011120185A1 US 20110120185 A1 US20110120185 A1 US 20110120185A1 US 67450208 A US67450208 A US 67450208A US 2011120185 A1 US2011120185 A1 US 2011120185A1
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- 239000012530 fluid Substances 0.000 title claims abstract description 58
- 238000000034 method Methods 0.000 title claims abstract description 49
- 239000007789 gas Substances 0.000 claims abstract description 60
- 239000002912 waste gas Substances 0.000 claims abstract description 41
- 238000001914 filtration Methods 0.000 claims abstract description 39
- 238000004519 manufacturing process Methods 0.000 claims abstract description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 78
- 239000007788 liquid Substances 0.000 claims description 44
- 229910052757 nitrogen Inorganic materials 0.000 claims description 38
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 18
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 10
- 239000001301 oxygen Substances 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 239000003570 air Substances 0.000 claims description 9
- 229910052786 argon Inorganic materials 0.000 claims description 9
- 244000005700 microbiome Species 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 10
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 9
- 239000003814 drug Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 5
- 238000003860 storage Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000000135 prohibitive effect Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J3/00—Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification
- F25J3/08—Separating gaseous impurities from gases or gaseous mixtures or from liquefied gases or liquefied gaseous mixtures
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J1/00—Processes or apparatus for liquefying or solidifying gases or gaseous mixtures
- F25J1/0002—Processes or apparatus for liquefying or solidifying gases or gaseous mixtures characterised by the fluid to be liquefied
- F25J1/0012—Primary atmospheric gases, e.g. air
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J1/00—Processes or apparatus for liquefying or solidifying gases or gaseous mixtures
- F25J1/0002—Processes or apparatus for liquefying or solidifying gases or gaseous mixtures characterised by the fluid to be liquefied
- F25J1/0012—Primary atmospheric gases, e.g. air
- F25J1/0015—Nitrogen
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J1/00—Processes or apparatus for liquefying or solidifying gases or gaseous mixtures
- F25J1/0002—Processes or apparatus for liquefying or solidifying gases or gaseous mixtures characterised by the fluid to be liquefied
- F25J1/0012—Primary atmospheric gases, e.g. air
- F25J1/0017—Oxygen
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J1/00—Processes or apparatus for liquefying or solidifying gases or gaseous mixtures
- F25J1/0002—Processes or apparatus for liquefying or solidifying gases or gaseous mixtures characterised by the fluid to be liquefied
- F25J1/0012—Primary atmospheric gases, e.g. air
- F25J1/002—Argon
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J1/00—Processes or apparatus for liquefying or solidifying gases or gaseous mixtures
- F25J1/02—Processes or apparatus for liquefying or solidifying gases or gaseous mixtures requiring the use of refrigeration, e.g. of helium or hydrogen ; Details and kind of the refrigeration system used; Integration with other units or processes; Controlling aspects of the process
- F25J1/0221—Processes or apparatus for liquefying or solidifying gases or gaseous mixtures requiring the use of refrigeration, e.g. of helium or hydrogen ; Details and kind of the refrigeration system used; Integration with other units or processes; Controlling aspects of the process using the cold stored in an external cryogenic component in an open refrigeration loop
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/022—Filtration
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2205/00—Processes or apparatus using other separation and/or other processing means
- F25J2205/84—Processes or apparatus using other separation and/or other processing means using filter
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2210/00—Processes characterised by the type or other details of the feed stream
- F25J2210/02—Multiple feed streams, e.g. originating from different sources
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2210/00—Processes characterised by the type or other details of the feed stream
- F25J2210/40—Air or oxygen enriched air, i.e. generally less than 30mol% of O2
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2210/00—Processes characterised by the type or other details of the feed stream
- F25J2210/42—Nitrogen
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2210/00—Processes characterised by the type or other details of the feed stream
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2210/00—Processes characterised by the type or other details of the feed stream
- F25J2210/58—Argon
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2215/00—Processes characterised by the type or other details of the product stream
- F25J2215/40—Air or oxygen enriched air, i.e. generally less than 30mol% of O2
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2215/00—Processes characterised by the type or other details of the product stream
- F25J2215/42—Nitrogen or special cases, e.g. multiple or low purity N2
- F25J2215/44—Ultra high purity nitrogen, i.e. generally less than 1 ppb impurities
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2215/00—Processes characterised by the type or other details of the product stream
- F25J2215/50—Oxygen or special cases, e.g. isotope-mixtures or low purity O2
- F25J2215/56—Ultra high purity oxygen, i.e. generally more than 99,9% O2
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2215/00—Processes characterised by the type or other details of the product stream
- F25J2215/58—Argon
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2270/00—Refrigeration techniques used
- F25J2270/90—External refrigeration, e.g. conventional closed-loop mechanical refrigeration unit using Freon or NH3, unspecified external refrigeration
- F25J2270/904—External refrigeration, e.g. conventional closed-loop mechanical refrigeration unit using Freon or NH3, unspecified external refrigeration by liquid or gaseous cryogen in an open loop
Definitions
- the present invention provides for a method for producing sterile cryogenic fluids, such as sterile liquid by utilizing a waste gas stream from a heat exchanger as the sterile cryogenic fluid feedstock.
- Cryogenic liquid nitrogen is increasingly being used to enhance drug production in the pharmaceutical and biotechnology industry. If the liquid nitrogen is not sterile, it cannot be used as a direct contact coolant in the preparation of final preparation of pharmaceuticals products such as antibiotics or vaccines. In addition cryogenic storage facilities have also fallen under scrutiny concerning the sterility of Liquid Nitrogen.
- the method of sterilization of a warm gas is by filtration to remove micro-organisms or other particulates whose size are generally greater than 0.2 ⁇ m.
- Sterile cryogenic fluids which are typically liquid nitrogen have been produced by two techniques where the method of sterilization is typically filtration.
- the first method is direct liquid filtration
- the second method is to filter ambient temperature (warm) gas in a standard filtration unit, then liquefy the sterile (warm) gas to produce sterile cryogenic liquid.
- U.S. Pat. No. 4,620,962 teaches that liquid nitrogen is split into two paths.
- the first stream passes through two heat exchangers and a (warm) filter for the production of sterile liquid nitrogen.
- the second stream is de-pressurized (to produce a colder liquid) and used to re-liquefy the first stream in the second of the heat exchangers.
- the overall liquid nitrogen consumption is about two times the amount of sterile liquid nitrogen produced.
- the amount of sterile cryogenic liquid produced is less than the amount of cryogenic liquid fed to the filtration system.
- the present invention provides for the production of a sterile cryogenic fluid through warm filtration while significantly reducing the amount of cryogenic fluid consumed.
- the present invention provides for a method for producing sterile cryogenic fluids by feeding a gas to be sterilized to a filtration system, thereby producing a sterile warm gas; feeding the sterile warm gas to a heat exchanger where it will contact a second stream of liquid, thereby cooling and condensing the sterile warm gas to produce a sterile liquid, and withdrawing the sterile liquid, the improvement comprising directing the warm waste gas stream from the heat exchanger to a second filtration unit to produce a sterile waste gas stream and feeding the sterile waste gas stream to a second heat exchanger to produce sterile cryogenic fluid by contact with a stream of liquid.
- the present invention further provides for an improved method for producing sterile cryogenic fluids by feeding a warm gas stream to be sterilized to a filtration system to produce a sterile warm gas stream and feeding the sterile warm gas stream to a heat exchanger thereby cooling and condensing the sterile warm gas stream to produce a sterile liquid, the improvement comprising feeding the warm waste gas stream from the heat exchanger to a second filtration system for producing sterile warm gas.
- the warm gas streams are generally at or near ambient temperatures of about ⁇ 40° C. to +40° C.
- the present invention provides for a method for producing a sterile cryogenic fluid comprising feeding a waste gas stream from a first heat exchanger to a filtration system thereby producing a warm sterile gas and feeding the warm sterile gas to a second heat exchanger wherein the warm sterile gas is reduced to cryogenic temperature.
- the gas stream that is fed to the filtration unit is typically a cryogenic fluid having a normal boiling point below ⁇ 50° C. and can be selected from the group consisting of nitrogen, oxygen, air and argon. Mixtures of cryogenic fluids, such as oxygen/nitrogen mixtures, are suitable cryogenic fluids. It is recognized that “fluids” can be either a gas or liquid having a normal boiling point below ⁇ 50° C.
- the filtration system removes microorganisms and other particulates from said gas stream while the heat exchanger will use cryogenic fluids to provide heat exchange with the sterilized gas stream.
- the waste gas stream that leaves the heat exchanger is a cryogenic fluid selected from the group consisting of nitrogen, oxygen, air and argon.
- the waste gas stream and the gas stream can be either the same type of cryogenic fluids or they may be different.
- the present invention provides for using the warm waste gas stream from the liquefaction step of the sterilization process as the warm feed stream for a second sterilization process.
- the inventive process may be modularized and a third or any number of additional modules may be added recognizing the constraints of pressure control throughout the modules. For example, a sterilized waste gas stream from a third heat exchanger may be fed to a third filtration unit.
- the present invention will allow for the use of liquid nitrogen in key areas in drug production where it was formerly prohibitive to use liquid nitrogen due to contamination vector issues for introducing micro-organisms. This invention will also improve the overall efficiency of the sterilization process, particularly when two or more filtration unit/heat exchanger systems are employed.
- FIG. 1 is a schematic diagram of a process for sterilizing a cryogenic fluid employing a filtration unit and a heat exchange unit.
- FIG. 2 is a schematic diagram of the present invention for producing a sterile cryogenic fluid by directing the warm waste gas stream from a first module to the feed stream of a second module.
- FIG. 3 is a schematic diagram of the present invention for producing a sterile cryogenic fluid showing the use of three modules.
- FIG. 1 there is depicted a method for producing a sterile liquid fluid.
- liquid nitrogen will be employed in the description but other gases that are capable of being sterilized may also be employed in the methods of the present invention.
- Warm nitrogen gas WG at a pressure P 1 is delivered through line 1 and is filtered by filtration unit F to produce sterile warm gas SWG.
- the filtration process using widely accepted filtration methods for gaseous nitrogen, removes microorganisms such as virus, bacteria and fungi.
- This sterile warm gas SWG directed through line 2 and is then liquefied in a heat exchanger C, of conventional design appropriate for cryogenic operation using a separate stream of liquid nitrogen LN at a pressure P 2 fed into the heat exchanger through line 4 .
- Suitable heat exchangers include plate fin type compact heat exchangers.
- P 2 must be lower than P 1 in order to satisfy the thermodynamic requirement for condensing the sterile warm gas. That requirement is that the saturation temperature at P 1 must be higher by about 5° C. than the saturation temperature at P 2 . This means that P 2 will be about 1 to 3 bar (14.5 to 43.5 psi) lower in pressure depending on the value of P 1 . For example, if P 1 is 10 barg, then P 2 would need to be about 6.9 barg (3.1 bar pressure difference) for a 5° C. temperature difference between the two corresponding saturation temperatures. If P 1 is 3 barg, then P 2 would need to be about 1.6 barg or 1.4 bar difference in pressure for the same 5° C. temperature difference between the two corresponding saturation temperatures.
- the sterile liquid nitrogen SLN will exit the heat exchanger C through line 3 where it may be recovered and used or stored for later use.
- the warm waste gas stream WG at pressure P 2 exits the heat exchanger C through line 5 where it may be recovered for reuse elsewhere or, more typically, is by release into the atmosphere.
- the ratio of liquid nitrogen LN used to the amount of sterile liquid nitrogen SLN produced in the system illustrated in FIG. 1 is typically a number somewhat greater than 1.
- a ratio of about 1.1 is typical.
- a ratio of 1.0 will be used.
- the total nitrogen used is two times the amount of sterile liquid nitrogen produced.
- FOM Amount ⁇ ⁇ of ⁇ ⁇ nitrogen ⁇ ⁇ consumed Amount ⁇ ⁇ of ⁇ ⁇ sterile ⁇ ⁇ ⁇ liquid ⁇ ⁇ nitrogen ⁇ ⁇ produced - 1
- the solution FOM is a dimensionless measure of the excess fluid (warm or cryogenic) required to produce a given amount of sterile cryogenic liquid, and will typically range between 0 and 1. For the system shown in FIG. 1 , the FOM is about 1.0. The lower the FOM, the more efficient the system.
- FIG. 2 describes the present invention for reducing the amount of nitrogen required in the process.
- Two modules of similar construction are connected as shown. The first module works as described above in FIG. 1 .
- Warm gas WG at a pressure P 1 is directed through line 1 into an appropriate filtration unit F and sterile warm gas SWG is fed into a heat exchanger C through line 2 where it will contact liquid nitrogen LN fed through line 4 at a lower pressure P 2 than the WG and a sterile liquid nitrogen SLN stream is produced.
- the SLN at P 1 is recovered via line 3 .
- the warm waste gas stream WG which is also at pressure P 2 is fed through line 5 to a second filtration unit F 2 which produces the sterile warm gas SWG which is fed through line 6 to a second heat exchanger C 2 and produces the sterile liquid nitrogen SLN at pressure P 2 which is then recovered through line 7 .
- Liquid nitrogen LN at pressure P 3 which is lower than P 1 and P 2 contacts the SWG through line 8 and the warm waste gas WG exits the heat exchanger C 2 through line 9 at a pressure P 3 .
- the pressure of the liquid nitrogen LN in each of the heat exchangers must be lower than the pressure of the corresponding sterile warm gas SWG.
- FIG. 3 describes a system where a third module may be added to that described in FIG. 2 .
- the description of the operation of the first two modules is the same as that described above for FIG. 2 .
- the warm waste gas WG that leaves the second heat exchanger C 2 through line 9 enters the filtration unit F 3 at pressure P 3 .
- the sterile warm gas SWG enters the third heat exchanger C 3 through line 10 and contacts the liquid nitrogen LN introduced through line 12 at pressure P 4 to produce the sterile liquid nitrogen SLN at pressure P 3 .
- the warm waste gas WG will exit the heat exchanger C 3 at pressure P 4 through line 13 while the SLN at P 3 will be recovered through line 11 .
- cryogenic fluid i.e., those having a normal boiling point below ⁇ 50° C.
- oxygen, liquid air and argon may be employed in the methods of the present invention.
- the method for warm sterilization may be by filtration with filters having a pore size typically of about 0.2 micron or less but it may also be any combination of filtration with other treatment technologies.
- the cryogenic and ambient temperature fluid sources may be from single or multiple storage tanks or processes.
- a single pressured cryogenic liquid storage tank may be used to supply cryogenic liquid and warm vapor to the sterilization modules at various pressures and flow rates.
- the pressure regulation devices and flow control valves are not show but would be typical for the processes so described and known to those of ordinary skill in the art.
- the individual stream flows may also be modified within the scope of the present invention.
- additional vent streams may be added to improve flow control and balance the heat transfer requirements of the system.
- Provisions may be made to allow individual modules to operate without interaction at times or during start-up of the system.
- Additional heaters or ambient vaporizers may be added to perform additional warming or vaporization of the cryogenic fluids.
- the outlet gas (WG) from the heat exchangers shown in FIGS. 1 to 3 may still be too cold for use in subsequent process steps, e.g., filtration.
- the initial input of warm gas to the first module will typically come from a cryogenic liquid storage tank and will need to be vaporized and warmed.
- Additional components may be added to the system to accomplish steam sterilization or similar processes in order to prepare the system for operation.
- the clean but not sterile vent (waste) gas (WG) from the process may also be used for other purposes.
- warm, pressurized nitrogen gas may be used for a variety of purposes such as tank inerting and pressure transfer. Some or all of this vent gas may be fed directly into a common gas use header within a process facility for general use.
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Abstract
A method for producing a sterile cryogenic fluid is disclosed. A warm gas stream is sterilized by filtration and fed to a heat exchanger resulting in a cryogenic sterile fluid being formed. The waste gas stream from the heat exchanger is fed to a second filtration unit and the warm sterile waste gas stream is fed to a second heat exchanger to produce more cryogenic sterile fluid, resulting in a more efficient use of gases employed in the sterilization process.
Description
- The present application claims priority from International Application PCT/US2008/074727 filed Aug. 29, 2008 which claims priority from U.S. Provisional Patent Application 60/966,796 filed Aug. 30, 2007.
- The present invention provides for a method for producing sterile cryogenic fluids, such as sterile liquid by utilizing a waste gas stream from a heat exchanger as the sterile cryogenic fluid feedstock.
- Gases that come into direct contact with pharmaceuticals during the production process have to meet the same high international quality specifications as the drugs themselves under the ICH Q7A and Food and Drug Administration drug policy. Cryogenic liquid nitrogen is increasingly being used to enhance drug production in the pharmaceutical and biotechnology industry. If the liquid nitrogen is not sterile, it cannot be used as a direct contact coolant in the preparation of final preparation of pharmaceuticals products such as antibiotics or vaccines. In addition cryogenic storage facilities have also fallen under scrutiny concerning the sterility of Liquid Nitrogen.
- Typically the method of sterilization of a warm gas is by filtration to remove micro-organisms or other particulates whose size are generally greater than 0.2 μm. Sterile cryogenic fluids which are typically liquid nitrogen have been produced by two techniques where the method of sterilization is typically filtration. The first method is direct liquid filtration, and the second method is to filter ambient temperature (warm) gas in a standard filtration unit, then liquefy the sterile (warm) gas to produce sterile cryogenic liquid. U.S. Pat. No. 4,620,962 teaches that liquid nitrogen is split into two paths. The first stream passes through two heat exchangers and a (warm) filter for the production of sterile liquid nitrogen. The second stream is de-pressurized (to produce a colder liquid) and used to re-liquefy the first stream in the second of the heat exchangers. The overall liquid nitrogen consumption is about two times the amount of sterile liquid nitrogen produced.
- As such it can be seen that in earlier processes, the amount of sterile cryogenic liquid produced is less than the amount of cryogenic liquid fed to the filtration system. The present invention provides for the production of a sterile cryogenic fluid through warm filtration while significantly reducing the amount of cryogenic fluid consumed.
- The present invention provides for a method for producing sterile cryogenic fluids by feeding a gas to be sterilized to a filtration system, thereby producing a sterile warm gas; feeding the sterile warm gas to a heat exchanger where it will contact a second stream of liquid, thereby cooling and condensing the sterile warm gas to produce a sterile liquid, and withdrawing the sterile liquid, the improvement comprising directing the warm waste gas stream from the heat exchanger to a second filtration unit to produce a sterile waste gas stream and feeding the sterile waste gas stream to a second heat exchanger to produce sterile cryogenic fluid by contact with a stream of liquid.
- The present invention further provides for an improved method for producing sterile cryogenic fluids by feeding a warm gas stream to be sterilized to a filtration system to produce a sterile warm gas stream and feeding the sterile warm gas stream to a heat exchanger thereby cooling and condensing the sterile warm gas stream to produce a sterile liquid, the improvement comprising feeding the warm waste gas stream from the heat exchanger to a second filtration system for producing sterile warm gas. The warm gas streams are generally at or near ambient temperatures of about −40° C. to +40° C.
- Alternatively the present invention provides for a method for producing a sterile cryogenic fluid comprising feeding a waste gas stream from a first heat exchanger to a filtration system thereby producing a warm sterile gas and feeding the warm sterile gas to a second heat exchanger wherein the warm sterile gas is reduced to cryogenic temperature.
- In a further embodiment of the present invention, there is disclosed a method for producing a sterile cryogenic fluid comprising the steps:
- a) feeding a waste gas stream from a first heat exchanger unit to a filtration unit, whereby the waste gas stream is sterilized;
b) feeding the sterilized waste gas stream to a second heat exchanger wherein the sterilized waste gas stream is reduced in temperature, thereby producing a sterile cryogenic fluid;
c) recovering the sterile cryogenic fluid; and
d) feeding a second waste gas stream from the second heat exchanger and feeding the second waste gas stream to a second filtration unit whereby the second waste gas stream is sterilized and feeding the second sterilized waste gas stream to a third heat exchanger. - The gas stream that is fed to the filtration unit is typically a cryogenic fluid having a normal boiling point below −50° C. and can be selected from the group consisting of nitrogen, oxygen, air and argon. Mixtures of cryogenic fluids, such as oxygen/nitrogen mixtures, are suitable cryogenic fluids. It is recognized that “fluids” can be either a gas or liquid having a normal boiling point below −50° C.
- The filtration system removes microorganisms and other particulates from said gas stream while the heat exchanger will use cryogenic fluids to provide heat exchange with the sterilized gas stream.
- The waste gas stream that leaves the heat exchanger is a cryogenic fluid selected from the group consisting of nitrogen, oxygen, air and argon. The waste gas stream and the gas stream can be either the same type of cryogenic fluids or they may be different.
- The present invention provides for using the warm waste gas stream from the liquefaction step of the sterilization process as the warm feed stream for a second sterilization process. The inventive process may be modularized and a third or any number of additional modules may be added recognizing the constraints of pressure control throughout the modules. For example, a sterilized waste gas stream from a third heat exchanger may be fed to a third filtration unit.
- The present invention will allow for the use of liquid nitrogen in key areas in drug production where it was formerly prohibitive to use liquid nitrogen due to contamination vector issues for introducing micro-organisms. This invention will also improve the overall efficiency of the sterilization process, particularly when two or more filtration unit/heat exchanger systems are employed.
-
FIG. 1 is a schematic diagram of a process for sterilizing a cryogenic fluid employing a filtration unit and a heat exchange unit. -
FIG. 2 is a schematic diagram of the present invention for producing a sterile cryogenic fluid by directing the warm waste gas stream from a first module to the feed stream of a second module. -
FIG. 3 is a schematic diagram of the present invention for producing a sterile cryogenic fluid showing the use of three modules. - In
FIG. 1 , there is depicted a method for producing a sterile liquid fluid. For purposes of illustration, liquid nitrogen will be employed in the description but other gases that are capable of being sterilized may also be employed in the methods of the present invention. - Warm nitrogen gas WG at a pressure P1 is delivered through line 1 and is filtered by filtration unit F to produce sterile warm gas SWG. The filtration process, using widely accepted filtration methods for gaseous nitrogen, removes microorganisms such as virus, bacteria and fungi. This sterile warm gas SWG directed through line 2 and is then liquefied in a heat exchanger C, of conventional design appropriate for cryogenic operation using a separate stream of liquid nitrogen LN at a pressure P2 fed into the heat exchanger through line 4. Suitable heat exchangers include plate fin type compact heat exchangers.
- P2 must be lower than P1 in order to satisfy the thermodynamic requirement for condensing the sterile warm gas. That requirement is that the saturation temperature at P1 must be higher by about 5° C. than the saturation temperature at P2. This means that P2 will be about 1 to 3 bar (14.5 to 43.5 psi) lower in pressure depending on the value of P1. For example, if P1 is 10 barg, then P2 would need to be about 6.9 barg (3.1 bar pressure difference) for a 5° C. temperature difference between the two corresponding saturation temperatures. If P1 is 3 barg, then P2 would need to be about 1.6 barg or 1.4 bar difference in pressure for the same 5° C. temperature difference between the two corresponding saturation temperatures.
- The sterile liquid nitrogen SLN will exit the heat exchanger C through line 3 where it may be recovered and used or stored for later use. The warm waste gas stream WG at pressure P2 exits the heat exchanger C through line 5 where it may be recovered for reuse elsewhere or, more typically, is by release into the atmosphere.
- The ratio of liquid nitrogen LN used to the amount of sterile liquid nitrogen SLN produced in the system illustrated in
FIG. 1 is typically a number somewhat greater than 1. A ratio of about 1.1 is typical. For purposes of illustration a ratio of 1.0 will be used. In this case, the total nitrogen used is two times the amount of sterile liquid nitrogen produced. As such, -
- The solution FOM is a dimensionless measure of the excess fluid (warm or cryogenic) required to produce a given amount of sterile cryogenic liquid, and will typically range between 0 and 1. For the system shown in
FIG. 1 , the FOM is about 1.0. The lower the FOM, the more efficient the system. -
FIG. 2 describes the present invention for reducing the amount of nitrogen required in the process. Two modules of similar construction are connected as shown. The first module works as described above inFIG. 1 . Warm gas WG at a pressure P1 is directed through line 1 into an appropriate filtration unit F and sterile warm gas SWG is fed into a heat exchanger C through line 2 where it will contact liquid nitrogen LN fed through line 4 at a lower pressure P2 than the WG and a sterile liquid nitrogen SLN stream is produced. The SLN at P1 is recovered via line 3. - The warm waste gas stream WG which is also at pressure P2 is fed through line 5 to a second filtration unit F2 which produces the sterile warm gas SWG which is fed through line 6 to a second heat exchanger C2 and produces the sterile liquid nitrogen SLN at pressure P2 which is then recovered through line 7. Liquid nitrogen LN at pressure P3 which is lower than P1 and P2 contacts the SWG through line 8 and the warm waste gas WG exits the heat exchanger C2 through line 9 at a pressure P3.
- The pressure of the liquid nitrogen LN in each of the heat exchangers must be lower than the pressure of the corresponding sterile warm gas SWG. For this example, suitable pressures would be P1=9 barg, P2=6.1 barg and P3=3.9 barg. These pressure differentials ensure about 5° C. temperature difference between the saturation temperatures in each of the heat exchangers.
-
FIG. 3 describes a system where a third module may be added to that described inFIG. 2 . The description of the operation of the first two modules is the same as that described above forFIG. 2 . The warm waste gas WG that leaves the second heat exchanger C2 through line 9 enters the filtration unit F3 at pressure P3. The sterile warm gas SWG enters the third heat exchanger C3 through line 10 and contacts the liquid nitrogen LN introduced through line 12 at pressure P4 to produce the sterile liquid nitrogen SLN at pressure P3. The warm waste gas WG will exit the heat exchanger C3 at pressure P4 through line 13 while the SLN at P3 will be recovered through line 11. The three module system envisioned inFIG. 3 has an FOM of about 0.33. Suitable operating pressures here are P1=9 barg, P2=6.1 barg, P3=3.9 barg, and P4=2.2 barg. - While liquid nitrogen has been used as the cryogenic fluid for the above discussion, other cryogenic fluids, i.e., those having a normal boiling point below −50° C. such as oxygen, liquid air and argon may be employed in the methods of the present invention.
- The method for warm sterilization may be by filtration with filters having a pore size typically of about 0.2 micron or less but it may also be any combination of filtration with other treatment technologies.
- The cryogenic and ambient temperature fluid sources may be from single or multiple storage tanks or processes. For example, a single pressured cryogenic liquid storage tank may be used to supply cryogenic liquid and warm vapor to the sterilization modules at various pressures and flow rates. The pressure regulation devices and flow control valves are not show but would be typical for the processes so described and known to those of ordinary skill in the art.
- The individual stream flows may also be modified within the scope of the present invention. For example, additional vent streams may be added to improve flow control and balance the heat transfer requirements of the system. Provisions may be made to allow individual modules to operate without interaction at times or during start-up of the system.
- Additional heaters or ambient vaporizers may be added to perform additional warming or vaporization of the cryogenic fluids. For example, the outlet gas (WG) from the heat exchangers shown in
FIGS. 1 to 3 may still be too cold for use in subsequent process steps, e.g., filtration. The initial input of warm gas to the first module will typically come from a cryogenic liquid storage tank and will need to be vaporized and warmed. - Additional components may be added to the system to accomplish steam sterilization or similar processes in order to prepare the system for operation.
- The clean but not sterile vent (waste) gas (WG) from the process may also be used for other purposes. For example, warm, pressurized nitrogen gas may be used for a variety of purposes such as tank inerting and pressure transfer. Some or all of this vent gas may be fed directly into a common gas use header within a process facility for general use.
- While this invention has been described with respect to particular embodiments thereof, it is apparent that numerous other forms and modifications of the invention will be obvious to those skilled in the art. The appended claims in this invention generally should be construed to cover all such obvious forms and modifications which are within the true spirit and scope of the present invention.
Claims (29)
1. An improved method for producing sterile cryogenic fluids by feeding a gas stream to a filtration system to produce a sterile warm gas and feeding said sterile warm gas to a heat exchanger thereby cooling and condensing said sterile warm gas to produce a sterile liquid, the improvement comprising feeding a waste gas stream from said heat exchanger to a second filtration system for producing sterile warm gas.
2. The method as claimed in claim 1 wherein said gas stream is selected from the group consisting of a cryogenic fluid having a normal boiling point below −50° C.
3. The method as claimed in claim 2 wherein said cryogenic fluid is selected from group consisting of nitrogen, oxygen, air and argon, and mixtures thereof.
4. The method as claimed in claim 1 wherein said first and said second filtration system removes microorganisms and other particulates from said gas stream.
5. The method as claimed in claim 1 wherein said heat exchanger employs cryogenic fluids to provide heat exchange.
6. The method as claimed in claim 5 wherein the pressure of said cryogenic fluids to provide heat exchange is less than the pressure of said gas stream.
7. The method as claimed in claim 1 wherein said sterile cryogenic fluids are recovered.
8. The method as claimed in claim 1 wherein said waste gas stream is a cryogenic fluid selected from the group consisting of nitrogen, oxygen, air and argon.
9. The method as claimed in claim 1 wherein said gas stream and said waste gas stream are both cryogenic fluids.
10. The method as claimed in claim 1 further comprising feeding a gas stream from said second filtration system to a second heat exchanger.
11. A method for producing a sterile cryogenic fluid comprising feeding a waste gas stream from a first heat exchanger to a filtration system thereby producing a warm sterile gas and feeding said warm sterile gas to a second heat exchanger wherein said warm sterile gas is reduced to cryogenic temperature.
12. The method as claimed in claim 11 wherein said gas stream is selected from the group consisting of a cryogenic fluids having a normal boiling point below −50° C.
13. The method as claimed in claim 12 wherein said cryogenic fluid is selected from group consisting of nitrogen, oxygen, air and argon, or mixtures thereof.
14. The method as claimed in claim 11 wherein said first and said second filtration system removes microorganisms and particulates from said gas stream.
15. The method as claimed in claim 11 wherein said heat exchanger employs cryogenic fluids to provide heat exchange.
16. The method as claimed in claim 15 wherein the pressure of said cryogenic fluids to provide heat exchange is less than the pressure of said gas stream.
17. The method as claimed in claim 11 wherein said sterile cryogenic fluids are recovered.
18. The method as claimed in claim 11 wherein said waste gas stream is a cryogenic fluid selected from the group consisting of nitrogen, oxygen, air and argon, and mixtures thereof.
19. The method as claimed in claim 11 wherein said gas stream and said waste gas stream are both cryogenic fluids.
20. A method for producing a sterile cryogenic fluid comprising the steps:
a) feeding a waste gas stream from a first heat exchanger unit to a filtration unit, whereby said waste gas stream is sterilized;
b) feeding said sterilized waste gas stream to a second heat exchanger wherein said sterilized waste gas stream is reduced in temperature, thereby producing a sterile cryogenic fluid;
c) recovering said sterile cryogenic fluid; and
d) feeding the waste gas stream from said second heat exchanger to a second filtration unit whereby said second waste gas stream is sterilized and feeding the second sterilized waste gas stream to a third heat exchanger.
21. The method as claimed in claim 20 wherein said gas stream is selected from the group consisting of a cryogenic fluids having a normal boiling point below −50° C.
22. The method as claimed in claim 20 wherein said cryogenic fluid is selected from group consisting of nitrogen, oxygen, air and argon, and mixtures thereof.
23. The method as claimed in claim 20 wherein said first and said second filtration system removes microorganisms from said gas stream.
24. The method as claimed in claim 20 wherein said heat exchanger employs cryogenic fluids to provide heat exchange.
25. The method as claimed in claim 24 wherein the pressure of said cryogenic fluids to provide heat exchange is less than the pressure of said gas stream.
26. The method as claimed in claim 20 wherein said sterile cryogenic fluids are recovered.
27. The method as claimed in claim 20 wherein said waste gas stream is a cryogenic fluid selected from the group consisting of nitrogen, oxygen, air and argon.
28. The method as claimed in claim 20 wherein said gas stream and said waste gas stream are both cryogenic fluids.
29. The method as claimed in claim 20 further comprising feeding a sterilized gas stream from said third heat exchanger to a third filtration unit.
Priority Applications (1)
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US12/674,502 US20110120185A1 (en) | 2007-08-30 | 2008-08-29 | Methods for producing sterile cryogenic fluids |
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US96679607P | 2007-08-30 | 2007-08-30 | |
PCT/US2008/074727 WO2009029749A1 (en) | 2007-08-30 | 2008-08-29 | Methods for producing sterile cryogenic fluids |
US12/674,502 US20110120185A1 (en) | 2007-08-30 | 2008-08-29 | Methods for producing sterile cryogenic fluids |
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US20110120185A1 true US20110120185A1 (en) | 2011-05-26 |
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US12/674,502 Abandoned US20110120185A1 (en) | 2007-08-30 | 2008-08-29 | Methods for producing sterile cryogenic fluids |
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EP (1) | EP2191219B1 (en) |
JP (1) | JP2010538236A (en) |
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AU (1) | AU2008293476A1 (en) |
RU (1) | RU2010111903A (en) |
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US20110277499A1 (en) * | 2010-05-12 | 2011-11-17 | Lee Ron C | Method for producing sterile cryogenic liquid |
US9945611B2 (en) | 2010-08-04 | 2018-04-17 | Ima Life North America Inc. | Bulk freeze drying using spray freezing and agitated drying |
CN103069240B (en) | 2010-08-04 | 2015-06-17 | Ima生命北美股份有限公司 | Bulk freeze drying system and method using spray freezing and stirred drying |
WO2014178058A1 (en) | 2013-05-01 | 2014-11-06 | Fertilesafe Ltd | Devices and methods for producing liquid air |
EP3476404A1 (en) * | 2016-06-24 | 2019-05-01 | Ulvac, Inc. | Germ-free liquefied gas production apparatus |
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US5737926A (en) * | 1997-04-17 | 1998-04-14 | Praxair Technology, Inc. | Cryogenic sterile nitrogen system |
US20050155378A1 (en) * | 2004-01-19 | 2005-07-21 | Gershtein Vladimir Y. | System for supply and delivery of high purity and ultrahigh purity carbon dioxide |
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JPS57204833A (en) * | 1981-06-05 | 1982-12-15 | Toyo Seikan Kaisha Ltd | Manufacture of food sealing vessel |
JPS60134823A (en) * | 1983-12-24 | 1985-07-18 | 大日本印刷株式会社 | Method of filling and packaging liquefied food |
US4620962A (en) | 1985-03-04 | 1986-11-04 | Mg Industries | Method and apparatus for providing sterilized cryogenic liquids |
JPH0780682B2 (en) * | 1990-07-20 | 1995-08-30 | 東芝セラミックス株式会社 | Liquid nitrogen filtration method |
JPH0482689U (en) * | 1990-11-28 | 1992-07-17 | ||
DE4138321C2 (en) * | 1991-11-21 | 1995-05-18 | Herco Kuehltechnik Hermanns Un | Process and plant for the recovery of a sterilizing gas |
GB9523573D0 (en) * | 1995-11-17 | 1996-01-17 | Boc Group Plc | Gas manufacture |
EP0888132B1 (en) * | 1996-02-13 | 2008-09-24 | Ball Packaging Europe GmbH | Device for eliminating contaminants present in a liquid |
JP2001141358A (en) * | 1999-11-17 | 2001-05-25 | Ekika Tansan Kk | Method for recycling liquefied carbonic acid gas |
GB0015123D0 (en) * | 2000-06-20 | 2000-08-09 | Air Prod & Chem | Process and apparatus for removal of volatile compounds from process gases |
US6912859B2 (en) * | 2002-02-12 | 2005-07-05 | Air Liquide Process And Construction, Inc. | Method and apparatus for using a main air compressor to supplement a chill water system |
FR2844039B1 (en) * | 2002-09-04 | 2005-04-29 | Air Liquide | PROCESS AND PLANT FOR PRODUCING OXYGEN AND RARE GASES BY CRYOGENIC AIR DISTILLATION |
-
2008
- 2008-08-29 CN CN200880105562A patent/CN101815916A/en active Pending
- 2008-08-29 RU RU2010111903/06A patent/RU2010111903A/en unknown
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- 2008-08-29 AU AU2008293476A patent/AU2008293476A1/en not_active Abandoned
- 2008-08-29 JP JP2010523149A patent/JP2010538236A/en not_active Withdrawn
- 2008-08-29 US US12/674,502 patent/US20110120185A1/en not_active Abandoned
- 2008-08-29 WO PCT/US2008/074727 patent/WO2009029749A1/en active Application Filing
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US5737926A (en) * | 1997-04-17 | 1998-04-14 | Praxair Technology, Inc. | Cryogenic sterile nitrogen system |
US20050155378A1 (en) * | 2004-01-19 | 2005-07-21 | Gershtein Vladimir Y. | System for supply and delivery of high purity and ultrahigh purity carbon dioxide |
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CN101815916A (en) | 2010-08-25 |
RU2010111903A (en) | 2011-10-10 |
AU2008293476A1 (en) | 2009-03-05 |
EP2191219B1 (en) | 2021-06-23 |
EP2191219A1 (en) | 2010-06-02 |
WO2009029749A1 (en) | 2009-03-05 |
JP2010538236A (en) | 2010-12-09 |
EP2191219A4 (en) | 2017-10-18 |
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