US20030040782A1 - Heat exchange catheter having a helically wrapped heat exchanger - Google Patents
Heat exchange catheter having a helically wrapped heat exchanger Download PDFInfo
- Publication number
- US20030040782A1 US20030040782A1 US10/205,066 US20506602A US2003040782A1 US 20030040782 A1 US20030040782 A1 US 20030040782A1 US 20506602 A US20506602 A US 20506602A US 2003040782 A1 US2003040782 A1 US 2003040782A1
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- Prior art keywords
- heat exchange
- catheter
- fluid
- balloon
- lumen
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
- A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
- A61F7/123—Devices for heating or cooling internal body cavities using a flexible balloon containing the thermal element
Definitions
- This invention relates to heat exchange catheters, and particularly to catheters that exchange heat with the blood stream of a patient.
- Heat exchange catheters are used in many instances for a variety of reasons. Some surgeries, for example, are better performed when the patient cools to a hypothermic state. In other instances, a patient may suffer from accidental hypothermia and may need to be warmed to a normothermic temperature e.g. 98 . 6 F. Some heat exchange catheters include the capability of infusing fluids such as nutrition, medicine and contrast agents into the blood.
- Heat exchange catheter balloons can be sized having an external volume that optimally exchanges heat with the flowing blood.
- the balloon internal volume is large enough to inhibit optimal mixing of the heat exchange fluid.
- Boundary layers of heat exchange fluid can form in the interior of such balloons, lowering the temperature gradient between the heat exchange fluid at the balloon internal surface and ultimately reducing the effective rate of heat transfer between the heat transfer fluid and the flowing blood.
- Heat exchange catheters have been developed that deliver the heat exchange fluid to the distal end of the catheter via an insulated delivery lumen, causing the heat exchange fluid to maintain a relatively uniform temperature until the heat exchange fluid returns via a return lumen to exchange heat with the flowing blood. This improves the temperature gradient between the heat exchange fluid within the interior balloon walls and the flowing blood, unfortunately, the residence time that the heat exchange fluid interacts with the flowing blood is limited.
- Blood has a maximum desirable heating limit because above certain temperatures blood proteins can degenerate and coagulation may occurr. This limits the maximum operating temperature of known intravasculature catheters. Because the operating temperature of an intravascular catheter is limited, the catheter geometry takes on an increased importance to effectuate overall heat transfer.
- the first and second balloons are inflatable from a flattened configuration where the balloons lie flush with the catheter body to an operational configuration where the heat exchange fluid inflates the balloons.
- the flattened configuration facilitates insertion of the catheter into the body of a patient.
- the catheter inserts into the central vasculature.
- the catheter body defines a core extending between the proximal region and the distal region.
- the inflow lumen and the outflow lumen being defined within the core in the proximal region.
- the balloons further define the inflow and outflow lumens in the distal region.
- the core also defines a guidewire lumen.
- the first balloon and second balloon wrap around the distal region.
- the balloons define a gap there between.
- the balloons tightly wrap and forms a gap only to expose an exit port. Both of these aspects of the invention include the catheter body defining at least one infusion lumen having an exit port located in the gap.
- the first balloon and second balloon wrap tightly around the distal region of the core without a gap between the first and second balloon.
- a sheath surrounds the first and second balloons to inhibit coagulate formation.
- the sheath is distanced from the first and second balloons according to a variation of the invention.
- the sheath contacts the first and second balloons according to an alternate variation of the invention.
- FIG. 1 shows a heat exchange catheter in accordance with the present invention.
- FIG. 2A shows a cross-section of the catheter as seen along line A-A of FIG. 1
- FIG. 2B shows a cross-section of the catheter as seen along line B-B of FIG. 1.
- FIG. 2C shows a cross-section of the catheter as seen along line C-C of FIG. 1.
- FIG. 3 shows a partial longitudinal-section of the distal region per FIG. 1.
- FIG. 4 shows an embodiment of the distal region in accordance with the invention.
- FIG. 5 shows an embodiment of the distal region in accordance with the invention.
- FIG. 6 shows an embodiment of the distal region in accordance with the invention.
- the catheter 10 includes an infusion lumen 30 and an infusion lumen 32 , which terminate at infusion port 34 and infusion port 36 , respectively.
- the first balloon 24 and the second balloon 26 wrap in a helical pattern to form a helical gap there between.
- Infusion port 34 and infusion port 36 are located in the helical gap.
- the infusion lumens 30 and 32 facilitate infusion of fluids such as nutrients, medicines, contrast agents and the like through the infusion ports 34 and 36 .
- the catheter 10 defines a centrally located guidewire lumen that also functions to facilitate infusion of fluids.
- a heat exchange fluid is pumped via the inflow lumen 14 into the first balloon 24 .
- the heat exchange fluid reaches the tip 22 of the catheter body 12 . From the tip 22 , the heat exchange fluid returns via the second balloon 26 and the outflow lumen 16 .
- the temperature, pressure, and flow rate of the heat exchange fluid is regulated externally. It can be appreciated, however, that the catheter 10 can be equipped with sensors and supplemental heating/cooling elements to further monitor and regulate the temperature, pressure and flow rate of the heat exchange fluid. Optimally, the catheter 10 is designed for intravascular use. It is conceivable, however, that the catheter 10 can be used in various internal regions of the body.
- the catheter body 12 defines a core 27 extending between the proximal region 18 and the distal region 20 .
- the inflow lumen 14 and the outflow lumen 16 are defined within the core, in the proximal region 18 .
- FIG. 2A shows a cross-section of the proximal region 18 of the catheter body 12 .
- the proximal region 18 defines a guidewire lumen 28 , two infusion lumens 30 and 32 .
- the inflow lumen 14 and the outflow lumen 16 are defined within the catheter body 12 .
- FIG. 4 shows a sheath 50 surrounding the balloon 24 .
- the sheath 50 prevents coagulum from forming within the gap 46 .
- the sheath 50 is distanced from the balloon 24 in a radial direction from the distal region 20 according to one aspect of the invention.
- the sheath 50 contacts the balloon 24 .
- an infusion port or ports can be formed within the gap 46 .
- FIG. 5 shows a single balloon 26 on the distal region 20 .
- the balloon 26 has ends 60 and 62 and is helically wrapped to form a gap 46 between successive coils.
- the gap 46 extends along a helical path between the ends 60 and 62 .
- Infusion ports 34 and 36 are positioned near each end 60 and 62 of the balloon 26 , and within the gap 46 .
- FIG. 6 shows a single balloon 36 on the distal region 20 .
- the balloon 36 wraps tightly around the distal region 20 , maintaining contact with itself without forming a helical gap. It can be appreciated that when an infusion port formed on the catheter 10 requires exposure, the balloon 36 is conformed with a small gap to expose the infusion port.
- the heat exchange occurs through dual helical balloons.
- One helical balloon circulates fluid from the inflow lumen, the other circulates fluid through the outflow lumen along a helical path.
- the heat exchange fluid inflates both balloons from a flattened configuration to an operational configuration.
- the operational configuration includes inflating the balloons to a round or an oval cross-sectional configuration.
- the core of the catheter can inflow heat exchange fluid to the distally mounted heat exchange balloon(s).
- the balloon(s) can inflow the heat exchange fluid and the core can outflow the heat exchange fluid.
- the present invention includes two helical balloons, one inflows heat exchange fluid and the other outflows the heat exchange fluid. Many variations of this concept are possible. Accordingly, the present invention should be limited only by the following claims.
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Thermal Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
A heat exchange catheter has a catheter body with an inflow lumen, an outflow lumen, and an infusion lumen. A first heat exchange balloon helically wraps around at least a portion of the catheter body in fluid communication with the inflow lumen. A second heat exchange balloon helically wraps around at least a portion of the catheter body in fluid communication with the outflow lumen. The first and second balloons form a gap there between to facilitate infusion of fluid into the blood stream of the patient via an infusion port formed within the gap.
Description
- This is a continuation application of U.S. patent application Ser. No. 09/791,391, filed Feb. 22, 2001, the disclosures of which are incorporated herein by reference in their entirety.
- This invention relates to heat exchange catheters, and particularly to catheters that exchange heat with the blood stream of a patient.
- Heat exchange catheters are used in many instances for a variety of reasons. Some surgeries, for example, are better performed when the patient cools to a hypothermic state. In other instances, a patient may suffer from accidental hypothermia and may need to be warmed to a normothermic temperature e.g.98.6 F. Some heat exchange catheters include the capability of infusing fluids such as nutrition, medicine and contrast agents into the blood.
- Post surgical patients risk infection and fever. A fever can be controlled through the use of a heat exchange system having an intravascular heat exchange catheter. One such system is disclosed in U.S. Pat. No. 6,146,411. This US Patent is incorporated herein by reference and teaches an exemplary system used to achieve patient normothermia.
- The principals of heat exchange applicable to any flowing medium (including blood) dictates the amount of heat transfer. In blood, the heat transferred depends on many things including the volumetric flow rate of the blood, the geometry of the heat exchanger and the temperature difference between the heat exchanger and the blood.
- Various heat exchange catheter designs have been developed. U.S. Pat. No. 6,126,684, for example, teaches a heat exchange catheter having tubular balloons in serial alignment to exchange heat with the blood stream of a patient. This U.S. Patent is incorporated herein by reference. The balloons allow for a relatively large surface area of contact for heat exchange. Infusion lumen exit ports are defined between the balloons. Unfortunately, these exit port regions limit the effective heat exchange surface area.
- Heat exchange catheter balloons can be sized having an external volume that optimally exchanges heat with the flowing blood. The balloon internal volume, however, is large enough to inhibit optimal mixing of the heat exchange fluid. Boundary layers of heat exchange fluid can form in the interior of such balloons, lowering the temperature gradient between the heat exchange fluid at the balloon internal surface and ultimately reducing the effective rate of heat transfer between the heat transfer fluid and the flowing blood.
- Heat exchange catheters have been developed that deliver the heat exchange fluid to the distal end of the catheter via an insulated delivery lumen, causing the heat exchange fluid to maintain a relatively uniform temperature until the heat exchange fluid returns via a return lumen to exchange heat with the flowing blood. This improves the temperature gradient between the heat exchange fluid within the interior balloon walls and the flowing blood, unfortunately, the residence time that the heat exchange fluid interacts with the flowing blood is limited.
- Blood has a maximum desirable heating limit because above certain temperatures blood proteins can degenerate and coagulation may occurr. This limits the maximum operating temperature of known intravasculature catheters. Because the operating temperature of an intravascular catheter is limited, the catheter geometry takes on an increased importance to effectuate overall heat transfer.
- What is desired is a heat exchange catheter having a geometry that is optimally designed for transferring heat to flowing blood.
- A heat exchange catheter includes a catheter body having an inflow lumen, an outflow lumen, a proximal region and a distal region. A first balloon helically wraps around at least a portion of the catheter body and maintains fluid communication with the inflow lumen. A second balloon helically wraps around at least a portion of the catheter body and maintains in fluid communication with the outflow lumen. The first and second balloons forming a fluid circuit to facilitate circulation of a heat exchange fluid through the first balloon and the second balloon.
- Optimally, the first and second balloons are inflatable from a flattened configuration where the balloons lie flush with the catheter body to an operational configuration where the heat exchange fluid inflates the balloons. The flattened configuration facilitates insertion of the catheter into the body of a patient. Preferably, the catheter inserts into the central vasculature.
- The catheter body defines a core extending between the proximal region and the distal region. The inflow lumen and the outflow lumen being defined within the core in the proximal region. The balloons further define the inflow and outflow lumens in the distal region. The core also defines a guidewire lumen.
- The first balloon and second balloon wrap around the distal region. According to one aspect of the invention, the balloons define a gap there between. According to an alternate aspect of the invention, the balloons tightly wrap and forms a gap only to expose an exit port. Both of these aspects of the invention include the catheter body defining at least one infusion lumen having an exit port located in the gap.
- According to one aspect of the invention, the first balloon and second balloon wrap tightly around the distal region of the core without a gap between the first and second balloon.
- According to another aspect of the invention, a sheath surrounds the first and second balloons to inhibit coagulate formation. The sheath is distanced from the first and second balloons according to a variation of the invention. The sheath contacts the first and second balloons according to an alternate variation of the invention.
- FIG. 1 shows a heat exchange catheter in accordance with the present invention.
- FIG. 2A shows a cross-section of the catheter as seen along line A-A of FIG. 1
- FIG. 2B shows a cross-section of the catheter as seen along line B-B of FIG. 1.
- FIG. 2C shows a cross-section of the catheter as seen along line C-C of FIG. 1.
- FIG. 3 shows a partial longitudinal-section of the distal region per FIG. 1.
- FIG. 4 shows an embodiment of the distal region in accordance with the invention.
- FIG. 5 shows an embodiment of the distal region in accordance with the invention.
- FIG. 6 shows an embodiment of the distal region in accordance with the invention.
- FIG. 1 shows a heat exchange catheter, generally designated with the
reference numeral 10. Thecatheter 10 includes acatheter body 12 having aninflow lumen 14, anoutflow lumen 16, aproximal region 18, adistal region 20, and adistal tip 22. Thecatheter 10 also includes afirst balloon 24 helically wrapping around thedistal region 20 of thecatheter body 12 and being in fluid communication with theinflow lumen 14. Thecatheter 10 further includes asecond balloon 26 helically wrapping around thedistal region 20 of thecatheter body 12 and being in fluid communication with theoutflow lumen 16. Thefirst balloon 24 and thesecond balloon 26 connect in fluid communication in thetip 22 of thecatheter body 12 to form a fluid circuit. - The
catheter 10 includes aninfusion lumen 30 and aninfusion lumen 32, which terminate atinfusion port 34 andinfusion port 36, respectively. Thefirst balloon 24 and thesecond balloon 26 wrap in a helical pattern to form a helical gap there between.Infusion port 34 andinfusion port 36 are located in the helical gap. Theinfusion lumens infusion ports catheter 10 defines a centrally located guidewire lumen that also functions to facilitate infusion of fluids. - A heat exchange fluid is pumped via the
inflow lumen 14 into thefirst balloon 24. The heat exchange fluid reaches thetip 22 of thecatheter body 12. From thetip 22, the heat exchange fluid returns via thesecond balloon 26 and theoutflow lumen 16. - The temperature, pressure, and flow rate of the heat exchange fluid is regulated externally. It can be appreciated, however, that the
catheter 10 can be equipped with sensors and supplemental heating/cooling elements to further monitor and regulate the temperature, pressure and flow rate of the heat exchange fluid. Optimally, thecatheter 10 is designed for intravascular use. It is conceivable, however, that thecatheter 10 can be used in various internal regions of the body. - The
catheter body 12 defines a core 27 extending between theproximal region 18 and thedistal region 20. Theinflow lumen 14 and theoutflow lumen 16 are defined within the core, in theproximal region 18. - FIG. 2A shows a cross-section of the
proximal region 18 of thecatheter body 12. Theproximal region 18 defines aguidewire lumen 28, twoinfusion lumens inflow lumen 14 and theoutflow lumen 16 are defined within thecatheter body 12. - FIG. 2B shows a cross-section of the
distal region 20 of thecatheter body 12. Theballoons balloons heat exchange fluid 38, which inflates theballoons heat exchange catheter 10. - FIG. 2C shows a cross-section of the
distal tip 22 of thecatheter body 12. Thedistal tip 22 includes theguidewire lumen 28 and atransition region 40. Thetransition region 40 joins the inflow lumen and the outflow lumen in fluid communication. - FIG. 3 shows a portion of the
distal region 20. Theballoon 24 carries the heat exchange fluid in the direction of thearrow 42, towards thedistal tip 22. Theballoon 26 carries heat exchange fluid in the direction of thearrow 44, away from thedistal tip 22. Theballoon 24 and theballoon 26 define agap 46 there between. Thegap 46 extends along a helical path between theballoons infusion ports distal region 20, within thegap 46. - The
gap 46 distances theballoons balloons balloons gap 46 also enables positioning of theinfusion ports proximal region 20. According to one aspect of the invention, theguidewire lumen 28 functions to infuse fluids through thedistal tip 22. - FIG. 4 shows a
sheath 50 surrounding theballoon 24. Thesheath 50 prevents coagulum from forming within thegap 46. Thesheath 50 is distanced from theballoon 24 in a radial direction from thedistal region 20 according to one aspect of the invention. According to an alternate aspect of the invention, thesheath 50 contacts theballoon 24. According to a further aspect of the invention, an infusion port or ports can be formed within thegap 46. - FIG. 5 shows a
single balloon 26 on thedistal region 20. Theballoon 26 has ends 60 and 62 and is helically wrapped to form agap 46 between successive coils. Thegap 46 extends along a helical path between theends Infusion ports end balloon 26, and within thegap 46. - FIG. 6 shows a
single balloon 36 on thedistal region 20. Theballoon 36 wraps tightly around thedistal region 20, maintaining contact with itself without forming a helical gap. It can be appreciated that when an infusion port formed on thecatheter 10 requires exposure, theballoon 36 is conformed with a small gap to expose the infusion port. - A method of circulating fluid within a heat exchange catheter includes inserting the heat exchange catheter into the central vasculature of a patient. The proximal portion of the catheter is secured to the patient to prevent catheter movement.
- The next step includes circulating a heat exchange fluid through the inflow lumen of a heat exchange catheter. The heat exchange fluid circulates along a helical path to exchange heat with the blood stream of a patient. One benefit of circulating the heat exchange fluid along a helical path is that the residence time that the heat exchange fluid transfers heat is increased compared with tubular heat exchanger systems. Another benefit circulating the heat exchange fluid along a helical path is that the helical path causes fluid mixing within the catheter. This mixing causes vortices, which disrupts the heat exchange fluid at the boundary layer located at the wall of the inflow and out flow lumens. Further, the helical shape causes blood to flow, turbulently under some conditions, past the heat exchange catheter to improve heat transfer between the heat exchange catheter and the blood.
- To add medicine, nutrition, contrast agents and the like, the step of infusing fluid into the blood stream via the heat exchange catheter is performed.
- According to one aspect of the invention, the heat exchange occurs through dual helical balloons. One helical balloon circulates fluid from the inflow lumen, the other circulates fluid through the outflow lumen along a helical path. The heat exchange fluid inflates both balloons from a flattened configuration to an operational configuration. Preferably, the operational configuration includes inflating the balloons to a round or an oval cross-sectional configuration.
- It can be appreciated that the core of the catheter can inflow heat exchange fluid to the distally mounted heat exchange balloon(s). Alternatively, the balloon(s) can inflow the heat exchange fluid and the core can outflow the heat exchange fluid. Optimally, however, the present invention includes two helical balloons, one inflows heat exchange fluid and the other outflows the heat exchange fluid. Many variations of this concept are possible. Accordingly, the present invention should be limited only by the following claims.
Claims (10)
1. A heat exchange catheter comprising:
a catheter body having a core, an inflow lumen, an outflow lumen, a proximal region and a distal region;
a balloon helically wrapping around at least a portion of the catheter body and being in fluid communication with the core and at least one of the inflow lumen or the outflow lumen;
the core fluidly communicating with the other of the at least one of the inflow lumen or the outflow lumen;
the balloon and the core forming a fluid circuit to facilitate circulation of a heat exchange fluid through the balloon and the core to exchange heat with a patient.
2. The heat exchange catheter of claim 1 wherein the balloon is in fluid communication with the inflow lumen.
3. The heat exchange catheter of claim 1 wherein the balloon is in fluid communication with the outflow lumen.
4. The heat exchange catheter of claim 1 further comprising at least one infusion port on the catheter body for infusing a fluid such as nutrients, medication or saline into the patient.
5. The heat exchange catheter of claim 1 wherein the distal portion includes a distal tip comprising a port opening located on the distal tip for infusing a fluid such as nutrients, medication or saline into the patient or for accommodating a guidewire.
6. A method of circulating a heat exchange fluid within a heat exchange catheter, comprising:
circulating the heat exchange fluid through the catheter to exchange heat with the blood stream of a patient, the heat exchange fluid being circulated from a fluid source external to the catheter;
returning the heat exchange fluid through the core of the catheter to the fluid source; and
infusing an infusion fluid into the blood stream of the patient via the catheter.
7. The method of claim 6 wherein the heat exchange fluid through the catheter is circulated along a helical path.
8. The method of claim 6 wherein the heat exchange fluid through the catheter is circulated along the balloon.
9. A method of circulating a heat exchange fluid within a heat exchange catheter, comprising:
circulating the heat exchange fluid through the core of the catheter to exchange heat with the blood stream of a patient, the heat exchange fluid being circulated from a fluid source external to the catheter;
returning the heat exchange fluid through the balloon of the catheter to the fluid source; and
infusing an infusion fluid into the blood stream of the patient via the catheter.
10. The method of claim 9 wherein the heat exchange fluid is circulated at least partially through along a helical path.
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US10/205,066 US20030040782A1 (en) | 2001-02-22 | 2002-07-25 | Heat exchange catheter having a helically wrapped heat exchanger |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US09/791,391 US6451045B1 (en) | 2001-02-22 | 2001-02-22 | Heat exchange catheter having a helically wrapped heat exchanger |
US10/205,066 US20030040782A1 (en) | 2001-02-22 | 2002-07-25 | Heat exchange catheter having a helically wrapped heat exchanger |
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US09/791,391 Continuation US6451045B1 (en) | 2001-02-22 | 2001-02-22 | Heat exchange catheter having a helically wrapped heat exchanger |
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US20030040782A1 true US20030040782A1 (en) | 2003-02-27 |
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US09/791,391 Expired - Lifetime US6451045B1 (en) | 2001-02-22 | 2001-02-22 | Heat exchange catheter having a helically wrapped heat exchanger |
US10/205,066 Abandoned US20030040782A1 (en) | 2001-02-22 | 2002-07-25 | Heat exchange catheter having a helically wrapped heat exchanger |
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US09/791,391 Expired - Lifetime US6451045B1 (en) | 2001-02-22 | 2001-02-22 | Heat exchange catheter having a helically wrapped heat exchanger |
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Cited By (13)
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US6702841B2 (en) | 1998-01-23 | 2004-03-09 | Innercool Therapies, Inc. | Method of manufacturing a heat transfer element for in vivo cooling |
US20040064170A1 (en) * | 2002-09-30 | 2004-04-01 | Radons Stephen W. | Rapid induction of mild hypothermia |
US20040106969A1 (en) * | 1998-01-23 | 2004-06-03 | Innercool Therapies, Inc. | Inflatable catheter for selective organ heating and cooling and method of using the same |
US20040210285A1 (en) * | 2002-04-04 | 2004-10-21 | Steven Yon | Method of manufacturing a heat transfer element for in vivo cooling without undercuts |
US20050076924A1 (en) * | 1998-01-23 | 2005-04-14 | Dobak John D. | Medical procedure |
US20060089689A1 (en) * | 2004-10-22 | 2006-04-27 | Hennemann Willard W | Method and device for local cooling within an organ using an intravascular device |
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US10363162B2 (en) | 2009-02-26 | 2019-07-30 | Advanced Cooling Therapy, Inc. | Devices and methods for controlling patient temperature |
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US6585752B2 (en) | 1998-06-23 | 2003-07-01 | Innercool Therapies, Inc. | Fever regulation method and apparatus |
US6464716B1 (en) | 1998-01-23 | 2002-10-15 | Innercool Therapies, Inc. | Selective organ cooling apparatus and method |
US6051019A (en) | 1998-01-23 | 2000-04-18 | Del Mar Medical Technologies, Inc. | Selective organ hypothermia method and apparatus |
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US6702811B2 (en) | 1999-04-05 | 2004-03-09 | Medtronic, Inc. | Ablation catheter assembly with radially decreasing helix and method of use |
US6450987B1 (en) | 2001-02-01 | 2002-09-17 | Innercool Therapies, Inc. | Collapsible guidewire lumen |
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US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US6796995B2 (en) * | 2002-08-30 | 2004-09-28 | Alsius Corporation | Intravascular temperature control catheter |
US20040199114A1 (en) * | 2003-04-01 | 2004-10-07 | Alsius Corporation | Intravascular heat exchange catheter with tissue preservative |
US6893454B2 (en) * | 2003-04-28 | 2005-05-17 | Alsius Corporation | Intrarectal heat exchange catheter |
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US7306623B2 (en) * | 2005-01-13 | 2007-12-11 | Medtronic Vascular, Inc. | Branch vessel graft design and deployment method |
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US20020116039A1 (en) | 2002-08-22 |
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