US20060276339A1 - Methods and compositions for increasing the efficacy of biologically-active ingredients - Google Patents

Methods and compositions for increasing the efficacy of biologically-active ingredients Download PDF

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US20060276339A1
US20060276339A1 US10/531,744 US53174403A US2006276339A1 US 20060276339 A1 US20060276339 A1 US 20060276339A1 US 53174403 A US53174403 A US 53174403A US 2006276339 A1 US2006276339 A1 US 2006276339A1
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insecticide
herbicide
fungicide
botanical
organophosphorus
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US10/531,744
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J. Windsor
Stan Roux
Alan Lloyd
Collin Thomas
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University of Texas System
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University of Texas System
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Assigned to BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM reassignment BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WINDSOR, BRIAN J., LLOYD, ALAN M., THOMAS, COLLIN E., ROUX, STAN J.
Assigned to BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM reassignment BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ROUX, STAN J.
Publication of US20060276339A1 publication Critical patent/US20060276339A1/en
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Definitions

  • the present invention relates generally to the fields of cellular biology. More particularly, it concerns methods and compositions for the modulation of cellular sensitivity to biologically-active agents.
  • Symport is a form of coupled movement of two solutes in the same direction across a membrane by a single carrier. Examples of proton and sodium-linked symport systems are found in nearly all living systems. The energetics of the transport event depend on the relative size and electrical nature of the gradient of solutes.
  • Transport processes have been classified on the basis of their energy-coupling mechanisms. Currently there are four classifications: (1) Primary Active Transport which uses either a chemical, light or electrical energy source, (2) Group Translocation which uses chemical energy sources, (3) Secondary Active Transport which uses either a sodium or proton electrochemical gradient energy source, and (4) Facilitated Diffusion which does not require an energy source (Meyers, 1997).
  • Primary Active Transport which uses either a chemical, light or electrical energy source
  • Group Translocation which uses chemical energy sources
  • Secondary Active Transport which uses either a sodium or proton electrochemical gradient energy source
  • Facilitated Diffusion which does not require an energy source
  • Primary active transport refers to a process whereby a “primary” source of energy is used to drive the active accumulation of a solute into or extrusion of a solute from a cell.
  • Transport proteins include P-type ATPases and ABC-type ATPases, as well as V-type and E-type ATPases. These types of transport systems are found in both eukaryotes and prokaryotes.
  • the bacterial ABC-type transporters which are ATP-driven solute pumps, have eukaryotic counterparts.
  • transmembrane solute transport proteins exhibit a common structural motif. The proteins in these families consist of units or domains that pass through the membrane six times, each time as an ⁇ -helix. This has led to the suggestion that many transport proteins share a common evolutionary origin, but this is not true of several distinct families of transport proteins.
  • Two hydrophilic domains or proteins function to couple ATP hydrolysis in the cytoplasm to activate substrate uptake or efflux, and two hydrophobic domains or proteins function as the transmembrane substrate channels. These proteins or protein domains constitute what is referred to as the ABC (ATP-binding cassette) superfamily. Either the two hydrophilic domains or proteins or the two hydrophobic domains or proteins (or both) may exist either as heterodimers or homodimers.
  • each of these constituents is a distinct protein, then either two, three, or four genes will code for them, depending on whether both are homodimers, one is a homodimer and one is a heterodimer, or both are heterodimers, respectively.
  • the best characterized of the eukaryotic proteins included in this family are the multidrug-resistance (MDR) transporter and the cystic fibrosis related chloride ion channel of mammalian cells (cystic fibrosis transmembrane conductance regulator or CFTR) (Meyers, 1997).
  • MDR multidrug-resistance
  • CFTR cystic fibrosis transmembrane conductance regulator
  • Multidrug resistance is a general term that refers to the phenotype of cells or microorganisms that exhibit resistance to different, chemically dissimilar, cytotoxic compounds. MDR can develop after sequential or simultaneous exposure to various drugs. MDR can also develop before exposure to many compounds to which a cell or microorganism may be found to be resistant. MDR which develops before exposure is frequently due to a genetic event which causes the altered expression and/or mutation of an ATP-binding cassette (ABC) transporter (Wadkins and Roepe, 1997). This is true for both eukaryotes and prokaryotes.
  • ABSC ATP-binding cassette
  • Pgp P-glycoprotein
  • MDR1 multidrug resistance protein
  • MDR1 multidrug resistance protein
  • Pgp is a single polypeptide of ⁇ 1280 amino acids with the typical ABC transporter structure profile. Studies have shown that over expression of Pgp is responsible for the ATP-dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells (Abraham et al., 1993).
  • the plant Arabidopsis thaliana encodes an ATP transporter, AtPGP-1, which is a putative Pgp homolog (Dudler and Hertig, 1992).
  • AtPGP-1 an ATP transporter
  • yeast Saccharomyces cerevisiae equivalent of Pgp, STS1 (Bissinger and Kucher, 1994) has been cloned and shown to confer multidrug resistance when over-expressed in yeast, as has the yeast Pdr5p (Kolacskowski et al., 1996).
  • CFTR and SUR are expressed in the lung epithelium and the ⁇ cells of the pancreas, respectively, as well as in other tissues.
  • CFTR functions as a low conductance ATP and cyclic AMP-dependent Cl ⁇ channel that also appears to have additional important functions, such as modulation of epithelial NA + regulation of outwardly rectified chloride channels (Wadkins and Roepe, 1997).
  • Ecto-5′-nucleotidase specifically acts in adenosine salvage pathways, converting AMP to adenosine which is more readily taken up by the cell and utilized as a precursor for ATP production. Therefore, ecto-5′-nucleotidase may be acting in certain MDR cell lines as a mechanism by which the cell circumvents the loss of ATP (due to up-regulated transport proteins which possibly form ATP transport channels) by creating higher levels of adenosine from which the cell can produce ATP. Correspondingly, 63% of MDR cell line variants tested expressed ecto-5′-nucleotidase.
  • yeast which do not have an adenosine salvage pathway (Boyum and Guidotti, 1997), do contain a PGP-like gene called STS 1 (Bissinger and Kucher, 1994). Therefore, since the adenosine salvage pathway is unlikely to be involved in yeast multidrug resistance, other mechanisms are likely to exist.
  • Extracellular phosphatases are generally referred to as ectophosphatases
  • a type of ectophosphatase is ecto-pyrase. Given reports that show the existence of extracellular ATP, one observation regarding ectoapyrase is that it hydrolyzes the extracellular ATP. In fact, work in animal systems has shown that apyrases hydrolyze ATP in the ECM as part of the adenosine salvage pathway conjointly with ecto-5′ ectonucleotidase (Che, 1992).
  • the invention provides a cytotoxic composition comprising an ectophosphatase inhibitor and a cytotoxic agent set forth in Table 1.
  • the cytotoxic agent is selectively cytotoxic.
  • the cytotoxic composition may be further defined as a herbicidal composition and the cytotoxic agent a herbicide, may be further defined as an insecticidal composition and the cytotoxic agent an insecticide, may be further defined as a fungicidal composition and the cytotoxic agent a fungicide and/or may be further defined as an antibiotic composition and the cytotoxic agent an antibiotic.
  • the antibiotic may be from a class selected from the group consisting of Beta-lactam, Semisynthetic penicillin, Clavulanic Acid, Monobactams, Carboxypenems, Aminoglycosides, Glycopeptides, Lincomycins, Macrolides, Polyenes, Rifamycins, Tetracyclines, Semisynthetic, tetracycline and Chloramphenicol.
  • the ectophosphatase inhibitor may be selected from the group consisting of the compounds of formulae I-XX.
  • the invention provides a plant growth regulator composition comprising an ectophosphatase inhibitor and a plant growth regulator agent set forth in Table 1.
  • the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulae I-XX.
  • the invention provides a chemotherapeutic composition
  • a chemotherapeutic composition comprising an ectophosphatase inhibitory compound and a chemotherapeutic agent.
  • the chemotherapeutic agent is a chemotherapeutic agent set forth in Table 3.
  • the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulae I-XX.
  • the invention provides a method of killing or inhibiting the growth of a plant, comprising contacting said plant with an effective amount of a herbicidal composition provided by the invention.
  • the method may be carried out with potentially any plant, including a monocotyledonous plant or a dicotyledonous plant.
  • the invention provides a method of killing or inhibiting the growth of a tumor cell, comprising contacting said tumor cell with an effective amount of a chemotherapeutic composition of the invention.
  • contacting may comprise administering the composition to a patient in need thereof, wherein the patient comprises the tumor cell.
  • the invention provides a method of killing or inhibiting the growth of a target cell, comprising contacting said cell with a composition formulated therefore.
  • the cell may be a fungal cell, bacterial cell, or insect cell.
  • the invention provides a method of increasing the effectiveness of a cytotoxic agent, comprising admixing said cytotoxic agent with an ectophosphatase inhibitor, wherein the cytotoxic agent is selected from the group set forth in Table 1.
  • the cytotoxic agent may be further defined as a herbicide, insecticide, fungicide, and an antibiotic.
  • antibiotics include those from the following classes: Beta-lactam, Semisynthetic penicillin, Clavulanic Acid, Monobactams, Carboxypenems, Aminoglycosides, Glycopeptides, Lincomycins, Macrolides, Polyenes, Rifamycins, Tetracyclines, Semisynthetic, tetracycline and Chloramphenicol.
  • a cytotoxic agent is a chemotherapeutic agent, for example, selected from the group set forth in Table 3.
  • FIGS. 1A-1C Expression of apyrase in pea and in transgenic plants
  • FIG. 1A Immunoblot analysis of subcellular fractions from etiolated pea plants.
  • FIG. 1B Top, the total phosphate accumulated in the shoots of three independent transgenic plants. Bottom, a corresponding Immunoblot performed on protein from ECM of wild-type and transgenic plants.
  • FIG. 1C Assay of phosphatase activity in the ECM fraction of OE1 and wild-type.
  • FIGS. 2 A-C Transport of the products of ATP hydrolysis by transgenic plants overexpressing apyrase and by wild-type plants.
  • FIGS. 3 A-D Conference of resistance to cycloheximide ( FIG. 3A , B) and nigencin ( FIG. 3C , D) in wild-type and ectophosphatase deficient yeast over-expressing the Arabidopsis plant ABC transporter, AtPGP-1.
  • FIGS. 4 A-B- 3 Conference of resistance to cycloheximide ( FIG. 4A ) and cytokinin ( FIG. 4B - 1 - FIG. 4B-3 ) in Arabidopsis plants over-expressing either the ectophosphatase, apyrase, or the ABC transporter, AtPGP-1.
  • FIGS. 5 A-B Graph showing the growth turbidity of YMR4 yeast over-expressing the Arabidopsis plant ABC transporter AtPGP-1 grown in cycloheximide ( FIG. 5A ) or nigericin ( FIG. 5B ).
  • FIG. 6 Graph showing germination rate of Arabidopsis plants grown in the presence of cycloheximide which over-express either the ectophosphatase, apyrase, or the ABC transporter AtPGP-1.
  • FIG. 7 Graph of steady-state levels of ATP in the extracellular fluid of wildtype yeast cells grown in the presence or absence of glucose and in the presence or absence of over-expression of the Arabidopsis plant ABC transporter, AtPGP-1.
  • FIG. 8 Graph showing that over-expression of Arabidopsis plant ABC transporter, AtPGP-1, in yeast can double the steady-state levels of ATP in the extracellular fluid.
  • FIG. 9 Graph showing that a yeast mutant, YMR4, that has a deficient ectophosphatase, accumulates ATP in the extracellular fluid and the over-expression of AtPGP-1 increases the accumulation of ATP.
  • FIG. 10 Graph showing results of a pulse-chase experiment in either wildtype yeast cells or a yeast mutant, YMR4, which is deficient in ectophosphatase activity, in the presence and absence of over-expression of Arabidopsis plant ABC transporter, AtPGP-1, demonstrating an early differential ATP efflux of cells over-expressing AtPGP-1.
  • FIG. 11 Graph of ATP levels on the surface of leaves of Arabidopsis plants over-expressing AtPGP-1 (MDR 1).
  • FIG. 12 Effects of phosphatase inhibitor in wild-type and AtPGP-1 (MDRI) overexpressing Arabidopsis plants.
  • FIG. 13 Growth effects of cycloheximide and extracellular ATP on wildtype and MDR1 overexpressing S. cerevisiae yeast cells which have either never seen cycloheximide or which have been previously selected in cycloheximide.
  • FIG. 14 Growth effects of cycloheximide, adenosine and phosphate on wildtype and AtPGP-1 overexpressing S. cerevisiae yeast cells.
  • the present invention provides methods and compositions for modulating the sensitivity of cells to cytotoxic compounds and other active agents.
  • modulation may be carried out by modifying cellular ATP gradients, for example, by contacting a plant, animal, yeast or bacterial cell with an ectophosphatase inhibitor contemporaneously with a cytotoxic agent or other active ingredient, or combinations thereof.
  • ectophosphatase inhibitor refers to a compound that has the ability to specifically inhibit ectophosphatase activity.
  • a “cytotoxic agent” is a compound capable of selectively or non-selectively killing or inhibiting the growth of a cell, including antibiotics, fungicides, herbicides, insecticides and chemotherapeutic agents.
  • the efficacy of one or more cytotoxic agents may be increased in accordance with the invention by reducing the ATP gradient across biological membranes, which is effectuated through the modulation of an ectophosphatase either alone or together with an ABC transporter molecule.
  • Modulation of resistance to a cytotoxic compound as described herein is useful, for example, in increasing the sensitivity of plants to herbicides; reducing drug resistance in tumor cells for improved chemotherapy applications; and reducing resistance to antibiotics, antifungal agents, insecticides and other cytotoxic agents for the treatment of infections and disease.
  • Provided by the invention are specific combinations of ectophosphatase inhibitors and cytotoxic compounds or other active ingredients that may be used in these applications.
  • the manipulation of extracellular ATP levels to alter ATP gradient across biological membranes in cells by inhibition of ectophosphatases results in diminishing or removing the ATP gradient that may otherwise prevent access of cytotoxic agents to the cell.
  • access may be minimized by efflux of cytotoxic agents from the cell. This efflux is likely effectuated through the “piggy-back” efflux of drug molecules with ATP, a phenomenon known as symport.
  • inhibitors of ectophosphatases may be administered contemporaneously with cytotoxic agents, including herbicides, antibiotics, fungicides, insecticides and other active ingredients, as well as chemotherapeutics.
  • cytotoxic agents including herbicides, antibiotics, fungicides, insecticides and other active ingredients, as well as chemotherapeutics.
  • cytotoxic agents including herbicides, antibiotics, fungicides, insecticides and other active ingredients, as well as chemotherapeutics.
  • cytotoxic agents including herbicides, antibiotics, fungicides, insecticides and other active ingredients, as well as chemotherapeutics.
  • cytotoxic agents including herbicides, antibiotics, fungicides, insecticides and other active ingredients, as well as chemotherapeutics.
  • ectophosphatase inhibitors are used as adjuvants with cytotoxic agents, that is, are admixed with one or more cytotoxic agents or other active ingredients.
  • physiological compositions for modulating cell growth and/or survival, including, but not limited to, MDR cells.
  • physiological compositions may comprise a small molecule capable of inhibiting an ectophosphatase and a physiologically acceptable carrier or diluent together with a therapeutic agent.
  • physiologically acceptable carrier or diluent means any and all solvents, dispersion media, antibacterial and antifungal agents, microcapsules, liposomes, cationic lipid carriers, isotonic and absorption delaying agents and the like which are not incompatible with the ectophosphatase inhibitors.
  • physiologically acceptable carrier or diluent means any and all solvents, dispersion media, antibacterial and antifungal agents, microcapsules, liposomes, cationic lipid carriers, isotonic and absorption delaying agents and the like which are not incompatible with the ectophosphatase inhibitors.
  • Supplementary active ingredients may also be incorporated into the compositions.
  • the ectophosphatase is human apyrase. In other embodiments, the ectophosphatase is a plant, bacterial, fungal or yeast ectophosphatase.
  • the inhibition of ectophosphatases is useful in increasing sensitivity to cytotoxic agents and/or reduction of drug resistance in cells.
  • the inhibition of ectophosphatases results in a loss of resistance to a cytotoxic agent.
  • administration of such inhibitory molecules is in conjunction with the administration of chemotherapeutic agents in tumor cells.
  • ectophosphatase inhibitors may be isolated, for example, by screening a small molecule library (e.g. a combinatorial library) for inhibitory activity to ectophosphatase (e.g. apyrase activity). Once ectophosphatase inhibitory molecules are isolated from such a screen, the inhibitors may be further tested for their ability to specifically inhibit the ATPase activity of the ectophosphatase.
  • a small molecule library e.g. a combinatorial library
  • Exemplary ectophosphatase inhibitory molecules for use with the current invention are preferably chemically stable and physiologically active including, but not limited to, the compounds of formulae I-XX.
  • the ectophosphatase inhibitory molecules are useful in increasing the activities of various agents by increasing the availability of the agents to cells.
  • this may comprise reversing multidrug resistance (MDR) in an organism.
  • MDR multidrug resistance
  • this may be achieved with a cell that does not exhibit MDR.
  • Such cells may or may not comprise an up-regulated ectophosphatase
  • MDR reversal and/or increasing of sensitivity to a cytotoxic agent in cells may be shown by growing the cells in the presence of relevant drugs and in the presence and absence of the inhibitor. Cells which cannot grow in the presence of a drug in the presence of an ectophosphatase inhibitor, have a reversal in MDR and/or increase in sensitivity to the agent.
  • the ectophosphatase inhibitory compositions of the present invention are useful in reversing drug resistance in mammalian cell lines grown in the presence of a drug (e.g. a chemotherapeutic agent).
  • a drug e.g. a chemotherapeutic agent
  • Analysis of sensitivity to a chemotherapeutic composition in mammalian cells may be shown, for example, by using the fluorescent compound calcein-AM. Esterases present in cells cleave the aceto-methoxy ester (AM) from the calcein-AM and liberate calcein.
  • Calcein is a fluorescent compound which is excitable by the 488 nm laser of a FACS Caliber flow cytometer (Becton Dickenson, Franklin Lakes, N.J.), while the uncleaved calcein-AM is not excitable. Wild type cells incubated in the presence of calcein-AM show a high level of fluorescence while MDR state cells, which efflux the calcein-AM faster than the cellular esterases can cleave it, do not show a high level of fluorescence.
  • the mammalian cells can be tested for the reversal of MDR with ectophosphatase inhibitors by the amount of calcein fluorescence detected in the cells.
  • ectophosphatase inhibitors may be tested with the screening assays described herein. Inhibitors can be tested for their ability to inhibit acid phosphatases, alkaline phosphatases, myosin phosphatases and the luciferase ATPase.
  • the assays may be performed using techniques known in the art.
  • the ectophosphatase is an apyrase and the ectophosphatase inhibitor is a molecule selected from among molecules represented by the Formulae I through XX.
  • the ectophosphatase is apyrase and the ectophosphatase inhibitor is a molecule selected from among molecules represented by the Formulae I through V.
  • the ectophosphatase is apyrase and the ectophosphatase inhibitor is a molecule represented by Formula XX.
  • Formula XX is suramin or 8,8′[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl imino]]bis-1,3,5-naphthalenetrisulfonic acid.
  • Suramin has been reported as a potent non-competitive inhibitor of ectoapyrase activity associated with the plasma membrane of cholinergic nerve terminal of Torpedo mannorata electric organs (arti et al., 1996).
  • an ectophosphatase inhibitor may inhibit an ectophosphatase active on the outer membrane of an organelle of a eukaryotic cell. In this manner, contacting the cell with the ectophosphatase inhibitor may be used to decrease the ATP gradient across the organelle and thereby facilitate uptake of a biologically active agent by the organelle.
  • Ectophosphatase inhibitor compositions which may be acidic or basic in nature, can form a wide variety of salts with various inorganic and organic bases or acids, respectively. These salts may be physiologically acceptable for in vivo administration in mammals, including humans, as well as formulations for ex vivo applications, including agricultural use. Salts of acidic compounds are readily prepared by treating the acidic compound with an appropriate molar quantity of the chosen inorganic or organic base in an aqueous or suitable organic solvent and then evaporating the solvent to obtain the salt. Salts of basic compounds can be obtained similarly by treatment with the desired inorganic or organic acid and subsequent solvent evaporation and isolation. The skilled artisan can produce salts of ectophosphatase inhibitors using techniques known in the art.
  • ectophosphatase inhibitor that is required to inhibit ectophosphatase by measuring ATPase activity in the presence and absence of varying amounts of the inhibitor.
  • Phosphatase activity can be determined by assessing the dephosphorylation of ATP and liberation of phosphate as described herein.
  • parameters may be measured that are known to be associated with ectophosphatase activity to determine whether the molecule has ectophosphatase inhibitory activity.
  • ectophosphatase inhibitory activity may be measured in cells (e.g., yeast, plant, bacterial, mammalian, and tumor cell lines) by assessing the loss of resistance to drugs.
  • ectophosphatase inhibitory molecules of the present invention may be tested for specific inhibitory activity to ectophosphatases versus general phosphatases or for specific inhibitory activity for a particular ectophosphatase activity (e.g., apyrase).
  • compositions comprising an ectophosphatase inhibitor, a cytotoxic agent or other active ingredient and a physiologically acceptable carrier or diluent.
  • compositions are provided comprising one or more ectophosphatase inhibitor and one or more plant growth regulator, herbicide, fungicide, insecticide, antibiotic, chemotherapeutic agent or other active compound.
  • the ectophosphatase is selected from the compounds of formulae I-XX in the appropriate carriers, diluents or other active ingredients.
  • compositions of the invention suitable for administration include sterile aqueous solutions or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersions.
  • Typical carriers include a solvent or dispersion medium containing, for example, water buffered aqueous solutions (i.e., biocompatible buffers), ethanol, polyols such as glycerol, propylene glycol, polyethylene glycol, suitable mixtures thereof, surfactants, and vegetable oils.
  • Isotonic agents such as sugars or sodium chloride may be incorporated into the subject compositions.
  • compositions in accordance with the invention may be used by themselves or in combination with other forms active ingredients or therapeutics.
  • One embodiment of the invention provides formulations for parenteral administration, e.g., formulated for injection via the intravenous, intramuscular, sub-cutaneous or other such routes.
  • parenteral administration e.g., formulated for injection via the intravenous, intramuscular, sub-cutaneous or other such routes.
  • such compositions can be prepared as injectables, either as liquid solutions or suspensions; solid forms suitable for using to prepare solutions or suspensions upon the addition of a liquid prior to injection also can be prepared; and the preparations also can be emulsified.
  • Solutions of the active compounds as free base or pharmacologically acceptable salts can be prepared in water suitably mixed with a surfactant, such as hydroxypropylcellulose. Dispersions also can be prepared in glycerol, liquid polyethylene glycols, and mixtures thereof and in oils. Under ordinary conditions of storage and use, these preparations contain a preservative to prevent the growth of microorganisms.
  • the pharmaceutical forms suitable for injectable use include sterile aqueous solutions or dispersions; formulations including sesame oil, peanut oil or aqueous propylene glycol; and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersions.
  • the form must be sterile and must be fluid to the extent that easy syringability exists. It must be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms, such as bacteria and fungi.
  • Carriers used also can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), suitable mixtures thereof, and vegetable oils.
  • the proper fluidity can be maintained, for example, by the use of a coating, such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants.
  • the prevention of the action of microorganisms can be brought about by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, sorbic acid, thimerosal, and the like.
  • isotonic agents for example, sugars or sodium chloride.
  • Prolonged absorption of the injectable compositions can be brought about by the use in the compositions of agents delaying absorption, for example, aluminum monostearate and gelatin.
  • Sterile injectable solutions are prepared by incorporating the active compounds in the required amount in the appropriate solvent with various of the other ingredients enumerated above, as required, followed by filtered sterilization.
  • dispersions are prepared by incorporating the various sterilized active ingredients into a sterile vehicle which contains the basic dispersion medium and the required other ingredients from those enumerated above.
  • the preferred methods of preparation are vacuum-drying and freeze-drying techniques which yield a powder of the active ingredient plus any additional desired ingredient from a previously sterile-filtered solution thereof.
  • compositions may be formulated in suppositories and, in some cases, aerosol and intranasal compositions.
  • vehicle composition will include traditional binders and carriers such as polyalkylene glycols or triglycerides.
  • suppositories may be formed from mixtures containing the active ingredient in the range of about 0.5% to about 10% (w/w), preferably about 1% to about 2%.
  • Ectophosphatase inhibitors will commonly comprise from less than 1% to about 10% w/v of a composition with an active ingredient, including about 1%, 3%, 5%, &% and about 10%. Greater or lesser amounts of the ectophosphatase inhibitors may similarly be used. Desired concentrations may readily be determined by serial preparation and assay of compositions comprising varying amounts of the selected ectophosphatase inhibitor compound. For example, in the case of herbicidal compositions, a series of test compositions comprising from about 0.1% to about 25% w/v of an ectophosphatase inhibitor together with a test herbicide may be analyzed by leaf painting and comparison of the results. Safety, efficacy, cost and other concerns may each be taken into account in selecting the desired concentrations. Alternatively, pharmaceutical compositions may be analyzed using in vitro or in vivo models.
  • compositions may be prepared in the form of solutions, suspensions, tablets, pills, capsules, sustained release formulations, or powders. These compositions can be administered, for example, by swallowing or inhaling.
  • a pharmaceutical composition is to be inhaled, the composition will preferably comprise an aerosol.
  • Exemplary procedures for the preparation of aqueous aerosols may be found in U.S. Pat. No. 5,049,388, the disclosure of which is specifically incorporated herein by reference in its entirety.
  • Preparation of dry aerosol preparations are described in, for example, U.S. Pat. No. 5,607,915, the disclosure of which is specifically incorporated herein by reference in its entirety.
  • compositions can similarly include any other suitable carriers, excipients or diluents.
  • Other topical formulations can be administered to treat certain disease indications.
  • intranasal formulations may be prepared which include vehicles that neither cause irritation to the nasal mucosa nor significantly disturb ciliary function.
  • Diluents such as water, aqueous saline or other known substances can be employed with the subject invention.
  • the nasal formulations also may contain preservatives such as, but not limited to, chlorobutanol and benzalkonium chloride.
  • a surfactant may be present to enhance absorption of the subject compounds by the nasal mucosa.
  • solutions may be administered in a manner compatible with the dosage formulation and in such amount as is therapeutically effective.
  • the formulation of choice can be accomplished using a variety of excipients including, for example, pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, sodium saccharin cellulose, magnesium carbonate, and the like.
  • pharmaceutical compositions will contain from less than 1% to about 95% of the active ingredient, preferably about 10% to about 50%.
  • between about 10 mg/kg patient body weight per day and about 25 mg/kg patient body weight per day will be administered to a patient, including a human patient.
  • the frequency of administration will be determined by the care given based on patient responsiveness.
  • Other effective dosages can be readily determined by one of ordinary skill in the art through routine trials establishing dose response curves.
  • suitable pharmaceutical compositions in accordance with the invention will generally include an amount of active ingredient admixed with an acceptable pharmaceutical diluent or excipient, such as a sterile aqueous solution, to give a range of final concentrations, depending on the intended use.
  • an acceptable pharmaceutical diluent or excipient such as a sterile aqueous solution
  • the techniques of preparation are generally well known in the art as exemplified by Remington's Pharmaceutical Sciences, 16th Ed. Mack Publishing Company, 1980, which reference is specifically incorporated herein by reference in its entirety. It should be appreciated that endotoxin contamination should be kept minimally at a safe level, for example, less that 0.5 ng/mg protein.
  • preparations should meet sterility, pyrogenicity, general safety and purity standards as required by FDA Office of Biological Standards.
  • the therapeutically effective doses are readily determinable using an animal model. For example, experimental animals exhibiting a target infection or other ailment are frequently used to optimize appropriate therapeutic doses prior to translating to a clinical environment. Such models are known to be very reliable in predicting effective therapies.
  • delayed release formulations could be used that provided limited but constant amounts of the therapeutic agent over and extended period of time.
  • continuous perfusion of the region of interest may be preferred. This could be accomplished by catheterization, post-operatively in some cases, followed by continuous administration of the therapeutic agent.
  • the time period for perfusion would be selected by the clinician for the particular patient and situation, but times could range from about 1-2 hours, to 2-6 hours, to about 6-10 hours, to about 10-24 hours, to about 1-2 days, to about 1-2 weeks or longer.
  • the dose of the therapeutic composition via continuous perfusion will be equivalent to that given by single or multiple injections, adjusted for the period of time over which the injections are administered. It is believed that higher doses may be achieved via perfusion, however.
  • kits comprising the compositions described herein are also provided by the invention.
  • Such kits will generally contain, in suitable container means, a pharmaceutically or agriculturally acceptable formulation of the active ingredient.
  • the kits also may contain other pharmaceutically acceptable formulations, such as an antiinfective agent, including an insecticide, antifungal or antibacterial, as well as a herbicide.
  • kits may have a single container means that contains the active ingredient, with or without any additional components, or they may have distinct container means for each desired agent.
  • the liquid solution is an aqueous solution, with a sterile aqueous solution being particularly preferred.
  • the components of the kit may be provided as dried powder(s).
  • reagents or components are provided as a dry powder, the powder can be reconstituted by the addition of a suitable solvent. It is envisioned that the solvent also may be provided in another container means.
  • the container means of the kit will generally include at least one vial, test tube, flask, bottle, syringe or other container means, into which the active compound, and any other desired agent, may be placed and, preferably, suitably aliquoted. Where additional components are included, the kit will also generally contain a second vial or other container into which these are placed, enabling the administration of separated designed doses. The kits also may comprise a second/third container means for containing a sterile, pharmaceutically acceptable buffer or other diluent.
  • kits also may contain a means by which to administer the compositions to an animal or patient, e.g., one or more needles or syringes, or even an eye dropper, pipette, or other such like apparatus, from which the formulation may be injected into the animal or applied to a afflicted area of the body.
  • kits of the present invention will also typically include a means for containing the vials, or such like, and other component, in close confinement for commercial sale, such as, e.g., injection or blow-molded plastic containers into which the desired vials and other apparatus are placed and retained.
  • the invention also provides compositions formulated for agricultural use.
  • formulations include herbicidal, fungicidal and plant growth regulator compositions.
  • Specific formulations for plant application are known to those of skill in the art and are described, for example, in U.S. Pat. No. 6,242,382, the disclosure of which is specifically incorporated herein by reference in its entirety.
  • ingredients that may be included in a composition of the invention formulated for application to plants include surfactants, solid or liquid carriers, solvents and binders.
  • suitable surfactants that may be used for application to plants include the alkali metal, alkaline earth metal or ammonium salts of aromatic sulfonic acids, e.g., ligno-, phenol-, naphthalene- and dibutylnaphthalenesulfonic acid, and of fatty acids of arylsulfonates, of alkyl ethers, of lauryl ethers, of fatty alcohol sulfates and of fatty alcohol glycol ether sulfates, condensates of sulfonated naphthalene and its derivatives with formaldehyde, condensates of naphthalene or of the naphthalenesulfonic acids with phenol and formaldehyde, condensates of phenol or phenolsulfonic acid with formaldehy
  • compositions for application to plants may be solid or liquid. Where solid compositions are used, it may be desired to include one or more carrier materials with the active compound.
  • carriers include mineral earths such as silicas, silica gels, silicates, talc, kaolin, attaclay, limestone, chalk, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, thiourea and urea, products of vegetable origin such as cereal meals, tree bark meal, wood meal and nutshell meal, cellulose powders, attapulgites, montmorillonites, mica, vermiculites, synthetic silicas and synthetic calcium silicates, or mixtures of these.
  • water-soluble compounds or salts may be included, such as sodium sulfate, potassium sulfate, sodium chloride, potassium chloride, sodium acetate, ammonium hydrogen sulfate, ammonium chloride, ammonium acetate, ammonium formate, ammonium oxalate, ammonium carbonate, ammonium hydrogen carbonate, ammonium thiosulfate, ammonium hydrogen diphosphate, ammonium dihydrogen monophosphate, ammonium sodium hydrogen phosphate, ammonium thiocyanate, ammonium sulfamate or ammonium carbamate.
  • compositions of the invention include binders such as polyvinylpyrrolidone, polyvinyl alcohol, partially hydrolyzed polyvinyl acetate, carboxymethylcellulose, starch, vinylpyrrolidone/vinyl acetate copolymers and polyvinyl acetate, or mixtures of these; lubricants such as magnesium stearate, sodium stearate, talc or polyethylene glycol, or mixtures of these; antifoams such as silicone emulsions, long-chain alcohols, phosphoric esters, acetylene diols, fatty acids or organofluorine compounds, and complexing agents such as: salts of ethylenediaminetetraacetic acid (EDTA), salts of trinitrilotriacetic acid or salts of polyphosphoric acids, or mixtures of these.
  • binders such as polyvinylpyrrolidone, polyvinyl alcohol, partially hydrolyzed polyvinyl acetate, carboxymethylcellulose,
  • compositions are provided with herbicidal activity which comprise one or more ectophosphatase inhibitor(s) and a herbicide selected from the group consisting of pendimethalin, dicamba, 2,4-D, glufosinate, bentazon, trifluralin, oryzalin, S-metolachlor, nicosulfuron, MSMA, EpicTM and BalanceTM.
  • the ectophosphatase inhibitor is selected from the group of the compounds of formulae I-XX.
  • compositions with fungicidal activity comprise one or more ectophosphatase inhibitor(s) in combination with metalaxyl, tebuconazole, propiconazole, chlorothalonil and/or fluconazole.
  • Non-limiting examples of combinations of cytotoxic agents and ectophosphatase inhibitors for use in accordance with the invention include: fluconazole with compound(s) of formula II, IX, XIV, XVI, XV, X and/or XII; formula I and/or II with pendimethalin, dicamba, 2,4-D, bentazon, trifluralin, flufenacet/isoxaflutole or isoxaflutole; glufosinate with formula II; oryzalin with formula I; nicosulflron with formula II; MSMA with formula XVIII; S-metolachlor with formula VI and/or X; metribuzin with formula I, II and/or X; diuron with formula VI; metalaxyl with formula X; chlorothalonil with formula II, X, IX, XI, XVI; propiconazole with formula I, X, XIV and/or X
  • compositions comprising combinations of ectophosphatase inhibitors and cytotoxic agents or other active ingredients, including a herbicide, insecticide, antibiotic, fungicide, plant growth regulator and/or hormone.
  • Such combinations may provide enhanced activity of the active ingredient relative to the use of a single ectophosphatase inhibitor.
  • Non-limiting examples of such combinations of ectophosphatase inhibitors include combinations of two, three, four or more ectophosphatase inhibitors selected from formulas I, II, VI, X, XV, XIV, XVI, XVI, XV, and XVIII.
  • compositions comprising an ectophosphatase inhibitor and an active ingredient set forth in Table 1.
  • Table 1 Cytotoxic agents and other active ingredients
  • U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Bis(2-ethylhexyl) phthalate 117-81-7 3E+05 NA 11 N/A Alkyl Phthalate Butyl benzyl phthalate 85-68-7 NA 141 3080 N/A Alkyl Phthalate Chlorthal-dimethyl 1861-32-1 78701 179
  • the effectiveness of herbicides is augmented by methods and compositions for the contemporaneous administration of one or more ectophosphatase inhibitors in combination with herbicides.
  • Such applications may, in addition to increasing the effectiveness of herbicides, allow the use of reduced concentrations of herbicides, thereby providing cost and environmental benefits.
  • compositions comprising one or more ectophosphatase inhibitor(s) in combination with one or more herbicide(s) listed in Table 1.
  • the ectophosphatase inhibitor may or may not be a compound selected from formula I-XX.
  • the herbicidal compositions or other compositions formulated for agricultural use, including compositions comprising insecticides and growth regulators, may be used with potentially any plant.
  • Non-limiting examples of plant genera that may be treated in accordance with the invention include: Abutilon, Amaranthus, Artemisia, Asclepias, Avena, Axonopus, Borreria, Brachiaria, Brassica, Bromus, Chenopodium, Cirsium, Commelina, Convolvulus, Cynodon, Cyperus, Digitaria, Echinochloa, Eleusine, Elymus, Equisetum, Erodium, Helianthus, Imperata, Ipomoea, Kochia, Lolium, Malva, Oryza, Ottochloa, Panicum, Paspalum, Phalaris, Phragmites, Polygonum, Portulaca, Pteridium, Pueraria, Rubus, Salsola, Setaria, Sida, Sinapis, Sorghum, Triticum, Typha, Ulex, Xanthium , and Zea .
  • Non-limiting common types of plants that may be controlled in accordance with the invention include varieties of grasses, broad leafs, succulents, trees and shrubs, barley, black nightshade, broadleaf signal grass, burcumber, chickweed, common ragweed, crabgrass, field pennycress, rough fleabane, foxtail, giant ragweed, goose grass, groundcherry, hemp sesbarria, henbit, jungle rice, kochia, lambs quarters, morning-glory spp., mustard, fall and Texas panicum, palma amaranth, prickly sida (teaweed), red rice, rye, seedling shattercone, shepherd's purse, sicklepod, sprangletop, sunflower, velvet leaf, volunteer corn, common and tall waterhemp, wheat, wild proso millet, witchgrass, wolly cupgrass; and common perennial weeds including Canada thistle, common milkweed, field bindweed, hemp dogbane, red vine, rhizone johnson grass
  • Non-limiting examples of species that may be controlled include velvetleaf ( Abutilon theophrasti ), pigweed ( Amaranthus spp.), buttonweed ( Borreria spp.), oilseed rape, canola, indian mustard, etc. ( Brassica spp.), commelina ( Commelina spp.), filaree ( Erodium spp.), sunflower ( Helianthus spp.), morningglory ( Ipomoea spp.), kochia ( Kochia scoparia ), mallow ( Malva spp.), wild buckwheat, smartweed, etc.
  • Crop and other cultivated species may also be contacted with a composition of the invention.
  • cultivated plants include, but are not limited to, species from the genera Fragaria, Lotus, Medicago, Onobrychis, Trifolium, Trigonella, Vigna, Citrus, Linum, Geranium, Manihot, Daucus, Arabidopsis, Brassica, Raphanus, Sinapis, Atropa, Capsicum, Datura, Hyoscyamus, Lycopersicon, Nicotiana, Helianthus, Lactuca, Bromus, Asparagus, Antirrhinum, Hemerocallis, Nemesia, Pelargonium, Panicum, Pennisetum, Ranunculus, Senecio, Salpiglossis, Cucumis, Bromelia, Glycine, Lolium, Zea, Triticum, Sorghum, Ipomoea, Passifora, Cyclamen, Malus, Prumus, Rosa, Rubus, Populus
  • a common class of plants exploited in agriculture are vegetable crops, including artichokes, kohlrabi, arugula, leeks, asparagus, lettuce (e.g., head, leaf, romaine), bok choy, malanga, broccoli, melons (e.g., muskmelon, watermelon, crenshaw, honeydew, cantaloupe), brussels sprouts, cabbage, cardoni, carrots, napa, cauliflower, okra, onions, celery, parsley, chick peas, parsnips, chicory, Chinese cabbage, peppers, collards, potatoes, cucumber plants (marrows, cucumbers), pumpkins, cucurbits, radishes, dry bulb onions, rutabaga, eggplant, salsify, escarole, shallots, endive, garlic, spinach, green onions, squash, greens, beet (sugar beet and fodder beet), sweet potatoes, swiss-chard, horseradish, tomatoes
  • fruit and vine crops such as apples, apricots, cherries, nectarines, peaches, pears, plums, prunes, quince almonds, chestnuts, filberts, pecans, pistachios, walnuts, citrus, blueberries, boysenberries, cranberries, currants, loganberries, raspberries, strawberries, blackberries, grapes, avocados, bananas, kiwi, persimmons, pomegranate, pineapple, tropical fruits, pomes, melon, mango, papaya, and lychee.
  • fruit and vine crops such as apples, apricots, cherries, nectarines, peaches, pears, plums, prunes, quince almonds, chestnuts, filberts, pecans, pistachios, walnuts, citrus, blueberries, boysenberries, cranberries, currants, loganberries, raspberries, strawberries, blackberries, grapes, avocados, bananas, kiwi, persimmons, pom
  • ornamental plants Another economically important group of plants are ornamental plants.
  • Examples of commonly grown ornamental plants include alstroemeria (e.g., Alstoemeria brasiliensis ), aster, azalea (e.g., Rhododendron sp.), begonias (e.g., Begonia sp.), bellflower, bouganvillea, cactus (e.g., Cactaceae schlumbergera truncata ), camellia, carnation (e.g., Dianthus caryophyllus ), chrysanthemums (e.g., Chrysanthemum sp.), clematis (e.g., Clematis sp.), cockscomb, columbine, cyclamen (e.g., Cyclamen sp.), daffodils (e.g., Narcissus sp.), false cypress, freesia (e.g.,
  • Antibiotics are any chemical of natural or synthetic origin that kill or inhibit the growth of other types cells. Many clinically-useful antibiotics are produced by microorganisms. Antibiotics are typically low molecular-weight (non-protein) molecules produced as secondary metabolites, mainly by microorganisms that live in the soil. Most of these microorganisms form some type of a spore or other dormant cell, and there is thought to be some relationship (besides temporal) between antibiotic production and the processes of sporulation.
  • Penicillium and Cephalosporium are the main source of the beta-lactam antibiotics (penicillin and its relatives).
  • the Actinomycetes notably Streptomyces species, produce a variety of types of antibiotics including the aminoglycosides (e.g. streptomycin), macrolides (e.g. erythromycin), and the tetracyclines.
  • Endospore-forming Bacillus species produce polypeptide antibiotics such as polymyxin and bacitracin.
  • Table 1 is a summary of the classes of antibiotics and their properties including their biological sources.
  • compositions comprising an ectophosphatase inhibitor and an antibiotic of a class selected from the group consisting of: beta-lactams (penicillins and cephalosporins); semisynthetic penicillin; clavulanic Acid; monobactams; carboxypenems; aminoglycosides; glycopeptides; lincomycins; macrolides; polypeptides; chloramphenicol; polyenes; rifamycins; tetracyclines; and semisynthetic tetracycline.
  • an ectophosphatase inhibitor may be used in conjuntion with these classes of antibiotics.
  • the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulas I-XX.
  • Antibiotics may have a cidal (killing) effect or a static (inhibitory) effect on a range of microbes. The range of bacteria or other microorganisms that are affected by a certain antibiotic are is expressed as its spectrum of action.
  • Antibiotics effective against prokaryotes which kill or inhibit a wide range of Gram-positive and Gram-negative bacteria are said to be broad spectrum. If effective mainly against Gram-positive or Gram-negative bacteria, they are narrow spectrum. If effective against a single organism or disease, they are referred to as limited spectrum.
  • certain adverse effects of antibiotics may be minimized by use of en ectophosphatase inhibitor in combination with the antibiotic, thereby allowing use of lower doses of antibiotics.
  • ectophosphatase inhibitors are used in conjunction with cell wall synthesis inhibitors.
  • Cell wall synthesis inhibitors generally inhibit some step in the synthesis of bacterial peptidoglycan. Generally they exert their selective toxicity against eubacteria because human cells lack cell walls.
  • Beta lactam antibiotics contain a 4-membered beta lactam ring. They are the products of two groups of fungi, Penicillium and Cephalosporium molds, and are correspondingly represented by the penicillins and cephalosporins. The beta lactam antibiotics inhibit the last step in peptidoglycan synthesis, the final cross-linking between peptide side chains, mediated by bacterial carboxypeptidase and transpeptidase enzymes. Beta lactam antibiotics are normally bactericidal and require that cells be actively growing in order to exert their toxicity.
  • Natural penicillins such as Penicillin G or Penicillin V, are produced by fermentation of Penicillium chrysogenum . They are effective against streptococcus, gonococcus and staphylococcus, except where resistance has developed. They are considered narrow spectrum since they are not effective against Gram-negative rods.
  • Penicillins date to 1959. Mold produces a main part of the penicillin molecule (6-aminopenicillanic acid) which can be modified chemically by the addition of side chains. Many of these compounds have been developed to have distinct benefits or advantages over penicillin G, such as increased spectrum of activity (effectiveness against Gram-negative rods), resistance to penicillinase, effectiveness when administered orally, etc. Amoxycillin and Ampicillin have broadened spectra against Gram-negatives and are effective orally; Methicillin is penicillinase-resistant.
  • Clavulanic acid is a chemical sometimes added to a semisynthetic penicillin preparation.
  • amoxycillin plus clavulanate is clavamox or augmentin.
  • the clavulanate is not an antimicrobial agent. It inhibits beta lactamase enzymes and has given extended life to penicillinase-sensitive beta lactams.
  • Cephalolsporins are beta lactam antibiotics with a similar mode of action to penicillins that are produced by species of Cephalosporium . The have a low toxicity and a somewhat broader spectrum than natural penicillins. They are often used as penicillin substitutes, against Gram-negative bacteria, and in surgical prophylaxis. They are subject to degradation by some bacterial beta-lactamases, but they tend to be resistant to beta-lactamases from S. aureus.
  • Bacitracin is a polypeptide antibiotic produced by Bacillus species. It prevents cell wall growth by inhibiting the release of the muropeptide subunits of peptidoglycan from the lipid carrier molecule that carries the subunit to the outside of the membrane Teichoic acid synthesis, which requires the same carrier, is also inhibited. Bacitracin has a high toxicity which precludes its systemic use. It is present in many topical antibiotic preparations, and since it is not absorbed by the gut, it is given to “sterilize” the bowel prior to surgery.
  • Cell membrane inhibitors disorganize the structure or inhibit the function of bacterial membranes.
  • the integrity of the cytoplasmic and outer membranes is vital to bacteria, and compounds that disorganize the membranes rapidly kill the cells.
  • This action is rarely specific enough to permit these compounds to be used systemically.
  • the only antibacterial antibiotic of clinical importance that acts by this mechanism is Polymyxin, produced by Bacillus polymyxis .
  • Polymyxin is effective mainly against Gram-negative bacteria and is usually limited to topical usage. Polymyxins bind to membrane phospholipids and thereby interfere with membrane function.
  • Polymyxin is occasionally given for urinary tract infections caused by Pseudomonas that are gentamicin, carbenicillin and tobramycin resistant. The balance between effectiveness and damage to the kidney and other organs is dangerously close, and the drug should only be given under close supervision in the hospital.
  • ectophosphatase inhibitors may also be contemporaneously administered and formulated in compositions with antibiotics that are protein synthesis inhibitors.
  • antibiotics that are protein synthesis inhibitors.
  • Many therapeutically useful antibiotics inhibit some step in the complex process of translation. The attack is at one of the events occurring on the ribosome, rather than the stage of amino acid activation or attachment to a particular tRNA. Most have an affinity or specificity for 70S (as opposed to 80S) ribosomes, and they achieve their selective toxicity in this manner.
  • the most important antibiotics with this mode of action are the tetracyclines, chloramphenicol, the macrolides (e.g. erythromycin) and the aminoglycosides (e.g. streptomycin).
  • the aminoglycosides are products of Streptomyces species and are represented by streptomycin, kanamycin, tobramycin and gentamicin. These antibiotics exert their activity by binding to bacterial ribosomes and preventing the initiation of protein synthesis. Aminoglycosides have been used against a wide variety of bacterial infections caused by Gram-positive and Gram-negative bacteria. Streptomycin has been used extensively as a primary drug in the treatment of tuberculosis. Gentamicin is active against many strains of Gram-positive and Gram-negative bacteria, including some strains of Pseudomonas aeruginosa .
  • Kanamycin (a complex of three antibiotics, A, B and C) is active at low concentrations against many Gram-positive bacteria, including penicillin-resistant staphylococci. Gentamicin and Tobramycin are mainstays for treatment of Pseudomonas infections. An unfortunate side effect of aminoglycosides has tended to restrict their usage: prolonged use is known to impair kidney function and cause damage to the auditory nerves leading to deafness.
  • the tetracyclines consist of eight related antibiotics which are all natural products of Streptomyces , although some can now be produced semisynthetically. Tetracycline, chlortetracycline and doxycycline are the best known.
  • the tetracyclines are broad-spectrum antibiotics with a wide range of activity against both Gram-positive and Gram-negative bacteria.
  • the tetracyclines act by blocking the binding of aminoacyl tRNA to the A site on the ribosome. Tetracyclines inhibit protein synthesis on isolated 70S or 80S (eukaryotic) ribosomes, and in both cases, their effect is on the small ribosomal subunit.
  • tetracyclines have a remarkably low toxicity and minimal side effects when taken by animals.
  • the combination of their broad spectrum and low toxicity has led to their overuse and misuse by the medical community and the wide-spread development of resistance has reduced their effectiveness. Nonetheless, tetracyclines still have some important uses, such as in the treatment of Lyme disease.
  • Chloramphenicol has a broad spectrum of activity but it exerts a bacteriostatic effect. It is effective against intracellular parasites such as the rickettsiae. Unfortunately, aplastic anemia, which is dose related develops in a small proportion (1/50,000) of patients. Chloramphenicol was originally discovered and purified from the fermentation of a Streptomyces , but currently it is produced entirely by chemical synthesis. Chloramphenicol inhibits the bacterial enzyme peptidyl transferase thereby preventing the growth of the polypeptide chain during protein synthesis.
  • Chloramphenicol is entirely selective for 70S ribosomes and does not affect 80S ribosomes. Its unfortunate toxicity towards the small proportion of patients who receive it is in no way related to its effect on bacterial protein synthesis. However, since mitochondria probably originated from prokaryotic cells and have 70S ribosomes, they are subject to inhibition by some of the protein synthesis inhibitors including chloroamphenicol. This likely explains the toxicity of chloramphenicol. The eukaryotic cells most likely to be inhibited by chloramphenicol are those undergoing rapid multiplication, thereby rapidly synthesizing mitochondria. Such cells include the blood forming cells of the bone marrow, the inhibition of which could present as aplastic anemia. Chloramphenicol was once a highly prescribed antibiotic and a number of deaths from anemia occurred before its use was curtailed. Now it is seldom used in human medicine except in life-threatening situations (e.g. typhoid fever).
  • the Macrolides are a family of antibiotics whose structures contain large lactone rings linked through glycoside bonds with amino sugars. The most important members of the group are erythromycin and oleandomycin. Erythromycin is active against most Gram-positive bacteria, Neisseria, Legionella and Haemophilus , but not against the Enterobacteriaceae. Macrolides inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit. Binding inhibits elongation of the protein by peptidyl transferase or prevents translocation of the ribosome or both. Macrolides are bacteriostatic for most bacteria but are cidal for a few Gram-positive bacteria.
  • ectophosphatase inhibitors may be contemporaneously administered and formulated in compositions with antibiotics that affect nucleic acids, including chemotherapeutic agents that affect the synthesis of DNA or RNA, or can bind to DNA or RNA so that their messages cannot be read. In either case, this can block the growth of cells.
  • antibiotics that affect nucleic acids
  • chemotherapeutic agents that affect the synthesis of DNA or RNA
  • bind to DNA or RNA so that their messages cannot be read. In either case, this can block the growth of cells.
  • the majority of these drugs are unselective, however, and affect animal cells and bacterial cells alike and therefore have no therapeutic application.
  • Two nucleic acid synthesis inhibitors which have selective activity against prokaryotes and some medical utility are nalidixic acid and rifamycins.
  • Nalidixic acid is a synthetic chemotherapeutic agent which has activity mainly against Gram-negative bacteria.
  • Nalidixic acid belongs to a group of compounds called quinolones.
  • Nalidixic acid is a bactericidal agent that binds to the DNA gyrase enzyme (topoisomerase) which is essential for DNA replication and allows supercoils to be relaxed and reformed. Binding of the drug inhibits DNA gyrase activity.
  • nalidixic acid is in treatment of lower urinary tract infections (UTI).
  • UTI urinary tract infections
  • the compound is unusual in that it is effective against several types of Gram-negative bacteria such as E. coli, Enterobacter aerogentes, K. pneumoniae and Proteus species which are common causes of UTI. It is not usually effective against Pseudomonas aeruginosa , and Gram-positive bacteria are resistant.
  • the rifamycins are also the products of Streptomyces .
  • Rifampicin is a semisynthetic derivative of rifamycin that is active against Gram-positive bacteria (including Mycobacterium tuberculosis ) and some Gram-negative bacteria.
  • Rifampicin acts quite specifically on eubacterial RNA polymerase and is inactive towards RNA polymerase from animal cells or towards DNA polymerase.
  • the antibiotic binds to the beta subunit of the polymerase and apparently blocks the entry of the first nucleotide which is necessary to activate the polymerase, thereby blocking mRNA synthesis. It has been found to have greater bactericidal effect against M.
  • tuberculosis than other anti-tuberculosis drugs, and it has largely replaced isoniazid as one of the front-line drugs used to treat the disease, especially when isoniazid resistance is indicated. It is effective orally and penetrates well into the cerebrospinal fluid and is therefore useful for treatment of tuberculosis meningitis and meningitis caused by Neisseria meningitidis.
  • ectophosphatase inhibitors may also be administered with competitive inhibitors, including mostly all synthetic chemotherapeutic agents. Most are “growth factor analogs” which are structurally similar to a bacterial growth factor but which do not fulfill its metabolic function in the cell. Some are bacteriostatic and some are bactericidal.
  • Sulfonamides were originally introduced as chemotherapeutic agents, one of which, prontosil, had the effect of curing mice with infections caused by beta-hemolytic streptococci. Chemical modifications of the compound sulfanilamide gave compounds with even higher and broader antibacterial activity. The resulting sulfonamides have broadly similar antibacterial activity, but differ widely in their pharmacological actions. Bacteria which are almost always sensitive to the sulfonamides include Streptococcus pneumoniae , beta-hemolytic streptococci and E. coli . The sulfonamides have been extremely useful in the treatment of uncomplicated UTI caused by E. coli , and in the treatment of meningococcal meningitis, because they cross the blood-brain barrier.
  • the sulfonamides are inhibitors of the bacterial enzymes required for the synthesis of tetrahydofolic acid (THF), the vitamin form of folic acid essential for 1-carbon transfer reactions.
  • Sulfonamides are structurally similar to para aminobenzoic acid (PABA), the substrate for the first enzyme in the THF pathway, and they competitively inhibit that step.
  • Trimethoprim is structurally similar to dihydrofolate (DHF) and competitively inhibits the second step in THF synthesis mediated by the DHF reductase.
  • Animal cells do not synthesize their own folic acid but obtain it in a preformed fashion as a vitamin. Since animals do not make folic acid, they are not affected by these drugs, which achieve their selective toxicity for bacteria on this basis.
  • tuberculosis Three additional synthetic chemotherapeutic agents have been used in the treatment of tuberculosis: isoniazid (INH), paraaminosalicylic acid (PAS), and ethambutol.
  • IH isoniazid
  • PAS paraaminosalicylic acid
  • ethambutol The usual strategy in the treatment of tuberculosis has been to administer a single antibiotic (historically streptomycin, but now, most commonly, rifampicin is given) in conjunction with INH and ethambutol. Since the tubercle bacillus rapidly develops resistance to the antibiotic, ethambutol and INH are given to prevent outgrowth of a resistant strain. It must also be pointed out that the tubercle bacillus rapidly develops resistance to ethambutol and INH if either drug is used alone.
  • Ethambutol inhibits incorporation of mycolic acids into the mycobacterial cell wall.
  • Isoniazid has been reported to inhibit mycolic acid synthesis in mycobacteria and since it is an analog of pyridoxine (Vitamin B6) it may inhibit pyridoxine catalyzed reactions as well.
  • Isoniazid is activated by a mycobacterial peroxidase enzyme and destroys several targets in the cell.
  • PAS is an anti-folate. PAS was once a primary anti-tuberculosis drug, but now it is a secondary agent, having been largely replaced by ethambutol.
  • the present invention also relates to methods for inhibiting or ameliorating infection in animals and humans caused by microorganisms.
  • treatment of bacterial and fungal infections may be augmented or effected using inhibitory mechanisms against an ectophosphatase to modify the ATP gradient across biological membranes.
  • the invention is useful in the inhibition or amelioration of a wide range of infections including, but not limited to, gram negative bacterial infection including gram-negative sepsis, gram-negative endotoxin-related hypotension and shock, rabies, cholera, tetanus, lymes disease, tuberculosis, Candida albicans, Chlamydia , etc.
  • the inhibition or amelioration of the infections may involve the administration of an anti-microbial agent (such as an antibiotic or an antifungal agent) with the concurrent administration of the aforementioned compositions.
  • an anti-microbial agent such as an antibiotic or an antifungal agent
  • inhibitors of ectophosphatases or ABC transporters may be administered via a physiologically acceptable carrier as described above.
  • the inhibitor of ectophosphatase is selected from the compounds represented by formulas I-XX.
  • Certain aspects of the current invention thus concern the inhibition of cell growth by contacting a cell with an inhibitor of an ectophosphatase with contemporaneous administration of other agents capable of inhibiting cell growth or killing the cell.
  • therapeutic benefit may be obtained for the treatment of bacterial infections.
  • types of bacteria that could be inhibited and bacterial infections that could potentially be treated or prevented with the invention include, but are not limited to, the 83 or more distinct serotypes of pneumococci, streptococci such as S. pyogenes, S. agalactiae, S. equi, S. canis, S. bovis, S. equinus, S. anginosus, S. sanguis, S. salivarius, S.
  • the invention may also find use, for example, against gram negative bacteria such as Klebsiella pneumoniae, Escherichia coli, Proteus, Serratia species, Acinetobacter, Yersinia pestis, Francisella tularensis, Enterobacter species, Bacteriodes and Legionella species and the like.
  • chemotherapeutic agents are suitable for use with the invention and are known to those of skill in the art.
  • therapeutic benefit may be obtained by contemporaneous administration of one or more ectophosphatase inhibitor and one or more such chemotherapeutic agent(s).
  • Co-administration of chemotherapeutics with ectophosphatase inhibitors in accordance with the invention may be used to increase therapeutic effectiveness of a chemotherapeutic and may allow use of lowered doses. Such techniques may further allow treatment of chemotherapy-resistant tumor cells.
  • chemotherapeutic agents will be generally around those already employed in clinical therapies wherein the chemotherapeutics are administered alone or in combination with other chemotherapeutics.
  • agents such as cisplatin, and other DNA alkylating agents may be used with an ectophosphatase inhibitor.
  • Cisplatin has been widely used to treat cancer, with efficacious doses used in clinical applications of 20 mg/m 2 for 5 days every three weeks for a total of three courses. Cisplatin is not absorbed orally and must therefore be delivered via injection intravenously, subcutaneously, intratumorally or intraperitoneally.
  • chemotherapeutic compounds include adriamycin, also known as doxorubicin, etoposide, verapamil, podophyllotoxin, and the like. Widely used in a clinical setting for the treatment of neoplasms, these compounds are administered through bolus injections intravenously at doses ranging from 25-75 mg/m 2 at 21 day intervals for adriamycin, to 35-50 mg/m 2 for etoposide intravenously or double the intravenous dose orally.
  • Agents that disrupt the synthesis and fidelity of polynucleotide precursors also may be used with ectophosphatase inhibitors. Particularly useful are agents that have undergone extensive testing and are readily available. As such, agents such as 5-fluorouracil (5-FU) are preferentially used by neoplastic tissue, making this agent particularly useful for targeting to neoplastic cells. Although quite toxic, 5-FU is applicable in a wide range of carriers, including topical, with intravenous administration in doses ranging from 3 to 15 mg/kg/day being commonly used.
  • 5-FU 5-fluorouracil
  • compositions comprising these agents and one or more ectophosphatase inhibitor(s) form one part of the invention, as do methods for the administration thereof.
  • agents listed below are exemplary and by no means limiting.
  • the skilled artisan is directed to “Remington's Pharmaceutical Sciences” 15th Edition, chapter 33, in particular pages 624-652. Some variation in dosage will necessarily occur depending on the condition of the subject being treated. The person responsible for administration will, in any event, determine the appropriate dose for the individual subject.
  • preparations should meet sterility, pyrogenicity, general safety and purity standards as required by FDA Office of Biologics standards.
  • compositions comprising and ectophosphatase inhibitor and a chemotherapeutic agent set forth in Table 3, as well as methods comprising the use thereof TABLE 3 Chemotherapeutic Agents Useful In Neoplastic Disease NONPROPRIETARY TYPE OF NAMES CLASS AGENT (OTHER NAMES) DISEASE Mechlorethamine (HN 2 ) Hodgkin's disease, non-Hodgkin's lymphomas Nitrogen Cyclophosphamide Acute and chronic Mustards Ifosfamide lymphocytic leukemias, Hodgkin's disease, non-Hodgkin's lymphomas, multiple myeloma, neuroblastoma, breast, ovary, lung, Wilms' tumor, cervix, testis, soft-tissue sarcomas Melphalan (L-sarcolysin) Multiple myeloma, breast, ovary Chlorambucil Chronic lymphocytic leuk
  • compositions provided by the invention may be local or systemic, using a suitable physiological carrier.
  • Other compounds which aid in the uptake or stability of these agents, or which have beneficial activity, may also be included in the formulations of the invention.
  • Certain embodiments of the invention thus provide pharmaceutical composition comprising an ectophosphatase inhibitor.
  • the composition may further comprise, in certain embodiments, a cytotoxic agent, including a chemotherapeutic agent set forth herein.
  • a cytotoxic agent including a chemotherapeutic agent set forth herein.
  • therapeutic benefit may be obtained where a tumor cell is resistant to at least one chemotherapeutic agent. This may enhance the overall anti-tumor activity achieved by therapy, and/or may be used to prevent or combat multi-drug tumor resistance.
  • assays are provided for screening compositions comprising combinations of ectophosphatase inhibitors and a selected cytotoxic agent, for example, a herbicide, fungicide, antibiotic, insecticide or chemotherapeutic agent.
  • a selected cytotoxic agent for example, a herbicide, fungicide, antibiotic, insecticide or chemotherapeutic agent.
  • assay formats are known to those of skill in the art and may be used in this regard. These include assays of biological activities as well as assays of chemical properties. The results of these assays provide important inferences as to the properties of compounds as well as their potential applications in treating human or other mammalian patients for infection and hyperproliferative diseases as well as in various agricultural applications.
  • Assays deemed to be of particular utility in this regard include in vivo and in vitro screens of activity and immunoassays.
  • herbicidal compositions having improved herbicidal activity may be used to asses the relative efficacy of combinations of ectophosphatase inhibitors and herbicidal agents.
  • Numerous assays formats for analyzing herbicidal activity are known to those of skill in the art and may be used in this regard.
  • a straightforward means for testing activity comprises the serial application of test compositions to plants and/or plant parts, for example, by leaf painting. Plants are otherwise grown under comparable conditions, followed by serial applications of test and control compositions are applied. Control treatments may be used comprising herbicide compositions lacking ectophosphatase inhibitors, thereby identifying the presence of absence of activity as a syngerist. Herbicidal activity is then measured by analysis of the effect of the composition on plant viability.
  • test and control compositions are administered in rates and/or amounts of from about 90% to about 5% of the commercial application rate for a given herbicide.
  • herbicidal activity and effectiveness is measured. Through comparisons with applications of control compositions, the effectiveness of the compositions may be determined.
  • Tests may be carried out on whole plants as well as plant parts or cell.
  • plant cells in tissue culture may be screened for herbicidal activity.
  • the preparation of plant tissue-cultures is well known to those of skill in the art.
  • the present invention encompasses the use of various animal models.
  • a potential therapeutic agent for example, an antiinfective or chemotherapeutic administered in combination with an ectophosphatase inhibitor.
  • chemotherapeutics one can utilize cancer models in mice that will be highly predictive of cancers in humans and other mammals. These models may employ the orthotopic or systemic administration of tumor cells to mimic primary and/or metastatic cancers. Alternatively, one may induce cancers in animals by providing agents known to be responsible for certain events associated with malignant transformation and/or tumor progression.
  • numerous animal models are available for analysis of antinfectives, including insecticides, antibiotics and antifungal agents. In this manner, all that is commonly required is infection of the relevant animal with a target infective agent and analysis of therapeutic benefit relative to prior antiinfective compositions.
  • Treatment of animals with test compositions will involve the administration of the composition, in an appropriate form, to the animal.
  • Administration will be by any route the could be utilized for clinical or non-clinical purposes, including but not limited to oral, nasal, buccal, rectal, vaginal or topical.
  • administration may be by intratracheal instillation, bronchial instillation, intradermal, subcutaneous, intramuscular, intraperitoneal or intravenous injection.
  • systemic intravenous injection regional administration via blood or lymph supply and intratumoral injection.
  • Determining the effectiveness of a compound in vivo may involve a variety of different criteria. Such criteria include, but are not limited to, survival, reduction of tumor burden or mass, arrest or slowing of tumor progression, elimination of tumors, inhibition or prevention of metastasis, increased activity level, improvement in immune effector function and improved food intake.
  • criteria include, but are not limited to, survival, reduction of tumor burden or mass, arrest or slowing of tumor progression, elimination of tumors, inhibition or prevention of metastasis, increased activity level, improvement in immune effector function and improved food intake.
  • compositions should generally be tested in an in vivo setting prior to use in a human subject. Such pre-clinical testing in animals is routine in the art. To conduct such confirmatory tests, all that is required is an art-accepted animal model of the disease in question, such as an animal bearing a solid tumor or infective agent. Any animal may be used in such a context, such as, e.g., a mouse, rat, guinea pig, hamster, rabbit, dog, chimpanzee, or such like. Studies using small animals such as mice are widely accepted as being predictive of clinical efficacy in humans, and such animal models may thus find use in the context of the present invention as they are readily available and relatively inexpensive, at least in comparison to other experimental animals.
  • chemotherapeutic compositions will be those that generally result in at least about 10% of the cells within a tumor exhibiting cell death or apoptosis. Preferably, at least about 20%, about 30%, about 40%, or about 50%, of the cells at a particular tumor site will be killed. Most preferably, 100% of the cells at a tumor site will be killed.
  • the extent of cell death in a tumor is assessed relative to the maintenance of healthy tissues in all of the areas of the body. It will be preferable to use doses of chemotherapeutic compositions capable of inducing at least about 60%, about 70%, about 80%, about 85%, about 90%, about 95% up to and including 100% tumor necrosis, so long as the doses used do not result in significant side effects or other untoward reactions in the animal. All such determinations can be readily made and properly assessed by those of ordinary skill in the art. For example, attendants, scientists and physicians can utilize such data from experimental animals in the optimization of appropriate doses for human treatment. In subjects with advanced disease, a certain degree of side effects can be tolerated. However, patients in the early stages of disease can be treated with more moderate doses in order to obtain a significant therapeutic effect in the absence of side effects. The effects observed in such experimental animal studies should preferably be statistically significant over the control levels and should be reproducible from study to study.
  • compositions provided by the invention that result in tumor-specific necrosis towards the lower end of the effective ranges may nonetheless still be useful in connection with the present invention.
  • an initial dose that results in only about 10% necrosis will nonetheless be useful, particularly as it is often observed that this initial reduction “primes” the tumor to further destructive assault upon subsequent re-application of the therapy.
  • any induction, of thrombosis and necrosis is nonetheless useful in that it represents an advance over the state of the patients prior to treatments.
  • a dose which prevents or decreases the likelihood of either metastasis or de novo carcinogenesis would also be of therapeutic benefit to a patient receiving the treatment.
  • compositions of the invention can be straightforwardly analyzed in the combinations set forth herein. Analysis of the combined effects of such agents would be determined and assessed according to the guidelines set forth above.
  • screening of a composition provided by the invention is conducted in vitro to identify those compounds capable of synergizing therapeutic agents, including cytotoxic agents such as antibiotics, fungicides and chemotherapeutic agents, as well as other types of biologically-active agents.
  • cytotoxic agents such as antibiotics, fungicides and chemotherapeutic agents
  • other types of biologically-active agents include cytotoxicity, cytotoxicity, cytotoxicity, cytotoxicity, cytotoxicity is generally exhibited by necrosis or apoptosis. Necrosis is a relatively common pathway triggered by external signals. During this process, the integrity of the cellular membrane and cellular compartments is lost.
  • apoptosis or programmed cell death
  • apoptosis is a highly organized process of morphological events that is synchronized by the activation and deactivation of specific genes (Thompson et al., 1992; Wyllie, 1985).
  • the selective cytotoxic action against the infective agent including an insect, bacterial or fungal pathogen, is typically analyzed.
  • An efficacious means for in vitro assaying of cytoxicity comprises the systematic exposure of a panel of cells to selected compositions.
  • a panel of cells For example, in the case of cancer, many tumor cell lines are available for implementing assays, including human ovarian, leukemic, breast, prostate, melanoma and renal cancer cells.
  • In vitro determinations of the efficacy of a compound in killing tumor cells may be achieved, for example, by assays of the expression and induction of various genes involved in cell-cycle arrest (p21, p27; inhibitors of cyclin dependent kinases) and apoptosis (bcl-2, bcl-x L and bax).
  • p21, p27; inhibitors of cyclin dependent kinases p21, p27; inhibitors of cyclin dependent kinases
  • apoptosis bcl-2, bcl-x L and bax.
  • the membranes are first probed with the primary antibodies (e.g., antibodies to p21, p27, bax, bcl-2 and bcl-x 1 , etc.) and then detected with diluted horseradish peroxidase conjugated secondary antibodies, and the membrane exposed to ECL detection reagent followed by visualization on ECL-photographic film.
  • the primary antibodies e.g., antibodies to p21, p27, bax, bcl-2 and bcl-x 1 , etc.
  • the purpose of this study was to evaluate various ectophosphatase inhibitor compounds for any potentiating effect or resistance reversal with methicillin resistant Staphylococcus aureus (MRSA).
  • MRSA methicillin resistant Staphylococcus aureus
  • Two strains of Staphylococcus aureus were obtained from the American Type Culture Collection (ATCC). Those obtained were a previously characterized methicillin resistant strain (# 43300) and a previously characterized methicillin sensitive strain (# 29213) to serve as a control. Strains were received as lyophilized pellets and were rehydrated according to the ATCC Product Information Sheet using Trypticase Soy Broth.
  • Mueller-Hinton agar plates were prepared containing 1 of 6 inhibitor compounds investigated. The compounds were dissolved in DMSO at concentrations of 20 mg/ml. 25 ⁇ l of this stock solution was added to 25 mls of media just prior to cooling to solidification to produce plates containing 20 ⁇ g/ml of inhibitor compound. Control plates containing 25 ⁇ l DMSO only were also prepared in the same fashion.
  • Protocols for the studies were according to NCCLS guidelines (M2-A7, M100-S11) for antimicrobial susceptibility testing.
  • Methodology for the serum bactericidal test was according to (Tentative Guideline) NCCLS M21-T, 1992.
  • Methods for determining bactericidal activity of antimicrobial agents was according to (Tentative Guideline) NCCLS M26-T.1992.
  • the screening test for Oxacillin-resistant Staphylococci was according to NCCLS M7-A4. Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals was according to (Approved Standard) NCCLS M31-A. Performance standards for antimicrobial susceptibility testing were according to NCCLS M100-S8.1998. Screening test for Oxacillin-resistant Staphylococci was according to NCCLS M7-A4 Susceptibility test panels.
  • both MRSA and MSSA were tested on Mueller-Hinton agar plates containing varying concentrations of NGXT1914.
  • plates were prepared as above with the following concentrations of inhibitor compound: 0 ⁇ g/ml (DMSO controls), 1 ⁇ g/ml, 5 ⁇ g/ml, 10 ⁇ g/ml, and 25 ⁇ g/ml.
  • Inhibitor concentrations were prepared such that all plates contained 25 ⁇ l total DMSO.
  • 5 isolated colonies were picked from fresh overnight culture plates and used to inoculate a 0.85% NaCl solution.
  • Inhibitor NGXT 1914 inhibits growth of both resistant and sensitive Staph strains, however it is more effective against the methicillin resistant strain. This compound was tested with other cell types (mammalian cell lines, plants ( Arabidopsis thaliana ) yeast, Pseudomonas aeruginosa ) and has not inhibited growth of any cell line or organism at the concentrations tested. Since NGXT1914 is an ectophosphatase inhibitor, it is possible that Staph, particularly the MRSA, is dependent on a phosphatase that is an ideal substrate for NGXT1914. The results obtained indicated that NGXT1914 was more effective against MRSA versus MSSA than previously identified compounds.
  • SW-13 was sensitive at 20 ⁇ g/ml, whereas the vinblastine resistant line SW-13Vb003 was sensitive at 10 ⁇ g/ml.
  • SW-13 was sensitive at 30 ⁇ g/ml, whereas the vinblastine resistant line SW-13Vb003 was sensitive at 10 ⁇ g/ml.
  • SW-13 was sensitive at 50 ⁇ g/ml, whereas the vinblastine resistant line SW-13Vb003 was sensitive at 20 ⁇ g/ml.
  • psNTP9 Pisum Sativum apyrase, GenBank accession #Z32743 was subcloned as a Sall to Xbal fragment into pKYLX71 (Schardl et al, 1987, supra.). This plasmid was transformed into A. tumefaciens GV3101 [pMP90] pKYLX71 (Koncz and Shell, 1986), which was used to infect root call from Ws ecotype Arabidopsis thaliana under kanamycin selection (Valvekens et al., 1992). Four individual lines, obtained from separate calli, were propagated to the third generation (T3).
  • Subcellular Apyrase Distribution in Pea Etiolated pea plumules served as the tissue source for nuclei and cytoplasm isolation as described by Chen and Roux ( Plant Physiol. 81:609-612 (1986)).
  • Plasma membrane was prepared from 30 g of pea root tissue (Zhu Mei Jun and Chen Jia; 1995 , Acta Botanica Sinica 37:942-949).
  • Western analysis was performed on 15-30 pg of protein from cytoplasm, plasma membrane and nuclei using a polyclonal anti-apyrase antibody raised against the purified pea protein (Tong et al., 1993).
  • outside-out vesicles were prepared and the accessibility of the enzyme was determined by selective trypsin proteolysis, or membrane shaving, followed by activity assays and western blotting.
  • Phosphate uptake experiments and growth assays In all experiments the growth media did not contain sugar, and plants were grown in sterile culture at 22° C. under 150-200 pE of continuous light. Unless otherwise noted, a standard 0.8% agar medium (Becton Dickenson, Cockeysville, Md.) containing 100 ⁇ M phosphate was used for uptake assays (Somerville et al., 1982). Plants used for the phosphate uptake experiments were grown singly in 1 ml of the standard agar medium for 15 days prior to the experiment. On the day of the experiment, 10 ⁇ Ci 32 P was applied to the side of the culture dish and allowed to diffuse through the agar. The lids of 95 mm ⁇ 15 mm tissue' culture dishes (Fisher, Pittsburgh, Pa.) were removed to facilitate transpiration.
  • Detection of the pea apyrase in nuclei and in purified plasma membrane By immunoblot assay, the pea apyrase was found to be associated with nuclei and with purified plasma membranes but not with the cytoplasm ( FIG. 1A ).
  • the contents of the lanes in FIG. 1A are as follows: Lane 1, cytoplasm; Lane 2, purified plasma membrane; Lane 3, purified nuclei; and Lane 4, pre-immune control of nuclei.
  • Protease treatment destroyed both apyrase activity and antigenicity in outside-out plasma membrane vesicles. After trypsin treatment, the exterior face of the vesicle showed 30% of the ectophosphatase activity of the untreated sample. Endo-phosphatase activities were retained after trypsin treatment, indicating that the digest occurred exclusively on the exterior face of the membrane.
  • FIG. 1B Three of the four transgenic plant lines constitutively expressed psNTP9 under the control of the cauliflower mosaic virus 35S promoter and over an 18 hour period showed two to five times as much phosphate accumulation in shoots as wild type ( FIG. 1B ); Top, the total phosphate accumulated in the shoots of three independent transformants in an 18 hour 32 p uptake assay at 2 mM phosphate; Bottom, a corresponding immunoblot performed on equal amounts of protein isolated from the ECM of three week-old wild-type Arabidopsis thaliana and the psNTP9 transgenics. Apyrase expressing plants also showed four times as much phosphatase activity in the extracellular matrix as the wild-type ( FIG. 1 C ). (Note, OE 1 in the FIG. stands for over-expression 1 transgenic line).
  • Transgenic plants preferentially transport the gamma phosphate of ATP:
  • ectoapyrase was stimulating the adenosine salvage pathway
  • the intracellular uptake of adenosine was measured both in the presence and absence of the overexpression of apyrase.
  • the inability of apyrase to translocate either extracellular AMP or adenosine was demonstrated by the low level of radiolabel accumulated in the transgenic plants fed [2,8 3 H]ATP and [a 32 P]ATP ( FIG. 2 ).
  • FIG. 2A illustrates that plants overexpressing apyrase did not translocate radiolabelled adenosine (or byproducts of the dephosphorylation of [2,8 3 H]ATP) any more efficiently than plants not overexpressing apyrase (wild-type plants).
  • FIG. 2B illustrates that plants overexpressing apyrase did not translocate AMP (or the byproducts of the dephosphorylated [a 32 P]ATP) any more efficiently than wildtype plants.
  • EctoPhosphatase is Involved in Drug Resistance in Yeast and Plants
  • AtPGP-1 cDNA Arabidopsis thaliana MDR gene, accession #X61370 was subcloned into pVT101 downstream of the ADH promoter to create the AtPGP-1/pVT101 construct.
  • AtPGP-1/pVT101 and pVT101 were transformed into Saccharomyces cerevisiae INVSCI (genotype: MATa, his3- ⁇ 1, leu2, trpl-289, ura3-52) and YMR4 (genotype: MAT ⁇ his3-11,15, leu2-3, 112ura3 ⁇ 5, can Res pho5, 3::ura3A1) by a PEG lithium acetate procedure (Eble, 1992) and selected on uracil dropout medium.
  • Yeast were grown at 30° C. under conditions of constant selection for uracil auxotrophy.
  • YNB Bio101, Vista, Calif.
  • CSM uracil dropout
  • 2% glucose was used to grow strains having pVT101 constructs.
  • Cycloheximide (Sigma Chemical, St. Louis, Mo.) was added to liquid media or spread on solid media to achieve a final concentration of 500 ng/ml.
  • Nigencm (Sigma Chemical, St. Louis, Mo.) was added to liquid media or spread on solid media to achieve a final concentration of 25 ⁇ g/ml.
  • Yeast strains used in cycloheximide selection assays were always propagated in the presence of the cycloheximide on plates and then streaked onto new plates containing drug or no drug, such that induced resistance existed in each strain at the time of the start of the assay.
  • For selection assays on plates single colonies were streaked; for selection in liquid media 0.01 ml of saturated culture was added to fresh media containing the drug. The plates shown in figures were grown for 3-5 days before photographs were taken.
  • Yeast selection assays in liquid media were quantitated by turbidity as measured by absorbance at OD 600 .
  • apyrase and AtPGP-1 in plants are as described above in Example 3. Similar methods were employed to express AtPGP-1 in Arabidopsis thaliana plants with the following modifications.
  • the AtPGP-1 coding region was subcloned into a pBIN vector lacking the GUS gene as described in Sidler et al. (1998). This plasmid was then transformed into A. tumefaciens as described above, which was used to infect root calli to produce transgenic plants expressing AtPGP-1.
  • Plant growth Arabidopsis thaliana seeds were sown in a solid germination media containing MS salt, 2% sucrose, 0.8% agar, and vitamins (Valvekens et al., 1992). For selection assays, cycloheximide was spread on the media to achieve a final concentration of 250 ng/ml. Plant growth was measured by germination percentage after 6-30 days.
  • AtPGP-1 Effect of over-expression of AtPGP-1 in yeast: When a yeast mutant, YNIR4, which is deficient in two major extracellular phosphatases and tends to accumulate ATP extracellularly, was grown in a potent cellular toxin, cycloheximide, it did not grow whereas a wild-type yeast strain, INVSCI, did grow in the presence of cycloheximide ( FIG. 3A ). Surprisingly, expression of the plant multidrug resistance (MDR) gene, AtPGP-1, enabled the yeast mutant to grow in the toxin ( FIG. 3B and FIG. 5A ). The presence of AtPGP-1 in the wild-type yeast did not have any effect when grown in the presence of cycloheximide ( FIG.
  • MDR plant multidrug resistance
  • FIGS. 3C and 3D starting from the top of the dish clockwise, the cells are as follows: INVSCI (wild-type) overexpressing AtPGP-1, YNM4 containing the vector alone, YMR4 overexpressing AtPGP-1, and INVSCI containing the vector alone. When grown without drug, all the cells grow ( FIG. 3C ). However, when grown in drug, only the YMR4 containing vector alone shows reduced growth.
  • AtPGP-1 transformed strains were due to the ability of the NIDR1 channel to efflux the toxin, hence lowering the actual cellular concentration of the poison cycloheximide.
  • the sensitivity of the untransformed mutant to the drug is likely due to a loss of the ATP gradient below a point at which endogenous transporters, similar to AtPGP-1 can function.
  • AtPGP-1 Arabidopsis plants overexpressing AtPGP-1 are able to grow in both cycloheximide and cytokinin, this suggests that the conference of drug resistance by AtPGP-1 is likely to be seen with other chemicals as well and is not an isolated phenomenon.
  • Yeast cells used in the luciferase assays were grown for two days and then transferred to Lsh media at the time of the assay. From this time forward, the cells were kept at room temperature on a rotator. Every hour a 1 ml aliquot was taken, the cells in the aliquot were counted on a hemocytometer, a methylene blue viability assay was performed (Boyum and Guidotti, 1997), the cells were centrifuged, and the supernatant was stored in liquid nitrogen until all the aliquots were collected.
  • Arabidopsis thaliana plants were grown in sterile culture at 22° C.
  • luciferase buffer Analytical Luminescence Laboratory, Cockeysville, Md.
  • Luminometry Samples were reconstituted to a 100 pl final volume in FirelightTM buffer (Analytical Luminescence Laboratory, Cockeysville, Md.). After the buffer was added, all samples were kept on ice. ATP standards were reconstituted in 100 ⁇ l of FirelightTM buffer and the standards and sample were loaded into a 96-well plate and read on an automated Dynex Technologies Model MLX luminometer (Dynex Technologies, Chantilly, Va.). Samples were processed with the addition of 50 ⁇ l of FirelightTM enzyme (Analytical Luminescence Laboratory, Cockeysville, Md.) followed by a reading delay of 1.0 second and an integration time of 10 seconds. Output was taken as an average for the integration time and then averaged for multiple samples. The sample handling time was less than 2 hours.
  • Pulse Chase experiments Yeast were grown to saturation in liquid medium, as described above, centrifuged, and resuspended in fresh medium containing 1 ⁇ Ci/ml 3 H-adenosine (Amersham, Arlington Heights, Ill.). The cells were rotated at room temperature for 20 minutes to allow adenosine uptake. After 20 minutes the cells were centrifuged. The pellet was washed twice in ice cold medium, resuspended in culture medium at room temperature, divided equally between five types (five per cell line), and placed on a rotator. Every ten minutes a separate tube from each cell line was centrifuged and the pellet and supernatant were placed in separate scintillation vials. The efflux activity was expressed as the ratio of counts in the supernatant to counts in the pellet.
  • the ATP effluxed by the plant MDR1, AtPGP-1, over-expressed in yeast In wild-type cells there is a steady-state level of ATP in the extracellular fluid, which is to say that the ATP outside the cells is rapidly degraded by phosphatases and does not accumulate over time (FIG. 7 ). However, the expression of the AtPGP-1 doubled this steady-state level ( FIG. 8 ). If the yeast mutant, YMR4, which is deficient in extracellular phosphatase activity, is analyzed, there was a noticeable accumulation of ATP in the extracellular fluid compared to a control mutant transformed with empty plasmid pVT101 ( FIG. 9 ).
  • Plant Growth Arabidopsis seeds were sown in a solid germination media containing MS salts (Sigma Chemical, St. Louis, Mo.), 2% sucrose, 0.8% agar, and vitamins (Valvekens et al., 1992). For selection assays, one of the following, or a combination of both, was added to media (cooled to less than 50° C. before adding) immediately prior to pouring into plates: cycloheximide at a final concentration of 500 ng/ml; ⁇ , ⁇ -methyleneadenosine 5′-diphosphate at a final concentration of 1 mM. Plant growth was measured by germination percentage after 10-20 days.
  • FIG. 12 shows that when wild-type and AtPGP-1 overexpressing (MDR OE) Arabidopsis thaliana plants were either treated with nothing (lane 1), cycloheximide (lane 2), a,(3-methyleneadenosine 5′-diphosphate (phosphatase inhibitor) (lane 3), or cycloheximide and phosphatase inhibitor (lane 4), both the wild-type and the AtPGP-1 overexpressing plants were affected similarly by the presence of phosphatase inhibitor.
  • MDR OE wild-type and AtPGP-1 overexpressing
  • AtPGP-1 overexpressing plants grew significantly better in the presence of cycloheximide alone with a 50% germination rate for the AtPGP-1 overexpressing plants and a 2% germination rate for the wild-type plants, similar germination rates were seen for both the AtPGP-1 overexpressing and wild-type plants in the presence of either phosphatase inhibitor alone (83% and 90% germination respectively) or cycloheximide plus phosphatase inhibitor (no germination at all).
  • phosphatase inhibitor surprisingly destroys the ability of the AtPGP-expressing plants to grow in the presence of cycloheximide.
  • YMR4 MDRI is the phosphatase mutant yeast strain overexpressing AtPGP-1; YMR4 pVT011 contains vector alone; INVSC MDRI is the wild-type yeast strain overexpressing AtPGP-1; and INVSC pVT101 contains vector alone.
  • yeast strains To create drug resistant yeast strains, all four cell lines were grown up in the presence of 500 ng/ml of cycloheximide, and transferred to other cycloheximide containing plates after a period of four to six days. This transfer of cell lines and subculturing continued such that the yeast cells grew in the presence of cycloheximide for a period of at least a month.
  • Cells cultured in media alone To create cell lines that had not been preselected for their ability to grow in drug, yeast strains were grown on plates containing YNB (Bio101, Vista, Calif.) without uracil (-URA) to maintain the presence of the vector (which supplies URA) without any drugs added.
  • yeast cells were cultured in the presence of extracellular adenosine and extracellular phosphate.
  • the acid phosphatase yeast mutant, YMR4 was selected because its decreased ectophosphatase activity makes it an ideal candidate for studying the effect of extracellular nucleotides on growth. If an adenosine salvage pathway were involved, then the presence of extracellular adenosine or possibly phosphate should help cells recoup the intracellular ATP losses due to ATP/drug efflux and should help cells grow in the presence of drug whether or not the cells were overexpressing AtPGP-1.
  • Small Molecule Library A small molecule library (DIVERSet format F), which was specifically constructed to maximize structural diversity in a relatively small library (9600 compounds), was obtained from ChemBridge Corporation (San Diego, Calif.). The small molecules (supplied in 0.1 mg dehydrated aliquots) were dissolved in DMSO, transferred to a 96 well plate, and tested for their ability to inhibit apyrase activity.
  • DIVERSet format F DIVERSet format F
  • the assay A stringent screen to test the ability of small molecules to disrupt the ATPase activity of the apyrase enzyme was developed based on phosphate-mobylate complexation.
  • the assay was a modification of a phospholipase assay developed by Hergenrother et al. (1997): Under normal conditions, the apyrase enzyme liberates phosphate from ATP present in the reaction. The liberated phosphate quickly forms a complex upon addition of a small amount of acidified molybdate and ascorbate allowing for the production of a very dark blue color (the less phosphate liberated, the less blue color). Control reactions were performed with heat inactivated apyrase enzyme.
  • reaction buffer 60 mM HEPES, 3 MM MgCl 2 , 3 mM CaCl 2 , 3 mM ATP pH 7.0
  • apyrase potato apyrase grade VI, Sigma Chemical, St. Louis, Mo.
  • enzyme 0.1 units was added in a 5 pI volume and the reaction was allowed to proceed at room temperature for 60 minutes.
  • Buffer A 2% Ammonium molybdate in water
  • Buffer B 1 I% Ascorbic acid in 37.5% aqueous TCA.
  • Buffer C 2% trisodium citrate, 2% acetic acid.
  • buffers A and B were mixed in a 1:1 5 ratio. 50 pl of A:B was added to each well. The 96 well plate was then vibrated on a table surface to mix the solution. The deep blue color developed after approximately 2 minutes. After 2 minutes, 50 p.l of buffer C was added to each well and the blue color became darker, increasing the sensitivity of the assay. The color intensified for up to one hour with no accompanying color change in the control wells containing heat inactivated apyrase enzyme. The color intensity for a single plate was measured on an Alpha Imager 2000 with AlphaEaseTM software (Alpha Innotech, San Leandro, Calif.).
  • compositions and methods disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure. While the compositions and methods of this invention have been described in terms of preferred embodiments, it will be apparent to those of skill in the art that variations may be applied to the compositions and methods and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the invention. More specifically, it will be apparent that certain agents which are both chemically and physiologically related may be substituted for the agents described herein while the same or similar results would be achieved. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims.

Abstract

The invention provides methods and compositions for modulating the sensitivity of cells to cytotoxic compounds and other active agents. In accordance with the invention, compositions are provided comprising combinations of ectophosphatase inhibitors and active agents. Active agents include antibiotics, fungicides, herbicides, insecticides, chemotherapeutic agents, and plant growth regulators. By increasing the efficacy of active agents, the invention allows use of compositions with lowered concentrations of active ingredients.

Description

    BACKGROUND OF THE INVENTION
  • 1. Field of the Invention
  • The present invention relates generally to the fields of cellular biology. More particularly, it concerns methods and compositions for the modulation of cellular sensitivity to biologically-active agents.
  • 2. Description of Related Art
  • Transport Processes
  • Cells can use a phenomenon called symport to move soluble products across biological membranes. Symport is a form of coupled movement of two solutes in the same direction across a membrane by a single carrier. Examples of proton and sodium-linked symport systems are found in nearly all living systems. The energetics of the transport event depend on the relative size and electrical nature of the gradient of solutes.
  • Transport processes have been classified on the basis of their energy-coupling mechanisms. Currently there are four classifications: (1) Primary Active Transport which uses either a chemical, light or electrical energy source, (2) Group Translocation which uses chemical energy sources, (3) Secondary Active Transport which uses either a sodium or proton electrochemical gradient energy source, and (4) Facilitated Diffusion which does not require an energy source (Meyers, 1997). The present invention is related to transport molecules belonging to the first class of transport processes, primary active transport, and therefore, this type of transport will be discussed in further detail.
  • Primary active transport refers to a process whereby a “primary” source of energy is used to drive the active accumulation of a solute into or extrusion of a solute from a cell. Transport proteins include P-type ATPases and ABC-type ATPases, as well as V-type and E-type ATPases. These types of transport systems are found in both eukaryotes and prokaryotes. The bacterial ABC-type transporters, which are ATP-driven solute pumps, have eukaryotic counterparts. Additionally, many transmembrane solute transport proteins exhibit a common structural motif. The proteins in these families consist of units or domains that pass through the membrane six times, each time as an α-helix. This has led to the suggestion that many transport proteins share a common evolutionary origin, but this is not true of several distinct families of transport proteins.
  • Numerous structurally distinct bacterial permeases, as well as several homologous eukaryotic transport systems, share a common organization (Meyers, 1997). Two hydrophilic domains or proteins function to couple ATP hydrolysis in the cytoplasm to activate substrate uptake or efflux, and two hydrophobic domains or proteins function as the transmembrane substrate channels. These proteins or protein domains constitute what is referred to as the ABC (ATP-binding cassette) superfamily. Either the two hydrophilic domains or proteins or the two hydrophobic domains or proteins (or both) may exist either as heterodimers or homodimers. If, as in most bacterial systems, each of these constituents is a distinct protein, then either two, three, or four genes will code for them, depending on whether both are homodimers, one is a homodimer and one is a heterodimer, or both are heterodimers, respectively. The best characterized of the eukaryotic proteins included in this family are the multidrug-resistance (MDR) transporter and the cystic fibrosis related chloride ion channel of mammalian cells (cystic fibrosis transmembrane conductance regulator or CFTR) (Meyers, 1997).
  • Multidrug Resistance
  • Multidrug resistance (MDR) is a general term that refers to the phenotype of cells or microorganisms that exhibit resistance to different, chemically dissimilar, cytotoxic compounds. MDR can develop after sequential or simultaneous exposure to various drugs. MDR can also develop before exposure to many compounds to which a cell or microorganism may be found to be resistant. MDR which develops before exposure is frequently due to a genetic event which causes the altered expression and/or mutation of an ATP-binding cassette (ABC) transporter (Wadkins and Roepe, 1997). This is true for both eukaryotes and prokaryotes.
  • One prominent member of the ABC family, P-glycoprotein (Pgp; also known as multidrug resistance protein or MDR1), which is a plasma-membrane glycoprotein that confers a multidrug resistance (MDR) phenotype on cells, is of considerable interest because it provides one mechanism of possibly inhibiting resistance in tumor cells to chemotherapeutic agents (Senior et al., 1995). Pgp is a single polypeptide of ˜1280 amino acids with the typical ABC transporter structure profile. Studies have shown that over expression of Pgp is responsible for the ATP-dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells (Abraham et al., 1993).
  • Over one-hundred ABC transporters have been identified in species ranging from Escherichia coli to humans (Higgins, 1995). For example, the bacteria Lactococcus lactis expresses an ABC transporter, LmrA, which mediates antibiotic resistance by extruding amphiphilic compounds from the inner leaflet of the cytoplasmic membrane (Van Veen et al., 1998). Furthermore, over-expression of LmrA can confer MDR in human lung fibroblasts and LmrA has similar molecular and biochemical properties to Pgp. This demonstrates that bacterial LmrA and Pgp are functionally interchangeable. Additionally, the plant Arabidopsis thaliana encodes an ATP transporter, AtPGP-1, which is a putative Pgp homolog (Dudler and Hertig, 1992). Similarly, the yeast Saccharomyces cerevisiae equivalent of Pgp, STS1 (Bissinger and Kucher, 1994) has been cloned and shown to confer multidrug resistance when over-expressed in yeast, as has the yeast Pdr5p (Kolacskowski et al., 1996). Taken together, these results suggest, that this type of multidrug resistance efflux pump is conserved from bacteria to humans.
  • While various theories of ABC transporter function have become popular, there is still no precise molecular-level description for the mechanism by which over-expression lowers intracellular accumulation of drugs, in particular how Pgp lowers intracellular accumulation of chemotherapeutic drugs. However, it has been shown that Pgp over-expression also changes plasma membrane electrical potential and intracellular pH which could potentially greatly affect the cellular flux of a large number of compounds to which Pgp confers resistance (Wadkins and Roepe, 1997). Also included in the ABC transporter superfamily are the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and the Sulfonyl Urea Receptor (SUR). CFTR and SUR are expressed in the lung epithelium and the β cells of the pancreas, respectively, as well as in other tissues. CFTR functions as a low conductance ATP and cyclic AMP-dependent Clchannel that also appears to have additional important functions, such as modulation of epithelial NA+ regulation of outwardly rectified chloride channels (Wadkins and Roepe, 1997).
  • Mutations in the CFTR gene produce altered CFTR proteins with defects in CFTR function, leading to profound alterations in epithelial salt transport and altered mucous properties in cystic fibrosis patients that result in chronic lung infections associated with the disease. Id. SUR is triggered by sulfonyl urea drugs to depolarize pancreatic P cells that leads to Ca2+ influx, which stimulates fusion of insulin containing vesicles to the plasma membrane. Id. An ATP transporter hypothesis has been suggested for Pgp, CFTR and SUR which theorizes that these ABC transporters function as ATP transport channels (Abraham et al., 1993; Schweibert, 1995; Al-Awgati, 1995). The ATP channel hypothesis, however, has been viewed with skepticism. This is partly due to the inability to show the same results with preparations including purified and reconstituted CFTR, suggesting that the ATP conductance that was originally observed may have been mediated by another protein, not present in the purified system, that is influenced by CFTR (Wadkins and Roepe). There has been no such negative data reported with respect to the ATP charnel hypothesis for Pgp or SUR, but the controversy over CFTR has raised doubt for Pgp and SUR as well.
  • In support of the ATP channel hypothesis (Huang et al., 1992) have suggested that extracellular ATP leads to elevations in pH, and Weiner et al., (1986) have suggested that extracellular ATP may regulate Na/H+ exchange in Ehrlich ascites tumor cells. It has also been observed that changes in Pgp levels affects pH and plasma membrane electrical potentials which could be connected to recent observations suggesting the involvement of ATP transport in MDR.
  • Additionally, Abraham et al., (1993) have reported that the addition of extracellular ATP to MDR cell lines confers sensitivity to drugs abolishing MDR. The data for this effect were not presented in the article and no further explanation was given for this phenomenon. Furthermore, there have been no subsequent publications addressing or explaining this effect.
  • Furthermore, Ujhazy et al., (1996) have shown that ecto-5′-nucleotidase is up-regulated in certain MDR cell lines. Ecto-5′-nucleotidase is the final enzyme in the extracellular pathway for salvage of adenosine from phosphorylated purines (Zimmerman, 1992). The proposed hypothesis for the involvement of ecto-5′-nucleotidase in drug resistance considers its role in the maintenance of intracellular ATP pools through the adenosine salvage pathway (Ujhazy et al., 1996). Ecto-5′-nucleotidase specifically acts in adenosine salvage pathways, converting AMP to adenosine which is more readily taken up by the cell and utilized as a precursor for ATP production. Therefore, ecto-5′-nucleotidase may be acting in certain MDR cell lines as a mechanism by which the cell circumvents the loss of ATP (due to up-regulated transport proteins which possibly form ATP transport channels) by creating higher levels of adenosine from which the cell can produce ATP. Correspondingly, 63% of MDR cell line variants tested expressed ecto-5′-nucleotidase. These observations suggested that a salvage mechanism for extracellular nucleotides may be another way by which certain MDR cells counterbalance their ATP losses from efflux induced by the over-expression of ABC transporters involved in MMR. Consistent with this hypothesis, inhibitors of ecto-5′-nucleotidase conferred sensitivity to certain drugs in MDR cell lines which over-express the ecto-5′-nucleotidase.
  • It is also interesting to note that yeast, which do not have an adenosine salvage pathway (Boyum and Guidotti, 1997), do contain a PGP-like gene called STS 1 (Bissinger and Kucher, 1994). Therefore, since the adenosine salvage pathway is unlikely to be involved in yeast multidrug resistance, other mechanisms are likely to exist.
  • Recent reports have confirmed the existence of ATP in the extracellular matrix (ECM) of both multicellular organisms and unicellular organisms (Sedaa et al., 1990; Boyum and Guidotti, 1997), respectively. However, no such reports are available which suggest the existence of ATP in the ECM of plants before the present invention. These reports have prompted further investigations of the fate of ATP outside the cell. One of the largest gradients in biological systems is that of ATP. It is a million-fold more concentrated inside the cell than outside. Phosphatases are enzymes with the ability to hydrolyze ATP and to a lesser extent, the beta phosphate of ADP (Plesner, 1995). Extracellular phosphatases are generally referred to as ectophosphatases A type of ectophosphatase is ecto-pyrase. Given reports that show the existence of extracellular ATP, one observation regarding ectoapyrase is that it hydrolyzes the extracellular ATP. In fact, work in animal systems has shown that apyrases hydrolyze ATP in the ECM as part of the adenosine salvage pathway conjointly with ecto-5′ ectonucleotidase (Che, 1992).
  • What has been lacking in the art are particular methods and compositions that allow modification of cellular ATP gradients to increase the uptake of cytotoxic agents by cells. It would be particularly useful to identify methods and compositions that result in increased uptake by cells of herbicides, antibiotics, fungicides, insecticides, chemotherapeutics and other active ingredients. This may result in increased efficacy in the use of such agents, as well as allow use of lower concentrations of such agents. This may provide cost, health and environmental benefits. This may also allow effective treatment of MDR cells, such as antibiotic-resistant bacteria or chemotherapy-resistant tumor cells.
  • SUMMARY OF THE INVENTION
  • In one aspect, the invention provides a cytotoxic composition comprising an ectophosphatase inhibitor and a cytotoxic agent set forth in Table 1. In one embodiment of the invention, the cytotoxic agent is selectively cytotoxic. In other embodiments, the cytotoxic composition may be further defined as a herbicidal composition and the cytotoxic agent a herbicide, may be further defined as an insecticidal composition and the cytotoxic agent an insecticide, may be further defined as a fungicidal composition and the cytotoxic agent a fungicide and/or may be further defined as an antibiotic composition and the cytotoxic agent an antibiotic. In an antibiotic composition, the antibiotic may be from a class selected from the group consisting of Beta-lactam, Semisynthetic penicillin, Clavulanic Acid, Monobactams, Carboxypenems, Aminoglycosides, Glycopeptides, Lincomycins, Macrolides, Polyenes, Rifamycins, Tetracyclines, Semisynthetic, tetracycline and Chloramphenicol. In certain embodiments of the invention, the ectophosphatase inhibitor may be selected from the group consisting of the compounds of formulae I-XX.
  • In another aspect, the invention provides a plant growth regulator composition comprising an ectophosphatase inhibitor and a plant growth regulator agent set forth in Table 1. In one embodiment of the invention, the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulae I-XX.
  • In yet another aspect, the invention provides a chemotherapeutic composition comprising an ectophosphatase inhibitory compound and a chemotherapeutic agent. In one embodiment of the invention, the chemotherapeutic agent is a chemotherapeutic agent set forth in Table 3. In further embodiments of the invention, the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulae I-XX.
  • In still yet another aspect, the invention provides a method of killing or inhibiting the growth of a plant, comprising contacting said plant with an effective amount of a herbicidal composition provided by the invention. The method may be carried out with potentially any plant, including a monocotyledonous plant or a dicotyledonous plant.
  • In still yet another aspect, the invention provides a method of killing or inhibiting the growth of a tumor cell, comprising contacting said tumor cell with an effective amount of a chemotherapeutic composition of the invention. In the method, contacting may comprise administering the composition to a patient in need thereof, wherein the patient comprises the tumor cell.
  • In still yet another aspect, the invention provides a method of killing or inhibiting the growth of a target cell, comprising contacting said cell with a composition formulated therefore. In certain embodiments of the invention, the cell may be a fungal cell, bacterial cell, or insect cell.
  • In still yet another aspect, the invention provides a method of increasing the effectiveness of a cytotoxic agent, comprising admixing said cytotoxic agent with an ectophosphatase inhibitor, wherein the cytotoxic agent is selected from the group set forth in Table 1. In certain embodiments of the invention, the cytotoxic agent may be further defined as a herbicide, insecticide, fungicide, and an antibiotic. Examples of antibiotics include those from the following classes: Beta-lactam, Semisynthetic penicillin, Clavulanic Acid, Monobactams, Carboxypenems, Aminoglycosides, Glycopeptides, Lincomycins, Macrolides, Polyenes, Rifamycins, Tetracyclines, Semisynthetic, tetracycline and Chloramphenicol. In one embodiment of the invention. In one embodiment of the invention, a cytotoxic agent is a chemotherapeutic agent, for example, selected from the group set forth in Table 3.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The following drawings form part of the present specification and are included to further demonstrate certain aspects of the present invention. The invention may be better understood by reference to one or more of these drawings in combination with the detailed description of specific embodiments presented herein.
  • FIGS. 1A-1C Expression of apyrase in pea and in transgenic plants (FIG. 1A) Immunoblot analysis of subcellular fractions from etiolated pea plants. (FIG. 1B) Top, the total phosphate accumulated in the shoots of three independent transgenic plants. Bottom, a corresponding Immunoblot performed on protein from ECM of wild-type and transgenic plants. (FIG. 1C) Assay of phosphatase activity in the ECM fraction of OE1 and wild-type.
  • FIGS. 2A-C Transport of the products of ATP hydrolysis by transgenic plants overexpressing apyrase and by wild-type plants.
  • FIGS. 3A-D Conference of resistance to cycloheximide (FIG. 3A, B) and nigencin (FIG. 3C, D) in wild-type and ectophosphatase deficient yeast over-expressing the Arabidopsis plant ABC transporter, AtPGP-1.
  • FIGS. 4A-B-3 Conference of resistance to cycloheximide (FIG. 4A) and cytokinin (FIG. 4B-1-FIG. 4B-3) in Arabidopsis plants over-expressing either the ectophosphatase, apyrase, or the ABC transporter, AtPGP-1.
  • FIGS. 5A-B Graph showing the growth turbidity of YMR4 yeast over-expressing the Arabidopsis plant ABC transporter AtPGP-1 grown in cycloheximide (FIG. 5A) or nigericin (FIG. 5B).
  • FIG. 6 Graph showing germination rate of Arabidopsis plants grown in the presence of cycloheximide which over-express either the ectophosphatase, apyrase, or the ABC transporter AtPGP-1.
  • FIG. 7 Graph of steady-state levels of ATP in the extracellular fluid of wildtype yeast cells grown in the presence or absence of glucose and in the presence or absence of over-expression of the Arabidopsis plant ABC transporter, AtPGP-1.
  • FIG. 8 Graph showing that over-expression of Arabidopsis plant ABC transporter, AtPGP-1, in yeast can double the steady-state levels of ATP in the extracellular fluid.
  • FIG. 9 Graph showing that a yeast mutant, YMR4, that has a deficient ectophosphatase, accumulates ATP in the extracellular fluid and the over-expression of AtPGP-1 increases the accumulation of ATP.
  • FIG. 10 Graph showing results of a pulse-chase experiment in either wildtype yeast cells or a yeast mutant, YMR4, which is deficient in ectophosphatase activity, in the presence and absence of over-expression of Arabidopsis plant ABC transporter, AtPGP-1, demonstrating an early differential ATP efflux of cells over-expressing AtPGP-1.
  • FIG. 11 Graph of ATP levels on the surface of leaves of Arabidopsis plants over-expressing AtPGP-1 (MDR 1).
  • FIG. 12 Effects of phosphatase inhibitor in wild-type and AtPGP-1 (MDRI) overexpressing Arabidopsis plants.
  • FIG. 13 Growth effects of cycloheximide and extracellular ATP on wildtype and MDR1 overexpressing S. cerevisiae yeast cells which have either never seen cycloheximide or which have been previously selected in cycloheximide.
  • FIG. 14 Growth effects of cycloheximide, adenosine and phosphate on wildtype and AtPGP-1 overexpressing S. cerevisiae yeast cells.
  • DETAILED DESCRIPTION OF THE INVENTION
  • The present invention provides methods and compositions for modulating the sensitivity of cells to cytotoxic compounds and other active agents. In accordance with the invention, such modulation may be carried out by modifying cellular ATP gradients, for example, by contacting a plant, animal, yeast or bacterial cell with an ectophosphatase inhibitor contemporaneously with a cytotoxic agent or other active ingredient, or combinations thereof. As used herein, the term “ectophosphatase inhibitor” refers to a compound that has the ability to specifically inhibit ectophosphatase activity. A “cytotoxic agent” is a compound capable of selectively or non-selectively killing or inhibiting the growth of a cell, including antibiotics, fungicides, herbicides, insecticides and chemotherapeutic agents.
  • The efficacy of one or more cytotoxic agents may be increased in accordance with the invention by reducing the ATP gradient across biological membranes, which is effectuated through the modulation of an ectophosphatase either alone or together with an ABC transporter molecule. Modulation of resistance to a cytotoxic compound as described herein is useful, for example, in increasing the sensitivity of plants to herbicides; reducing drug resistance in tumor cells for improved chemotherapy applications; and reducing resistance to antibiotics, antifungal agents, insecticides and other cytotoxic agents for the treatment of infections and disease. Provided by the invention are specific combinations of ectophosphatase inhibitors and cytotoxic compounds or other active ingredients that may be used in these applications.
  • In accordance with certain embodiments of the invention, the manipulation of extracellular ATP levels to alter ATP gradient across biological membranes in cells by inhibition of ectophosphatases results in diminishing or removing the ATP gradient that may otherwise prevent access of cytotoxic agents to the cell. In some instances, access may be minimized by efflux of cytotoxic agents from the cell. This efflux is likely effectuated through the “piggy-back” efflux of drug molecules with ATP, a phenomenon known as symport.
  • In accordance with the invention, inhibitors of ectophosphatases may be administered contemporaneously with cytotoxic agents, including herbicides, antibiotics, fungicides, insecticides and other active ingredients, as well as chemotherapeutics. By “contemporaneously,” it is meant within sufficient temporal proximity that the increased sensitivity of a cell to the relevant cytotoxic agent may be achieved in combination with contacting the cell with the agent. In certain embodiments of the invention, ectophosphatase inhibitors are used as adjuvants with cytotoxic agents, that is, are admixed with one or more cytotoxic agents or other active ingredients.
  • It is therefore an, object of the present invention to provide inhibitors of ectophosphatases in physiological compositions for modulating cell growth and/or survival, including, but not limited to, MDR cells. Such physiological compositions may comprise a small molecule capable of inhibiting an ectophosphatase and a physiologically acceptable carrier or diluent together with a therapeutic agent. As used herein, the term “physiologically acceptable carrier or diluent” means any and all solvents, dispersion media, antibacterial and antifungal agents, microcapsules, liposomes, cationic lipid carriers, isotonic and absorption delaying agents and the like which are not incompatible with the ectophosphatase inhibitors. The use of such media and agents for physiologically active substances is well known in the art. Supplementary active ingredients may also be incorporated into the compositions.
  • In certain embodiments, only an endogenous ectophosphatase is inhibited. In particular embodiments of the invention, the ectophosphatase is human apyrase. In other embodiments, the ectophosphatase is a plant, bacterial, fungal or yeast ectophosphatase.
  • The inhibition of ectophosphatases is useful in increasing sensitivity to cytotoxic agents and/or reduction of drug resistance in cells. In one embodiment of the invention, the inhibition of ectophosphatases results in a loss of resistance to a cytotoxic agent. In another embodiment of the invention, administration of such inhibitory molecules is in conjunction with the administration of chemotherapeutic agents in tumor cells.
  • Using high throughput screens, ectophosphatase inhibitors may be isolated, for example, by screening a small molecule library (e.g. a combinatorial library) for inhibitory activity to ectophosphatase (e.g. apyrase activity). Once ectophosphatase inhibitory molecules are isolated from such a screen, the inhibitors may be further tested for their ability to specifically inhibit the ATPase activity of the ectophosphatase.
  • Exemplary ectophosphatase inhibitory molecules for use with the current invention are preferably chemically stable and physiologically active including, but not limited to, the compounds of formulae I-XX.
    Figure US20060276339A1-20061207-C00001
    Figure US20060276339A1-20061207-C00002
  • Preliminary pharmacophore studies revealed that the small molecules represented by Formulae I through XX fall into five classes of compounds (sulfanamides, guanidines, aminothiazoles, thioketones and benzamides). Most of these chemical classes are found in other physiologically-active compounds, including those having pharmaceutical and therapeutic use. For example, sulfanimides are widely used as antibiotics. Additionally, studies for the isolation of small molecules capable of reversing MDR have described molecules belonging to two of the classes of molecules of the present invention (Medina et al. 1998; Dhamant et al., 1992). The molecules described by Medina et al. have been shown to affect MDR and the mode of action of the molecules is believed to involve tubulin interactions. The thiazine derivatives described by Dhamant et al. reverse the resistance in tumor cells to vincristine.
  • The ectophosphatase inhibitory molecules are useful in increasing the activities of various agents by increasing the availability of the agents to cells. In certain embodiments of the invention, this may comprise reversing multidrug resistance (MDR) in an organism. In other embodiments, this may be achieved with a cell that does not exhibit MDR. Such cells may or may not comprise an up-regulated ectophosphatase
  • MDR reversal and/or increasing of sensitivity to a cytotoxic agent in cells may be shown by growing the cells in the presence of relevant drugs and in the presence and absence of the inhibitor. Cells which cannot grow in the presence of a drug in the presence of an ectophosphatase inhibitor, have a reversal in MDR and/or increase in sensitivity to the agent.
  • The ectophosphatase inhibitory compositions of the present invention are useful in reversing drug resistance in mammalian cell lines grown in the presence of a drug (e.g. a chemotherapeutic agent). Analysis of sensitivity to a chemotherapeutic composition in mammalian cells may be shown, for example, by using the fluorescent compound calcein-AM. Esterases present in cells cleave the aceto-methoxy ester (AM) from the calcein-AM and liberate calcein. Calcein is a fluorescent compound which is excitable by the 488 nm laser of a FACS Caliber flow cytometer (Becton Dickenson, Franklin Lakes, N.J.), while the uncleaved calcein-AM is not excitable. Wild type cells incubated in the presence of calcein-AM show a high level of fluorescence while MDR state cells, which efflux the calcein-AM faster than the cellular esterases can cleave it, do not show a high level of fluorescence. The mammalian cells can be tested for the reversal of MDR with ectophosphatase inhibitors by the amount of calcein fluorescence detected in the cells.
  • Specificity of ectophosphatase inhibitors may be tested with the screening assays described herein. Inhibitors can be tested for their ability to inhibit acid phosphatases, alkaline phosphatases, myosin phosphatases and the luciferase ATPase. The assays may be performed using techniques known in the art.
  • In one embodiment of the invention, the ectophosphatase is an apyrase and the ectophosphatase inhibitor is a molecule selected from among molecules represented by the Formulae I through XX. In another embodiment, the ectophosphatase is apyrase and the ectophosphatase inhibitor is a molecule selected from among molecules represented by the Formulae I through V.
  • In a further embodiment of the invention, the ectophosphatase is apyrase and the ectophosphatase inhibitor is a molecule represented by Formula XX. Formula XX is suramin or 8,8′[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl imino]]bis-1,3,5-naphthalenetrisulfonic acid. Suramin has been reported as a potent non-competitive inhibitor of ectoapyrase activity associated with the plasma membrane of cholinergic nerve terminal of Torpedo mannorata electric organs (arti et al., 1996).
  • It is contemplated that in certain embodiments of the invention an ectophosphatase inhibitor may inhibit an ectophosphatase active on the outer membrane of an organelle of a eukaryotic cell. In this manner, contacting the cell with the ectophosphatase inhibitor may be used to decrease the ATP gradient across the organelle and thereby facilitate uptake of a biologically active agent by the organelle.
  • I. Formulations
  • Ectophosphatase inhibitor compositions, which may be acidic or basic in nature, can form a wide variety of salts with various inorganic and organic bases or acids, respectively. These salts may be physiologically acceptable for in vivo administration in mammals, including humans, as well as formulations for ex vivo applications, including agricultural use. Salts of acidic compounds are readily prepared by treating the acidic compound with an appropriate molar quantity of the chosen inorganic or organic base in an aqueous or suitable organic solvent and then evaporating the solvent to obtain the salt. Salts of basic compounds can be obtained similarly by treatment with the desired inorganic or organic acid and subsequent solvent evaporation and isolation. The skilled artisan can produce salts of ectophosphatase inhibitors using techniques known in the art.
  • The skilled artisan readily can determine the amount of the ectophosphatase inhibitor that is required to inhibit ectophosphatase by measuring ATPase activity in the presence and absence of varying amounts of the inhibitor. Phosphatase activity can be determined by assessing the dephosphorylation of ATP and liberation of phosphate as described herein. Additionally, parameters may be measured that are known to be associated with ectophosphatase activity to determine whether the molecule has ectophosphatase inhibitory activity. For example, ectophosphatase inhibitory activity may be measured in cells (e.g., yeast, plant, bacterial, mammalian, and tumor cell lines) by assessing the loss of resistance to drugs. Furthermore, the ectophosphatase inhibitory molecules of the present invention may be tested for specific inhibitory activity to ectophosphatases versus general phosphatases or for specific inhibitory activity for a particular ectophosphatase activity (e.g., apyrase).
  • The present invention also provides physiologically acceptable compositions comprising an ectophosphatase inhibitor, a cytotoxic agent or other active ingredient and a physiologically acceptable carrier or diluent. In certain embodiments of the invention, as set forth in detail below, compositions are provided comprising one or more ectophosphatase inhibitor and one or more plant growth regulator, herbicide, fungicide, insecticide, antibiotic, chemotherapeutic agent or other active compound. In a further embodiment of the invention, the ectophosphatase is selected from the compounds of formulae I-XX in the appropriate carriers, diluents or other active ingredients.
  • The use of physiologically acceptable carriers or diluents is well known in the art. The techniques of preparation of pharmaceutical compositions are generally well known in the art as exemplified by Remington's Pharmaceutical Sciences, 16th Ed. Mack Publishing Company, 1980, which reference is specifically incorporated herein by reference in its entirety. Formulations of the present invention may be stable under the conditions of manufacture and storage and must be preserved against contamination by microorganisms.
  • The physiological forms of the compositions of the invention suitable for administration include sterile aqueous solutions or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersions. Typical carriers include a solvent or dispersion medium containing, for example, water buffered aqueous solutions (i.e., biocompatible buffers), ethanol, polyols such as glycerol, propylene glycol, polyethylene glycol, suitable mixtures thereof, surfactants, and vegetable oils. Isotonic agents such as sugars or sodium chloride may be incorporated into the subject compositions.
  • Pharmaceutical compositions in accordance with the invention may be used by themselves or in combination with other forms active ingredients or therapeutics. One embodiment of the invention provides formulations for parenteral administration, e.g., formulated for injection via the intravenous, intramuscular, sub-cutaneous or other such routes. Typically, such compositions can be prepared as injectables, either as liquid solutions or suspensions; solid forms suitable for using to prepare solutions or suspensions upon the addition of a liquid prior to injection also can be prepared; and the preparations also can be emulsified.
  • Solutions of the active compounds as free base or pharmacologically acceptable salts can be prepared in water suitably mixed with a surfactant, such as hydroxypropylcellulose. Dispersions also can be prepared in glycerol, liquid polyethylene glycols, and mixtures thereof and in oils. Under ordinary conditions of storage and use, these preparations contain a preservative to prevent the growth of microorganisms.
  • The pharmaceutical forms suitable for injectable use include sterile aqueous solutions or dispersions; formulations including sesame oil, peanut oil or aqueous propylene glycol; and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersions. In all cases, the form must be sterile and must be fluid to the extent that easy syringability exists. It must be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms, such as bacteria and fungi.
  • Carriers used also can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), suitable mixtures thereof, and vegetable oils. The proper fluidity can be maintained, for example, by the use of a coating, such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants. The prevention of the action of microorganisms can be brought about by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, sorbic acid, thimerosal, and the like. In many cases, it will be preferable to include isotonic agents, for example, sugars or sodium chloride. Prolonged absorption of the injectable compositions can be brought about by the use in the compositions of agents delaying absorption, for example, aluminum monostearate and gelatin.
  • Sterile injectable solutions are prepared by incorporating the active compounds in the required amount in the appropriate solvent with various of the other ingredients enumerated above, as required, followed by filtered sterilization. Generally, dispersions are prepared by incorporating the various sterilized active ingredients into a sterile vehicle which contains the basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, the preferred methods of preparation are vacuum-drying and freeze-drying techniques which yield a powder of the active ingredient plus any additional desired ingredient from a previously sterile-filtered solution thereof.
  • Other modes of administration can also find use with the invention. For instance, pharmaceutical compounds may be formulated in suppositories and, in some cases, aerosol and intranasal compositions. For suppositories, the vehicle composition will include traditional binders and carriers such as polyalkylene glycols or triglycerides. Such suppositories may be formed from mixtures containing the active ingredient in the range of about 0.5% to about 10% (w/w), preferably about 1% to about 2%.
  • Ectophosphatase inhibitors will commonly comprise from less than 1% to about 10% w/v of a composition with an active ingredient, including about 1%, 3%, 5%, &% and about 10%. Greater or lesser amounts of the ectophosphatase inhibitors may similarly be used. Desired concentrations may readily be determined by serial preparation and assay of compositions comprising varying amounts of the selected ectophosphatase inhibitor compound. For example, in the case of herbicidal compositions, a series of test compositions comprising from about 0.1% to about 25% w/v of an ectophosphatase inhibitor together with a test herbicide may be analyzed by leaf painting and comparison of the results. Safety, efficacy, cost and other concerns may each be taken into account in selecting the desired concentrations. Alternatively, pharmaceutical compositions may be analyzed using in vitro or in vivo models.
  • Oral compositions may be prepared in the form of solutions, suspensions, tablets, pills, capsules, sustained release formulations, or powders. These compositions can be administered, for example, by swallowing or inhaling. Where a pharmaceutical composition is to be inhaled, the composition will preferably comprise an aerosol. Exemplary procedures for the preparation of aqueous aerosols may be found in U.S. Pat. No. 5,049,388, the disclosure of which is specifically incorporated herein by reference in its entirety. Preparation of dry aerosol preparations are described in, for example, U.S. Pat. No. 5,607,915, the disclosure of which is specifically incorporated herein by reference in its entirety.
  • Also useful is the administration of the compounds described herein directly in transdermal formulations with permeation enhancers such as DMSO. These compositions can similarly include any other suitable carriers, excipients or diluents. Other topical formulations can be administered to treat certain disease indications. For example, intranasal formulations may be prepared which include vehicles that neither cause irritation to the nasal mucosa nor significantly disturb ciliary function. Diluents such as water, aqueous saline or other known substances can be employed with the subject invention. The nasal formulations also may contain preservatives such as, but not limited to, chlorobutanol and benzalkonium chloride. A surfactant may be present to enhance absorption of the subject compounds by the nasal mucosa.
  • Upon formulation, solutions may be administered in a manner compatible with the dosage formulation and in such amount as is therapeutically effective. The formulation of choice can be accomplished using a variety of excipients including, for example, pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, sodium saccharin cellulose, magnesium carbonate, and the like. Typically, pharmaceutical compositions will contain from less than 1% to about 95% of the active ingredient, preferably about 10% to about 50%. Preferably, between about 10 mg/kg patient body weight per day and about 25 mg/kg patient body weight per day will be administered to a patient, including a human patient. The frequency of administration will be determined by the care given based on patient responsiveness. Other effective dosages can be readily determined by one of ordinary skill in the art through routine trials establishing dose response curves.
  • Regardless of the mode of administration, suitable pharmaceutical compositions in accordance with the invention will generally include an amount of active ingredient admixed with an acceptable pharmaceutical diluent or excipient, such as a sterile aqueous solution, to give a range of final concentrations, depending on the intended use. The techniques of preparation are generally well known in the art as exemplified by Remington's Pharmaceutical Sciences, 16th Ed. Mack Publishing Company, 1980, which reference is specifically incorporated herein by reference in its entirety. It should be appreciated that endotoxin contamination should be kept minimally at a safe level, for example, less that 0.5 ng/mg protein. Moreover, for human administration, preparations should meet sterility, pyrogenicity, general safety and purity standards as required by FDA Office of Biological Standards.
  • The therapeutically effective doses are readily determinable using an animal model. For example, experimental animals exhibiting a target infection or other ailment are frequently used to optimize appropriate therapeutic doses prior to translating to a clinical environment. Such models are known to be very reliable in predicting effective therapies. In certain embodiments, it may be desirable to provide a continuous supply of therapeutic compositions to the patient. For intravenous or intraarterial routes, this is accomplished by drip system. For topical applications, repeated application would be employed. For various approaches, delayed release formulations could be used that provided limited but constant amounts of the therapeutic agent over and extended period of time. For internal application, continuous perfusion of the region of interest may be preferred. This could be accomplished by catheterization, post-operatively in some cases, followed by continuous administration of the therapeutic agent. The time period for perfusion would be selected by the clinician for the particular patient and situation, but times could range from about 1-2 hours, to 2-6 hours, to about 6-10 hours, to about 10-24 hours, to about 1-2 days, to about 1-2 weeks or longer. Generally, the dose of the therapeutic composition via continuous perfusion will be equivalent to that given by single or multiple injections, adjusted for the period of time over which the injections are administered. It is believed that higher doses may be achieved via perfusion, however.
  • Therapeutic kits comprising the compositions described herein are also provided by the invention. Such kits will generally contain, in suitable container means, a pharmaceutically or agriculturally acceptable formulation of the active ingredient. The kits also may contain other pharmaceutically acceptable formulations, such as an antiinfective agent, including an insecticide, antifungal or antibacterial, as well as a herbicide.
  • The kits may have a single container means that contains the active ingredient, with or without any additional components, or they may have distinct container means for each desired agent. When the components of the kit are provided in one or more liquid solutions, the liquid solution is an aqueous solution, with a sterile aqueous solution being particularly preferred. However, the components of the kit may be provided as dried powder(s). When reagents or components are provided as a dry powder, the powder can be reconstituted by the addition of a suitable solvent. It is envisioned that the solvent also may be provided in another container means. The container means of the kit will generally include at least one vial, test tube, flask, bottle, syringe or other container means, into which the active compound, and any other desired agent, may be placed and, preferably, suitably aliquoted. Where additional components are included, the kit will also generally contain a second vial or other container into which these are placed, enabling the administration of separated designed doses. The kits also may comprise a second/third container means for containing a sterile, pharmaceutically acceptable buffer or other diluent.
  • The kits also may contain a means by which to administer the compositions to an animal or patient, e.g., one or more needles or syringes, or even an eye dropper, pipette, or other such like apparatus, from which the formulation may be injected into the animal or applied to a afflicted area of the body. The kits of the present invention will also typically include a means for containing the vials, or such like, and other component, in close confinement for commercial sale, such as, e.g., injection or blow-molded plastic containers into which the desired vials and other apparatus are placed and retained.
  • The invention also provides compositions formulated for agricultural use. Examples of such formulations include herbicidal, fungicidal and plant growth regulator compositions. Specific formulations for plant application are known to those of skill in the art and are described, for example, in U.S. Pat. No. 6,242,382, the disclosure of which is specifically incorporated herein by reference in its entirety.
  • Examples of ingredients that may be included in a composition of the invention formulated for application to plants include surfactants, solid or liquid carriers, solvents and binders. Examples of suitable surfactants that may be used for application to plants include the alkali metal, alkaline earth metal or ammonium salts of aromatic sulfonic acids, e.g., ligno-, phenol-, naphthalene- and dibutylnaphthalenesulfonic acid, and of fatty acids of arylsulfonates, of alkyl ethers, of lauryl ethers, of fatty alcohol sulfates and of fatty alcohol glycol ether sulfates, condensates of sulfonated naphthalene and its derivatives with formaldehyde, condensates of naphthalene or of the naphthalenesulfonic acids with phenol and formaldehyde, condensates of phenol or phenolsulfonic acid with formaldehyde, condensates of phenol with formaldehyde and sodium sulfite, polyoxyethylene octylphenyl ether, ethoxylated isooctyl-, octyl- or nonylphenol, tributylphenyl polyglycol ether, alkylaryl polyether alcohols, isotridecyl alcohol, ethoxylated castor oil, ethoxylated triarylphenols, salts of phosphated triarylphenolethoxylates, lauryl alcohol polyglycol ether acetate, sorbitol esters, lignin-sulfite waste liquors or methylcellulose, or mixtures of these. Common practice in the case of surfactant use is to include about 0.5 to 25% by weight, based on the total weight of the solid mixture.
  • Compositions for application to plants may be solid or liquid. Where solid compositions are used, it may be desired to include one or more carrier materials with the active compound. Examples of carriers include mineral earths such as silicas, silica gels, silicates, talc, kaolin, attaclay, limestone, chalk, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, thiourea and urea, products of vegetable origin such as cereal meals, tree bark meal, wood meal and nutshell meal, cellulose powders, attapulgites, montmorillonites, mica, vermiculites, synthetic silicas and synthetic calcium silicates, or mixtures of these.
  • For liquid solutions, water-soluble compounds or salts may be included, such as sodium sulfate, potassium sulfate, sodium chloride, potassium chloride, sodium acetate, ammonium hydrogen sulfate, ammonium chloride, ammonium acetate, ammonium formate, ammonium oxalate, ammonium carbonate, ammonium hydrogen carbonate, ammonium thiosulfate, ammonium hydrogen diphosphate, ammonium dihydrogen monophosphate, ammonium sodium hydrogen phosphate, ammonium thiocyanate, ammonium sulfamate or ammonium carbamate.
  • Other exemplary components in compositions of the invention include binders such as polyvinylpyrrolidone, polyvinyl alcohol, partially hydrolyzed polyvinyl acetate, carboxymethylcellulose, starch, vinylpyrrolidone/vinyl acetate copolymers and polyvinyl acetate, or mixtures of these; lubricants such as magnesium stearate, sodium stearate, talc or polyethylene glycol, or mixtures of these; antifoams such as silicone emulsions, long-chain alcohols, phosphoric esters, acetylene diols, fatty acids or organofluorine compounds, and complexing agents such as: salts of ethylenediaminetetraacetic acid (EDTA), salts of trinitrilotriacetic acid or salts of polyphosphoric acids, or mixtures of these.
  • In certain embodiments of the invention, compositions are provided with herbicidal activity which comprise one or more ectophosphatase inhibitor(s) and a herbicide selected from the group consisting of pendimethalin, dicamba, 2,4-D, glufosinate, bentazon, trifluralin, oryzalin, S-metolachlor, nicosulfuron, MSMA, Epic™ and Balance™. In one embodiment of the invention, the ectophosphatase inhibitor is selected from the group of the compounds of formulae I-XX. In certain other embodiments of the invention, compositions with fungicidal activity are provided which comprise one or more ectophosphatase inhibitor(s) in combination with metalaxyl, tebuconazole, propiconazole, chlorothalonil and/or fluconazole.
  • Non-limiting examples of combinations of cytotoxic agents and ectophosphatase inhibitors for use in accordance with the invention include: fluconazole with compound(s) of formula II, IX, XIV, XVI, XV, X and/or XII; formula I and/or II with pendimethalin, dicamba, 2,4-D, bentazon, trifluralin, flufenacet/isoxaflutole or isoxaflutole; glufosinate with formula II; oryzalin with formula I; nicosulflron with formula II; MSMA with formula XVIII; S-metolachlor with formula VI and/or X; metribuzin with formula I, II and/or X; diuron with formula VI; metalaxyl with formula X; chlorothalonil with formula II, X, IX, XI, XVI; propiconazole with formula I, X, XIV and/or XVI; mancozeb with formula I, VI and/or X; captan with formula XIV and/or XVI; tebuconazole with formula I and/or X; imidacloprid with formula II, X, XVIII, XVI and/or XV; and fertilizers such as Nitrogen, Phosphate, Potash—12:12:12 with formula I and/or II.
  • Also envisioned for use with the invention are compositions comprising combinations of ectophosphatase inhibitors and cytotoxic agents or other active ingredients, including a herbicide, insecticide, antibiotic, fungicide, plant growth regulator and/or hormone. Such combinations may provide enhanced activity of the active ingredient relative to the use of a single ectophosphatase inhibitor. Non-limiting examples of such combinations of ectophosphatase inhibitors include combinations of two, three, four or more ectophosphatase inhibitors selected from formulas I, II, VI, X, XV, XIV, XVI, XVI, XV, and XVIII. Included for illustrative purposes are the following combinations: I and II; I, II and X; XIV and XVI; XVIII and XVI; XVI, XVI and XV; VI and X; II and X; and I and XVIII.
  • Specifically contemplated by the inventors are compositions comprising an ectophosphatase inhibitor and an active ingredient set forth in Table 1.
    TABLE 1
    Cytotoxic agents and other active ingredients
    U.S. EPA PC CA Chem
    Chemical Name CAS Number Code Code Use Type Chemical Class
    Bis(2-ethylhexyl) phthalate 117-81-7 3E+05 NA 11 N/A Alkyl Phthalate
    Butyl benzyl phthalate 85-68-7 NA 141 3080 N/A Alkyl Phthalate
    Chlorthal-dimethyl 1861-32-1 78701 179 Herbicide Alkyl Phthalate
    Di-n-octyl phthalate 117-84-0 NA 303 223 N/A Alkyl Phthalate
    Dibutyl phthalate 84-74-2 28001 199 Insect Alkyl Phthalate
    Repellent
    Diethyl phthalate 84-66-2 1E+05 3326 N/A Alkyl Phthalate
    Diisodecyl phthalate NA 1037 NA 132 2513 N/A Alkyl Phthalate
    Dimethyl phthalate 131-11-3 28002 232 Insect Alkyl Phthalate
    Repellent
    Dioctyl terephthalate NA 724 NA 133 2528 N/A Alkyl Phthalate
    Diphenyl phthalate 84-62-8 17001 NA 147 N/A Alkyl Phthalate
    Isooctyl phthalate 27554-26-3 NA 483 2262 N/A Alkyl Phthalate
    n-Butyl phthalate 84-74-2 28001 3081 Insecticide Alkyl Phthalate
    Poly glyceryl phthalate ester of NA 327 NA 608 3331 Adjuvant, Alkyl Phthalate
    coconut oil fatty acid Soap/Surfactant
    1,3-Dimethyl-1,1,3,3- 22232-20-8 34601 NA 303 N/A Bis-Carbamate
    disiloxanetetrol-1,3-
    bis(dimethylthiocarbamate)
    2,3(and 3,4)-Dichlorobenzyl 62046-37-1 3E+05 NA 136 Insecticide N-Methyl Carbamate
    methylcarbamates
    2,4-Dimethyl-1,3-dithiolane-2- 26419-73-8 4E+05 NA 143 Insecticide N-Methyl Carbamate
    carboxaldehyde O-
    (methylcarbamoyl)oxime
    2-(4,5-Dimethyl-1,3-dioxolan- ######## 4E+05 NA 145 Insecticide N-Methyl Carbamate
    2-yl)phenyl-N-
    methylcarbamate
    2-chloro-4,5-xylyl N-hydroxy- 14357-82-5 2E+05 NA 117 Insecticide N-Methyl Carbamate
    N-methylcarbamate
    2-cyclopentylphenyl 3282-00-6 3E+05 NA 132 Insecticide N-Methyl Carbamate
    methylcarbamate
    2-Hydroxyphenyl 10309-97-4 2E+05 NA 118 Insecticide N-Methyl Carbamate
    methylcarbamate
    3,4-Dichlorobenzyl 2328-31-6 3E+05 NA 136 Insecticide N-Methyl Carbamate
    methylcarbamate
    3,5-Diisopropylphenyl 330-64-3 4E+05 NA 142 Insecticide N-Methyl Carbamate
    methylcarbamate
    3-hydroxycarbofuran 16655-82-6 2E+05 4074 Breakdown N-Methyl Carbamate
    product
    3-iodo-2-propynyl butyl 55406-53-6 1E+05 1938 Fungicide, Other Carbamate
    carbamate Wood
    Preservative
    3-ketocarbofuran 16709-30-1 NA 176 NA 164 Breakdown N-Methyl Carbamate
    product
    4- 17702-57-7 4E+05 NA 142 Insecticide N-Methyl Carbamate
    (((Dimethylamino)methylene)amino)-
    m-tolyl
    methylcarbamate
    4-(Methylamino)-3,5-xylyl 10389-50-1 2E+05 NA 118 Insecticide N-Methyl Carbamate
    methylcarbamate
    4-(Methylformamido)-3,5- 10233-94-0 2E+05 NA 118 Insecticide N-Methyl Carbamate
    xylyl methylcarbamate
    4-(Methylthio)-m-tolyl 3566-00-5 6E+05 NA 157 Insecticide N-Methyl Carbamate
    methylcarbamate
    4-Amino-3,5-xylyl 831-76-5 2E+05 NA 117 Insecticide N-Methyl Carbamate
    methylcarbamate
    5,6,7,8-Tetrahydro-1-naphthyl 1136-84-1 4E+05 NA 148 Insecticide N-Methyl Carbamate
    methylcarbamate
    6-(and 2)-chloro-3,4-xylyl 8063-85-2 38701 NA 322 Insecticide N-Methyl Carbamate
    methylcarbamate
    6-Methyl-2-propyl-4- 2532-49-2 6E+05 NA 157 N/A Other Carbamate
    pyrimidinyl dimethylcarbamate
    Alanycarb 83130-01-2 NA 175 NA 47 Insecticide Other Carbamate
    Aldicarb 116-06-3 98301 575 Insecticide, N-Methyl Carbamate
    Nematicide
    Aldicarb sulfoxide 1646-87-3 1E+05 2361 Breakdown N-Methyl Carbamate
    product
    Aldoxycarb 1646-88-4 1E+05 2265 Breakdown N-Methyl Carbamate
    product
    Allyxycarb 6392-46-7 3E+05 NA 133 Insecticide N-Methyl Carbamate
    Aminocarb 2032-59-9 44401 2435 Insecticide N-Methyl Carbamate
    Asulam 3337-71-1 1E+05 5076 Herbicide Other Carbamate
    Asulam, sodium salt 2302-17-2 1E+05 1746 Herbicide Other Carbamate
    Bendiocarb 22781-23-3 1E+05 1924 Insecticide N-Methyl Carbamate
    Benfuracarb 82560-54-1 1E+05 NA 48 Insecticide Other Carbamate
    Bufencarb 2282-34-0 59302 91 Insecticide N-Methyl Carbamate
    Bufencarb 8065-36-9 59303 NA 485 Insecticide N-Methyl Carbamate
    Bufencarb, component of (with 672-04-8 59301 NA 484 Insecticide N-Methyl Carbamate
    059302)
    Butacarb 2655-19-8 3E+05 NA 135 Insecticide N-Methyl Carbamate
    Butocarboxim 34681-10-2 NA 175 NA 49 Insecticide N-Methyl Carbamate
    Butoxycarboxim 34681-23-7 1E+05 2201 Insecticide N-Methyl Carbamate
    Butylate 2008-41-5 41405 565 Herbicide Thiocarbamate
    Calcium 5895-18-1 14501 NA 139 Microbiocide Dithiocarbamate
    ethylenebis(dithiocarbamate)
    Carbanolate 671-04-5 2E+05 NA 124 Insecticide N-Methyl Carbamate
    Carbaryl 63-25-2 56801 105 Insecticide, N-Methyl Carbamate
    Plant Growth
    Regulator,
    Nematicide
    Carbofuran 1563-66-2 90601 106 Insecticide, N-Methyl Carbamate
    Nematicide
    Carbosulfan 55285-14-8 90602 2182 Insecticide N-Methyl Carbamate
    Chlorbufam 1967-16-4 6E+05 NA 157 Herbicide Other Carbamate
    Chlorprocarb 23121-99-53 3E+05 NA 136 Herbicide Other Carbamate
    Chlorpropham 101-21-3 18301 141 Herbicide, Other Carbamate
    Plant Growth
    Regulator
    Cloethocarb 51487-69-5 1E+05 NA 100 Insecticide, N-Methyl Carbamate
    Molluscicide
    Cufraneb 11096-18-7 NA 181 NA 180 Fungicide Dithiocarbamate
    Cycloate 1134-23-2 41301 516 Herbicide Thiocarbamate
    Desmedipham 13684-56-5 1E+05 1748 Herbicide Bis-Carbamate
    Diammonium ######## 14502 NA 140 Microbiocide Dithiocarbamate
    ethylenebis(dithiocarbamate)
    Dichlormate 1966-58-1 3E+05 690 Herbicide N-Methyl Carbamate
    Diethofencarb 87130-20-9 NA 184 NA 183 Fungicide Other Carbamate
    Dimepiperate 61432-55-1 NA 186 NA 185 Herbicide Thiocarbamate
    Dimetan 122-15-6 1E+05 NA 112 Insecticide Other Carbamate
    Dimethyl (4-methyl-1,3- 51543-98-7 1E+05 NA 888 Fungicide Bis-Carbamate
    phenylenebis(iminocarbonyl-
    1H-benzimidazole-1,2-
    diyl))biscarbamate
    Dimetilan 644-64-4 90101 NA 844 Insecticide Other Carbamate
    Dioxacarb 6988-21-2 4E+05 4067 Insecticide N-Methyl Carbamate
    EPTC 759-94-4 41401 264 Herbicide Thiocarbamate
    Esprocarb 85785-20-2 NA 203 NA 202 Herbicide Thiocarbamate
    Ethiofencarb 29973-13-5 1E+05 NA 50 Insecticide N-Methyl Carbamate
    Ethiolate 2941-55-1 1E+05 1793 Herbicide Thiocarbamate
    Fenethacarb 30087-47-9 3E+05 NA 141 Insecticide N-Methyl Carbamate
    Fenobucarb 3766-81-2 NA 176 NA 51 Insecticide N-Methyl Carbamate
    Fenothiocarb 62850-32-2 NA 188 NA 187 Insecticide Thiocarbamate
    Fenoxycarb 79127-80-3 1E+05 2283 Insecticide, Other Carbamate
    Insect Growth
    Regulator
    Fenoxycarb 72490-01-8 NA 228 NA 228 Insecticide, Other Carbamate
    Insect Growth
    Regulator
    Ferbam 14484-64-1 34801 288 Fungicide Dithiocarbamate
    Ferric nitroso dimethyl 83542-83-0 5E+05 NA 149 Microbiocide Dithiocarbamate
    dithiocarbamate
    Formetanate 22259-30-9 5E+05 NA 150 Insecticide N-Methyl Carbamate
    Formetanate hydrochloride 23422-53-9 97301 111 Insecticide N-Methyl Carbamate
    Furathiocarb 65907-30-4 NA 176 NA 52 Insecticide Thiocarbamate
    Isolan 119-38-0 5E+05 NA 155 Insecticide Other Carbamate
    Isopolinate 3134-70-1 NA 232 NA 232 Herbicide Thiocarbamate
    Isoprocarb 2631-40-5 5E+05 NA 53 Insecticide N-Methyl Carbamate
    Karbutilate 4849-32-5 97401 691 Herbicide Other Carbamate
    m-Cumenyl methylcarbamate 64-00-6 47801 NA 414 Insecticide N-Methyl Carbamate
    Mancopper 53988-93-5 NA 181 NA 180 Fungicide Dithiocarbamate
    Mancozeb ######## 14504 211 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Maneb 12427-38-2 14505 369 Fungicide Dithiocarbamate
    Maneb and nickel sulfate 8005-46-7 6E+05 NA 158 Fungicide Dithiocarbamate,
    hexahydrate (014505 + 050505) Inorganic-Nickel
    Manganous 15339-36-3 34802 NA 304 Fungicide Dithiocarbamate
    dimethyldithiocarbamate
    Mecarbinizid 27386-64-7 6E+05 NA 157 N/A Other Carbamate
    Mercuric dimethyl 15415-64-2 34808 709 Microbiocide Inorganic-Mercury,
    dithiocarbamate Heavy metal,
    Dithiocarbamate
    Metam sodium, dihydrate 137-42-8 39003 NA 163 Fumigant, Dithiocarbamate
    Fungicide,
    Microbiocide,
    Algaecide,
    Nematicide
    Metam-sodium 6734-80-1 39003 616 Fumigant, Dithiocarbamate
    Herbicide,
    Fungicide,
    Microbiocide,
    Algaecide,
    Nematicide
    Methasulfocarb 66952-49-6 NA 202 NA 201 Fungicide, Thiocarbamate
    Plant Growth
    Regulator
    Methiobencarb 18357-78-3 NA 232 NA 232 Herbicide Thiocarbamate
    Methiocarb 2032-65-7 1E+05 375 Insecticide, N-Methyl Carbamate
    Molluscicide
    Methiocarb sulfone 2179-25-1 2E+05 4077 Breakdown N-Methyl Carbamate
    product
    Methiocarb sulfoxide ######## 2E+05 4078 Breakdown N-Methyl Carbamate
    product
    Methomyl 16752-77-5 90301 383 Insecticide, N-Methyl Carbamate
    Breakdown
    product
    Metiram 9006-42-2 14601 493 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Metolcarb 1129-41-5 NA 202 NA 201 Insecticide N-Methyl Carbamate
    Mexacarbate 315-18-4 44201 623 Insecticide N-Methyl Carbamate
    Mobam 1079-33-0 90401 NA 848 Insecticide N-Methyl Carbamate
    Molinate 2212-67-1 41402 449 Herbicide Thiocarbamate
    Molinate sulfoxide NA 1052 NA 156 4080 Breakdown Thiocarbamate
    product
    Morpholinomethyl 31848-11-0 6E+05 NA 158 Microbiocide Dithiocarbamate
    dimethyldithiocarbamate
    Nabam 142-59-6 14503 417 Fungicide, Dithiocarbamate
    Herbicide
    Nitrilacarb 29672-19-3 2E+05 NA 129 Insecticide Other Carbamate
    o-(2-Propynyloxy)phenyl 3279-46-7 3E+05 NA 138 Insecticide N-Methyl Carbamate
    methylcarbamate
    Orbencarb 34622-58-7 NA 189 NA 188 Herbicide Thiocarbamate
    Oxamyl 23135-22-0 1E+05 1910 Insecticide, N-Methyl Carbamate
    Nematicide
    Pebulate 1114-71-2 41403 590 Herbicide Thiocarbamate
    Phenisopham 57375-63-0 NA 209 NA 208 Herbicide Bis-Carbamate
    Phenmedipham 13684-63-4 98701 675 Herbicide Bis-Carbamate
    Phenmedipham-ethyl 13684-44-1 4E+05 NA 149 Herbicide Bis-Carbamate
    Phenylmercuric 32407-99-1 66008 NA 555 Microbiocide, Organomercury,
    dimethyldithiocarbamate Fungicide Dithiocarbamate,
    Heavy metal
    Pirimicarb 23103-98-2 1E+05 1875 Insecticide N-Methyl Carbamate
    Pirimicarb sulfone NA 1050 NA 155 4090 Breakdown N-Methyl Carbamate
    product
    Pirimicarb sulfoxide NA 1049 NA 155 4091 Breakdown N-Methyl Carbamate
    product
    Potassium ammonium 22221-14-3 14507 NA 141 Microbiocide Dithiocarbamate
    ethylenebis(dithiocarbamate)
    Potassium asulam 14089-43-1 1E+05 NA 893 Herbicide Other Carbamate
    Potassium dimethyl dithio 128-03-0 34803 1934 Microbiocide Dithiocarbamate
    carbamate
    Potassium N-hydroxymethyl- 51026-28-9 1E+05 1824 N/A Dithiocarbamate
    N-methyldithio carbamate
    Potassium N-methyldithio 137-41-7 39002 970 Fumigant, Dithiocarbamate
    carbamate Fungicide,
    Microbiocide,
    Algaecide,
    Nematicide
    Promacyl 34264-24-9 NA 209 NA 209 Insecticide N-Methyl Carbamate
    Promecarb 2631-37-0 3E+05 4092 Insecticide N-Methyl Carbamate
    Propamocarb 24579-73-5 1E+05 2147 Fungicide Other Carbamate
    Propamocarb hydrochloride 25606-41-1 1E+05 4022 Fungicide Other Carbamate
    Propham 122-42-9 47601 339 Herbicide, Other Carbamate
    Plant Growth
    Regulator
    Propineb 12071-83-9 5E+05 NA 155 Fungicide, Dithiocarbamate,
    Microbiocide Inorganic-Zinc
    Propoxur 114-26-1 47802 62 Insecticide N-Methyl Carbamate
    Propoxur, other related NA 1073 NA 161 90062 Insecticide N-Methyl Carbamate
    Prosulfocarb 52888-80-9 NA 185 NA 184 Herbicide Thiocarbamate
    Prothiocarb 19622-08-3 NA 183 NA 182 Fungicide Thiocarbamate
    Prothiocarb hydrochloride 19622-19-6 NA 200 NA 199 Fungicide Thiocarbamate
    Pyributicarb 88678-67-5 NA 229 NA 229 Herbicide Thiocarbamate
    Pyrolan 87-47-8 6E+05 NA 157 Insecticide Other Carbamate
    S-tert-Butyl 2212-63-7 2E+05 NA 128 Herbicide Thiocarbamate
    dipropylthiocarbamate
    Sodium dimethyl dithio 128-04-1 34804 548 Fungicide Dithiocarbamate
    carbamate
    Sulfallate 95-06-7 39001 115 Herbicide Dithiocarbamate
    Swep 1918-18-9 84601 4098 N/A Other Carbamate
    Terbutol ######## 38801 51 Herbicide N-Methyl Carbamate
    Tert-butyl dimethyl trithio 3304-97-0 34807 1383 Rodent Dithiocarbamate
    peroxycarbamate Repellent
    Tert- NA 1130 NA 166 91383 N/A Dithiocarbamate
    butyldimethyltrithioperoxycarbamate,
    other related
    Thiobencarb 28249-77-6 1E+05 1933 Herbicide Thiocarbamate
    Thiobencarb sulfoxide NA 1042 NA 139 2937 Breakdown Thiocarbamate
    product
    Thiocarboxime 25171-63-5 6E+05 NA 156 N/A N-Methyl Carbamate
    Thiodicarb 59669-26-0 1E+05 2202 Molluscicide, Thiocarbamate
    Insecticide
    Thiofanox 39196-18-4 1E+05 2938 Insecticide N-Methyl Carbamate
    Thiram 137-26-8 79801 589 Fungicide Dithiocarbamate
    Thiram and NAD and IBA and 75497-92-6 56011 NA 463 Fungicide, Dithiocarbamate
    2-methyl-1- Plant Growth
    naphthaleneacetamide and 2- Regulator
    methyl-1-naphthaleneacetic
    acid
    Tiocarbazil 36756-79-3 1E+05 NA 911 Herbicide Thiocarbamate
    Triallate 2303-17-5 78802 49 Herbicide Thiocarbamate
    Tricopper dichloride 7076-63-3 5E+05 NA 152 Microbiocide Dithiocarbamate,
    dimethyldithiocarbamate Inorganic-Copper
    Trimethacarb 12407-86-2 1E+05 2962 Insecticide, N-Methyl Carbamate
    Molluscicide,
    Dog and Cat
    Repellent
    Trimethacarb, (2,3,5)- 2655-15-4 1E+05 NA 882 Insecticide, N-Methyl Carbamate
    component of Molluscicide
    Trimethacarb, (3,4,5)- 2686-99-9 1E+05 NA 881 Insecticide, N-Methyl Carbamate
    component of Molluscicide
    Vernolate 1929-77-7 41404 1987 Herbicide Thiocarbamate
    XMC 2655-14-3 NA 176 NA 54 Insecticide N-Methyl Carbamate
    Xylylcarb ######## NA 176 NA 55 Insecticide N-Methyl Carbamate
    Zineb 12122-67-7 14506 627 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Zineb-ethylene thiuram NA 1465 NA 217 NA 216 Fungicide Dithiocarbamate,
    disulfide adduct Inorganic-Zinc
    Ziram 137-30-4 34805 629 Fungicide, Dithiocarbamate,
    Microbiocide, Inorganic-Zinc
    Dog and Cat
    Repellent
    Ziram, cyclohexylamine 16509-79-8 34806 1328 Dog and Cat Dithiocarbamate,
    complex Repellent, Inorganic-Zinc
    Fungicide
    Acetamiprid 135410-20-7 99050 NA 864 Insecticide Chloro-nicotinyl
    Imidacloprid 105827-78-9 ##### 3849 Insecticide Chloro-nicotinyl
    Imidacloprid 138261-41-3 ##### NA 111 Insecticide Chloro-nicotinyl
    Thiacloprid 111988-49-9 NA 201 NA 201 Insecticide Chloro-nicotinyl
    Halofenozide 112226-61-6 ##### 5019 Insecticide Diacylhydrazine
    Methoxyfenozide 161050-58-4 ##### NA 983 Insecticide Diacylhydrazine
    Tebufenozide 112410-23-8 ##### 3957 Insecticide Diacylhydrazine
    Bacillus thuringiensis Cry1F NA 1486 6481 NA 220 Insecticide GE Crop
    protein and the genetic material
    necessary for its production
    (plasmid insert PHI8999) in
    corn pla
    Bacillus thuringiensis Cry1Ab NA 1487 6430 NA 220 Insecticide GE Crop
    Delta-Endotoxin and the
    Genetic Material Necessary for
    Its Production in Corn [MON
    810]
    Bacillus thuringiensis delta 68038-71-1 NA 160 3954 Insecticide GE Crop
    endotoxin produced in corn
    Bacillus thuringiensis subsp. NA 1226 6463 NA 170 Insecticide GE Crop
    Kurstaki CryIA (c) delta-
    endotoxin and the genetic
    material necessary for its
    production in corn
    Bacillus thuringiensis subsp. 68038-71-1 6444 5048 Insecticide GE Crop
    Kurstaki, delta-endotoxin as
    produced in corn by an HD-1
    gene, and its controlling
    sequences and
    Bacillus thuringiensis subsp. NA 1233 6466 NA 171 Insecticide GE Crop
    Tolworthi Cry9C protein and
    the genetic material necessary
    for its production (pRVA9909)
    in corn p
    Bacillus thuringiensis NA 1237 6432 NA 171 Insecticide GE Crop
    subspecies Tenebrionis delta
    endotoxin as produced in
    potato by Cry IIIA gene and its
    controlling sequenc
    Bacillus thuringiensis var. NA 1480 6402 3554 Insecticide GE Crop
    Kurstaki protein in cottonseed
    Bacillus thuringiensis, subsp. 68038-71-1 6461 3986 Insecticide GE Crop
    Kurstaki, strain HD-1, delta-
    endotoxin as produced in corn
    by a Cry 1A(b) gene and its
    controlling
    HD-1 Protein as encoded by NA 1273 6408 NA 173 Insecticide GE Crop
    Bacillus thuringiensis subsp.
    kurstaki gene and produced in
    corn
    Plant pesticide Bacillus NA 1285 6458 NA 174 Insecticide GE Crop
    thuringiensis Cry1A(b) delta-
    endotoxin and the genetic
    material necessary for its
    production (plasmid V
    Potato leafroll virus (PLRV) NA 1295 6469 NA 175 Fungicide GE Crop
    replicase protein as produced in
    potato plants
    1,1,1-trichloroethane 71-55-6 81201 138 Solvent Halogenated organic
    1,1,2-trichloro-1,2,2-trifluoro- 76-13-1 NA 972 2960 Solvent Halogenated organic
    ethane
    1,1,2-trichloroethane 79-00-5 81203 1425 Solvent Halogenated organic
    1,2,3,4-Tetrachlorobenzene 634-66-2 61101 NA 494 N/A Halogenated organic
    1,2,4-trichlorobenzene 120-82-1 81101 600 N/A Halogenated organic
    1,2-dichloropropane 78-87-5 29002 2501 Fumigant, Halogenated organic
    Nematicide
    1,2-Dichloropropane mixt. with ######## 29004 NA 215 Fumigant, Halogenated organic
    1,3-dichloropropene and Nematicide
    methyl isothiocyanate
    1,2-dichloropropane, 1,3- NA 1022 29002 185 Fumigant, Halogenated organic
    dichloropropene and related C3 Nematicide
    compounds
    1,3-Dichloro-1-propene, mixt. 8003-19-8 29003 NA 214 Fumigant, Halogenated organic
    with 1,2-dichloropropane Nematicide
    1,3-dichloropropene 542-75-6 29001 573 Fumigant, Halogenated organic
    Nematicide
    1-chloro-1,1-difluoro ethane 75-68-3 NA 423 3103 Solvent Halogenated organic
    1-chlorobutane 109-69-3 NA 425 1151 Solvent Halogenated organic
    3-chloro-2-methyl propene 563-47-3 NA 422 2463 N/A Halogenated organic
    Bis(2,2-dichloroethyl)ether 1191-17-9 29502 NA 217 N/A Halogenated organic
    Bromoethane 74-96-4 NA 131 2427 N/A Halogenated organic
    Carbon tetrachloride 56-23-5 16501 109 Solvent, Halogenated organic
    Fumigant
    Carbon tetrachloride with EDB 53908-27-3 16503 NA 146 Fumigant, Halogenated organic
    & EDC Nematicide
    Carbon tetrachloride with EDC ######## 16502 NA 145 Fumigant, Halogenated organic
    Nematicide
    Carbon tetrafluoride 75-73-0 NA 113 3099 Propellant Halogenated organic
    Chloro difluoro methane 75-45-6 15 3104 Propellant, Halogenated organic
    Fumigant,
    Insecticide
    Chlorodibromomethane 124-48-1 NA 426 2462 N/A Halogenated organic
    Chloroform 67-66-3 20701 133 Solvent, Halogenated organic
    Fumigant
    DBCP 96-12-8 11301 183 Fumigant, Halogenated organic
    Nematicide
    DBCP, other related NA 1079 NA 161 90183 Fumigant, Halogenated organic
    Nematicide
    Dichloroethylene, 1,1- 75-35-4 6E+05 NA 13 Impurity Halogenated organic
    Dichlorofluoromethane 75-43-4 NA 348 1815 Propellant Halogenated organic
    Difluoro diphenyl 475-26-3 32001 NA 293 N/A Halogenated organic
    trichloroethane
    Ethane, 1,1,1,2-tetrafluoro- 811-97-2 1E+05 NA 873 N/A Halogenated organic
    Ethyl chloride 75-00-3 NA 114 3198 N/A Halogenated organic
    Ethylene chlorobromide 107-04-0 42001 2557 N/A Halogenated organic
    Ethylene dibromide 106-93-4 42002 271 Fumigant, Halogenated organic
    Nematicide
    Ethylene dichloride 107-06-2 42003 274 Fumigant, Halogenated organic
    Insecticide
    Freon 11 75-69-4 13 1460 Propellant, Halogenated organic
    Fumigant,
    Insecticide
    Freon 12 75-71-8 14 1459 Propellant, Halogenated organic
    Fumigant,
    Insecticide
    Halazone 80-13-7 77201 316 N/A Halogenated organic
    Hexachloroacetone 116-16-5 43701 320 Herbicide Halogenated organic
    Hexachloroacetone, other NA 1090 NA 162 90320 Herbicide Halogenated organic
    related
    Hexachloroethane 67-72-1 45201 NA 22 N/A Halogenated organic
    Hydrofluorocarbon 152A NA 617 NA 112 2599 Propellant Halogenated organic
    Methyl bromide 74-83-9 53201 385 Fumigant, Halogenated organic
    Insecticide,
    Herbicide,
    Nematicide
    Methyl chloride 74-87-3 53202 2677 N/A Halogenated organic
    Methyl iodide 74-88-4 NA 177 NA 165 Fumigant, Halogenated organic
    Nematicide
    Methylene chloride 75-09-2 42004 388 Solvent, Dog Halogenated organic
    and Cat
    Repellent
    Ortho-dichlorobenzene 95-50-1 59401 578 Insecticide Halogenated organic
    Ortho-dichlorobenzene, other NA 1116 NA 165 90683 Insecticide Halogenated organic
    related
    Para-dichlorobenzene 106-46-7 61501 455 Insecticide, Halogenated organic
    Insect
    Repellent,
    Rodenticide,
    Fungicide
    Pentachloroethane 76-01-7 6E+05 NA 159 N/A Halogenated organic
    Propargyl bromide 106-96-7 68701 NA 608 Fumigant, Halogenated organic
    Nematicide
    Tetrachloroethane 79-34-5 78601 3559 Solvent, Halogenated organic
    Fumigant
    Tetrachloroethylene 127-18-4 78501 1174 Solvent Halogenated organic
    Tetraiodo ethylene 513-92-8 46908 582 N/A Halogenated organic
    trans-1,3-Dichloropropene 10061-02-6 NA 227 NA 227 Fumigant Halogenated organic
    Trichloro ethylene 79-01-6 81202 595 N/A Halogenated organic
    Trichlorobenzene 87-61-6 NA 971 1619 N/A Halogenated organic
    Trichlorofluoromethane 75-69-4 13 3482 Propellant, Halogenated organic
    Fumigant,
    Insecticide
    Trichloromethane 67-66-3 20701 1758 Solvent, Halogenated organic
    Fumigant
    2,3(and 3,4)-Dichlorobenzyl 62046-37-1 ##### NA 136 Insecticide N-Methyl Carbamate
    methylcarbamates
    2,4-Dimethyl-1,3-dithiolane-2- 26419-73-8 ##### NA 143 Insecticide N-Methyl Carbamate
    carboxaldehyde O-
    (methylcarbamoyl)oxime
    2-(4,5-Dimethyl-1,3-dioxolan- 1905930 ##### NA 145 Insecticide N-Methyl Carbamate
    2-yl)phenyl-N-
    methylcarbamate
    2-chloro-4,5-xylyl N-hydroxy- 14357-82-5 ##### NA 117 Insecticide N-Methyl Carbamate
    N-methylcarbamate
    2-cyclopentylphenyl 3282-00-6 ##### NA 132 Insecticide N-Methyl Carbamate
    methylcarbamate
    2-Hydroxyphenyl 10309-97-4 ##### NA 118 Insecticide N-Methyl Carbamate
    methylcarbamate
    3,4-Dichlorobenzyl 2328-31-6 ##### NA 136 Insecticide N-Methyl Carbamate
    methylcarbamate
    3,5-Diisopropylphenyl 330-64-3 ##### NA 142 Insecticide N-Methyl Carbamate
    methylcarbamate
    3-hydroxycarbofuran 16655-82-6 ##### 4074 Breakdown N-Methyl Carbamate
    product
    3-ketocarbofuran 16709-30-1 NA 176 NA 164 Breakdown N-Methyl Carbamate
    product
    4- 17702-57-7 ##### NA 142 Insecticide N-Methyl Carbamate
    (((Dimethylamino)methylene)amino)-
    m-tolyl
    methylcarbamate
    4-(Methylamino)-3,5-xylyl 10389-50-1 ##### NA 118 Insecticide N-Methyl Carbamate
    methylcarbamate
    4-(Methylformamido)-3,5- 10233-94-0 ##### NA 118 Insecticide N-Methyl Carbamate
    xylyl methylcarbamate
    4-(Methylthio)-m-tolyl 3566-00-5 ##### NA 157 Insecticide N-Methyl Carbamate
    methylcarbamate
    4-Amino-3,5-xylyl 831-76-5 ##### NA 117 Insecticide N-Methyl Carbamate
    methylcarbamate
    5,6,7,8-Tetrahydro-1-naphthyl 1136-84-1 ##### NA 148 Insecticide N-Methyl Carbamate
    methylcarbamate
    6-(and 2)-chloro-3,4-xylyl 8063-85-2 38701 NA 322 Insecticide N-Methyl Carbamate
    methylcarbamate
    Aldicarb 116-06-3 98301 575 Insecticide, N-Methyl Carbamate
    Nematicide
    Aldicarb sulfoxide 1646-87-3 ##### 2361 Breakdown N-Methyl Carbamate
    product
    Aldoxycarb 1646-88-4 ##### 2265 Breakdown N-Methyl Carbamate
    product
    Allyxycarb 6392-46-7 ##### NA 133 Insecticide N-Methyl Carbamate
    Aminocarb 2032-59-9 44401 2435 Insecticide N-Methyl Carbamate
    Bendiocarb 22781-23-3 ##### 1924 Insecticide N-Methyl Carbamate
    Bufencarb 2282-34-0 59302 91 Insecticide N-Methyl Carbamate
    Bufencarb 8065-36-9 59303 NA 485 Insecticide N-Methyl Carbamate
    Bufencarb, component of (with 672-04-8 59301 NA 484 Insecticide N-Methyl Carbamate
    059302)
    Butacarb 2655-19-8 ##### NA 135 Insecticide N-Methyl Carbamate
    Butocarboxim 34681-10-2 NA 175 NA 49 Insecticide N-Methyl Carbamate
    Butoxycarboxim 34681-23-7 ##### 2201 Insecticide N-Methyl Carbamate
    Carbanolate 671-04-5 ##### NA 124 Insecticide N-Methyl Carbamate
    Carbaryl 63-25-2 56801 105 Insecticide, N-Methyl Carbamate
    Plant Growth
    Regulator,
    Nematicide
    Carbofuran 1563-66-2 90601 106 Insecticide, N-Methyl Carbamate
    Nematicide
    Carbosulfan 55285-14-8 90602 2182 Insecticide N-Methyl Carbamate
    Cloethocarb 51487-69-5 ##### NA 100 Insecticide, N-Methyl Carbamate
    Molluscicide
    Dichlormate 1966-58-1 ##### 690 Herbicide N-Methyl Carbamate
    Dioxacarb 6988-21-2 ##### 4067 Insecticide N-Methyl Carbamate
    Ethiofencarb 29973-13-5 ##### NA 50 Insecticide N-Methyl Carbamate
    Fenethacarb 30087-47-9 ##### NA 141 Insecticide N-Methyl Carbamate
    Fenobucarb 3766-81-2 NA 176 NA 51 Insecticide N-Methyl Carbamate
    Formetanate 22259-30-9 ##### NA 150 Insecticide N-Methyl Carbamate
    Formetanate hydrochloride 23422-53-9 97301 111 Insecticide N-Methyl Carbamate
    Isoprocarb 2631-40-5 ##### NA 53 Insecticide N-Methyl Carbamate
    m-Cumenyl methylcarbamate 64-00-6 47801 NA 414 Insecticide N-Methyl Carbamate
    Methiocarb 2032-65-7 ##### 375 Insecticide, N-Methyl Carbamate
    Molluscicide
    Methiocarb sulfone 2179-25-1 ##### 4077 Breakdown N-Methyl Carbamate
    product
    Methiocarb sulfoxide 267266 ##### 4078 Breakdown N-Methyl Carbamate
    product
    Methomyl 16752-77-5 90301 383 Insecticide, N-Methyl Carbamate
    Breakdown
    product
    Metolcarb 1129-41-5 NA 202 NA 201 Insecticide N-Methyl Carbamate
    Mexacarbate 315-18-4 44201 623 Insecticide N-Methyl Carbamate
    Mobam 1079-33-0 90401 NA 848 Insecticide N-Methyl Carbamate
    o-(2-Propynyloxy)phenyl 3279-46-7 ##### NA 138 Insecticide N-Methyl Carbamate
    methylcarbamate
    Oxamyl 23135-22-0 ##### 1910 Insecticide, N-Methyl Carbamate
    Nematicide
    Pirimicarb 23103-98-2 ##### 1875 Insecticide N-Methyl Carbamate
    Pirimicarb sulfone NA 1050 NA 155 4090 Breakdown N-Methyl Carbamate
    product
    Pirimicarb sulfoxide NA 1049 NA 155 4091 Breakdown N-Methyl Carbamate
    product
    Promacyl 34264-24-9 NA 209 NA 209 Insecticide N-Methyl Carbamate
    Promecarb 2631-37-0 ##### 4092 Insecticide N-Methyl Carbamate
    Propoxur 114-26-1 47802 62 Insecticide N-Methyl Carbamate
    Propoxur, other related NA 1073 NA 161 90062 Insecticide N-Methyl Carbamate
    Terbutol 5419 38801 51 Herbicide N-Methyl Carbamate
    Thiocarboxime 25171-63-5 ##### NA 156 N/A N-Methyl Carbamate
    Thiofanox 39196-18-4 ##### 2938 Insecticide N-Methyl Carbamate
    Trimethacarb 12407-86-2 ##### 2962 Insecticide, N-Methyl Carbamate
    Molluscicide,
    Dog and Cat
    Repellent
    Trimethacarb, (2,3,5)- 2655-15-4 ##### NA 882 Insecticide, N-Methyl Carbamate
    component of Molluscicide
    Trimethacarb, (3,4,5)- 2686-99-9 ##### NA 881 Insecticide, N-Methyl Carbamate
    component of Molluscicide
    XMC 2655-14-3 NA 176 NA 54 Insecticide N-Methyl Carbamate
    Xylylcarb 190572 NA 176 NA 55 Insecticide N-Methyl Carbamate
    Aldrin 309-00-2 45101 9 Insecticide Organochlorine
    Aldrin, other related NA 1069 NA 160 90009 Insecticide Organochlorine
    alpha-BHC 319-84-6 NA 200 767 Insecticide Organochlorine
    Arochlor (composition 12767-79-2 17803 NA 161 N/A Organochlorine
    unspecified, PCBs and/or
    PCTs)
    Aroclor 1336-36-3 17801 5003 N/A Organochlorine
    Bandane 8029-29-6 20301 54 Insecticide Organochlorine
    BHC (other than gamma NA 1092 NA 162 90359 Insecticide Organochlorine
    isomer)
    BHC, beta isomer 319-85-7 NA 175 NA 46 Insecticide Organochlorine
    Chlordane 57-74-9 58201 130 Insecticide Organochlorine
    Chlordane, other related NA 1075 NA 161 90130 Insecticide Organochlorine
    Chlordane, technical 12789-03-6 58202 NA 477 Insecticide Organochlorine
    Chlordecone 143-50-0 27701 347 Insecticide Organochlorine
    Chlorendic Acid 115-28-6 NA 228 NA 228 N/A Organochlorine
    DDD 72-54-8 29101 3002 Insecticide Organochlorine
    DDD 6088-31-3 NA 415 184 Breakdown Organochlorine
    product
    DDD, other related NA 1080 NA 161 90184 Breakdown Organochlorine
    product
    DDE 72-55-9 NA 129 2092 Breakdown Organochlorine
    product
    DDT 50-29-3 29201 186 Insecticide Organochlorine
    Dicofol 115-32-2 10501 346 Insecticide Organochlorine
    Dieldrin 60-57-1 45001 210 Insecticide, Organochlorine
    Breakdown
    product
    Dieldrin, other related NA 1085 NA 162 90210 Insecticide Organochlorine
    Dienochlor 2227-17-0 27501 468 Insecticide Organochlorine
    Dioxin (2,3,7,8-TCDD) 1746-01-6 ##### 4068 Impurity Organochlorine
    Dioxin (other than 2,3,7,8- NA 1319 NA 177 NA 176 Impurity Organochlorine
    TCDD)
    Endosulfan 115-29-7 79401 259 Insecticide Organochlorine
    Endosulfan I (alpha) 959-98-8 79402 NA 771 Insecticide Organochlorine
    Endosulfan II (beta) 33213-65-9 79403 4046 Insecticide Organochlorine
    Endosulfan sulfate 1031-07-8 79404 4047 Breakdown Organochlorine
    product
    Endrin 72-20-8 41601 262 Insecticide, Organochlorine
    Avicide
    Endrin aldehyde 7421-93-4 NA 156 4069 Breakdown Organochlorine
    product
    Endrin ketone 53494-70-5 41601 5029 Breakdown Organochlorine
    product
    Endrin, other related NA 1086 NA 162 90262 Insecticide Organochlorine
    Heptachlor 76-44-8 44801 317 Insecticide Organochlorine
    Heptachlor epoxide 1024-57-3 44801 4073 Breakdown Organochlorine
    product
    Heptachlor, other related NA 1089 NA 162 90317 Insecticide Organochlorine
    Hexachloro dibenzo-p-dioxin 34465-46-8 ##### 2587 Impurity Organochlorine
    Hexachlorobenzene 118-74-1 61001 321 Microbiocide, Organochlorine
    Fungicide,
    Insecticide
    Hexachlorocyclohexane 608-73-1 8901 NA 20 Insecticide Organochlorine
    Hexachlorocyclopentadiene 77-47-4 27502 NA 21 Insecticide Organochlorine
    Hexachlorodibenzofuran (as 55684-94-1 ##### NA 161 Impurity Organochlorine
    impurity)
    Isodrin 465-73-6 NA 208 NA 207 Insecticide Organochlorine
    Kelevan 4234-79-1 NA 208 NA 208 Insecticide Organochlorine
    Lindane 58-89-9 9001 359 Insecticide, Organochlorine
    Rodenticide
    Methoxychlor 72-43-5 34001 384 Insecticide Organochlorine
    Methoxychlor, other related NA 1093 NA 162 90384 Insecticide Organochlorine
    Mirex 2385-85-5 39201 402 Insecticide Organochlorine
    Nonachlor 3734-49-4 44802 5448 Insecticide Organochlorine
    Oxychlordane 27304-13-8 NA 177 NA 177 Breakdown Organochlorine
    product
    Oxychlordane, mix of isomers 26880-48-8 NA 177 NA 177 Breakdown Organochlorine
    product
    Strobane 8001-50-1 20401 553 Insecticide Organochlorine
    Toxaphene 8001-35-2 80501 594 Insecticide Organochlorine
    trans-Nonachlor 39765-80-5 NA 177 NA 177 Insecticide Organochlorine
    (E)-Mevinphos 298-01-1 15802 NA 143 Insecticide Organophosphorus
    (Z)-Mevinphos 338-45-4 15803 NA 144 Insecticide Organophosphorus
    2,5-dichloro-alpha- 2701-86-2 ##### NA 116 Insecticide Organophosphorus
    (chloromethylene)benzyl
    diethyl phosphate
    2,5-dichloro-alpha- 5723-62-6 ##### NA 116 Insecticide Organophosphorus
    (dichloromethylene)benzyl
    diethyl phosphate
    Acephate 30560-19-1 ##### 1685 Insecticide Organophosphorus
    Acethion 919-54-0 ##### NA 139 Insecticide Organophosphorus
    Acetoxon 2425-25-4 ##### NA 139 Insecticide, Organophosphorus
    Breakdown
    product
    Akton 1757-18-2 84901 1421 Insecticide Organophosphorus
    Akton, other related NA 1131 NA 166 91421 Insecticide Organophosphorus
    alpha,alpha-Dithiol bis(O,O- 2782-70-9 ##### NA 150 N/A Organophosphorus
    dimethyl
    phosphorodithioate)toluene
    Amidithion 919-76-6 59601 NA 487 Insecticide Organophosphorus
    Amiton 78-53-5 57302 NA 473 Insecticide Organophosphorus
    Amiton oxalate 3734-97-2 57301 NA 472 Insecticide Organophosphorus
    Anilofos 64249-01-0 NA 202 NA 201 Insecticide Organophosphorus
    Athidathion 19691-80-6 ##### NA 141 Insecticide Organophosphorus
    Azamethiphos 35575-96-3 ##### NA 111 Insecticide Organophosphorus
    Azethion 72348-92-6 ##### NA 139 Insecticide Organophosphorus
    Azinphos-ethyl 2642-71-9 58002 4053 Insecticide Organophosphorus
    Azinphos-methyl 86-50-0 58001 314 Insecticide Organophosphorus
    Azinphos-methyl oxygen NA 1057 NA 157 4054 Breakdown Organophosphorus
    analog product
    Azothoate 5834-96-8 ##### NA 118 Insecticide Organophosphorus
    Bensulide 741-58-2 9801 70 Herbicide Organophosphorus
    Bomyl 122-10-1 84201 77 Insecticide Organophosphorus
    Bromophos 2104-96-3 8706 NA 106 Insecticide Organophosphorus
    Bromophos-ethyl 4824-78-6 ##### NA 122 Insecticide Organophosphorus
    Butamifos 36335-67-8 NA 202 NA 201 Herbicide Organophosphorus
    Butathiofos 90338-20-8 ##### 2433 Insecticide Organophosphorus
    Butonate 126-22-7 35701 255 N/A Organophosphorus
    Cadusafos 95465-99-9 ##### NA 14 Insecticide Organophosphorus
    Carbophenothion 786-19-6 58102 110 Insecticide Organophosphorus
    Chlorethoxyphos 54593-83-8 ##### 5106 Insecticide Organophosphorus
    Chlorfenvinphos 470-90-6 84101 306 Insecticide Organophosphorus
    Chlormephos 24934-91-6 ##### NA 136 Insecticide Organophosphorus
    Chlorphoxim 14816-20-7 NA 207 NA 206 Insecticide Organophosphorus
    Chlorprazophos 36145-08-1 ##### NA 136 Insecticide Organophosphorus
    Chlorpyrifos 2921-88-2 59101 253 Insecticide, Organophosphorus
    Nematicide
    Chlorpyrifos oxygen analog 5598-15-2 59101 5034 Insecticide, Organophosphorus
    Breakdown
    product
    Chlorpyrifos-methyl 5598-13-0 59102 2468 Insecticide Organophosphorus
    Chlorthion 500-28-7 34501 NA 300 Insecticide Organophosphorus
    Chlorthiophos 21923-23-9 ##### 2469 Insecticide Organophosphorus
    Chlorthiophos 60238-56-4 ##### NA 919 Insecticide Organophosphorus
    Chlorthiophos II 77503-29-8 ##### NA 918 Insecticide Organophosphorus
    Chlorthiophos III 77503-28-7 ##### NA 917 Insecticide Organophosphorus
    cis-Azodrin 919-44-8 58902 NA 482 Insecticide Organophosphorus
    cis-Methocrotophos 69632-93-5 ##### NA 143 Insecticide Organophosphorus
    Coumaphos 56-72-4 36501 165 Insecticide Organophosphorus
    Coumaphos, other related NA 1077 NA 161 90165 Insecticide Organophosphorus
    Coumithioate 572-48-5 ##### NA 141 Insecticide Organophosphorus
    Crotoxyphos 7700-17-6 58801 140 Insecticide Organophosphorus
    Crotoxyphos, other related NA 1076 NA 161 90140 Insecticide Organophosphorus
    Cyanofenphos 13067-93-1 ##### NA 131 Insecticide Organophosphorus
    Cyanophos 2636-26-2 ##### NA 131 Insecticide Organophosphorus
    Cyanthoate 3734-95-0 ##### NA 131 Insecticide Organophosphorus
    Cythioate 115-93-5 59501 NA 486 Insecticide Organophosphorus
    DDVP 62-73-7 84001 187 Insecticide, Organophosphorus
    Breakdown
    product
    DDVP, other related NA 1081 84001 90187 Insecticide Organophosphorus
    Demephion-O 682-80-4 ##### NA 143 Insecticide, Organophosphorus
    Breakdown
    product
    Demephion-S 2587-90-8 ##### NA 143 Insecticide Organophosphorus
    Demeton 8065-48-3 57601 566 Insecticide, Organophosphorus
    Nematicide
    Demeton-O 298-03-3 57602 NA 474 Insecticide Organophosphorus
    Demeton-O-methyl 867-27-6 58703 NA 480 Insecticide Organophosphorus
    Demeton-S 126-75-0 57603 NA 475 Insecticide Organophosphorus
    Demeton-S-methyl 919-86-8 NA 200 NA 200 Insecticide Organophosphorus
    Demeton-S-methyl (mixture) 8022-00-2 58701 4063 Insecticide Organophosphorus
    Demeton-S-methyl sulfone 17040-19-6 NA 183 NA 182 Breakdown Organophosphorus
    product,
    Insecticide
    Dequest 2010 phosphonate NA 579 NA 105 2496 N/A Organophosphorus
    Dialifor 10311-84-9 ##### 1799 Insecticide Organophosphorus
    Dialifor, other related NA 1138 NA 167 91799 Insecticide Organophosphorus
    Diamidafos 1754-58-1 ##### NA 879 Insecticide, Organophosphorus
    Nematicide
    Diazinon 333-41-5 57801 198 Insecticide Organophosphorus
    Diazoxon 962-58-3 NA 156 4064 Breakdown Organophosphorus
    product
    Dichlofenthion 97-17-6 28601 614 Insecticide, Organophosphorus
    Nematicide
    Dicrotophos 141-66-2 35201 72 Insecticide Organophosphorus
    Dimethoate 60-51-5 35001 216 Insecticide Organophosphorus
    Dimethoate-ethyl 116-01-8 ##### NA 147 Insecticide Organophosphorus
    Dioxabenzofos 3811-49-2 ##### NA 112 Insecticide Organophosphorus
    Dioxathion 78-34-2 37801 192 Insecticide Organophosphorus
    Dioxathion, other related NA 1083 NA 161 90192 Insecticide Organophosphorus
    Diphenprofos 59010-86-5 ##### NA 920 Insecticide Organophosphorus
    Disulfoton 298-04-4 32501 230 Insecticide, Organophosphorus
    Nematicide
    Disulfoton sulfone 216746 ##### NA 140 Insecticide Organophosphorus
    Disulfoton sulfoxide 216777 ##### NA 140 Breakdown Organophosphorus
    product
    Ditalimfos 5131-24-8 ##### NA 891 Fungicide Organophosphorus
    DMCP 3309-87-3 ##### NA 119 Insecticide Organophosphorus
    Edifenphos 17109-49-8 ##### 1964 Insecticide Organophosphorus
    Endothion 319315 ##### NA 146 Insecticide Organophosphorus
    EPBP 3792-59-4 ##### NA 155 Insecticide Organophosphorus
    EPN 2104-64-5 41801 263 Insecticide Organophosphorus
    Ethephon 16672-87-0 99801 1626 Plant Growth Organophosphorus
    Regulator
    Ethion 563-12-2 58401 268 Insecticide Organophosphorus
    Ethion, O-analog 17356-42-2 58402 NA 478 Breakdown Organophosphorus
    product
    Ethoprop 13194-48-4 41101 404 Insecticide, Organophosphorus
    Nematicide
    Ethyl (2- 5840-95-9 ##### NA 149 Insecticide Organophosphorus
    mercaptoethyl)carbamate, S-
    ester of O,O-dimethyl
    phosphorodithioate
    Ethyl hydrogen 1- 21921-96-0 ##### NA 148 N/A Organophosphorus
    propylphosphonate
    Etrimfos 38260-54-7 ##### NA 147 Insecticide Organophosphorus
    Famphur 52-85-7 59901 282 Insecticide Organophosphorus
    Famphur, O-analog 960-25-8 59902 NA 491 Breakdown Organophosphorus
    product
    Fenamiphos 22224-92-6 ##### 1857 Insecticide, Organophosphorus
    Nematicide
    Fenamiphos sulfone 31972-44-8 NA 156 4070 Breakdown Organophosphorus
    product
    Fenamiphos sulfoxide 31972-43-7 NA 156 4071 Breakdown Organophosphorus
    product
    Fenitrothion 122-14-5 ##### 2520 Insecticide Organophosphorus
    Fensulfothion 115-90-2 32701 181 Insecticide, Organophosphorus
    Nematicide
    Fenthion 55-38-9 53301 63 Insecticide, Organophosphorus
    Avicide
    Fenthion oxon 3254-63-5 ##### NA 143 Breakdown Organophosphorus
    product
    Fonofos 944-22-9 41701 254 Insecticide Organophosphorus
    Formothion 2540-82-1 ##### NA 143 Insecticide Organophosphorus
    Fosmethilan 83733-82-8 NA 208 NA 207 Insecticide Organophosphorus
    Fospirate 5598-52-7 ##### 1856 Insecticide Organophosphorus
    Fosthiazate 98886-44-3 ##### NA 109 N/A Organophosphorus
    Fosthietan 21548-32-3 ##### NA 928 Fumigant, Organophosphorus
    Nematicide
    Heptenophos 23560-59-0 ##### NA 122 Insecticide Organophosphorus
    Hexylthiofos 41495-67-4 ##### NA 132 Insecticide Organophosphorus
    Iodofenfos 18181-70-9 ##### NA 138 Insecticide Organophosphorus
    Iprobenfos 26087-47-8 NA 203 NA 202 Fungicide Organophosphorus
    IPSP 1432970 NA 208 NA 207 Insecticide Organophosphorus
    Isazophos 42509-80-8 ##### 2282 Insecticide Organophosphorus
    Isazophos-methyl 42509-83-1 ##### NA 136 Insecticide Organophosphorus
    Isocarbophos 24353-61-5 ##### 2414 Insecticide Organophosphorus
    Isochlorthion 2463-84-5 34502 NA 301 Insecticide Organophosphorus
    Isofephos 25311-71-1 ##### 2194 Insecticide Organophosphorus
    Isothioate 36614-38-7 NA 208 NA 207 Insecticide Organophosphorus
    Isoxathion 18854-01-8 57802 NA 476 Insecticide Organophosphorus
    Leptophos 21609-90-5 ##### 1676 Insecticide Organophosphorus
    Leptophos, other related NA 1135 NA 167 91676 Insecticide Organophosphorus
    Lythidathion 2669-32-1 ##### NA 147 Insecticide Organophosphorus
    Malaoxon NA 1054 NA 156 4076 Breakdown Organophosphorus
    product
    Malathion 121-75-5 57701 367 Insecticide Organophosphorus
    Mecarbam 2595-54-2 ##### NA 140 Insecticide Organophosphorus
    Mecarphon 29173-31-7 ##### NA 156 Insecticide Organophosphorus
    Menazon 78-57-9 ##### NA 134 N/A Organophosphorus
    Mephosfolan 950-10-7 ##### NA 131 Insecticide Organophosphorus
    Merphos 150-50-5 74901 293 Defoliant, Plant Organophosphorus
    Growth
    Regulator
    Merphos, other related NA 1088 NA 162 90293 Defoliant, Plant Organophosphorus
    Growth
    Regulator
    Merpofos 3568-56-7 ##### NA 129 N/A Organophosphorus
    Methacrifos 62610-77-9 NA 189 NA 188 Insecticide Organophosphorus
    Methamidophos 10265-92-6 ##### 1697 Insecticide, Organophosphorus
    Breakdown
    product
    Methidathion 950-37-8 ##### 1689 Insecticide Organophosphorus
    Methidathion OA NA 1065 ##### 5040 Insecticide Organophosphorus
    Methyl paraoxon 950-35-6 53502 4083 Breakdown Organophosphorus
    product
    Methyl parathion 298-00-0 53501 394 Insecticide, Organophosphorus
    Nematicide
    Methyl parathion, other related NA 1094 NA 162 90394 Insecticide, Organophosphorus
    Nematicide
    Methyl phenkapton 3735-23-7 ##### NA 142 N/A Organophosphorus
    Methyl trithion 953-17-3 58101 3531 Insecticide Organophosphorus
    Methyl-carbofenthion NA 843 NA 157 4057 Insecticide Organophosphorus
    Mevinphos 7786-34-7 15801 480 Insecticide Organophosphorus
    Mevinphos (stereochemistry 26718-65-0 NA 200 NA 200 Insecticide Organophosphorus
    unspecified)
    Mevinphos, other related NA 1103 NA 163 90480 Insecticide Organophosphorus
    Miral 42509-80-8 ##### 2689 Insecticide Organophosphorus
    Monocrotophos 6923-22-4 58901 52 Insecticide Organophosphorus
    Morphothion 144-41-2 ##### NA 143 Insecticide Organophosphorus
    Naled 300-76-5 34401 418 Insecticide Organophosphorus
    Naphthalophos 1491-41-4 ##### NA 117 Insecticide Organophosphorus
    O,O,S-Trimethyl 2953-29-9 ##### NA 161 Impurity Organophosphorus
    phosphorodithiate (as impurity)
    O,O-diethyl O- 2668-92-0 ##### NA 138 Insecticide Organophosphorus
    naphthaloximido
    phosphorothioate
    O,O-diethyl phosphoro 226542 NA 338 2508 Insecticide Organophosphorus
    chloridothionate
    O,O-Diethyl S-(4,6-dimethyl- 333-40-4 ##### NA 140 Insecticide Organophosphorus
    2-pyrimidinyl)
    phosphorodithioate
    O,O-diethyl-O-phenyl 32345-29-2 NA 337 2507 Insecticide Organophosphorus
    phosphorothioate
    O,O-dimethyl S-(2- 2674-91-1 58704 NA 481 Insecticide Organophosphorus
    (ethylsulfinyl)-1-methylethyl)
    phosphorothioate
    O-(2-chloro-4-nitrophenyl) O- 328-04-1 ##### NA 137 N/A Organophosphorus
    isopropyl
    ethylphosphonothioate
    O-(4-Nitrophenyl) O-phenyl 2665-30-7 ##### NA 158 N/A Organophosphorus
    methylphosphonothioate
    O-ethyl O-(4- 2703-13-1 ##### NA 117 N/A Organophosphorus
    (methylthio)phenyl)
    methylphosphonothioate
    O-Ethyl S-(4-methylphenyl) 333-43-7 ##### NA 149 N/A Organophosphorus
    ethylphosphonodithioate
    O-Methyl 2-nitro-4-tolyl 36001-88-4 ##### NA 157 N/A Organophosphorus
    isopropylphosphoramidothioate
    Omethoate 1113-02-6 35002 2285 Insecticide, Organophosphorus
    Breakdown
    product
    Oxydemeton-methyl 301-12-2 58702 382 Insecticide Organophosphorus
    Paraoxon 311-45-5 NA 155 4082 Breakdown Organophosphorus
    product
    Parathion 56-38-2 57501 459 Insecticide Organophosphorus
    Parathion 56-38-2 57401 NA 174 Insecticide, Organophosphorus
    Nematicide
    Parathion, other related NA 1099 NA 163 90459 Insecticide, Organophosphorus
    Nematicide
    Phenkapton 2275-14-1 ##### NA 139 Insecticide Organophosphorus
    Phenthoate 253180 ##### NA 889 Insecticide Organophosphorus
    Phorate 298-02-2 57201 478 Insecticide, Organophosphorus
    Nematicide
    Phorate sulfone 249924 NA 155 4084 Breakdown Organophosphorus
    product
    Phorate sulfoxide 249892 NA 155 4085 Breakdown Organophosphorus
    product
    Phoratoxon 2600-69-3 NA 155 4086 Breakdown Organophosphorus
    product
    Phoratoxon sulfone NA 1051 NA 155 4087 Breakdown Organophosphorus
    product
    Phoratoxon sulfoxide 249955 NA 155 4088 Breakdown Organophosphorus
    product
    Phosalone 2310-17-0 97701 479 Insecticide Organophosphorus
    Phosalone OA NA 1066 97701 5041 Insecticide, Organophosphorus
    Breakdown
    product
    Phosfolan 947-02-4 ##### NA 131 N/A Organophosphorus
    Phosmet 732-11-6 59201 335 Insecticide Organophosphorus
    Phosmetoxon 3735-33-9 59202 4089 Breakdown Organophosphorus
    product
    Phosnichlor 5826-76-6 34503 NA 302 Insecticide Organophosphorus
    Phosphamidon 13171-21-6 18201 482 Insecticide Organophosphorus
    Phosphamidon, other related NA 1104 NA 163 90482 Insecticide Organophosphorus
    Phostebupirim 96182-53-5 ##### 5122 Insecticide Organophosphorus
    Phoxim 14816-18-3 ##### NA 159 Insecticide Organophosphorus
    Phoxim-methyl 14816-16-1 ##### NA 159 Insecticide Organophosphorus
    Piperophos 24151-93-7 NA 219 NA 218 Herbicide Organophosphorus
    Pirimiphos ethyl 23505-41-1 ##### 2781 Insecticide Organophosphorus
    Pirimiphos ethyl, O-analog 36378-61-7 ##### NA 899 Breakdown Organophosphorus
    product
    Pirimiphos-methyl 29232-93-7 ##### 2217 Insecticide Organophosphorus
    Primidophos 39247-96-6 ##### NA 127 Insecticide Organophosphorus
    Profenofos 41198-08-7 ##### 2042 Insecticide Organophosphorus
    Propaphos 7292-16-2 NA 201 NA 201 Insecticide Organophosphorus
    Propetamphos 31218-83-4 ##### 2122 Insecticide Organophosphorus
    Propoxon 5823-13-2 ##### NA 139 Insecticide Organophosphorus
    Prothidathion 20276-83-9 ##### NA 141 Insecticide Organophosphorus
    Prothiofos 34643-46-4 ##### 4094 Insecticide Organophosphorus
    Prothion 5969-94-8 ##### NA 139 Insecticide Organophosphorus
    Prothoate 2275-18-5 ##### NA 140 Insecticide Organophosphorus
    Pyraclofos 77458-01-6 NA 183 NA 182 Insecticide Organophosphorus
    Pyrazophos 13457-18-6 ##### NA 149 Fungicide Organophosphorus
    Pyridiphenthion 119-12-0 53302 NA 450 Insecticide Organophosphorus
    Quinalphos 13593-03-8 ##### NA 145 Insecticide Organophosphorus
    Quinalphos-methyl 13593-08-3 ##### NA 145 Insecticide Organophosphorus
    Quinitofos 1776-83-6 ##### NA 149 Insecticide Organophosphorus
    Quinothion 22439-40-3 ##### NA 140 Insecticide Organophosphorus
    Ronnel 299-84-3 58301 517 Insecticide Organophosphorus
    S,S,S-tributyl 78-48-8 74801 190 Defoliant, Plant Organophosphorus
    phosphorotrithioate Growth
    Regulator
    S-(1,1-Dimethylethyl) O-ethyl 83318-76-7 ##### NA 104 Insecticide Organophosphorus
    ethylphosphonothioate
    S-(4-(1,1- 329-21-5 ##### NA 143 Insecticide Organophosphorus
    dimethylethyl)phenyl) O-ethyl
    ethylphosphonodithioate
    Sophamide 37032-15-8 ##### NA 144 Insecticide Organophosphorus
    Sulfotep 3689-24-5 79501 558 Insecticide Organophosphorus
    Sulfotep, other related NA 1111 NA 164 90558 Insecticide Organophosphorus
    Sulprofos 35400-43-2 ##### 2006 Insecticide Organophosphorus
    Sulprofos oxon 38527-90-1 ##### NA 125 Breakdown Organophosphorus
    product
    Temephos 3383-96-8 59001 1 Insecticide Organophosphorus
    Temephos sulfoxide 17210-55-8 59002 NA 483 Breakdown Organophosphorus
    product
    TEPP 107-49-3 79601 577 Insecticide Organophosphorus
    Terbufos 13071-79-9 ##### 2925 Insecticide, Organophosphorus
    Nematicide
    Terbufos sulfone 56070-16-7 ##### NA 140 Breakdown Organophosphorus
    product
    Terbufos sulfoxide 10548-10-4 ##### NA 140 Breakdown Organophosphorus
    product
    Tetrachlorvinphos 22248-79-9 83702 305 Insecticide Organophosphorus
    Tetrachlorvinphos 961-11-5 83701 NA 34 Insecticide Organophosphorus
    Thiometon 640-15-3 ##### NA 149 Insecticide Organophosphorus
    Thionazin 297-97-2 32401 2939 Insecticide Organophosphorus
    Thionazin, O-analog 7359-55-9 32402 NA 297 Insecticide, Organophosphorus
    Breakdown
    product
    Tolclofos-methyl 57018-04-9 ##### NA 106 Fungicide Organophosphorus
    Triazophos 24017-47-8 ##### 3543 Insecticide Organophosphorus
    Trichlorfon 52-68-6 57901 88 Insecticide Organophosphorus
    Trichloronat 327-98-0 ##### 5001 Insecticide Organophosphorus
    Vamidothion 2275-23-2 ##### 3544 Insecticide Organophosphorus
    3-iodo-2-propynyl butyl 55406-53-6 ##### 1938 Fungicide, Other Carbamate
    carbamate Wood
    Preservative
    6-Methyl-2-propyl-4- 2532-49-2 ##### NA 157 N/A Other Carbamate
    pyrimidinyl dimethylcarbamate
    Alanycarb 83130-01-2 NA 175 NA 47 Insecticide Other Carbamate
    Asulam 3337-71-1 ##### 5076 Herbicide Other Carbamate
    Asulam, sodium salt 2302-17-2 ##### 1746 Herbicide Other Carbamate
    Benfuracarb 82560-54-1 ##### NA 48 Insecticide Other Carbamate
    Chlorbufam 1967-16-4 ##### NA 157 Herbicide Other Carbamate
    Chlorprocarb 23121-99-5 ##### NA 136 Herbicide Other Carbamate
    Chlorpropham 101-21-3 18301 141 Herbicide, Other Carbamate
    Plant Growth
    Regulator
    Diethofencarb 87130-20-9 NA 184 NA 183 Fungicide Other Carbamate
    Dimetan 122-15-6 ##### NA 112 Insecticide Other Carbamate
    Dimetilan 644-64-4 90101 NA 844 Insecticide Other Carbamate
    Fenoxycarb 79127-80-3 ##### 2283 Insecticide, Other Carbamate
    Insect Growth
    Regulator
    Fenoxycarb 72490-01-8 NA 228 NA 228 Insecticide, Other Carbamate
    Insect Growth
    Regulator
    Isolan 119-38-0 ##### NA 155 Insecticide Other Carbamate
    Karbutilate 4849-32-5 97401 691 Herbicide Other Carbamate
    Mecarbinizid 27386-64-7 ##### NA 157 N/A Other Carbamate
    Nitrilacarb 29672-19-3 ##### NA 129 Insecticide Other Carbamate
    Potassium asulam 14089-43-1 ##### NA 893 Herbicide Other Carbamate
    Propamocarb 24579-73-5 ##### 2147 Fungicide Other Carbamate
    Propamocarb hydrochloride 25606-41-1 ##### 4022 Fungicide Other Carbamate
    Propham 122-42-9 47601 339 Herbicide, Other Carbamate
    Plant Growth
    Regulator
    Pyrolan 87-47-8 ##### NA 157 Insecticide Other Carbamate
    Swep 1918-18-9 84601 4098 N/A Other Carbamate
    Chlorfenapyr 122453-73-0 ##### 3938 Insecticide Pyrazole
    Pyrazoxyfen 71561-11-0 NA 189 NA 189 Herbicide Pyrazole
    Tebufenpyrad 119168-77-3 90102 NA 845 Insecticide Pyrazole
    (+−)-cis,trans-Deltamethrin 120710-23-8 ##### NA 120 Insecticide Pyrethroid
    (+−)-cis-Permethrin 52341-33-0 ##### NA 120 Insecticide Pyrethroid
    (S)-Cypermethrin 66841-24-5 ##### 3866 Insecticide Pyrethroid
    6-chloropiperonyl 2,2- 70-43-9 ##### NA 124 Insecticide Pyrethroid
    dimethyl-3-(2-
    methylpropenyl)cyclopropanecarboxylate
    Acrinathrin 101007-06-1 ##### NA 4 Insecticide Pyrethroid
    Allethrin 584-79-2 4001 12 Insecticide Pyrethroid
    Allethrin Coil NA 1163 4002 NA 163 Insecticide Pyrethroid
    Allethrin, other related NA 1070 NA 160 90012 Insecticide Pyrethroid
    B-fenvalerate 66267-77-4 ##### NA 903 Insecticide Pyrethroid
    Beta-cyfluthrin 68359-37-5 ##### 3956 Insecticide Pyrethroid
    Bifenthrin 82657-04-3 ##### 2300 Insecticide Pyrethroid
    Bioresmethrin 28434-01-7 97802 NA 855 Insecticide Pyrethroid
    Cismethrin 35764-59-1 97804 NA 857 Insecticide Pyrethroid
    Cyclethrin 97-11-0 4052 NA 69 N/A Pyrethroid
    Cycloprothrin 63935-38-6 NA 204 NA 203 Insecticide Pyrethroid
    Cyfluthrin 68359-37-5 ##### 2223 Insecticide Pyrethroid
    Cyhalothrin 68085-85-8 ##### NA 104 Insecticide Pyrethroid
    Cypermethrin (stereochemistry 52315-07-8 ##### NA 172 Insecticide Pyrethroid
    unspecified)
    Cypermethrin, alpha 67375-30-8 ##### NA 120 Insecticide Pyrethroid
    Cypermethrin, beta 65731-84-2 ##### 2171 Insecticide Pyrethroid
    Cypermethrin, theta 71697-59-1 NA 200 NA 199 Insecticide Pyrethroid
    Cyphenothrin 39515-40-7 ##### 3885 Insecticide Pyrethroid
    D-Allethrin 42534-61-2 4005 2293 Insecticide Pyrethroid
    D-allethrin, other related NA 1151 NA 168 92293 Insecticide Pyrethroid
    D-cis-trans Allethrin 42534-61-2 4005 NA 163 Insecticide Pyrethroid
    D-trans Allethrin 28057-48-9 4003 4038 Insecticide Pyrethroid
    D-trans allethrin, other related NA 1154 NA 173 94038 Insecticide Pyrethroid
    Deltamethrin 52918-63-5 97805 3010 Insecticide Pyrethroid
    Deltamethrin (isomer 52820-00-5 ##### NA 120 Insecticide Pyrethroid
    unspecified)
    Deltamethrin, other related NA 1153 NA 169 93010 Insecticide Pyrethroid
    Dimethrin 70-38-2 34101 NA 299 Insecticide Pyrethroid
    Empenthrin [(1R)isomers] 54406-48-3 NA 202 NA 202 Insecticide Pyrethroid
    Esbiothrin 28434-00-6 4004 4040 Insecticide Pyrethroid
    Esfenvalerate 66230-04-4 ##### 2321 Insecticide Pyrethroid
    Fenpropathrin 39515-41-8 ##### 2234 Insecticide Pyrethroid
    Fenpropathrin 64257-84-7 NA 201 NA 200 Insecticide Pyrethroid
    Fenvalerate 51630-58-1 ##### 1963 Insecticide Pyrethroid
    Fenvalerate 51630-58-1 ##### NA 173 Insecticide Pyrethroid
    Fenvalerate, other related NA 1143 NA 167 91963 Insecticide Pyrethroid
    Flucythrinate 70124-77-5 ##### 2168 Insecticide Pyrethroid
    Flumethrin 69770-45-2 NA 219 NA 218 Insecticide Pyrethroid
    Fluvalinate (stereochemistry 69409-94-5 ##### 2195 Insecticide Pyrethroid
    unspecified)
    Furethrin 17080-02-3 ##### NA 150 Insecticide Pyrethroid
    Halfenprox 111872-58-3 NA 189 NA 188 Insecticide Pyrethroid
    Imiprothrin 72963-72-5 4006 5327 Insecticide Pyrethroid
    Lambda cyhalothrin 91465-08-6 ##### 2297 Insecticide Pyrethroid
    Permethrin 52645-53-1 ##### 2008 Insecticide Pyrethroid
    Permethrin, other related NA 1146 NA 168 92008 Insecticide Pyrethroid
    Phenothrin 26002-80-2 69005 2093 Insecticide Pyrethroid
    Phenothrin, other related NA 1147 NA 168 92093 Insecticide Pyrethroid
    Prallethrin 23031-36-9 ##### 3985 Insecticide Pyrethroid
    Pyrethrins and pyrethroids, 68648-44-2 69007 NA 611 Insecticide Pyrethroid
    manufg. Residues
    Resmethrin 10453-86-8 97801 2119 Insecticide Pyrethroid
    Resmethrin, other related NA 1148 NA 168 92119 Insecticide Pyrethroid
    S-Bioallethrin 28434-00-6 4004 4039 Insecticide Pyrethroid
    Tau-fluvalinate 102851-06-9 NA 201 NA 200 Insecticide Pyrethroid
    Tefluthrin 79538-32-2 ##### 3839 Insecticide Pyrethroid
    Tetramethrin 7696-12-0 69003 1695 Insecticide Pyrethroid
    Tetramethrin, other related NA 1137 NA 167 91695 Insecticide Pyrethroid
    Tralomethrin 66841-25-6 ##### 2329 Insecticide Pyrethroid
    Transfluthrin 118712-89-3 NA 206 NA 205 Insecticide Pyrethroid
    (Poly-N-acetyl--D- 9012-76-4 ##### 2792 Plant Growth Animal derived
    glucosamine)-protein Regulator,
    Fungicide
    Ammoniated caseinate 9005-42-9 NA 539 3579 N/A Animal derived
    Androsterone 53-41-8 ##### NA 101 Deer Repellent Animal derived
    Animal gland extracts NA 63 NA 118 1345 Rodenticide Animal derived
    Animal glue NA 792 NA 147 3581 Rodenticide, Animal derived
    Bird Repellent
    Beef fat NA 637 NA 117 3585 Bait Animal derived
    Bone meal NA 584 NA 106 3589 N/A Animal derived
    Bone oil 8001-85-2 10801 78 Dog and Cat Animal derived
    Repellent
    Calcium salts of casein and soy NA 665 NA 123 1252 N/A Animal derived
    Casein 9000-71-9 NA 152 1075 N/A Animal derived
    Cat food NA 796 NA 147 3602 Bait Animal derived
    Cheese NA 222 NA 429 3604 Bait Animal derived
    Chitin 1398-61-4 ##### NA 109 Nematicide Animal derived
    Clam shells NA 797 NA 147 3611 N/A Animal derived
    Cod liver oil 8001-69-2 31609 2250 N/A Animal derived
    Dried blood 68911-49-9 611 1315 Dog and Cat Animal derived
    Repellent
    Dry milk solids NA 149 NA 284 1976 N/A Animal derived
    Egg shells NA 141 NA 275 3649 N/A Animal derived
    Eggs NA 802 NA 148 3648 N/A Animal derived
    Elanco empty gelatin capsules NA 142 NA 276 2543 N/A Animal derived
    Fish meal NA 123 NA 237 2571 N/A Animal derived
    Fish oil 8016-13-5 ##### 3658 Adjuvant, Deer Animal derived
    Repellent, Dog
    and Cat
    Repellent
    Game repellent NA 1490 NA 221 NA 221 Deer Repellent Animal derived
    Gardol 137-16-6 174 3210 Dog and Cat Animal derived
    Repellent
    Gelatin 9000-70-8 NA 222 3660 Insecticide Animal derived
    Gelatin capsules, R. P. Scherer NA 574 NA 104 2577 N/A Animal derived
    Hydrolyzed proteins NA 1355 NA 192 NA 192 Bait Animal derived
    Jaguar NA 76 NA 147 2146 Deer Repellent Animal derived
    Lard 61789-99-9 NA 143 3675 N/A Animal derived
    Lion waste NA 571 NA 103 1301 Deer Repellent Animal derived
    Meat NA 53 NA 100 3681 Bait Animal derived
    Meat meal NA 570 ##### 3682 Bait, Deer Animal derived
    Repellent, Dog
    and Cat
    Repellent
    Meat scraps NA 54 NA 101 3683 Bait Animal derived
    Meat stock, Hormel #6 NA 618 NA 112 2670 Bait Animal derived
    Milk 8049-98-7 NA 64 3564 N/A Animal derived
    Nutria meat NA 24 NA 36 3702 Bait Animal derived
    Oil of mink NA 10 NA14 1961 N/A Animal derived
    Oyster shells NA 808 NA 149 3714 N/A Animal derived
    Pig tasties NA 594 NA 107 3730 N/A Animal derived
    Powdered gelatin NA 760 NA 137 2827 N/A Animal derived
    Putrescent whole egg solids 51609-52-0 ##### 1935 Insecticide, Animal derived
    Deer Repellent
    Shellac 9000-59-3 NA 109 3378 N/A Animal derived
    Silkworm pupae NA 464 NA 828 2855 N/A Animal derived
    Sodium caseinate 9005-46-3 NA 836 3389 N/A Animal derived
    Sperm oil 8002-24-2 99701 NA 868 N/A Animal derived
    Whey NA 560 NA 101 3825 N/A Animal derived
    Wool NA 566 NA 102 3826 N/A Animal derived
    (−)-.alpha.-Cubebene 17699-14-8 ##### NA 130 Insecticide Botanical
    (7S)-Hydroprene 65733-18-8 ##### NA 107 Insect Growth Botanical
    Regulator
    1-naphthaleneacetamide 86-86-2 56001 422 Plant Growth Botanical,
    (NAD) Regulator Naphthalene acetic
    acid derivati
    2-methoxy-5-nitro phenol, 67233-85-6 ##### 5117 Plant Growth Botanical
    sodium salt Regulator
    2-Naphthyloxyacetamide NA 1401 NA 197 NA 196 Plant Growth Naphthalene acetic
    Regulator, acid derivati,
    Herbicide Botanical
    3,7-dimethyl-6-octanol 106-22-9 NA 129 2140 Insect Botanical
    Repellent
    3,7-dimethyl-6-octen-1-ol 150-84-5 NA 307 2522 Insect Botanical
    acetate Repellent
    Acacia 2591766 NA 696 2346 N/A Botanical
    Alfalfa NA 635 NA 116 3569 N/A Botanical
    Alfalfa meal NA 393 NA 714 3570 N/A Botanical
    Algin 9005-38-3 NA 715 3571 N/A Botanical
    Almond hulls NA 280 NA 547 3577 N/A Botanical
    Almond shells NA 636 NA 117 3578 N/A Botanical
    Alpha-ionone 127-41-3 ##### 1518 Dog and Cat Botanical
    Repellent
    Alpha-pinene polymer 31393-98-3 NA 153 3996 Insecticide Botanical
    Amycol potato alpha starch NA 272 NA 527 2387 N/A Botanical
    Apple pomace NA 262 NA 517 3582 N/A Botanical
    Avermectin 71751-41-2 ##### 2254 Insecticide Botanical
    Avermectin B1 65195-55-3 ##### NA 165 Insecticide Botanical
    Avermectin, other related NA 1156 NA 174 92254 Insecticide Botanical
    Azadirachtin 11141-17-6 ##### 2328 Insecticide, Botanical
    Nematicide
    Azadirachtin B 95507-03-2 ##### NA 989 Insecticide Botanical
    Balsam peru NA 660 NA 122 1146 N/A Botanical
    Barley straw NA 873 NA 160 5138 N/A Botanical
    Beeswax (yellow and white) NA 245 NA 494 3586 N/A Botanical
    Beet powder NA 246 NA 495 3587 N/A Botanical
    Beta-caryophyllene 87-44-5 NA 439 2188 N/A Botanical
    Beta-pinene polymer 68240-09-5 NA 153 3998 Insecticide Botanical
    Bran NA 638 NA 117 3590 N/A Botanical
    Bread crumbs NA 793 NA 147 3591 Bait Botanical
    Buffalo gourd root powder NA 238 NA 475 3928 N/A Botanical
    Calf's Milk Replacer NA 1320 NA 177 5741 N/A Botanical
    Canary seed NA 583 NA 105 3597 Bait Botanical
    Capsicum oleoresin 404-86-4 70701 470 Insecticide Botanical
    Cardboard NA 795 NA 147 3599 N/A Botanical
    Carrageenan 2591943 NA 437 3600 Adjuvant Botanical
    Carrots NA 226 NA 438 3601 N/A Botanical
    Chlorophyllin 11006-34-1 NA 191 NA 190 Fungicide, Inorganic-Copper,
    Microbiocide Botanical
    Cinerin I 25402-06-6 69009 NA 612 Insecticide Botanical
    Cinerin II 121-20-0 69010 NA 613 Insecticide Botanical
    Cinnamaldehyde 104-55-2 40506 2277 Dog and Cat Botanical
    Repellent,
    Fungicide, Dog
    and Cat
    Repellent
    Cinnamon NA 217 ##### 3607 Insecticide Botanical
    cis-Zeatin NA 1342 NA 191 NA 190 Plant Growth Botanical
    Regulator
    Citronellal 106-23-0 NA 223 NA 223 Insect Botanical
    Repellent
    Citronellol 106-22-9 NA 306 2139 Insecticide Botanical
    Citrus extract NA 1457 NA 216 NA 215 N/A Botanical
    Citrus meal NA 214 NA 407 3608 N/A Botanical
    Citrus pectin NA 215 NA 408 3609 N/A Botanical
    Citrus pulp NA 216 NA 409 3610 N/A Botanical
    Clarified hydrophobic extract 8002-65-1 25006 3979 Insecticide Botanical
    of neem oil
    Clarified hydrophobic neem oil 8002-65-1 25007 NA 172 Insecticide Botanical
    Cloves, Crushed NA 962 ##### 2333 Insecticide Botanical
    Coco shell flour NA 200 NA 392 3617 N/A Botanical
    Cocoa NA 207 NA 398 3613 N/A Botanical
    Cocoa shells NA 640 NA 117 3614 N/A Botanical
    Coffee grounds NA 581 NA 105 3619 N/A Botanical
    Components of etheric oils of NA 1360 NA 193 NA 192 Insecticide Botanical
    plant origin
    Cork NA 798 NA 147 3622 N/A Botanical
    Corn NA 879 NA 169 5144 Bait Botanical
    Corn cobs NA 193 NA 383 3624 N/A Botanical
    Corn flour NA 799 NA 147 3625 N/A Botanical
    Corn gluten meal 66071-96-3 ##### 2481 Herbicide Botanical
    Corn product, hydrolyzed NA 710 NA 130 2322 Herbicide Botanical
    Cotton NA 188 NA 376 3629 N/A Botanical
    Cotton fibre cord NA 189 NA 377 2482 N/A Botanical
    Cottonseed flour 12751-36-9 NA 129 2078 N/A Botanical
    Cottonseed meal NA 190 NA 378 3630 N/A Botanical
    Cracked oats NA 801 NA 148 3632 Bait Botanical
    Cracked wheat NA 192 NA 380 3633 Bait Botanical
    Creosote, wood 8021-39-4 25002 NA 202 Wood Botanical
    Preservative
    Cube extracts NA 958 71004 756 Insecticide Botanical
    Cytokinin 525-79-1 ##### 2082 Plant Growth Botanical
    Regulator
    Cytokinin (as kinetin) 525-79-1 ##### NA 172 Plant Growth Botanical
    Regulator
    Daphne oil NA 1354 NA 192 NA 192 Insect Botanical
    Repellent
    Derris resins other than NA 1260 71001 NA 172 Insecticide Botanical
    rotenone
    Desmodium NA 1560 NA 227 NA 227 Insecticide Botanical
    Digitalis 71-63-6 97002 NA 850 N/A Botanical
    Digitalis 1339-93-1 97002 NA 851 N/A Botanical
    Dihydroazadirachtin 108189-58-8 ##### 3994 Insecticide, Botanical
    Nematicide
    DMN 571-58-4 55802 5067 Plant Growth Botanical
    Regulator
    Douglas fir bark, ground NA 156 NA 292 3647 N/A Botanical
    Emamectin, benzoate 137512-74-4 ##### 4020 Insecticide Botanical
    Ethylene glycol ether of pinene 53404-49-2 42101 NA 363 Insecticide Botanical
    Eugenol 97-53-0 ##### 2095 Pheromone, Botanical
    Fragrance, Dog
    and Cat
    Repellent,
    Insecticide,
    Insect
    Repellent
    Fenugreek NA 121 NA 234 3657 N/A Botanical
    Flour NA 120 NA 232 3659 N/A Botanical
    Flowers of Chamomile NA 1267 ##### NA 173 Insecticide Botanical
    (Matricaria chamomilla and/or
    Anthemidis nobilis)
    Folic acid 59-30-3 NA 191 NA 190 Plant Growth Botanical
    Regulator
    Garlic 8000-78-0 ##### 2213 Insecticide Botanical
    Geraniol 106-24-1 ##### 309 Pheromone, Botanical
    Fragrance,
    Insecticide,
    Insect
    Repellent, Dog
    and Cat
    Repellent
    Gibberellic acid, 2-butoxyethyl 6550-86-3 43803 NA 371 Plant Growth Botanical
    ester Regulator
    Gibberellin A4 mixt. With 8030-53-3 ##### NA 952 Plant Growth Botanical
    gibberellin A7 Regulator
    Gibberellins 77-06-5 43801 310 Plant Growth Botanical
    Regulator
    Gibberellins, potassium salt 125-67-7 43802 771 Plant Growth Botanical
    Regulator
    Grape pomace NA 880 NA 169 5145 N/A Botanical
    Griseofulvin 126-07-8 ##### NA 150 N/A Botanical
    Ground corn cobs NA 732 NA 133 2583 N/A Botanical
    Ground oats NA 804 NA 148 3664 Bait Botanical
    Ground rice hulls NA 108 NA 212 2584 N/A Botanical
    Ground sesame plant NA 109 ##### 2585 Insecticide, Botanical
    Nematicide
    Guar gum 9000-30-0 NA 103 3666 Adjuvant Botanical
    Gum resins 9000-75-3 99401 NA 866 Adjuvant Botanical
    Gum Thus 2244967 84502 NA 834 Adjuvant Botanical
    Gum tragacanth 9000-65-1 NA 213 3218 Adjuvant Botanical
    Hearts of corn flour NA 573 NA 104 3667 N/A Botanical
    Hellebore alkaloids 1399-70-8 2001 NA 65 N/A Botanical
    Humic acid 1415-93-6 NA 134 2597 N/A Botanical
    Hydroprene 41096-46-2 ##### 2244 Insect Growth Botanical
    Regulator
    Indole 120-72-9 25000 2614 Insecticide, Botanical
    Insect
    Repellent, Dog
    and Cat
    Repellent
    Indole-3-acetic acid 87-51-4 ##### NA 106 Plant Growth Botanical
    Regulator
    Jasmolin I 4466-14-2 69011 NA 614 Insecticide Botanical
    Jasmolin II 1172-63-0 69012 NA 615 Insecticide Botanical
    Juniper tar oil 2231543 67203 NA 575 Insecticide Botanical
    Juniperus communis ext. 84603-69-0 67212 NA 582 Insecticide Botanical
    Larkspur alkaloid 41710-20-7 2202 NA 66 N/A Botanical
    Leaves of Eucalyptus NA 1277 ##### NA 174 Insecticide Botanical
    Leaves of Pennyroyal (Mentha NA 1278 ##### NA 174 Insecticide Botanical
    pulegium)
    Lignin NA 73 NA 140 2640 N/A Botanical
    Lilacin 118-34-3 67006 NA 573 N/A Botanical
    Linalool 78-70-6 ##### 2239 Insecticide, Botanical
    Insect
    Repellent,
    Fragrance
    Locust bean gum NA 738 NA 134 2647 Adjuvant Botanical
    Medicated feed NA 644 NA 118 3685 N/A Botanical
    Millet seed NA 38 NA 65 3692 Bait Botanical
    Mint Herbs NA 1280 ##### NA 174 Insecticide Botanical
    Montok pepper NA 851 NA 158 5012 Insecticide Botanical
    Myrica cerifera, extract 84929-34-0 ##### NA 123 N/A Botanical
    N6-Benzyladenine, mixt. with 53663-71-1 ##### NA 953 Plant Growth Botanical
    Gibberellins A4 and A7 Regulator
    NAA 86-87-3 56002 423 Plant Growth Naphthalene acetic
    Regulator acid derivati,
    Botanical
    NAA, ethyl ester 2122-70-5 56008 749 Plant Growth Naphthalene acetic
    Regulator acid derivati,
    Botanical
    Nicotine 54-11-5 56702 75 Insecticide Botanical
    Nicotine sulfate 65-30-5 56703 430 Insecticide Botanical
    NOA 120-23-0 55601 432 Plant Growth Naphthalene acetic
    Regulator acid derivati,
    Botanical
    Nonanoic acid 112-05-0 ##### 2739 Herbicide, Botanical
    Fungicide
    Oatmeal NA 806 NA 149 3704 Bait Botanical
    Oats NA 16 NA 26 3705 Bait Botanical
    Oil of cedarwood 8000-27-9 40505 1011 Insecticide, Botanical
    Fungicide
    Oil of hardwood NA 675 67201 1639 Microbiocide Botanical
    Oil of pine tar 2227495 67002 2246 Insecticide, Botanical
    Microbiocide
    Oils, cedarwood, Texan 68990-83-0 11524 NA 118 Insecticide, Botanical
    Fungicide
    Onion extract NA 1349 NA 192 NA 191 N/A Botanical
    Onions NA 807 NA 149 3711 N/A Botanical
    Orange pulp NA 9 NA 13 3712 N/A Botanical
    p-Menthane-3,8-diol 42822-86-6 11550 5255 Insect Botanical
    Repellent
    Paloja 9000-28-6 ##### NA 880 N/A Botanical
    Papain 9001-73-4 NA 149 3717 Rodenticide Botanical
    Paper NA 598 NA 107 3718 N/A Botanical
    Paprika NA 383 NA 692 3719 N/A Botanical
    Peanut butter NA 373 NA 681 2735 Bait Botanical
    Peanut shells NA 375 NA 683 3723 N/A Botanical
    Peanuts NA 374 NA 682 3533 Bait Botanical
    Peat moss NA 809 NA 149 3724 N/A Botanical
    Pecan shell flour NA 376 NA 684 3725 N/A Botanical
    Pectin 9000-69-5 NA 118 3726 N/A Botanical
    Pepper NA 1348 NA 192 NA 191 Insecticide, Botanical
    Deer Repellent
    Peppermint NA 365 NA 668 2332 Insecticide, Botanical
    Fragrance
    Phenylethyl propionate 122-70-3 ##### 2094 Fragrance, Botanical
    Pheromone,
    Insecticide,
    Insect
    Repellent, Dog
    and Cat
    Repellent
    Pine oil 2227495 67002 485 Insecticide, Botanical
    Microbiocide
    Pine soap NA 1032 NA 127 1993 Insecticide, Botanical
    Microbiocide
    Pine tar 8011-48-1 67204 1574 Insecticide, Botanical
    Microbiocide
    Pine tar oil 91995-59-4 67205 NA 576 Insecticide, Botanical
    Microbiocide
    Pinene 80-56-8 67004 2187 Insecticide Botanical
    Pinene 1330-16-1 67001 NA 572 Insecticide Botanical
    Plant carbolineums NA 1454 NA 215 NA 215 Insecticide, Botanical
    Fungicide
    Plant extract (derived from NA 917 ##### 5453 Nematicide Botanical
    Quercus falcata, Opuntia
    lindheimeri, Rhus aromatica,
    and Rhizophoria mangle
    tissues)
    Polymerized pinene NA 399 NA 722 2043 Insecticide Botanical
    Potatoes NA 436 NA 786 3772 N/A Botanical
    Poultry feed NA 437 NA 787 3773 N/A Botanical
    Pyrethrin coils NA 1165 69004 NA 164 Insecticide Botanical
    Pyrethrin I 121-21-1 NA 213 NA 213 Insecticide Botanical
    Pyrethrin II 121-29-9 69006 NA 610 Insecticide Botanical
    Pyrethrins 8003-34-7 69001 510 Insecticide Botanical
    Pyrethrins, other related NA 1108 NA 164 90510 Insecticide Botanical
    Pyrethrum narc NA 1000 69000 1461 Insecticide Botanical
    Pyrethrum powder other than 8003-34-7 69002 NA 164 Insecticide Botanical
    pyrethrins
    Quassia NA 450 NA 806 3778 Insecticide Botanical
    Quillaja 68990-67-0 NA 150 3779 N/A Botanical
    Raisins NA 647 NA 119 3780 Bait Botanical
    Red dog flour NA 452 NA 811 3782 N/A Botanical
    Red pepper NA 107 70703 1094 Dog and Cat Botanical
    Repellent
    Red squill glycoside 507-60-8 70801 514 Rodenticide Botanical
    Repellants (by smell) of animal NA 1373 NA 194 NA 193 Dog and Cat Botanical
    or plant origin Repellent, Deer
    Repellent
    Resins, oleo-, capsicum 8023-77-6 70704 NA 665 Insecticide Botanical
    Rice NA 812 NA 150 3783 N/A Botanical
    Rice hulls NA 813 NA 150 3784 N/A Botanical
    Rosemary NA 453 ##### 2331 N/A Botanical
    Rosin 9014-63-5 NA 812 3785 N/A Botanical
    Rosin oil 8002-16-2 40508 NA 341 N/A Botanical
    Rosin, partially dimerized NA 454 NA 813 3786 N/A Botanical
    Rosin, partially hydrogenated 65997-06-0 NA 150 3787 N/A Botanical
    Rotenone 83-79-4 71003 518 Insecticide Botanical
    Rotenone, other related NA 1109 NA 164 90518 Insecticide Botanical
    Rubber 2594048 NA 814 3788 N/A Botanical
    Ryanodine NA 1305 71502 NA 175 Insecticide Botanical
    Ryanodine alkaloid 15662-33-6 71501 520 Insecticide Botanical
    Rye flour NA 648 NA 119 3789 N/A Botanical
    Sabadilla alkaloids 2245180 2201 521 Insecticide Botanical
    Safrole 94-59-7 97901 3376 N/A Botanical
    Saponin 8047-15-2 97004 5033 N/A Botanical
    Sawdust NA 1306 ##### 1316 Adjuvant Botanical
    Scratch feed NA 649 NA 119 3792 N/A Botanical
    Sea-algae extract NA 1352 NA 192 NA 191 Plant Growth Botanical
    Regulator,
    Adjuvant
    Seaweed NA 814 NA 150 3793 N/A Botanical
    Sodium 2-nitrophenoxide 824-39-5 ##### 5118 Plant Growth Botanical
    Regulator
    Sodium 4-nitrophenoxide 824-78-2 ##### 5119 Plant Growth Botanical
    Regulator
    Sorghum, grain NA 478 NA 882 3904 N/A Botanical
    Soy flour NA 482 NA 886 3809 N/A Botanical
    Soy protein NA 483 NA 887 3810 N/A Botanical
    Soybean extract NA 1353 NA 192 NA 191 N/A Botanical
    Soybean hulls NA 481 NA 885 3807 N/A Botanical
    Soybean meal NA 817 NA 150 3808 N/A Botanical
    Squalane 111-01-3 45503 2887 N/A Botanical
    Sugarbeet meal NA 499 NA 910 3813 N/A Botanical
    Sunflower seeds NA 650 NA 119 3815 Bait Botanical
    Synthetic vegetable gums 9004-64-2 NA 921 1835 Adjuvant Botanical
    Tall oil 8002-26-4 67211 2912 Adjuvant Botanical
    Tall oil acids 61790-12-3 NA 124 1389 Adjuvant Botanical
    Tar oils, from distillation of 8002-29-7 67202 NA 574 Insecticide, Botanical
    wood tar Herbicide
    Thuringiensin, calcium 23526-02-5 6404 2941 Insecticide Botanical
    technical
    Thyme NA 527 ##### 2330 Insect Botanical
    Repellent,
    Insecticide
    Tobacco NA 1011 NA 959 3932 Insecticide Botanical
    Tobacco dust 8037-19-2 56704 NA 469 Insecticide Botanical
    Trimethoxybenzene 135-77-3 40515 5064 Insecticide, Botanical
    Insect
    Repellent, Dog
    and Cat
    Repellent
    Tung oil NA 547 NA 997 3821 N/A Botanical
    Verbenone 1196-01-6 ##### NA 108 Insect Botanical
    Repellent
    Walnut flour NA 555 NA 101 3823 N/A Botanical
    Walnut shells, ground NA 556 NA 101 2986 N/A Botanical
    Wheat NA 819 NA 151 3824 N/A Botanical
    Wheat flour NA 674 NA 125 1577 N/A Botanical
    White pepper NA 1311 NA 178 NA 177 Insecticide Botanical
    Wood powder NA 565 NA 102 1463 N/A Botanical
    Wood rosin 2245031 67208 NA 579 N/A Botanical
    Wood tar 91722-33-7 67206 NA 577 Insecticide Botanical
    Xanthan gum 11138-66-2 NA 102 2272 Adjuvant Botanical
    Agrobacterium radiobacter var NA 1435 NA 211 NA 210 Fungicide Microbial
    radiobacter
    Agrobacterium radiobacter NA 693 NA 127 1984 Fungicide Microbial
    Agrobacterium radiobacter NA 925 ##### NA 167 Fungicide Microbial
    (strain K84)
    Agrobacterium radiobacter NA 921 6474 5477 Fungicide Microbial
    strain K1026
    Agrobacterium vitis NA 1536 NA 224 NA 224 Fungicide Microbial
    Agrotis segetum granulosis NA 1391 NA 196 NA 195 Insecticide Microbial
    virus
    Ampelomyces quisqualis NA 270 NA 525 2385 Fungicide Microbial
    Ampelomyces quisqualis NA 1217 21007 NA 170 Fungicide Microbial
    isolate M-10
    Anagrapha falcifera multi- NA 862 ##### 5089 Insecticide Microbial
    nuclear polyhedrosis virus
    (AFMNPV)
    Aschersonia aleyrodis NA 1392 NA 196 NA 195 Insecticide Microbial
    Bacillus cereus strain UW85 NA 1218 ##### NA 170 Plant Growth Microbial
    Regulator
    Bacillus cereus, strain BP01 NA 903 NA 172 5183 Insecticide Microbial
    Bacillus popilliae NA 257 NA 509 2183 Fungicide Microbial
    Bacillus popilliae and B. lentimorbus NA 1219 54501 NA 170 Fungicide Microbial
    Bacillus sphaericus 143447-72-7 ##### 2274 Insecticide Microbial
    Bacillus sphaericus, serotype 143447-72-7 ##### 2409 Insecticide Microbial
    H-5A5B, strain 2362
    Bacillus subtilis GBO3 NA 855 ##### 3945 Fungicide Microbial
    Bacillus subtilis isolate B246 NA 1538 NA 225 NA 224 Fungicide Microbial
    Bacillus subtilis MBI 600 NA 864 ##### 5120 Fungicide Microbial
    Bacillus subtilis var. NA 1220 6480 NA 170 Fungicide, Microbial
    Amyloliquefaciens Strain Plant Growth
    FZB24 Regulator
    Bacillus thuringiensis (berliner) 68038-71-1 6400 86 Insecticide Microbial
    Bacillus thuringiensis 68038-71-1 6426 3843 Insecticide Microbial
    (berliner), subsp. Aizawai, GC-
    91 protein
    Bacillus thuringiensis 68038-71-1 6400 3856 Insecticide Microbial
    (berliner), subsp. Aizawai,
    serotype H-7
    Bacillus thuringiensis 68038-71-1 6401 3857 Insecticide Microbial
    (berliner), subsp. Israelensis,
    serotype H-14
    Bacillus thuringiensis 68038-71-1 6402 3970 Insecticide Microbial
    (berliner), subsp. Kurstaki
    strain SA-12
    Bacillus thuringiensis 68038-71-1 6402 3858 Insecticide Microbial
    (berliner), subsp. Kurstaki,
    serotype 3a, 3b
    Bacillus thuringiensis 68038-71-1 6424 3859 Insecticide Microbial
    (berliner), subsp. Kurstaki,
    strain EG2348
    Bacillus thuringiensis 68038-71-1 6423 3860 Insecticide Microbial
    (berliner), subsp. Kurstaki,
    strain EG2371
    Bacillus thuringiensis 68038-71-1 6422 3861 Insecticide Microbial
    (berliner), subsp. Kurstaki,
    strain EG2424
    Bacillus thuringiensis 68038-71-1 6402 3862 Insecticide Microbial
    (berliner), subsp. Kurstaki,
    strain SA-11
    Bacillus thuringiensis NA 1481 6400 3863 Insecticide Microbial
    (berliner), subsp. Morrisoni,
    serotype 8a8b
    Bacillus thuringiensis 68038-71-1 6400 3864 Insecticide Microbial
    (berliner), subsp. San Diego
    Bacillus thuringiensis 68038-71-1 6404 2410 Insecticide Microbial
    darstadiensis
    Bacillus thuringiensis sub. 68038-71-1 6448 5051 Insecticide Microbial
    Kurstaki strain EG7673
    coleopteran active toxin
    Bacillus thuringiensis sub. 68038-71-1 6447 5049 Insecticide Microbial
    Kurstaki strain EG7673
    lepidopteran active toxin
    Bacillus thuringiensis subsp. NA 1224 6403 NA 170 Insecticide Microbial
    Aizawai
    Bacillus thuringiensis subsp. 68038-71-1 6402 5004 Insecticide Microbial
    Kurstaki, genetically
    engineered strain AGRO1 by
    Agrevo
    Bacillus thuringiensis subsp. 68038-71-1 6402 5005 Insecticide Microbial
    Kurstaki, genetically
    engineered strain AGRO2 by
    Agrevo
    Bacillus thuringiensis subsp. NA 1232 ##### NA 171 Insecticide Microbial
    San Diego
    Bacillus thuringiensis subsp. 68038-71-1 6405 5043 Insecticide Microbial
    Tenebrionis
    Bacillus thuringiensis subspec. 68038-71-1 NA 169 3972 Insecticide Microbial
    Tenebrionis delta endotoxin
    Bacillus thuringiensis NA 1234 6476 NA 171 Insecticide Microbial
    subspecies Israelensis strain
    EG2215
    Bacillus thuringiensis 68038-71-1 6401 4018 Insecticide Microbial
    subspecies Israelensis, strain
    IPS-78
    Bacillus thuringiensis 68038-71-1 6407 4024 Insecticide Microbial
    subspecies kurstaki strain BMP
    123
    Bacillus thuringiensis 68038-71-1 6402 5010 Insecticide Microbial
    subspecies Kurstaki strain HD-
    1, lepidopteran active toxin
    Bacillus thuringiensis 68038-71-1 6453 3988 Insecticide Microbial
    subspecies kurstaki, genetically
    engineered strain EG7841
    lepidopteran active toxin
    Bacillus thuringiensis var. NA 1238 6445 NA 171 Insecticide Microbial
    kurstaki delta endotoxin protein
    as produced by the Cry1A(c)
    gene and its controlling
    sequences
    Bacillus thuringiensis var. 68038-71-1 6452 3978 Insecticide Microbial
    Kurstaki strain M-200 protein
    toxin
    Bacillus thuringiensis var. 68038-71-1 6402 3962 Insecticide Microbial
    Kurstaki, genetically
    engineered strain ECX 9441
    Bacillus thuringiensis var. 68038-71-1 6459 5325 Insecticide Microbial
    Kurstaki, genetically
    engineered strain EG7826
    Lepidopteran active toxin
    Neodiprion sertifer nuclear NA 1389 NA 196 NA 195 N/A Microbial
    polyhedrosis virus
    Nosema locustae spores NA 20 ##### 2137 Insecticide Microbial
    Nuclear polyhedrosis virus NA 1451 NA 215 NA 214 Insecticide Microbial
    Nuclear polyhedrosis virus of NA 1430 NA 213 NA 213 N/A Microbial
    Helicoverpea zea
    Nuclear polyhedrosis virus of NA 1510 NA 222 NA 222 Insecticide Microbial
    red-headed pine sawfly
    Nystatin (streotomyces 1400-61-9 ##### NA 115 N/A Microbial
    noursei) (withdrawn: 23614-R:
    pm24)
    Paecilomyces fumosoroseus NA 831 ##### 3964 Insecticide Microbial
    apopka strain 97
    Paecilomyces Lilacinus Strain NA 1439 NA 213 NA 213 Insecticide Microbial
    251
    Penicillin G, potassium salt NA 666 NA 123 1283 N/A Microbial
    Peniophora gigantea NA 1462 NA 217 NA 216 Fungicide Microbial
    Phlebiopsis gigantea NA 1388 NA 196 NA 195 Fungicide Microbial
    Phytophthora palmivora, NA 860 ##### 5078 Herbicide Microbial
    chlamydospores of
    Polyhedral inclusion bodies of NA 593 ##### 2009 Insecticide Microbial
    Douglas fir tussock moth
    nuclear polyhedrosis virus
    Polyhedral inclusion bodies of NA 1289 ##### NA 175 Insecticide Microbial
    gypsy moth nucleopolyhedrosis
    virus
    Polyhedral inclusion bodies of NA 1290 ##### NA 175 Insecticide Microbial
    N. sertifer
    Polyhedral occlusion bodies NA 835 ##### 4028 Insecticide Microbial
    (OB's) of the nuclear
    polyhedrosis virus of
    Helicoverpa zea (corn
    earworm)
    Polyhedral occlusion bodies NA 1292 ##### NA 175 Insecticide Microbial
    (OBs) of the nuclear
    polyhedrosis virus of
    Autographa californica (alfalfa
    looper)
    Polyhedral occlusion bodies NA 830 NA 153 4007 Insecticide Microbial
    (OBs) of the nuclear
    polyhedrosis virus of
    Spodoptera exigua
    Polyhedral occlusion bodies of NA 1293 ##### NA 175 Insecticide Microbial
    the beet armyworm nuclear
    polyhedrosis virus
    Pseudomonas aureofaciens NA 1296 6473 NA 175 Fungicide Microbial
    strain Tx-1
    Pseudomonas cepacia type NA 449 6419 3926 Fungicide, Microbial
    Wisconsin Nematicide
    Pseudomonas chlororaphis NA 902 NA 172 5182 Fungicide Microbial
    Pseudomonas chlororaphis NA 1489 6478 NA 220 Fungicide Microbial
    strain 63-28
    Pseudomonas fluorescens EG- NA 858 6440 5045 Fungicide Microbial
    1053
    Pseudomonas fluorescens NA 867 6439 3949 Fungicide Microbial
    1629RS
    Pseudomonas fluorescens NA 1020 6438 2842 Fungicide Microbial
    A506
    Pseudomonas fluorescens NA 868 6420 3968 Fungicide Microbial
    strain NCIB 12089
    Pseudomonas syringae strain NA 897 NA 171 3950 N/A Microbial
    AGS31 Psedomonas syringae
    strain PS31
    Pseudomonas syringae strain NA 836 6451 3967 Fungicide Microbial
    ESC-11
    Pseudomonas syringae, strain 68602-93-7 6411 2824 Fungicide Microbial
    742 RS
    Pseudomonas syringae, strain 68583-32-4 6441 3960 Fungicide Microbial
    ESC-10
    Puccinia canaliculata NA 865 ##### 5121 Herbicide Microbial
    (Schweinitz) Lagerheim
    (ATCC #40199)
    QST 713 strain of dried NA 915 6479 5447 Fungicide Microbial
    Bacillus subtilis
    Rabbit Calicivirus NA 1441 NA 214 NA 213 Rodent Microbial
    Repellent
    Rhizobium leguminosarum NA 1556 NA 226 NA 226 Insecticide Microbial
    biovar phaseoli
    Rhizobium leguminosarum NA 1557 NA 226 NA 226 Insecticide Microbial
    viciaeTJ 9
    Rhizobium meliloti NA 1558 NA 227 NA 226 Insecticide Microbial
    Spinosad 131929-60-7 ##### 3983 Insecticide Microbial
    Spinosyn D 131929-63-0 ##### NA 907 Insecticide Microbial
    Spores and mycelium spores of NA 1446 NA 214 NA 214 Fungicide Microbial
    Phlebiopsis gigantea
    Spores of Bacillus popilliae NA 1310 54502 NA 176 Fungicide Microbial
    Spores of Gliocladium NA 1453 NA 215 NA 215 Fungicide Microbial
    catenulatum
    Streptomyces griseoviridis NA 875 ##### 3937 Fungicide Microbial
    strain K61
    Summerfruit tortrix moth NA 1491 NA 221 NA 221 Insecticide Microbial
    granulosis virus
    Tomato mosaic virus NA 1387 NA 196 NA 195 N/A Microbial
    Trichoderma harzianum 67892-34-6 ##### NA 106 Fungicide Microbial
    (ATCC 20476)
    Trichoderma harzianum rifai 67892-31-3 ##### 3977 Fungicide Microbial
    strain KRL-AG2
    Trichoderma harzianum Rifai 67892-31-3 ##### 4016 Fungicide Microbial
    strain T-39
    Trichoderma polysporum 67892-31-3 ##### NA 176 Fungicide Microbial
    (ATCC 20475)
    Trichoderma polysporum rifai NA 1067 NA 159 5101 N/A Microbial
    Verticillium dahliae Kleb. NA 1386 NA 196 NA 195 Fungicide Microbial
    Verticillium lecanii 67892-35-7 6421 NA 96 Insecticide Microbial
    Xanthomonas campestris pv. NA 910 NA 174 5317 Herbicide Microbial
    Poannua
    Yeast NA 652 NA 119 3827 N/A Microbial
    Allyl isothiocyanate 57-06-7 4901 1010 Insecticide Oil - essential
    Almond, bitter 8013-76-1 NA 546 3576 N/A Oil - essential
    Aloe vera oil NA 918 NA 175 5454 N/A Oil - essential
    Blend of oils: of lemongrass, of NA 1499 NA 221 NA 221 Insecticide Oil - essential
    citronella, of orange, of
    bergamot; geraniol, ionone
    alpha, methyl salicylate and
    allylisothioc
    Camphor 76-22-2 15602 102 Insecticide, Oil - essential
    Fungicide,
    Microbiocide
    Camphor oil 8008-51-3 15601 NA 142 Insecticide, Oil - essential
    Fungicide,
    Microbiocide
    Canadian balsam 8007-47-4 67209 NA 580 Insecticide, Oil - essential
    Fungicide
    Cedar leaf oil 8007-20-3 40507 NA 340 Insecticide, Oil - essential
    Fungicide
    Cinnamon oil NA 922 NA 175 5577 N/A Oil - essential
    Clove oil 8000-34-8 ##### 5018 N/A Oil - essential
    Essential oils 8014-17-3 NA 121 873 Insecticide Oil - essential
    Eucalyptus oil 8000-48-4 40503 281 Insect Oil - essential
    Repellent,
    Insecticide
    Fir needle oil 8021-28-1 ##### NA 110 N/A Oil - essential
    Lavandin oil 8022-15-9 40500 5017 Insect Oil - essential
    Repellent,
    Insecticide,
    Dog and Cat
    Repellent
    Lemon peel oil 8020-19-7 40518 NA 346 N/A Oil - essential
    Lime Oil 8008-26-2 NA 213 NA 212 Insecticide Oil - essential
    Limonene 138-86-3 79701 979 Insect Oil - essential
    Repellent,
    Insecticide,
    Dog and Cat
    Repellent
    Limonene 138-86-3 79701 2531 Insecticide Oil - essential
    Mixture citronella oil, citrus NA 1493 NA 221 NA 221 Insect Oil - essential
    oil, eucalyptus oil, pine oil Repellent
    Oil of ambergis 8038-65-1 ##### NA 105 N/A Oil - essential
    Oil of anise 8007-70-3 4301 1051 Insect Oil - essential
    Repellent,
    Insecticide,
    Dog and Cat
    Repellent
    Oil of bay 8006-78-8 40520 2072 N/A Oil - essential
    Oil of bergamot 8007-75-8 ##### 1517 Insect Oil - essential
    Repellent,
    Insecticide,
    Dog and Cat
    Repellent
    Oil of black pepper NA 1521 NA 223 NA 223 Insecticide Oil - essential
    Oil of cajeput 8008-98-8 40504 NA 339 N/A Oil - essential
    Oil of camphor sassafrassy 8006-80-2 15603 897 N/A Oil - essential
    Oil of chamomile (Matricaria 8002-66-2 ##### NA 104 Insecticide Oil - essential
    chamomilla and/or Anthemidis
    nobilis)
    Oil of chenopodium 8006-99-3 NA 18 1524 N/A Oil - essential
    Oil of citronella 8000-29-1 21901 143 Insect Oil - essential
    Repellent, Dog
    and Cat
    Repellent
    Oil of citrus NA 13 NA 19 1931 Insect Oil - essential
    Repellent
    Oil of geranium 8000-46-2 ##### 1887 Fragrance Oil - essential
    Oil of jasmine 8022-96-6 40501 5063 Insecticide Oil - essential
    Oil of jojoba 61789-91-1 67200 3833 Insecticide, Oil - essential
    Insect
    Repellent,
    Fungicide, Dog
    and Cat
    Repellent
    Oil of lavender 8000-28-0 ##### 1888 Insecticide Oil - essential
    Oil of lemon 8008-56-8 NA 120 440 N/A Oil - essential
    Oil of lemongrass 5392-40-5 40510 1009 Insecticide, Oil - essential
    Pheromone
    Oil of lemongrass 2229107 40502 1136 Insect Oil - essential
    Repellent,
    Insecticide
    Oil of mustard 57-06-7 4901 1153 Insect Oil - essential
    Repellent,
    Insecticide,
    Dog and Cat
    Repellent
    Oil of orange 8008-57-9 40517 441 Insect Oil - essential
    Repellent,
    Insecticide,
    Dog and Cat
    Repellent
    Oil of pennyroyal 8007-44-1 40509 1325 Insecticide Oil - essential
    Oil of peppermint 8006-90-4 NA 669 2058 Insecticide Oil - essential
    Oil of rosemary 8000-25-7 ##### 5450 Insecticide Oil - essential
    Oil of rue 8014-29-7 40519 2206 N/A Oil - essential
    Oil of spearmint 8008-79-5 ##### 1508 N/A Oil - essential
    Oil of thyme 8007-46-3 ##### NA 159 N/A Oil - essential
    Oil of wintergreen 119-36-8 76601 746 Insecticide Oil - essential
    Oils, tea-tree 68647-73-4 28853 NA 211 N/A Oil - essential
    Orange pith oil NA 1461 NA 217 NA 216 Insecticide Oil - essential
    Perfume, cherry fragrance oil NA 751 NA 136 2743 Fragrance Oil - essential
    #493
    Phytelene of marigold 70892-20-5 ##### NA 976 N/A Oil - essential
    Phytelene of marigold 84776-23-8 ##### NA 977 N/A Oil - essential
    Tansy, sage and lavender NA 1452 NA 215 NA 214 Insecticide Oil - essential
    extracts
    Vanillin 121-33-5 ##### 5149 N/A Oil - essential
    Canola oil 120962-03-0 11332 5332 Insecticide, Oil - vegetable
    Adjuvant
    Castor oil 8001-79-4 31608 1013 Rodenticide, Oil - vegetable
    Insecticide,
    Insect
    Repellent
    Coconut oil 8001-31-8 ##### NA 124 N/A Oil - vegetable
    Coconut oil monoethanolamine 68140-00-1 69179 1361 Adjuvant, Oil - vegetable
    Soap/Surfactant
    Corn oil 8001-30-7 NA 117 3626 N/A Oil - vegetable
    Cottonseed oil 8001-29-4 31602 1015 Insecticide Oil - vegetable
    Emulsifiable methylated NA 907 NA 173 5224 Insecticide, Oil - vegetable
    vegetable oil Adjuvant
    Fir needle oil, siberian 8021-29-2 NA 236 2570 N/A Oil - vegetable
    Hydrogenated castor oil 8001-78-3 31604 3830 Bird Repellent Oil - vegetable
    Hydrogenated soybean oil 8016-70-4 NA 186 3670 N/A Oil - vegetable
    Hydrogenated vegetable oils NA 881 NA 169 5146 N/A Oil - vegetable
    Linseed oil with driers NA 61 NA 116 2645 N/A Oil - vegetable
    Linseed oil, boiled 68553-15-1 NA 115 2644 N/A Oil - vegetable
    Methyl soyate 68919-53-9 NA 146 3519 Adjuvant Oil - vegetable
    Oil of linseed 8001-26-1 31603 2248 N/A Oil - vegetable
    Olive oil 8001-25-0 31610 3710 N/A Oil - vegetable
    Palm oil NA 749 NA 136 2731 N/A Oil - vegetable
    Peanut oil 2227315 NA 118 3722 N/A Oil - vegetable
    Plant oils (including rape seed NA 1351 NA 192 NA 191 Insecticide Oil - vegetable
    oil)
    Rapeseed oil 8002-13-9 NA 220 NA 219 Insecticide Oil - vegetable
    Safflower oil 8001-23-8 NA 124 1510 N/A Oil - vegetable
    Sesame oil 8008-74-0 72401 1221 N/A Oil - vegetable
    Soybean oil 8001-22-7 31605 2335 Insecticide, Oil - vegetable
    Adjuvant
    Vegetable oil 8008-89-7 NA 111 1231 Insecticide Oil - vegetable
    Vegetable oil modified NA 552 NA 100 2981 N/A Oil - vegetable
    phenolic resin
    Vegetable wax 8001-39-6 99501 1441 N/A Oil - vegetable
    Weed oil NA 558 NA 101 1694 N/A Oil - vegetable
    Wheat germ oil NA 559 NA 101 2988 N/A Oil - vegetable
    (1R-exo)-Brevicomin 20290-99-7 ##### NA 106 Pheromone Pheromone
    (4E-7Z)-4,7-Tridecadien-1-yl- NA 1428 NA 199 NA 198 Pheromone Pheromone
    acetate
    (4Z-9Z)-7,9-Dodecadien-1-ol NA 1412 NA 198 NA 197 Pheromone Pheromone
    (E)-5-decen-1-ol 56578-18-8 78038 5315 Pheromone Pheromone
    (E)-10-Dodecenyl acetate 35153-09-4 NA 187 NA 186 Pheromone Pheromone
    (E)-11-Tetradecenyl acetate 33189-72-9 ##### 5022 Pheromone Pheromone
    (E)-2,6-dimethyl-2,6- 141-27-5 NA 21 3307 Pheromone Pheromone
    octadienal
    (E)-4-tridecen-1-yl-acetate 72269-48-8 ##### 2199 Pheromone Pheromone
    (E)-5-Decenol 56578-18-8 78038 3974 Pheromone Pheromone
    (E)-5-Decenyl acetate 38421-90-8 ##### 3975 Pheromone Pheromone
    (E)-6-dodecenyl acetate 29868-16-4 ##### NA 958 Pheromone Pheromone
    (E)-9-decen-1-ol 56578-18-8 78038 5071 Pheromone Pheromone
    (E)-9-dodecen-1-ol, acetate 35148-19-7 ##### 2141 Pheromone Pheromone
    (E)-9-Tricosene 35857-62-6 NA 200 NA 199 Pheromone Pheromone
    (E)7-(Z)9-Dodecadienyl NA 1413 NA 198 NA 197 Pheromone Pheromone
    acetate
    (E,Z)-3,13-octadecadien-1-ol 53120-26-6 ##### NA 955 Pheromone Pheromone
    acetate
    (E/Z)-8-Dodecenyl acetate NA 1415 NA 198 NA 197 Pheromone Pheromone
    (R,Z)-5-(1-decenyl) dihydro-2- 64726-91-6 ##### 2096 Pheromone Pheromone
    (3H)-furanone
    (Z)-(3,3- 26532-24-1 ##### 5081 Pheromone Pheromone
    dimethylcyclohexylidene)acetaldehyde
    (Z)-11-hexadecen-1-ol 56683-54-6 ##### NA 971 Pheromone Pheromone
    (Z)-11-Hexadecen-1-ol 56683-54-6 NA 193 NA 192 Pheromone Pheromone
    (Z)-11-hexadecenal 53939-28-9 ##### 2126 Pheromone Pheromone
    (Z)-11-hexadecenyl acetate 60037-58-3 ##### NA 111 Pheromone Pheromone
    (Z)-11-Tetradecen-1-yl-acetate 20711-10-8 NA 199 NA 199 Pheromone Pheromone
    (Z)-11-Tetradecenyl acetate 20711-10-8 ##### 5023 Pheromone Pheromone
    (Z)-13-Octadecanol NA 1423 NA 199 NA 198 Pheromone Pheromone
    (Z)-13-Octadecenal 58594-45-9 ##### NA 111 Pheromone Pheromone
    (Z)-13-Octadecenyl acetate 34010-21-4 ##### 5316 Pheromone Pheromone
    (Z)-2-(3,3-dimethyl cyclo 26532-23-0 ##### 5079 Pheromone Pheromone
    hexylidene)ethanol
    (Z)-3-Methyl-6-isopropenyl--9- NA 1420 NA 198 NA 198 Pheromone Pheromone
    decen-1-yl acetate
    (Z)-3-Methyl-6-isopropenyl- NA 1419 NA 198 NA 198 Pheromone Pheromone
    3,4-decadien-1-yl
    (Z)-4-tridecen-l-yl-acetate 65954-19-0 ##### 2200 Pheromone Pheromone
    (Z)-5-Decenyl acetate 67446-07-5 NA 198 NA 197 Pheromone Pheromone
    (Z)-5-Dodecen-1-yl acetate 16676-96-3 NA 187 NA 186 Pheromone Pheromone
    (Z)-6-dodecenyl acetate 16974-12-2 ##### NA 957 Pheromone Pheromone
    (Z)-6-Heneicosane-11-one 54844-65-4 ##### NA 110 Pheromone Pheromone
    (Z)-7-hexadecenal 56797-40-1 ##### NA 972 Pheromone Pheromone
    (Z)-7-Tetradecanol NA 1427 NA 199 NA 198 Pheromone Pheromone
    (Z)-7-Tetradecenal 65128-96-3 NA 187 NA 186 Pheromone Pheromone
    (Z)-9-dodecenyl acetate 16974-11-1 ##### 2142 Pheromone Pheromone
    (Z)-9-hexadecenal 56219-04-6 ##### NA 973 Pheromone Pheromone
    (Z)-9-tetradecen-1-ol 35153-15-2 ##### 5618 Pheromone Pheromone
    (Z)-9-tetradecenal 53939-27-8 ##### 2209 Pheromone Pheromone
    (Z)-9-Tetradecenyl acetate 16725-53-4 NA 187 NA 186 Pheromone Pheromone
    (Z)-9-Tricosene 27519-02-4 ##### NA 883 Pheromone Pheromone
    (Z,E) 7,11-hexadecaclien-1-ol NA 1144 NA 168 91997 Pheromone Pheromone
    acetate, other related
    (Z,E)-7,11-hexadecadien-1-yl 51607-94-4 ##### 1997 Pheromone Pheromone
    acetate
    (Z,E)-7,11-hexadecadien-1-yl 53042-79-8 ##### NA 933 Pheromone Pheromone
    acetate
    (Z,E)-8,10-dodecadienyl NA 1561 NA 227 NA 227 Pheromone Pheromone
    acetate
    (Z,E)-9,11-Tetradecadien-1-yl 50767-79-8 NA 199 NA 198 Pheromone Pheromone
    acetate
    (Z,E)-9,12-tetradecadienyl 31654-77-0 ##### 5617 Pheromone Pheromone
    acetate
    (Z,Z) 7,11-hexadecadien-1-ol NA 1145 NA 168 91998 Pheromone Pheromone
    acetate, other related
    (Z,Z) Octadienyl acetate NA 1422 NA 199 NA 198 Pheromone Pheromone
    (Z,Z)-11,13-hexadecadienal 71317-73-2 711 5314 Pheromone Pheromone
    (Z,Z)-3,13-octadecadien-1-ol 53120-27-7 ##### NA 954 Pheromone Pheromone
    acetate
    (Z,Z)-7,11-hexadecadien-1-yl 52207-99-5 ##### 1998 Pheromone Pheromone
    acetate
    (Z,Z)-7,11-Hexadecadienyl 52207-99-5 NA 198 NA 197 Pheromone Pheromone
    acetate
    1,7-Dioxaspiro-5,5-undecane 180-84-7 NA 186 NA 186 Pheromone Pheromone
    1-Methylbutyl decanoate 55195-26-1 ##### NA 100 Pheromone Pheromone
    1-Octen-3-ol 3391-86-4 69037 4029 Pheromone, Pheromone
    Fragrance,
    Insect
    Repellent, Dog
    and Cat
    Repellent
    11-(E)-Tetradecen-1-ol 35153-18-5 ##### 5108 Pheromone Pheromone
    11-(Z)-Tetradecen-1-ol 34010-15-6 ##### NA 109 Pheromone Pheromone
    2-cyclopenten-1-one, 2- 80-71-7 4049 NA 68 Pheromone, Pheromone
    hydroxy-3-methyl- Fragrance
    2-methyl-7(R),8(S)-epoxy 29804-22-6 ##### 2165 Pheromone Pheromone
    octadecane
    3(S)-Methyl-6-isopropenyl-9- NA 1535 NA 224 NA 224 Pheromone Pheromone
    dodecadien-1yl acetate
    3,7,11-trimethyl-2,6,10- 4601-84-0 NA 983 2269 Pheromone Pheromone
    dodecatriene-1-ol
    3-Methyl-2-cyclohexen-1-one 1193-18-6 ##### NA 124 Insect Pheromone
    Repellent,
    Pheromone
    4-(p-acetoxyphenyl)-2- 609379 ##### NA 106 Pheromone Pheromone
    butanone
    4-Methyl-3-heptanol 14979-39-6 ##### NA 962 Pheromone Pheromone
    7,11-hexadecadien-1-ol, acetate 50933-33-0 ##### NA 934 Pheromone Pheromone
    7,8-Epoxi-2-methyl-octadecane NA 1417 NA 198 NA 197 Pheromone Pheromone
    8-dodecene-1-ol, other related NA 1150 NA 168 92253 Pheromone Pheromone
    9-tetradecen-1-ol, formate, (Z)- 56218-79-2 ##### NA 967 Pheromone Pheromone
    Acetaldehyde,(3,3- 26532-25-2 ##### 5080 Pheromone Pheromone
    dimethylcyclohexylidene)-,(E)
    beta-Farnesene 18794-84-8 ##### NA 110 Pheromone Pheromone
    Cis-11-tetradecenyl acetate 20711-10-8 ##### 5038 Pheromone Pheromone
    Distilled cubeb oil 8007-87-2 ##### NA 960 Pheromone Pheromone
    Dodecadienal NA 1547 NA 226 NA 225 Pheromone Pheromone
    E,E-8,10-dodecadien-1-ol 33956-49-9 ##### 1851 Pheromone Pheromone
    E-3,3-dimethyl-delta,alpha- NA 951 NA 315 2193 Pheromone Pheromone
    cyclohexane ethanal
    E-8-dodecene NA 1532 NA 224 NA 224 Pheromone Pheromone
    E-8-dodecenyl acetate 38363-29-0 ##### 2252 Pheromone Pheromone
    Farnesol 4602-84-0 ##### 2564 Pheromone Pheromone
    Frontalin 28401-39-0 ##### NA 985 Pheromone Pheromone
    Frontalin + alpha-pinene 12701-72-3 ##### NA 986 Pheromone Pheromone
    mixture
    German cockroach pheromone NA 871 29028 5132 Pheromone Pheromone
    Isoamyl acetate 123-92-2 NA 167 1422 Fragrance Pheromone
    Isomate LBAM NA 1438 NA 213 NA 212 Pheromone Pheromone
    Isomate OFM Rosso NA 1426 NA 213 NA 212 Pheromone Pheromone
    Lauryl alcohol 112-53-8 1509 2343 Pheromone, Pheromone,
    Adjuvant Alcohol/Ether
    Luretape (Grandlure) 11104-05-5 ##### NA 923 Pheromone Pheromone
    Methyl-trans-6-nonenoate NA 1421 NA 199 NA 198 Pheromone Pheromone
    Multilure 60018-97-5 ##### NA 963 Pheromone Pheromone
    Multistriatin 59014-03-8 ##### NA 961 Pheromone Pheromone
    Muscalure 27519-02-4 ##### 1858 Pheromone Pheromone
    Myrcene 123-35-3 ##### 2189 Pheromone Pheromone
    Nerolidol 7212-44-4 ##### 2268 Pheromone Pheromone
    Nerolidol 7212-44-4 ##### 2701 Pheromone Pheromone
    Pentyl valerate 2173-56-0 ##### 1809 Pheromone Pheromone
    Periplanone B 61228-92-0 ##### 2766 Pheromone Pheromone
    Pherodim NA 1424 NA 199 NA 198 Pheromone Pheromone
    Pronumone NA 1425 NA 199 NA 198 Pheromone Pheromone
    Serricornin NA 1343 NA 191 NA 190 Pheromone Pheromone
    Tetradecanal 124-25-4 ##### NA 975 Pheromone Pheromone
    Trans-11-tetradecenyl acetate 33189-72-9 ##### 5039 Pheromone Pheromone
    trans-6-Nonen-1-ol NA 1404 NA 197 NA 197 Pheromone Pheromone
    Trimedlure 12002-53-8 ##### NA 199 Pheromone Pheromone
    Z-2-isopropenyl-1-methyl 26532-22-9 ##### 2190 Pheromone Pheromone
    cyclobutane ethanol
    Z-3,3-dimethyl-delta,alpha- NA 952 NA 316 2192 Pheromone Pheromone
    cyclohexane ethanal
    Z-3,3-dimethyl-delta,beta- NA 706 NA 129 2191 Pheromone Pheromone
    cyclohexane ethanol
    Z-8-dodecene NA 1531 NA 224 NA 224 Pheromone Pheromone
    Z-8-dodecenol 40642-40-8 ##### 2253 Pheromone Pheromone
    Z-8-dodecenyl acetate 28079-04-1 ##### 2251 Pheromone Pheromone
    7-(diethyl amino)-4-methyl 91-44-1 NA 341 3146 Rodenticide Coumarin
    coumarin
    Brodifacoum 56073-10-0 ##### 2049 Rodenticide Coumarin
    Bromadiolone 28772-56-7 ##### 2135 Rodenticide Coumarin
    Coumachlor 81-82-3 ##### NA 126 Rodenticide Coumarin
    Coumafuryl 117-52-2 86001 298 Rodenticide Coumarin
    Coumafuryl, sodium salt 34490-93-2 86004 299 Rodenticide Coumarin
    Coumarin 91-64-5 ##### NA 102 Rodenticide Coumarin
    Coumatetralyl 5836-29-3 ##### NA 153 Rodenticide Coumarin
    Difenacoum 56073-07-5 ##### NA 970 Rodenticide Coumarin
    Flocoumafen 90035-08-8 NA 182 NA 181 Rodenticide Coumarin
    Potassium warfarin 2610-86-8 86005 NA 836 Rodenticide Coumarin
    Pyranocoumarin NA 1431 NA 199 NA 199 Rodenticide Coumarin
    Warfarin 81-81-2 86002 621 Rodenticide Coumarin
    Warfarin, sodium salt 129-06-6 86003 1184 Rodenticide Coumarin
    2-isovaleryl 1-1,3-indandione 83-28-3 67702 1435 Rodenticide 1,3-Indandione
    2-isovaleryl 1-1,3-indandione, 23710-76-1 67706 1736 Rodenticide 1,3-Indandione
    calcium salt
    2-isovaleryl-1,3-indandione, 53404-57-2 67709 NA 596 Rodenticide 1,3-Indandione
    sodium salt
    Chlorophacinone 3691-35-8 67707 1625 Rodenticide 1,3-Indandione
    Diphacinone 82-66-6 67701 225 Rodenticide 1,3-Indandione
    Diphacinone, sodium salt 42721-99-3 67705 1636 Rodenticide 1,3-Indandione
    Pindone 83-26-1 67703 489 Rodenticide 1,3-Indandione
    Pindone, calcium salt 53404-72-1 67708 NA 595 Rodenticide 1,3-Indandione
    Pindone, sodium salt 6120-20-3 67704 1305 Rodenticide, 1,3-Indandione
    Bird Repellent
    4-Hydroxymethyl NA 1173 NA 177 NA 165 Breakdown 2,6-Dinitroaniline
    pendimethalin product
    Benfluralin 1861-40-1 84301 53 Herbicide 2,6-Dinitroaniline
    Butralin 33629-47-9 ##### 1756 Herbicide 2,6-Dinitroaniline
    Dinitramine 29091-05-2 ##### 1683 Herbicide 2,6-Dinitroaniline
    Dipropalin 5332 ##### NA 145 Herbicide 2,6-Dinitroaniline
    Ethalfluralin 55283-68-6 ##### 2166 Herbicide 2,6-Dinitroaniline
    Fluazinam 79622-59-6 ##### 3898 Fungicide 2,6-Dinitroaniline
    Fluchloralin 33245-39-5 ##### 1848 Herbicide 2,6-Dinitroaniline
    Flumetralin 62924-70-3 ##### 5085 Plant Growth 2,6-Dinitroaniline
    Regulator
    Isopropalin 33820-53-0 ##### 1681 Herbicide 2,6-Dinitroaniline
    N,N-Bis(2-chloroethyl)-4- 26389-78-6 ##### NA 135 N/A 2,6-Dinitroaniline
    methyl-2,6-dinitroaniline
    Nitralin 4726-14-1 37601 490 Herbicide 2,6-Dinitroaniline
    Oryzalin 19044-88-3 ##### 1868 Herbicide 2,6-Dinitroaniline
    Pendimethalin 40487-42-1 ##### 1929 Herbicide 2,6-Dinitroaniline
    Prodiamine 29091-21-2 ##### 2236 Herbicide 2,6-Dinitroaniline
    Prodiamine, other related NA 1149 NA 168 92236 Herbicide 2,6-Dinitroaniline
    Profluralin 26399-36-0 ##### 1897 Herbicide 2,6-Dinitroaniline
    Profluralin, other related NA 1141 NA 167 91897 Herbicide 2,6-Dinitroaniline
    Trifluralin 1582-09-8 36101 597 Herbicide 2,6-Dinitroaniline
    1-(3- 51971-67-6 ##### NA 110 N/A Carboxamide
    chlorophthalimido)cyclohexane
    carboxamide
    Allidochlor 93-71-0 19301 114 Herbicide Amide
    Allidochlor 202-270-7 NA 210 NA 210 Herbicide Amide
    Ammonium benzadox 5251-79-6 98201 NA 858 Herbicide Amide
    Beflubutamid 113614-08-7 NA 230 NA 230 Herbicide Amide
    Benzadox 5251-93-4 ##### NA 132 Herbicide Amide
    Benzipram 35256-86-1 ##### NA 133 Herbicide Amide
    Bromobutide 74712-19-9 NA 203 NA 203 Herbicide Amide
    Carboxin 5234-68-4 90201 1755 Fungicide Carboxamide
    Chlorthiamid 1918-13-4 ##### NA 139 Herbicide Amide
    Cisanilide 34484-77-0 ##### NA 144 Herbicide Carboxamide
    Cyclafuramide 34849-42-8 ##### NA 132 Fungicide Carboxamide
    Cyprazole 42089-03-2 ##### NA 132 Herbicide Amide
    Dimethenamid 87674-68-8 ##### 5112 Herbicide Amide
    Diphenamid 957-51-7 36601 226 Herbicide Amide
    Epronaz 59026-08-3 NA 231 NA 231 Herbicide Amide
    Etnipromid 76120-02-0 NA 231 NA 231 Herbicide Amide
    Fenfuram 24691-80-3 NA 188 NA 187 Fungicide Carboxamide
    Fentrazamide 158237-07-1 NA 232 NA 231 Herbicide Amide
    Flupoxam 119126-15-7 NA 188 NA 188 Herbicide Amide
    Furmecyclox (Xyligen B) 60568-05-0 ##### NA 18 Fungicide Carboxamide
    Halosafen 77227-69-1 NA 229 NA 229 Herbicide Amide, Nitrophenyl
    ether
    Isocarbamide 30979-48-7 NA 183 NA 182 Herbicide Amide
    Isoxaben 82558-50-7 ##### 2289 Herbicide Amide
    Methfuroxam 28730-17-8 ##### NA 949 Fungicide Carboxamide
    Metsulfovax 21452-18-6 NA 189 NA 188 Fungicide Carboxamide
    Napropamide 15299-99-7 ##### 1728 Herbicide Amide
    Naptalam 132-66-1 30702 2998 Herbicide Amide
    Naptalam, sodium salt 132-67-2 30703 437 Herbicide Amide
    Nitrofurazone (not subject to 59-87-0 ##### NA 128 N/A Carboxamide
    FIFRA: 8709-e pm 24)
    Oxycarboxin 5259-88-1 90202 1434 Fungicide Carboxamide
    p-Benzoquinone 61566-21-0 ##### NA 133 N/A Carboxamide
    semicarbazone
    Pethoxamid 106700-29-2 NA 233 NA 233 Herbicide Amide
    Propyzamide 23950-58-5 ##### 694 Herbicide Amide
    Propyzamide metabolite NA 1048 NA 155 4093 Breakdown Amide
    product
    Quinonamid 27541-88-4 NA 210 NA 209 Herbicide Amide
    2-Hydroxy alachlor NA 943 NA 183 2602 Breakdown Chloroacetanilide
    product
    3,4,5-tribromo salicylanilide, NA 1122 NA 165 90833 Microbiocide Anilide
    other related
    3,5-dibromosalicylanilide 2577-72-2 77405 1256 Microbiocide Anilide
    5,4-dibromosalicylanilide NA 1024 NA 122 1071 Microbiocide Anilide
    Aatram (propachlor with 8070-76-6 80816 NA 781 Herbicide Triazine,
    atrazine) (019101 + 080803) Chloroacetanilide
    Acetochlor 34256-82-1 ##### 2349 Herbicide Chloroacetanilide
    Alachlor 15972-60-8 90501 678 Herbicide Chloroacetanilide
    Benodanil 15310-01-7 ##### NA 154 Fungicide Anilide
    Butachlor 23184-66-9 ##### 4056 Herbicide Chloroacetanilide
    Butenachlor 87310-56-3 NA 206 NA 206 Herbicide Chloroacetanilide
    Clomeprop 84496-56-0 NA 204 NA 203 Herbicide Anilide
    Cyprofuram 69581-33-5 NA 186 NA 185 Fungicide Anilide
    Cypromid 2759-71-9 26101 178 Herbicide Anilide
    Delachlor 24353-58-0 ##### NA 132 Herbicide Chloroacetanilide
    Diethatyl-ethyl 38727-55-8 ##### 1995 Herbicide Chloroacetanilide
    Diflufenican 83164-33-4 NA 184 NA 183 Herbicide Anilide
    Dimethachlor 50563-36-5 NA 184 NA 183 Herbicide Chloroacetanilide
    Etobenzanid 79540-50-4 NA 229 NA 228 Herbicide Anilide
    Fenasulam 78357-48-9 NA 231 NA 231 Herbicide Anilide
    Flufenacet 142459-58-3 ##### 5293 Herbicide Anilide
    Flufenican NA 1568 NA 234 NA 234 Herbicide Anilide
    Flutolanil 66332-96-5 ##### 2305 Fungicide Anilide
    Mefenacet 73250-68-7 NA 189 NA 188 Herbicide Anilide
    Mefluidide 53780-34-0 ##### 5082 Herbicide, Anilide
    Plant Growth
    Regulator
    Mefluidide, diethanolamine salt 53780-36-2 ##### 1955 Herbicide Anilide
    Mefluidide, potassium salt 83601-83-6 ##### 5083 Herbicide Anilide
    Mepronil 55814-41-0 NA 189 NA 188 Fungicide Anilide
    Metazachlor 67129-08-2 NA 184 NA 183 Herbicide Chloroacetanilide
    Metolachlor 51218-45-2 ##### 1996 Herbicide Chloroacetanilide
    Metolachlor, (S) 87392-12-9 ##### 5133 Herbicide Chloroacetanilide
    Monalide 7287-36-7 ##### NA 134 Herbicide Anilide
    Naproanilide 52570-16-8 NA 233 NA 232 Herbicide Anilide
    Ofurace 58810-48-3 NA 189 NA 188 Fungicide Anilide
    Oxadixyl 77732-09-3 ##### 3539 Fungicide Anilide
    Perfluidone 37924-13-3 ##### 1895 Herbicide Anilide
    Perfluidone, diethanolamine NA 991 NA 671 1896 Herbicide Anilide
    salt
    Pretilachlor 51218-49-6 NA 184 NA 184 Herbicide Chloroacetanilide
    Propachlor 1918-16-7 19101 511 Herbicide Chloroacetanilide
    Propanil 709-98-8 28201 503 Herbicide Anilide
    Propisochlor 86763-47-5 NA 233 NA 233 Herbicide Chloroacetanilide
    Prynachlor 21267-72-1 ##### NA 138 Herbicide, Chloroacetanilide
    Plant Growth
    Regulator
    Pyracarbolid 24691-76-7 NA 210 NA 209 Fungicide Anilide
    Salicylanilide 87-17-2 77407 450 Fungicide, Anilide
    Microbiocide
    Sodium salicylanilide 251930 ##### NA 145 Fungicide Anilide
    Thenylchlor 96491-05-3 NA 229 NA 229 Herbicide Chloroacetanilide
    Triclocarban 101-20-2 27901 844 N/A Anilide
    Benzoylprop 22212-56-2 NA 182 NA 181 Herbicide Arylalanine
    Benzoylprop ethyl 22212-55-1 ##### NA 147 Herbicide Arylalanine
    Benzoylprop-ethyl 33878-50-1 NA 206 NA 205 Herbicide Arylalanine
    Flamprop 58667-63-3 NA 188 NA 187 Herbicide Arylalanine
    Flamprop-isopropyl 52756-22-6 ##### NA 154 Herbicide Arylalanine
    Flamprop-M-isopropyl 57973-67-8 ##### NA 154 Herbicide Arylalanine
    Flamprop-M-methyl 57973-66-7 ##### NA 104 Herbicide Arylalanine
    Flamprop-methyl 52756-25-9 ##### NA 154 Herbicide Arylalanine
    Chlorazifop 60074-25-1 NA 231 NA 230 Herbicide Aryloxyphenoxy
    propionic acid
    Clodinafop 114420-56-3 NA 182 NA 182 Plant Growth Aryloxyphenoxy
    Regulator propionic acid
    Clodinafop-propargyl 105512-06-9 ##### NA 163 Plant Growth Aryloxyphenoxy
    Regulator propionic acid
    Clofop 26129-32-8 NA 207 NA 206 Herbicide Aryloxyphenoxy
    propionic acid
    Cyhalofop 122008-78-0 NA 204 NA 203 Herbicide Aryloxyphenoxy
    propionic acid
    Cyhalofop butyl 122008-85-9 NA 215 5748 Herbicide Aryloxyphenoxy
    propionic acid
    Diclofop 40843-25-2 ##### NA 912 Herbicide Aryloxyphenoxy
    propionic acid
    Diclofop-methyl 51338-27-3 ##### 2034 Herbicide Aryloxyphenoxy
    propionic acid
    Fenoxaprop-ethyl 82110-72-3 NA 201 NA 200 Herbicide Aryloxyphenoxy
    (stereochemistry unspecified) propionic acid
    Fenoxaprop-P (+) 71283-80-2 ##### 5123 Herbicide Aryloxyphenoxy
    propionic acid
    Fenoxaprop-P (+/−) 66441-23-4 ##### 2311 Herbicide Aryloxyphenoxy
    propionic acid
    Fenoxaprop-P-ethyl 113158-40-0 NA 220 NA 219 Herbicide Aryloxyphenoxy
    propionic acid
    Fenthiaprop (racemic) 95721-12-3 NA 207 NA 207 Herbicide Aryloxyphenoxy
    propionic acid
    Fenthiaprop (unstated 73519-50-3 NA 218 NA 217 Herbicide Aryloxyphenoxy
    stereochemistry) propionic acid
    Fenthiaprop-ethyl (racemic) 93921-16-5 NA 218 NA 217 Herbicide Aryloxyphenoxy
    propionic acid
    Fenthiaprop-ethyl (unstated 66441-11-0 NA 218 NA 217 Herbicide Aryloxyphenoxy
    stereochemistry) propionic acid
    Fluazifop 69335-91-7 NA 194 NA 193 Herbicide Aryloxyphenoxy
    propionic acid
    Fluazifop-butyl 69806-50-4 ##### 2186 Herbicide Aryloxyphenoxy
    propionic acid
    Fluazifop-P-butyl 79241-46-6 ##### NA 995 Herbicide Aryloxyphenoxy
    propionic acid
    Fluazifop-P-butyl 83066-88-0 NA 228 NA 228 Herbicide Aryloxyphenoxy
    propionic acid
    Haloxyfop (unstated 69806-34-4 ##### NA 100 Herbicide Aryloxyphenoxy
    stereochemistry) propionic acid
    Haloxyfop-etotyl (unstated 87237-48-7 NA 200 NA 199 Herbicide Aryloxyphenoxy
    stereochemistry) propionic acid,
    Glycol Ether
    Haloxyfop-methyl (unstated 690806-40-2 ##### NA 19 Herbicide Aryloxyphenoxy
    stereochemistry) propionic acid
    Haloxyfop-R 72619-32-0 NA 191 NA 190 Herbicide Aryloxyphenoxy
    propionic acid
    Propaquizafop 111479-05-1 NA 185 NA 184 Herbicide Aryloxyphenoxy
    propionic acid
    Quizalofop 76578-12-6 NA 190 NA 189 Herbicide Aryloxyphenoxy
    propionic acid
    Quizalofop-ethyl 76578-14-8 ##### 2226 Herbicide Aryloxyphenoxy
    propionic acid
    Quizalofop-P 94051-08-8 NA 185 NA 184 Herbicide Aryloxyphenoxy
    propionic acid
    Quizalofop-P-ethyl 100646-51-3 NA 212 NA 211 Herbicide Aryloxyphenoxy
    propionic acid
    Quizalofop-p-tefuryl 119738-06-6 NA 202 NA 202 Herbicide Aryloxyphenoxy
    propionic acid
    Trifop 58594-744 NA 234 NA 233 Herbicide Aryloxyphenoxy
    propionic acid
    2,5-Dichlorobenzoic acid 50-79-3 NA 224 NA 224 Fungicide Benzoic acid
    2,5-Dichlorobenzoic acid 2905-69-3 NA 224 NA 224 Fungicide Benzoic acid
    methyl ester
    3,5-dichlorobenzoic acid 51-36-5 NA 156 4066 N/A Benzoic acid
    4′-hydroxy-m-phenoxy benzoic 35065-12-4 NA 176 2609 Fungicide, Benzoic acid
    acid Microbiocide
    4-hydroxy benzoic acid 99-96-7 NA 200 NA 199 N/A Benzoic acid
    5-hydroxy-dicamba NA 840 NA 156 4065 Herbicide, Benzoic acid
    Breakdown
    product
    Butyl paraben 94-26-8 61205 NA 496 Fungicide, Benzoic acid
    Microbiocide
    Chloramben 133-90-4 29901 2184 Herbicide Benzoic acid
    Chloramben, ammonium salt 1076-46-6 29902 831 Herbicide Benzoic acid
    Chloramben, ammonium salt, NA 1121 NA 165 90831 Herbicide Benzoic acid
    other related
    Dicamba 1918-00-9 29801 200 Herbicide Benzoic acid
    Dicamba with 2,4-D 8068-77-7 29807 NA 219 Herbicide Benzoic acid
    Dicamba with 2,4-D & Silvex 8073-53-8 29808 NA 220 Herbicide Benzoic acid
    Dicamba, aluminium salt NA 1215 ##### NA 170 Herbicide Benzoic acid
    Dicamba, butoxyethyl ester NA 1477 NA 220 NA 219 Herbicide Benzoic acid
    Dicamba, diethanolamine salt 25059-78-3 29803 780 Herbicide Benzoic acid
    Dicamba, diglycolamine salt 104040-79-1 ##### 5007 Herbicide Benzoic acid
    Dicamba, dimethylamine salt 2300-66-5 29802 849 Herbicide Benzoic acid
    Dicamba, dimethylamine salt, NA 1123 NA 165 90849 Herbicide Benzoic acid
    other related
    Dicamba, isopropylamine salt 55871-02-8 ##### 5098 Herbicide Benzoic acid
    Dicamba, methyl ester 6597-78-0 ##### NA 146 Herbicide Benzoic acid
    Dicamba, monoethanolamine 53404-28-7 29804 1829 Herbicide Benzoic acid
    salt
    Dicamba, monoethanolamine NA 1140 NA 167 91829 Herbicide Benzoic acid
    salt, other related
    Dicamba, other related NA 1084 NA 161 90200 Herbicide Benzoic acid
    Dicamba, potassium salt 10007-85-9 ##### 5110 Herbicide Benzoic acid
    Dicamba, sodium salt 1982-69-0 29806 5057 Herbicide Benzoic acid
    Dicamba, triethanolamine salt 53404-29-8 29805 1113 Herbicide Benzoic acid
    Dichlorobenzoic acid NA 1383 NA 195 NA 194 Fungicide Benzoic acid
    methylester
    Diethanolamine 3-amino-2,5- 53404-16-3 29904 NA 222 Herbicide Benzoic acid
    dichlorobenzoate
    Dodecylamine salicylate 7491-21-6 39302 2003 Insecticide, Benzoic acid
    Fungicide,
    Microbiocide
    Ethyl paraben 120-47-8 61202 3204 Fungicide, Benzoic acid
    Microbiocide
    Homosalate 118-56-9 76603 3231 Insecticide, Benzoic acid
    Fungicide,
    Microbiocide
    Methyl chloramben 7286-84-2 29905 NA 223 Herbicide Benzoic acid
    Methyl paraben 99-76-3 61201 1005 Fungicide, Benzoic acid
    Microbiocide
    Methyl paraben, calcium salt 40167-95-1 61208 NA 499 Fungicide, Benzoic acid
    Microbiocide
    Methyl paraben, sodium salt 5026-62-0 61207 NA 498 Fungicide, Benzoic acid
    Microbiocide
    Monomethylammonium 25182-03-0 29903 NA 221 Herbicide Benzoic acid
    chloramben (3-amino-2,5-
    dichlorobenzoic acid)
    Propyl paraben 94-13-3 61203 2841 Fungicide, Benzoic acid
    Microbiocide
    Propyl paraben, calcium salt 83542-69-2 61206 NA 497 Fungicide, Benzoic acid
    Microbiocide
    Propyl paraben, sodium salt 35285-69-9 61204 NA 495 Fungicide, Benzoic acid
    Microbiocide
    Salicylic acid 69-72-7 76602 1170 Insecticide, Benzoic acid
    Fungicide,
    Microbiocide
    Sodium 3-amino-2,5- 1954-81-0 29906 NA 224 Herbicide Benzoic acid
    dichlorobenzoate
    Tricamba 2307-49-5 17301 NA 151 Herbicide Benzoic acid
    Anisuron 2689-43-2 ##### NA 138 Herbicide Benzoylurea
    Diflubenzuron 35367-38-5 ##### 1992 Insecticide Benzoylurea
    Flucycloxuron 113036-88-7 ##### NA 109 Herbicide Benzoylurea
    Flucycloxuron, (E) 94050-52-9 NA 201 NA 200 Herbicide Benzoylurea
    Flufenoxuron 101463-69-8 ##### NA 901 Insecticide Benzoylurea
    Hexaflumuron 86479-06-3 ##### 3899 Insecticide Benzoylurea
    Lufenuron 103055-07-8 NA 184 NA 183 Insecticide Benzoylurea
    Novaluron 116714-46-6 NA 226 NA 226 Herbicide Benzoylurea
    Phenobenzuron 449583 ##### NA 133 Herbicide Benzoylurea
    Teflubenzuron 83121-18-0 ##### NA 33 Insecticide Benzoylurea
    Triflumuron 64628-44-0 ##### 2961 Insecticide Benzoylurea
    Diethamquat chloride NA 1567 NA 231 NA 231 Herbicide Bipyridylium
    Diquat bistribromide 27041-82-3 ##### NA 146 Herbicide Bipyridylium
    Diquat dibromide 85-00-7 32201 229 Herbicide, Bipyridylium
    Dessicant
    Diquat ion 2764-72-9 32202 NA 294 N/A Bipyridylium
    Monolinuron with paraquat 69312-67-0 ##### NA 119 Herbicide Urea, Bipyridylium
    dichloride
    Morfamquat 7411-47-4 ##### NA 135 N/A Bipyridylium
    Morfamquat 7411-47-4 NA 201 NA 200 Herbicide Bipyridylium
    Morfamquat chloride 4636-83-3 NA 212 NA 212 Herbicide Bipyridylium
    Paraquat 4685-14-7 61603 NA 500 Herbicide Bipyridylium
    Paraquat bis(methylsulfate) 2074-50-2 61602 458 Herbicide Bipyridylium
    Paraquat bistribromide 27041-84-5 ##### NA 159 Herbicide Bipyridylium
    Paraquat dichloride 1910-42-5 61601 1601 Herbicide Bipyridylium
    Priglone (diquat dibromide 78403-23-3 32203 NA 295 N/A Bipyridylium
    w/paraquat ion)
    1,3-Dimethyl-1,1,3,3- 22232-20-8 34601 NA 303 N/A Bis-Carbamate
    disiloxanetetrol-1,3-
    bis(dimethylthiocarbamate)
    Desmedipham 13684-56-5 ##### 1748 Herbicide Bis-Carbamate
    Dimethyl (4-methyl-1,3- 51543-98-7 ##### NA 888 Fungicide Bis-Carbamate
    phenylenebis(iminocarbonyl-
    1H-benzimidazole-1,2-
    diyl))biscarbamate
    Phenisopham 57375-63-0 NA 209 NA 208 Herbicide Bis-Carbamate
    Phenmedipham 13684-63-4 98701 675 Herbicide Bis-Carbamate
    Phenmedipham-ethyl 13684-44-1 ##### NA 149 Herbicide Bis-Carbamate
    2-Hydroxy alachlor NA 943 NA 183 2602 Breakdown Chloroacetanilide
    product
    Aatram (propachlor with 8070-76-6 80816 NA 781 Herbicide Triazine,
    atrazine) (019101 + 080803) Chloroacetanilide
    Acetochlor 34256-82-1 ##### 2349 Herbicide Chloroacetanilide
    Alachlor 15972-60-8 90501 678 Herbicide Chloroacetanilide
    Butachlor 23184-66-9 ##### 4056 Herbicide Chloroacetanilide
    Butenachlor 87310-56-3 NA 206 NA 206 Herbicide Chloroacetanilide
    Delachlor 24353-58-0 ##### NA 132 Herbicide Chloroacetanilide
    Diethatyl-ethyl 38727-55-8 ##### 1995 Herbicide Chloroacetanilide
    Dimethachlor 50563-36-5 NA 184 NA 183 Herbicide Chloroacetanilide
    Metazachlor 67129-08-2 NA 184 NA 183 Herbicide Chloroacetanilide
    Metolachlor 51218-45-2 ##### 1996 Herbicide Chloroacetanilide
    Metolachlor, (S) 87392-12-9 ##### 5133 Herbicide Chloroacetanilide
    Pretilachlor 51218-49-6 NA 184 NA 184 Herbicide Chloroacetanilide
    Propachlor 1918-16-7 19101 511 Herbicide Chloroacetanilide
    Propisochlor 86763-47-5 NA 233 NA 233 Herbicide Chloroacetanilide
    Prynachlor 21267-72-1 ##### NA 138 Herbicide, Chloroacetanilide
    Plant Growth
    Regulator
    Thenylchlor 96491-05-3 NA 229 NA 229 Herbicide Chloroacetanilide
    (2-Methyl-4,6- 13333-87-4 ##### NA 161 Impurity Chlorophenoxy acid
    dichlorophenoxy)acetic acid or ester
    (as impurity)
    2,3,6-Trichlorophenylacetic 2903-64-2 82603 NA 819 Herbicide Chlorophenoxy acid
    acid or ester
    2,3,6-Trichlorophenylacetic 53404-91-4 82604 NA 820 Herbicide Chlorophenoxy acid
    acid, sodium salt or ester
    2,4,5-T 93-76-5 82001 639 Herbicide Chlorophenoxy acid
    or ester
    2,4,5-T tetradecylamine salt 53535-37-8 82013 1989 Herbicide Chlorophenoxy acid
    or ester
    2,4,5-T, 2-ethylhexyl ester 1928-47-8 82063 1092 Herbicide Chlorophenoxy acid
    or ester
    2,4,5-T, alkylamine salt 53535-37-8 82013 818 Herbicide Chlorophenoxy acid
    or ester
    2,4,5-T, butoxyethanol ester 2545-59-7 82053 819 Herbicide Chlorophenoxy acid
    or ester, Glycol Ether
    2,4,5-T, butoxyethanol ester 2545-59-7 82072 NA 166 Herbicide Chlorophenoxy acid
    or ester
    2,4,5-T, butoxypropyl ester 1928-48-9 82055 820 Herbicide Chlorophenoxy acid
    or ester
    2,4,5-T, butyl ester 93-79-8 82056 822 Herbicide Chlorophenoxy acid
    or ester
    2,4,5-T, butyric acid 93-80-1 ##### NA 152 Herbicide Chlorophenoxy acid
    or ester
    2,4,5-T, dimethylamine salt 6369-97-7 82019 1474 Herbicide Chlorophenoxy acid
    or ester
    2,4,5-T, dodecylamine salt 53404-84-5 82011 1988 Herbicide Chlorophenoxy acid
    or ester
    2,4,5-T, isooctyl ester 25168-15-4 NA 121 851 Herbicide Chlorophenoxy acid
    or ester
    2,4,5-T, N-oleyl-1,3- 53404-87-8 82029 1097 Herbicide Chlorophenoxy acid
    propylenediamine salt or ester
    2,4,5-T, propylene glycol butyl 1928-48-9 82055 824 Herbicide Chlorophenoxy acid
    ether ester or ester
    2,4,5-T, triethylamine salt 2008-46-0 82034 850 Herbicide Chlorophenoxy acid
    or ester
    2,4,5-trichlorophenoxyacetic 69462-12-0 82064 NA 799 Herbicide Chlorophenoxy acid
    acid, 2-ethyl-4-methylpentyl or ester
    ester
    2,4,5-trichlorophenoxyacetic 53404-85-6 82012 NA 790 Herbicide Chlorophenoxy acid
    acid, alkyl(C13) amine salt or ester
    2,4,5-trichlorophenoxyacetic 120-39-8 82051 NA 795 Herbicide Chlorophenoxy acid
    acid, amyl ester or ester
    2,4,5-trichlorophenoxyacetic 1928-58-1 82052 NA 796 Herbicide Chlorophenoxy acid
    acid, butoxyethoxypropanol or ester
    ester
    2,4,5-trichlorophenoxyacetic 53404-86-7 82038 NA 793 Herbicide Chlorophenoxy acid
    acid, diethylethanolamine salt or ester
    2,4,5-trichlorophenoxyacetic 4938-72-1 82062 NA 798 Herbicide Chlorophenoxy acid
    acid, isobutyl ester or ester
    2,4,5-trichlorophenoxyacetic 93-78-7 82066 NA 800 Herbicide Chlorophenoxy acid
    acid, isopropyl ester or ester
    2,4,5-trichlorophenoxyacetic 55256-33-2 82039 NA 794 Herbicide Chlorophenoxy acid
    acid, N,N-dimethyl oleyl- or ester
    linoleyl amine salt
    2,4,5-trichlorophenoxyacetic 53404-88-9 82037 NA 792 Herbicide Chlorophenoxy acid
    acid, N,N- or ester
    dimethyllinoleylamine salt
    2,4,5-trichlorophenoxyacetic 53404-89-0 82020 NA 791 Herbicide Chlorophenoxy acid
    acid, N,N-dimethyloleylamine or ester
    salt
    2,4,5-trichlorophenoxyacetic 55491-33-3 82077 NA 803 Herbicide Chlorophenoxy acid
    acid, pentyl ester or ester
    2,4,5-trichlorophenoxyacetic 13560-99-1 82004 NA 789 Herbicide Chlorophenoxy acid
    acid, sodium salt or ester
    2,4,5-trichlorophenoxyacetic 53535-32-3 82075 NA 802 Herbicide Chlorophenoxy acid
    acid, tripropylene glycol or ester
    isobutyl ether ester
    2,4-D 94-75-7 30001 636 Herbicide, Chlorophenoxy acid
    Plant Growth or ester
    Regulator
    2,4-D with 2,4,5-T 8015-35-8 30077 NA 259 Herbicide Chlorophenoxy acid
    or ester
    2,4-D, 2-ethyl-4-methylpentyl 53404-37-8 NA 227 NA 227 Herbicide Chlorophenoxy acid
    ester or ester
    2,4-D, 2-ethylhexyl ester 1928-43-4 30063 1622 Herbicide Chlorophenoxy acid
    or ester
    2,4-D, alkanolamine salts 2307-55-3 30005 801 Herbicide Chlorophenoxy acid
    (ethanol and isopropanol or ester
    amines)
    2,4-D, alkyl (C12) amine salts 2212-54-6 30011 980 Herbicide Chlorophenoxy acid
    or ester
    2,4-D, alkyl (C14) amine salts 28685-18-9 30013 981 Herbicide Chlorophenoxy acid
    or ester
    2,4-D, butoxy ethoxy propanol 1928-57-0 30052 1255 Herbicide Chlorophenoxy acid
    ester or ester
    2,4-D, butoxyethanol ester 1929-73-3 30053 802 Herbicide Chlorophenoxy acid
    or ester, Glycol Ether
    2,4-D, butoxyethanol ester 1929-73-3 30061 NA 166 Herbicide Chlorophenoxy acid
    or ester
    2,4-D, butoxypropyl ester 1928-45-6 30055 803 Herbicide Chlorophenoxy acid
    or ester
    2,4-D, butyl ester 94-80-4 30056 804 Herbicide Chlorophenoxy acid
    or ester
    2,4-D, chlorocrotyl ester 2971-38-2 NA 228 NA 227 Herbicide Chlorophenoxy acid
    or ester
    2,4-D, diethanolamine salt 5742-19-8 30016 805 Herbicide Chlorophenoxy acid
    or ester
    2,4-D, diethylamine salt 20940-37-8 30017 875 Herbicide Chlorophenoxy acid
    or ester
    2,4-D, dimethylamine salt 2008-39-1 30019 806 Herbicide Chlorophenoxy acid
    or ester
    2,4-D, dodecylamine salt 2212-54-6 30011 807 Herbicide Chlorophenoxy acid
    or ester
    2,4-D, heptylamine salt 37102-63-9 30023 1962 Herbicide Chlorophenoxy acid
    or ester
    2,4-D, isooctyl ester 25168-26-7 30064 809 Herbicide Chlorophenoxy acid
    or ester
    Triclopyr 55335-06-3 ##### NA 36 Herbicide Chloropyridinyl
    Triclopyr ethyl ester 60825-27-6 ##### NA 108 Herbicide Chloropyridinyl
    Triclopyr, butoxyethyl ester 64700-56-7 ##### 2170 Herbicide Chloropyridinyl,
    Glycol Ether
    Triclopyr, triethylamine salt 57213-69-1 ##### 2131 Herbicide Chloropyridinyl
    Alloxydim 55634-91-8 NA 203 NA 203 Herbicide Cyclohexenone
    derivative
    Alloxydim sodium 55635-13-7 ##### NA 926 Herbicide Cyclohexenone
    derivative
    Butroxydim 138164-12-2 NA 202 NA 202 Herbicide Cyclohexenone
    derivative
    Clethodim 99129-21-2 ##### 3566 Herbicide Cyclohexenone
    derivative
    Cloproxydim 95480-33-4 NA 231 NA 231 Herbicide Cyclohexenone
    derivative
    Cycloxydim 101205-02-1 NA 184 NA 183 Herbicide Cyclohexenone
    derivative
    Sethoxydim 74051-80-2 ##### 2177 Herbicide Cyclohexenone
    derivative
    Tepraloxydim 149979-41-9 ##### NA 982 Herbicide Cyclohexenone
    derivative
    Tralkoxydim 87820-88-0 ##### 5457 Herbicide Cyclohexenone
    derivative
    2,4-dinitrophenol 51-28-5 37509 221 Impurity Dinitrophenol
    derivative
    2,4-dinitrophenol, sodium salt 1011-73-0 ##### NA 161 Impurity, Dinitrophenol
    (as impurity) Breakdown derivative
    product
    2,4-Dinitrophenyl thiocyanate 1594-56-5 ##### NA 146 N/A Dinitrophenol
    derivative
    2,6-dinitrophenol, sodium salt 32581-06-9 ##### NA 161 Impurity Dinitrophenol
    (as impurity) derivative
    2-Cyclohexyl-4,6-dinitrophenol 317-83-9 37502 NA 316 N/A Dinitrophenol
    dicyclohexylamine derivative
    3,3′-Dichloro-5,5′-dinitro-(1,1′- 15595-24-1 ##### NA 137 N/A Dinitrophenol
    biphenyl)-2,2′-diol derivative
    3,3′-Dichloro-5,5′-dinitro-(1,1′- 63992-31-4 ##### NA 137 N/A Dinitrophenol
    biphenyl)-2,2′-diol derivative
    4,6-Dinitro-2- 69632-97-9 ##### NA 145 N/A Dinitrophenol
    cyclohexylphenol, 2-((2- derivative
    aminoethyl)amino)ethanol salt
    4,6-Dinitro-2- 69632-98-0 ##### NA 145 N/A Dinitrophenol
    cyclohexylphenol, derivative
    triethanolamine salt
    5,5′-Dichloro-3,3′-dinitro-(1,1′- 10331-57-4 ##### NA 137 N/A Dinitrophenol
    biphenyl)-2,2′-diol derivative
    6,6′-Dichloro-4,4′-dinitro-(1,1′- 21832-25-7 ##### NA 137 N/A Dinitrophenol
    biphenyl)-2,2′-diol derivative
    Binapacryl 485-31-4 12201 73 Herbicide Dinitrophenol
    derivative
    Diethanolamine dinoseb (2- 53404-43-6 37514 NA 320 Herbicide Dinitrophenol
    sec-butyl-4,6-dinitrophenol) derivative
    Dinex 131-89-5 37501 NA 315 N/A Dinitrophenol
    derivative
    Dinitro cresol 534-52-1 37507 3170 Fungicide Dinitrophenol
    derivative
    Dinitro-1-methyl heptyl phenol NA 159 NA 302 758 N/A Dinitrophenol
    derivative
    Dinitrophenol (mixed isomers) 25550-58-7 NA 223 NA 223 Breakdown Dinitrophenol
    product, derivative
    Impurity
    Dinobuton 973-21-7 ##### 2526 Insecticide, Dinitrophenol
    Fungicide derivative
    Dinocap 39300-45-3 36001 344 Fungicide, Dinitrophenol
    Insecticide derivative
    Dinocap, other related NA 1091 NA 162 90344 Insecticide, Dinitrophenol
    Fungicide derivative
    Dinocton 32534-96-6 NA 207 NA 206 Insecticide, Dinitrophenol
    Fungicide derivative
    Dinofenate 61614-62-8 ##### NA 146 Herbicide Dinitrophenol
    derivative
    Dinopenton 5386-57-2 ##### NA 154 N/A Dinitrophenol
    derivative
    Dinoprop 7257-41-2 ##### NA 138 N/A Dinitrophenol
    derivative
    Dinosam 4097-36-3 37504 NA 318 N/A Dinitrophenol
    derivative
    Dinoseb 88-85-7 37505 238 Herbicide, Dinitrophenol
    Defoliant derivative
    Dinoseb acetate 2813-95-8 NA 207 NA 206 Herbicide Dinitrophenol
    derivative
    Dinoseb, amine salt 2244387 37511 239 Herbicide, Dinitrophenol
    Defoliant derivative
    Dinoseb, ammonium salt 6365-83-9 37513 240 Herbicide, Dinitrophenol
    Defoliant derivative
    Dinoseb, sodium salt 35040-03-0 37512 1445 Herbicide, Dinitrophenol
    Defoliant derivative
    Dinoseb, triethanolamine salt 6420-47-9 37506 235 Herbicide, Dinitrophenol
    Defoliant derivative
    Dinosulfon 5386-77-6 ##### NA 157 N/A Dinitrophenol
    derivative
    Dinoterb 1420-07-1 ##### NA 128 Herbicide Dinitrophenol
    derivative
    Dinoterbon 6073-72-9 ##### NA 128 Herbicide Dinitrophenol
    derivative
    DNOC, sodium salt 2312-76-7 37508 533 Fungicide, Dinitrophenol
    Microbiocide, derivative
    Insecticide,
    Herbicide
    Etinofen 2544-94-7 ##### NA 147 N/A Dinitrophenol
    derivative
    Medinoterb acetate 212943 NA 208 NA 208 Herbicide Dinitrophenol
    derivative
    Methyl 2-(1-methylheptyl)-4,6- 5386-68-5 ##### NA 157 N/A Dinitrophenol
    dinitrophenyl carbonate derivative
    Premerge plus (naptalam with 8075-57-8 30704 NA 278 Herbicide Dinitrophenol
    dinoseb) derivative
    Sodium naptalam with sodium 59915-53-6 30705 NA 279 Herbicide Dinitrophenol
    dinoseb derivative
    Sultropen 963-22-4 ##### NA 146 N/A Dinitrophenol
    derivative
    Acifluorfen 50594-66-6 ##### NA 935 Herbicide Diphenyl ether
    Acifluorfen, sodium salt 62476-59-9 ##### 2218 Herbicide Diphenyl ether
    Aclonifen 74070-46-5 NA 187 NA 187 Herbicide Diphenyl ether
    Bifenox 42576-02-3 ##### 1953 Herbicide Diphenyl ether
    Chlomethoxyfen 32861-85-1 NA 185 NA 185 Herbicide Diphenyl ether
    Diofenolan 63837-33-2 7703 NA 101 Herbicide Diphenyl ether
    Ethyl acifluorfen 77207-01-3 ##### NA 936 Herbicide Diphenyl ether
    Fluoroglycofen 77501-60-1 NA 181 NA 180 Herbicide Diphenyl ether
    Fomesafen 72178-02-0 ##### NA 17 Herbicide Diphenyl ether
    Fomesafen sodium 108731-70-0 ##### 5086 Herbicide Diphenyl ether
    Lactofen 77501-63-4 ##### 3538 Herbicide Diphenyl ether
    Methyl acifluorfen 50594-67-7 ##### NA 937 Herbicide Diphenyl ether
    Oxyfluorfen 42874-03-3 ##### 1973 Herbicide Diphenyl ether
    Bromobonil 25671-46-9 ##### NA 134 Herbicide Hydroxybenzonitrile
    Bromoxynil butyrate 3861-41-4 35303 2163 Herbicide Hydroxybenzonitrile
    Bromoxynil heptanoate 56634-95-8 ##### 5036 Herbicide Hydroxybenzonitrile
    Bromoxynil octanoate 1689-99-2 35302 834 Herbicide Hydroxybenzonitrile
    Bromoxynil pentanoate NA 1476 NA 220 NA 219 Herbicide Hydroxybenzonitrile
    Bromoxynil phenol 1689-84-5 35301 2429 Herbicide Hydroxybenzonitrile
    Chloroxynil 1891-95-8 ##### NA 138 Herbicide Hydroxybenzonitrile
    Ioxynil 1689-83-4 ##### 2616 Herbicide Hydroxybenzonitrile
    Ioxynil lithium 2961-61-7 ##### NA 141 Herbicide Hydroxybenzonitrile
    Ioxynil octanoate 3861-47-0 ##### NA 141 Herbicide Hydroxybenzonitrile
    Ioxynil sodium 2961-62-8 ##### NA 141 Herbicide Hydroxybenzonitrile
    3-5-(1,1-Dimethylethyl)-3- 78327-32-9 ##### NA 108 Algaecide Imidazolinone
    isoxazolyl-4-hydroxy-1-
    methyl-2-imidazolidinone
    3-Pyridinecarboxylic acid, 2- 81334-60-3 ##### NA 1 Herbicide Imidazolinone
    (4,5-dihydro-4-methyl-4-(1-
    methylethyl)-5-oxo-1H-
    imidazol-2-yl)-5-methyl-, (.+−.)-
    Imazamethabenz 81405-85-8 ##### 2240 Herbicide Imidazolinone
    Imazamox 114311-32-9 ##### NA 2 Herbicide Imidazolinone
    Imazapic 104098-48-8 NA 212 NA 211 Herbicide Imidazolinone
    Imazapyr 81334-34-1 ##### 2256 Herbicide Imidazolinone
    Imazapyr, isopropylamine salt 81510-83-0 ##### 2257 Herbicide Imidazolinone
    Imazaquin 81335-37-7 ##### 2613 Herbicide, Imidazolinone
    Plant Growth
    Regulator
    Imazaquin, ammonium salt 81335-47-9 ##### 3006 Herbicide Imidazolinone
    Imazaquin, sodium salt 81335-46-8 ##### 5109 Herbicide Imidazolinone
    Imazethapyr 81335-77-5 ##### 2340 Herbicide, Imidazolinone
    Plant Growth
    Regulator
    Imazethapyr, ammonium salt 101917-66-2 ##### 2341 Herbicide Imidazolinone
    Pyridine carboxylic acid, 2- 104098-49-9 ##### 5097 Herbicide Imidazolinone
    (4,5-dihydro-4-methyl-4-(1-
    methylethyl)-5-oxo-1H-
    imidazol-2-yl)-5-methyl,
    monoammonium salt
    Chloreturon 20782-58-5 NA 231 NA 230 Herbicide Phenylurea
    Daimuron 42609-52-9 NA 204 NA 204 Herbicide Phenylurea
    Fluothiuron 33439-45-1 NA 232 NA 232 Herbicide Phenylurea
    Methyldymron 42609-73-4 NA 205 NA 204 Herbicide Phenylurea
    Tetrafluoron 27954-37-6 ##### NA 145 Herbicide Phenylurea
    Bilanafos 71048-99-2 NA 202 NA 201 Herbicide Phosphinico amino
    acid
    Ampropylofos 16606-64-7 NA 181 NA 180 Fungicide Phosphonic acid
    Glyphosate 1071-83-6 ##### 2997 Herbicide Phosphonoglycine
    Glyphosate, ammonium salt 114370-14-8 NA 228 2319 Herbicide Phosphonoglycine
    Glyphosate, diammonium salt NA 1566 NA 229 5810 Herbicide Phosphonoglycine
    Glyphosate, isopropylamine 38641-94-0 ##### 1855 Herbicide Phosphonoglycine
    salt
    Glyphosate, monoammonium 114370-14-8 ##### 2301 Herbicide Phosphonoglycine
    salt
    Glyphosate, sodium sesqui salt 70393-85-0 ##### 2275 Herbicide Phosphonoglycine
    Glyphosate-trimesium 81591-81-3 ##### 2327 Herbicide Phosphonoglycine
    N,N- 2439-99-8 ##### NA 884 Herbicide Phosphonoglycine
    Bis(phosphonomethyl)glycine
    6-chloropicolinic acid 4684-94-0 69206 NA 657 Herbicide Pyridinecarboxylic
    acid
    Clopyralid 1702-17-6 ##### 5135 Herbicide Pyridinecarboxylic
    acid
    Clopyralid copper NA 1458 NA 216 NA 216 Herbicide Pyridinecarboxylic
    acid
    Clopyralid, monoethanolamine 57754-85-5 ##### 5050 Herbicide Pyridinecarboxylic
    salt acid
    Clopyralid, triethylamine salt NA 955 ##### 2339 Herbicide Pyridinecarboxylic
    acid
    Picloram 5145 5101 593 Herbicide Pyridinecarboxylic
    acid
    Picloram, alkanolamine salt NA 1479 NA 220 NA 219 Herbicide Pyridinecarboxylic
    acid
    Picloram, diethanolamine salt 5145 NA 220 NA 220 Herbicide Pyridinecarboxylic
    acid
    Picloram, isooctyl ester 26952-20-5 5103 835 Herbicide Pyridinecarboxylic
    acid
    Picloram, potassium salt 2545-60-0 5104 5330 Herbicide Pyridinecarboxylic
    acid
    Picloram, triethylamine salt 35832-11-2 5105 NA 77 Herbicide Pyridinecarboxylic
    acid
    Picloram, triisopropanolamine 6753-47-5 5102 1099 Herbicide Pyridinecarboxylic
    salt acid
    Picolinafen 137641-05-5 NA 210 NA 210 Herbicide Pyridinecarboxylic
    acid
    Thiazopyr 117718-60-2 ##### 3984 Herbicide Pyridinecarboxylic
    acid
    Amidosulfuron 120923-37-7 NA 183 NA 183 Herbicide Sulfonylurea
    Azimsulfuron 120162-55-2 ##### NA 112 Herbicide Sulfonylurea
    Bensulfuron 99283-01-9 NA 181 NA 180 Herbicide Sulfonylurea
    Bensulfuron methyl 83055-99-6 ##### 2263 Herbicide Sulfonylurea
    Chlorimuron 99283-00-8 NA 204 NA 203 Herbicide Sulfonylurea
    Chlorimuron ethyl 90982-32-4 ##### 2458 Herbicide Sulfonylurea
    Chlorsulfuron 64902-72-3 ##### 2143 Herbicide Sulfonylurea
    Cinosulfuron 94593-91-6 NA 183 NA 183 Herbicide Sulfonylurea
    Cyclosulfamuron 136849-15-5 NA 204 NA 203 Herbicide Sulfonylurea
    Ethametsulfuron 111353-84-5 NA 212 NA 212 Herbicide Sulfonylurea
    Ethametsulfuron-methyl 97780-06-8 ##### NA 43 Herbicide Sulfonylurea
    Ethoxysulfuron 126801-58-9 NA 226 NA 225 Herbicide Sulfonylurea
    Flazasulfuron 104040-78-0 NA 229 NA 228 Herbicide Sulfonylurea
    Flupyrsulfuron 150315-10-9 NA 205 NA 204 Herbicide Sulfonylurea
    Flupyrsulfuron-methyl NA 1460 NA 216 NA 216 Herbicide Sulfonylurea
    Flupyrsulfuron-methyl, sodium 144740-54-5 NA 218 NA 217 Herbicide Sulfonylurea
    salt
    Halosulfuron 100784-20-1 ##### 3919 Herbicide Sulfonylurea
    Imazosulfuron 122548-33-8 NA 229 NA 229 Herbicide Sulfonylurea
    Iodosulfuron methyl 185119-76-0 NA 212 NA 211 Herbicide Sulfonylurea
    Iodosulfuron methyl, sodium 144550-36-7 NA 212 NA 211 Herbicide Sulfonylurea
    salt
    Mesosulfuron-methyl 208465-21-8 ##### NA 993 Herbicide Sulfonylurea
    Metsulfuron 5585-64-8 NA 183 NA 182 Herbicide Sulfonylurea
    Metsulfuron-methyl 74223-64-6 ##### 2222 Herbicide Sulfonylurea
    Nicosulfuron 111991-09-4 ##### 3829 Herbicide Sulfonylurea
    Oxasulfuron 144651-06-9 ##### NA 991 Herbicide Sulfonylurea
    Primisulfuron-methyl 86209-51-0 ##### 5103 Herbicide Sulfonylurea
    Prosulfuron 94125-34-5 ##### 5115 Herbicide Sulfonylurea
    Pyrazosulfuron 98389-04-9 NA 205 NA 205 Herbicide Sulfonylurea
    Pyrazosulfuron-ethyl 93697-74-6 NA 218 NA 217 Herbicide Sulfonylurea
    Rimsulfuron 122931-48-0 ##### 3835 Herbicide Sulfonylurea
    Sulfometuron 74223-56-6 NA 206 NA 205 Herbicide Sulfonylurea
    Sulfometuron methyl 74222-97-2 ##### 2149 Herbicide Sulfonylurea
    Sulfosulfuron 141776-32-1 85601 5136 Herbicide Sulfonylurea
    Thifensulfuron 79277-67-1 NA 183 NA 182 Herbicide Sulfonylurea
    Thifensulfuron-methyl 79277-27-3 ##### 2237 Herbicide Sulfonylurea
    Triasulfuron 82097-50-5 ##### 5100 Herbicide Sulfonylurea
    Tribenuron 106040-48-6 NA 206 NA 205 Herbicide Sulfonylurea
    Tribenuron methyl 101200-48-0 ##### 2338 Herbicide Sulfonylurea
    Triflusulfuron-methyl 126535-15-7 ##### 3875 Herbicide Sulfonylurea
    Tritosulfuron 142469-14-5 NA 234 NA 234 Herbicide Sulfonylurea
    Butylate 2008-41-5 41405 565 Herbicide Thiocarbamate
    Calcium thylenebis 5895-18-1 14501 NA 139 Microbiocide Dithiocarbamate
    (dithiocarbamate)
    Cufraneb 11096-18-7 NA 181 NA 180 Fungicide Dithiocarbamate
    Cycloate 1134-23-2 41301 516 Herbicide Thiocarbamate
    Diammonium 607313 14502 NA 140 Microbiocide Dithiocarbamate
    ethylenebis(dithiocarbamate)
    Dimepiperate 61432-55-1 NA 186 NA 185 Herbicide Thiocarbamate
    EPTC 759-94-4 41401 264 Herbicide Thiocarbamate
    Esprocarb 85785-20-2 NA 203 NA 202 Herbicide Thiocarbamate
    Ethiolate 2941-55-1 ##### 1793 Herbicide Thiocarbamate
    Fenothiocarb 62850-32-2 NA 188 NA 187 Insecticide Thiocarbamate
    Ferbam 14484-64-1 34801 288 Fungicide Dithiocarbamate
    Ferric nitroso dimethyl 83542-83-0 ##### NA 149 Microbiocide Dithiocarbamate
    dithiocarbamate
    Furathiocarb 65907-30-4 NA 176 NA 52 Insecticide Thiocarbamate
    Isopolinate 3134-70-1 NA 232 NA 232 Herbicide Thiocarbamate
    Mancopper 53988-93-5 NA 181 NA 180 Fungicide Dithiocarbamate
    Mancozeb 2233100 14504 211 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Maneb 12427-38-2 14505 369 Fungicide Dithiocarbamate
    Maneb and nickel sulfate 8005-46-7 ##### NA 158 Fungicide Dithiocarbamate,
    hexahydrate (014505 + 050505) Inorganic-Nickel
    Manganous 15339-36-3 34802 NA 304 Fungicide Dithiocarbamate
    dimethyldithiocarbamate
    Mercuric dimethyl 15415-64-2 34808 709 Microbiocide Inorganic-Mercury,
    dithiocarbamate Heavy metal,
    Dithiocarbamate
    Metam sodium, dihydrate 137-42-8 39003 NA 163 Fumigant, Dithiocarbamate
    Fungicide,
    Microbiocide,
    Algaecide,
    Nematicide
    Metam-sodium 6734-80-1 39003 616 Fumigant, Dithiocarbamate
    Herbicide,
    Fungicide,
    Microbiocide,
    Algaecide,
    Nematicide
    Methasulfocarb 66952-49-6 NA 202 NA 201 Fungicide, Thiocarbamate
    Plant Growth
    Regulator
    Methiobencarb 18357-78-3 NA 232 NA 232 Herbicide Thiocarbamate
    Metiram 9006-42-2 14601 493 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Molinate 2212-67-1 41402 449 Herbicide Thiocarbamate
    Molinate sulfoxide NA 1052 NA 156 4080 Breakdown Thiocarbamate
    product
    Morpholinomethyl 31848-11-0 ##### NA 158 Microbiocide Dithiocarbamate
    dimethyldithiocarbamate
    Nabam 142-59-6 14503 417 Fungicide, Dithiocarbamate
    Herbicide
    Orbencarb 34622-58-7 NA 189 NA 188 Herbicide Thiocarbamate
    Pebulate 1114-71-2 41403 590 Herbicide Thiocarbamate
    Phenylmercuric 32407-99-1 66008 NA 555 Microbiocide, Organomercury,
    dimethyldithiocarbamate Fungicide Dithiocarbamate,
    Heavy metal
    Potassium ammonium 22221-14-3 14507 NA 141 Microbiocide Dithiocarbanaate
    ethylenebis(dithiocarbamate)
    Potassium dimethyl dithiocarbamate 128-03-0 34803 1934 Microbiocide Dithiocarbamate
    Potassium N-hydroxymethyl- 51026-28-9 ##### 1824 N/A Dithiocarbamate
    N-methyldithio carbamate
    Potassium N-methyldithiocarbamate 137-41-7 39002 970 Fumigant, Dithiocarbamate
    Fungicide,
    Microbiocide,
    Algaecide,
    Nematicide
    Propineb 12071-83-9 ##### NA 155 Fungicide, Dithiocarbamate,
    Microbiocide Inorganic-Zinc
    Prosulfocarb 52888-80-9 NA 185 NA 184 Herbicide Thiocarbamate
    Prothiocarb 19622-08-3 NA 183 NA 182 Fungicide Thiocarbamate
    Prothiocarb hydrochloride 19622-19-6 NA 200 NA 199 Fungicide Thiocarbamate
    Pyributicarb 88678-67-5 NA 229 NA 229 Herbicide Thiocarbamate
    S-tert-Butyl 2212-63-7 ##### NA 128 Herbicide Thiocarbamate
    dipropylthiocarbamate
    Sodium dimethyl dithiocarbamate 128-04-1 34804 548 Fungicide Dithiocarbamate
    Sulfallate 95-06-7 39001 115 Herbicide Dithiocarbamate
    Tert-butyl dimethyl trithioperoxycarbamate 3304-97-0 34807 1383 Rodent Dithiocarbamate
    Repellent
    Tert- NA 1130 NA 166 91383 N/A Dithiocarbamate
    butyldimethyltrithioperoxycarbamate,
    other related
    Thiobencarb 28249-77-6 ##### 1933 Herbicide Thiocarbamate
    Thiobencarb sulfoxide NA 1042 NA 139 2937 Breakdown Thiocarbamate
    product
    Thiodicarb 59669-26-0 ##### 2202 Molluscicide, Thiocarbamate
    Insecticide
    Thiram 137-26-8 79801 589 Fungicide Dithiocarbamate
    Thiram and NAD and IBA and 75497-92-6 56011 NA 463 Fungicide, Dithiocarbamate
    2-methyl-1- Plant Growth
    naphthaleneacetamide and 2- Regulator
    methyl-1-naphthaleneacetic
    acid
    Tiocarbazil 36756-79-3 ##### NA 911 Herbicide Thiocarbamate
    Triallate 2303-17-5 78802 49 Herbicide Thiocarbamate
    Tricopper dichloride 7076-63-3 ##### NA 152 Microbiocide Dithiocarbamate,
    dimethyldithiocarbamate Inorganic-Copper
    Vernolate 1929-77-7 41404 1987 Herbicide Thiocarbamate
    Zineb 12122-67-7 14506 627 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Zineb-ethylene thiuram NA 1465 NA 217 NA 216 Fungicide Dithiocarbamate,
    disulfide adduct Inorganic-Zinc
    Ziram 137-30-4 34805 629 Fungicide, Dithiocarbamate,
    Microbiocide, Inorganic-Zinc
    Dog and Cat
    Repellent
    Ziram, cyclohexylamine 16509-79-8 34806 1328 Dog and Cat Dithiocarbamate,
    complex Repellent, Inorganic-Zinc
    Fungicide
    1,3,5-Triethylhexahydro-s- 7779-27-3 82901 NA 823 Fungicide Triazine
    triazine
    2-(Diethylamino)-4- 3004-70-4 80812 NA 780 N/A Triazine
    (isopropylamino)-6-methoxy-s-
    triazine
    2-chloro-4- 29450-57-5 ##### NA 135 N/A Triazine
    ((hydroxymethyl)amino)-6-
    (isopropylamino)-s-triazine
    3-(chloromethyl)-4-ketobenz- 24310-41-6 ##### NA 162 Impurity Triazine
    1,2,3-triazine (as impurity)
    3-(Hydroxymethyl)-4- 24310-40-5 ##### NA 162 Impurity Triazine
    ketobenz-1,2,3-triazine (as
    impurity)
    Aatram (propachlor with 8070-76-6 80816 NA 781 Herbicide Triazine,
    atrazine) (019101 + 080803) Chloroacetanilide
    Ametryne 834-12-8 80801 18 Herbicide Triazine
    Ametryne, other related NA 1071 NA 160 90018 Herbicide Triazine
    Anilazine 101-05-3 80811 256 Fungicide Triazine
    Atraton 1610-17-9 80802 4050 Herbicide Triazine
    Atrazine 1912-24-9 80803 45 Herbicide Triazine
    Atrazine dealkylated NA 1059 NA 157 4052 Breakdown Triazine
    product
    Atrazine, other related NA 1072 NA 160 90045 Herbicide Triazine
    Aziprotryne 4658-28-0 ##### NA 130 Herbicide Triazine
    Chlorazine 580-48-3 80806 NA 777 N/A Triazine
    Cyanatryn 21689-84-9 NA 230 NA 229 Herbicide Triazine
    Cyanazine 21725-46-2 ##### 1640 Herbicide Triazine
    Cyanazine acid NA 1328 NA 178 NA 178 Breakdown Triazine
    product
    Cyanazine amide NA 1170 NA 176 NA 164 Breakdown Triazine
    product
    Cyanazine, other related NA 1133 NA 166 91640 Herbicide Triazine
    Cyanuric acid 108-80-5 81402 2138 Microbiocide, Triazine
    Water
    Treatment
    Cyanuric acid, monosodium 2624-17-1 NA 122 1031 Microbiocide, Triazine
    salt Water
    Treatment
    Cybutryne 28159-98-0 ##### 4033 Microbiocide Triazine
    Cyprazine 22936-86-3 ##### 1701 Herbicide Triazine
    Cyromazine 66215-27-8 ##### 2286 Insecticide Triazine
    Deethyl ametryne NA 1168 NA 176 NA 164 Breakdown Triazine
    product
    Deethyl hydroxyatrazine NA 1330 NA 179 NA 178 Breakdown Triazine
    product
    Deethyl-atrazine NA 1058 NA 157 4051 Breakdown Triazine
    product
    Deethyl-simazine NA 1047 NA 154 4096 Breakdown Triazine
    product
    Deethylhydroxysimazine NA 1064 NA 159 5031 Breakdown Triazine
    product
    Deisopropyl atrazine NA 1169 NA 176 NA 164 Breakdown Triazine
    product
    Deisopropyl hydroxyatrazine NA 1331 NA 179 NA 178 Breakdown Triazine
    product
    Deisopropyl prometryn NA 1334 NA 179 NA 179 Breakdown Triazine
    product
    Desamino-metribuzin NA 1473 NA 219 NA 219 Breakdown Triazine
    product
    Desmetryne 1014-69-3 80810 NA 779 Herbicide Triazine
    Diaminochlorotriazine NA 856 NA 159 5028 Breakdown Triazine
    product
    Diaminohydroxytriazine NA 857 NA 159 5032 Breakdown Triazine
    product
    Dichloro-s-triazinetrione 2782-57-2 81401 204 Microbiocide, Triazine
    Water
    Treatment
    Dichloroisocyanuric acid, 2244-21-5 81403 2 Microbiocide, Triazine
    potassium salt Water
    Treatment
    Didealkyl atrazine NA 1329 NA 178 NA 178 Breakdown Triazine
    product
    Didealkyl hydroxyatrazine NA 1332 NA 179 NA 178 Breakdown Triazine
    product
    Diketo-desamino-metribuzin NA 1475 NA 219 NA 219 Breakdown Triazine
    product
    Diketo-metribuzin NA 1474 NA 219 NA 219 Breakdown Triazine
    product
    Dimethametryn 22936-75-0 80815 2287 Herbicide Triazine
    Dipropetryn 4147-51-7 ##### 2532 Herbicide Triazine
    Eglinazine 6616-80-4 NA 207 NA 207 Herbicide Triazine
    Eglinazine-ethyl 6616-80-4 NA 218 NA 217 Herbicide Triazine
    Ethiozin (ebuzin/tycor) 64529-56-2 ##### NA 15 N/A Triazine
    Hexahydro-1,3,5-triethyl-S- 108-74-7 NA 125 1670 Herbicide Triazine
    triazine
    Hexahydro-1,3,5-tris (2- 1028251 83301 1171 Microbiocide Triazine
    hydroxyethyl)-s-triazine
    Hexahydro-1,3,5-tris(2- 25254-50-6 ##### 1915 N/A Triazine
    hydroxypropyl)-s-triazine
    Hexahydro-1,3,5-tris(3- 751061 ##### NA 127 N/A Triazine
    methoxypropyl)-1,3,5-triazine
    Hexazinone 51235-04-2 ##### 1871 Herbicide Triazine
    Hydroxyatrazine 2163-68-0 NA 178 NA 178 Breakdown Triazine
    product
    Ipazin 1912-25-0 ##### NA 130 N/A Triazine
    Isomethiozin 57052-04-7 ##### NA 875 N/A Triazine
    Metamitron 41394-05-2 NA 135 2672 Herbicide Triazine
    Methometon 1771-07-9 ##### NA 156 N/A Triazine
    Methoprotryne 841-06-5 ##### NA 154 Herbicide Triazine
    Metribuzin 21087-64-9 ##### 1692 Herbicide Triazine
    Metribuzin-DA NA 1053 NA 156 4079 Breakdown Triazine
    product
    Mono (trichloro) tetra 30622-37-8 81406 856 Microbiocide, Triazine
    (monopotassium dichloro) Water
    penta-s-triazine Treatment
    MPMT 845-52-3 82701 2695 N/A Triazine
    Potassium 1,3-dichloro-2,4,6- NA 173 NA 346 1650 N/A Triazine
    trioxo hexahydro-s-triazine
    Prefox (cyprazine with 8071-40-7 ##### NA 886 Herbicide Triazine
    ethiolate)
    Procyanazine 32889-48-8 ##### NA 908 Herbicide Triazine
    Proglinazine 68228-20-6 NA 209 NA 209 Herbicide Triazine
    Proglinazine-ethyl 68228-18-2 NA 218 NA 218 Herbicide Triazine
    Prometon 1610-18-0 80804 499 Herbicide Triazine
    Prometryn 7287-19-6 80805 502 Herbicide Triazine
    Propazine 139-40-2 80808 504 Herbicide Triazine
    Pymetrozine 123312-89-0 ##### 5232 Insecticide Triazine
    Sebuthylazine 7286-69-3 ##### NA 127 N/A Triazine
    Secbumeton 26259-45-0 ##### 2849 Herbicide Triazine
    Simazine 122-34-9 80807 531 Herbicide Triazine
    Simetone 673-04-1 ##### 3532 Herbicide Triazine
    Simetryn 1014-70-6 ##### 4097 N/A Triazine
    Sodium dichloro-s- 2893-78-9 81404 205 Microbiocide, Triazine
    triazinetrione Water
    Treatment
    Sodium dichloro-s- 51580-86-0 81407 1818 Microbiocide, Triazine
    triazinetrione dihydrate Water
    Treatment
    Sym-triazine 108-80-5 81402 893 Microbiocide, Triazine
    Water
    Treatment
    Terbumeton 33693-04-8 NA 190 NA 189 Herbicide Triazine
    Terbuthylazine 5915-41-3 80814 3004 Algaecide, Triazine
    Herbicide,
    Microbiocide
    Terbutryn 886-50-0 80813 1691 Herbicide Triazine
    Terbutryn, other related NA 1136 NA 167 91691 Herbicide Triazine
    Triaziflam 131475-57-5 NA 234 NA 233 Herbicide Triazine
    Trichloro melamine 2107336 77101 1023 Microbiocide Triazine
    Trichloro-s-triazinetrione 87-90-1 81405 407 Microbiocide, Triazine
    Water
    Treatment
    Trietazine 1912-26-1 80809 NA 778 Herbicide Triazine
    1,3-Diphenyl urea 102-07-8 NA 186 NA 185 Plant Growth Urea
    Regulator
    3,4-Dichloromethylphenyl urea NA 1335 NA 179 NA 179 Breakdown Urea
    product
    3,4-Dichlorophenyl urea 154536 NA 179 NA 179 Breakdown Urea
    product
    3-(Trifluoromethyl)phenyl urea 13114-87-9 NA 179 NA 178 Breakdown Urea
    product
    Amidosulfuron 120923-37-7 NA 183 NA 183 Herbicide Sulfonylurea
    Anisuron 2689-43-2 ##### NA 138 Herbicide Benzoylurea
    Azimsulfuron 120162-55-2 ##### NA 112 Herbicide Sulfonylurea
    Bensulfuron 99283-01-9 NA 181 NA 180 Herbicide Sulfonylurea
    Bensulfuron methyl 83055-99-6 ##### 2263 Herbicide Sulfonylurea
    Bentaluron NA 1405 NA 197 NA 197 Fungicide Urea
    Benzthiazuron 1929-88-0 ##### NA 133 Herbicide Urea
    Buthiuron 30043-55-1 NA 230 NA 230 Herbicide Urea
    Buturon 3766-60-7 ##### NA 119 Herbicide Urea
    Chlorbromuron 13360-45-7 90701 1733 Herbicide Urea
    Chloreturon 20782-58-5 NA 231 NA 230 Herbicide Phenylurea
    Chlorimuron 99283-00-8 NA 204 NA 203 Herbicide Sulfonylurea
    Chlorimuron ethyl 90982-32-4 ##### 2458 Herbicide Sulfonylurea
    Chlorotoluron 15545-48-9 ##### NA 122 Herbicide Urea
    Chloroxuron 1982-47-4 25501 576 Herbicide Urea
    Chlorsulfuron 64902-72-3 ##### 2143 Herbicide Sulfonylurea
    Cinosulfuron 94593-91-6 NA 183 NA 183 Herbicide Sulfonylurea
    Cumyluron 99485-76-4 NA 228 NA 228 Herbicide Urea
    Cyclosulfamuron 136849-15-5 NA 204 NA 203 Herbicide Sulfonylurea
    Cycluron 2163-69-1 35504 NA 306 Herbicide Urea
    Daimuron 42609-52-9 NA 204 NA 204 Herbicide Phenylurea
    Demethylfluometuron NA 1333 NA 179 NA 178 Breakdown Urea
    product
    Dichloral urea 116-52-9 ##### NA 115 Herbicide Urea
    Difenoxuron 14214-32-5 ##### NA 156 Herbicide Urea
    Diflubenzuron 35367-38-5 ##### 1992 Insecticide Benzoylurea
    Dimefuron 34205-21-5 NA 186 NA 185 Herbicide Urea
    Diuron 330-54-1 35505 231 Herbicide Urea
    Ethametsulfuron 111353-84-5 NA 212 NA 212 Herbicide Sulfonylurea
    Ethametsulfuron-methyl 97780-06-8 ##### NA 43 Herbicide Sulfonylurea
    Ethidimuron 30043-49-3 ##### NA 994 Herbicide Urea
    Ethoxysulfuron 126801-58-9 NA 226 NA 225 Herbicide Sulfonylurea
    Fenuron 101-42-8 35507 4072 Herbicide Urea
    Fenuron trichloroacetate 4482-55-7 35508 5035 Herbicide Urea
    Flazasulfuron 104040-78-0 NA 229 NA 228 Herbicide Sulfonylurea
    Flucycloxuron 113036-88-7 ##### NA 109 Herbicide Benzoylurea
    Flucycloxuron, (E) 94050-52-9 NA 201 NA 200 Herbicide Benzoylurea
    Flufenoxuron 101463-69-8 ##### NA 901 Insecticide Benzoylurea
    Fluometuron 2164-17-2 35503 166 Herbicide Urea
    Fluothiuron 33439-45-1 NA 232 NA 232 Herbicide Phenylurea
    Flupyrsulfuron 150315-10-9 NA 205 NA 204 Herbicide Sulfonylurea
    Flupyrsulfuron-methyl NA 1460 NA 216 NA 216 Herbicide Sulfonylurea
    Flupyrsulfuron-methyl, sodium 144740-54-5 NA 218 NA 217 Herbicide Sulfonylurea
    salt
    Forchlorfenuron 68157-60-8 ##### 5557 Plant Growth Urea
    Regulator
    Halosulfuron 100784-20-1 ##### 3919 Herbicide Sulfonylurea
    Hexaflumuron 86479-06-3 ##### 3899 Insecticide Benzoylurea
    Imazosulfuron 122548-33-8 NA 229 NA 229 Herbicide Sulfonylurea
    Iodosulfuron methyl 185119-76-0 NA 212 NA 211 Herbicide Sulfonylurea
    Iodosulfuron methyl, sodium 144550-36-7 NA 212 NA 211 Herbicide Sulfonylurea
    salt
    Isononuron 28805-78-9 ##### NA 151 Herbicide Urea
    Isoproturon 34123-59-6 ##### NA 155 Herbicide Urea
    Isouron 55861-78-4 ##### NA 101 Herbicide Urea
    Linuron 330-55-2 35506 361 Herbicide Urea
    Lufenuron 103055-07-8 NA 184 NA 183 Insecticide Benzoylurea
    Mesosulfuron-methyl 208465-21-8 ##### NA 993 Herbicide Sulfonylurea
    Methabenzthiazuron 18691-97-9 ##### NA 133 Herbicide Urea
    Methiuron 21540-35-2 ##### NA 145 Herbicide Urea
    Methyldymron 42609-73-4 NA 205 NA 204 Herbicide Phenylurea
    Metobenzuron 111578-32-6 ##### NA 37 Herbicide Urea
    Metobromuron 3060-89-7 35901 NA 313 Herbicide Urea
    Metoxuron 19937-59-8 ##### NA 135 Herbicide Urea
    Metsulfuron 5585-64-8 NA 183 NA 182 Herbicide Sulfonylurea
    Metsulfuron-methyl 74223-64-6 ##### 2222 Herbicide Sulfonylurea
    Monisouron 55807-46-0 NA 233 NA 232 Herbicide Urea
    Monolinuron 1746-81-2 ##### NA 119 Herbicide Urea
    Monolinuron with paraquat 69312-67-0 ##### NA 119 Herbicide Urea, Bipyridylium
    dichloride
    Monuron 150-68-5 35501 408 Herbicide Urea
    Monuron-TCA 140-41-0 35502 409 Herbicide Urea
    Neburon 555-37-3 12001 424 Herbicide Urea
    Nicosulfuron 111991-09-4 ##### 3829 Herbicide Sulfonylurea
    Norea 18530-56-8 35801 435 Herbicide Urea
    Norea (stereochemistry 2163-79-3 NA 201 NA 200 Herbicide Urea
    unspecified)
    Norea, other related NA 1096 NA 163 90435 Herbicide Urea
    Novaluron 116714-46-6 NA 226 NA 226 Herbicide Benzoylurea
    Oxasulfuron 144651-06-9 ##### NA 991 Herbicide Sulfonylurea
    Parafluron 7159-99-1 35510 NA 307 Herbicide Urea
    Pencycuron 66063-05-6 ##### NA 103 Fungicide Urea
    Penfluron 35367-31-8 ##### NA 100 Herbicide Urea
    Phenobenzuron 449583 ##### NA 133 Herbicide Benzoylurea
    Primisulfuron-methyl 86209-51-0 ##### 5103 Herbicide Sulfonylurea
    Prosulfuron 94125-34-5 ##### 5115 Herbicide Sulfonylurea
    Pyrazosulfuron 98389-04-9 NA 205 NA 205 Herbicide Sulfonylurea
    Pyrazosulfuron-ethyl 93697-74-6 NA 218 NA 217 Herbicide Sulfonylurea
    Rimsulfuron 122931-48-0 ##### 3835 Herbicide Sulfonylurea
    Siduron 1982-49-6 35509 603 Herbicide Urea
    Sulfometuron 74223-56-6 NA 206 NA 205 Herbicide Sulfonylurea
    Sulfometuron methyl 74222-97-2 ##### 2149 Herbicide Sulfonylurea
    Sulfosulfuron 141776-32-1 85601 5136 Herbicide Sulfonylurea
    Tebuthiuron 34014-18-1 ##### 1810 Herbicide Urea
    Teflubenzuron 83121-18-0 ##### NA 33 Insecticide Benzoylurea
    Tetrafluoron 27954-37-6 ##### NA 145 Herbicide Phenylurea
    Thiazafluron 25366-23-8 NA 190 NA 189 Herbicide Urea
    Thidiazuron 51707-55-2 ##### 2162 Defoliant, Plant Urea
    Growth
    Regulator
    Thifensulfuron 79277-67-1 NA 183 NA 182 Herbicide Sulfonylurea
    Thifensulfuron-methyl 79277-27-3 ##### 2237 Herbicide Sulfonylurea
    Triasulfuron 82097-50-5 ##### 5100 Herbicide Sulfonylurea
    Tribenuron 106040-48-6 NA 206 NA 205 Herbicide Sulfonylurea
    Tribenuron methyl 101200-48-0 ##### 2338 Herbicide Sulfonylurea
    Triflumuron 64628-44-0 ##### 2961 Insecticide Benzoylurea
    Triflusulfuron-methyl 126535-15-7 ##### 3875 Herbicide Sulfonylurea
    Trimeturon 3050-27-9 ##### NA 121 Herbicide Urea
    Tritosulfuron 142469-14-5 NA 234 NA 234 Herbicide Sulfonylurea
    Bromacil 314-40-9 12301 83 Herbicide Uracil
    Bromacil, dimethylamine salt 69484-13-5 12304 840 Herbicide Uracil
    Bromacil, lithium salt 53404-19-6 12302 1573 Herbicide Uracil
    Bromacil, sodium salt 69484-12-4 12303 842 Herbicide Uracil
    Butafenacil 134605-64-4 ##### NA 992 Herbicide Uracil
    Flupropacil 120890-70-2 NA 229 NA 229 Herbicide Uracil
    Isocil 314-42-1 11801 NA 119 Herbicide Uracil
    Lenacil 95177 ##### NA 155 Herbicide Uracil
    Terbacil 5902-51-2 12701 532 Herbicide Uracil
    2-Hydroxy alachlor NA 943 NA 183 2602 Breakdown Chloroacetanilide
    product
    3,4,5-tribromo salicylanilide, NA 1122 NA 165 90833 Microbiocide Anilide
    other related
    3,5-dibromosalicylanilide 2577-72-2 77405 1256 Microbiocide Anilide
    5,4-dibromosalicylanilide NA 1024 NA 122 1071 Microbiocide Anilide
    Aatram (propachlor with 8070-76-6 80816 NA 781 Herbicide Triazine,
    atrazine) (019101 + 080803) Chloroacetanilide
    Acetochlor 34256-82-1 ##### 2349 Herbicide Chloroacetanilide
    Alachlor 15972-60-8 90501 678 Herbicide Chloroacetanilide
    Benodanil 15310-01-7 ##### NA 154 Fungicide Anilide
    Butachlor 23184-66-9 ##### 4056 Herbicide Chloroacetanilide
    Butenachlor 87310-56-3 NA 206 NA 206 Herbicide Chloroacetanilide
    Clomeprop 84496-56-0 NA 204 NA 203 Herbicide Anilide
    Cyprofuram 69581-33-5 NA 186 NA 185 Fungicide Anilide
    Cypromid 2759-71-9 26101 178 Herbicide Anilide
    Delachlor 24353-58-0 ##### NA 132 Herbicide Chloroacetanilide
    Diethatyl-ethyl 38727-55-8 ##### 1995 Herbicide Chloroacetanilide
    Diflufenican 83164-33-4 NA 184 NA 183 Herbicide Anilide
    Dimethachlor 50563-36-5 NA 184 NA 183 Herbicide Chloroacetanilide
    Etobenzanid 79540-50-4 NA 229 NA 228 Herbicide Anilide
    Fenasulam 78357-48-9 NA 231 NA 231 Herbicide Anilide
    Flufenacet 142459-58-3 ##### 5293 Herbicide Anilide
    Flufenican NA 1568 NA 234 NA 234 Herbicide Anilide
    Flutolanil 66332-96-5 ##### 2305 Fungicide Anilide
    Mefenacet 73250-68-7 NA 189 NA 188 Herbicide Anilide
    Mefluidide 53780-34-0 ##### 5082 Herbicide, Anilide
    Plant Growth
    Regulator
    Mefluidide, diethanolamine salt 53780-36-2 ##### 1955 Herbicide Anilide
    Mefluidide, potassium salt 83601-83-6 ##### 5083 Herbicide Anilide
    Mepronil 55814-41-0 NA 189 NA 188 Fungicide Anilide
    Metazachlor 67129-08-2 NA 184 NA 183 Herbicide Chloroacetanilide
    Metolachlor 51218-45-2 ##### 1996 Herbicide Chloroacetanilide
    Metolachlor, (S) 87392-12-9 ##### 5133 Herbicide Chloroacetanilide
    Monalide 7287-36-7 ##### NA 134 Herbicide Anilide
    Naproanilide 52570-16-8 NA 233 NA 232 Herbicide Anilide
    Ofurace 58810-48-3 NA 189 NA 188 Fungicide Anilide
    Oxadixyl 77732-09-3 ##### 3539 Fungicide Anilide
    Perfluidone 37924-13-3 ##### 1895 Herbicide Anilide
    Perfluidone, diethanolamine NA 991 NA 671 1896 Herbicide Anilide
    salt
    Pretilachlor 51218-49-6 NA 184 NA 184 Herbicide Chloroacetanilide
    Propachlor 1918-16-7 19101 511 Herbicide Chloroacetanilide
    Propanil 709-98-8 28201 503 Herbicide Anilide
    Propisochlor 86763-47-5 NA 233 NA 233 Herbicide Chloroacetanilide
    Prynachlor 21267-72-1 ##### NA 138 Herbicide, Chloroacetanilide
    Plant Growth
    Regulator
    Pyracarbolid 24691-76-7 NA 210 NA 209 Fungicide Anilide
    Salicylanilide 87-17-2 77407 450 Fungicide, Anilide
    Microbiocide
    Sodium salicylanilide 251930 ##### NA 145 Fungicide Anilide
    Thenylchlor 96491-05-3 NA 229 NA 229 Herbicide Chloroacetanilide
    Triclocarban 101-20-2 27901 844 N/A Anilide
    1,2,4-triazole 288-88-0 NA 968 3560 N/A Azole
    1H-benzo triazole 95-14-7 NA 493 2418 N/A Azole
    2,2′-Dithiobisbenzothiazole 120-78-5 9202 NA 109 Fungicide, Mercaptobenzothiazole
    Microbiocide,
    Insecticide
    2-(2′-hydroxy-5-methyl 2440-22-4 NA 103 2607 Fungicide Azole
    phenyl)-benzotriazole
    2-(dithiocyanomethylthio)- NA 1346 NA 192 NA 191 Fungicide Mercaptobenzothiazole
    benzothiazole
    2- 79910-32-0 ##### NA 925 Microbiocide Mercaptobenzothiazole
    (thiocyanomethylthio)benzothiazole
    with 2′-hydroxyethyl-2,3-
    dibromopropionate
    2-EEEBC 62732-91-6 ##### 1983 Fungicide Benzimidazole
    2-Mercaptobenzothiazole 149-30-4 51701 556 Fungicide, Mercaptobenzothiazole
    Microbiocide
    2-Mercaptobenzothiazole, 1- 5468-43-9 51702 NA 423 Fungicide, Mercaptobenzothiazole
    (hydroxyethyl)pyridinium salt Microbiocide
    2-Mercaptobenzothiazole, 53404-53-8 51708 NA 426 Fungicide, Mercaptobenzothiazole
    ferric salt Microbiocide
    2-Mercaptobenzothiazole, 53404-58-3 9201 NA 108 Fungicide, Mercaptobenzothiazole
    manganese salt Microbiocide,
    Insecticide
    2-Mercaptobenzothiazole, 5902-85-2 51706 NA 424 Fungicide, Mercaptobenzothiazole
    monoethanolammonium salt Microbiocide
    2-Mercaptobenzothiazole, 7778-70-3 51707 NA 425 Fungicide, Mercaptobenzothiazole
    potassium salt Microbiocide
    2-Mercaptobenzothiazole, 2492-26-4 51704 3064 Microbiocide, Mercaptobenzothiazole
    sodium salt Fungicide
    2-Mercaptobenzothiazole, 2492-26-4 51704 613 Fungicide, Mercaptobenzothiazole
    sodium salt Microbiocide
    2-Mercaptobenzothiazole, zinc 155-04-4 51705 1449 Fungicide, Mercaptobenzothiazole,
    salt Microbiocide Inorganic-Zinc
    5-Chloro-2- 5331-91-9 NA 200 NA 199 N/A Mercaptobenzothiazole
    mercaptobenzothiazole
    5-Chloro-2- 5406-97-3 51703 1238 Microbiocide Mercaptobenzothiazole
    mercaptobenzothiazole, lauryl
    pyridinium salt
    5-Chloro-2- 5406-97-3 NA 421 1597 Microbiocide, Mercaptobenzothiazole
    mercaptobenzothiazole, lauryl Fungicide
    pyridinium salt
    5-Chloro-2- 53404-93-6 51709 NA 427 Microbiocide, Mercaptobenzothiazole,
    mercaptobenzothiazole, zinc Fungicide Inorganic-Zinc
    salt
    Azaconazole 60207-31-0 ##### NA 105 Insecticide, Azole
    Fungicide
    Benomyl 17804-35-2 99101 1552 Fungicide Benzimidazole
    Bitertanol 55179-31-2 ##### NA 959 Fungicide Azole
    Bromuconazole 116255-48-2 ##### NA 8 Fungicide Azole
    Carbendazim 10605-21-7 ##### 2176 Fungicide Benzimidazole
    Carbendazim hydrochloride 37574-18-8 ##### NA 121 Fungicide Benzimidazole
    Carbendazim phosphate 52316-55-9 99102 1974 Fungicide Benzimidazole
    CGA-64251 60207-93-4 ##### 2452 Fungicide Azole
    Chlorfenapyr 122453-73-0 ##### 3938 Insecticide Pyrazole
    Chlorflurazole 3615-21-2 ##### NA 139 N/A Benzimidazole
    Cyazofamid 120116-88-3 NA 216 NA 215 Fungicide Azole
    Cypendazole 28559-00-4 ##### NA 156 N/A Benzimidazole
    Cyproconazole 94361-06-5 ##### 5105 Fungicide Azole
    Difenoconazole 119446-68-3 ##### 5024 Fungicide Azole
    Diniconazole 83657-18-5 ##### 2500 Fungicide Azole
    Diniconazole (stereochemistry 83657-24-3 NA 200 NA 200 Fungicide Azole
    unspecified)
    Fenapanil 61019-78-1 ##### 2083 Fungicide Azole
    Fenbuconazole 114369-43-6 ##### 3905 Fungicide Azole
    Fluotrimazole 31251-03-3 NA 207 NA 207 Fungicide Azole
    Fluquinconazole 136426-54-5 NA 184 NA 183 Fungicide Azole
    Flusilazole 85509-19-9 ##### 2278 Fungicide Azole
    Flutriafol 76674-21-0 ##### NA 107 Fungicide Azole
    Fuberidazole 3878-19-1 ##### NA 150 Fungicide Benzimidazole
    Furconazole 112839-33-5 NA 196 NA 196 Fungicide Azole
    Furconazole-cis 112839-32-4 NA 208 NA 207 Fungicide Azole
    Hexaconazole 79983-71-4 ##### NA 23 Fungicide Azole
    Imazalil 35554-44-0 ##### 2084 Fungicide Azole
    Imazalil sulfate 58594-72-2 ##### NA 921 Fungicide Azole
    Imibenconazole 86598-92-7 NA 205 NA 204 Fungicide Azole
    Isoxachlortole 141112-06-3 NA 232 NA 232 Herbicide Cyclopropylisoxazole
    Metconazole 125116-23-6 ##### NA 101 Fungicide Azole
    Metronidazole 443-48-1 ##### 2208 Microbiocide Azole
    Myclobutanil 88671-89-0 ##### 2245 Fungicide Azole
    Naphthyl triazole stilbene NA 742 NA 135 2698 N/A Azole
    monosulfonate
    Paclobutrazol 76738-62-0 ##### 2259 Plant Growth Azole
    Regulator
    Penconazole 66246-88-6 ##### NA 109 Fungicide Azole
    Prochloraz 67747-09-5 ##### NA 29 Fungicide Azole
    Prochloraz - manganese 75747-77-2 ##### NA 104 Fungicide Azole
    complex (4:1)
    Prochloraz zinc complex NA 1555 NA 226 NA 226 Fungicide Azole
    Propiconazole 60207-90-1 ##### 2276 Fungicide Azole
    Pyrazoxyfen 71561-11-0 NA 189 NA 189 Herbicide Pyrazole
    R 23 979 imazalil base NA 451 NA 809 2844 Fungicide Azole
    TCMTB 21564-17-0 35603 971 Microbiocide, Mercaptobenzothiazole
    Fungicide
    Tebuconazole 107534-96-3 ##### 3850 Fungicide Azole
    Tebufenpyrad 119168-77-3 90102 NA 845 Insecticide Pyrazole
    Terrazole 2593-15-9 84701 580 Fungicide Azole
    Tetraconazole 112281-77-3 ##### NA 979 Fungicide Azole
    Thiabendazole 148-79-8 60101 587 Fungicide Benzimidazole
    Thiabendazole, hypophosphite 28558-32-9 60102 1952 Fungicide Benzimidazole
    salt
    Thiophanate 23564-06-9 ##### 1684 Fungicide Benzimidazole
    Thiophanate-methyl 23564-05-8 ##### 1696 Fungicide Benzimidazole
    precursor
    Tolyl triazole 29395-43-1 NA 962 2950 N/A Azole
    Triadimefon 43121-43-3 ##### 2133 Fungicide Azole
    Triadimenol 55219-65-3 ##### 2307 Fungicide, Azole
    Breakdown
    product
    Triazbutil 16227-10-4 ##### NA 931 Fungicide Azole
    Tricyclazole 41814-78-2 ##### 5002 Fungicide Azole
    Triflumizole 68694-11-1 ##### 2260 Fungicide Azole
    Triflumizole 99387-89-0 NA 201 NA 201 Fungicide Azole
    Triticonazole 131983-72-7 ##### NA 101 Fungicide Azole
    Uniconazole 83657-22-1 ##### NA 38 Plant Growth Azole
    Regulator
    2-EEEBC 62732-91-6 ##### 1983 Fungicide Benzimidazole
    Benomyl 17804-35-2 99101 1552 Fungicide Benzimidazole
    Carbendazim 10605-21-7 ##### 2176 Fungicide Benzimidazole
    Carbendazim hydrochloride 37574-18-8 ##### NA 121 Fungicide Benzimidazole
    Carbendazim phosphate 52316-55-9 99102 1974 Fungicide Benzimidazole
    Chlorflurazole 3615-21-2 ##### NA 139 N/A Benzimidazole
    Cypendazole 28559-00-4 ##### NA 156 N/A Benzimidazole
    Fuberidazole 3878-19-1 ##### NA 150 Fungicide Benzimidazole
    Thiabendazole 148-79-8 60101 587 Fungicide Benzimidazole
    Thiabendazole, hypophosphite 28558-32-9 60102 1952 Fungicide Benzimidazole
    salt
    Thiophanate 23564-06-9 ##### 1684 Fungicide Benzimidazole
    Thiophanate-methyl 23564-05-8 ##### 1696 Fungicide Benzimidazole
    precursor
    1-(3- 51971-67-6 ##### NA 110 N/A Carboxamide
    chlorophthalimido)cyclohexane
    carboxamide
    Carboxin 5234-68-4 90201 1755 Fungicide Carboxamide
    Cisanilide 34484-77-0 ##### NA 144 Herbicide Carboxamide
    Cyclafuramide 34849-42-8 ##### NA 132 Fungicide Carboxamide
    Fenfuram 24691-80-3 NA 188 NA 187 Fungicide Carboxamide
    Furmecyclox (Xyligen B) 60568-05-0 ##### NA 18 Fungicide Carboxamide
    Methfuroxam 28730-17-8 ##### NA 949 Fungicide Carboxamide
    Metsulfovax 21452-18-6 NA 189 NA 188 Fungicide Carboxamide
    Nitrofurazone (not subject to 59-87-0 ##### NA 128 N/A Carboxamide
    FIFRA: 8709-e pm 24)
    Oxycarboxin 5259-88-1 90202 1434 Fungicide Carboxamide
    p-Benzoquinone 61566-21-0 ##### NA 133 N/A Carboxamide
    semicarbazone
    Chlozolinate 72391-46-9 NA 183 NA 182 Fungicide Dicarboximide
    Iprodione 36734-19-7 ##### 2081 Fungicide Dicarboximide
    Myclozolin 54864-61-8 NA 209 NA 208 Fungicide Dicarboximide
    N-(2-Ethylhexyl)-1-isopropyl- 13358-11-7 ##### NA 121 Synergist Dicarboximide
    4-methyl-4-cyclohexene-1,2-
    dicarboximide
    N-octyl bicycloheptene 113-48-4 57001 396 Synergist Dicarboximide
    dicarboximide
    Vinclozolin 50471-44-8 ##### 2129 Fungicide Dicarboximide
    Calcium 5895-18-1 14501 NA 139 Microbiocide Dithiocarbamate
    ethylenebis(dithiocarbamate)
    Cufraneb 11096-18-7 NA 181 NA 180 Fungicide Dithiocarbamate
    Diammonium 607313 14502 NA 140 Microbiocide Dithiocarbamate
    ethylenebis(dithiocarbamate)
    Ferbam 14484-64-1 34801 288 Fungicide Dithiocarbamate
    Ferric nitroso dimethyl 83542-83-0 ##### NA 149 Microbiocide Dithiocarbamate
    dithiocarbamate
    Mancopper 53988-93-5 NA 181 NA 180 Fungicide Dithiocarbamate
    Mancozeb 2233100 14504 211 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Maneb 12427-38-2 14505 369 Fungicide Dithiocarbamate
    Maneb and nickel sulfate 8005-46-7 ##### NA 158 Fungicide Dithiocarbamate,
    hexahydrate (014505 + 050505) Inorganic-Nickel
    Manganous 15339-36-3 34802 NA 304 Fungicide Dithiocarbamate
    dimethyldithiocarbamate
    Mercuric dimethyl 15415-64-2 34808 709 Microbiocide Inorganic-Mercury,
    dithiocarbamate Heavy metal,
    Dithiocarbamate
    Metam sodium, dihydrate 137-42-8 39003 NA 163 Fumigant, Dithiocarbamate
    Fungicide,
    Microbiocide,
    Algaecide,
    Nematicide
    Metam-sodium 6734-80-1 39003 616 Fumigant, Dithiocarbamate
    Herbicide,
    Fungicide,
    Microbiocide,
    Algaecide,
    Nematicide
    Metiram 9006-42-2 14601 493 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Morpholinomethyl 31848-11-0 ##### NA 158 Microbiocide Dithiocarbamate
    dimethyldithiocarbamate
    Nabam 142-59-6 14503 417 Fungicide, Dithiocarbamate
    Herbicide
    Phenylmercuric 32407-99-1 66008 NA 555 Microbiocide, Organomercury,
    dimethyldithiocarbamate Fungicide Dithiocarbamate,
    Heavy metal
    Potassium ammonium 22221-14-3 14507 NA 141 Microbiocide Dithiocarbamate
    ethylenebis(dithiocarbamate)
    Potassium dimethyl dithiocarbamate 128-03-0 34803 1934 Microbiocide Dithiocarbamate
    Potassium N-hydroxymethyl- 51026-28-9 ##### 1824 N/A Dithiocarbamate
    N-methyldithio carbamate
    Potassium N-methyldithio 137-41-7 39002 970 Fumigant, Dithiocarbamate
    carbamate Fungicide,
    Microbiocide,
    Algaecide,
    Nematicide
    Propineb 12071-83-9 ##### NA 155 Fungicide, Dithiocarbamate,
    Microbiocide Inorganic-Zinc
    Sodium dimethyl dithio 128-04-1 34804 548 Fungicide Dithiocarbamate
    carbamate
    Sulfallate 95-06-7 39001 115 Herbicide Dithiocarbamate
    Tert-butyl dimethyl trithio 3304-97-0 34807 1383 Rodent Dithiocarbamate
    peroxycarbamate Repellent
    Tert- NA 1130 NA 166 91383 N/A Dithiocarbamate
    butyldimethyltrithioperoxycarbamate,
    other related
    Thiram 137-26-8 79801 589 Fungicide Dithiocarbamate
    Thiram and NAD and IBA and 75497-92-6 56011 NA 463 Fungicide, Dithiocarbamate
    2-methyl-1- Plant Growth
    naphthaleneacetamide and 2- Regulator
    methyl-1-naphthaleneacetic
    acid
    Tricopper dichloride 7076-63-3 ##### NA 152 Microbiocide Dithiocarbamate,
    dimethyldithiocarbamate Inorganic-Copper
    Zineb 12122-67-7 14506 627 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Zineb-ethylene thiuram NA 1465 NA 217 NA 216 Fungicide Dithiocarbamate,
    disulfide adduct Inorganic-Zinc
    Ziram 137-30-4 34805 629 Fungicide, Dithiocarbamate,
    Microbiocide, Inorganic-Zinc
    Dog and Cat
    Repellent
    Zirm, cyclohexylamine 16509-79-8 34806 1328 Dog and Cat Dithiocarbamate,
    complex Repellent, Inorganic-Zinc
    Fungicide
    2,2′-Dithiobisbenzothiazole 120-78-5 9202 NA 109 Fungicide, Mercaptobenzothiazole
    Microbiocide,
    Insecticide
    2-(dithiocyanomethylthio)- NA 1346 NA 192 NA 191 Fungicide Mercaptobenzothiazole
    benzothiazole
    2- 79910-32-0 ##### NA 925 Microbiocide Mercaptobenzothiazole
    (thiocyanomethylthio)benzothiazole
    with 2′-hydroxyethyl-2,3-
    dibromopropionate
    2-Mercaptobenzothiazole 149-30-4 51701 556 Fungicide, Mercaptobenzothiazole
    Microbiocide
    2-Mercaptobenzothiazole, 1- 5468-43-9 51702 NA 423 Fungicide, Mercaptobenzothiazole
    (hydroxyethyl)pyridinium salt Microbiocide
    2-Mercaptobenzothiazole, 53404-53-8 51708 NA 426 Fungicide, Mercaptobenzothiazole
    ferric salt Microbiocide
    2-Mercaptobenzothiazole, 53404-58-3 9201 NA 108 Fungicide, Mercaptobenzothiazole
    manganese salt Microbiocide,
    Insecticide
    2-Mercaptobenzothiazole, 5902-85-2 51706 NA 424 Fungicide, Mercaptobenzothiazole
    monoethanolammonium salt Microbiocide
    2-Mercaptobenzothiazole, 7778-70-3 51707 NA 425 Fungicide, Mercaptobenzothiazole
    potassium salt Microbiocide
    2-Mercaptobenzothiazole, 2492-26-4 51704 3064 Microbiocide, Mercaptobenzothiazole
    sodium salt Fungicide
    2-Mercaptobenzothiazole, 2492-26-4 51704 613 Fungicide, Mercaptobenzothiazole
    sodium salt Microbiocide
    2-Mercaptobenzothiazole, zinc 155-04-4 51705 1449 Fungicide, Mercaptobenzothiazole,
    salt Microbiocide Inorganic-Zinc
    5-Chloro-2- 5331-91-9 NA 200 NA 199 N/A Mercaptobenzothiazole
    mercaptobenzothiazole
    5-Chloro-2- 5406-97-3 51703 1238 Microbiocide Mercaptobenzothiazole
    mercaptobenzothiazole, lauryl
    pyridinium salt
    5-Chloro-2- 5406-97-3 NA 421 1597 Microbiocide, Mercaptobenzothiazole
    mercaptobenzothiazole, lauryl Fungicide
    pyridinium salt
    5-Chloro-2- 53404-93-6 51709 NA 427 Microbiocide, Mercaptobenzothiazole,
    mercaptobenzothiazole, zinc Fungicide Inorganic-Zinc
    salt
    TCMTB 21564-17-0 35603 971 Microbiocide, Mercaptobenzothiazole
    Fungicide
    Ancymidol 12771-68-5 ##### 1744 Plant Growth Pyrimidine
    Regulator
    Bupirimate 41483-43-6 ##### 2430 Fungicide Pyrimidine
    Cloransulam 159518-97-5 NA 231 NA 231 Herbicide Triazolopyrimidine
    Cloransulam-methyl 147150-35-4 ##### NA 112 Herbicide Triazolopyrimidine
    Dimethirimol 5221-53-4 ##### NA 128 Fungicide Pyrimidine
    Ethirimol 23947-60-6 ##### NA 129 Fungicide Pyrimidine
    Fenarimol 60168-88-9 ##### 1980 Fungicide Pyrimidine
    Ferimzone 89269-64-7 NA 203 NA 202 Fungicide Pyrimidine
    Flurprimidol 56425-91-3 ##### 2320 Plant Growth Pyrimidine
    Regulator
    Nuarimol 63284-71-9 ##### NA 126 Fungicide Pyrimidine
    Pyrimethanil 53112-28-0 ##### NA 30 Fungicide Pyrimidine
    Azoxystrobin 131860-33-8 ##### 4037 Fungicide Strobin
    Dimoxystrobin 149961-52-4 NA 211 NA 210 Fungicide Strobin
    Kresoxim-methyl 143390-89-0 ##### 5451 Fungicide Strobin
    Metominostrobin 133408-50-1 NA 211 NA 210 Fungicide Strobin
    Picoxystrobin 117428-22-5 NA 211 NA 210 Fungicide Strobin
    Pyraclostrobin 175013-18-0 NA 211 NA 210 Fungicide Strobin
    Trifloxystrobin 141517-21-7 ##### 5321 Fungicide Strobin
    chloroneb 2675-77-6 27301 135 Fungicide Substituted Benzene
    Chlorothalonil 1897-45-6 81901 677 Fungicide Substituted Benzene
    Dichlobenil 1194-65-6 27401 112 Herbicide Substituted benzene
    Dichloran 99-30-9 31301 81 Fungicide Substituted Benzene
    PCNB 82-68-8 56502 464 Fungicide, Substituted Benzene
    Nematicide,
    Algaecide
    PCNB, other related NA 1100 NA 163 90464 Fungicide, Substituted Benzene
    Algaecide,
    Nematicide
    Captafol 190444 81702 NA 787 Fungicide Thiophthalimide
    Captafol (cis isomer) 2939-80-2 81701 292 Fungicide Thiophthalimide
    Captan 133-06-2 81301 104 Fungicide Thiophthalimide
    Captan, other related NA 1074 NA 161 90104 Fungicide Thiophthalimide
    Folpet 133-07-3 81601 294 Fungicide Thiophthalimide
    Merpafol cis isomer 190444 81701 NA 163 Fungicide Thiophthalimide
    Benalaxyl 71626-11-4 ##### NA 102 Fungicide Xylylalanine
    Furalaxyl 57646-30-7 NA 188 NA 188 Fungicide Xylylalanine
    L-Metalaxyl 69516-34-3 ##### NA 929 Fungicide Xylylalanine
    Mefenoxam 70630-17-0 ##### 4011 Fungicide Xylylalanine
    Mefenoxam, other related NA 1152 NA 168 94011 Fungicide Xylylalanine
    Metalaxyl 57837-19-1 ##### 2132 Fungicide Xylylalanine
    Metalaxyl-M 70630-17-0 NA 219 NA 218 Fungicide Xylylalanine
    1-(Alkyl* amino)-3- 61791-67-1 67311 NA 586 Microbiocide Alkyl Amino Propane
    aminopropane *(47% C12,
    18% C14, 10% C18, 9% C10,
    8% C16, 8% C8)
    1-(Alkyl* amino)-3- 61791-63-7 67301 NA 583 Microbiocide Alkyl Amino Propane
    aminopropane *(as in fatty
    acids of coconut oil)
    1-(Alkyl* amino)-3- 68911-78-4 67306 NA 585 Microbiocide Alkyl Amino Propane
    aminopropane diacetate
    *(37% C18′, 29% C16,
    23% C18, 3% C16′, 3% C14,
    1.5% C18″, 1% C14′, 1% C12,
    0.5% C15)
    1-(Alkyl* amino)-3- NA 1191 67313 NA 167 Microbiocide Alkyl Amino Propane
    aminopropane diacetate *(as in
    fatty acids of coconut oil)
    1-(Alkyl* amino)-3- NA 1192 67319 NA 167 Microbiocide, Alkyl Amino Propane
    aminopropane monoacetate Algaecide
    *(47% C12, 18% C14, 10% C18,
    9% C10, 8% C16, 8% C8)
    1-(Alkyl* amino)-3- NA 1193 67304 NA 167 Microbiocide Alkyl Amino Propane
    aminopropane propionate-
    copper acetate complex
    1-(alkyl-amino)-3- NA 1494 NA 221 NA 221 Microbiocide Alkyl Amino Propane
    aminopropane hydrochloride
    1-(alkylamino)-3- 68155-37-3 67310 1830 Microbiocide Alkyl Amino Propane
    aminopropane
    1-(alkylamino)-3- NA 1495 NA 221 NA 221 Microbiocide Alkyl Amino Propane
    carboxymethylaminopropane
    1-Alkyl (C6 to C18) amino-3- NA 994 NA 721 2365 Microbiocide Alkyl Amino Propane
    aminopropane acetate
    1-alkyl (C6-C18) amino-3- 61791-64-8 67302 1954 Microbiocide Alkyl Amino Propane
    aminopropane diacetate
    1-alkylamino-2-aminopropane 61791-64-8 67302 1335 Microbiocide Alkyl Amino Propane
    monoacetate, alkyl derived
    from coconut oil fatty acids
    1-Alkylamino-3-aminopropane 68155-43-1 67309 1972 Microbiocide, Alkyl Amino Propane
    hydroxyacetate, alkyl derived Soap/Surfactant
    from coconut oil fatty acids
    Alkyl (53% C12, 19% C14, 61791-58-0 67305 1780 Microbiocide Alkyl Amino Propane
    8.5% C16, 7% C8, 6.5% C10,
    6% C18)-1,3-propane diamine
    Alkyl-1,3-propylene diamine 61790-63-7 NA 558 1380 Microbiocide, Alkyl Amino Propane
    acetate, alkyl derived from Soap/Surfactant
    coconut oil fatty acids
    Alkyl-1,3-propylene diamine 68155-42-0 ##### 1841 Microbiocide, Alkyl Amino Propane
    adipate, alkyl derived from Soap/Surfactant
    coconut oil fatty acids
    Alkyl-1,3-propylene diamine, NA 287 NA 559 1379 Microbiocide, Alkyl Amino Propane
    alkyl derived from coconut oil Soap/Surfactant
    fatty acids
    N-(2-cyanoethyl)-N-alkyl (C6-C18)- NA 187 67321 1957 Adjuvant Alkyl Amino Propane
    1,3-diamino propane
    N-Alkyl-1,3-propylene diamine 68188-29-4 67307 1735 Microbiocide, Alkyl Amino Propane
    monobenzoate, alkyl derived Soap/Surfactant
    from coconut oil fatty acids
    Tall oil fatty acid soap of N- 61790-55-4 NA 924 3463 Microbiocide, Alkyl Amino Propane
    alkyl (C16-C18) propyl Insecticide
    diamine
    2,2′-Methylenebis(4,6- 1940-43-8 55004 NA 455 Microbiocide Chlorinated Phenol
    dichlorophenol)
    2,2′-Thiobis(4,6- 97-18-7 64201 NA 539 N/A Chlorinated Phenol
    dichlorophenol)
    2,2,2-Trichloro-N- 3583-63-9 ##### NA 151 N/A Chlorinated Phenol
    (pentachlorophenyl)acetimidoyl
    chloride
    2,2-methylene bis(4,6- 68957-70-0 55006 1843 Microbiocide Chlorinated Phenol
    dichlorophenol), sodium salt
    2,3,4,6-tetrachlorophenol, 53535-27-6 63007 1725 Wood Chlorinated phenol
    potassium salt Preservative,
    Fungicide
    2,4,5-trichlorophenol 95-95-4 64210 1382 Microbiocide, Chlorinated phenol
    Algaecide
    2,4,5-Trichlorophenol salt of 53404-83-4 64211 NA 542 N/A Chlorinated Phenol
    2,6-
    bis((dimethylamino)methyl)cyclohexanone
    2,4,5-trichlorophenol, 35471-43-3 64204 1050 Microbiocide Chlorinated phenol
    potassium salt
    2,4,5-trichlorophenol, NA 1128 NA 166 91050 Microbiocide Chlorinated phenol
    potassium salt, other related
    2,4,5-trichlorophenol, sodium 136-32-3 64217 1656 Microbiocide Chlorinated phenol
    salt
    2,4,5-Trichlorophenol, sodium 3784-03-0 64220 NA 545 Microbiocide, Chlorinated Phenol
    salt Algaecide
    2,4,6-trichlorophenol 88-06-2 64212 640 Microbiocide Chlorinated phenol
    2,4-dichlorophenol 120-83-2 NA 105 2499 N/A Chlorinated phenol
    2-(trichlorophenoxy)ethyl 69633-04-1 ##### NA 152 Herbicide Chlorinated Phenol
    hydrogen sulfate
    2-chloro-4-phenylphenol 92-04-6 62206 846 Microbiocide Chlorinated Phenol
    2-chloro-4-phenylphenol, 18128-16-0 62207 1061 Microbiocide Chlorinated Phenol
    potassium salt
    2-chloro-4-phenylphenol, 31366-97-9 62215 1632 Microbiocide Chlorinated Phenol
    sodium salt
    2-Chlorophenol 95-57-8 62204 NA 504 Microbiocide Chlorinated Phenol
    3-chloro-2-biphenylol, sodium 10605-11-5 62213 NA 505 Microbiocide Chlorinated Phenol
    salt
    4 & 6-chloro-2-phenylphenol NA 964 NA 419 1566 Microbiocide Chlorinated Phenol
    4 & 6-chloro-2-phenylphenol, NA 965 NA 420 1604 Microbiocide Chlorinated Phenol
    potassium salts, mixed
    4 & 6-chloro-2-phenylphenol, NA 963 NA 413 1594 Microbiocide Chlorinated Phenol
    sodium salts, mixed
    4 & 6-chloro-2-phenylphenol, NA 1132 NA 166 91566 Microbiocide Chlorinated phenol
    other related
    4 or 6-chloro-2-phenylphenol 53537-62-5 62216 NA 507 Microbiocide Chlorinated Phenol
    4 or 6-chloro-2-phenylphenol, 53537-63-6 62214 NA 506 Microbiocide Chlorinated Phenol
    diethanolamine salt
    4,6-dichloro-2-phenylphenol 5335-24-0 64216 1062 Microbiocide Chlorinated phenol
    4,6-dichloro-2-phenylphenol, 53404-30-1 64215 1059 Microbiocide Chlorinated phenol
    potassium salt
    4-chloro-2-cyclopentyl phenol, 35471-38-6 64214 1237 Microbiocide, Chlorinated phenol
    potassium salt Fungicide
    4-chloro-2-cyclopentylphenol 13347-42-7 64202 836 Microbiocide, Chlorinated phenol
    Fungicide
    4-chloro-2-phenylphenol 607-12-5 62208 945 Microbiocide Chlorinated Phenol
    4-chloro-2-phenylphenol, 53404-21-0 62209 947 Microbiocide Chlorinated Phenol
    potassium salt
    4-chloro-2-phenylphenol, 10605-10-4 62212 946 Microbiocide Chlorinated Phenol
    sodium salt
    4-chloro-cyclopentylphenol, 53404-20-9 64218 1395 Microbiocide, Chlorinated phenol
    sodium salt Fungicide
    6-chloro-2-phenylphenol 85-97-2 62210 948 Microbiocide Chlorinated Phenol
    6-chloro-2-phenylphenol, 18128-17-1 62211 950 Microbiocide Chlorinated Phenol
    potassium salt
    6-chloro-2-phenylphenol, 63992-41-6 NA 414 949 N/A Chlorinated phenol
    sodium salt
    6-chlorothymol 89-68-9 80403 NA 775 N/A Chlorinated Phenol
    6-tert-Butyl-4-chloro-m-cresol 30894-16-7 ##### NA 127 Microbiocide Chlorinated Phenol
    Chlorbisan 4418-66-0 64208 127 Microbiocide Chlorinated Phenol
    Chloroxylenol 88-04-0 86801 925 Microbiocide Chlorinated phenol
    Copper pentachlorophenate 15773-35-0 63011 NA 512 Wood Chlorinated Phenol,
    Preservative, Inorganic-Copper
    Microbiocide,
    Algaecide,
    Fungicide
    Dehydroabietylamine 35109-57-0 4202 NA 72 Wood Chlorinated Phenol
    pentachlorophenate Preservative,
    Microbiocide,
    Algaecide,
    Fungicide
    Dichlorophene 97-23-4 55001 206 Herbicide, Chlorinated Phenol
    Fungicide,
    Microbiocide
    Disodium 2,2′- 3247-34-5 44903 NA 380 N/A Chlorinated Phenol
    methylenebis(3,4,6-
    trichlorophenate)
    Ethylmercury 22232-28-6 41504 NA 359 Microbiocide Organomercury,
    pentachlorophenate Chlorinated Phenol,
    Heavy metal
    Fenticlor 97-24-5 64209 NA 541 Microbiocide Chlorinated Phenol
    Hexachlorophene 70-30-4 44901 322 Microbiocide, Chlorinated Phenol
    Fungicide
    Hexachlorophene, sodium salt 5736-15-2 44902 413 Microbiocide Chlorinated Phenol
    Ortho-benzyl-para- 120-32-1 62201 522 Microbiocide, Chlorinated phenol
    chlorophenol Fungicide
    Ortho-benzyl-para- 35471-49-9 62202 936 Microbiocide Chlorinated phenol
    chlorophenol, potassium salt
    Ortho-benzyl-para- 3184-65-4 62203 937 Microbiocide, Chlorinated phenol
    chlorophenol, sodium salt Fungicide
    Para-chloro-meta-cresol 59-50-7 64206 1813 Microbiocide, Chlorinated Phenol
    Fungicide
    para-Chloro-ortho-cresol 1570-64-5 62190 NA 503 N/A Chlorinated Phenol
    Para-chlorophenol 106-48-9 NA 124 1572 N/A Chlorinated phenol
    PCP 87-86-5 63001 465 Wood Chlorinated Phenol
    Preservative,
    Microbiocide,
    Algaecide,
    Fungicide,
    Molluscicide,
    Herbicide
    PCP, other related NA 1101 NA 163 90465 Wood Chlorinated Phenol
    Preservative,
    Microbiocide,
    Algaecide,
    Fungicide,
    Molluscicide
    PCP, potassium salt 7978-73-6 63002 1049 Wood Chlorinated Phenol
    Preservative,
    Microbiocide,
    Algaecide,
    Fungicide,
    Molluscicide
    PCP, sodium salt 131-52-2 63003 540 Wood Chlorinated Phenol
    Preservative,
    Microbiocide,
    Algaecide,
    Fungicide,
    Molluscicide
    PCP, sodium salt, other related NA 1110 NA 164 90540 Wood Chlorinated Phenol
    Preservative,
    Microbiocide,
    Algaecide,
    Fungicide,
    Molluscicide
    Pentachlorophenol, zinc salt 2917-32-0 63008 NA 510 Wood Chlorinated Phenol,
    Preservative, Inorganic-Zinc
    Microbiocide,
    Algaecide,
    Fungicide
    Pentachlorophenyl laurate 3772-94-9 63010 NA 511 Wood Chlorinated Phenol
    Preservative,
    Microbiocide,
    Algaecide,
    Fungicide
    Potassium 2,2′- 67923-62-0 44904 NA 381 Microbiocide Chlorinated Phenol
    methylenebis(3,4,6-
    trichlorophenate)
    Potassium 2,4,6- 2591-21-1 64219 NA 544 Microbiocide Chlorinated Phenol
    trichlorophenate
    Potassium ortho-cyclopentyl- 35471-38-6 64214 1542 Microbiocide, Chlorinated phenol
    para-chlorophenate Fungicide
    Sodium 2,2′-methylenebis(4- 10254-48-5 55005 NA 456 Insecticide, Chlorinated Phenol
    chlorophenate) Fungicide,
    Microbiocide
    Sodium chlorophenates 35535-81-0 62205 773 N/A Chlorinated Phenol
    Sodium dichlorophenate NA 1399 NA 197 NA 196 Fungicide, Chlorinated Phenol
    Microbiocide
    Sodium p-chloro-m-cresolate 15733-22-9 64205 NA 540 Microbiocide Chlorinated Phenol
    Tetrachlorophenol 25167-83-3 63004 777 Wood Chlorinated phenol
    Preservative,
    Fungicide
    Tetrachlorophenol, alkylamine NA 1007 NA 938 1401 Wood Chlorinated phenol
    salt Preservative,
    Fungicide
    Tetrachlorophenol, coconut NA 1008 NA 939 1455 Wood Chlorinated phenol
    amine salt Preservative,
    Fungicide
    Tetrachlorophenol, other NA 1118 NA 165 90777 Wood Chlorinated phenol
    related Preservative,
    Fungicide
    Tetrachlorophenol, potassium 53535-27-6 63007 1753 Wood Chlorinated phenol
    salt Preservative,
    Fungicide
    Tetrachlorophenol, sodium salt 25567-55-9 63005 776 Wood Chlorinated phenol
    Preservative,
    Fungicide
    Tetrachlorophenol, sodium salt, NA 1117 NA 165 90776 Wood Chlorinated phenol
    other related Preservative,
    Fungicide
    Tetrachlorophenols, alkyl* 137543-70-5 63006 NA 509 Wood Chlorinated Phenol
    amine salt *(as in fatty acids of Preservative,
    coconut oil) Fungicide
    Trichlorophenol 95-95-4 64210 1189 Microbiocide, Chlorinated phenol
    Algaecide
    Trichlorophenol, sodium salt 136-32-3 64217 960 Microbiocide, Chlorinated phenol
    Algaecide
    Trichlorophenol, sodium salt, NA 1127 NA 166 90960 Microbiocide Chlorinated phenol
    other related
    Triclosan 3380-34-5 54901 1371 Microbiocide Chlorinated Phenol
    Vancide 30-R 6385-58-6 64203 612 Microbiocide Chlorinated Phenol
    Zinc 2,4,5-trichlorophenate 136-24-3 64221 NA 546 N/A Chlorinated Phenol,
    Inorganic-Zinc
    Zinc trichlorophenate 30143-22-7 64213 NA 543 Microbiocide Chlorinated Phenol,
    Inorganic-Zinc
    1,3-bis (dihydroxymethyl)-5,5- 6440-58-0 ##### 2298 Fungicide, Hydantoin
    dimethylhydantoin Herbicide,
    Microbiocide
    1,3-dibromo-5,5- 77-48-5 6317 4036 Microbiocide, Hydantoin
    dimethylhydantoin Fungicide,
    Herbicide
    1,3-dichloro-5,5- 118-52-5 28501 37 Microbiocide, Hydantoin
    dimethylhydantoin Fungicide,
    Herbicide
    1,3-Dichloro-5-ethyl-5- 89415-87-2 ##### 2264 Microbiocide, Hydantoin
    methylhydantoin Fungicide,
    Herbicide
    1-bromo-3-chloro-5,5-dimethyl 16079-88-2 6315 2080 Microbiocide, Hydantoin
    hydantoin Fungicide,
    Herbicide
    1-Hydroxymethyl-5,5-dimethyl 116-25-6 ##### 2306 Fungicide, Hydantoin
    hydantoin Herbicide,
    Microbiocide
    3-Bromo-1-chloro-5,5- 126-06-7 6322 NA 92 Microbiocide, Hydantoin
    dimethylhydantoin Fungicide,
    Herbicide
    3-Hydroxymethyl-5,5-dimethyl NA 1478 NA 220 NA 219 Fungicide Hydantoin
    hydantoin
    Dimethylol dimethyl hydantoin 6440-58-0 ##### 2524 Fungicide, Hydantoin
    Herbicide,
    Microbiocide
    Acetalized polyvinyl alcohol NA 1185 46926 NA 166 Microbiocide Iodine Compound
    complexed with iodine
    Alkyl (29% C14, 29% C13, NA 973 NA 557 2063 Microbiocide Iodine Compound
    21% C12, 21% C15)
    poly(oxypropylene) poly
    (oxyethylene)-iodine complex
    Alkyl (C12-C15)- NA 972 NA 556 1734 Microbiocide Iodine Compound
    poly(oxypropylene)
    poly(oxyethylene)-iodine
    complex
    Alkyl(C12-C15) NA 1195 46918 NA 168 Microbiocide Iodine Compound
    poly(oxypropylene)poly(oxyethylene)-
    iodine complex
    Alkyl* (ethyl cycloimidinium) NA 1211 46906 NA 169 Microbiocide Iodine Compound
    3-hydroxy-3-ethyl sodium
    alcoholate, 2-methyl sodium
    carboxylate-tridecyl
    polyoxyethylene ethanol
    Alkyl* dimethyl 3,4- NA 1198 46907 NA 168 Microbiocide, Iodine Compound,
    dichlorobenzyl ammonium Microbiocide Quaternary
    chloride Ammonium
    polyethoxypolypropoxypolyethoxyethanol- Compound
    iodine complex
    *(50% C12, 30% C14, 1
    Alkyl* NA 1214 46925 NA 170 Microbiocide Iodine Compound
    poly(oxypropylene)poly(oxyethylene)-
    iodine complex
    *(43% C10, 30% C14, 12% C12,
    10% C16, 5% C18)
    Butoxy polypropoxy 68610-00-4 46901 1633 Microbiocide Iodine Compound
    polyethoxy ethanol-iodine
    complex
    Diethanolamine myristate- 53404-40-3 46910 NA 406 Microbiocide Iodine Compound
    iodine complex
    Iodophors 39392-86-4 NA 213 NA 212 Microbiocide Iodine Compound
    Nonyl phenoxy poly NA 927 NA 39 1610 Microbiocide Iodine Compound
    (oxyethylene) amine sulfonate
    ethanol-iodine
    Nonyl phenoxy 35860-86-7 46903 870 Microbiocide Iodine Compound,
    polyoxyethylene ethanol-iodine Polyalkyloxy
    complex Compound
    Octylphenoxy polyethoxy 53404-04-9 46915 2172 Microbiocide, Iodine Compound
    ethanol-iodine complex Fungicide,
    Herbicide
    Poly oxyethylene ethanol 82010-75-1 46924 2261 Microbiocide Iodine Compound
    monoesters of 5- (and 6-)
    carboxy-4-hexyl-2-
    cyclohexene-1-octanoic acid,
    complex with iodine
    Poly propoxy poly ethoxy NA 232 NA 453 1828 Microbiocide Iodine Compound
    ethanol, I2 complex
    Polyethoxy polypropoxy 26617-87-8 46904 1585 Microbiocide Iodine Compound
    polyethoxy ethanol-iodine
    complex
    Polyethoxy polypropoxy NA 1286 46909 NA 174 Microbiocide Iodine Compound
    polyethoxy ethanol-iodine
    complex
    Polyethoxypolypropoxypolyethoxyethanol- NA 1287 46913 NA 175 Microbiocide Iodine Compound,
    n-alkyl (54% C12, Quaternary
    18% C14, 9% C16, 9% C18, Ammonium
    5% C10, 5% C8) di(beta- Compound
    hydroxyethyl) benzyl am
    Polyethylene glycol ether of 68439-47-4 46921 2121 Microbiocide Iodine Compound
    linear secondary alcohol-
    iodine complex
    Polyvinyl pyrrolidone-iodine 25655-41-8 46914 1611 Microbiocide Iodine Compound
    complex
    Sodium dodecylbenzene 53467-01-9 46920 1569 Microbiocide Iodine Compound
    sulfonate-iodine complex
    Sodium N-alkyl-N-palmitoyl NA 290 NA 562 1568 Microbiocide Iodine Compound
    taurate-iodine complex
    Sodium N-cyclohexyl-N- 53404-81-2 46919 2089 Microbiocide Iodine Compound
    palmitoyl taurate-iodine
    complex
    Tetraglycine hydroperiodide 7097-60-1 46923 1923 Microbiocide Iodine Compound
    Tridecylpoly(ethyleneoxy)ethanol- 53404-05-0 46911 NA 407 Microbiocide Iodine Compound
    iodine complex
    Triethanolamine octylsulfate- 82010-77-3 46922 NA 409 Microbiocide Iodine Compound
    iodine complex
    2-(4-chlorophenylmethyl)- 26530-09-6 ##### NA 125 Microbiocide Isothiazolone
    3(2H)-isothiazolone
    2-cyclohexyl-4,5-dichloro-4- 57063-29-3 ##### NA 166 Insecticide Isothiazolone
    isothiazolin-3-one
    2-cyclohexyl-4,5-dichloro-4- 57063-29-3 ##### NA 938 Insecticide Isothiazolone
    isothioazolin-3-one
    2-Methyl-3(2H)-isothiazolone, 57373-20-3 ##### NA 895 Microbiocide Isothiazolone
    calcium chloride complex
    2-methyl-4,5-trimethylene-4- 82633-79-2 ##### 5013 Microbiocide Isothiazolone
    isothiazolin-3-one
    2-methyl-4-isothiazolin-3-one 2682-20-4 ##### 2039 Microbiocide Isothiazolone
    3(2H)-chloro-2-methyl-3(2H)- 57373-19-0 ##### NA 894 Microbiocide Isothiazolone
    isothiazolone, calcium chloride
    complex
    4,5-dichloro-2-n-octyl-3(2H)- 64359-81-5 ##### 3982 Microbiocide, Isothiazolone
    isothiazolone Antifoulant
    4-chloro-2-n-octyl-3(2H)- 64359-80-4 ##### NA 102 Microbiocide Isothiazolone
    isothiazolone
    5-chloro-2-((4- 83542-80-7 ##### NA 125 Microbiocide Isothiazolone
    chlorophenyl)methyl)-3(2H)-
    isothiazolone, compd. With 2-
    ((4-chlorophenyl)methyl)-
    3(2h)-isothiazolone (1:1)
    5-chloro-2-(4- 66159-95-3 ##### NA 125 Microbiocide Isothiazolone
    chlorophenylmethyl)-3(2H)-
    isothiazolone
    5-chloro-2-methyl-4- 26172-55-4 ##### 2038 Microbiocide Isothiazolone
    isothiazolin-3-one
    5-chloro-2-methyl-4- 55965-87-2 ##### NA 896 Microbiocide Isothiazolone
    isothiazolin-3-one calcium
    chloride with 2-methyl-4-
    isothazolin-3-one calcium
    chloride
    Kathon 886 (kathon biocide) 55965-84-9 ##### NA 24 Microbiocide Isothiazolone
    Octhilinone 26530-20-1 99901 1881 Microbiocide, Isothiazolone
    Fungicide
    2,4,6-triisopropyl phenol 376389 NA 116 3492 N/A Phenols
    2,4-xylenol 105-67-9 86804 638 Solvent, Phenols
    Fungicide,
    Microbiocide
    2,6-bis (1-methyl heptadecyl)- 5012-62-4 NA 106 3069 Microbiocide Phenols
    p-cresol
    2-tert-Amylphenol 87-26-3 64119 NA 538 Microbiocide Phenols
    4-Hexylresorcinol 136-77-6 71403 NA 671 N/A Phenols
    4-Octylresorcinol 6565-70-4 71402 NA 670 N/A Phenols
    5-isopropyl-o-cresol 499-75-2 22104 1877 Microbiocide Phenols
    Butylated hydroxy toluene 128-37-0 22105 1309 Preservative Phenols
    Carbolic acid 108-95-2 64001 107 Microbiocide, Phenols
    Nematicide
    Coal tar phenols 1319-77-3 22101 1720 N/A Petroleum derivative,
    Phenols
    Cresol 1319-77-3 NA 219 NA 218 Insect Phenols
    Repellent,
    Microbiocide
    Diisobutyl cresoxy ethoxy 53466-87-8 69155 1643 Microbiocide Phenols
    ethyl dimethyl benzyl
    ammonium chloride-ortho-
    phenylphenol ethoxy nonyl
    phenol complex
    Diisopropyl cresol 31291-59-5 22107 NA 176 Microbiocide Phenols
    Diisopropyl phenols NA 170 NA 329 3638 N/A Phenols
    Hydroxymercury cresol 12379-66-7 46001 NA 390 Microbiocide Inorganic-Mercury,
    Heavy metal, Phenols
    Isopropyl cresol 499-75-2 22104 1161 Microbiocide Phenols
    Isopropyl phenol 25168-06-3 NA 155 3256 Microbiocide Phenols
    Meta-cresol 108-39-4 22102 378 Microbiocide Phenols
    Nonyl phenol 25154-52-3 NA 44 3304 Adjuvant Phenols
    o-cresol 95-48-7 NA 374 3113 Microbiocide Phenols
    o-Phenylphenol, alkyl* amine- 82010-74-0 64107 NA 533 Microbiocide Phenols, Inorganic-
    zinc salt of *(100% C18) Zinc
    o-Phenylphenol, 53404-71-0 64109 NA 534 Microbiocide Phenols
    tetradecylamine salt
    Octylphenol 27193-28-8 64118 NA 537 N/A Phenols
    Ortho-phenylphenol 90-43-7 64103 448 Microbiocide Phenols
    Ortho-phenylphenol, 52704-98-0 64116 890 Microbiocide Phenols
    ammonium salt
    Ortho-phenylphenol, potassium 13707-65-8 64108 935 Microbiocide Phenols
    salt
    Ortho-phenylphenol, sodium 132-27-4 64104 248 Microbiocide Phenols
    salt
    p-cresol 106-44-5 NA 375 3114 Microbiocide Phenols
    p-Cresyl acetate 140-39-6 NA 186 NA 186 Microbiocide Phenols
    Para-tert-amylphenol 80-46-6 64101 900 Microbiocide Phenols
    Para-tert-amylphenol, 53404-18-5 64111 1056 Microbiocide Phenols
    potassium salt
    Para-tert-butylphenol 98-54-4 64113 1000 Microbiocide Phenols
    Phenol, dodecyl-, mixed 27193-86-8 NA 656 3323 N/A Phenols
    isomers
    Phenol, ferrous salt NA 686 NA 126 1862 N/A Phenols
    Phenols 64743-03-9 NA 189 NA 189 Microbiocide, Phenols
    Herbicide
    Polyvinylpyrrolidone- 53403-98-8 64110 NA 535 Microbiocide Phenols
    orthophenylphenol complex
    Propoxur phenol 4812-20-8 ##### NA 118 Breakdown Phenols
    product
    Resorcinol 108-46-3 71401 3375 N/A Phenols
    Sodium cresolate 34689-46-8 ##### NA 142 Microbiocide Phenols
    Sodium para-tert-amylphenate 31366-95-7 64112 1541 Microbiocide, Phenols
    Fungicide
    Sodium para-tert-butylphenate 5787-50-8 64115 1540 Microbiocide Phenols
    Sodium phenate 139-02-6 64002 2164 Microbiocide Phenols
    Thymol 89-83-8 80402 991 Dye Phenols
    Xylenol (unspec. Or mixed 1300-71-6 86805 NA 837 N/A Phenols
    from 086804)
    2-(2-(p-(diisobutyl) phenoxy) 121-54-0 69122 66 Microbiocide Quaternary
    ethoxy) ethyl dimethyl Ammonium
    ammonium chloride Compound
    2-(2-(p-(diisobutyl) phenoxy) 121-54-0 69164 NA 166 Microbiocide Quaternary
    ethoxy) ethyl dimethyl Ammonium
    ammonium chloride Compound
    3-(trimethoxysilyl) propyl 27668-52-6 ##### 2127 Microbiocide Quaternary
    dimethyl octadecyl ammonium Ammonium
    chloride Compound
    3-alkoxy (C12-C15)-2- 68187-63-3 ##### 2020 N/A Quaternary
    hydroxypropyl trimethyl Ammonium
    ammonium chloride Compound
    Acylamido alkylbenzyl NA 993 NA 705 1442 Algaecide, Quaternary
    dimethyl ammonium chloride Microbiocide Ammonium
    Compound
    Alkenyl (90% C18, 10% C16) NA 1313 NA 123 1243 Microbiocide, Quaternary
    dimethyl ethyl ammonium Adjuvant Ammonium
    bromide Compound
    Alkenyl* dimethyl ethyl 6458-13-5 69102 NA 620 Algaecide, Quaternary
    ammonium bromide Microbiocide Ammonium
    *(90% C18′, 10% C16′) Compound
    Alkenyl* dimethyl ethyl NA 1187 69198 NA 167 Microbiocide Quaternary
    ammonium bromide Ammonium
    *(90% C18′, 10% C16′) Compound
    Alkyl (100% C14) dimethyl 139-08-2 69107 2373 Algaecide, Quaternary
    benzyl ammonium chloride Microbiocide Ammonium
    Compound
    Alkyl (47% C12, 18% C14, NA 986 69143 1970 Algaecide, Quaternary
    10% C18, 10% C16, 15% C8-C10) Microbiocide Ammonium
    dimethylbenzyl Compound
    ammonium chloride
    Alkyl (50% C12, 30% C14, 8023-53-8 69110 2027 Algaecide, Quaternary
    17% C16, 3% C18) dimethyl Microbiocide Ammonium
    dichlorobenzyl ammonium Compound
    chloride
    Alkyl (50% C12, 30% C14, NA 987 69143 1850 Algaecide, Quaternary
    17% C16, 3% C18) Microbiocide Ammonium
    dimethylbenzyl ammonium Compound
    chloride
    Alkyl (50% C12, 30% C14, 8045-21-4 69111 1849 Algaecide, Quaternary
    17% C16, 3% C18) Microbiocide Ammonium
    dimethylethylbenzyl Compound
    ammonium chloride
    Alkyl (50% C14, 40% C12, NA 988 69143 1846 Algaecide, Quaternary
    10% C16) dimethylbenzyl Microbiocide Ammonium
    ammonium chloride Compound
    Alkyl (50% C14, 40% C12, 68989-01-5 69171 324 Algaecide, Quaternary
    10% C16) dimethylbenzyl Microbiocide Ammonium
    ammonium saccharinate Compound
    Alkyl (53% C12, 19% C14, 61789-71-7 69140 3535 Algaecide, Quaternary
    8.5% C16, 7% C8, 6.5% C10, Microbiocide Ammonium
    6% C18) dimethyl Compound
    benzylammonium chloride
    Alkyl (58% C14, 28% C16, NA 989 69143 1912 Algaecide, Quaternary
    14% C12) dimethylbenzyl Microbiocide Ammonium
    ammonium chloride Compound
    Alkyl (58% C18, 40% C16, 68391-03-7 69163 2228 Microbiocide Quaternary
    1% C14, 1% C12) trimethyl Ammonium
    ammonium chloride Compound
    Alkyl (60% C14, 25% C12, 68424-85-1 69105 1956 Algaecide, Quaternary
    15% C16) dimethylbenzyl Microbiocide Ammonium
    ammonium chloride Compound
    Alkyl (60% C14, 30% C16, NA 976 69143 1847 Algaecide, Quaternary
    5% C12, 5% C18) Microbiocide Ammonium
    dimethylbenzyl ammonium Compound
    chloride
    Alkyl (61% C12, 23% C14, 68989-00-4 ##### 1960 Algaecide, Quaternary
    11% C16, 3% C10, 2% C8) Microbiocide Ammonium
    dimethylbenzyl ammonium Compound
    chloride
    Alkyl (61% C12, 23% C14, NA 977 69143 1975 Algaecide, Quaternary
    11% C16, 5% C18) dimethyl Microbiocide Ammonium
    benzyl ammonium chloride Compound
    Alkyl (61% C12, 23% C14, NA 978 69143 2060 Algaecide, Quaternary
    11% C16, 5% C8, C10, C18) Microbiocide Ammonium
    dimethylbenzyl ammonium Compound
    chloride
    Alkyl 61789-71-7 69140 2375 Algaecide, Quaternary
    (61% C12, 23% C14, 11% C16, 2.5% Microbiocide Ammonium
    C8 & C10, 2.5% C18) Compound
    dimethyl benzyl ammonium
    chloride
    Alkyl (65% C12, 25% C14, NA 979 69143 1971 Algaecide, Quaternary
    10% C16) dimethylbenzyl Microbiocide Ammonium
    ammonium chloride Compound
    Alkyl (67% C12, 25% C14, NA 980 69143 1853 Algaecide, Quaternary
    7% C16, 1% C8, C10, C18) Microbiocide Ammonium
    dimethylbenzyl ammonium Compound
    chloride
    Alkyl (68% C12, 32% C14) NA 1190 ##### NA 167 Algaecide, Quaternary
    dimethyl dimethylbenzyl Microbiocide Ammonium
    ammonium chloride Compound
    Alkyl (68% C12, 32% C14) 85409-23-0 69154 1854 Algaecide, Quaternary
    dimethylethylbenzyl Fungicide, Ammonium
    ammonium chloride Microbiocide Compound
    Alkyl (70% C18, 27% C16, 68391-03-7 69163 10 Microbiocide Quaternary
    3% C14) trimethyl ammonium Ammonium
    chloride Compound
    Alkyl (90% C14, 5% C12, 8023-53-8 69110 1909 Algaecide, Quaternary
    5% C16) dimethyl Microbiocide Ammonium
    dichlorobenzyl ammonium Compound
    chloride
    Alkyl (90% C14, 5% C12, 68527-84-4 69146 2057 Algaecide, Quaternary
    5% C16) dimethyl ethyl Microbiocide Ammonium
    ammonium bromide Compound
    Alkyl (90% C14, 5% C12, NA 981 69143 1977 Algaecide, Quaternary
    5% C16) dimethylbenzyl Microbiocide Ammonium
    ammonium chloride Compound
    Alkyl (93% C14, 4% C12, NA 1031 69143 1991 Algaecide, Quaternary
    3% C16) dimethylbenzyl Microbiocide Ammonium
    ammonium chloride Compound
    Alkyl (95% C14, 3% C12, 68424-85-1 69105 3855 Algaecide, Quaternary
    2% C16) dimethyl benzyl Microbiocide Ammonium
    ammonium chloride Compound
    Alkyl (95% C14, 3% C12, NA 982 69184 2152 Algaecide, Quaternary
    2% C16) dimethyl benzyl Microbiocide Ammonium
    ammonium chloride dihydrate Compound
    Alkyl (95% C14, 3% C12, NA 1322 NA 583 3897 Algaecide, Quaternary
    2% C16) dimethyl benzyl Microbiocide Ammonium
    ammonium chloride Compound
    monohydrate
    Alkyl (98% C12, 2% C14) 53516-75-9 69112 1839 Algaecide, Quaternary
    dimethyl 1-naphthylmethyl Microbiocide Ammonium
    ammonium chloride Compound
    Alkyl (C10-16) dimethyl amine 61788-90-7 NA 401 3896 Algaecide, Quaternary
    oxide Microbiocide Ammonium
    Compound
    Alkyl (C14, C12, C16) NA 985 NA 587 2374 Algaecide, Quaternary
    dimethyl benzyl ammonium Microbiocide Ammonium
    chloride Compound
    Alkyl (C8-C18) bis (2- 61789-68-2 ##### 2031 Microbiocide Quaternary
    hydroxyethyl) benzyl Ammonium
    ammonium chloride Compound
    Alkyl (C8-C18) bis (2- NA 1196 69148 NA 168 Algaecide, Quaternary
    hydroxyethyl) benzyl Microbiocide Ammonium
    ammonium chloride Compound
    Alkyl dimethyl cumenyl NA 983 NA 584 1919 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    Compound
    Alkyl dimethyl ethyl benzyl NA 974 NA 580 1002 Microbiocide Quaternary
    ammonium cyclohexyl Ammonium
    sulfonate Compound
    Alkyl dimethyl ethylbenzyl 71808-54-3 69135 1722 Algaecide, Quaternary
    ammonium cyclohexyl Microbiocide Ammonium
    sulfamate Compound
    Alkyl dimethyl isopropyl NA 975 69188 884 Microbiocide Quaternary
    benzyl ammonium chloride Ammonium
    Compound
    Alkyl monoethyoxyethanol, NA 305 NA 577 1045 Microbiocide Quaternary
    diethoxyethyl benzyl Ammonium
    ammonium chloride Compound
    Alkyl morpholinium NA 1523 NA 223 NA 223 Fungicide Quaternary
    ethosulphate (1% C14, 22% Ammonium
    C16, 77% C18) Compound
    Alkyl trimethyl ammonium 68424-92-0 ##### 1827 Microbiocide Quaternary
    bromides Ammonium
    Compound
    Alkyl(68% C12, NA 1068 NA 159 5126 Algaecide Quaternary
    32% C14)dimethyl Ammonium
    dimethylbenzyl ammonium Compound
    chloride
    Alkyl* bis(2- 91721-81-2 ##### NA 113 N/A Quaternary
    hydroxyethyl)benzyl Ammonium
    ammonium chloride Compound
    *(57% C10, 20% C12, 11% C14,
    9% C18, 2% C16, 1% C8)
    Alkyl* dimethyl 3,4- NA 1197 ##### NA 168 Algaecide, Quaternary
    dichlorobenzyl ammonium Microbiocide Ammonium
    chloride *(42% C12, 27% C14, Compound
    13% C16, 18% C8-C18)
    Alkyl* dimethyl 3,4- 68989-02-6 ##### NA 112 Algaecide, Quaternary
    dichlorobenzyl ammonium Microbiocide Ammonium
    chloride *(50% C14, 40% C12, Compound
    10% C16)
    Alkyl* dimethyl 3,4- 92129-28-7 69182 NA 648 Algaecide, Quaternary
    dichlorobenzyl ammonium Microbiocide Ammonium
    chloride *(55% C14, 23% C12, Compound
    20% C16, 2% C18)
    Alkyl* dimethyl 3,4- 68989-02-6 ##### NA 124 Algaecide, Quaternary
    dichlorobenzyl ammonium Microbiocide Ammonium
    chloride *(60% C14, 30% C16, Compound
    10% C12)
    Alkyl* dimethyl 3,4- 68989-02-6 69180 NA 646 Algaecide, Quaternary
    dichlorobenzyl ammonium Microbiocide Ammonium
    chloride *(60% C12, 25% C14, Compound
    15% C16)
    Alkyl* dimethyl 3,4- 68989-02-6 ##### NA 113 Algaecide, Quaternary
    dichlorobenzyl ammonium Microbiocide Ammonium
    chloride *(63% C12, 23% C14, Compound
    14% C16)
    Alkyl* dimethyl 3,4- 92129-28-7 69196 NA 653 Algaecide, Quaternary
    dichlorobenzyl ammonium Microbiocide Ammonium
    chloride *(65% C12, 22% C14, Compound
    10% C16, 3% C18)
    Alkyl* dimethyl 3,4- 68989-02-6 ##### NA 114 Algaecide, Quaternary
    dichlorobenzyl ammonium Microbiocide Ammonium
    chloride *(68% C12, 27% C14, Compound
    5% C16)
    Alkyl* dimethyl 3,4- 68568-47-8 ##### NA 124 Algaecide, Quaternary
    dichlorobenzyl ammonium Microbiocide Ammonium
    chloride *(75% C12, 25% C14) Compound
    Alkyl* dimethyl 3,4- 68989-02-6 ##### NA 124 Algaecide, Quaternary
    dichlorobenzyl ammonium Microbiocide Ammonium
    chloride *(75% C12, 25% C14) Compound
    Alkyl* dimethyl 3,4- 68989-02-6 69145 NA 635 Algaecide, Quaternary
    dichlorobenzyl ammonium Microbiocide Ammonium
    chloride *(90% C14, 5% C16, Compound
    5% C12)
    Alkyl* dimethyl 3,4- 68989-02-6 ##### NA 115 Algaecide, Quaternary
    dichlorobenzyl ammonium Microbiocide Ammonium
    chloride *(C12 65%, C14 25%, Compound
    C16 10%)
    Alkyl* dimethyl 3,4- NA 1198 46907 NA 168 Microbiocide, Iodine Compound,
    dichlorobenzyl ammonium Microbiocide Quaternary
    chloride Ammonium
    polyethoxypolypropoxypolyethoxyethanol- Compound
    iodine complex
    *(50% C12, 30% C14, 1
    Alkyl* dimethyl benzyl 71011-24-0 ##### NA 113 Algaecide, Quaternary
    ammonium bentonite *(as in Microbiocide Ammonium
    fatty acids of tallow) Compound
    Alkyl* dimethyl benzyl 122-18-9 69108 NA 623 Algaecide, Quaternary
    ammonium chloride *(100% Microbiocide Ammonium
    C16) Compound
    Alkyl* dimethyl benzyl 122-19-0 ##### NA 114 Algaecide, Quaternary
    ammonium chloride *(100% Microbiocide Ammonium
    C18) Compound
    Alkyl* dimethyl benzyl 68391-01-5 69195 NA 652 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    *(41% C14, 28% C12, 19% C18, Compound
    12% C16)
    Alkyl* dimethyl benzyl NA 1199 69168 NA 168 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    *(47% C12, 18% C14, 15%(C5-C15), Compound
    10% C18, 10% C16)
    Alkyl* dimethyl benzyl 8001-54-5 69106 NA 622 Microbiocide, Quaternary
    ammonium chloride Algaecide, Ammonium
    *(50% C12, 30% C14, 17% C16, Herbicide Compound
    3% C18)
    Alkyl* dimethyl benzyl 68391-01-5 ##### NA 113 Algaecide, Quaternary
    ammonium chloride *(55% Microbiocide Ammonium
    C16, 27% C12, 16% C14, 2% Compound
    C18)
    Alkyl* dimethyl benzyl 68391-01-5 69169 NA 641 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    *(55% C16, 20% C14, 20% C12, Compound
    5% C18)
    Alkyl* dimethyl benzyl NA 1200 69141 NA 168 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    *(58% C14, 28% C16, 14% C12) Compound
    Alkyl* dimethyl benzyl 68424-85-1 69161 NA 168 Algaecide, Quaternary
    ammonium chloride *(60% Microbiocide Ammonium
    C14, 30% C16, 10% C12) Compound
    Alkyl* dimethyl benzyl NA 1201 69137 NA 168 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    *(60% C14, 25% C12, 15% C16) Compound
    Alkyl* dimethyl benzyl 53516-76-0 69104 NA 621 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    *(60% C14, 30% C16, 5% C18, Compound
    5% C12)
    Alkyl* dimethyl benzyl 68391-01-5 69189 NA 650 Algaecide, Quaternary
    ammonium chloride *(61% Microbiocide Ammonium
    C12, 23% C14, 11% C16, 5% Compound
    C18)
    Alkyl* dimethyl benzyl NA 1202 ##### NA 168 Algaecide, Quaternary
    ammonium chloride *(61% Microbiocide Ammonium
    C12, 23% 014, 11% C16, 5% Compound
    C18)
    Alkyl* dimethyl benzyl NA 1203 69199 NA 169 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    *(65% C12, 23% C14, 12% C16) Compound
    Alkyl* dimethyl benzyl 68424-85-1 69157 NA 164 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    *(65% C12, 25% C14, 10% C16) Compound
    Alkyl* dimethyl benzyl 68391-01-5 69175 NA 644 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    *(67% C12, 25% C14, 7% C16, Compound
    1% C18)
    Alkyl* dimethyl benzyl NA 1204 ##### NA 169 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    *(67% C12, 25% C14, 7% C16, Compound
    1% C8, C10, and C18)
    Alkyl* dimethyl benzyl NA 1205 69142 NA 169 Microbiocide Quaternary
    ammonium chloride Ammonium
    *(67% C12, 27% C14, 6% C16) Compound
    Alkyl* dimethyl benzyl NA 1206 ##### NA 169 Algaecide, Quaternary
    ammonium chloride *(68% Microbiocide Ammonium
    C12, 25% C14, 7% C16) Compound
    Alkyl* dimethyl benzyl NA 1207 69194 NA 169 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    *(90% C14, 5% C12, 5% C16) Compound
    Alkyl* dimethyl benzyl 68424-85-1 69158 NA 164 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    *(93% C14, 4% C12, 3% C16) Compound
    Alkyl* dimethyl benzyl 68607-20-5 ##### NA 114 Algaecide, Quaternary
    ammonium chloride *(95% Microbiocide Ammonium
    C16, 5% C18) Compound
    Alkyl* dimethyl benzyl NA 1208 ##### NA 169 Algaecide, Quaternary
    ammonium chloride *(as in Microbiocide Ammonium
    fatty acids of coconut oil) Compound
    Alkyl* dimethyl benzyl NA 1209 ##### NA 169 Algaecide, Quaternary
    ammonium chloride *(C8-18) Microbiocide Ammonium
    Compound
    Alkyl* dimethyl benzyl 61790-41-8 ##### NA 114 Algaecide, Quaternary
    ammonium ion alkyl** amine Microbiocide Ammonium
    *(C12, C14, C16) **(C10, Compound
    C12, C14, C16)
    Alkyl* dimethyl 8045-22-5 69109 NA 624 Algaecide, Quaternary
    dimethylbenzyl ammonium Microbiocide Ammonium
    chloride *(50% C12, 30% C14, Compound
    17% C16, 3% C18)
    Alkyl* dimethyl ethyl 134595-54-3 69186 NA 649 Algaecide, Quaternary
    ammonium bromide *(85% Microbiocide Ammonium
    C16, 15% C18) Compound
    Alkyl* dimethyl ethyl 61788-99-6 ##### NA 113 Algaecide, Quaternary
    ammonium bromide *(mixed Microbiocide Ammonium
    alkyl and alkenyl groups as in Compound
    fatty acids of soybean oil)
    Alkyl* dimethyl ethylbenzyl 68956-79-6 69167 NA 640 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    *(60% C14, 30% C16, 5% C12, Compound
    5% C18)
    Alkyl* dimethyl ethylbenzyl 37335-68-5 69135 NA 633 Algaecide, Quaternary
    ammonium Microbiocide Ammonium
    cyclohexylsulfamate Compound
    *(50% C12, 30% C14, 17% C16,
    3% C18)
    Alkyl* trimethyl ammonium 1119-97-7 69153 NA 637 Microbiocide Quaternary
    bromide *(95% C14, 5% C16) Ammonium
    Compound
    Alkyl* trimethyl ammonium 112-00-5 ##### NA 113 Microbiocide Quaternary
    chloride *(70% C12, 30% C14) Ammonium
    Compound
    Alkyl* trimethyl ammonium 68002-63-1 69197 NA 654 Microbiocide Quaternary
    chloride *(70% C18, 27% C16, Ammonium
    3% C14) Compound
    Alkyl* trimethyl ammonium 68002-62-0 69151 NA 636 Microbiocide Quaternary
    chloride *(90% C18, 10% C16) Ammonium
    Compound
    Alkyl* trimethyl ammonium 61790-41-8 ##### NA 115 Microbiocide Quaternary
    chloride *(alkyl as in fatty Ammonium
    acids of soybean oil) Compound
    Alkyl* trimethyl ammonium 61789-18-2 ##### NA 109 Microbiocide Quaternary
    chloride *(as in fatty acids of Ammonium
    coconut oil) Compound
    Alkyl* trimethyl ammonium 68002-61-9 69139 NA 634 Microbiocide Quaternary
    chloride *derived from Ammonium
    cottonseed oil Compound
    Alkyl*-5-hydroxy-4-oxo- NA 1189 ##### NA 167 Microbiocide Quaternary
    2(4H)-pyranylmethyl dimethyl Ammonium
    ammonium chloride *(49% Compound
    C12, 17% C14, 17% C10, 10%
    C18, 9% C16, 8% C8)
    Alkyl*-N,N-bis(2- 70750-47-9 ##### NA 114 N/A Quaternary
    hydroxyethyl)methyl Ammonium
    ammonium chloride *(53% Compound
    C12, 19% C14, 8.5% C16,
    7.0% C8, 6.5% C10, 6.0%
    C18)
    Alkyl*-N-ethyl morpholinium NA 1213 69147 NA 170 Fungicide, Quaternary
    ethyl sulfate *(66% C18, Algaecide Ammonium
    25% C16, 8% C18′, 1% C14) Compound
    Alkyldimethylbenzyl NA 1368 NA 194 NA 193 Microbiocide, Quaternary
    ammonium chloride Herbicide Ammonium
    Compound
    Alkyldimethylethylbenzylammonium NA 1369 NA 194 NA 193 Microbiocide, Quaternary
    chloride Herbicide Ammonium
    Compound
    Alkyltrimethyl ammonium NA 1370 NA 194 NA 193 Microbiocide, Quaternary
    chloride Fungicide Ammonium
    Compound
    Alkyltrimethylbenzyl NA 1371 NA 194 NA 193 Herbicide Quaternary
    ammonium chloride Ammonium
    Compound
    Benzyl dimethyl octadecyl 122-19-0 ##### 1186 Microbiocide Quaternary
    ammonium chloride Ammonium
    Compound
    Benzyl((dodecylcarbamoyl)methyl) 100-95-8 69159 NA 638 Microbiocide Quaternary
    dimethyl ammonium Ammonium
    chloride Compound
    Benzyl-C12-14-alkyldimethyl 134058-54-1 69192 5069 Microbiocide Quaternary
    quaternary ammonium Ammonium
    compounds Compound
    Cetyl dimethyl ethyl 124-03-8 69156 122 Microbiocide Quaternary
    ammonium bromide Ammonium
    Compound
    Cetyl trimethyl ammonium 57-09-0 69117 116 Microbiocide, Quaternary
    bromide Herbicide Ammonium
    Compound
    Cetyl trimethyl ammonium 112-02-7 69133 NA 632 Microbiocide Quaternary
    chloride Ammonium
    Compound
    Cetylcide (95% C16, 3% C14, 124-03-8 69156 2061 Microbiocide Quaternary
    2% C12) Ammonium
    Compound
    Chlormequat 7003-89-6 NA 216 NA 215 Plant Growth Quaternary
    Regulator Ammonium
    Compound
    Chlormequat chloride 999-81-5 18101 1512 Plant Growth Quaternary
    Regulator Ammonium
    Compound
    Di(alkyl* oxypropyl)dimethyl NA 1261 69121 NA 173 Algaecide, Quaternary
    ammonium chloride *(60% C8, Microbiocide Ammonium
    40% C10) Compound
    Dialkyl (85% C18, 15% C16) 68514-95-4 NA 355 197 Microbiocide, Quaternary
    dimethyl ammonium chloride Adjuvant Ammonium
    Compound
    Dialkyl dimethyl ammonium NA 900 NA 172 5181 Microbiocide Quaternary
    polynaphthyl amine Ammonium
    Compound
    Dialkyl* dimethyl ammonium 73398-64-8 69136 2230 Microbiocide Quaternary
    chloride *(47% C12, 18% C14, Ammonium
    10% C18, 9% C10, 8% C16, Compound
    8% C8)
    Dialkyl* dimethyl ammonium 73398-64-8 ##### NA 114 Microbiocide Quaternary
    chloride *(48% C12, 17% C14, Ammonium
    10% C18, 9% C16, 8% C8, 7% Compound
    C10, 1% C6)
    Dialkyl* dimethyl ammonium 68153-33-3 ##### NA 113 Microbiocide Quaternary
    chloride *(50% C12, 20% C14, Ammonium
    15% C10, 10% C16, 5% C18) Compound
    Dialkyl* dimethyl ammonium 68910-56-5 69177 NA 645 Microbiocide Quaternary
    chloride *(50% C12, 30% C14, Ammonium
    20% C16) Compound
    Dialkyl* dimethyl ammonium 68002-59-5 69120 NA 626 Microbiocide Quaternary
    chloride *(70% C18, 26% C16, Ammonium
    4% C14) Compound
    Dialkyl* methyl benzyl 73049-75-9 69119 NA 625 Algaecide, Quaternary
    ammonium chloride *(60% Microbiocide Ammonium
    C14, 30% C16, 5% C18, 5% Compound
    C12)
    Diallyl dimethyl ammonium 26062-79-3 ##### 5092 Adjuvant Quaternary
    chloride polymers Ammonium
    Compound
    Dibenzyldimethylammonium NA 1440 NA 213 NA 213 Microbiocide Quaternary
    chloride Ammonium
    Compound
    Dicoco dimonium chloride 61789-77-3 69138 3140 Adjuvant Quaternary
    Ammonium
    Compound
    Didecyl dimethyl ammonium 148788-55-0 69208 NA 658 Microbiocide Quaternary
    carbonate and didecyl dimethyl Ammonium
    ammonium bicarbonate Compound
    Didecyl dimethyl ammonium 148812-65-1 69208 NA 659 Microbiocide Quaternary
    carbonate and didecyl dimethyl Ammonium
    ammonium bicarbonate Compound
    Didecyl dimethyl ammonium 7173-51-5 69149 1682 Microbiocide, Quaternary
    chloride Fungicide Ammonium
    Compound
    Didecyl methyl benzyl 32426-10-1 69170 NA 642 Microbiocide Quaternary
    ammonium chloride Ammonium
    Compound
    Dihydrogenated tallow 61789-81-9 69150 3153 Adjuvant Quaternary
    dimethyl ammonium Ammonium
    methosulfate Compound
    Dilauryl dimethyl ammonium 3282-73-3 ##### NA 112 Microbiocide Quaternary
    bromide Ammonium
    Compound
    Dimethyl dicoco ammonium NA 166 NA 317 1945 Microbiocide Quaternary
    chloride Ammonium
    Compound
    Dimethyl dioctadecyl NA 627 NA 114 3163 Adjuvant Quaternary
    ammonium bentonite Ammonium
    Compound
    Dioctyl dimethyl ammonium 5538-94-3 69166 1710 Microbiocide, Quaternary
    chloride Algaecide, Ammonium
    Fungicide Compound
    Distearyl dimonium chloride 107-64-2 ##### 3176 Adjuvant Quaternary
    Ammonium
    Compound
    Dodecyl di(2-hydroxyethyl) 19379-90-9 69181 NA 647 Microbiocide Quaternary
    benzyl ammonium chloride Ammonium
    Compound
    Dodecyl dimethyl 2,4,5- 53404-46-9 ##### NA 113 Microbiocide Quaternary
    trimethylbenzyl ammonium Ammonium
    chloride Compound
    Dodecyl dimethyl ammonium NA 157 NA 294 1008 Microbiocide Quaternary
    chloride Ammonium
    Compound
    Dodecyl dimethyl benzyl 1964001 69123 NA 627 Fungicide, Quaternary
    ammonium bromide Microbiocide Ammonium
    Compound
    Dodecyl dimethyl benzyl 139-07-1 69124 1167 Microbiocide, Quaternary
    ammonium chloride Herbicide Ammonium
    Compound
    Dodecyl dimethyl benzyl 22232-26-4 69128 NA 629 Microbiocide Quaternary
    ammonium Ammonium
    cyclopentanecarboxylate Compound
    Dodecyl dimethyl benzyl NA 1027 69127 1446 Fungicide, Quaternary
    ammonium naphthenate Insecticide, Ammonium
    Fungicide Compound
    Dodecyl dimethyl 53466-90-3 ##### NA 113 Microbiocide Quaternary
    trichlorobenzyl ammonium Ammonium
    chloride Compound
    Dodecylbenzyl alkyl (70% C12, 87175-02-8 ##### 1038 Algaecide, Quaternary
    30% C14) dimethyl ammonium Microbiocide Ammonium
    chloride Compound
    Dodecylbenzyl octadecyl 29932-85-2 ##### NA 113 Microbiocide Quaternary
    dimethyl ammonium chloride Ammonium
    Compound
    Dodecylbenzyl trimethyl 12379-51-0 69126 NA 628 N/A Quaternary
    ammonium 2-ethylhexanoate Ammonium
    Compound
    Dodecylbenzyl trimethyl 1330-85-4 69125 918 Adjuvant, Quaternary
    ammonium chloride Microbiocide Ammonium
    Compound
    Ecolyst NA 1174 69089 NA 165 Plant Growth Quaternary
    Regulator Ammonium
    Compound
    Ethyl dimethyl stearyl 111-98-8 ##### NA 115 Microbiocide Quaternary
    ammonium bromide Ammonium
    Compound
    Mepiquat 15302-91-7 NA 203 NA 202 Plant Growth Quaternary
    Regulator Ammonium
    Compound
    Mepiquat chloride 24307-26-4 ##### 2075 Plant Growth Quaternary
    Regulator Ammonium
    Compound
    Methyl dodecyl benzyl 1399-80-0 69129 895 Microbiocide Quaternary
    trimethyl ammonium chloride Ammonium
    Compound
    Methyl dodecyl benzyl NA 619 NA 112 2678 Microbiocide Quaternary
    trimethyl ammonium chloride Ammonium
    80% and methyl Compound
    Methyl dodecyl trimethyl NA 44 NA 83 2679 Microbiocide Quaternary
    ammonium chloride Ammonium
    Compound
    Methyl dodecyl xylene bis NA 45 NA 84 896 Microbiocide Quaternary
    (trimethyl ammonium chloride) Ammonium
    Compound
    Methyl trioctyl ammonium 5137-55-3 NA 72 3291 Adjuvant Quaternary
    chloride Ammonium
    Compound
    Morpholine dodecyl benzene 12068-08-5 ##### 3294 Microbiocide, Quaternary
    sulfonate Adjuvant, Ammonium
    Fungicide, Compound
    Insecticide
    N-(3,4-dichlorobenzyl)-N- 102-30-7 ##### 1129 Microbiocide Quaternary
    dodecyl-N,N-dimethyl Ammonium
    ammonium chloride Compound
    N-alkyl (92% C18, 8% C16)-N- 61791-34-2 69113 986 Fungicide, Quaternary
    ethyl morpholinium ethyl Microbiocide Ammonium
    sulfate Compound
    N-alkyl (soza)-N-methyl NA 281 NA 550 3020 Fungicide, Quaternary
    morpholinium sulfate Microbiocide Ammonium
    Compound
    N-cetyl-N-ethyl morpholinium 78-21-7 69113 1792 Fungicide, Quaternary
    ethyl sulfate Microbiocide Ammonium
    Compound
    N-Cetyl-N-ethyl morpholinium 78-21-7 ##### NA 174 Fungicide Quaternary
    ethyl sulfate Ammonium
    Compound
    N-Cetyl-N-ethylmorpholinium 78-21-7 69187 NA 172 Fungicide Quaternary
    ethyl sulfate Ammonium
    Compound
    N-Dialkyl (60% C14, 30% C16, 68424-87-3 NA 356 2070 Microbiocide Quaternary
    5% C12, 5% C18) methyl Ammonium
    benzyl ammonium chloride Compound
    N-isononyl-N,N-dimethyl 138698-36-9 69207 5070 Microbiocide Quaternary
    decanaminium chloride Ammonium
    Compound
    Octyl decyl dimethyl 32426-11-2 69165 1709 Microbiocide, Quaternary
    ammonium chloride Fungicide Ammonium
    Compound
    Octyl dodecyl dimethyl 10361-16-7 69190 1947 Microbiocide Quaternary
    ammonium chloride Ammonium
    Compound
    Oleyl dimethyl ethyl 14351-44-1 69132 NA 631 Microbiocide Quaternary
    ammonium bromide Ammonium
    Compound
    Oxydiethylene bis (alkyl 68607-28-3 69173 1362 Microbiocide Quaternary
    dimethyl ammonium chloride), Ammonium
    alkyl derived from coconut oil Compound
    fatty acids
    Polybromide form of NA 1164 8711 NA 163 Microbiocide Quaternary
    trimethylbenzyl ammonium Ammonium
    resin Compound
    Polyethoxypolypropoxypolyethoxyethanol- NA 1287 46913 NA 175 Microbiocide Iodine Compound,
    n-alkyl (54% C12, Quaternary
    18% C14, 9% C16, 9% C18, Ammonium
    5% C10, 5% C8) di(beta- Compound
    hydroxyethyl) benzyl am
    Polymeric quaternary NA 1463 NA 217 NA 216 Microbiocide, Quaternary
    ammonium chloride Adjuvant Ammonium
    Compound
    Polyquaternium-6 28301-34-0 NA 767 2818 Adjuvant Quaternary
    Ammonium
    Compound
    Polytrimethyl vinyl benzyl 9017-80-5 NA 119 3769 Adjuvant Quaternary
    ammonium chloride Ammonium
    Compound
    Quaternium-18 bentonite 68953-58-2 ##### 2996 Adjuvant Quaternary
    Ammonium
    Compound
    Soya ethyl morpholinium 61791-34-2 69113 3453 Fungicide, Quaternary
    ethosulfate Microbiocide Ammonium
    Compound
    Tetradecyl dimethyl benzyl 139-08-2 69107 1166 Algaecide, Quaternary
    ammonium chloride Microbiocide Ammonium
    Compound
    Tetraethyl ammonium 77-98-5 4215 NA 76 N/A Quaternary
    hydroxide Ammonium
    Compound
    2-Mercaptobenzothiazole, zinc 155-04-4 51705 1449 Fungicide, Mercaptobenzothiazole,
    salt Microbiocide Inorganic-Zinc
    5-Chloro-2- 53404-93-6 51709 NA 427 Microbiocide, Mercaptobenzothiazole,
    mercaptobenzothiazole, zinc Fungicide Inorganic-Zinc
    salt
    Acetic acid, copper (2+) salt 142-71-2 NA 697 3013 N/A Inorganic-Copper
    Alkyl*-1-(2-aminoethyl)-2- NA 1188 46606 NA 167 Microbiocide Inorganic-Nickel,
    imidazoline acetate-nickel Imidazoline
    sulfate complex
    Aluminum 7429-90-5 111 1042 N/A Inorganic
    Aluminum acetate NA 971 NA 548 3025 N/A Inorganic
    Aluminum bicarbonate NA 1043 NA 140 3026 N/A Inorganic
    Aluminum caprylate 6028-57-5 NA 549 3027 N/A Inorganic
    Aluminum chloride 7446-70-0 13901 3028 N/A Inorganic
    Aluminum diacetate 142-03-0 NA 113 3029 N/A Inorganic
    Aluminum hydroxide 21645-51-2 NA 129 2145 N/A Inorganic
    Aluminum magnesium silicate NA 1018 NA 107 2378 Adjuvant Inorganic
    Aluminum oxide 1344-28-1 NA 540 3030 N/A Inorganic
    Aluminum phosphide 20859-73-8 66501 484 Fumigant, Inorganic
    Fungicide,
    Fungicide
    Aluminum potassium sulfate 10043-67-1 ##### 3031 Herbicide, Inorganic
    Insecticide
    Aluminum silicate 1302-76-7 NA 131 2379 Adjuvant Inorganic
    Aluminum stearate 637-12-7 NA 541 3032 N/A Inorganic
    Aluminum sulfate 10043-01-3 13906 1415 Plant Growth Inorganic
    Regulator,
    Molluscicide
    Ammonia 7664-41-7 5302 22 Insecticide, Inorganic
    Deer Repellent,
    Fungicide
    Ammonium alum 7784-26-1 NA 533 3037 Repellent Inorganic
    Ammonium alum NA 1216 98501 NA 170 Adjuvant Inorganic
    Ammonium arsenate 7784-44-3 13601 2380 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Ammonium bicarbonate 1066-33-7 NA 534 3038 pH Adjustment Inorganic
    Ammonium bisulfate 7803-63-6 NA 141 3039 N/A Inorganic
    Ammonium bromide 12124-97-9 352 3040 N/A Inorganic
    Ammonium carbamate 1111-89-7 NA 141 3041 N/A Inorganic
    Ammonium carbonate 506-87-6 73501 3042 Fungicide, Inorganic
    Herbicide,
    Microbiocide,
    pH Adjustment
    Ammonium chloride 12125-02-9 ##### 3043 N/A Inorganic
    Ammonium dichromate 2149701 68305 NA 607 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Ammonium ferric sulfate 10138-04-2 NA 537 3047 Herbicide Inorganic
    Ammonium fluosilicate 16919-19-0 75301 695 Insecticide Inorganic
    Ammonium fluosilicate on 62449-69-8 75311 NA 694 Insecticide Inorganic
    silica gel
    Ammonium hydroxide 1336-21-6 5301 2381 Fungicide, pH Inorganic
    Adjustment,
    Herbicide,
    Microbiocide
    Ammonium nitrate 6484-52-2 76101 3052 Rodenticide, Inorganic
    Microbiocide
    Ammonium nitrite 13446-48-5 76201 NA 700 Rodenticide, Inorganic
    Microbiocide
    Ammonium oxalate 1113-38-8 9603 891 Microbiocide Inorganic
    Ammonium polysulfides 9080-17-5 76701 NA 707 Insecticide, Inorganic
    Fungicide
    Ammonium sulfate 7783-20-2 5601 1363 Herbicide, pH Inorganic
    Adjustment
    Ammonium thiocyanate 1762-95-4 68200 25 Synergist Inorganic
    Ammonium thiosulfate 7783-18-8 80103 892 Insecticide, Inorganic
    Fungicide,
    Herbicide
    Anhydrous zirconium (IV) 1314-23-4 79090 2204 N/A Inorganic
    oxide
    Anilinocadmium dilactate 19651-91-3 64601 NA 548 N/A Inorganic-Cadmium,
    Heavy metal
    Arsenic 7440-38-2 NA 121 710 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic acid 7778-39-4 6801 40 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic disulfide 56320-22-0 6901 NA 98 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic pentoxide 1303-28-2 6802 631 Fungicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide,
    Herbicide
    Arsenic sulfide 12612-21-4 6901 NA 99 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic trioxide 1327-53-3 7001 42 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic trisulfide 1303-33-9 6901 NA 97 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsonic acid, ammonium salt 58829-95-1 ##### NA 105 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Wood
    Preservative
    Asbestos 1332-21-4 99301 2398 Insecticide Inorganic
    Barium carbonate 513-77-9 7501 3060 N/A Inorganic
    Barium chloride 10361-37-2 NA 141 3061 N/A Inorganic
    Barium fluosilicate 17125-80-3 75302 NA 688 Insecticide Inorganic
    Barium metaborate 13701-59-2 11101 973 Fungicide Inorganic
    Barium nitrate 10022-31-8 NA 186 NA 185 Repellent Inorganic
    Barium polysulfide 50864-67-0 76704 NA 709 Insecticide, Inorganic
    Fungicide
    Barium sulfate 7727-43-7 7502 2411 N/A Inorganic
    Basic copper arsenate 16102-92-4 ##### NA 132 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Copper
    Basic lead silicate 53466-66-3 48003 NA 417 N/A Inorganic-Lead,
    Heavy metal
    Bentonite 1302-78-9 NA 496 1399 Adjuvant Inorganic
    Blast furnace slag NA 239 NA 477 2425 N/A Inorganic
    Borax 1303-96-4 11102 79 Insecticide, Inorganic
    Herbicide
    Bordeaux mixture NA 240 NA 478 80 Fungicide Inorganic-Copper
    Boric acid 10043-35-3 11001 769 Insecticide Inorganic
    Boric acid(H4B6O11), zinc 12447-61-9 ##### 5094 Fungicide Inorganic-Zinc
    salt(1:2)
    Boric oxide 1303-86-2 11002 2090 Insecticide Inorganic
    Boron 7440-42-8 ##### 2426 N/A Inorganic
    Boron sodium oxide 12179-04-3 11110 NA 116 Insecticide Inorganic
    (B4Na2O7), pentahydrate
    Bromine 7726-95-6 8701 2296 Microbiocide Inorganic
    Bromine chloride 13863-41-7 20504 2323 Microbiocide Inorganic
    Cadmium 7440-43-9 NA 460 2438 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium carbonate 513-78-0 12901 93 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium chloride 10108-64-2 12902 94 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium cocoate 72869-63-7 NA 459 3085 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium oxide 1306-19-0 ##### NA 130 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium perborate NA 969 NA 461 3086 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium sebacate 939499 12903 699 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium succinate 141-00-4 12904 92 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium sulfate 10124-36-4 12905 NA 123 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium yellow pigments NA 967 NA 448 2439 N/A Inorganic-Cadmium,
    Heavy metal
    Calcareous shale NA 230 NA 449 3595 N/A Inorganic
    Calcium arsenate 7778-44-1 13501 96 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide,
    Molluscicide
    Calcium arsenite 53404-59-4 13602 NA 129 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Calcium carbide 75-20-7 NA 450 1571 Repellent Inorganic
    Calcium carbonate 471-34-1 73502 1007 pH Adjustment, Inorganic
    Fungicide,
    Microbiocide,
    Herbicide
    Calcium carbonate, treated NA 968 NA 451 2440 pH Adjustment, Inorganic
    Fungicide,
    Microbiocide,
    Herbicide
    Calcium chlorate 10137-74-3 73302 NA 682 Defoliant, Inorganic
    Herbicide,
    Microbiocide
    Calcium chloride 10043-52-4 75605 920 Fungicide, Inorganic
    Herbicide,
    Insecticide,
    Microbiocide,
    Molluscicide,
    Dessicant, Plant
    Growth
    Regulator
    Calcium cyanide 592-01-8 74001 176 Rodenticide Inorganic
    Calcium hydroxide 1305-62-0 75601 99 pH Adjustment, Inorganic
    Fungicide,
    Microbiocide,
    Herbicide
    Calcium hypochlorite 7778-54-3 14701 326 Algaecide, Inorganic
    Water
    Treatment
    Calcium nitrite 13780-06-8 76202 NA 701 Rodenticide, Inorganic
    Microbiocide
    Calcium phosphate 10103-46-5 NA 195 NA 195 Rodenticide Inorganic
    Calcium phosphate, tribasic 7758-87-4 76401 1607 Rodenticide, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Calcium silicate 10101-39-0 72607 1908 Insecticide, Inorganic
    Adjuvant,
    Fungicide,
    Microbiocide
    Calcium sulfate 7778-18-9 5602 2442 Insecticide, Inorganic
    Herbicide
    Calcium sulfate dihydrate 10101-41-4 203 NA 163 Insecticide, Inorganic
    Herbicide
    Calcium thiosulfate 10124-41-1 80101 930 Insecticide, Inorganic
    Fungicide,
    Herbicide
    Calcium-zinc LN 193 NA 653 NA 120 3871 N/A Inorganic-Zinc
    (complex)
    Calomel 10112-91-1 52201 100 Fungicide Inorganic-Mercury,
    Heavy metal
    Carbon 7440-44-0 16001 712 Water Inorganic
    Treatment,
    Rodenticide
    Carbon black pigment 1333-86-4 NA 442 2445 Dye Inorganic
    Carbon dioxide 124-38-9 16601 2207 Fumigant, Inorganic
    Insecticide,
    Rodenticide
    Carbon disulfide 75-15-0 16401 108 Fumigant, Inorganic
    Solvent,
    Breakdown
    product,
    Nematicide
    Chlorinated trisodium 56802-99-4 ##### 2214 Water Inorganic
    phosphate (prior TSP & Treatment
    sodium hypochlorite)
    Chlorine 7782-50-5 20501 131 Microbiocide, Inorganic
    Water
    Treatment
    Chlorine dioxide 10049-04-4 20503 2053 Microbiocide, Inorganic
    Water
    Treatment
    Chlorophyllin 11006-34-1 NA 191 NA 190 Fungicide, Inorganic-Copper,
    Microbiocide Botanical
    Chromated zinc chloride NA 1026 87801 1187 Insecticide, Inorganic-
    Herbicide, Chromium(VI),
    Microbiocide Inorganic-Zinc,
    Heavy metal
    Chromic acetate 1066-30-4 21102 NA 172 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Chromic acid 7738-94-5 21101 1188 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Chromic oxide 1308-38-9 21103 NA 173 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Chromium dioxide 12018-01-8 NA 411 2470 N/A Inorganic
    Cobaltous sulfate 10124-43-3 NA 114 3110 N/A Inorganic
    Copper 7440-50-8 22501 714 Fungicide Inorganic-Copper
    Copper (from triethanolamine 82027-59-6 24403 NA 198 Algaecide Inorganic-Copper
    complex)
    Copper 2-ethylhexanoate 22221-10-9 41201 2235 Fungicide Inorganic-Copper
    Copper 3-phenylsalicylate 1250682 23801 NA 191 N/A Inorganic-Copper
    Copper 8-quinolinoleate 10380-28-6 24002 159 Fungicide, Inorganic-Copper
    Microbiocide
    Copper abietate 10248-55-2 23301 NA 184 Fungicide Inorganic-Copper
    Copper acetate 831632 44002 147 Fungicide Inorganic-Copper
    Copper ammonium acetate NA 1544 NA 225 NA 225 Fungicide Inorganic-Copper
    Copper ammonium carbonate 33113-08-5 22703 1762 Fungicide Inorganic-Copper
    Copper ammonium complex 16828-95-8 22702 3550 Fungicide Inorganic-Copper
    Copper arsenate 10103-61-4 22801 NA 178 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Copper
    Copper arsenite 10290-12-7 22401 NA 177 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Copper
    Copper as elemental from 50376-91-5 24404 NA 199 N/A Inorganic-Copper
    copper - etidronic acid complex
    Copper beta cyclodextrin NA 1366 NA 193 NA 193 Fungicide Inorganic-Copper
    hydroxide
    Copper bronze powder 7440-50-8 22501 1457 Antifoulant Inorganic-Copper
    Copper carbonate, basic 1184-64-1 22901 60 Fungicide, Inorganic-Copper
    Algaecide,
    Insecticide
    Copper chloride (anhydrous) 1344-67-8 23802 NA 192 N/A Inorganic-Copper
    Copper chloride (dihydrate) 10125-13-0 23701 NA 190 N/A Inorganic-Copper
    Copper citrate 10402-15-0 44005 1406 N/A Inorganic-Copper
    Copper citrate chelate NA 961 NA 387 3547 N/A Inorganic-Copper
    Copper complex with ammonia 67989-88-2 ##### NA 130 Fungicide Inorganic-Copper
    and ethylene diamine
    tetraacetate
    Copper cresylate 12379-42-9 23001 NA 181 Fungicide Inorganic-Copper
    Copper 53404-24-3 41202 NA 349 N/A Inorganic-Copper
    dehydroabietylammonium 2-
    ethylhexanoate
    Copper dihydrazinium sulfate 33271-65-7 50504 753 N/A Inorganic-Copper
    Copper ethanolamine complex 14215-52-2 24409 NA 201 Algaecide Inorganic-Copper
    Copper ethanolamine NA 1044 NA 146 3551 Algaecide Inorganic-Copper
    complexes, mixed
    Copper ethylenediamine 13426-91-0 24407 3549 Herbicide Inorganic-Copper
    complex
    Copper gluconate chelate 814-91-5 23305 3548 N/A Inorganic-Copper
    Copper hydrazinium sulfate 53433-02-6 50501 NA 418 Fungicide Inorganic-Copper
    Copper hydroxide 20427-59-2 23401 151 Fungicide, Inorganic-Copper
    Microbiocide,
    Nematicide
    Copper hydroxide - NA 1017 NA 105 1826 N/A Inorganic-Copper
    triethanolamine complex
    Copper isodecanoate 84082-88-2 41221 NA 354 N/A Inorganic-Copper
    Copper isononanoate 72915-82-3 41211 NA 352 N/A Inorganic-Copper
    Copper isooctanoate 88859-94-3 41204 NA 350 N/A Inorganic-Copper
    Copper lactate 16039-52-4 23302 NA 185 N/A Inorganic-Copper
    Copper linoleate 7721-15-5 23303 1110 N/A Inorganic-Copper
    Copper metaborate 39290-85-2 22802 NA 179 N/A Inorganic-Copper
    Copper monoethanolamine NA 960 NA 384 3552 N/A Inorganic-Copper
    complex
    Copper naphthenate 1338-02-9 23102 153 Wood Inorganic-Copper
    Preservative,
    Insecticide,
    Fungicide, Dog
    and Cat
    Repellent
    Copper naphthenate 1338-02-9 6000 NA 172 Wood Inorganic-Copper
    Preservative,
    Insecticide,
    Fungicide, Dog
    and Cat
    Repellent
    Copper naphthenate 1338-02-9 6300 NA 172 Wood Inorganic-Copper
    Preservative,
    Insecticide,
    Fungicide, Dog
    and Cat
    Repellent
    Copper nitroacetate 22221-12-1 23201 NA 183 N/A Inorganic-Copper
    Copper octanoate 20543-04-8 23306 5225 Fungicide Inorganic-Copper
    Copper oleate 10402-16-1 23304 154 Fungicide Inorganic-Copper
    Copper oxide (ic) 1317-38-0 42401 2231 Fungicide, Inorganic-Copper
    Insecticide
    Copper oxide (ous) 1317-39-1 25601 175 Fungicide, Inorganic-Copper
    Insecticide
    Copper oxychloride 1332-40-7 8001 156 Fungicide Inorganic-Copper
    Copper oxychloride 1332-65-6 23501 NA 186 Fungicide Inorganic-Copper
    (Cu2Cl(OH)3)
    Copper oxychloride sulfate 8012-69-9 23503 158 Fungicide Inorganic-Copper
    Copper oxysulfate 12158-97-3 23504 NA 188 N/A Inorganic-Copper
    Copper oxysulfate 82010-79-5 23504 NA 189 N/A Inorganic-Copper
    Copper pentachlorophenate 15773-35-0 63011 NA 512 Wood Chlorinated Phenol,
    Preservative, Inorganic-Copper
    Microbiocide,
    Algaecide,
    Fungicide
    Copper phosphate 10103-48-7 22902 NA 180 N/A Inorganic-Copper
    Copper phthalocyanine 147-14-8 NA 381 2479 Dye Inorganic-Copper
    Copper pyrophosphate 10102-90-6 69701 NA 663 N/A Inorganic-Copper
    Copper salts of fatty and rosin 9007-39-0 23104 155 Fungicide Inorganic-Copper
    acids
    Copper salts of the acids of tall 61789-22-8 23103 NA 182 N/A Inorganic-Copper
    oil
    Copper silicate 1344-72-5 24301 NA 197 N/A Inorganic-Copper
    Copper sodium sulfate- NA 1023 NA 121 755 N/A Inorganic-Copper
    phosphate complex
    Copper sulfate (anhydrous) 7758-98-7 24408 1778 Fungicide, Inorganic-Copper
    Algaecide,
    Molluscicide
    Copper sulfate (basic) 1344-73-6 8101 162 Fungicide, Inorganic-Copper
    Algaecide,
    Molluscicide
    Copper sulfate (pentahydrate) 7758-99-8 24401 161 Algaecide, Inorganic-Copper
    Fungicide,
    Insecticide,
    Water
    Treatment,
    Molluscicide,
    Nematicide
    Copper sulfate ethylene NA 1036 NA 132 2480 N/A Inorganic-Copper
    diamine
    Copper sulfate, monohydrate 10257-54-2 24402 1789 Fungicide, Inorganic-Copper
    Algaecide,
    Molluscicide
    Copper sulfate, tri-basic NA 1384 NA 195 NA 194 Herbicide, Inorganic-Copper
    Algaecide,
    Fungicide,
    Water
    Treatment
    Copper triethanolamine 68027-59-6 NA 125 1615 Algaecide Inorganic-Copper
    complex
    Copper-zinc chromate complex 1344-74-7 21003 163 Fungicide, Inorganic-
    Wood Chromium(VI),
    Preservative Inorganic-Zinc,
    Heavy metal,
    Inorganic-Copper
    Copper-zinc sulfate complex 55072-57-6 8102 164 Fungicide Inorganic-Zinc,
    Inorganic-Copper
    Copper-zinc sulfate complex, NA 959 NA 382 1751 Fungicide Inorganic-Zinc,
    monohydrate Inorganic-Copper
    Crag turf fungicide 531 12001-20-6 21006 NA 171 Fungicide Inorganic-Cadmium,
    (Cd—Cu—Ca—Zn-Chromate) Inorganic-
    Chromium(VI),
    Inorganic-Zinc,
    Heavy metal
    Cryolite 15096-52-3 75101 173 Insecticide Inorganic
    Cuprammonium NA 1382 NA 195 NA 194 Fungicide Inorganic-Copper
    Cupric acetoarsenite 12002-03-8 22601 2485 Wood Inorganic-arsenic,
    Preservative Heavy metal,
    Inorganic-Copper
    Cupric ferric subsulfate 12168-20-6 42402 NA 365 Molluscicide Inorganic-Copper
    complex
    Cupric fluosilicate 12062-24-7 75309 NA 692 Insecticide Inorganic-Copper
    Cupric gluconate 527-09-3 24405 3117 Fungicide Inorganic-Copper
    Cupric nitrate 3251-23-8 76102 3118 N/A Inorganic-Copper
    Cuprous and cupric oxide, 82010-82-0 42403 NA 366 N/A Inorganic-Copper
    mixed
    Cuprous chloride (Cu2Cl2) 7758-89-6 ##### 5597 Fungicide Inorganic-Copper
    Cuprous iodide 7681-65-4 ##### NA 902 N/A Inorganic-Copper
    Cuprous sulfide 22205-45-4 ##### NA 124 N/A Inorganic-Copper
    Cuprous thiocyanate 1111-67-7 25602 2108 Microbiocide Inorganic-Copper
    Device (swimming pool NA 1504 NA 222 NA 222 Algaecide Inorganic-Copper
    algaecide, copper generating)
    no guarantee required
    Device (swimming pool NA 1505 NA 222 NA 222 Algaecide Inorganic
    algaecide, peroxide) no
    guarantee required
    Device (swimming pool NA 1506 NA 222 NA 222 Algaecide Inorganic
    algaecide, salt in pool) no
    guarantee required
    Di-potassium salts of 13492-26-7 76416 NA 704 Fungicide, Inorganic
    phosphorous acid Microbiocide
    Diammonium phosphate 7783-28-0 NA 819 654 Insecticide, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide,
    pH Adjustment
    Diatomaceous earth 7631-86-9 72605 195 Insecticide, Inorganic
    Molluscicide
    Diatomaceous earth, other NA 1155 NA 173 90195 Insecticide, Inorganic
    related Molluscicide
    Dihydrogen 54453-03-1 24406 NA 200 N/A Inorganic-Copper
    {ethylenediaminetetraacetato(4-
    )}cuprate(2-)
    Disodium EDTA-copper 14025-15-1 NA 296 3173 N/A Inorganic-Copper
    Disodium mono ethanolamine 53404-45-8 76410 1608 pH Adjustment, Inorganic
    phosphate Fungicide,
    Herbicide,
    Microbiocide
    Disodium octaborate 12008-41-2 11107 5053 Insecticide Inorganic
    anhydrous
    Disodium octaborate 12280-03-4 11103 1800 Insecticide, Inorganic
    tetrahydrate Herbicide
    Disodium phosphate 7558-79-4 76403 2534 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    EDTA diammonium copper 7379-26-2 39117 1613 Algaecide Inorganic-Copper
    salt
    EDTA, copper complex 12276-01-6 39105 1135 Algaecide Inorganic-Copper
    EDTA, disodium zinc salt 14025-21-9 NA 274 3189 N/A Inorganic-Zinc
    Fatty acid* - silver complex 24927-67-1 72505 NA 675 Microbiocide, Inorganic-Silver,
    *(100% C8) Fungicide, Heavy metal
    Herbicide
    Feldspar 68476-25-5 NA 118 3656 N/A Inorganic
    Ferric chloride 7705-08-0 34901 3205 Herbicide Inorganic
    Ferric oxide 1332-37-2 NA 104 3206 N/A Inorganic
    Ferric sulfate (anhydrous) 10028-22-5 34902 1811 Herbicide Inorganic
    Ferrous ammonium sulfate 10045-89-3 50506 1307 Herbicide Inorganic
    Ferrous ammonium sulfate 7783-85-9 50509 NA 421 Herbicide Inorganic
    hexahydrate
    Ferrous sulfate 7720-78-7 NA 120 289 Herbicide, Inorganic
    Molluscicide
    Ferrous sulfate (monohydrate) 17375-41-6 50507 1812 Herbicide, Inorganic
    Defoliant
    Ferrous sulfate heptahydrate 7782-63-0 50502 1687 Herbicide Inorganic
    Granite NA
    105 NA 209 3663 N/A Inorganic
    Graphite 7782-42-5 NA 210 3217 N/A Inorganic
    Hydrated lime 1302-62-0 NA 194 3669 pH Adjustment, Inorganic
    Fungicide,
    Microbiocide,
    Herbicide
    Hydriodic acid 10034-85-2 46912 NA 408 N/A Inorganic
    Hydrocyanic acid 74-90-8 45801 NA 388 Fumigant Inorganic
    Hydrofluoric acid 7664-39-3 45601 NA 387 N/A Inorganic
    Hydrogen chloride 7647-01-0 45901 329 Fumigant Inorganic
    Fungicide,
    Nematicide, pH
    Adjustment,
    Herbicide
    Hydrogen peroxide 7722-84-1 595 1794 Microbiocide, Inorganic
    Fungicide,
    Herbicide,
    Rodenticide
    Hydrogen sulfide 2147416 NA 227 NA 227 Breakdown Inorganic
    product
    Hydrophosphorous acid NA 95 NA 189 2600 N/A Inorganic
    Hydroxymercury cresol 12379-66-7 46001 NA 390 Microbiocide Inorganic-Mercury,
    Heavy metal, Phenols
    Hypochlorous acid 7790-92-3 ##### NA 110 Water Inorganic
    Treatment,
    Microbiocide,
    pH Adjustment
    Hypoiodous acid 14332-21-9 ##### NA 153 N/A Inorganic
    Inorganic phosphate NA 940 NA 169 3671 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Iodic acid 7782-68-5 46902 NA 405 N/A Inorganic
    Iodine 7553-56-2 46905 718 Microbiocide, Inorganic
    Fungicide,
    Herbicide
    Iron 7439-89-6 NA 121 655 N/A Inorganic
    Iron oxide (Fe2O3) 1309-37-1 ##### NA 870 Herbicide Inorganic
    Iron oxide pigment NA 942 NA 175 2618 Dye Inorganic
    Iron phosphate 10045-86-0 34903 5014 Molluscicide Inorganic
    Kaolin 1332-58-7 ##### 2629 Insecticide, Inorganic
    Adjuvant,
    Fungicide,
    Microbiocide
    Lauric acid, barium cadmium 15337-60-7 NA 118 3676 Adjuvant Inorganic-Cadmium,
    salt Heavy metal
    Lead 7439-92-1 NA 134 2638 N/A Inorganic-Lead,
    Heavy metal
    Lead acetate 301-04-2 48001 NA 415 N/A Inorganic-Lead,
    Heavy metal
    Lead arsenate 7784-40-9 13503 353 Herbicide, Inorganic-arsenic,
    Insecticide, Inorganic-lead,
    Rodenticide Heavy metal
    Lead arsenate, basic 1327-31-7 13502 354 Herbicide, Inorganic-arsenic,
    Insecticide, Inorganic-lead,
    Rodenticide Heavy metal
    Lead metasilicate NA 938 NA 138 1106 N/A Inorganic-Lead,
    Heavy metal
    Lead monoxide 10190-55-3 NA 123 1271 N/A Inorganic-Lead,
    Heavy metal
    Lead naphthenate 61790-14-5 48004 3296 N/A Inorganic-Lead,
    Heavy metal
    Lignin sulfonic acid, copper NA 933 NA 126 1925 N/A Inorganic-Copper
    salt
    Lignin sulfonic acid, zinc salt NA 1014 NA 102 1768 N/A Inorganic-Zinc
    Lignin sulfonic acid, zinc, NA 1030 NA 126 1771 N/A Inorganic-Zinc
    manganese & iron salts
    Lime 1305-78-8 75604 977 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Lime phosphate NA 1432 NA 200 NA 199 Plant Growth Inorganic
    Regulator
    Lime-sulfur 1344-81-6 76702 358 Insecticide, Inorganic
    Fungicide
    Litharge 1317-36-8 48002 NA 416 N/A Inorganic-Lead,
    Heavy metal
    Lithium carbonate 554-13-2 NA 119 3924 pH Adjustment, Inorganic
    Fungicide,
    Microbiocide,
    Herbicide
    Lithium chloride 7447-41-8 ##### 5318 N/A Inorganic
    Lithium hydroxide 1310-65-2 NA 143 3267 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Lithium hypochlorite 13840-33-0 14702 922 Microbiocide, Inorganic
    Water
    Treatment
    Lithium perchlorate 2150251 NA 115 3268 N/A Inorganic
    Magnesium aluminum 1327-43-1 75310 NA 693 Insecticide Inorganic
    fluosilicate
    Magnesium arsenate 10103-50-1 13504 NA 126 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Magnesium carbonate 546-93-0 73503 2654 pH Adjustment, Inorganic
    Fungicide,
    Microbiocide,
    Herbicide
    Magnesium chlorate 10326-21-3 ##### NA 155 Defoliant, Inorganic
    Herbicide,
    Microbiocide
    Magnesium chloride 7786-30-3 13902 365 Molluscicide, Inorganic
    Herbicide,
    Insecticide,
    Microbiocide
    Magnesium chloride, 7791-18-6 NA 110 2655 Molluscicide, Inorganic
    hexahydrate Herbicide,
    Insecticide,
    Microbiocide
    Magnesium fluosilicate 16949-65-8 75304 NA 689 Insecticide Inorganic
    Magnesium lime NA 931 NA 111 3679 N/A Inorganic
    Magnesium nitrate 10377-60-3 NA 115 3269 Rodenticide, Inorganic
    Microbiocide
    Magnesium oxide 1309-48-4 9235 2656 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Magnesium phosphide 12057-74-8 66504 2085 Fumigant, Inorganic
    Rodenticide
    Magnesium silicate 1343-88-0 72601 NA 680 Insecticide, Inorganic
    Adjuvant,
    Fungicide,
    Microbiocide
    Magnesium silicate, hydrous 14807-96-6 NA 113 2658 Adjuvant Inorganic
    Magnesium sulfate 7487-88-9 50503 1339 Molluscicide, Inorganic
    Adjuvant
    Malachite (copper equivalent 1319-53-5 ##### NA 155 N/A Inorganic-Copper
    57%)
    Mancozeb 2233100 14504 211 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Maneb and nickel sulfate 8005-46-7 ##### NA 158 Fungicide Dithiocarbamate,
    hexahydrate (014505 + 050505) Inorganic-Nickel
    Manganese (II) oxide 1344-43-0 NA 104 3274 N/A Inorganic
    Manganese arsenate 7784-38-5 13506 NA 127 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Manganese carbamate NA 55 NA 103 3273 N/A Inorganic
    Manganese sulfate 7785-87-7 NA 105 658 N/A Inorganic
    Manganous oxide 1344-43-0 NA 143 3275 N/A Inorganic
    Mercuric acetate 1600-27-7 52104 NA 441 N/A Inorganic-Mercury,
    Heavy metal
    Mercuric chloride 7487-94-7 52001 372 Fungicide Inorganic-Mercury,
    Heavy metal
    Mercuric dimethyl 15415-64-2 34808 709 Microbiocide Inorganic-Mercury,
    dithiocarbamate Heavy metal,
    Dithiocarbamate
    Mercuric iodide 7774-29-0 52003 NA 438 N/A Inorganic-Mercury,
    Heavy metal
    Mercuric oleate 1191-80-6 52105 3276 N/A Inorganic-Mercury,
    Heavy metal
    Mercuric oxide 21908-53-2 52102 955 Fungicide Inorganic-Mercury,
    Heavy metal
    Mercury 7439-97-6 52301 NA 26 N/A Inorganic-Mercury,
    Heavy metal
    Mercury naphthenate 1336-96-5 52101 NA 439 Wood Inorganic-Mercury,
    Preservative, Heavy metal
    Insecticide,
    Fungicide
    Mercury pentanedione 14024-55-6 52103 NA 440 N/A Inorganic-Mercury,
    Heavy metal
    Mercury phenate 588-66-9 52106 NA 442 N/A Inorganic-Mercury,
    Heavy metal
    Metallic silver 7440-22-4 72501 2125 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Metiram 9006-42-2 14601 493 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Mica 12003-33-2 NA 118 3690 N/A Inorganic
    Mixed copper chelates or NA 1437 NA 213 NA 212 Fungicide Inorganic-Copper
    complex blend of copper salts
    Molybdenum 7439-98-7 NA 152 3903 N/A Inorganic
    Molybdic acid, disodium salt 7631-95-0 NA 135 2690 N/A Inorganic
    Mono-potassium salts of 13977-65-6 76416 NA 705 Fungicide, Inorganic
    phosphorous acid Microbiocide
    Monosodium phosphate 7558-80-7 76409 1772 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    N-(2-hydroxyethyl) ethylene NA 1025 NA 122 1130 N/A Inorganic-Copper
    diamine triacetic acid, copper
    salt
    Neodecanoic acid, copper salt 50315-14-5 97503 NA 854 N/A Inorganic-Copper
    Nickel 7440-02-0 NA 121 762 N/A Inorganic-Nickel
    Nickel diethyl hexyl acid NA 928 NA 53 3696 N/A Inorganic-Nickel
    phosphate complex
    Nickel sulfate (anhydrous) 7786-81-4 50508 NA 420 Fungicide Inorganic-Nickel
    Nickel sulfate hexahydrate 10101-97-0 50505 NA 419 Fungicide Inorganic-Nickel
    Nitric acid 7697-37-2 45951 NA 389 N/A Inorganic
    Nitric acid technical 7697-37-2 NA 47 2703 N/A Inorganic
    Nitrogen trichloride 10025-85-1 NA 50 2705 N/A Inorganic
    Nitrogen, liquified 7727-37-9 ##### 2267 Insecticide Inorganic
    Nitrous oxide 10024-97-2 NA 115 3302 N/A Inorganic
    Noury dry cobalt 12% NA 21 NA 33 2712 N/A Inorganic
    Nuxtra manganese 12% NA 746 NA 135 2719 N/A Inorganic
    catalyst
    o-Phenylphenol, alkyl* amine- 82010-74-0 64107 NA 533 Microbiocide Phenols, Inorganic-
    zinc salt of *(100% C18) Zinc
    Oxalic acid 144-62-7 9601 899 Microbiocide Inorganic
    Ozone 10028-15-6 NA 228 NA 228 Water Inorganic
    Treatment,
    Microbiocide
    p-tert- 53433-01-5 52002 NA 437 Microbiocide Inorganic-Mercury,
    Octylphenoxyethoxyethyl Heavy metal
    dimethyl benzyl ammonium
    mercuric chloride
    Paris green 12002-03-8 22601 460 Wood Inorganic-Arsenic,
    Preservative Inorganic-Copper,
    Heavy metal
    Penta potassium triphosphate 13845-36-8 76412 3319 N/A Inorganic
    Pentachlorophenol, zinc salt 2917-32-0 63008 NA 510 Wood Chlorinated Phenol,
    Preservative, Inorganic-Zinc
    Microbiocide,
    Algaecide,
    Fungicide
    Perboric acid, sodium salt NA 1160 NA 174 5452 Insecticide Inorganic
    Perboric acid, sodium salt, 10332-33-9 11105 5052 Insecticide Inorganic
    monohydrate
    Perchloric acid, calcium salt 13477-36-6 NA 670 3321 N/A Inorganic
    Perlite NA 756 NA 136 2767 N/A Inorganic
    Peroxyacetic acid 79-21-0 63201 2291 Microbiocide, Inorganic
    Fungicide,
    Herbicide,
    Rodenticide
    Peroxydisulfuric acid 13445-49-3 63601 NA 524 N/A Inorganic
    Phosphine 7803-51-2 66500 3541 Fumigant, Inorganic
    Insecticide
    Phosphoric acid 7664-38-2 76001 871 Fungicide, pH Inorganic
    Adjustment,
    Herbicide,
    Microbiocide
    Phosphoric acid, disodium salt, 10028-24-7 76415 NA 703 pH Adjustment, Inorganic
    dihydrate Fungicide,
    Herbicide,
    Microbiocide
    Phosphoric acid, 7778-77-0 76413 2777 pH Adjustment, Inorganic
    monopotassium salt Fungicide,
    Herbicide,
    Microbiocide
    Phosphoric acid, trisodium salt 56802-99-4 ##### 3851 Water Inorganic
    (chlorinated) Treatment
    Phosphorous acid 13598-36-2 76002 NA 699 Fungicide, Inorganic
    Microbiocide
    Phosphorus 7723-14-0 66502 513 N/A Inorganic
    Phosphorus pentasulfide 1314-56-3 NA 640 2778 N/A Inorganic
    Polyoxin D zinc salt 146659-78-1 ##### NA 129 Fungicide Inorganic-Zinc
    Potassium aluminum silicate NA 996 NA 774 3344 Adjuvant Inorganic
    Potassium aluminum sulfate 7784-24-9 NA 775 3345 Insecticide, Inorganic
    Herbicide
    Potassium arsenite 10124-50-2 13605 NA 131 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Potassium arsenite 13464-35-2 13605 NA 132 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Potassium azide 20762-60-1 ##### NA 898 N/A Inorganic
    Potassium bicarbonate 298-14-6 73508 5037 Fungicide Inorganic
    Potassium bifluoride 7789-29-9 75203 NA 687 N/A Inorganic
    Potassium bisulfate 7646-93-7 5605 1860 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Potassium bromide 2138164 13903 1090 Microbiocide Inorganic
    Potassium carbonate 584-08-7 73504 1620 pH Adjustment, Inorganic
    Fungicide,
    Microbiocide,
    Herbicide
    Potassium chlorate 696616 73303 3347 Defoliant, Inorganic
    Herbicide,
    Microbiocide
    Potassium chloride 7447-40-7 13904 NA 137 N/A Inorganic
    Potassium chromate 7789-00-6 68301 700 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Potassium cyanate 590-28-3 68002 NA 600 N/A Inorganic
    Potassium cyanide 151-50-8 ##### 497 Rodenticide Inorganic
    Potassium dichromate 7778-50-9 68302 2167 Wood Inorganic-
    Preservative Chromium(VI)
    Potassium hexafluoroarsenate 17029-22-0 ##### NA 160 N/A Inorganic-arsenic,
    Heavy metal
    Potassium hydroxide 1310-58-3 75602 1306 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Potassium hypochlorite 7778-66-7 ##### NA 110 Microbiocide Inorganic
    Potassium iodate 2138256 75703 NA 696 N/A Inorganic
    Potassium iodate (KH(IO3)2) 13455-24-8 75704 NA 697 N/A Inorganic
    Potassium iodide 7681-11-0 75701 1003 Microbiocide Inorganic
    Potassium mercuric iodide 7783-33-7 52107 NA 443 N/A Inorganic-Mercury,
    Heavy metal
    Potassium monopersulfate 10361-76-9 ##### NA 104 N/A Inorganic
    Potassium nitrate 7757-79-1 76103 726 Rodenticide, Inorganic
    Microbiocide
    Potassium nitrite 7758-09-0 76203 3356 Rodenticide, Inorganic
    Microbiocide
    Potassium permanganate 7722-64-7 68501 498 Fungicide, Inorganic
    Algaecide,
    Molluscicide,
    Microbiocide
    Potassium peroxydisulfate 7727-21-1 63602 1028 Microbiocide, Inorganic
    Fungicide,
    Herbicide,
    Rodenticide
    Potassium peroxymonosulfate 10058-23-8 63604 1859 Microbiocide, Inorganic
    Fungicide,
    Herbicide,
    Rodenticide
    Potassium peroxymonosulfate 37222-66-5 63607 NA 527 Microbiocide, Inorganic
    sulfate, Fungicide,
    (2KHSO5.KHSO4.K2SO4) Herbicide,
    Rodenticide
    Potassium peroxymonosulfate 70693-62-8 63607 NA 528 Microbiocide, Inorganic
    sulfate, Fungicide,
    (2KHSO5.KHSO4.K2SO4) Herbicide,
    Rodenticide
    Potassium phosphate 7778-53-2 76407 3358 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Potassium phosphate, dibasic 2138438 ##### 3359 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Potassium phosphite NA 1565 NA 229 5766 Fungicide Inorganic
    Potassium phosphonate NA 1563 NA 227 NA 227 Fungicide Inorganic
    (phosphorous acid equivalent)
    Potassium polysulfide 37199-66-9 76703 NA 708 Insecticide, Inorganic
    Fungicide
    Potassium pyrophosphate 7320-34-5 76408 1175 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Potassium silicate 1312-76-1 72606 2826 Insecticide, Inorganic
    Adjuvant,
    Fungicide,
    Microbiocide
    Potassium sulfate 7778-80-5 5603 3362 Insecticide, Inorganic
    Herbicide
    Potassium sulfite 10117-38-1 NA 785 3364 Fungicide Inorganic
    Potassium tetraborate 1332-77-0 NA 144 3365 Insecticide Inorganic
    Potassium tetrathionate 13932-13-3 75903 NA 698 Insecticide, Inorganic
    Herbicide
    Potassium thiocyanate 333-20-0 68201 NA 605 Insecticide Inorganic
    Potassium thiosulfate 10233-00-8 80102 NA 773 Insecticide, Inorganic
    Fungicide,
    Herbicide
    Potassium triiodide 12298-68-9 46917 5066 Microbiocide Inorganic
    Propineb 12071-83-9 ##### NA 155 Fungicide, Dithiocarbamate,
    Microbiocide Inorganic-Zinc
    Pumice 1332-09-8 NA 150 3777 N/A Inorganic
    Quartz sand NA 1363 NA 193 NA 192 Insect Inorganic
    Repellent
    Rock powder NA 1375 NA 194 NA 194 N/A Inorganic
    Selenium and compounds 7782-49-2 72001 NA 31 N/A Inorganic
    Selenium disulfide 7488-56-4 72003 NA 673 N/A Inorganic
    Shale NA 459 NA 821 3794 N/A Inorganic
    Silica aerogel 63231-67-4 72602 529 Insecticide, Inorganic
    Adjuvant,
    Fungicide,
    Microbiocide
    Silica gel 63231-67-4 72602 3557 Insecticide, Inorganic
    Adjuvant,
    Fungicide,
    Microbiocide
    Silica hydrate NA 461 NA 824 2853 N/A Inorganic
    Silica, crystalline-fused 60676-86-0 NA 823 2851 N/A Inorganic
    Silica, crystalline-quartz 14808-60-7 NA 138 2852 N/A Inorganic
    Silicic acid 1343-98-2 NA 825 3556 N/A Inorganic
    Silicon dioxide fresh water NA 1524 NA 223 NA 223 Insecticide Inorganic
    fossils
    Silver acetate 563-63-3 72507 NA 676 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver carbonate 534-16-7 72509 NA 678 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver chloride 7783-90-6 72506 2324 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver copper zeolite 130328-19-7 ##### NA 110 Microbiocide Inorganic-Silver,
    Heavy metal,
    Inorganic-Copper
    Silver fluoride 7775-41-9 72502 NA 674 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver iodide, colloidal 7783-96-2 NA 124 1556 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver nitrate 7761-88-8 72503 2856 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide,
    Plant Growth
    Regulator
    Silver orthophosphate 7784-09-0 72510 NA 679 Microbiocide, Inorganic-Silver,
    (Ag3PO4) Fungicide, Heavy metal
    Herbicide
    Silver oxide (Ag4O4) 1301-96-8 ##### NA 111 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver oxide (Ag4O4) 155645-89-9 ##### NA 111 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver sodium hydrogen NA 1166 72560 NA 164 Microbiocide Inorganic-Silver,
    zirconium phosphate Heavy metal
    (Ag0.18Na0.57H0.25Zr2(PO4)3)
    Silver thiocyanate 1701-93-5 68203 NA 606 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver thiuronium acrylate copolymer 53404-00-5 72701 NA 681 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver zeolite 130328-18-6 ##### NA 125 Microbiocide Inorganic-Silver,
    Heavy metal
    Silver zinc zeolite 130328-20-0 ##### NA 111 Microbiocide Inorganic-Silver,
    Inorganic-Zinc,
    Heavy metal
    Silver, ionic 14701-21-4 NA 169 5150 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Soapstone NA 465 NA 829 3797 N/A Inorganic
    Sodium 7440-23-5 NA 830 2858 N/A Inorganic
    Sodium acid phosphate 7558-80-7 76409 1413 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Sodium acid pyrophosphate 7758-16-9 NA 831 3381 pH Adjustment Inorganic
    Sodium aluminate 1302-42-7 NA 145 3382 N/A Inorganic
    Sodium aluminum fluosilicate 53404-77-6 75308 NA 691 Insecticide Inorganic
    Sodium aluminum phosphate 7785-88-8 NA 832 3383 N/A Inorganic
    Sodium arsenate 13464-38-5 13505 283 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Sodium arsenite 7784-46-5 13603 534 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide,
    Fungicide
    Sodium azide 26628-22-8 ##### NA 897 N/A Inorganic
    Sodium bicarbonate 144-55-8 73505 1134 Fungicide, pH Inorganic
    Adjustment
    Sodium bichromate dihydrate 7789-12-0 68306 3980 Wood Inorganic-
    Preservative Chromium(VI),
    Inorganic
    Sodium bifluoride 1333-83-1 75201 3385 N/A Inorganic
    Sodium binoxalate 1186-49-8 9602 NA 110 Microbiocide Inorganic
    Sodium bisulfate 7681-38-1 73201 905 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Sodium bisulfite 7631-90-5 78201 547 pH Adjustment, Inorganic
    Fungicide
    Sodium borohydride 16940-66-2 NA 834 3387 N/A Inorganic
    Sodium bromate 7789-38-0 13908 NA 138 N/A Inorganic
    Sodium bromide 7647-15-6 13907 1103 Molluscicide, Inorganic
    Herbicide,
    Insecticide,
    Microbiocide
    Sodium carbonate 497-19-8 73506 854 pH Adjustment, Inorganic
    Fungicide,
    Microbiocide,
    Herbicide
    Sodium chlorate 2144591 73301 536 Defoliant, Inorganic
    Herbicide,
    Microbiocide
    Sodium chloride 7647-14-5 13905 721 Molluscicide, Inorganic
    Herbicide,
    Insecticide,
    Microbiocide
    Sodium chlorite 7758-19-2 20502 2148 Microbiocide, Inorganic
    Water
    Treatment
    Sodium chromate 2144646 68303 1241 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Sodium cyanide 143-33-9 74002 688 Rodenticide Inorganic
    Sodium dichromate 10588-01-9 68304 3395 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Sodium dihydrogen phosphate 7558-80-7 76409 1022 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Sodium fluoride 7681-49-4 75202 537 Wood Inorganic
    Preservative,
    Insecticide
    Sodium fluosilicate 16893-85-9 75306 538 Insecticide Inorganic
    Sodium hexametaphosphate 10124-56-8 76402 1623 pH Adjustment Inorganic
    Sodium hydrosulfite 7775-14-6 78202 3408 pH Adjustment Inorganic
    Sodium hydroxide 1310-73-2 75603 362 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Sodium hypobromite NA 1442 NA 214 NA 213 Microbiocide Inorganic
    Sodium hypochlorite 7681-52-9 14703 539 Microbiocide, Inorganic
    Water
    Treatment,
    Nematicide
    Sodium hypophosphate 13721-43-2 NA 848 3409 N/A Inorganic
    Sodium hypophosphite 7681-53-0 NA 849 3410 N/A Inorganic
    Sodium iodide 7681-82-5 75702 NA 695 N/A Inorganic
    Sodium metabisulfite 7681-57-4 NA 191 NA 190 Fungicide Inorganic
    Sodium metaborate 7775-19-1 11104 689 Insecticide Inorganic
    Sodium metaborate octahydrate NA 1045 NA 154 4012 Insecticide Inorganic
    Sodium metaborate NA 1046 NA 154 4013 Insecticide Inorganic
    tetrahydrate
    Sodium metasilicate 6834-92-0 72604 940 Insecticide, Inorganic
    Adjuvant,
    Fungicide,
    Microbiocide
    Sodium metasilicate, 6834-92-0 72604 1840 Insecticide, Inorganic
    anhydrous Adjuvant,
    Fungicide,
    Microbiocide
    Sodium molybdate 7631-95-0 NA 855 1761 N/A Inorganic
    Sodium nitrate 7631-99-4 76104 696 Rodenticide, Inorganic
    Microbiocide
    Sodium nitrite 7632-00-0 76204 2862 Rodenticide, Inorganic
    Microbiocide
    Sodium oxalate 62-76-0 9604 NA 111 Microbiocide Inorganic
    Sodium pentaborate 11139-65-4 NA 862 1347 Insecticide, Inorganic
    Plant Growth
    Regulator
    Sodium perborate 2092204 ##### 3429 Insecticide Inorganic
    Sodium perborate (NaBO3) 10486-00-7 11108 NA 115 Insecticide Inorganic
    tetrahydrate
    Sodium permanganate 10101-50-5 NA 145 3430 N/A Inorganic
    Sodium peroxide (Na2(O2)) 1313-60-6 63606 NA 526 Microbiocide, Inorganic
    Fungicide,
    Herbicide,
    Rodenticide
    Sodium persulfate 7775-27-1 63603 2336 N/A Inorganic
    Sodium phosphate 7558-79-4 76403 1790 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Sodium phosphate, monobasic 7558-80-7 76409 3433 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Sodium polysulfide 1344-08-7 6902 541 Insecticide, Inorganic
    Fungicide
    Sodium pyroarsenate 13464-42-1 13401 2864 Wood Inorganic-arsenic,
    Preservative, Heavy metal
    Fungicide
    Sodium selenate 13410-01-0 72002 NA 672 N/A Inorganic
    Sodium sesquicarbonate 533-96-0 73507 1292 pH Adjustment, Inorganic
    Fungicide,
    Microbiocide,
    Herbicide
    Sodium silicate 1344-09-8 72603 2865 Insecticide, Inorganic
    Adjuvant,
    Fungicide,
    Microbiocide
    Sodium silicoaluminate NA 1005 NA 868 2866 Adjuvant Inorganic
    Sodium silver thiosulfate NA 1398 NA 197 NA 196 Herbicide Inorganic-Silver,
    Heavy metal
    Sodium sulfate 7757-82-6 5604 1532 Insecticide, Inorganic
    Herbicide
    Sodium sulfide 1313-82-2 NA 214 NA 213 N/A Inorganic
    Sodium sulfite 7757-83-7 78203 1635 Fungicide Inorganic
    Sodium tetraborate (anhydrous) 1330-43-4 11112 5054 Insecticide, Inorganic
    Herbicide,
    Molluscicide
    Sodium tetraborate 11130-12-4 NA 871 1808 Insecticide Inorganic
    (pentahydrate)
    Sodium tetrathiocarbonate 7345-69-9 ##### 2273 Fumigant, Inorganic
    Fungicide,
    Nematicide
    Sodium thioarsenate 17367-56-5 13507 NA 128 N/A Inorganic-arsenic,
    (Na3AsO3S) Heavy metal
    Sodium thiocyanate 540-72-7 68202 848 Herbicide Inorganic
    Sodium thiosulfate 7772-98-7 80104 332 Insecticide, Inorganic
    Fungicide,
    Herbicide
    Sodium tripolyphosphate 7758-29-4 76404 1024 pH Adjustment Inorganic
    Sulfur 7704-34-9 77501 560 Fungicide, Inorganic
    Insecticide
    Sulfur chloride 10025-67-9 NA 116 3461 N/A Inorganic
    Sulfur dichloride 10545-99-0 NA 915 3462 N/A Inorganic
    Sulfur dioxide 2024422 77601 561 Dessicant Inorganic
    Sulfuric acid 7664-93-9 78001 442 Herbicide, Inorganic
    Dessicant,
    Fungicide,
    Microbiocide,
    pH Adjustment
    Sulfuryl chloride 7791-25-5 78002 NA 721 N/A Inorganic
    Sulfuryl fluoride 2699-79-8 78003 618 Fumigant Inorganic
    Talc 14807-96-6 NA 923 2911 N/A Inorganic
    Tetracopper calcium 1336-15-8 23502 NA 187 Fungicide Inorganic-Copper
    oxychloride
    Tetrapotassium pyrophosphate 7320-34-5 76408 1918 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Tetrasodium pyrophosphate 7722-88-5 76405 3474 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Thallium(I) sulfate 7446-18-6 80001 NA 35 Rodenticide Inorganic, Heavy
    metal
    Titanium dioxide 13463-67-7 NA 954 2942 N/A Inorganic
    Titanium sulfate 13825-74-6 NA 111 3476 N/A Inorganic
    Tricopper dichloride 7076-63-3 ##### NA 152 Microbiocide Dithiocarbamate,
    dimethyldithiocarbamate Inorganic-Copper
    Tripotassium phosphate 7778-53-2 76407 1055 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Trisodium phosphate 7601-54-9 76406 1579 pH Adjustment, Inorganic
    Fungicide,
    Herbicide,
    Microbiocide
    Urea 57-13-6 85702 662 Microbiocide, Inorganic
    Fungicide
    Urea dihydrogen sulfate 21351-39-3 ##### 2270 Plant Growth Inorganic
    Regulator,
    Herbicide
    Vermiculite NA 778 NA 140 2983 N/A Inorganic
    Water NA 557 NA 101 2987 Solvent Inorganic
    Zinc 7440-66-6 ##### 2310 Herbicide Inorganic- Zinc
    Zinc
    2,4,5-trichlorophenate 136-24-3 64221 NA 546 N/A Chlorinated Phenol,
    Inorganic-Zinc
    Zinc 2-ethyl hexoate 136-53-8 41203 3509 N/A Inorganic-Zinc
    Zinc 2-pyridinethiol-1-oxide 13463-41-7 88002 2128 Microbiocide Inorganic-Zinc
    Zinc 8-quinolinolate 13978-85-3 24005 NA 196 Fungicide, Inorganic-zinc
    Microbiocide
    Zinc abietate 6798-76-1 NA 112 3506 N/A Inorganic-Zinc
    Zinc arsenate 13464-44-3 13301 NA 125 Herbicide, Inorganic-Arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Zinc
    Zinc arsenite 28837-97-0 13604 NA 130 Herbicide, Inorganic-Arsenic,
    Insecticide, Inorganic-Zinc,
    Rodenticide Heavy metal
    Zinc bacitracin 1405-89-6 6309 NA 87 Microbiocide Inorganic-Zinc
    Zinc carbonate 3486-35-9 NA 102 3507 N/A Inorganic-Zinc
    Zinc chloride 7646-85-7 87801 624 Microbiocide Inorganic-Zinc
    Zinc dehydroabietylammonium 53404-92-5 4211 NA 75 Fungicide, Inorganic-Zinc
    2-ethylhexanoate Microbiocide
    Zinc dodecyl benzene sulfonate 12068-16-5 NA 112 3508 Microbiocide, Soap, Inorganic-Zinc
    Adjuvant,
    Fungicide,
    Insecticide
    Zinc fluosilicate 16871-71-9 75307 1019 Insecticide Inorganic-Zinc
    Zinc formate 557-41-5 87802 NA 838 N/A Inorganic-Zinc
    Zinc hydroxide 20427-58-1 88501 3510 N/A Inorganic-Zinc
    Zinc isodecanoate 30304-30-4 41222 NA 355 N/A Inorganic-Zinc
    Zinc isononanoate 5398-80-6 41212 NA 353 N/A Inorganic-Zinc
    Zinc isooctanoate 84082-93-9 41205 NA 351 N/A Inorganic-Zinc
    Zinc mercury chromate 22323-45-1 21004 NA 170 Fungicide Inorganic-Mercury,
    Inorganic-
    chromium(VI),
    Inorganic-Zinc,
    Heavy metal
    Zinc naphthenate 12001-85-3 88301 1111 Wood Inorganic-Zinc
    Preservative,
    Insecticide,
    Fungicide, Dog
    and Cat
    Repellent
    Zinc neodecanoate 27253-29-8 97502 NA 853 N/A Inorganic-Zinc
    Zinc oxide 1314-13-2 88502 666 Fungicide, Inorganic-Zinc
    Adjuvant
    Zinc petroleum (C20-C30) 68989-17-3 88503 NA 841 N/A Inorganic-Zinc
    sulfonate
    Zinc phenol sulfonate 127-82-2 89002 NA 842 N/A Inorganic-Zinc
    Zinc phosphide 1314-84-7 88601 626 Rodenticide Inorganic-Zinc
    Zinc resinate 9010-69-9 77001 NA 712 N/A Inorganic-Zinc
    Zinc silicate NA 1318 8103 NA 176 Microbiocide Inorganic-Zinc
    Zinc stearate 557-05-1 77002 3511 N/A Inorganic-Zinc
    Zinc sulfate 7733-02-0 89001 667 Microbiocide, Inorganic-Zinc
    Herbicide
    Zinc sulfate, anhydrous 7733-02-0 89001 1852 Microbiocide, Inorganic-Zinc
    Herbicide
    Zinc sulfate, basic 68813-94-5 89101 NA 843 N/A Inorganic-Zinc
    Zinc sulfate, monohydrate 7446-19-7 ##### 2995 Herbicide Inorganic-Zinc
    Zinc trichlorophenate 30143-22-7 64213 NA 543 Microbiocide Chlorinated Phenol,
    Inorganic-Zinc
    Zineb 12122-67-7 14506 627 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Zineb-ethylene thiuram NA 1465 NA 217 NA 216 Fungicide Dithiocarbamate,
    disulfide adduct Inorganic-Zinc
    Ziram 137-30-4 34805 629 Fungicide, Dithiocarbamate,
    Microbiocide, Inorganic-Zinc
    Dog and Cat
    Repellent
    Ziram, cyclohexylamine 16509-79-8 34806 1328 Dog and Cat Dithiocarbamate,
    complex Repellent, Inorganic-Zinc
    Fungicide
    (3-Ethoxypropyl)mercury 6012-84-6 ##### NA 147 Fungicide Organomercury,
    bromide Heavy metal
    (3-Hydroxy-2- 69653-69-6 ##### NA 153 N/A Organomercury,
    methoxypropyl)mercuric Heavy metal
    acetate
    10,10′-Oxybisphenoxyarsine 58-36-6 12601 1402 Fungicide, Organoarsenic,
    Microbiocide Heavy metal
    2-(acetoxymercuri)ethanol 4665-55-8 41501 NA 356 N/A Organomercury,
    Heavy metal
    3-(Hydroxymercuri)-4-nitro-o- 53404-55-0 52604 NA 447 Microbiocide Organomercury,
    phenol, sodium salt Heavy metal
    Ammonium arsenate 7784-44-3 13601 2380 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Ammonium dichromate 2149701 68305 NA 607 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Anilinocadmium dilactate 19651-91-3 64601 NA 548 N/A Inorganic-Cadmium,
    Heavy metal
    Arsenic 7440-38-2 NA 121 710 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic acid 7778-39-4 6801 40 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic disulfide 56320-22-0 6901 NA 98 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic pentoxide 1303-28-2 6802 631 Fungicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide,
    Herbicide
    Arsenic sulfide 12612-21-4 6901 NA 99 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic trioxide 1327-53-3 7001 42 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic trisulfide 1303-33-9 6901 NA 97 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenosobenzene 637-03-6 7101 NA 100 N/A Organoarsenic,
    Heavy metal
    Arsonic acid, (4-aminophenyl)- 98-50-0 ##### NA 109 N/A Organoarsenic,
    Heavy metal
    Arsonic acid, ammonium salt 58829-95-1 ##### NA 105 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Wood
    Preservative
    Azocyclotin 41083-11-8 ##### 2408 Insecticide Organotin, Heavy
    metal
    Basic bismuth gallate 99-26-3 98601 NA 860 N/A Heavy metal
    Basic copper arsenate 16102-92-4 ##### NA 132 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Copper
    Basic lead silicate 53466-66-3 48003 NA 417 N/A Inorganic-Lead,
    Heavy metal
    Bis (tributyltin) adipate 7437-35-6 83117 1990 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Bis (tributyltin) sulfide 4808-30-4 83113 1886 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Bis (tributyltin) sulfone NA 970 NA 476 1665 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Bis(tributyltin) 12379-54-3 83101 NA 824 Antifoulant, Organotin, Heavy
    dodecenylsuccinate Microbiocide metal
    Bis(tributyltin) salicylate 22330-14-9 83102 5074 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Bis(tributyltin) succinate 4644-96-6 83103 74 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Bis(tributyltin) sulfosalicylate 4419-22-1 83104 NA 825 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Bis(tripropyltin) oxide 1067-29-4 83201 NA 829 Microbiocide, Organotin, Heavy
    Fungicide metal
    Cacodylic acid 75-60-5 12501 32 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    Cadmium 7440-43-9 NA 460 2438 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium carbonate 513-78-0 12901 93 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium chloride 10108-64-2 12902 94 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium cocoate 72869-63-7 NA 459 3085 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium oxide 1306-19-0 ##### NA 130 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium perborate NA 969 NA 461 3086 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium sebacate 939499 12903 699 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium succinate 141-00-4 12904 92 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium sulfate 10124-36-4 12905 NA 123 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium yellow pigments NA 967 NA 448 2439 N/A Inorganic-Cadmium,
    Heavy metal
    Calcium acid methanearsonate 5902-95-4 13806 101 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    Calcium arsenate 7778-44-1 13501 96 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide,
    Molluscicide
    Calcium arsenite 53404-59-4 13602 NA 129 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Calcium methanearsonate 6423-72-9 13809 NA 136 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    Calcium propanearsonate 126-94-3 13801 NA 133 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    Calomel 10112-91-1 52201 100 Fungicide Inorganic-Mercury,
    Heavy metal
    Chloromethoxy propyl 1319-86-4 18401 887 N/A Organomercury,
    mercuric acetamide Heavy metal
    Chromated zinc chloride NA 1026 87801 1187 Insecticide, Inorganic-
    Herbicide, Chromium(VI),
    Microbiocide Inorganic-Zinc,
    Heavy metal
    Chromic acetate 1066-30-4 21102 NA 172 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Chromic acid 7738-94-5 21101 1188 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Chromic oxide 1308-38-9 21103 NA 173 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Copper arsenate 10103-61-4 22801 NA 178 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Copper
    Copper arsenite 10290-12-7 22401 NA 177 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Copper
    Copper-zinc chromate complex 1344-74-7 21003 163 Fungicide, Inorganic-
    Wood Chromium(VI),
    Preservative Inorganic-Zinc,
    Heavy metal,
    Inorganic-Copper
    Crag turf fungicide 531 12001-20-6 21006 NA 171 Fungicide Inorganic-Cadmium,
    (Cd—Cu—Ca—Zn-Chromate) Inorganic-
    Chromium(VI),
    Inorganic-Zinc,
    Heavy metal
    Cupric acetoarsenite 12002-03-8 22601 2485 Wood Inorganic-arsenic,
    Preservative Heavy metal,
    Inorganic-Copper
    Cyhexatin 13121-70-5 ##### 1638 Insecticide Organotin, Heavy
    metal
    Decafentin 15652-38-7 ##### NA 132 N/A Organotin, Heavy
    metal
    Di(phenylmercuri) ammonium 18467-88-4 66002 NA 551 N/A Organomercury,
    propionate Heavy metal
    Di(phenylmercuric) dodecenyl 27236-65-3 66001 501 Microbiocide, Organomercury,
    succinate Fungicide Heavy metal
    Dibutyltin dichloride 683-18-1 83123 NA 828 N/A Organotin, Heavy
    metal
    Dodecyl ammonium 53404-47-0 13805 857 Herbicide, Organoarsenic,
    methanearsonate Defoliant Heavy metal
    DSMA 144-21-8 13802 251 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    Ethylene oxide condensate of 56573-85-4 NA 126 1864 Antifoulant, Organotin, Heavy
    abietylamine, tributyltin Microbiocide metal
    chloride
    Ethylmercuric phosphate 2235-25-8 41505 357 N/A Organomercury,
    Heavy metal
    Ethylmercurichlorendiimide 2597-93-5 45301 NA 383 N/A Organomercury,
    Heavy metal
    Ethylmercurithiosalicylic acid 148-61-8 78902 NA 724 Fungicide Organomercury,
    Heavy metal
    Ethylmercury
    2,3- 2597-92-4 41507 NA 361 Fungicide Organomercury,
    dihydroxypropylmercaptide Heavy metal
    Ethylmercury acetate 109-62-6 41502 NA 357 Fungicide Organomercury,
    Heavy metal
    Ethylmercury bromide 107-26-6 ##### NA 149 Fungicide Organomercury,
    Heavy metal
    Ethylmercury chloride 107-27-7 41503 NA 358 Fungicide Organomercury,
    Heavy metal
    Ethylmercury 22232-28-6 41504 NA 359 Microbiocide Organomercury,
    pentachlorophenate Chlorinated Phenol,
    Heavy metal
    Fatty acid* - silver complex 24927-67-1 72505 NA 675 Microbiocide, Inorganic-Silver,
    *(100% C8) Fungicide, Heavy metal
    Herbicide
    Fenbutatin-oxide 13356-08-6 ##### 1876 Insecticide Organotin, Heavy
    metal
    Fentin hydroxide 76-87-9 83601 599 Fungicide, Organotin, Heavy
    Molluscicide, metal
    Herbicide
    Hydroxymercuri-o-nitrophenol 30284-78-7 52601 2606 Microbiocide Organomercury,
    Heavy metal
    Hydroxymercuri-o-nitrophenol, 1300-34-1 52602 NA 445 Microbiocide Organomercury,
    sodium salt Heavy metal
    Hydroxymercurichlorophenols 53466-93-6 46002 NA 391 Microbiocide Organomercury,
    Heavy metal
    Hydroxymercuriphenyl 53466-95-8 46003 NA 392 Microbiocide Organomercury,
    ammonium triethanolamine Heavy metal
    Hydroxymercury cresol 12379-66-7 46001 NA 390 Microbiocide Inorganic-Mercury,
    Heavy metal, Phenols
    Lactoxymercuriphenyl 53466-98-1 51901 NA 429 Microbiocide Organomercury,
    ammonium lactate Heavy metal
    Lauric acid, barium cadmium 15337-60-7 NA 118 3676 Adjuvant Inorganic-Cadmium,
    salt Heavy metal
    Lead 7439-92-1 NA 134 2638 N/A Inorganic-Lead,
    Heavy metal
    Lead acetate 301-04-2 48001 NA 415 N/A Inorganic-Lead,
    Heavy metal
    Lead arsenate 7784-40-9 13503 353 Herbicide, Inorganic-arsenic,
    Insecticide, Inorganic-lead,
    Rodenticide Heavy metal
    Lead arsenate, basic 1327-31-7 13502 354 Herbicide, Inorganic-arsenic,
    Insecticide, Inorganic-lead,
    Rodenticide Heavy metal
    Lead metasilicate NA 938 NA 138 1106 N/A Inorganic-Lead,
    Heavy metal
    Lead monoxide 10190-55-3 NA 123 1271 N/A Inorganic-Lead,
    Heavy metal
    Lead naphthenate 61790-14-5 48004 3296 N/A Inorganic-Lead,
    Heavy metal
    Litharge 1317-36-8 48002 NA 416 N/A Inorganic-Lead,
    Heavy metal
    Magnesium arsenate 10103-50-1 13504 NA 126 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Manganese arsenate 7784-38-5 13506 NA 127 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Mercuric acetate 1600-27-7 52104 NA 441 N/A Inorganic-Mercury,
    Heavy metal
    Mercuric chloride 7487-94-7 52001 372 Fungicide Inorganic-Mercury,
    Heavy metal
    Mercuric dimethyl 15415-64-2 34808 709 Microbiocide Inorganic-Mercury,
    dithiocarbamate Heavy metal,
    Dithiocarbamate
    Mercuric iodide 7774-29-0 52003 NA 438 N/A Inorganic-Mercury,
    Heavy metal
    Mercuric oleate 1191-80-6 52105 3276 N/A Inorganic-Mercury,
    Heavy metal
    Mercuric oxide 21908-53-2 52102 955 Fungicide Inorganic-Mercury,
    Heavy metal
    Mercury 7439-97-6 52301 NA 26 N/A Inorganic-Mercury,
    Heavy metal
    Mercury naphthenate 1336-96-5 52101 NA 439 Wood Inorganic-Mercury,
    Preservative, Heavy metal
    Insecticide,
    Fungicide
    Mercury pentanedione 14024-55-6 52103 NA 440 N/A Inorganic-Mercury,
    Heavy metal
    Mercury phenate 588-66-9 52106 NA 442 N/A Inorganic-Mercury,
    Heavy metal
    Metallic silver 7440-22-4 72501 2125 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Methane arsonic acid (MAA) 124-58-3 ##### NA 27 N/A Organoarsenic,
    Heavy metal
    Methoxyethylmercury acetate 151-38-2 41508 NA 362 Fungicide Organomercury,
    Heavy metal
    Methylenebis(thiocyanate) with 76397-81-4 81408 NA 785 Antifoulant, Organotin, Heavy
    TBTO Microbiocide metal
    Methylmercurichlorendimide 5902-79-4 45302 NA 384 N/A Organomercury,
    Heavy metal
    Methylmercury
    2,3- 2597-95-7 51905 NA 433 Fungicide Organomercury,
    dihydroxypropylmercaptide Heavy metal
    Methylmercury 8- 86-85-1 51902 NA 430 Fungicide Organomercury,
    hydroxyquinolinate Heavy metal
    Methylmercury acetate 108-07-6 51903 NA 431 Fungicide Organomercury,
    Heavy metal
    Methylmercury benzoate 3626-13-9 51904 NA 432 Fungicide Organomercury,
    Heavy metal
    Methylmercury dicyano 502-39-6 51909 454 Fungicide Organomercury,
    diamide Heavy metal
    Methylmercury hydroxide 1184-57-2 51906 NA 434 Fungicide Organomercury,
    Heavy metal
    Methylmercury nitrile 2597-97-9 51907 NA 435 Fungicide Organomercury,
    Heavy metal
    Methylmercury propionate 1460883 51908 NA 436 Fungicide Organomercury,
    Heavy metal
    Monoammonium 2321-53-1 13808 NA 135 Herbicide, Organoarsenic,
    methanearsonate Defoliant Heavy metal
    Monotributyltin salicylate 4342-30-7 83122 NA 827 Antifoulant, Organotin, Heavy
    Microbiocide metal
    MSMA 2163-80-6 13803 34 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    N-(Ethylmercury)-p- 517-16-8 41506 NA 360 Fungicide Organomercury,
    toluenesulfonanilide Heavy metal
    N-(Phenylmercuri) urea 2279-64-3 ##### NA 160 Herbicide Organomercury,
    Heavy metal
    N- 5980-82-5 66009 NA 556 Fungicide Organomercury,
    (Phenylmercuri)ethylenediamine Heavy metal
    o-(Chloromercuri)phenol 90-03-9 ##### NA 135 Microbiocide Organomercury,
    Heavy metal
    o-(Hydroxymercuri)benzoic 5722-59-8 52603 NA 446 Microbiocide Organomercury,
    acid, cyclic anhydride Heavy metal
    Octylammonium 6379-37-9 13804 27 Herbicide, Organoarsenic,
    methanearsonate Defoliant Heavy metal
    p-tert- 53433-01-5 52002 NA 437 Microbiocide Inorganic-Mercury,
    Octylphenoxyethoxyethyl Heavy metal
    dimethyl benzyl ammonium
    mercuric chloride
    Paris green 12002-03-8 22601 460 Wood Inorganic-Arsenic,
    Preservative Inorganic-Copper,
    Heavy metal
    Phenarsazine chloride 578-94-9 63901 1342 N/A Organoarsenic,
    Heavy metal
    Phenarsazine oxide 4095-45-8 12602 NA 122 N/A Organoarsenic,
    Heavy metal
    Phenylmercuriammonium 53404-68-5 66023 NA 567 Fungicide Organomercury,
    propionate Heavy metal
    Phenylmercuric 2- 13302-00-6 66024 NA 568 Fungicide, Organomercury,
    ethylhexanoate Microbiocide Heavy metal
    Phenylmercuric borate 6273-99-0 66005 NA 552 Fungicide, Organomercury,
    Microbiocide Heavy metal
    Phenylmercuric carbonate 53404-69-6 66006 NA 553 Fungicide, Organomercury,
    Microbiocide Heavy metal
    Phenylmercuric chloride 100-56-1 66007 NA 554 Fungicide, Organomercury,
    Microbiocide Heavy metal
    Phenylmercuric 32407-99-1 66008 NA 555 Microbiocide, Organomercury,
    dimethyldithiocarbamate Fungicide Dithiocarbamate,
    Heavy metal
    Phenylmercuric formamide 22894-47-9 66010 NA 557 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    Phenylmercuric hydroxide 100-57-2 66011 NA 558 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    Phenylmercuric lactate 122-64-5 66012 1535 Microbiocide, Organomercury,
    Fungicide, Heavy metal
    Herbicide
    Phenylmercuric 5822-97-9 66013 NA 559 Fungicide, Organomercury,
    monoethanolammonium Microbiocide, Heavy metal
    acetate Herbicide
    Phenylmercuric 53404-70-9 66014 NA 560 Fungicide, Organomercury,
    monoethanolammonium lactate Microbiocide, Heavy metal
    Herbicide
    Phenylmercuric naphthenate 31632-68-5 66015 NA 561 Wood Organomercury,
    Preservative, Heavy metal
    Insecticide,
    Fungicide
    Phenylmercuric nitrate 55-68-5 66016 477 Microbiocide, Organomercury,
    Fungicide, Heavy metal
    Herbicide
    Phenylmercuric octanoate 13864-38-5 66025 NA 569 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    Phenylmercuric oleate 104-60-9 66022 853 Microbiocide, Organomercury,
    Fungicide, Heavy metal
    Herbicide
    Phenylmercuric propionate 103-27-5 66018 NA 563 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    Phenylmercuric salicylate 28086-13-7 66019 NA 564 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    Phenylmercuric thiocyanate 16751-55-6 66020 NA 565 Microbiocide, Organomercury,
    Fungicide, Heavy metal
    Herbicide
    Phenylmercuritriethanolammonium 23319-66-6 66021 NA 566 Microbiocide, Organomercury,
    lactate Fungicide, Heavy metal
    Herbicide
    Phenylmercury 8- 14354-56-4 66017 NA 562 Fungicide, Organomercury,
    hydroxyquinolinolate Microbiocide, Heavy metal
    Herbicide
    Phenylmercury benzoate 94-43-9 51900 NA 428 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    PMA 62-38-4 66003 491 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    PMA, other related NA 1106 NA 164 90491 Fungicide, Organomercury,
    Herbicide, Heavy metal
    Microbiocide
    PMAA 53404-67-4 66004 492 Fungicide, Organomercury,
    Microbiocide Heavy metal
    Poly (methylmethacrylate-co- 26354-18-7 83119 5075 Antifoulant, Organotin, Heavy
    tributyltin methacrylate) Microbiocide metal
    Potassium arsenite 10124-50-2 13605 NA 131 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Potassium arsenite 13464-35-2 13605 NA 132 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Potassium chromate 7789-00-6 68301 700 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Potassium hexafluoroarsenate 17029-22-0 ##### NA 160 N/A Inorganic-arsenic,
    Heavy metal
    Potassium mercuric iodide 7783-33-7 52107 NA 443 N/A Inorganic-Mercury,
    Heavy metal
    Pyridylmercuric acetate 1334-77-6 69501 NA 661 N/A Organomercury,
    Heavy metal
    Pyridylmercuric chloride 1334-75-4 69502 NA 662 N/A Organomercury,
    Heavy metal
    Silver acetate 563-63-3 72507 NA 676 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver carbonate 534-16-7 72509 NA 678 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver chloride 7783-90-6 72506 2324 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver copper zeolite 130328-19-7 ##### NA 110 Microbiocide Inorganic-Silver,
    Heavy metal,
    Inorganic-Copper
    Silver fluoride 7775-41-9 72502 NA 674 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver iodide, colloidal 7783-96-2 NA 124 1556 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver nitrate 7761-88-8 72503 2856 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide,
    Plant Growth
    Regulator
    Silver orthophosphate 7784-09-0 72510 NA 679 Microbiocide, Inorganic-Silver,
    (Ag3PO4) Fungicide, Heavy metal
    Herbicide
    Silver oxide (Ag4O4) 1301-96-8 ##### NA 111 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver oxide (Ag4O4) 155645-89-9 ##### NA 111 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver sodium hydrogen NA 1166 72560 NA 164 Microbiocide Inorganic-Silver,
    zirconium phosphate Heavy metal
    (Ag0.18Na0.57H0.25Zr2(PO4)3)
    Silver thiocyanate 1701-93-5 68203 NA 606 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver thiuronium acrylate copolymer 53404-00-5 72701 NA 681 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver zeolite 130328-18-6 ##### NA 125 Microbiocide Inorganic-Silver,
    Heavy metal
    Silver zinc zeolite 130328-20-0 ##### NA 111 Microbiocide Inorganic-Silver,
    Inorganic-Zinc,
    Heavy metal
    Silver, ionic 14701-21-4 NA 169 5150 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Sodium arsenate 13464-38-5 13505 283 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Sodium arsenite 7784-46-5 13603 534 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide,
    Fungicide
    Sodium cacodylate 124-65-2 12502 1673 Herbicide, Organoarsenic,
    Defoliant, Heavy metal
    Rodenticide
    Sodium chromate 2144646 68303 1241 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Sodium dichromate 10588-01-9 68304 3395 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Sodium 54-64-8 78901 NA 723 N/A Organomercury,
    ethylmercurithiosalicylate Heavy metal
    Sodium pyroarsenate 13464-42-1 13401 2864 Wood Inorganic-arsenic,
    Preservative, Heavy metal
    Fungicide
    Sodium silver thiosulfate NA 1398 NA 197 NA 196 Herbicide Inorganic-Silver,
    Heavy metal
    Sodium thioarsenate 17367-56-5 13507 NA 128 N/A Inorganic-arsenic,
    (Na3AsO3S) Heavy metal
    Thallium(I) sulfate 7446-18-6 80001 NA 35 Rodenticide Inorganic, Heavy
    metal
    Tolylmercuric acetate 1300-78-3 ##### NA 150 Fungicide Organomercury,
    Heavy metal
    Tri-n-butyltin maleate 14275-57-1 83118 2185 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin acetate 56-36-0 83105 2097 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin acrylate 13331-52-7 83121 NA 826 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin benzoate 4342-36-3 83106 1114 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin chloride 1461-22-9 83107 1891 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin chloride complex of 56573-85-4 83108 1412 Antifoulant, Organotin, Heavy
    ethylene oxide condensate of Microbiocide metal
    abietylamine
    Tributyltin chloride, NA 1012 NA 970 938 Antifoulant, Organotin, Heavy
    myristylamine salt Microbiocide metal
    Tributyltin fluoride 29131 83112 1030 Antifoulant, Organotin, Heavy
    Microbiocide, metal
    Fungicide
    Tributyltin isopropyl succinate 53404-82-3 83115 1115 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin linoleate 24124-25-2 83109 1116 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin methacrylate 2155-70-6 83120 2179 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin monopropylene 53466-85-6 83110 1985 Antifoulant, Organotin, Heavy
    glycol maleate Microbiocide metal
    Tributyltin neodecanoate 28801-69-6 83111 1035 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin oxide 56-35-9 83001 569 Antifoulant, Organotin, Heavy
    Microbiocide, metal
    Molluscicide,
    Fungicide
    Tributyltin resinate 13387-91-2 83114 1732 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin sulfide 4808-30-4 83113 1352 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Triethanolamine cacodylate 69484-14-6 12503 NA 121 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    Triethanolamine 5902-97-6 13807 NA 134 Herbicide, Organoarsenic,
    methanearsonate Defoliant Heavy metal
    Trimethyltin chloride 1066-45-1 ##### NA 161 N/A Organotin, Heavy
    metal
    Triphenylbismuthine 603-33-8 82801 NA 821 N/A Heavy metal
    Triphenylbismuthine dichloride 594-30-9 82802 NA 822 N/A Heavy metal
    Triphenyltin acetate 900-95-8 ##### NA 153 Fungicide, Organotin, Heavy
    Herbicide metal
    Triphenyltin chloride 639-58-7 ##### NA 153 N/A Organotin, Heavy
    metal
    Triphenyltin fluoride 379-52-2 83602 2212 Antifoulant Organotin, Heavy
    metal
    Tripropyltin methacrylate 4154-35-2 83202 NA 830 N/A Organotin, Heavy
    metal
    Zinc arsenate 13464-44-3 13301 NA 125 Herbicide, Inorganic-Arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Zinc
    Zinc arsenite 28837-97-0 13604 NA 130 Herbicide, Inorganic-Arsenic,
    Insecticide, Inorganic-Zinc,
    Rodenticide Heavy metal
    Zinc mercury chromate 22323-45-1 21004 NA 170 Fungicide Inorganic-Mercury,
    Inorganic-
    chromium(VI),
    Inorganic-Zinc,
    Heavy metal
    Ammonium arsenate 7784-44-3 13601 2380 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic 7440-38-2 NA 121 710 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic acid 7778-39-4 6801 40 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic disulfide 56320-22-0 6901 NA 98 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic pentoxide 1303-28-2 6802 631 Fungicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide,
    Herbicide
    Arsenic sulfide 12612-21-4 6901 NA 99 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic trioxide 1327-53-3 7001 42 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsenic trisulfide 1303-33-9 6901 NA 97 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Arsonic acid, ammonium salt 58829-95-1 ##### NA 105 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Wood
    Preservative
    Basic copper arsenate 16102-92-4 ##### NA 132 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Copper
    Calcium arsenate 7778-44-1 13501 96 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide,
    Molluscicide
    Calcium arsenite 53404-59-4 13602 NA 129 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Copper arsenate 10103-61-4 22801 NA 178 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Copper
    Copper arsenite 10290-12-7 22401 NA 177 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Copper
    Cupric acetoarsenite 12002-03-8 22601 2485 Wood Inorganic-arsenic,
    Preservative Heavy metal,
    Inorganic-Copper
    Lead arsenate 7784-40-9 13503 353 Herbicide, Inorganic-arsenic,
    Insecticide, Inorganic-lead,
    Rodenticide Heavy metal
    Lead arsenate, basic 1327-31-7 13502 354 Herbicide, Inorganic-arsenic,
    Insecticide, Inorganic-lead,
    Rodenticide Heavy metal
    Magnesium arsenate 10103-50-1 13504 NA 126 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Manganese arsenate 7784-38-5 13506 NA 127 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Paris green 12002-03-8 22601 460 Wood Inorganic-Arsenic,
    Preservative Inorganic-Copper,
    Heavy metal
    Potassium arsenite 10124-50-2 13605 NA 131 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Potassium arsenite 13464-35-2 13605 NA 132 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Potassium hexafluoroarsenate 17029-22-0 ##### NA 160 N/A Inorganic-arsenic,
    Heavy metal
    Sodium arsenate 13464-38-5 13505 283 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide
    Sodium arsenite 7784-46-5 13603 534 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal
    Rodenticide,
    Fungicide
    Sodium pyroarsenate 13464-42-1 13401 2864 Wood Inorganic-arsenic,
    Preservative, Heavy metal
    Fungicide
    Sodium thioarsenate 17367-56-5 13507 NA 128 N/A Inorganic-arsenic,
    (Na3AsO3S) Heavy metal
    Zinc arsenate 13464-44-3 13301 NA 125 Herbicide, Inorganic-Arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Zinc
    Zinc arsenite 28837-97-0 13604 NA 130 Herbicide, Inorganic-Arsenic,
    Insecticide, Inorganic-Zinc,
    Rodenticide Heavy metal
    Antimony 7440-36-0 NA 516 2388 N/A Antimony
    Antimony potassium tartrate 28300-74-5 6201 3057 Insecticide Antimony
    Diphenylstibene 2- 5035-58-5 6202 NA 82 Microbiocide Antimony
    ethylhexanoate
    10,10′-Oxybisphenoxyarsine 58-36-6 12601 1402 Fungicide, Organoarsenic,
    Microbiocide Heavy metal
    Arsenosobenzene 637-03-6 7101 NA 100 N/A Organoarsenic,
    Heavy metal
    Arsonic acid, (4-aminophenyl)- 98-50-0 ##### NA 109 N/A Organoarsenic,
    Heavy metal
    Cacodylic acid 75-60-5 12501 32 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    Calcium acid methanearsonate 5902-95-4 13806 101 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    Calcium methanearsonate 6423-72-9 13809 NA 136 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    Calcium propanearsonate 126-94-3 13801 NA 133 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    Dodecyl ammonium 53404-47-0 13805 857 Herbicide, Organoarsenic,
    methanearsonate Defoliant Heavy metal
    DSMA 144-21-8 13802 251 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    Methane arsonic acid (MAA) 124-58-3 ##### NA 27 N/A Organoarsenic,
    Heavy metal
    Monoammonium 2321-53-1 13808 NA 135 Herbicide, Organoarsenic,
    methanearsonate Defoliant Heavy metal
    MSMA 2163-80-6 13803 34 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    Octylammonium 6379-37-9 13804 27 Herbicide, Organoarsenic,
    methanearsonate Defoliant Heavy metal
    Phenarsazine chloride 578-94-9 63901 1342 N/A Organoarsenic,
    Heavy metal
    Phenarsazine oxide 4095-45-8 12602 NA 122 N/A Organoarsenic,
    Heavy metal
    Sodium cacodylate 124-65-2 12502 1673 Herbicide, Organoarsenic,
    Defoliant, Heavy metal
    Rodenticide
    Triethanolamine cacodylate 69484-14-6 12503 NA 121 Herbicide, Organoarsenic,
    Defoliant Heavy metal
    Triethanolamine 5902-97-6 13807 NA 134 Herbicide, Organoarsenic,
    methanearsonate Defoliant Heavy metal
    Calomel 10112-91-1 52201 100 Fungicide Inorganic-Mercury,
    Heavy metal
    Hydroxymercury cresol 12379-66-7 46001 NA 390 Microbiocide Inorganic-Mercury,
    Heavy metal, Phenols
    Mercuric acetate 1600-27-7 52104 NA 441 N/A Inorganic-Mercury,
    Heavy metal
    Mercuric chloride 7487-94-7 52001 372 Fungicide Inorganic-Mercury,
    Heavy metal
    Mercuric dimethyl 15415-64-2 34808 709 Microbiocide Inorganic-Mercury,
    dithiocarbamate Heavy metal,
    Dithiocarbamate
    Mercuric iodide 7774-29-0 52003 NA 438 N/A Inorganic-Mercury,
    Heavy metal
    Mercuric oleate 1191-80-6 52105 3276 N/A Inorganic-Mercury,
    Heavy metal
    Mercuric oxide 21908-53-2 52102 955 Fungicide Inorganic-Mercury,
    Heavy metal
    Mercury 7439-97-6 52301 NA 26 N/A Inorganic-Mercury,
    Heavy metal
    Mercury naphthenate 1336-96-5 52101 NA 439 Wood Inorganic-Mercury,
    Preservative, Heavy metal
    Insecticide,
    Fungicide
    Mercury pentanedione 14024-55-6 52103 NA 440 N/A Inorganic-Mercury,
    Heavy metal
    Mercury phenate 588-66-9 52106 NA 442 N/A Inorganic-Mercury,
    Heavy metal
    p-tert- 53433-01-5 52002 NA 437 Microbiocide Inorganic-Mercury,
    Octylphenoxyethoxyethyl Heavy metal
    dimethyl benzyl ammonium
    mercuric chloride
    Potassium mercuric iodide 7783-33-7 52107 NA 443 N/A Inorganic-Mercury,
    Heavy metal
    Zinc mercury chromate 22323-45-1 21004 NA 170 Fungicide Inorganic-Mercury,
    Inorganic-
    chromium(VI),
    Inorganic-Zinc,
    Heavy metal
    (3-Ethoxypropyl)mercury 6012-84-6 ##### NA 147 Fungicide Organomercury,
    bromide Heavy metal
    (3-Hydroxy-2- 69653-69-6 ##### NA 153 N/A Organomercury,
    methoxypropyl)mercuric Heavy metal
    acetate
    2-(acetoxymercuri)ethanol 4665-55-8 41501 NA 356 N/A Organomercury,
    Heavy metal
    3-(Hydroxymercuri)-4-nitro-o- 53404-55-0 52604 NA 447 Microbiocide Organomercury,
    phenol, sodium salt Heavy metal
    Chloromethoxy propyl 1319-86-4 18401 887 N/A Organomercury,
    mercuric acetamide Heavy metal
    Di(phenylmercuri) ammonium 18467-88-4 66002 NA 551 N/A Organomercury,
    propionate Heavy metal
    Di(phenylmercuric) dodecenyl 27236-65-3 66001 501 Microbiocide, Organomercury,
    succinate Fungicide Heavy metal
    Ethylmercuric phosphate 2235-25-8 41505 357 N/A Organomercury,
    Heavy metal
    Ethylmercurichlorendiimide 2597-93-5 45301 NA 383 N/A Organomercury,
    Heavy metal
    Ethylmercurithiosalicylic acid 148-61-8 78902 NA 724 Fungicide Organomercury,
    Heavy metal
    Ethylmercury
    2,3- 2597-92-4 41507 NA 361 Fungicide Organomercury,
    dihydroxypropylmercaptide Heavy metal
    Ethylmercury acetate 109-62-6 41502 NA 357 Fungicide Organomercury,
    Heavy metal
    Ethylmercury bromide 107-26-6 ##### NA 149 Fungicide Organomercury,
    Heavy metal
    Ethylmercury chloride 107-27-7 41503 NA 358 Fungicide Organomercury,
    Heavy metal
    Ethylmercury 22232-28-6 41504 NA 359 Microbiocide Organomercury,
    pentachlorophenate Chlorinated Phenol,
    Heavy metal
    Hydroxymercuri-o-nitrophenol 30284-78-7 52601 2606 Microbiocide Organomercury,
    Heavy metal
    Hydroxymercuri-o-nitrophenol, 1300-34-1 52602 NA 445 Microbiocide Organomercury,
    sodium salt Heavy metal
    Hydroxymercurichlorophenols 53466-93-6 46002 NA 391 Microbiocide Organomercury,
    Heavy metal
    Hydroxymercuriphenyl 53466-95-8 46003 NA 392 Microbiocide Organomercury,
    ammonium triethanolamine Heavy metal
    Lactoxymercuriphenyl 53466-98-1 51901 NA 429 Microbiocide Organomercury,
    ammonium lactate Heavy metal
    Methoxyethyl mercury chloride 123-88-6 NA 212 NA 211 Fungicide Organomercury
    Methoxyethyl mercury silicate 64491-92-5 NA 208 NA 208 Fungicide Organomercury
    Methoxyethylmercury acetate 151-38-2 41508 NA 362 Fungicide Organomercury,
    Heavy metal
    Methylmercurichlorendimide 5902-79-4 45302 NA 384 N/A Organomercury,
    Heavy metal
    Methylmercury
    2,3- 2597-95-7 51905 NA 433 Fungicide Organomercury,
    dihydroxypropylmercaptide Heavy metal
    Methylmercury 8- 86-85-1 51902 NA 430 Fungicide Organomercury,
    hydroxyquinolinate Heavy metal
    Methylmercury acetate 108-07-6 51903 NA 431 Fungicide Organomercury,
    Heavy metal
    Methylmercury benzoate 3626-13-9 51904 NA 432 Fungicide Organomercury,
    Heavy metal
    Methylmercury dicyano 502-39-6 51909 454 Fungicide Organomercury,
    diamide Heavy metal
    Methylmercury hydroxide 1184-57-2 51906 NA 434 Fungicide Organomercury,
    Heavy metal
    Methylmercury nitrile 2597-97-9 51907 NA 435 Fungicide Organomercury,
    Heavy metal
    Methylmercury propionate 1460883 51908 NA 436 Fungicide Organomercury,
    Heavy metal
    N-(Ethylmercury)-p- 517-16-8 41506 NA 360 Fungicide Organomercury,
    toluenesulfonanilide Heavy metal
    N-(Phenylmercuri) urea 2279-64-3 ##### NA 160 Herbicide Organomercury,
    Heavy metal
    N- 5980-82-5 66009 NA 556 Fungicide Organomercury,
    (Phenylmercuri)ethylenediamine Heavy metal
    o-(Chloromercuri)phenol 90-03-9 ##### NA 135 Microbiocide Organomercury,
    Heavy metal
    o-(Hydroxymercuri)benzoic 5722-59-8 52603 NA 446 Microbiocide Organomercury,
    acid, cyclic anhydride Heavy metal
    Phenylmercuriammonium 53404-68-5 66023 NA 567 Fungicide Organomercury,
    propionate Heavy metal
    Phenylmercuric 2- 13302-00-6 66024 NA 568 Fungicide, Organomercury,
    ethylhexanoate Microbiocide Heavy metal
    Phenylmercuric borate 6273-99-0 66005 NA 552 Fungicide, Organomercury,
    Microbiocide Heavy metal
    Phenylmercuric carbonate 53404-69-6 66006 NA 553 Fungicide, Organomercury,
    Microbiocide Heavy metal
    Phenylmercuric chloride 100-56-1 66007 NA 554 Fungicide, Organomercury,
    Microbiocide Heavy metal
    Phenylmercuric 32407-99-1 66008 NA 555 Microbiocide, Organomercury,
    dimethyldithiocarbamate Fungicide Dithiocarbamate,
    Heavy metal
    Phenylmercuric formamide 22894-47-9 66010 NA 557 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    Phenylmercuric hydroxide 100-57-2 66011 NA 558 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    Phenylmercuric lactate 122-64-5 66012 1535 Microbiocide, Organomercury,
    Fungicide, Heavy metal
    Herbicide
    Phenylmercuric 5822-97-9 66013 NA 559 Fungicide, Organomercury,
    monoethanolammonium Microbiocide, Heavy metal
    acetate Herbicide
    Phenylmercuric 53404-70-9 66014 NA 560 Fungicide, Organomercury,
    monoethanolammonium lactate Microbiocide, Heavy metal
    Herbicide
    Phenylmercuric naphthenate 31632-68-5 66015 NA 561 Wood Organomercury,
    Preservative, Heavy metal
    Insecticide,
    Fungicide
    Phenylmercuric nitrate 55-68-5 66016 477 Microbiocide, Organomercury,
    Fungicide, Heavy metal
    Herbicide
    Phenylmercuric octanoate 13864-38-5 66025 NA 569 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    Phenylmercuric oleate 104-60-9 66022 853 Microbiocide, Organomercury,
    Fungicide, Heavy metal
    Herbicide
    Phenylmercuric propionate 103-27-5 66018 NA 563 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    Phenylmercuric salicylate 28086-13-7 66019 NA 564 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    Phenylmercuric thiocyanate 16751-55-6 66020 NA 565 Microbiocide, Organomercury,
    Fungicide, Heavy metal
    Herbicide
    Phenylmercuritriethanolammonium 23319-66-6 66021 NA 566 Microbiocide, Organomercury,
    lactate Fungicide, Heavy metal
    Herbicide
    Phenylmercury 8- 14354-56-4 66017 NA 562 Fungicide, Organomercury,
    hydroxyquinolinolate Microbiocide, Heavy metal
    Herbicide
    Phenylmercury benzoate 94-43-9 51900 NA 428 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    Phenylmercury nitrate 2227736 NA 209 NA 208 Fungicide Organomercury
    PMA 62-38-4 66003 491 Fungicide, Organomercury,
    Microbiocide, Heavy metal
    Herbicide
    PMA, other related NA 1106 NA 164 90491 Fungicide, Organomercury,
    Herbicide, Heavy metal
    Microbiocide
    PMAA 53404-67-4 66004 492 Fungicide, Organomercury,
    Microbiocide Heavy metal
    Pyridylmercuric acetate 1334-77-6 69501 NA 661 N/A Organomercury,
    Heavy metal
    Pyridylmercuric chloride 1334-75-4 69502 NA 662 N/A Organomercury,
    Heavy metal
    Sodium 54-64-8 78901 NA 723 N/A Organomercury,
    ethylmercurithiosalicylate Heavy metal
    Tolylmercuric acetate 1300-78-3 ##### NA 150 Fungicide Organomercury,
    Heavy metal
    Anilinocadmium dilactate 19651-91-3 64601 NA 548 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium 7440-43-9 NA 460 2438 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium carbonate 513-78-0 12901 93 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium chloride 10108-64-2 12902 94 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium cocoate 72869-63-7 NA 459 3085 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium oxide 1306-19-0 ##### NA 130 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium perborate NA 969 NA 461 3086 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium sebacate 939499 12903 699 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium succinate 141-00-4 12904 92 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium sulfate 10124-36-4 12905 NA 123 N/A Inorganic-Cadmium,
    Heavy metal
    Cadmium yellow pigments NA 967 NA 448 2439 N/A Inorganic-Cadmium,
    Heavy metal
    Crag turf fungicide 531 12001-20-6 21006 NA 171 Fungicide Inorganic-Cadmium,
    (Cd—Cu—Ca—Zn-Chromate) Inorganic-
    Chromium(VI),
    Inorganic-Zinc,
    Heavy metal
    Lauric acid, barium cadmium 15337-60-7 NA 118 3676 Adjuvant Inorganic-Cadmium,
    salt Heavy metal
    Ammonium dichromate 2149701 68305 NA 607 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Chromated zinc chloride NA 1026 87801 1187 Insecticide, Inorganic-
    Herbicide, Chromium(VI),
    Microbiocide Inorganic-Zinc,
    Heavy metal
    Chromic acetate 1066-30-4 21102 NA 172 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Chromic acid 7738-94-5 21101 1188 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Chromic oxide 1308-38-9 21103 NA 173 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Copper-zinc chromate complex 1344-74-7 21003 163 Fungicide, Inorganic-
    Wood Chromium(VI),
    Preservative Inorganic-Zinc,
    Heavy metal,
    Inorganic-Copper
    Crag turf fungicide 531 12001-20-6 21006 NA 171 Fungicide Inorganic-Cadmium,
    (Cd—Cu—Ca—Zn-Chromate) Inorganic-
    Chromium(VI),
    Inorganic-Zinc,
    Heavy metal
    Potassium chromate 7789-00-6 68301 700 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Potassium dichromate 7778-50-9 68302 2167 Wood Inorganic-
    Preservative Chromium(VI)
    Sodium bichromate dihydrate 7789-12-0 68306 3980 Wood Inorganic-
    Preservative Chromium(VI),
    Inorganic
    Sodium chromate 2144646 68303 1241 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Sodium dichromate 10588-01-9 68304 3395 Wood Inorganic-
    Preservative Chromium(VI),
    Heavy metal
    Zinc mercury chromate 22323-45-1 21004 NA 170 Fungicide Inorganic-Mercury,
    Inorganic-
    chromium(VI),
    Inorganic-Zinc,
    Heavy metal
    Acetic acid, copper (2+) salt 142-71-2 NA 697 3013 N/A Inorganic-Copper
    Basic copper arsenate 16102-92-4 ##### NA 132 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Copper
    Bordeaux mixture NA 240 NA 478 80 Fungicide Inorganic-Copper
    Chlorophyllin 11006-34-1 NA 191 NA 190 Fungicide, Inorganic-Copper,
    Microbiocide Botanical
    Copper 7440-50-8 22501 714 Fungicide Inorganic-Copper
    Copper (from triethanolamine 82027-59-6 24403 NA 198 Algaecide Inorganic-Copper
    complex)
    Copper 2-ethylhexanoate 22221-10-9 41201 2235 Fungicide Inorganic-Copper
    Copper 3-phenylsalicylate 1250682 23801 NA 191 N/A Inorganic-Copper
    Copper 8-quinolinoleate 10380-28-6 24002 159 Fungicide, Inorganic-Copper
    Microbiocide
    Copper abietate 10248-55-2 23301 NA 184 Fungicide Inorganic-Copper
    Copper acetate 831632 44002 147 Fungicide Inorganic-Copper
    Copper ammonium acetate NA 1544 NA 225 NA 225 Fungicide Inorganic-Copper
    Copper ammonium carbonate 33113-08-5 22703 1762 Fungicide Inorganic-Copper
    Copper ammonium complex 16828-95-8 22702 3550 Fungicide Inorganic-Copper
    Copper arsenate 10103-61-4 22801 NA 178 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Copper
    Copper arsenite 10290-12-7 22401 NA 177 Herbicide, Inorganic-arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Copper
    Copper as elemental from 50376-91-5 24404 NA 199 N/A Inorganic-Copper
    copper - etidronic acid complex
    Copper beta cyclodextrin NA 1366 NA 193 NA 193 Fungicide Inorganic-Copper
    hydroxide
    Copper bronze powder 7440-50-8 22501 1457 Antifoulant Inorganic-Copper
    Copper carbonate, basic 1184-64-1 22901 60 Fungicide, Inorganic-Copper
    Algaecide,
    Insecticide
    Copper chloride (anhydrous) 1344-67-8 23802 NA 192 N/A Inorganic-Copper
    Copper chloride (dihydrate) 10125-13-0 23701 NA 190 N/A Inorganic-Copper
    Copper citrate 10402-15-0 44005 1406 N/A Inorganic-Copper
    Copper citrate chelate NA 961 NA 387 3547 N/A Inorganic-Copper
    Copper complex with ammonia 67989-88-2 ##### NA 130 Fungicide Inorganic-Copper
    and ethylene diamine
    tetraacetate
    Copper cresylate 12379-42-9 23001 NA 181 Fungicide Inorganic-Copper
    Copper 53404-24-3 41202 NA 349 N/A Inorganic-Copper
    dehydroabietylammonium 2-
    ethylhexanoate
    Copper dihydrazinium sulfate 33271-65-7 50504 753 N/A Inorganic-Copper
    Copper ethanolamine complex 14215-52-2 24409 NA 201 Algaecide Inorganic-Copper
    Copper ethanolamine NA 1044 NA 146 3551 Algaecide Inorganic-Copper
    complexes, mixed
    Copper ethylenediamine 13426-91-0 24407 3549 Herbicide Inorganic-Copper
    complex
    Copper gluconate chelate 814-91-5 23305 3548 N/A Inorganic-Copper
    Copper hydrazinium sulfate 53433-02-6 50501 NA 418 Fungicide Inorganic-Copper
    Copper hydroxide 20427-59-2 23401 151 Fungicide, Inorganic-Copper
    Microbiocide,
    Nematicide
    Copper hydroxide - NA 1017 NA 105 1826 N/A Inorganic-Copper
    triethanolamine complex
    Copper isodecanoate 84082-88-2 41221 NA 354 N/A Inorganic-Copper
    Copper isononanoate 72915-82-3 41211 NA 352 N/A Inorganic-Copper
    Copper isooctanoate 88859-94-3 41204 NA 350 N/A Inorganic-Copper
    Copper lactate 16039-52-4 23302 NA 185 N/A Inorganic-Copper
    Copper linoleate 7721-15-5 23303 1110 N/A Inorganic-Copper
    Copper metaborate 39290-85-2 22802 NA 179 N/A Inorganic-Copper
    Copper monoethanolamine NA 960 NA 384 3552 N/A Inorganic-Copper
    complex
    Copper naphthenate 1338-02-9 23102 153 Wood Inorganic-Copper
    Preservative,
    Insecticide,
    Fungicide, Dog
    and Cat
    Repellent
    Copper naphthenate 1338-02-9 6000 NA 172 Wood Inorganic-Copper
    Preservative,
    Insecticide,
    Fungicide, Dog
    and Cat
    Repellent
    Copper naphthenate 1338-02-9 6300 NA 172 Wood Inorganic-Copper
    Preservative,
    Insecticide,
    Fungicide, Dog
    and Cat
    Repellent
    Copper nitroacetate 22221-12-1 23201 NA 183 N/A Inorganic-Copper
    Copper octanoate 20543-04-8 23306 5225 Fungicide Inorganic-Copper
    Copper oleate 10402-16-1 23304 154 Fungicide Inorganic-Copper
    Copper oxide (ic) 1317-38-0 42401 2231 Fungicide, Inorganic-Copper
    Insecticide
    Copper oxide (ous) 1317-39-1 25601 175 Fungicide, Inorganic-Copper
    Insecticide
    Copper oxychloride 1332-40-7 8001 156 Fungicide Inorganic-Copper
    Copper oxychloride 1332-65-6 23501 NA 186 Fungicide Inorganic-Copper
    (Cu2Cl(OH)3)
    Copper oxychloride sulfate 8012-69-9 23503 158 Fungicide Inorganic-Copper
    Copper oxysulfate 12158-97-3 23504 NA 188 N/A Inorganic-Copper
    Copper oxysulfate 82010-79-5 23504 NA 189 N/A Inorganic-Copper
    Copper pentachlorophenate 15773-35-0 63011 NA 512 Wood Chlorinated Phenol,
    Preservative, Inorganic-Copper
    Microbiocide,
    Algaecide,
    Fungicide
    Copper phosphate 10103-48-7 22902 NA 180 N/A Inorganic-Copper
    Copper phthalocyanine 147-14-8 NA 381 2479 Dye Inorganic-Copper
    Copper pyrophosphate 10102-90-6 69701 NA 663 N/A Inorganic-Copper
    Copper salts of fatty and rosin 9007-39-0 23104 155 Fungicide Inorganic-Copper
    acids
    Copper salts of the acids of tall 61789-22-8 23103 NA 182 N/A Inorganic-Copper
    oil
    Copper silicate 1344-72-5 24301 NA 197 N/A Inorganic-Copper
    Copper sodium sulfate- NA 1023 NA 121 755 N/A Inorganic-Copper
    phosphate complex
    Copper sulfate (anhydrous) 7758-98-7 24408 1778 Fungicide, Inorganic-Copper
    Algaecide,
    Molluscicide
    Copper sulfate (basic) 1344-73-6 8101 162 Fungicide, Inorganic-Copper
    Algaecide,
    Molluscicide
    Copper sulfate (pentahydrate) 7758-99-8 24401 161 Algaecide, Inorganic-Copper
    Fungicide,
    Insecticide,
    Water
    Treatment,
    Molluscicide,
    Nematicide
    Copper sulfate ethylene NA 1036 NA 132 2480 N/A Inorganic-Copper
    diamine
    Copper sulfate, monohydrate 10257-54-2 24402 1789 Fungicide, Inorganic-Copper
    Algaecide,
    Molluscicide
    Copper sulfate, tri-basic NA 1384 NA 195 NA 194 Herbicide, Inorganic-Copper
    Algaecide,
    Fungicide,
    Water
    Treatment
    Copper triethanolamine 68027-59-6 NA 125 1615 Algaecide Inorganic-Copper
    complex
    Copper-zinc chromate complex 1344-74-7 21003 163 Fungicide, Inorganic-
    Wood Chromium(VI),
    Preservative Inorganic-Zinc,
    Heavy metal,
    Inorganic-Copper
    Copper-zinc sulfate complex 55072-57-6 8102 164 Fungicide Inorganic-Zinc,
    Inorganic-Copper
    Copper-zinc sulfate complex, NA 959 NA 382 1751 Fungicide Inorganic-Zinc,
    monohydrate Inorganic-Copper
    Cuprammonium NA 1382 NA 195 NA 194 Fungicide Inorganic-Copper
    Cupric acetoarsenite 12002-03-8 22601 2485 Wood Inorganic-arsenic,
    Preservative Heavy metal,
    Inorganic-Copper
    Cupric ferric subsulfate 12168-20-6 42402 NA 365 Molluscicide Inorganic-Copper
    complex
    Cupric fluosilicate 12062-24-7 75309 NA 692 Insecticide Inorganic-Copper
    Cupric gluconate 527-09-3 24405 3117 Fungicide Inorganic-Copper
    Cupric nitrate 3251-23-8 76102 3118 N/A Inorganic-Copper
    Cuprous and cupric oxide, 82010-82-0 42403 NA 366 N/A Inorganic-Copper
    mixed
    Cuprous chloride (Cu2Cl2) 7758-89-6 ##### 5597 Fungicide Inorganic-Copper
    Cuprous iodide 7681-65-4 ##### NA 902 N/A Inorganic-Copper
    Cuprous sulfide 22205-45-4 ##### NA 124 N/A Inorganic-Copper
    Cuprous thiocyanate 1111-67-7 25602 2108 Microbiocide Inorganic-Copper
    Device (swimming pool NA 1504 NA 222 NA 222 Algaecide Inorganic-Copper
    algaecide, copper generating)
    no guarantee required
    Dihydrogen 54453-03-1 24406 NA 200 N/A Inorganic-Copper
    {ethylenediaminetetraacetato(4-)}
    cuprate(2-)
    Disodium EDTA-copper 14025-15-1 NA 296 3173 N/A Inorganic-Copper
    EDTA diammonium copper 7379-26-2 39117 1613 Algaecide Inorganic-Copper
    salt
    EDTA, copper complex 12276-01-6 39105 1135 Algaecide Inorganic-Copper
    Lignin sulfonic acid, copper NA 933 NA 126 1925 N/A Inorganic-Copper
    salt
    Malachite (copper equivalent 1319-53-5 ##### NA 155 N/A Inorganic-Copper
    57%)
    Mixed copper chelates or NA 1437 NA 213 NA 212 Fungicide Inorganic-Copper
    complex blend of copper salts
    N-(2-hydroxyethyl) ethylene NA 1025 NA 122 1130 N/A Inorganic-Copper
    diamine triacetic acid, copper
    salt
    Neodecanoic acid, copper salt 50315-14-5 97503 NA 854 N/A Inorganic-Copper
    Paris green 12002-03-8 22601 460 Wood Inorganic-Arsenic,
    Preservative Inorganic-Copper,
    Heavy metal
    Silver copper zeolite 130328-19-7 ##### NA 110 Microbiocide Inorganic-Silver,
    Heavy metal,
    Inorganic-Copper
    Tetracopper calcium 1336-15-8 23502 NA 187 Fungicide Inorganic-Copper
    oxychloride
    Tricopper dichloride 7076-63-3 ##### NA 152 Microbiocide Dithiocarbamate,
    dimethyldithiocarbamate Inorganic-Copper
    Azocyclotin 41083-11-8 ##### 2408 Insecticide Organotin, Heavy
    metal
    Bis (tributyltin) adipate 7437-35-6 83117 1990 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Bis (tributyltin) sulfide 4808-30-4 83113 1886 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Bis (tributyltin) sulfone NA 970 NA 476 1665 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Bis(tributyltin) 12379-54-3 83101 NA 824 Antifoulant, Organotin, Heavy
    dodecenylsuccinate Microbiocide metal
    Bis(tributyltin) salicylate 22330-14-9 83102 5074 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Bis(tributyltin) succinate 4644-96-6 83103 74 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Bis(tributyltin) sulfosalicylate 4419-22-1 83104 NA 825 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Bis(tripropyltin) oxide 1067-29-4 83201 NA 829 Microbiocide, Organotin, Heavy
    Fungicide metal
    Cyhexatin 13121-70-5 ##### 1638 Insecticide Organotin, Heavy
    metal
    Decafentin 15652-38-7 ##### NA 132 N/A Organotin, Heavy
    metal
    Dibutyltin dichloride 683-18-1 83123 NA 828 N/A Organotin, Heavy
    metal
    Ethylene oxide condensate of 56573-85-4 NA 126 1864 Antifoulant, Organotin, Heavy
    abietylamine, tributyltin Microbiocide metal
    chloride
    Fenbutatin-oxide 13356-08-6 ##### 1876 Insecticide Organotin, Heavy
    metal
    Fentin hydroxide 76-87-9 83601 599 Fungicide, Organotin, Heavy
    Molluscicide, metal
    Herbicide
    Methylenebis(thiocyanate) with 76397-81-4 81408 NA 785 Antifoulant, Organotin, Heavy
    TBTO Microbiocide metal
    Monotributylin salicylate 4342-30-7 83122 NA 827 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Poly (methylmethacrylate-co- 26354-18-7 83119 5075 Antifoulant, Organotin, Heavy
    tributyltin methacrylate) Microbiocide metal
    Tin Acrylate Polymers RC 626 NA 1444 NA 214 NA 213 Antifoulant Organotin
    & RC 627
    Tri-n-butyltin maleate 14275-57-1 83118 2185 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin acetate 56-36-0 83105 2097 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin acrylate 13331-52-7 83121 NA 826 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin benzoate 4342-36-3 83106 1114 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin chloride 1461-22-9 83107 1891 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin chloride complex of 56573-85-4 83108 1412 Antifoulant, Organotin, Heavy
    ethylene oxide condensate of Microbiocide metal
    abietylamine
    Tributyltin chloride, NA 1012 NA 970 938 Antifoulant, Organotin, Heavy
    myristylamine salt Microbiocide metal
    Tributyltin fluoride 29131 83112 1030 Antifoulant, Organotin, Heavy
    Microbiocide, metal
    Fungicide
    Tributyltin isopropyl succinate 53404-82-3 83115 1115 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin linoleate 24124-25-2 83109 1116 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin methacrylate 2155-70-6 83120 2179 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin monopropylene 53466-85-6 83110 1985 Antifoulant, Organotin, Heavy
    glycol maleate Microbiocide metal
    Tributyltin naphthenate 85409-17-2 NA 211 NA 210 Fungicide Organotin
    Tributyltin neodecanoate 28801-69-6 83111 1035 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin oxide 56-35-9 83001 569 Antifoulant, Organotin, Heavy
    Microbiocide, metal
    Molluscicide,
    Fungicide
    Tributyltin resinate 13387-91-2 83114 1732 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Tributyltin sulfide 4808-30-4 83113 1352 Antifoulant, Organotin, Heavy
    Microbiocide metal
    Trimethyltin chloride 1066-45-1 ##### NA 161 N/A Organotin, Heavy
    metal
    Triphenyltin acetate 900-95-8 ##### NA 153 Fungicide, Organotin, Heavy
    Herbicide metal
    Triphenyltin chloride 639-58-7 ##### NA 153 N/A Organotin, Heavy
    metal
    Triphenyltin fluoride 379-52-2 83602 2212 Antifoulant Organotin, Heavy
    metal
    Tripropyltin methacrylate 4154-35-2 83202 NA 830 N/A Organotin, Heavy
    metal
    Basic lead silicate 53466-66-3 48003 NA 417 N/A Inorganic-Lead,
    Heavy metal
    Lead 7439-92-1 NA 134 2638 N/A Inorganic-Lead,
    Heavy metal
    Lead acetate 301-04-2 48001 NA 415 N/A Inorganic-Lead,
    Heavy metal
    Lead arsenate 7784-40-9 13503 353 Herbicide, Inorganic-arsenic,
    Insecticide, Inorganic-lead,
    Rodenticide Heavy metal
    Lead arsenate, basic 1327-31-7 13502 354 Herbicide, Inorganic-arsenic,
    Insecticide, Inorganic-lead,
    Rodenticide Heavy metal
    Lead metasilicate NA 938 NA 138 1106 N/A Inorganic-Lead,
    Heavy metal
    Lead monoxide 10190-55-3 NA 123 1271 N/A Inorganic-Lead,
    Heavy metal
    Lead naphthenate 61790-14-5 48004 3296 N/A Inorganic-Lead,
    Heavy metal
    Litharge 1317-36-8 48002 NA 416 N/A Inorganic-Lead,
    Heavy metal
    Alkyl*-1-(2-aminoethyl)-2- NA 1188 46606 NA 167 Microbiocide Inorganic-Nickel,
    imidazoline acetate-nickel Imidazoline
    sulfate complex
    Maneb and nickel sulfate 8005-46-7 ##### NA 158 Fungicide Dithiocarbamate,
    hexahydrate (014505 + 050505) Inorganic-Nickel
    Nickel 7440-02-0 NA 121 762 N/A Inorganic-Nickel
    Nickel diethyl hexyl acid NA 928 NA 53 3696 N/A Inorganic-Nickel
    phosphate complex
    Nickel sulfate (anhydrous) 7786-81-4 50508 NA 420 Fungicide Inorganic-Nickel
    Nickel sulfate hexahydrate 10101-97-0 50505 NA 419 Fungicide Inorganic-Nickel
    Fatty acid*-silver complex 24927-67-1 72505 NA 675 Microbiocide, Inorganic-Silver,
    *(100% C8) Fungicide, Heavy metal
    Herbicide
    Metallic silver 7440-22-4 72501 2125 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver acetate 563-63-3 72507 NA 676 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver carbonate 534-16-7 72509 NA 678 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver chloride 7783-90-6 72506 2324 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver copper zeolite 130328-19-7 ##### NA 110 Microbiocide Inorganic-Silver,
    Heavy metal,
    Inorganic-Copper
    Silver fluoride 7775-41-9 72502 NA 674 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver iodide, colloidal 7783-96-2 NA 124 1556 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver nitrate 7761-88-8 72503 2856 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide,
    Plant Growth
    Regulator
    Silver orthophosphate 7784-09-0 72510 NA 679 Microbiocide, Inorganic-Silver,
    (Ag3PO4) Fungicide, Heavy metal
    Herbicide
    Silver oxide (Ag4O4) 1301-96-8 ##### NA 111 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver oxide (Ag4O4) 155645-89-9 ##### NA 111 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver sodium hydrogen NA 1166 72560 NA 164 Microbiocide Inorganic-Silver,
    zirconium phosphate Heavy metal
    (Ag0.18Na0.57H0.25Zr2(PO4)3)
    Silver thiocyanate 1701-93-5 68203 NA 606 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Silver thiuronium acrylate co- 53404-00-5 72701 NA 681 Microbiocide, Inorganic-Silver,
    polymer Fungicide, Heavy metal
    Herbicide
    Silver zeolite 130328-18-6 ##### NA 125 Microbiocide Inorganic-Silver,
    Heavy metal
    Silver zinc zeolite 130328-20-0 ##### NA 111 Microbiocide Inorganic-Silver,
    Inorganic-Zinc,
    Heavy metal
    Silver, ionic 14701-21-4 NA 169 5150 Microbiocide, Inorganic-Silver,
    Fungicide, Heavy metal
    Herbicide
    Sodium silver thiosulfate NA 1398 NA 197 NA 196 Herbicide Inorganic-Silver,
    Heavy metal
    2-Mercaptobenzothiazole, zinc 155-04-4 51705 1449 Fungicide, Mercaptobenzothiazole,
    salt Microbiocide Inorganic-Zinc
    5-Chloro-2- 53404-93-6 51709 NA 427 Microbiocide, Mercaptobenzothiazole,
    mercaptobenzothiazole, zinc Fungicide Inorganic-Zinc
    salt
    Boric acid(H4B6O11), zinc 12447-61-9 ##### 5094 Fungicide Inorganic-Zinc
    salt(1:2)
    Calcium-zinc LN 193 NA 653 NA 120 3871 N/A Inorganic-Zinc
    (complex)
    Chromated zinc chloride NA 1026 87801 1187 Insecticide, Inorganic-
    Herbicide, Chromium(VI),
    Microbiocide Inorganic-Zinc,
    Heavy metal
    Copper-zinc chromate complex 1344-74-7 21003 163 Fungicide, Inorganic-
    Wood Chromium(VI),
    Preservative Inorganic-Zinc,
    Heavy metal,
    Inorganic-Copper
    Copper-zinc sulfate complex 55072-57-6 8102 164 Fungicide Inorganic-Zinc,
    Inorganic-Copper
    Copper-zinc sulfate complex, NA 959 NA 382 1751 Fungicide Inorganic-Zinc,
    monohydrate Inorganic-Copper
    Crag turf fungicide 531 12001-20-6 21006 NA 171 Fungicide Inorganic-Cadmium,
    (Cd—Cu—Ca—Zn-Chromate) Inorganic-
    Chromium(VI),
    Inorganic-Zinc,
    Heavy metal
    EDTA, disodium zinc salt 14025-21-9 NA 274 3189 N/A Inorganic-Zinc
    Lignin sulfonic acid, zinc salt NA 1014 NA 102 1768 N/A Inorganic-Zinc
    Lignin sulfonic acid, zinc, NA 1030 NA 126 1771 N/A Inorganic-Zinc
    manganese & iron salts
    Mancozeb 2233100 14504 211 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Metiram 9006-42-2 14601 493 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    o-Phenylphenol, alkyl* amine- 82010-74-0 64107 NA 533 Microbiocide Phenols, Inorganic-
    zinc salt of *(100% C18) Zinc
    Pentachlorophenol, zinc salt 2917-32-0 63008 NA 510 Wood Chlorinated Phenol,
    Preservative, Inorganic-Zinc
    Microbiocide,
    Algaecide,
    Fungicide
    Polyoxin D zinc salt 146659-78-1 ##### NA 129 Fungicide Inorganic-Zinc
    Propineb 12071-83-9 ##### NA 155 Fungicide, Dithiocarbamate,
    Microbiocide Inorganic-Zinc
    Silver zinc zeolite 130328-20-0 ##### NA 111 Microbiocide Inorganic-Silver,
    Inorganic-Zinc,
    Heavy metal
    Zinc 7440-66-6 ##### 2310 Herbicide Inorganic- zinc
    Zinc
    2,4,5-trichlorophenate 136-24-3 64221 NA 546 N/A Chlorinated Phenol,
    Inorganic-Zinc
    Zinc 2-ethyl hexoate 136-53-8 41203 3509 N/A Inorganic-Zinc
    Zinc 2-pyridinethiol-1-oxide 13463-41-7 88002 2128 Microbiocide Inorganic-Zinc
    Zinc 8-quinolinolate 13978-85-3 24005 NA 196 Fungicide, Inorganic-Zinc
    Microbiocide
    Zinc abietate 6798-76-1 NA 112 3506 N/A Inorganic-Zinc
    Zinc arsenate 13464-44-3 13301 NA 125 Herbicide, Inorganic-Arsenic,
    Insecticide, Heavy metal,
    Rodenticide Inorganic-Zinc
    Zinc arsenite 28837-97-0 13604 NA 130 Herbicide, Inorganic-Arsenic,
    Insecticide, Inorganic-Zinc,
    Rodenticide Heavy metal
    Zinc bacitracin 1405-89-6 6309 NA 87 Microbiocide Inorganic-Zinc
    Zinc carbonate 3486-35-9 NA 102 3507 N/A Inorganic-Zinc
    Zinc chloride 7646-85-7 87801 624 Microbiocide Inorganic-Zinc
    Zinc dehydroabietylammonium 53404-92-5 4211 NA 75 Fungicide, Inorganic-Zinc
    2-ethylhexanoate Microbiocide
    Zinc dodecyl benzene sulfonate 12068-16-5 NA 112 3508 Microbiocide, Soap, Inorganic-Zinc
    Adjuvant,
    Fungicide,
    Insecticide
    Zinc fluosilicate 16871-71-9 75307 1019 Insecticide Inorganic-Zinc
    Zinc formate 557-41-5 87802 NA 838 N/A Inorganic-Zinc
    Zinc hydroxide 20427-58-1 88501 3510 N/A Inorganic-Zinc
    Zinc isodecanoate 30304-30-4 41222 NA 355 N/A Inorganic-Zinc
    Zinc isononanoate 5398-80-6 41212 NA 353 N/A Inorganic-Zinc
    Zinc isooctanoate 84082-93-9 41205 NA 351 N/A Inorganic-Zinc
    Zinc mercury chromate 22323-45-1 21004 NA 170 Fungicide Inorganic-Mercury,
    Inorganic-
    chromium(VI),
    Inorganic-Zinc,
    Heavy metal
    Zinc naphthenate 12001-85-3 88301 1111 Wood Inorganic-Zinc
    Preservative,
    Insecticide,
    Fungicide, Dog
    and Cat
    Repellent
    Zinc neodecanoate 27253-29-8 97502 NA 853 N/A Inorganic-Zinc
    Zinc oxide 1314-13-2 88502 666 Fungicide, Inorganic-Zinc
    Adjuvant
    Zinc petroleum (C20-C30) 68989-17-3 88503 NA 841 N/A Inorganic-Zinc
    sulfonate
    Zinc phenol sulfonate 127-82-2 89002 NA 842 N/A Inorganic-Zinc
    Zinc phosphide 1314-84-7 88601 626 Rodenticide Inorganic-Zinc
    Zinc resinate 9010-69-9 77001 NA 712 N/A Inorganic-Zinc
    Zinc silicate NA 1318 8103 NA 176 Microbiocide Inorganic-Zinc
    Zinc stearate 557-05-1 77002 3511 N/A Inorganic-Zinc
    Zinc sulfate 7733-02-0 89001 667 Microbiocide, Inorganic-Zinc
    Herbicide
    Zinc sulfate, anhydrous 7733-02-0 89001 1852 Microbiocide, Inorganic-Zinc
    Herbicide
    Zinc sulfate, basic 68813-94-5 89101 NA 843 N/A Inorganic-Zinc
    Zinc sulfate, monohydrate 7446-19-7 ##### 2995 Herbicide Inorganic-Zinc
    Zinc trichlorophenate 30143-22-7 64213 NA 543 Microbiocide Chlorinated Phenol,
    Inorganic-Zinc
    Zineb 12122-67-7 14506 627 Fungicide Dithiocarbamate,
    Inorganic-Zinc
    Zineb-ethylene thiuram NA 1465 NA 217 NA 216 Fungicide Dithiocarbamate,
    disulfide adduct Inorganic-Zinc
    Ziram 137-30-4 34805 629 Fungicide, Dithiocarbamate,
    Microbiocide, Inorganic-Zinc
    Dog and Cat
    Repellent
    Ziram, cyclohexylamine 16509-79-8 34806 1328 Dog and Cat Dithiocarbamate,
    complex Repellent, Inorganic-Zinc
    Fungicide
    1-butoxy ethoxy-2-propanol 124-16-3 NA 113 3074 N/A Alcohol/Ether
    1-butoxy-2-propanol 5131-86-8 NA 467 3075 Solvent Alcohol/Ether
    1-decanol 112-30-1 79038 1791 Plant Growth Alcohol/Ether
    Regulator
    1-Heptadecanol 1454-85-9 ##### NA 150 N/A Alcohol/Ether
    1-heptanol 111-70-6 NA 205 3222 N/A Alcohol/Ether
    1-hexanol 111-27-3 79047 3229 N/A Alcohol/Ether
    1-Octanol 111-87-5 79037 NA 733 Plant Growth Alcohol/Ether
    Regulator,
    Herbicide
    2,6,8-trimethyl-4-nonanol 123-17-1 NA 144 3303 Adjuvant Alcohol/Ether
    2-(2-Butoxyethoxy)ethanol 112-34-5 11502 NA 117 Solvent Alcohol/Ether,
    Glycol Ether
    2-butoxyethanol 111-76-2 11501 89 Fungicide, Alcohol/Ether
    Microbiocide,
    Solvent
    2-ethoxyethanol 110-80-5 NA 104 2554 Fungicide, Alcohol/Ether
    Microbiocide
    2-Ethyl-1-butanol 97-95-0 ##### NA 148 N/A Alcohol/Ether
    2-ethyl-1-hexanol 10-47-6 NA 251 2560 N/A Alcohol/Ether
    2-Ethyl-1-hexanol 104-76-7 79098 NA 767 Solvent Alcohol/Ether
    2-Phenylcyclohexanol 1444-64-0 65002 NA 550 N/A Alcohol/Ether
    2-Phenylethanol 60-12-8 1503 NA 62 N/A Alcohol/Ether
    3,3,5-trimethyl cyclohexanol 116-02-9 NA 982 3493 N/A Alcohol/Ether
    3-phenoxybenzyl alcohol 13826-35-2 NA 651 2771 N/A Alcohol/Ether
    4-Methyl-2-pentanol 108-11-2 ##### NA 157 N/A Alcohol/Ether
    Alcohols, C4-C12, normal NA 392 NA 713 2067 Solvent, Alcohol/Ether
    Microbiocide
    Alcohols, C6-12 68603-15-6 79029 5072 Microbiocide, Alcohol/Ether
    Solvent
    Alcohols, C8-10 85566-12-7 79059 5073 Microbiocide, Alcohol/Ether
    Solvent
    Alkanols (ave. C6), mixed NA 394 NA 716 1536 Adjuvant Alcohol/Ether
    Alkylaryl polyether alcohol NA 657 NA 121 878 Adjuvant Alcohol/Ether
    Allyl alcohol 107-18-6 68401 3023 Herbicide Alcohol/Ether
    Benzyl alcohol 100-51-6 9502 915 Insecticide, Alcohol/Ether
    Fungicide
    Butyl alcohol 78-92-2 1502 1482 Solvent Alcohol/Ether
    Cetyl alcohol 36653-82-4 1508 2449 N/A Alcohol/Ether
    Cinnamyl alcohol 104-54-1 40512 NA 343 Insecticide Alcohol/Ether
    Cyclobutaneethanol, 1-methyl- 30820-22-5 ##### NA 922 N/A Alcohol/Ether
    2-(1-methylethenyl)-,cis-
    Cyclohexanol 108-93-0 25904 3121 Solvent Alcohol/Ether
    Denatured ethanol NA 1033 NA 129 2102 Solvent Alcohol/Ether
    Dimethyl ether 115-10-6 NA 132 2517 Solvent Alcohol/Ether
    Ethyl alcohol 64-17-5 1501 8 Microbiocide, Alcohol/Ether
    Solvent,
    Adjuvant,
    Molluscicide
    Ethylene oxide 75-21-8 42301 277 Fumigant Alcohol/Ether
    Fatty alcohols (100% C4-C10) NA 126 NA 241 3654 Adjuvant Alcohol/Ether
    Fatty alcohols (55.10% C10, NA 1265 79089 NA 173 Plant Growth Alcohol/Ether
    42.88% C8, 1.01% C6, 1.01% Regulator,
    C12) Adjuvant
    Fatty alcohols (65% C12, 26% 67762-41-8 79056 NA 744 Adjuvant Alcohol/Ether
    C14, 8% C16, 1% C10)
    Hydrocinnamyl alcohol 122-97-4 40511 NA 342 N/A Alcohol/Ether
    i-Nonyl alcohol 3452-97-9 ##### NA 153 N/A Alcohol/Ether
    Isobutyl alcohol 78-83-1 1507 2622 Solvent Alcohol/Ether
    Isodecyl alcohol 25339-17-7 NA 168 3242 Solvent Alcohol/Ether
    Isopropyl alcohol 67-63-0 47501 342 Microbiocide, Alcohol/Ether
    Solvent
    Isostearyl alcohol 27458-93-1 NA 156 2627 Adjuvant Alcohol/Ether
    Lauryl alcohol 112-53-8 1509 2343 Pheromone, Pheromone,
    Adjuvant Alcohol/Ether
    Methanol 67-56-1 53801 1018 Solvent, Alcohol/Ether
    Adjuvant,
    Microbiocide
    Methoxypropanol 107-98-2 NA 90 2675 Solvent Alcohol/Ether
    Myristyl alcohol 112-72-1 1510 2344 Pheromone, Alcohol/Ether
    Fragrance
    n-Butyl alcohol 71-36-3 NA 468 3077 Solvent Alcohol/Ether
    n-Decyl alcohol 112-30-1 79038 3124 Plant Growth Alcohol/Ether
    Regulator
    n-Propoxy propanol 30136-13-1 NA 798 2837 Solvent Alcohol/Ether
    n-Propyl alcohol 71-23-8 47502 1603 Solvent Alcohol/Ether
    Oleyl alcohol 143-28-2 NA 9 3313 Adjuvant Alcohol/Ether
    Propargyl alcohol 107-19-7 68702 NA 609 Breakdown Alcohol/Ether
    product
    Propylene oxide 75-56-9 42501 508 Fumigant Alcohol/Ether
    sec-Butanol 75-65-0 1505 NA 64 Solvent Alcohol/Ether
    Sec-butyl alcohol 78-92-2 1502 3078 Solvent Alcohol/Ether
    Stearyl alcohol 112-92-5 NA 110 2892 Adjuvant Alcohol/Ether
    Tetrahydro furfuryl alcohol 97-99-4 NA 945 3471 Solvent Alcohol/Ether
    (2- 150-39-0 39108 NA 330 Adjuvant Chelating agent
    Hydroxyethyl)ethylenediamine
    triacetic acid
    Dimethamine EDTA NA 167 NA 319 3159 Adjuvant Chelating agent
    EDTA 60-00-4 39101 1702 Adjuvant Chelating agent
    EDTA, ammonium salt 7379-26-2 39117 889 Adjuvant Chelating agent
    EDTA, diethanolamine salt 68133-37-9 NA 273 3187 Adjuvant Chelating agent
    EDTA, disodium salt 139-33-3 39115 2101 Herbicide, Chelating agent
    Adjuvant
    EDTA, disodium salt 139-33-3 39115 954 Herbicide, Chelating agent
    Adjuvant
    EDTA, iron chelate NA 890 NA 170 3240 Herbicide Chelating agent
    EDTA, monoethanolamine salt 7379-26-2 39117 2013 Adjuvant Chelating agent
    EDTA, monopotassium salt 7379-27-3 39111 NA 331 Adjuvant Chelating agent
    EDTA, potassium salt NA 891 NA 170 3350 Adjuvant Chelating agent
    EDTA, sodium salt 17421-79-3 39103 1757 Adjuvant Chelating agent
    EDTA, tetrapotassium salt 5964-35-2 39118 1054 Adjuvant Chelating agent
    EDTA, tetrasodium salt 64-02-8 39107 759 Adjuvant Chelating agent
    EDTA, trisodium salt 150-38-9 39110 953 Adjuvant Chelating agent
    Ethanolamine 63517-71-5 39116 NA 334 Adjuvant, Chelating agent
    ethylenediaminetetraacetate Fungicide
    N-(2-hydroxyethyl) ethylene 139-89-9 39109 911 Microbiocide, Chelating agent
    diamine triacetic acid, trisodium Adjuvant
    salt
    Nitrilotriacetic acid 139-13-9 NA 228 NA 228 Adjuvant Chelating agent
    Nitrilotriacetic acid, sodium 10042-84-9 ##### NA 121 Adjuvant Chelating agent
    salt
    Sodium N-(2- 53404-54-9 39121 NA 335 Adjuvant Chelating agent
    hydroxyethyl)ethylenediaminetriacetate
    Tetra(monoethanolamine) 53404-52-7 39112 NA 332 Adjuvant, Chelating agent
    ethylenediaminetetraacetate Adjuvant
    Triethylamine EDTA NA 790 NA 146 3486 Adjuvant Chelating agent
    Triethylamine nitrilo triacetate NA 537 NA 978 3487 Adjuvant Chelating agent
    Tripotassium 17572-97-3 39113 1177 Adjuvant Chelating agent
    ethylenediaminetetraacetate
    Trisodium nitrilo triacetate 5064-31-3 39106 1121 Adjuvant Chelating agent
    2,4,5-T, butoxyethanol ester 2545-59-7 82053 819 Herbicide Chlorophenoxy acid
    or ester, Glycol Ether
    2,4-D, butoxyethanol ester 1929-73-3 30053 802 Herbicide Chlorophenoxy acid
    or ester, Glycol Ether
    2-(2-Butoxyethoxy)ethanol 112-34-5 11502 NA 117 Solvent Alcohol/Ether,
    Glycol Ether
    4-(2,4-DB), butoxyethanol 32357-46-3 30853 837 Herbicide Chlorophenoxy acid
    ester or ester, Glycol Ether
    Alkylaryl polyglycol ether NA 319 NA 599 1264 Adjuvant Polyalkyloxy
    Compound, Glycol
    Ether
    Cinoxate 104-28-9 76604 NA 706 N/A Glycol Ether
    Dichlorprop, butoxyethanol 53404-31-2 31453 923 Plant Growth Chlorophenoxy acid
    ester Regulator, or ester, Glycol Ether
    Herbicide
    Diethylene glycol monoethyl 111-90-0 11504 2505 Adjuvant, Glycol Ether
    ether Solvent
    Diethylene glycol monomethyl 111-77-3 42204 2506 Adjuvant, Glycol Ether
    ether Solvent
    Ethoxyethoxyethyl 2,4- 53404-36-7 30058 NA 245 Herbicide Chlorophenoxy acid
    dichlorophenoxyacetate or ester, Glycol Ether
    Ethyl amino benzoate 111-15-9 NA 260 3192 N/A Glycol Ether
    Ethylene glycol, mono-butyl 111-76-2 11501 1880 Solvent, Glycol Ether
    ether Adjuvant
    Haloxyfop-etotyl (unstated 87237-48-7 NA 200 NA 199 Herbicide Aryloxyphenoxy
    stereochemistry) propionic acid,
    Glycol Ether
    MCPA, butoxyethanol ester 19480-43-4 30553 785 Herbicide Chlorophenoxy acid
    or ester, Glycol Ether
    Silvex, butoxyethanol ester 19398-13-1 82553 828 Herbicide Chlorophenoxy acid
    or ester, Glycol Ether
    Triclopyr, butoxyethyl ester 64700-56-7 ##### 2170 Herbicide Chloropyridinyl,
    Glycol Ether
    (Decyl oxy) poly (oxy 9038-29-3 NA 117 3636 Adjuvant Polyalkyloxy
    ethylene) poly (oxy propylene) Compound
    (Octyl oxy) poly (oxyethylene) 61827-84-7 NA 102 3707 Adjuvant Polyalkyloxy
    poly (oxypropylene) Compound
    2,6,8-trimethyl-4-nonyloxy NA 1162 NA 175 5599 Adjuvant Polyalkyloxy
    polyethylene oxyethanol Compound
    4-nonyl phenoxy poly NA 805 NA 149 3698 Soap/Surfactant, Polyalkyloxy
    (ethylene oxy) ethyl phosphate, Adjuvant Compound
    magnesium salt
    a-(p-nonylphenyl)-omega- NA 27 NA 40 2066 Microbiocide Polyalkyloxy
    hydroxypoly (oxyethylene) Compound
    with an average of 4.2 moles of
    ethylene oxide.the nonly group
    is a propylene
    a-(p-nonylphenyl)-omega- NA 28 NA 41 2052 Microbiocide Polyalkyloxy
    hydroxypoly (oxyethylene) Compound
    with an averageof 9-10 moles
    of ethylene oxide
    Alkenoic acid poly oxyalkylene NA 396 NA 718 2364 Adjuvant Polyalkyloxy
    ether & alkyl poly oxyalkylene Compound
    ether
    Alkoxy poly (ethyleneoxy) NA 286 NA 555 1390 Adjuvant, Polyalkyloxy
    ethyl phosphate Soap/Surfactant Compound
    Alkyl (100% C10-C13) oxy NA 288 NA 560 3575 Adjuvant, Polyalkyloxy
    poly (ethylene oxy) ethyl Soap/Surfactant Compound
    phosphate, mono-
    Alkyl (100% C10-C14) oxy 68585-36-4 NA 579 3574 Adjuvant, Polyalkyloxy
    poly (ethylene oxy) ethyl Soap/Surfactant Compound
    phosphate
    Alkyl (100% C11-C15) 68131-40-8 79084 3572 Insecticide, Polyalkyloxy
    phenoxypoly (ethylene oxy) Fungicide, Compound
    ethanol Avicide,
    Adjuvant
    Alkyl (C8,C10) polyglycoside 68515-73-1 NA 154 4015 Adjuvant Polyalkyloxy
    Compound
    Alkyl and alkylaryl poly NA 398 NA 720 1706 Adjuvant Polyalkyloxy
    (oxyethylene) glycols, mixed Compound
    Alkyl aryl alkoxylate NA 314 NA 594 2366 Adjuvant Polyalkyloxy
    Compound
    Alkyl aryl polyoxyalkane ether NA 323 NA 603 2370 Adjuvant Polyalkyloxy
    and free fatty acids Compound
    Alkyl oxy poly (ethyleneoxy) NA 679 NA 125 1715 Adjuvant, Polyalkyloxy
    ethyl phosphate Soap/Surfactant Compound
    Alkyl oxy polyethoxy ethanol NA 306 NA 578 2048 Adjuvant Polyalkyloxy
    Compound
    Alkyl oxy-polyoxyethylene and NA 289 NA 561 2136 Adjuvant Polyalkyloxy
    alkyl phenyloxy- Compound
    polyoxyethylene
    Alkyl phenoxypoly (ethoxy) NA 291 NA 563 1173 Adjuvant Polyalkyloxy
    ethanol Compound
    Alkyl phenyl poly (ethoxy) NA 294 NA 566 1064 Adjuvant Polyalkyloxy
    ethanol Compound
    Alkyl polyethylene glycol ether NA 668 NA 123 1376 Adjuvant, Polyalkyloxy
    Soap/Surfactant Compound
    Alkyl polyoxy alkylene ether NA 295 NA 567 2123 Adjuvant Polyalkyloxy
    Compound
    Alkyl polyoxy ethylene ether, NA 592 NA 107 2014 Adjuvant Polyalkyloxy
    diphosphoric acid ester Compound
    Alkyl polyoxy ethylene ether, NA 296 NA 568 2377 Adjuvant Polyalkyloxy
    free fatty acids Compound
    Alkyl polyoxy ethylene ether, NA 694 NA 127 2015 Adjuvant Polyalkyloxy
    monophosphoric acid ester Compound
    Alkyl polyoxy ethylene ethers, NA 297 NA 569 2158 Adjuvant Polyalkyloxy
    polymerized resins and fatty Compound
    acids
    Alkyl polyoxy ethylene glycols NA 285 NA 554 2051 Adjuvant Polyalkyloxy
    Compound
    Alkylaryl hydroxypoly NA 316 NA 596 2037 Adjuvant Polyalkyloxy
    (oxyethylene) ethanol Compound
    Alkylaryl poly(oxyethylene) NA 315 NA 595 748 Adjuvant Polyalkyloxy
    glycol Compound
    Alkylaryl polyalkoxylated NA 705 NA 129 2174 Adjuvant Polyalkyloxy
    alcohols Compound
    Alkylaryl polyethoxy ethanol NA 714 NA 130 2368 Adjuvant, Polyalkyloxy
    phosphate Soap/Surfactant Compound
    Alkylaryl polyethoxyethanol NA 912 NA 174 5323 Adjuvant Polyalkyloxy
    sulfates Compound
    Alkylaryl polyethylene glycol NA 318 NA 598 2198 Adjuvant, Polyalkyloxy
    ether Soap/Surfactant Compound
    Alkylaryl polyglycol ester NA 1470 NA 218 NA 218 Adjuvant Polyalkyloxy
    Compound
    Alkylaryl polyglycol ether NA 319 NA 599 1264 Adjuvant Polyalkyloxy
    Compound, Glycol
    Ether
    Alkylaryl polyoxy glycol NA 322 NA 602 2369 Adjuvant Polyalkyloxy
    Compound
    Alkylaryl polyoxyethylene NA 320 NA 600 881 Adjuvant Polyalkyloxy
    ether Compound
    Alkylaryl polyoxyethylene NA 321 NA 601 2024 Adjuvant, Polyalkyloxy
    glycol phosphate ester Soap/Surfactant Compound
    Alkylaryl poyloxyethylene NA 671 NA 124 1507 Adjuvant Polyalkyloxy
    ethanol Compound
    Alkylpoly glycol ether NA 292 NA 564 1172 Adjuvant Polyalkyloxy
    Compound
    Allyl oxy poly ethylene glycol NA 279 NA 545 2376 N/A Polyalkyloxy
    monoallyl acetate Compound
    Alpha (para-tert-butyl phenyl)- NA 235 NA 463 1605 Adjuvant Polyalkyloxy
    omega-hydroxypoly Compound
    (oxyethylene)-
    Alpha (para-tert-butylphenyl)- NA 234 NA 462 1786 Adjuvant Polyalkyloxy
    omega-hydroxypoly Compound
    (oxyethylene)
    Alpha-(omega-sec-butyl NA 231 NA 452 1885 Adjuvant Polyalkyloxy
    phenylpoly (oxypropylene))- Compound
    omega-hydroxypoly
    Alpha-(p-(1,1,3,3-tetramethyl NA 609 NA 111 1932 Adjuvant Polyalkyloxy
    butyl) phenyl)-omega-hydroxypoly Compound
    Alpha-(p-nonylphenyl)-omega- NA 745 NA 135 2710 Adjuvant Polyalkyloxy
    hydroxypoly (oxypropylene) Compound
    Alpha-(para-nonyl phenyl)- NA 18 NA 31 1649 Adjuvant Polyalkyloxy
    omega-hydroxypoly Compound
    (oxyethylene)
    Alpha-alkyl (43% C10, NA 684 NA 126 1834 Microbiocide Polyalkyloxy
    30% C14, 12% C12, 10% C16, Compound
    5% C18) poly (oxyethylene)
    poly (oxypropylene) - I2
    complex
    Alpha-alkyl (C10-C12)-omega- NA 307 NA 582 2077 Adjuvant Polyalkyloxy
    hydroxypoly (oxyethylene) Compound
    Alpha-alkyl (C10-C18)- NA 301 NA 573 1700 Adjuvant Polyalkyloxy
    omega-hydroxypoly Compound
    (oxyethylene) sulfate
    150 solvent neutral BP 901 NA 747 NA 136 2724 Insecticide Petroleum derivative
    base oil
    Alkylated aromatic petroleum 68919-17-5 54001 NA 451 Insecticide, Petroleum derivative
    oil Adjuvant
    Amoco 6342 NA 715 NA 131 2384 N/A Petroleum derivative
    Anthracene oil 120-12-7 NA 185 NA 184 Insecticide, Petroleum derivative
    Herbicide,
    Rodenticide
    Aromatic 100 NA 269 NA 524 2394 Insecticide, Petroleum derivative
    Solvent
    Aromatic 150 NA 716 NA 131 2395 Insecticide, Petroleum derivative
    Solvent
    Aromatic 200 64742-94-5 6602 2396 Insecticide, Petroleum derivative
    Solvent
    Asphalt solids 8052-42-4 22001 1140 Pruning Aid Petroleum derivative
    Bitumen 8052-42-4 22002 NA 171 N/A Petroleum derivative
    Candle wax NA 227 NA 440 2443 N/A Petroleum derivative
    Chevron 100 neutral oil 68602-80-2 6601 2456 Insecticide Petroleum derivative
    Chevron base oil “C” NA 224 NA 431 2455 Insecticide Petroleum derivative
    Chevron solvent 425 NA 722 NA 132 2457 Solvent Petroleum derivative
    Coal tar distillate boiling 65996-91-0 6101 5042 Insecticide, Petroleum derivative
    between 270-300 deg C. Herbicide
    Coal tar hydrocarbons 8007-45-2 22003 1719 Wood Petroleum derivative
    Preservative
    Coal tar neutral oils and coal 65996-82-9 25001 144 Insecticide, Petroleum derivative
    tar acid combinations Herbicide
    Coal tar phenols 1319-77-3 22101 1720 N/A Petroleum derivative,
    Phenols
    Coal tar pitch >351 65996-93-2 ##### NA 106 Insecticide Petroleum derivative
    deg. C.(AWPI)
    Conoco LPA NA 195 NA 386 2478 N/A Petroleum derivative
    Creosote 8001-58-9 25004 171 Wood Petroleum derivative
    Preservative
    Creosote oil (note: derived 61789-28-4 25003 NA 203 Wood Petroleum derivative
    from any source) Preservative,
    Fungicide
    Cumene 98-82-8 NA 105 3116 N/A Petroleum derivative
    Cyclohexane 110-82-7 25901 2087 Solvent Petroleum derivative
    Diesel fuel no. 2 68476-34-6 63514 3923 Insecticide, Petroleum derivative
    Adjuvant
    Ethyl benzene 100-41-4 NA 142 3197 N/A Petroleum derivative
    Ethylene 74-85-1 41901 270 Plant Growth Petroleum derivative
    Regulator
    Fuel oil #1 70892-10-3 63511 NA 520 N/A Petroleum derivative
    Fuel oil #2 68476-30-2 63505 NA 517 N/A Petroleum derivative
    Fuel oil #4 68476-31-3 63512 NA 521 N/A Petroleum derivative
    Fuel oil #6 68553-00-4 63513 NA 522 N/A Petroleum derivative
    Gasoline NA 945 NA 221 1899 N/A Petroleum derivative
    Heavy oil (coal) 301-350 deg. C. 90640-86-1 ##### NA 106 N/A Petroleum derivative
    (AWPI)
    Hydrotreated paraffinic solvent NA 91 NA 182 2601 Solvent Petroleum derivative
    Isobutane 75-28-5 97101 2621 Propellant Petroleum derivative
    Isoparaffin, C11-C12 NA 85 NA 163 2623 N/A Petroleum derivative
    Isoparaffin, C12-C14 NA 86 NA 164 2624 N/A Petroleum derivative
    Isoparaffinic hydrocarbons 64771-72-8 ##### 1641 N/A Petroleum derivative
    Isopentane 78-78-4 NA 165 3244 Solvent Petroleum derivative
    Jet fuel 94114-58-6 63515 NA 523 Insecticide, Petroleum derivative
    Solvent
    Kerosene 8008-20-6 63501 2071 Insecticide Petroleum derivative
    KM spray oil NA 78 NA 150 2631 N/A Petroleum derivative
    Ligroin 8032-32-4 63506 2642 Solvent Petroleum derivative
    Low molecular weight 64642-47-8 NA 173 5252 Insecticide Petroleum derivative
    paraffinic oil
    MCIAL code 401 64742-55-8 63503 2045 Insecticide, Petroleum derivative
    Adjuvant
    Mineral oil 8012-95-1 63502 401 Insecticide, Petroleum derivative
    Adjuvant
    Mineral oil, petroleum 64741-89-5 63503 3846 Herbicide, Petroleum derivative
    distillates, solvent refined light Plant Growth
    Regulator,
    Insecticide,
    Adjuvant
    Mineral oil, petroleum extract, 64724-04-7 NA 171 3847 Insecticide, Petroleum derivative
    heavy paraffinic distillate Adjuvant
    Mineral seal oil NA 930 NA 67 2687 Insecticide, Petroleum derivative
    Adjuvant
    Mineral spirits 8032-32-4 63506 2688 Insecticide, Petroleum derivative
    Solvent,
    Fungicide
    n-Hexane 110-54-3 NA 103 3227 Solvent Petroleum derivative
    Naphtha, heavy aromatic 64742-94-5 6602 1717 Insecticide, Petroleum derivative
    Solvent
    Orchex 796 oil NA 899 NA 172 5179 Insecticide, Petroleum derivative
    Adjuvant
    Paraffin wax 8002-74-2 NA 107 1214 Rodenticide Petroleum derivative
    Paraffin waxes (petroleum) 64742-51-4 NA 694 3545 N/A Petroleum derivative
    hydrotreated
    Paraffin waxes and 61788-76-9 NA 693 3721 N/A Petroleum derivative
    hydrocarbon waxes,
    chlorinated
    Pentane 109-66-0 98001 469 Solvent Petroleum derivative
    Petroleum derivative resin 64742-16-1 11401 1411 N/A Petroleum derivative
    Petroleum distillates 2227378 63503 763 Insecticide Petroleum derivative
    Petroleum distillates, aliphatic 2227378 63503 2768 Insecticide, Petroleum derivative
    Adjuvant,
    Solvent
    Petroleum distillates, aromatic 68477-31-6 6501 1814 Solvent, Petroleum derivative
    Herbicide,
    Insecticide
    Petroleum distillates, refined 64741-51-1 NA 654 2106 Insecticide Petroleum derivative
    Petroleum hydrocarbons 8012-95-1 63502 473 Insecticide, Petroleum derivative
    Solvent
    Petroleum jelly 2229873 ##### 1443 Insect Petroleum derivative
    Repellent,
    Adjuvant
    Petroleum naphthenic oils NA 990 NA 655 2107 Insecticide, Petroleum derivative
    Adjuvant
    Petroleum oil, unclassified 68815-10-1 NA 121 765 Insecticide, Petroleum derivative
    Herbicide,
    Fungicide,
    Adjuvant
    Petroleum sulfonates 61789-85-3 ##### 766 N/A Petroleum derivative
    Petroleum, unrefined 2227378 63503 1730 Insecticide, Petroleum derivative
    Adjuvant
    Polybutenes 9003-29-6 11402 1040 Rodenticide Petroleum derivative
    Polyisobutylene 9003-27-4 11403 1561 Rodenticide Petroleum derivative
    Propane 74-98-6 NA 109 2832 Propellant Petroleum derivative
    Propylene 1150-70-1 NA 800 2838 N/A Petroleum derivative
    Solvent naphtha (coal), 150-200 65996-79-4 ##### NA 106 Solvent Petroleum derivative
    deg. C.
    Solvent naphtha (petroleum), 64742-95-6 86803 3804 Solvent Petroleum derivative
    light aromatic
    Summer oil NA 1468 NA 218 NA 218 Insecticide, Petroleum derivative
    Adjuvant
    Sun superior spray oil 7N NA 769 NA 139 2902 Insecticide, Petroleum derivative
    Adjuvant
    Synthetic beeswax NA 509 NA 920 2910 N/A Petroleum derivative
    Tar NA 1312 22004 NA 176 Wood Petroleum derivative
    Preservative
    Tar acid oil NA 1041 NA 139 2914 Insecticide Petroleum derivative
    Toluene 108-88-3 80601 1281 Solvent Petroleum derivative
    Turpentine 8006-64-2 84501 605 Insecticide, Petroleum derivative
    Adjuvant
    White mineral oil 8042-47-5 63510 NA 519 Insecticide, Petroleum derivative
    Adjuvant
    Winter oil NA 1472 NA 219 NA 218 Adjuvant Petroleum derivative
    Xylene 1330-20-7 86802 622 Solvent, Petroleum derivative
    Microbiocide
    Xylene range aromatic solvent 68920-06-9 NA 102 862 Solvent, Petroleum derivative
    Insecticide
    3-(3-hydroxypropyl)-heptamethyl NA 90 NA 178 2610 Adjuvant Silicone
    trisiloxane, ethoxylated,
    acetate
    Compounded silicone NA 703 NA 129 2124 Adjuvant Silicone
    Dimethyl poly sloxane 63148-62-9 NA 104 1861 Insecticide, Silicone
    Adjuvant
    Dimethyl silicone fluid NA 696 NA 128 2028 Adjuvant Silicone
    emulsion
    Dow Corning antifoam Y-30 NA 146 NA 280 2539 Adjuvant Silicone
    emulsion
    Dow Corning DB-110A- NA 577 NA 104 2540 Adjuvant Silicone
    antifoam emulsion
    Heptamethyltrisiloxane 67674-67-3 NA 153 4009 Adjuvant Silicone
    ethoxylated (8 EO)
    Methyl silicone resins 9016-00-6 NA 77 3689 Adjuvant Silicone
    Methylated silica 67762-90-7 NA 173 5292 N/A Silicone
    Organo/modified polysiloxane 37281-78-0 NA 153 3997 Adjuvant Silicone
    Organosilicone, polyoxyalkylene 67762-85-0 NA 173 5231 Adjuvant Silicone
    ether copolymer
    Polyalkene oxide modified 27306-78-1 NA 146 3520 Adjuvant Silicone
    heptamethyl trisiloxane
    Polyalkyleneoxide modified NA 904 NA 172 5203 Adjuvant Silicone
    polydimethyl-siloxane
    Polyether modified NA 906 NA 172 5223 Adjuvant Silicone
    polysiloxane
    Polysiloxane NA 1337 NA 180 5718 Adjuvant Silicone
    Silicone NA 815 NA 150 3796 Adjuvant Silicone
    Silicone defoamer NA 462 NA 826 1917 Adjuvant Silicone
    Silicone mold release agent SM NA 463 NA 827 2854 N/A Silicone
    2140
    Silicone-polyether copolymer 27306-78-1 NA 151 3841 Adjuvant Silicone
    Trimethyl siloxy stearate NA 541 NA 987 2965 N/ A Silicone
    1,1,2,3-tetramethyl butylamine NA 1010 NA 948 3472 Microbiocide, Soap
    dodecyl benzene sulfonate Adjuvant,
    Fungicide,
    Insecticide
    1,3-propane diamine dodecyl NA 1021 NA 115 3369 Microbiocide, Soap
    benzene sulfonate Adjuvant,
    Fungicide,
    Insecticide
    2,2-oxybis (4-dodecyl benzene NA 1161 NA 175 1741 Microbiocide, Soap
    sulfonate) Adjuvant,
    Fungicide,
    Insecticide
    2-((2-amino ethyl) amino) 68084-55-9 NA 538 3034 Microbiocide, Soap
    ethanol dodecyl benzene Adjuvant,
    sulfonate Fungicide,
    Insecticide
    Alkanolamide surfactants NA 911 NA 174 5322 Soap/Surfactant, Soap
    Adjuvant
    Alkyl* sodium benzene 68411-30-3 ##### NA 126 Microbiocide, Soap
    sulfonate *(56% C11, 33% C12, Adjuvant,
    7% C10, 4% C13) Fungicide,
    Insecticide
    Ammonium lauryl sulfate 2235-54-3 79028 1017 Adjuvant, Soap
    Insecticide,
    Microbiocide,
    Fungicide
    Ammonium oleate 544-60-5 31703 1230 Adjuvant, Soap
    Insecticide
    Ammonium tall oil fatty acid 544-60-5 31703 995 Adjuvant, Soap
    soap Insecticide
    Benzene, 1,1′-oxybis- 119345-04-9 NA 147 3561 Microbiocide, Soap
    tetrapropylene derivatives, Adjuvant,
    sulfonated, sodium Fungicide,
    Insecticide
    Butylamine dodecyl benzene 12068-09-6 NA 469 3079 Microbiocide, Soap
    sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Coconut oil soap NA 199 NA 391 2088 Adjuvant, Soap
    Insecticide,
    Soap/Surfactant
    DEA-dodecyl benzene 26545-53-9 79015 3123 Microbiocide, Soap
    sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Diethylamine salt of coconut NA 210 NA 402 1066 Adjuvant, Soap
    fatty acid Soap/Surfactant
    Diisopropylamine dodecyl 29061-61-8 NA 327 3156 Microbiocide, Soap
    benzene sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Dimethylalmine propylamine NA 953 NA 318 3162 Microbiocide, Soap
    tridecyl benzene sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Dimethylamine dodecyl NA 954 NA 324 3161 Microbiocide, Soap
    benzene sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Disodium 2,2′-oxybis(4- 5136-51-6 79003 3175 Microbiocide, Soap
    dodecylbenzene)sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Disodium 4-dodecyl-2,4′- 7575-62-4 79002 3172 Microbiocide, Soap
    oxydibenzene sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Dodecyl alkyl sulfonate NA 284 NA 553 1599 Adjuvant Soap
    Dodecylbenzene sulfonic acid 27176-87-0 98002 941 Adjuvant, Soap
    Microbiocide,
    Insecticide
    Ethylene diamine dodecyl 12068-06-3 NA 257 3200 Microbiocide, Soap
    benzene sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Fatty acid esters NA 1358 NA 193 NA 192 Plant Growth Soap
    Regulator,
    Insecticide,
    Adjuvant
    Free fatty acids and/or amine 84776-33-0 31801 1198 Herbicide, Deer Soap
    salts Repellent,
    Fungicide,
    Insecticide
    Hydrogenated wax, neutral NA 93 NA 187 1368 Adjuvant, Soap
    wax and alkali soaps of fatty Insecticide
    acids
    Isopropylamine 26264-05-1 79030 3247 Microbiocide, Soap
    dodecylbenzene sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Lauryl sulfate salts NA 937 NA 137 2637 Adjuvant, Soap
    Insecticide,
    Microbiocide,
    Fungicide
    Linear alkyl sulfonate, NA 283 NA 552 1836 Adjuvant Soap
    potassium salt
    Magnesium lauryl sulfate 435950 79017 1718 Adjuvant, Soap
    Insecticide,
    Microbiocide,
    Fungicide
    Mannitan coconut oil ester 26545-55-0 NA 106 3680 Adjuvant, Soap
    Soap/Surfactant
    Monoethanolamine dodecyl 26545-53-9 79015 1890 Microbiocide, Soap
    benzene sulfonate Adjuvant,
    Fungicide,
    Insecticide
    N,N-dimethyl-1,3-propane NA 950 NA 305 3168 Microbiocide, Soap
    diamine dodecyl benzene Adjuvant,
    sulfonate Fungicide,
    Insecticide
    Naphthenic soap 61790-13-4 ##### 1806 Adjuvant, Soap
    Insecticide
    Oleic acid, methyl ester 112-62-9 NA 5 2266 Adjuvant Soap
    Oleic acid, potassium salt 143-18-0 79095 865 Adjuvant Soap
    Oleic and linoleic acid, mixed NA 4 NA 6 1807 Adjuvant Soap
    potassium salts
    Organic phosphate ester NA 1 NA 1 2725 Soap/Surfactant, Soap
    surfactant Adjuvant
    Para-alkyl (C9-C13) benzene 25155-30-0 79010 1739 Microbiocide, Soap
    sulfonic acid, sodium salt Adjuvant,
    Fungicide,
    Insecticide
    Phenyl 2-trimethylammonium 22232-15-1 ##### NA 125 Microbiocide, Soap
    ethanesulfonate methyl sulfate Adjuvant,
    Fungicide,
    Insecticide
    Potash fish soap 68154-69-8 79040 496 Adjuvant, Soap
    Insecticide
    Potash soap 61790-44-1 ##### 1596 Herbicide, Soap
    Insecticide,
    Adjuvant
    Potassium alkyl benzene 27177-77-1 79008 994 Microbiocide, Soap
    sulfonates Adjuvant,
    Fungicide,
    Insecticide
    Potassium dodecylbenzene 27177-77-1 79008 1027 Microbiocide, Soap
    sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Potassium laurate 10124-65-9 79021 901 Adjuvant, Soap
    Insecticide,
    Microbiocide,
    Fungicide,
    Soap/Surfactant
    Potassium laurate and myristate NA 999 NA 780 2825 Adjuvant, Soap
    soaps Insecticide,
    Microbiocide,
    Fungicide
    Potassium laurate, other related NA 1125 NA 166 90901 Adjuvant, Soap
    Insecticide,
    Microbiocide,
    Fungicide
    Potassium lauryl sulfate 4706-78-9 NA 781 3353 Adjuvant Soap
    Potassium myristate 13429-27-1 79022 902 Adjuvant Soap
    Potassium soap of coconut 10124-65-9 79021 903 Adjuvant, Soap
    fatty acid Insecticide,
    Microbiocide,
    Fungicide,
    Soap/Surfactant
    Potassium soap of tall oil fatty 10124-65-9 79021 1409 Adjuvant, Soap
    acid Insecticide,
    Fungicide,
    Microbiocide
    Potassium stearate 593-29-3 NA 784 3361 Adjuvant Soap
    Shampoo base NA 460 NA 822 3795 Adjuvant Soap
    Soap 68952-95-4 79009 772 Microbiocide, Soap
    Insecticide,
    Deer Repellent
    Sodium alkyl* benzene 26856-61-1 79087 NA 760 Microbiocide, Soap
    sulfonate *(100% C9) Adjuvant,
    Fungicide,
    Insecticide
    Sodium benzene sulfonate 515-42-4 NA 109 974 Microbiocide, Soap
    Adjuvant,
    Fungicide,
    Insecticide
    Sodium decyl benzene 1322-98-1 79088 3394 Microbiocide, Soap
    sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Sodium di (1-alkenyl) phenoxy 39354-74-0 79060 1373 Adjuvant Soap
    benzene disulfonate
    Sodium dodecylbenzene 25155-30-0 79010 774 Microbiocide, Soap
    sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Sodium laurate 629-25-4 79026 NA 732 Adjuvant, Soap
    Insecticide,
    Microbiocide,
    Fungicide
    Sodium lauryl ether diglycol NA 1471 NA 219 NA 218 Adjuvant Soap
    sulfate
    Sodium lauryl ether sulfate 9004-82-4 79054 3799 Adjuvant, Soap
    Insecticide,
    Microbiocide,
    Fungicide,
    Soap/Surfactant
    Sodium lauryl sulfate 151-21-3 79011 907 Adjuvant, Soap
    Insecticide,
    Microbiocide,
    Fungicide
    Sodium methylundecyl 27987-00-4 79053 NA 742 Microbiocide, Soap
    benzenesulfonate Adjuvant,
    Fungicide,
    Insecticide
    Sodium mono (1-alkenyl) 39354-74-0 79060 1372 Adjuvant Soap
    phenoxy benzene disulfonate
    Sodium n-decyl sulfate 142-87-0 79077 NA 754 Adjuvant Soap
    Sodium N-methyl-N-oleyl NA 1004 NA 854 3419 Adjuvant, Soap
    laurate Insecticide,
    Microbiocide,
    Fungicide
    Sodium nonanoyloxybenzene 91129-43-8 89053 5137 Microbiocide, Soap
    sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Sodium octylbenzene sulfonate 28675-11-8 79057 NA 745 Microbiocide, Soap
    Adjuvant,
    Fungicide,
    Insecticide
    Sodium tallow soap NA 473 NA 870 3802 Adjuvant, Soap
    Insecticide
    Sodium tetradecyl sulfate 1191-50-0 NA 110 3446 Adjuvant Soap
    Sodium tridecylbenzene 26248-24-8 79072 NA 752 Microbiocide, Soap
    sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Sodium triisopropyl 1323-19-9 NA 872 3448 Insecticide, Soap
    naphthalene sulfonate Fungicide,
    Microbiocide,
    Adjuvant
    Sodium triphenyl benzene NA 1006 NA 873 3449 Microbiocide, Soap
    sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Sodium xylene sulfonate 1300-72-7 79019 909 Adjuvant Soap
    Sodium-1-octane sulfonate 5324-84-5 NA 859 3886 Adjuvant Soap
    Soybean fatty acids, tert amine NA 480 NA 884 1308 Adjuvant Soap
    salt
    Strontium dodecyl benzene 12068-15-4 NA 906 3456 Microbiocide, Soap
    sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Sulfonated petroleum soap 61789-62-6 79012 NA 729 Adjuvant, Soap
    Insecticide
    Sulfuric acid, monododecyl 151-21-3 79011 2901 Adjuvant, Soap
    ester sodium salt Insecticide,
    Microbiocide,
    Fungicide
    Surfactant blend NA 1515 NA 223 NA 222 Soap/Surfactant, Soap
    Adjuvant
    Surfactant mixture NA 1516 NA 223 NA 223 Soap/Surfactant, Soap
    Adjuvant
    Tallow soap NA 607 NA 110 1499 Adjuvant, Soap
    Insecticide
    Triethanolamine 27323-41-7 79020 984 Microbiocide, Soap
    dodecylbenzene sulfonate Adjuvant,
    Fungicide,
    Insecticide
    Zinc dodecyl benzene sulfonate 12068-16-5 NA 112 3508 Microbiocide, Soap, Inorganic-Zinc
    Adjuvant,
    Fungicide,
    Insecticide
    Cane syrup NA 228 NA 441 3598 N/A Carbohydrate
    Complex carbohydrate polymer NA 834 NA 154 4027 Adjuvant Carbohydrate
    derivative
    Corn syrup NA 580 NA 105 3628 Bait Carbohydrate
    Cornstarch NA 800 NA 148 3627 N/A Carbohydrate
    Dextrose 50-99-7 NA 360 3129 N/A Carbohydrate
    Fructose 7660-25-5 NA 177 5742 N/A Carbohydrate
    Honey NA 734 NA 134 2595 N/A Carbohydrate
    Invert sugar 8013-17-0 NA 171 3672 Bait Carbohydrate
    Invert syrup NA 941 NA 172 3673 Bait Carbohydrate
    Lactose 63-42-3 NA 141 1400 N/A Carbohydrate
    Malt extract 8002-48-0 NA 134 2659 N/A Carbohydrate
    Molasses NA
    40 NA 69 744 Bait Carbohydrate
    Polysaccharide polymer NA 702 NA 129 2112 Adjuvant Carbohydrate
    Sorbitol 50-70-4 NA 214 1629 N/A Carbohydrate
    Starch 9005-84-9 NA 898 1821 N/A Carbohydrate
    Starch-G-poly (acrylamide-co- NA 494 NA 899 2888 N/A Carbohydrate
    sodium acrylate)
    Sugar 57-50-1 23 708 Bait Carbohydrate
    Sweet n′ neat 45 spray dried NA 634 NA 116 3565 N/A Carbohydrate
    honey powder
    Validamycin 37248-47-8 NA 190 NA 189 Fungicide Carbohydrate
    alpha-Cellulose NA 1537 NA 225 NA 224 Insecticide Cellulose derivative
    Carbo methoxy ether cellulose, 9004-32-4 ##### 2446 Insecticide Cellulose derivative
    sodium salt
    Cellulose 9004-34-6 NA 432 3100 N/A Cellulose derivative
    Cellulose ethyl hydroxy ethyl 9004-58-4 NA 113 3101 N/A Cellulose derivative
    ether
    Ethyl cellulose 9004-57-3 NA 264 3652 N/A Cellulose derivative
    Hydroxyethyl cellulose 9004-62-0 46201 1511 N/A Cellulose derivative
    Hydroxypropyl methyl 9004-65-3 NA 179 1969 N/A Cellulose derivative
    cellulose
    Methyl cellulose 9004-67-5 NA 85 1205 N/A Cellulose derivative
    Microcrystalline cellulose 9004-34-6 NA 63 2686 N/A Cellulose derivative
    Nitrocellulose 9004-70-0 99601 NA 867 N/A Cellulose derivative
    (2- 41289-08-1 ##### NA 101 N/A Unclassified
    chloroethyl)methylbis(phenylmethoxy)
    silane
    1% verde green solution NA 553 NA 100 2982 Dye Unclassified
    1,2-dimethyl hydrazine 540-73-0 NA 142 3165 N/A Unclassified
    1,2-epoxy butane 106-88-7 NA 142 3190 N/A Unclassified
    1,3-butadiene 106-99-0 NA 471 2431 N/A Unclassified
    1-((4-methyl-2-nitrophenyl) NA 43 NA 80 2682 N/A Unclassified
    azo) naphthalenol
    1-methyl pyrrolidine 120-94-5 NA 75 3287 N/A Unclassified
    1-Pentanethiol 110-66-7 ##### NA 872 N/A Unclassified
    2,2′-octadecyl imino diethanol 10213-78-2 NA 20 3306 N/A Unclassified
    2,2′-oxybis (4,4,6-trimethyl- 14697-50-8 12402 792 Microbiocide Unclassified
    1,3,2-dioxaborinane)
    2-butanone oxime 96-29-7 NA 474 3071 N/A Unclassified
    2-chloropyridine-N-oxide NA 219 NA 417 2466 N/A Unclassified
    2-ethyl hexanoic acid 149-57-5 ##### 3228 N/A Unclassified
    2-ethyl hexyl acrylate 103-11-7 NA 252 2115 N/A Unclassified
    2-heptanone 110-43-0 NA 206 3223 N/A Unclassified
    2-hydroxy-4-n-octyl NA 572 NA 103 2608 N/A Unclassified
    benzophenone
    2-mercapto pyridine 2637-34-5 NA 94 2671 N/A Unclassified
    2-nitro-1-butyl phosphate 57249-19-1 56902 2033 N/A Unclassified
    2-Nitropropane 79-46-9 ##### 3301 Impurity Unclassified
    3′,6′-Dihydro-2′,4′,5′,7′- 15905-32-5 ##### NA 981 Dye Unclassified
    tetraiodospiro(isobenzofuran-
    1(3H),9′-(9H)xanthen)-3-one
    4-hydroxydiphenylamine 122-37-2 NA 217 NA 217 Breakdown Unclassified
    product
    5-methyl-2-hexanone 110-12-3 NA 81 3230 N/A Unclassified
    Acetaldehyde 75-07-0 ##### 3012 N/A Unclassified
    Acetic anhydride 108-24-7 44007 3014 N/A Unclassified
    Acetone 67-64-1 44101 747 Solvent Unclassified
    Acetonitrile 75-05-8 NA 699 3015 Solvent Unclassified
    Acetophenone 98-86-2 ##### 2074 N/A Unclassified
    Acid blue 182 NA 599 NA 108 2353 Dye Unclassified
    Acid blue 7 NA 385 NA 702 2352 Dye Unclassified
    Acid blue 9, diammonium salt 2650-18-2 ##### 2154 Herbicide, Dye Unclassified
    Acid blue 9, disodium salt 3844-45-9 ##### 3562 Herbicide, Dye Unclassified
    Acid yellow 23 1934-21-0 ##### 2155 Herbicide, Dye Unclassified
    Acridinic bases NA 1356 NA 193 NA 192 Repellent Unclassified
    Acrylic acid 79-10-7 NA 129 2118 N/A Unclassified
    AD-67 NA 1378 NA 195 NA 194 Herbicide Unclassified
    Safener
    Adjuvants NA 1484 NA 221 NA 220 Adjuvant Unclassified
    Agent 1059-106 NA 388 NA 708 2357 N/A Unclassified
    Agent 1059-108 NA 600 NA 108 2358 N/A Unclassified
    Agent 1315-33A NA 389 NA 709 3881 N/A Unclassified
    Agent 1315-33N NA 390 NA 710 3879 N/A Unclassified
    Agent 1594-9 NA 654 NA 120 3880 N/A Unclassified
    Agent 551-85 NA 387 NA 707 2356 N/A Unclassified
    Agent W-218 NA 391 NA 711 2359 N/A Unclassified
    Aldehyde C10 112-31-2 ##### NA 107 N/A Unclassified
    Aldehyde C11 112-44-7 ##### NA 107 N/A Unclassified
    Aldehyde C12 112-54-9 ##### NA 107 N/A Unclassified
    Aldehyde C6 66-25-1 ##### NA 107 N/A Unclassified
    Aldehyde C8 124-13-0 ##### NA 107 N/A Unclassified
    Aldimorph NA 1340 NA 188 NA 187 Fungicide Unclassified
    Aliphatic amines NA 713 NA 130 2362 N/A Unclassified
    Alkanol XC NA 828 NA 152 3931 Adjuvant Unclassified
    Alkatronic PGP-33-4 NA 395 NA 717 2363 N/A Unclassified
    Alkyl (C9H12) benzenes NA 310 NA 589 2371 Solvent Unclassified
    Amine 220 21652-27-7 NA 141 3033 N/A Unclassified
    Amines, aliphatic NA 277 NA 543 1747 N/A Unclassified
    Amino acids NA 1359 NA 193 NA 192 Plant Growth Unclassified
    Regulator
    Ammonium propionate NA 1061 NA 158 5015 Microbiocide, Unclassified
    Preservative
    Amsco-solv NA 271 NA 526 2386 Solvent Unclassified
    Amygdalinic acid diethyl NA 1448 NA 215 NA 214 Insect Unclassified
    amide Repellent
    Amyl acetate 628-63-7 169 1889 N/A Unclassified
    Aniline 62-53-3 ##### 3056 N/A Unclassified
    Anionic wax emulsion 61789-97-7 NA 515 3818 N/A Unclassified
    Anionic wax emulsion NA 892 NA 171 3848 N/A Unclassified
    Aquashade 92170-50-8 ##### NA 909 Herbicide, Dye Unclassified
    Armul 1426 NA 267 NA 522 3878 N/A Unclassified
    Armul 1426 HF NA 822 NA 151 3877 N/A Unclassified
    Armul 1427 NA 268 NA 523 3883 N/A Unclassified
    Armul 1427 HF NA 589 NA 106 3876 N/A Unclassified
    Armul 214/215 NA 265 NA 520 2391 N/A Unclassified
    Armul 22 NA 263 NA 518 2389 N/A Unclassified
    Armul 33 NA 587 NA 106 2390 N/A Unclassified
    Armul 358 NA 266 NA 521 2392 N/A Unclassified
    Armul 646 NA 588 NA 106 2393 N/A Unclassified
    Armul
    88 NA 264 NA 519 3908 N/A Unclassified
    Artificial peanut butter flavor NA 717 NA 131 2397 N/A Unclassified
    wl-5344
    Astrazon yellow 4g200 NA 258 NA 511 2399 Dye Unclassified
    Atlox 1045A 61723-83-9 NA 152 3911 N/A Unclassified
    Atplus 300F NA 255 NA 507 3916 N/A Unclassified
    b-Bromo-b-nitrostyrene 7166-19-0 NA 221 NA 221 Microbiocide Unclassified
    Barochem B464 NA 247 NA 499 2413 N/A Unclassified
    Basic violet 1 8004-87-3 39503 3584 Dye Unclassified
    BCP NA 237 NA 465 64 N/A Unclassified
    Be-4526 phthalo blue lake r-c NA 244 NA 488 3518 Dye Unclassified
    Benfuresate 68505-69-1 NA 187 NA 187 Herbicide Unclassified
    Bensultap 17606-31-4 NA 185 NA 185 Insecticide Unclassified
    Benzene sulfonyl chloride 98-09-9 NA 489 2415 N/A Unclassified
    Benzfendizone 158755-95-4 NA 230 NA 230 Herbicide Unclassified
    Benzobicyclon 156963-66-5 NA 230 NA 230 Herbicide Unclassified
    Benzofenap 82692-44-2 NA 211 NA 211 Herbicide Unclassified
    Benzophenone-2 131-55-5 NA 492 3063 N/A Unclassified
    Benzophenone-3 119-61-9 315 2417 N/A Unclassified
    Benzyl chloride 100-44-7 NA 486 2419 N/A Unclassified
    Berol 927 NA 894 NA 171 3874 N/A Unclassified
    Berol 968 NA 893 NA 171 3873 N/A Unclassified
    Bethoxazin 163269-30-5 NA 230 NA 230 Herbicide Unclassified
    BHA 25013-16-5 NA 484 2420 N/A Unclassified
    Bicyclic and methene resins NA 242 NA 485 3516 N/A Unclassified
    Bioban p-1487 37304-88-4 ##### 1742 Microbiocide Unclassified
    Biphenyl 92-52-4 17002 227 Microbiocide, Unclassified
    Fungicide
    Bisphenol A 80-05-7 NA 482 3070 N/A Unclassified
    Bisphenol F 205672 NA 216 NA 215 N/A Unclassified
    Bispyribac 125401-75-4 NA 203 NA 203 Herbicide Unclassified
    Bisthiosemi 39603-48-0 NA 206 NA 206 Rodenticide Unclassified
    Block polymer of NA 850 NA 158 5011 N/A Unclassified
    carbonyldiamide
    polyoxyalkylated glycol adduct
    Brandol NA 1379 NA 195 NA 194 Fungicide Unclassified
    Bromoacetic acid 79-08-3 8702 NA 102 N/A Unclassified
    Burgundy mixture NA 1380 NA 195 NA 194 Fungicide Unclassified
    Busan 1009 NA 1564 NA 227 NA 227 Fungicide Unclassified
    Butadiene-acrylonitrile 9003-18-3 NA 472 2432 N/A Unclassified
    copolymer
    Butane 106-97-8 NA 473 1562 N/A Unclassified
    Buthiobate 51308-54-4 NA 206 NA 206 Fungicide Unclassified
    Butyl mercaptan 109-79-5 ##### 5087 Deer Repellent, Unclassified
    Bear Repellent
    C-PA-1224 black NA 191 NA 379 2483 N/A Unclassified
    Calcium propionate 4075-81-4 77701 2441 Preservative Unclassified
    Cambendichlor 56141-00-5 NA 230 NA 230 Herbicide Unclassified
    Capric acid 334-48-5 ##### 2315 Microbiocide Unclassified
    Caprylic acid 124-07-2 ##### 2316 Microbiocide Unclassified
    Caramel color NA 720 NA 131 2444 Dye Unclassified
    Carfentrazone 128621-72-7 NA 210 NA 210 Herbicide Unclassified
    Carfentrazone-ethyl 128639-02-1 ##### 5130 Herbicide Unclassified
    Carpropamid 104030-54-8 NA 203 NA 203 Fungicide Unclassified
    Cartap 15263-53-3 NA 181 NA 181 Insecticide Unclassified
    Cartap hydrochloride 22042-59-7 NA 182 NA 181 Insecticide Unclassified
    (unspecified hydrochloride)
    Cartap monohydrochloride 15263-52-2 NA 182 NA 181 Insecticide Unclassified
    Cetiol HE 66105-29-1 ##### NA 871 Insecticide Unclassified
    CGA-154281 NA 721 NA 132 2451 N/A Unclassified
    Chartersol-1 NA 221 NA 428 2453 Solvent Unclassified
    Chem-o-thane D-3860/D-3861 NA 223 NA 430 2454 N/A Unclassified
    Chicago sludge 68188-15-8 NA 147 3605 N/A Unclassified
    Chloracetic acid 79-11-8 ##### 3102 N/A Unclassified
    Chloral-bis-acylal NA 1344 NA 191 NA 191 Plant Growth Unclassified
    Regulator
    Chloral-semi-acetal NA 1345 NA 191 NA 191 Herbicide Unclassified
    Chloretazate NA 1403 NA 197 NA 196 Plant Growth Unclassified
    Regulator
    Chlorfenprop 59404-06-7 NA 181 NA 180 Herbicide Unclassified
    Chlorfenprop-methyl 14437-17-3 ##### NA 156 Herbicide Unclassified
    Chlorinated rubber 2594016 NA 427 3606 N/A Unclassified
    Chlormethiuron 28217-97-2 NA 206 NA 206 Insecticide Unclassified
    Chlorobenzene 108-90-7 56504 2460 N/A Unclassified
    Choline chloride 67-48-1 NA 191 NA 190 Rodenticide Unclassified
    Cinidon-ethyl 142891-20-1 NA 216 NA 215 Herbicide Unclassified
    Citowett NA 218 NA 412 2471 Soap/Surfactant Unclassified
    Cloquintocet 88349-88-6 NA 219 NA 218 Herbicide Unclassified
    Safener
    Cloquintocet mexyl 99607-70-2 NA 191 NA 190 Herbicide Unclassified
    Safener
    Cloxyfonac 32791-87-0 NA 204 NA 203 Plant Growth Unclassified
    Regulator
    Colgate crystal white hand NA 202 NA 393 2476 N/A Unclassified
    dishwashing liquid
    Collagen NA 203 NA 394 1805 N/A Unclassified
    Colloid 643 NA 582 NA 105 2477 N/A Unclassified
    Colloid 840 NA 791 NA 146 3527 N/A Unclassified
    Cookies NA 641 NA 117 3621 Bait Unclassified
    Credazine 14491-59-9 NA 207 NA 206 Herbicide Unclassified
    Cubiet NA 1367 NA 193 NA 193 Fungicide, Unclassified
    Pruning Aid
    Cyclohexanone 108-94-1 25902 177 Solvent Unclassified
    Cyclopentadiene polymer NA 1450 NA 215 NA 214 Insecticide Unclassified
    Cymiazol hydrochloride 61676-87-7 NA 215 NA 214 Insecticide Unclassified
    Cymoxanil 57966-95-7 ##### 4002 Fungicide Unclassified
    Cyometrinil 63278-33-1 NA 207 NA 206 Herbicide Unclassified
    Safener
    Cysteine 52-90-4 NA 190 NA 190 Plant Growth Unclassified
    Regulator
    D & C red no. 28 18472-87-2 ##### 3515 Dye Unclassified
    D & C red no. 37 1632455 NA 117 3634 Dye Unclassified
    D & C yellow 10 lake 68814-04-0 NA 365 2487 Dye Unclassified
    D & C yellow no. 8 NA 829 NA 152 3991 Dye Unclassified
    D-425 NA 184 NA 367 2489 N/A Unclassified
    D-79 solvent NA 183 NA 366 2488 Solvent Unclassified
    Daxad 23 NA 185 NA 368 2491 N/A Unclassified
    Day-glo saturn yellow AX-17-N NA 186 NA 369 2492 Dye Unclassified
    DE-570 NA 1459 NA 216 NA 216 N/A Unclassified
    Delvet 65 NA 177 NA 357 2494 N/A Unclassified
    Desoto urethane resin NA 179 NA 359 2497 N/A Unclassified
    Device (swimming pool NA 1503 NA 222 NA 222 Algaecide, Unclassified
    algaecide, bacteriacide, Microbiocide,
    molluscicide) no guarantee Molluscicide
    required
    Device, no guarantee required NA 1502 NA 222 NA 221 N/A Unclassified
    Di-1-p-menthene NA 1381 NA 195 NA 194 Plant Growth Unclassified
    Regulator
    Diafenthiuron 80060-09-9 NA 186 NA 185 Insecticide Unclassified
    Dichloro acetic acid 79-43-6 NA 105 3133 N/A Unclassified
    Dichlorovinyl acid NA 174 NA 347 2502 Breakdown Unclassified
    product
    Diclobutrazol 75736-33-3 NA 186 NA 185 Fungicide Unclassified
    Diclomezine 62865-36-5 NA 204 NA 204 Fungicide Unclassified
    Dicyclanil 112636-83-6 NA 211 NA 211 Insect Growth Unclassified
    Regulator
    Dicyclopentadiene 77-73-6 NA 186 NA 185 Plant Growth Unclassified
    Regulator, Dog
    and Cat
    Repellent
    Dicyclopentadiene linseed oil 68213-53-6 31612 NA 291 N/A Unclassified
    copolymer
    Diethyl phosphate 598-02-7 NA 180 NA 179 Breakdown Unclassified
    product
    Diethyl sulfide 352-93-2 ##### 5088 Bear Repellent Unclassified
    Diethyldithio phosphate 298-06-6 NA 180 NA 179 Breakdown Unclassified
    product
    Diethylthio phosphate 5871-17-0 NA 180 NA 179 Breakdown Unclassified
    product
    Diisoamyl ketone 2050-99-9 NA 325 3155 Solvent Unclassified
    Diisobutyl ketone 108-83-8 44107 1946 Solvent Unclassified
    Dikegulac 18467-77-1 NA 181 NA 180 Herbicide Unclassified
    Dikegulac sodium 52508-35-7 ##### 2004 Plant Growth Unclassified
    Regulator
    Dimer acid 6144-28-1 NA 330 3158 N/A Unclassified
    Dimethyl phosphate 813-78-5 NA 180 NA 179 Breakdown Unclassified
    product
    Dimethyl sulfoxide 67-68-5 177 3169 Solvent Unclassified
    Dimethyldithio phosphate 756-80-9 NA 180 NA 180 Breakdown Unclassified
    product
    Dimethylthio phosphate NA 1339 NA 180 NA 179 Breakdown Unclassified
    product
    Dioxane 123-91-1 NA 300 2529 Solvent, Unclassified
    Impurity
    Diphenyl methane 101-81-5 NA 301 3171 N/A Unclassified
    Diphenylamine 122-39-4 38501 228 Fungicide, Unclassified
    Plant Growth
    Regulator,
    Insecticide
    Dipropyl isocinchomerate 3737-22-2 NA 204 NA 204 Insect Unclassified
    Repellent
    Dipropyl isocinchomeronate 136-45-8 47201 681 Insect Unclassified
    Repellent
    Dog or cat collars NA 155 NA 291 3645 N/A Unclassified
    Dow Corning FG-10 NA 147 NA 281 2541 N/A Unclassified
    Dowanol desg solvent NA 725 NA 133 2538 Solvent Unclassified
    Drewplus L-768 NA 148 NA 283 2542 N/A Unclassified
    Dyestuffs NA 689 NA 127 1913 Dye Unclassified
    Emcol AL69-49 NA 726 NA 133 2544 N/A Unclassified
    Emphos CS-121 NA 727 NA 133 2545 Soap/Surfactant Unclassified
    Emulgator NA 143 NA 277 2546 N/A Unclassified
    Emulsogen CP 136 NA 576 NA 104 2547 Adjuvant Unclassified
    Emulsogen NP 11-300 NA 144 NA 278 2548 Adjuvant Unclassified
    Endothall 145-73-3 38901 5813 Herbicide, Unclassified
    Defoliant
    Endothall, di (N,N- NA 949 NA 271 1355 Herbicide, Unclassified
    diethylalkylamine) salt Defoliant
    Endothall, di (N,N- 66330-88-9 38905 1904 Herbicide, Unclassified
    dimethylalkylamine) salt Defoliant
    Endothall, di(N,N- 2536-26-7 38902 NA 323 Herbicide, Unclassified
    dimethyltridecylamine) salt Defoliant
    Endothall, diammonium salt 17439-94-0 38908 NA 326 Herbicide, Unclassified
    Defoliant
    Endothall, dipotassium salt 2164-07-0 38904 1356 Herbicide, Unclassified
    Defoliant
    Endothall, disodium salt 129-67-9 38903 260 Herbicide, Unclassified
    Defoliant
    Endothall, mono (N,N-diethyl NA 926 NA 4 1354 Herbicide, Unclassified
    alkylamine) salt Defoliant
    Endothall, mono [N,N- NA 929 NA 61 2056 Herbicide, Unclassified
    dimethyl alkylamine] salt Defoliant
    Endothall, mono(N,N- 2536-27-8 38906 NA 325 Herbicide, Unclassified
    dimethyltridecylamine) salt Defoliant
    Endothall, N,N- NA 1282 38907 NA 174 Herbicide, Unclassified
    dimethylcocamine salt (1:2) Algaecide
    Epoxidized linseed oil 2232670 NA 272 2550 Insecticide, Unclassified
    Adjuvant
    Epoxy resins NA 139 NA 269 3650 N/A Unclassified
    Erythrosine B 16423-68-0 ##### 2224 Dye, Unclassified
    Insecticide
    Escorez 1102 9048-47-9 NA 146 3546 N/A Unclassified
    Espesol I NA 140 NA 270 2552 Solvent Unclassified
    Etacelasil 37894-46-5 NA 188 NA 187 Defoliant, Plant Unclassified
    Growth
    Regulator
    Ethanethiol 75-08-1 NA 187 NA 186 Rodenticide Unclassified
    Ethomeen NA 136 NA 265 2553 N/A Unclassified
    Ethyl acrylate 140-88-5 NA 259 2117 N/A Unclassified
    Ethyl formate 109-94-4 43102 278 Fumigant, Unclassified
    Insecticide
    Ethyl methacrylate 97-63-2 NA 248 3203 N/A Unclassified
    Ethylene-acrylic acid 9010-77-9 NA 253 3653 Adjuvant Unclassified
    copolymer
    Ethylene-acrylic terpolymer NA 133 NA 254 1950 Adjuvant Unclassified
    Ethylhexanoate 123-66-0 NA 190 NA 190 Fungicide, Unclassified
    Microbiocide
    Extender NA 1377 NA 195 NA 194 Synergist Unclassified
    Fatty alcohols NA 1364 NA 193 NA 192 Plant Growth Unclassified
    Regulator,
    Adjuvant
    FD&C blue no. 1 aluminum 53026-57-6 NA 242 3000 Dye Unclassified
    lake
    FD&C green no. 3 NA 127 NA 243 2566 Dye Unclassified
    FD&C red no. 40 NA 947 ##### 2567 Dye, Impurity Unclassified
    Feed supplements NA 128 NA 244 3655 N/A Unclassified
    Fenchlorazole 103112-35-2 NA 181 NA 181 Herbicide Unclassified
    Safener
    Fenchlorim 3740-92-9 NA 182 NA 181 Herbicide Unclassified
    Safener
    Fenitropan 65934-95-4 NA 207 NA 207 Fungicide Unclassified
    Fenpiclonil 74738-17-3 NA 188 NA 187 Fungicide Unclassified
    Fenpropidin 67306-00-7 NA 184 NA 183 Fungicide Unclassified
    Fenpropimorph 67306-03-0 ##### NA 988 Fungicide Unclassified
    Fenpropimorph 67564-91-4 NA 201 NA 200 Fungicide Unclassified
    Fenthiosulf NA 1406 NA 198 NA 197 Insecticide Unclassified
    Fertilizer, general NA 729 NA 133 2569 N/A Unclassified
    Filter paper e-d-601-25 NA 122 NA 235 3525 N/A Unclassified
    Flomo 1212 NA 124 NA 239 2572 Soap/Surfactant Unclassified
    Flomo 4NP NA 616 NA 112 2573 Soap/Surfactant Unclassified
    Florasulam NA 1447 NA 214 NA 214 Herbicide Unclassified
    Flubenzimine (unstated 37893-02-0 NA 188 NA 187 Insecticide Unclassified
    stereochemistry)
    Flumequine 42835-25-6 NA 188 NA 187 Microbiocide Unclassified
    Flumiclorac 87547-04-4 NA 232 NA 232 Herbicide Unclassified
    Flumipropyn 84478-52-4 NA 229 NA 229 Herbicide Unclassified
    Flupropanate 756-09-2 NA 204 NA 204 Herbicide Unclassified
    Flupropanate, sodium salt 22898-01-7 NA 211 NA 211 Herbicide Unclassified
    Flurazole 72850-64-7 NA 187 NA 186 Herbicide Unclassified
    Safener
    Flurtamone 96525-23-4 NA 217 NA 216 Herbicide Unclassified
    Fluthiacet 149253-65-6 NA 205 NA 204 Herbicide Unclassified
    Fluxofenim 88485-37-4 NA 202 NA 201 Herbicide Unclassified
    Safener
    Formaldehyde 50-00-0 43001 295 Microbiocide, Unclassified
    Fungicide
    Fosetyl-A1 39148-24-8 ##### 2210 Fungicide Unclassified
    Fragrance 1256 H NA 115 NA 227 2575 Fragrance Unclassified
    Fragrance for mosquito 51843 NA 140 3007 Fragrance Unclassified
    repellent p-7510
    Fragrance N-5716 NA 116 NA 228 3852 Fragrance Unclassified
    Fragrance orange 418228 NA 117 NA 229 3889 Fragrance Unclassified
    Fragrance PNLF 6986 NA 633 NA 116 3563 Fragrance Unclassified
    Fragrance RS-2661 NA 824 NA 151 3891 Fragrance Unclassified
    Frambinone 5471-51-2 NA 212 NA 212 Fragrance Unclassified
    Fumaric acid 110-17-8 51201 297 N/A Unclassified
    Fumaric and crotonic acids, NA 118 NA 230 1711 N/A Unclassified
    esters of
    Fumigants NA 1492 NA 221 NA 221 Fumigant Unclassified
    Furaneol 15% p.g. NA 119 NA 231 2576 N/A Unclassified
    Furfural 98-01-1 43301 1522 N/A Unclassified
    Gentian 97676-22-7 ##### NA 108 Dye Unclassified
    Gentian violet 548-62-9 39502 1270 Microbiocide, Unclassified
    Dye
    Gentian violet 548-62-9 98401 NA 173 Microbiocide, Unclassified
    Dye
    Givaudan muquet PA-6664 NA 575 NA 104 2580 N/A Unclassified
    Glidden no. 3200 white latex NA 113 NA 224 2581 N/A Unclassified
    Glue NA 643 NA 118 3661 N/A Unclassified
    Glufosinate 51276-47-2 NA 203 NA 202 Herbicide Unclassified
    Glufosinate-ammonium 77182-82-2 ##### 3946 Herbicide Unclassified
    Grease (bands, fruit frees) NA 1350 NA 192 NA 191 Insecticide Unclassified
    Green M liquid dye NA 106 NA 211 3840 Dye Unclassified
    Heptopargil 73886-28-9 NA 208 NA 207 Plant Growth Unclassified
    Regulator
    Heptyl butyrate 5870-93-9 NA 207 3668 N/A Unclassified
    Hi-sol 15 NA 97 NA 192 2594 Solvent Unclassified
    Hostaphat MDAR-N-040 NA 98 NA 193 2596 N/A Unclassified
    Hostapon T powder highly 97-80-3 NA 171 3942 N/A Unclassified
    concentrated
    Hydrazine 302-01-2 NA 195 2598 Impurity, Unclassified
    Breakdown
    product
    Hydrolysed linseed fatty acid NA 1436 NA 212 NA 212 N/A Unclassified
    Hydroxyl amine sulfate 10039-54-0 NA 181 3235 N/A Unclassified
    Hydroxyphenyl-salicylamide NA 1396 NA 197 NA 196 Fungicide Unclassified
    Inabenfide 82211-24-3 NA 205 NA 204 Plant Growth Unclassified
    Regulator
    Indanofan 133220-30-1 NA 232 NA 232 Herbicide Unclassified
    Indigo carmine 860-22-0 NA 146 3530 Dye Unclassified
    Inert (VOC reevaluation) NA 877 NA 169 3973 N/A Unclassified
    Inert ingredients NA 872 NA 160 0 N/A Unclassified
    Instex 10100 color concentrate NA 88 NA 170 2615 Dye Unclassified
    (black)
    Irganox 1010 6683-19-8 NA 173 3623 N/A Unclassified
    Irganox 1010 6683-19-8 NA 170 3523 N/A Unclassified
    Irganox 1076 2082-79-3 NA 174 2617 N/A Unclassified
    Iso-amyl mercaptan 541-31-1 NA 213 NA 212 N/A Unclassified
    Isobutyl acetate 110-19-0 NA 143 3241 N/A Unclassified
    Isobutyric acid 79-31-2 ##### 2110 Preservative Unclassified
    Isooctyl phosphate 12645-53-3 NA 162 3258 Soap/Surfactant, Unclassified
    Adjuvant
    Isopropanolamine nitrite NA 87 NA 166 3245 N/A Unclassified
    Isopropylamine 75-31-0 NA 157 3246 N/A Unclassified
    Isoprothiolane 50512-35-1 NA 189 NA 188 Fungicide Unclassified
    Isoval NA 1385 NA 195 NA 195 Rodenticide Unclassified
    Isoxapyrifop 87757-18-4 NA 208 NA 208 Herbicide Unclassified
    Ivory snow NA 75 NA 146 3674 N/A Unclassified
    K 1A112 NA 77 NA 148 2628 N/A Unclassified
    Kelsol 5134 68309-52-4 NA 149 3526 Solvent Unclassified
    Ketoconazole 65277-42-1 NA 216 NA 215 Fungicide Unclassified
    Korax 2425-66-3 11302 351 N/A Unclassified
    Krynac 1122 NA 79 NA 151 2632 N/A Unclassified
    Latex paint NA 74 NA 144 2634 N/A Unclassified
    Leonil DB powder NA 71 NA 139 2639 N/A Unclassified
    Lignoflex NA 68 NA 131 3265 N/A Unclassified
    Limonia 19-11189 NA 69 NA 132 2643 N/A Unclassified
    Linseed-soya alkyd resin NA 62 NA 117 2646 N/A Unclassified
    Lithium 29457-72-5 75004 5678 Insecticide, Unclassified
    (perfluorooctane)sulfonate Adjuvant
    Long oil alkyd 5070 NA 64 NA 120 2648 Insecticide Unclassified
    Lubrizol 544 NA 65 NA 121 2649 Solvent, Unclassified
    Adjuvant
    Luna yellow NB-1 1270 NA 66 NA 122 2651 Dye Unclassified
    Luviset cap 25035-26-1 NA 123 3867 N/A Unclassified
    Macroplast UK 8202/UK 5400 NA 57 NA 108 2652 N/A Unclassified
    Macroplast VAX-11688/UK NA 58 NA 109 2653 N/A Unclassified
    5400
    Malachite green 569-64-2 39504 366 Dye Unclassified
    Maleic anhydride 108-31-6 NA 102 3272 N/A Unclassified
    Maleic anhydride, polymer 37199-81-8 NA 103 3271 N/A Unclassified
    with 2,4,4-trimethyl pentane,
    sodium salt
    Maleic hydrazide 123-33-1 51501 368 Plant Growth Unclassified
    Regulator
    Maleic hydrazide 10071-13-3 NA 210 NA 209 Plant Growth Unclassified
    Regulator
    Maleic hydrazide, choline salt 71203-19-5 51504 NA 422 Plant Growth Unclassified
    Regulator
    Maleic hydrazide, 5716-15-4 51502 778 Plant Growth Unclassified
    diethanolamine salt Regulator
    Maleic hydrazide, potassium 28382-15-2 51503 2130 Plant Growth Unclassified
    Regulator,
    Herbicide
    Malic acid 6915-15-7 51101 1364 Microbiocide Unclassified
    Mark 1500 NA 49 NA 96 2663 N/A Unclassified
    Mark 1600 NA 50 NA 97 2664 N/A Unclassified
    Mark 1601 NA 51 NA 98 2665 N/A Unclassified
    Mark 1603 NA 740 NA 135 2666 N/A Unclassified
    Mark 1607 NA 569 NA 103 2667 N/A Unclassified
    Mark 495 NA 56 NA 107 2660 N/A Unclassified
    Mark 565A NA 48 NA 95 2661 N/A Unclassified
    Mark 706 NA 739 NA 135 2662 N/A Unclassified
    Marter white 400 NA 52 NA 99 2668 N/A Unclassified
    Medicated block NA 47 NA 92 3684 N/A Unclassified
    Mefenpyr 135591-00-3 NA 182 NA 181 Herbicide Unclassified
    Safener
    Mefenpyr-diethyl 135590-91-9 R47618 NA 177 Herbicide Unclassified
    Safener
    Menhaden oil 8002-50-4 NA 93 3686 N/A Unclassified
    Menthol 1490-04-6 51601 1074 Dog and Cat Unclassified
    Repellent
    Methoxy-2,4-dihydroxy NA 46 NA 89 3281 N/A Unclassified
    pentene
    Methoxyphenone 41295-28-7 NA 209 NA 208 Herbicide Unclassified
    Methyl esters of cottonseed oil 61788-60-1 NA 148 3687 Adjuvant Unclassified
    Methyl ethyl ketone 78-93-3 44103 2680 Solvent Unclassified
    Methyl formate 107-31-3 53701 391 Fumigant Unclassified
    Methyl hydrogenated rosinate 8050-15-5 NA 82 3688 N/A Unclassified
    Methyl isocyanate 624-83-9 NA 180 NA 180 Breakdown Unclassified
    product
    Methyl isothiocyanate 556-61-6 68103 392 Fumigant, Unclassified
    Insecticide,
    Herbicide,
    Nematicide,
    Breakdown
    product
    Methyl methacrylate 80-62-6 NA 78 2151 N/A Unclassified
    Methylene blue 61-73-4 39505 387 Fungicide, Dye Unclassified
    Metosulam 139528-85-1 NA 184 NA 184 Herbicide Unclassified
    Milorganite 68512-89-0 NA 66 3693 N/A Unclassified
    MKH 6561 NA 1466 NA 217 NA 216 Herbicide Unclassified
    MON 4660 71526-07-3 ##### NA 162 N/A Unclassified
    Monosodium glutamate 32221-81-1 NA 59 2691 N/A Unclassified
    Morwet EFW NA 36 NA 60 2693 Adjuvant Unclassified
    Morwet IP NA 568 NA 102 3694 Adjuvant Unclassified
    Morwet IP NA 887 NA 170 2694 Adjuvant Unclassified
    Multiresidue carbamate screen NA 848 NA 158 4042 N/A Unclassified
    Multiresidue chlorinated NA 847 NA 158 4043 N/A Unclassified
    hydrocarbon screen
    Multiresidue organophosphate NA 846 NA 158 4044 N/A Unclassified
    screen
    Multiresidue triazine screen NA 845 NA 157 4045 N/A Unclassified
    N,N-Diallyl-2,2- 37764-25-3 NA 187 NA 186 Herbicide Unclassified
    dichloroacetamide Safener
    n-Butyl acetate 142-62-1 ##### 2434 N/A Unclassified
    N-methyl-2-pyrrolidone 237900 NA 76 2684 N/A Unclassified
    N-TDF NA 22 NA 34 2713 N/A Unclassified
    Naphthalene-formaldehyde 9008-63-3 NA 58 2692 Insecticide, Unclassified
    condensate sulfonic acid, Fungicide,
    metallic salts Microbiocide,
    Adjuvant
    Naphthalic anhydride 81-84-5 NA 209 NA 208 Herbicide Unclassified
    Safener
    Neo-decanoic acid 26896-20-8 97501 2699 N/A Unclassified
    Neodol 25 63393-82-8 NA 51 3930 N/A Unclassified
    Neuessence powder 411669 NA 781 NA 140 3003 N/A Unclassified
    Nipyraclofen 99662-11-0 NA 229 NA 229 Herbicide Unclassified
    Nitrile rubber NA 743 NA 135 2704 N/A Unclassified
    Nitro ethane 79-24-3 NA 49 3298 Solvent Unclassified
    Nitromethane 75-52-5 NA 42 3299 Solvent Unclassified
    Nitrothal-isopropyl 10552-74-6 NA 181 NA 180 Fungicide Unclassified
    Non-ionic surfactants NA 1443 NA 214 NA 213 Soap/Surfactant, Unclassified
    Adjuvant
    Nonoxynol-9-phosphate NA 29 NA 43 2706 Adjuvant Unclassified
    Norbormide 991-42-4 86201 2711 N/A Unclassified
    Nuostabe v-1913 NA 23 NA 35 2715 N/A Unclassified
    Nuxtra calcium
    6% catalyst NA 25 NA 37 2716 N/A Unclassified
    Nuxtra calcium
    8% catalyst NA 26 NA 38 2717 N/A Unclassified
    Nuxtra manganese 9% catalyst NA 15 NA 24 2718 N/A Unclassified
    Nylon 32131-17-2 NA 25 3703 N/A Unclassified
    Octachlorostyrene 29082-74-4 NA 215 NA 215 N/A Unclassified
    Orvus ES paste concentrate NA 3 NA 3 2726 N/A Unclassified
    Ovex 80-33-1 20201 452 Insect Growth Unclassified
    Regulator
    Oxabetrinil 74782-23-3 NA 205 NA 204 Herbicide Unclassified
    Safener
    Oxadiargyl 39807-15-3 NA 211 NA 211 Herbicide Unclassified
    Oxapyrazon 4489-31-0 NA 209 NA 208 Herbicide Unclassified
    Oxapyrazon sodium 25316-56-7 NA 217 NA 217 Herbicide Unclassified
    Oxaziclomefone 153197-14-9 NA 233 NA 233 Herbicide Unclassified
    Oxidized polyethylene 68441-17-8 NA 118 3713 N/A Unclassified
    Oxygenated solvents NA 379 NA 687 1767 Solvent Unclassified
    p-Chloronitrobenzene 100-00-5 NA 183 NA 182 Insecticide Unclassified
    Paint NA 380 NA 688 3715 N/A Unclassified
    Panasol AN-2 NA 381 NA 690 2733 Solvent Unclassified
    Panasol AN-3 NA 382 NA 691 2732 Solvent Unclassified
    Paraformaldehyde 30525-89-4 43002 456 Microbiocide, Unclassified
    Fungicide,
    Insecticide
    Pareth 91-8 NA 889 NA 170 2734 N/A Unclassified
    Pentoxazone 110956-75-7 NA 233 NA 233 Herbicide Unclassified
    Perfluorooctane sulfonate NA 1456 NA 216 NA 215 Insecticide Unclassified
    Perfume 08-28 NA 750 NA 136 2740 Fragrance Unclassified
    Perfume bouquet no. 3 NA 366 NA 672 2741 Fragrance Unclassified
    Perfume, chem-mask C no. 280 NA 367 NA 673 2742 Fragrance Unclassified
    Perfume, colonial bouquet NA 368 NA 674 2744 Fragrance Unclassified
    8095
    Perfume, compound 2-2723 NA 752 NA 136 2745 Fragrance Unclassified
    Perfume, compound 44.368/g NA 370 NA 676 2747 Fragrance Unclassified
    Perfume, compound bouquet NA 369 NA 675 2746 Fragrance Unclassified
    EC
    Perfume, DL 10613 NA 823 NA 151 3888 Fragrance Unclassified
    Perfume, eaudesol mal NA 371 NA 677 2748 Fragrance Unclassified
    (special)
    Perfume, fragrance oil 6198 NA 372 NA 678 2750 Fragrance Unclassified
    AG
    Perfume, fresh meadows #651 NA 753 NA 136 2751 Fragrance Unclassified
    Perfume, herbal fragrance oil NA 354 NA 657 2753 Fragrance Unclassified
    no. 062
    Perfume, malamasque no. 59 NA 355 NA 658 2754 Fragrance Unclassified
    Perfume, malathion 21-639 NA 356 NA 659 2755 Fragrance Unclassified
    Perfume, marbelle 72160A NA 357 NA 660 2756 Fragrance Unclassified
    Perfume, mimosa no. 5 NA 754 NA 136 2757 Fragrance Unclassified
    Perfume, neutroleum alpha NA 358 NA 661 2758 Fragrance Unclassified
    Perfume, new mown hay NA 359 NA 662 2759 Fragrance Unclassified
    Perfume, norda EC-137 NA 360 NA 663 2760 Fragrance Unclassified
    Perfume, pet perfume # 27253 NA 361 NA 664 2761 Fragrance Unclassified
    Perfume, phase b-5 NA 755 NA 136 2762 Fragrance Unclassified
    Perfume, R-7402 NA 362 NA 665 2763 Fragrance Unclassified
    Perfume, veilex 40019 NA 363 NA 666 2764 Fragrance Unclassified
    Perfume, washroom cleaner NA 364 NA 667 2765 Fragrance Unclassified
    bouquet # 152-587
    Phenyl ether 101-84-8 NA 653 3324 N/A Unclassified
    Phosametine NA 1400 NA 197 NA 196 Herbicide Unclassified
    Phosdiphen 36519-00-3 NA 209 NA 209 Fungicide Unclassified
    Phosphoproteins NA 350 NA 646 1250 N/A Unclassified
    Phthalaldehyde 643-79-8 ##### 5107 Microbiocide Unclassified
    Phthalide 27355-22-2 NA 205 NA 205 Fungicide Unclassified
    Phthalo green NA 348 NA 642 2779 Dye Unclassified
    Picaridin NA 1434 NA 212 NA 211 Insect Unclassified
    Repellent
    Pigment blue 29 57455-37-5 NA 643 2780 Dye Unclassified
    Pigment green 7 1328-53-6 NA 636 3870 Dye Unclassified
    Pigment red 178 3049-71-6 NA 637 3869 Dye Unclassified
    Pigment red 57:1 6887-51-9 NA 171 3868 Dye Unclassified
    Pigment red no. 48 16013-44-8 NA 149 3729 Dye Unclassified
    Pimaricin 7681-93-8 NA 203 NA 202 Fungicide Unclassified
    Piperalin 3478-94-2 97003 488 Fungicide Unclassified
    Piperine 94-62-2 NA 223 NA 223 N/A Unclassified
    Piproctanyl 69309-47-3 NA 209 NA 209 Plant Growth Unclassified
    Regulator
    Piproctanyl bromide 56717-11-4 NA 218 NA 217 Plant Growth Unclassified
    Regulator
    Plastic polymers NA 339 NA 625 764 Adjuvant Unclassified
    Plurafac B-26 69227-21-0 NA 626 2782 N/A Unclassified
    Plurafac C-17 69227-21-0 NA 137 2783 N/A Unclassified
    Pluraflo E4A NA 340 NA 627 2784 Soap/Surfactant Unclassified
    Pluronic 10-R-5 NA 345 NA 632 2790 N/A Unclassified
    Pluronic 1-101 NA 759 NA 137 2788 N/A Unclassified
    Pluronic L-62 LF NA 342 NA 629 2786 N/A Unclassified
    Pluronic L61 NA 341 NA 628 2785 N/A Unclassified
    Pluronic 163 NA 343 NA 630 2787 N/A Unclassified
    Pluronic P-104 NA 344 NA 631 2789 N/A Unclassified
    PMS-5406-T pigment NA 346 NA 633 2791 N/A Unclassified
    Po-san 37339-61-0 98804 NA 861 N/A Unclassified
    Po-san 76930-44-4 98804 NA 862 N/A Unclassified
    Poly(oxyethylene) 31512-74-0 69183 1576 Microbiocide Unclassified
    (dimethylimino) ethylene
    (dimethylimino) ethylene
    dichloride
    Poly-i-para-menthene 34363-01-4 NA 610 1314 Insect Growth Unclassified
    Regulator
    Polyacrylamide polymer 2592984 NA 634 2111 Adjuvant Unclassified
    Polyalkylene ether NA 347 NA 635 2271 Adjuvant Unclassified
    Polyamide resin NA 621 NA 112 2795 N/A Unclassified
    Polyamine polymer NA 334 NA 620 1907 Adjuvant Unclassified
    Polyhexamethylene 32289-58-0 ##### 2258 Microbiocide, Unclassified
    biguanidine Fungicide
    Polymer emulsion K NA 329 NA 611 2804 Adjuvant Unclassified
    Polymerized acrylic acid 2592860 52902 3738 Adjuvant Unclassified
    Polyoxin 11113-80-7 NA 194 NA 193 Fungicide Unclassified
    Polyurethane NA 426 NA 768 3770 N/A Unclassified
    Polyvinyl butyral resin NA 427 NA 769 2820 N/A Unclassified
    Polyvinyl chloride 9002-86-2 NA 770 2821 N/A Unclassified
    Polyvinylpyrrolidone- 82010-83-1 43003 NA 367 Microbiocide Unclassified
    formaldehyde complex
    Polyvis O-SH NA 428 NA 771 2823 N/A Unclassified
    Poly[hydroxyethylene(dimethyliminio) NA 1512 NA 223 NA 222 Microbiocide Unclassified
    ethylene(dimethylimino)
    methylene dichloride]
    Potassium 3-(2-(2-((2-(2- NA 998 NA 779 3352 Preservative Unclassified
    hydroxy ethyl) ethyl) octadecyl
    amino)ethoxy) propionate
    Potassium N-ethyl perfluoro NA 997 NA 777 3354 Insecticide, Unclassified
    octane sulfonamide acetate Adjuvant
    Probenazole 27605-76-1 NA 205 NA 205 Fungicide, Unclassified
    Microbiocide
    Propellant A-46 NA 441 NA 794 2834 Propellant Unclassified
    Propellant A-70 NA 762 NA 137 2835 Propellant Unclassified
    Propellant A-91 NA 442 NA 795 2836 Propellant Unclassified
    Propellant B-46 NA 443 NA 796 3887 Propellant Unclassified
    Propidine NA 1449 NA 215 NA 214 Insect Unclassified
    Repellent
    Propionic acid 79-09-4 77702 505 Fungicide, Unclassified
    Microbiocide,
    Preservative
    Propyl-3-t-butylphenoxyacetate NA 1407 NA 198 NA 197 Plant Growth Unclassified
    Regulator
    Pyrazolynate 58011-68-0 NA 205 NA 205 Herbicide Unclassified
    Pyribenzoxim 168088-61-7 NA 233 NA 233 Herbicide Unclassified
    Pyriminobac 136191-56-5 NA 206 NA 205 Herbicide Unclassified
    Pyroquilone 57369-32-1 NA 190 NA 189 Fungicide Unclassified
    Quinacetol sulfate 57130-91-3 NA 210 NA 209 Fungicide Unclassified
    Quinizarin green SS 128-80-3 NA 109 3374 Dye Unclassified
    Quinoclamine 2797-51-5 NA 185 NA 184 Herbicide, Unclassified
    Algaecide
    Quinoxyfen 124495-18-7 NA 206 NA 205 Fungicide Unclassified
    Resins and polymers NA 1374 NA 194 NA 193 Pruning Aid, Unclassified
    Adjuvant
    RH - 2485 NA 1467 NA 217 NA 217 Insecticide Unclassified
    Rhodamine B 81-88-9 NA 138 2846 Dye Unclassified
    Sebacic acid 111-20-6 NA 187 NA 186 Repellent Unclassified
    Sec-butylamine 13952-84-6 4214 1704 Fungicide Unclassified
    Seconal 76-73-3 NA 190 NA 189 N/A Unclassified
    Secret formula no. 1 NA 2 NA 2 1837 N/A Unclassified,
    Unclassified
    Secret formula no. 2 NA 458 NA 820 1838 N/A Unclassified
    Silthiofam 175217-20-6 NA 210 NA 210 Fungicide Unclassified
    Sintofen 130561-48-7 NA 185 NA 184 Plant Growth Unclassified
    Regulator
    Sodium 2-ethylhexanoate 19766-89-3 NA 214 NA 214 Fungicide, Unclassified
    Microbiocide
    Sodium caprylate 29372 79063 3388 N/A Unclassified
    Sodium chloroacetate 3926-62-3 ##### NA 141 Herbicide Unclassified
    Sodium diacetoneketogulonate NA 1397 NA 197 NA 196 Plant Growth Unclassified
    Regulator
    Sodium gluconate 527-07-1 105 3406 N/A Unclassified
    Sodium methyl sulfate 512-42-5 NA 145 3417 N/A Unclassified
    Sodium petroleum sulfonate 68608-26-4 79035 3431 Insecticide, Unclassified
    Adjuvant
    Sodium propionate 137-40-6 77703 3434 Fungicide, Unclassified
    Preservative
    Solulan 98 NA 474 NA 874 2867 Solvent Unclassified
    Solulan L-575 NA 763 NA 138 2868 N/A Unclassified
    Solvent red 49 509-34-2 NA 875 3900 Dye Unclassified
    Spiroxamine 118134-30-8 NA 202 NA 202 Fungicide Unclassified
    Sponto 168 NA 484 NA 888 2875 N/A Unclassified
    Sponto 232T NA 492 NA 896 2885 N/A Unclassified
    Sponto 234T NA 766 NA 138 2886 N/A Unclassified
    Sponto AK-30-02BT NA 485 NA 889 2876 N/A Unclassified
    Sponto AK31-27A NA 764 NA 138 2877 N/A Unclassified
    Sponto AK31-27B NA 486 NA 890 2878 N/A Unclassified
    Sponto AK31-38 NA 487 NA 891 2879 N/A Unclassified
    Sponto AK31-56A NA 488 NA 892 2880 N/A Unclassified
    Sponto AK31-56B NA 765 NA 138 2881 N/A Unclassified
    Sponto AK31-56M NA 632 NA 116 3558 N/A Unclassified
    Sponto N-140B NA 489 NA 893 2882 N/A Unclassified
    Sponto N-300B NA 490 NA 894 2883 N/A Unclassified
    Sponto N-500B NA 491 NA 895 2884 N/A Unclassified
    Sta-pro 3000 NA 493 NA 897 2889 N/A Unclassified
    Stepan C-65 methyl ester NA 496 NA 903 2893 N/A Unclassified
    Stepantan A NA 497 NA 904 2894 N/A Unclassified
    Stepfac 8172 NA 767 NA 138 2895 N/A Unclassified
    Sterilix NA 656 NA 121 550 Microbiocide Unclassified
    Sterox NJ NA 498 NA 905 2896 N/A Unclassified
    Stoddard solvent 8052-41-3 63504 NA 516 Solvent, Unclassified
    Herbicide,
    Insecticide
    Styrene acrylic copolymer 25085-34-1 NA 907 3457 Adjuvant Unclassified
    Styrene/pvp copolymer 25086-29-7 NA 908 3812 Adjuvant Unclassified
    Sudan III 85-86-9 NA 909 3459 Dye Unclassified
    Sulcotrione 99105-77-8 NA 185 NA 184 Herbicide Unclassified
    Sulfated dipentane NA 500 NA 911 3460 N/A Unclassified
    Sulfonated cod liver oil NA 1464 NA 217 NA 216 N/A Unclassified
    Sulglycapin 51068-60-1 NA 233 NA 233 Herbicide Unclassified
    Sure sol 180 NA 505 NA 916 2903 Solvent Unclassified
    Surflo B11 NA 606 NA 110 2904 Soap/Surfactant Unclassified
    Surflo B13 NA 506 NA 917 2905 Soap/Surfactant Unclassified
    Surflo B16 NA 507 NA 918 2906 Soap/Surfactant Unclassified
    Surflo B17 NA 508 NA 919 2907 Soap/Surfactant Unclassified
    Surflo B19 NA 770 NA 139 2908 Soap/Surfactant Unclassified
    Sustane 3 NA 622 NA 113 2909 N/A Unclassified
    T-DETN-9.5 NA 513 NA 928 2917 N/A Unclassified
    T-mulz 565 NA 528 NA 955 2944 Adjuvant Unclassified
    T-mulz 94W NA 531 NA 958 2949 Adjuvant Unclassified
    T-mulz AO2 NA 772 NA 139 2943 N/A Unclassified
    T-mulz O NA 529 NA 956 2945 Adjuvant Unclassified
    T-mulz PB NA 530 NA 957 2946 Adjuvant Unclassified
    T-Mulz VO NA 610 NA 111 2947 N/A Unclassified
    T-mulz W NA 773 NA 139 2948 N/A Unclassified
    Tabu powder NA 510 NA 922 1462 N/A Unclassified
    Tacks NA 818 NA 151 3816 N/A Unclassified
    Tenneco 225F PVC resin NA 514 NA 930 2919 N/A Unclassified
    Tenneco T500-100 NA 771 NA 139 2920 N/A Unclassified
    Tenox 2 NA 515 NA 931 2921 Preservative Unclassified
    Tenox 4 NA 516 NA 932 2922 Preservative Unclassified
    Tenox R NA 517 NA 933 2923 Preservative Unclassified
    Tenox S-1 NA 518 NA 934 2924 Preservative Unclassified
    Tensiofix B7416 NA 895 NA 171 3943 Soap/Surfactant Unclassified
    Tensiofix B7453 NA 896 NA 171 3944 Soap/Surfactant Unclassified
    Tergitol 15-S-12 NA 623 NA 113 2926 N/A Unclassified
    Tergitol 15-S-12 acrylate NA 519 NA 935 2927 N/A Unclassified
    Tergitol 15-S-20 NA 520 NA 936 2928 N/A Unclassified
    tert-Butylamine Endothall 26648-01-1 38909 NA 327 Herbicide, Unclassified
    Defoliant
    Tetrahydrofuran 109-99-9 NA 944 2933 Solvent Unclassified
    Texaphor special NA 524 NA 951 2935 N/A Unclassified
    TF-310 NA 525 NA 952 3524 N/A Unclassified
    Thanite 115-31-1 47101 586 Insecticide Unclassified
    Thickener, unknown NA 526 NA 953 2936 Adjuvant Unclassified
    Thicyofen 116170-30-0 NA 210 NA 209 Fungicide Unclassified
    Thidiazimin 123249-43-4 NA 230 NA 229 Herbicide Unclassified
    Thiocyclam 31895-21-3 NA 182 NA 181 Insecticide Unclassified
    Thiocyclam hydrogen oxalate 31895-22-4 ##### NA 104 Insecticide Unclassified
    Thixatrol ST NA 820 NA 151 3853 N/A Unclassified
    Toximul 500 NA 532 NA 963 2951 Insecticide Unclassified
    Toximul 850 m NA 826 NA 152 3918 N/A Unclassified
    Toximul D NA 533 NA 964 2952 N/A Unclassified
    Toximul H NA 534 NA 965 2953 N/A Unclassified
    Toximul P NA 774 NA 140 2954 N/A Unclassified
    Toximul TA-5 NA 535 NA 966 2955 N/A Unclassified
    Triapenthenol 76608-88-3 NA 190 NA 189 Plant Growth Unclassified
    Regulator
    Triaryl methane NA 536 NA 967 2957 N/A Unclassified
    Triazoxide 72459-58-6 NA 185 NA 184 Fungicide Unclassified
    Tributyl phosphate 126-73-8 NA 969 3480 N/A Unclassified
    Trichlamide 70193-21-4 NA 210 NA 209 Fungicide Unclassified
    Trichloropyridinol NA 1338 NA 180 NA 179 Breakdown Unclassified
    product
    Tridemorph 24602-86-6 ##### NA 987 Fungicide Unclassified
    Tridemorph 81412-43-3 ##### NA 201 Fungicide Unclassified
    Triethyl phosphate 78-40-0 NA 979 3489 N/A Unclassified
    Trioxymethylene 110-88-3 NA 190 NA 189 Microbiocide, Unclassified
    Fungicide
    Triton CF-10 NA 542 NA 991 2968 Soap/Surfactant Unclassified
    Triton X-363 NA 612 NA 111 2969 Soap/Surfactant Unclassified
    Trycol NP-4 NA 775 NA 140 2970 N/A Unclassified
    Trycol NP-6 NA 543 NA 993 2971 N/A Unclassified
    Trycol NP-9 NA 544 NA 994 2972 N/A Unclassified
    Tryfac 5566 NA 545 NA 995 2973 N/A Unclassified
    Tryfac 910-K NA 546 NA 996 2974 N/A Unclassified
    Turgasept NA 776 NA 140 2975 N/A Unclassified
    Ucar solution vinyl VAGH NA 548 NA 999 2976 N/A Unclassified
    UL-94 HF1 listed polyester NA 549 NA 100 2977 N/A Unclassified
    foam
    Unknown (In EPA Product NA 1175 67323 NA 165 Fungicide Unclassified
    data w/o name)
    Unknown (In EPA Product NA 1176 69144 NA 165 Microbiocide Unclassified
    data w/o name)
    Unknown (In EPA Product NA 1177 69162 NA 165 Microbiocide Unclassified
    data w/o name)
    Unknown (In EPA Product NA 1178 79061 NA 165 Microbiocide Unclassified
    data w/o name)
    Unknown (In EPA Product NA 1179 ##### NA 166 Microbiocide Unclassified
    data w/o name)
    Unknown (In EPA Product NA 1180 ##### NA 166 Microbiocide Unclassified
    data w/o name)
    Unknown (In EPA Product NA 1181 ##### NA 166 Microbiocide Unclassified
    data w/o name)
    Unknown (In EPA Product NA 1182 ##### NA 166 N/A Unclassified
    data w/o name)
    Unknown (In EPA Product NA 1183 ##### NA 166 N/A Unclassified
    data w/o name)
    Urethane adhesive, parts a & b NA 551 NA 100 2979 N/A Unclassified
    Versalon 1112 NA 613 NA 111 2984 N/A Unclassified
    Versamid resins NA 651 NA 119 3822 N/A Unclassified
    Vinyl acetate 108-05-4 NA 100 2116 N/A Unclassified
    Vinyl polymer NA 680 NA 125 1754 Adjuvant Unclassified
    Vinyl resin, synthetic NA 554 NA 100 1533 N/A Unclassified
    Vitamin K3 58-27-5 6319 NA 89 N/A Unclassified
    Water soluble dyes NA 1517 NA 223 NA 223 Dye Unclassified
    Waxes NA 1376 NA 194 NA 194 Pruning Aid, Unclassified
    Adjuvant
    Wickenol 535 NA 779 NA 140 2989 N/A Unclassified
    Wing stay V NA 561 NA 101 2990 N/A Unclassified
    Witafrol 7420 NA 625 NA 113 2991 N/A Unclassified
    Witcamine tam-45 NA 562 NA 101 2992 N/A Unclassified
    Witco C-5752 NA 563 NA 101 3882 N/A Unclassified
    Witconate p-1020bu NA 614 NA 111 3884 N/A Unclassified
    Witconol 1S-108 NA 564 NA 101 2993 N/A Unclassified
    Zein 9010-66-6 NA 102 3504 N/A Unclassified

    *N/A = Not Available\
  • II. Augmenting the Sensitivity of Plants to Herbicides
  • In certain embodiments of the invention, the effectiveness of herbicides is augmented by methods and compositions for the contemporaneous administration of one or more ectophosphatase inhibitors in combination with herbicides. Such applications may, in addition to increasing the effectiveness of herbicides, allow the use of reduced concentrations of herbicides, thereby providing cost and environmental benefits.
  • Specifically contemplated by the invention are compositions comprising one or more ectophosphatase inhibitor(s) in combination with one or more herbicide(s) listed in Table 1. In one embodiment of the invention, the ectophosphatase inhibitor may or may not be a compound selected from formula I-XX. The herbicidal compositions or other compositions formulated for agricultural use, including compositions comprising insecticides and growth regulators, may be used with potentially any plant. The term “plant,” as used herein, refers to any type of plant. The inventors have provided below an exemplary description of some plants that may be used with the invention. However, the list is provided for illustrative purposes only and is not limiting, as other types of plants will be known to those of skill in the art and could be used with the invention.
  • Non-limiting examples of plant genera that may be treated in accordance with the invention include: Abutilon, Amaranthus, Artemisia, Asclepias, Avena, Axonopus, Borreria, Brachiaria, Brassica, Bromus, Chenopodium, Cirsium, Commelina, Convolvulus, Cynodon, Cyperus, Digitaria, Echinochloa, Eleusine, Elymus, Equisetum, Erodium, Helianthus, Imperata, Ipomoea, Kochia, Lolium, Malva, Oryza, Ottochloa, Panicum, Paspalum, Phalaris, Phragmites, Polygonum, Portulaca, Pteridium, Pueraria, Rubus, Salsola, Setaria, Sida, Sinapis, Sorghum, Triticum, Typha, Ulex, Xanthium, and Zea. Non-limiting common types of plants that may be controlled in accordance with the invention include varieties of grasses, broad leafs, succulents, trees and shrubs, barley, black nightshade, broadleaf signal grass, burcumber, chickweed, common ragweed, crabgrass, field pennycress, rough fleabane, foxtail, giant ragweed, goose grass, groundcherry, hemp sesbarria, henbit, jungle rice, kochia, lambs quarters, morning-glory spp., mustard, fall and Texas panicum, palma amaranth, prickly sida (teaweed), red rice, rye, seedling shattercone, shepherd's purse, sicklepod, sprangletop, sunflower, velvet leaf, volunteer corn, common and tall waterhemp, wheat, wild proso millet, witchgrass, wolly cupgrass; and common perennial weeds including Canada thistle, common milkweed, field bindweed, hemp dogbane, red vine, rhizone johnson grass, tall fescue, trumpet creeper, swamp smartweed and wisteria mukly. Star Thistle, Poison Oak, and Ivy.
  • Non-limiting examples of species that may be controlled include velvetleaf (Abutilon theophrasti), pigweed (Amaranthus spp.), buttonweed (Borreria spp.), oilseed rape, canola, indian mustard, etc. (Brassica spp.), commelina (Commelina spp.), filaree (Erodium spp.), sunflower (Helianthus spp.), morningglory (Ipomoea spp.), kochia (Kochia scoparia), mallow (Malva spp.), wild buckwheat, smartweed, etc. (Polygonum spp.), purslane (Portulaca spp.), russian thistle (Salsola spp.), sida (Sida spp.), wild mustard (Sinapis arvensis), cocklebur (Xanthium spp.), wild oat (Avena fatua), carpetgrass (Axonopus spp.), downy brome (Bromus tectorum), crabgrass (Digitaria spp.), barnyardgrass (Echinochloa crus-galli), goosegrass (Eleusine indica), annual ryegrass (Lolium multiflorum), rice (Oryza sativa), ottochloa (Ottochloa nodosa), bahiagrass (Paspalum notatum), canarygrass (Phalaris spp.), foxtail (Setania spp.), wheat (Triticum aestivum), corn (Zea mays), mugwort (Artemisia spp.), milkweed (Asclepias spp.), canada thistle (Cirsium arvense), field bindweed (Convolvulus arvensis), kudzu (Pueraria spp.), brachiaria (Brachiaria spp.), bermudagrass (Cynodon dactylon), yellow nutsedge (Cyperus esculentus), purple nutsedge (C. rotundus), quackgrass (Elymus repens), lalang (Imperata cylindrica), perennial ryegrass (Lolium perenne), guineagrass (Panicum maximum), dallisgrass (Paspalum dilatatum), reed (Phragmites spp.), johnsongrass (Sorghum halepense), cattail (Typha spp.), horsetail (Equisetum spp.), bracken (Pteridium aquilinum), blackberry (Rubus spp.) and gorse (Ulex europaeus).
  • Crop and other cultivated species may also be contacted with a composition of the invention. Non-limiting examples of cultivated plants include, but are not limited to, species from the genera Fragaria, Lotus, Medicago, Onobrychis, Trifolium, Trigonella, Vigna, Citrus, Linum, Geranium, Manihot, Daucus, Arabidopsis, Brassica, Raphanus, Sinapis, Atropa, Capsicum, Datura, Hyoscyamus, Lycopersicon, Nicotiana, Helianthus, Lactuca, Bromus, Asparagus, Antirrhinum, Hemerocallis, Nemesia, Pelargonium, Panicum, Pennisetum, Ranunculus, Senecio, Salpiglossis, Cucumis, Bromelia, Glycine, Lolium, Zea, Triticum, Sorghum, Ipomoea, Passifora, Cyclamen, Malus, Prumus, Rosa, Rubus, Populus, Santalum, Allium, Lilium, Narcissus, Ananas, Arachis, Phaseolus, Pisum, Oryza, Hordeum, Gossypium.
  • A common class of plants exploited in agriculture are vegetable crops, including artichokes, kohlrabi, arugula, leeks, asparagus, lettuce (e.g., head, leaf, romaine), bok choy, malanga, broccoli, melons (e.g., muskmelon, watermelon, crenshaw, honeydew, cantaloupe), brussels sprouts, cabbage, cardoni, carrots, napa, cauliflower, okra, onions, celery, parsley, chick peas, parsnips, chicory, Chinese cabbage, peppers, collards, potatoes, cucumber plants (marrows, cucumbers), pumpkins, cucurbits, radishes, dry bulb onions, rutabaga, eggplant, salsify, escarole, shallots, endive, garlic, spinach, green onions, squash, greens, beet (sugar beet and fodder beet), sweet potatoes, swiss-chard, horseradish, tomatoes, kale, turnips, and spices.
  • Other types of plants frequently finding commercial use include fruit and vine crops such as apples, apricots, cherries, nectarines, peaches, pears, plums, prunes, quince almonds, chestnuts, filberts, pecans, pistachios, walnuts, citrus, blueberries, boysenberries, cranberries, currants, loganberries, raspberries, strawberries, blackberries, grapes, avocados, bananas, kiwi, persimmons, pomegranate, pineapple, tropical fruits, pomes, melon, mango, papaya, and lychee.
  • Many of the most widely grown plants are field crop plants such as evening primrose, meadow foam, corn (field, sweet, popcorn), hops, jojoba, peanuts, rice, safflower, small grains (barley, oats, rye, wheat, etc.), sorghum, tobacco, kapok, leguminous plants (beans, lentils, peas, soybeans), oil plants (rape, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans, groundnuts), fiber plants (cotton, flax, hemp, jute), lauraceae (cinnamon, camphor), or plants such as coffee, sugarcane, tea, and natural rubber plants.
  • Another economically important group of plants are ornamental plants. Examples of commonly grown ornamental plants include alstroemeria (e.g., Alstoemeria brasiliensis), aster, azalea (e.g., Rhododendron sp.), begonias (e.g., Begonia sp.), bellflower, bouganvillea, cactus (e.g., Cactaceae schlumbergera truncata), camellia, carnation (e.g., Dianthus caryophyllus), chrysanthemums (e.g., Chrysanthemum sp.), clematis (e.g., Clematis sp.), cockscomb, columbine, cyclamen (e.g., Cyclamen sp.), daffodils (e.g., Narcissus sp.), false cypress, freesia (e.g., Freesia refracta), geraniums, gerberas, gladiolus (e.g., Gladiolus sp.), holly, hybiscus (e.g., Hibiscus rosasanensis), hydrangea (e.g., Macrophylla hydrangea), juniper, lilies (e.g., Lilium sp.), magnolia, miniroses, orchids (e.g., members of the family Orchidaceae), petunias (e.g., Petunia hybrida), poinsettia (e.g., Euphorbia pulcherima), primroses, rhododendron, roses (e.g., Rosa sp.), snapdragons (e.g., Antirrhinum sp.), shrubs, trees such as forest (broad-leaved trees and evergreens, such as conifers) and tulips (e.g., Tulipa sp.).
  • III. Antibiotics
  • Another embodiment of the invention concerns methods and compositions for the contemporaneous administration of ectophosphatase inhibitors and antibiotics. Antibiotics are any chemical of natural or synthetic origin that kill or inhibit the growth of other types cells. Many clinically-useful antibiotics are produced by microorganisms. Antibiotics are typically low molecular-weight (non-protein) molecules produced as secondary metabolites, mainly by microorganisms that live in the soil. Most of these microorganisms form some type of a spore or other dormant cell, and there is thought to be some relationship (besides temporal) between antibiotic production and the processes of sporulation. Among molds, the notable antibiotic producers are Penicillium and Cephalosporium, which are the main source of the beta-lactam antibiotics (penicillin and its relatives). In the Bacteria, the Actinomycetes, notably Streptomyces species, produce a variety of types of antibiotics including the aminoglycosides (e.g. streptomycin), macrolides (e.g. erythromycin), and the tetracyclines. Endospore-forming Bacillus species produce polypeptide antibiotics such as polymyxin and bacitracin. The table below (Table 1) is a summary of the classes of antibiotics and their properties including their biological sources.
  • As set forth in Table 2, certain aspects of the invention concern compositions comprising an ectophosphatase inhibitor and an antibiotic of a class selected from the group consisting of: beta-lactams (penicillins and cephalosporins); semisynthetic penicillin; clavulanic Acid; monobactams; carboxypenems; aminoglycosides; glycopeptides; lincomycins; macrolides; polypeptides; chloramphenicol; polyenes; rifamycins; tetracyclines; and semisynthetic tetracycline. Any ectophosphatase inhibitor may be used in conjuntion with these classes of antibiotics. In certain embodiments of the invention, the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulas I-XX.
    TABLE 2
    Classes of antibiotics and their properties
    Spectrum (effective
    Chemical class Examples Biological source against) Mode of action
    Beta-lactams Penicillin G, Penicillium notatum and Gram-positive bacteria Inhibits steps in cell wall
    (penicillins and Cephalothin Cephalosporium species (peptidoglycan) synthesis and
    cephalosporins) murein assembly
    Semisynthetic Ampicillin, Gram-positive and Gram- Inhibits steps in cell wall
    penicillin Amoxycillin negative bacteria (peptidoglycan) synthesis and
    murein assembly
    Clavulanic Acid Clavamox is Streptomyces clavuligerus Gram-positive and Gram- Suicide inhibitor of beta-lactamases
    clavulanic acid plus negative bacteria
    amoxycillin
    Monobactams Aztreonam Chromobacter violaceum Gram-positive and Gram- Inhibits steps in cell wall
    negative bacteria (peptidoglycan) synthesis and
    murein assembly
    Carboxypenems Imipenem Streptomyces cattleya Gram-positive and Gram- Inhibits steps in cell wall
    negative bacteria (peptidoglycan) synthesis and
    murein assembly
    Aminoglycosides Streptomycin Streptomyces griseus Gram-positive and Gram- Inhibit translation (protein synthesis)
    negative bacteria
    Gentamicin Micromonospora species Gram-positive and Gram- Inhibit translation (protein synthesis)
    negative bacteria esp.
    Pseudomonas
    Glycopeptides Vancomycin Streptomyces orientales Gram-positive bacteria, Inhibits steps in murein
    esp. Staphylococcus (peptidoglycan) biosynthesis and
    aureus assembly
    Lincomycins Clindamycin Streptomyces lincolnensis Gram-positive and Gram- Inhibits translation (protein
    negative bacteria esp. synthesis)
    anaerobic Bacteroides
    Macrolides Erythromycin Streptomyces erythreus Gram-positive bacteria, Inhibits translation (protein
    Gram-negative bacteria synthesis)
    not enterics,
    Neisseria, Legionella,
    Mycoplasma
    Polypeptides Polymyxin Bacillus polymyxa Gram-negative bacteria Damages cytoplasmic membranes
    Bacitracin Bacillus subtilis Gram-positive bacteria Inhibits steps in murein
    (peptidoglycan) biosynthesis and
    assembly
    Polyenes Amphotericin Streptomyces nodosus Fungi Inactivate membranes containing
    sterols
    Nystatin Streptomyces noursei Fungi (Candida) Inactivate membranes containing
    sterols
    Rifamycins Rifampicin Streptomyces mediterranei Gram-positive and Gram- Inhibits transcription (eubacterial
    negative bacteria, RNA polymerase)
    Mycobacterium
    tuberculosis
    Tetracyclines Tetracycline Streptomyces species Gram-positive and Gram- Inhibit translation (protein synthesis)
    negative bacteria,
    Rickettsias
    Semisynthetic Doxycycline Gram-positive and Gram- Inhibit translation (protein synthesis)
    tetracycline negative bacteria,
    Rickettsias Ehrlichia,
    Borellia
    Chloramphenicol Chloramphenicol Streptomyces venezuelae Gram-positive and Gram- Inhibits translation (protein
    negative bacteria synthesis)
  • A. Antimicrobial Agents Used in the Treatment of Infectious Disease
  • An important property of a clinically-useful antimicrobial agent, especially from the patient's point of view, is its selective toxicity, i.e., that the agent acts in some way that inhibits or kills bacterial pathogens but has little or no toxic effect on the animal taking the drug. This implies that the biochemical processes in the bacteria are in some way different from those in the animal cells, and that the advantage of this difference can be taken in chemotherapy. Antibiotics may have a cidal (killing) effect or a static (inhibitory) effect on a range of microbes. The range of bacteria or other microorganisms that are affected by a certain antibiotic are is expressed as its spectrum of action. Antibiotics effective against prokaryotes which kill or inhibit a wide range of Gram-positive and Gram-negative bacteria are said to be broad spectrum. If effective mainly against Gram-positive or Gram-negative bacteria, they are narrow spectrum. If effective against a single organism or disease, they are referred to as limited spectrum. In accordance with the invention, certain adverse effects of antibiotics may be minimized by use of en ectophosphatase inhibitor in combination with the antibiotic, thereby allowing use of lower doses of antibiotics.
  • B. Kinds of Antimicrobial Agents and Their Primary Modes of Action
  • In one embodiment of the invention, ectophosphatase inhibitors are used in conjunction with cell wall synthesis inhibitors. Cell wall synthesis inhibitors generally inhibit some step in the synthesis of bacterial peptidoglycan. Generally they exert their selective toxicity against eubacteria because human cells lack cell walls.
  • Beta lactam antibiotics contain a 4-membered beta lactam ring. They are the products of two groups of fungi, Penicillium and Cephalosporium molds, and are correspondingly represented by the penicillins and cephalosporins. The beta lactam antibiotics inhibit the last step in peptidoglycan synthesis, the final cross-linking between peptide side chains, mediated by bacterial carboxypeptidase and transpeptidase enzymes. Beta lactam antibiotics are normally bactericidal and require that cells be actively growing in order to exert their toxicity.
  • Natural penicillins, such as Penicillin G or Penicillin V, are produced by fermentation of Penicillium chrysogenum. They are effective against streptococcus, gonococcus and staphylococcus, except where resistance has developed. They are considered narrow spectrum since they are not effective against Gram-negative rods.
  • Semisynthetic penicillins date to 1959. Mold produces a main part of the penicillin molecule (6-aminopenicillanic acid) which can be modified chemically by the addition of side chains. Many of these compounds have been developed to have distinct benefits or advantages over penicillin G, such as increased spectrum of activity (effectiveness against Gram-negative rods), resistance to penicillinase, effectiveness when administered orally, etc. Amoxycillin and Ampicillin have broadened spectra against Gram-negatives and are effective orally; Methicillin is penicillinase-resistant.
  • Clavulanic acid is a chemical sometimes added to a semisynthetic penicillin preparation. Thus, amoxycillin plus clavulanate is clavamox or augmentin. The clavulanate is not an antimicrobial agent. It inhibits beta lactamase enzymes and has given extended life to penicillinase-sensitive beta lactams.
  • Although nontoxic, penicillins occasionally cause death when administered to persons who are allergic to them. In the U.S. there are 300-500 deaths annually due to penicillin allergy. In allergic individuals the beta lactam molecule attaches to a serum protein which initiates an IgE-mediated inflammatory response.
  • Cephalolsporins are beta lactam antibiotics with a similar mode of action to penicillins that are produced by species of Cephalosporium. The have a low toxicity and a somewhat broader spectrum than natural penicillins. They are often used as penicillin substitutes, against Gram-negative bacteria, and in surgical prophylaxis. They are subject to degradation by some bacterial beta-lactamases, but they tend to be resistant to beta-lactamases from S. aureus.
  • Bacitracin is a polypeptide antibiotic produced by Bacillus species. It prevents cell wall growth by inhibiting the release of the muropeptide subunits of peptidoglycan from the lipid carrier molecule that carries the subunit to the outside of the membrane Teichoic acid synthesis, which requires the same carrier, is also inhibited. Bacitracin has a high toxicity which precludes its systemic use. It is present in many topical antibiotic preparations, and since it is not absorbed by the gut, it is given to “sterilize” the bowel prior to surgery.
  • Cell membrane inhibitors disorganize the structure or inhibit the function of bacterial membranes. The integrity of the cytoplasmic and outer membranes is vital to bacteria, and compounds that disorganize the membranes rapidly kill the cells. However, due to the similarities in phospholipids in eubacterial and eukaryotic membranes, this action is rarely specific enough to permit these compounds to be used systemically. The only antibacterial antibiotic of clinical importance that acts by this mechanism is Polymyxin, produced by Bacillus polymyxis. Polymyxin is effective mainly against Gram-negative bacteria and is usually limited to topical usage. Polymyxins bind to membrane phospholipids and thereby interfere with membrane function. Polymyxin is occasionally given for urinary tract infections caused by Pseudomonas that are gentamicin, carbenicillin and tobramycin resistant. The balance between effectiveness and damage to the kidney and other organs is dangerously close, and the drug should only be given under close supervision in the hospital.
  • In accordance with the invention, ectophosphatase inhibitors may also be contemporaneously administered and formulated in compositions with antibiotics that are protein synthesis inhibitors. Many therapeutically useful antibiotics inhibit some step in the complex process of translation. The attack is at one of the events occurring on the ribosome, rather than the stage of amino acid activation or attachment to a particular tRNA. Most have an affinity or specificity for 70S (as opposed to 80S) ribosomes, and they achieve their selective toxicity in this manner. The most important antibiotics with this mode of action are the tetracyclines, chloramphenicol, the macrolides (e.g. erythromycin) and the aminoglycosides (e.g. streptomycin).
  • The aminoglycosides are products of Streptomyces species and are represented by streptomycin, kanamycin, tobramycin and gentamicin. These antibiotics exert their activity by binding to bacterial ribosomes and preventing the initiation of protein synthesis. Aminoglycosides have been used against a wide variety of bacterial infections caused by Gram-positive and Gram-negative bacteria. Streptomycin has been used extensively as a primary drug in the treatment of tuberculosis. Gentamicin is active against many strains of Gram-positive and Gram-negative bacteria, including some strains of Pseudomonas aeruginosa. Kanamycin (a complex of three antibiotics, A, B and C) is active at low concentrations against many Gram-positive bacteria, including penicillin-resistant staphylococci. Gentamicin and Tobramycin are mainstays for treatment of Pseudomonas infections. An unfortunate side effect of aminoglycosides has tended to restrict their usage: prolonged use is known to impair kidney function and cause damage to the auditory nerves leading to deafness.
  • The tetracyclines consist of eight related antibiotics which are all natural products of Streptomyces, although some can now be produced semisynthetically. Tetracycline, chlortetracycline and doxycycline are the best known. The tetracyclines are broad-spectrum antibiotics with a wide range of activity against both Gram-positive and Gram-negative bacteria. The tetracyclines act by blocking the binding of aminoacyl tRNA to the A site on the ribosome. Tetracyclines inhibit protein synthesis on isolated 70S or 80S (eukaryotic) ribosomes, and in both cases, their effect is on the small ribosomal subunit. However, most bacteria possess an active transport system for tetracycline that will allow intracellular accumulation of the antibiotic at concentrations 50 times as great as that in the medium. This greatly enhances its antibacterial effectiveness and accounts for its specificity of action, since an effective concentration cannot be accumulated in animal cells. Thus a blood level of tetracycline which is harmless
  • The tetracyclines have a remarkably low toxicity and minimal side effects when taken by animals. The combination of their broad spectrum and low toxicity has led to their overuse and misuse by the medical community and the wide-spread development of resistance has reduced their effectiveness. Nonetheless, tetracyclines still have some important uses, such as in the treatment of Lyme disease.
  • Chloramphenicol has a broad spectrum of activity but it exerts a bacteriostatic effect. It is effective against intracellular parasites such as the rickettsiae. Unfortunately, aplastic anemia, which is dose related develops in a small proportion (1/50,000) of patients. Chloramphenicol was originally discovered and purified from the fermentation of a Streptomyces, but currently it is produced entirely by chemical synthesis. Chloramphenicol inhibits the bacterial enzyme peptidyl transferase thereby preventing the growth of the polypeptide chain during protein synthesis.
  • Chloramphenicol is entirely selective for 70S ribosomes and does not affect 80S ribosomes. Its unfortunate toxicity towards the small proportion of patients who receive it is in no way related to its effect on bacterial protein synthesis. However, since mitochondria probably originated from prokaryotic cells and have 70S ribosomes, they are subject to inhibition by some of the protein synthesis inhibitors including chloroamphenicol. This likely explains the toxicity of chloramphenicol. The eukaryotic cells most likely to be inhibited by chloramphenicol are those undergoing rapid multiplication, thereby rapidly synthesizing mitochondria. Such cells include the blood forming cells of the bone marrow, the inhibition of which could present as aplastic anemia. Chloramphenicol was once a highly prescribed antibiotic and a number of deaths from anemia occurred before its use was curtailed. Now it is seldom used in human medicine except in life-threatening situations (e.g. typhoid fever).
  • The Macrolides are a family of antibiotics whose structures contain large lactone rings linked through glycoside bonds with amino sugars. The most important members of the group are erythromycin and oleandomycin. Erythromycin is active against most Gram-positive bacteria, Neisseria, Legionella and Haemophilus, but not against the Enterobacteriaceae. Macrolides inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit. Binding inhibits elongation of the protein by peptidyl transferase or prevents translocation of the ribosome or both. Macrolides are bacteriostatic for most bacteria but are cidal for a few Gram-positive bacteria.
  • In further embodiments of the invention, ectophosphatase inhibitors may be contemporaneously administered and formulated in compositions with antibiotics that affect nucleic acids, including chemotherapeutic agents that affect the synthesis of DNA or RNA, or can bind to DNA or RNA so that their messages cannot be read. In either case, this can block the growth of cells. The majority of these drugs are unselective, however, and affect animal cells and bacterial cells alike and therefore have no therapeutic application. Two nucleic acid synthesis inhibitors which have selective activity against prokaryotes and some medical utility are nalidixic acid and rifamycins.
  • Nalidixic acid is a synthetic chemotherapeutic agent which has activity mainly against Gram-negative bacteria. Nalidixic acid belongs to a group of compounds called quinolones. Nalidixic acid is a bactericidal agent that binds to the DNA gyrase enzyme (topoisomerase) which is essential for DNA replication and allows supercoils to be relaxed and reformed. Binding of the drug inhibits DNA gyrase activity.
  • Some quinolones penetrate macrophages and neutrophils better than most antibiotics and are thus useful in treatment of infections caused by intracellular parasites. However, the main use of nalidixic acid is in treatment of lower urinary tract infections (UTI). The compound is unusual in that it is effective against several types of Gram-negative bacteria such as E. coli, Enterobacter aerogentes, K. pneumoniae and Proteus species which are common causes of UTI. It is not usually effective against Pseudomonas aeruginosa, and Gram-positive bacteria are resistant.
  • The rifamycins are also the products of Streptomyces. Rifampicin is a semisynthetic derivative of rifamycin that is active against Gram-positive bacteria (including Mycobacterium tuberculosis) and some Gram-negative bacteria. Rifampicin acts quite specifically on eubacterial RNA polymerase and is inactive towards RNA polymerase from animal cells or towards DNA polymerase. The antibiotic binds to the beta subunit of the polymerase and apparently blocks the entry of the first nucleotide which is necessary to activate the polymerase, thereby blocking mRNA synthesis. It has been found to have greater bactericidal effect against M. tuberculosis than other anti-tuberculosis drugs, and it has largely replaced isoniazid as one of the front-line drugs used to treat the disease, especially when isoniazid resistance is indicated. It is effective orally and penetrates well into the cerebrospinal fluid and is therefore useful for treatment of tuberculosis meningitis and meningitis caused by Neisseria meningitidis.
  • In accordance with the invention, ectophosphatase inhibitors may also be administered with competitive inhibitors, including mostly all synthetic chemotherapeutic agents. Most are “growth factor analogs” which are structurally similar to a bacterial growth factor but which do not fulfill its metabolic function in the cell. Some are bacteriostatic and some are bactericidal.
  • Sulfonamides were originally introduced as chemotherapeutic agents, one of which, prontosil, had the effect of curing mice with infections caused by beta-hemolytic streptococci. Chemical modifications of the compound sulfanilamide gave compounds with even higher and broader antibacterial activity. The resulting sulfonamides have broadly similar antibacterial activity, but differ widely in their pharmacological actions. Bacteria which are almost always sensitive to the sulfonamides include Streptococcus pneumoniae, beta-hemolytic streptococci and E. coli. The sulfonamides have been extremely useful in the treatment of uncomplicated UTI caused by E. coli, and in the treatment of meningococcal meningitis, because they cross the blood-brain barrier.
  • The sulfonamides (e.g. Gantrisin) and Trimethoprim are inhibitors of the bacterial enzymes required for the synthesis of tetrahydofolic acid (THF), the vitamin form of folic acid essential for 1-carbon transfer reactions. Sulfonamides are structurally similar to para aminobenzoic acid (PABA), the substrate for the first enzyme in the THF pathway, and they competitively inhibit that step. Trimethoprim is structurally similar to dihydrofolate (DHF) and competitively inhibits the second step in THF synthesis mediated by the DHF reductase. Animal cells do not synthesize their own folic acid but obtain it in a preformed fashion as a vitamin. Since animals do not make folic acid, they are not affected by these drugs, which achieve their selective toxicity for bacteria on this basis.
  • Three additional synthetic chemotherapeutic agents have been used in the treatment of tuberculosis: isoniazid (INH), paraaminosalicylic acid (PAS), and ethambutol. The usual strategy in the treatment of tuberculosis has been to administer a single antibiotic (historically streptomycin, but now, most commonly, rifampicin is given) in conjunction with INH and ethambutol. Since the tubercle bacillus rapidly develops resistance to the antibiotic, ethambutol and INH are given to prevent outgrowth of a resistant strain. It must also be pointed out that the tubercle bacillus rapidly develops resistance to ethambutol and INH if either drug is used alone. Ethambutol inhibits incorporation of mycolic acids into the mycobacterial cell wall. Isoniazid has been reported to inhibit mycolic acid synthesis in mycobacteria and since it is an analog of pyridoxine (Vitamin B6) it may inhibit pyridoxine catalyzed reactions as well. Isoniazid is activated by a mycobacterial peroxidase enzyme and destroys several targets in the cell. PAS is an anti-folate. PAS was once a primary anti-tuberculosis drug, but now it is a secondary agent, having been largely replaced by ethambutol.
  • C. Inhibition of Drug Resistance in Microorganisms to Treat Infection
  • The present invention also relates to methods for inhibiting or ameliorating infection in animals and humans caused by microorganisms. For example, treatment of bacterial and fungal infections may be augmented or effected using inhibitory mechanisms against an ectophosphatase to modify the ATP gradient across biological membranes. The invention is useful in the inhibition or amelioration of a wide range of infections including, but not limited to, gram negative bacterial infection including gram-negative sepsis, gram-negative endotoxin-related hypotension and shock, rabies, cholera, tetanus, lymes disease, tuberculosis, Candida albicans, Chlamydia, etc.
  • The inhibition or amelioration of the infections may involve the administration of an anti-microbial agent (such as an antibiotic or an antifungal agent) with the concurrent administration of the aforementioned compositions. Additionally, inhibitors of ectophosphatases or ABC transporters may be administered via a physiologically acceptable carrier as described above. In one embodiment of the invention, the inhibitor of ectophosphatase is selected from the compounds represented by formulas I-XX.
  • Certain aspects of the current invention thus concern the inhibition of cell growth by contacting a cell with an inhibitor of an ectophosphatase with contemporaneous administration of other agents capable of inhibiting cell growth or killing the cell. In this manner, therapeutic benefit may be obtained for the treatment of bacterial infections. Examples of types of bacteria that could be inhibited and bacterial infections that could potentially be treated or prevented with the invention, include, but are not limited to, the 83 or more distinct serotypes of pneumococci, streptococci such as S. pyogenes, S. agalactiae, S. equi, S. canis, S. bovis, S. equinus, S. anginosus, S. sanguis, S. salivarius, S. mitis, S. mutans, other viridans streptococci, peptostreptococci, other related species of streptococci, enterococci such as Enterococcus faecalis, Enterococcus faecium, Staphylococci, such as Staphylococcus epidermidis, Staphylococcus aureus, particularly in the nasopharynx, Hemophilus influenzae, pseudomonas species such as Pseudomonas aeruginosa, Pseudomonas pseudomallei, Pseudomonas mallei, brucellas such as Brucella melitensis, Brucella suis, Brucella abortus, Bordetella pertussis, Neisseria meningitidis, Neisseria gonorrhoeae, Moraxella catarrhalis, Corynebacterium diphtheriae, Corynebacterium ulceratis, Corynebacterium pseudotuberculosis, Corynebacterium pseudodiphtheriticum, Corynebacterium urealyticum, Corynebacterium hemolyticum, Corynebacterium equi, etc. Listeria monocytogenes, Nocordia asteroides, Bacteroides species, Actinomycetes species, Treponema pallidum, Leptospirosa species and related organisms. The invention may also find use, for example, against gram negative bacteria such as Klebsiella pneumoniae, Escherichia coli, Proteus, Serratia species, Acinetobacter, Yersinia pestis, Francisella tularensis, Enterobacter species, Bacteriodes and Legionella species and the like.
  • IV. Chemotherapeutics
  • A variety of chemotherapeutic agents are suitable for use with the invention and are known to those of skill in the art. In accordance with the invention, therapeutic benefit may be obtained by contemporaneous administration of one or more ectophosphatase inhibitor and one or more such chemotherapeutic agent(s). Co-administration of chemotherapeutics with ectophosphatase inhibitors in accordance with the invention may be used to increase therapeutic effectiveness of a chemotherapeutic and may allow use of lowered doses. Such techniques may further allow treatment of chemotherapy-resistant tumor cells.
  • As will be understood by those of ordinary skill in the art, the appropriate doses of chemotherapeutic agents will be generally around those already employed in clinical therapies wherein the chemotherapeutics are administered alone or in combination with other chemotherapeutics. By way of example only, agents such as cisplatin, and other DNA alkylating agents may be used with an ectophosphatase inhibitor. Cisplatin has been widely used to treat cancer, with efficacious doses used in clinical applications of 20 mg/m2 for 5 days every three weeks for a total of three courses. Cisplatin is not absorbed orally and must therefore be delivered via injection intravenously, subcutaneously, intratumorally or intraperitoneally.
  • Further agents for use with ectophosphatase inhibitors in accordance with the invention include, for example, compounds that interfere with DNA replication, mitosis and chromosomal segregation. Such chemotherapeutic compounds include adriamycin, also known as doxorubicin, etoposide, verapamil, podophyllotoxin, and the like. Widely used in a clinical setting for the treatment of neoplasms, these compounds are administered through bolus injections intravenously at doses ranging from 25-75 mg/m2 at 21 day intervals for adriamycin, to 35-50 mg/m2 for etoposide intravenously or double the intravenous dose orally.
  • Agents that disrupt the synthesis and fidelity of polynucleotide precursors also may be used with ectophosphatase inhibitors. Particularly useful are agents that have undergone extensive testing and are readily available. As such, agents such as 5-fluorouracil (5-FU) are preferentially used by neoplastic tissue, making this agent particularly useful for targeting to neoplastic cells. Although quite toxic, 5-FU is applicable in a wide range of carriers, including topical, with intravenous administration in doses ranging from 3 to 15 mg/kg/day being commonly used.
  • Exemplary and non-limiting chemotherapeutic agents for use in combination with an ectophosphatase inhibitor in accordance with the invention are listed in Table 3. Accordingly, compositions comprising these agents and one or more ectophosphatase inhibitor(s) form one part of the invention, as do methods for the administration thereof. Each of the agents listed below are exemplary and by no means limiting. In this regard, the skilled artisan is directed to “Remington's Pharmaceutical Sciences” 15th Edition, chapter 33, in particular pages 624-652. Some variation in dosage will necessarily occur depending on the condition of the subject being treated. The person responsible for administration will, in any event, determine the appropriate dose for the individual subject. Moreover, for human administration, preparations should meet sterility, pyrogenicity, general safety and purity standards as required by FDA Office of Biologics standards.
  • Specifically contemplated by the inventors are compositions comprising and ectophosphatase inhibitor and a chemotherapeutic agent set forth in Table 3, as well as methods comprising the use thereof
    TABLE 3
    Chemotherapeutic Agents Useful In Neoplastic Disease
    NONPROPRIETARY
    TYPE OF NAMES
    CLASS AGENT (OTHER NAMES) DISEASE
    Mechlorethamine (HN2) Hodgkin's disease,
    non-Hodgkin's lymphomas
    Nitrogen Cyclophosphamide Acute and chronic
    Mustards Ifosfamide lymphocytic leukemias,
    Hodgkin's disease,
    non-Hodgkin's lymphomas,
    multiple myeloma,
    neuroblastoma, breast, ovary,
    lung, Wilms' tumor, cervix,
    testis, soft-tissue sarcomas
    Melphalan (L-sarcolysin) Multiple myeloma, breast,
    ovary
    Chlorambucil Chronic lymphocytic
    leukemia, primary
    macroglobulinemia,
    Hodgkin's disease,
    non-Hodgkin's lymphomas
    Alkylating Ethylenimenes Hexamethylmelamine Ovary
    Agents and
    Methylmelamines
    Thiotepa Bladder, breast, ovary
    Alkyl Busulfan Chronic granulocytic leukemia
    Sulfonates
    Carmustine (BCNU) Hodgkin's disease,
    non-Hodgkin's lymphomas,
    primary brain tumors, multiple
    myeloma, malignant
    melanoma
    Nitrosoureas Lomustine (CCNU) Hodgkin's disease,
    non-Hodgkin's lymphomas,
    primary brain tumors,
    small-cell lung
    Semustine Primary brain tumors,
    (methyl-CCNU) stomach, colon
    Streptozocin Malignant pancreatic
    (streptozotocin) insulinoma, malignant
    carcinoid
    Triazines Dacarbazine (DTIC; Malignant melanoma,
    dimethyltriazenoimidazolecarboxamide) Hodgkin's disease, soft-tissue
    sarcomas
    Antimetabolites Folic Acid Methotrexate Acute lymphocytic leukemia,
    Analogs (amethopterin) choriocarcinoma, mycosis
    fungoides, breast, head and
    neck, lung, osteogenic
    sarcoma
    Pyrimidine Fluouracil Breast, colon, stomach,
    Analogs (5-fluorouracil; 5-FU) pancreas, ovary, head and
    Floxuridine neck, urinary bladder,
    (fluorode-oxyuridine; premalignant skin lesions
    FUdR) (topical)
    Antimetabolites, Cytarabine (cytosine Acute granulocytic and acute
    continued arabinoside) lymphocytic leukemias
    Mercaptopurine Acute lymphocytic, acute
    (6-mercaptopurine; granulocytic and chronic
    6-MP) granulocytic leukemias
    Purine Analogs Thioguanine Acute granulocytic, acute
    and Related (6-thioguanine; TG) lymphocytic and chronic
    Inhibitors granulocytic leukemias
    Pentostatin Hairy cell leukemia, mycosis
    (2-deoxycoformycin) fungoides, chronic
    lymphocytic leukemia
    Vinblastine (VLB) Hodgkin's disease,
    non-Hodgkin's lymphomas,
    breast, testis
    Vinca Alkaloids Vincristine Acute lymphocytic leukemia,
    neuroblastoma, Wilms' tumor,
    rhabdomyosarcoma,
    Hodgkin's disease,
    non-Hodgkin's lymphomas,
    small-cell lung
    Epipodophyllotoxins Etoposide Testis, small-cell lung and
    Tertiposide other lung, breast, Hodgkin's
    disease, non-Hodgkin's
    lymphomas, acute
    granulocytic leukemia,
    Kaposi's sarcoma
    Natural Dactinomycin Choriocarcinoma, Wilms'
    Products (actinomycin D) tumor, rhabdomyosarcoma,
    testis, Kaposi's sarcoma
    Daunorubicin Acute granulocytic and acute
    (daunomycin; lymphocytic leukemias
    rubidomycin)
    Antibiotics Doxorubicin Soft-tissue, osteogenic and
    other sarcomas; Hodgkin's
    disease, non-Hodgkin's
    lymphomas, acute leukemias,
    breast, genitourinary, thyroid,
    lung, stomach, neuroblastoma
    Bleomycin Testis, head and neck, skin,
    esophagus, lung and
    genitourinary tract; Hodgkin's
    disease, non-Hodgkin's
    lymphomas
    Antibiotics, Plicamycin Testis, malignant
    continued (mithramycin) hypercalcemia
    Natural Mitomycin (mitomycin Stomach, cervix, colon, breast,
    Products, C) pancreas, bladder, head and
    continued neck
    Enzymes L-Asparaginase Acute lymphocytic leukemia
    Biological Interferon alfa Hairy cell leukemia., Kaposi's
    Response sarcoma, melanoma,
    Modifiers carcinoid, renal cell, ovary,
    bladder, non-Hodgkin's
    lymphomas, mycosis
    fungoides, multiple myeloma,
    chronic granulocytic leukemia
    Platinum Cisplatin (cis-DDP) Testis, ovary, bladder, head
    Coordination Carboplatin and neck, lung, thyroid,
    Complexes cervix, endometrium,
    neuroblastoma, osteogenic
    sarcoma
    Anthracenedione Mitoxantrone Acute granulocytic leukemia,
    breast
    Miscellaneous Substituted Urea Hydroxyurea Chronic granulocytic
    Agents leukemia, polycythemia vera,
    essental thrombocytosis,
    malignant melanoma
    Methyl Procarbazine Hodgkin's disease
    Hydrazine (N-methylhydrazine,
    Derivative MIH)
    Adrenocortical Mitotane (o, p′-DDD) Adrenal cortex
    Suppressant Aminoglutethimide Breast
    Adrenocorticosteroids Prednisone (several other Acute and chronic
    equivalent preparations lymphocytic leukemias,
    available) non-Hodgkin's lymphomas,
    Hodgkin's disease, breast
    Hormones and Progestins Hydroxyprogesterone Endometrium, breast
    Antagonists caproate
    Medroxyprogesterone
    acetate
    Megestrol acetate
    Estrogens Diethylstilbestrol Breast, prostate
    Ethinyl estradiol (other
    preparations available)
    Antiestrogen Tamoxifen Breast
    Androgens Testosterone propionate Breast
    Fluoxymesterone (other
    preparations available)
    Antiandrogen Flutamide Prostate
    Gonadotropin-releasing Leuprolide Prostate
    hormone
    analog
  • Administration of compositions provided by the invention may be local or systemic, using a suitable physiological carrier. Other compounds which aid in the uptake or stability of these agents, or which have beneficial activity, may also be included in the formulations of the invention. Certain embodiments of the invention thus provide pharmaceutical composition comprising an ectophosphatase inhibitor. The composition may further comprise, in certain embodiments, a cytotoxic agent, including a chemotherapeutic agent set forth herein. For example, by contacting a tumor cell either alone with the ectophosphatase inhibitor or in combination with one or more chemotherapeutic agents, therapeutic benefit may be obtained. Particular benefit may be obtained where a tumor cell is resistant to at least one chemotherapeutic agent. This may enhance the overall anti-tumor activity achieved by therapy, and/or may be used to prevent or combat multi-drug tumor resistance.
  • V. Assays and Methods for Screening Active Compounds
  • In one embodiment of the invention, assays are provided for screening compositions comprising combinations of ectophosphatase inhibitors and a selected cytotoxic agent, for example, a herbicide, fungicide, antibiotic, insecticide or chemotherapeutic agent. A number of assay formats are known to those of skill in the art and may be used in this regard. These include assays of biological activities as well as assays of chemical properties. The results of these assays provide important inferences as to the properties of compounds as well as their potential applications in treating human or other mammalian patients for infection and hyperproliferative diseases as well as in various agricultural applications. Assays deemed to be of particular utility in this regard include in vivo and in vitro screens of activity and immunoassays.
  • (i) Screening for Herbicidal Activity
  • One aspect of the current invention provides herbicidal compositions having improved herbicidal activity. In accordance with the invention, assays for herbicidal activity may be used to asses the relative efficacy of combinations of ectophosphatase inhibitors and herbicidal agents. Numerous assays formats for analyzing herbicidal activity are known to those of skill in the art and may be used in this regard. A straightforward means for testing activity comprises the serial application of test compositions to plants and/or plant parts, for example, by leaf painting. Plants are otherwise grown under comparable conditions, followed by serial applications of test and control compositions are applied. Control treatments may be used comprising herbicide compositions lacking ectophosphatase inhibitors, thereby identifying the presence of absence of activity as a syngerist. Herbicidal activity is then measured by analysis of the effect of the composition on plant viability.
  • Commercial herbicide formulations are well known to those of skill in the art and will generally be used in assays. However, it will typically be preferred to dilute herbicidal compositions and/or administer reduced amounts of the compositions such that the relative herbicidal activity of a composition may be quantified. Reductions in the lethality of herbicidal compositions allows the identification of effectiveness between herbicidal compositions. Thus, in particular embodiments of the invention, test and control compositions are administered in rates and/or amounts of from about 90% to about 5% of the commercial application rate for a given herbicide.
  • Following application of herbicidal test compositions, herbicidal activity and effectiveness is measured. Through comparisons with applications of control compositions, the effectiveness of the compositions may be determined.
  • Tests may be carried out on whole plants as well as plant parts or cell. For example, plant cells in tissue culture may be screened for herbicidal activity. The preparation of plant tissue-cultures is well known to those of skill in the art.
  • (ii) In Vivo Assays
  • The present invention encompasses the use of various animal models. Here, the identity seen between human and mouse provides an excellent opportunity to examine the function of a potential therapeutic agent, for example, an antiinfective or chemotherapeutic administered in combination with an ectophosphatase inhibitor. In the case of chemotherapeutics, one can utilize cancer models in mice that will be highly predictive of cancers in humans and other mammals. These models may employ the orthotopic or systemic administration of tumor cells to mimic primary and/or metastatic cancers. Alternatively, one may induce cancers in animals by providing agents known to be responsible for certain events associated with malignant transformation and/or tumor progression. Similarly, numerous animal models are available for analysis of antinfectives, including insecticides, antibiotics and antifungal agents. In this manner, all that is commonly required is infection of the relevant animal with a target infective agent and analysis of therapeutic benefit relative to prior antiinfective compositions.
  • Treatment of animals with test compositions will involve the administration of the composition, in an appropriate form, to the animal. Administration will be by any route the could be utilized for clinical or non-clinical purposes, including but not limited to oral, nasal, buccal, rectal, vaginal or topical. Alternatively, administration may be by intratracheal instillation, bronchial instillation, intradermal, subcutaneous, intramuscular, intraperitoneal or intravenous injection. Specifically contemplated are systemic intravenous injection, regional administration via blood or lymph supply and intratumoral injection.
  • Determining the effectiveness of a compound in vivo may involve a variety of different criteria. Such criteria include, but are not limited to, survival, reduction of tumor burden or mass, arrest or slowing of tumor progression, elimination of tumors, inhibition or prevention of metastasis, increased activity level, improvement in immune effector function and improved food intake. Through comparisons of active agents alone and active agents in combination with ectophosphatase inhibitors, synergistic combinations may be readily confirmed.
  • (iii) Confirmatory In Vivo and Clinical Studies
  • It will be understood by those of skill in the art that therapeutic compositions should generally be tested in an in vivo setting prior to use in a human subject. Such pre-clinical testing in animals is routine in the art. To conduct such confirmatory tests, all that is required is an art-accepted animal model of the disease in question, such as an animal bearing a solid tumor or infective agent. Any animal may be used in such a context, such as, e.g., a mouse, rat, guinea pig, hamster, rabbit, dog, chimpanzee, or such like. Studies using small animals such as mice are widely accepted as being predictive of clinical efficacy in humans, and such animal models may thus find use in the context of the present invention as they are readily available and relatively inexpensive, at least in comparison to other experimental animals.
  • The manner of conducting an experimental animal test will be straightforward to those of ordinary skill in the art. All that is required to conduct such a test is to establish equivalent treatment groups, and to administer the test compounds to one group while various control studies are conducted in parallel on the equivalent animals in the remaining group or groups. One monitors the animals during the course of the study and, ultimately, one sacrifices the animals to analyze the effects of the treatment.
  • In the context of the treatment of tumors, it is contemplated that effective amounts of chemotherapeutic compositions will be those that generally result in at least about 10% of the cells within a tumor exhibiting cell death or apoptosis. Preferably, at least about 20%, about 30%, about 40%, or about 50%, of the cells at a particular tumor site will be killed. Most preferably, 100% of the cells at a tumor site will be killed.
  • The extent of cell death in a tumor is assessed relative to the maintenance of healthy tissues in all of the areas of the body. It will be preferable to use doses of chemotherapeutic compositions capable of inducing at least about 60%, about 70%, about 80%, about 85%, about 90%, about 95% up to and including 100% tumor necrosis, so long as the doses used do not result in significant side effects or other untoward reactions in the animal. All such determinations can be readily made and properly assessed by those of ordinary skill in the art. For example, attendants, scientists and physicians can utilize such data from experimental animals in the optimization of appropriate doses for human treatment. In subjects with advanced disease, a certain degree of side effects can be tolerated. However, patients in the early stages of disease can be treated with more moderate doses in order to obtain a significant therapeutic effect in the absence of side effects. The effects observed in such experimental animal studies should preferably be statistically significant over the control levels and should be reproducible from study to study.
  • Those of ordinary skill in the art will further understand that combinations and doses of the compositions provided by the invention that result in tumor-specific necrosis towards the lower end of the effective ranges may nonetheless still be useful in connection with the present invention. For example, in embodiments where a continued application of the active agents is contemplated, an initial dose that results in only about 10% necrosis will nonetheless be useful, particularly as it is often observed that this initial reduction “primes” the tumor to further destructive assault upon subsequent re-application of the therapy. In any event, even if upwards of about 40% or so tumor inhibition is not ultimately achieved, it will be understood that any induction, of thrombosis and necrosis is nonetheless useful in that it represents an advance over the state of the patients prior to treatments. Still further, it is contemplated that a dose which prevents or decreases the likelihood of either metastasis or de novo carcinogenesis would also be of therapeutic benefit to a patient receiving the treatment.
  • As discussed above in connection with the in vitro test system, it will naturally be understood that combinations of agents intended for use together should be tested and optimized together. The compositions of the invention can be straightforwardly analyzed in the combinations set forth herein. Analysis of the combined effects of such agents would be determined and assessed according to the guidelines set forth above.
  • (iv) In Vitro Assays
  • In one embodiment of the invention, screening of a composition provided by the invention is conducted in vitro to identify those compounds capable of synergizing therapeutic agents, including cytotoxic agents such as antibiotics, fungicides and chemotherapeutic agents, as well as other types of biologically-active agents. In the case of killing of tumor cells, cytotoxicity is generally exhibited by necrosis or apoptosis. Necrosis is a relatively common pathway triggered by external signals. During this process, the integrity of the cellular membrane and cellular compartments is lost. On the other hand, apoptosis, or programmed cell death, is a highly organized process of morphological events that is synchronized by the activation and deactivation of specific genes (Thompson et al., 1992; Wyllie, 1985). In the case of pesticides, the selective cytotoxic action against the infective agent, including an insect, bacterial or fungal pathogen, is typically analyzed.
  • An efficacious means for in vitro assaying of cytoxicity comprises the systematic exposure of a panel of cells to selected compositions. For example, in the case of cancer, many tumor cell lines are available for implementing assays, including human ovarian, leukemic, breast, prostate, melanoma and renal cancer cells.
  • In vitro determinations of the efficacy of a compound in killing tumor cells may be achieved, for example, by assays of the expression and induction of various genes involved in cell-cycle arrest (p21, p27; inhibitors of cyclin dependent kinases) and apoptosis (bcl-2, bcl-xL and bax). To carry out this assay, cells are treated with the test compound, lysed, the proteins isolated, and then resolved on SDS-PAGE gels and the gel-bound proteins transferred to nitrocellulose membranes. The membranes are first probed with the primary antibodies (e.g., antibodies to p21, p27, bax, bcl-2 and bcl-x1, etc.) and then detected with diluted horseradish peroxidase conjugated secondary antibodies, and the membrane exposed to ECL detection reagent followed by visualization on ECL-photographic film. Through analysis of the relative proportion of the proteins, estimates may be made regarding the percent of cells in a given stage, for example, the G0/G1 phase, S phase or G2/M phase.
  • VI. EXAMPLES
  • The following examples are included to demonstrate preferred embodiments of the invention. It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques discovered by the inventor to function well in the practice of the invention, and thus can be considered to constitute preferred modes for its practice. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.
  • Example 1 Inhibition of Antibiotic Resistant Bacteria with Ectophosphatase Inhibitors
  • A. Summary of Protocol and Results
  • The purpose of this study was to evaluate various ectophosphatase inhibitor compounds for any potentiating effect or resistance reversal with methicillin resistant Staphylococcus aureus (MRSA). Two strains of Staphylococcus aureus were obtained from the American Type Culture Collection (ATCC). Those obtained were a previously characterized methicillin resistant strain (# 43300) and a previously characterized methicillin sensitive strain (# 29213) to serve as a control. Strains were received as lyophilized pellets and were rehydrated according to the ATCC Product Information Sheet using Trypticase Soy Broth.
  • Mueller-Hinton agar plates were prepared containing 1 of 6 inhibitor compounds investigated. The compounds were dissolved in DMSO at concentrations of 20 mg/ml. 25 μl of this stock solution was added to 25 mls of media just prior to cooling to solidification to produce plates containing 20 μg/ml of inhibitor compound. Control plates containing 25 μl DMSO only were also prepared in the same fashion.
  • For each of the two strains, 5 isolated colonies were picked from overnight culture plates and used to inoculate a 0.85% NaCl solution. The turbidity of each culture was adjusted using 0.85% NaCl until the turbidity of each matched a 0.5 McFarland turbidity standard. Each strain was swabbed onto control plates. The MRSA strain was swabbed also onto the inhibitor plates. Plates were allowed to dry for 5 minutes. A disk containing 5 μg of methicillin (obtained for the purpose of susceptibility testing from Bioanalyse Co., Ltd.) was placed onto the surface of all plates. Plates were incubated at 37° C.
  • Plates were read after 24 hours. It was noticed at this time that one plate, containing inhibitor compound NGXT1914 (Formula XV), was clear—there was no bacterial growth at all. All other plates had confluent growth except at the zone of inhibition of the methicillin disk.
  • Protocols for the studies were according to NCCLS guidelines (M2-A7, M100-S11) for antimicrobial susceptibility testing. Methodology for the serum bactericidal test was according to (Tentative Guideline) NCCLS M21-T, 1992. Methods for determining bactericidal activity of antimicrobial agents was according to (Tentative Guideline) NCCLS M26-T.1992. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 3rd ed. NCCLS M7-A3.1993. Protocols for evaluating dehydrated Mueller-Hinton agar were according to NCCLS M6-A, 1996. Performance standards for antimicrobial susceptibility testing were according to NCCLS M100-S8, 1998. The screening test for Oxacillin-resistant Staphylococci was according to NCCLS M7-A4. Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals was according to (Approved Standard) NCCLS M31-A. Performance standards for antimicrobial susceptibility testing were according to NCCLS M100-S8.1998. Screening test for Oxacillin-resistant Staphylococci was according to NCCLS M7-A4 Susceptibility test panels.
  • B. Confirmation of Results
  • In order to ascertain whether the result with inhibitor NGXT1914 was artifactual, both MRSA and MSSA were tested on Mueller-Hinton agar plates containing varying concentrations of NGXT1914. First, plates were prepared as above with the following concentrations of inhibitor compound: 0 μg/ml (DMSO controls), 1 μg/ml, 5 μg/ml, 10 μg/ml, and 25 μg/ml. Inhibitor concentrations were prepared such that all plates contained 25 μl total DMSO. For each of the two strains, 5 isolated colonies were picked from fresh overnight culture plates and used to inoculate a 0.85% NaCl solution. The turbidity of each culture was adjusted using 0.85% NaCl until the turbidity of each matched a 0.5 McFarland turbidity standard. Both strains were each swabbed onto both control and inhibitor plates. Plates were allowed to dry for 5 minutes and were placed into the incubator. Plates were read after 24 hours (Dec. 7, 2001). The results were as follows:
    Concentration
    (μg/ml NGXT1914) Result
    25 μg/ml No growth at all for either strain
    10 μg/ml No growth at all for MRSA strain. Some
    small isolated colonies on the MSSA plate.
     5 μg/ml Only a few small colonies on the MRSA
    plate. Confluent growth on the MSSA
    plate.
     1 μg/ml Confluent growth on both plates.
    Controls Confluent growth on both plates.
  • C. Conclusions
  • Inhibitor NGXT 1914 inhibits growth of both resistant and sensitive Staph strains, however it is more effective against the methicillin resistant strain. This compound was tested with other cell types (mammalian cell lines, plants (Arabidopsis thaliana) yeast, Pseudomonas aeruginosa) and has not inhibited growth of any cell line or organism at the concentrations tested. Since NGXT1914 is an ectophosphatase inhibitor, it is possible that Staph, particularly the MRSA, is dependent on a phosphatase that is an ideal substrate for NGXT1914. The results obtained indicated that NGXT1914 was more effective against MRSA versus MSSA than previously identified compounds.
  • Example 2 Inhibition of Chemotherapy-Resistant Tumor Cells with an Ectophosphatase Inhibitor
  • In order to determine the effect of ectophosphatase inhibitors on tumor cells resistant to a chemotherapeutic agent, 2 breast cancer tumor cell lines were tested, a vinblastine resistant line (SW-13Vb003) and its vinblastine sensitive parent line, SW-13. A standard 4 day incubation at 37° C. and 5% CO2 was used. IC50 tests (NTT) were done using standard methodology in 96 well plate format with inhibitor concentrations ranging from 0-90 μg/ml (DMEM media). Results showed that 3 of the inhibitor compounds tested, NGXT194 (Formula VI), NGXT196 (Formula VIII), and NGXT1915 (Formula X), produced lower IC50 values with the resistant cell line than with the sensitive line. For NGXT194, SW-13 was sensitive at 20 μg/ml, whereas the vinblastine resistant line SW-13Vb003 was sensitive at 10 μg/ml. For NGXT196, SW-13 was sensitive at 30 μg/ml, whereas the vinblastine resistant line SW-13Vb003 was sensitive at 10 μg/ml. For NGXT1915, SW-13 was sensitive at 50 μg/ml, whereas the vinblastine resistant line SW-13Vb003 was sensitive at 20 μg/ml.
  • Based on the inventors previous findings concerning the role of ectophosphatases in drug resistance, it seems likely that many resistant cells have upregulated phosphatases and that inhibiting a phosphatase critical to maintaining these cells could result in cell death. One hypothesis is that once these phosphatase enzymes are upregulated or are used in drug resistance their function becomes one that is vital to the cell. Since this phenomenon has been seen now in a bacterial resistance model it might be expected that the ectophosphatase inhibiting compounds could preferentially kill other types of resistant cells or act as biocides to certain cells.
  • Example 3 Over-Expression of Ectophosphatase does not Increase the Cellular Uptake of Adenosine
  • A. Materials and Methods
  • Transgenic Plant Construction: psNTP9 (Pisum Sativum apyrase, GenBank accession #Z32743) was subcloned as a Sall to Xbal fragment into pKYLX71 (Schardl et al, 1987, supra.). This plasmid was transformed into A. tumefaciens GV3101 [pMP90] pKYLX71 (Koncz and Shell, 1986), which was used to infect root call from Ws ecotype Arabidopsis thaliana under kanamycin selection (Valvekens et al., 1992). Four individual lines, obtained from separate calli, were propagated to the third generation (T3).
  • Subcellular Apyrase Distribution in Pea: Etiolated pea plumules served as the tissue source for nuclei and cytoplasm isolation as described by Chen and Roux (Plant Physiol. 81:609-612 (1986)). Plasma membrane was prepared from 30 g of pea root tissue (Zhu Mei Jun and Chen Jia; 1995, Acta Botanica Sinica 37:942-949). Western analysis was performed on 15-30 pg of protein from cytoplasm, plasma membrane and nuclei using a polyclonal anti-apyrase antibody raised against the purified pea protein (Tong et al., 1993). To determine the orientation of the pea apyrase in the pea plasma membrane, outside-out vesicles were prepared and the accessibility of the enzyme was determined by selective trypsin proteolysis, or membrane shaving, followed by activity assays and western blotting.
  • Phosphate uptake experiments and growth assays: In all experiments the growth media did not contain sugar, and plants were grown in sterile culture at 22° C. under 150-200 pE of continuous light. Unless otherwise noted, a standard 0.8% agar medium (Becton Dickenson, Cockeysville, Md.) containing 100 μM phosphate was used for uptake assays (Somerville et al., 1982). Plants used for the phosphate uptake experiments were grown singly in 1 ml of the standard agar medium for 15 days prior to the experiment. On the day of the experiment, 10 μCi32P was applied to the side of the culture dish and allowed to diffuse through the agar. The lids of 95 mm×15 mm tissue' culture dishes (Fisher, Pittsburgh, Pa.) were removed to facilitate transpiration.
  • After 18 hours, the plants were removed from the medium. The aerial portions of the plant not in contact with the agar were weighed and counted by liquid scintillation. For each plant the entire root system was carefully pulled from the agar and washed in ice cold water prior to scintillation counting. To measure the transport of the products of ATP hydrolysis by the transgenic plants overexpressing apyrase and by wild-type plants, [2,83H]ATP, [α32P]ATP, and [γ32P]ATP (Amersham) were fed to 15-day-old plants in separate treatments. All treatments were analyzed for significance in a T-test (n>46 for all groups, *P<0.05, error bars=s.e.m.).
  • B. Results
  • Detection of the pea apyrase in nuclei and in purified plasma membrane: By immunoblot assay, the pea apyrase was found to be associated with nuclei and with purified plasma membranes but not with the cytoplasm (FIG. 1A). The contents of the lanes in FIG. 1A are as follows: Lane 1, cytoplasm; Lane 2, purified plasma membrane; Lane 3, purified nuclei; and Lane 4, pre-immune control of nuclei. Protease treatment destroyed both apyrase activity and antigenicity in outside-out plasma membrane vesicles. After trypsin treatment, the exterior face of the vesicle showed 30% of the ectophosphatase activity of the untreated sample. Endo-phosphatase activities were retained after trypsin treatment, indicating that the digest occurred exclusively on the exterior face of the membrane. These data indicated that the ectoapyrase was in fact being expressed in the extracellular matrix (ECM).
  • Enhanced Growth of Plants Over-Expressing Apyrase: Three of the four transgenic plant lines constitutively expressed psNTP9 under the control of the cauliflower mosaic virus 35S promoter and over an 18 hour period showed two to five times as much phosphate accumulation in shoots as wild type (FIG. 1B); Top, the total phosphate accumulated in the shoots of three independent transformants in an 18 hour 32 p uptake assay at 2 mM phosphate; Bottom, a corresponding immunoblot performed on equal amounts of protein isolated from the ECM of three week-old wild-type Arabidopsis thaliana and the psNTP9 transgenics. Apyrase expressing plants also showed four times as much phosphatase activity in the extracellular matrix as the wild-type (FIG. 1 C). (Note, OE 1 in the FIG. stands for over-expression 1 transgenic line).
  • Transgenic plants preferentially transport the gamma phosphate of ATP: In order to address whether over-expression of ectoapyrase was stimulating the adenosine salvage pathway, the intracellular uptake of adenosine was measured both in the presence and absence of the overexpression of apyrase. The inability of apyrase to translocate either extracellular AMP or adenosine was demonstrated by the low level of radiolabel accumulated in the transgenic plants fed [2,83H]ATP and [a32P]ATP (FIG. 2). The complete dephosphorylation of [2,83H]ATP would result in a radiolabelled adenosine molecule while the complete dephosphorylation of [a32P]ATP would result in a non-labeled adenosine label. FIG. 2A illustrates that plants overexpressing apyrase did not translocate radiolabelled adenosine (or byproducts of the dephosphorylation of [2,83H]ATP) any more efficiently than plants not overexpressing apyrase (wild-type plants). FIG. 2B illustrates that plants overexpressing apyrase did not translocate AMP (or the byproducts of the dephosphorylated [a32P]ATP) any more efficiently than wildtype plants. In comparison, feeding experiments where the y phosphate was labeled, the transgenics accumulated three times the amount of labeled phosphate as the wild-type (FIG. 2C). These data show that the over-expression of apyrase does not induce an increase in the uptake of adenosine and therefore its over-expression does not act to stimulate the adenosine salvage pathway.
  • Example 4 EctoPhosphatase is Involved in Drug Resistance in Yeast and Plants
  • A. Materials and Methods
  • Expression of AtPGP-1 in yeast: The AtPGP-1 cDNA (Arabidopsis thaliana MDR gene, accession #X61370) was subcloned into pVT101 downstream of the ADH promoter to create the AtPGP-1/pVT101 construct. AtPGP-1/pVT101 and pVT101 were transformed into Saccharomyces cerevisiae INVSCI (genotype: MATa, his3-Δ1, leu2, trpl-289, ura3-52) and YMR4 (genotype: MATαhis3-11,15, leu2-3, 112ura3Δ5, can Res pho5, 3::ura3A1) by a PEG lithium acetate procedure (Eble, 1992) and selected on uracil dropout medium.
  • Yeast Growth: Yeast were grown at 30° C. under conditions of constant selection for uracil auxotrophy. YNB (Bio101, Vista, Calif.) supplemented with CSM (uracil dropout) and 2% glucose was used to grow strains having pVT101 constructs. Cycloheximide (Sigma Chemical, St. Louis, Mo.) was added to liquid media or spread on solid media to achieve a final concentration of 500 ng/ml. Nigencm (Sigma Chemical, St. Louis, Mo.) was added to liquid media or spread on solid media to achieve a final concentration of 25 μg/ml. Yeast strains used in cycloheximide selection assays were always propagated in the presence of the cycloheximide on plates and then streaked onto new plates containing drug or no drug, such that induced resistance existed in each strain at the time of the start of the assay. For selection assays on plates, single colonies were streaked; for selection in liquid media 0.01 ml of saturated culture was added to fresh media containing the drug. The plates shown in figures were grown for 3-5 days before photographs were taken. Yeast selection assays in liquid media were quantitated by turbidity as measured by absorbance at OD600.
  • Expression of apyrase and AtPGP-1 in plants: The expression of apyrase in plants is as described above in Example 3. Similar methods were employed to express AtPGP-1 in Arabidopsis thaliana plants with the following modifications. The AtPGP-1 coding region was subcloned into a pBIN vector lacking the GUS gene as described in Sidler et al. (1998). This plasmid was then transformed into A. tumefaciens as described above, which was used to infect root calli to produce transgenic plants expressing AtPGP-1.
  • Plant growth: Arabidopsis thaliana seeds were sown in a solid germination media containing MS salt, 2% sucrose, 0.8% agar, and vitamins (Valvekens et al., 1992). For selection assays, cycloheximide was spread on the media to achieve a final concentration of 250 ng/ml. Plant growth was measured by germination percentage after 6-30 days.
  • B. Results
  • Effect of over-expression of AtPGP-1 in yeast: When a yeast mutant, YNIR4, which is deficient in two major extracellular phosphatases and tends to accumulate ATP extracellularly, was grown in a potent cellular toxin, cycloheximide, it did not grow whereas a wild-type yeast strain, INVSCI, did grow in the presence of cycloheximide (FIG. 3A). Surprisingly, expression of the plant multidrug resistance (MDR) gene, AtPGP-1, enabled the yeast mutant to grow in the toxin (FIG. 3B and FIG. 5A). The presence of AtPGP-1 in the wild-type yeast did not have any effect when grown in the presence of cycloheximide (FIG. 3B). The same result was obtained when the yeast strains were cultured in nigericin (FIG. 3C, 3D, FIG. 5B, 5C). In FIGS. 3C and 3D, starting from the top of the dish clockwise, the cells are as follows: INVSCI (wild-type) overexpressing AtPGP-1, YNM4 containing the vector alone, YMR4 overexpressing AtPGP-1, and INVSCI containing the vector alone. When grown without drug, all the cells grow (FIG. 3C). However, when grown in drug, only the YMR4 containing vector alone shows reduced growth. The survival of the AtPGP-1 transformed strains was due to the ability of the NIDR1 channel to efflux the toxin, hence lowering the actual cellular concentration of the poison cycloheximide. The sensitivity of the untransformed mutant to the drug is likely due to a loss of the ATP gradient below a point at which endogenous transporters, similar to AtPGP-1 can function.
  • Effect of over-expression of AtPGP-1 in plants: The over-expression of AtPGP-1 was able to confer resistance to cycloheximide in plants (FIGS. 4A and 6) and to the cytokinin, N6-(2isopentenyl)adenine (21P) (FIG. 4B). These results had not been observed previously and in fact, the prior art actually teaches away from this finding suggesting that over-expression of plant AtPGP-1 is not involved in drug resistance (Sidler. et al., 1998). Therefore, this result was particularly unexpected in plants. Additionally, since Arabidopsis plants overexpressing AtPGP-1 are able to grow in both cycloheximide and cytokinin, this suggests that the conference of drug resistance by AtPGP-1 is likely to be seen with other chemicals as well and is not an isolated phenomenon.
  • Effect of over-expression of apyrase on drug resistance in plants: Another unexpected result was obtained when the plant apyrase gene was over-expressed in plants. Over-expression of apyrase in plants resulted in the conference of resistance to cycloheximide (FIGS. 4A and 6). The same result was obtained when the plants were grown in the presence of a cytokinin, N6-(2isopentenyl)adenine (FIG. 4B). In fact, over-expression of apyrase is surprisingly able to raise the germination rate above the level obtained by the over-expression of the MDR gene AtPGP-1 (FIGS. 4A, 4B and 6). Just as under-expression of phosphatase activity in a yeast mutant lacking two potent extracellular phosphatases diminished its resistance to cycloheximide (FIG. 3A), over-expression of a powerful extracellular ATP phosphatase in plants bolstered resistance. The fact that higher resistance was found in plants genetically manipulated only with respect to phosphatase over-expression and not MDR1, indicates that there likely exists other ATP-symporters used in detoxification in addition to MDR1. Minimally, the stronger ATP gradient set up by apyrase in the transgenic plants affects the kinetics of the wild-type MDRI.
  • Example 5 ATP Efflux in Yeast and Plants Overexpressing AtPGP-1
  • A. Materials and Methods
  • ATP collection: Yeast cells used in the luciferase assays were grown for two days and then transferred to Lsh media at the time of the assay. From this time forward, the cells were kept at room temperature on a rotator. Every hour a 1 ml aliquot was taken, the cells in the aliquot were counted on a hemocytometer, a methylene blue viability assay was performed (Boyum and Guidotti, 1997), the cells were centrifuged, and the supernatant was stored in liquid nitrogen until all the aliquots were collected. For luciferase assays involving plants, Arabidopsis thaliana plants were grown in sterile culture at 22° C. under 150-200 pE of continuous light for at least 15 days. Foliar ATP was collected by placing a single 30 pl drop of luciferase buffer (Analytical Luminescence Laboratory, Cockeysville, Md.) on a leaf and, without making direct physical contact with the plant, the droplet was immediately collected and snap frozen. For each leaf, the area was approximated as an integrated area of a 2-D image of the leaf using NIH 1.52 software (Shareware, NIH).
  • Luminometry: Samples were reconstituted to a 100 pl final volume in Firelight™ buffer (Analytical Luminescence Laboratory, Cockeysville, Md.). After the buffer was added, all samples were kept on ice. ATP standards were reconstituted in 100 μl of Firelight™ buffer and the standards and sample were loaded into a 96-well plate and read on an automated Dynex Technologies Model MLX luminometer (Dynex Technologies, Chantilly, Va.). Samples were processed with the addition of 50 μl of Firelight™ enzyme (Analytical Luminescence Laboratory, Cockeysville, Md.) followed by a reading delay of 1.0 second and an integration time of 10 seconds. Output was taken as an average for the integration time and then averaged for multiple samples. The sample handling time was less than 2 hours.
  • Pulse Chase experiments: Yeast were grown to saturation in liquid medium, as described above, centrifuged, and resuspended in fresh medium containing 1 μCi/ml 3H-adenosine (Amersham, Arlington Heights, Ill.). The cells were rotated at room temperature for 20 minutes to allow adenosine uptake. After 20 minutes the cells were centrifuged. The pellet was washed twice in ice cold medium, resuspended in culture medium at room temperature, divided equally between five types (five per cell line), and placed on a rotator. Every ten minutes a separate tube from each cell line was centrifuged and the pellet and supernatant were placed in separate scintillation vials. The efflux activity was expressed as the ratio of counts in the supernatant to counts in the pellet.
  • B. Results
  • The ATP effluxed by the plant MDR1, AtPGP-1, over-expressed in yeast: In wild-type cells there is a steady-state level of ATP in the extracellular fluid, which is to say that the ATP outside the cells is rapidly degraded by phosphatases and does not accumulate over time (FIG. 7). However, the expression of the AtPGP-1 doubled this steady-state level (FIG. 8). If the yeast mutant, YMR4, which is deficient in extracellular phosphatase activity, is analyzed, there was a noticeable accumulation of ATP in the extracellular fluid compared to a control mutant transformed with empty plasmid pVT101 (FIG. 9). In addition to ATP measurements based on luminometry performed on a kinetic time-scale of hours, an earlier differential ATP efflux in MDRI expressing cells by pulse chase experiments was demonstrated (FIG. 10). Furthermore, Arabidopsis thaliana plants from two independently transformed lines, that constitutively express the AtPGP-1 protein, showed a significant accumulation of ATP on their leaf surfaces (FIG. 11). Taken together, these data demonstrate the absolute ability of plant MDRI, AtPGP1, to transport ATP from inside the cell to the outside. Moreover, these data show that ATP efflux channels and phosphatases both have roles in the steady-state level of ATP outside of the cell. This is the first demonstration of the importance of extracellular ATP steady-state levels, and the importance of an ATP gradient across biological membranes in the modulation of drug resistance.
  • Example 6 A Two-Component System is Found in Arabidopsis Plants
  • A. Materials and Methods
  • Plant Growth: Arabidopsis seeds were sown in a solid germination media containing MS salts (Sigma Chemical, St. Louis, Mo.), 2% sucrose, 0.8% agar, and vitamins (Valvekens et al., 1992). For selection assays, one of the following, or a combination of both, was added to media (cooled to less than 50° C. before adding) immediately prior to pouring into plates: cycloheximide at a final concentration of 500 ng/ml; α,β-methyleneadenosine 5′-diphosphate at a final concentration of 1 mM. Plant growth was measured by germination percentage after 10-20 days.
  • All other materials and methods were discussed above in Example 4.
  • B. Results
  • Effects of phosphatase inhibitor on plants overexpressing AtPGP-1: FIG. 12 shows that when wild-type and AtPGP-1 overexpressing (MDR OE) Arabidopsis thaliana plants were either treated with nothing (lane 1), cycloheximide (lane 2), a,(3-methyleneadenosine 5′-diphosphate (phosphatase inhibitor) (lane 3), or cycloheximide and phosphatase inhibitor (lane 4), both the wild-type and the AtPGP-1 overexpressing plants were affected similarly by the presence of phosphatase inhibitor. While the AtPGP-1 overexpressing plants grew significantly better in the presence of cycloheximide alone with a 50% germination rate for the AtPGP-1 overexpressing plants and a 2% germination rate for the wild-type plants, similar germination rates were seen for both the AtPGP-1 overexpressing and wild-type plants in the presence of either phosphatase inhibitor alone (83% and 90% germination respectively) or cycloheximide plus phosphatase inhibitor (no germination at all). The addition of phosphatase inhibitor surprisingly destroys the ability of the AtPGP-expressing plants to grow in the presence of cycloheximide. These data suggest that phosphatases are involved in the conference of drug resistance in plants and that there is a two-component system similar to that demonstrated in yeast in Example 4 and 5 above in which an MDR-like protein and an ATP-gradient-maintaining ectophosphatase are important in modulating drug resistance.
  • Example 7 The ATP Gradient Directly Effects Drug Resistance in Cells
  • A. Materials and Methods
  • Cell lines: Cell lines were the same as those described above in Example 4 and 5. YMR4 MDRI is the phosphatase mutant yeast strain overexpressing AtPGP-1; YMR4 pVT011 contains vector alone; INVSC MDRI is the wild-type yeast strain overexpressing AtPGP-1; and INVSC pVT101 contains vector alone.
  • Selection in drug: To create drug resistant yeast strains, all four cell lines were grown up in the presence of 500 ng/ml of cycloheximide, and transferred to other cycloheximide containing plates after a period of four to six days. This transfer of cell lines and subculturing continued such that the yeast cells grew in the presence of cycloheximide for a period of at least a month. Cells cultured in media alone: To create cell lines that had not been preselected for their ability to grow in drug, yeast strains were grown on plates containing YNB (Bio101, Vista, Calif.) without uracil (-URA) to maintain the presence of the vector (which supplies URA) without any drugs added.
  • Growth of cells in suspension for ATP and drug selection experiments: Cells were transferred into 5 ml YNB-URA liquid media for turbidity measurements. All cell lines (both non-drug selected and drug-selected) were grown in media with the addition of either nothing, 500 ng/ml cycloheximide, 100 mM ATP, or 500 ng/ml cycloheximide and 100 mM ATP. Turbidity readings were taken after 48 hours.
  • Growth of cell lines in suspension for salvage pathway experiments: All cell lines were grown in liquid media either containing drug (for the drug selected lines) or not containing drug (for the non-drug selected lines). When the cultures reached a turbidity of 1.00 as measured at a wavelength of 600 in a spectrophotometer (OD600=1.00), 10 μl of each culture was then removed and placed in either media with nothing added, 3 mM potassium phosphate; 3 mM adenosine; 9 mM potassium phosphate and 3 mM adenosine (for controls); potassium phosphate and cycloheximide; adenosine and cycloheximide; adenosine, cycloheximide, and potassium phosphate. Cell cultures were further grown for 72 hours, and their turbidity was determined by OD600 readings on a spectrophotometer.
  • Growth of cell lines for nigericin experiments: Drug selected lines were removed from cycloheximide containing plates and placed in 5 ml liquid media containing 5 ng/ml cycloheximide. Cell cultures were allowed to grow until they reached an OD600 reading of 1.00, and then 10 μl from each culture was removed and transferred to culture tubes containing 5 ml of liquid media and 25 pg/ml nigericin. OD600 readings were recorded daily for a period of up to 72 hours to determine growth.
  • B. Results
  • An ATP gradient is critical in MDR: The importance of the ATP gradient in MDR in yeast cells was demonstrated by showing that the growth of cells which were previously grown in drug and had developed resistance to the drug, were not able to grow in high levels of ATP unless they were overexpressing AtPGP-1 (FIG. 13). Cells which had not been previously selected in drug were able to grow in the presence of high levels of ATP (FIG. 13). These data emphasize that the loss of an ATP gradient is previously resistant cell lines abolishes resistance. This result is new to the understanding of MDR and has led to vast insight into the understanding of the mechanism by which MDR-ABC transporters confer resistance to cells and to methods to modulate such resistance. Moreover, when cells were grown in high levels of ATP and drug (cycloheximide), even the cell lines which had previously showed resistance to drug were unable to grow in the presence of drug and ATP. These data indicate that when the ATP gradient across biological membranes is destroyed (by the presence of high extracellular levels of ATP), efflux a of drugs cannot be achieved and therefore, drug resistance is abolished. In summary, the multidrug resistance channel is not functional without an ATP gradient.
  • The drug resistance is not due to an adenosine salvage pathway: In order to address whether the involvement of a nucleotide salvage pathway was responsible for the results of the present invention, yeast cells were cultured in the presence of extracellular adenosine and extracellular phosphate. The acid phosphatase yeast mutant, YMR4, was selected because its decreased ectophosphatase activity makes it an ideal candidate for studying the effect of extracellular nucleotides on growth. If an adenosine salvage pathway were involved, then the presence of extracellular adenosine or possibly phosphate should help cells recoup the intracellular ATP losses due to ATP/drug efflux and should help cells grow in the presence of drug whether or not the cells were overexpressing AtPGP-1. In contrast, however, the addition of adenosine or phosphate to the media did not enhance resistance to the cells (FIG. 14). In fact, cells overexpressing AtPGP-1 grew best in drug alone, with the addition of adenosine and/or phosphate being slightly inhibitory. Furthermore, cells which did not express AtPGP-1 were unable to grow in drug regardless of the presence of adenosine and/or phosphate. These data suggest that an adenosine salvage pathway is not the principal mechanism at work in the present invention.
  • Example 8 High Throughput Screen for Isolating Apyrase Inhibitors
  • A. Materials and Methods
  • Small Molecule Library: A small molecule library (DIVERSet format F), which was specifically constructed to maximize structural diversity in a relatively small library (9600 compounds), was obtained from ChemBridge Corporation (San Diego, Calif.). The small molecules (supplied in 0.1 mg dehydrated aliquots) were dissolved in DMSO, transferred to a 96 well plate, and tested for their ability to inhibit apyrase activity.
  • The assay: A stringent screen to test the ability of small molecules to disrupt the ATPase activity of the apyrase enzyme was developed based on phosphate-mobylate complexation. The assay was a modification of a phospholipase assay developed by Hergenrother et al. (1997): Under normal conditions, the apyrase enzyme liberates phosphate from ATP present in the reaction. The liberated phosphate quickly forms a complex upon addition of a small amount of acidified molybdate and ascorbate allowing for the production of a very dark blue color (the less phosphate liberated, the less blue color). Control reactions were performed with heat inactivated apyrase enzyme. Color intensity was detected on an Alpha Imager 2000 with AlphaEase™ software (Alpha Innotech, San Leandro, Calif.). Color changes were also evident by the naked eye. A Biomek 2000 robot (Beckman, Fullerton, Calif.) was used for screening the 9600 samples.
  • To each well of the 96 well plates containing a small molecule from the library, 100 pI of reaction buffer (60 mM HEPES, 3 MM MgCl2, 3 mM CaCl2, 3 mM ATP pH 7.0) was added. The apyrase (potato apyrase grade VI, Sigma Chemical, St. Louis, Mo.) enzyme (0.1 units) was added in a 5 pI volume and the reaction was allowed to proceed at room temperature for 60 minutes.
  • Three buffers were used to visualize activity: Buffer A: 2% Ammonium molybdate in water Buffer B: 1 I% Ascorbic acid in 37.5% aqueous TCA. Buffer C: 2% trisodium citrate, 2% acetic acid.
  • Immediately before developing the assay, buffers A and B were mixed in a 1:1 5 ratio. 50 pl of A:B was added to each well. The 96 well plate was then vibrated on a table surface to mix the solution. The deep blue color developed after approximately 2 minutes. After 2 minutes, 50 p.l of buffer C was added to each well and the blue color became darker, increasing the sensitivity of the assay. The color intensified for up to one hour with no accompanying color change in the control wells containing heat inactivated apyrase enzyme. The color intensity for a single plate was measured on an Alpha Imager 2000 with AlphaEase™ software (Alpha Innotech, San Leandro, Calif.).
  • B. Results:
  • Nineteen positives were identified from the 9600 compound DIVERSet library. Dose response assays revealed that fourteen showed weak inhibition, two showed medium inhibition (Formulas N and V), and three showed relatively strong inhibition (Formulas I, II and III).
  • All of the compositions and methods disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure. While the compositions and methods of this invention have been described in terms of preferred embodiments, it will be apparent to those of skill in the art that variations may be applied to the compositions and methods and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the invention. More specifically, it will be apparent that certain agents which are both chemically and physiologically related may be substituted for the agents described herein while the same or similar results would be achieved. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims.
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Claims (29)

1. A cytotoxic composition comprising an ectophosphatase inhibitor and a cytotoxic agent set forth in Table 1.
2. The cytotoxic composition of claim 1, wherein the cytotoxic agent is selectively cytotoxic.
3. The cytotoxic composition of claim 1, further defined as a herbicidal composition and wherein the cytotoxic agent is a herbicide.
4. The cytotoxic composition of claim 1, further defined as an insecticidal composition and wherein the cytotoxic agent is an insecticide.
5. The cytotoxic composition of claim 1, further defined as a fungicidal composition and wherein the cytotoxic agent is a fungicide.
6. The cytotoxic composition of claim 1, further defined as an antibiotic composition and wherein the cytotoxic agent is an antibiotic.
7. The antibiotic composition of claim 6, wherein the antibiotic is from a class selected from the group consisting of Beta-lactam, Semisynthetic penicillin, Clavulanic Acid, Monobactams, Carboxypenems, Aminoglycosides, Glycopeptides, Lincomycins, Macrolides, Polyenes, Rifamycins, Tetracyclines, Semisynthetic, tetracycline and Chloramphenicol.
8. The cytotoxic composition of claim 1, wherein the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulae I-XX.
9. A plant growth regulator composition comprising an ectophosphatase inhibitor and a plant growth regulator agent set forth in Table 1.
10. The plant growth regulator composition of claim 9, wherein the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulae I-XX.
11. A chemotherapeutic composition comprising an ectophosphatase inhibitory compound and a chemotherapeutic agent.
12. The chemotherapeutic composition of claim 11, wherein the chemotherapeutic agent is a chemotherapeutic agent set forth in Table 3.
13. The chemotherapeutic composition of claim 11, wherein the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulae I-XX.
14. A method of killing or inhibiting the growth of a plant, comprising contacting said plant with an effective amount of the composition of claim 3.
15. The method of claim 14, wherein said plant is a monocotyledonous plant.
16. The method of claim 14, wherein the plant is a dicotyledonous plant.
17. A method of killing or inhibiting the growth of a tumor cell, comprising contacting said tumor cell with an effective amount of the composition of claim 11.
18. The method of claim 17, wherein contacting comprises administering said composition of claim 11 to a patient in need thereof, wherein the patient comprises the tumor cell.
19. A method of killing or inhibiting the growth of an insect, comprising contacting said insect with the composition of claim 4.
20. A method of killing or inhibiting the growth of a fungal cell, comprising contacting said cell with the composition of claim 5.
21. A method of killing or inhibiting the growth of a bacterial cell, comprising contacting said cell with the composition of claim 6.
22. A method of increasing the effectiveness of a cytotoxic agent, comprising admixing said cytotoxic agent with an ectophosphatase inhibitor, wherein the cytotoxic agent is selected from the group set forth in Table 1.
23. The method of claim 22, wherein the cytotoxic agent is further defined as a herbicide.
24. The method of claim 22, wherein the cytotoxic agent is further defined as an insecticide, fungicide, or antibiotic.
25-26. (canceled)
27. The method of claim 24, wherein the antibiotic is from a class selected from the group consisting of Beta-lactam, Semisynthetic penicillin, Clavulanic Acid, Monobactams, Carboxypenems, Aminoglycosides, Glycopeptides, Lincomycins, Macrolides, Polyenes, Rifamycins, Tetracyclines, Semisynthetic, tetracycline and Chloramphenicol.
28. The method of claim 22, wherein the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulae I-XX.
29. A method of increasing the effectiveness of a chemotherapeutic agent, comprising admixing said chemotherapeutic agent with an ectophosphatase inhibitor, wherein the chemotherapeutic agent is selected from the group set forth in Table 3.
30. The method of claim 29, wherein the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulae I-XX.
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