US20050016892A1 - Vials-blinding solution (container and its use in packaging, for example packaging for remedies) - Google Patents

Vials-blinding solution (container and its use in packaging, for example packaging for remedies) Download PDF

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Publication number
US20050016892A1
US20050016892A1 US10/736,957 US73695703A US2005016892A1 US 20050016892 A1 US20050016892 A1 US 20050016892A1 US 73695703 A US73695703 A US 73695703A US 2005016892 A1 US2005016892 A1 US 2005016892A1
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US
United States
Prior art keywords
container
covering
container wall
wall
packaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/736,957
Inventor
Alain Duerr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisher Clinical Services GmbH
Original Assignee
Fisher Clinical Services GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisher Clinical Services GmbH filed Critical Fisher Clinical Services GmbH
Assigned to FISHER CLINICAL SERVICES AG reassignment FISHER CLINICAL SERVICES AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DUERR, ALAIN
Publication of US20050016892A1 publication Critical patent/US20050016892A1/en
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D23/00—Details of bottles or jars not otherwise provided for
    • B65D23/08—Coverings or external coatings
    • B65D23/0842—Sheets or tubes applied around the bottle with or without subsequent folding operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D23/00—Details of bottles or jars not otherwise provided for
    • B65D23/08—Coverings or external coatings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1328—Shrinkable or shrunk [e.g., due to heat, solvent, volatile agent, restraint removal, etc.]
    • Y10T428/1331—Single layer [continuous layer]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]

Definitions

  • the invention relates to a container according to the precharacterizing clause of claim 1 and packaging, for example packaging for remedies, comprising a plurality of such containers according to the precharacterizing clause of Claim 10 .
  • Containers and packagings of the type according to the invention are used, for example, in clinical trials of drugs or remedies.
  • clinical trials a large number of test subjects take the drugs to be tested, orally, parenterally or topically, over a predetermined time span and according to a special administration plan, and the reactions of the test subjects and the effects of the drugs are recorded and statistically evaluated.
  • FIG. 1 shows a container drawn partly in section and partly as a view
  • FIG. 2 shows a view of a covering formed from plastic, in the unfolded state
  • FIG. 2 a shows a view in the direction of arrow IIa of FIG. 2
  • FIG. 3 shows a view of the container with mounted plastic covering
  • FIG. 3 a shows a view in the direction of arrow IIIa of FIG. 3 ,
  • FIG. 4 shows, by way of example, five containers according to FIG. 1 , intended for medical packaging, and
  • FIG. 5 shows the five containers of FIG. 4 in the dosage form as used in packaging of the type according to the invention.
  • the container shown in FIGS. 1 and 3 to 5 and denoted as a whole by 1 also referred to below as a vial, has a transparent, for example glass-clear, glass or plastic wall 2 with a base 3 and a plug 5 which fits detachably or nondetachably in the bottleneck 4 and has an associated lid 6 .
  • the lid 6 is formed and dimensioned in such a way that, in the fastened state, it projects over the edge of the filling orifice, or over the bottleneck 4 in the examples present here.
  • the vial 1 it is intended to surround the vial 1 by a covering 8 arranged on the outside of the container wall 2 and making the pharmaceutical formulation 7 contained in the container appear opaque through the transparent container wall 2 , so that the appearance of the pharmaceutical formulation, for example whether it is a coloured, pulverulent, lyophilized or granular formulation, is visually undetectable for a user.
  • the covering 8 consists of a premoulded plastic jacket which fits tightly against the container wall 2 and is formed, for example, from two parts 8 a and 8 b intended for enclosing the container 1 and connected to one another along a generating line.
  • the two parts 8 a and 8 b each form a neck section 8 c and 8 d fitting the bottleneck 4 , and the covering 8 is, for example, translucent and coloured, milky or cloudy.
  • the covering 8 consists, for example, of pure plastic, such as, for example, of polyethylene or polyvinyl chloride or of another plastic serving the purpose according to the invention, or of a combination of materials comprising a plastic film with, for example, aluminium or paper, or of a laminated foil.
  • the covering 8 can be arranged detachably or nondetachably on the container wall 2 . If the covering 8 is to be arranged detachably on the container wall 2 , it is closed, for example, by means of an adhesive strip preferably enclosing it completely or by means of an adhesive. If, however, the covering 8 is to be fastened nondetachably on the container wall 2 , the covering 8 is, for example, adhesively bonded to the wall 2 over the whole surface or part of the surface.
  • At least one outer note or label which can be wrapped around the covering 8 and has information relating to content, administration times and the like can additionally be provided on the covering 8 .
  • a packaging according to the invention intended for remedies and comprising a plurality of containers 1 ( 1 . 1 to 1 . 5 ) each containing a pharmaceutical formulation 7 ( 7 . 1 to 7 . 5 ), is distinguished by the fact that all containers 1 . 1 to 1 . 5 are provided with a standard covering 8 of the type described above so that the appearances of the pharmaceutical formulations 7 . 1 to 7 . 5 cannot be visually distinguished from one another by a user, which is shown graphically in FIG. 5 .
  • the coverings 8 may all be translucent and coloured, milky or cloudy.
  • a substantial advantage of a packaging according to FIG. 5 for remedies thus consists in the fact that the different preparations provided inside the packaging have a standard appearance to the user or to the test subject, regardless of the type of their pharmaceutical formulations.
  • FIGS. 1 to 5 represents only a selection of a plurality of possible embodiments of the invention and can be modified in various respects.
  • coverings 8 which are coloured or black or white and nontransparent or translucent in such a way that the appearance of the container wall 2 itself, for example its colour or its initial labelling, is undetectable are proposed, for example, for containers having a nontransparent container wall.
  • nontransparent coverings 8 for example premoulded coloured, black or white plastic films, can also be used for containers having a transparent container wall.
  • the containers according to the invention may also be in the form of an ampoule or a syringe instead of a vial.
  • the container can of course have any desired shape, depending on the respective application, it being possible for said shape to vary greatly according to field of use, for example in chemistry, medicine or the food industry, as well as in its dimensions.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Packages (AREA)

Abstract

The invention relates to a container (1.1-1.5) and a packaging, for example packaging for remedies, comprising a plurality of such containers. Containers and packaging of the type according to the invention are used, for example, in clinical trials of drugs or remedies. According to the invention, it is intended to provide the container or containers with a covering (8) which is arranged on the outside of the container wall and either changes the appearance of the container wall or makes the pharmaceutical formulation (7.1-7.5) appear opaque through any transparent container wall, so that the appearance of the container wall and/or of the pharmaceutical formulation, for example whether it is a coloured, liquid, pulverulent, lyophilized or granular formulation, is visually undetectable for a user.

Description

  • The invention relates to a container according to the precharacterizing clause of claim 1 and packaging, for example packaging for remedies, comprising a plurality of such containers according to the precharacterizing clause of Claim 10.
  • Containers and packagings of the type according to the invention are used, for example, in clinical trials of drugs or remedies. In such clinical trials, a large number of test subjects take the drugs to be tested, orally, parenterally or topically, over a predetermined time span and according to a special administration plan, and the reactions of the test subjects and the effects of the drugs are recorded and statistically evaluated.
  • In addition to the generally known blister packs which are also used for the above-mentioned purpose, there are also other pharmaceutical dosage forms, such as, for example, vials, syringes and ampoules, which contain, for example, liquid drugs and drugs to be dissolved in a liquid and to be administered, for example, orally or by injection. Such dosage forms, too, are increasingly being used for clinical trials, in these applications the drugs to be tested already being present, together with the control and reference preparations likewise required for statistical evaluation, in sealed containers for provision of packaging according to the invention.
  • Both the quality assurance and the security of the data relating to content and use of the packed remedy are becoming increasingly important in medicine. This applies very particularly to drugs or remedies whose pharmaceutical effects are to be established with certainty by means of numerical statistical investigations.
  • Statistically significant evaluations of the clinical trials moreover require that various preparations and/or formulations thereof be used in, for example, a predetermined sequence within a test series and that these have standard appearance regardless of their initial packaging, their colour, their initial labelling or the like.
  • It is an object of the invention to propose, with the use of vials, ampoules and the like, a novel container which takes account of the requirements cited last.
  • This object is achieved by a container having the features of Claim 1 and packaging consisting of a plurality of containers having the features of Claim 10.
  • Advantageous embodiments of the invention form the subject of the claims dependent on Patent Claim 1.
  • An embodiment of the invention is explained in more detail below with reference to the drawing. In the drawing,
  • FIG. 1 shows a container drawn partly in section and partly as a view,
  • FIG. 2 shows a view of a covering formed from plastic, in the unfolded state,
  • FIG. 2 a shows a view in the direction of arrow IIa of FIG. 2
  • FIG. 3 shows a view of the container with mounted plastic covering,
  • FIG. 3 a shows a view in the direction of arrow IIIa of FIG. 3,
  • FIG. 4 shows, by way of example, five containers according to FIG. 1, intended for medical packaging, and
  • FIG. 5 shows the five containers of FIG. 4 in the dosage form as used in packaging of the type according to the invention.
  • The container shown in FIGS. 1 and 3 to 5 and denoted as a whole by 1, also referred to below as a vial, has a transparent, for example glass-clear, glass or plastic wall 2 with a base 3 and a plug 5 which fits detachably or nondetachably in the bottleneck 4 and has an associated lid 6. The lid 6 is formed and dimensioned in such a way that, in the fastened state, it projects over the edge of the filling orifice, or over the bottleneck 4 in the examples present here.
  • According to the invention, it is intended to surround the vial 1 by a covering 8 arranged on the outside of the container wall 2 and making the pharmaceutical formulation 7 contained in the container appear opaque through the transparent container wall 2, so that the appearance of the pharmaceutical formulation, for example whether it is a coloured, pulverulent, lyophilized or granular formulation, is visually undetectable for a user.
  • In one embodiment of the invention, the covering 8, as shown in FIG. 2, consists of a premoulded plastic jacket which fits tightly against the container wall 2 and is formed, for example, from two parts 8 a and 8 b intended for enclosing the container 1 and connected to one another along a generating line.
  • The two parts 8 a and 8 b each form a neck section 8 c and 8 d fitting the bottleneck 4, and the covering 8 is, for example, translucent and coloured, milky or cloudy.
  • The covering 8 consists, for example, of pure plastic, such as, for example, of polyethylene or polyvinyl chloride or of another plastic serving the purpose according to the invention, or of a combination of materials comprising a plastic film with, for example, aluminium or paper, or of a laminated foil.
  • According to the invention, the covering 8 can be arranged detachably or nondetachably on the container wall 2. If the covering 8 is to be arranged detachably on the container wall 2, it is closed, for example, by means of an adhesive strip preferably enclosing it completely or by means of an adhesive. If, however, the covering 8 is to be fastened nondetachably on the container wall 2, the covering 8 is, for example, adhesively bonded to the wall 2 over the whole surface or part of the surface.
  • In a further developed embodiment of the invention, at least one outer note or label which can be wrapped around the covering 8 and has information relating to content, administration times and the like can additionally be provided on the covering 8.
  • A packaging according to the invention, intended for remedies and comprising a plurality of containers 1 (1.1 to 1.5) each containing a pharmaceutical formulation 7 (7.1 to 7.5), is distinguished by the fact that all containers 1.1 to 1.5 are provided with a standard covering 8 of the type described above so that the appearances of the pharmaceutical formulations 7.1 to 7.5 cannot be visually distinguished from one another by a user, which is shown graphically in FIG. 5. The coverings 8 may all be translucent and coloured, milky or cloudy.
  • A substantial advantage of a packaging according to FIG. 5 for remedies thus consists in the fact that the different preparations provided inside the packaging have a standard appearance to the user or to the test subject, regardless of the type of their pharmaceutical formulations.
  • Finally, it should be pointed out here that the example of the invention described with references to FIGS. 1 to 5 represents only a selection of a plurality of possible embodiments of the invention and can be modified in various respects.
  • Thus, coverings 8 which are coloured or black or white and nontransparent or translucent in such a way that the appearance of the container wall 2 itself, for example its colour or its initial labelling, is undetectable are proposed, for example, for containers having a nontransparent container wall.
  • Furthermore, nontransparent coverings 8, for example premoulded coloured, black or white plastic films, can also be used for containers having a transparent container wall.
  • Furthermore, the containers according to the invention may also be in the form of an ampoule or a syringe instead of a vial. In the context of the invention, however, the container can of course have any desired shape, depending on the respective application, it being possible for said shape to vary greatly according to field of use, for example in chemistry, medicine or the food industry, as well as in its dimensions.

Claims (20)

1-10. (Cancelled)
11. A container for containing a pharmaceutical formulation comprising:
one of a transparent and a nontransparent wall having an outside surface;
a covering provided on the outside surface of the container wall being formed in such a way that the appearance of the container wall or of the pharmaceutical formulation selectively received within the container is visually undetectable for a user.
12. A container according to claim 11, wherein the container is used in a clinical trial wherein the user is a test subject taking the pharmaceutical formulation.
13. A container according to claim 11, wherein the container is one of a blister pack, a vial, a syringe and an ampoule.
14. A container according to claim 11, wherein when the container wall is nontransparent, the covering changes the appearance of the container wall and when the container wall is transparent, the pharmaceutical formulation appears opaque.
15. A container according to claim 11, wherein the covering includes a premolded plastic jacket fitted against the container wall.
16. A container according to claim 15, wherein the plastic jacket is arranged detachably on the container wall, and further that the jacket is closed by means of an adhesive strip enclosing the jacket or by means of an adhesive.
17. A container according to claim 15, wherein the plastic jacket is permanently attached to the container wall, and further that the jacket is firmly and permanently bonded to the container wall.
18. A container according to claim 11, wherein the covering is arranged detachably on the container wall.
19. A container according to claim 11, wherein the covering is permanently attached to the container wall.
20. A container according to claim 11, further including at least one of an outer note and a label, and wherein the at least one of the outer note and the label is wrapped around the covering.
21. A container according to claim 11, wherein the covering is colored one of black and white.
22. A container according to claim 11, wherein the covering is one of nontransparent and translucent.
23. A container according to claim 11, wherein the covering is milky or cloudy.
24. A container according to claim 11, wherein the container is one of an ampoule, syringe and vial.
25. A packaging for remedies comprising:
a plurality of containers each selectively containing a pharmaceutical formulation where the containers are all provided with a covering so that the appearance of the container walls or the pharmaceutical formulations are visually indistinguishable from one another for the user.
26. A packaging according to claim 25, wherein the containers are used in a clinical trial and wherein the user is a test subject taking the pharmaceutical formulation.
27. A packaging according to claim 25, wherein when the container wall is nontransparent, the covering changes the appearance of the container wall and when the container wall is transparent, the pharmaceutical formulation appears opaque.
28. A packaging according to claim 25, wherein the container is one of a blister pack, a vial, a syringe and an ampoule.
29. A packaging according to claim 25, wherein the pharmaceutical formulation is one of a solid drug, a liquid drug and a drug to be dissolved in a liquid.
US10/736,957 2002-12-19 2003-12-16 Vials-blinding solution (container and its use in packaging, for example packaging for remedies) Abandoned US20050016892A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH20022171/02 2002-12-19
CH02171/02A CH696069A5 (en) 2002-12-19 2002-12-19 Container and its use in a package, for example, remedy package.

Publications (1)

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US20050016892A1 true US20050016892A1 (en) 2005-01-27

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US10/534,767 Active 2025-07-02 US8007883B2 (en) 2002-12-19 2003-12-15 Container comprising a transparent cylindrical container wall
US10/736,957 Abandoned US20050016892A1 (en) 2002-12-19 2003-12-16 Vials-blinding solution (container and its use in packaging, for example packaging for remedies)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US10/534,767 Active 2025-07-02 US8007883B2 (en) 2002-12-19 2003-12-15 Container comprising a transparent cylindrical container wall

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US (2) US8007883B2 (en)
EP (2) EP1572546B1 (en)
JP (1) JP4469725B2 (en)
AU (1) AU2003303212A1 (en)
CA (1) CA2493089A1 (en)
CH (1) CH696069A5 (en)
DK (1) DK1572546T3 (en)
WO (1) WO2004056668A1 (en)

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US20070295060A1 (en) * 2006-06-13 2007-12-27 Delgado Juan C Ampoule card leak detector assembly

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JP4985425B2 (en) * 2008-01-24 2012-07-25 日本電気株式会社 Liquid container, method for producing the same, and liquid extraction method
USD746045S1 (en) 2013-12-03 2015-12-29 Novo Nordisk A/S Container for medical purposes
JP6933886B2 (en) * 2015-08-11 2021-09-08 エーザイ・アール・アンド・ディー・マネジメント株式会社 Labels, clinical trial bottles, labeling methods and methods that make it difficult to identify the contents
GB2577291B (en) * 2018-09-20 2022-11-09 Simon Aylett Moore Kenneth Masking package
US11542083B2 (en) 2019-09-30 2023-01-03 Fisher Clinical Services, Inc. Vial blinding assemblies and methods of assembly
WO2021096823A1 (en) * 2019-11-15 2021-05-20 Merck Sharp & Dohme Corp. Labeling shell for a drug vial
US20210186811A1 (en) * 2019-12-23 2021-06-24 Fisher Clinical Services, Inc. Hinged blinding shell for hanging a vial and related methods

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Also Published As

Publication number Publication date
CH696069A5 (en) 2006-12-15
AU2003303212A1 (en) 2004-07-14
US8007883B2 (en) 2011-08-30
CA2493089A1 (en) 2004-07-08
EP1572546A1 (en) 2005-09-14
JP4469725B2 (en) 2010-05-26
JP2006501041A (en) 2006-01-12
US20060037928A1 (en) 2006-02-23
EP1572546B1 (en) 2015-07-08
WO2004056668A1 (en) 2004-07-08
DK1572546T3 (en) 2015-10-19
EP1435329A1 (en) 2004-07-07

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AS Assignment

Owner name: FISHER CLINICAL SERVICES AG, SWITZERLAND

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:DUERR, ALAIN;REEL/FRAME:015772/0241

Effective date: 20040805

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION