TWM471276U - Collagen particle structure for improving skin condition - Google Patents

Collagen particle structure for improving skin condition Download PDF

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Publication number
TWM471276U
TWM471276U TW102207553U TW102207553U TWM471276U TW M471276 U TWM471276 U TW M471276U TW 102207553 U TW102207553 U TW 102207553U TW 102207553 U TW102207553 U TW 102207553U TW M471276 U TWM471276 U TW M471276U
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Taiwan
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collagen
skin condition
improving skin
microparticle structure
layer
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TW102207553U
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Chinese (zh)
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Yung-Hsiang Lin
Yi-Jun Liu
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Tci Co Ltd
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Description

改善肌膚狀態的膠原蛋白微粒結構 Collagen particle structure that improves skin condition

本創作涉及一種膠原蛋白微粒結構,特別涉及能有效改善肌膚狀態的膠原蛋白微粒結構。 The present invention relates to a collagen particle structure, and more particularly to a collagen particle structure capable of effectively improving skin condition.

膠原蛋白(collagen)是一種生物性高分子物質,是一種白色、不透明、無支鏈的纖維性蛋白質。它可以補充皮膚各層所需的營養,使皮膚中膠原活性增強,有滋潤皮膚,延緩衰老、美容、消皺、養發等功效。 Collagen (collagen) is a biological polymer substance, a white, opaque, unbranched fibrous protein. It can replenish the nutrients needed for each layer of the skin, enhance the collagen activity in the skin, moisturize the skin, delay aging, beauty, wrinkle, and hair growth.

膠原蛋白主要分佈在哺乳動物的結締組織中,對動物和人體皮膚、血管、骨骼、筋腱、牙齒和軟骨的形成都十分重要,是這些結締組織的主要物質基礎。人體蛋白質中有三分之一是膠原蛋白,成年人體中大約有3公斤的膠原蛋白,因此,我們可以毫不誇張的說,膠原蛋白是一切動物的生命支架。 Collagen is mainly distributed in the connective tissue of mammals and is important for the formation of animal and human skin, blood vessels, bones, tendons, teeth and cartilage. It is the main material basis of these connective tissues. One-third of human protein is collagen, and about 3 kilograms of collagen in adults. Therefore, we can say without exaggeration that collagen is the life support of all animals.

隨著年齡的增長,膠原蛋白會逐漸的流失。女性在20歲時膠原蛋白已經開始老化、流失,含量逐年下降,25歲則進入流失的高峰期,40歲時,含量不到18歲時的一半,老年人臉上溝溝坎坎的皺紋,正是因為膠原 蛋白和水分流失,造成皮膚塌陷。膠原蛋白的流失導致支撐皮膚的膠原肽鍵和彈力網斷裂,其螺旋網狀結構隨即被破壞,皮膚組織被氧化、萎縮、塌陷,肌膚就會出現乾燥、皺紋、鬆弛無彈性等衰老現象。所以,要延緩衰老必須要補充膠原蛋白。 As you age, collagen will gradually lose. At the age of 20, women's collagen has begun to age and lose, and its content has been declining year by year. At the age of 25, it has reached the peak of loss. At the age of 40, it is less than half of the age of 18 years old. The wrinkles of the gully on the face of the elderly are precisely because collagen Protein and water loss, causing skin to collapse. The loss of collagen leads to the breakage of collagen peptide bonds and elastic nets supporting the skin, and the spiral network structure is destroyed immediately. The skin tissue is oxidized, atrophied and collapsed, and the skin will appear dry, wrinkles, slack and inelasticity and other aging phenomena. Therefore, to delay aging, you must add collagen.

目前,常見補充膠原蛋白方式有口服含膠原蛋白的食物和直接皮下注射。 At present, the common way to supplement collagen is oral collagen-containing food and direct subcutaneous injection.

直接皮下注射,主要用於填充深的皺紋,皮膚損傷造成的缺損(如青春痘疤)和修補臉形的缺陷等。其效果立竿見影,但注射到皮膚內的膠原蛋白會被人體逐漸吸收,因此其功效只能維持半年至一年,而且少數人群可能會出現過敏、感染等副作用。 Direct subcutaneous injection, mainly used to fill deep wrinkles, defects caused by skin damage (such as acne scars) and repair of face defects. The effect is immediate, but the collagen injected into the skin will be gradually absorbed by the body, so its efficacy can only last for six months to one year, and a few people may have side effects such as allergies and infections.

由此可知,上述補充膠原蛋白的方式仍存在不夠方便的缺陷,為了改善缺點,創作人協同研發團隊,共同努力尋找解決方式,針對膠原蛋白的特性,並進行一連串的人體吸收試驗,最後,終於研究出本創作一種改善肌膚狀態的膠原蛋白微粒結構。 It can be seen that the above-mentioned method of supplementing collagen still has inconveniences. In order to improve the shortcomings, the creators work together with the R&D team to find a solution, aim at the characteristics of collagen, and carry out a series of human absorption tests. Finally, finally This study has developed a collagen particle structure that improves skin condition.

為解決上述問題,本創作的目的是提供一種改善肌膚狀態的膠原蛋白微粒結構,包含:一含膠原蛋白的活性核心層;一甜味劑層,其包覆於所述活性核心層的外部;以及一保護層,其包覆於所述甜味劑層的外 部。其中所述含膠原蛋白的活性核心層易於被腸道吸收,且經過實驗證明,膠原蛋白的活性核心層在吸收後,能夠補充皮膚中膠原蛋白、促使皮膚保持年輕,同時預防皮膚老化、增強代謝角質、加強消除皺紋、進而恢復皮膚彈性與光澤、達到保濕功能。 In order to solve the above problems, the object of the present invention is to provide a collagen microparticle structure for improving skin condition, comprising: a collagen-containing active core layer; and a sweetener layer coated on the outside of the active core layer; And a protective layer covering the outside of the sweetener layer unit. The active core layer containing collagen is easily absorbed by the intestine, and it has been experimentally proved that the active core layer of collagen can replenish collagen in the skin, promote skin youthfulness, and prevent skin aging and metabolism. It exfoliates, strengthens wrinkles, restores skin elasticity and shine, and achieves moisturizing function.

在本創作的實施例中,所述活性核心層進一步包含有維生素C、β-胡蘿蔔素、檸檬酸中的一種或任意組合。 In an embodiment of the present invention, the active core layer further comprises one or any combination of vitamin C, beta-carotene, citric acid.

所述膠原蛋白為單一來源的膠原蛋白或任兩種來源的膠原蛋白的組合。所述甜味劑層所採用的甜味劑選自由葡萄糖、果糖、蔗糖、麥芽糖、赤蘚糖醇、蔗糖素、澱粉糖和乳糖所組成的群組。依食用者喜好增添不同的成分,口感富有多樣性。 The collagen is a single source of collagen or a combination of any two sources of collagen. The sweetener used in the sweetener layer is selected from the group consisting of glucose, fructose, sucrose, maltose, erythritol, sucralose, starch sugar, and lactose. Different ingredients are added according to the preferences of the consumer, and the taste is rich and varied.

在本創作的一實施例中,所述保護層為選自可供人體食用的明膠、阿拉伯膠、果膠、玉米糖膠、黃耆膠所組成的群組。 In an embodiment of the present invention, the protective layer is selected from the group consisting of gelatin, gum arabic, pectin, corn candy, and tragacanth for human consumption.

所述保護層進一步包含一賦形劑,其中該賦形劑選自由調味劑、增甜劑、防腐劑、抗氧化劑、螯合劑、滲透劑、潤滑劑、著色劑、以及結合劑所組成的群組。 The protective layer further comprises an excipient, wherein the excipient is selected from the group consisting of a flavoring agent, a sweetener, a preservative, an antioxidant, a chelating agent, a penetrating agent, a lubricant, a coloring agent, and a binding agent. group.

所述甜味劑厚度為0.01-0.05mm,所述保護層厚度為0.01-0.05mm。 The sweetener has a thickness of 0.01-0.05 mm, and the protective layer has a thickness of 0.01-0.05 mm.

在本創作的較佳實施例中,所述活性核心層表面粗 糙。這樣,可以增加該層表面積。表面積增加,有助於增加活性核心層與甜味劑層之間的附著力,同時,在進入人體後,還可增加活性核心層內含的效性成份在體內釋放的速度。另外,所述保護層之表面也粗糙。 In a preferred embodiment of the present invention, the active core layer has a rough surface rough. In this way, the surface area of the layer can be increased. The increased surface area helps to increase the adhesion between the active core layer and the sweetener layer, and at the same time, upon entering the human body, it also increases the rate of release of the active ingredient contained in the active core layer in the body. In addition, the surface of the protective layer is also rough.

在本創作的另一實施例中,本創作的改善肌膚狀態的膠原蛋白微粒結構為功能性食品,且為粉劑包、飲品、膠囊或糖片(壓片糖果)的形式。 In another embodiment of the present invention, the collagen particle structure of the present invention which improves skin condition is a functional food and is in the form of a powder package, a drink, a capsule or a candy tablet (tablet candy).

在本創作的進一步實施中,所述保護層的外表面還包含一防潮層。該防潮層可以阻斷空氣中水氣附在膠原蛋白微粒結構表面,避免微粒吸濕而潮解。該防潮層可以使得膠原蛋白微粒結構易於長期保存。 In a further implementation of the present invention, the outer surface of the protective layer further comprises a moisture barrier layer. The moisture barrier layer blocks the moisture in the air from adhering to the surface of the collagen particle structure to prevent the particles from absorbing moisture and deliquescent. The moisture barrier layer makes the collagen particle structure easy to store for a long time.

由於本創作的微粒結構中含有膠原蛋白,通過服用本創作的這種膠原蛋白微粒結構可以達到補充皮膚中膠原蛋白、使皮膚保持年輕、預防皮膚老化、代謝角質、消除皺紋、恢復皮膚彈性與光澤、促進保濕的功效,並且還具有方便使用者補充膠原蛋白的優點。 Since the particle structure of the present invention contains collagen, by taking the collagen particle structure of the present invention, it is possible to replenish collagen in the skin, keep the skin young, prevent skin aging, metabolize keratin, eliminate wrinkles, restore skin elasticity and luster. It promotes the moisturizing effect and also has the advantage of facilitating the user to supplement the collagen.

〔本創作〕 [this creation]

10‧‧‧保護層 10‧‧‧Protective layer

20‧‧‧甜味劑層 20‧‧‧Sweetener layer

30‧‧‧活性核心層 30‧‧‧Active core layer

40‧‧‧防潮層 40‧‧‧ moisture barrier

31‧‧‧第一膠囊殼體 31‧‧‧First capsule housing

311‧‧‧第一套合口 311‧‧‧ first set of joints

312‧‧‧第一鋸齒表面 312‧‧‧First serrated surface

32‧‧‧第二膠囊殼體 32‧‧‧Second capsule housing

321‧‧‧第二套合口 321‧‧‧Second set of joints

322‧‧‧第二鋸齒表面 322‧‧‧Second serrated surface

33‧‧‧容置空間 33‧‧‧ accommodating space

1‧‧‧膠原蛋白微粒結構 1‧‧‧Collagen particle structure

2‧‧‧口服錠 2‧‧‧ Oral ingot

4‧‧‧保健食品袋體 4‧‧‧Health food bag

第1圖 為本創作一實施例的結構立體示意圖;第2圖 為受測者的膚質緊實度變化曲線圖;第3圖為受測者的膚質保水性變化曲線圖;第4圖為受測者的膚質淨彈力變化曲線圖; 第5圖為中空圓形錠型的口服錠的立體部份剖面圖;第6A圖至第6D圖分別是本創作的三角形錠型態樣、圓形錠型態樣、四角形錠型態樣、蜆狀錠型態樣的口服錠的示意圖;第7圖為膠原蛋白微粒結構置於膠囊中的結構分解圖;第8圖為膠原蛋白微粒結構自袋體內傾倒至杯體的示意圖;第9圖為增加防潮層的實施例的結構剖面圖。 1 is a perspective view showing the structure of an embodiment of the present invention; FIG. 2 is a graph showing changes in skin firmness of a subject; FIG. 3 is a graph showing changes in skin water retention of a subject; FIG. The curve of the net elasticity of the skin of the subject; Figure 5 is a three-dimensional partial cross-sectional view of an oral ingot of a hollow circular ingot type; Figures 6A to 6D are respectively a triangular ingot type, a circular ingot type, a quadrangular ingot type, Schematic diagram of an oral ingot in the shape of a scorpion; Figure 7 is a structural exploded view of the collagen microparticle structure in a capsule; Figure 8 is a schematic view of the collagen microparticle structure pouring from the inside of the bag to the cup; A structural cross-sectional view of an embodiment for increasing the moisture barrier.

為了能夠更清楚地描述本創作所提出之一種改善肌膚狀態的膠原蛋白微粒結構,以下將配合圖式,詳盡說明本創作之較佳實施例。 In order to more clearly describe the collagen particle structure proposed by the present invention for improving the skin condition, a preferred embodiment of the present invention will be described in detail below with reference to the drawings.

請參考第1圖,係本創作一實施例的結構立體示意圖。如第1圖所示,本創作的一實施例的改善肌膚狀態的膠原蛋白微粒結構,包括一保護層10、一甜味劑層20和一活性核心層30。甜味劑層20包覆在活性核心層30的外部,保護層10包覆在甜味劑層20的外部。活性核心層30中含有膠原蛋白。該保護層10選自可供人體食用的明膠、阿拉伯膠、果膠、玉米糖膠、黃耆膠或其他等膠體物質。該甜味劑層20選自由葡萄 糖、果糖、蔗糖、麥芽糖、赤蘚糖醇、蔗糖素、澱粉糖和乳糖所組成的群組。 Please refer to FIG. 1 , which is a perspective view showing the structure of an embodiment of the present invention. As shown in Fig. 1, the collagen microparticle structure for improving the skin condition of an embodiment of the present invention comprises a protective layer 10, a sweetener layer 20 and an active core layer 30. The sweetener layer 20 is coated on the outside of the active core layer 30, and the protective layer 10 is coated on the outside of the sweetener layer 20. The active core layer 30 contains collagen. The protective layer 10 is selected from the group consisting of gelatin, gum arabic, pectin, corn candy, tragacanth or other colloidal substances which are available for human consumption. The sweetener layer 20 is selected from the group consisting of grapes A group consisting of sugar, fructose, sucrose, maltose, erythritol, sucralose, starch sugar, and lactose.

其中,甜味劑層20的厚度為0.01-0.05mm;保護層10的厚度為0.01-0.05mm。為增加活性核心層30的表面積,該活性核心層30表面可形成粗糙表面。活性核心層30表面積的增加,有助於增加活性核心層與甜味劑層之間的附著力,同時,在進入人體後,還可增加活性核心層內含的效性成份在體內釋放的速度。另外,保護層10之表面也可形成粗糙表面。 Wherein, the thickness of the sweetener layer 20 is 0.01-0.05 mm; and the thickness of the protective layer 10 is 0.01-0.05 mm. To increase the surface area of the active core layer 30, the surface of the active core layer 30 can form a rough surface. The increase in surface area of the active core layer 30 helps to increase the adhesion between the active core layer and the sweetener layer, and at the same time, after entering the human body, the rate of release of the active ingredient contained in the active core layer in the body can be increased. . In addition, the surface of the protective layer 10 may also form a rough surface.

具體地來說,活性核心層30內包括有單一來源的膠原蛋白或任兩種來源的膠原蛋白的組合,還包括有維生素C、β-胡蘿蔔素、檸檬酸或其他調味劑。膠原蛋白的種類有魚膠原蛋白,豬膠原蛋白或牛膠原蛋白。 Specifically, the active core layer 30 includes a single source of collagen or a combination of any two sources of collagen, and also includes vitamin C, beta-carotene, citric acid or other flavoring agents. The types of collagen are fish collagen, porcine collagen or bovine collagen.

本創作的保護層還可進一步包括食品上可接受的賦形劑,此賦形劑選自由調味劑、增甜劑、防腐劑、抗氧化劑、螯合劑、滲透劑、潤滑劑、著色劑、以及結合劑所組成的群組中。 The protective layer of the present invention may further comprise a food acceptable excipient selected from the group consisting of flavoring agents, sweeteners, preservatives, antioxidants, chelating agents, penetrants, lubricants, colorants, and A group of binders.

本創作於實施使用時,可用於水中形成溶液後飲用,或直接經由口腔攝食。當溶於水中形成溶液後,於50ml的溶液中,含品質百分比的膠原蛋白10%,其餘包含維生素C 0.4%,ß胡蘿蔔素0.01%,果糖9%,檸檬酸0.96%,濃縮果汁19%,剩下為水。當其進入人 體,人體可直接吸收高活性的膠原蛋白的天然活性成分,該活性物質系天然物質,非化學合成藥物,有助於人體皮膚的保養。 When the present application is used, it can be used to form a solution in water, or directly ingested through the mouth. When dissolved in water to form a solution, in a 50ml solution, containing 10% of the percentage of collagen, the rest contains vitamin C 0.4%, ß carotene 0.01%, fructose 9%, citric acid 0.96%, concentrated juice 19%, The rest is water. When it enters people Body, the body can directly absorb the natural active ingredients of high-activity collagen, the active substance is a natural substance, non-chemical synthetic drugs, which contribute to the maintenance of human skin.

由皮膚生化測試結果證實本創作膠原蛋白微粒結構具有改善肌膚狀態的功效。茲對實施方式詳盡說明如下: The skin biochemical test results confirmed that the collagen particle structure of the present invention has an effect of improving skin condition. The implementation is described in detail as follows:

採用德國Courage-Khazaka Electronic Gmbh公司的膚質檢測儀MPA580機型作為測試儀器。膚質檢測儀MPA580內建的精密探測裝置使膚質的檢測更為精確,同時外接其它Courage-Khazaka制的精密膚質檢測系統而成為完整的膚質檢測平臺。膚質檢測儀MPA580依外接各式的機能性探測儀能針對膚質的紅、黑色素,表皮水分量、膚質緊實度及淨彈力做測量。 The skin quality tester MPA580 model of Courage-Khazaka Electronic Gmbh of Germany was used as a test instrument. The skin detector MPA580's built-in precision detection device makes the skin quality more accurate, and it is a complete skin quality detection platform by connecting other Courage-Khazaka precision skin detection systems. The skin quality tester MPA580 can measure the red, melanin, skin moisture, skin firmness and net elasticity of the skin according to various external functional detectors.

本創作的膠原蛋白微粒機構所含的膠原蛋白及維生素C,能改善及修復肌膚狀態。 The collagen and vitamin C contained in the collagen microparticle mechanism of this creation can improve and repair the skin condition.

為了驗證本創作的結構功效,係進行實驗,該實驗通過7位平均年齡25歲的上班族進行試驗,試驗者每人每日飲用50ml,持續飲用四周,並每週進行一次膚質緊實度、淨彈力、保濕度及膚質放大攝影的檢測。 In order to verify the structural efficacy of this creation, an experiment was conducted. The experiment was conducted by 7 office workers with an average age of 25 years. The tester drank 50 ml per person per day for 4 weeks and had a skin firmness per week. , net elasticity, moisturizing and skin quality magnification photography.

請參考第2圖以及表1,其中,第2圖係受測者的膚質緊實度變化曲線圖,表1則係資料顯示飲用膠原蛋白微粒結構後膚質緊實度的效果變化。使用第0-4 周的膚質緊實度的檢測結果如表1和第2圖所示,七位測試者的膚質緊實度均隨飲用的時間長度而改變,平均膚質緊實度上升5.93%。 Please refer to Fig. 2 and Table 1, in which Fig. 2 is a graph showing the skin firmness of the subject, and Table 1 shows the effect of the skin firmness after drinking the collagen microparticle structure. Use 0-4 The results of the skin firmness test for the week are shown in Tables 1 and 2. The skin firmness of the seven testers varied with the length of the drink, and the average skin firmness increased by 5.93%.

請參考第3圖以及表2,其中,第2圖係受測者的膚質保水性變化曲線圖,表2則係資料顯示飲用膠原蛋白微粒結構後膚質保水性的效果變化。使用第0-4周的膚質保水性的檢測結果如表2和第3圖所示,七位測試者的膚質保水性均隨引用的時間長度而改變,平均膚質保水性上升48.23%。 Please refer to Fig. 3 and Table 2, in which Fig. 2 is a graph showing the skin water retention curve of the subject, and Table 2 shows the effect of skin water retention after drinking the collagen particle structure. The results of the skin water retention test using Week 0-4 are shown in Table 2 and Figure 3. The skin water retention of the seven test subjects varied with the length of time cited, and the average skin water retention increased by 48.23%. .

請參考第4圖以及表3,其中,第4圖係受測者的膚質淨彈力變化曲線圖,表3則係資料顯示飲用膠原蛋白微粒結構後膚質淨彈力的效果變化。使用第0-4周的膚質淨彈力的檢測結果如表3和第4圖所示,七位測試者的膚質淨彈力均隨引用的時間長度而改變,平均膚質淨彈力上升6.47%。 Please refer to Figure 4 and Table 3, where Figure 4 is a plot of the net elasticity of the skin of the subject, and Table 3 shows the effect of the net elasticity of the skin after drinking the collagen particle structure. The results of using the net elasticity of skin quality from week 0-4 are shown in Tables 3 and 4. The net elasticity of the skin of the seven testers varied with the length of time quoted, and the average skin elasticity increased by 6.47%. .

從上述可以看出,本創作的含有膠原蛋白及維生素C的膠原蛋白顆粒具有改善及修護肌膚狀態的功效。 As can be seen from the above, the collagen particles containing collagen and vitamin C of the present invention have the effect of improving and repairing the skin condition.

本創作的改善肌膚狀態的膠原蛋白微粒結構中的活性核心層除了採用上述組合成分外,還可以採用下列組合成分: In addition to the above-mentioned combination components, the active core layer in the collagen particle structure of the present invention for improving skin condition can also adopt the following combination components:

(1)活性核心層30僅包含膠原蛋白,不添加其它任何成分。如此,可製作成膠原蛋白純粉。 (1) The active core layer 30 contains only collagen, and no other ingredients are added. In this way, a pure collagen powder can be produced.

(2)活性核心層30僅包含膠原蛋白和赤蘚糖醇,其中含品質百分比的膠原蛋白為99%-97%%、赤蘚糖醇 1-3%2%。這製作成另一種膠原蛋白微粒粉。 (2) The active core layer 30 contains only collagen and erythritol, and the percentage of collagen containing 99%-97% by weight of erythritol 1-3% 2%. This is made into another collagen particle powder.

(3)活性核心層30總品質為3.5-10g,包含膠原蛋白和其他原料如維生素C、玻尿酸和Q10等。其中膠原蛋白含量為3-5g。將此膠原蛋白微粒結構可搭配其他添加劑或香料等,溶於水中形成溶液後,以適當水量溶解形成50ml的膠原蛋白飲品。 (3) The active core layer 30 has a total quality of 3.5-10 g and contains collagen and other raw materials such as vitamin C, hyaluronic acid and Q10. The collagen content is 3-5 g. The collagen microparticle structure can be combined with other additives or spices, dissolved in water to form a solution, and dissolved in an appropriate amount of water to form a 50 ml collagen drink.

(4)活性核心層30總品質為13.5-20g,包含膠原蛋白、百合萃取物等其他原料,其中膠原蛋白含量為10-13g。將此膠原蛋白微粒結構可搭配其他添加劑或香料等,用於水中形成溶液後,以適當水量溶解形成50ml的膠原蛋白飲品。 (4) The active core layer 30 has a total mass of 13.5-20 g and contains other raw materials such as collagen and lily extract, wherein the collagen content is 10-13 g. The collagen microparticle structure can be combined with other additives or fragrances to form a solution in water, and then dissolved in an appropriate amount of water to form a 50 ml collagen drink.

(5)活性核心層30包含膠原蛋白和果汁調味粉,其中膠原蛋白占50-80%品質百分比。這製作成一種膠原蛋白調味粉。 (5) The active core layer 30 comprises collagen and juice flavoring powder, wherein the collagen accounts for 50-80% by mass. This is made into a collagen flavoring powder.

此外,本創作人還提供另一實施例,該保護層10為一腸溶膜衣,該腸溶膜衣需至腸道之環境中才會溶解,並將核心功效層的活性成分釋放,使活性成分免於胃酸的分解破壞。該腸溶膜衣的組成包含如篦麻油、蟲膠、礦物油、丙二醇、聚甲基丙烯酸酯、檸檬酸三乙酯、檸檬酸三丁酯、鄰苯二甲酸二甲酯、鄰苯二甲酸二乙酯、聚乙二醇、鄰苯二甲酸醋酸纖維素、羥丙基鄰苯二甲酸甲基纖維素、羥丙基甲基纖維素琥 珀酸醋酸塩等其中一項或多項組成。 In addition, the present inventors provide another embodiment, the protective layer 10 is an enteric film coating, which is dissolved in the environment of the intestines, and releases the active ingredients of the core effect layer, so that The active ingredient is free from decomposition and destruction of gastric acid. The composition of the enteric coating comprises, for example, castor oil, shellac, mineral oil, propylene glycol, polymethacrylate, triethyl citrate, tributyl citrate, dimethyl phthalate, phthalic acid Diethyl ester, polyethylene glycol, cellulose acetate phthalate, methyl cellulose hydroxypropyl phthalate, hydroxypropyl methyl cellulose One or more of the components such as barium acetate.

本創作的微粒結構除了可直接口服和進行沖泡飲用外,還可充填入膠囊,此膠囊可做為保健食品或醫藥品。又或者,可添加乳糖、澱粉或纖維素等賦型劑以加壓方式打成糖片(壓片糖果),例如製成雙層錠、發泡錠、緩釋錠等。 The particle structure of the present invention can be filled into a capsule in addition to being directly orally and brewed, and the capsule can be used as a health food or a medicine. Alternatively, an excipient such as lactose, starch or cellulose may be added to form a tablet (pressed candy) under pressure, for example, a double-layer ingot, a foamed ingot, a sustained-release ingot or the like.

請參考第5圖及第6A圖至第6D圖,其中,第5圖為中空圓形錠型的口服錠的立體部份剖面圖,而第6A圖至第6D圖分別是本創作的三角形錠型態樣、圓形錠型態樣、四角形錠型態樣、蜆狀錠型態樣的口服錠的示意圖。具體地,在本創作的另一實施例中,如第5圖所示,本創作的口服劑可被壓製成口服錠2,以便於控制單次劑量,該口服錠2可為中空圓形錠型,並由外至內依順序保護層10、甜味劑層20和活性核心層30。本創作的口服錠並無限定外形,如第6A圖至第6D圖所示,分別說明了該口服錠2可為三角形錠型、圓形錠型、四角形錠型、蜆狀錠型。 Please refer to FIG. 5 and FIGS. 6A to 6D, wherein FIG. 5 is a three-dimensional partial cross-sectional view of an oral ingot of a hollow circular ingot type, and FIGS. 6A to 6D are respectively a triangular ingot of the present creation. Schematic diagram of an oral ingot of a profile, a circular ingot shape, a quadrilateral ingot shape, and a scorpion ingot shape. Specifically, in another embodiment of the present invention, as shown in FIG. 5, the oral preparation of the present invention can be compressed into an oral ingot 2 for controlling a single dose, and the oral ingot 2 can be a hollow circular ingot. The protective layer 10, the sweetener layer 20 and the active core layer 30 are sequentially protected from the outside to the inside. The oral ingot of the present invention is not limited in shape, as shown in Figs. 6A to 6D, respectively, and the oral ingot 2 can be a triangular ingot type, a circular ingot type, a quadrangular ingot type, or a serpentine ingot type.

接著,請參考第7圖,是本創作的膠原蛋白微粒結構置於膠囊中的結構分解圖。如第7圖所示,本創作的膠原蛋白微粒結構1可被裝填至一膠囊組合體內,以控制單次服用劑量,其中,該膠囊組合體包括:一第一膠囊殼體31,具有一第一套合口311,而該第一套 合口311的週邊形成一第一鋸齒表面312;一第二膠囊殼體32,具有一第二套合口321,而該第二套合口321的內圍系形成一第二鋸齒表面322,如此,該第二套合口321與該第一套合口311相對套合在一起,且該第一鋸齒表面312及該第二鋸齒表面322互相扣合,使得該第一膠囊殼體31與該第二膠囊殼體32扣合在一起,並在其之間形成封閉的一容置空間33,而本創作的膠原蛋白微粒結構1即被裝填在容置空間33內。該膠囊組合體為一有色膠囊體,可添加食用色素,該食用色素可為食用色素紅色6號、食用色素紅色7號、食用色素黃色4號、食用色素黃色5號、與食用色素藍色1號等等其中之一或其組合。 Next, please refer to Fig. 7, which is a structural exploded view of the collagen particle structure of the present invention placed in a capsule. As shown in Fig. 7, the collagen particle structure 1 of the present invention can be loaded into a capsule assembly to control a single dose, wherein the capsule assembly comprises: a first capsule shell 31 having a first a set of joints 311, and the first set A second serration surface 312 is formed on the periphery of the opening 311; a second capsule housing 32 has a second sleeve opening 321 , and the inner circumference of the second sleeve opening 321 forms a second serrated surface 322. The second set of joints 321 are oppositely sleeved with the first set of joints 311, and the first serrated surface 312 and the second serrated surface 322 are engaged with each other such that the first capsule shell 31 and the second capsule shell The bodies 32 are fastened together and form a closed accommodating space 33 therebetween, and the collagen particle structure 1 of the present invention is filled in the accommodating space 33. The capsule assembly is a colored capsule body, and a food coloring can be added, and the food coloring can be food color red No. 6, food color red No. 7, food color yellow No. 4, food color yellow No. 5, and food coloring blue 1 One of them, or a combination thereof.

請參考第8圖,為膠原蛋白微粒結構自袋體內傾倒至杯體的示意圖。如第8圖所示,本創作的膠原蛋白微粒結構1可與保健食品或醫藥品搭配服用,並裝填於一保健食品袋體4內,服用時,只需將該保健食品袋體4撕開,便可直接口腔攝食,或是,倒入裝有溶液的杯體後直接飲用。為了改變口感,可適當地在該保健食品袋體4內添加甜味,像是糖精鈉、砂糖、葡萄糖、澱粉糖漿、右旋糖、果糖、甘油、異麥芽酮糖醇、乳糖醇、乳糖、麥芽糖醇、麥芽糖、甘露糖醇、山梨糖醇、蔗糖、塔格糖、海藻糖、木糖醇、阿力甜、 阿斯巴甜、乙醯磺胺酸鉀、環拉酸、環拉酸鹽、新橘皮苷二氫查酮、祝馬丁、糖精、糖精鹽、蔗糖素等等。 Please refer to Figure 8 for a schematic diagram of the collagen microparticle structure being poured from the inside of the bag to the cup. As shown in Fig. 8, the collagen microparticle structure 1 of the present invention can be taken together with a health food or a pharmaceutical product, and filled in a health food food bag 4, and only the health food food bag 4 can be torn open when taken. You can directly ingest the food or drink it directly after pouring it into the cup containing the solution. In order to change the mouthfeel, sweetness such as sodium saccharin, sugar, glucose, starch syrup, dextrose, fructose, glycerin, isomalt, lactitol, lactose may be appropriately added to the health food bag 4. , maltitol, maltose, mannitol, sorbitol, sucrose, tagatose, trehalose, xylitol, alitame, Aspartame, acesulfame potassium, cyclamate, cyclamate, neohesperidin dihydrochalcone, martin, saccharin, saccharin, sucralose and the like.

請參考第9圖,係增加防潮層的實施例的結構剖面圖。如第9圖所示,為另一實施例的結構剖面圖,在該實施例中,在還進一步包括一防潮層40,包覆在保護層10的外部。有了該防潮層40可以阻斷空氣中水氣附在膠原蛋白微粒結構表面,避免微粒吸濕而潮解。該防潮層可以使得膠原蛋白微粒結構易於長期保存。該防潮層由麥芽糊精所組成。麥芽糊精的來源並未設有特別的限制,其可由一般市面購置。此層是用一般造粒噴覆技術,於最外層噴附上防潮層,在實施例中,濃度20%至40%的麥芽糊精具有較好的防潮效果,其中較佳為30%。麥芽糊精的濃度與噴覆量依據原料核心的特性加以調整,所屬該技術領域具有通常知識者,皆可輕易由濃度階梯與噴覆厚度的測試,達到其最適的噴覆濃度、噴覆量與防潮效果。 Please refer to Fig. 9, which is a structural sectional view of an embodiment in which a moisture barrier layer is added. As shown in Fig. 9, a structural sectional view of another embodiment, in this embodiment, further includes a moisture barrier layer 40 which is coated on the outside of the protective layer 10. The moisture barrier layer 40 can block the moisture in the air from adhering to the surface of the collagen particle structure to prevent the particles from absorbing moisture and deliquescent. The moisture barrier layer makes the collagen particle structure easy to store for a long time. The moisture barrier layer is composed of maltodextrin. The source of maltodextrin is not specifically limited and can be purchased from the general market. This layer is sprayed with a moisture barrier layer on the outermost layer by a general granulation spray coating technique. In the examples, the maltodextrin having a concentration of 20% to 40% has a good moisture-proof effect, and preferably 30%. The concentration and spray amount of maltodextrin are adjusted according to the characteristics of the core of the raw material. Those skilled in the art can easily test the concentration of the concentration step and the thickness of the spray to achieve the optimum spray concentration and spray coverage. Volume and moisture resistance.

由於本創作的微粒結構中含有膠原蛋白,通過服用本創作的這種膠原蛋白微粒結構,其活性核心層易於被腸道吸收,且經過實驗證明,膠原蛋白的活性核心層在吸收後,能夠補充皮膚中膠原蛋白、促使皮膚保持年輕、同時預防皮膚老化、增強代謝角質、加強消除皺紋、進而恢復皮膚彈性與光澤、達到促進保濕的 功效;且本創作人還提供多種服用的方式,包含製成膠原蛋白粉,壓製成口服錠,或是裝填入膠囊,以方便使用者補充膠原蛋白。 Since the particle structure of the present invention contains collagen, the active core layer is easily absorbed by the intestine by taking the collagen microparticle structure of the present creation, and it has been experimentally proved that the active core layer of collagen can be replenished after absorption. Collagen in the skin, keeping the skin young, preventing skin aging, enhancing metabolic keratin, strengthening wrinkles, restoring skin elasticity and luster, and promoting moisturizing Efficacy; and the author also offers a variety of ways to take, including collagen powder, compressed into oral tablets, or filled into capsules, to facilitate the user to add collagen.

上述之詳細說明係針對本創作可行實施例之具體說明,惟,本技術領域中的普通技術人員應當認識到,以上的實施例僅是用來說明本創作,而並非用作為對本創作的限定,只要在本創作的實質精神範圍內,對以上所述實施例的變化、變型,未脫離本創作精神所為之等效實施或變更,均應包含於本創作之專利範圍中。 The above detailed description is for the specific description of the presently applicable embodiments, and those skilled in the art should understand that the above embodiments are only used to illustrate the present invention, and are not intended to limit the present invention. Changes and modifications of the embodiments described above are intended to be included in the scope of the present invention as long as they are within the scope of the spirit of the present invention.

10‧‧‧保護層 10‧‧‧Protective layer

20‧‧‧甜味劑層 20‧‧‧Sweetener layer

30‧‧‧活性核心層 30‧‧‧Active core layer

Claims (19)

一種改善肌膚狀態的膠原蛋白微粒結構,其特徵在於,包含:一含膠原蛋白的活性核心層;一甜味劑層,其包覆於所述活性核心層的外部;以及一保護層,其包覆於所述甜味劑層的外部。 A collagen microparticle structure for improving skin condition, comprising: a collagen-containing active core layer; a sweetener layer coated on the outside of the active core layer; and a protective layer, which comprises Covering the outside of the sweetener layer. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述活性核心層進一步包含有維生素C、β-胡蘿蔔素、檸檬酸中的一種或任意組合。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the active core layer further comprises one or any combination of vitamin C, β-carotene, and citric acid. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述活性核心層僅包含膠原蛋白。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the active core layer contains only collagen. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,述活性核心層僅包含膠原蛋白和赤蘚糖醇。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the active core layer comprises only collagen and erythritol. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述活性核心層包含膠原蛋白3g-13g。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the active core layer comprises collagen 3g-13g. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述活性核心層包含膠原蛋白和果汁調味粉。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the active core layer comprises collagen and juice flavoring powder. 如申請專利範圍第1、或2、或3、或4、或5、或6項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述膠原蛋白為單一來源的膠原蛋白或任兩種來源的膠原蛋 白的組合。 The collagen microparticle structure for improving skin condition as described in claim 1, 2, 3 or 4, or 5 or 6 wherein the collagen is a single source of collagen or any two Source of collagen eggs White combination. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述甜味劑層所採用的甜味劑選自由葡萄糖、果糖、蔗糖、麥芽糖、澱粉糖,赤蘚糖醇、蔗糖素和乳糖所組成的群組。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the sweetener layer is selected from the group consisting of glucose, fructose, sucrose, maltose, starch sugar, and erythritol. a group consisting of sucralose and lactose. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述保護層為選自可供人體食用的明膠、阿拉伯膠、玉米糖膠、黃耆膠、果膠所組成的群組。 The collagen microparticle structure for improving skin condition according to claim 1, wherein the protective layer is selected from the group consisting of gelatin, gum arabic, corn syrup, tragacanth, and pectin which are usable for human consumption. Group. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述保護層進一步包含一賦形劑,其中該賦形劑選自由調味劑、增甜劑、防腐劑、抗氧化劑、螯合劑、滲透劑、潤滑劑、著色劑、以及結合劑所組成的群組。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the protective layer further comprises an excipient, wherein the excipient is selected from the group consisting of a flavoring agent, a sweetener, a preservative, and an antibiotic A group of oxidizing agents, chelating agents, penetrants, lubricants, colorants, and binders. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述甜味劑層厚度為0.01-0.05mm。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the sweetener layer has a thickness of 0.01 to 0.05 mm. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述保護層厚度為0.01-0.05mm。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the protective layer has a thickness of 0.01 to 0.05 mm. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述活性核心層表面粗糙。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the active core layer has a rough surface. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,還進一步包括有防潮層,包覆於所述保護層的外部。 The collagen microparticle structure for improving skin condition as described in claim 1, further comprising a moisture barrier layer coated on the outside of the protective layer. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述保護層之表面粗糙。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the surface of the protective layer is rough. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,其進一步製成粉劑包或飲品或膠囊或糖片或壓片糖果的形式。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the composition is further in the form of a powder package or a drink or a capsule or a tablet or a tablet candy. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述膠原蛋白微粒結構被壓製成口服錠,且該口服錠可為圓形錠型、橢圓形錠型、三角形錠型、四角形錠型、蜆狀錠型、與中空圓形錠型其中之一或其組合。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the collagen microparticle structure is compressed into an oral ingot, and the oral ingot may be a circular ingot, an elliptical ingot, or a triangle. One of or in combination of an ingot type, a quadrangular ingot type, a serpentine ingot type, and a hollow circular ingot type. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,所述膠原蛋白微粒結構裝填至一膠囊組合體內,其中,該膠囊組合體包括:一第一膠囊殼體,具有一第一套合口,而該第一套合口的週邊形成一第一鋸齒表面;及一第二膠囊殼體,具有一第二套合口,而該第二套合口的內圍形成一第二鋸齒表面,如此,該第二套合口與該第一套合口相對套合在一起,且該第一鋸齒表面及該第二鋸齒表面互相扣合,使得該第一膠囊殼體與該第二膠囊殼體扣合在一起,並在其之間形成封閉的一容置空間。 The collagen microparticle structure for improving skin condition according to claim 1, wherein the collagen microparticle structure is filled into a capsule assembly, wherein the capsule assembly comprises: a first capsule shell having a first set of joints, the periphery of the first set of joints forming a first serrated surface; and a second capsule shell having a second sleeve opening, and the inner circumference of the second sleeve mouth forming a second sawtooth a surface, such that the second socket is oppositely sleeved with the first sleeve, and the first serration surface and the second serration surface are mutually engaged, such that the first capsule shell and the second capsule shell The bodies are fastened together and form a closed space between them. 如申請專利範圍第1項所述之改善肌膚狀態的膠原蛋白微粒結構,其中,其可溶於水中形成溶液後飲用,或 直接經由口腔攝食。 The collagen microparticle structure for improving skin condition as described in claim 1, wherein the composition is soluble in water to form a solution, or Feed directly through the mouth.
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