US20010011171A1 - Intradermal delivery device including a needle assembly - Google Patents
Intradermal delivery device including a needle assembly Download PDFInfo
- Publication number
- US20010011171A1 US20010011171A1 US09/825,395 US82539501A US2001011171A1 US 20010011171 A1 US20010011171 A1 US 20010011171A1 US 82539501 A US82539501 A US 82539501A US 2001011171 A1 US2001011171 A1 US 2001011171A1
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- Prior art keywords
- needle
- skin
- engaging surface
- limiter
- assembly
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0445—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/3278—Apparatus for destroying used needles or syringes
Definitions
- the present invention generally relates to delivery devices for delivering substances such as drugs, vaccines and the like, and more specifically relates to a drug delivery device for injecting such substances intradermally, i.e., into the skin.
- the present invention relates to a needle assembly that is adaptable for use with a variety of drug containers such as syringes for making intradermal injections.
- hypodermic injection devices are commercially available. Most hypodermic injections are intended to be intramuscular so that the hypodermic needle penetrates through an individual's skin layer and subcutaneous tissue and into the muscle tissue. Under some circumstances, however, limited needle penetration is desired. Under some circumstances, for example, an intradermal injection is desired where the needle does not penetrate beyond the dermis layer.
- Mantoux procedure One technique for administering intradermal injections is known as the Mantoux procedure.
- a Mantoux procedure is relatively complicated and requires technical skill from the medical professional or individual administering the injection. Additionally, the Mantoux procedure can prove painful for the individual receiving the injection, especially when somebody without experience is administering the injection.
- the present invention is directed to a drug delivery device including a needle assembly for use in making intradermal injections.
- the needle assembly has an adapter that is attachable to prefillable containers such as syringes and the like.
- the needle assembly is supported by the adapter and has a hollow body with a forward end extending away from the adapter.
- a limiter surrounds the needle and extends away from the adapter toward the forward end of the needle.
- the limiter has a skin engaging surface that is adapted to be received against the skin of an animal such as a human.
- the needle forward end extends away from the skin engaging surface a selected distance such that the limiter limits the amount or depth that the needle is able to penetrate through the skin of an animal.
- the present invention is directed to a method of intradermally injecting at least one substance into the skin including the steps of pressing the needle perpendicularly to the skin of the person to receive an injection, injecting the substance into skin of the person with the depth of penetration of the needle being mechanically limited to the intradermal space by the limiter that surrounds the needle.
- the step of pressing the needle perpendicularly to the skin of the person includes orienting the needle perpendicularly to the skin, and the step of injecting the substance either includes moving a plunger that is received within the reservoir or deflecting two sheets of thermoplastic material forming the reservoir toward each other to expel the substance from the reservoir during an injection.
- FIG. 1 is an exploded, perspective illustration of a needle assembly designed according to this invention.
- FIG. 2 is a partial cross-sectional illustration of the embodiment of FIG. 1.
- FIG. 3 shows the embodiment of FIG. 2 attached to a syringe body to form an injection device.
- FIG. 4 is an exploded, side view of another embodiment of an injection device designed according to this invention.
- FIG. 5 is a cross-sectional illustration taken along the lines A-A in FIG. 4 but showing the components in an assembled condition.
- FIG. 6 is an exploded, cross-sectional view similar to that shown in FIG. 5 showing an alternative embodiment.
- FIG. 7 shows the embodiment of FIG. 6 in an assembled condition.
- FIG. 8 is a flow chart diagram that schematically illustrates a method of filling a device designed according to this invention.
- FIGS. 1 and 2 diagrammatically illustrate the needle assembly 20 of the present invention that is designed to be used for making intradermal injections
- FIG. 3 illustrates the drug container such as syringe 60 for use with the needle assembly 20
- FIGS. 4 - 7 illustrated the intradermal delivery device 80 of the present invention for making intradermal injections.
- Intradermal injections include administering substances such as drugs, vaccines and the like into the skin of an animal such as a human.
- the needle assembly 20 includes a hub 22 that supports a needle 24 .
- the limiter 26 receives at least a portion of the hub 22 so that the limiter 26 generally surrounds the needle 24 as best seen in FIG. 2.
- One end 30 of the hub 22 is able to be secured to a receiver 32 of a syringe.
- a variety of syringe types can be used with a needle assembly designed according to this invention, with several examples being given below.
- the opposite end of the hub 22 preferably includes extensions 34 that are nestingly received against abutment surfaces 36 within the limiter 26 .
- a plurality of ribs 38 preferably are provided on the limiter 26 to provide structural integrity and to facilitate handling the needle assembly 20 .
- a distance d between a forward end or tip 40 of the needle 24 and a skin engaging surface 42 on the limiter 26 can be tightly controlled.
- the distance d preferably is in a range from approximately 0.5 millimeters to approximately 3 millimeters.
- an intradermal injection is ensured because the needle is unable to penetrate any further than the typical dermis layer of an animal.
- Typical tissue layers include an epidermis between 50 and 100 micrometers, a dermis layer between 2 and 3 mm then subcutaneous tissue followed by muscle tissue.
- the limiter 26 includes an opening 44 through which the forward end 40 of the needle 24 protrudes.
- the dimensional relationship between the opening 44 and the needle 40 can be controlled depending on the needs of a particular situation.
- the skin engaging surface 42 is generally planar and continuous and provides a stable placement of the needle assembly 20 against an animal's skin.
- the skin engaging surface may be slightly concave or convex in order to facilitate stretching or gathering the animal's skin in the vicinity of the needle tip 40 to facilitate making an injection.
- the ribs 38 may be extended beyond the skin engaging surface 42 to further facilitate manipulating the skin in the vicinity where the injection is to be given.
- the preferred embodiment includes enough of a surface area that contacts the skin to facilitate stabilizing the injector relative to the animal's skin.
- the skin engaging surface 42 facilitates maintaining the injector in a generally perpendicular orientation relative to the skin surface.
- FIGS. 1 and 2 illustrate a two-piece assembly where the hub 22 is made separate from the limiter 26 , this invention is not limited to such an arrangement. Forming the hub 22 and limiter 26 integrally from a single piece of plastic material is an alternative to the example shown in FIGS. 1 and 2. Additionally, it is possible to adhesively or otherwise secure the hub 22 to the limiter 26 in the position illustrated in FIG. 2 so that the needle assembly 20 becomes a single piece unit upon assembly.
- Having a hub 22 and limiter 26 provides the advantage of making an intradermal needle practical to manufacture.
- the preferred needle size is a small gauge hypodermic needle, commonly known as a 30 gauge or 31 gauge needle. Having such a small diameter needle presents a challenge to make a needle short enough to prevent undue penetration beyond the dermis layer of an animal.
- the limiter 26 and the hub 22 facilitate utilizing a needle 24 that has an overall length that is much greater than the effective length of the needle, which penetrates the individual's tissue during an injection.
- manufacturing is enhanced because larger length needles can be handled during the manufacturing and assembly processes while still obtaining the advantages of having a short needle for purposes of completing an intradermal injection.
- FIG. 3 illustrates a needle assembly 20 secured to a drug container such as a syringe 60 .
- a generally cylindrical syringe body 62 can be made of plastic or glass as is known in the art.
- the syringe body 62 provides a reservoir 64 for containing a substance to be administered during an injection.
- a plunger 66 has a manual activation flange 68 at one end with a stopper 70 at an opposite end as known in the art. Manual movement of the plunger 66 through the reservoir 64 forces the substance within the reservoir 64 out of the end 40 of the needle as desired.
- the hub 22 can be secured to the syringe body 62 in a variety of known manners.
- an interference fit is provided between the interior of the hub 22 and the exterior of the outlet port portion 72 of the syringe body 62 .
- a conventional luer fit arrangement is provided to secure the hub 22 on the end of the syringe 60 .
- a needle assembly designed according to this invention is readily adaptable to a wide variety of conventional syringe styles.
- FIGS. 4 and 5 illustrate an alternative embodiment of an intradermal delivery device 80 that includes a syringe made from two sheets of thermoplastic material.
- the syringe includes a body portion 82 that is generally flat and surrounds a reservoir 84 .
- An outlet port 86 allows fluid substance within the reservoir 84 to be communicated out of the reservoir to administer an injection.
- the syringe body preferably is formed using a thermoforming process as is known in the art.
- a receiver 90 includes a generally cylindrical neck portion 92 that preferably is secured to the outlet port 86 using a heating or welding process as known in the art.
- a flange 94 preferably rests against the body portion 82 of the syringe to provide structural integrity.
- An extension 96 extends away from the flange 94 in a direction opposite from the cylindrical portion 92 .
- the needle assembly 20 preferably is received within the extension 96 as shown in FIG. 5.
- the receiver 90 preferably supports a sealing membrane 100 that closes off the outlet port 86 so that the syringe can be prefilled.
- the needle assembly 20 preferably includes a back end 102 of the needle that penetrates the sealing membrane 100 when the hub 22 is received within the extension 96 .
- the side walls of the reservoir 84 preferably are squeezed between a thumb and index finger so that the side walls collapse towards each other and the substance within the reservoir 84 is expelled through the opening in the forward end 40 of the needle 24 .
- the hub 22 and limiter 26 preferably are integrally molded as a single piece of plastic material.
- a snap fit arrangement secures the hub 22 within the extension 96 of the receiver 90 .
- FIGS. 6 and 7. Another alternative is illustrated in FIGS. 6 and 7. In this embodiment, the hub 22 is molded separately from the limiter 26 ′, which is integrated with the extension 96 .
- 4 and 5 includes an elongated extension 96 so that the side wall of the extension 96 provides the skin engaging surface 42 ′ of the limiter 26 ′.
- the limiter is supported by the syringe body.
- FIG. 7 also illustrates a needle shield 110 , which preferably is provided on the hub 22 and needle 24 .
- the needle shield 110 facilitates inserting the hub 22 within the receiver 90 until the hub 22 is appropriately received within the extension 96 so that the intradermal delivery device 80 is ready for use.
- the needle shield 110 can be discarded after the hub 22 is in position.
- the needle shield 110 can be replaced over the needle 24 after an injection is complete to avoid the possibility for a needle stick while handling the intradermal delivery device 80 after it has been used.
- the shield 110 is only shown in FIG. 7, it preferably is utilized with the embodiments of FIGS. 4 - 7 .
- This invention provides an intradermal needle injector that is adaptable to be used with a variety of syringe types. Therefore, this invention provides the significant advantage of facilitating manufacture and assembly of intradermal needles on a mass production scale in an economical fashion.
- intradermal delivery device 80 of the present including the needle assembly 20 and drug container 60 , its operation and use is described below.
- FIG. 8 an example method of filling devices designed according to this invention is schematically illustrated in flow chart format.
- the device includes a syringe of the style illustrated in FIG. 3, the following basic procedure is useful for prefilling the syringes with a desired substance.
- a supply of syringe barrels 200 includes the desired form of syringe, such as those illustrated and discussed above.
- a locally controlled environment 202 preferably is maintained in a known manner.
- the locally controlled environment 202 preferably is situated to immediately accept the syringes without requiring any intermediate cleaning or sterilizing steps between the supply 200 and the environment 202 .
- the syringe barrels are washed with air at 204 to remove any particulates from the syringes.
- the syringes preferably are then coated at 206 with a lubricant such as a lubricating silicone oil on the inner surface.
- the lubricant facilitates moving the stopper 70 and plunger rod 66 through the syringe during actual use of the device.
- the end of syringes that eventually will needle assembly 20 may be capped with a tip cap within the environment 202 .
- tip caps are supplied at 208 .
- the tip caps are air washed at 210 .
- the cleaned tip caps and syringe barrels are conveyed to an assembly device 212 where the tip caps are secured onto the syringes.
- the syringe barrel assemblies are then conveyed to a filling station 214 to be filled with the desired substance.
- the stoppers 70 are inserted into the open end of the syringes at 220 . Prior to inserting the stoppers 70 , they preferably are assembled with the plunger rods 66 at 222 and lubricated at 224 with a conventional lubricant in a known manner. The assembled, filled syringes preferably are inspected at 226 for defects and discharged from the locally controlled environment.
- the syringes typically will be sterilized at 230 and packaged at 232 into individual packages or into bulk packaging depending on the needs of a particular situation. Suitable sterilization techniques are known and will be chosen by those skilled in the art depending on the needs of a particular situation or to accommodate the properties of a given substance. Sterilizing a device designed according to this invention can be completed before or after packaging.
- the stopper can be inserted first, then fill the syringe, followed by applying a tip cap.
- the filling operation obviously does not include insertion of a stopper nor the lubrication steps described above. Instead, appropriate filling techniques that are known are utilized.
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Abstract
A drug delivery device including a needle assembly facilitates making intradermal injections using a variety of drug container types such as a syringe. A hub supports the needle while a limiter surrounds the needle. The limiter includes a skin engaging surface that is adapted to be received against the skin of an animal to be intradermally injected. A forward end of the needle extends beyond the skin engaging surface a selected distance to limit a depth that the needle penetrates into the animal's skin.
Description
- The present invention generally relates to delivery devices for delivering substances such as drugs, vaccines and the like, and more specifically relates to a drug delivery device for injecting such substances intradermally, i.e., into the skin. In addition, the present invention relates to a needle assembly that is adaptable for use with a variety of drug containers such as syringes for making intradermal injections.
- A wide variety of hypodermic injection devices are commercially available. Most hypodermic injections are intended to be intramuscular so that the hypodermic needle penetrates through an individual's skin layer and subcutaneous tissue and into the muscle tissue. Under some circumstances, however, limited needle penetration is desired. Under some circumstances, for example, an intradermal injection is desired where the needle does not penetrate beyond the dermis layer.
- One technique for administering intradermal injections is known as the Mantoux procedure. A Mantoux procedure is relatively complicated and requires technical skill from the medical professional or individual administering the injection. Additionally, the Mantoux procedure can prove painful for the individual receiving the injection, especially when somebody without experience is administering the injection.
- Devices have been proposed for providing intradermal injections, which include shortened needles compared to conventional needle sizes. The smaller needles are not intended to penetrate beyond the dermis layer of the individual. Such devices are shown in U.S. Pat. Nos. 5,527,288, which issued on Jun. 18, 1996; 4,886,499, which issued on Dec. 12, 1989; and 5,328,483, which issued on Jul. 12, 1994. The proposed devices, however are not without shortcomings and drawbacks.
- For example, the devices shown in U.S. Pat. Nos. 5,527,288 and 4,886,499 are highly specialized injectors. The designs for these injectors include relatively complex arrangements of components that cannot be economically manufactured on a mass production scale. Therefore, such devices have limited applicability and use.
- Similarly, the device shown in U.S. Pat. No. 5,328,483 requires a specially designed injector and, therefore, it is not readily adapted to be used with a variety of syringe types. Additionally, the assembly of that patent is not conducive to economical mass production.
- There is need for an intradermal injection device that is suitable for use with a variety of syringe bodies. Additionally, there is a need for an intradermal injection device that can be economically manufactured on a mass production scale. This invention addresses those needs and avoids the shortcomings and drawbacks discussed above.
- In contrast to the prior devices discussed above, it has been found that a drug delivery device particularly suited for use in intradermally injecting substances such as drugs, vaccines and the like can be constructed in accordance with the present invention. Specifically, the present invention is directed to a drug delivery device including a needle assembly for use in making intradermal injections. The needle assembly has an adapter that is attachable to prefillable containers such as syringes and the like. The needle assembly is supported by the adapter and has a hollow body with a forward end extending away from the adapter. A limiter surrounds the needle and extends away from the adapter toward the forward end of the needle. The limiter has a skin engaging surface that is adapted to be received against the skin of an animal such as a human. The needle forward end extends away from the skin engaging surface a selected distance such that the limiter limits the amount or depth that the needle is able to penetrate through the skin of an animal.
- In addition, the present invention is directed to a method of intradermally injecting at least one substance into the skin including the steps of pressing the needle perpendicularly to the skin of the person to receive an injection, injecting the substance into skin of the person with the depth of penetration of the needle being mechanically limited to the intradermal space by the limiter that surrounds the needle. Also, in the preferred embodiment, the step of pressing the needle perpendicularly to the skin of the person includes orienting the needle perpendicularly to the skin, and the step of injecting the substance either includes moving a plunger that is received within the reservoir or deflecting two sheets of thermoplastic material forming the reservoir toward each other to expel the substance from the reservoir during an injection.
- The various features and advantages of this invention will become apparent to those skilled in the art from the following detailed description of the currently preferred embodiments. The drawings that accompany the detailed description can be briefly described as follows.
- FIG. 1 is an exploded, perspective illustration of a needle assembly designed according to this invention.
- FIG. 2 is a partial cross-sectional illustration of the embodiment of FIG. 1.
- FIG. 3 shows the embodiment of FIG. 2 attached to a syringe body to form an injection device.
- FIG. 4 is an exploded, side view of another embodiment of an injection device designed according to this invention.
- FIG. 5 is a cross-sectional illustration taken along the lines A-A in FIG. 4 but showing the components in an assembled condition.
- FIG. 6 is an exploded, cross-sectional view similar to that shown in FIG. 5 showing an alternative embodiment.
- FIG. 7 shows the embodiment of FIG. 6 in an assembled condition.
- FIG. 8 is a flow chart diagram that schematically illustrates a method of filling a device designed according to this invention.
- FIGS. 1 and 2 diagrammatically illustrate the
needle assembly 20 of the present invention that is designed to be used for making intradermal injections, FIG. 3 illustrates the drug container such assyringe 60 for use with theneedle assembly 20, and FIGS. 4-7 illustrated theintradermal delivery device 80 of the present invention for making intradermal injections. Intradermal injections include administering substances such as drugs, vaccines and the like into the skin of an animal such as a human. - The
needle assembly 20 includes ahub 22 that supports aneedle 24. Thelimiter 26 receives at least a portion of thehub 22 so that thelimiter 26 generally surrounds theneedle 24 as best seen in FIG. 2. - One
end 30 of thehub 22 is able to be secured to areceiver 32 of a syringe. A variety of syringe types can be used with a needle assembly designed according to this invention, with several examples being given below. The opposite end of thehub 22 preferably includesextensions 34 that are nestingly received againstabutment surfaces 36 within thelimiter 26. A plurality ofribs 38 preferably are provided on thelimiter 26 to provide structural integrity and to facilitate handling theneedle assembly 20. - By appropriately designing the size of the components, a distance d between a forward end or
tip 40 of theneedle 24 and a skinengaging surface 42 on thelimiter 26 can be tightly controlled. The distance d preferably is in a range from approximately 0.5 millimeters to approximately 3 millimeters. When theforward end 40 of theneedle 24 extends beyond the skin engaging surface 42 a distance within that range, an intradermal injection is ensured because the needle is unable to penetrate any further than the typical dermis layer of an animal. Typical tissue layers include an epidermis between 50 and 100 micrometers, a dermis layer between 2 and 3 mm then subcutaneous tissue followed by muscle tissue. - As can be best seen in FIG. 2, the
limiter 26 includes anopening 44 through which theforward end 40 of theneedle 24 protrudes. The dimensional relationship between the opening 44 and theneedle 40 can be controlled depending on the needs of a particular situation. In the illustrated embodiment, the skinengaging surface 42 is generally planar and continuous and provides a stable placement of theneedle assembly 20 against an animal's skin. Although not specifically illustrated, it may be advantageous to have the skin engaging surface be slightly concave or convex in order to facilitate stretching or gathering the animal's skin in the vicinity of theneedle tip 40 to facilitate making an injection. Additionally, theribs 38 may be extended beyond theskin engaging surface 42 to further facilitate manipulating the skin in the vicinity where the injection is to be given. - Regardless of the shape or contour of the
skin engaging surface 42, the preferred embodiment includes enough of a surface area that contacts the skin to facilitate stabilizing the injector relative to the animal's skin. In the most preferred arrangement, theskin engaging surface 42 facilitates maintaining the injector in a generally perpendicular orientation relative to the skin surface. - It is important to note that although FIGS. 1 and 2 illustrate a two-piece assembly where the
hub 22 is made separate from thelimiter 26, this invention is not limited to such an arrangement. Forming thehub 22 andlimiter 26 integrally from a single piece of plastic material is an alternative to the example shown in FIGS. 1 and 2. Additionally, it is possible to adhesively or otherwise secure thehub 22 to thelimiter 26 in the position illustrated in FIG. 2 so that theneedle assembly 20 becomes a single piece unit upon assembly. - Having a
hub 22 andlimiter 26 provides the advantage of making an intradermal needle practical to manufacture. The preferred needle size is a small gauge hypodermic needle, commonly known as a 30 gauge or 31 gauge needle. Having such a small diameter needle presents a challenge to make a needle short enough to prevent undue penetration beyond the dermis layer of an animal. Thelimiter 26 and thehub 22 facilitate utilizing aneedle 24 that has an overall length that is much greater than the effective length of the needle, which penetrates the individual's tissue during an injection. With a needle assembly designed according to this invention, manufacturing is enhanced because larger length needles can be handled during the manufacturing and assembly processes while still obtaining the advantages of having a short needle for purposes of completing an intradermal injection. - FIG. 3 illustrates a
needle assembly 20 secured to a drug container such as asyringe 60. A generallycylindrical syringe body 62 can be made of plastic or glass as is known in the art. Thesyringe body 62 provides areservoir 64 for containing a substance to be administered during an injection. Aplunger 66 has amanual activation flange 68 at one end with astopper 70 at an opposite end as known in the art. Manual movement of theplunger 66 through thereservoir 64 forces the substance within thereservoir 64 out of theend 40 of the needle as desired. - The
hub 22 can be secured to thesyringe body 62 in a variety of known manners. In one example, an interference fit is provided between the interior of thehub 22 and the exterior of theoutlet port portion 72 of thesyringe body 62. In another example, a conventional luer fit arrangement is provided to secure thehub 22 on the end of thesyringe 60. As can be appreciated from FIG. 3, a needle assembly designed according to this invention is readily adaptable to a wide variety of conventional syringe styles. - FIGS. 4 and 5 illustrate an alternative embodiment of an
intradermal delivery device 80 that includes a syringe made from two sheets of thermoplastic material. The syringe includes abody portion 82 that is generally flat and surrounds areservoir 84. Anoutlet port 86 allows fluid substance within thereservoir 84 to be communicated out of the reservoir to administer an injection. The syringe body preferably is formed using a thermoforming process as is known in the art. - A
receiver 90 includes a generallycylindrical neck portion 92 that preferably is secured to theoutlet port 86 using a heating or welding process as known in the art. Aflange 94 preferably rests against thebody portion 82 of the syringe to provide structural integrity. Anextension 96 extends away from theflange 94 in a direction opposite from thecylindrical portion 92. Theneedle assembly 20 preferably is received within theextension 96 as shown in FIG. 5. - The
receiver 90 preferably supports a sealingmembrane 100 that closes off theoutlet port 86 so that the syringe can be prefilled. Theneedle assembly 20 preferably includes aback end 102 of the needle that penetrates the sealingmembrane 100 when thehub 22 is received within theextension 96. - The side walls of the
reservoir 84 preferably are squeezed between a thumb and index finger so that the side walls collapse towards each other and the substance within thereservoir 84 is expelled through the opening in theforward end 40 of theneedle 24. In the embodiment of FIGS. 4 and 5, thehub 22 andlimiter 26 preferably are integrally molded as a single piece of plastic material. A snap fit arrangement secures thehub 22 within theextension 96 of thereceiver 90. Another alternative is illustrated in FIGS. 6 and 7. In this embodiment, thehub 22 is molded separately from thelimiter 26′, which is integrated with theextension 96. A difference between the embodiments of FIGS. 6 and 7 compared to that of FIGS. 4 and 5 includes anelongated extension 96 so that the side wall of theextension 96 provides theskin engaging surface 42′ of thelimiter 26′. In this embodiment, the limiter is supported by the syringe body. By appropriately choosing the dimensions of theneedle 24 and the length of theextension 96, the desired distant d between theskin engaging surface 42 and theneedle tip 40 can be achieved. - FIG. 7 also illustrates a
needle shield 110, which preferably is provided on thehub 22 andneedle 24. Theneedle shield 110 facilitates inserting thehub 22 within thereceiver 90 until thehub 22 is appropriately received within theextension 96 so that theintradermal delivery device 80 is ready for use. Theneedle shield 110 can be discarded after thehub 22 is in position. Alternatively, theneedle shield 110 can be replaced over theneedle 24 after an injection is complete to avoid the possibility for a needle stick while handling theintradermal delivery device 80 after it has been used. - Although the
shield 110 is only shown in FIG. 7, it preferably is utilized with the embodiments of FIGS. 4-7. - This invention provides an intradermal needle injector that is adaptable to be used with a variety of syringe types. Therefore, this invention provides the significant advantage of facilitating manufacture and assembly of intradermal needles on a mass production scale in an economical fashion.
- Operation and Use
- Having described the preferred embodiments of the
intradermal delivery device 80 of the present, including theneedle assembly 20 anddrug container 60, its operation and use is described below. - Use of the delivery device to administer substances such as drugs, vaccines and the like into the intradermal layer is significantly easier than with a traditional syringe and needle. Using a traditional syringe and needle is technique-dependent and requires considerable skill to develop an acceptable skin wheal. In particular, the needle must be carefully guided at a shallow angle under the skin while maintaining correct orientation of the needle bevel. In contrast, with a prefilled intradermal delivery device of the present invention, the user simply presses the device perpendicularly on to the skin and injects the substance. The depth of penetration of the needle is mechanically limited to the intradermal space. In this way, there is no need orient the needle bevel during injection. Orienting the device, particularly the needle, perpendicularly to the skin, as well as stability while injecting the substance, is facilitated by the design of the device.
- Referring now to FIG. 8, an example method of filling devices designed according to this invention is schematically illustrated in flow chart format. When the device includes a syringe of the style illustrated in FIG. 3, the following basic procedure is useful for prefilling the syringes with a desired substance.
- A supply of syringe barrels200 includes the desired form of syringe, such as those illustrated and discussed above. A locally controlled
environment 202 preferably is maintained in a known manner. The locally controlledenvironment 202 preferably is situated to immediately accept the syringes without requiring any intermediate cleaning or sterilizing steps between thesupply 200 and theenvironment 202. - In one example, the syringe barrels are washed with air at204 to remove any particulates from the syringes. The syringes preferably are then coated at 206 with a lubricant such as a lubricating silicone oil on the inner surface. The lubricant facilitates moving the
stopper 70 andplunger rod 66 through the syringe during actual use of the device. - The end of syringes that eventually will
needle assembly 20 may be capped with a tip cap within theenvironment 202. In one example, tip caps are supplied at 208. The tip caps are air washed at 210. The cleaned tip caps and syringe barrels are conveyed to anassembly device 212 where the tip caps are secured onto the syringes. The syringe barrel assemblies are then conveyed to afilling station 214 to be filled with the desired substance. - Once filled as desired, the
stoppers 70 are inserted into the open end of the syringes at 220. Prior to inserting thestoppers 70, they preferably are assembled with theplunger rods 66 at 222 and lubricated at 224 with a conventional lubricant in a known manner. The assembled, filled syringes preferably are inspected at 226 for defects and discharged from the locally controlled environment. - The syringes typically will be sterilized at230 and packaged at 232 into individual packages or into bulk packaging depending on the needs of a particular situation. Suitable sterilization techniques are known and will be chosen by those skilled in the art depending on the needs of a particular situation or to accommodate the properties of a given substance. Sterilizing a device designed according to this invention can be completed before or after packaging.
- Variations of the filling steps are within the scope of this invention. For example, the stopper can be inserted first, then fill the syringe, followed by applying a tip cap. Additionally, when the device includes a syringe body of the type shown in FIGS. 4 and 5, for example, the filling operation obviously does not include insertion of a stopper nor the lubrication steps described above. Instead, appropriate filling techniques that are known are utilized.
- The actual insertion of the desired substance into the syringe body can be accomplished in any of several known manners. Example filling techniques are disclosed in U.S. Pat. Nos. 5,620,425 to Hefferman et al.; 5,597,530 to Smith et al.; 5,537,042 to DeHaen; 5,531,255 to Vacca; 5,519,984 to Veussink et al.; 5,373,684 to Veussink et al.; 5,265,154 to Liebert et al.; 5,287,983 to Liebert et al.; and 4,718,463 to Jurgens, Jr. et al., each of which is incorporated by reference into this specification.
- The description given above provides example implementations of this invention. Variations and modifications may become apparent to those skilled in the art that do not necessarily depart from the basis of this invention. The scope of legal protection given to this invention can only be determined by studying the following claims.
Claims (37)
1. A hypodermic needle assembly for use in making intradermal injections, comprising:
a hub portion that is able to be attached to a drug container;
a needle supported by the hub portion, the needle having a hollow body with a forward end extending away from the hub portion; and
a limiter portion that surrounds the needle and extends away from the hub portion toward the forward end of the needle, the limiter portion having a skin engaging surface that is adapted to be received against skin of an animal to receive an intradermal injection, the needle forward end extending beyond the skin engaging surface a selected distance such that the limiter portion limits an amount that the needle is able to penetrate through the skin of an animal.
2. The assembly of , wherein the hub portion and the limiter portion are integrally formed as a single piece made from a plastic material.
claim 1
3. The assembly of , wherein the hub portion and the limiter portion are formed as separate pieces.
claim 1
4. The assembly of , wherein the limiter portion includes an inner cavity that receives at least a portion of the hub portion and the inner cavity includes an abutment surface that engages corresponding structure on the hub portion to thereby limit the amount that the needle forward end extends beyond the skin engaging surface.
claim 3
5. The assembly of , wherein the limiter portion is integrally formed as part of the syringe and the hub portion is received within the limiter portion.
claim 3
6. The assembly of , wherein the skin engaging surface surrounds the needle, and has a thickness defined between an inner diameter and an outer diameter and wherein the inner diameter is at least five times greater than an outside diameter of the needle.
claim 5
7. The assembly of , wherein the skin engaging surface is generally circular.
claim 6
8. The assembly of , wherein the skin engaging surface includes a central opening that is slightly larger than an outside dimension of the needle and the skin engaging surface is continuous.
claim 1
9. The assembly of , wherein the skin engaging surface is generally flat and extends through a plane that is generally perpendicular to an axis of the needle.
claim 1
10. The needle assembly of , wherein the selected distance that the forward end of the needle extends beyond the skin engaging surface is fixed.
claim 1
11. The assembly of , wherein the selected distance is in the range from approximately 0.5 mm to approximately 3 mm.
claim 1
12. The assembly of , wherein the skin engaging surface includes a contact surface area that is large enough to stabilize the assembly in a desired orientation relative to the skin.
claim 1
13. The assembly of , wherein the desired orientation is generally perpendicular to the skin.
claim 12
14. The assembly of , wherein the drug container is a syringe and the animal is human.
claim 1
15. An intradermal delivery device for use in making intradermal injections, comprising:
a drug container having a reservoir adapted to contain a selected substance and an outlet port that allows the substance to exit the reservoir during an injection;
a needle in fluid communication with the outlet port, the needle having a forward end that is adapted to penetrate an the skin of an animal; and
a limiter that surrounds the needle and has a skin engaging surface that is adapted to be placed against the skin of the animal to receive an intradermal injection, the needle forward end extending away from the skin engaging surface a selected distance such that the limiter limits an amount that the needle forward end penetrates the skin.
16. The device of , wherein the drug container is a syringe including a generally hollow, cylindrical body portion and a plunger that is received within the reservoir, the plunger being selectively movable within the reservoir to cause the substance to be forced out of the outlet port during an injection.
claim 15
17. The device of , including a hub portion that supports the needle and the hub portion is selectively secured to the drug container near the outlet port.
claim 15
18. The device of , wherein the drug container is a syringe includes a generally flat body portion that at least partially surrounds the reservoir, the body portion and the reservoir are made from two sheets of thermoplastic material such that side walls of the reservoir are selectively deflected toward each other to expel a substance from the reservoir during an injection.
claim 15
19. The device of , including a hub that supports the needle and is selectively secured to the syringe near the outlet port and a receiver adjacent the outlet port that is generally circular and the hub is completely received within the receiver and wherein the limiter is integrally formed with the receiver such that the limiter is permanently supported by the body portion adjacent the outlet port.
claim 18
20. The device of , wherein the skin engaging surface surrounds the needle, and has a thickness defined between an inner diameter and an outer diameter and wherein the inner diameter is at least five times greater than an outside diameter of the needle.
claim 19
21. The device of , wherein the skin engaging surface is generally circular.
claim 20
22. The device of , wherein the needle forward end extends away from the hub in a first direction and a needle back end extends away from the hub in a second direction, and including a sealing membrane that closes off the outlet port and wherein the needle back end pierces the sealing membrane when the hub is received by the receiver.
claim 19
23. The device of , including a hub that supports the needle and is selectively secured to the syringe near the outlet port and a receiver adjacent the outlet port that is generally circular and the hub is completely received within the receiver and wherein the limiter is formed separately from the receiver and is at least partially received by the receiver.
claim 18
24. The device of , wherein the limiter and the hub are integrally formed into a single piece structure.
claim 23
25. The device of , wherein the needle has a length and wherein the selected distance is much less than the needle length.
claim 15
26. The device of , wherein the selected distance is fixed and is in the range from approximately 0.5 mm to approximately 3 mm.
claim 25
27. The device of , wherein the skin engaging surface is generally flat and extends through a plane that is generally perpendicular to an axis of the needle.
claim 15
28. The device of , wherein the skin engaging surface includes a central opening that is slightly larger than an outside dimension of the needle and the skin engaging surface is continuous.
claim 15
29. The device of , wherein the skin engaging surface includes a contact surface area that is large enough to stabilize the assembly in a desired orientation relative to the skin.
claim 15
30. The device of , wherein the desired orientation is generally perpendicular to the skin.
claim 15
31. The device of , wherein the drug container is prefilled with a substance.
claim 15
32. A method of intradermally injecting at least one substance such as a drug, vaccine or the like into the skin, comprising the steps of:
pressing a needle perpendicularly to the skin of the animal to receive an injection, said needle in fluid communication with an outlet port of a drug container having a reservoir adapted to contain a selected substance and the outlet port allows the substance to exit the reservoir during an intradermal injection;
injecting the substance into the skin of the animal with the depth of penetration of the needle being limited to the intradermal space by a limiter that surrounds the needle and has a skin engaging surface that is adapted to be placed against the skin of the animal and a forward end of the needle extending away from the skin engaging surface a selected distance such that the limiter limits an amount that the needle forward end penetrates the skin of the animal.
33. The method of , wherein the step of pressing the needle perpendicularly to the skin of the animal includes orienting the needle perpendicularly to the skin.
claim 32
34. The method of , wherein the step of injecting the substance includes moving a plunger that is received within the reservoir, with the plunger being selectively movable within the reservoir to cause the substance to be forced out of the outlet port during the injection.
claim 32
35. The method of , wherein the step of injecting the substance into the skin of the animal includes deflecting at least two sheets of thermoplastic material forming a generally flat body portion that at least partially surrounds the reservoir toward each other to expel the substance from the reservoir during an injection.
claim 32
36. The method of , further comprising the step of filling the drug container with the substance to be intradermally injected.
claim 32
37. The method of , wherein said drug container is a syringe and said animal is human.
claim 32
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US09/825,395 US20010011171A1 (en) | 1999-10-14 | 2001-04-03 | Intradermal delivery device including a needle assembly |
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US09/417,671 US6494865B1 (en) | 1999-10-14 | 1999-10-14 | Intradermal delivery device including a needle assembly |
US09/825,395 US20010011171A1 (en) | 1999-10-14 | 2001-04-03 | Intradermal delivery device including a needle assembly |
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US14/576,347 Expired - Fee Related US9750897B2 (en) | 1999-10-14 | 2014-12-19 | Intradermal delivery device including a needle assembly |
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US14/576,347 Expired - Fee Related US9750897B2 (en) | 1999-10-14 | 2014-12-19 | Intradermal delivery device including a needle assembly |
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Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6629959B2 (en) | 1996-02-27 | 2003-10-07 | Injectimed, Inc. | Needle tip guard for percutaneous entry needles |
US20030199822A1 (en) * | 1999-10-14 | 2003-10-23 | Alchas Paul G. | Intradermal needle |
WO2007007128A1 (en) * | 2005-07-08 | 2007-01-18 | Cambridge Biostability Limited | Apparatus for administrating substances into a body |
US8267890B2 (en) | 2003-01-30 | 2012-09-18 | Becton, Dickinson And Company | Intradermal delivery device with contoured skin engaging surface geometry |
CN102791311A (en) * | 2010-02-01 | 2012-11-21 | 贝克顿·迪金森公司 | Low dose prefilled drug delivery device and method |
US8734390B2 (en) | 2009-09-30 | 2014-05-27 | Terumo Kabushiki Kaisha | Injection aid and medication syringe device |
US20150190589A1 (en) * | 2012-07-11 | 2015-07-09 | Novartis Ag | Injection device |
US9682198B2 (en) | 2003-08-28 | 2017-06-20 | Becton, Dickinson And Company | Intradermal injection device |
US20180318519A1 (en) * | 2015-11-16 | 2018-11-08 | Uniteko Co., Ltd. | Security cap assembly for syringe |
CN112349373A (en) * | 2020-11-03 | 2021-02-09 | 福州微猪信息科技有限公司 | Animal injection method |
Families Citing this family (203)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6835184B1 (en) | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
US20020193740A1 (en) | 1999-10-14 | 2002-12-19 | Alchas Paul G. | Method of intradermally injecting substances |
US6569143B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Method of intradermally injecting substances |
US6843781B2 (en) | 1999-10-14 | 2005-01-18 | Becton, Dickinson And Company | Intradermal needle |
US6569123B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Prefillable intradermal injector |
US6494865B1 (en) * | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
US6776776B2 (en) | 1999-10-14 | 2004-08-17 | Becton, Dickinson And Company | Prefillable intradermal delivery device |
US20020198509A1 (en) * | 1999-10-14 | 2002-12-26 | Mikszta John A. | Intradermal delivery of vaccines and gene therapeutic agents via microcannula |
US8465468B1 (en) * | 2000-06-29 | 2013-06-18 | Becton, Dickinson And Company | Intradermal delivery of substances |
US6595947B1 (en) * | 2000-05-22 | 2003-07-22 | Becton, Dickinson And Company | Topical delivery of vaccines |
US6547764B2 (en) * | 2000-05-31 | 2003-04-15 | Novo Nordisk A/S | Double pointed injection needle |
US20050181033A1 (en) * | 2000-06-29 | 2005-08-18 | Dekker John P.Iii | Method for delivering interferons to the intradermal compartment |
US20040175360A1 (en) * | 2000-06-29 | 2004-09-09 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
AU2005203015B2 (en) * | 2000-06-29 | 2008-03-13 | Becton, Dickinson And Company | Microneedle for delivering a substance into the dermis |
US20050008683A1 (en) * | 2000-06-29 | 2005-01-13 | Becton Dickinson And Company | Method for delivering interferons to the intradermal compartment |
AU2001280762A1 (en) * | 2000-08-02 | 2002-02-13 | Becton, Dickinson And Company | Pen needle and safety shield system |
GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
CA2438942A1 (en) * | 2001-02-23 | 2002-09-26 | Glaxosmithkline Biologicals S.A. | Influenza vaccine formulations for intradermal delivery |
CA2438960A1 (en) * | 2001-02-23 | 2002-09-06 | Glaxosmithkline Biologicals S.A. | Influenza vaccine formulations for intradermal delivery |
GB0109297D0 (en) * | 2001-04-12 | 2001-05-30 | Glaxosmithkline Biolog Sa | Vaccine |
EP1381423A1 (en) * | 2001-04-13 | 2004-01-21 | Becton, Dickinson and Company | Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption |
JP2004528896A (en) * | 2001-04-13 | 2004-09-24 | ベクトン・ディキンソン・アンド・カンパニー | How to inject a substance intradermally |
JP4883877B2 (en) * | 2001-04-13 | 2012-02-22 | ベクトン・ディキンソン・アンド・カンパニー | Intradermal needle |
EP1381344A4 (en) * | 2001-04-27 | 2008-06-11 | Glaxosmithkline Biolog Sa | Novel vaccine |
US20100221284A1 (en) | 2001-05-30 | 2010-09-02 | Saech-Sisches Serumwerk Dresden | Novel vaccine composition |
MY134424A (en) | 2001-05-30 | 2007-12-31 | Saechsisches Serumwerk | Stable influenza virus preparations with low or no amount of thiomersal |
JP2004532698A (en) | 2001-06-08 | 2004-10-28 | ベクトン・ディキンソン・アンド・カンパニー | Equipment for operation of needle or abrader arrays |
US20050010193A1 (en) * | 2002-05-06 | 2005-01-13 | Laurent Philippe E. | Novel methods for administration of drugs and devices useful thereof |
CA2460063C (en) | 2001-09-12 | 2010-07-20 | Becton, Dickinson And Company | Microneedle-based pen device for drug delivery and method for using same |
WO2003041763A2 (en) * | 2001-11-14 | 2003-05-22 | Medical Instill Technologies, Inc. | Intradermal delivery device and method |
ATE316395T1 (en) * | 2001-11-30 | 2006-02-15 | Novo Nordisk As | NEEDLE SAFETY DEVICE |
US20070005017A1 (en) * | 2002-02-04 | 2007-01-04 | Becton, Dickinson And Company | Intradermal delivery device with crenellated skin engaging surface geometry |
DK1478428T3 (en) * | 2002-02-04 | 2009-09-14 | Becton Dickinson Co | Device and method for delivering or withdrawing a substance through the skin |
JP3993169B2 (en) * | 2002-02-11 | 2007-10-17 | アンタレス・ファーマ・インコーポレーテッド | Intradermal syringe |
CN1655834A (en) * | 2002-05-06 | 2005-08-17 | 贝克顿·迪金森公司 | Method and device for controlling drug pharmacokinetics |
US20060264886A9 (en) * | 2002-05-06 | 2006-11-23 | Pettis Ronald J | Method for altering insulin pharmacokinetics |
US9486581B2 (en) * | 2002-09-11 | 2016-11-08 | Becton, Dickinson And Company | Injector device with force lock-out and injection rate limiting mechanisms |
AU2003278798A1 (en) | 2002-09-12 | 2004-04-30 | Children's Hospital Medical Center | Method and device for painless injection of medication |
US7252651B2 (en) * | 2003-01-07 | 2007-08-07 | Becton, Dickinson And Company | Disposable injection device |
ES2232269B1 (en) * | 2003-01-21 | 2006-03-01 | Grifols, S.A. | PROCEDURE FOR THE STERILE DOSAGE OF ROADS. |
ES2712469T3 (en) | 2003-01-30 | 2019-05-13 | Becton Dickinson Co | Support with security shield for a drug delivery device |
AU2004226323A1 (en) * | 2003-03-26 | 2004-10-14 | Becton, Dickinson And Company | Use of benzyl alcohol, and other phenolic preservatives to reduce pain during intradermal injection |
US20050123550A1 (en) * | 2003-05-12 | 2005-06-09 | Laurent Philippe E. | Molecules enhancing dermal delivery of influenza vaccines |
US7588774B2 (en) | 2003-05-12 | 2009-09-15 | Becton, Dickinson And Company | Molecules enhancing dermal delivery of influenza vaccines |
CA2529048A1 (en) * | 2003-06-13 | 2005-02-24 | Becton, Dickinson And Company | Improved intra-dermal delivery of biologically active agents |
US7998119B2 (en) * | 2003-11-18 | 2011-08-16 | Nano Pass Technologies Ltd. | System and method for delivering fluid into flexible biological barrier |
AU2004315509A1 (en) * | 2003-12-05 | 2005-08-18 | Becton, Dickinson And Company | Methods of enhancing immune response in the intradermal compartment and compounds useful in the methods |
US20060035905A1 (en) * | 2004-02-06 | 2006-02-16 | Becton, Dickinson And Company | Formulations of phosphodiesterase 5 inhibitors and methods of use |
US7896841B2 (en) | 2004-02-17 | 2011-03-01 | Children's Hospital Medical Center | Injection device for administering a vaccine |
US20050196380A1 (en) * | 2004-03-08 | 2005-09-08 | Mikszta John A. | Method for delivering therapeutic proteins to the intradermal compartment |
US7108679B2 (en) * | 2004-03-11 | 2006-09-19 | Becton, Dickinson And Company | Intradermal syringe and needle assembly |
CN100540086C (en) * | 2004-03-12 | 2009-09-16 | 新加坡科技研究局 | Be used for making the method and the mould of side-ported microneedles |
GB2414402B (en) * | 2004-05-28 | 2009-04-22 | Cilag Ag Int | Injection device |
GB2414775B (en) | 2004-05-28 | 2008-05-21 | Cilag Ag Int | Releasable coupling and injection device |
GB2414400B (en) * | 2004-05-28 | 2009-01-14 | Cilag Ag Int | Injection device |
EP2305295B1 (en) | 2004-09-22 | 2015-04-01 | GlaxoSmithKline Biologicals SA | Antibody composition for use in vaccination against staphylococcei |
US7617795B2 (en) * | 2004-10-13 | 2009-11-17 | Embrex, Inc. | Methods and apparatus for injecting and sampling material through avian egg membranes |
US8007466B2 (en) * | 2004-11-18 | 2011-08-30 | Nanopass Technologies Ltd. | System and method for delivering fluid into flexible biological barrier |
US20070292386A9 (en) * | 2004-12-02 | 2007-12-20 | Campbell Robert L | Vaccine formulations for intradermal delivery comprising adjuvants and antigenic agents |
US20060121055A1 (en) * | 2004-12-06 | 2006-06-08 | Becton, Dickinson And Company, Inc. | Compositions with enhanced immunogenicity |
EP3495009B1 (en) | 2005-01-24 | 2021-12-08 | Antares Pharma, Inc. | An injector with prefilled syringe |
US20070060904A1 (en) * | 2005-03-14 | 2007-03-15 | Becton, Dickinson And Company | Filling system and method for syringes with short needles |
TW200700078A (en) | 2005-03-23 | 2007-01-01 | Glaxosmithkline Biolog Sa | Novel use |
GB2425062B (en) | 2005-04-06 | 2010-07-21 | Cilag Ag Int | Injection device |
GB2424836B (en) * | 2005-04-06 | 2010-09-22 | Cilag Ag Int | Injection device (bayonet cap removal) |
GB2427826B (en) | 2005-04-06 | 2010-08-25 | Cilag Ag Int | Injection device comprising a locking mechanism associated with integrally formed biasing means |
US7645264B2 (en) * | 2005-04-11 | 2010-01-12 | Becton, Dickinson And Company | Injection device with secondary reservoir |
WO2006127962A2 (en) * | 2005-05-25 | 2006-11-30 | Becton, Dickinson And Comapny | Particulate formulations for intradermal delivery of biologically active agents |
DE602005018480D1 (en) | 2005-08-30 | 2010-02-04 | Cilag Gmbh Int | Needle device for a prefilled syringe |
US20110098656A1 (en) | 2005-09-27 | 2011-04-28 | Burnell Rosie L | Auto-injection device with needle protecting cap having outer and inner sleeves |
WO2007047539A2 (en) * | 2005-10-14 | 2007-04-26 | Medtronic, Inc. | Localized delivery to the lymphatic system |
EP1944051A4 (en) * | 2005-10-31 | 2009-09-02 | Terumo Corp | Puncture device, dosing device and puncture method |
US20070156096A1 (en) * | 2005-11-10 | 2007-07-05 | Terumo Kabushiki Kaisha | Puncture device |
US7611492B2 (en) * | 2005-11-10 | 2009-11-03 | Terumo Kabushiki Kaisha | Puncture device |
US7842008B2 (en) | 2005-11-21 | 2010-11-30 | Becton, Dickinson And Company | Intradermal delivery device |
TWI457133B (en) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | Novel composition |
GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
DK1973564T3 (en) | 2005-12-22 | 2017-01-16 | Glaxosmithkline Biologicals Sa | VACCINE COMPREHENSIVE STREPTOCOCCUS PNEUMONIAE-Capsule POLYSACCHARIDE CONJUGATE |
CA2536845C (en) * | 2006-02-16 | 2009-10-27 | Pka Softtouch Corp. | Drug delivery device |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
JP4828283B2 (en) * | 2006-03-30 | 2011-11-30 | テルモ株式会社 | Needleless injection device |
NZ595178A (en) | 2006-03-30 | 2013-03-28 | Glaxosmithkline Biolog Sa | Vaccine comprising Type 5 and Type 8 capsular polysaccharides from Staphyloccocus aureus |
WO2007131013A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Two-stage reconstituting injector |
GB2438590B (en) * | 2006-06-01 | 2011-02-09 | Cilag Gmbh Int | Injection device |
GB2438593B (en) | 2006-06-01 | 2011-03-30 | Cilag Gmbh Int | Injection device (cap removal feature) |
GB2438591B (en) | 2006-06-01 | 2011-07-13 | Cilag Gmbh Int | Injection device |
PT2422810E (en) | 2006-07-17 | 2014-12-03 | Glaxosmithkline Biolog Sa | Influenza vaccine |
EP2520168B1 (en) | 2006-07-21 | 2014-03-19 | California Institute of Technology | Targeted gene delivery for dendritic cell vaccination |
US7914489B1 (en) * | 2006-08-03 | 2011-03-29 | Univec International, Inc. | Safety syringe |
US20090326415A1 (en) * | 2006-08-28 | 2009-12-31 | Agency For Science ,Technology And Research | Microneedles and methods for fabricating microneedles |
JP2010503454A (en) * | 2006-09-18 | 2010-02-04 | エージェンシー フォー サイエンス、テクノロジー アンド リサーチ | Needle structure and method for fabricating the needle structure |
WO2008042814A2 (en) * | 2006-09-29 | 2008-04-10 | California Institute Of Technology | Mart-1 t cell receptors |
EP2433648A3 (en) | 2006-10-12 | 2012-04-04 | GlaxoSmithKline Biologicals S.A. | Vaccine comprising an oil in water emulsion adjuvant |
EA015817B1 (en) | 2006-10-12 | 2011-12-30 | Глаксосмитклайн Байолоджикалс С.А. | Immunogenic composition comprising an oil in water emulsion adjuvant |
US8002756B2 (en) * | 2006-12-08 | 2011-08-23 | Becton, Dickinson And Company | Method and apparatus for delivering a therapeutic substance through an injection port |
AR066405A1 (en) | 2007-04-20 | 2009-08-19 | Glaxosmithkline Biolog Sa | VACCINE |
JP5213950B2 (en) | 2007-04-23 | 2013-06-19 | エス・アイ・ディ・テクノロジーズ・リミテッド・ライアビリティ・カンパニー | Method and apparatus for intradermal injection |
US7751907B2 (en) | 2007-05-24 | 2010-07-06 | Smiths Medical Asd, Inc. | Expert system for insulin pump therapy |
PL2175881T3 (en) * | 2007-06-14 | 2012-12-31 | Crucell Switzerland Ag | Intradermal influenza vaccine |
EA201391788A1 (en) | 2007-06-26 | 2014-08-29 | Глаксосмитклайн Байолоджикалс С.А. | VACCINE CONTAINING CONJUGATES OF CAPSULAR POLYSACCHARIDES STREPTOCOCCUS PNEUMONIAE |
AU2008314485B9 (en) * | 2007-10-15 | 2015-02-26 | Jingang Medicine (Australia) Pty Ltd | Expression system for modulating an immune response |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
EP2257323B1 (en) | 2008-01-30 | 2019-05-29 | Becton Dickinson France | Dose dividing delivery device |
MX2010011412A (en) | 2008-04-16 | 2010-11-12 | Glaxosmithkline Biolog Sa | Vaccine. |
GB2461086B (en) * | 2008-06-19 | 2012-12-05 | Cilag Gmbh Int | Injection device |
GB2461085B (en) * | 2008-06-19 | 2012-08-29 | Cilag Gmbh Int | Injection device |
GB2461087B (en) * | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Injection device |
GB2461089B (en) * | 2008-06-19 | 2012-09-19 | Cilag Gmbh Int | Injection device |
GB2461084B (en) * | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Fluid transfer assembly |
CA2951841C (en) | 2008-07-18 | 2018-07-10 | Becton, Dickinson And Company | Dual chamber and gear pump assembly for a high pressure delivery system |
WO2010010488A1 (en) * | 2008-07-21 | 2010-01-28 | Wockhardt Research Centre | Device for attachment to a needle assembly to vary the length of the needle being exposed |
EP2318075B1 (en) | 2008-08-05 | 2019-05-22 | Antares Pharma, Inc. | Multiple dosage injector |
EP3960224A1 (en) * | 2008-08-15 | 2022-03-02 | Becton, Dickinson and Company | Safety pen needle assembly |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
EP2334234A4 (en) | 2008-09-19 | 2013-03-20 | Tandem Diabetes Care Inc | Solute concentration measurement device and related methods |
CN202044604U (en) | 2008-09-30 | 2011-11-23 | 泰尔茂株式会社 | Syringe needle and drug injection device |
JP5713913B2 (en) | 2008-11-07 | 2015-05-07 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | Syringe housing for easy drug injection |
CA2743904A1 (en) | 2008-11-17 | 2010-05-20 | The Regents Of The University Of Michigan | Cancer vaccine compositions and methods of using the same |
CN102307612B (en) | 2008-12-08 | 2015-01-07 | Sid技术有限责任公司 | Alignment of a needle in an intradermal injection device |
TWI449551B (en) | 2009-01-30 | 2014-08-21 | Terumo Corp | Injection needle assembly and drug injection device |
JP5732039B2 (en) | 2009-03-20 | 2015-06-10 | アンタレス・ファーマ・インコーポレーテッド | Hazardous drug injection system |
JP5270424B2 (en) * | 2009-03-30 | 2013-08-21 | テルモ株式会社 | Drug injection device and needle assembly |
CN102369034A (en) | 2009-03-30 | 2012-03-07 | 泰尔茂株式会社 | Syringe needle assembly and medicament injection device |
BRPI1016063B1 (en) * | 2009-05-28 | 2021-02-23 | Simcro Limited | skin holding means and injector |
JP2013500074A (en) | 2009-07-23 | 2013-01-07 | エスアイディー・テクノロジーズ・エルエルシー | Intradermal injection adapter |
DK2770061T3 (en) | 2009-07-24 | 2019-01-07 | Immune Design Corp | NON-INTEGRATING LENTIVIRUS VECTORS |
CA2921304C (en) | 2009-07-30 | 2018-06-05 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
GB0919117D0 (en) | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
GB201003920D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Method of treatment |
GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
US9283330B2 (en) | 2010-03-10 | 2016-03-15 | Terumo Kabushiki Kaisha | Injection needle assembly and drug injection apparatus |
US9381310B2 (en) | 2010-03-10 | 2016-07-05 | Terumo Kabushiki Kaisha | Injection needle assembly and drug injection apparatus |
ES2575546T3 (en) | 2010-03-12 | 2016-06-29 | Sid Technologies Llc | Set for use with a syringe |
JP2011206273A (en) | 2010-03-30 | 2011-10-20 | Terumo Corp | Injection needle assembly and medicine injection device |
CN102844064A (en) | 2010-03-31 | 2012-12-26 | 泰尔茂株式会社 | Prefilled syringe |
US9795658B2 (en) | 2010-04-20 | 2017-10-24 | Admedus Vaccines Pty Ltd | Expression system for modulating an immune response |
EP2589397A4 (en) | 2010-06-30 | 2013-11-27 | Terumo Corp | Drug injection apparatus and drug container |
US8512295B2 (en) | 2010-08-19 | 2013-08-20 | West Pharmaceutical Services, Inc. | Rigid needle shield |
WO2012051575A2 (en) | 2010-10-15 | 2012-04-19 | Iscience Interventional Corporation | Device for ocular access |
EP2489379B1 (en) | 2011-01-21 | 2020-09-23 | SID Technologies, LLC | Intradermal pen adapter |
GB201103836D0 (en) | 2011-03-07 | 2011-04-20 | Glaxosmithkline Biolog Sa | Conjugation process |
SG194733A1 (en) | 2011-05-17 | 2013-12-30 | Glaxosmithkline Biolog Sa | Vaccine against streptococcus pneumoniae |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
GB201120000D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
GB201119999D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
JP6276204B2 (en) | 2012-03-13 | 2018-02-07 | ベクトン ディキンソン フランス | Manufacturing method for miniaturized drug delivery devices |
GB201205189D0 (en) | 2012-03-23 | 2012-05-09 | Glaxosmithkline Biolog Sa | Novel medical use |
EA038702B1 (en) | 2012-03-30 | 2021-10-07 | Иммьюн Дизайн Корп. | Lentiviral vector particles having improved transduction efficiency for cells expressing dc sign |
US9950125B2 (en) | 2012-04-06 | 2018-04-24 | Antares Pharma, Inc. | Needle assisted jet injection administration of testosterone compositions |
CA2869479C (en) | 2012-04-09 | 2023-03-14 | Becton, Dickinson And Company | Injection mechanism utilizing a vial |
WO2013169804A1 (en) | 2012-05-07 | 2013-11-14 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
JP6067007B2 (en) | 2012-05-30 | 2017-01-25 | 三井化学株式会社 | Three-component adhesive mixing device and three-component adhesive kit |
US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
JP2015525794A (en) | 2012-08-06 | 2015-09-07 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | Method for eliciting an immune response against RSV and Bordetella pertussis in infants |
JP2016507305A (en) | 2013-02-11 | 2016-03-10 | アンタレス・ファーマ・インコーポレーテッド | Needle-assisted jet injection device with reduced trigger force |
US20140257204A1 (en) * | 2013-03-05 | 2014-09-11 | Stuart Robert Lessin | Apparatus for reconstituting and dispensing drugs for topical application |
JP6030803B2 (en) | 2013-03-11 | 2016-11-24 | アンタレス・ファーマ・インコーポレーテッド | Dose syringe with pinion system |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
US9474865B2 (en) | 2013-04-25 | 2016-10-25 | West Pharmaceutical Services, Inc. | Needle shield for disposable syringe with annular ring |
SG10201702674PA (en) | 2013-05-03 | 2017-06-29 | Clearside Biomedical Inc | Apparatus and methods for ocular injection |
GB2517896B (en) | 2013-06-11 | 2015-07-08 | Cilag Gmbh Int | Injection device |
GB2515032A (en) * | 2013-06-11 | 2014-12-17 | Cilag Gmbh Int | Guide for an injection device |
GB2515038A (en) | 2013-06-11 | 2014-12-17 | Cilag Gmbh Int | Injection device |
GB2515039B (en) | 2013-06-11 | 2015-05-27 | Cilag Gmbh Int | Injection Device |
US20160193322A1 (en) | 2013-08-05 | 2016-07-07 | Glaxosmithkline Biologicals S.A. | Combination immunogenic compositions |
JP6785157B2 (en) * | 2013-08-27 | 2020-11-18 | レプロ−メッド システムズ、インコーポレーテッド | How to choose a needle for subcutaneous treatment |
CN104436157A (en) | 2013-09-23 | 2015-03-25 | 恩金生物有限公司 | Influenza vaccine and therapy |
CA2951430A1 (en) | 2014-06-13 | 2015-12-17 | Glaxosmithkline Biologicals Sa | Immunogenic combinations |
KR102481455B1 (en) | 2014-06-30 | 2022-12-26 | 머독 칠드런스 리서치 인스티튜트 | Helicobacter therapeutic |
US20180015101A1 (en) | 2014-10-28 | 2018-01-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for antigen-specific tolerance |
CN107106789B (en) * | 2015-01-19 | 2021-06-25 | 株式会社Jms | Medical fluid extraction tip, fluid extraction nozzle, and injector assembly |
KR102507581B1 (en) * | 2015-01-19 | 2023-03-08 | 가부시끼가이샤 제이엠에스 | Medical body fluid injector |
EP3248634B1 (en) * | 2015-01-20 | 2021-10-27 | Terumo Kabushiki Kaisha | Injection needle assembly and injector provided therewith for injecting drug solution into upper layer of skin |
WO2016158141A1 (en) | 2015-03-27 | 2016-10-06 | テルモ株式会社 | Injection needle assembly and drug injection device |
GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
EP3738973A1 (en) | 2015-11-09 | 2020-11-18 | Immune Design Corp. | Compositions comprising lentiviral vectors expressing il-12 and methods of use thereof |
CA3004132A1 (en) | 2015-11-09 | 2017-05-18 | Immune Design Corp. | A retroviral vector for the administration and expression of replicon rna expressing heterologous nucleic acids |
US10828235B2 (en) | 2015-11-30 | 2020-11-10 | Becton, Dickinson And Company | Short injection length syringe |
KR20180083437A (en) | 2015-12-09 | 2018-07-20 | 애드메더스 백신스 피티와이 리미티드 | Immune modulating composition for treatment |
EA201891717A1 (en) | 2016-02-23 | 2019-02-28 | Иммьюн Дизайн Корп. | PREPARATIONS OF MULTI-GENOMIC RETROVIRAL VECTORS AND METHODS AND SYSTEMS FOR THEIR RECEPTION AND APPLICATION |
GB201603625D0 (en) | 2016-03-02 | 2016-04-13 | Glaxosmithkline Biolog Sa | Novel influenza antigens |
WO2017167768A1 (en) | 2016-03-28 | 2017-10-05 | Glaxosmithkline Biologicals S.A. | Novel vaccine composition |
JP2019514581A (en) | 2016-05-02 | 2019-06-06 | クリアサイド バイオメディカル,インコーポレイテッド | Systems and methods for ocular drug delivery |
CN105944223A (en) * | 2016-05-03 | 2016-09-21 | 遵义医学院 | Animal skull perforating administration apparatus |
GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
WO2018018082A1 (en) | 2016-07-26 | 2018-02-01 | The Australian National University | Immunostimulatory compositions and uses therefor |
CN110177527B (en) | 2016-08-12 | 2022-02-01 | 科尼尔赛德生物医学公司 | Device and method for adjusting insertion depth of needle for medicament delivery |
JP7246318B2 (en) | 2016-12-15 | 2023-03-27 | ピーケイエイ ソフトタッチ コーポレイション | Intradermal drug delivery device with locked post-dispensing configuration |
CN110087717A (en) * | 2016-12-16 | 2019-08-02 | 豪夫迈·罗氏有限公司 | Spacer for syringe |
WO2018148180A2 (en) | 2017-02-07 | 2018-08-16 | Immune Design Corp. | Materials and methods for identifying and treating cancer patients |
US10857343B2 (en) | 2017-04-06 | 2020-12-08 | Becton, Dickinson And Company | Medical devices with visual and tactile indicators |
USD835268S1 (en) * | 2017-04-06 | 2018-12-04 | Becton, Dickinson And Company | Syringe tip with indicator |
USD835269S1 (en) * | 2017-04-06 | 2018-12-04 | Becton, Dickinson And Company | Syringe tip with indicator |
WO2018237221A1 (en) | 2017-06-23 | 2018-12-27 | Nosocomial Vaccine Corporation | Immunogenic compositions |
CH714053A1 (en) | 2017-08-11 | 2019-02-15 | Pantec Ag | Administration device and method for producing such. |
GB201721582D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | S aureus antigens and immunogenic compositions |
GB201721576D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | Hla antigens and glycoconjugates thereof |
WO2023274860A1 (en) | 2021-06-28 | 2023-01-05 | Glaxosmithkline Biologicals Sa | Novel influenza antigens |
US20230233667A1 (en) | 2021-09-08 | 2023-07-27 | Affinivax, Inc. | Coronavirus vaccine |
WO2023110893A1 (en) * | 2021-12-15 | 2023-06-22 | Sanofi | Assembly for an injection device, injection device comprising such an assembly, medicament container for such an assembly, and method for producing such a medicament container |
Citations (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1274081A (en) * | 1917-05-10 | 1918-07-30 | Herman A Metz | Hypodermic needle. |
US1934046A (en) * | 1931-10-30 | 1933-11-07 | Demarchi Mario | Syringe for hypodermic medical injections |
US2559474A (en) * | 1950-03-09 | 1951-07-03 | Sonco Inc | Hypodermic and spinal syringe |
US2876770A (en) * | 1955-10-10 | 1959-03-10 | Raymond A White | Shielded hypodermic syringe |
US3073306A (en) * | 1958-09-03 | 1963-01-15 | Linder Fritz | Hypodermic syringe |
US3400715A (en) * | 1966-01-04 | 1968-09-10 | Halvard J. Pederson | Attachment for injection apparatus |
US4373526A (en) * | 1979-06-20 | 1983-02-15 | Lothar Kling | Device for injection syringe |
US4468223A (en) * | 1981-08-06 | 1984-08-28 | Terumo Kabushiki Kaisha | Syringe |
US4769003A (en) * | 1987-08-19 | 1988-09-06 | Keith Stamler | Wound irrigation splashback shield |
US4774948A (en) * | 1986-11-24 | 1988-10-04 | Markham Charles W | Marking and retraction needle having retrievable stylet |
US4834704A (en) * | 1988-04-13 | 1989-05-30 | Eaton Corporation | Injectable infusion pump apparatus for implanting long-term dispensing module and medication in an animal and method therefor |
US4874384A (en) * | 1987-07-13 | 1989-10-17 | International Medical Innovators, Inc. | Needle safety guard |
US4883573A (en) * | 1986-12-10 | 1989-11-28 | Basf Aktiengesellschaft | Removal of acid from cathodic electrocoating baths by electrodialysis |
US4898588A (en) * | 1988-10-17 | 1990-02-06 | Roberts Christopher W | Hypodermic syringe splatter shield |
US4955871A (en) * | 1987-04-29 | 1990-09-11 | Path | Single-use disposable syringe |
US4978344A (en) * | 1988-08-11 | 1990-12-18 | Dombrowski Mitchell P | Needle and catheter assembly |
US5137516A (en) * | 1989-11-28 | 1992-08-11 | Glaxo Group Limited | Triggered application device for medicament to be more descriptive of the invention |
US5141496A (en) * | 1988-11-03 | 1992-08-25 | Tino Dalto | Spring impelled syringe guide with skin penetration depth adjustment |
US5147328A (en) * | 1989-06-02 | 1992-09-15 | Becton, Dickinson And Company | Syringe assembly |
US5190521A (en) * | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
US5195526A (en) * | 1988-03-11 | 1993-03-23 | Michelson Gary K | Spinal marker needle |
US5222949A (en) * | 1991-07-23 | 1993-06-29 | Intermed, Inc. | Flexible, noncollapsible catheter tube with hard and soft regions |
US5241969A (en) * | 1992-06-10 | 1993-09-07 | Carson Jay W | Controlled and safe fine needle aspiration device |
US5417662A (en) * | 1991-09-13 | 1995-05-23 | Pharmacia Ab | Injection needle arrangement |
US5505694A (en) * | 1990-08-22 | 1996-04-09 | Tcnl Technologies, Inc. | Apparatus and method for raising a skin wheal |
US5578014A (en) * | 1992-04-29 | 1996-11-26 | Erez; Uri | Skin piercing devices for medical use |
US5672883A (en) * | 1994-03-16 | 1997-09-30 | Syncor International Corporation | Container and method for transporting a syringe containing radioactive material |
US5679355A (en) * | 1992-04-07 | 1997-10-21 | Proteus Molecular Design Limited | Vaccines containing non-ionic surfactant vesicles |
US5848991A (en) * | 1990-12-13 | 1998-12-15 | Elan Medical Technologies Limited Athlone, Co. | Intradermal drug delivery device and method for intradermal delivery of drugs |
US5873856A (en) * | 1995-06-22 | 1999-02-23 | Pharmacia Ab | Limited depth penetration needle housing |
US6099504A (en) * | 1997-10-22 | 2000-08-08 | Elan Corporation, Plc | Pre-filled injection delivery device |
US6146361A (en) * | 1996-09-26 | 2000-11-14 | Becton Dickinson And Company | Medication delivery pen having a 31 gauge needle |
US6200291B1 (en) * | 1998-01-08 | 2001-03-13 | Antonio Di Pietro | Device for controlling the penetration depth of a needle, for application to an injection syringe |
US6203529B1 (en) * | 1997-11-19 | 2001-03-20 | B D Medico | Needle arrangement |
US6210369B1 (en) * | 1997-12-16 | 2001-04-03 | Meridian Medical Technologies Inc. | Automatic injector |
US20010012925A1 (en) * | 1999-10-14 | 2001-08-09 | Alchas Paul G. | Intradermal delivery device including a needle assembly |
US20020038111A1 (en) * | 1999-10-14 | 2002-03-28 | Alchas Paul G. | Method of intradermally injecting substances |
US20020068909A1 (en) * | 1999-10-14 | 2002-06-06 | Alchas Paul G. | Intradermal needle |
US20020193740A1 (en) * | 1999-10-14 | 2002-12-19 | Alchas Paul G. | Method of intradermally injecting substances |
US20030014018A1 (en) * | 2000-08-02 | 2003-01-16 | Lucio Giambattista | Pen needle and safety shield system |
US20030199822A1 (en) * | 1999-10-14 | 2003-10-23 | Alchas Paul G. | Intradermal needle |
Family Cites Families (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1453309A (en) * | 1921-05-24 | 1923-05-01 | Jr Jacob A Eberly | Hypodermic syringe |
US3179107A (en) * | 1962-11-21 | 1965-04-20 | Becton Dickinson Co | Hypodermic unit with an improved mounting for a replaceable needle assembly |
US3406687A (en) * | 1966-06-23 | 1968-10-22 | Resiflex Lab | Guide and positioning means for a needle |
US3737973A (en) * | 1970-10-20 | 1973-06-12 | Becton Dickinson Co | Method and device for assembling a stopper to a syringe barrel |
US3934590A (en) * | 1974-11-21 | 1976-01-27 | Campagna Gary J | Ocular positioning droplet dispensing device |
US4060073A (en) | 1976-03-19 | 1977-11-29 | Medi-Ray, Inc. | Syringe shield |
US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
JPS5745946U (en) * | 1980-09-01 | 1982-03-13 | ||
CA1231016A (en) | 1983-01-23 | 1988-01-05 | Amir Porat | Syringe |
US4481001A (en) | 1983-05-26 | 1984-11-06 | Collagen Corporation | Human skin model for intradermal injection demonstration or training |
US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
US4718463A (en) | 1985-12-20 | 1988-01-12 | Mallinckrodt, Inc. | Method of producing prefilled sterile plastic syringes |
US4778453A (en) * | 1986-04-07 | 1988-10-18 | Icu Medical, Inc. | Medical device |
CA1283827C (en) | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
FR2612401A1 (en) | 1987-03-16 | 1988-09-23 | Denance Raymond | Stabiliser end-piece for hypodermic needle comprising a means acting as a prop for regulating the penetration as a function of attack of the needle in the skin |
US4816024A (en) * | 1987-04-13 | 1989-03-28 | Icu Medical, Inc. | Medical device |
US4883473A (en) | 1987-04-29 | 1989-11-28 | Path | Single use injection device |
US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
GB2206794A (en) | 1987-07-14 | 1989-01-18 | Richard Kiteley Power | Syringe |
US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
EP0423864A1 (en) | 1989-10-16 | 1991-04-24 | Duphar International Research B.V | Training device for an automatic injector |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
US6090790A (en) * | 1989-12-14 | 2000-07-18 | Eriksson; Elof | Gene delivery by microneedle injection |
US5437647A (en) | 1990-05-09 | 1995-08-01 | Safety Syringes, Inc. | Disposable self-shielding aspirating syringe |
US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
US5331954A (en) | 1990-12-21 | 1994-07-26 | Novo Nordisk A/S | Device for nasal delivery of liquid medications |
DE4127887C1 (en) | 1991-08-22 | 1993-01-28 | Manfred Prof. Dr. 8520 Erlangen De Herbst | Subcutaneous medicine delivery device preventing needle from exceeding required depth - comprises tube attached with needle free to move on wedge shaped needle holder with needle penetration holes of different depth |
GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
US5248300A (en) * | 1991-12-16 | 1993-09-28 | Abbott Laboratories | Ambulatory infusion system with spring-pressurized reservoir |
US5207983A (en) | 1992-01-29 | 1993-05-04 | Sterling Winthrop Inc. | Method of terminal steam sterilization |
US5256154A (en) | 1992-01-31 | 1993-10-26 | Sterling Winthrop, Inc. | Pre-filled plastic syringes and containers and method of terminal sterilization thereof |
US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
US5431155A (en) | 1992-06-03 | 1995-07-11 | Elettro Plastica S.P.A. | Single-dose nasal dispenser for atomized liquid drugs |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
US5820872A (en) * | 1992-11-18 | 1998-10-13 | Yale University | Methods and compositions for improving the effectiveness of X-irradiation therapy for the treatment of an internal solid tumor |
US5373684A (en) | 1992-12-14 | 1994-12-20 | Mallinckrodt Medical, Inc. | Process and apparatus used in producing prefilled, sterile delivery devices |
IE68890B1 (en) | 1993-04-08 | 1996-07-24 | Elan Med Tech | Intradermal delivery device |
US5540664A (en) | 1993-05-27 | 1996-07-30 | Washington Biotech Corporation | Reloadable automatic or manual emergency injection system |
AU7085594A (en) | 1993-07-02 | 1995-01-24 | Ji Hoon Park | Syringe |
US5364387A (en) * | 1993-08-02 | 1994-11-15 | Becton, Dickinson And Company | Drug access assembly for vials and ampules |
US5569089A (en) | 1993-10-28 | 1996-10-29 | Signorelli; Richard L. | Universal joint construction |
US5620425A (en) | 1993-11-03 | 1997-04-15 | Bracco International B.V. | Method for the preparation of pre-filled plastic syringes |
FR2715071B1 (en) | 1994-01-17 | 1996-03-01 | Aguettant Lab | Automatic drug injector. |
US5514107A (en) | 1994-02-10 | 1996-05-07 | Habley Medical Technology Corporation | Safety syringe adapter for cartridge-needle unit |
WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
US5368578A (en) | 1994-03-10 | 1994-11-29 | Sterling Winthrop Inc. | Hypodermic syringe holder |
FR2718357B1 (en) | 1994-04-06 | 1997-10-03 | Defarges Alain Moreau | Improvements made to a needleless jet injection device. |
GB9412301D0 (en) | 1994-06-17 | 1994-08-10 | Safe T Ltd | Hollow-needle drugs etc applicators |
US5496286A (en) | 1994-08-17 | 1996-03-05 | Sterling Winthrop | Hypodermic syringe holder with disposable body |
US5597530A (en) | 1994-08-18 | 1997-01-28 | Abbott Laboratories | Process for prefilling and terminally sterilizing syringes |
US5582598A (en) | 1994-09-19 | 1996-12-10 | Becton Dickinson And Company | Medication delivery pen with variable increment dose scale |
JP3208525B2 (en) | 1995-01-05 | 2001-09-17 | 電気化学工業株式会社 | Sodium hyaluronate solution injection and container for injection |
US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
AU696439B2 (en) | 1995-03-07 | 1998-09-10 | Eli Lilly And Company | Recyclable medication dispensing device |
US5519984A (en) | 1995-03-16 | 1996-05-28 | Mallinckrodt Medical, Inc. | Methods for packaging a pressure or vacuum sensitive product |
US6090077A (en) | 1995-05-11 | 2000-07-18 | Shaw; Thomas J. | Syringe plunger assembly and barrel |
IT1275428B (en) | 1995-05-16 | 1997-08-07 | Bracco Spa | PROCESS FOR THE PRODUCTION OF PRE-FILLED SYRINGES WITHOUT RESIDUAL GAS BUBBLES |
US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
DE19518810A1 (en) | 1995-05-26 | 1996-11-28 | Bayer Ag | Nasal applicator |
US5899879A (en) | 1995-12-19 | 1999-05-04 | Genesis Medical Technologies, Inc. | Spring-actuated needleless injector |
US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
SE9601348D0 (en) * | 1996-04-10 | 1996-04-10 | Pharmacia Ab | Improved containers for parenteral fluids |
GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
WO1997042883A1 (en) * | 1996-05-17 | 1997-11-20 | Mercury Diagnostics, Inc. | Disposable element for use in a body fluid sampling device |
WO1998001172A1 (en) | 1996-07-05 | 1998-01-15 | Disetronic Licensing Ag | Injection device for injection of liquid |
US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
DE19740187C1 (en) | 1997-09-12 | 1999-04-15 | Disetronic Licensing Ag | Dosing unit, e.g. for medicines |
US5944700A (en) | 1997-09-26 | 1999-08-31 | Becton, Dickinson And Company | Adjustable injection length pen needle |
US6482176B1 (en) | 1997-11-27 | 2002-11-19 | Disetronic Licensing Ag | Method and device for controlling the introduction depth of an injection needle |
US5961495A (en) | 1998-02-20 | 1999-10-05 | Becton, Dickinson And Company | Medication delivery pen having a priming mechanism |
US6090082A (en) | 1998-02-23 | 2000-07-18 | Becton, Dickinson And Company | Vial retainer interface to a medication delivery pen |
CA2229522A1 (en) * | 1998-04-15 | 1999-10-15 | Thomas Randall Inkpen | Needle aid |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
JP4118399B2 (en) | 1998-07-21 | 2008-07-16 | テルモ株式会社 | Puncture adjusting tool for injection needle and injection needle assembly including the same |
US6112743A (en) | 1998-09-04 | 2000-09-05 | Wolfe Tory Medical, Inc. | Connector for syringe and atomizer and the like |
TW373505U (en) | 1999-01-28 | 1999-11-01 | Perfect Medical Industry Co Ltd | Improved structure for the safety syringe barrel |
US6036675A (en) | 1999-02-03 | 2000-03-14 | Specialized Health Products, Inc. | Safety sterile cartride unit apparatus and methods |
WO2000048662A1 (en) * | 1999-02-16 | 2000-08-24 | Prismedical Corporation | Single dose delivery device |
US6319230B1 (en) * | 1999-05-07 | 2001-11-20 | Scimed Life Systems, Inc. | Lateral needle injection apparatus and method |
US6623457B1 (en) * | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
DK1478428T3 (en) * | 2002-02-04 | 2009-09-14 | Becton Dickinson Co | Device and method for delivering or withdrawing a substance through the skin |
-
1999
- 1999-10-14 US US09/417,671 patent/US6494865B1/en not_active Expired - Lifetime
-
2000
- 2000-10-02 AT AT00121570T patent/ATE326994T1/en active
- 2000-10-02 PT PT00121570T patent/PT1092444E/en unknown
- 2000-10-02 EP EP00121570A patent/EP1092444B1/en not_active Expired - Lifetime
- 2000-10-02 DK DK00121570T patent/DK1092444T3/en active
- 2000-10-02 DE DE60028151T patent/DE60028151T2/en not_active Expired - Lifetime
- 2000-10-02 ES ES00121570T patent/ES2265318T3/en not_active Expired - Lifetime
- 2000-10-09 AU AU64093/00A patent/AU782456B2/en not_active Expired
- 2000-10-16 JP JP2000315938A patent/JP2001137343A/en active Pending
-
2001
- 2001-04-03 US US09/825,395 patent/US20010011171A1/en not_active Abandoned
- 2001-04-03 US US09/825,017 patent/US20010012925A1/en not_active Abandoned
-
2006
- 2006-08-11 CY CY20061101130T patent/CY1107497T1/en unknown
- 2006-12-25 JP JP2006348390A patent/JP5283331B2/en not_active Expired - Lifetime
-
2007
- 2007-10-11 US US11/871,012 patent/US20080033395A1/en not_active Abandoned
-
2013
- 2013-11-15 US US14/081,412 patent/US20140074064A1/en not_active Abandoned
-
2014
- 2014-12-19 US US14/576,347 patent/US9750897B2/en not_active Expired - Fee Related
Patent Citations (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1274081A (en) * | 1917-05-10 | 1918-07-30 | Herman A Metz | Hypodermic needle. |
US1934046A (en) * | 1931-10-30 | 1933-11-07 | Demarchi Mario | Syringe for hypodermic medical injections |
US2559474A (en) * | 1950-03-09 | 1951-07-03 | Sonco Inc | Hypodermic and spinal syringe |
US2876770A (en) * | 1955-10-10 | 1959-03-10 | Raymond A White | Shielded hypodermic syringe |
US3073306A (en) * | 1958-09-03 | 1963-01-15 | Linder Fritz | Hypodermic syringe |
US3400715A (en) * | 1966-01-04 | 1968-09-10 | Halvard J. Pederson | Attachment for injection apparatus |
US4373526A (en) * | 1979-06-20 | 1983-02-15 | Lothar Kling | Device for injection syringe |
US4468223A (en) * | 1981-08-06 | 1984-08-28 | Terumo Kabushiki Kaisha | Syringe |
US4774948A (en) * | 1986-11-24 | 1988-10-04 | Markham Charles W | Marking and retraction needle having retrievable stylet |
US4883573A (en) * | 1986-12-10 | 1989-11-28 | Basf Aktiengesellschaft | Removal of acid from cathodic electrocoating baths by electrodialysis |
US4955871A (en) * | 1987-04-29 | 1990-09-11 | Path | Single-use disposable syringe |
US4874384A (en) * | 1987-07-13 | 1989-10-17 | International Medical Innovators, Inc. | Needle safety guard |
US4769003A (en) * | 1987-08-19 | 1988-09-06 | Keith Stamler | Wound irrigation splashback shield |
US5195526A (en) * | 1988-03-11 | 1993-03-23 | Michelson Gary K | Spinal marker needle |
US4834704A (en) * | 1988-04-13 | 1989-05-30 | Eaton Corporation | Injectable infusion pump apparatus for implanting long-term dispensing module and medication in an animal and method therefor |
US4978344A (en) * | 1988-08-11 | 1990-12-18 | Dombrowski Mitchell P | Needle and catheter assembly |
US4898588A (en) * | 1988-10-17 | 1990-02-06 | Roberts Christopher W | Hypodermic syringe splatter shield |
US5141496A (en) * | 1988-11-03 | 1992-08-25 | Tino Dalto | Spring impelled syringe guide with skin penetration depth adjustment |
US5147328A (en) * | 1989-06-02 | 1992-09-15 | Becton, Dickinson And Company | Syringe assembly |
US5137516A (en) * | 1989-11-28 | 1992-08-11 | Glaxo Group Limited | Triggered application device for medicament to be more descriptive of the invention |
US5190521A (en) * | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
US5505694A (en) * | 1990-08-22 | 1996-04-09 | Tcnl Technologies, Inc. | Apparatus and method for raising a skin wheal |
US5848991A (en) * | 1990-12-13 | 1998-12-15 | Elan Medical Technologies Limited Athlone, Co. | Intradermal drug delivery device and method for intradermal delivery of drugs |
US5222949A (en) * | 1991-07-23 | 1993-06-29 | Intermed, Inc. | Flexible, noncollapsible catheter tube with hard and soft regions |
US5417662A (en) * | 1991-09-13 | 1995-05-23 | Pharmacia Ab | Injection needle arrangement |
US5679355A (en) * | 1992-04-07 | 1997-10-21 | Proteus Molecular Design Limited | Vaccines containing non-ionic surfactant vesicles |
US5578014A (en) * | 1992-04-29 | 1996-11-26 | Erez; Uri | Skin piercing devices for medical use |
US5921963A (en) * | 1992-04-29 | 1999-07-13 | Mali-Tech Ltd. | Skin piercing devices for medical use |
US5241969A (en) * | 1992-06-10 | 1993-09-07 | Carson Jay W | Controlled and safe fine needle aspiration device |
US5672883A (en) * | 1994-03-16 | 1997-09-30 | Syncor International Corporation | Container and method for transporting a syringe containing radioactive material |
US5873856A (en) * | 1995-06-22 | 1999-02-23 | Pharmacia Ab | Limited depth penetration needle housing |
US6146361A (en) * | 1996-09-26 | 2000-11-14 | Becton Dickinson And Company | Medication delivery pen having a 31 gauge needle |
US6099504A (en) * | 1997-10-22 | 2000-08-08 | Elan Corporation, Plc | Pre-filled injection delivery device |
US6203529B1 (en) * | 1997-11-19 | 2001-03-20 | B D Medico | Needle arrangement |
US6210369B1 (en) * | 1997-12-16 | 2001-04-03 | Meridian Medical Technologies Inc. | Automatic injector |
US6200291B1 (en) * | 1998-01-08 | 2001-03-13 | Antonio Di Pietro | Device for controlling the penetration depth of a needle, for application to an injection syringe |
US20010012925A1 (en) * | 1999-10-14 | 2001-08-09 | Alchas Paul G. | Intradermal delivery device including a needle assembly |
US20020038111A1 (en) * | 1999-10-14 | 2002-03-28 | Alchas Paul G. | Method of intradermally injecting substances |
US20020068909A1 (en) * | 1999-10-14 | 2002-06-06 | Alchas Paul G. | Intradermal needle |
US6494865B1 (en) * | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
US20020193740A1 (en) * | 1999-10-14 | 2002-12-19 | Alchas Paul G. | Method of intradermally injecting substances |
US20030199822A1 (en) * | 1999-10-14 | 2003-10-23 | Alchas Paul G. | Intradermal needle |
US20050113753A1 (en) * | 1999-10-14 | 2005-05-26 | Alchas Paul G. | Intradermal needle |
US20030014018A1 (en) * | 2000-08-02 | 2003-01-16 | Lucio Giambattista | Pen needle and safety shield system |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6629959B2 (en) | 1996-02-27 | 2003-10-07 | Injectimed, Inc. | Needle tip guard for percutaneous entry needles |
US20030199822A1 (en) * | 1999-10-14 | 2003-10-23 | Alchas Paul G. | Intradermal needle |
US7241275B2 (en) | 1999-10-14 | 2007-07-10 | Becton, Dickinson And Company | Intradermal needle |
US8267890B2 (en) | 2003-01-30 | 2012-09-18 | Becton, Dickinson And Company | Intradermal delivery device with contoured skin engaging surface geometry |
US9682198B2 (en) | 2003-08-28 | 2017-06-20 | Becton, Dickinson And Company | Intradermal injection device |
WO2007007128A1 (en) * | 2005-07-08 | 2007-01-18 | Cambridge Biostability Limited | Apparatus for administrating substances into a body |
US8734390B2 (en) | 2009-09-30 | 2014-05-27 | Terumo Kabushiki Kaisha | Injection aid and medication syringe device |
CN102791311A (en) * | 2010-02-01 | 2012-11-21 | 贝克顿·迪金森公司 | Low dose prefilled drug delivery device and method |
US20150190589A1 (en) * | 2012-07-11 | 2015-07-09 | Novartis Ag | Injection device |
US20180318519A1 (en) * | 2015-11-16 | 2018-11-08 | Uniteko Co., Ltd. | Security cap assembly for syringe |
CN112349373A (en) * | 2020-11-03 | 2021-02-09 | 福州微猪信息科技有限公司 | Animal injection method |
Also Published As
Publication number | Publication date |
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US20010012925A1 (en) | 2001-08-09 |
JP2007130488A (en) | 2007-05-31 |
JP2001137343A (en) | 2001-05-22 |
EP1092444A1 (en) | 2001-04-18 |
CY1107497T1 (en) | 2013-03-13 |
US20140074064A1 (en) | 2014-03-13 |
EP1092444B1 (en) | 2006-05-24 |
ES2265318T3 (en) | 2007-02-16 |
AU782456B2 (en) | 2005-07-28 |
US20080033395A1 (en) | 2008-02-07 |
ATE326994T1 (en) | 2006-06-15 |
DE60028151T2 (en) | 2007-03-29 |
AU6409300A (en) | 2001-04-26 |
US20150231338A1 (en) | 2015-08-20 |
DK1092444T3 (en) | 2006-09-25 |
JP5283331B2 (en) | 2013-09-04 |
US9750897B2 (en) | 2017-09-05 |
DE60028151D1 (en) | 2006-06-29 |
US6494865B1 (en) | 2002-12-17 |
PT1092444E (en) | 2006-08-31 |
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